                         SEQUENCE LISTING

<110>  UMC Utrecht Holding B.V.
 
<120>  Screening method for effective target - E3 ligase combinations

<130>  P6082646pct1

<150>  PCT/EP2021/055551
<151>  2021-03-05

<150>  EP 20180740.1
<151>  2020-06-18

<160>  105   

<170>  PatentIn version 3.5

<210>  1
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Gly Gly His Gln Leu Gln Leu Ala Ala Leu Trp Pro Trp Leu 
1               5                   10                  15      


Leu Met Ala Thr Leu Gln Ala Gly Phe Gly Arg Thr Gly Leu Val Leu 
            20                  25                  30          


Ala Ala Ala Val Glu Ser Glu Arg Ser Ala Glu Gln Lys Ala Ile Ile 
        35                  40                  45              


Arg Val Ile Pro Leu Lys Met Asp Pro Thr Gly Lys Leu Asn Leu Thr 
    50                  55                  60                  


Leu Glu Gly Val Phe Ala Gly Val Ala Glu Ile Thr Pro Ala Glu Gly 
65                  70                  75                  80  


Lys Leu Met Gln Ser His Pro Leu Tyr Leu Cys Asn Ala Ser Asp Asp 
                85                  90                  95      


Asp Asn Leu Glu Pro Gly Phe Ile Ser Ile Val Lys Leu Glu Ser Pro 
            100                 105                 110         


Arg Arg Ala Pro Arg Pro Cys Leu Ser Leu Ala Ser Lys Ala Arg Met 
        115                 120                 125             


Ala Gly Glu Arg Gly Ala Ser Ala Val Leu Phe Asp Ile Thr Glu Asp 
    130                 135                 140                 


Arg Ala Ala Ala Glu Gln Leu Gln Gln Pro Leu Gly Leu Thr Trp Pro 
145                 150                 155                 160 


Val Val Leu Ile Trp Gly Asn Asp Ala Glu Lys Leu Met Glu Phe Val 
                165                 170                 175     


Tyr Lys Asn Gln Lys Ala His Val Arg Ile Glu Leu Lys Glu Pro Pro 
            180                 185                 190         


Ala Trp Pro Asp Tyr Asp Val Trp Ile Leu Met Thr Val Val Gly Thr 
        195                 200                 205             


Ile Phe Val Ile Ile Leu Ala Ser Val Leu Arg Ile Arg Cys Arg Pro 
    210                 215                 220                 


Arg His Ser Arg Pro Asp Pro Leu Gln Gln Arg Thr Ala Trp Ala Ile 
225                 230                 235                 240 


Ser Gln Leu Ala Thr Arg Arg Tyr Gln Ala Ser Cys Arg Gln Ala Arg 
                245                 250                 255     


Gly Glu Trp Pro Asp Ser Gly Ser Ser Cys Ser Ser Ala Pro Val Cys 
            260                 265                 270         


Ala Ile Cys Leu Glu Glu Phe Ser Glu Gly Gln Glu Leu Arg Val Ile 
        275                 280                 285             


Ser Cys Leu His Glu Phe His Arg Asn Cys Val Asp Pro Trp Leu His 
    290                 295                 300                 


Gln His Arg Thr Cys Pro Leu Cys Met Phe Asn Ile Thr Glu Gly Asp 
305                 310                 315                 320 


Ser Phe Ser Gln Ser Leu Gly Pro Ser Arg Ser Tyr Gln Glu Pro Gly 
                325                 330                 335     


Arg Arg Leu His Leu Ile Arg Gln His Pro Gly His Ala His Tyr His 
            340                 345                 350         


Leu Pro Ala Ala Tyr Leu Leu Gly Pro Ser Arg Ser Ala Val Ala Arg 
        355                 360                 365             


Pro Pro Arg Pro Gly Pro Phe Leu Pro Ser Gln Glu Pro Gly Met Gly 
    370                 375                 380                 


Pro Arg His His Arg Phe Pro Arg Ala Ala His Pro Arg Ala Pro Gly 
385                 390                 395                 400 


Glu Gln Gln Arg Leu Ala Gly Ala Gln His Pro Tyr Ala Gln Gly Trp 
                405                 410                 415     


Gly Leu Ser His Leu Gln Ser Thr Ser Gln His Pro Ala Ala Cys Pro 
            420                 425                 430         


Val Pro Leu Arg Arg Ala Arg Pro Pro Asp Ser Ser Gly Ser Gly Glu 
        435                 440                 445             


Ser Tyr Cys Thr Glu Arg Ser Gly Tyr Leu Ala Asp Gly Pro Ala Ser 
    450                 455                 460                 


Asp Ser Ser Ser Gly Pro Cys His Gly Ser Ser Ser Asp Ser Val Val 
465                 470                 475                 480 


Asn Cys Thr Asp Ile Ser Leu Gln Gly Val His Gly Ser Ser Ser Thr 
                485                 490                 495     


Phe Cys Ser Ser Leu Ser Ser Asp Phe Asp Pro Leu Val Tyr Cys Ser 
            500                 505                 510         


Pro Lys Gly Asp Pro Gln Arg Val Asp Met Gln Pro Ser Val Thr Ser 
        515                 520                 525             


Arg Pro Arg Ser Leu Asp Ser Val Val Pro Thr Gly Glu Thr Gln Val 
    530                 535                 540                 


Ser Ser His Val His Tyr His Arg His Arg His His His Tyr Lys Lys 
545                 550                 555                 560 


Arg Phe Gln Trp His Gly Arg Lys Pro Gly Pro Glu Thr Gly Val Pro 
                565                 570                 575     


Gln Ser Arg Pro Pro Ile Pro Arg Thr Gln Pro Gln Pro Glu Pro Pro 
            580                 585                 590         


Ser Pro Asp Gln Gln Val Thr Arg Ser Asn Ser Ala Ala Pro Ser Gly 
        595                 600                 605             


Arg Leu Ser Asn Pro Gln Cys Pro Arg Ala Leu Pro Glu Pro Ala Pro 
    610                 615                 620                 


Gly Pro Val Asp Ala Ser Ser Ile Cys Pro Ser Thr Ser Ser Leu Phe 
625                 630                 635                 640 


Asn Leu Gln Lys Ser Ser Leu Ser Ala Arg His Pro Gln Arg Lys Arg 
                645                 650                 655     


Arg Gly Gly Pro Ser Glu Pro Thr Pro Gly Ser Arg Pro Gln Asp Ala 
            660                 665                 670         


Thr Val His Pro Ala Cys Gln Ile Phe Pro His Tyr Thr Pro Ser Val 
        675                 680                 685             


Ala Tyr Pro Trp Ser Pro Glu Ala His Pro Leu Ile Cys Gly Pro Pro 
    690                 695                 700                 


Gly Leu Asp Lys Arg Leu Leu Pro Glu Thr Pro Gly Pro Cys Tyr Ser 
705                 710                 715                 720 


Asn Ser Gln Pro Val Trp Leu Cys Leu Thr Pro Arg Gln Pro Leu Glu 
                725                 730                 735     


Pro His Pro Pro Gly Glu Gly Pro Ser Glu Trp Ser Ser Asp Thr Ala 
            740                 745                 750         


Glu Gly Arg Pro Cys Pro Tyr Pro His Cys Gln Val Leu Ser Ala Gln 
        755                 760                 765             


Pro Gly Ser Glu Glu Glu Leu Glu Glu Leu Cys Glu Gln Ala Val 
    770                 775                 780             


<210>  2
<211>  2352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  2
atgagtggtg gccaccagct gcagctggct gccctctggc cctggctgct gatggctacc       60

ctgcaggcag gctttggacg cacaggactg gtactggcag cagcggtgga gtctgaaaga      120

tcagcagaac agaaagctat tatcagagtg atccccttga aaatggaccc cacaggaaaa      180

ctgaatctca ctttggaagg tgtgtttgct ggtgttgctg aaataactcc agcagaagga      240

aaattaatgc agtcccaccc gctgtacctg tgcaatgcca gtgatgacga caatctggag      300

cctggattca tcagcatcgt caagctggag agtcctcgac gggccccccg cccctgcctg      360

tcactggcta gcaaggctcg gatggcgggt gagcgaggag ccagtgctgt cctctttgac      420

atcactgagg atcgagctgc tgctgagcag ctgcagcagc cgctggggct gacctggcca      480

gtggtgttga tctggggtaa tgacgctgag aagctgatgg agtttgtgta caagaaccaa      540

aaggcccatg tgaggattga gctgaaggag cccccggcct ggccagatta tgatgtgtgg      600

atcctaatga cagtggtggg caccatcttt gtgatcatcc tggcttcggt gctgcgcatc      660

cggtgccgcc cccgccacag caggccggat ccgcttcagc agagaacagc ctgggccatc      720

agccagctgg ccaccaggag gtaccaggcc agctgcaggc aggcccgggg tgagtggcca      780

gactcaggga gcagctgcag ctcagcccct gtgtgtgcca tctgtctgga ggagttctct      840

gaggggcagg agctacgggt catttcctgc ctccatgagt tccatcgtaa ctgtgtggac      900

ccctggttac atcagcatcg gacttgcccc ctctgcatgt tcaacatcac agagggagat      960

tcattttccc agtccctggg accctctcga tcttaccaag aaccaggtcg aagactccac     1020

ctcattcgcc agcatcccgg ccatgcccac taccacctcc ctgctgccta cctgttgggc     1080

ccttcccgga gtgcagtggc tcggccccca cgacctggtc ccttcctgcc atcccaggag     1140

ccaggcatgg gccctcggca tcaccgcttc cccagagctg cacatccccg ggctccagga     1200

gagcagcagc gcctggcagg agcccagcac ccctatgcac aaggctgggg actgagccac     1260

ctccaatcca cctcacagca ccctgctgct tgcccagtgc ccctacgccg ggccaggccc     1320

cctgacagca gtggatctgg agaaagctat tgcacagaac gcagtgggta cctggcagat     1380

gggccagcca gtgactccag ctcagggccc tgtcatggct cttccagtga ctctgtggtc     1440

aactgcacgg acatcagcct acagggggtc catggcagca gttctacttt ctgcagctcc     1500

ctaagcagtg actttgaccc cctagtgtac tgcagcccta aaggggatcc ccagcgagtg     1560

gacatgcagc ctagtgtgac ctctcggcct cgttccttgg actcggtggt gcccacaggg     1620

gaaacccagg tttccagcca tgtccactac caccgccacc ggcaccacca ctacaaaaag     1680

cggttccagt ggcatggcag gaagcctggc ccagaaaccg gagtccccca gtccaggcct     1740

cctattcctc ggacacagcc ccagccagag ccaccttctc ctgatcagca agtcaccaga     1800

tccaactcag cagccccttc ggggcggctc tctaacccac agtgccccag ggccctccct     1860

gagccagccc ctggcccagt tgacgcctcc agcatctgcc ccagtaccag cagtctgttc     1920

aacttgcaaa aatccagcct ctctgcccga cacccacaga ggaaaaggcg ggggggtccc     1980

tccgagccca cccctggctc tcggccccag gatgcaactg tgcacccagc ttgccagatt     2040

tttccccatt acacccccag tgtggcatat ccttggtccc cagaggcaca ccccttgatc     2100

tgtggacctc caggcctgga caagaggctg ctaccagaaa ccccaggccc ctgttactca     2160

aattcacagc cagtgtggtt gtgcctgact cctcgccagc ccctggaacc acatccacct     2220

ggggaggggc cttctgaatg gagttctgac accgcagagg gcaggccatg cccttatccg     2280

cactgccagg tgctgtcggc ccagcctggc tcagaggagg aactcgagga gctgtgtgaa     2340

caggctgtgt ga                                                         2352


<210>  3
<211>  936
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Pro Arg Ser Gly Gly Arg Pro Gly Ala Thr Gly Arg Arg Arg 
1               5                   10                  15      


Arg Arg Leu Arg Arg Arg Pro Arg Gly Leu Arg Cys Ser Arg Leu Pro 
            20                  25                  30          


Pro Pro Pro Pro Leu Pro Leu Leu Leu Gly Leu Leu Leu Ala Ala Ala 
        35                  40                  45              


Gly Pro Gly Ala Ala Arg Ala Lys Glu Thr Ala Phe Val Glu Val Val 
    50                  55                  60                  


Leu Phe Glu Ser Ser Pro Ser Gly Asp Tyr Thr Thr Tyr Thr Thr Gly 
65                  70                  75                  80  


Leu Thr Gly Arg Phe Ser Arg Ala Gly Ala Thr Leu Ser Ala Glu Gly 
                85                  90                  95      


Glu Ile Val Gln Met His Pro Leu Gly Leu Cys Asn Asn Asn Asp Glu 
            100                 105                 110         


Glu Asp Leu Tyr Glu Tyr Gly Trp Val Gly Val Val Lys Leu Glu Gln 
        115                 120                 125             


Pro Glu Leu Asp Pro Lys Pro Cys Leu Thr Val Leu Gly Lys Ala Lys 
    130                 135                 140                 


Arg Ala Val Gln Arg Gly Ala Thr Ala Val Ile Phe Asp Val Ser Glu 
145                 150                 155                 160 


Asn Pro Glu Ala Ile Asp Gln Leu Asn Gln Gly Ser Glu Asp Pro Leu 
                165                 170                 175     


Lys Arg Pro Val Val Tyr Val Lys Gly Ala Asp Ala Ile Lys Leu Met 
            180                 185                 190         


Asn Ile Val Asn Lys Gln Lys Val Ala Arg Ala Arg Ile Gln His Arg 
        195                 200                 205             


Pro Pro Arg Gln Pro Thr Glu Tyr Phe Asp Met Gly Ile Phe Leu Ala 
    210                 215                 220                 


Phe Phe Val Val Val Ser Leu Val Cys Leu Ile Leu Leu Val Lys Ile 
225                 230                 235                 240 


Lys Leu Lys Gln Arg Arg Ser Gln Asn Ser Met Asn Arg Leu Ala Val 
                245                 250                 255     


Gln Ala Leu Glu Lys Met Glu Thr Arg Lys Phe Asn Ser Lys Ser Lys 
            260                 265                 270         


Gly Arg Arg Glu Gly Ser Cys Gly Ala Leu Asp Thr Leu Ser Ser Ser 
        275                 280                 285             


Ser Thr Ser Asp Cys Ala Ile Cys Leu Glu Lys Tyr Ile Asp Gly Glu 
    290                 295                 300                 


Glu Leu Arg Val Ile Pro Cys Thr His Arg Phe His Arg Lys Cys Val 
305                 310                 315                 320 


Asp Pro Trp Leu Leu Gln His His Thr Cys Pro His Cys Arg His Asn 
                325                 330                 335     


Ile Ile Glu Gln Lys Gly Asn Pro Ser Ala Val Cys Val Glu Thr Ser 
            340                 345                 350         


Asn Leu Ser Arg Gly Arg Gln Gln Arg Val Thr Leu Pro Val His Tyr 
        355                 360                 365             


Pro Gly Arg Val His Arg Thr Asn Ala Ile Pro Ala Tyr Pro Thr Arg 
    370                 375                 380                 


Thr Ser Met Asp Ser His Gly Asn Pro Val Thr Leu Leu Thr Met Asp 
385                 390                 395                 400 


Arg His Gly Glu Gln Ser Leu Tyr Ser Pro Gln Thr Pro Ala Tyr Ile 
                405                 410                 415     


Arg Ser Tyr Pro Pro Leu His Leu Asp His Ser Leu Ala Ala His Arg 
            420                 425                 430         


Cys Gly Leu Glu His Arg Ala Tyr Ser Pro Ala His Pro Phe Arg Arg 
        435                 440                 445             


Pro Lys Leu Ser Gly Arg Ser Phe Ser Lys Ala Ala Cys Phe Ser Gln 
    450                 455                 460                 


Tyr Glu Thr Met Tyr Gln His Tyr Tyr Phe Gln Gly Leu Ser Tyr Pro 
465                 470                 475                 480 


Glu Gln Glu Gly Gln Ser Pro Pro Ser Leu Ala Pro Arg Gly Pro Ala 
                485                 490                 495     


Arg Ala Phe Pro Pro Ser Gly Ser Gly Ser Leu Leu Phe Pro Thr Val 
            500                 505                 510         


Val His Val Ala Pro Pro Ser His Leu Glu Ser Gly Ser Thr Ser Ser 
        515                 520                 525             


Phe Ser Cys Tyr His Gly His Arg Ser Val Cys Ser Gly Tyr Leu Ala 
    530                 535                 540                 


Asp Cys Pro Gly Ser Asp Ser Ser Ser Ser Ser Ser Ser Gly Gln Cys 
545                 550                 555                 560 


His Cys Ser Ser Ser Asp Ser Val Val Asp Cys Thr Glu Val Ser Asn 
                565                 570                 575     


Gln Gly Val Tyr Gly Ser Cys Ser Thr Phe Arg Ser Ser Leu Ser Ser 
            580                 585                 590         


Asp Tyr Asp Pro Phe Ile Tyr Arg Ser Arg Ser Pro Cys Arg Ala Ser 
        595                 600                 605             


Glu Ala Gly Gly Ser Gly Ser Ser Gly Arg Gly Pro Ala Leu Cys Phe 
    610                 615                 620                 


Glu Gly Ser Pro Pro Pro Glu Glu Leu Pro Ala Val His Ser His Gly 
625                 630                 635                 640 


Ala Gly Arg Gly Glu Pro Trp Pro Gly Pro Ala Ser Pro Ser Gly Asp 
                645                 650                 655     


Gln Val Ser Thr Cys Ser Leu Glu Met Asn Tyr Ser Ser Asn Ser Ser 
            660                 665                 670         


Leu Glu His Arg Gly Pro Asn Ser Ser Thr Ser Glu Val Gly Leu Glu 
        675                 680                 685             


Ala Ser Pro Gly Ala Ala Pro Asp Leu Arg Arg Thr Trp Lys Gly Gly 
    690                 695                 700                 


His Glu Leu Pro Ser Cys Ala Cys Cys Cys Glu Pro Gln Pro Ser Pro 
705                 710                 715                 720 


Ala Gly Pro Ser Ala Gly Ala Ala Gly Ser Ser Thr Leu Phe Leu Gly 
                725                 730                 735     


Pro His Leu Tyr Glu Gly Ser Gly Pro Ala Gly Gly Glu Pro Gln Ser 
            740                 745                 750         


Gly Ser Ser Gln Gly Leu Tyr Gly Leu His Pro Asp His Leu Pro Arg 
        755                 760                 765             


Thr Asp Gly Val Lys Tyr Glu Gly Leu Pro Cys Cys Phe Tyr Glu Glu 
    770                 775                 780                 


Lys Gln Val Ala Arg Gly Gly Gly Gly Gly Ser Gly Cys Tyr Thr Glu 
785                 790                 795                 800 


Asp Tyr Ser Val Ser Val Gln Tyr Thr Leu Thr Glu Glu Pro Pro Pro 
                805                 810                 815     


Gly Cys Tyr Pro Gly Ala Arg Asp Leu Ser Gln Arg Ile Pro Ile Ile 
            820                 825                 830         


Pro Glu Asp Val Asp Cys Asp Leu Gly Leu Pro Ser Asp Cys Gln Gly 
        835                 840                 845             


Thr His Ser Leu Gly Ser Trp Gly Gly Thr Arg Gly Pro Asp Thr Pro 
    850                 855                 860                 


Arg Pro His Arg Gly Leu Gly Ala Thr Arg Glu Glu Glu Arg Ala Leu 
865                 870                 875                 880 


Cys Cys Gln Ala Arg Ala Leu Leu Arg Pro Gly Cys Pro Pro Glu Glu 
                885                 890                 895     


Ala Gly Ala Val Arg Ala Asn Phe Pro Ser Ala Leu Gln Asp Thr Gln 
            900                 905                 910         


Glu Ser Ser Thr Thr Ala Thr Glu Ala Ala Gly Pro Arg Ser His Ser 
        915                 920                 925             


Ala Asp Ser Ser Ser Pro Gly Ala 
    930                 935     


<210>  4
<211>  2811
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cdna

<400>  4
atgaggccgc gctcgggcgg gcgcccaggg gccacgggcc gccgccgccg ccgcctgcgc       60

cgccgccccc gcggcctccg gtgcagccgc ctgccgccgc cgccgccgct gccgctgctg      120

ctcgggctgc tgctggcggc cgcggggccc ggcgcggcgc gggccaagga gacggcgttc      180

gtggaggtgg tgctgttcga gtcgagccca agcggcgatt acaccaccta caccaccggc      240

ctcacgggcc gcttctcgcg ggccggggcc acgctcagcg ccgagggcga gatcgtgcag      300

atgcacccac tgggcctatg taataacaat gacgaagagg acttgtatga atatggctgg      360

gtaggagtgg tgaagctgga acagccagaa ttggacccga aaccatgcct cactgtccta      420

ggcaaggcca agcgagcagt acagcgggga gctactgcag tcatctttga tgtgtctgaa      480

aacccagaag ctattgatca gctgaaccag ggctctgaag acccgctcaa gaggccggtg      540

gtgtatgtga agggtgcaga tgccattaag ctgatgaaca tcgtcaacaa gcagaaagtg      600

gctcgagcaa ggatccagca ccgccctcct cgacaaccca ctgaatactt tgacatgggg      660

attttcctgg ctttcttcgt cgtggtctcc ttggtctgcc tcatcctcct tgtcaaaatc      720

aagctgaagc agcgacgcag tcagaattcc atgaacaggc tggctgtgca ggctctagag      780

aagatggaaa ccagaaagtt caactccaag agcaaggggc gccgggaggg gagctgtggg      840

gccctggaca cactcagcag cagctccacg tccgactgtg ccatctgtct ggagaagtac      900

attgatggag aggagctgcg ggtcatcccc tgtactcacc ggtttcacag gaagtgcgtg      960

gacccctggc tgctgcagca ccacacctgc ccccactgtc ggcacaacat catagaacaa     1020

aagggaaacc caagcgcggt gtgtgtggag accagcaacc tctcacgtgg tcggcagcag     1080

agggtgaccc tgccggtgca ttaccccggc cgcgtgcaca ggaccaacgc catcccagcc     1140

taccctacga ggacaagcat ggactcccac ggcaaccccg tcaccttgct gaccatggac     1200

cggcacgggg agcagagcct ctattccccg cagacccccg cctacatccg cagctaccca     1260

cccctccacc tggaccacag cctggccgct caccgctgcg gcctggagca ccgggcctac     1320

tccccagccc accccttccg caggcccaag ttgagtggcc gcagcttctc caaggcagct     1380

tgcttctccc agtatgagac catgtaccag cactactact tccagggcct cagctacccg     1440

gagcaggagg ggcagtcccc acctagcctc gcaccccggg gcccggcccg tgcctttcct     1500

ccgagcggca gtggcagcct gctcttcccc accgtggtgc acgtggcccc gccctcccac     1560

ctggagagcg gcagcacgtc cagcttcagc tgctatcacg gccaccgctc ggtgtgcagt     1620

ggctacctgg ccgactgccc aggcagcgac agcagcagca gcagcagctc cggccagtgc     1680

cactgttcct ccagtgactc tgtggtagac tgcactgagg tcagcaacca gggcgtgtac     1740

gggagctgct ccaccttccg cagctccctc agcagcgact atgacccctt catctaccgc     1800

agccggagcc cctgtcgtgc cagtgaggcg gggggctcgg gcagctcggg ccggggacct     1860

gccctgtgct tcgagggctc cccgcctccc gaggagctcc cggcggtgca cagtcatggt     1920

gctgggcggg gcgagccttg gccgggccct gcctctccct cgggggatca ggtgtccacc     1980

tgcagcctgg agatgaacta cagcagcaac tcctccctgg agcacagggg gcccaatagc     2040

tctacctcag aagtggggct cgaggcttct cctggggccg cccctgacct caggaggacc     2100

tggaaggggg gccacgagtt gccgtcgtgt gcctgctgct gcgagcccca gccctcccca     2160

gccgggccta gcgccggagc agctggcagc agcaccttgt tcctggggcc ccacctctac     2220

gagggctctg gcccggcggg tggggagccc cagtcaggaa gctcccaggg cttgtacggc     2280

cttcaccccg accatttgcc caggacagat ggggtgaaat acgagggtct gccctgctgc     2340

ttctatgaag agaagcaggt ggcccgcggg ggcggagggg gcagcggctg ctacactgag     2400

gactactcgg tgagtgtgca gtacacgctc accgaggaac caccgcccgg ctgctacccc     2460

ggggcccggg acctgagcca gcgcatcccc atcattccag aggatgtgga ctgtgatctg     2520

ggcctgccct cggactgcca agggacccac agcctcggct cctggggtgg gacgcgaggc     2580

ccggataccc cacggcccca caggggcctg ggagcaaccc gggaagagga gcgggctctg     2640

tgctgccagg ctagggccct actgcggcct ggctgccctc cggaggaggc gggtgctgtc     2700

agggccaact tccctagtgc cctccaggac actcaggagt ccagcaccac tgccactgag     2760

gctgcaggac cgagatctca ctcagcagac agcagcagcc cgggagcctg a              2811


<210>  5
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Leu Ser Ile Gly Met Leu Met Leu Ser Ala Thr Gln Val Tyr 
1               5                   10                  15      


Thr Ile Leu Thr Val Gln Leu Phe Ala Phe Leu Asn Leu Leu Pro Val 
            20                  25                  30          


Glu Ala Asp Ile Leu Ala Tyr Asn Phe Glu Asn Ala Ser Gln Thr Phe 
        35                  40                  45              


Asp Asp Leu Pro Ala Arg Phe Gly Tyr Arg Leu Pro Ala Glu Gly Leu 
    50                  55                  60                  


Lys Gly Phe Leu Ile Asn Ser Lys Pro Glu Asn Ala Cys Glu Pro Ile 
65                  70                  75                  80  


Val Pro Pro Pro Val Lys Asp Asn Ser Ser Gly Thr Phe Ile Val Leu 
                85                  90                  95      


Ile Arg Arg Leu Asp Cys Asn Phe Asp Ile Lys Val Leu Asn Ala Gln 
            100                 105                 110         


Arg Ala Gly Tyr Lys Ala Ala Ile Val His Asn Val Asp Ser Asp Asp 
        115                 120                 125             


Leu Ile Ser Met Gly Ser Asn Asp Ile Glu Val Leu Lys Lys Ile Asp 
    130                 135                 140                 


Ile Pro Ser Val Phe Ile Gly Glu Ser Ser Ala Asn Ser Leu Lys Asp 
145                 150                 155                 160 


Glu Phe Thr Tyr Glu Lys Gly Gly His Leu Ile Leu Val Pro Glu Phe 
                165                 170                 175     


Ser Leu Pro Leu Glu Tyr Tyr Leu Ile Pro Phe Leu Ile Ile Val Gly 
            180                 185                 190         


Ile Cys Leu Ile Leu Ile Val Ile Phe Met Ile Thr Lys Phe Val Gln 
        195                 200                 205             


Asp Arg His Arg Ala Arg Arg Asn Arg Leu Arg Lys Asp Gln Leu Lys 
    210                 215                 220                 


Lys Leu Pro Val His Lys Phe Lys Lys Gly Asp Glu Tyr Asp Val Cys 
225                 230                 235                 240 


Ala Ile Cys Leu Asp Glu Tyr Glu Asp Gly Asp Lys Leu Arg Ile Leu 
                245                 250                 255     


Pro Cys Ser His Ala Tyr His Cys Lys Cys Val Asp Pro Trp Leu Thr 
            260                 265                 270         


Lys Thr Lys Lys Thr Cys Pro Val Cys Lys Gln Lys Val Val Pro Ser 
        275                 280                 285             


Gln Gly Asp Ser Asp Ser Asp Thr Asp Ser Ser Gln Glu Glu Asn Glu 
    290                 295                 300                 


Val Thr Glu His Thr Pro Leu Leu Arg Pro Leu Ala Ser Val Ser Ala 
305                 310                 315                 320 


Gln Ser Phe Gly Ala Leu Ser Glu Ser Arg Ser His Gln Asn Met Thr 
                325                 330                 335     


Glu Ser Ser Asp Tyr Glu Glu Asp Asp Asn Glu Asp Thr Asp Ser Ser 
            340                 345                 350         


Asp Ala Glu Asn Glu Ile Asn Glu His Asp Val Val Val Gln Leu Gln 
        355                 360                 365             


Pro Asn Gly Glu Arg Asp Tyr Asn Ile Ala Asn Thr Val 
    370                 375                 380     


<210>  6
<211>  1146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  6
atgctgctct ccatagggat gctcatgctg tcagccacac aagtctacac catcttgact       60

gtccagctct ttgcattctt aaacctactg cctgtagaag cagacatttt agcatataac      120

tttgaaaatg catctcagac atttgatgac ctccctgcaa gatttggtta tagacttcca      180

gctgaaggtt taaagggttt tttgattaac tcaaaaccag agaatgcctg tgaacccata      240

gtgcctccac cagtaaaaga caattcatct ggcactttca tcgtgttaat tagaagactt      300

gattgtaatt ttgatataaa ggttttaaat gcacagagag caggatacaa ggcagccata      360

gttcacaatg ttgattctga tgacctcatt agcatgggat ccaacgacat tgaggtacta      420

aagaaaattg acattccatc tgtctttatt ggtgaatcat cagctaattc tctgaaagat      480

gaattcacat atgaaaaagg gggccacctt atcttagttc cagaatttag tcttcctttg      540

gaatactacc taattccctt ccttatcata gtgggcatct gtctcatctt gatagtcatt      600

ttcatgatca caaaatttgt ccaggataga catagagcta gaagaaacag acttcgtaaa      660

gatcaactta agaaacttcc tgtacataaa ttcaagaaag gagatgagta tgatgtatgt      720

gccatttgtt tggatgagta tgaagatgga gacaaactca gaatccttcc ctgttcccat      780

gcttatcact gcaagtgtgt agacccttgg ctaactaaaa ccaaaaaaac ctgtccagtg      840

tgcaagcaaa aagttgttcc ttctcaaggc gattcagact ctgacacaga cagtagtcaa      900

gaagaaaatg aagtgacaga acatacccct ttactgagac ctttagcttc tgtcagtgcc      960

cagtcatttg gggctttatc ggaatcccgc tcacatcaga acatgacaga atcttcagac     1020

tatgaggaag acgacaatga agatactgac agtagtgatg cagaaaatga aattaatgaa     1080

catgatgtcg tggtccagtt gcagcctaat ggtgaacggg attacaacat agcaaatact     1140

gtttga                                                                1146


<210>  7
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Leu Leu Phe Leu Glu Arg Phe Pro Trp Pro Ser Leu Arg Thr 
1               5                   10                  15      


Tyr Thr Gly Leu Ser Gly Leu Ala Leu Leu Gly Thr Ile Ile Ser Ala 
            20                  25                  30          


Tyr Arg Ala Leu Ser Gln Pro Glu Ala Gly Pro Gly Glu Pro Asp Gln 
        35                  40                  45              


Leu Thr Ala Ser Leu Gln Pro Glu Pro Pro Ala Pro Ala Arg Pro Ser 
    50                  55                  60                  


Ala Gly Gly Pro Arg Ala Arg Asp Val Ala Gln Tyr Leu Leu Ser Asp 
65                  70                  75                  80  


Ser Leu Phe Val Trp Val Leu Val Asn Thr Ala Cys Cys Val Leu Met 
                85                  90                  95      


Leu Val Ala Lys Leu Ile Gln Cys Ile Val Phe Gly Pro Leu Arg Val 
            100                 105                 110         


Ser Glu Arg Gln His Leu Lys Asp Lys Phe Trp Asn Phe Ile Phe Tyr 
        115                 120                 125             


Lys Phe Ile Phe Ile Phe Gly Val Leu Asn Val Gln Thr Val Glu Glu 
    130                 135                 140                 


Val Val Met Trp Cys Leu Trp Phe Ala Gly Leu Val Phe Leu His Leu 
145                 150                 155                 160 


Met Val Gln Leu Cys Lys Asp Arg Phe Glu Tyr Leu Ser Phe Ser Pro 
                165                 170                 175     


Thr Thr Pro Met Ser Ser His Gly Arg Val Leu Ser Leu Leu Val Ala 
            180                 185                 190         


Met Leu Leu Ser Cys Cys Gly Leu Ala Ala Val Cys Ser Ile Thr Gly 
        195                 200                 205             


Tyr Thr His Gly Met His Thr Leu Ala Phe Met Ala Ala Glu Ser Leu 
    210                 215                 220                 


Leu Val Thr Val Arg Thr Ala His Val Ile Leu Arg Tyr Val Ile His 
225                 230                 235                 240 


Leu Trp Asp Leu Asn His Glu Gly Thr Trp Glu Gly Lys Gly Thr Tyr 
                245                 250                 255     


Val Tyr Tyr Thr Asp Phe Val Met Glu Leu Thr Leu Leu Ser Leu Asp 
            260                 265                 270         


Leu Met His His Ile His Met Leu Leu Phe Gly Asn Ile Trp Leu Ser 
        275                 280                 285             


Met Ala Ser Leu Val Ile Phe Met Gln Leu Arg Tyr Leu Phe His Glu 
    290                 295                 300                 


Val Gln Arg Arg Ile Arg Arg His Lys Asn Tyr Leu Arg Val Val Gly 
305                 310                 315                 320 


Asn Met Glu Ala Arg Phe Ala Val Ala Thr Pro Glu Glu Leu Ala Val 
                325                 330                 335     


Asn Asn Asp Asp Cys Ala Ile Cys Trp Asp Ser Met Gln Ala Ala Arg 
            340                 345                 350         


Lys Leu Pro Cys Gly His Leu Phe His Asn Ser Cys Leu Arg Ser Trp 
        355                 360                 365             


Leu Glu Gln Asp Thr Ser Cys Pro Thr Cys Arg Met Ser Leu Asn Ile 
    370                 375                 380                 


Ala Asp Asn Asn Arg Val Arg Glu Glu His Gln Gly Glu Asn Leu Asp 
385                 390                 395                 400 


Glu Asn Leu Val Pro Val Ala Ala Ala Glu Gly Arg Pro Arg Leu Asn 
                405                 410                 415     


Gln His Asn His Phe Phe His Phe Asp Gly Ser Arg Ile Ala Ser Trp 
            420                 425                 430         


Leu Pro Ser Phe Ser Val Glu Val Met His Thr Thr Asn Ile Leu Gly 
        435                 440                 445             


Ile Thr Gln Ala Ser Asn Ser Gln Leu Asn Ala Met Ala His Gln Ile 
    450                 455                 460                 


Gln Glu Met Phe Pro Gln Val Pro Tyr His Leu Val Leu Gln Asp Leu 
465                 470                 475                 480 


Gln Leu Thr Arg Ser Val Glu Ile Thr Thr Asp Asn Ile Leu Glu Gly 
                485                 490                 495     


Arg Ile Gln Val Pro Phe Pro Thr Gln Arg Ser Asp Ser Ile Arg Pro 
            500                 505                 510         


Ala Leu Asn Ser Pro Val Glu Arg Pro Ser Ser Asp Gln Glu Glu Gly 
        515                 520                 525             


Glu Thr Ser Ala Gln Thr Glu Arg Val Pro Leu Asp Leu Ser Pro Arg 
    530                 535                 540                 


Leu Glu Glu Thr Leu Asp Phe Gly Glu Val Glu Val Glu Pro Ser Glu 
545                 550                 555                 560 


Val Glu Asp Phe Glu Ala Arg Gly Ser Arg Phe Ser Lys Ser Ala Asp 
                565                 570                 575     


Glu Arg Gln Arg Met Leu Val Gln Arg Lys Asp Glu Leu Leu Gln Gln 
            580                 585                 590         


Ala Arg Lys Arg Phe Leu Asn Lys Ser Ser Glu Asp Asp Ala Ala Ser 
        595                 600                 605             


Glu Ser Phe Leu Pro Leu Glu Gly Ala Ser Ser Asp Pro Val Thr Leu 
    610                 615                 620                 


Arg Arg Arg Met Leu Ala Ala Ala Ala Glu Arg Arg Leu Gln Lys Gln 
625                 630                 635                 640 


Gln Thr Ser 
            


<210>  8
<211>  1932
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  8
atgccgctgc tcttcctcga gcgcttcccc tggcccagcc tccgcaccta cacgggcctc       60

agcggcctgg ccctgctggg caccatcatc agcgcctacc gcgcgctcag ccagcccgag      120

gccggccccg gcgagccgga ccagctaacg gcctcgctgc agcctgagcc gccggcgccc      180

gcccggccga gcgccggggg accccgggcc cgcgatgtgg cccagtacct gctctcagac      240

agcctcttcg tgtgggttct agtaaatacc gcttgctgtg ttttgatgtt ggtggctaag      300

ctcatccagt gtattgtgtt tggccctctt cgagtgagtg agagacagca tctcaaagac      360

aaattttgga attttatttt ctacaagttc attttcatct ttggtgtgct gaatgtccag      420

acagtggaag aggtggtcat gtggtgcctc tggtttgccg gacttgtctt tctgcacctg      480

atggttcagc tctgcaagga tcgatttgaa tatctttcct tctcgcccac cacgccgatg      540

agcagccacg gtcgagtcct gtccctgttg gttgccatgc tgctttcctg ctgtggactg      600

gcggccgtct gctccatcac cggctacacc cacggaatgc acaccttggc tttcatggct      660

gcagagtctc ttcttgtgac agtgaggact gctcatgtga ttttacgata cgtaattcac      720

ctctgggacc tcaaccacga agggacgtgg gaaggaaagg ggacgtatgt ctattacaca      780

gactttgtca tggagctcac tctcctgtcc ctggacctca tgcaccatat tcacatgttg      840

ttatttggca acatctggtt atccatggcc agcctggtca tctttatgca gctgcgttac      900

ctgtttcatg aggtgcaacg tcgaattcgt cggcacaaga actatctacg tgtggttgga      960

aacatggagg ccaggtttgc agttgcaact ccagaggagc tggctgtcaa caatgacgac     1020

tgtgccatct gttgggactc catgcaggct gcgcggaaac tgccctgtgg acatcttttc     1080

cacaactcct gtcttcgttc ctggctagaa caagacacct cctgtccaac atgcagaatg     1140

tctcttaata ttgccgacaa taatcgtgtc agggaagaac atcaaggaga gaacttggat     1200

gagaatttgg ttcctgtagc agcagccgaa gggagacctc gcttaaacca acacaatcac     1260

ttcttccatt tcgatgggtc tcggattgcg agctggctgc cgagtttttc ggttgaagtg     1320

atgcacacca ccaacattct tggcattacg caggccagca actcccagct caatgcaatg     1380

gctcatcaga ttcaagagat gtttccccag gttccatacc atctggtact gcaggacctc     1440

cagctgacac gctcagttga aataacaaca gacaatattt tagaaggacg gattcaagta     1500

ccttttccta cacagcggtc agatagcatc agacctgcat tgaacagtcc tgtggaaagg     1560

ccaagcagtg accaggaaga gggagaaact tctgctcaga ccgagcgtgt gccactggac     1620

ctcagtcctc gcctggagga gacgctggac ttcggcgagg tggaagtgga gcccagtgag     1680

gtggaagact tcgaggctcg tgggagccgc ttctccaagt ctgctgatga gagacagcgc     1740

atgctggtgc agcgtaagga cgaactcctc cagcaagctc gcaaacgttt cttgaacaaa     1800

agttctgaag atgatgcggc ctcagagagc ttcctcccct tggaaggtgc gtcctctgac     1860

cccgtgaccc tgcgtcgaag gatgctggct gccgccgcgg aacggaggct tcagaagcag     1920

cagacctcct ag                                                         1932


<210>  9
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Ser Ser His Val Cys Cys Asn Phe Leu Asn Met Trp Lys Lys 
1               5                   10                  15      


Ser Lys Ile Ser Thr Met Tyr Tyr Leu Asn Gln Asp Ala Lys Leu Ser 
            20                  25                  30          


Asn Leu Phe Leu Gln Ala Ser Ser Pro Thr Thr Gly Thr Ala Pro Arg 
        35                  40                  45              


Ser Gln Ser Arg Leu Ser Val Cys Pro Ser Thr Gln Asp Ile Cys Arg 
    50                  55                  60                  


Ile Cys His Cys Glu Gly Asp Glu Glu Ser Pro Leu Ile Thr Pro Cys 
65                  70                  75                  80  


Arg Cys Thr Gly Thr Leu Arg Phe Val His Gln Ser Cys Leu His Gln 
                85                  90                  95      


Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr Asp 
            100                 105                 110         


Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys Leu 
        115                 120                 125             


Gln Met Thr Thr Ser Glu Arg Arg Lys Ile Phe Cys Ser Val Thr Phe 
    130                 135                 140                 


His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu Ile 
145                 150                 155                 160 


Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Asn Asp Asn Gly Val Leu 
                165                 170                 175     


Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe Thr 
            180                 185                 190         


Gly Gly Leu Val Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln Leu 
        195                 200                 205             


Trp Arg Arg Leu Lys Ala Tyr Asn Arg Val Ile Phe Val Gln Asn Cys 
    210                 215                 220                 


Pro Asp Thr Ala Lys Lys Leu Glu Lys Asn Phe Ser Cys Asn Val Asn 
225                 230                 235                 240 


Thr Asp Ile Lys Asp Ala Val Val Val Pro Val Pro Gln Thr Gly Ala 
                245                 250                 255     


Asn Ser Leu Pro Ser Ala Glu Gly Gly Pro Pro Glu Val Val Ser Val 
            260                 265                 270         


<210>  10
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  10
atgaccagca gccacgtttg ttgtaatttt ttaaatatgt ggaaaaaaag caagatatca       60

accatgtatt accttaacca agatgccaaa ttatctaact tgtttctcca ggcaagcagc      120

ccaacaacag ggacagctcc caggagccag tcaaggttgt ctgtctgtcc atccactcag      180

gacatctgca gaatctgtca ctgcgaaggg gatgaagaga gccccctcat cacaccctgt      240

cgctgcactg ggacactgcg ctttgtccac cagtcctgcc tccaccagtg gataaagagc      300

tcagatacac gctgctgtga gctctgcaag tatgacttca taatggagac caagctcaaa      360

cccctccgga agtgggagaa actacagatg accacaagtg aaaggaggaa aatattctgc      420

tctgtcacat tccacgtaat cgcaatcacc tgtgtggttt ggtctttgta tgtattgata      480

gaccggacag cggaggaaat caagcaaggc aatgacaatg gtgtccttga atggccattt      540

tggacaaaac tggttgtggt agccattggc ttcacaggag gtcttgtctt catgtacgta      600

cagtgtaaag tctatgttca gttgtggcgc aggctgaagg cctacaaccg tgtgatcttt      660

gtacaaaatt gcccagacac tgccaaaaaa ctggagaaga acttctcatg taatgtaaac      720

acagacatca aagatgctgt ggtagtgcct gtaccacaaa caggtgcaaa ttcactgcca      780

tctgcagagg gtggcccccc tgaagttgta tcagtctga                             819


<210>  11
<211>  704
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Ser Lys Pro Ser Arg Ile Pro Arg Arg Ile Ser Val Gln Pro 
1               5                   10                  15      


Ser Ser Ser Leu Ser Ala Arg Met Met Ser Gly Ser Arg Gly Ser Ser 
            20                  25                  30          


Leu Asn Asp Thr Tyr His Ser Arg Asp Ser Ser Phe Arg Leu Asp Ser 
        35                  40                  45              


Glu Tyr Gln Ser Thr Ser Ala Ser Ala Ser Ala Ser Pro Phe Gln Ser 
    50                  55                  60                  


Ala Trp Tyr Ser Glu Ser Glu Ile Thr Gln Gly Ala Arg Ser Arg Ser 
65                  70                  75                  80  


Gln Asn Gln Gln Arg Asp His Asp Ser Lys Arg Pro Lys Leu Ser Cys 
                85                  90                  95      


Thr Asn Cys Thr Thr Ser Ala Gly Arg Asn Val Gly Asn Gly Leu Asn 
            100                 105                 110         


Thr Leu Ser Asp Ser Ser Trp Arg His Ser Gln Val Pro Arg Ser Ser 
        115                 120                 125             


Ser Met Val Leu Gly Ser Phe Gly Thr Asp Leu Met Arg Glu Arg Arg 
    130                 135                 140                 


Asp Leu Glu Arg Arg Thr Asp Ser Ser Ile Ser Asn Leu Met Asp Tyr 
145                 150                 155                 160 


Ser His Arg Ser Gly Asp Phe Thr Thr Ser Ser Tyr Val Gln Asp Arg 
                165                 170                 175     


Val Pro Ser Tyr Ser Gln Gly Ala Arg Pro Lys Glu Asn Ser Met Ser 
            180                 185                 190         


Thr Leu Gln Leu Asn Thr Ser Ser Thr Asn His Gln Leu Pro Ser Glu 
        195                 200                 205             


His Gln Thr Ile Leu Ser Ser Arg Asp Ser Arg Asn Ser Leu Arg Ser 
    210                 215                 220                 


Asn Phe Ser Ser Arg Glu Ser Glu Ser Ser Arg Ser Asn Thr Gln Pro 
225                 230                 235                 240 


Gly Phe Ser Tyr Ser Ser Ser Arg Asp Glu Ala Pro Ile Ile Ser Asn 
                245                 250                 255     


Ser Glu Arg Val Val Ser Ser Gln Arg Pro Phe Gln Glu Ser Ser Asp 
            260                 265                 270         


Asn Glu Gly Arg Arg Thr Thr Arg Arg Leu Leu Ser Arg Ile Ala Ser 
        275                 280                 285             


Ser Met Ser Ser Thr Phe Phe Ser Arg Arg Ser Ser Gln Asp Ser Leu 
    290                 295                 300                 


Asn Thr Arg Ser Leu Asn Ser Glu Asn Ser Tyr Val Ser Pro Arg Ile 
305                 310                 315                 320 


Leu Thr Ala Ser Gln Ser Arg Ser Asn Val Pro Ser Ala Ser Glu Val 
                325                 330                 335     


Pro Asp Asn Arg Ala Ser Glu Ala Ser Gln Gly Phe Arg Phe Leu Arg 
            340                 345                 350         


Arg Arg Trp Gly Leu Ser Ser Leu Ser His Asn His Ser Ser Glu Ser 
        355                 360                 365             


Asp Ser Glu Asn Phe Asn Gln Glu Ser Glu Gly Arg Asn Thr Gly Pro 
    370                 375                 380                 


Trp Leu Ser Ser Ser Leu Arg Asn Arg Cys Thr Pro Leu Phe Ser Arg 
385                 390                 395                 400 


Arg Arg Arg Glu Gly Arg Asp Glu Ser Ser Arg Ile Pro Thr Ser Asp 
                405                 410                 415     


Thr Ser Ser Arg Ser His Ile Phe Arg Arg Glu Ser Asn Glu Val Val 
            420                 425                 430         


His Leu Glu Ala Gln Asn Asp Pro Leu Gly Ala Ala Ala Asn Arg Pro 
        435                 440                 445             


Gln Ala Ser Ala Ala Ser Ser Ser Ala Thr Thr Gly Gly Ser Thr Ser 
    450                 455                 460                 


Asp Ser Ala Gln Gly Gly Arg Asn Thr Gly Ile Ser Gly Ile Leu Pro 
465                 470                 475                 480 


Gly Ser Leu Phe Arg Phe Ala Val Pro Pro Ala Leu Gly Ser Asn Leu 
                485                 490                 495     


Thr Asp Asn Val Met Ile Thr Val Asp Ile Ile Pro Ser Gly Trp Asn 
            500                 505                 510         


Ser Ala Asp Gly Lys Ser Asp Lys Thr Lys Ser Ala Pro Ser Arg Asp 
        515                 520                 525             


Pro Glu Arg Leu Gln Lys Ile Lys Glu Ser Leu Leu Leu Glu Asp Ser 
    530                 535                 540                 


Glu Glu Glu Glu Gly Asp Leu Cys Arg Ile Cys Gln Met Ala Ala Ala 
545                 550                 555                 560 


Ser Ser Ser Asn Leu Leu Ile Glu Pro Cys Lys Cys Thr Gly Ser Leu 
                565                 570                 575     


Gln Tyr Val His Gln Asp Cys Met Lys Lys Trp Leu Gln Ala Lys Ile 
            580                 585                 590         


Asn Ser Gly Ser Ser Leu Glu Ala Val Thr Thr Cys Glu Leu Cys Lys 
        595                 600                 605             


Glu Lys Leu Glu Leu Asn Leu Glu Asp Phe Asp Ile His Glu Leu His 
    610                 615                 620                 


Arg Ala His Ala Asn Glu Gln Ala Glu Tyr Glu Phe Ile Ser Ser Gly 
625                 630                 635                 640 


Leu Tyr Leu Val Val Leu Leu His Leu Cys Glu Gln Ser Phe Ser Asp 
                645                 650                 655     


Met Met Gly Asn Thr Asn Glu Pro Ser Thr Arg Val Arg Phe Ile Asn 
            660                 665                 670         


Leu Ala Arg Thr Leu Gln Ala His Met Glu Asp Leu Glu Thr Ser Glu 
        675                 680                 685             


Asp Asp Ser Glu Glu Asp Gly Asp His Asn Arg Thr Phe Asp Ile Ala 
    690                 695                 700                 


<210>  12
<211>  2115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  12
atggagtcta aaccttcaag gattccaaga agaatttctg ttcaaccttc cagctcctta       60

agtgctagga tgatgtctgg aagcagagga agtagtttaa atgataccta tcactcaaga      120

gactcttcat ttagattgga ttctgaatat cagtctacat cagcatcagc atctgcgtca      180

ccatttcaat ctgcatggta tagtgaatct gagataactc agggagcacg ctcaagatcg      240

cagaaccagc aacgggatca tgattcaaaa agacctaaac tttcctgtac aaactgtact      300

acctcagctg ggagaaatgt tggaaatggt ttaaacacat tatcagattc atcttggagg      360

catagtcaag ttcctagatc ttcatcaatg gtacttggat catttggaac agacttaatg      420

agagagagga gagatttgga gagaagaaca gattcctcta ttagtaatct tatggattat      480

agtcaccgaa gtggtgattt cacaacttca tcatatgttc aagacagagt tccttcatat      540

tcacaaggag caagaccaaa agaaaactca atgagcactt tacagttgaa tacatcatcc      600

acaaaccacc aattgccttc tgaacatcag accatactaa gttctaggga ctccagaaat      660

tctttaagat caaatttttc ttcaagagaa tcagaatctt cccgaagcaa tacgcagcct      720

ggattttctt acagttcaag tagagatgaa gccccaatca taagcaattc agaaagggtt      780

gtttcatctc aaagaccatt tcaagaatct tctgacaatg aaggtaggcg gacaacgagg      840

agattgctgt cacgcatagc ttctagcatg tcatctactt ttttttcacg aagatctagt      900

caggattcct tgaatacaag atcattgaat tctgaaaatt cttacgtttc tccaagaatc      960

ttgacagctt cacagtcccg tagtaatgta ccatcagctt ctgaagttcc cgataatagg     1020

gcatctgaag cttctcaggg atttcgattt cttaggcgaa gatggggttt gtcatctctt     1080

agccacaatc atagctctga gtcagattca gaaaatttta accaagaatc tgaaggtaga     1140

aatacaggac catggttatc ttcctcactt agaaatagat gcacaccttt gttctctaga     1200

aggaggcgag agggaagaga tgaatcttca aggataccta cctctgatac atcatctaga     1260

tctcatattt ttagaagaga atcaaatgaa gtggttcacc ttgaagcaca gaatgatcct     1320

cttggagctg ctgccaacag accacaagca tctgcagcat caagcagtgc cacaacaggt     1380

ggctctacat cagattcggc tcaaggtgga agaaatacag gaatatcagg gattcttcct     1440

ggttccttat tccggtttgc agtccctcca gcacttggga gtaatttgac cgacaatgtc     1500

atgatcacag tagatattat tccttcaggt tggaattcag ctgatggtaa aagtgataaa     1560

actaaaagtg cgccttcaag agatccagaa agattgcaga aaataaaaga gagcctcctt     1620

ttagaggact cagaagaaga agaaggtgac ttatgtagaa tttgtcaaat ggcagctgca     1680

tcatcatcta atttgctgat agagccatgc aagtgcacag gaagtttgca gtatgtccac     1740

caagactgta tgaaaaagtg gttacaggcc aaaattaact ctggttcttc attagaagct     1800

gtaaccacct gtgaactatg taaagagaag ttggagctta acctggagga ttttgatatt     1860

catgaactac atagagctca tgcaaatgaa caagctgagt atgagtttat cagctctggt     1920

ctctacctag tggtgttatt gcacttgtgc gaacaaagct tttctgatat gatgggaaat     1980

acaaatgaac caagcacacg tgtccgattt attaaccttg caagaactct tcaggcacat     2040

atggaagatc tcgaaacttc agaggatgat tccgaagaag acggagacca taacaggaca     2100

tttgatattg cctaa                                                      2115


<210>  13
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Thr Gly Asp Cys Cys His Leu Pro Gly Ser Leu Cys Asp Cys 
1               5                   10                  15      


Ser Gly Ser Pro Ala Phe Ser Lys Val Val Glu Ala Thr Gly Leu Gly 
            20                  25                  30          


Pro Pro Gln Tyr Val Ala Gln Val Thr Ser Arg Asp Gly Arg Leu Leu 
        35                  40                  45              


Ser Thr Val Ile Arg Ala Leu Asp Thr Pro Ser Asp Gly Pro Phe Cys 
    50                  55                  60                  


Arg Ile Cys His Glu Gly Ala Asn Gly Glu Cys Leu Leu Ser Pro Cys 
65                  70                  75                  80  


Gly Cys Thr Gly Thr Leu Gly Ala Val His Lys Ser Cys Leu Glu Lys 
                85                  90                  95      


Trp Leu Ser Ser Ser Asn Thr Ser Tyr Cys Glu Leu Cys His Thr Glu 
            100                 105                 110         


Phe Ala Val Glu Lys Arg Pro Arg Pro Leu Thr Glu Trp Leu Lys Asp 
        115                 120                 125             


Pro Gly Pro Arg Thr Glu Lys Arg Thr Leu Cys Cys Asp Met Val Cys 
    130                 135                 140                 


Phe Leu Phe Ile Thr Pro Leu Ala Ala Ile Ser Gly Trp Leu Cys Leu 
145                 150                 155                 160 


Arg Gly Ala Gln Asp His Leu Arg Leu His Ser Gln Leu Glu Ala Val 
                165                 170                 175     


Gly Leu Ile Ala Leu Thr Ile Ala Leu Phe Thr Ile Tyr Val Leu Trp 
            180                 185                 190         


Thr Leu Val Ser Phe Arg Tyr His Cys Gln Leu Tyr Ser Glu Trp Arg 
        195                 200                 205             


Lys Thr Asn Gln Lys Val Arg Leu Lys Ile Arg Glu Ala Asp Ser Pro 
    210                 215                 220                 


Glu Gly Pro Gln His Ser Pro Leu Ala Ala Gly Leu Leu Lys Lys Val 
225                 230                 235                 240 


Ala Glu Glu Thr Pro Val 
                245     


<210>  14
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  14
atgacgacgg gtgactgctg ccacctcccc ggctccctgt gtgactgctc cggcagccct       60

gccttctcca aggtcgtgga ggctacgggc ctcggaccgc cccagtatgt ggcacaggtg      120

acttcaaggg atggccggct cctctccacc gtcatccgtg ccttggacac accgagtgat      180

ggtcctttct gccggatctg ccatgaggga gcgaacgggg agtgcttgct gtccccgtgt      240

ggctgcaccg gcacgctggg tgccgtgcat aagagctgtc tggagaagtg gctttcctca      300

tctaacacca gctactgcga gctgtgccac acggagtttg cagtggagaa acggcctcga      360

cccctcacag agtggctgaa ggacccgggg ccgcggacgg agaagcggac actgtgctgc      420

gacatggtgt gtttcctgtt catcacaccg ctggccgcca tctcaggctg gttgtgcctg      480

cgcggggccc aggaccacct ccggctccac agccagctgg aggccgtggg tctcattgcc      540

ctcaccatcg ccctcttcac catctatgtc ctctggacgc tggtctcctt ccgctaccac      600

tgccagctgt actccgagtg gagaaagacc aaccagaaag ttcgcctgaa gatccgggag      660

gcggacagcc ccgagggccc ccagcattct ccactggcag ctggactcct gaagaaggtg      720

gcagaggaga caccagtatg a                                                741


<210>  15
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Met Pro Leu His Gln Ile Ser Ala Ile Pro Ser Gln Asp Ala 
1               5                   10                  15      


Ile Ser Ala Arg Val Tyr Arg Ser Lys Thr Lys Glu Lys Glu Arg Glu 
            20                  25                  30          


Glu Gln Asn Glu Lys Thr Leu Gly His Phe Met Ser His Ser Ser Asn 
        35                  40                  45              


Ile Ser Lys Ala Gly Ser Pro Pro Ser Ala Ser Ala Pro Ala Pro Val 
    50                  55                  60                  


Ser Ser Phe Ser Arg Thr Ser Ile Thr Pro Ser Ser Gln Asp Ile Cys 
65                  70                  75                  80  


Arg Ile Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu Ile Thr Pro 
                85                  90                  95      


Cys His Cys Thr Gly Ser Leu His Phe Val His Gln Ala Cys Leu Gln 
            100                 105                 110         


Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys Lys Tyr 
        115                 120                 125             


Glu Phe Ile Met Glu Thr Lys Leu Lys Pro Leu Arg Lys Trp Glu Lys 
    130                 135                 140                 


Leu Gln Met Thr Ser Ser Glu Arg Arg Lys Ile Met Cys Ser Val Thr 
145                 150                 155                 160 


Phe His Val Ile Ala Ile Thr Cys Val Val Trp Ser Leu Tyr Val Leu 
                165                 170                 175     


Ile Asp Arg Thr Ala Glu Glu Ile Lys Gln Gly Gln Ala Thr Gly Ile 
            180                 185                 190         


Leu Glu Trp Pro Phe Trp Thr Lys Leu Val Val Val Ala Ile Gly Phe 
        195                 200                 205             


Thr Gly Gly Leu Leu Phe Met Tyr Val Gln Cys Lys Val Tyr Val Gln 
    210                 215                 220                 


Leu Trp Lys Arg Leu Lys Ala Tyr Asn Arg Val Ile Tyr Val Gln Asn 
225                 230                 235                 240 


Cys Pro Glu Thr Ser Lys Lys Asn Ile Phe Glu Lys Ser Pro Leu Thr 
                245                 250                 255     


Glu Pro Asn Phe Glu Asn Lys His Gly His Gly Ile Cys His Ser Asp 
            260                 265                 270         


Thr Asn Ser Ser Cys Cys Thr Glu Pro Glu Asp Thr Gly Ala Glu Ile 
        275                 280                 285             


Ile His Val 
    290     


<210>  16
<211>  876
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  16
atgagcatgc cactgcatca gatctctgcc attccatccc aggatgccat ctctgctaga       60

gtctacagaa gtaagaccaa agaaaaggag agggaagaac agaatgagaa gactttggga      120

catttcatga gtcattcaag caacatttct aaggctggga gtcctccgtc agcatcagct      180

ccggctccgg tgtcctcctt ctctcgcact tctatcacgc catccagcca ggacatctgc      240

aggatctgcc actgtgaagg agatgatgag agccccctga tcaccccctg ccactgcaca      300

ggaagcctcc acttcgtgca ccaggcctgc ctgcagcagt ggatcaagag ctccgacacg      360

cgctgctgcg agctctgcaa gtatgagttc atcatggaga ccaagctgaa gccactgaga      420

aaatgggaga agttgcagat gacgtccagc gagcgcagga agatcatgtg ctcagtgaca      480

ttccacgtca ttgccatcac atgtgtggtc tggtccttgt atgtgctcat tgaccgtact      540

gctgaggaga tcaagcaggg gcaggcaaca ggaatcctag aatggccctt ttggactaaa      600

ttggtggttg tggccatcgg cttcaccgga ggacttcttt ttatgtatgt tcagtgtaaa      660

gtgtatgtgc aattgtggaa gagactcaag gcctataata gagtgatcta tgttcaaaac      720

tgtccagaaa caagcaaaaa gaatattttt gaaaaatctc cactaacaga gcccaacttt      780

gaaaataaac atggacatgg aatctgtcat tccgacacaa actcttcttg ttgcacagag      840

cctgaagaca ctggagcaga aatcattcac gtctga                                876


<210>  17
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Leu Lys Ser Arg Leu Arg Met Phe Leu Asn Glu Leu Lys Leu Leu 
1               5                   10                  15      


Val Leu Thr Gly Gly Gly Arg Pro Arg Ala Glu Pro Gln Pro Arg Gly 
            20                  25                  30          


Gly Arg Gly Gly Gly Cys Gly Trp Ala Pro Phe Ala Gly Cys Ser Thr 
        35                  40                  45              


Arg Asp Gly Asp Gly Asp Glu Glu Glu Tyr Tyr Gly Ser Glu Pro Arg 
    50                  55                  60                  


Ala Arg Gly Leu Ala Gly Asp Lys Glu Pro Arg Ala Gly Pro Leu Pro 
65                  70                  75                  80  


Pro Pro Ala Pro Pro Leu Pro Pro Pro Gly Ala Leu Asp Ala Leu Ser 
                85                  90                  95      


Leu Ser Ser Ser Leu Asp Ser Gly Leu Arg Thr Pro Gln Cys Arg Ile 
            100                 105                 110         


Cys Phe Gln Gly Pro Glu Gln Gly Glu Leu Leu Ser Pro Cys Arg Cys 
        115                 120                 125             


Asp Gly Ser Val Arg Cys Thr His Gln Pro Cys Leu Ile Arg Trp Ile 
    130                 135                 140                 


Ser Glu Arg Gly Ser Trp Ser Cys Glu Leu Cys Tyr Phe Lys Tyr Gln 
145                 150                 155                 160 


Val Leu Ala Ile Ser Thr Lys Asn Pro Leu Gln Trp Gln Ala Ile Ser 
                165                 170                 175     


Leu Thr Val Ile Glu Lys Val Gln Ile Ala Ala Ile Val Leu Gly Ser 
            180                 185                 190         


Leu Phe Leu Val Ala Ser Ile Ser Trp Leu Ile Trp Ser Ser Leu Ser 
        195                 200                 205             


Pro Ser Ala Lys Trp Gln Arg Gln Asp Leu Leu Phe Gln Ile Cys Tyr 
    210                 215                 220                 


Gly Met Tyr Gly Phe Met Asp Val Val Cys Ile Gly Leu Ile Ile His 
225                 230                 235                 240 


Glu Gly Ser Ser Val Tyr Arg Ile Phe Lys Arg Trp Gln Ala Val Asn 
                245                 250                 255     


Gln Gln Trp Lys Val Leu Asn Tyr Asp Lys Thr Lys Asp Ile Gly Gly 
            260                 265                 270         


Asp Ala Gly Gly Gly Thr Ala Gly Lys Ser Gly Pro Arg Asn Ser Arg 
        275                 280                 285             


Thr Gly Pro Thr Ser Gly Ala Thr Ser Arg Pro Pro Ala Ala Gln Arg 
    290                 295                 300                 


Met Arg Thr Leu Leu Pro Gln Arg Cys Gly Tyr Thr Ile Leu His Leu 
305                 310                 315                 320 


Leu Gly Gln Leu Arg Pro Pro Asp Ala Arg Ser Ser Ser His Ser Gly 
                325                 330                 335     


Arg Glu Val Val Met Arg Val Thr Thr Val 
            340                 345     


<210>  18
<211>  1041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  18
atgctcaagt ctcggctccg catgtttctg aacgagctga agctgctggt gctgacaggc       60

ggggggcggc cccgggccga gccgcaaccc cgggggggcc ggggaggcgg ctgcggctgg      120

gcgcccttcg ctggctgctc cacccgggac ggcgacggcg acgaggagga gtactacggg      180

tcggagccgc gggcccgggg cctggccggc gacaaggagc cgcgggccgg acccctgccg      240

ccgcccgcgc cgccgctgcc gcccccgggc gcgctggacg ccctgtcgct cagcagtagc      300

ctggacagcg gactccgaac ccctcagtgc cggatctgct tccagggccc ggagcagggg      360

gagctcttaa gcccctgccg ctgcgacggc tcagtgcgct gcacgcatca gccctgcctc      420

atccgctgga tcagcgagag gggctcctgg agctgtgagc tctgctactt caagtaccag      480

gtcctggcga tcagcaccaa gaacccactg cagtggcagg ccatctccct gacggtcatc      540

gagaaggtcc agattgctgc catagttctg ggctcgctct tcctggttgc cagcatctcc      600

tggctcatct ggtcctcact cagcccttca gccaagtggc aacgacagga tctgctcttt      660

cagatctgct acggcatgta tggcttcatg gatgtcgtct gcataggcct catcatccat      720

gaaggctcct ctgtctaccg catcttcaag cgctggcagg cagtgaacca gcagtggaag      780

gtcctaaatt atgacaagac caaggacata ggaggagatg cagggggagg gacggcaggg      840

aagtcaggcc ccaggaactc acggacgggc cccacctctg gggccacgag ccgcccccca      900

gctgcccagc gcatgcggac gctcttgcct cagcgctgcg gttatacaat cttgcacctc      960

cttgggcagc tgcggccacc agatgcccgt tccagctccc attctggccg agaggttgtc     1020

atgagggtca ctacagtctg a                                               1041


<210>  19
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Trp Arg Arg Arg Glu Ala Ser Val Gly Ala Arg Gly Val Leu 
1               5                   10                  15      


Ala Leu Ala Leu Leu Ala Leu Ala Leu Cys Val Pro Gly Ala Arg Gly 
            20                  25                  30          


Arg Ala Leu Glu Trp Phe Ser Ala Val Val Asn Ile Glu Tyr Val Asp 
        35                  40                  45              


Pro Gln Thr Asn Leu Thr Val Trp Ser Val Ser Glu Ser Gly Arg Phe 
    50                  55                  60                  


Gly Asp Ser Ser Pro Lys Glu Gly Ala His Gly Leu Val Gly Val Pro 
65                  70                  75                  80  


Trp Ala Pro Gly Gly Asp Leu Glu Gly Cys Ala Pro Asp Thr Arg Phe 
                85                  90                  95      


Phe Val Pro Glu Pro Gly Gly Arg Gly Ala Ala Pro Trp Val Ala Leu 
            100                 105                 110         


Val Ala Arg Gly Gly Cys Thr Phe Lys Asp Lys Val Leu Val Ala Ala 
        115                 120                 125             


Arg Arg Asn Ala Ser Ala Val Val Leu Tyr Asn Glu Glu Arg Tyr Gly 
    130                 135                 140                 


Asn Ile Thr Leu Pro Met Ser His Ala Gly Thr Gly Asn Ile Val Val 
145                 150                 155                 160 


Ile Met Ile Ser Tyr Pro Lys Gly Arg Glu Ile Leu Glu Leu Val Gln 
                165                 170                 175     


Lys Gly Ile Pro Val Thr Met Thr Ile Gly Val Gly Thr Arg His Val 
            180                 185                 190         


Gln Glu Phe Ile Ser Gly Gln Ser Val Val Phe Val Ala Ile Ala Phe 
        195                 200                 205             


Ile Thr Met Met Ile Ile Ser Leu Ala Trp Leu Ile Phe Tyr Tyr Ile 
    210                 215                 220                 


Gln Arg Phe Leu Tyr Thr Gly Ser Gln Ile Gly Ser Gln Ser His Arg 
225                 230                 235                 240 


Lys Glu Thr Lys Lys Val Ile Gly Gln Leu Leu Leu His Thr Val Lys 
                245                 250                 255     


His Gly Glu Lys Gly Ile Asp Val Asp Ala Glu Asn Cys Ala Val Cys 
            260                 265                 270         


Ile Glu Asn Phe Lys Val Lys Asp Ile Ile Arg Ile Leu Pro Cys Lys 
        275                 280                 285             


His Ile Phe His Arg Ile Cys Ile Asp Pro Trp Leu Leu Asp His Arg 
    290                 295                 300                 


Thr Cys Pro Met Cys Lys Leu Asp Val Ile Lys Ala Leu Gly Tyr Trp 
305                 310                 315                 320 


Gly Glu Pro Gly Asp Val Gln Glu Met Pro Ala Pro Glu Ser Pro Pro 
                325                 330                 335     


Gly Arg Asp Pro Ala Ala Asn Leu Ser Leu Ala Leu Pro Asp Asp Asp 
            340                 345                 350         


Gly Ser Asp Asp Ser Ser Pro Pro Ser Ala Ser Pro Ala Glu Ser Glu 
        355                 360                 365             


Pro Gln Cys Asp Pro Ser Phe Lys Gly Asp Ala Gly Glu Asn Thr Ala 
    370                 375                 380                 


Leu Leu Glu Ala Gly Arg Ser Asp Ser Arg His Gly Gly Pro Ile Ser 
385                 390                 395                 400 


<210>  20
<211>  1203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  20
atggcgtggc ggcggcgcga agccagcgtc ggggctcgcg gcgtgttggc tctggcgttg       60

ctcgccctgg ccctgtgcgt gcccggggcc cggggccggg ctctcgagtg gttctcggcc      120

gtggtaaaca tcgagtacgt ggacccgcag accaacctga cggtgtggag cgtctcggag      180

agtggccgct tcggcgacag ctcgcccaag gagggcgcgc atggcctggt gggcgtcccg      240

tgggcgcccg gcggagacct cgagggctgc gcgcccgaca cgcgcttctt cgtgcccgag      300

cccggcggcc gaggggccgc gccctgggtc gccctggtgg ctcgtggggg ctgcaccttc      360

aaggacaagg tgctggtggc ggcgcggagg aacgcctcgg ccgtcgtcct ctacaatgag      420

gagcgctacg ggaacatcac cttgcccatg tctcacgcgg gaacaggaaa tatagtggtc      480

attatgatta gctatccaaa aggaagagaa attttggagc tggtgcaaaa aggaattcca      540

gtaacgatga ccataggggt tggcacccgg catgtacagg agttcatcag cggtcagtct      600

gtggtgtttg tggccattgc cttcatcacc atgatgatta tctcgttagc ctggctaata      660

ttttactata tacagcgttt cctatatact ggctctcaga ttggaagtca gagccataga      720

aaagaaacta agaaagttat tggccagctt ctacttcata ctgtaaagca tggagaaaag      780

ggaattgatg ttgatgctga aaattgtgca gtgtgtattg aaaatttcaa agtaaaggat      840

attattagaa ttctgccatg caagcatatt tttcatagaa tatgcattga cccatggctt      900

ttggatcacc gaacatgtcc aatgtgtaaa cttgatgtca tcaaagccct aggatattgg      960

ggagagcctg gggatgtaca ggagatgcct gctccagaat ctcctcctgg aagggatcca     1020

gctgcaaatt tgagtctagc tttaccagat gatgacggaa gtgatgacag cagtccacca     1080

tcagcctccc ctgctgaatc tgagccacag tgtgatccca gctttaaagg agatgcagga     1140

gaaaatacgg cattgctaga agccggcagg agtgactctc ggcatggagg acccatctcc     1200

tag                                                                   1203


<210>  21
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Ala Lys Glu Lys Leu Glu Ala Val Leu Asn Val Ala Leu Arg 
1               5                   10                  15      


Val Pro Ser Ile Met Leu Leu Asp Val Leu Tyr Arg Trp Asp Val Ser 
            20                  25                  30          


Ser Phe Phe Gln Gln Ile Gln Arg Ser Ser Leu Ser Asn Asn Pro Leu 
        35                  40                  45              


Phe Gln Tyr Lys Tyr Leu Ala Leu Asn Met His Tyr Val Gly Tyr Ile 
    50                  55                  60                  


Leu Ser Val Val Leu Leu Thr Leu Pro Arg Gln His Leu Val Gln Leu 
65                  70                  75                  80  


Tyr Leu Tyr Phe Leu Thr Ala Leu Leu Leu Tyr Ala Gly His Gln Ile 
                85                  90                  95      


Ser Arg Asp Tyr Val Arg Ser Glu Leu Glu Phe Ala Tyr Glu Gly Pro 
            100                 105                 110         


Met Tyr Leu Glu Pro Leu Ser Met Asn Arg Phe Thr Thr Ala Leu Ile 
        115                 120                 125             


Gly Gln Leu Val Val Cys Thr Leu Cys Ser Cys Val Met Lys Thr Lys 
    130                 135                 140                 


Gln Ile Trp Leu Phe Ser Ala His Met Leu Pro Leu Leu Ala Arg Leu 
145                 150                 155                 160 


Cys Leu Val Pro Leu Glu Thr Ile Val Ile Ile Asn Lys Phe Ala Met 
                165                 170                 175     


Ile Phe Thr Gly Leu Glu Val Leu Tyr Phe Leu Gly Ser Asn Leu Leu 
            180                 185                 190         


Val Pro Tyr Asn Leu Ala Lys Ser Ala Tyr Arg Glu Leu Val Gln Val 
        195                 200                 205             


Val Glu Val Tyr Gly Leu Leu Ala Leu Gly Met Ser Leu Trp Asn Gln 
    210                 215                 220                 


Leu Val Val Pro Val Leu Phe Met Val Phe Trp Leu Val Leu Phe Ala 
225                 230                 235                 240 


Leu Gln Ile Tyr Ser Tyr Phe Ser Thr Arg Asp Gln Pro Ala Ser Arg 
                245                 250                 255     


Glu Arg Leu Leu Phe Leu Phe Leu Thr Ser Ile Ala Glu Cys Cys Ser 
            260                 265                 270         


Thr Pro Tyr Ser Leu Leu Gly Leu Val Phe Thr Val Ser Phe Val Ala 
        275                 280                 285             


Leu Gly Val Leu Thr Leu Cys Lys Phe Tyr Leu Gln Gly Tyr Arg Ala 
    290                 295                 300                 


Phe Met Asn Asp Pro Ala Met Asn Arg Gly Met Thr Glu Gly Val Thr 
305                 310                 315                 320 


Leu Leu Ile Leu Ala Val Gln Thr Gly Leu Ile Glu Leu Gln Val Val 
                325                 330                 335     


His Arg Ala Phe Leu Leu Ser Ile Ile Leu Phe Ile Val Val Ala Ser 
            340                 345                 350         


Ile Leu Gln Ser Met Leu Glu Ile Ala Asp Pro Ile Val Leu Ala Leu 
        355                 360                 365             


Gly Ala Ser Arg Asp Lys Ser Leu Trp Lys His Phe Arg Ala Val Ser 
    370                 375                 380                 


Leu Cys Leu Phe Leu Leu Val Phe Pro Ala Tyr Met Ala Tyr Met Ile 
385                 390                 395                 400 


Cys Gln Phe Phe His Met Asp Phe Trp Leu Leu Ile Ile Ile Ser Ser 
                405                 410                 415     


Ser Ile Leu Thr Ser Leu Gln Val Leu Gly Thr Leu Phe Ile Tyr Val 
            420                 425                 430         


Leu Phe Met Val Glu Glu Phe Arg Lys Glu Pro Val Glu Asn Met Asp 
        435                 440                 445             


Asp Val Ile Tyr Tyr Val Asn Gly Thr Tyr Arg Leu Leu Glu Phe Leu 
    450                 455                 460                 


Val Ala Leu Cys Val Val Ala Tyr Gly Val Ser Glu Thr Ile Phe Gly 
465                 470                 475                 480 


Glu Trp Thr Val Met Gly Ser Met Ile Ile Phe Ile His Ser Tyr Tyr 
                485                 490                 495     


Asn Val Trp Leu Arg Ala Gln Leu Gly Trp Lys Ser Phe Leu Leu Arg 
            500                 505                 510         


Arg Asp Ala Val Asn Lys Ile Lys Ser Leu Pro Ile Ala Thr Lys Glu 
        515                 520                 525             


Gln Leu Glu Lys His Asn Asp Ile Cys Ala Ile Cys Tyr Gln Asp Met 
    530                 535                 540                 


Lys Ser Ala Val Ile Thr Pro Cys Ser His Phe Phe His Ala Gly Cys 
545                 550                 555                 560 


Leu Lys Lys Trp Leu Tyr Val Gln Glu Thr Cys Pro Leu Cys His Cys 
                565                 570                 575     


His Leu Lys Asn Ser Ser Gln Leu Pro Gly Leu Gly Thr Glu Pro Val 
            580                 585                 590         


Leu Gln Pro His Ala Gly Ala Glu Gln Asn Val Met Phe Gln Glu Gly 
        595                 600                 605             


Thr Glu Pro Pro Gly Gln Glu His Thr Pro Gly Thr Arg Ile Gln Glu 
    610                 615                 620                 


Gly Ser Arg Asp Asn Asn Glu Tyr Ile Ala Arg Arg Pro Asp Asn Gln 
625                 630                 635                 640 


Glu Gly Ala Phe Asp Pro Lys Glu Tyr Pro His Ser Ala Lys Asp Glu 
                645                 650                 655     


Ala His Pro Val Glu Ser Ala 
            660             


<210>  22
<211>  1992
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  22
atggctgcaa aggagaaact ggaggcagtg ttaaatgtgg ccctgagggt gccaagcatc       60

atgctgttgg atgtcctgta cagatgggat gtcagctcct ttttccagca gatccaaaga      120

agtagcctta gtaataaccc tcttttccag tataagtatt tggctcttaa tatgcattat      180

gtaggttata tcttaagtgt ggtgctgcta acattgccca ggcagcatct ggttcagctt      240

tatctatatt ttttgactgc tctgctcctc tatgctggac atcaaatttc cagggactat      300

gttcggagtg aactggagtt tgcctatgag ggaccaatgt atttagaacc tctctctatg      360

aatcggttta ccacagcctt aataggtcag ttggtggtgt gtactttatg ctcctgtgtc      420

atgaaaacaa agcagatttg gctgttttca gctcacatgc ttcctctgct agcacgactc      480

tgccttgttc ctttggagac aattgttatc atcaataaat ttgctatgat ttttactgga      540

ttggaagttc tctattttct tgggtctaat cttttggtac cttataacct tgctaaatct      600

gcatacagag aattggttca ggtagtggag gtatatggcc ttctcgcctt gggaatgtcc      660

ctgtggaatc aactggtagt ccctgttctt ttcatggttt tctggctcgt cttatttgct      720

cttcagattt actcctattt cagtactcga gatcagcctg catcacgtga gaggcttctt      780

ttcctttttc tgacaagtat tgcggaatgc tgcagcactc cttactctct tttgggtttg      840

gtcttcacgg tttcttttgt tgccttgggt gttctcacac tctgcaagtt ttacttgcag      900

ggttatcgag ctttcatgaa tgatcctgcc atgaatcggg gcatgacaga aggagtaacg      960

ctgttaatcc tggcagtgca gactgggctg atagaactgc aggttgttca tcgggcattc     1020

ttgctcagta ttatcctttt cattgtcgta gcttctatcc tacagtctat gttagaaatt     1080

gcagatccta ttgttttggc actgggagca tctagagaca agagcttgtg gaaacacttc     1140

cgtgctgtaa gcctttgttt atttttattg gtattccctg cttatatggc ttatatgatt     1200

tgccagtttt tccacatgga tttttggctt cttatcatta tttccagcag cattcttacc     1260

tctcttcagg ttctgggaac actttttatt tatgtcttat ttatggttga ggaattcaga     1320

aaagagccag tggaaaacat ggatgatgtc atctactatg tgaatggcac ttaccgcctg     1380

ctggagtttc ttgtggccct ctgtgtggtg gcctatggcg tctcagagac catctttgga     1440

gaatggacag tgatgggctc aatgatcatc ttcattcatt cctactataa cgtgtggctt     1500

cgggcccagc tggggtggaa gagctttctt ctccgcaggg atgctgtgaa taagattaaa     1560

tcgttaccca ttgctacgaa agagcagctt gagaaacaca atgatatttg tgccatctgt     1620

tatcaggaca tgaaatctgc tgtgatcacg ccttgcagtc attttttcca tgcaggctgt     1680

cttaagaaat ggctgtatgt ccaggagacc tgccctctgt gccactgcca tctgaaaaac     1740

tcctcccagc ttccaggatt aggaactgag ccagttctac agcctcatgc tggagctgag     1800

caaaacgtca tgtttcagga aggtactgaa cccccaggcc aggagcatac tccagggacc     1860

aggatacagg aaggttccag ggacaataat gagtacattg ccagacgacc agataaccag     1920

gaaggggctt ttgaccccaa agaatatcct cacagtgcga aagatgaagc acatcctgtt     1980

gaatcagcct ag                                                         1992


<210>  23
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Pro Leu Phe Leu Leu Ser Leu Pro Thr Pro Pro Ser Ala Ser Gly 
1               5                   10                  15      


His Glu Arg Arg Gln Arg Pro Glu Ala Lys Thr Ser Gly Ser Glu Lys 
            20                  25                  30          


Lys Tyr Leu Arg Ala Met Gln Ala Asn Arg Ser Gln Leu His Ser Pro 
        35                  40                  45              


Pro Gly Thr Gly Ser Ser Glu Asp Ala Ser Thr Pro Gln Cys Val His 
    50                  55                  60                  


Thr Arg Leu Thr Gly Glu Gly Ser Cys Pro His Ser Gly Asp Val His 
65                  70                  75                  80  


Ile Gln Ile Asn Ser Ile Pro Lys Glu Cys Ala Glu Asn Ala Ser Ser 
                85                  90                  95      


Arg Asn Ile Arg Ser Gly Val His Ser Cys Ala His Gly Cys Val His 
            100                 105                 110         


Ser Arg Leu Arg Gly His Ser His Ser Glu Ala Arg Leu Thr Asp Asp 
        115                 120                 125             


Thr Ala Ala Glu Ser Gly Asp His Gly Ser Ser Ser Phe Ser Glu Phe 
    130                 135                 140                 


Arg Tyr Leu Phe Lys Trp Leu Gln Lys Ser Leu Pro Tyr Ile Leu Ile 
145                 150                 155                 160 


Leu Ser Val Lys Leu Val Met Gln His Ile Thr Gly Ile Ser Leu Gly 
                165                 170                 175     


Ile Gly Leu Leu Thr Thr Phe Met Tyr Ala Asn Lys Ser Ile Val Asn 
            180                 185                 190         


Gln Val Phe Leu Arg Glu Arg Ser Ser Lys Ile Gln Cys Ala Trp Leu 
        195                 200                 205             


Leu Val Phe Leu Ala Gly Ser Ser Val Leu Leu Tyr Tyr Thr Phe His 
    210                 215                 220                 


Ser Gln Ser Leu Tyr Tyr Ser Leu Ile Phe Leu Asn Pro Thr Leu Asp 
225                 230                 235                 240 


His Leu Ser Phe Trp Glu Val Phe Trp Ile Val Gly Ile Thr Asp Phe 
                245                 250                 255     


Ile Leu Lys Phe Phe Phe Met Gly Leu Lys Cys Leu Ile Leu Leu Val 
            260                 265                 270         


Pro Ser Phe Ile Met Pro Phe Lys Ser Lys Gly Tyr Trp Tyr Met Leu 
        275                 280                 285             


Leu Glu Glu Leu Cys Gln Tyr Tyr Arg Thr Phe Val Pro Ile Pro Val 
    290                 295                 300                 


Trp Phe Arg Tyr Leu Ile Ser Tyr Gly Glu Phe Gly Asn Val Thr Arg 
305                 310                 315                 320 


Trp Ser Leu Gly Ile Leu Leu Ala Leu Leu Tyr Leu Ile Leu Lys Leu 
                325                 330                 335     


Leu Glu Phe Phe Gly His Leu Arg Thr Phe Arg Gln Val Leu Arg Ile 
            340                 345                 350         


Phe Phe Thr Gln Pro Ser Tyr Gly Val Ala Ala Ser Lys Arg Gln Cys 
        355                 360                 365             


Ser Asp Val Asp Asp Ile Cys Ser Ile Cys Gln Ala Glu Phe Gln Lys 
    370                 375                 380                 


Pro Ile Leu Leu Ile Cys Gln His Ile Phe Cys Glu Glu Cys Met Thr 
385                 390                 395                 400 


Leu Trp Phe Asn Arg Glu Lys Thr Cys Pro Leu Cys Arg Thr Val Ile 
                405                 410                 415     


Ser Asp His Ile Asn Lys Trp Lys Asp Gly Ala Thr Ser Ser His Leu 
            420                 425                 430         


Gln Ile Tyr 
        435 


<210>  24
<211>  1308
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  24
atgccgctgt tcttgctgtc gctcccgaca cctccgtccg cttctggtca tgagaggaga       60

cagaggcctg aagcaaagac atctgggtca gagaaaaagt atttaagggc catgcaagcc      120

aatcgtagcc aactgcacag tcctccagga actggaagca gtgaggatgc ctcaacccct      180

cagtgtgtcc acacaagatt gacaggagag ggttcttgcc ctcattctgg agatgttcat      240

atccagataa actccatacc taaagaatgt gcagaaaatg caagctccag aaatataagg      300

tcaggtgtcc atagctgtgc ccatggatgt gtacacagtc gcttacgggg tcactcccac      360

agtgaagcaa ggctgactga tgatactgcc gcagaatctg gagatcatgg tagtagctcc      420

ttctcagaat tccgctatct cttcaagtgg ctgcaaaaaa gtcttccata tattttgatt      480

ctgagcgtca aacttgttat gcagcatata acaggaattt ctcttggaat tgggctgcta      540

acaactttta tgtatgcaaa caaaagcatt gtaaatcagg tttttctaag agaaaggtcc      600

tcaaagattc agtgtgcttg gttactggta ttcttagcag gatcttctgt tcttttatat      660

tacacctttc attctcagtc actttattac agcttaattt ttttaaatcc tactttggac      720

catttgagct tctgggaagt attttggatt gttggaatta cagacttcat tctgaaattc      780

tttttcatgg gcttaaaatg ccttatttta ttggtgcctt ctttcatcat gccttttaaa      840

tctaagggtt actggtatat gcttttagaa gaattgtgtc aatactaccg aacttttgtt      900

cccataccag tttggtttcg ctaccttata agctatgggg agtttggtaa cgtaactaga      960

tggagtcttg ggatactgct ggctttactc tacctcatat taaaactttt ggaatttttt     1020

gggcatctga gaactttcag acaggtttta cgaatatttt ttacacaacc aagttatgga     1080

gtggctgcca gcaagagaca gtgttcagat gtggatgata tttgttcaat atgtcaagct     1140

gaatttcaga agccaattct tctcatttgt cagcatatat tttgtgaaga gtgcatgacc     1200

ttatggttta acagagagaa aacatgtcca ctctgcagaa ctgtgatttc agaccatata     1260

aacaaatgga aggatggagc cacttcatca caccttcaaa tatattaa                  1308


<210>  25
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  25

Met His Pro Ala Ala Phe Pro Leu Pro Val Val Val Ala Ala Val Leu 
1               5                   10                  15      


Trp Gly Ala Ala Pro Thr Arg Gly Leu Ile Arg Ala Thr Ser Asp His 
            20                  25                  30          


Asn Ala Ser Met Asp Phe Ala Asp Leu Pro Ala Leu Phe Gly Ala Thr 
        35                  40                  45              


Leu Ser Gln Glu Gly Leu Gln Gly Phe Leu Val Glu Ala His Pro Asp 
    50                  55                  60                  


Asn Ala Cys Ser Pro Ile Ala Pro Pro Pro Pro Ala Pro Val Asn Gly 
65                  70                  75                  80  


Ser Val Phe Ile Ala Leu Leu Arg Arg Phe Asp Cys Asn Phe Asp Leu 
                85                  90                  95      


Lys Val Leu Asn Ala Gln Lys Ala Gly Tyr Gly Ala Ala Val Val His 
            100                 105                 110         


Asn Val Asn Ser Asn Glu Leu Leu Asn Met Val Trp Asn Ser Glu Glu 
        115                 120                 125             


Ile Gln Gln Gln Ile Trp Ile Pro Ser Val Phe Ile Gly Glu Arg Ser 
    130                 135                 140                 


Ser Glu Tyr Leu Arg Ala Leu Phe Val Tyr Glu Lys Gly Ala Arg Val 
145                 150                 155                 160 


Leu Leu Val Pro Asp Asn Thr Phe Pro Leu Gly Tyr Tyr Leu Ile Pro 
                165                 170                 175     


Phe Thr Gly Ile Val Gly Leu Leu Val Leu Ala Met Gly Ala Val Met 
            180                 185                 190         


Ile Ala Arg Cys Ile Gln His Arg Lys Arg Leu Gln Arg Asn Arg Leu 
        195                 200                 205             


Thr Lys Glu Gln Leu Lys Gln Ile Pro Thr His Asp Tyr Gln Lys Gly 
    210                 215                 220                 


Asp Gln Tyr Asp Val Cys Ala Ile Cys Leu Asp Glu Tyr Glu Asp Gly 
225                 230                 235                 240 


Asp Lys Leu Arg Val Leu Pro Cys Ala His Ala Tyr His Ser Arg Cys 
                245                 250                 255     


Val Asp Pro Trp Leu Thr Gln Thr Arg Lys Thr Cys Pro Ile Cys Lys 
            260                 265                 270         


Gln Pro Val His Arg Gly Pro Gly Asp Glu Asp Gln Glu Glu Glu Thr 
        275                 280                 285             


Gln Gly Gln Glu Glu Gly Asp Glu Gly Glu Pro Arg Asp His Pro Ala 
    290                 295                 300                 


Ser Glu Arg Thr Pro Leu Leu Gly Ser Ser Pro Thr Leu Pro Thr Ser 
305                 310                 315                 320 


Phe Gly Ser Leu Ala Pro Ala Pro Leu Val Phe Pro Gly Pro Ser Thr 
                325                 330                 335     


Asp Pro Pro Leu Ser Pro Pro Ser Ser Pro Val Ile Leu Val 
            340                 345                 350 


<210>  26
<211>  1053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  26
atgcaccctg cagccttccc gcttcctgtg gttgtggccg ctgtgctgtg gggagcggcc       60

ccgacccggg ggctcattcg agcgacctcg gaccacaatg ccagcatgga ctttgcagac      120

cttccagctc tgtttggggc taccttgagc caggagggcc tccaggggtt ccttgtggag      180

gctcacccag acaatgcctg cagccccatt gccccaccac ccccagcccc ggtcaatggg      240

tcagtcttta ttgcgctgct tcgaagattc gactgcaact ttgacctcaa ggtcctaaat      300

gcccagaagg ctggatatgg tgccgctgta gtacacaatg tgaattccaa tgaacttctg      360

aacatggtgt ggaatagtga ggaaatccag cagcagatct ggatcccgtc tgtatttatt      420

ggggagagaa gctccgagta cctgcgtgcc ctctttgtct acgagaaggg ggctcgggtg      480

cttctggttc cagacaatac cttccccttg ggctattacc tcatcccttt cacagggatt      540

gtgggactgc tggttttggc catgggagca gtaatgatag ctcgttgtat ccagcaccgg      600

aaacggctcc agcggaatcg acttaccaaa gagcaactga aacagattcc tacacatgac      660

tatcagaagg gagaccagta tgatgtctgt gccatttgcc tggatgaata tgaggatggg      720

gacaagctgc gggtactccc ctgtgctcat gcctaccaca gccgctgcgt ggacccctgg      780

ctcactcaga cccggaagac ctgccccatt tgcaagcagc ctgttcatcg gggtcctggg      840

gacgaagacc aagaggaaga aactcaaggg caagaggagg gtgatgaagg ggagccaagg      900

gaccaccctg cctcagaaag gaccccactt ttgggttcta gccccactct tcccacctcc      960

tttggttcct tagccccagc tccccttgtt tttcctgggc cttcaacaga tcccccactg     1020

tcccctccct cttcccctgt tatcctggtc taa                                  1053


<210>  27
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Cys Ala Gly Arg Ala Gly Pro Ala Arg Leu Ala Ala Leu Ala 
1               5                   10                  15      


Leu Leu Thr Cys Ser Leu Trp Pro Ala Arg Ala Asp Asn Ala Ser Gln 
            20                  25                  30          


Glu Tyr Tyr Thr Ala Leu Ile Asn Val Thr Val Gln Glu Pro Gly Arg 
        35                  40                  45              


Gly Ala Pro Leu Thr Phe Arg Ile Asp Arg Gly Arg Tyr Gly Leu Asp 
    50                  55                  60                  


Ser Pro Lys Ala Glu Val Arg Gly Gln Val Leu Ala Pro Leu Pro Leu 
65                  70                  75                  80  


His Gly Val Ala Asp His Leu Gly Cys Asp Pro Gln Thr Arg Phe Phe 
                85                  90                  95      


Val Pro Pro Asn Ile Lys Gln Trp Ile Ala Leu Leu Gln Arg Gly Asn 
            100                 105                 110         


Cys Thr Phe Lys Glu Lys Ile Ser Arg Ala Ala Phe His Asn Ala Val 
        115                 120                 125             


Ala Val Val Ile Tyr Asn Asn Lys Ser Lys Glu Glu Pro Val Thr Met 
    130                 135                 140                 


Thr His Pro Gly Thr Gly Asp Ile Ile Ala Val Met Ile Thr Glu Leu 
145                 150                 155                 160 


Arg Gly Lys Asp Ile Leu Ser Tyr Leu Glu Lys Asn Ile Ser Val Gln 
                165                 170                 175     


Met Thr Ile Ala Val Gly Thr Arg Met Pro Pro Lys Asn Phe Ser Arg 
            180                 185                 190         


Gly Ser Leu Val Phe Val Ser Ile Ser Phe Ile Val Leu Met Ile Ile 
        195                 200                 205             


Ser Ser Ala Trp Leu Ile Phe Tyr Phe Ile Gln Lys Ile Arg Tyr Thr 
    210                 215                 220                 


Asn Ala Arg Asp Arg Asn Gln Arg Arg Leu Gly Asp Ala Ala Lys Lys 
225                 230                 235                 240 


Ala Ile Ser Lys Leu Thr Thr Arg Thr Val Lys Lys Gly Asp Lys Glu 
                245                 250                 255     


Thr Asp Pro Asp Phe Asp His Cys Ala Val Cys Ile Glu Ser Tyr Lys 
            260                 265                 270         


Gln Asn Asp Val Val Arg Ile Leu Pro Cys Lys His Val Phe His Lys 
        275                 280                 285             


Ser Cys Val Asp Pro Trp Leu Ser Glu His Cys Thr Cys Pro Met Cys 
    290                 295                 300                 


Lys Leu Asn Ile Leu Lys Ala Leu Gly Ile Val Pro Asn Leu Pro Cys 
305                 310                 315                 320 


Thr Asp Asn Val Ala Phe Asp Met Glu Arg Leu Thr Arg Thr Gln Ala 
                325                 330                 335     


Val Asn Arg Arg Ser Ala Leu Gly Asp Leu Ala Gly Asp Asn Ser Leu 
            340                 345                 350         


Gly Leu Glu Pro Leu Arg Thr Ser Gly Ile Ser Pro Leu Pro Gln Asp 
        355                 360                 365             


Gly Glu Leu Thr Pro Arg Thr Gly Glu Ile Asn Ile Ala Val Thr Lys 
    370                 375                 380                 


Glu Trp Phe Ile Ile Ala Ser Phe Gly Leu Leu Ser Ala Leu Thr Leu 
385                 390                 395                 400 


Cys Tyr Met Ile Ile Arg Ala Thr Ala Ser Leu Asn Ala Asn Glu Val 
                405                 410                 415     


Glu Trp Phe 
            


<210>  28
<211>  1260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  28
atgagctgcg cggggcgggc gggccctgcc cggctcgccg cgctcgccct gctgacctgc       60

agcctgtggc cggcacgggc agacaacgcg agccaggagt actacacggc gctcatcaac      120

gtgacggtgc aggagcccgg ccgcggcgcc ccgctcacgt ttcgcatcga ccgcgggcgc      180

tacgggcttg actcccccaa ggccgaggtc cgcggccagg tgctggcgcc gctgcccctc      240

cacggagttg ctgatcatct gggctgtgat ccacaaaccc ggttctttgt ccctcctaat      300

atcaaacagt ggattgcctt gctgcagagg ggaaactgca cgtttaaaga gaaaatatca      360

cgggccgctt tccacaatgc agttgctgta gtcatctaca ataataaatc caaagaggag      420

ccagttacca tgactcatcc aggcactgga gatattattg ctgtcatgat aacagaattg      480

aggggtaagg atattttgag ttatctggag aaaaacatct ctgtacaaat gacaatagct      540

gttggaactc gaatgccacc gaagaacttc agccgtggct ctctagtctt cgtgtcaata      600

tcctttattg ttttgatgat tatttcttca gcatggctca tattctactt cattcagaag      660

atcaggtaca caaatgcacg cgacaggaac cagcgtcgtc tcggagatgc agccaagaaa      720

gccatcagta aattgacaac caggacagta aagaagggtg acaaggaaac tgacccagac      780

tttgatcatt gtgcagtctg catagagagc tataagcaga atgatgtcgt ccgaattctc      840

ccctgcaagc atgttttcca caaatcctgc gtggatccct ggcttagtga acattgtacc      900

tgtcctatgt gcaaacttaa tatattgaag gccctgggaa ttgtgccgaa tttgccatgt      960

actgataacg tagcattcga tatggaaagg ctcaccagaa cccaagctgt taaccgaaga     1020

tcagccctcg gcgacctcgc cggcgacaac tcccttggcc ttgagccact tcgaacttcg     1080

gggatctcac ctcttcctca ggatggggag ctcactccga gaacaggaga aatcaacatt     1140

gcagtaacaa aagaatggtt tattattgcc agttttggcc tcctcagtgc cctcacactc     1200

tgctacatga tcatcagagc cacagctagc ttgaatgcta atgaggtaga atggttttga     1260


<210>  29
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Pro Pro Pro Gly Ala Gly Val Ser Cys Arg Gly Gly Cys Gly 
1               5                   10                  15      


Phe Ser Arg Leu Leu Ala Trp Cys Phe Leu Leu Ala Leu Ser Pro Gln 
            20                  25                  30          


Ala Pro Gly Ser Arg Gly Ala Glu Ala Val Trp Thr Ala Tyr Leu Asn 
        35                  40                  45              


Val Ser Trp Arg Val Pro His Thr Gly Val Asn Arg Thr Val Trp Glu 
    50                  55                  60                  


Leu Ser Glu Glu Gly Val Tyr Gly Gln Asp Ser Pro Leu Glu Pro Val 
65                  70                  75                  80  


Ala Gly Val Leu Val Pro Pro Asp Gly Pro Gly Ala Leu Asn Ala Cys 
                85                  90                  95      


Asn Pro His Thr Asn Phe Thr Val Pro Thr Val Trp Gly Ser Thr Val 
            100                 105                 110         


Gln Val Ser Trp Leu Ala Leu Ile Gln Arg Gly Gly Gly Cys Thr Phe 
        115                 120                 125             


Ala Asp Lys Ile His Leu Ala Tyr Glu Arg Gly Ala Ser Gly Ala Val 
    130                 135                 140                 


Ile Phe Asn Phe Pro Gly Thr Arg Asn Glu Val Ile Pro Met Ser His 
145                 150                 155                 160 


Pro Gly Ala Val Asp Ile Val Ala Ile Met Ile Gly Asn Leu Lys Gly 
                165                 170                 175     


Thr Lys Ile Leu Gln Ser Ile Gln Arg Gly Ile Gln Val Thr Met Val 
            180                 185                 190         


Ile Glu Val Gly Lys Lys His Gly Pro Trp Val Asn His Tyr Ser Ile 
        195                 200                 205             


Phe Phe Val Ser Val Ser Phe Phe Ile Ile Thr Ala Ala Thr Val Gly 
    210                 215                 220                 


Tyr Phe Ile Phe Tyr Ser Ala Arg Arg Leu Arg Asn Ala Arg Ala Gln 
225                 230                 235                 240 


Ser Arg Lys Gln Arg Gln Leu Lys Ala Asp Ala Lys Lys Ala Ile Gly 
                245                 250                 255     


Arg Leu Gln Leu Arg Thr Leu Lys Gln Gly Asp Lys Glu Ile Gly Pro 
            260                 265                 270         


Asp Gly Asp Ser Cys Ala Val Cys Ile Glu Leu Tyr Lys Pro Asn Asp 
        275                 280                 285             


Leu Val Arg Ile Leu Thr Cys Asn His Ile Phe His Lys Thr Cys Val 
    290                 295                 300                 


Asp Pro Trp Leu Leu Glu His Arg Thr Cys Pro Met Cys Lys Cys Asp 
305                 310                 315                 320 


Ile Leu Lys Ala Leu Gly Ile Glu Val Asp Val Glu Asp Gly Ser Val 
                325                 330                 335     


Ser Leu Gln Val Pro Val Ser Asn Glu Ile Ser Asn Ser Ala Ser Ser 
            340                 345                 350         


His Glu Glu Asp Asn Arg Ser Glu Thr Ala Ser Ser Gly Tyr Ala Ser 
        355                 360                 365             


Val Gln Gly Thr Asp Glu Pro Pro Leu Glu Glu His Val Gln Ser Thr 
    370                 375                 380                 


Asn Glu Ser Leu Gln Leu Val Asn His Glu Ala Asn Ser Val Ala Val 
385                 390                 395                 400 


Asp Val Ile Pro His Val Asp Asn Pro Thr Phe Glu Glu Asp Glu Thr 
                405                 410                 415     


Pro Asn Gln Glu Thr Ala Val Arg Glu Ile Lys Ser 
            420                 425             


<210>  30
<211>  1287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  30
atggggccgc cgcctggggc cggggtctcc tgccgcggtg gctgcggctt ttccagattg       60

ctggcatggt gcttcctgct ggccctgagt ccgcaggcac ccggttcccg gggggctgaa      120

gcagtgtgga ccgcgtacct caacgtgtcc tggcgggttc cgcacacggg agtgaaccgt      180

acggtgtggg agctgagcga ggagggcgtg tacggccagg actcgccgct ggagcctgtg      240

gctggggtcc tggtaccgcc cgacgggccc ggggcgctta acgcctgtaa cccgcacacg      300

aatttcacgg tgcccacggt ttggggaagc accgtgcaag tctcttggtt ggccctcatc      360

caacgcggcg ggggctgcac cttcgcagac aagatccatc tggcttatga gagaggggcg      420

tctggagccg tcatctttaa cttccccggg acccgcaatg aggtcatccc catgtctcac      480

ccgggtgcag tagacattgt tgcaatcatg atcggcaatc tgaaaggcac aaaaattctg      540

caatctattc aaagaggcat acaagtgaca atggtcatag aagtagggaa aaaacatggc      600

ccttgggtga atcactattc aatttttttc gtttctgtgt ccttttttat tattacggcg      660

gcaactgtgg gctattttat cttttattct gctcgaaggc tacggaatgc aagagctcaa      720

agcaggaagc agaggcaatt aaaggcagat gctaaaaaag ctattggaag gcttcaacta      780

cgcacactga aacaaggaga caaggaaatt ggccctgatg gagatagttg tgctgtgtgc      840

attgaattgt ataaaccaaa tgatttggta cgcatcttaa cgtgcaacca tattttccat      900

aagacatgtg ttgacccatg gctgttagaa cacaggactt gccccatgtg caaatgtgac      960

atactcaaag ctttgggaat tgaggtggat gttgaagatg gatcagtgtc tttacaagtc     1020

cctgtatcca atgaaatatc taatagtgcc tcctcccatg aagaggataa tcgcagcgag     1080

accgcatcat ctggatatgc ttcagtacag ggaacagatg aaccgcctct ggaggaacac     1140

gtgcagtcaa caaatgaaag tctacagctg gtaaaccatg aagcaaattc tgtggcagtg     1200

gatgttattc ctcatgttga caacccaacc tttgaagaag acgaaactcc taatcaagag     1260

actgctgttc gagaaattaa atcttaa                                         1287


<210>  31
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210>  32
<211>  1512
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  32
atggaggcgg cggtcgctgc tccgcgtccc cggctgctcc tcctcgtgct ggcggcggcg       60

gcggcggcgg cggcggcgct gctcccgggg gcgacggcgt tacagtgttt ctgccacctc      120

tgtacaaaag acaattttac ttgtgtgaca gatgggctct gctttgtctc tgtcacagag      180

accacagaca aagttataca caacagcatg tgtatagctg aaattgactt aattcctcga      240

gataggccgt ttgtatgtgc accctcttca aaaactgggt ctgtgactac aacatattgc      300

tgcaatcagg accattgcaa taaaatagaa cttccaacta ctgtaaagtc atcacctggc      360

cttggtcctg tggaactggc agctgtcatt gctggaccag tgtgcttcgt ctgcatctca      420

ctcatgttga tggtctatat ctgccacaac cgcactgtca ttcaccatcg agtgccaaat      480

gaagaggacc cttcattaga tcgccctttt atttcagagg gtactacgtt gaaagactta      540

atttatgata tgacaacgtc aggttctggc tcaggtttac cattgcttgt tcagagaaca      600

attgcgagaa ctattgtgtt acaagaaagc attggcaaag gtcgatttgg agaagtttgg      660

agaggaaagt ggcggggaga agaagttgct gttaagatat tctcctctag agaagaacgt      720

tcgtggttcc gtgaggcaga gatttatcaa actgtaatgt tacgtcatga aaacatcctg      780

ggatttatag cagcagacaa taaagacaat ggtacttgga ctcagctctg gttggtgtca      840

gattatcatg agcatggatc cctttttgat tacttaaaca gatacacagt tactgtggaa      900

ggaatgataa aacttgctct gtccacggcg agcggtcttg cccatcttca catggagatt      960

gttggtaccc aaggaaagcc agccattgct catagagatt tgaaatcaaa gaatatcttg     1020

gtaaagaaga atggaacttg ctgtattgca gacttaggac tggcagtaag acatgattca     1080

gccacagata ccattgatat tgctccaaac cacagagtgg gaacaaaaag gtacatggcc     1140

cctgaagttc tcgatgattc cataaatatg aaacattttg aatccttcaa acgtgctgac     1200

atctatgcaa tgggcttagt attctgggaa attgctcgac gatgttccat tggtggaatt     1260

catgaagatt accaactgcc ttattatgat cttgtacctt ctgacccatc agttgaagaa     1320

atgagaaaag ttgtttgtga acagaagtta aggccaaata tcccaaacag atggcagagc     1380

tgtgaagcct tgagagtaat ggctaaaatt atgagagaat gttggtatgc caatggagca     1440

gctaggctta cagcattgcg gattaagaaa acattatcgc aactcagtca acaggaaggc     1500

atcaaaatgt aa                                                         1512


<210>  33
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    210                 215                 220                 


Thr Trp Glu Thr Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His 
225                 230                 235                 240 


Cys Ala Ile Ile Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys 
                245                 250                 255     


Ala Asn Asn Ile Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp 
            260                 265                 270         


Thr Leu Val Gly Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu 
        275                 280                 285             


Lys Gln Asn Thr Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe 
    290                 295                 300                 


Pro Tyr Glu Glu Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser 
305                 310                 315                 320 


Asp Ile Asn Leu Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu 
                325                 330                 335     


Glu Arg Lys Thr Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe 
            340                 345                 350         


His Ala Lys Gly Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser 
        355                 360                 365             


Trp Glu Asp Leu Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala 
    370                 375                 380                 


His Leu His Ser Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile 
385                 390                 395                 400 


Val His Arg Asp Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu 
                405                 410                 415     


Thr Cys Cys Leu Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr 
            420                 425                 430         


Leu Ser Val Asp Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg 
        435                 440                 445             


Tyr Met Ala Pro Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val 
    450                 455                 460                 


Glu Ser Phe Lys Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp 
465                 470                 475                 480 


Glu Met Thr Ser Arg Cys Asn Ala Val Gly Glu Val Lys Asp Tyr Glu 
                485                 490                 495     


Pro Pro Phe Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser Met 
            500                 505                 510         


Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser Phe 
        515                 520                 525             


Trp Leu Asn His Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr Glu 
    530                 535                 540                 


Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val Ala 
545                 550                 555                 560 


Glu Arg Phe Ser Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg Ser 
                565                 570                 575     


Cys Ser Glu Glu Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr Lys 
            580                 585                 590         


<210>  34
<211>  1779
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  34
atgggtcggg ggctgctcag gggcctgtgg ccgctgcaca tcgtcctgtg gacgcgtatc       60

gccagcacga tcccaccgca cgttcagaag tcggatgtgg aaatggaggc ccagaaagat      120

gaaatcatct gccccagctg taataggact gcccatccac tgagacatat taataacgac      180

atgatagtca ctgacaacaa cggtgcagtc aagtttccac aactgtgtaa attttgtgat      240

gtgagatttt ccacctgtga caaccagaaa tcctgcatga gcaactgcag catcacctcc      300

atctgtgaga agccacagga agtctgtgtg gctgtatgga gaaagaatga cgagaacata      360

acactagaga cagtttgcca tgaccccaag ctcccctacc atgactttat tctggaagat      420

gctgcttctc caaagtgcat tatgaaggaa aaaaaaaagc ctggtgagac tttcttcatg      480

tgttcctgta gctctgatga gtgcaatgac aacatcatct tctcagaaga atataacacc      540

agcaatcctg acttgttgct agtcatattt caagtgacag gcatcagcct cctgccacca      600

ctgggagttg ccatatctgt catcatcatc ttctactgct accgcgttaa ccggcagcag      660

aagctgagtt caacctggga aaccggcaag acgcggaagc tcatggagtt cagcgagcac      720

tgtgccatca tcctggaaga tgaccgctct gacatcagct ccacgtgtgc caacaacatc      780

aaccacaaca cagagctgct gcccattgag ctggacaccc tggtggggaa aggtcgcttt      840

gctgaggtct ataaggccaa gctgaagcag aacacttcag agcagtttga gacagtggca      900

gtcaagatct ttccctatga ggagtatgcc tcttggaaga cagagaagga catcttctca      960

gacatcaatc tgaagcatga gaacatactc cagttcctga cggctgagga gcggaagacg     1020

gagttgggga aacaatactg gctgatcacc gccttccacg ccaagggcaa cctacaggag     1080

tacctgacgc ggcatgtcat cagctgggag gacctgcgca agctgggcag ctccctcgcc     1140

cgggggattg ctcacctcca cagtgatcac actccatgtg ggaggcccaa gatgcccatc     1200

gtgcacaggg acctcaagag ctccaatatc ctcgtgaaga acgacctaac ctgctgcctg     1260

tgtgactttg ggctttccct gcgtctggac cctactctgt ctgtggatga cctggctaac     1320

agtgggcagg tgggaactgc aagatacatg gctccagaag tcctagaatc caggatgaat     1380

ttggagaatg ttgagtcctt caagcagacc gatgtctact ccatggctct ggtgctctgg     1440

gaaatgacat ctcgctgtaa tgcagtggga gaagtaaaag attatgagcc tccatttggt     1500

tccaaggtgc gggagcaccc ctgtgtcgaa agcatgaagg acaacgtgtt gagagatcga     1560

gggcgaccag aaattcccag cttctggctc aaccaccagg gcatccagat ggtgtgtgag     1620

acgttgactg agtgctggga ccacgaccca gaggcccgtc tcacagccca gtgtgtggca     1680

gaacgcttca gtgagctgga gcatctggac aggctctcgg ggaggagctg ctcggaggag     1740

aagattcctg aagacggctc cctaaacact accaaatag                            1779


<210>  35
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  36
<211>  3633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  36
atgcgaccct ccgggacggc cggggcagcg ctcctggcgc tgctggctgc gctctgcccg       60

gcgagtcggg ctctggagga aaagaaagtt tgccaaggca cgagtaacaa gctcacgcag      120

ttgggcactt ttgaagatca ttttctcagc ctccagagga tgttcaataa ctgtgaggtg      180

gtccttggga atttggaaat tacctatgtg cagaggaatt atgatctttc cttcttaaag      240

accatccagg aggtggctgg ttatgtcctc attgccctca acacagtgga gcgaattcct      300

ttggaaaacc tgcagatcat cagaggaaat atgtactacg aaaattccta tgccttagca      360

gtcttatcta actatgatgc aaataaaacc ggactgaagg agctgcccat gagaaattta      420

caggaaatcc tgcatggcgc cgtgcggttc agcaacaacc ctgccctgtg caacgtggag      480

agcatccagt ggcgggacat agtcagcagt gactttctca gcaacatgtc gatggacttc      540

cagaaccacc tgggcagctg ccaaaagtgt gatccaagct gtcccaatgg gagctgctgg      600

ggtgcaggag aggagaactg ccagaaactg accaaaatca tctgtgccca gcagtgctcc      660

gggcgctgcc gtggcaagtc ccccagtgac tgctgccaca accagtgtgc tgcaggctgc      720

acaggccccc gggagagcga ctgcctggtc tgccgcaaat tccgagacga agccacgtgc      780

aaggacacct gccccccact catgctctac aaccccacca cgtaccagat ggatgtgaac      840

cccgagggca aatacagctt tggtgccacc tgcgtgaaga agtgtccccg taattatgtg      900

gtgacagatc acggctcgtg cgtccgagcc tgtggggccg acagctatga gatggaggaa      960

gacggcgtcc gcaagtgtaa gaagtgcgaa gggccttgcc gcaaagtgtg taacggaata     1020

ggtattggtg aatttaaaga ctcactctcc ataaatgcta cgaatattaa acacttcaaa     1080

aactgcacct ccatcagtgg cgatctccac atcctgccgg tggcatttag gggtgactcc     1140

ttcacacata ctcctcctct ggatccacag gaactggata ttctgaaaac cgtaaaggaa     1200

atcacagggt ttttgctgat tcaggcttgg cctgaaaaca ggacggacct ccatgccttt     1260

gagaacctag aaatcatacg cggcaggacc aagcaacatg gtcagttttc tcttgcagtc     1320

gtcagcctga acataacatc cttgggatta cgctccctca aggagataag tgatggagat     1380

gtgataattt caggaaacaa aaatttgtgc tatgcaaata caataaactg gaaaaaactg     1440

tttgggacct ccggtcagaa aaccaaaatt ataagcaaca gaggtgaaaa cagctgcaag     1500

gccacaggcc aggtctgcca tgccttgtgc tcccccgagg gctgctgggg cccggagccc     1560

agggactgcg tctcttgccg gaatgtcagc cgaggcaggg aatgcgtgga caagtgcaac     1620

cttctggagg gtgagccaag ggagtttgtg gagaactctg agtgcataca gtgccaccca     1680

gagtgcctgc ctcaggccat gaacatcacc tgcacaggac ggggaccaga caactgtatc     1740

cagtgtgccc actacattga cggcccccac tgcgtcaaga cctgcccggc aggagtcatg     1800

ggagaaaaca acaccctggt ctggaagtac gcagacgccg gccatgtgtg ccacctgtgc     1860

catccaaact gcacctacgg atgcactggg ccaggtcttg aaggctgtcc aacgaatggg     1920

cctaagatcc cgtccatcgc cactgggatg gtgggggccc tcctcttgct gctggtggtg     1980

gccctgggga tcggcctctt catgcgaagg cgccacatcg ttcggaagcg cacgctgcgg     2040

aggctgctgc aggagaggga gcttgtggag cctcttacac ccagtggaga agctcccaac     2100

caagctctct tgaggatctt gaaggaaact gaattcaaaa agatcaaagt gctgggctcc     2160

ggtgcgttcg gcacggtgta taagggactc tggatcccag aaggtgagaa agttaaaatt     2220

cccgtcgcta tcaaggaatt aagagaagca acatctccga aagccaacaa ggaaatcctc     2280

gatgaagcct acgtgatggc cagcgtggac aacccccacg tgtgccgcct gctgggcatc     2340

tgcctcacct ccaccgtgca gctcatcacg cagctcatgc ccttcggctg cctcctggac     2400

tatgtccggg aacacaaaga caatattggc tcccagtacc tgctcaactg gtgtgtgcag     2460

atcgcaaagg gcatgaacta cttggaggac cgtcgcttgg tgcaccgcga cctggcagcc     2520

aggaacgtac tggtgaaaac accgcagcat gtcaagatca cagattttgg gctggccaaa     2580

ctgctgggtg cggaagagaa agaataccat gcagaaggag gcaaagtgcc tatcaagtgg     2640

atggcattgg aatcaatttt acacagaatc tatacccacc agagtgatgt ctggagctac     2700

ggggtgactg tttgggagtt gatgaccttt ggatccaagc catatgacgg aatccctgcc     2760

agcgagatct cctccatcct ggagaaagga gaacgcctcc ctcagccacc catatgtacc     2820

atcgatgtct acatgatcat ggtcaagtgc tggatgatag acgcagatag tcgcccaaag     2880

ttccgtgagt tgatcatcga attctccaaa atggcccgag acccccagcg ctaccttgtc     2940

attcaggggg atgaaagaat gcatttgcca agtcctacag actccaactt ctaccgtgcc     3000

ctgatggatg aagaagacat ggacgacgtg gtggatgccg acgagtacct catcccacag     3060

cagggcttct tcagcagccc ctccacgtca cggactcccc tcctgagctc tctgagtgca     3120

accagcaaca attccaccgt ggcttgcatt gatagaaatg ggctgcaaag ctgtcccatc     3180

aaggaagaca gcttcttgca gcgatacagc tcagacccca caggcgcctt gactgaggac     3240

agcatagacg acaccttcct cccagtgcct gaatacataa accagtccgt tcccaaaagg     3300

cccgctggct ctgtgcagaa tcctgtctat cacaatcagc ctctgaaccc cgcgcccagc     3360

agagacccac actaccagga cccccacagc actgcagtgg gcaaccccga gtatctcaac     3420

actgtccagc ccacctgtgt caacagcaca ttcgacagcc ctgcccactg ggcccagaaa     3480

ggcagccacc aaattagcct ggacaaccct gactaccagc aggacttctt tcccaaggaa     3540

gccaagccaa atggcatctt taagggctcc acagctgaaa atgcagaata cctaagggtc     3600

gcgccacaaa gcagtgaatt tattggagca tga                                  3633


<210>  37
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  38
<211>  3768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  38
atggagctgg cggccttgtg ccgctggggg ctcctcctcg ccctcttgcc ccccggagcc       60

gcgagcaccc aagtgtgcac cggcacagac atgaagctgc ggctccctgc cagtcccgag      120

acccacctgg acatgctccg ccacctctac cagggctgcc aggtggtgca gggaaacctg      180

gaactcacct acctgcccac caatgccagc ctgtccttcc tgcaggatat ccaggaggtg      240

cagggctacg tgctcatcgc tcacaaccaa gtgaggcagg tcccactgca gaggctgcgg      300

attgtgcgag gcacccagct ctttgaggac aactatgccc tggccgtgct agacaatgga      360

gacccgctga acaataccac ccctgtcaca ggggcctccc caggaggcct gcgggagctg      420

cagcttcgaa gcctcacaga gatcttgaaa ggaggggtct tgatccagcg gaacccccag      480

ctctgctacc aggacacgat tttgtggaag gacatcttcc acaagaacaa ccagctggct      540

ctcacactga tagacaccaa ccgctctcgg gcctgccacc cctgttctcc gatgtgtaag      600

ggctcccgct gctggggaga gagttctgag gattgtcaga gcctgacgcg cactgtctgt      660

gccggtggct gtgcccgctg caaggggcca ctgcccactg actgctgcca tgagcagtgt      720

gctgccggct gcacgggccc caagcactct gactgcctgg cctgcctcca cttcaaccac      780

agtggcatct gtgagctgca ctgcccagcc ctggtcacct acaacacaga cacgtttgag      840

tccatgccca atcccgaggg ccggtataca ttcggcgcca gctgtgtgac tgcctgtccc      900

tacaactacc tttctacgga cgtgggatcc tgcaccctcg tctgccccct gcacaaccaa      960

gaggtgacag cagaggatgg aacacagcgg tgtgagaagt gcagcaagcc ctgtgcccga     1020

gtgtgctatg gtctgggcat ggagcacttg cgagaggtga gggcagttac cagtgccaat     1080

atccaggagt ttgctggctg caagaagatc tttgggagcc tggcatttct gccggagagc     1140

tttgatgggg acccagcctc caacactgcc ccgctccagc cagagcagct ccaagtgttt     1200

gagactctgg aagagatcac aggttaccta tacatctcag catggccgga cagcctgcct     1260

gacctcagcg tcttccagaa cctgcaagta atccggggac gaattctgca caatggcgcc     1320

tactcgctga ccctgcaagg gctgggcatc agctggctgg ggctgcgctc actgagggaa     1380

ctgggcagtg gactggccct catccaccat aacacccacc tctgcttcgt gcacacggtg     1440

ccctgggacc agctctttcg gaacccgcac caagctctgc tccacactgc caaccggcca     1500

gaggacgagt gtgtgggcga gggcctggcc tgccaccagc tgtgcgcccg agggcactgc     1560

tggggtccag ggcccaccca gtgtgtcaac tgcagccagt tccttcgggg ccaggagtgc     1620

gtggaggaat gccgagtact gcaggggctc cccagggagt atgtgaatgc caggcactgt     1680

ttgccgtgcc accctgagtg tcagccccag aatggctcag tgacctgttt tggaccggag     1740

gctgaccagt gtgtggcctg tgcccactat aaggaccctc ccttctgcgt ggcccgctgc     1800

cccagcggtg tgaaacctga cctctcctac atgcccatct ggaagtttcc agatgaggag     1860

ggcgcatgcc agccttgccc catcaactgc acccactcct gtgtggacct ggatgacaag     1920

ggctgccccg ccgagcagag agccagccct ctgacgtcca tcatctctgc ggtggttggc     1980

attctgctgg tcgtggtctt gggggtggtc tttgggatcc tcatcaagcg acggcagcag     2040

aagatccgga agtacacgat gcggagactg ctgcaggaaa cggagctggt ggagccgctg     2100

acacctagcg gagcgatgcc caaccaggcg cagatgcgga tcctgaaaga gacggagctg     2160

aggaaggtga aggtgcttgg atctggcgct tttggcacag tctacaaggg catctggatc     2220

cctgatgggg agaatgtgaa aattccagtg gccatcaaag tgttgaggga aaacacatcc     2280

cccaaagcca acaaagaaat cttagacgaa gcatacgtga tggctggtgt gggctcccca     2340

tatgtctccc gccttctggg catctgcctg acatccacgg tgcagctggt gacacagctt     2400

atgccctatg gctgcctctt agaccatgtc cgggaaaacc gcggacgcct gggctcccag     2460

gacctgctga actggtgtat gcagattgcc aaggggatga gctacctgga ggatgtgcgg     2520

ctcgtacaca gggacttggc cgctcggaac gtgctggtca agagtcccaa ccatgtcaaa     2580

attacagact tcgggctggc tcggctgctg gacattgacg agacagagta ccatgcagat     2640

gggggcaagg tgcccatcaa gtggatggcg ctggagtcca ttctccgccg gcggttcacc     2700

caccagagtg atgtgtggag ttatggtgtg actgtgtggg agctgatgac ttttggggcc     2760

aaaccttacg atgggatccc agcccgggag atccctgacc tgctggaaaa gggggagcgg     2820

ctgccccagc cccccatctg caccattgat gtctacatga tcatggtcaa atgttggatg     2880

attgactctg aatgtcggcc aagattccgg gagttggtgt ctgaattctc ccgcatggcc     2940

agggaccccc agcgctttgt ggtcatccag aatgaggact tgggcccagc cagtcccttg     3000

gacagcacct tctaccgctc actgctggag gacgatgaca tgggggacct ggtggatgct     3060

gaggagtatc tggtacccca gcagggcttc ttctgtccag accctgcccc gggcgctggg     3120

ggcatggtcc accacaggca ccgcagctca tctaccagga gtggcggtgg ggacctgaca     3180

ctagggctgg agccctctga agaggaggcc cccaggtctc cactggcacc ctccgaaggg     3240

gctggctccg atgtatttga tggtgacctg ggaatggggg cagccaaggg gctgcaaagc     3300

ctccccacac atgaccccag ccctctacag cggtacagtg aggaccccac agtacccctg     3360

ccctctgaga ctgatggcta cgttgccccc ctgacctgca gcccccagcc tgaatatgtg     3420

aaccagccag atgttcggcc ccagccccct tcgccccgag agggccctct gcctgctgcc     3480

cgacctgctg gtgccactct ggaaaggccc aagactctct ccccagggaa gaatggggtc     3540

gtcaaagacg tttttgcctt tgggggtgcc gtggagaacc ccgagtactt gacaccccag     3600

ggaggagctg cccctcagcc ccaccctcct cctgccttca gcccagcctt cgacaacctc     3660

tattactggg accaggaccc accagagcgg ggggctccac ccagcacctt caaagggaca     3720

cctacggcag agaacccaga gtacctgggt ctggacgtgc cagtgtga                  3768


<210>  39
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  40
<211>  4029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  40
atgagggcga acgacgctct gcaggtgctg ggcttgcttt tcagcctggc ccggggctcc       60

gaggtgggca actctcaggc agtgtgtcct gggactctga atggcctgag tgtgaccggc      120

gatgctgaga accaatacca gacactgtac aagctctacg agaggtgtga ggtggtgatg      180

gggaaccttg agattgtgct cacgggacac aatgccgacc tctccttcct gcagtggatt      240

cgagaagtga caggctatgt cctcgtggcc atgaatgaat tctctactct accattgccc      300

aacctccgcg tggtgcgagg gacccaggtc tacgatggga agtttgccat cttcgtcatg      360

ttgaactata acaccaactc cagccacgct ctgcgccagc tccgcttgac tcagctcacc      420

gagattctgt cagggggtgt ttatattgag aagaacgata agctttgtca catggacaca      480

attgactgga gggacatcgt gagggaccga gatgctgaga tagtggtgaa ggacaatggc      540

agaagctgtc ccccctgtca tgaggtttgc aaggggcgat gctggggtcc tggatcagaa      600

gactgccaga cattgaccaa gaccatctgt gctcctcagt gtaatggtca ctgctttggg      660

cccaacccca accagtgctg ccatgatgag tgtgccgggg gctgctcagg ccctcaggac      720

acagactgct ttgcctgccg gcacttcaat gacagtggag cctgtgtacc tcgctgtcca      780

cagcctcttg tctacaacaa gctaactttc cagctggaac ccaatcccca caccaagtat      840

cagtatggag gagtttgtgt agccagctgt ccccataact ttgtggtgga tcaaacatcc      900

tgtgtcaggg cctgtcctcc tgacaagatg gaagtagata aaaatgggct caagatgtgt      960

gagccttgtg ggggactatg tcccaaagcc tgtgagggaa caggctctgg gagccgcttc     1020

cagactgtgg actcgagcaa cattgatgga tttgtgaact gcaccaagat cctgggcaac     1080

ctggactttc tgatcaccgg cctcaatgga gacccctggc acaagatccc tgccctggac     1140

ccagagaagc tcaatgtctt ccggacagta cgggagatca caggttacct gaacatccag     1200

tcctggccgc cccacatgca caacttcagt gttttttcca atttgacaac cattggaggc     1260

agaagcctct acaaccgggg cttctcattg ttgatcatga agaacttgaa tgtcacatct     1320

ctgggcttcc gatccctgaa ggaaattagt gctgggcgta tctatataag tgccaatagg     1380

cagctctgct accaccactc tttgaactgg accaaggtgc ttcgggggcc tacggaagag     1440

cgactagaca tcaagcataa tcggccgcgc agagactgcg tggcagaggg caaagtgtgt     1500

gacccactgt gctcctctgg gggatgctgg ggcccaggcc ctggtcagtg cttgtcctgt     1560

cgaaattata gccgaggagg tgtctgtgtg acccactgca actttctgaa tggggagcct     1620

cgagaatttg cccatgaggc cgaatgcttc tcctgccacc cggaatgcca acccatggag     1680

ggcactgcca catgcaatgg ctcgggctct gatacttgtg ctcaatgtgc ccattttcga     1740

gatgggcccc actgtgtgag cagctgcccc catggagtcc taggtgccaa gggcccaatc     1800

tacaagtacc cagatgttca gaatgaatgt cggccctgcc atgagaactg cacccagggg     1860

tgtaaaggac cagagcttca agactgttta ggacaaacac tggtgctgat cggcaaaacc     1920

catctgacaa tggctttgac agtgatagca ggattggtag tgattttcat gatgctgggc     1980

ggcacttttc tctactggcg tgggcgccgg attcagaata aaagggctat gaggcgatac     2040

ttggaacggg gtgagagcat agagcctctg gaccccagtg agaaggctaa caaagtcttg     2100

gccagaatct tcaaagagac agagctaagg aagcttaaag tgcttggctc gggtgtcttt     2160

ggaactgtgc acaaaggagt gtggatccct gagggtgaat caatcaagat tccagtctgc     2220

attaaagtca ttgaggacaa gagtggacgg cagagttttc aagctgtgac agatcatatg     2280

ctggccattg gcagcctgga ccatgcccac attgtaaggc tgctgggact atgcccaggg     2340

tcatctctgc agcttgtcac tcaatatttg cctctgggtt ctctgctgga tcatgtgaga     2400

caacaccggg gggcactggg gccacagctg ctgctcaact ggggagtaca aattgccaag     2460

ggaatgtact accttgagga acatggtatg gtgcatagaa acctggctgc ccgaaacgtg     2520

ctactcaagt cacccagtca ggttcaggtg gcagattttg gtgtggctga cctgctgcct     2580

cctgatgata agcagctgct atacagtgag gccaagactc caattaagtg gatggccctt     2640

gagagtatcc actttgggaa atacacacac cagagtgatg tctggagcta tggtgtgaca     2700

gtttgggagt tgatgacctt cggggcagag ccctatgcag ggctacgatt ggctgaagta     2760

ccagacctgc tagagaaggg ggagcggttg gcacagcccc agatctgcac aattgatgtc     2820

tacatggtga tggtcaagtg ttggatgatt gatgagaaca ttcgcccaac ctttaaagaa     2880

ctagccaatg agttcaccag gatggcccga gacccaccac ggtatctggt cataaagaga     2940

gagagtgggc ctggaatagc ccctgggcca gagccccatg gtctgacaaa caagaagcta     3000

gaggaagtag agctggagcc agaactagac ctagacctag acttggaagc agaggaggac     3060

aacctggcaa ccaccacact gggctccgcc ctcagcctac cagttggaac acttaatcgg     3120

ccacgtggga gccagagcct tttaagtcca tcatctggat acatgcccat gaaccagggt     3180

aatcttgggg agtcttgcca ggagtctgca gtttctggga gcagtgaacg gtgcccccgt     3240

ccagtctctc tacacccaat gccacgggga tgcctggcat cagagtcatc agaggggcat     3300

gtaacaggct ctgaggctga gctccaggag aaagtgtcaa tgtgtaggag ccggagcagg     3360

agccggagcc cacggccacg cggagatagc gcctaccatt cccagcgcca cagtctgctg     3420

actcctgtta ccccactctc cccacccggg ttagaggaag aggatgtcaa cggttatgtc     3480

atgccagata cacacctcaa aggtactccc tcctcccggg aaggcaccct ttcttcagtg     3540

ggtctcagtt ctgtcctggg tactgaagaa gaagatgaag atgaggagta tgaatacatg     3600

aaccggagga gaaggcacag tccacctcat ccccctaggc caagttccct tgaggagctg     3660

ggttatgagt acatggatgt ggggtcagac ctcagtgcct ctctgggcag cacacagagt     3720

tgcccactcc accctgtacc catcatgccc actgcaggca caactccaga tgaagactat     3780

gaatatatga atcggcaacg agatggaggt ggtcctgggg gtgattatgc agccatgggg     3840

gcctgcccag catctgagca agggtatgaa gagatgagag cttttcaggg gcctggacat     3900

caggcccccc atgtccatta tgcccgccta aaaactctac gtagcttaga ggctacagac     3960

tctgcctttg ataaccctga ttactggcat agcaggcttt tccccaaggc taatgcccag     4020

agaacgtaa                                                             4029


<210>  41
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Gly Pro Gly Arg Cys Leu Leu Thr Ala Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Ala Pro Pro Pro Glu Ala Ser Gln Tyr Cys Gly Arg Leu Glu Tyr Trp 
            20                  25                  30          


Asn Pro Asp Asn Lys Cys Cys Ser Ser Cys Leu Gln Arg Phe Gly Pro 
        35                  40                  45              


Pro Pro Cys Pro Asp Tyr Glu Phe Arg Glu Asn Cys Gly Leu Asn Asp 
    50                  55                  60                  


His Gly Asp Phe Val Thr Pro Pro Phe Arg Lys Cys Ser Ser Gly Gln 
65                  70                  75                  80  


Cys Asn Pro Asp Gly Ala Glu Leu Cys Ser Pro Cys Gly Gly Gly Ala 
                85                  90                  95      


Val Thr Pro Thr Pro Ala Ala Gly Gly Gly Arg Thr Pro Trp Arg Cys 
            100                 105                 110         


Arg Glu Arg Pro Val Pro Ala Lys Gly His Cys Pro Leu Thr Pro Gly 
        115                 120                 125             


Asn Pro Gly Ala Pro Ser Ser Gln Glu Arg Ser Ser Pro Ala Ser Ser 
    130                 135                 140                 


Ile Ala Trp Arg Thr Pro Glu Pro Val Pro Gln Gln Ala Trp Pro Asn 
145                 150                 155                 160 


Phe Leu Pro Leu Val Val Leu Val Leu Leu Leu Thr Leu Ala Val Ile 
                165                 170                 175     


Ala Ile Leu Leu Phe Ile Leu Leu Trp His Leu Cys Trp Pro Lys Glu 
            180                 185                 190         


Lys Ala Asp Pro Tyr Pro Tyr Pro Gly Leu Val Cys Gly Val Pro Asn 
        195                 200                 205             


Thr His Thr Pro Ser Ser Ser His Leu Ser Ser Pro Gly Ala Leu Glu 
    210                 215                 220                 


Thr Gly Asp Thr Trp Lys Glu Ala Ser Leu Leu Pro Leu Leu Ser Arg 
225                 230                 235                 240 


Glu Leu Ser Ser Leu Ala Ser Gln Pro Leu Ser Arg Leu Leu Asp Glu 
                245                 250                 255     


Leu Glu Val Leu Glu Glu Leu Ile Val Leu Leu Asp Pro Glu Pro Gly 
            260                 265                 270         


Pro Gly Gly Gly Met Ala His Gly Thr Thr Arg His Leu Ala Ala Arg 
        275                 280                 285             


Tyr Gly Leu Pro Ala Ala Trp Ser Thr Phe Ala Tyr Ser Leu Arg Pro 
    290                 295                 300                 


Ser Arg Ser Pro Leu Arg Ala Leu Ile Glu Met Val Val Ala Arg Glu 
305                 310                 315                 320 


Pro Ser Ala Ser Leu Gly Gln Leu Gly Thr His Leu Ala Gln Leu Gly 
                325                 330                 335     


Arg Ala Asp Ala Leu Arg Val Leu Ser Lys Leu Gly Ser Ser Gly Val 
            340                 345                 350         


Cys Trp Ala 
        355 


<210>  42
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  42
atggggcctg gacgatgcct cctgacggcc ttgttgcttc tggccctggc gccaccgccg       60

gaagcctccc agtactgcgg ccgccttgaa tactggaacc cagacaacaa gtgctgcagc      120

agctgcctgc aacgcttcgg gccgcccccc tgcccggact atgagttccg ggaaaactgc      180

ggactcaatg accacggcga tttcgtaacg cccccgttcc gaaagtgttc ttctgggcag      240

tgcaaccccg acggcgcgga gctatgtagc ccctgcggcg gcggagccgt gacccctact      300

cccgccgcgg gcgggggcag aaccccgtgg cgctgcagag agaggccggt ccctgccaag      360

gggcactgcc ccctcacacc tggaaaccca ggcgccccta gctcccagga gcgcagctca      420

ccagcaagtt ccattgcctg gaggacccct gagcctgtcc ctcagcaggc ctggccgaat      480

ttccttccgc tcgtggtgct ggtcctgctc ctgaccttgg cggtgatagc gatcctcctg      540

tttattctgc tctggcatct ctgctggccc aaggagaaag ccgaccccta tccctatcct      600

ggcttggtct gcggagtccc caacacccac accccttcct cctcgcatct gtcctcccca      660

ggcgccctgg agacagggga cacatggaag gaggcctcac tacttccact cctgagcagg      720

gaactgtcca gtctggcgtc acaacccctg tctcgcctcc tggatgagct ggaggtgctg      780

gaagagctga ttgtactgct ggaccctgag cctgggccag gtgggggtat ggcccatggc      840

actactcgac acctggccgc aagatatggg ctgcctgctg cctggtccac ctttgcctat      900

tcgctgaggc cgagtcgctc gccgctgcgg gctctgattg agatggtggt ggcaagggag      960

ccctctgcct ccctgggcca gcttggcaca cacctcgccc agctagggcg ggcagatgca     1020

ttgcgggtgc tgtccaagct tggctcatct ggggtttgct gggcttaa                  1068


<210>  43
<211>  1408
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Thr Trp Trp Lys Glu Pro Leu Asn Ile Val Ser Phe Leu 
        755                 760                 765             


Phe Cys Phe Ala Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn 
    770                 775                 780                 


Leu Asn Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala 
785                 790                 795                 800 


Gly Arg Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile 
                805                 810                 815     


Ile Cys Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro 
            820                 825                 830         


Leu Lys Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr 
        835                 840                 845             


Phe Asp Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys 
    850                 855                 860                 


Pro Val Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly 
865                 870                 875                 880 


Asn Asp Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly 
                885                 890                 895     


Asn Lys Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys 
            900                 905                 910         


Thr Val Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu 
        915                 920                 925             


Trp Lys Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln 
    930                 935                 940                 


Pro Asp Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser 
945                 950                 955                 960 


Thr Ala Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg 
                965                 970                 975     


Lys Gln Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg 
            980                 985                 990         


Val His Thr Pro His Leu Asp Arg  Leu Val Ser Ala Arg  Ser Val Ser 
        995                 1000                 1005             


Pro Thr  Thr Glu Met Val Ser  Asn Glu Ser Val Asp  Tyr Arg Ala 
    1010                 1015                 1020             


Thr Phe  Pro Glu Asp Gln Phe  Pro Asn Ser Ser Gln  Asn Gly Ser 
    1025                 1030                 1035             


Cys Arg  Gln Val Gln Tyr Pro  Leu Thr Asp Met Ser  Pro Ile Leu 
    1040                 1045                 1050             


Thr Ser  Gly Asp Ser Asp Ile  Ser Ser Pro Leu Leu  Gln Asn Thr 
    1055                 1060                 1065             


Val His  Ile Asp Leu Ser Ala  Leu Asn Pro Glu Leu  Val Gln Ala 
    1070                 1075                 1080             


Val Gln  His Val Val Ile Gly  Pro Ser Ser Leu Ile  Val His Phe 
    1085                 1090                 1095             


Asn Glu  Val Ile Gly Arg Gly  His Phe Gly Cys Val  Tyr His Gly 
    1100                 1105                 1110             


Thr Leu  Leu Asp Asn Asp Gly  Lys Lys Ile His Cys  Ala Val Lys 
    1115                 1120                 1125             


Ser Leu  Asn Arg Ile Thr Asp  Ile Gly Glu Val Ser  Gln Phe Leu 
    1130                 1135                 1140             


Thr Glu  Gly Ile Ile Met Lys  Asp Phe Ser His Pro  Asn Val Leu 
    1145                 1150                 1155             


Ser Leu  Leu Gly Ile Cys Leu  Arg Ser Glu Gly Ser  Pro Leu Val 
    1160                 1165                 1170             


Val Leu  Pro Tyr Met Lys His  Gly Asp Leu Arg Asn  Phe Ile Arg 
    1175                 1180                 1185             


Asn Glu  Thr His Asn Pro Thr  Val Lys Asp Leu Ile  Gly Phe Gly 
    1190                 1195                 1200             


Leu Gln  Val Ala Lys Gly Met  Lys Tyr Leu Ala Ser  Lys Lys Phe 
    1205                 1210                 1215             


Val His  Arg Asp Leu Ala Ala  Arg Asn Cys Met Leu  Asp Glu Lys 
    1220                 1225                 1230             


Phe Thr  Val Lys Val Ala Asp  Phe Gly Leu Ala Arg  Asp Met Tyr 
    1235                 1240                 1245             


Asp Lys  Glu Tyr Tyr Ser Val  His Asn Lys Thr Gly  Ala Lys Leu 
    1250                 1255                 1260             


Pro Val  Lys Trp Met Ala Leu  Glu Ser Leu Gln Thr  Gln Lys Phe 
    1265                 1270                 1275             


Thr Thr  Lys Ser Asp Val Trp  Ser Phe Gly Val Leu  Leu Trp Glu 
    1280                 1285                 1290             


Leu Met  Thr Arg Gly Ala Pro  Pro Tyr Pro Asp Val  Asn Thr Phe 
    1295                 1300                 1305             


Asp Ile  Thr Val Tyr Leu Leu  Gln Gly Arg Arg Leu  Leu Gln Pro 
    1310                 1315                 1320             


Glu Tyr  Cys Pro Asp Pro Leu  Tyr Glu Val Met Leu  Lys Cys Trp 
    1325                 1330                 1335             


His Pro  Lys Ala Glu Met Arg  Pro Ser Phe Ser Glu  Leu Val Ser 
    1340                 1345                 1350             


Arg Ile  Ser Ala Ile Phe Ser  Thr Phe Ile Gly Glu  His Tyr Val 
    1355                 1360                 1365             


His Val  Asn Ala Thr Tyr Val  Asn Val Lys Cys Val  Ala Pro Tyr 
    1370                 1375                 1380             


Pro Ser  Leu Leu Ser Ser Glu  Asp Asn Ala Asp Asp  Glu Val Asp 
    1385                 1390                 1395             


Thr Arg  Pro Ala Ser Phe Trp  Glu Thr Ser 
    1400                 1405             


<210>  44
<211>  4227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  44
atgaaggccc ccgctgtgct tgcacctggc atcctcgtgc tcctgtttac cttggtgcag       60

aggagcaatg gggagtgtaa agaggcacta gcaaagtccg agatgaatgt gaatatgaag      120

tatcagcttc ccaacttcac cgcggaaaca cccatccaga atgtcattct acatgagcat      180

cacattttcc ttggtgccac taactacatt tatgttttaa atgaggaaga ccttcagaag      240

gttgctgagt acaagactgg gcctgtgctg gaacacccag attgtttccc atgtcaggac      300

tgcagcagca aagccaattt atcaggaggt gtttggaaag ataacatcaa catggctcta      360

gttgtcgaca cctactatga tgatcaactc attagctgtg gcagcgtcaa cagagggacc      420

tgccagcgac atgtctttcc ccacaatcat actgctgaca tacagtcgga ggttcactgc      480

atattctccc cacagataga agagcccagc cagtgtcctg actgtgtggt gagcgccctg      540

ggagccaaag tcctttcatc tgtaaaggac cggttcatca acttctttgt aggcaatacc      600

ataaattctt cttatttccc agatcatcca ttgcattcga tatcagtgag aaggctaaag      660

gaaacgaaag atggttttat gtttttgacg gaccagtcct acattgatgt tttacctgag      720

ttcagagatt cttaccccat taagtatgtc catgcctttg aaagcaacaa ttttatttac      780

ttcttgacgg tccaaaggga aactctagat gctcagactt ttcacacaag aataatcagg      840

ttctgttcca taaactctgg attgcattcc tacatggaaa tgcctctgga gtgtattctc      900

acagaaaaga gaaaaaagag atccacaaag aaggaagtgt ttaatatact tcaggctgcg      960

tatgtcagca agcctggggc ccagcttgct agacaaatag gagccagcct gaatgatgac     1020

attcttttcg gggtgttcgc acaaagcaag ccagattctg ccgaaccaat ggatcgatct     1080

gccatgtgtg cattccctat caaatatgtc aacgacttct tcaacaagat cgtcaacaaa     1140

aacaatgtga gatgtctcca gcatttttac ggacccaatc atgagcactg ctttaatagg     1200

acacttctga gaaattcatc aggctgtgaa gcgcgccgtg atgaatatcg aacagagttt     1260

accacagctt tgcagcgcgt tgacttattc atgggtcaat tcagcgaagt cctcttaaca     1320

tctatatcca ccttcattaa aggagacctc accatagcta atcttgggac atcagagggt     1380

cgcttcatgc aggttgtggt ttctcgatca ggaccatcaa cccctcatgt gaattttctc     1440

ctggactccc atccagtgtc tccagaagtg attgtggagc atacattaaa ccaaaatggc     1500

tacacactgg ttatcactgg gaagaagatc acgaagatcc cattgaatgg cttgggctgc     1560

agacatttcc agtcctgcag tcaatgcctc tctgccccac cctttgttca gtgtggctgg     1620

tgccacgaca aatgtgtgcg atcggaggaa tgcctgagcg ggacatggac tcaacagatc     1680

tgtctgcctg caatctacaa ggttttccca aatagtgcac cccttgaagg agggacaagg     1740

ctgaccatat gtggctggga ctttggattt cggaggaata ataaatttga tttaaagaaa     1800

actagagttc tccttggaaa tgagagctgc accttgactt taagtgagag cacgatgaat     1860

acattgaaat gcacagttgg tcctgccatg aataagcatt tcaatatgtc cataattatt     1920

tcaaatggcc acgggacaac acaatacagt acattctcct atgtggatcc tgtaataaca     1980

agtatttcgc cgaaatacgg tcctatggct ggtggcactt tacttacttt aactggaaat     2040

tacctaaaca gtgggaattc tagacacatt tcaattggtg gaaaaacatg tactttaaaa     2100

agtgtgtcaa acagtattct tgaatgttat accccagccc aaaccatttc aactgagttt     2160

gctgttaaat tgaaaattga cttagccaac cgagagacaa gcatcttcag ttaccgtgaa     2220

gatcccattg tctatgaaat tcatccaacc aaatctttta ttagtacttg gtggaaagaa     2280

cctctcaaca ttgtcagttt tctattttgc tttgccagtg gtgggagcac aataacaggt     2340

gttgggaaaa acctgaattc agttagtgtc ccgagaatgg tcataaatgt gcatgaagca     2400

ggaaggaact ttacagtggc atgtcaacat cgctctaatt cagagataat ctgttgtacc     2460

actccttccc tgcaacagct gaatctgcaa ctccccctga aaaccaaagc ctttttcatg     2520

ttagatggga tcctttccaa atactttgat ctcatttatg tacataatcc tgtgtttaag     2580

ccttttgaaa agccagtgat gatctcaatg ggcaatgaaa atgtactgga aattaaggga     2640

aatgatattg accctgaagc agttaaaggt gaagtgttaa aagttggaaa taagagctgt     2700

gagaatatac acttacattc tgaagccgtt ttatgcacgg tccccaatga cctgctgaaa     2760

ttgaacagcg agctaaatat agagtggaag caagcaattt cttcaaccgt ccttggaaaa     2820

gtaatagttc aaccagatca gaatttcaca ggattgattg ctggtgttgt ctcaatatca     2880

acagcactgt tattactact tgggtttttc ctgtggctga aaaagagaaa gcaaattaaa     2940

gatctgggca gtgaattagt tcgctacgat gcaagagtac acactcctca tttggatagg     3000

cttgtaagtg cccgaagtgt aagcccaact acagaaatgg tttcaaatga atctgtagac     3060

taccgagcta cttttccaga agatcagttt cctaattcat ctcagaacgg ttcatgccga     3120

caagtgcagt atcctctgac agacatgtcc cccatcctaa ctagtgggga ctctgatata     3180

tccagtccat tactgcaaaa tactgtccac attgacctca gtgctctaaa tccagagctg     3240

gtccaggcag tgcagcatgt agtgattggg cccagtagcc tgattgtgca tttcaatgaa     3300

gtcataggaa gagggcattt tggttgtgta tatcatggga ctttgttgga caatgatggc     3360

aagaaaattc actgtgctgt gaaatccttg aacagaatca ctgacatagg agaagtttcc     3420

caatttctga ccgagggaat catcatgaaa gattttagtc atcccaatgt cctctcgctc     3480

ctgggaatct gcctgcgaag tgaagggtct ccgctggtgg tcctaccata catgaaacat     3540

ggagatcttc gaaatttcat tcgaaatgag actcataatc caactgtaaa agatcttatt     3600

ggctttggtc ttcaagtagc caaaggcatg aaatatcttg caagcaaaaa gtttgtccac     3660

agagacttgg ctgcaagaaa ctgtatgctg gatgaaaaat tcacagtcaa ggttgctgat     3720

tttggtcttg ccagagacat gtatgataaa gaatactata gtgtacacaa caaaacaggt     3780

gcaaagctgc cagtgaagtg gatggctttg gaaagtctgc aaactcaaaa gtttaccacc     3840

aagtcagatg tgtggtcctt tggcgtgctc ctctgggagc tgatgacaag aggagcccca     3900

ccttatcctg acgtaaacac ctttgatata actgtttact tgttgcaagg gagaagactc     3960

ctacaacccg aatactgccc agacccctta tatgaagtaa tgctaaaatg ctggcaccct     4020

aaagccgaaa tgcgcccatc cttttctgaa ctggtgtccc ggatatcagc gatcttctct     4080

actttcattg gggagcacta tgtccatgtg aacgctactt atgtgaacgt aaaatgtgtc     4140

gctccgtatc cttctctgtt gtcatcagaa gataacgctg atgatgaggt ggacacacga     4200

ccagcctcct tctgggagac atcatag                                         4227


<210>  45
<211>  1356
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  46
<211>  4071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  46
atgcagagca aggtgctgct ggccgtcgcc ctgtggctct gcgtggagac ccgggccgcc       60

tctgtgggtt tgcctagtgt ttctcttgat ctgcccaggc tcagcataca aaaagacata      120

cttacaatta aggctaatac aactcttcaa attacttgca ggggacagag ggacttggac      180

tggctttggc ccaataatca gagtggcagt gagcaaaggg tggaggtgac tgagtgcagc      240

gatggcctct tctgtaagac actcacaatt ccaaaagtga tcggaaatga cactggagcc      300

tacaagtgct tctaccggga aactgacttg gcctcggtca tttatgtcta tgttcaagat      360

tacagatctc catttattgc ttctgttagt gaccaacatg gagtcgtgta cattactgag      420

aacaaaaaca aaactgtggt gattccatgt ctcgggtcca tttcaaatct caacgtgtca      480

ctttgtgcaa gatacccaga aaagagattt gttcctgatg gtaacagaat ttcctgggac      540

agcaagaagg gctttactat tcccagctac atgatcagct atgctggcat ggtcttctgt      600

gaagcaaaaa ttaatgatga aagttaccag tctattatgt acatagttgt cgttgtaggg      660

tataggattt atgatgtggt tctgagtccg tctcatggaa ttgaactatc tgttggagaa      720

aagcttgtct taaattgtac agcaagaact gaactaaatg tggggattga cttcaactgg      780

gaataccctt cttcgaagca tcagcataag aaacttgtaa accgagacct aaaaacccag      840

tctgggagtg agatgaagaa atttttgagc accttaacta tagatggtgt aacccggagt      900

gaccaaggat tgtacacctg tgcagcatcc agtgggctga tgaccaagaa gaacagcaca      960

tttgtcaggg tccatgaaaa accttttgtt gcttttggaa gtggcatgga atctctggtg     1020

gaagccacgg tgggggagcg tgtcagaatc cctgcgaagt accttggtta cccaccccca     1080

gaaataaaat ggtataaaaa tggaataccc cttgagtcca atcacacaat taaagcgggg     1140

catgtactga cgattatgga agtgagtgaa agagacacag gaaattacac tgtcatcctt     1200

accaatccca tttcaaagga gaagcagagc catgtggtct ctctggttgt gtatgtccca     1260

ccccagattg gtgagaaatc tctaatctct cctgtggatt cctaccagta cggcaccact     1320

caaacgctga catgtacggt ctatgccatt cctcccccgc atcacatcca ctggtattgg     1380

cagttggagg aagagtgcgc caacgagccc agccaagctg tctcagtgac aaacccatac     1440

ccttgtgaag aatggagaag tgtggaggac ttccagggag gaaataaaat tgaagttaat     1500

aaaaatcaat ttgctctaat tgaaggaaaa aacaaaactg taagtaccct tgttatccaa     1560

gcggcaaatg tgtcagcttt gtacaaatgt gaagcggtca acaaagtcgg gagaggagag     1620

agggtgatct ccttccacgt gaccaggggt cctgaaatta ctttgcaacc tgacatgcag     1680

cccactgagc aggagagcgt gtctttgtgg tgcactgcag acagatctac gtttgagaac     1740

ctcacatggt acaagcttgg cccacagcct ctgccaatcc atgtgggaga gttgcccaca     1800

cctgtttgca agaacttgga tactctttgg aaattgaatg ccaccatgtt ctctaatagc     1860

acaaatgaca ttttgatcat ggagcttaag aatgcatcct tgcaggacca aggagactat     1920

gtctgccttg ctcaagacag gaagaccaag aaaagacatt gcgtggtcag gcagctcaca     1980

gtcctagagc gtgtggcacc cacgatcaca ggaaacctgg agaatcagac gacaagtatt     2040

ggggaaagca tcgaagtctc atgcacggca tctgggaatc cccctccaca gatcatgtgg     2100

tttaaagata atgagaccct tgtagaagac tcaggcattg tattgaagga tgggaaccgg     2160

aacctcacta tccgcagagt gaggaaggag gacgaaggcc tctacacctg ccaggcatgc     2220

agtgttcttg gctgtgcaaa agtggaggca tttttcataa tagaaggtgc ccaggaaaag     2280

acgaacttgg aaatcattat tctagtaggc acggcggtga ttgccatgtt cttctggcta     2340

cttcttgtca tcatcctacg gaccgttaag cgggccaatg gaggggaact gaagacaggc     2400

tacttgtcca tcgtcatgga tccagatgaa ctcccattgg atgaacattg tgaacgactg     2460

ccttatgatg ccagcaaatg ggaattcccc agagaccggc tgaagctagg taagcctctt     2520

ggccgtggtg cctttggcca agtgattgaa gcagatgcct ttggaattga caagacagca     2580

acttgcagga cagtagcagt caaaatgttg aaagaaggag caacacacag tgagcatcga     2640

gctctcatgt ctgaactcaa gatcctcatt catattggtc accatctcaa tgtggtcaac     2700

cttctaggtg cctgtaccaa gccaggaggg ccactcatgg tgattgtgga attctgcaaa     2760

tttggaaacc tgtccactta cctgaggagc aagagaaatg aatttgtccc ctacaagacc     2820

aaaggggcac gattccgtca agggaaagac tacgttggag caatccctgt ggatctgaaa     2880

cggcgcttgg acagcatcac cagtagccag agctcagcca gctctggatt tgtggaggag     2940

aagtccctca gtgatgtaga agaagaggaa gctcctgaag atctgtataa ggacttcctg     3000

accttggagc atctcatctg ttacagcttc caagtggcta agggcatgga gttcttggca     3060

tcgcgaaagt gtatccacag ggacctggcg gcacgaaata tcctcttatc ggagaagaac     3120

gtggttaaaa tctgtgactt tggcttggcc cgggatattt ataaagatcc agattatgtc     3180

agaaaaggag atgctcgcct ccctttgaaa tggatggccc cagaaacaat ttttgacaga     3240

gtgtacacaa tccagagtga cgtctggtct tttggtgttt tgctgtggga aatattttcc     3300

ttaggtgctt ctccatatcc tggggtaaag attgatgaag aattttgtag gcgattgaaa     3360

gaaggaacta gaatgagggc ccctgattat actacaccag aaatgtacca gaccatgctg     3420

gactgctggc acggggagcc cagtcagaga cccacgtttt cagagttggt ggaacatttg     3480

ggaaatctct tgcaagctaa tgctcagcag gatggcaaag actacattgt tcttccgata     3540

tcagagactt tgagcatgga agaggattct ggactctctc tgcctacctc acctgtttcc     3600

tgtatggagg aggaggaagt atgtgacccc aaattccatt atgacaacac agcaggaatc     3660

agtcagtatc tgcagaacag taagcgaaag agccggcctg tgagtgtaaa aacatttgaa     3720

gatatcccgt tagaagaacc agaagtaaaa gtaatcccag atgacaacca gacggacagt     3780

ggtatggttc ttgcctcaga agagctgaaa actttggaag acagaaccaa attatctcca     3840

tcttttggtg gaatggtgcc cagcaaaagc agggagtctg tggcatctga aggctcaaac     3900

cagacaagcg gctaccagtc cggatatcac tccgatgaca cagacaccac cgtgtactcc     3960

agtgaggaag cagaactttt aaagctgata gagattggag tgcaaaccgg tagcacagcc     4020

cagattctcc agcctgactc ggggaccaca ctgagctctc ctcctgttta a              4071


<210>  47
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  48
<211>  2919
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  48
atgagaggcg ctcgcggcgc ctgggatttt ctctgcgttc tgctcctact gcttcgcgtc       60

cagacaggct cttctcaacc atctgtgagt ccaggggaac cgtctccacc atccatccat      120

ccaggaaaat cagacttaat agtccgcgtg ggcgacgaga ttaggctgtt atgcactgat      180

ccgggctttg tcaaatggac ttttgagatc ctggatgaaa cgaatgagaa taagcagaat      240

gaatggatca cggaaaaggc agaagccacc aacaccggca aatacacgtg caccaacaaa      300

cacggcttaa gcaattccat ttatgtgttt gttagagatc ctgccaagct tttccttgtt      360

gaccgctcct tgtatgggaa agaagacaac gacacgctgg tccgctgtcc tctcacagac      420

ccagaagtga ccaattattc cctcaagggg tgccagggga agcctcttcc caaggacttg      480

aggtttattc ctgaccccaa ggcgggcatc atgatcaaaa gtgtgaaacg cgcctaccat      540

cggctctgtc tgcattgttc tgtggaccag gagggcaagt cagtgctgtc ggaaaaattc      600

atcctgaaag tgaggccagc cttcaaagct gtgcctgttg tgtctgtgtc caaagcaagc      660

tatcttctta gggaagggga agaattcaca gtgacgtgca caataaaaga tgtgtctagt      720

tctgtgtact caacgtggaa aagagaaaac agtcagacta aactacagga gaaatataat      780

agctggcatc acggtgactt caattatgaa cgtcaggcaa cgttgactat cagttcagcg      840

agagttaatg attctggagt gttcatgtgt tatgccaata atacttttgg atcagcaaat      900

gtcacaacaa ccttggaagt agtagataaa ggattcatta atatcttccc catgataaac      960

actacagtat ttgtaaacga tggagaaaat gtagatttga ttgttgaata tgaagcattc     1020

cccaaacctg aacaccagca gtggatctat atgaacagaa ccttcactga taaatgggaa     1080

gattatccca agtctgagaa tgaaagtaat atcagatacg taagtgaact tcatctaacg     1140

agattaaaag gcaccgaagg aggcacttac acattcctag tgtccaattc tgacgtcaat     1200

gctgccatag catttaatgt ttatgtgaat acaaaaccag aaatcctgac ttacgacagg     1260

ctcgtgaatg gcatgctcca atgtgtggca gcaggattcc cagagcccac aatagattgg     1320

tatttttgtc caggaactga gcagagatgc tctgcttctg tactgccagt ggatgtgcag     1380

acactaaact catctgggcc accgtttgga aagctagtgg ttcagagttc tatagattct     1440

agtgcattca agcacaatgg cacggttgaa tgtaaggctt acaacgatgt gggcaagact     1500

tctgcctatt ttaactttgc atttaaagag caaatccatc cccacaccct gttcactcct     1560

ttgctgattg gtttcgtaat cgtagctggc atgatgtgca ttattgtgat gattctgacc     1620

tacaaatatt tacagaaacc catgtatgaa gtacagtgga aggttgttga ggagataaat     1680

ggaaacaatt atgtttacat agacccaaca caacttcctt atgatcacaa atgggagttt     1740

cccagaaaca ggctgagttt tgggaaaacc ctgggtgctg gagctttcgg gaaggttgtt     1800

gaggcaactg cttatggctt aattaagtca gatgcggcca tgactgtcgc tgtaaagatg     1860

ctcaagccga gtgcccattt gacagaacgg gaagccctca tgtctgaact caaagtcctg     1920

agttaccttg gtaatcacat gaatattgtg aatctacttg gagcctgcac cattggaggg     1980

cccaccctgg tcattacaga atattgttgc tatggtgatc ttttgaattt tttgagaaga     2040

aaacgtgatt catttatttg ttcaaagcag gaagatcatg cagaagctgc actttataag     2100

aatcttctgc attcaaagga gtcttcctgc agcgatagta ctaatgagta catggacatg     2160

aaacctggag tttcttatgt tgtcccaacc aaggccgaca aaaggagatc tgtgagaata     2220

ggctcataca tagaaagaga tgtgactccc gccatcatgg aggatgacga gttggcccta     2280

gacttagaag acttgctgag cttttcttac caggtggcaa agggcatggc tttcctcgcc     2340

tccaagaatt gtattcacag agacttggca gccagaaata tcctccttac tcatggtcgg     2400

atcacaaaga tttgtgattt tggtctagcc agagacatca agaatgattc taattatgtg     2460

gttaaaggaa acgctcgact acctgtgaag tggatggcac ctgaaagcat tttcaactgt     2520

gtatacacgt ttgaaagtga cgtctggtcc tatgggattt ttctttggga gctgttctct     2580

ttaggaagca gcccctatcc tggaatgccg gtcgattcta agttctacaa gatgatcaag     2640

gaaggcttcc ggatgctcag ccctgaacac gcacctgctg aaatgtatga cataatgaag     2700

acttgctggg atgcagatcc cctaaaaaga ccaacattca agcaaattgt tcagctaatt     2760

gagaagcaga tttcagagag caccaatcat atttactcca acttagcaaa ctgcagcccc     2820

aaccgacaga agcccgtggt agaccattct gtgcggatca attctgtcgg cagcaccgct     2880

tcctcctccc agcctctgct tgtgcacgac gatgtctga                            2919


<210>  49
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 
                805                 810                 815     


Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 
            820                 825                 830         


Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 
        835                 840                 845             


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 
    850                 855                 860                 


Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
865                 870                 875                 880 


Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 
                885                 890                 895     


Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 
            900                 905                 910         


Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 
        915                 920                 925             


Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 
    930                 935                 940                 


Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 
945                 950                 955                 960 


Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 
                965                 970                 975     


Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 
            980                 985                 990         


Ser 
    


<210>  50
<211>  2982
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  50
atgccggcgt tggcgcgcga cggcggccag ctgccgctgc tcgttgtttt ttctgcaatg       60

atatttggga ctattacaaa tcaagatctg cctgtgatca agtgtgtttt aatcaatcat      120

aagaacaatg attcatcagt ggggaagtca tcatcatatc ccatggtatc agaatccccg      180

gaagacctcg ggtgtgcgtt gagaccccag agctcaggga cagtgtacga agctgccgct      240

gtggaagtgg atgtatctgc ttccatcaca ctgcaagtgc tggtcgacgc cccagggaac      300

atttcctgtc tctgggtctt taagcacagc tccctgaatt gccagccaca ttttgattta      360

caaaacagag gagttgtttc catggtcatt ttgaaaatga cagaaaccca agctggagaa      420

tacctacttt ttattcagag tgaagctacc aattacacaa tattgtttac agtgagtata      480

agaaataccc tgctttacac attaagaaga ccttacttta gaaaaatgga aaaccaggac      540

gccctggtct gcatatctga gagcgttcca gagccgatcg tggaatgggt gctttgcgat      600

tcacaggggg aaagctgtaa agaagaaagt ccagctgttg ttaaaaagga ggaaaaagtg      660

cttcatgaat tatttgggac ggacataagg tgctgtgcca gaaatgaact gggcagggaa      720

tgcaccaggc tgttcacaat agatctaaat caaactcctc agaccacatt gccacaatta      780

tttcttaaag taggggaacc cttatggata aggtgcaaag ctgttcatgt gaaccatgga      840

ttcgggctca cctgggaatt agaaaacaaa gcactcgagg agggcaacta ctttgagatg      900

agtacctatt caacaaacag aactatgata cggattctgt ttgcttttgt atcatcagtg      960

gcaagaaacg acaccggata ctacacttgt tcctcttcaa agcatcccag tcaatcagct     1020

ttggttacca tcgtagaaaa gggatttata aatgctacca attcaagtga agattatgaa     1080

attgaccaat atgaagagtt ttgtttttct gtcaggttta aagcctaccc acaaatcaga     1140

tgtacgtgga ccttctctcg aaaatcattt ccttgtgagc aaaagggtct tgataacgga     1200

tacagcatat ccaagttttg caatcataag caccagccag gagaatatat attccatgca     1260

gaaaatgatg atgcccaatt taccaaaatg ttcacgctga atataagaag gaaacctcaa     1320

gtgctcgcag aagcatcggc aagtcaggcg tcctgtttct cggatggata cccattacca     1380

tcttggacct ggaagaagtg ttcagacaag tctcccaact gcacagaaga gatcacagaa     1440

ggagtctgga atagaaaggc taacagaaaa gtgtttggac agtgggtgtc gagcagtact     1500

ctaaacatga gtgaagccat aaaagggttc ctggtcaagt gctgtgcata caattccctt     1560

ggcacatctt gtgagacgat ccttttaaac tctccaggcc ccttcccttt catccaagac     1620

aacatctcat tctatgcaac aattggtgtt tgtctcctct tcattgtcgt tttaaccctg     1680

ctaatttgtc acaagtacaa aaagcaattt aggtatgaaa gccagctaca gatggtacag     1740

gtgaccggct cctcagataa tgagtacttc tacgttgatt tcagagaata tgaatatgat     1800

ctcaaatggg agtttccaag agaaaattta gagtttggga aggtactagg atcaggtgct     1860

tttggaaaag tgatgaacgc aacagcttat ggaattagca aaacaggagt ctcaatccag     1920

gttgccgtca aaatgctgaa agaaaaagca gacagctctg aaagagaggc actcatgtca     1980

gaactcaaga tgatgaccca gctgggaagc cacgagaata ttgtgaacct gctgggggcg     2040

tgcacactgt caggaccaat ttacttgatt tttgaatact gttgctatgg tgatcttctc     2100

aactatctaa gaagtaaaag agaaaaattt cacaggactt ggacagagat tttcaaggaa     2160

cacaatttca gtttttaccc cactttccaa tcacatccaa attccagcat gcctggttca     2220

agagaagttc agatacaccc ggactcggat caaatctcag ggcttcatgg gaattcattt     2280

cactctgaag atgaaattga atatgaaaac caaaaaaggc tggaagaaga ggaggacttg     2340

aatgtgctta catttgaaga tcttctttgc tttgcatatc aagttgccaa aggaatggaa     2400

tttctggaat ttaagtcgtg tgttcacaga gacctggccg ccaggaacgt gcttgtcacc     2460

cacgggaaag tggtgaagat atgtgacttt ggattggctc gagatatcat gagtgattcc     2520

aactatgttg tcaggggcaa tgcccgtctg cctgtaaaat ggatggcccc cgaaagcctg     2580

tttgaaggca tctacaccat taagagtgat gtctggtcat atggaatatt actgtgggaa     2640

atcttctcac ttggtgtgaa tccttaccct ggcattccgg ttgatgctaa cttctacaaa     2700

ctgattcaaa atggatttaa aatggatcag ccattttatg ctacagaaga aatatacatt     2760

ataatgcaat cctgctgggc ttttgactca aggaaacggc catccttccc taatttgact     2820

tcgtttttag gatgtcagct ggcagatgca gaagaagcga tgtatcagaa tgtggatggc     2880

cgtgtttcgg aatgtcctca cacctaccaa aacaggcgac ctttcagcag agagatggat     2940

ttggggctac tctctccgca ggctcaggtc gaagattcgt ag                        2982


<210>  51
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Pro Leu Leu Phe Leu Glu Arg Phe Pro Trp Pro Ser Leu Arg Thr 
1               5                   10                  15      


Tyr Thr Gly Leu Ser Gly Leu Ala Leu Leu Gly Thr Ile Ile Ser Ala 
            20                  25                  30          


Tyr Arg Ala Leu Ser Gln Pro Glu Ala Gly Pro Gly Glu Pro Asp Gln 
        35                  40                  45              


Leu Thr Ala Ser Leu Gln Pro Glu Pro Pro Ala Pro Ala Arg Pro Ser 
    50                  55                  60                  


Ala Gly Gly Pro Arg Ala Arg Asp Val Ala Gln Tyr Leu Leu Ser Asp 
65                  70                  75                  80  


Ser Leu Phe Val Trp Val Leu Val Asn Thr Ala Cys Cys Val Leu Met 
                85                  90                  95      


Leu Val Ala Lys Leu Ile Gln Cys Ile Val Phe Gly Pro Leu Arg Val 
            100                 105                 110         


Ser Glu Arg Gln His Leu Lys Asp Lys Phe Trp Asn Phe Ile Phe Tyr 
        115                 120                 125             


Lys Phe Ile Phe Ile Phe Gly Val Leu Asn Val Gln Thr Val Glu Glu 
    130                 135                 140                 


Val Val Met Trp Cys Leu Trp Phe Ala Gly Leu Val Phe Leu His Leu 
145                 150                 155                 160 


Met Val Gln Leu Cys Lys Asp Arg Phe Glu Tyr Leu Ser Phe Ser Pro 
                165                 170                 175     


Thr Thr Pro Met Ser Ser His Gly Arg Val Leu Ser Leu Leu Val Ala 
            180                 185                 190         


Met Leu Leu Ser Cys Cys Gly Leu Ala Ala Val Cys Ser Ile Thr Gly 
        195                 200                 205             


Tyr Thr His Gly Met His Thr Leu Ala Phe Met Ala Ala Glu Ser Leu 
    210                 215                 220                 


Leu Val Thr Val Arg Thr Ala His Val Ile Leu Arg Tyr Val Ile His 
225                 230                 235                 240 


Leu Trp Asp Leu Asn His Glu Gly Thr Trp Glu Gly Lys Gly Thr Tyr 
                245                 250                 255     


Val Tyr Tyr Thr Asp Phe Val Met Glu Leu Thr Leu Leu Ser Leu Asp 
            260                 265                 270         


Leu Met His His Ile His Met Leu Leu Phe Gly Asn Ile Trp Leu Ser 
        275                 280                 285             


Met Ala Ser Leu Val Ile Phe Met Gln Leu Arg Tyr Leu Phe His Glu 
    290                 295                 300                 


Val Gln Arg Arg Ile Arg Arg His Lys Asn Tyr Leu Arg Val Val Gly 
305                 310                 315                 320 


Asn Met Glu Ala Arg Phe Ala Val Ala Thr Pro Glu Glu Leu Ala Val 
                325                 330                 335     


Asn Asn Asp Asp Cys Ala Ile Cys Trp Asp Ser Met Gln Ala Ala Arg 
            340                 345                 350         


Lys Leu Pro Cys Gly His Leu Phe His Asn Ser Cys Leu Arg Ser Trp 
        355                 360                 365             


Leu Glu Gln Asp Thr Ser Cys Pro Thr Cys Arg Met Ser Leu Asn Ile 
    370                 375                 380                 


Ala Asp Asn Asn Arg Val Arg Glu Glu His Gln Gly Glu Asn Leu Asp 
385                 390                 395                 400 


Glu Asn Leu Val Pro Val Ala Ala Ala Glu Gly Arg Pro Arg Leu Asn 
                405                 410                 415     


Gln His Asn His Phe Phe His Phe Asp Gly Ser Arg Ile Ala Ser Trp 
            420                 425                 430         


Leu Pro Ser Phe Ser Val Glu Val Met His Thr Thr Asn Ile Leu Gly 
        435                 440                 445             


Ile Thr Gln Ala Ser Asn Ser Gln Leu Asn Ala Met Ala His Gln Ile 
    450                 455                 460                 


Gln Glu Met Phe Pro Gln Val Pro Tyr His Leu Val Leu Gln Asp Leu 
465                 470                 475                 480 


Gln Leu Thr Arg Ser Val Glu Ile Thr Thr Asp Asn Ile Leu Glu Gly 
                485                 490                 495     


Arg Ile Gln Val Pro Phe Pro Thr Gln Arg Ser Asp Ser Ile Arg Pro 
            500                 505                 510         


Ala Leu Asn Ser Pro Val Glu Arg Pro Ser Ser Asp Gln Glu Glu Gly 
        515                 520                 525             


Glu Thr Ser Ala Gln Thr Glu Arg Val Pro Leu Asp Leu Ser Pro Arg 
    530                 535                 540                 


Leu Glu Glu Thr Leu Asp Phe Gly Glu Val Glu Val Glu Pro Ser Glu 
545                 550                 555                 560 


Val Glu Asp Phe Glu Ala Arg Gly Ser Arg Phe Ser Lys Ser Ala Asp 
                565                 570                 575     


Glu Arg Gln Arg Met Leu Val Gln Arg Lys Asp Glu Leu Leu Gln Gln 
            580                 585                 590         


Ala Arg Lys Arg Phe Leu Asn Lys Ser Ser Glu Asp Asp Ala Ala Ser 
        595                 600                 605             


Glu Ser Phe Leu Pro Leu Glu Gly Ala Ser Ser Asp Pro Val Thr Leu 
    610                 615                 620                 


Arg Arg Arg Met Leu Ala Ala Ala Ala Glu Arg Arg Leu Gln Lys Gln 
625                 630                 635                 640 


Gln Thr Ser 
            


<210>  52
<211>  1932
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  52
atgccgctgc tcttcctcga gcgcttcccc tggcccagcc tccgcaccta cacgggcctc       60

agcggcctgg ccctgctggg caccatcatc agcgcctacc gcgcgctcag ccagcccgag      120

gccggccccg gcgagccgga ccagctaacg gcctcgctgc agcctgagcc gccggcgccc      180

gcccggccga gcgccggggg accccgggcc cgcgatgtgg cccagtacct gctctcagac      240

agcctcttcg tgtgggttct agtaaatacc gcttgctgtg ttttgatgtt ggtggctaag      300

ctcatccagt gtattgtgtt tggccctctt cgagtgagtg agagacagca tctcaaagac      360

aaattttgga attttatttt ctacaagttc attttcatct ttggtgtgct gaatgtccag      420

acagtggaag aggtggtcat gtggtgcctc tggtttgccg gacttgtctt tctgcacctg      480

atggttcagc tctgcaagga tcgatttgaa tatctttcct tctcgcccac cacgccgatg      540

agcagccacg gtcgagtcct gtccctgttg gttgccatgc tgctttcctg ctgtggactg      600

gcggccgtct gctccatcac cggctacacc cacggaatgc acaccttggc tttcatggct      660

gcagagtctc ttcttgtgac agtgaggact gctcatgtga ttttacgata cgtaattcac      720

ctctgggacc tcaaccacga agggacgtgg gaaggaaagg ggacgtatgt ctattacaca      780

gactttgtca tggagctcac tctcctgtcc ctggacctca tgcaccatat tcacatgttg      840

ttatttggca acatctggtt atccatggcc agcctggtca tctttatgca gctgcgttac      900

ctgtttcatg aggtgcaacg tcgaattcgt cggcacaaga actatctacg tgtggttgga      960

aacatggagg ccaggtttgc agttgcaact ccagaggagc tggctgtcaa caatgacgac     1020

tgtgccatct gttgggactc catgcaggct gcgcggaaac tgccctgtgg acatcttttc     1080

cacaactcct gtcttcgttc ctggctagaa caagacacct cctgtccaac atgcagaatg     1140

tctcttaata ttgccgacaa taatcgtgtc agggaagaac atcaaggaga gaacttggat     1200

gagaatttgg ttcctgtagc agcagccgaa gggagacctc gcttaaacca acacaatcac     1260

ttcttccatt tcgatgggtc tcggattgcg agctggctgc cgagtttttc ggttgaagtg     1320

atgcacacca ccaacattct tggcattacg caggccagca actcccagct caatgcaatg     1380

gctcatcaga ttcaagagat gtttccccag gttccatacc atctggtact gcaggacctc     1440

cagctgacac gctcagttga aataacaaca gacaatattt tagaaggacg gattcaagta     1500

ccttttccta cacagcggtc agatagcatc agacctgcat tgaacagtcc tgtggaaagg     1560

ccaagcagtg accaggaaga gggagaaact tctgctcaga ccgagcgtgt gccactggac     1620

ctcagtcctc gcctggagga gacgctggac ttcggcgagg tggaagtgga gcccagtgag     1680

gtggaagact tcgaggctcg tgggagccgc ttctccaagt ctgctgatga gagacagcgc     1740

atgctggtgc agcgtaagga cgaactcctc cagcaagctc gcaaacgttt cttgaacaaa     1800

agttctgaag atgatgcggc ctcagagagc ttcctcccct tggaaggtgc gtcctctgac     1860

cccgtgaccc tgcgtcgaag gatgctggct gccgccgcgg aacggaggct tcagaagcag     1920

cagacctcct ag                                                         1932


<210>  53
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Ser Ser Gln Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly 
    1040                 1045                 1050             


Ser Ser  Ser Ser Thr Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu 
    1055                 1060                 1065             


Asp Ile  Asp Met Met Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu 
    1070                 1075                 1080             


Val Glu  Asp Ser Phe Leu 
    1085                 


<210>  54
<211>  3270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  54
atggggactt cccatccggc gttcctggtc ttaggctgtc ttctcacagg gctgagccta       60

atcctctgcc agctttcatt accctctatc cttccaaatg aaaatgaaaa ggttgtgcag      120

ctgaattcat ccttttctct gagatgcttt ggggagagtg aagtgagctg gcagtacccc      180

atgtctgaag aagagagctc cgatgtggaa atcagaaatg aagaaaacaa cagcggcctt      240

tttgtgacgg tcttggaagt gagcagtgcc tcggcggccc acacagggtt gtacacttgc      300

tattacaacc acactcagac agaagagaat gagcttgaag gcaggcacat ttacatctat      360

gtgccagacc cagatgtagc ctttgtacct ctaggaatga cggattattt agtcatcgtg      420

gaggatgatg attctgccat tataccttgt cgcacaactg atcccgagac tcctgtaacc      480

ttacacaaca gtgagggggt ggtacctgcc tcctacgaca gcagacaggg ctttaatggg      540

accttcactg tagggcccta tatctgtgag gccaccgtca aaggaaagaa gttccagacc      600

atcccattta atgtttatgc tttaaaagca acatcagagc tggatctaga aatggaagct      660

cttaaaaccg tgtataagtc aggggaaacg attgtggtca cctgtgctgt ttttaacaat      720

gaggtggttg accttcaatg gacttaccct ggagaagtga aaggcaaagg catcacaatg      780

ctggaagaaa tcaaagtccc atccatcaaa ttggtgtaca ctttgacggt ccccgaggcc      840

acggtgaaag acagtggaga ttacgaatgt gctgcccgcc aggctaccag ggaggtcaaa      900

gaaatgaaga aagtcactat ttctgtccat gagaaaggtt tcattgaaat caaacccacc      960

ttcagccagt tggaagctgt caacctgcat gaagtcaaac attttgttgt agaggtgcgg     1020

gcctacccac ctcccaggat atcctggctg aaaaacaatc tgactctgat tgaaaatctc     1080

actgagatca ccactgatgt ggaaaagatt caggaaataa ggtatcgaag caaattaaag     1140

ctgatccgtg ctaaggaaga agacagtggc cattatacta ttgtagctca aaatgaagat     1200

gctgtgaaga gctatacttt tgaactgtta actcaagttc cttcatccat tctggacttg     1260

gtcgatgatc accatggctc aactggggga cagacggtga ggtgcacagc tgaaggcacg     1320

ccgcttcctg atattgagtg gatgatatgc aaagatatta agaaatgtaa taatgaaact     1380

tcctggacta ttttggccaa caatgtctca aacatcatca cggagatcca ctcccgagac     1440

aggagtaccg tggagggccg tgtgactttc gccaaagtgg aggagaccat cgccgtgcga     1500

tgcctggcta agaatctcct tggagctgag aaccgagagc tgaagctggt ggctcccacc     1560

ctgcgttctg aactcacggt ggctgctgca gtcctggtgc tgttggtgat tgtgatcatc     1620

tcacttattg tcctggttgt catttggaaa cagaaaccga ggtatgaaat tcgctggagg     1680

gtcattgaat caatcagccc agatggacat gaatatattt atgtggaccc gatgcagctg     1740

ccttatgact caagatggga gtttccaaga gatggactag tgcttggtcg ggtcttgggg     1800

tctggagcgt ttgggaaggt ggttgaagga acagcctatg gattaagccg gtcccaacct     1860

gtcatgaaag ttgcagtgaa gatgctaaaa cccacggcca gatccagtga aaaacaagct     1920

ctcatgtctg aactgaagat aatgactcac ctggggccac atttgaacat tgtaaacttg     1980

ctgggagcct gcaccaagtc aggccccatt tacatcatca cagagtattg cttctatgga     2040

gatttggtca actatttgca taagaatagg gatagcttcc tgagccacca cccagagaag     2100

ccaaagaaag agctggatat ctttggattg aaccctgctg atgaaagcac acggagctat     2160

gttattttat cttttgaaaa caatggtgac tacatggaca tgaagcaggc tgatactaca     2220

cagtatgtcc ccatgctaga aaggaaagag gtttctaaat attccgacat ccagagatca     2280

ctctatgatc gtccagcctc atataagaag aaatctatgt tagactcaga agtcaaaaac     2340

ctcctttcag atgataactc agaaggcctt actttattgg atttgttgag cttcacctat     2400

caagttgccc gaggaatgga gtttttggct tcaaaaaatt gtgtccaccg tgatctggct     2460

gctcgcaacg tcctcctggc acaaggaaaa attgtgaaga tctgtgactt tggcctggcc     2520

agagacatca tgcatgattc gaactatgtg tcgaaaggca gtacctttct gcccgtgaag     2580

tggatggctc ctgagagcat ctttgacaac ctctacacca cactgagtga tgtctggtct     2640

tatggcattc tgctctggga gatcttttcc cttggtggca ccccttaccc cggcatgatg     2700

gtggattcta ctttctacaa taagatcaag agtgggtacc ggatggccaa gcctgaccac     2760

gctaccagtg aagtctacga gatcatggtg aaatgctgga acagtgagcc ggagaagaga     2820

ccctcctttt accacctgag tgagattgtg gagaatctgc tgcctggaca atataaaaag     2880

agttatgaaa aaattcacct ggacttcctg aagagtgacc atcctgctgt ggcacgcatg     2940

cgtgtggact cagacaatgc atacattggt gtcacctaca aaaacgagga agacaagctg     3000

aaggactggg agggtggtct ggatgagcag agactgagcg ctgacagtgg ctacatcatt     3060

cctctgcctg acattgaccc tgtccctgag gaggaggacc tgggcaagag gaacagacac     3120

agctcgcaga cctctgaaga gagtgccatt gagacgggtt ccagcagttc caccttcatc     3180

aagagagagg acgagaccat tgaagacatc gacatgatgg atgacatcgg catagactct     3240

tcagacctgg tggaagacag cttcctgtaa                                      3270


<210>  55
<211>  1106
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser  Pro Leu Asp Thr Ser  Ser Val Leu 
        995                 1000                 1005             


Tyr Thr  Ala Val Gln Pro Asn  Glu Gly Asp Asn Asp  Tyr Ile Ile 
    1010                 1015                 1020             


Pro Leu  Pro Asp Pro Lys Pro  Glu Val Ala Asp Glu  Gly Pro Leu 
    1025                 1030                 1035             


Glu Gly  Ser Pro Ser Leu Ala  Ser Ser Thr Leu Asn  Glu Val Asn 
    1040                 1045                 1050             


Thr Ser  Ser Thr Ile Ser Cys  Asp Ser Pro Leu Glu  Pro Gln Asp 
    1055                 1060                 1065             


Glu Pro  Glu Pro Glu Pro Gln  Leu Glu Leu Gln Val  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Leu Glu Gln Leu Pro  Asp Ser Gly Cys Pro  Ala Pro Arg 
    1085                 1090                 1095             


Ala Glu  Ala Glu Asp Ser Phe  Leu 
    1100                 1105     


<210>  56
<211>  3321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  56
atgcggcttc cgggtgcgat gccagctctg gccctcaaag gcgagctgct gttgctgtct       60

ctcctgttac ttctggaacc acagatctct cagggcctgg tcgtcacacc cccggggcca      120

gagcttgtcc tcaatgtctc cagcaccttc gttctgacct gctcgggttc agctccggtg      180

gtgtgggaac ggatgtccca ggagccccca caggaaatgg ccaaggccca ggatggcacc      240

ttctccagcg tgctcacact gaccaacctc actgggctag acacgggaga atacttttgc      300

acccacaatg actcccgtgg actggagacc gatgagcgga aacggctcta catctttgtg      360

ccagatccca ccgtgggctt cctccctaat gatgccgagg aactattcat ctttctcacg      420

gaaataactg agatcaccat tccatgccga gtaacagacc cacagctggt ggtgacactg      480

cacgagaaga aaggggacgt tgcactgcct gtcccctatg atcaccaacg tggcttttct      540

ggtatctttg aggacagaag ctacatctgc aaaaccacca ttggggacag ggaggtggat      600

tctgatgcct actatgtcta cagactccag gtgtcatcca tcaacgtctc tgtgaacgca      660

gtgcagactg tggtccgcca gggtgagaac atcaccctca tgtgcattgt gatcgggaat      720

gaggtggtca acttcgagtg gacatacccc cgcaaagaaa gtgggcggct ggtggagccg      780

gtgactgact tcctcttgga tatgccttac cacatccgct ccatcctgca catccccagt      840

gccgagttag aagactcggg gacctacacc tgcaatgtga cggagagtgt gaatgaccat      900

caggatgaaa aggccatcaa catcaccgtg gttgagagcg gctacgtgcg gctcctggga      960

gaggtgggca cactacaatt tgctgagctg catcggagcc ggacactgca ggtagtgttc     1020

gaggcctacc caccgcccac tgtcctgtgg ttcaaagaca accgcaccct gggcgactcc     1080

agcgctggcg aaatcgccct gtccacgcgc aacgtgtcgg agacccggta tgtgtcagag     1140

ctgacactgg ttcgcgtgaa ggtggcagag gctggccact acaccatgcg ggccttccat     1200

gaggatgctg aggtccagct ctccttccag ctacagatca atgtccctgt ccgagtgctg     1260

gagctaagtg agagccaccc tgacagtggg gaacagacag tccgctgtcg tggccggggc     1320

atgccccagc cgaacatcat ctggtctgcc tgcagagacc tcaaaaggtg tccacgtgag     1380

ctgccgccca cgctgctggg gaacagttcc gaagaggaga gccagctgga gactaacgtg     1440

acgtactggg aggaggagca ggagtttgag gtggtgagca cactgcgtct gcagcacgtg     1500

gatcggccac tgtcggtgcg ctgcacgctg cgcaacgctg tgggccagga cacgcaggag     1560

gtcatcgtgg tgccacactc cttgcccttt aaggtggtgg tgatctcagc catcctggcc     1620

ctggtggtgc tcaccatcat ctcccttatc atcctcatca tgctttggca gaagaagcca     1680

cgttacgaga tccgatggaa ggtgattgag tctgtgagct ctgacggcca tgagtacatc     1740

tacgtggacc ccatgcagct gccctatgac tccacgtggg agctgccgcg ggaccagctt     1800

gtgctgggac gcaccctcgg ctctggggcc tttgggcagg tggtggaggc cacggctcat     1860

ggcctgagcc attctcaggc cacgatgaaa gtggccgtca agatgcttaa atccacagcc     1920

cgcagcagtg agaagcaagc ccttatgtcg gagctgaaga tcatgagtca ccttgggccc     1980

cacctgaacg tggtcaacct gttgggggcc tgcaccaaag gaggacccat ctatatcatc     2040

actgagtact gccgctacgg agacctggtg gactacctgc accgcaacaa acacaccttc     2100

ctgcagcacc actccgacaa gcgccgcccg cccagcgcgg agctctacag caatgctctg     2160

cccgttgggc tccccctgcc cagccatgtg tccttgaccg gggagagcga cggtggctac     2220

atggacatga gcaaggacga gtcggtggac tatgtgccca tgctggacat gaaaggagac     2280

gtcaaatatg cagacatcga gtcctccaac tacatggccc cttacgataa ctacgttccc     2340

tctgcccctg agaggacctg ccgagcaact ttgatcaacg agtctccagt gctaagctac     2400

atggacctcg tgggcttcag ctaccaggtg gccaatggca tggagtttct ggcctccaag     2460

aactgcgtcc acagagacct ggcggctagg aacgtgctca tctgtgaagg caagctggtc     2520

aagatctgtg actttggcct ggctcgagac atcatgcggg actcgaatta catctccaaa     2580

ggcagcacct ttttgccttt aaagtggatg gctccggaga gcatcttcaa cagcctctac     2640

accaccctga gcgacgtgtg gtccttcggg atcctgctct gggagatctt caccttgggt     2700

ggcacccctt acccagagct gcccatgaac gagcagttct acaatgccat caaacggggt     2760

taccgcatgg cccagcctgc ccatgcctcc gacgagatct atgagatcat gcagaagtgc     2820

tgggaagaga agtttgagat tcggcccccc ttctcccagc tggtgctgct tctcgagaga     2880

ctgttgggcg aaggttacaa aaagaagtac cagcaggtgg atgaggagtt tctgaggagt     2940

gaccacccag ccatccttcg gtcccaggcc cgcttgcctg ggttccatgg cctccgatct     3000

cccctggaca ccagctccgt cctctatact gccgtgcagc ccaatgaggg tgacaacgac     3060

tatatcatcc ccctgcctga ccccaaaccc gaggttgctg acgagggccc actggagggt     3120

tcccccagcc tagccagctc caccctgaat gaagtcaaca cctcctcaac catctcctgt     3180

gacagccccc tggagcccca ggacgaacca gagccagagc cccagcttga gctccaggtg     3240

gagccggagc cagagctgga acagttgccg gattcggggt gccctgcgcc tcgggcggaa     3300

gcagaggata gcttcctgta g                                               3321


<210>  57
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Glu Glu Glu Ala Pro Lys Lys Ser Arg Ala Ala Gly Gly Gly 
1               5                   10                  15      


Ala Ser Trp Glu Leu Cys Ala Gly Ala Leu Ser Ala Arg Leu Ala Glu 
            20                  25                  30          


Glu Gly Ser Gly Asp Ala Gly Gly Arg Arg Arg Pro Pro Val Asp Pro 
        35                  40                  45              


Arg Arg Leu Ala Arg Gln Leu Leu Leu Leu Leu Trp Leu Leu Glu Ala 
    50                  55                  60                  


Pro Leu Leu Leu Gly Val Arg Ala Gln Ala Ala Gly Gln Gly Pro Gly 
65                  70                  75                  80  


Gln Gly Pro Gly Pro Gly Gln Gln Pro Pro Pro Pro Pro Gln Gln Gln 
                85                  90                  95      


Gln Ser Gly Gln Gln Tyr Asn Gly Glu Arg Gly Ile Ser Val Pro Asp 
            100                 105                 110         


His Gly Tyr Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala 
        115                 120                 125             


Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr Asn Gln Glu 
    130                 135                 140                 


Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln 
145                 150                 155                 160 


Cys Ser Ala Glu Leu Lys Phe Phe Leu Cys Ser Met Tyr Ala Pro Val 
                165                 170                 175     


Cys Thr Val Leu Glu Gln Ala Leu Pro Pro Cys Arg Ser Leu Cys Glu 
            180                 185                 190         


Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln 
        195                 200                 205             


Trp Pro Asp Thr Leu Lys Cys Glu Lys Phe Pro Val His Gly Ala Gly 
    210                 215                 220                 


Glu Leu Cys Val Gly Gln Asn Thr Ser Asp Lys Gly Thr Pro Thr Pro 
225                 230                 235                 240 


Ser Leu Leu Pro Glu Phe Trp Thr Ser Asn Pro Gln His Gly Gly Gly 
                245                 250                 255     


Gly His Arg Gly Gly Phe Pro Gly Gly Ala Gly Ala Ser Glu Arg Gly 
            260                 265                 270         


Lys Phe Ser Cys Pro Arg Ala Leu Lys Val Pro Ser Tyr Leu Asn Tyr 
        275                 280                 285             


His Phe Leu Gly Glu Lys Asp Cys Gly Ala Pro Cys Glu Pro Thr Lys 
    290                 295                 300                 


Val Tyr Gly Leu Met Tyr Phe Gly Pro Glu Glu Leu Arg Phe Ser Arg 
305                 310                 315                 320 


Thr Trp Ile Gly Ile Trp Ser Val Leu Cys Cys Ala Ser Thr Leu Phe 
                325                 330                 335     


Thr Val Leu Thr Tyr Leu Val Asp Met Arg Arg Phe Ser Tyr Pro Glu 
            340                 345                 350         


Arg Pro Ile Ile Phe Leu Ser Gly Cys Tyr Thr Ala Val Ala Val Ala 
        355                 360                 365             


Tyr Ile Ala Gly Phe Leu Leu Glu Asp Arg Val Val Cys Asn Asp Lys 
    370                 375                 380                 


Phe Ala Glu Asp Gly Ala Arg Thr Val Ala Gln Gly Thr Lys Lys Glu 
385                 390                 395                 400 


Gly Cys Thr Ile Leu Phe Met Met Leu Tyr Phe Phe Ser Met Ala Ser 
                405                 410                 415     


Ser Ile Trp Trp Val Ile Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly 
            420                 425                 430         


Met Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Gln Tyr Phe His 
        435                 440                 445             


Leu Ala Ala Trp Ala Val Pro Ala Ile Lys Thr Ile Thr Ile Leu Ala 
    450                 455                 460                 


Leu Gly Gln Val Asp Gly Asp Val Leu Ser Gly Val Cys Phe Val Gly 
465                 470                 475                 480 


Leu Asn Asn Val Asp Ala Leu Arg Gly Phe Val Leu Ala Pro Leu Phe 
                485                 490                 495     


Val Tyr Leu Phe Ile Gly Thr Ser Phe Leu Leu Ala Gly Phe Val Ser 
            500                 505                 510         


Leu Phe Arg Ile Arg Thr Ile Met Lys His Asp Gly Thr Lys Thr Glu 
        515                 520                 525             


Lys Leu Glu Lys Leu Met Val Arg Ile Gly Val Phe Ser Val Leu Tyr 
    530                 535                 540                 


Thr Val Pro Ala Thr Ile Val Ile Ala Cys Tyr Phe Tyr Glu Gln Ala 
545                 550                 555                 560 


Phe Arg Asp Gln Trp Glu Arg Ser Trp Val Ala Gln Ser Cys Lys Ser 
                565                 570                 575     


Tyr Ala Ile Pro Cys Pro His Leu Gln Ala Gly Gly Gly Ala Pro Pro 
            580                 585                 590         


His Pro Pro Met Ser Pro Asp Phe Thr Val Phe Met Ile Lys Tyr Leu 
        595                 600                 605             


Met Thr Leu Ile Val Gly Ile Thr Ser Gly Phe Trp Ile Trp Ser Gly 
    610                 615                 620                 


Lys Thr Leu Asn Ser Trp Arg Lys Phe Tyr Thr Arg Leu Thr Asn Ser 
625                 630                 635                 640 


Lys Gln Gly Glu Thr Thr Val 
                645         


<210>  58
<211>  1944
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  58
atggctgagg aggaggcgcc taagaagtcc cgggccgccg gcggtggcgc gagctgggaa       60

ctttgtgccg gggcgctctc ggcccggctg gcggaggagg gcagcgggga cgccggtggc      120

cgccgccgcc cgccagttga cccccggcga ttggcgcgcc agctgctgct gctgctttgg      180

ctgctggagg ctccgctgct gctgggggtc cgggcccagg cggcgggcca ggggccaggc      240

caggggcccg ggccggggca gcaaccgccg ccgccgcctc agcagcaaca gagcgggcag      300

cagtacaacg gcgagcgggg catctccgtc ccggaccacg gctattgcca gcccatctcc      360

atcccgctgt gcacggacat cgcgtacaac cagaccatca tgcccaacct gctgggccac      420

acgaaccagg aggacgcggg cctggaggtg caccagttct accctctagt gaaagtgcag      480

tgttccgctg agctcaagtt cttcctgtgc tccatgtacg cgcccgtgtg caccgtgcta      540

gagcaggcgc tgccgccctg ccgctccctg tgcgagcgcg cgcgccaggg ctgcgaggcg      600

ctcatgaaca agttcggctt ccagtggcca gacacgctca agtgtgagaa gttcccggtg      660

cacggcgccg gcgagctgtg cgtgggccag aacacgtccg acaagggcac cccgacgccc      720

tcgctgcttc cagagttctg gaccagcaac cctcagcacg gcggcggagg gcaccgtggc      780

ggcttcccgg ggggcgccgg cgcgtcggag cgaggcaagt tctcctgccc gcgcgccctc      840

aaggtgccct cctacctcaa ctaccacttc ctgggggaga aggactgcgg cgcaccttgt      900

gagccgacca aggtgtatgg gctcatgtac ttcgggcccg aggagctgcg cttctcgcgc      960

acctggattg gcatttggtc agtgctgtgc tgcgcctcca cgctcttcac ggtgcttacg     1020

tacctggtgg acatgcggcg cttcagctac ccggagcggc ccatcatctt cttgtccggc     1080

tgttacacgg ccgtggccgt ggcctacatc gccggcttcc tcctggaaga ccgagtggtg     1140

tgtaatgaca agttcgccga ggacggggca cgcactgtgg cgcagggcac caagaaggag     1200

ggctgcacca tcctcttcat gatgctctac ttcttcagca tggccagctc catctggtgg     1260

gtgatcctgt cgctcacctg gttcctggcg gctggcatga agtggggcca cgaggccatc     1320

gaagccaact cacagtattt tcacctggcc gcctgggctg tgccggccat caagaccatc     1380

accatcctgg cgctgggcca ggtggacggc gatgtgctga gcggagtgtg cttcgtgggg     1440

cttaacaacg tggacgcgct gcgtggcttc gtgctggcgc ccctcttcgt gtacctgttt     1500

atcggcacgt cctttctgct ggccggcttt gtgtcgctct tccgcatccg caccatcatg     1560

aagcacgatg gcaccaagac cgagaagctg gagaagctca tggtgcgcat tggcgtcttc     1620

agcgtgctgt acactgtgcc agccaccatc gtcatcgcct gctacttcta cgagcaggcc     1680

ttccgggacc agtgggaacg cagctgggtg gcccagagct gcaagagcta cgctatcccc     1740

tgccctcacc tccaggcggg cggaggcgcc ccgccgcacc cgcccatgag cccggacttc     1800

acggtcttca tgattaagta ccttatgacg ctgatcgtgg gcatcacgtc gggcttctgg     1860

atctggtccg gcaagaccct caactcctgg aggaagttct acacgaggct caccaacagc     1920

aaacaagggg agactacagt ctga                                            1944


<210>  59
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Arg Pro Arg Ser Ala Leu Pro Arg Leu Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Ala Gly Pro Ala Gln Phe His Gly Glu Lys Gly Ile Ser 
            20                  25                  30          


Ile Pro Asp His Gly Phe Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr 
        35                  40                  45              


Asp Ile Ala Tyr Asn Gln Thr Ile Met Pro Asn Leu Leu Gly His Thr 
    50                  55                  60                  


Asn Gln Glu Asp Ala Gly Leu Glu Val His Gln Phe Tyr Pro Leu Val 
65                  70                  75                  80  


Lys Val Gln Cys Ser Pro Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr 
                85                  90                  95      


Ala Pro Val Cys Thr Val Leu Glu Gln Ala Ile Pro Pro Cys Arg Ser 
            100                 105                 110         


Ile Cys Glu Arg Ala Arg Gln Gly Cys Glu Ala Leu Met Asn Lys Phe 
        115                 120                 125             


Gly Phe Gln Trp Pro Glu Arg Leu Arg Cys Glu His Phe Pro Arg His 
    130                 135                 140                 


Gly Ala Glu Gln Ile Cys Val Gly Gln Asn His Ser Glu Asp Gly Ala 
145                 150                 155                 160 


Pro Ala Leu Leu Thr Thr Ala Pro Pro Pro Gly Leu Gln Pro Gly Ala 
                165                 170                 175     


Gly Gly Thr Pro Gly Gly Pro Gly Gly Gly Gly Ala Pro Pro Arg Tyr 
            180                 185                 190         


Ala Thr Leu Glu His Pro Phe His Cys Pro Arg Val Leu Lys Val Pro 
        195                 200                 205             


Ser Tyr Leu Ser Tyr Lys Phe Leu Gly Glu Arg Asp Cys Ala Ala Pro 
    210                 215                 220                 


Cys Glu Pro Ala Arg Pro Asp Gly Ser Met Phe Phe Ser Gln Glu Glu 
225                 230                 235                 240 


Thr Arg Phe Ala Arg Leu Trp Ile Leu Thr Trp Ser Val Leu Cys Cys 
                245                 250                 255     


Ala Ser Thr Phe Phe Thr Val Thr Thr Tyr Leu Val Asp Met Gln Arg 
            260                 265                 270         


Phe Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Gly Cys Tyr Thr 
        275                 280                 285             


Met Val Ser Val Ala Tyr Ile Ala Gly Phe Val Leu Gln Glu Arg Val 
    290                 295                 300                 


Val Cys Asn Glu Arg Phe Ser Glu Asp Gly Tyr Arg Thr Val Val Gln 
305                 310                 315                 320 


Gly Thr Lys Lys Glu Gly Cys Thr Ile Leu Phe Met Met Leu Tyr Phe 
                325                 330                 335     


Phe Ser Met Ala Ser Ser Ile Trp Trp Val Ile Leu Ser Leu Thr Trp 
            340                 345                 350         


Phe Leu Ala Ala Gly Met Lys Trp Gly His Glu Ala Ile Glu Ala Asn 
        355                 360                 365             


Ser Gln Tyr Phe His Leu Ala Ala Trp Ala Val Pro Ala Val Lys Thr 
    370                 375                 380                 


Ile Thr Ile Leu Ala Met Gly Gln Ile Asp Gly Asp Leu Leu Ser Gly 
385                 390                 395                 400 


Val Cys Phe Val Gly Leu Asn Ser Leu Asp Pro Leu Arg Gly Phe Val 
                405                 410                 415     


Leu Ala Pro Leu Phe Val Tyr Leu Phe Ile Gly Thr Ser Phe Leu Leu 
            420                 425                 430         


Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Thr Ile Met Lys His Asp 
        435                 440                 445             


Gly Thr Lys Thr Glu Lys Leu Glu Arg Leu Met Val Arg Ile Gly Val 
    450                 455                 460                 


Phe Ser Val Leu Tyr Thr Val Pro Ala Thr Ile Val Ile Ala Cys Tyr 
465                 470                 475                 480 


Phe Tyr Glu Gln Ala Phe Arg Glu His Trp Glu Arg Ser Trp Val Ser 
                485                 490                 495     


Gln His Cys Lys Ser Leu Ala Ile Pro Cys Pro Ala His Tyr Thr Pro 
            500                 505                 510         


Arg Met Ser Pro Asp Phe Thr Val Tyr Met Ile Lys Tyr Leu Met Thr 
        515                 520                 525             


Leu Ile Val Gly Ile Thr Ser Gly Phe Trp Ile Trp Ser Gly Lys Thr 
    530                 535                 540                 


Leu His Ser Trp Arg Lys Phe Tyr Thr Arg Leu Thr Asn Ser Arg His 
545                 550                 555                 560 


Gly Glu Thr Thr Val 
                565 


<210>  60
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  60
atgcggcccc gcagcgccct gccccgcctg ctgctgccgc tgctgctgct gcccgccgcc       60

gggccggccc agttccacgg ggagaagggc atctccatcc cggaccacgg cttctgccag      120

cccatctcca tcccgctgtg cacggacatc gcctacaacc agaccatcat gcccaacctt      180

ctgggccaca cgaaccagga ggacgcaggc ctagaggtgc accagttcta tccgctggtg      240

aaggtgcagt gctcgcccga actgcgcttc ttcctgtgct ccatgtacgc acccgtgtgc      300

accgtgctgg aacaggccat cccgccgtgc cgctctatct gtgagcgcgc gcgccagggc      360

tgcgaagccc tcatgaacaa gttcggtttt cagtggcccg agcgcctgcg ctgcgagcac      420

ttcccgcgcc acggcgccga gcagatctgc gtcggccaga accactccga ggacggagct      480

cccgcgctac tcaccaccgc gccgccgccg ggactgcagc cgggtgccgg gggcaccccg      540

ggtggcccgg gcggcggcgg cgctcccccg cgctacgcca cgctggagca ccccttccac      600

tgcccgcgcg tcctcaaggt gccatcctat ctcagctaca agtttctggg cgagcgtgat      660

tgtgctgcgc cctgcgaacc tgcgcggccc gatggttcca tgttcttctc acaggaggag      720

acgcgtttcg cgcgcctctg gatcctcacc tggtcggtgc tgtgctgcgc ttccaccttc      780

ttcactgtca ccacgtactt ggtagacatg cagcgcttcc gctacccaga gcggcctatc      840

atttttctgt cgggctgcta caccatggtg tcggtggcct acatcgcggg cttcgtgctc      900

caggagcgcg tggtgtgcaa cgagcgcttc tccgaggacg gttaccgcac ggtggtgcag      960

ggcaccaaga aggagggctg caccatcctc ttcatgatgc tctacttctt cagcatggcc     1020

agctccatct ggtgggtcat cctgtcgctc acctggttcc tggcagccgg catgaagtgg     1080

ggccacgagg ccatcgaggc caactctcag tacttccacc tggccgcctg ggccgtgccg     1140

gccgtcaaga ccatcaccat cctggccatg ggccagatcg acggcgacct gctgagcggc     1200

gtgtgcttcg taggcctcaa cagcctggac ccgctgcggg gcttcgtgct agcgccgctc     1260

ttcgtgtacc tgttcatcgg cacgtccttc ctcctggccg gcttcgtgtc gctcttccgc     1320

atccgcacca tcatgaagca cgacggcacc aagaccgaaa agctggagcg gctcatggtg     1380

cgcatcggcg tcttctccgt gctctacaca gtgcccgcca ccatcgtcat cgcttgctac     1440

ttctacgagc aggccttccg cgagcactgg gagcgctcgt gggtgagcca gcactgcaag     1500

agcctggcca tcccgtgccc ggcgcactac acgccgcgca tgtcgcccga cttcacggtc     1560

tacatgatca aatacctcat gacgctcatc gtgggcatca cgtcgggctt ctggatctgg     1620

tcgggcaaga cgctgcactc gtggaggaag ttctacactc gcctcaccaa cagccgacac     1680

ggtgagacca ccgtgtga                                                   1698


<210>  61
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Met Thr Trp Ile Val Phe Ser Leu Trp Pro Leu Thr Val Phe 
1               5                   10                  15      


Met Gly His Ile Gly Gly His Ser Leu Phe Ser Cys Glu Pro Ile Thr 
            20                  25                  30          


Leu Arg Met Cys Gln Asp Leu Pro Tyr Asn Thr Thr Phe Met Pro Asn 
        35                  40                  45              


Leu Leu Asn His Tyr Asp Gln Gln Thr Ala Ala Leu Ala Met Glu Pro 
    50                  55                  60                  


Phe His Pro Met Val Asn Leu Asp Cys Ser Arg Asp Phe Arg Pro Phe 
65                  70                  75                  80  


Leu Cys Ala Leu Tyr Ala Pro Ile Cys Met Glu Tyr Gly Arg Val Thr 
                85                  90                  95      


Leu Pro Cys Arg Arg Leu Cys Gln Arg Ala Tyr Ser Glu Cys Ser Lys 
            100                 105                 110         


Leu Met Glu Met Phe Gly Val Pro Trp Pro Glu Asp Met Glu Cys Ser 
        115                 120                 125             


Arg Phe Pro Asp Cys Asp Glu Pro Tyr Pro Arg Leu Val Asp Leu Asn 
    130                 135                 140                 


Leu Ala Gly Glu Pro Thr Glu Gly Ala Pro Val Ala Val Gln Arg Asp 
145                 150                 155                 160 


Tyr Gly Phe Trp Cys Pro Arg Glu Leu Lys Ile Asp Pro Asp Leu Gly 
                165                 170                 175     


Tyr Ser Phe Leu His Val Arg Asp Cys Ser Pro Pro Cys Pro Asn Met 
            180                 185                 190         


Tyr Phe Arg Arg Glu Glu Leu Ser Phe Ala Arg Tyr Phe Ile Gly Leu 
        195                 200                 205             


Ile Ser Ile Ile Cys Leu Ser Ala Thr Leu Phe Thr Phe Leu Thr Phe 
    210                 215                 220                 


Leu Ile Asp Val Thr Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile Phe 
225                 230                 235                 240 


Tyr Ala Val Cys Tyr Met Met Val Ser Leu Ile Phe Phe Ile Gly Phe 
                245                 250                 255     


Leu Leu Glu Asp Arg Val Ala Cys Asn Ala Ser Ile Pro Ala Gln Tyr 
            260                 265                 270         


Lys Ala Ser Thr Val Thr Gln Gly Ser His Asn Lys Ala Cys Thr Met 
        275                 280                 285             


Leu Phe Met Ile Leu Tyr Phe Phe Thr Met Ala Gly Ser Val Trp Trp 
    290                 295                 300                 


Val Ile Leu Thr Ile Thr Trp Phe Leu Ala Ala Val Pro Lys Trp Gly 
305                 310                 315                 320 


Ser Glu Ala Ile Glu Lys Lys Ala Leu Leu Phe His Ala Ser Ala Trp 
                325                 330                 335     


Gly Ile Pro Gly Thr Leu Thr Ile Ile Leu Leu Ala Met Asn Lys Ile 
            340                 345                 350         


Glu Gly Asp Asn Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp Val 
        355                 360                 365             


Asp Ala Leu Arg Tyr Phe Val Leu Ala Pro Leu Cys Leu Tyr Val Val 
    370                 375                 380                 


Val Gly Val Ser Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn Arg Val 
385                 390                 395                 400 


Arg Ile Glu Ile Pro Leu Glu Lys Glu Asn Gln Asp Lys Leu Val Lys 
                405                 410                 415     


Phe Met Ile Arg Ile Gly Val Phe Ser Ile Leu Tyr Leu Val Pro Leu 
            420                 425                 430         


Leu Val Val Ile Gly Cys Tyr Phe Tyr Glu Gln Ala Tyr Arg Gly Ile 
        435                 440                 445             


Trp Glu Thr Thr Trp Ile Gln Glu Arg Cys Arg Glu Tyr His Ile Pro 
    450                 455                 460                 


Cys Pro Tyr Gln Val Thr Gln Met Ser Arg Pro Asp Leu Ile Leu Phe 
465                 470                 475                 480 


Leu Met Lys Tyr Leu Met Ala Leu Ile Val Gly Ile Pro Ser Val Phe 
                485                 490                 495     


Trp Val Gly Ser Lys Lys Thr Cys Phe Glu Trp Ala Ser Phe Phe His 
            500                 505                 510         


Gly Arg Arg Lys Lys Glu Ile Val Asn Glu Ser Arg Gln Val Leu Gln 
        515                 520                 525             


Glu Pro Asp Phe Ala Gln Ser Leu Leu Arg Asp Pro Asn Thr Pro Ile 
    530                 535                 540                 


Ile Arg Lys Ser Arg Gly Thr Ser Thr Gln Gly Thr Ser Thr His Ala 
545                 550                 555                 560 


Ser Ser Thr Gln Leu Ala Met Val Asp Asp Gln Arg Ser Lys Ala Gly 
                565                 570                 575     


Ser Ile His Ser Lys Val Ser Ser Tyr His Gly Ser Leu His Arg Ser 
            580                 585                 590         


Arg Asp Gly Arg Tyr Thr Pro Cys Ser Tyr Arg Gly Met Glu Glu Arg 
        595                 600                 605             


Leu Pro His Gly Ser Met Ser Arg Leu Thr Asp His Ser Arg His Ser 
    610                 615                 620                 


Ser Ser His Arg Leu Asn Glu Gln Ser Arg His Ser Ser Ile Arg Asp 
625                 630                 635                 640 


Leu Ser Asn Asn Pro Met Thr His Ile Thr His Gly Thr Ser Met Asn 
                645                 650                 655     


Arg Val Ile Glu Glu Asp Gly Thr Ser Ala 
            660                 665     


<210>  62
<211>  2001
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  62
atggctatga cttggattgt cttctctctt tggcccttga ctgtgttcat ggggcatata       60

ggtgggcaca gtttgttttc ttgtgaacct attaccttga ggatgtgcca agatttgcct      120

tataatacta ccttcatgcc taatcttctg aatcattatg accaacagac agcagctttg      180

gcaatggagc cattccaccc tatggtgaat ctggattgtt ctcgggattt ccggcctttt      240

ctttgtgcac tctacgctcc tatttgtatg gaatatggac gtgtcacact tccctgtcgt      300

aggctgtgtc agcgggctta cagtgagtgt tcgaagctca tggagatgtt tggtgttcct      360

tggcctgaag atatggaatg cagtaggttc ccagattgtg atgagccata tcctcgactt      420

gtggatctga atttagctgg agaaccaact gaaggagccc cagtggcagt gcagagagac      480

tatggttttt ggtgtccccg agagttaaaa attgatcctg atctgggtta ttcttttctg      540

catgtgcgtg attgttcacc tccttgtcca aatatgtact tcagaagaga agaactgtca      600

tttgctcgct atttcatagg attgatttca atcatttgcc tctcggccac attgtttact      660

tttttaactt ttttgattga tgtcacaaga ttccgttatc ctgaaaggcc tattatattt      720

tatgcagtct gctacatgat ggtatcctta attttcttca ttggattttt gcttgaagat      780

cgagtagcct gcaatgcatc catccctgca caatataagg cttccacagt gacacaagga      840

tctcataata aagcctgtac catgcttttt atgatactct atttttttac tatggctggc      900

agtgtatggt gggtaattct taccatcaca tggtttttag cagctgtgcc aaagtggggt      960

agtgaagcta ttgagaagaa agcattgctg tttcacgcca gtgcatgggg catccccgga     1020

actctaacca tcatcctttt agcgatgaat aaaattgaag gtgacaatat tagtggcgtg     1080

tgttttgttg gcctctacga tgttgatgca ttgagatatt ttgttcttgc tcccctctgc     1140

ctgtatgtgg tagttggggt ttctctcctc ttagctggca ttatatccct aaacagagtt     1200

cgaattgaga ttccattaga aaaggagaac caagataaat tagtgaagtt tatgatccgg     1260

atcggtgttt tcagcattct ttatctcgta ccactcttgg ttgtaattgg atgctacttt     1320

tatgagcaag cttaccgggg catctgggaa acaacgtgga tacaagaacg ctgcagagaa     1380

tatcacattc catgtccata tcaggttact caaatgagtc gtccagactt gattctcttt     1440

ctgatgaaat acctgatggc tctcatagtt ggcattccct ctgtattttg ggttggaagc     1500

aaaaagacat gctttgaatg ggccagtttt tttcatggtc gtaggaaaaa agagatagtg     1560

aatgagagcc gacaggtact ccaggaacct gattttgctc agtctctcct gagggatcca     1620

aatactccta tcataagaaa gtcaagggga acttccactc aaggaacatc cacccatgct     1680

tcttcaactc agctggctat ggtggatgat caaagaagca aagcaggaag catccacagc     1740

aaagtgagca gctaccacgg cagcctccac agatcacgtg atggcaggta cacgccctgc     1800

agttacagag gaatggagga gagactacct catggcagca tgtcacgact aacagatcac     1860

tccaggcata gtagttctca tcggctcaat gaacagtcac gacatagcag catcagagat     1920

ctcagtaata atcccatgac tcatatcaca catggcacca gcatgaatcg ggttattgaa     1980

gaagatggaa ccagtgctta a                                               2001


<210>  63
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Trp Arg Gly Ala Gly Pro Ser Val Pro Gly Ala Pro Gly Gly 
1               5                   10                  15      


Val Gly Leu Ser Leu Gly Leu Leu Leu Gln Leu Leu Leu Leu Leu Gly 
            20                  25                  30          


Pro Ala Arg Gly Phe Gly Asp Glu Glu Glu Arg Arg Cys Asp Pro Ile 
        35                  40                  45              


Arg Ile Ser Met Cys Gln Asn Leu Gly Tyr Asn Val Thr Lys Met Pro 
    50                  55                  60                  


Asn Leu Val Gly His Glu Leu Gln Thr Asp Ala Glu Leu Gln Leu Thr 
65                  70                  75                  80  


Thr Phe Thr Pro Leu Ile Gln Tyr Gly Cys Ser Ser Gln Leu Gln Phe 
                85                  90                  95      


Phe Leu Cys Ser Val Tyr Val Pro Met Cys Thr Glu Lys Ile Asn Ile 
            100                 105                 110         


Pro Ile Gly Pro Cys Gly Gly Met Cys Leu Ser Val Lys Arg Arg Cys 
        115                 120                 125             


Glu Pro Val Leu Lys Glu Phe Gly Phe Ala Trp Pro Glu Ser Leu Asn 
    130                 135                 140                 


Cys Ser Lys Phe Pro Pro Gln Asn Asp His Asn His Met Cys Met Glu 
145                 150                 155                 160 


Gly Pro Gly Asp Glu Glu Val Pro Leu Pro His Lys Thr Pro Ile Gln 
                165                 170                 175     


Pro Gly Glu Glu Cys His Ser Val Gly Thr Asn Ser Asp Gln Tyr Ile 
            180                 185                 190         


Trp Val Lys Arg Ser Leu Asn Cys Val Leu Lys Cys Gly Tyr Asp Ala 
        195                 200                 205             


Gly Leu Tyr Ser Arg Ser Ala Lys Glu Phe Thr Asp Ile Trp Met Ala 
    210                 215                 220                 


Val Trp Ala Ser Leu Cys Phe Ile Ser Thr Ala Phe Thr Val Leu Thr 
225                 230                 235                 240 


Phe Leu Ile Asp Ser Ser Arg Phe Ser Tyr Pro Glu Arg Pro Ile Ile 
                245                 250                 255     


Phe Leu Ser Met Cys Tyr Asn Ile Tyr Ser Ile Ala Tyr Ile Val Arg 
            260                 265                 270         


Leu Thr Val Gly Arg Glu Arg Ile Ser Cys Asp Phe Glu Glu Ala Ala 
        275                 280                 285             


Glu Pro Val Leu Ile Gln Glu Gly Leu Lys Asn Thr Gly Cys Ala Ile 
    290                 295                 300                 


Ile Phe Leu Leu Met Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp 
305                 310                 315                 320 


Val Ile Leu Thr Leu Thr Trp Phe Leu Ala Ala Gly Leu Lys Trp Gly 
                325                 330                 335     


His Glu Ala Ile Glu Met His Ser Ser Tyr Phe His Ile Ala Ala Trp 
            340                 345                 350         


Ala Ile Pro Ala Val Lys Thr Ile Val Ile Leu Ile Met Arg Leu Val 
        355                 360                 365             


Asp Ala Asp Glu Leu Thr Gly Leu Cys Tyr Val Gly Asn Gln Asn Leu 
    370                 375                 380                 


Asp Ala Leu Thr Gly Phe Val Val Ala Pro Leu Phe Thr Tyr Leu Val 
385                 390                 395                 400 


Ile Gly Thr Leu Phe Ile Ala Ala Gly Leu Val Ala Leu Phe Lys Ile 
                405                 410                 415     


Arg Ser Asn Leu Gln Lys Asp Gly Thr Lys Thr Asp Lys Leu Glu Arg 
            420                 425                 430         


Leu Met Val Lys Ile Gly Val Phe Ser Val Leu Tyr Thr Val Pro Ala 
        435                 440                 445             


Thr Cys Val Ile Ala Cys Tyr Phe Tyr Glu Ile Ser Asn Trp Ala Leu 
    450                 455                 460                 


Phe Arg Tyr Ser Ala Asp Asp Ser Asn Met Ala Val Glu Met Leu Lys 
465                 470                 475                 480 


Ile Phe Met Ser Leu Leu Val Gly Ile Thr Ser Gly Met Trp Ile Trp 
                485                 490                 495     


Ser Ala Lys Thr Leu His Thr Trp Gln Lys Cys Ser Asn Arg Leu Val 
            500                 505                 510         


Asn Ser Gly Lys Val Lys Arg Glu Lys Arg Gly Asn Gly Trp Val Lys 
        515                 520                 525             


Pro Gly Lys Gly Ser Glu Thr Val Val 
    530                 535         


<210>  64
<211>  1614
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  64
atggcctggc ggggcgcagg gccgagcgtc ccgggggcgc ccgggggcgt cggtctcagt       60

ctggggttgc tcctgcagtt gctgctgctc ctggggccgg cgcggggctt cggggacgag      120

gaagagcggc gctgcgaccc catccgcatc tccatgtgcc agaacctcgg ctacaacgtg      180

accaagatgc ccaacctggt tgggcacgag ctgcagacgg acgccgagct gcagctgaca      240

actttcacac cgctcatcca gtacggctgc tccagccagc tgcagttctt cctttgttct      300

gtttatgtgc caatgtgcac agagaagatc aacatcccca ttggcccatg cggcggcatg      360

tgtctttcag tcaagagacg ctgtgaaccc gtcctgaagg aatttggatt tgcctggcca      420

gagagtctga actgcagcaa attcccacca cagaacgacc acaaccacat gtgcatggaa      480

gggccaggtg atgaagaggt gcccttacct cacaaaaccc ccatccagcc tggggaagag      540

tgtcactctg tgggaaccaa ttctgatcag tacatctggg tgaaaaggag cctgaactgt      600

gtgctcaagt gtggctatga tgctggctta tacagccgct cagccaagga gttcactgat      660

atctggatgg ctgtgtgggc cagcctgtgt ttcatctcca ctgccttcac agtactgacc      720

ttcctgatcg attcttctag gttttcctac cctgagcgcc ccatcatatt tctcagtatg      780

tgctataata tttatagcat tgcttatatt gtcaggctga ctgtaggccg ggaaaggata      840

tcctgtgatt ttgaagaggc agcagaacct gttctcatcc aagaaggact taagaacaca      900

ggatgtgcaa taattttctt gctgatgtac ttttttggaa tggccagctc catttggtgg      960

gttattctga cactcacttg gtttttggca gcaggactca aatggggtca tgaagccatt     1020

gaaatgcaca gctcttattt ccacattgca gcctgggcca tccccgcagt gaaaaccatt     1080

gtcatcttga ttatgagact ggtggatgca gatgaactga ctggcttgtg ctatgttgga     1140

aaccaaaatc tcgatgccct caccgggttc gtggtggctc ccctctttac ttatttggtc     1200

attggaactt tgttcattgc tgcaggtttg gtggccttgt tcaaaattcg gtcaaatctt     1260

caaaaggatg ggacaaagac agacaagtta gaaagactga tggtcaagat tggggtgttc     1320

tcagtactgt acacagttcc tgcaacgtgt gtgattgcct gttattttta tgaaatctcc     1380

aactgggcac tttttcggta ttctgcagat gattccaaca tggctgttga aatgttgaaa     1440

atttttatgt ctttgttggt gggcatcact tcaggcatgt ggatttggtc tgccaaaact     1500

cttcacacgt ggcagaagtg ttccaacaga ttggtgaatt ctggaaaggt aaagagagag     1560

aagagaggaa atggttgggt gaagcctgga aaaggcagtg agactgtggt ataa           1614


<210>  65
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Arg Pro Asp Pro Ser Ala Pro Pro Ser Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Gln Leu Val Gly Arg Ala Ala Ala Ala Ser Lys Ala Pro Val 
            20                  25                  30          


Cys Gln Glu Ile Thr Val Pro Met Cys Arg Gly Ile Gly Tyr Asn Leu 
        35                  40                  45              


Thr His Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu Ala Gly 
    50                  55                  60                  


Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys Ser Pro 
65                  70                  75                  80  


Asp Leu Arg Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys Leu Pro 
                85                  90                  95      


Asp Tyr His Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu Arg Ala 
            100                 105                 110         


Lys Ala Gly Cys Ser Pro Leu Met Arg Gln Tyr Gly Phe Ala Trp Pro 
        115                 120                 125             


Glu Arg Met Ser Cys Asp Arg Leu Pro Val Leu Gly Arg Asp Ala Glu 
    130                 135                 140                 


Val Leu Cys Met Asp Tyr Asn Arg Ser Glu Ala Thr Thr Ala Pro Pro 
145                 150                 155                 160 


Arg Pro Phe Pro Ala Lys Pro Thr Leu Pro Gly Pro Pro Gly Ala Pro 
                165                 170                 175     


Ala Ser Gly Gly Glu Cys Pro Ala Gly Gly Pro Phe Val Cys Lys Cys 
            180                 185                 190         


Arg Glu Pro Phe Val Pro Ile Leu Lys Glu Ser His Pro Leu Tyr Asn 
        195                 200                 205             


Lys Val Arg Thr Gly Gln Val Pro Asn Cys Ala Val Pro Cys Tyr Gln 
    210                 215                 220                 


Pro Ser Phe Ser Ala Asp Glu Arg Thr Phe Ala Thr Phe Trp Ile Gly 
225                 230                 235                 240 


Leu Trp Ser Val Leu Cys Phe Ile Ser Thr Ser Thr Thr Val Ala Thr 
                245                 250                 255     


Phe Leu Ile Asp Met Glu Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile 
            260                 265                 270         


Phe Leu Ser Ala Cys Tyr Leu Cys Val Ser Leu Gly Phe Leu Val Arg 
        275                 280                 285             


Leu Val Val Gly His Ala Ser Val Ala Cys Ser Arg Glu His Asn His 
    290                 295                 300                 


Ile His Tyr Glu Thr Thr Gly Pro Ala Leu Cys Thr Ile Val Phe Leu 
305                 310                 315                 320 


Leu Val Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp Val Ile Leu 
                325                 330                 335     


Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys Trp Gly Asn Glu Ala 
            340                 345                 350         


Ile Ala Gly Tyr Ala Gln Tyr Phe His Leu Ala Ala Trp Leu Ile Pro 
        355                 360                 365             


Ser Val Lys Ser Ile Thr Ala Leu Ala Leu Ser Ser Val Asp Gly Asp 
    370                 375                 380                 


Pro Val Ala Gly Ile Cys Tyr Val Gly Asn Gln Asn Leu Asn Ser Leu 
385                 390                 395                 400 


Arg Gly Phe Val Leu Gly Pro Leu Val Leu Tyr Leu Leu Val Gly Thr 
                405                 410                 415     


Leu Phe Leu Leu Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Ser Val 
            420                 425                 430         


Ile Lys Gln Gly Gly Thr Lys Thr Asp Lys Leu Glu Lys Leu Met Ile 
        435                 440                 445             


Arg Ile Gly Ile Phe Thr Leu Leu Tyr Thr Val Pro Ala Ser Ile Val 
    450                 455                 460                 


Val Ala Cys Tyr Leu Tyr Glu Gln His Tyr Arg Glu Ser Trp Glu Ala 
465                 470                 475                 480 


Ala Leu Thr Cys Ala Cys Pro Gly His Asp Thr Gly Gln Pro Arg Ala 
                485                 490                 495     


Lys Pro Glu Tyr Trp Val Leu Met Leu Lys Tyr Phe Met Cys Leu Val 
            500                 505                 510         


Val Gly Ile Thr Ser Gly Val Trp Ile Trp Ser Gly Lys Thr Val Glu 
        515                 520                 525             


Ser Trp Arg Arg Phe Thr Ser Arg Cys Cys Cys Arg Pro Arg Arg Gly 
    530                 535                 540                 


His Lys Ser Gly Gly Ala Met Ala Ala Gly Asp Tyr Pro Glu Ala Ser 
545                 550                 555                 560 


Ala Ala Leu Thr Gly Arg Thr Gly Pro Pro Gly Pro Ala Ala Thr Tyr 
                565                 570                 575     


His Lys Gln Val Ser Leu Ser His Val 
            580                 585 


<210>  66
<211>  1758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cNDA

<400>  66
atggctcggc ctgacccatc cgcgccgccc tcgctgttgc tgctgctcct agcgcagctg       60

gtgggccggg cggccgccgc gtccaaggcc ccggtgtgcc aggaaatcac ggtgcccatg      120

tgccgcggca tcggctacaa cctgacgcac atgcccaacc agttcaacca cgacacgcag      180

gacgaggcgg gcctggaggt gcaccagttc tggccgctgg tggagatcca atgctcgccg      240

gacctgcgct tcttcctatg ctctatgtac acgcccatct gtctgcccga ctaccacaag      300

ccgctgccgc cctgccgctc ggtgtgcgag cgcgccaagg ccggctgctc gccgctgatg      360

cgccagtacg gcttcgcctg gcccgagcgc atgagctgcg accgcctccc ggtgctgggc      420

cgcgacgccg aggtcctctg catggattac aaccgcagcg aggccaccac ggcgcccccc      480

aggcctttcc cagccaagcc cacccttcca ggcccgccag gggcgccggc ctcggggggc      540

gaatgccccg ctgggggccc gttcgtgtgc aagtgtcgcg agcccttcgt gcccattctg      600

aaggagtcac acccgctcta caacaaggtg cggacgggcc aggtgcccaa ctgcgcggta      660

ccctgctacc agccgtcctt cagtgccgac gagcgcacgt tcgccacctt ctggataggc      720

ctgtggtcgg tgctgtgctt catctccacg tccaccacag tggccacctt cctcatcgac      780

atggaacgct tccgctatcc tgagcgcccc atcatcttcc tgtcagcctg ctacctgtgc      840

gtgtcgctgg gcttcctggt gcgtctggtc gtgggccatg ccagcgtggc ctgcagccgc      900

gagcacaacc acatccacta cgagaccacg ggccctgcac tgtgcaccat cgtcttcctc      960

ctggtctact tcttcggcat ggccagctcc atctggtggg tcatcctgtc gctcacctgg     1020

ttcctggccg ccggcatgaa gtggggcaac gaggccatcg cgggctacgc gcagtacttc     1080

cacctggctg cgtggctcat ccccagcgtc aagtccatca cggcactggc gctgagctcc     1140

gtggacgggg acccagtggc cggcatctgc tacgtgggca accagaacct gaactcgctg     1200

cgcggcttcg tgctgggccc gctggtgctc tacctgctgg tgggcacgct cttcctgctg     1260

gcgggcttcg tgtcgctctt ccgcatccgc agcgtcatca agcagggcgg caccaagacg     1320

gacaagctgg agaagctcat gatccgcatc ggcatcttca cgctgctcta cacggtcccc     1380

gccagcattg tggtggcctg ctacctgtac gagcagcact accgcgagag ctgggaggcg     1440

gcgctcacct gcgcctgccc gggccacgac accggccagc cgcgcgccaa gcccgagtac     1500

tgggtgctca tgctcaagta cttcatgtgc ctggtggtgg gcatcacgtc gggcgtctgg     1560

atctggtcgg gcaagacggt ggagtcgtgg cggcgtttca ccagccgctg ctgctgccgc     1620

ccgcggcgcg gccacaagag cgggggcgcc atggccgcag gggactaccc cgaggcgagc     1680

gccgcgctca caggcaggac cgggccgccg ggccccgccg ccacctacca caagcaggtg     1740

tccctgtcgc acgtgtag                                                   1758


<210>  67
<211>  706
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Glu Met Phe Thr Phe Leu Leu Thr Cys Ile Phe Leu Pro Leu Leu 
1               5                   10                  15      


Arg Gly His Ser Leu Phe Thr Cys Glu Pro Ile Thr Val Pro Arg Cys 
            20                  25                  30          


Met Lys Met Ala Tyr Asn Met Thr Phe Phe Pro Asn Leu Met Gly His 
        35                  40                  45              


Tyr Asp Gln Ser Ile Ala Ala Val Glu Met Glu His Phe Leu Pro Leu 
    50                  55                  60                  


Ala Asn Leu Glu Cys Ser Pro Asn Ile Glu Thr Phe Leu Cys Lys Ala 
65                  70                  75                  80  


Phe Val Pro Thr Cys Ile Glu Gln Ile His Val Val Pro Pro Cys Arg 
                85                  90                  95      


Lys Leu Cys Glu Lys Val Tyr Ser Asp Cys Lys Lys Leu Ile Asp Thr 
            100                 105                 110         


Phe Gly Ile Arg Trp Pro Glu Glu Leu Glu Cys Asp Arg Leu Gln Tyr 
        115                 120                 125             


Cys Asp Glu Thr Val Pro Val Thr Phe Asp Pro His Thr Glu Phe Leu 
    130                 135                 140                 


Gly Pro Gln Lys Lys Thr Glu Gln Val Gln Arg Asp Ile Gly Phe Trp 
145                 150                 155                 160 


Cys Pro Arg His Leu Lys Thr Ser Gly Gly Gln Gly Tyr Lys Phe Leu 
                165                 170                 175     


Gly Ile Asp Gln Cys Ala Pro Pro Cys Pro Asn Met Tyr Phe Lys Ser 
            180                 185                 190         


Asp Glu Leu Glu Phe Ala Lys Ser Phe Ile Gly Thr Val Ser Ile Phe 
        195                 200                 205             


Cys Leu Cys Ala Thr Leu Phe Thr Phe Leu Thr Phe Leu Ile Asp Val 
    210                 215                 220                 


Arg Arg Phe Arg Tyr Pro Glu Arg Pro Ile Ile Tyr Tyr Ser Val Cys 
225                 230                 235                 240 


Tyr Ser Ile Val Ser Leu Met Tyr Phe Ile Gly Phe Leu Leu Gly Asp 
                245                 250                 255     


Ser Thr Ala Cys Asn Lys Ala Asp Glu Lys Leu Glu Leu Gly Asp Thr 
            260                 265                 270         


Val Val Leu Gly Ser Gln Asn Lys Ala Cys Thr Val Leu Phe Met Leu 
        275                 280                 285             


Leu Tyr Phe Phe Thr Met Ala Gly Thr Val Trp Trp Val Ile Leu Thr 
    290                 295                 300                 


Ile Thr Trp Phe Leu Ala Ala Gly Arg Lys Trp Ser Cys Glu Ala Ile 
305                 310                 315                 320 


Glu Gln Lys Ala Val Trp Phe His Ala Val Ala Trp Gly Thr Pro Gly 
                325                 330                 335     


Phe Leu Thr Val Met Leu Leu Ala Met Asn Lys Val Glu Gly Asp Asn 
            340                 345                 350         


Ile Ser Gly Val Cys Phe Val Gly Leu Tyr Asp Leu Asp Ala Ser Arg 
        355                 360                 365             


Tyr Phe Val Leu Leu Pro Leu Cys Leu Cys Val Phe Val Gly Leu Ser 
    370                 375                 380                 


Leu Leu Leu Ala Gly Ile Ile Ser Leu Asn His Val Arg Gln Val Ile 
385                 390                 395                 400 


Gln His Asp Gly Arg Asn Gln Glu Lys Leu Lys Lys Phe Met Ile Arg 
                405                 410                 415     


Ile Gly Val Phe Ser Gly Leu Tyr Leu Val Pro Leu Val Thr Leu Leu 
            420                 425                 430         


Gly Cys Tyr Val Tyr Glu Gln Val Asn Arg Ile Thr Trp Glu Ile Thr 
        435                 440                 445             


Trp Val Ser Asp His Cys Arg Gln Tyr His Ile Pro Cys Pro Tyr Gln 
    450                 455                 460                 


Ala Lys Ala Lys Ala Arg Pro Glu Leu Ala Leu Phe Met Ile Lys Tyr 
465                 470                 475                 480 


Leu Met Thr Leu Ile Val Gly Ile Ser Ala Val Phe Trp Val Gly Ser 
                485                 490                 495     


Lys Lys Thr Cys Thr Glu Trp Ala Gly Phe Phe Lys Arg Asn Arg Lys 
            500                 505                 510         


Arg Asp Pro Ile Ser Glu Ser Arg Arg Val Leu Gln Glu Ser Cys Glu 
        515                 520                 525             


Phe Phe Leu Lys His Asn Ser Lys Val Lys His Lys Lys Lys His Tyr 
    530                 535                 540                 


Lys Pro Ser Ser His Lys Leu Lys Val Ile Ser Lys Ser Met Gly Thr 
545                 550                 555                 560 


Ser Thr Gly Ala Thr Ala Asn His Gly Thr Ser Ala Val Ala Ile Thr 
                565                 570                 575     


Ser His Asp Tyr Leu Gly Gln Glu Thr Leu Thr Glu Ile Gln Thr Ser 
            580                 585                 590         


Pro Glu Thr Ser Met Arg Glu Val Lys Ala Asp Gly Ala Ser Thr Pro 
        595                 600                 605             


Arg Leu Arg Glu Gln Asp Cys Gly Glu Pro Ala Ser Pro Ala Ala Ser 
    610                 615                 620                 


Ile Ser Arg Leu Ser Gly Glu Gln Val Asp Gly Lys Gly Gln Ala Gly 
625                 630                 635                 640 


Ser Val Ser Glu Ser Ala Arg Ser Glu Gly Arg Ile Ser Pro Lys Ser 
                645                 650                 655     


Asp Ile Thr Asp Thr Gly Leu Ala Gln Ser Asn Asn Leu Gln Val Pro 
            660                 665                 670         


Ser Ser Ser Glu Pro Ser Ser Leu Lys Gly Ser Thr Ser Leu Leu Val 
        675                 680                 685             


His Pro Val Ser Gly Val Arg Lys Glu Gln Gly Gly Gly Cys His Ser 
    690                 695                 700                 


Asp Thr 
705     


<210>  68
<211>  2121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  68
atggaaatgt ttacattttt gttgacgtgt atttttctac ccctcctaag agggcacagt       60

ctcttcacct gtgaaccaat tactgttccc agatgtatga aaatggccta caacatgacg      120

tttttcccta atctgatggg tcattatgac cagagtattg ccgcggtgga aatggagcat      180

tttcttcctc tcgcaaatct ggaatgttca ccaaacattg aaactttcct ctgcaaagca      240

tttgtaccaa cctgcataga acaaattcat gtggttccac cttgtcgtaa actttgtgag      300

aaagtatatt ctgattgcaa aaaattaatt gacacttttg ggatccgatg gcctgaggag      360

cttgaatgtg acagattaca atactgtgat gagactgttc ctgtaacttt tgatccacac      420

acagaatttc ttggtcctca gaagaaaaca gaacaagtcc aaagagacat tggattttgg      480

tgtccaaggc atcttaagac ttctggggga caaggatata agtttctggg aattgaccag      540

tgtgcgcctc catgccccaa catgtatttt aaaagtgatg agctagagtt tgcaaaaagt      600

tttattggaa cagtttcaat attttgtctt tgtgcaactc tgttcacatt ccttactttt      660

ttaattgatg ttagaagatt cagataccca gagagaccaa ttatatatta ctctgtctgt      720

tacagcattg tatctcttat gtacttcatt ggatttttgc taggcgatag cacagcctgc      780

aataaggcag atgagaagct agaacttggt gacactgttg tcctaggctc tcaaaataag      840

gcttgcaccg ttttgttcat gcttttgtat tttttcacaa tggctggcac tgtgtggtgg      900

gtgattctta ccattacttg gttcttagct gcaggaagaa aatggagttg tgaagccatc      960

gagcaaaaag cagtgtggtt tcatgctgtt gcatggggaa caccaggttt cctgactgtt     1020

atgcttcttg ctatgaacaa agttgaagga gacaacatta gtggagtttg ctttgttggc     1080

ctttatgacc tggatgcttc tcgctacttt gtactcttgc cactgtgcct ttgtgtgttt     1140

gttgggctct ctcttctttt agctggcatt atttccttaa atcatgttcg acaagtcata     1200

caacatgatg gccggaacca agaaaaacta aagaaattta tgattcgaat tggagtcttc     1260

agcggcttgt atcttgtgcc attagtgaca cttctcggat gttacgtcta tgagcaagtg     1320

aacaggatta cctgggagat aacttgggtc tctgatcatt gtcgtcagta ccatatccca     1380

tgtccttatc aggcaaaagc aaaagctcga ccagaattgg ctttatttat gataaaatac     1440

ctgatgacat taattgttgg catctctgct gtcttctggg ttggaagcaa aaagacatgc     1500

acagaatggg ctgggttttt taaacgaaat cgcaagagag atccaatcag tgaaagtcga     1560

agagtactac aggaatcatg tgagtttttc ttaaagcaca attctaaagt taaacacaaa     1620

aagaagcact ataaaccaag ttcacacaag ctgaaggtca tttccaaatc catgggaacc     1680

agcacaggag ctacagcaaa tcatggcact tctgcagtag caattactag ccatgattac     1740

ctaggacaag aaactttgac agaaatccaa acctcaccag aaacatcaat gagagaggtg     1800

aaagcggacg gagctagcac ccccaggtta agagaacagg actgtggtga acctgcctcg     1860

ccagcagcat ccatctccag actctctggg gaacaggtcg acgggaaggg ccaggcaggc     1920

agtgtatctg aaagtgcgcg gagtgaagga aggattagtc caaagagtga tattactgac     1980

actggcctgg cacagagcaa caatttgcag gtccccagtt cttcagaacc aagcagcctc     2040

aaaggttcca catctctgct tgttcacccg gtttcaggag tgagaaaaga gcagggaggt     2100

ggttgtcatt cagatacttg a                                               2121


<210>  69
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Arg Asp Pro Gly Ala Ala Ala Pro Leu Ser Ser Leu Gly Leu Cys 
1               5                   10                  15      


Ala Leu Val Leu Ala Leu Leu Gly Ala Leu Ser Ala Gly Ala Gly Ala 
            20                  25                  30          


Gln Pro Tyr His Gly Glu Lys Gly Ile Ser Val Pro Asp His Gly Phe 
        35                  40                  45              


Cys Gln Pro Ile Ser Ile Pro Leu Cys Thr Asp Ile Ala Tyr Asn Gln 
    50                  55                  60                  


Thr Ile Leu Pro Asn Leu Leu Gly His Thr Asn Gln Glu Asp Ala Gly 
65                  70                  75                  80  


Leu Glu Val His Gln Phe Tyr Pro Leu Val Lys Val Gln Cys Ser Pro 
                85                  90                  95      


Glu Leu Arg Phe Phe Leu Cys Ser Met Tyr Ala Pro Val Cys Thr Val 
            100                 105                 110         


Leu Asp Gln Ala Ile Pro Pro Cys Arg Ser Leu Cys Glu Arg Ala Arg 
        115                 120                 125             


Gln Gly Cys Glu Ala Leu Met Asn Lys Phe Gly Phe Gln Trp Pro Glu 
    130                 135                 140                 


Arg Leu Arg Cys Glu Asn Phe Pro Val His Gly Ala Gly Glu Ile Cys 
145                 150                 155                 160 


Val Gly Gln Asn Thr Ser Asp Gly Ser Gly Gly Pro Gly Gly Gly Pro 
                165                 170                 175     


Thr Ala Tyr Pro Thr Ala Pro Tyr Leu Pro Asp Leu Pro Phe Thr Ala 
            180                 185                 190         


Leu Pro Pro Gly Ala Ser Asp Gly Arg Gly Arg Pro Ala Phe Pro Phe 
        195                 200                 205             


Ser Cys Pro Arg Gln Leu Lys Val Pro Pro Tyr Leu Gly Tyr Arg Phe 
    210                 215                 220                 


Leu Gly Glu Arg Asp Cys Gly Ala Pro Cys Glu Pro Gly Arg Ala Asn 
225                 230                 235                 240 


Gly Leu Met Tyr Phe Lys Glu Glu Glu Arg Arg Phe Ala Arg Leu Trp 
                245                 250                 255     


Val Gly Val Trp Ser Val Leu Cys Cys Ala Ser Thr Leu Phe Thr Val 
            260                 265                 270         


Leu Thr Tyr Leu Val Asp Met Arg Arg Phe Ser Tyr Pro Glu Arg Pro 
        275                 280                 285             


Ile Ile Phe Leu Ser Gly Cys Tyr Phe Met Val Ala Val Ala His Val 
    290                 295                 300                 


Ala Gly Phe Leu Leu Glu Asp Arg Ala Val Cys Val Glu Arg Phe Ser 
305                 310                 315                 320 


Asp Asp Gly Tyr Arg Thr Val Ala Gln Gly Thr Lys Lys Glu Gly Cys 
                325                 330                 335     


Thr Ile Leu Phe Met Val Leu Tyr Phe Phe Gly Met Ala Ser Ser Ile 
            340                 345                 350         


Trp Trp Val Ile Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys 
        355                 360                 365             


Trp Gly His Glu Ala Ile Glu Ala Asn Ser Gln Tyr Phe His Leu Ala 
    370                 375                 380                 


Ala Trp Ala Val Pro Ala Val Lys Thr Ile Thr Ile Leu Ala Met Gly 
385                 390                 395                 400 


Gln Val Asp Gly Asp Leu Leu Ser Gly Val Cys Tyr Val Gly Leu Ser 
                405                 410                 415     


Ser Val Asp Ala Leu Arg Gly Phe Val Leu Ala Pro Leu Phe Val Tyr 
            420                 425                 430         


Leu Phe Ile Gly Thr Ser Phe Leu Leu Ala Gly Phe Val Ser Leu Phe 
        435                 440                 445             


Arg Ile Arg Thr Ile Met Lys His Asp Gly Thr Lys Thr Glu Lys Leu 
    450                 455                 460                 


Glu Lys Leu Met Val Arg Ile Gly Val Phe Ser Val Leu Tyr Thr Val 
465                 470                 475                 480 


Pro Ala Thr Ile Val Leu Ala Cys Tyr Phe Tyr Glu Gln Ala Phe Arg 
                485                 490                 495     


Glu His Trp Glu Arg Thr Trp Leu Leu Gln Thr Cys Lys Ser Tyr Ala 
            500                 505                 510         


Val Pro Cys Pro Pro Gly His Phe Pro Pro Met Ser Pro Asp Phe Thr 
        515                 520                 525             


Val Phe Met Ile Lys Tyr Leu Met Thr Met Ile Val Gly Ile Thr Thr 
    530                 535                 540                 


Gly Phe Trp Ile Trp Ser Gly Lys Thr Leu Gln Ser Trp Arg Arg Phe 
545                 550                 555                 560 


Tyr His Arg Leu Ser His Ser Ser Lys Gly Glu Thr Ala Val 
                565                 570                 


<210>  70
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  70
atgcgggacc ccggcgcggc cgctccgctt tcgtccctgg gcctctgtgc cctggtgctg       60

gcgctgctgg gcgcactgtc cgcgggcgcc ggggcgcagc cgtaccacgg agagaagggc      120

atctccgtgc cggaccacgg cttctgccag cccatctcca tcccgctgtg cacggacatc      180

gcctacaacc agaccatcct gcccaacctg ctgggccaca cgaaccaaga ggacgcgggc      240

ctcgaggtgc accagttcta cccgctggtg aaggtgcagt gttctcccga actccgcttt      300

ttcttatgct ccatgtatgc gcccgtgtgc accgtgctcg atcaggccat cccgccgtgt      360

cgttctctgt gcgagcgcgc ccgccagggc tgcgaggcgc tcatgaacaa gttcggcttc      420

cagtggcccg agcggctgcg ctgcgagaac ttcccggtgc acggtgcggg cgagatctgc      480

gtgggccaga acacgtcgga cggctccggg ggcccaggcg gcggccccac tgcctaccct      540

accgcgccct acctgccgga cctgcccttc accgcgctgc ccccgggggc ctcagatggc      600

agggggcgtc ccgccttccc cttctcatgc ccccgtcagc tcaaggtgcc cccgtacctg      660

ggctaccgct tcctgggtga gcgcgattgt ggcgccccgt gcgaaccggg ccgtgccaac      720

ggcctgatgt actttaagga ggaggagagg cgcttcgccc gcctctgggt gggcgtgtgg      780

tccgtgctgt gctgcgcctc gacgctcttt accgttctca cctacctggt ggacatgcgg      840

cgcttcagct acccagagcg gcccatcatc ttcctgtcgg gctgctactt catggtggcc      900

gtggcgcacg tggccggctt ccttctagag gaccgcgccg tgtgcgtgga gcgcttctcg      960

gacgatggct accgcacggt ggcgcagggc accaagaagg agggctgcac catcctcttc     1020

atggtgctct acttcttcgg catggccagc tccatctggt gggtcattct gtctctcact     1080

tggttcctgg cggccggcat gaagtggggc cacgaggcca tcgaggccaa ctcgcagtac     1140

ttccacctgg ccgcgtgggc cgtgcccgcc gtcaagacca tcactatcct ggccatgggc     1200

caggtagacg gggacctgct gagcggggtg tgctacgttg gcctctccag tgtggacgcg     1260

ctgcggggct tcgtgctggc gcctctgttc gtctacctct tcataggcac gtccttcttg     1320

ctggccggct tcgtgtccct cttccgtatc cgcaccatca tgaaacacga cggcaccaag     1380

accgagaagc tggagaagct catggtgcgc atcggcgtct tcagcgtgct ctacacagtg     1440

cccgccacca tcgtcctggc ctgctacttc tacgagcagg ccttccgcga gcactgggag     1500

cgcacctggc tcctgcagac gtgcaagagc tatgccgtgc cctgcccgcc cggccacttc     1560

ccgcccatga gccccgactt caccgtcttc atgatcaagt acctgatgac catgatcgtc     1620

ggcatcacca ctggcttctg gatctggtcg ggcaagaccc tgcagtcgtg gcgccgcttc     1680

taccacagac ttagccacag cagcaagggg gagactgcgg tatga                     1725


<210>  71
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Glu Trp Gly Tyr Leu Leu Glu Val Thr Ser Leu Leu Ala Ala Leu 
1               5                   10                  15      


Ala Leu Leu Gln Arg Ser Ser Gly Ala Ala Ala Ala Ser Ala Lys Glu 
            20                  25                  30          


Leu Ala Cys Gln Glu Ile Thr Val Pro Leu Cys Lys Gly Ile Gly Tyr 
        35                  40                  45              


Asn Tyr Thr Tyr Met Pro Asn Gln Phe Asn His Asp Thr Gln Asp Glu 
    50                  55                  60                  


Ala Gly Leu Glu Val His Gln Phe Trp Pro Leu Val Glu Ile Gln Cys 
65                  70                  75                  80  


Ser Pro Asp Leu Lys Phe Phe Leu Cys Ser Met Tyr Thr Pro Ile Cys 
                85                  90                  95      


Leu Glu Asp Tyr Lys Lys Pro Leu Pro Pro Cys Arg Ser Val Cys Glu 
            100                 105                 110         


Arg Ala Lys Ala Gly Cys Ala Pro Leu Met Arg Gln Tyr Gly Phe Ala 
        115                 120                 125             


Trp Pro Asp Arg Met Arg Cys Asp Arg Leu Pro Glu Gln Gly Asn Pro 
    130                 135                 140                 


Asp Thr Leu Cys Met Asp Tyr Asn Arg Thr Asp Leu Thr Thr Ala Ala 
145                 150                 155                 160 


Pro Ser Pro Pro Arg Arg Leu Pro Pro Pro Pro Pro Gly Glu Gln Pro 
                165                 170                 175     


Pro Ser Gly Ser Gly His Gly Arg Pro Pro Gly Ala Arg Pro Pro His 
            180                 185                 190         


Arg Gly Gly Gly Arg Gly Gly Gly Gly Gly Asp Ala Ala Ala Pro Pro 
        195                 200                 205             


Ala Arg Gly Gly Gly Gly Gly Gly Lys Ala Arg Pro Pro Gly Gly Gly 
    210                 215                 220                 


Ala Ala Pro Cys Glu Pro Gly Cys Gln Cys Arg Ala Pro Met Val Ser 
225                 230                 235                 240 


Val Ser Ser Glu Arg His Pro Leu Tyr Asn Arg Val Lys Thr Gly Gln 
                245                 250                 255     


Ile Ala Asn Cys Ala Leu Pro Cys His Asn Pro Phe Phe Ser Gln Asp 
            260                 265                 270         


Glu Arg Ala Phe Thr Val Phe Trp Ile Gly Leu Trp Ser Val Leu Cys 
        275                 280                 285             


Phe Val Ser Thr Phe Ala Thr Val Ser Thr Phe Leu Ile Asp Met Glu 
    290                 295                 300                 


Arg Phe Lys Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Ala Cys Tyr 
305                 310                 315                 320 


Leu Phe Val Ser Val Gly Tyr Leu Val Arg Leu Val Ala Gly His Glu 
                325                 330                 335     


Lys Val Ala Cys Ser Gly Gly Ala Pro Gly Ala Gly Gly Ala Gly Gly 
            340                 345                 350         


Ala Gly Gly Ala Ala Ala Gly Ala Gly Ala Ala Gly Ala Gly Ala Gly 
        355                 360                 365             


Gly Pro Gly Gly Arg Gly Glu Tyr Glu Glu Leu Gly Ala Val Glu Gln 
    370                 375                 380                 


His Val Arg Tyr Glu Thr Thr Gly Pro Ala Leu Cys Thr Val Val Phe 
385                 390                 395                 400 


Leu Leu Val Tyr Phe Phe Gly Met Ala Ser Ser Ile Trp Trp Val Ile 
                405                 410                 415     


Leu Ser Leu Thr Trp Phe Leu Ala Ala Gly Met Lys Trp Gly Asn Glu 
            420                 425                 430         


Ala Ile Ala Gly Tyr Ser Gln Tyr Phe His Leu Ala Ala Trp Leu Val 
        435                 440                 445             


Pro Ser Val Lys Ser Ile Ala Val Leu Ala Leu Ser Ser Val Asp Gly 
    450                 455                 460                 


Asp Pro Val Ala Gly Ile Cys Tyr Val Gly Asn Gln Ser Leu Asp Asn 
465                 470                 475                 480 


Leu Arg Gly Phe Val Leu Ala Pro Leu Val Ile Tyr Leu Phe Ile Gly 
                485                 490                 495     


Thr Met Phe Leu Leu Ala Gly Phe Val Ser Leu Phe Arg Ile Arg Ser 
            500                 505                 510         


Val Ile Lys Gln Gln Asp Gly Pro Thr Lys Thr His Lys Leu Glu Lys 
        515                 520                 525             


Leu Met Ile Arg Leu Gly Leu Phe Thr Val Leu Tyr Thr Val Pro Ala 
    530                 535                 540                 


Ala Val Val Val Ala Cys Leu Phe Tyr Glu Gln His Asn Arg Pro Arg 
545                 550                 555                 560 


Trp Glu Ala Thr His Asn Cys Pro Cys Leu Arg Asp Leu Gln Pro Asp 
                565                 570                 575     


Gln Ala Arg Arg Pro Asp Tyr Ala Val Phe Met Leu Lys Tyr Phe Met 
            580                 585                 590         


Cys Leu Val Val Gly Ile Thr Ser Gly Val Trp Val Trp Ser Gly Lys 
        595                 600                 605             


Thr Leu Glu Ser Trp Arg Ser Leu Cys Thr Arg Cys Cys Trp Ala Ser 
    610                 615                 620                 


Lys Gly Ala Ala Val Gly Gly Gly Ala Gly Ala Thr Ala Ala Gly Gly 
625                 630                 635                 640 


Gly Gly Gly Pro Gly Gly Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly 
                645                 650                 655     


Gly Pro Gly Gly Gly Gly Gly Ser Leu Tyr Ser Asp Val Ser Thr Gly 
            660                 665                 670         


Leu Thr Trp Arg Ser Gly Thr Ala Ser Ser Val Ser Tyr Pro Lys Gln 
        675                 680                 685             


Met Pro Leu Ser Gln Val 
    690                 


<210>  72
<211>  2085
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  72
atggagtggg gttacctgtt ggaagtgacc tcgctgctgg ccgccttggc gctgctgcag       60

cgctctagcg gcgctgcggc cgcctcggcc aaggagctgg catgccaaga gatcaccgtg      120

ccgctgtgta agggcatcgg ctacaactac acctacatgc ccaatcagtt caaccacgac      180

acgcaagacg aggcgggcct ggaggtgcac cagttctggc cgctggtgga gatccagtgc      240

tcgcccgatc tcaagttctt cctgtgcagc atgtacacgc ccatctgcct agaggactac      300

aagaagccgc tgccgccctg ccgctcggtg tgcgagcgcg ccaaggccgg ctgcgcgccg      360

ctcatgcgcc agtacggctt cgcctggccc gaccgcatgc gctgcgaccg gctgcccgag      420

caaggcaacc ctgacacgct gtgcatggac tacaaccgca ccgacctaac caccgccgcg      480

cccagcccgc cgcgccgcct gccgccgccg ccgcccggcg agcagccgcc ttcgggcagc      540

ggccacggcc gcccgccggg ggccaggccc ccgcaccgcg gcggcggcag gggcggtggc      600

ggcggggacg cggcggcgcc cccagctcgc ggcggcggcg gtggcgggaa ggcgcggccc      660

cctggcggcg gcgcggctcc ctgcgagccc gggtgccagt gccgcgcgcc tatggtgagc      720

gtgtccagcg agcgccaccc gctctacaac cgcgtcaaga caggccagat cgctaactgc      780

gcgctgccct gccacaaccc ctttttcagc caggacgagc gcgccttcac cgtcttctgg      840

atcggcctgt ggtcggtgct ctgcttcgtg tccaccttcg ccaccgtctc caccttcctt      900

atcgacatgg agcgcttcaa gtacccggag cggcccatta tcttcctctc ggcctgctac      960

ctcttcgtgt cggtgggcta cctagtgcgc ctggtggcgg gccacgagaa ggtggcgtgc     1020

agcggtggcg cgccgggcgc ggggggcgct gggggcgcgg gcggcgcggc ggcgggcgcg     1080

ggcgcggcgg gcgcgggcgc gggcggcccg ggcgggcgcg gcgagtacga ggagctgggc     1140

gcggtggagc agcacgtgcg ctacgagacc accggccccg cgctgtgcac cgtggtcttc     1200

ttgctggtct acttcttcgg catggccagc tccatctggt gggtgatctt gtcgctcaca     1260

tggttcctgg cggccggtat gaagtggggc aacgaagcca tcgccggcta ctcgcagtac     1320

ttccacctgg ccgcgtggct tgtgcccagc gtcaagtcca tcgcggtgct ggcgctcagc     1380

tcggtggacg gcgacccggt ggcgggcatc tgctacgtgg gcaaccagag cctggacaac     1440

ctgcgcggct tcgtgctggc gccgctggtc atctacctct tcatcggcac catgttcctg     1500

ctggccggct tcgtgtccct cttccgcatc cgctcggtca tcaagcaaca ggacggcccc     1560

accaagacgc acaagctgga gaagctgatg atccgcctgg gcctgttcac cgtgctctac     1620

accgtgcccg ccgcggtggt ggtcgcctgc ctcttctacg agcagcacaa ccgcccgcgc     1680

tgggaggcca cgcacaactg cccgtgcctg cgggacctgc agcccgacca ggcacgcagg     1740

cccgactacg ccgtcttcat gctcaagtac ttcatgtgcc tagtggtggg catcacctcg     1800

ggcgtgtggg tctggtccgg caagacgctg gagtcctggc gctccctgtg cacccgctgc     1860

tgctgggcca gcaagggcgc cgcggtgggc gggggcgcgg gcgccacggc cgcggggggt     1920

ggcggcgggc cggggggcgg cggcggcggg ggacccggcg gcggcggggg gccgggcggc     1980

ggcgggggct ccctctacag cgacgtcagc actggcctga cgtggcggtc gggcacggcg     2040

agctccgtgt cttatccaaa gcagatgcca ttgtcccagg tctga                     2085


<210>  73
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Val Ala Pro Leu Arg Gly Ala Leu Leu Leu Trp Gln Leu Leu 
1               5                   10                  15      


Ala Ala Gly Gly Ala Ala Leu Glu Ile Gly Arg Phe Asp Pro Glu Arg 
            20                  25                  30          


Gly Arg Gly Ala Ala Pro Cys Gln Ala Val Glu Ile Pro Met Cys Arg 
        35                  40                  45              


Gly Ile Gly Tyr Asn Leu Thr Arg Met Pro Asn Leu Leu Gly His Thr 
    50                  55                  60                  


Ser Gln Gly Glu Ala Ala Ala Glu Leu Ala Glu Phe Ala Pro Leu Val 
65                  70                  75                  80  


Gln Tyr Gly Cys His Ser His Leu Arg Phe Phe Leu Cys Ser Leu Tyr 
                85                  90                  95      


Ala Pro Met Cys Thr Asp Gln Val Ser Thr Pro Ile Pro Ala Cys Arg 
            100                 105                 110         


Pro Met Cys Glu Gln Ala Arg Leu Arg Cys Ala Pro Ile Met Glu Gln 
        115                 120                 125             


Phe Asn Phe Gly Trp Pro Asp Ser Leu Asp Cys Ala Arg Leu Pro Thr 
    130                 135                 140                 


Arg Asn Asp Pro His Ala Leu Cys Met Glu Ala Pro Glu Asn Ala Thr 
145                 150                 155                 160 


Ala Gly Pro Ala Glu Pro His Lys Gly Leu Gly Met Leu Pro Val Ala 
                165                 170                 175     


Pro Arg Pro Ala Arg Pro Pro Gly Asp Leu Gly Pro Gly Ala Gly Gly 
            180                 185                 190         


Ser Gly Thr Cys Glu Asn Pro Glu Lys Phe Gln Tyr Val Glu Lys Ser 
        195                 200                 205             


Arg Ser Cys Ala Pro Arg Cys Gly Pro Gly Val Glu Val Phe Trp Ser 
    210                 215                 220                 


Arg Arg Asp Lys Asp Phe Ala Leu Val Trp Met Ala Val Trp Ser Ala 
225                 230                 235                 240 


Leu Cys Phe Phe Ser Thr Ala Phe Thr Val Leu Thr Phe Leu Leu Glu 
                245                 250                 255     


Pro His Arg Phe Gln Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Met 
            260                 265                 270         


Cys Tyr Asn Val Tyr Ser Leu Ala Phe Leu Ile Arg Ala Val Ala Gly 
        275                 280                 285             


Ala Gln Ser Val Ala Cys Asp Gln Glu Ala Gly Ala Leu Tyr Val Ile 
    290                 295                 300                 


Gln Glu Gly Leu Glu Asn Thr Gly Cys Thr Leu Val Phe Leu Leu Leu 
305                 310                 315                 320 


Tyr Tyr Phe Gly Met Ala Ser Ser Leu Trp Trp Val Val Leu Thr Leu 
                325                 330                 335     


Thr Trp Phe Leu Ala Ala Gly Lys Lys Trp Gly His Glu Ala Ile Glu 
            340                 345                 350         


Ala His Gly Ser Tyr Phe His Met Ala Ala Trp Gly Leu Pro Ala Leu 
        355                 360                 365             


Lys Thr Ile Val Ile Leu Thr Leu Arg Lys Val Ala Gly Asp Glu Leu 
    370                 375                 380                 


Thr Gly Leu Cys Tyr Val Ala Ser Thr Asp Ala Ala Ala Leu Thr Gly 
385                 390                 395                 400 


Phe Val Leu Val Pro Leu Ser Gly Tyr Leu Val Leu Gly Ser Ser Phe 
                405                 410                 415     


Leu Leu Thr Gly Phe Val Ala Leu Phe His Ile Arg Lys Ile Met Lys 
            420                 425                 430         


Thr Gly Gly Thr Asn Thr Glu Lys Leu Glu Lys Leu Met Val Lys Ile 
        435                 440                 445             


Gly Val Phe Ser Ile Leu Tyr Thr Val Pro Ala Thr Cys Val Ile Val 
    450                 455                 460                 


Cys Tyr Val Tyr Glu Arg Leu Asn Met Asp Phe Trp Arg Leu Arg Ala 
465                 470                 475                 480 


Thr Glu Gln Pro Cys Ala Ala Ala Ala Gly Pro Gly Gly Arg Arg Asp 
                485                 490                 495     


Cys Ser Leu Pro Gly Gly Ser Val Pro Thr Val Ala Val Phe Met Leu 
            500                 505                 510         


Lys Ile Phe Met Ser Leu Val Val Gly Ile Thr Ser Gly Val Trp Val 
        515                 520                 525             


Trp Ser Ser Lys Thr Phe Gln Thr Trp Gln Ser Leu Cys Tyr Arg Lys 
    530                 535                 540                 


Ile Ala Ala Gly Arg Ala Arg Ala Lys Ala Cys Arg Ala Pro Gly Ser 
545                 550                 555                 560 


Tyr Gly Arg Gly Thr His Cys His Tyr Lys Ala Pro Thr Val Val Leu 
                565                 570                 575     


His Met Thr Lys Thr Asp Pro Ser Leu Glu Asn Pro Thr His Leu 
            580                 585                 590     


<210>  74
<211>  1776
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  74
atggccgtgg cgcctctgcg gggggcgctg ctgctgtggc agctgctggc ggcgggcggc       60

gcggcactgg agatcggccg cttcgacccg gagcgcgggc gcggggctgc gccgtgccag      120

gcggtggaga tccccatgtg ccgcggcatc ggctacaacc tgacccgcat gcccaacctg      180

ctgggccaca cgtcgcaggg cgaggcggct gccgagctag cggagttcgc gccgctggtg      240

cagtacggct gccacagcca cctgcgcttc ttcctgtgct cgctctacgc gcccatgtgc      300

accgaccagg tctcgacgcc cattcccgcc tgccggccca tgtgcgagca ggcgcgcctg      360

cgctgcgcgc ccatcatgga gcagttcaac ttcggctggc cggactcgct cgactgcgcc      420

cggctgccca cgcgcaacga cccgcacgcg ctgtgcatgg aggcgcccga gaacgccacg      480

gccggccccg cggagcccca caagggcctg ggcatgctgc ccgtggcgcc gcggcccgcg      540

cgccctcccg gagacctggg cccgggcgcg ggcggcagtg gcacctgcga gaaccccgag      600

aagttccagt acgtggagaa gagccgctcg tgcgcaccgc gctgcgggcc cggcgtcgag      660

gtgttctggt cccggcgcga caaggacttc gcgctggtct ggatggccgt gtggtcggcg      720

ctgtgcttct tctccaccgc cttcactgtg ctcaccttct tgctggagcc ccaccgcttc      780

cagtaccccg agcgccccat catcttcctc tccatgtgct acaacgtcta ctcgctggcc      840

ttcctgatcc gtgcggtggc cggagcgcag agcgtggcct gtgaccagga ggcgggcgcg      900

ctctacgtga tccaggaggg cctggagaac acgggctgca cgctggtctt cctactgctc      960

tactacttcg gcatggccag ctcgctctgg tgggtggtcc tgacgctcac ctggttcctg     1020

gctgccggga agaaatgggg ccacgaggcc atcgaggccc acggcagcta tttccacatg     1080

gctgcctggg gcctgcccgc gctcaagacc atcgtcatcc tgaccctgcg caaggtggcg     1140

ggtgatgagc tgactgggct ttgctacgtg gccagcacgg atgcagcagc gctcacgggc     1200

ttcgtgctgg tgcccctctc tggctacctg gtgctgggca gtagtttcct cctgaccggc     1260

ttcgtggccc tcttccacat ccgcaagatc atgaagacgg gcggcaccaa cacagagaag     1320

ctggagaagc tcatggtcaa gatcggggtc ttctccatcc tctacacggt gcccgccacc     1380

tgcgtcatcg tttgctatgt ctacgaacgc ctcaacatgg acttctggcg ccttcgggcc     1440

acagagcagc catgcgcagc ggccgcgggg cccggaggcc ggagggactg ctcgctgcca     1500

gggggctcgg tgcccaccgt ggcggtcttc atgctcaaaa ttttcatgtc actggtggtg     1560

gggatcacca gcggcgtctg ggtgtggagc tccaagactt tccagacctg gcagagcctg     1620

tgctaccgca agatagcagc tggccgggcc cgggccaagg cctgccgcgc ccccgggagc     1680

tacggacgtg gcacgcactg ccactataag gctcccaccg tggtcttgca catgactaag     1740

acggacccct ctttggagaa ccccacacac ctctag                               1776


<210>  75
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Gln Arg Pro Gly Pro Arg Leu Trp Leu Val Leu Gln Val Met Gly 
1               5                   10                  15      


Ser Cys Ala Ala Ile Ser Ser Met Asp Met Glu Arg Pro Gly Asp Gly 
            20                  25                  30          


Lys Cys Gln Pro Ile Glu Ile Pro Met Cys Lys Asp Ile Gly Tyr Asn 
        35                  40                  45              


Met Thr Arg Met Pro Asn Leu Met Gly His Glu Asn Gln Arg Glu Ala 
    50                  55                  60                  


Ala Ile Gln Leu His Glu Phe Ala Pro Leu Val Glu Tyr Gly Cys His 
65                  70                  75                  80  


Gly His Leu Arg Phe Phe Leu Cys Ser Leu Tyr Ala Pro Met Cys Thr 
                85                  90                  95      


Glu Gln Val Ser Thr Pro Ile Pro Ala Cys Arg Val Met Cys Glu Gln 
            100                 105                 110         


Ala Arg Leu Lys Cys Ser Pro Ile Met Glu Gln Phe Asn Phe Lys Trp 
        115                 120                 125             


Pro Asp Ser Leu Asp Cys Arg Lys Leu Pro Asn Lys Asn Asp Pro Asn 
    130                 135                 140                 


Tyr Leu Cys Met Glu Ala Pro Asn Asn Gly Ser Asp Glu Pro Thr Arg 
145                 150                 155                 160 


Gly Ser Gly Leu Phe Pro Pro Leu Phe Arg Pro Gln Arg Pro His Ser 
                165                 170                 175     


Ala Gln Glu His Pro Leu Lys Asp Gly Gly Pro Gly Arg Gly Gly Cys 
            180                 185                 190         


Asp Asn Pro Gly Lys Phe His His Val Glu Lys Ser Ala Ser Cys Ala 
        195                 200                 205             


Pro Leu Cys Thr Pro Gly Val Asp Val Tyr Trp Ser Arg Glu Asp Lys 
    210                 215                 220                 


Arg Phe Ala Val Val Trp Leu Ala Ile Trp Ala Val Leu Cys Phe Phe 
225                 230                 235                 240 


Ser Ser Ala Phe Thr Val Leu Thr Phe Leu Ile Asp Pro Ala Arg Phe 
                245                 250                 255     


Arg Tyr Pro Glu Arg Pro Ile Ile Phe Leu Ser Met Cys Tyr Cys Val 
            260                 265                 270         


Tyr Ser Val Gly Tyr Leu Ile Arg Leu Phe Ala Gly Ala Glu Ser Ile 
        275                 280                 285             


Ala Cys Asp Arg Asp Ser Gly Gln Leu Tyr Val Ile Gln Glu Gly Leu 
    290                 295                 300                 


Glu Ser Thr Gly Cys Thr Leu Val Phe Leu Val Leu Tyr Tyr Phe Gly 
305                 310                 315                 320 


Met Ala Ser Ser Leu Trp Trp Val Val Leu Thr Leu Thr Trp Phe Leu 
                325                 330                 335     


Ala Ala Gly Lys Lys Trp Gly His Glu Ala Ile Glu Ala Asn Ser Ser 
            340                 345                 350         


Tyr Phe His Leu Ala Ala Trp Ala Ile Pro Ala Val Lys Thr Ile Leu 
        355                 360                 365             


Ile Leu Val Met Arg Arg Val Ala Gly Asp Glu Leu Thr Gly Val Cys 
    370                 375                 380                 


Tyr Val Gly Ser Met Asp Val Asn Ala Leu Thr Gly Phe Val Leu Ile 
385                 390                 395                 400 


Pro Leu Ala Cys Tyr Leu Val Ile Gly Thr Ser Phe Ile Leu Ser Gly 
                405                 410                 415     


Phe Val Ala Leu Phe His Ile Arg Arg Val Met Lys Thr Gly Gly Glu 
            420                 425                 430         


Asn Thr Asp Lys Leu Glu Lys Leu Met Val Arg Ile Gly Leu Phe Ser 
        435                 440                 445             


Val Leu Tyr Thr Val Pro Ala Thr Cys Val Ile Ala Cys Tyr Phe Tyr 
    450                 455                 460                 


Glu Arg Leu Asn Met Asp Tyr Trp Lys Ile Leu Ala Ala Gln His Lys 
465                 470                 475                 480 


Cys Lys Met Asn Asn Gln Thr Lys Thr Leu Asp Cys Leu Met Ala Ala 
                485                 490                 495     


Ser Ile Pro Ala Val Glu Ile Phe Met Val Lys Ile Phe Met Leu Leu 
            500                 505                 510         


Val Val Gly Ile Thr Ser Gly Met Trp Ile Trp Thr Ser Lys Thr Leu 
        515                 520                 525             


Gln Ser Trp Gln Gln Val Cys Ser Arg Arg Leu Lys Lys Lys Ser Arg 
    530                 535                 540                 


Arg Lys Pro Ala Ser Val Ile Thr Ser Gly Gly Ile Tyr Lys Lys Ala 
545                 550                 555                 560 


Gln His Pro Gln Lys Thr His His Gly Lys Tyr Glu Ile Pro Ala Gln 
                565                 570                 575     


Ser Pro Thr Cys Val 
            580     


<210>  76
<211>  1746
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  76
atgcagcgcc cgggcccccg cctgtggctg gtcctgcagg tgatgggctc gtgcgccgcc       60

atcagctcca tggacatgga gcgcccgggc gacggcaaat gccagcccat cgagatcccg      120

atgtgcaagg acatcggcta caacatgact cgtatgccca acctgatggg ccacgagaac      180

cagcgcgagg cagccatcca gttgcacgag ttcgcgccgc tggtggagta cggctgccac      240

ggccacctcc gcttcttcct gtgctcgctg tacgcgccga tgtgcaccga gcaggtctct      300

acccccatcc ccgcctgccg ggtcatgtgc gagcaggccc ggctcaagtg ctccccgatt      360

atggagcagt tcaacttcaa gtggcccgac tccctggact gccggaaact ccccaacaag      420

aacgacccca actacctgtg catggaggcg cccaacaacg gctcggacga gcccacccgg      480

ggctcgggcc tgttcccgcc gctgttccgg ccgcagcggc cccacagcgc gcaggagcac      540

ccgctgaagg acgggggccc cgggcgcggc ggctgcgaca acccgggcaa gttccaccac      600

gtggagaaga gcgcgtcgtg cgcgccgctc tgcacgcccg gcgtggacgt gtactggagc      660

cgcgaggaca agcgcttcgc agtggtctgg ctggccatct gggcggtgct gtgcttcttc      720

tccagcgcct tcaccgtgct caccttcctc atcgacccgg cccgcttccg ctaccccgag      780

cgccccatca tcttcctctc catgtgctac tgcgtctact ccgtgggcta cctcatccgc      840

ctcttcgccg gcgccgagag catcgcctgc gaccgggaca gcggccagct ctatgtcatc      900

caggagggac tggagagcac cggctgcacg ctggtcttcc tggtcctcta ctacttcggc      960

atggccagct cgctgtggtg ggtggtcctc acgctcacct ggttcctggc cgccggcaag     1020

aagtggggcc acgaggccat cgaagccaac agcagctact tccacctggc agcctgggcc     1080

atcccggcgg tgaagaccat cctgatcctg gtcatgcgca gggtggcggg ggacgagctc     1140

accggggtct gctacgtggg cagcatggac gtcaacgcgc tcaccggctt cgtgctcatt     1200

cccctggcct gctacctggt catcggcacg tccttcatcc tctcgggctt cgtggccctg     1260

ttccacatcc ggagggtgat gaagacgggc ggcgagaaca cggacaagct ggagaagctc     1320

atggtgcgta tcgggctctt ctctgtgctg tacaccgtgc cggccacctg tgtgatcgcc     1380

tgctactttt acgaacgcct caacatggat tactggaaga tcctggcggc gcagcacaag     1440

tgcaaaatga acaaccagac taaaacgctg gactgcctga tggccgcctc catccccgcc     1500

gtggagatct tcatggtgaa gatctttatg ctgctggtgg tggggatcac cagcgggatg     1560

tggatttgga cctccaagac tctgcagtcc tggcagcagg tgtgcagccg taggttaaag     1620

aagaagagcc ggagaaaacc ggccagcgtg atcaccagcg gtgggattta caaaaaagcc     1680

cagcatcccc agaaaactca ccacgggaaa tatgagatcc ctgcccagtc gcccacctgc     1740

gtgtga                                                                1746


<210>  77
<211>  1615
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Glu Ala Ala Pro Pro Gly Pro Pro Trp Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ala Leu Cys Gly Cys Pro Ala Pro Ala Ala Ala Ser 
            20                  25                  30          


Pro Leu Leu Leu Phe Ala Asn Arg Arg Asp Val Arg Leu Val Asp Ala 
        35                  40                  45              


Gly Gly Val Lys Leu Glu Ser Thr Ile Val Val Ser Gly Leu Glu Asp 
    50                  55                  60                  


Ala Ala Ala Val Asp Phe Gln Phe Ser Lys Gly Ala Val Tyr Trp Thr 
65                  70                  75                  80  


Asp Val Ser Glu Glu Ala Ile Lys Gln Thr Tyr Leu Asn Gln Thr Gly 
                85                  90                  95      


Ala Ala Val Gln Asn Val Val Ile Ser Gly Leu Val Ser Pro Asp Gly 
            100                 105                 110         


Leu Ala Cys Asp Trp Val Gly Lys Lys Leu Tyr Trp Thr Asp Ser Glu 
        115                 120                 125             


Thr Asn Arg Ile Glu Val Ala Asn Leu Asn Gly Thr Ser Arg Lys Val 
    130                 135                 140                 


Leu Phe Trp Gln Asp Leu Asp Gln Pro Arg Ala Ile Ala Leu Asp Pro 
145                 150                 155                 160 


Ala His Gly Tyr Met Tyr Trp Thr Asp Trp Gly Glu Thr Pro Arg Ile 
                165                 170                 175     


Glu Arg Ala Gly Met Asp Gly Ser Thr Arg Lys Ile Ile Val Asp Ser 
            180                 185                 190         


Asp Ile Tyr Trp Pro Asn Gly Leu Thr Ile Asp Leu Glu Glu Gln Lys 
        195                 200                 205             


Leu Tyr Trp Ala Asp Ala Lys Leu Ser Phe Ile His Arg Ala Asn Leu 
    210                 215                 220                 


Asp Gly Ser Phe Arg Gln Lys Val Val Glu Gly Ser Leu Thr His Pro 
225                 230                 235                 240 


Phe Ala Leu Thr Leu Ser Gly Asp Thr Leu Tyr Trp Thr Asp Trp Gln 
                245                 250                 255     


Thr Arg Ser Ile His Ala Cys Asn Lys Arg Thr Gly Gly Lys Arg Lys 
            260                 265                 270         


Glu Ile Leu Ser Ala Leu Tyr Ser Pro Met Asp Ile Gln Val Leu Ser 
        275                 280                 285             


Gln Glu Arg Gln Pro Phe Phe His Thr Arg Cys Glu Glu Asp Asn Gly 
    290                 295                 300                 


Gly Cys Ser His Leu Cys Leu Leu Ser Pro Ser Glu Pro Phe Tyr Thr 
305                 310                 315                 320 


Cys Ala Cys Pro Thr Gly Val Gln Leu Gln Asp Asn Gly Arg Thr Cys 
                325                 330                 335     


Lys Ala Gly Ala Glu Glu Val Leu Leu Leu Ala Arg Arg Thr Asp Leu 
            340                 345                 350         


Arg Arg Ile Ser Leu Asp Thr Pro Asp Phe Thr Asp Ile Val Leu Gln 
        355                 360                 365             


Val Asp Asp Ile Arg His Ala Ile Ala Ile Asp Tyr Asp Pro Leu Glu 
    370                 375                 380                 


Gly Tyr Val Tyr Trp Thr Asp Asp Glu Val Arg Ala Ile Arg Arg Ala 
385                 390                 395                 400 


Tyr Leu Asp Gly Ser Gly Ala Gln Thr Leu Val Asn Thr Glu Ile Asn 
                405                 410                 415     


Asp Pro Asp Gly Ile Ala Val Asp Trp Val Ala Arg Asn Leu Tyr Trp 
            420                 425                 430         


Thr Asp Thr Gly Thr Asp Arg Ile Glu Val Thr Arg Leu Asn Gly Thr 
        435                 440                 445             


Ser Arg Lys Ile Leu Val Ser Glu Asp Leu Asp Glu Pro Arg Ala Ile 
    450                 455                 460                 


Ala Leu His Pro Val Met Gly Leu Met Tyr Trp Thr Asp Trp Gly Glu 
465                 470                 475                 480 


Asn Pro Lys Ile Glu Cys Ala Asn Leu Asp Gly Gln Glu Arg Arg Val 
                485                 490                 495     


Leu Val Asn Ala Ser Leu Gly Trp Pro Asn Gly Leu Ala Leu Asp Leu 
            500                 505                 510         


Gln Glu Gly Lys Leu Tyr Trp Gly Asp Ala Lys Thr Asp Lys Ile Glu 
        515                 520                 525             


Val Ile Asn Val Asp Gly Thr Lys Arg Arg Thr Leu Leu Glu Asp Lys 
    530                 535                 540                 


Leu Pro His Ile Phe Gly Phe Thr Leu Leu Gly Asp Phe Ile Tyr Trp 
545                 550                 555                 560 


Thr Asp Trp Gln Arg Arg Ser Ile Glu Arg Val His Lys Val Lys Ala 
                565                 570                 575     


Ser Arg Asp Val Ile Ile Asp Gln Leu Pro Asp Leu Met Gly Leu Lys 
            580                 585                 590         


Ala Val Asn Val Ala Lys Val Val Gly Thr Asn Pro Cys Ala Asp Arg 
        595                 600                 605             


Asn Gly Gly Cys Ser His Leu Cys Phe Phe Thr Pro His Ala Thr Arg 
    610                 615                 620                 


Cys Gly Cys Pro Ile Gly Leu Glu Leu Leu Ser Asp Met Lys Thr Cys 
625                 630                 635                 640 


Ile Val Pro Glu Ala Phe Leu Val Phe Thr Ser Arg Ala Ala Ile His 
                645                 650                 655     


Arg Ile Ser Leu Glu Thr Asn Asn Asn Asp Val Ala Ile Pro Leu Thr 
            660                 665                 670         


Gly Val Lys Glu Ala Ser Ala Leu Asp Phe Asp Val Ser Asn Asn His 
        675                 680                 685             


Ile Tyr Trp Thr Asp Val Ser Leu Lys Thr Ile Ser Arg Ala Phe Met 
    690                 695                 700                 


Asn Gly Ser Ser Val Glu His Val Val Glu Phe Gly Leu Asp Tyr Pro 
705                 710                 715                 720 


Glu Gly Met Ala Val Asp Trp Met Gly Lys Asn Leu Tyr Trp Ala Asp 
                725                 730                 735     


Thr Gly Thr Asn Arg Ile Glu Val Ala Arg Leu Asp Gly Gln Phe Arg 
            740                 745                 750         


Gln Val Leu Val Trp Arg Asp Leu Asp Asn Pro Arg Ser Leu Ala Leu 
        755                 760                 765             


Asp Pro Thr Lys Gly Tyr Ile Tyr Trp Thr Glu Trp Gly Gly Lys Pro 
    770                 775                 780                 


Arg Ile Val Arg Ala Phe Met Asp Gly Thr Asn Cys Met Thr Leu Val 
785                 790                 795                 800 


Asp Lys Val Gly Arg Ala Asn Asp Leu Thr Ile Asp Tyr Ala Asp Gln 
                805                 810                 815     


Arg Leu Tyr Trp Thr Asp Leu Asp Thr Asn Met Ile Glu Ser Ser Asn 
            820                 825                 830         


Met Leu Gly Gln Glu Arg Val Val Ile Ala Asp Asp Leu Pro His Pro 
        835                 840                 845             


Phe Gly Leu Thr Gln Tyr Ser Asp Tyr Ile Tyr Trp Thr Asp Trp Asn 
    850                 855                 860                 


Leu His Ser Ile Glu Arg Ala Asp Lys Thr Ser Gly Arg Asn Arg Thr 
865                 870                 875                 880 


Leu Ile Gln Gly His Leu Asp Phe Val Met Asp Ile Leu Val Phe His 
                885                 890                 895     


Ser Ser Arg Gln Asp Gly Leu Asn Asp Cys Met His Asn Asn Gly Gln 
            900                 905                 910         


Cys Gly Gln Leu Cys Leu Ala Ile Pro Gly Gly His Arg Cys Gly Cys 
        915                 920                 925             


Ala Ser His Tyr Thr Leu Asp Pro Ser Ser Arg Asn Cys Ser Pro Pro 
    930                 935                 940                 


Thr Thr Phe Leu Leu Phe Ser Gln Lys Ser Ala Ile Ser Arg Met Ile 
945                 950                 955                 960 


Pro Asp Asp Gln His Ser Pro Asp Leu Ile Leu Pro Leu His Gly Leu 
                965                 970                 975     


Arg Asn Val Lys Ala Ile Asp Tyr Asp Pro Leu Asp Lys Phe Ile Tyr 
            980                 985                 990         


Trp Val Asp Gly Arg Gln Asn Ile  Lys Arg Ala Lys Asp  Asp Gly Thr 
        995                 1000                 1005             


Gln Pro  Phe Val Leu Thr Ser  Leu Ser Gln Gly Gln  Asn Pro Asp 
    1010                 1015                 1020             


Arg Gln  Pro His Asp Leu Ser  Ile Asp Ile Tyr Ser  Arg Thr Leu 
    1025                 1030                 1035             


Phe Trp  Thr Cys Glu Ala Thr  Asn Thr Ile Asn Val  His Arg Leu 
    1040                 1045                 1050             


Ser Gly  Glu Ala Met Gly Val  Val Leu Arg Gly Asp  Arg Asp Lys 
    1055                 1060                 1065             


Pro Arg  Ala Ile Val Val Asn  Ala Glu Arg Gly Tyr  Leu Tyr Phe 
    1070                 1075                 1080             


Thr Asn  Met Gln Asp Arg Ala  Ala Lys Ile Glu Arg  Ala Ala Leu 
    1085                 1090                 1095             


Asp Gly  Thr Glu Arg Glu Val  Leu Phe Thr Thr Gly  Leu Ile Arg 
    1100                 1105                 1110             


Pro Val  Ala Leu Val Val Asp  Asn Thr Leu Gly Lys  Leu Phe Trp 
    1115                 1120                 1125             


Val Asp  Ala Asp Leu Lys Arg  Ile Glu Ser Cys Asp  Leu Ser Gly 
    1130                 1135                 1140             


Ala Asn  Arg Leu Thr Leu Glu  Asp Ala Asn Ile Val  Gln Pro Leu 
    1145                 1150                 1155             


Gly Leu  Thr Ile Leu Gly Lys  His Leu Tyr Trp Ile  Asp Arg Gln 
    1160                 1165                 1170             


Gln Gln  Met Ile Glu Arg Val  Glu Lys Thr Thr Gly  Asp Lys Arg 
    1175                 1180                 1185             


Thr Arg  Ile Gln Gly Arg Val  Ala His Leu Thr Gly  Ile His Ala 
    1190                 1195                 1200             


Val Glu  Glu Val Ser Leu Glu  Glu Phe Ser Ala His  Pro Cys Ala 
    1205                 1210                 1215             


Arg Asp  Asn Gly Gly Cys Ser  His Ile Cys Ile Ala  Lys Gly Asp 
    1220                 1225                 1230             


Gly Thr  Pro Arg Cys Ser Cys  Pro Val His Leu Val  Leu Leu Gln 
    1235                 1240                 1245             


Asn Leu  Leu Thr Cys Gly Glu  Pro Pro Thr Cys Ser  Pro Asp Gln 
    1250                 1255                 1260             


Phe Ala  Cys Ala Thr Gly Glu  Ile Asp Cys Ile Pro  Gly Ala Trp 
    1265                 1270                 1275             


Arg Cys  Asp Gly Phe Pro Glu  Cys Asp Asp Gln Ser  Asp Glu Glu 
    1280                 1285                 1290             


Gly Cys  Pro Val Cys Ser Ala  Ala Gln Phe Pro Cys  Ala Arg Gly 
    1295                 1300                 1305             


Gln Cys  Val Asp Leu Arg Leu  Arg Cys Asp Gly Glu  Ala Asp Cys 
    1310                 1315                 1320             


Gln Asp  Arg Ser Asp Glu Val  Asp Cys Asp Ala Ile  Cys Leu Pro 
    1325                 1330                 1335             


Asn Gln  Phe Arg Cys Ala Ser  Gly Gln Cys Val Leu  Ile Lys Gln 
    1340                 1345                 1350             


Gln Cys  Asp Ser Phe Pro Asp  Cys Ile Asp Gly Ser  Asp Glu Leu 
    1355                 1360                 1365             


Met Cys  Glu Ile Thr Lys Pro  Pro Ser Asp Asp Ser  Pro Ala His 
    1370                 1375                 1380             


Ser Ser  Ala Ile Gly Pro Val  Ile Gly Ile Ile Leu  Ser Leu Phe 
    1385                 1390                 1395             


Val Met  Gly Gly Val Tyr Phe  Val Cys Gln Arg Val  Val Cys Gln 
    1400                 1405                 1410             


Arg Tyr  Ala Gly Ala Asn Gly  Pro Phe Pro His Glu  Tyr Val Ser 
    1415                 1420                 1425             


Gly Thr  Pro His Val Pro Leu  Asn Phe Ile Ala Pro  Gly Gly Ser 
    1430                 1435                 1440             


Gln His  Gly Pro Phe Thr Gly  Ile Ala Cys Gly Lys  Ser Met Met 
    1445                 1450                 1455             


Ser Ser  Val Ser Leu Met Gly  Gly Arg Gly Gly Val  Pro Leu Tyr 
    1460                 1465                 1470             


Asp Arg  Asn His Val Thr Gly  Ala Ser Ser Ser Ser  Ser Ser Ser 
    1475                 1480                 1485             


Thr Lys  Ala Thr Leu Tyr Pro  Pro Ile Leu Asn Pro  Pro Pro Ser 
    1490                 1495                 1500             


Pro Ala  Thr Asp Pro Ser Leu  Tyr Asn Met Asp Met  Phe Tyr Ser 
    1505                 1510                 1515             


Ser Asn  Ile Pro Ala Thr Ala  Arg Pro Tyr Arg Pro  Tyr Ile Ile 
    1520                 1525                 1530             


Arg Gly  Met Ala Pro Pro Thr  Thr Pro Cys Ser Thr  Asp Val Cys 
    1535                 1540                 1545             


Asp Ser  Asp Tyr Ser Ala Ser  Arg Trp Lys Ala Ser  Lys Tyr Tyr 
    1550                 1555                 1560             


Leu Asp  Leu Asn Ser Asp Ser  Asp Pro Tyr Pro Pro  Pro Pro Thr 
    1565                 1570                 1575             


Pro His  Ser Gln Tyr Leu Ser  Ala Glu Asp Ser Cys  Pro Pro Ser 
    1580                 1585                 1590             


Pro Ala  Thr Glu Arg Ser Tyr  Phe His Leu Phe Pro  Pro Pro Pro 
    1595                 1600                 1605             


Ser Pro  Cys Thr Asp Ser Ser  
    1610                 1615 


<210>  78
<211>  4848
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  78
atggaggcag cgccgcccgg gccgccgtgg ccgctgctgc tgctgctgct gctgctgctg       60

gcgctgtgcg gctgcccggc ccccgccgcg gcctcgccgc tcctgctatt tgccaaccgc      120

cgggacgtac ggctggtgga cgccggcgga gtcaagctgg agtccaccat cgtggtcagc      180

ggcctggagg atgcggccgc agtggacttc cagttttcca agggagccgt gtactggaca      240

gacgtgagcg aggaggccat caagcagacc tacctgaacc agacgggggc cgccgtgcag      300

aacgtggtca tctccggcct ggtctctccc gacggcctcg cctgcgactg ggtgggcaag      360

aagctgtact ggacggactc agagaccaac cgcatcgagg tggccaacct caatggcaca      420

tcccggaagg tgctcttctg gcaggacctt gaccagccga gggccatcgc cttggacccc      480

gctcacgggt acatgtactg gacagactgg ggtgagacgc cccggattga gcgggcaggg      540

atggatggca gcacccggaa gatcattgtg gactcggaca tttactggcc caatggactg      600

accatcgacc tggaggagca gaagctctac tgggctgacg ccaagctcag cttcatccac      660

cgtgccaacc tggacggctc gttccggcag aaggtggtgg agggcagcct gacgcacccc      720

ttcgccctga cgctctccgg ggacactctg tactggacag actggcagac ccgctccatc      780

catgcctgca acaagcgcac tggggggaag aggaaggaga tcctgagtgc cctctactca      840

cccatggaca tccaggtgct gagccaggag cggcagcctt tcttccacac tcgctgtgag      900

gaggacaatg gcggctgctc ccacctgtgc ctgctgtccc caagcgagcc tttctacaca      960

tgcgcctgcc ccacgggtgt gcagctgcag gacaacggca ggacgtgtaa ggcaggagcc     1020

gaggaggtgc tgctgctggc ccggcggacg gacctacgga ggatctcgct ggacacgccg     1080

gacttcaccg acatcgtgct gcaggtggac gacatccggc acgccattgc catcgactac     1140

gacccgctag agggctatgt ctactggaca gatgacgagg tgcgggccat ccgcagggcg     1200

tacctggacg ggtctggggc gcagacgctg gtcaacaccg agatcaacga ccccgatggc     1260

atcgcggtcg actgggtggc ccgaaacctc tactggaccg acacgggcac ggaccgcatc     1320

gaggtgacgc gcctcaacgg cacctcccgc aagatcctgg tgtcggagga cctggacgag     1380

ccccgagcca tcgcactgca ccccgtgatg ggcctcatgt actggacaga ctggggagag     1440

aaccctaaaa tcgagtgtgc caacttggat gggcaggagc ggcgtgtgct ggtcaatgcc     1500

tccctcgggt ggcccaacgg cctggccctg gacctgcagg aggggaagct ctactgggga     1560

gacgccaaga cagacaagat cgaggtgatc aatgttgatg ggacgaagag gcggaccctc     1620

ctggaggaca agctcccgca cattttcggg ttcacgctgc tgggggactt catctactgg     1680

actgactggc agcgccgcag catcgagcgg gtgcacaagg tcaaggccag ccgggacgtc     1740

atcattgacc agctgcccga cctgatgggg ctcaaagctg tgaatgtggc caaggtcgtc     1800

ggaaccaacc cgtgtgcgga caggaacggg gggtgcagcc acctgtgctt cttcacaccc     1860

cacgcaaccc ggtgtggctg ccccatcggc ctggagctgc tgagtgacat gaagacctgc     1920

atcgtgcctg aggccttctt ggtcttcacc agcagagccg ccatccacag gatctccctc     1980

gagaccaata acaacgacgt ggccatcccg ctcacgggcg tcaaggaggc ctcagccctg     2040

gactttgatg tgtccaacaa ccacatttac tggacagacg tcagcctgaa gaccatcagc     2100

cgcgccttca tgaacgggag ctcggtggag cacgtggtgg agtttggcct tgactacccc     2160

gagggcatgg ccgttgactg gatgggcaag aacctctact gggccgacac tgggaccaat     2220

agaatcgaag tggcgcggct ggacgggcag ttccggcaag tcctcgtgtg gagggacttg     2280

gacaacccga ggtcgctggc cctggatccc accaagggct acatctactg gaccgagtgg     2340

ggcggcaagc cgaggatcgt gcgggccttc atggacggga ccaactgcat gacgctggtg     2400

gacaaggtgg gccgggccaa cgacctcacc attgactacg ctgaccagcg cctctactgg     2460

accgacctgg acaccaacat gatcgagtcg tccaacatgc tgggtcagga gcgggtcgtg     2520

attgccgacg atctcccgca cccgttcggt ctgacgcagt acagcgatta tatctactgg     2580

acagactgga atctgcacag cattgagcgg gccgacaaga ctagcggccg gaaccgcacc     2640

ctcatccagg gccacctgga cttcgtgatg gacatcctgg tgttccactc ctcccgccag     2700

gatggcctca atgactgtat gcacaacaac gggcagtgtg ggcagctgtg ccttgccatc     2760

cccggcggcc accgctgcgg ctgcgcctca cactacaccc tggaccccag cagccgcaac     2820

tgcagcccgc ccaccacctt cttgctgttc agccagaaat ctgccatcag tcggatgatc     2880

ccggacgacc agcacagccc ggatctcatc ctgcccctgc atggactgag gaacgtcaaa     2940

gccatcgact atgacccact ggacaagttc atctactggg tggatgggcg ccagaacatc     3000

aagcgagcca aggacgacgg gacccagccc tttgttttga cctctctgag ccaaggccaa     3060

aacccagaca ggcagcccca cgacctcagc atcgacatct acagccggac actgttctgg     3120

acgtgcgagg ccaccaatac catcaacgtc cacaggctga gcggggaagc catgggggtg     3180

gtgctgcgtg gggaccgcga caagcccagg gccatcgtcg tcaacgcgga gcgagggtac     3240

ctgtacttca ccaacatgca ggaccgggca gccaagatcg aacgcgcagc cctggacggc     3300

accgagcgcg aggtcctctt caccaccggc ctcatccgcc ctgtggccct ggtggtggac     3360

aacacactgg gcaagctgtt ctgggtggac gcggacctga agcgcattga gagctgtgac     3420

ctgtcagggg ccaaccgcct gaccctggag gacgccaaca tcgtgcagcc tctgggcctg     3480

accatccttg gcaagcatct ctactggatc gaccgccagc agcagatgat cgagcgtgtg     3540

gagaagacca ccggggacaa gcggactcgc atccagggcc gtgtcgccca cctcactggc     3600

atccatgcag tggaggaagt cagcctggag gagttctcag cccacccatg tgcccgtgac     3660

aatggtggct gctcccacat ctgtattgcc aagggtgatg ggacaccacg gtgctcatgc     3720

ccagtccacc tcgtgctcct gcagaacctg ctgacctgtg gagagccgcc cacctgctcc     3780

ccggaccagt ttgcatgtgc cacaggggag atcgactgta tccccggggc ctggcgctgt     3840

gacggctttc ccgagtgcga tgaccagagc gacgaggagg gctgccccgt gtgctccgcc     3900

gcccagttcc cctgcgcgcg gggtcagtgt gtggacctgc gcctgcgctg cgacggcgag     3960

gcagactgtc aggaccgctc agacgaggtg gactgtgacg ccatctgcct gcccaaccag     4020

ttccggtgtg cgagcggcca gtgtgtcctc atcaaacagc agtgcgactc cttccccgac     4080

tgtatcgacg gctccgacga gctcatgtgt gaaatcacca agccgccctc agacgacagc     4140

ccggcccaca gcagtgccat cgggcccgtc attggcatca tcctctctct cttcgtcatg     4200

ggtggtgtct attttgtgtg ccagcgcgtg gtgtgccagc gctatgcggg ggccaacggg     4260

cccttcccgc acgagtatgt cagcgggacc ccgcacgtgc ccctcaattt catagccccg     4320

ggcggttccc agcatggccc cttcacaggc atcgcatgcg gaaagtccat gatgagctcc     4380

gtgagcctga tggggggccg gggcggggtg cccctctacg accggaacca cgtcacaggg     4440

gcctcgtcca gcagctcgtc cagcacgaag gccacgctgt acccgccgat cctgaacccg     4500

ccgccctccc cggccacgga cccctccctg tacaacatgg acatgttcta ctcttcaaac     4560

attccggcca ctgcgagacc gtacaggccc tacatcattc gaggaatggc gcccccgacg     4620

acgccctgca gcaccgacgt gtgtgacagc gactacagcg ccagccgctg gaaggccagc     4680

aagtactacc tggatttgaa ctcggactca gacccctatc cacccccacc cacgccccac     4740

agccagtacc tgtcggcgga ggacagctgc ccgccctcgc ccgccaccga gaggagctac     4800

ttccatctct tcccgccccc tccgtccccc tgcacggact catcctga                  4848


<210>  79
<211>  1613
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Gly Ala Val Leu Arg Ser Leu Leu Ala Cys Ser Phe Cys Val Leu 
1               5                   10                  15      


Leu Arg Ala Ala Pro Leu Leu Leu Tyr Ala Asn Arg Arg Asp Leu Arg 
            20                  25                  30          


Leu Val Asp Ala Thr Asn Gly Lys Glu Asn Ala Thr Ile Val Val Gly 
        35                  40                  45              


Gly Leu Glu Asp Ala Ala Ala Val Asp Phe Val Phe Ser His Gly Leu 
    50                  55                  60                  


Ile Tyr Trp Ser Asp Val Ser Glu Glu Ala Ile Lys Arg Thr Glu Phe 
65                  70                  75                  80  


Asn Lys Thr Glu Ser Val Gln Asn Val Val Val Ser Gly Leu Leu Ser 
                85                  90                  95      


Pro Asp Gly Leu Ala Cys Asp Trp Leu Gly Glu Lys Leu Tyr Trp Thr 
            100                 105                 110         


Asp Ser Glu Thr Asn Arg Ile Glu Val Ser Asn Leu Asp Gly Ser Leu 
        115                 120                 125             


Arg Lys Val Leu Phe Trp Gln Glu Leu Asp Gln Pro Arg Ala Ile Ala 
    130                 135                 140                 


Leu Asp Pro Ser Ser Gly Phe Met Tyr Trp Thr Asp Trp Gly Glu Val 
145                 150                 155                 160 


Pro Lys Ile Glu Arg Ala Gly Met Asp Gly Ser Ser Arg Phe Ile Ile 
                165                 170                 175     


Ile Asn Ser Glu Ile Tyr Trp Pro Asn Gly Leu Thr Leu Asp Tyr Glu 
            180                 185                 190         


Glu Gln Lys Leu Tyr Trp Ala Asp Ala Lys Leu Asn Phe Ile His Lys 
        195                 200                 205             


Ser Asn Leu Asp Gly Thr Asn Arg Gln Ala Val Val Lys Gly Ser Leu 
    210                 215                 220                 


Pro His Pro Phe Ala Leu Thr Leu Phe Glu Asp Ile Leu Tyr Trp Thr 
225                 230                 235                 240 


Asp Trp Ser Thr His Ser Ile Leu Ala Cys Asn Lys Tyr Thr Gly Glu 
                245                 250                 255     


Gly Leu Arg Glu Ile His Ser Asp Ile Phe Ser Pro Met Asp Ile His 
            260                 265                 270         


Ala Phe Ser Gln Gln Arg Gln Pro Asn Ala Thr Asn Pro Cys Gly Ile 
        275                 280                 285             


Asp Asn Gly Gly Cys Ser His Leu Cys Leu Met Ser Pro Val Lys Pro 
    290                 295                 300                 


Phe Tyr Gln Cys Ala Cys Pro Thr Gly Val Lys Leu Leu Glu Asn Gly 
305                 310                 315                 320 


Lys Thr Cys Lys Asp Gly Ala Thr Glu Leu Leu Leu Leu Ala Arg Arg 
                325                 330                 335     


Thr Asp Leu Arg Arg Ile Ser Leu Asp Thr Pro Asp Phe Thr Asp Ile 
            340                 345                 350         


Val Leu Gln Leu Glu Asp Ile Arg His Ala Ile Ala Ile Asp Tyr Asp 
        355                 360                 365             


Pro Val Glu Gly Tyr Ile Tyr Trp Thr Asp Asp Glu Val Arg Ala Ile 
    370                 375                 380                 


Arg Arg Ser Phe Ile Asp Gly Ser Gly Ser Gln Phe Val Val Thr Ala 
385                 390                 395                 400 


Gln Ile Ala His Pro Asp Gly Ile Ala Val Asp Trp Val Ala Arg Asn 
                405                 410                 415     


Leu Tyr Trp Thr Asp Thr Gly Thr Asp Arg Ile Glu Val Thr Arg Leu 
            420                 425                 430         


Asn Gly Thr Met Arg Lys Ile Leu Ile Ser Glu Asp Leu Glu Glu Pro 
        435                 440                 445             


Arg Ala Ile Val Leu Asp Pro Met Val Gly Tyr Met Tyr Trp Thr Asp 
    450                 455                 460                 


Trp Gly Glu Ile Pro Lys Ile Glu Arg Ala Ala Leu Asp Gly Ser Asp 
465                 470                 475                 480 


Arg Val Val Leu Val Asn Thr Ser Leu Gly Trp Pro Asn Gly Leu Ala 
                485                 490                 495     


Leu Asp Tyr Asp Glu Gly Lys Ile Tyr Trp Gly Asp Ala Lys Thr Asp 
            500                 505                 510         


Lys Ile Glu Val Met Asn Thr Asp Gly Thr Gly Arg Arg Val Leu Val 
        515                 520                 525             


Glu Asp Lys Ile Pro His Ile Phe Gly Phe Thr Leu Leu Gly Asp Tyr 
    530                 535                 540                 


Val Tyr Trp Thr Asp Trp Gln Arg Arg Ser Ile Glu Arg Val His Lys 
545                 550                 555                 560 


Arg Ser Ala Glu Arg Glu Val Ile Ile Asp Gln Leu Pro Asp Leu Met 
                565                 570                 575     


Gly Leu Lys Ala Thr Asn Val His Arg Val Ile Gly Ser Asn Pro Cys 
            580                 585                 590         


Ala Glu Glu Asn Gly Gly Cys Ser His Leu Cys Leu Tyr Arg Pro Gln 
        595                 600                 605             


Gly Leu Arg Cys Ala Cys Pro Ile Gly Phe Glu Leu Ile Ser Asp Met 
    610                 615                 620                 


Lys Thr Cys Ile Val Pro Glu Ala Phe Leu Leu Phe Ser Arg Arg Ala 
625                 630                 635                 640 


Asp Ile Arg Arg Ile Ser Leu Glu Thr Asn Asn Asn Asn Val Ala Ile 
                645                 650                 655     


Pro Leu Thr Gly Val Lys Glu Ala Ser Ala Leu Asp Phe Asp Val Thr 
            660                 665                 670         


Asp Asn Arg Ile Tyr Trp Thr Asp Ile Ser Leu Lys Thr Ile Ser Arg 
        675                 680                 685             


Ala Phe Met Asn Gly Ser Ala Leu Glu His Val Val Glu Phe Gly Leu 
    690                 695                 700                 


Asp Tyr Pro Glu Gly Met Ala Val Asp Trp Leu Gly Lys Asn Leu Tyr 
705                 710                 715                 720 


Trp Ala Asp Thr Gly Thr Asn Arg Ile Glu Val Ser Lys Leu Asp Gly 
                725                 730                 735     


Gln His Arg Gln Val Leu Val Trp Lys Asp Leu Asp Ser Pro Arg Ala 
            740                 745                 750         


Leu Ala Leu Asp Pro Ala Glu Gly Phe Met Tyr Trp Thr Glu Trp Gly 
        755                 760                 765             


Gly Lys Pro Lys Ile Asp Arg Ala Ala Met Asp Gly Ser Glu Arg Thr 
    770                 775                 780                 


Thr Leu Val Pro Asn Val Gly Arg Ala Asn Gly Leu Thr Ile Asp Tyr 
785                 790                 795                 800 


Ala Lys Arg Arg Leu Tyr Trp Thr Asp Leu Asp Thr Asn Leu Ile Glu 
                805                 810                 815     


Ser Ser Asn Met Leu Gly Leu Asn Arg Glu Val Ile Ala Asp Asp Leu 
            820                 825                 830         


Pro His Pro Phe Gly Leu Thr Gln Tyr Gln Asp Tyr Ile Tyr Trp Thr 
        835                 840                 845             


Asp Trp Ser Arg Arg Ser Ile Glu Arg Ala Asn Lys Thr Ser Gly Gln 
    850                 855                 860                 


Asn Arg Thr Ile Ile Gln Gly His Leu Asp Tyr Val Met Asp Ile Leu 
865                 870                 875                 880 


Val Phe His Ser Ser Arg Gln Ser Gly Trp Asn Glu Cys Ala Ser Ser 
                885                 890                 895     


Asn Gly His Cys Ser His Leu Cys Leu Ala Val Pro Val Gly Gly Phe 
            900                 905                 910         


Val Cys Gly Cys Pro Ala His Tyr Ser Leu Asn Ala Asp Asn Arg Thr 
        915                 920                 925             


Cys Ser Ala Pro Thr Thr Phe Leu Leu Phe Ser Gln Lys Ser Ala Ile 
    930                 935                 940                 


Asn Arg Met Val Ile Asp Glu Gln Gln Ser Pro Asp Ile Ile Leu Pro 
945                 950                 955                 960 


Ile His Ser Leu Arg Asn Val Arg Ala Ile Asp Tyr Asp Pro Leu Asp 
                965                 970                 975     


Lys Gln Leu Tyr Trp Ile Asp Ser Arg Gln Asn Met Ile Arg Lys Ala 
            980                 985                 990         


Gln Glu Asp Gly Ser Gln Gly Phe  Thr Val Val Val Ser  Ser Val Pro 
        995                 1000                 1005             


Ser Gln  Asn Leu Glu Ile Gln  Pro Tyr Asp Leu Ser  Ile Asp Ile 
    1010                 1015                 1020             


Tyr Ser  Arg Tyr Ile Tyr Trp  Thr Cys Glu Ala Thr  Asn Val Ile 
    1025                 1030                 1035             


Asn Val  Thr Arg Leu Asp Gly  Arg Ser Val Gly Val  Val Leu Lys 
    1040                 1045                 1050             


Gly Glu  Gln Asp Arg Pro Arg  Ala Val Val Val Asn  Pro Glu Lys 
    1055                 1060                 1065             


Gly Tyr  Met Tyr Phe Thr Asn  Leu Gln Glu Arg Ser  Pro Lys Ile 
    1070                 1075                 1080             


Glu Arg  Ala Ala Leu Asp Gly  Thr Glu Arg Glu Val  Leu Phe Phe 
    1085                 1090                 1095             


Ser Gly  Leu Ser Lys Pro Ile  Ala Leu Ala Leu Asp  Ser Arg Leu 
    1100                 1105                 1110             


Gly Lys  Leu Phe Trp Ala Asp  Ser Asp Leu Arg Arg  Ile Glu Ser 
    1115                 1120                 1125             


Ser Asp  Leu Ser Gly Ala Asn  Arg Ile Val Leu Glu  Asp Ser Asn 
    1130                 1135                 1140             


Ile Leu  Gln Pro Val Gly Leu  Thr Val Phe Glu Asn  Trp Leu Tyr 
    1145                 1150                 1155             


Trp Ile  Asp Lys Gln Gln Gln  Met Ile Glu Lys Ile  Asp Met Thr 
    1160                 1165                 1170             


Gly Arg  Glu Gly Arg Thr Lys  Val Gln Ala Arg Ile  Ala Gln Leu 
    1175                 1180                 1185             


Ser Asp  Ile His Ala Val Lys  Glu Leu Asn Leu Gln  Glu Tyr Arg 
    1190                 1195                 1200             


Gln His  Pro Cys Ala Gln Asp  Asn Gly Gly Cys Ser  His Ile Cys 
    1205                 1210                 1215             


Leu Val  Lys Gly Asp Gly Thr  Thr Arg Cys Ser Cys  Pro Met His 
    1220                 1225                 1230             


Leu Val  Leu Leu Gln Asp Glu  Leu Ser Cys Gly Glu  Pro Pro Thr 
    1235                 1240                 1245             


Cys Ser  Pro Gln Gln Phe Thr  Cys Phe Thr Gly Glu  Ile Asp Cys 
    1250                 1255                 1260             


Ile Pro  Val Ala Trp Arg Cys  Asp Gly Phe Thr Glu  Cys Glu Asp 
    1265                 1270                 1275             


His Ser  Asp Glu Leu Asn Cys  Pro Val Cys Ser Glu  Ser Gln Phe 
    1280                 1285                 1290             


Gln Cys  Ala Ser Gly Gln Cys  Ile Asp Gly Ala Leu  Arg Cys Asn 
    1295                 1300                 1305             


Gly Asp  Ala Asn Cys Gln Asp  Lys Ser Asp Glu Lys  Asn Cys Glu 
    1310                 1315                 1320             


Val Leu  Cys Leu Ile Asp Gln  Phe Arg Cys Ala Asn  Gly Gln Cys 
    1325                 1330                 1335             


Ile Gly  Lys His Lys Lys Cys  Asp His Asn Val Asp  Cys Ser Asp 
    1340                 1345                 1350             


Lys Ser  Asp Glu Leu Asp Cys  Tyr Pro Thr Glu Glu  Pro Ala Pro 
    1355                 1360                 1365             


Gln Ala  Thr Asn Thr Val Gly  Ser Val Ile Gly Val  Ile Val Thr 
    1370                 1375                 1380             


Ile Phe  Val Ser Gly Thr Val  Tyr Phe Ile Cys Gln  Arg Met Leu 
    1385                 1390                 1395             


Cys Pro  Arg Met Lys Gly Asp  Gly Glu Thr Met Thr  Asn Asp Tyr 
    1400                 1405                 1410             


Val Val  His Gly Pro Ala Ser  Val Pro Leu Gly Tyr  Val Pro His 
    1415                 1420                 1425             


Pro Ser  Ser Leu Ser Gly Ser  Leu Pro Gly Met Ser  Arg Gly Lys 
    1430                 1435                 1440             


Ser Met  Ile Ser Ser Leu Ser  Ile Met Gly Gly Ser  Ser Gly Pro 
    1445                 1450                 1455             


Pro Tyr  Asp Arg Ala His Val  Thr Gly Ala Ser Ser  Ser Ser Ser 
    1460                 1465                 1470             


Ser Ser  Thr Lys Gly Thr Tyr  Phe Pro Ala Ile Leu  Asn Pro Pro 
    1475                 1480                 1485             


Pro Ser  Pro Ala Thr Glu Arg  Ser His Tyr Thr Met  Glu Phe Gly 
    1490                 1495                 1500             


Tyr Ser  Ser Asn Ser Pro Ser  Thr His Arg Ser Tyr  Ser Tyr Arg 
    1505                 1510                 1515             


Pro Tyr  Ser Tyr Arg His Phe  Ala Pro Pro Thr Thr  Pro Cys Ser 
    1520                 1525                 1530             


Thr Asp  Val Cys Asp Ser Asp  Tyr Ala Pro Ser Arg  Arg Met Thr 
    1535                 1540                 1545             


Ser Val  Ala Thr Ala Lys Gly  Tyr Thr Ser Asp Leu  Asn Tyr Asp 
    1550                 1555                 1560             


Ser Glu  Pro Val Pro Pro Pro  Pro Thr Pro Arg Ser  Gln Tyr Leu 
    1565                 1570                 1575             


Ser Ala  Glu Glu Asn Tyr Glu  Ser Cys Pro Pro Ser  Pro Tyr Thr 
    1580                 1585                 1590             


Glu Arg  Ser Tyr Ser His His  Leu Tyr Pro Pro Pro  Pro Ser Pro 
    1595                 1600                 1605             


Cys Thr  Asp Ser Ser 
    1610             


<210>  80
<211>  4842
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  80
atgggggccg tcctgaggag cctcctggcc tgcagcttct gtgtgctcct gagagcggcc       60

cctttgttgc tttatgcaaa cagacgggac ttgcgattgg ttgatgctac aaatggcaaa      120

gagaatgcta cgattgtagt tggaggcttg gaggatgcag ctgcggtgga ctttgtgttt      180

agtcatggct tgatatactg gagtgatgtc agcgaagaag ccattaaacg aacagaattt      240

aacaaaactg agagtgtgca gaatgttgtt gtttctggat tattgtcccc cgatgggctg      300

gcatgtgatt ggcttggaga aaaattgtac tggacagatt ctgaaactaa tcggattgaa      360

gtttctaatt tagatggatc tttacgaaaa gttttatttt ggcaagagtt ggatcaaccc      420

agagctattg ccttagatcc ttcaagtggg ttcatgtact ggacagactg gggagaagtg      480

ccaaagatag aacgtgctgg aatggatggt tcaagtcgct tcattataat aaacagtgaa      540

atttactggc caaatggact gactttggat tatgaagaac aaaagcttta ttgggcagat      600

gcaaaactta atttcatcca caaatcaaat ctggatggaa caaatcggca ggcagtggtt      660

aaaggttccc ttccacatcc ttttgccttg acgttatttg aggacatatt gtactggact      720

gactggagca cacactccat tttggcttgc aacaagtata ctggtgaggg tctgcgtgaa      780

atccattctg acatcttctc tcccatggat atacatgcct tcagccaaca gaggcagcca      840

aatgccacaa atccatgtgg aattgacaat gggggttgtt cccatttgtg tttgatgtct      900

ccagtcaagc ctttttatca gtgtgcttgc cccactgggg tcaaactcct ggagaatgga      960

aaaacctgca aagatggtgc cacagaatta ttgcttttag ctcgaaggac agacttgaga     1020

cgcatttctt tggatacacc agattttaca gacattgttc tgcagttaga agacatccgt     1080

catgccattg ccatagatta cgatcctgtg gaaggctaca tctactggac tgatgatgaa     1140

gtgagggcca tacgccgttc atttatagat ggatctggca gtcagtttgt ggtcactgct     1200

caaattgccc atcctgatgg tattgctgtg gactgggttg cacgaaatct ttattggaca     1260

gacactggca ctgatcgaat agaagtgaca aggctcaatg ggaccatgag gaagatcttg     1320

atttcagagg acttagagga accccgggct attgtgttag atcccatggt tgggtacatg     1380

tattggactg actggggaga aattccgaaa attgagcgag cagctctgga tggttctgac     1440

cgtgtagtat tggttaacac ttctcttggt tggccaaatg gtttagcctt ggattatgat     1500

gaaggcaaaa tatactgggg agatgccaaa acagacaaga ttgaggttat gaatactgat     1560

ggcactggga gacgagtact agtggaagac aaaattcctc acatatttgg atttactttg     1620

ttgggtgact atgtttactg gactgactgg cagaggcgta gcattgaaag agttcataaa     1680

cgaagtgcag agagggaagt gatcatagat cagctgcctg acctcatggg cctaaaggct     1740

acaaatgttc atcgagtgat tggttccaac ccctgtgctg aggaaaacgg gggatgtagc     1800

catctctgcc tctatagacc tcagggcctt cgctgtgctt gccctattgg ctttgaactc     1860

atcagtgaca tgaagacctg cattgtccca gaggctttcc ttttgttttc acggagagca     1920

gatatcagac gaatttctct ggaaacaaac aataataatg tggctattcc actcactggt     1980

gtcaaagaag cttctgcttt ggattttgat gtgacagaca accgaattta ttggactgat     2040

atatcactca agaccatcag cagagccttt atgaatggca gtgcactgga acatgtggta     2100

gaattcggct tagattatcc agaaggcatg gcagtagact ggcttgggaa gaacttgtac     2160

tgggcagaca caggaacgaa tcgaattgag gtgtcaaagt tggatgggca gcaccgacaa     2220

gttttggtgt ggaaagacct agatagtccc agagctctcg cgttggaccc tgccgaagga     2280

tttatgtatt ggactgaatg gggtggaaaa cctaagatag acagagctgc aatggatgga     2340

agtgaacgta ctaccttagt tccaaatgtg gggcgggcaa acggcctaac tattgattat     2400

gctaaaagga ggctttattg gacagacctg gacaccaact taatagaatc ttcaaatatg     2460

cttgggctca accgtgaagt tatagcagat gacttgcctc atccttttgg cttaactcag     2520

taccaagatt atatctactg gacggactgg agccgacgca gcattgagcg tgccaacaaa     2580

accagtggcc aaaaccgcac catcattcag ggccatttgg attatgtgat ggacatcctc     2640

gtctttcact catctcgaca gtcagggtgg aatgaatgtg cttccagcaa tgggcactgc     2700

tcccacctct gcttggctgt gccagttggg ggttttgttt gtggatgccc tgcccactac     2760

tctcttaatg ctgacaacag gacttgtagt gctcctacga ctttcctgct cttcagtcaa     2820

aagagtgcca tcaaccgcat ggtgattgat gaacaacaga gccccgacat catccttccc     2880

atccacagcc ttcggaatgt ccgggccatt gactatgacc cactggacaa gcaactctat     2940

tggattgact cacgacaaaa catgatccga aaggcacaag aagatggcag ccagggcttt     3000

actgtggttg tgagctcagt tccgagtcag aacctggaaa tacaacccta tgacctcagc     3060

attgatattt acagccgcta catctactgg acttgtgagg ctaccaatgt cattaatgtg     3120

acaagattag atgggagatc agttggagtg gtgctgaaag gcgagcagga cagacctcga     3180

gccgttgtgg taaacccaga gaaagggtat atgtatttta ccaatcttca ggaaaggtct     3240

cctaaaattg aacgggctgc tttggatggg acagaacggg aggtcctctt tttcagtggc     3300

ttaagtaaac caattgcttt agcccttgat agcaggctgg gcaagctctt ttgggctgat     3360

tcagatctcc ggcgaattga aagcagtgat ctctcaggtg ctaaccggat agtattagaa     3420

gactccaata tcttgcagcc tgtgggactt actgtgtttg aaaactggct ctattggatt     3480

gataaacagc agcaaatgat tgaaaaaatt gacatgacag gtcgagaggg tagaaccaaa     3540

gtccaagctc gaattgccca gcttagtgac attcatgcag taaaggagct gaaccttcaa     3600

gaatacagac agcacccttg tgctcaggat aatggtggct gttcacatat ttgtcttgta     3660

aagggggatg gtactacaag gtgttcttgc cccatgcacc tggttctact tcaagatgag     3720

ctatcatgtg gagaacctcc aacatgttct cctcagcagt ttacttgttt cacgggggaa     3780

attgactgta tccctgtggc ttggcggtgc gatgggttta ctgaatgtga agaccacagt     3840

gatgaactca attgtcctgt atgctcagag tcccagttcc agtgtgccag tgggcagtgt     3900

attgatggtg ccctccgatg caatggagat gcaaactgcc aggacaaatc agatgagaag     3960

aactgtgaag tgctttgttt aattgatcag ttccgctgtg ccaatggtca gtgcattgga     4020

aagcacaaga agtgtgatca taatgtggat tgcagtgaca agtcagatga actggattgt     4080

tatccgactg aagaaccagc accacaggcc accaatacag ttggttctgt tattggcgta     4140

attgtcacca tttttgtgtc tggaactgta tactttatct gccagaggat gttgtgtcca     4200

cgtatgaagg gagatgggga aactatgact aatgactatg tagttcatgg accagcttct     4260

gtgcctcttg gttatgtgcc acacccaagt tctttgtcag gatctcttcc aggaatgtct     4320

cgaggtaaat caatgatcag ctccctcagt atcatggggg gaagcagtgg acccccctat     4380

gaccgagccc atgttacagg agcatcatca agtagttctt caagcaccaa aggcacttac     4440

ttccctgcaa ttttgaaccc tccaccatcc ccagccacag agcgatcaca ttacactatg     4500

gaatttggat attcttcaaa cagtccttcc actcataggt catacagcta caggccatat     4560

agctaccggc actttgcacc ccccaccaca ccctgcagca cagatgtttg tgacagtgac     4620

tatgctccta gtcggagaat gacctcagtg gcaacagcca agggctatac cagtgacttg     4680

aactatgatt cagaacctgt gcccccacct cccacacccc gaagccaata cttgtcagca     4740

gaggagaact atgaaagctg cccaccttct ccatacacag agaggagcta ttctcatcac     4800

ctctacccac cgccaccctc tccctgtaca gactcctcct ga                        4842


<210>  81
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  81

Ser Pro Lys Lys Lys Arg Lys Val Glu Ala Ser 
1               5                   10      


<210>  82
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  82

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  83
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  83

Lys Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 
1               5                   10                  15      


Ser 
    


<210>  84
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Asp Leu Trp Gln Leu Leu Leu Thr Leu Ala Leu Ala Gly Ser Ser 
1               5                   10                  15      


Asp Ala Phe Ser Gly Ser Glu Ala Thr Ala Ala Ile Leu Ser Arg Ala 
            20                  25                  30          


Pro Trp Ser Leu Gln Ser Val Asn Pro Gly Leu Lys Thr Asn Ser Ser 
        35                  40                  45              


Lys Glu Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe 
    50                  55                  60                  


Ser Cys His Trp Thr Asp Glu Val His His Gly Thr Lys Asn Leu Gly 
65                  70                  75                  80  


Pro Ile Gln Leu Phe Tyr Thr Arg Arg Asn Thr Gln Glu Trp Thr Gln 
                85                  90                  95      


Glu Trp Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys 
            100                 105                 110         


Tyr Phe Asn Ser Ser Phe Thr Ser Ile Trp Ile Pro Tyr Cys Ile Lys 
        115                 120                 125             


Leu Thr Ser Asn Gly Gly Thr Val Asp Glu Lys Cys Phe Ser Val Asp 
    130                 135                 140                 


Glu Ile Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu 
145                 150                 155                 160 


Asn Val Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu 
                165                 170                 175     


Ala Pro Arg Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr 
            180                 185                 190         


Glu Leu Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp 
        195                 200                 205             


Pro Ile Leu Thr Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys 
    210                 215                 220                 


Glu Tyr Glu Val Arg Val Arg Ser Lys Gln Arg Asn Ser Gly Asn Tyr 
225                 230                 235                 240 


Gly Glu Phe Ser Glu Val Leu Tyr Val Thr Leu Pro Gln Met Ser Gln 
                245                 250                 255     


Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile Ile Ile 
            260                 265                 270         


Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe Ser 
        275                 280                 285             


Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro 
    290                 295                 300                 


Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu 
305                 310                 315                 320 


Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe 
                325                 330                 335     


His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu 
            340                 345                 350         


Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser 
        355                 360                 365             


Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
    370                 375                 380                 


Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
385                 390                 395                 400 


Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
                405                 410                 415     


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
            420                 425                 430         


Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
        435                 440                 445             


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala 
    450                 455                 460                 


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
465                 470                 475                 480 


Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
                485                 490                 495     


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
            500                 505                 510         


Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe 
        515                 520                 525             


Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile 
    530                 535                 540                 


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu 
545                 550                 555                 560 


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala 
                565                 570                 575     


Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val 
            580                 585                 590         


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
        595                 600                 605             


Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser 
    610                 615                 620                 


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
625                 630                 635             


<210>  85
<211>  1917
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  85
atggatctct ggcagctgct gttgaccttg gcactggcag gatcaagtga tgctttttct       60

ggaagtgagg ccacagcagc tatccttagc agagcaccct ggagtctgca aagtgttaat      120

ccaggcctaa agacaaattc ttctaaggag cctaaattca ccaagtgccg ttcacctgag      180

cgagagactt tttcatgcca ctggacagat gaggttcatc atggtacaaa gaacctagga      240

cccatacagc tgttctatac cagaaggaac actcaagaat ggactcaaga atggaaagaa      300

tgccctgatt atgtttctgc tggggaaaac agctgttact ttaattcatc gtttacctcc      360

atctggatac cttattgtat caagctaact agcaatggtg gtacagtgga tgaaaagtgt      420

ttctctgttg atgaaatagt gcaaccagat ccacccattg ccctcaactg gactttactg      480

aacgtcagtt taactgggat tcatgcagat atccaagtga gatgggaagc accacgcaat      540

gcagatattc agaaaggatg gatggttctg gagtatgaac ttcaatacaa agaagtaaat      600

gaaactaaat ggaaaatgat ggaccctata ttgacaacat cagttccagt gtactcattg      660

aaagtggata aggaatatga agtgcgtgtg agatccaaac aacgaaactc tggaaattat      720

ggcgagttca gtgaggtgct ctatgtaaca cttcctcaga tgagccaatt tacatgtgaa      780

gaagatttct actttccatg gctcttaatt attatctttg gaatatttgg gctaacagtg      840

atgctatttg tattcttatt ttctaaacag caaaggatta aaatgctgat tctgccccca      900

gttccagttc caaagattaa aggaatcgat ccagatctcc tcaaggaagg aaaattagag      960

gaggtgaaca caatcttagc cattcatgat agctataaac ccgaattcca cagtgatgac     1020

tcttgggttg aatttattga gctagatatt gatgagccag atgaaaagac tgaggaatca     1080

gacacagaca gacttctaag cagtgaccat gagaaatcac atagtaacct aggggtgaag     1140

gatggcgact ctggacgtac cagctgttgt gaacctgaca ttctggagac tgatttcaat     1200

gccaatgaca tacatgaggg tacctcagag gttgctcagc cacagaggtt aaaaggggaa     1260

gcagatctct tatgccttga ccagaagaat caaaataact caccttatca tgatgcttgc     1320

cctgctactc agcagcccag tgttatccaa gcagagaaaa acaaaccaca accacttcct     1380

actgaaggag ctgagtcaac tcaccaagct gcccatattc agctaagcaa tccaagttca     1440

ctgtcaaaca tcgactttta tgcccaggtg agcgacatta caccagcagg tagtgtggtc     1500

ctttccccgg gccaaaagaa taaggcaggg atgtcccaat gtgacatgca cccggaaatg     1560

gtctcactct gccaagaaaa cttccttatg gacaatgcct acttctgtga ggcagatgcc     1620

aaaaagtgca tccctgtggc tcctcacatc aaggttgaat cacacataca gccaagctta     1680

aaccaagagg acatttacat caccacagaa agccttacca ctgctgctgg gaggcctggg     1740

acaggagaac atgttccagg ttctgagatg cctgtcccag actatacctc cattcatata     1800

gtacagtccc cacagggcct catactcaat gcgactgcct tgcccttgcc tgacaaagag     1860

tttctctcat catgtggcta tgtgagcaca gaccaactga acaaaatcat gccttag        1917


<210>  86
<211>  288
<212>  PRT
<213>  homo sapiens

<400>  86

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  87
<211>  867
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cDNA

<400>  87
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atctgctccc gggccgcacg agggacaata      600

ggagccaggc gcaccggcca gcccctgaag gaggacccct cagccgtgcc tgtgttctct      660

gtggactatg gggagctgga tttccagtgg cgagagaaga ccccggagcc ccccgtgccc      720

tgtgtccctg agcagacgga gtatgccacc attgtctttc ctagcggaat gggcacctca      780

tcccccgccc gcaggggctc agctgacggc cctcggagtg cccagccact gaggcctgag      840

gatggacact gctcttggcc cctctga                                          867


<210>  88
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  89
<211>  873
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cDNA

<400>  89
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggactcac      720

ttggtaattc tgggagccat cttattatgc cttggtgtag cactgacatt catcttccgt      780

ttaagaaaag ggagaatgat ggatgtgaaa aaatgtggca tccaagatac aaactcaaag      840

aagcaaagtg atacacattt ggaggagacg taa                                   873


<210>  90
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  91
<211>  672
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cDNA

<400>  91
atggcttgcc ttggatttca gcggcacaag gctcagctga acctggctac caggacctgg       60

ccctgcactc tcctgttttt tcttctcttc atccctgtct tctgcaaagc aatgcacgtg      120

gcccagcctg ctgtggtact ggccagcagc cgaggcatcg ccagctttgt gtgtgagtat      180

gcatctccag gcaaagccac tgaggtccgg gtgacagtgc ttcggcaggc tgacagccag      240

gtgactgaag tctgtgcggc aacctacatg atggggaatg agttgacctt cctagatgat      300

tccatctgca cgggcacctc cagtggaaat caagtgaacc tcactatcca aggactgagg      360

gccatggaca cgggactcta catctgcaag gtggagctca tgtacccacc gccatactac      420

ctgggcatag gcaacggaac ccagatttat gtaattgatc cagaaccgtg cccagattct      480

gacttcctcc tctggatcct tgcagcagtt agttcggggt tgttttttta tagctttctc      540

ctcacagctg tttctttgag caaaatgcta aagaaaagaa gccctcttac aacaggggtc      600

tatgtgaaaa tgcccccaac agagccagaa tgtgaaaagc aatttcagcc ttattttatt      660

cccatcaatt ga                                                          672


<210>  92
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Glu Asn Gly Ala Val Tyr Ser Pro Thr Thr Glu Glu Asp Pro Gly 
1               5                   10                  15      


Pro Ala Arg Gly Pro Arg Ser Gly Leu Ala Ala Tyr Phe Phe Met Gly 
            20                  25                  30          


Arg Leu Pro Leu Leu Arg Arg Val Leu Lys Gly Leu Gln Leu Leu Leu 
        35                  40                  45              


Ser Leu Leu Ala Phe Ile Cys Glu Glu Val Val Ser Gln Cys Thr Leu 
    50                  55                  60                  


Cys Gly Gly Leu Tyr Phe Phe Glu Phe Val Ser Cys Ser Ala Phe Leu 
65                  70                  75                  80  


Leu Ser Leu Leu Ile Leu Ile Val Tyr Cys Thr Pro Phe Tyr Glu Arg 
                85                  90                  95      


Val Asp Thr Thr Lys Val Lys Ser Ser Asp Phe Tyr Ile Thr Leu Gly 
            100                 105                 110         


Thr Gly Cys Val Phe Leu Leu Ala Ser Ile Ile Phe Val Ser Thr His 
        115                 120                 125             


Asp Arg Thr Ser Ala Glu Ile Ala Ala Ile Val Phe Gly Phe Ile Ala 
    130                 135                 140                 


Ser Phe Met Phe Leu Leu Asp Phe Ile Thr Met Leu Tyr Glu Lys Arg 
145                 150                 155                 160 


Gln Glu Ser Gln Leu Arg Lys Pro Glu Asn Thr Thr Arg Ala Glu Ala 
                165                 170                 175     


Leu Thr Glu Pro Leu Asn Ala 
            180             


<210>  93
<211>  552
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cDNA

<400>  93
atggagaacg gagcggtgta cagccccact acggaggagg acccgggccc cgccagaggc       60

ccccggagcg gcctcgctgc ctactttttc atgggccggc tcccattgct ccggcgcgtt      120

ctcaagggct tgcagctgtt gctgtctctg ctggccttca tctgtgaaga agttgtatca      180

caatgtactt tatgtggagg actttatttt tttgagtttg taagctgcag tgcctttctt      240

ctgagtctcc ttatactgat tgtgtattgc actccatttt atgagagagt tgataccaca      300

aaagtaaaat catcggattt ttatattact ttgggaacag gatgtgtgtt tttgttggca      360

tccatcattt ttgtttccac acatgacagg acttcagctg agattgctgc aattgtgttt      420

ggatttatag caagttttat gttcctactt gactttatca ctatgctgta tgaaaaacga      480

caggagtccc agctgagaaa acctgaaaat accactaggg ctgaagccct cactgagcca      540

cttaatgcct aa                                                          552


<210>  94
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Arg Ser Gly Glu Glu Leu Asp Gly Phe Glu Gly Glu Ala Ser Ser 
1               5                   10                  15      


Thr Ser Met Ile Ser Gly Ala Ser Ser Pro Tyr Gln Pro Thr Thr Glu 
            20                  25                  30          


Pro Val Ser Gln Arg Arg Gly Leu Ala Gly Leu Arg Cys Asp Pro Asp 
        35                  40                  45              


Tyr Leu Arg Gly Ala Leu Gly Arg Leu Lys Val Ala Gln Val Ile Leu 
    50                  55                  60                  


Ala Leu Ile Ala Phe Ile Cys Ile Glu Thr Ile Met Ala Cys Ser Pro 
65                  70                  75                  80  


Cys Glu Gly Leu Tyr Phe Phe Glu Phe Val Ser Cys Ser Ala Phe Val 
                85                  90                  95      


Val Thr Gly Val Leu Leu Ile Met Phe Ser Leu Asn Leu His Met Arg 
            100                 105                 110         


Ile Pro Gln Ile Asn Trp Asn Leu Thr Asp Leu Val Asn Thr Gly Leu 
        115                 120                 125             


Ser Ala Phe Leu Phe Phe Ile Ala Ser Ile Val Leu Ala Ala Leu Asn 
    130                 135                 140                 


His Arg Ala Gly Ala Glu Ile Ala Ala Val Ile Phe Gly Phe Leu Ala 
145                 150                 155                 160 


Thr Ala Ala Tyr Ala Val Asn Thr Phe Leu Ala Val Gln Lys Trp Arg 
                165                 170                 175     


Val Ser Val Arg Gln Gln Ser Thr Asn Asp Tyr Ile Arg Ala Arg Thr 
            180                 185                 190         


Glu Ser Arg Asp Val Asp Ser Arg Pro Glu Ile Gln Arg Leu Asp Thr 
        195                 200                 205             


Phe Ser Tyr Ser Thr Asn Val Thr Val Arg Lys Lys Ser Pro Thr Asn 
    210                 215                 220                 


Leu Leu Ser Leu Asn His Trp Gln Leu Ala 
225                 230                 


<210>  95
<211>  627
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cDNA

<400>  95
atgcggagcg gcgaggagct ggacggcttc gagggcgagg cctcgagcac ctccatgatc       60

tcgggcgcca gcagcccgta ccagcccacc accgagccgg tgagccagcg ccgcgggctg      120

gccggcctgc gctgcgaccc cgactacctg cgcggcgcgc tcggccgcct caaggtcgcc      180

caagtgatct tggccctgat tgcattcatc tgcatagaga ccatcatggc atgctccccg      240

tgtgaaggcc tctacttttt tgagtttgtg agctgcagtg cgtttgtggt gactggcgtc      300

ttgctgatta tgttcagtct caacctgcac atgaggatcc cccagatcaa ctggaatctg      360

acagatttgg tcaacactgg actcagcgct ttccttttct ttattgcttc aatcgtactg      420

gctgctttaa accatagagc cggagcagaa attgctgccg tgatatttgg cttcttggcg      480

actgcggcat atgcagtgaa cacattcctg gcagtgcaga aatggagagt cagcgtccgc      540

cagcagagca ccaatgacta catccgagcc cgcacggagt ccagggatgt ggacagtcgc      600

cctgagatcc agcgcctgga cacgtga                                          627


<210>  96
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  alpha tag

<400>  96

Met Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu Pro 
1               5                   10                  15      


<210>  97
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E6 tag

<400>  97

Gln Ala Asp Gln Glu Ala Lys Glu Leu Ala Arg Gln Ile Ser 
1               5                   10                  


<210>  98
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-alpha VHH

<400>  98

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Val Thr Ile Ser Ala Leu 
            20                  25                  30          


Asn Ala Met Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Glu Arg Arg 
        35                  40                  45              


Val Met Val Ala Ala Val Ser Glu Arg Gly Asn Ala Met Tyr Arg Glu 
    50                  55                  60                  


Ser Val Gln Gly Arg Phe Thr Val Thr Arg Asp Phe Thr Asn Lys Met 
65                  70                  75                  80  


Val Ser Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys His Val Leu Glu Asp Arg Val Asp Ser Phe His Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  99
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3 anti-E6 VHH

<400>  99

Val Tyr Tyr Cys Ser Lys Ser Gly Ala Tyr Trp Gly Gln Gly Thr Gln 
1               5                   10                  15      


Val Thr 
        


<210>  100
<211>  541
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ala Gly Ala Ile Ile Glu Asn Met Ser Thr Lys Lys Leu Cys Ile 
1               5                   10                  15      


Val Gly Gly Ile Leu Leu Val Phe Gln Ile Ile Ala Phe Leu Val Gly 
            20                  25                  30          


Gly Leu Ile Ala Pro Gly Pro Thr Thr Ala Val Ser Tyr Met Ser Val 
        35                  40                  45              


Lys Cys Val Asp Ala Arg Lys Asn His His Lys Thr Lys Trp Phe Val 
    50                  55                  60                  


Pro Trp Gly Pro Asn His Cys Asp Lys Ile Arg Asp Ile Glu Glu Ala 
65                  70                  75                  80  


Ile Pro Arg Glu Ile Glu Ala Asn Asp Ile Val Phe Ser Val His Ile 
                85                  90                  95      


Pro Leu Pro His Met Glu Met Ser Pro Trp Phe Gln Phe Met Leu Phe 
            100                 105                 110         


Ile Leu Gln Leu Asp Ile Ala Phe Lys Leu Asn Asn Gln Ile Arg Glu 
        115                 120                 125             


Asn Ala Glu Val Ser Met Asp Val Ser Leu Ala Tyr Arg Asp Asp Ala 
    130                 135                 140                 


Phe Ala Glu Trp Thr Glu Met Ala His Glu Arg Val Pro Arg Lys Leu 
145                 150                 155                 160 


Lys Cys Thr Phe Thr Ser Pro Lys Thr Pro Glu His Glu Gly Arg Tyr 
                165                 170                 175     


Tyr Glu Cys Asp Val Leu Pro Phe Met Glu Ile Gly Ser Val Ala His 
            180                 185                 190         


Lys Phe Tyr Leu Leu Asn Ile Arg Leu Pro Val Asn Glu Lys Lys Lys 
        195                 200                 205             


Ile Asn Val Gly Ile Gly Glu Ile Lys Asp Ile Arg Leu Val Gly Ile 
    210                 215                 220                 


His Gln Asn Gly Gly Phe Thr Lys Val Trp Phe Ala Met Lys Thr Phe 
225                 230                 235                 240 


Leu Thr Pro Ser Ile Phe Ile Ile Met Val Trp Tyr Trp Arg Arg Ile 
                245                 250                 255     


Thr Met Met Ser Arg Pro Pro Val Leu Leu Glu Lys Val Ile Phe Ala 
            260                 265                 270         


Leu Gly Ile Ser Met Thr Phe Ile Asn Ile Pro Val Glu Trp Phe Ser 
        275                 280                 285             


Ile Gly Phe Asp Trp Thr Trp Met Leu Leu Phe Gly Asp Ile Arg Gln 
    290                 295                 300                 


Gly Ile Phe Tyr Ala Met Leu Leu Ser Phe Trp Ile Ile Phe Cys Gly 
305                 310                 315                 320 


Glu His Met Met Asp Gln His Glu Arg Asn His Ile Ala Gly Tyr Trp 
                325                 330                 335     


Lys Gln Val Gly Pro Ile Ala Val Gly Ser Phe Cys Leu Phe Ile Phe 
            340                 345                 350         


Asp Met Cys Glu Arg Gly Val Gln Leu Thr Asn Pro Phe Tyr Ser Ile 
        355                 360                 365             


Trp Thr Thr Asp Ile Gly Thr Glu Leu Ala Met Ala Phe Ile Ile Val 
    370                 375                 380                 


Ala Gly Ile Cys Leu Cys Leu Tyr Phe Leu Phe Leu Cys Phe Met Val 
385                 390                 395                 400 


Phe Gln Val Phe Arg Asn Ile Ser Gly Lys Gln Ser Ser Leu Pro Ala 
                405                 410                 415     


Met Ser Lys Val Arg Arg Leu His Tyr Glu Gly Leu Ile Phe Arg Phe 
            420                 425                 430         


Lys Phe Leu Met Leu Ile Thr Leu Ala Cys Ala Ala Met Thr Val Ile 
        435                 440                 445             


Phe Phe Ile Val Ser Gln Val Thr Glu Gly His Trp Lys Trp Gly Gly 
    450                 455                 460                 


Val Thr Val Gln Val Asn Ser Ala Phe Phe Thr Gly Ile Tyr Gly Met 
465                 470                 475                 480 


Trp Asn Leu Tyr Val Phe Ala Leu Met Phe Leu Tyr Ala Pro Ser His 
                485                 490                 495     


Lys Asn Tyr Gly Glu Asp Gln Ser Asn Gly Asp Leu Gly Val His Ser 
            500                 505                 510         


Gly Glu Glu Leu Gln Leu Thr Thr Thr Ile Thr His Val Asp Gly Pro 
        515                 520                 525             


Thr Glu Ile Tyr Lys Leu Thr Arg Lys Glu Ala Gln Glu 
    530                 535                 540     


<210>  101
<211>  1626
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cDNA

<400>  101
atggctgggg caattataga aaacatgagc accaagaagc tgtgcattgt tggtgggatt       60

ctgctcgtgt tccaaatcat cgcctttctg gtgggaggct tgattgctcc agggcccaca      120

acggcagtgt cctacatgtc ggtgaaatgt gtggatgccc gtaagaacca tcacaagaca      180

aaatggttcg tgccttgggg acccaatcat tgtgacaaga tccgagacat tgaagaggca      240

attccaaggg aaattgaagc caatgacatc gtgttttctg ttcacattcc cctcccccac      300

atggagatga gtccttggtt ccaattcatg ctgtttatcc tgcagctgga cattgccttc      360

aagctaaaca accaaatcag agaaaatgca gaagtctcca tggacgtttc cctggcttac      420

cgtgatgacg cgtttgctga gtggactgaa atggcccatg aaagagtacc acggaaactc      480

aaatgcacct tcacatctcc caagactcca gagcatgagg gccgttacta tgaatgtgat      540

gtccttcctt tcatggaaat tgggtctgtg gcccataagt tttacctttt aaacatccgg      600

ctgcctgtga atgagaagaa gaaaatcaat gtgggaattg gggagataaa ggatatccgg      660

ttggtgggga tccaccaaaa tggaggcttc accaaggtgt ggtttgccat gaagaccttc      720

cttacgccca gcatcttcat cattatggtg tggtattgga ggaggatcac catgatgtcc      780

cgacccccag tgcttctgga aaaagtcatc tttgcccttg ggatttccat gacctttatc      840

aatatcccag tggaatggtt ttccatcggg tttgactgga cctggatgct gctgtttggt      900

gacatccgac agggcatctt ctatgcgatg cttctgtcct tctggatcat cttctgtggc      960

gagcacatga tggatcagca cgagcggaac cacatcgcag ggtattggaa gcaagtcgga     1020

cccattgccg ttggctcctt ctgcctcttc atatttgaca tgtgtgagag aggggtacaa     1080

ctcacgaatc ccttctacag tatctggact acagacattg gaacagagct ggccatggcc     1140

ttcatcatcg tggctggaat ctgcctctgc ctctacttcc tgtttctatg cttcatggta     1200

tttcaggtgt ttcggaacat cagtgggaag cagtccagcc tgccagctat gagcaaagtc     1260

cggcggctac actatgaggg gctaattttt aggttcaagt tcctcatgct tatcaccttg     1320

gcctgcgctg ccatgactgt catcttcttc atcgttagtc aggtaacgga aggccattgg     1380

aaatggggcg gcgtcacagt ccaagtgaac agtgcctttt tcacaggcat ctatgggatg     1440

tggaatctgt atgtctttgc tctgatgttc ttgtatgcac catcccataa aaactatgga     1500

gaagaccagt ccaatggcga tctgggtgtc catagtgggg aagaactcca gctcaccacc     1560

actatcaccc atgtggacgg acccactgag atctacaagt tgacccgcaa ggaggcccag     1620

gagtag                                                                1626


<210>  102
<211>  507
<212>  PRT
<213>  homo sapiens

<400>  102

Met Ala Gly Ala Gly Pro Lys Arg Arg Ala Leu Ala Ala Pro Ala Ala 
1               5                   10                  15      


Glu Glu Lys Glu Glu Ala Arg Glu Lys Met Leu Ala Ala Lys Ser Ala 
            20                  25                  30          


Asp Gly Ser Ala Pro Ala Gly Glu Gly Glu Gly Val Thr Leu Gln Arg 
        35                  40                  45              


Asn Ile Thr Leu Leu Asn Gly Val Ala Ile Ile Val Gly Thr Ile Ile 
    50                  55                  60                  


Gly Ser Gly Ile Phe Val Thr Pro Thr Gly Val Leu Lys Glu Ala Gly 
65                  70                  75                  80  


Ser Pro Gly Leu Ala Leu Val Val Trp Ala Ala Cys Gly Val Phe Ser 
                85                  90                  95      


Ile Val Gly Ala Leu Cys Tyr Ala Glu Leu Gly Thr Thr Ile Ser Lys 
            100                 105                 110         


Ser Gly Gly Asp Tyr Ala Tyr Met Leu Glu Val Tyr Gly Ser Leu Pro 
        115                 120                 125             


Ala Phe Leu Lys Leu Trp Ile Glu Leu Leu Ile Ile Arg Pro Ser Ser 
    130                 135                 140                 


Gln Tyr Ile Val Ala Leu Val Phe Ala Thr Tyr Leu Leu Lys Pro Leu 
145                 150                 155                 160 


Phe Pro Thr Cys Pro Val Pro Glu Glu Ala Ala Lys Leu Val Ala Cys 
                165                 170                 175     


Leu Cys Val Leu Leu Leu Thr Ala Val Asn Cys Tyr Ser Val Lys Ala 
            180                 185                 190         


Ala Thr Arg Val Gln Asp Ala Phe Ala Ala Ala Lys Leu Leu Ala Leu 
        195                 200                 205             


Ala Leu Ile Ile Leu Leu Gly Phe Val Gln Ile Gly Lys Gly Asp Val 
    210                 215                 220                 


Ser Asn Leu Asp Pro Asn Phe Ser Phe Glu Gly Thr Lys Leu Asp Val 
225                 230                 235                 240 


Gly Asn Ile Val Leu Ala Leu Tyr Ser Gly Leu Phe Ala Tyr Gly Gly 
                245                 250                 255     


Trp Asn Tyr Leu Asn Phe Val Thr Glu Glu Met Ile Asn Pro Tyr Arg 
            260                 265                 270         


Asn Leu Pro Leu Ala Ile Ile Ile Ser Leu Pro Ile Val Thr Leu Val 
        275                 280                 285             


Tyr Val Leu Thr Asn Leu Ala Tyr Phe Thr Thr Leu Ser Thr Glu Gln 
    290                 295                 300                 


Met Leu Ser Ser Glu Ala Val Ala Val Asp Phe Gly Asn Tyr His Leu 
305                 310                 315                 320 


Gly Val Met Ser Trp Ile Ile Pro Val Phe Val Gly Leu Ser Cys Phe 
                325                 330                 335     


Gly Ser Val Asn Gly Ser Leu Phe Thr Ser Ser Arg Leu Phe Phe Val 
            340                 345                 350         


Gly Ser Arg Glu Gly His Leu Pro Ser Ile Leu Ser Met Ile His Pro 
        355                 360                 365             


Gln Leu Leu Thr Pro Val Pro Ser Leu Val Phe Thr Cys Val Met Thr 
    370                 375                 380                 


Leu Leu Tyr Ala Phe Ser Lys Asp Ile Phe Ser Val Ile Asn Phe Phe 
385                 390                 395                 400 


Ser Phe Phe Asn Trp Leu Cys Val Ala Leu Ala Ile Ile Gly Met Ile 
                405                 410                 415     


Trp Leu Arg His Arg Lys Pro Glu Leu Glu Arg Pro Ile Lys Val Asn 
            420                 425                 430         


Leu Ala Leu Pro Val Phe Phe Ile Leu Ala Cys Leu Phe Leu Ile Ala 
        435                 440                 445             


Val Ser Phe Trp Lys Thr Pro Val Glu Cys Gly Ile Gly Phe Thr Ile 
    450                 455                 460                 


Ile Leu Ser Gly Leu Pro Val Tyr Phe Phe Gly Val Trp Trp Lys Asn 
465                 470                 475                 480 


Lys Pro Lys Trp Leu Leu Gln Gly Ile Phe Ser Thr Thr Val Leu Cys 
                485                 490                 495     


Gln Lys Leu Met Gln Val Val Pro Gln Glu Thr 
            500                 505         


<210>  103
<211>  1524
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  103
atggcgggtg cgggcccgaa gcggcgcgcg ctagcggcgc cggcggccga ggagaaggaa       60

gaggcgcggg agaagatgct ggccgccaag agcgcggacg gctcggcgcc ggcaggcgag      120

ggcgagggcg tgaccctgca gcggaacatc acgctgctca acggcgtggc catcatcgtg      180

gggaccatta tcggctcggg catcttcgtg acgcccacgg gcgtgctcaa ggaggcaggc      240

tcgccggggc tggcgctggt ggtgtgggcc gcgtgcggcg tcttctccat cgtgggcgcg      300

ctctgctacg cggagctcgg caccaccatc tccaaatcgg gcggcgacta cgcctacatg      360

ctggaggtct acggctcgct gcccgccttc ctcaagctct ggatcgagct gctcatcatc      420

cggccttcat cgcagtacat cgtggccctg gtcttcgcca cctacctgct caagccgctc      480

ttccccacct gcccggtgcc cgaggaggca gccaagctcg tggcctgcct ctgcgtgctg      540

ctgctcacgg ccgtgaactg ctacagcgtg aaggccgcca cccgggtcca ggatgccttt      600

gccgccgcca agctcctggc cctggccctg atcatcctgc tgggcttcgt ccagatcggg      660

aagggtgatg tgtccaatct agatcccaac ttctcatttg aaggcaccaa actggatgtg      720

gggaacattg tgctggcatt atacagcggc ctctttgcct atggaggatg gaattacttg      780

aatttcgtca cagaggaaat gatcaacccc tacagaaacc tgcccctggc catcatcatc      840

tccctgccca tcgtgacgct ggtgtacgtg ctgaccaacc tggcctactt caccaccctg      900

tccaccgagc agatgctgtc gtccgaggcc gtggccgtgg acttcgggaa ctatcacctg      960

ggcgtcatgt cctggatcat ccccgtcttc gtgggcctgt cctgcttcgg ctccgtcaat     1020

gggtccctgt tcacatcctc caggctcttc ttcgtggggt cccgggaagg ccacctgccc     1080

tccatcctct ccatgatcca cccacagctc ctcacccccg tgccgtccct cgtgttcacg     1140

tgtgtgatga cgctgctcta cgccttctcc aaggacatct tctccgtcat caacttcttc     1200

agcttcttca actggctctg cgtggccctg gccatcatcg gcatgatctg gctgcgccac     1260

agaaagcctg agcttgagcg gcccatcaag gtgaacctgg ccctgcctgt gttcttcatc     1320

ctggcctgcc tcttcctgat cgccgtctcc ttctggaaga cacccgtgga gtgtggcatc     1380

ggcttcacca tcatcctcag cgggctgccc gtctacttct tcggggtctg gtggaaaaac     1440

aagcccaagt ggctcctcca gggcatcttc tccacgaccg tcctgtgtca gaagctcatg     1500

caggtggtcc cccaggagac atag                                            1524


<210>  104
<211>  478
<212>  PRT
<213>  homo sapiens

<400>  104

Met Pro Pro Met Pro Ser Ala Pro Pro Val His Pro Pro Pro Asp Gly 
1               5                   10                  15      


Gly Trp Gly Trp Ile Val Val Gly Ala Ala Phe Ile Ser Ile Gly Phe 
            20                  25                  30          


Ser Tyr Ala Phe Pro Lys Ala Val Thr Val Phe Phe Lys Glu Ile Gln 
        35                  40                  45              


Gln Ile Phe His Thr Thr Tyr Ser Glu Ile Ala Trp Ile Ser Ser Ile 
    50                  55                  60                  


Met Leu Ala Val Met Tyr Ala Gly Gly Pro Val Ser Ser Val Leu Val 
65                  70                  75                  80  


Asn Lys Tyr Gly Ser Arg Pro Val Val Ile Ala Gly Gly Leu Leu Cys 
                85                  90                  95      


Cys Leu Gly Met Val Leu Ala Ser Phe Ser Ser Ser Val Val Gln Leu 
            100                 105                 110         


Tyr Leu Thr Met Gly Phe Ile Thr Gly Leu Gly Leu Ala Phe Asn Leu 
        115                 120                 125             


Gln Pro Ala Leu Thr Ile Ile Gly Lys Tyr Phe Tyr Arg Lys Arg Pro 
    130                 135                 140                 


Met Ala Asn Gly Leu Ala Met Ala Gly Ser Pro Val Phe Leu Ser Ser 
145                 150                 155                 160 


Leu Ala Pro Phe Asn Gln Tyr Leu Phe Asn Thr Phe Gly Trp Lys Gly 
                165                 170                 175     


Ser Phe Leu Ile Leu Gly Ser Leu Leu Leu Asn Ala Cys Val Ala Gly 
            180                 185                 190         


Ser Leu Met Arg Pro Leu Gly Pro Asn Gln Thr Thr Ser Lys Ser Lys 
        195                 200                 205             


Asn Lys Thr Gly Lys Thr Glu Asp Asp Ser Ser Pro Lys Lys Ile Lys 
    210                 215                 220                 


Thr Lys Lys Ser Thr Trp Glu Lys Val Asn Lys Tyr Leu Asp Phe Ser 
225                 230                 235                 240 


Leu Phe Lys His Arg Gly Phe Leu Ile Tyr Leu Ser Gly Asn Val Ile 
                245                 250                 255     


Met Phe Leu Gly Phe Phe Ala Pro Ile Ile Phe Leu Ala Pro Tyr Ala 
            260                 265                 270         


Lys Asp Gln Gly Ile Asp Glu Tyr Ser Ala Ala Phe Leu Leu Ser Val 
        275                 280                 285             


Met Ala Phe Val Asp Met Phe Ala Arg Pro Ser Val Gly Leu Ile Ala 
    290                 295                 300                 


Asn Ser Lys Tyr Ile Arg Pro Arg Ile Gln Tyr Phe Phe Ser Phe Ala 
305                 310                 315                 320 


Ile Met Phe Asn Gly Val Cys His Leu Leu Cys Pro Leu Ala Gln Asp 
                325                 330                 335     


Tyr Thr Ser Leu Val Leu Tyr Ala Val Phe Phe Gly Leu Gly Phe Gly 
            340                 345                 350         


Ser Val Ser Ser Val Leu Phe Glu Thr Leu Met Asp Leu Val Gly Ala 
        355                 360                 365             


Pro Arg Phe Ser Ser Ala Val Gly Leu Val Thr Ile Val Glu Cys Gly 
    370                 375                 380                 


Pro Val Leu Leu Gly Pro Pro Leu Ala Gly Lys Leu Val Asp Leu Thr 
385                 390                 395                 400 


Gly Glu Tyr Lys Tyr Met Tyr Met Ser Cys Gly Ala Ile Val Val Ala 
                405                 410                 415     


Ala Ser Val Trp Leu Leu Ile Gly Asn Ala Ile Asn Tyr Arg Leu Leu 
            420                 425                 430         


Ala Lys Glu Arg Lys Glu Glu Asn Ala Arg Gln Lys Thr Arg Glu Ser 
        435                 440                 445             


Glu Pro Leu Ser Lys Ser Lys His Ser Glu Asp Val Asn Val Lys Val 
    450                 455                 460                 


Ser Asn Ala Gln Ser Val Thr Ser Glu Arg Glu Thr Asn Ile 
465                 470                 475             


<210>  105
<211>  1437
<212>  DNA
<213>  artificial sequence

<220>
<223>  cDNA

<400>  105
atgccaccaa tgccaagtgc cccacctgtg catccacctc cagatggagg atggggttgg       60

attgtggttg gagcagcttt tatctccatt ggattttcct atgcattccc caaagctgtc      120

accgtattct tcaaagaaat tcagcaaata ttccacacta cctacagtga aatagcatgg      180

atttcatcca ttatgctggc tgttatgtac gcaggaggtc ctgtaagtag tgttttggtg      240

aataaatacg gcagccggcc ggtggtgata gcaggaggct tattatgctg tcttggaatg      300

gtgttggcct cctttagtag cagcgtggta cagctgtacc tcactatggg attcattaca      360

ggtttaggtt tagccttcaa cctgcaaccc gccttaacca taattggcaa atacttctat      420

aggaagcgac ccatggcaaa tggattggcc atggcaggaa gtcctgtttt cttaagttca      480

ttggctcctt tcaatcagta cctttttaat acttttggct ggaaaggaag cttcctgatt      540

ttgggaagtc tacttttgaa tgcctgtgtg gctggttccc tcatgagacc ccttggaccc      600

aatcaaacca cttctaagtc taaaaataag actggcaaaa cagaagatga ttcaagccca      660

aagaaaatca aaacgaagaa atcaacttgg gaaaaagtta ataagtattt agatttctcc      720

ctttttaagc atagaggatt tctgatatat ctgtctggaa atgtcattat gttcctaggt      780

ttttttgccc ccattatatt cttggctcca tatgctaaag accaaggaat tgatgagtac      840

tcggcagctt ttctgctatc tgttatggct ttcgttgata tgtttgctag gccttctgta      900

ggattaattg caaactccaa atatattcga cctcgaattc agtacttctt cagttttgca      960

atcatgttca atggagtgtg tcacctcttg tgcccactgg cacaggacta cacaagcctg     1020

gtattatatg ctgtattttt tggccttgga tttgggagtg ttagcagtgt tctctttgaa     1080

actctcatgg acctcgtggg tgcaccaaga ttttccagtg ccgtcggact tgtcacaatt     1140

gtggagtgtg gcccagttct tcttggccct cctcttgcag gtaaattggt ggatttaact     1200

ggagaatata aatacatgta catgtcctgt ggggctattg tggtagcagc aagcgtgtgg     1260

ctgctcattg gcaatgctat caactataga ttgcttgcaa aggaaaggaa ggaggaaaat     1320

gcaaggcaga agaccagaga atctgaaccc ttgagcaaat ctaaacattc ggaagatgtt     1380

aacgtcaaag tttcaaatgc acagagtgta acctcagaaa gagaaactaa catttaa        1437


