               SEQUENCE LISTING

<110> Sylentis S.A.U.

<120> siRNA and compositions for prophylactic and therapeutic treatment of virus diseases

<130> PC931417WO

<150> EP20382535.1
<151> 2020-06-19

<160> 1056

<170> BiSSAP 1.3.6

<210> 1
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 1
ttttggacaa atctgtact                                                 19


<210> 2
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 2
attttggaca aatctgtac                                                 19


<210> 3
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 3
gattttggac aaatctgta                                                 19


<210> 4
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 4
agattttgga caaatctgt                                                 19


<210> 5
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 5
agaaaccaaa catagatgt                                                 19


<210> 6
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 6
accaaacata gatgttact                                                 19


<210> 7
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 7
aaccaaacat agatgttac                                                 19


<210> 8
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 8
atttgcttgg tgatatgtg                                                 19


<210> 9
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 9
aaaccaaaca tagatgtta                                                 19


<210> 10
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 10
gaaaccaaac atagatgtt                                                 19


<210> 11
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 11
cagaaaccaa acatagatg                                                 19


<210> 12
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 12
ccaaacatag atgttactg                                                 19


<210> 13
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 13
ggtagatttt ggacaaatc                                                 19


<210> 14
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 14
gtagattttg gacaaatct                                                 19


<210> 15
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 15
aatcatgtca ctttctgca                                                 19


<210> 16
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 16
tttgcttggt gatatgtgg                                                 19


<210> 17
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 17
tggaggtgga tggtcttta                                                 19


<210> 18
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 18
tagattttgg acaaatctg                                                 19


<210> 19
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 19
agtggaggtg gatggtctt                                                 19


<210> 20
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 20
gggtagattt tggacaaat                                                 19


<210> 21
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 21
gtggaggtgg atggtcttt                                                 19


<210> 22
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 22
aaatcatgtc actttctgc                                                 19


<210> 23
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 23
aattccagtt tcaagaagc                                                 19


<210> 24
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 24
attccagttt caagaagca                                                 19


<210> 25
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 25
ttgcttggtg atatgtggg                                                 19


<210> 26
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 26
atcatgtcac tttctgcag                                                 19


<210> 27
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 27
tgcttggtga tatgtgggg                                                 19


<210> 28
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 28
ttggtgatat gtggggtag                                                 19


<210> 29
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 29
taatgattac tcattcatt                                                 19


<210> 30
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 30
tcatgtcact ttctgcagc                                                 19


<210> 31
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 31
catgtcactt tctgcagcc                                                 19


<210> 32
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 32
tgatatgtgg ggtagattt                                                 19


<210> 33
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 33
gatatgtggg gtagatttt                                                 19


<210> 34
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 34
gtgatatgtg gggtagatt                                                 19


<210> 35
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 35
atatgtgggg tagattttg                                                 19


<210> 36
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 36
ggtgatatgt ggggtagat                                                 19


<210> 37
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 37
atgtggggta gattttgga                                                 19


<210> 38
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 38
tgtggggtag attttggac                                                 19


<210> 39
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 39
ggggtagatt ttggacaaa                                                 19


<210> 40
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 40
gtggggtaga ttttggaca                                                 19


<210> 41
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 41
tggggtagat tttggacaa                                                 19


<210> 42
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 42
tggtgatatg tggggtaga                                                 19


<210> 43
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 43
gcttggtgat atgtggggt                                                 19


<210> 44
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 44
cttggtgata tgtggggta                                                 19


<210> 45
<211> 19
<212> DNA
<213> Homo sapiens


<220> 
<223> cDNA

<400> 45
tatgtggggt agattttgg                                                 19


<210> 46
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 46
aguacagauu uguccaaaa                                                 19


<210> 47
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 47
guacagauuu guccaaaau                                                 19


<210> 48
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 48
uacagauuug uccaaaauc                                                 19


<210> 49
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 49
acagauuugu ccaaaaucu                                                 19


<210> 50
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 50
acaucuaugu uugguuucu                                                 19


<210> 51
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 51
aguaacaucu auguuuggu                                                 19


<210> 52
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 52
guaacaucua uguuugguu                                                 19


<210> 53
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 53
cacauaucac caagcaaau                                                 19


<210> 54
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 54
uaacaucuau guuugguuu                                                 19


<210> 55
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 55
aacaucuaug uuugguuuc                                                 19


<210> 56
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 56
caucuauguu ugguuucug                                                 19


<210> 57
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 57
caguaacauc uauguuugg                                                 19


<210> 58
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 58
gauuugucca aaaucuacc                                                 19


<210> 59
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 59
agauuugucc aaaaucuac                                                 19


<210> 60
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 60
ugcagaaagu gacaugauu                                                 19


<210> 61
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 61
ccacauauca ccaagcaaa                                                 19


<210> 62
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 62
uaaagaccau ccaccucca                                                 19


<210> 63
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 63
cagauuuguc caaaaucua                                                 19


<210> 64
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 64
aagaccaucc accuccacu                                                 19


<210> 65
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 65
auuuguccaa aaucuaccc                                                 19


<210> 66
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 66
aaagaccauc caccuccac                                                 19


<210> 67
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 67
gcagaaagug acaugauuu                                                 19


<210> 68
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 68
gcuucuugaa acuggaauu                                                 19


<210> 69
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 69
ugcuucuuga aacuggaau                                                 19


<210> 70
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 70
cccacauauc accaagcaa                                                 19


<210> 71
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 71
cugcagaaag ugacaugau                                                 19


<210> 72
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 72
ccccacauau caccaagca                                                 19


<210> 73
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 73
cuaccccaca uaucaccaa                                                 19


<210> 74
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 74
aaugaaugag uaaucauua                                                 19


<210> 75
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 75
gcugcagaaa gugacauga                                                 19


<210> 76
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 76
ggcugcagaa agugacaug                                                 19


<210> 77
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 77
aaaucuaccc cacauauca                                                 19


<210> 78
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 78
aaaaucuacc ccacauauc                                                 19


<210> 79
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 79
aaucuacccc acauaucac                                                 19


<210> 80
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 80
caaaaucuac cccacauau                                                 19


<210> 81
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 81
aucuacccca cauaucacc                                                 19


<210> 82
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 82
uccaaaaucu accccacau                                                 19


<210> 83
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 83
guccaaaauc uaccccaca                                                 19


<210> 84
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 84
uuuguccaaa aucuacccc                                                 19


<210> 85
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 85
uguccaaaau cuaccccac                                                 19


<210> 86
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 86
uuguccaaaa ucuacccca                                                 19


<210> 87
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 87
ucuaccccac auaucacca                                                 19


<210> 88
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 88
accccacaua ucaccaagc                                                 19


<210> 89
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 89
uaccccacau aucaccaag                                                 19


<210> 90
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 90
ccaaaaucua ccccacaua                                                 19


<210> 91
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 91
uuuuggacaa aucuguacu                                                 19


<210> 92
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 92
auuuuggaca aaucuguac                                                 19


<210> 93
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 93
gauuuuggac aaaucugua                                                 19


<210> 94
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 94
agauuuugga caaaucugu                                                 19


<210> 95
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 95
agaaaccaaa cauagaugu                                                 19


<210> 96
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 96
accaaacaua gauguuacu                                                 19


<210> 97
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 97
aaccaaacau agauguuac                                                 19


<210> 98
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 98
auuugcuugg ugauaugug                                                 19


<210> 99
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 99
aaaccaaaca uagauguua                                                 19


<210> 100
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 100
gaaaccaaac auagauguu                                                 19


<210> 101
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 101
cagaaaccaa acauagaug                                                 19


<210> 102
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 102
ccaaacauag auguuacug                                                 19


<210> 103
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 103
gguagauuuu ggacaaauc                                                 19


<210> 104
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 104
guagauuuug gacaaaucu                                                 19


<210> 105
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 105
aaucauguca cuuucugca                                                 19


<210> 106
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 106
uuugcuuggu gauaugugg                                                 19


<210> 107
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 107
uggaggugga uggucuuua                                                 19


<210> 108
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 108
uagauuuugg acaaaucug                                                 19


<210> 109
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 109
aguggaggug gauggucuu                                                 19


<210> 110
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 110
ggguagauuu uggacaaau                                                 19


<210> 111
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 111
guggaggugg auggucuuu                                                 19


<210> 112
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 112
aaaucauguc acuuucugc                                                 19


<210> 113
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 113
aauuccaguu ucaagaagc                                                 19


<210> 114
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 114
auuccaguuu caagaagca                                                 19


<210> 115
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 115
uugcuuggug auauguggg                                                 19


<210> 116
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 116
aucaugucac uuucugcag                                                 19


<210> 117
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 117
ugcuugguga uaugugggg                                                 19


<210> 118
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 118
uuggugauau gugggguag                                                 19


<210> 119
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 119
uaaugauuac ucauucauu                                                 19


<210> 120
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 120
ucaugucacu uucugcagc                                                 19


<210> 121
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 121
caugucacuu ucugcagcc                                                 19


<210> 122
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 122
ugauaugugg gguagauuu                                                 19


<210> 123
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 123
gauauguggg guagauuuu                                                 19


<210> 124
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 124
gugauaugug ggguagauu                                                 19


<210> 125
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 125
auaugugggg uagauuuug                                                 19


<210> 126
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 126
ggugauaugu gggguagau                                                 19


<210> 127
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 127
auguggggua gauuuugga                                                 19


<210> 128
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 128
ugugggguag auuuuggac                                                 19


<210> 129
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 129
gggguagauu uuggacaaa                                                 19


<210> 130
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 130
gugggguaga uuuuggaca                                                 19


<210> 131
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 131
ugggguagau uuuggacaa                                                 19


<210> 132
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 132
uggugauaug ugggguaga                                                 19


<210> 133
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 133
gcuuggugau auguggggu                                                 19


<210> 134
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 134
cuuggugaua uguggggua                                                 19


<210> 135
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 135
uauguggggu agauuuugg                                                 19


<210> 136
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 136
aguacagauu uguccaaaau u                                              21


<210> 137
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 137
aguacagauu uguccaaaau u                                              21


<210> 138
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 138
aguacagauu uguccaaaau u                                              21


<210> 139
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 139
aguacagauu uguccaaaau u                                              21


<210> 140
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 140
aguacagauu uguccaaaan n                                              21


<210> 141
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 141
aguacagauu uguccaaaan n                                              21


<210> 142
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 142
aguacagauu uguccaaaan n                                              21


<210> 143
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 143
aguacagauu uguccaaaan n                                              21


<210> 144
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 144
guacagauuu guccaaaauu u                                              21


<210> 145
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 145
guacagauuu guccaaaauu u                                              21


<210> 146
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 146
guacagauuu guccaaaauu u                                              21


<210> 147
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 147
guacagauuu guccaaaauu u                                              21


<210> 148
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 148
guacagauuu guccaaaaun n                                              21


<210> 149
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 149
guacagauuu guccaaaaun n                                              21


<210> 150
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 150
guacagauuu guccaaaaun n                                              21


<210> 151
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 151
guacagauuu guccaaaaun n                                              21


<210> 152
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 152
uacagauuug uccaaaaucu u                                              21


<210> 153
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 153
uacagauuug uccaaaaucu u                                              21


<210> 154
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 154
uacagauuug uccaaaaucu u                                              21


<210> 155
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 155
uacagauuug uccaaaaucu u                                              21


<210> 156
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 156
uacagauuug uccaaaaucn n                                              21


<210> 157
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 157
uacagauuug uccaaaaucn n                                              21


<210> 158
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 158
uacagauuug uccaaaaucn n                                              21


<210> 159
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 159
uacagauuug uccaaaaucn n                                              21


<210> 160
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 160
acagauuugu ccaaaaucuu u                                              21


<210> 161
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 161
acagauuugu ccaaaaucuu u                                              21


<210> 162
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 162
acagauuugu ccaaaaucuu u                                              21


<210> 163
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 163
acagauuugu ccaaaaucuu u                                              21


<210> 164
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 164
acagauuugu ccaaaaucun n                                              21


<210> 165
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 165
acagauuugu ccaaaaucun n                                              21


<210> 166
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 166
acagauuugu ccaaaaucun n                                              21


<210> 167
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 167
acagauuugu ccaaaaucun n                                              21


<210> 168
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 168
aguaacaucu auguuugguu u                                              21


<210> 169
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 169
aguaacaucu auguuugguu u                                              21


<210> 170
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 170
aguaacaucu auguuugguu u                                              21


<210> 171
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 171
aguaacaucu auguuugguu u                                              21


<210> 172
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 172
aguaacaucu auguuuggun n                                              21


<210> 173
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 173
aguaacaucu auguuuggun n                                              21


<210> 174
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 174
aguaacaucu auguuuggun n                                              21


<210> 175
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 175
aguaacaucu auguuuggun n                                              21


<210> 176
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 176
guaacaucua uguuugguuu u                                              21


<210> 177
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 177
guaacaucua uguuugguuu u                                              21


<210> 178
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 178
guaacaucua uguuugguuu u                                              21


<210> 179
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 179
guaacaucua uguuugguuu u                                              21


<210> 180
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 180
guaacaucua uguuugguun n                                              21


<210> 181
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 181
guaacaucua uguuugguun n                                              21


<210> 182
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 182
guaacaucua uguuugguun n                                              21


<210> 183
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 183
guaacaucua uguuugguun n                                              21


<210> 184
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 184
uaacaucuau guuugguuuu u                                              21


<210> 185
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 185
uaacaucuau guuugguuuu u                                              21


<210> 186
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 186
uaacaucuau guuugguuuu u                                              21


<210> 187
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 187
uaacaucuau guuugguuuu u                                              21


<210> 188
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 188
uaacaucuau guuugguuun n                                              21


<210> 189
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 189
uaacaucuau guuugguuun n                                              21


<210> 190
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 190
uaacaucuau guuugguuun n                                              21


<210> 191
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 191
uaacaucuau guuugguuun n                                              21


<210> 192
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 192
aacaucuaug uuugguuucu u                                              21


<210> 193
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 193
aacaucuaug uuugguuucu u                                              21


<210> 194
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 194
aacaucuaug uuugguuucu u                                              21


<210> 195
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 195
aacaucuaug uuugguuucu u                                              21


<210> 196
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 196
aacaucuaug uuugguuucn n                                              21


<210> 197
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 197
aacaucuaug uuugguuucn n                                              21


<210> 198
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 198
aacaucuaug uuugguuucn n                                              21


<210> 199
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 199
aacaucuaug uuugguuucn n                                              21


<210> 200
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 200
caguaacauc uauguuuggu u                                              21


<210> 201
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 201
caguaacauc uauguuuggu u                                              21


<210> 202
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 202
caguaacauc uauguuuggu u                                              21


<210> 203
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 203
caguaacauc uauguuuggu u                                              21


<210> 204
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 204
caguaacauc uauguuuggn n                                              21


<210> 205
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 205
caguaacauc uauguuuggn n                                              21


<210> 206
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 206
caguaacauc uauguuuggn n                                              21


<210> 207
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 207
caguaacauc uauguuuggn n                                              21


<210> 208
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 208
gauuugucca aaaucuaccu u                                              21


<210> 209
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 209
gauuugucca aaaucuaccu u                                              21


<210> 210
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 210
gauuugucca aaaucuaccu u                                              21


<210> 211
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 211
gauuugucca aaaucuaccu u                                              21


<210> 212
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 212
gauuugucca aaaucuaccn n                                              21


<210> 213
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 213
gauuugucca aaaucuaccn n                                              21


<210> 214
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 214
gauuugucca aaaucuaccn n                                              21


<210> 215
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 215
gauuugucca aaaucuaccn n                                              21


<210> 216
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 216
agauuugucc aaaaucuacu u                                              21


<210> 217
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 217
agauuugucc aaaaucuacu u                                              21


<210> 218
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 218
agauuugucc aaaaucuacu u                                              21


<210> 219
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 219
agauuugucc aaaaucuacu u                                              21


<210> 220
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 220
agauuugucc aaaaucuacn n                                              21


<210> 221
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 221
agauuugucc aaaaucuacn n                                              21


<210> 222
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 222
agauuugucc aaaaucuacn n                                              21


<210> 223
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 223
agauuugucc aaaaucuacn n                                              21


<210> 224
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 224
uaaagaccau ccaccuccau u                                              21


<210> 225
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 225
uaaagaccau ccaccuccau u                                              21


<210> 226
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 226
uaaagaccau ccaccuccau u                                              21


<210> 227
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 227
uaaagaccau ccaccuccau u                                              21


<210> 228
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 228
uaaagaccau ccaccuccan n                                              21


<210> 229
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 229
uaaagaccau ccaccuccan n                                              21


<210> 230
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 230
uaaagaccau ccaccuccan n                                              21


<210> 231
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 231
uaaagaccau ccaccuccan n                                              21


<210> 232
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 232
cagauuuguc caaaaucuau u                                              21


<210> 233
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 233
cagauuuguc caaaaucuau u                                              21


<210> 234
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 234
cagauuuguc caaaaucuau u                                              21


<210> 235
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 235
cagauuuguc caaaaucuau u                                              21


<210> 236
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 236
cagauuuguc caaaaucuan n                                              21


<210> 237
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 237
cagauuuguc caaaaucuan n                                              21


<210> 238
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 238
cagauuuguc caaaaucuan n                                              21


<210> 239
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 239
cagauuuguc caaaaucuan n                                              21


<210> 240
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 240
auuuguccaa aaucuacccu u                                              21


<210> 241
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 241
auuuguccaa aaucuacccu u                                              21


<210> 242
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 242
auuuguccaa aaucuacccu u                                              21


<210> 243
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 243
auuuguccaa aaucuacccu u                                              21


<210> 244
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 244
auuuguccaa aaucuacccn n                                              21


<210> 245
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 245
auuuguccaa aaucuacccn n                                              21


<210> 246
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 246
auuuguccaa aaucuacccn n                                              21


<210> 247
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 247
auuuguccaa aaucuacccn n                                              21


<210> 248
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 248
cccacauauc accaagcaau u                                              21


<210> 249
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 249
cccacauauc accaagcaau u                                              21


<210> 250
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 250
cccacauauc accaagcaau u                                              21


<210> 251
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 251
cccacauauc accaagcaau u                                              21


<210> 252
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 252
cccacauauc accaagcaan n                                              21


<210> 253
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 253
cccacauauc accaagcaan n                                              21


<210> 254
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 254
cccacauauc accaagcaan n                                              21


<210> 255
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 255
cccacauauc accaagcaan n                                              21


<210> 256
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 256
cugcagaaag ugacaugauu u                                              21


<210> 257
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 257
cugcagaaag ugacaugauu u                                              21


<210> 258
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 258
cugcagaaag ugacaugauu u                                              21


<210> 259
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 259
cugcagaaag ugacaugauu u                                              21


<210> 260
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 260
cugcagaaag ugacaugaun n                                              21


<210> 261
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 261
cugcagaaag ugacaugaun n                                              21


<210> 262
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 262
cugcagaaag ugacaugaun n                                              21


<210> 263
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 263
cugcagaaag ugacaugaun n                                              21


<210> 264
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 264
ccccacauau caccaagcau u                                              21


<210> 265
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 265
ccccacauau caccaagcau u                                              21


<210> 266
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 266
ccccacauau caccaagcau u                                              21


<210> 267
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 267
ccccacauau caccaagcau u                                              21


<210> 268
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 268
ccccacauau caccaagcan n                                              21


<210> 269
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 269
ccccacauau caccaagcan n                                              21


<210> 270
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 270
ccccacauau caccaagcan n                                              21


<210> 271
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 271
ccccacauau caccaagcan n                                              21


<210> 272
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 272
cuaccccaca uaucaccaau u                                              21


<210> 273
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 273
cuaccccaca uaucaccaau u                                              21


<210> 274
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 274
cuaccccaca uaucaccaau u                                              21


<210> 275
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 275
cuaccccaca uaucaccaau u                                              21


<210> 276
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 276
cuaccccaca uaucaccaan n                                              21


<210> 277
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 277
cuaccccaca uaucaccaan n                                              21


<210> 278
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 278
cuaccccaca uaucaccaan n                                              21


<210> 279
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 279
cuaccccaca uaucaccaan n                                              21


<210> 280
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 280
gcugcagaaa gugacaugau u                                              21


<210> 281
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 281
gcugcagaaa gugacaugau u                                              21


<210> 282
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 282
gcugcagaaa gugacaugau u                                              21


<210> 283
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 283
gcugcagaaa gugacaugau u                                              21


<210> 284
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 284
gcugcagaaa gugacaugan n                                              21


<210> 285
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 285
gcugcagaaa gugacaugan n                                              21


<210> 286
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 286
gcugcagaaa gugacaugan n                                              21


<210> 287
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 287
gcugcagaaa gugacaugan n                                              21


<210> 288
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 288
ggcugcagaa agugacaugu u                                              21


<210> 289
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 289
ggcugcagaa agugacaugu u                                              21


<210> 290
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 290
ggcugcagaa agugacaugu u                                              21


<210> 291
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 291
ggcugcagaa agugacaugu u                                              21


<210> 292
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 292
ggcugcagaa agugacaugn n                                              21


<210> 293
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 293
ggcugcagaa agugacaugn n                                              21


<210> 294
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 294
ggcugcagaa agugacaugn n                                              21


<210> 295
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 295
ggcugcagaa agugacaugn n                                              21


<210> 296
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 296
aaaucuaccc cacauaucau u                                              21


<210> 297
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 297
aaaucuaccc cacauaucau u                                              21


<210> 298
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 298
aaaucuaccc cacauaucau u                                              21


<210> 299
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 299
aaaucuaccc cacauaucau u                                              21


<210> 300
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 300
aaaucuaccc cacauaucan n                                              21


<210> 301
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 301
aaaucuaccc cacauaucan n                                              21


<210> 302
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 302
aaaucuaccc cacauaucan n                                              21


<210> 303
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 303
aaaucuaccc cacauaucan n                                              21


<210> 304
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 304
aaaaucuacc ccacauaucu u                                              21


<210> 305
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 305
aaaaucuacc ccacauaucu u                                              21


<210> 306
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 306
aaaaucuacc ccacauaucu u                                              21


<210> 307
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 307
aaaaucuacc ccacauaucu u                                              21


<210> 308
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 308
aaaaucuacc ccacauaucn n                                              21


<210> 309
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 309
aaaaucuacc ccacauaucn n                                              21


<210> 310
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 310
aaaaucuacc ccacauaucn n                                              21


<210> 311
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 311
aaaaucuacc ccacauaucn n                                              21


<210> 312
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 312
aaucuacccc acauaucacu u                                              21


<210> 313
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 313
aaucuacccc acauaucacu u                                              21


<210> 314
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 314
aaucuacccc acauaucacu u                                              21


<210> 315
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 315
aaucuacccc acauaucacu u                                              21


<210> 316
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 316
aaucuacccc acauaucacn n                                              21


<210> 317
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 317
aaucuacccc acauaucacn n                                              21


<210> 318
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 318
aaucuacccc acauaucacn n                                              21


<210> 319
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 319
aaucuacccc acauaucacn n                                              21


<210> 320
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 320
caaaaucuac cccacauauu u                                              21


<210> 321
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 321
caaaaucuac cccacauauu u                                              21


<210> 322
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 322
caaaaucuac cccacauauu u                                              21


<210> 323
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 323
caaaaucuac cccacauauu u                                              21


<210> 324
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 324
caaaaucuac cccacauaun n                                              21


<210> 325
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 325
caaaaucuac cccacauaun n                                              21


<210> 326
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 326
caaaaucuac cccacauaun n                                              21


<210> 327
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 327
caaaaucuac cccacauaun n                                              21


<210> 328
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 328
aucuacccca cauaucaccu u                                              21


<210> 329
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 329
aucuacccca cauaucaccu u                                              21


<210> 330
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 330
aucuacccca cauaucaccu u                                              21


<210> 331
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 331
aucuacccca cauaucaccu u                                              21


<210> 332
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 332
aucuacccca cauaucaccn n                                              21


<210> 333
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 333
aucuacccca cauaucaccn n                                              21


<210> 334
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 334
aucuacccca cauaucaccn n                                              21


<210> 335
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 335
aucuacccca cauaucaccn n                                              21


<210> 336
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 336
uuuguccaaa aucuaccccu u                                              21


<210> 337
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 337
uuuguccaaa aucuaccccu u                                              21


<210> 338
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 338
uuuguccaaa aucuaccccu u                                              21


<210> 339
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 339
uuuguccaaa aucuaccccu u                                              21


<210> 340
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 340
uuuguccaaa aucuaccccn n                                              21


<210> 341
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 341
uuuguccaaa aucuaccccn n                                              21


<210> 342
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 342
uuuguccaaa aucuaccccn n                                              21


<210> 343
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 343
uuuguccaaa aucuaccccn n                                              21


<210> 344
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 344
uguccaaaau cuaccccacu u                                              21


<210> 345
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 345
uguccaaaau cuaccccacu u                                              21


<210> 346
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 346
uguccaaaau cuaccccacu u                                              21


<210> 347
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 347
uguccaaaau cuaccccacu u                                              21


<210> 348
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 348
uguccaaaau cuaccccacn n                                              21


<210> 349
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 349
uguccaaaau cuaccccacn n                                              21


<210> 350
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 350
uguccaaaau cuaccccacn n                                              21


<210> 351
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 351
uguccaaaau cuaccccacn n                                              21


<210> 352
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 352
uuguccaaaa ucuaccccau u                                              21


<210> 353
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 353
uuguccaaaa ucuaccccau u                                              21


<210> 354
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 354
uuguccaaaa ucuaccccau u                                              21


<210> 355
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 355
uuguccaaaa ucuaccccau u                                              21


<210> 356
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 356
uuguccaaaa ucuaccccan n                                              21


<210> 357
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 357
uuguccaaaa ucuaccccan n                                              21


<210> 358
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 358
uuguccaaaa ucuaccccan n                                              21


<210> 359
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 359
uuguccaaaa ucuaccccan n                                              21


<210> 360
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 360
ucuaccccac auaucaccau u                                              21


<210> 361
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 361
ucuaccccac auaucaccau u                                              21


<210> 362
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 362
ucuaccccac auaucaccau u                                              21


<210> 363
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 363
ucuaccccac auaucaccau u                                              21


<210> 364
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 364
ucuaccccac auaucaccan n                                              21


<210> 365
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 365
ucuaccccac auaucaccan n                                              21


<210> 366
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 366
ucuaccccac auaucaccan n                                              21


<210> 367
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 367
ucuaccccac auaucaccan n                                              21


<210> 368
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 368
guccaaaauc uaccccacau u                                              21


<210> 369
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 369
guccaaaauc uaccccacau u                                              21


<210> 370
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 370
guccaaaauc uaccccacau u                                              21


<210> 371
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 371
guccaaaauc uaccccacau u                                              21


<210> 372
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 372
guccaaaauc uaccccacan n                                              21


<210> 373
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 373
guccaaaauc uaccccacan n                                              21


<210> 374
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 374
guccaaaauc uaccccacan n                                              21


<210> 375
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 375
guccaaaauc uaccccacan n                                              21


<210> 376
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 376
uccaaaaucu accccacauu u                                              21


<210> 377
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 377
uccaaaaucu accccacauu u                                              21


<210> 378
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 378
uccaaaaucu accccacauu u                                              21


<210> 379
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 379
uccaaaaucu accccacauu u                                              21


<210> 380
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 380
uccaaaaucu accccacaun n                                              21


<210> 381
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 381
uccaaaaucu accccacaun n                                              21


<210> 382
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 382
uccaaaaucu accccacaun n                                              21


<210> 383
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 383
uccaaaaucu accccacaun n                                              21


<210> 384
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 384
accccacaua ucaccaagcu u                                              21


<210> 385
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 385
accccacaua ucaccaagcu u                                              21


<210> 386
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 386
accccacaua ucaccaagcu u                                              21


<210> 387
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 387
accccacaua ucaccaagcu u                                              21


<210> 388
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 388
accccacaua ucaccaagcn n                                              21


<210> 389
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 389
accccacaua ucaccaagcn n                                              21


<210> 390
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 390
accccacaua ucaccaagcn n                                              21


<210> 391
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 391
accccacaua ucaccaagcn n                                              21


<210> 392
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 392
uaccccacau aucaccaagu u                                              21


<210> 393
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 393
uaccccacau aucaccaagu u                                              21


<210> 394
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 394
uaccccacau aucaccaagu u                                              21


<210> 395
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 395
uaccccacau aucaccaagu u                                              21


<210> 396
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 396
uaccccacau aucaccaagn n                                              21


<210> 397
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 397
uaccccacau aucaccaagn n                                              21


<210> 398
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 398
uaccccacau aucaccaagn n                                              21


<210> 399
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 399
uaccccacau aucaccaagn n                                              21


<210> 400
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 400
ccaaaaucua ccccacauau u                                              21


<210> 401
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 401
ccaaaaucua ccccacauau u                                              21


<210> 402
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 402
ccaaaaucua ccccacauau u                                              21


<210> 403
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 403
ccaaaaucua ccccacauau u                                              21


<210> 404
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 404
ccaaaaucua ccccacauan n                                              21


<210> 405
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 405
ccaaaaucua ccccacauan n                                              21


<210> 406
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 406
ccaaaaucua ccccacauan n                                              21


<210> 407
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 407
ccaaaaucua ccccacauan n                                              21


<210> 408
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 408
guacagauuu guccaaaaun                                                20


<210> 409
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 409
uacagauuug uccaaaaucn                                                20


<210> 410
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 410
uacagauuug uccaaaaucn n                                              21


<210> 411
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 411
uacagauuug uccaaaaucu u                                              21


<210> 412
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 412
acagauuugu ccaaaaucun                                                20


<210> 413
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 413
acagauuugu ccaaaaucun n                                              21


<210> 414
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 414
acagauuugu ccaaaaucuu u                                              21


<210> 415
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 415
acaucuaugu uugguuucun                                                20


<210> 416
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 416
aguaacaucu auguuuggun                                                20


<210> 417
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 417
guaacaucua uguuugguun                                                20


<210> 418
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 418
guaacaucua uguuugguun n                                              21


<210> 419
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 419
guaacaucua uguuugguuu u                                              21


<210> 420
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 420
uaacaucuau guuugguuun                                                20


<210> 421
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 421
uaacaucuau guuugguuun n                                              21


<210> 422
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 422
uaacaucuau guuugguuuu u                                              21


<210> 423
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 423
aacaucuaug uuugguuucn                                                20


<210> 424
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 424
aacaucuaug uuugguuucn n                                              21


<210> 425
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 425
aacaucuaug uuugguuucu u                                              21


<210> 426
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 426
gauuugucca aaaucuaccn                                                20


<210> 427
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 427
gauuugucca aaaucuaccn n                                              21


<210> 428
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 428
gauuugucca aaaucuaccu u                                              21


<210> 429
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 429
agauuugucc aaaaucuacn                                                20


<210> 430
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 430
agauuugucc aaaaucuacn n                                              21


<210> 431
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 431
agauuugucc aaaaucuacu u                                              21


<210> 432
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 432
ugcagaaagu gacaugauun                                                20


<210> 433
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 433
ccacauauca ccaagcaaan                                                20


<210> 434
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 434
cagauuuguc caaaaucuan                                                20


<210> 435
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 435
cagauuuguc caaaaucuan n                                              21


<210> 436
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 436
cagauuuguc caaaaucuau u                                              21


<210> 437
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 437
auuuguccaa aaucuacccn                                                20


<210> 438
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 438
auuuguccaa aaucuacccn n                                              21


<210> 439
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 439
auuuguccaa aaucuacccu u                                              21


<210> 440
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 440
aaagaccauc caccuccacn                                                20


<210> 441
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 441
cccacauauc accaagcaan                                                20


<210> 442
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 442
cccacauauc accaagcaan n                                              21


<210> 443
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 443
cccacauauc accaagcaau u                                              21


<210> 444
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 444
cugcagaaag ugacaugaun                                                20


<210> 445
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 445
cugcagaaag ugacaugaun n                                              21


<210> 446
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 446
cugcagaaag ugacaugauu u                                              21


<210> 447
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 447
ccccacauau caccaagcan                                                20


<210> 448
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 448
ccccacauau caccaagcan n                                              21


<210> 449
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 449
ccccacauau caccaagcau u                                              21


<210> 450
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 450
cuaccccaca uaucaccaan                                                20


<210> 451
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 451
cuaccccaca uaucaccaan n                                              21


<210> 452
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 452
cuaccccaca uaucaccaau u                                              21


<210> 453
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 453
gcugcagaaa gugacaugan                                                20


<210> 454
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 454
aaaucuaccc cacauaucan                                                20


<210> 455
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 455
aaaucuaccc cacauaucan n                                              21


<210> 456
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 456
aaaucuaccc cacauaucau u                                              21


<210> 457
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 457
aaaaucuacc ccacauaucn                                                20


<210> 458
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 458
aaaaucuacc ccacauaucn n                                              21


<210> 459
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 459
aaaaucuacc ccacauaucu u                                              21


<210> 460
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 460
aaucuacccc acauaucacn                                                20


<210> 461
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 461
aaucuacccc acauaucacn n                                              21


<210> 462
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 462
aaucuacccc acauaucacu u                                              21


<210> 463
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 463
caaaaucuac cccacauaun                                                20


<210> 464
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 464
caaaaucuac cccacauaun n                                              21


<210> 465
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 465
caaaaucuac cccacauauu u                                              21


<210> 466
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 466
aucuacccca cauaucaccn                                                20


<210> 467
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 467
aucuacccca cauaucaccn n                                              21


<210> 468
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 468
aucuacccca cauaucaccu u                                              21


<210> 469
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 469
uuuguccaaa aucuaccccn                                                20


<210> 470
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 470
uuuguccaaa aucuaccccn n                                              21


<210> 471
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 471
uuuguccaaa aucuaccccu u                                              21


<210> 472
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 472
uguccaaaau cuaccccacn                                                20


<210> 473
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 473
uguccaaaau cuaccccacn n                                              21


<210> 474
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 474
uguccaaaau cuaccccacu u                                              21


<210> 475
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 475
uuguccaaaa ucuaccccan                                                20


<210> 476
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 476
uuguccaaaa ucuaccccan n                                              21


<210> 477
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 477
uuguccaaaa ucuaccccau u                                              21


<210> 478
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 478
ucuaccccac auaucaccan                                                20


<210> 479
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 479
ucuaccccac auaucaccan n                                              21


<210> 480
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 480
ucuaccccac auaucaccau u                                              21


<210> 481
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 481
guccaaaauc uaccccacan                                                20


<210> 482
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 482
guccaaaauc uaccccacan n                                              21


<210> 483
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 483
guccaaaauc uaccccacau u                                              21


<210> 484
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 484
uccaaaaucu accccacaun                                                20


<210> 485
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 485
uccaaaaucu accccacaun n                                              21


<210> 486
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 486
uccaaaaucu accccacauu u                                              21


<210> 487
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 487
accccacaua ucaccaagcn                                                20


<210> 488
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 488
accccacaua ucaccaagcn n                                              21


<210> 489
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 489
accccacaua ucaccaagcu u                                              21


<210> 490
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 490
uaccccacau aucaccaagn                                                20


<210> 491
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 491
uaccccacau aucaccaagn n                                              21


<210> 492
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 492
uaccccacau aucaccaagu u                                              21


<210> 493
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 493
ccaaaaucua ccccacauan                                                20


<210> 494
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 494
ccaaaaucua ccccacauan n                                              21


<210> 495
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 495
ccaaaaucua ccccacauau u                                              21


<210> 496
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 496
guacagauuu guccaaaauc                                                20


<210> 497
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 497
uacagauuug uccaaaaucu                                                20


<210> 498
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 498
uacagauuug uccaaaaucu a                                              21


<210> 499
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 499
acagauuugu ccaaaaucua                                                20


<210> 500
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 500
acaucuaugu uugguuucug                                                20


<210> 501
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 501
acagauuugu ccaaaaucua c                                              21


<210> 502
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 502
aguaacaucu auguuugguu                                                20


<210> 503
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 503
guaacaucua uguuugguuu                                                20


<210> 504
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 504
guaacaucua uguuugguuu c                                              21


<210> 505
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 505
uaacaucuau guuugguuuc                                                20


<210> 506
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 506
uaacaucuau guuugguuuc u                                              21


<210> 507
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 507
aacaucuaug uuugguuucu                                                20


<210> 508
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 508
aacaucuaug uuugguuucu g                                              21


<210> 509
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 509
gauuugucca aaaucuaccc                                                20


<210> 510
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 510
gauuugucca aaaucuaccc c                                              21


<210> 511
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 511
agauuugucc aaaaucuacc                                                20


<210> 512
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 512
agauuugucc aaaaucuacc c                                              21


<210> 513
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 513
ugcagaaagu gacaugauuu                                                20


<210> 514
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 514
ccacauauca ccaagcaaau                                                20


<210> 515
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 515
cagauuuguc caaaaucuac                                                20


<210> 516
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 516
cagauuuguc caaaaucuac c                                              21


<210> 517
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 517
auuuguccaa aaucuacccc                                                20


<210> 518
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 518
auuuguccaa aaucuacccc a                                              21


<210> 519
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 519
aaagaccauc caccuccacu                                                20


<210> 520
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 520
cccacauauc accaagcaaa                                                20


<210> 521
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 521
cccacauauc accaagcaaa u                                              21


<210> 522
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 522
cugcagaaag ugacaugauu                                                20


<210> 523
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 523
cugcagaaag ugacaugauu u                                              21


<210> 524
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 524
ccccacauau caccaagcaa                                                20


<210> 525
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 525
ccccacauau caccaagcaa a                                              21


<210> 526
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 526
cuaccccaca uaucaccaag                                                20


<210> 527
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 527
cuaccccaca uaucaccaag c                                              21


<210> 528
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 528
gcugcagaaa gugacaugau                                                20


<210> 529
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 529
aaaucuaccc cacauaucac                                                20


<210> 530
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 530
aaaucuaccc cacauaucac c                                              21


<210> 531
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 531
aaaaucuacc ccacauauca                                                20


<210> 532
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 532
aaaaucuacc ccacauauca c                                              21


<210> 533
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 533
aaucuacccc acauaucacc                                                20


<210> 534
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 534
aaucuacccc acauaucacc a                                              21


<210> 535
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 535
caaaaucuac cccacauauc                                                20


<210> 536
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 536
caaaaucuac cccacauauc a                                              21


<210> 537
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 537
aucuacccca cauaucacca                                                20


<210> 538
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 538
aucuacccca cauaucacca a                                              21


<210> 539
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 539
uuuguccaaa aucuacccca                                                20


<210> 540
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 540
uuuguccaaa aucuacccca c                                              21


<210> 541
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 541
uguccaaaau cuaccccaca                                                20


<210> 542
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 542
uguccaaaau cuaccccaca u                                              21


<210> 543
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 543
uuguccaaaa ucuaccccac                                                20


<210> 544
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 544
uuguccaaaa ucuaccccac a                                              21


<210> 545
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 545
ucuaccccac auaucaccaa                                                20


<210> 546
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 546
ucuaccccac auaucaccaa g                                              21


<210> 547
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 547
guccaaaauc uaccccacau                                                20


<210> 548
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 548
guccaaaauc uaccccacau a                                              21


<210> 549
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 549
uccaaaaucu accccacaua                                                20


<210> 550
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 550
uccaaaaucu accccacaua u                                              21


<210> 551
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 551
accccacaua ucaccaagca                                                20


<210> 552
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 552
accccacaua ucaccaagca a                                              21


<210> 553
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 553
uaccccacau aucaccaagc                                                20


<210> 554
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 554
uaccccacau aucaccaagc a                                              21


<210> 555
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 555
ccaaaaucua ccccacauau                                                20


<210> 556
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA antisense strand

<400> 556
ccaaaaucua ccccacauau c                                              21


<210> 557
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 557
uuuuggacaa aucuguaca                                                 19


<210> 558
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 558
uuuuggacaa aucuguaga                                                 19


<210> 559
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 559
uuuuggacaa aucuguuga                                                 19


<210> 560
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 560
uuuuggacaa aucugauga                                                 19


<210> 561
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 561
uuuuggacaa aucuguaca                                                 19


<210> 562
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 562
uuuuggacaa aucuguaga                                                 19


<210> 563
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 563
uuuuggacaa aucuguuga                                                 19


<210> 564
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 564
uuuuggacaa aucugauga                                                 19


<210> 565
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 565
auuuuggaca aaucuguag                                                 19


<210> 566
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 566
auuuuggaca aaucuguug                                                 19


<210> 567
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 567
auuuuggaca aaucugaug                                                 19


<210> 568
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 568
auuuuggaca aaucucaug                                                 19


<210> 569
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 569
auuuuggaca aaucuguag                                                 19


<210> 570
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 570
auuuuggaca aaucuguug                                                 19


<210> 571
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 571
auuuuggaca aaucugaug                                                 19


<210> 572
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 572
auuuuggaca aaucucaug                                                 19


<210> 573
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 573
gauuuuggac aaaucuguu                                                 19


<210> 574
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 574
gauuuuggac aaaucugau                                                 19


<210> 575
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 575
gauuuuggac aaaucucau                                                 19


<210> 576
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 576
gauuuuggac aaaucacau                                                 19


<210> 577
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 577
gauuuuggac aaaucuguu                                                 19


<210> 578
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 578
gauuuuggac aaaucugau                                                 19


<210> 579
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 579
gauuuuggac aaaucucau                                                 19


<210> 580
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 580
gauuuuggac aaaucacau                                                 19


<210> 581
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 581
agauuuugga caaaucuga                                                 19


<210> 582
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 582
agauuuugga caaaucuca                                                 19


<210> 583
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 583
agauuuugga caaaucaca                                                 19


<210> 584
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 584
agauuuugga caaaugaca                                                 19


<210> 585
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 585
agauuuugga caaaucuga                                                 19


<210> 586
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 586
agauuuugga caaaucuca                                                 19


<210> 587
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 587
agauuuugga caaaucaca                                                 19


<210> 588
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 588
agauuuugga caaaugaca                                                 19


<210> 589
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 589
accaaacaua gauguuaca                                                 19


<210> 590
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 590
accaaacaua gauguuaga                                                 19


<210> 591
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 591
accaaacaua gauguuuga                                                 19


<210> 592
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 592
accaaacaua gauguauga                                                 19


<210> 593
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 593
accaaacaua gauguuaca                                                 19


<210> 594
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 594
accaaacaua gauguuaga                                                 19


<210> 595
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 595
accaaacaua gauguuuga                                                 19


<210> 596
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 596
accaaacaua gauguauga                                                 19


<210> 597
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 597
aaccaaacau agauguuag                                                 19


<210> 598
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 598
aaccaaacau agauguuug                                                 19


<210> 599
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 599
aaccaaacau agauguaug                                                 19


<210> 600
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 600
aaccaaacau agaugaaug                                                 19


<210> 601
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 601
aaccaaacau agauguuag                                                 19


<210> 602
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 602
aaccaaacau agauguuug                                                 19


<210> 603
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 603
aaccaaacau agauguaug                                                 19


<210> 604
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 604
aaccaaacau agaugaaug                                                 19


<210> 605
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 605
aaaccaaaca uagauguuu                                                 19


<210> 606
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 606
aaaccaaaca uagauguau                                                 19


<210> 607
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 607
aaaccaaaca uagaugaau                                                 19


<210> 608
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 608
aaaccaaaca uagaucaau                                                 19


<210> 609
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 609
aaaccaaaca uagauguuu                                                 19


<210> 610
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 610
aaaccaaaca uagauguau                                                 19


<210> 611
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 611
aaaccaaaca uagaugaau                                                 19


<210> 612
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 612
aaaccaaaca uagaucaau                                                 19


<210> 613
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 613
gaaaccaaac auagaugua                                                 19


<210> 614
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 614
gaaaccaaac auagaugaa                                                 19


<210> 615
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 615
gaaaccaaac auagaucaa                                                 19


<210> 616
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 616
gaaaccaaac auagaacaa                                                 19


<210> 617
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 617
gaaaccaaac auagaugua                                                 19


<210> 618
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 618
gaaaccaaac auagaugaa                                                 19


<210> 619
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 619
gaaaccaaac auagaucaa                                                 19


<210> 620
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 620
gaaaccaaac auagaacaa                                                 19


<210> 621
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 621
ccaaacauag auguuacuc                                                 19


<210> 622
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 622
ccaaacauag auguuacac                                                 19


<210> 623
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 623
ccaaacauag auguuagac                                                 19


<210> 624
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 624
ccaaacauag auguuugac                                                 19


<210> 625
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 625
ccaaacauag auguuacuc                                                 19


<210> 626
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 626
ccaaacauag auguuacac                                                 19


<210> 627
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 627
ccaaacauag auguuagac                                                 19


<210> 628
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 628
ccaaacauag auguuugac                                                 19


<210> 629
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 629
gguagauuuu ggacaaaug                                                 19


<210> 630
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 630
gguagauuuu ggacaaaag                                                 19


<210> 631
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 631
gguagauuuu ggacaauag                                                 19


<210> 632
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 632
gguagauuuu ggacauuag                                                 19


<210> 633
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 633
gguagauuuu ggacaaaug                                                 19


<210> 634
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 634
gguagauuuu ggacaaaag                                                 19


<210> 635
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 635
gguagauuuu ggacaauag                                                 19


<210> 636
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 636
gguagauuuu ggacauuag                                                 19


<210> 637
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 637
guagauuuug gacaaauca                                                 19


<210> 638
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 638
guagauuuug gacaaauga                                                 19


<210> 639
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 639
guagauuuug gacaaaaga                                                 19


<210> 640
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 640
guagauuuug gacaauaga                                                 19


<210> 641
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 641
guagauuuug gacaaauca                                                 19


<210> 642
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 642
guagauuuug gacaaauga                                                 19


<210> 643
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 643
guagauuuug gacaaaaga                                                 19


<210> 644
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 644
guagauuuug gacaauaga                                                 19


<210> 645
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 645
uggaggugga uggucuuuu                                                 19


<210> 646
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 646
uggaggugga uggucuuau                                                 19


<210> 647
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 647
uggaggugga uggucuaau                                                 19


<210> 648
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 648
uggaggugga uggucaaau                                                 19


<210> 649
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 649
uggaggugga uggucuuuu                                                 19


<210> 650
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 650
uggaggugga uggucuuau                                                 19


<210> 651
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 651
uggaggugga uggucuaau                                                 19


<210> 652
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 652
uggaggugga uggucaaau                                                 19


<210> 653
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 653
uagauuuugg acaaaucuc                                                 19


<210> 654
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 654
uagauuuugg acaaaucac                                                 19


<210> 655
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 655
uagauuuugg acaaaugac                                                 19


<210> 656
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 656
uagauuuugg acaaaagac                                                 19


<210> 657
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 657
uagauuuugg acaaaucuc                                                 19


<210> 658
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 658
uagauuuugg acaaaucac                                                 19


<210> 659
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 659
uagauuuugg acaaaugac                                                 19


<210> 660
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 660
uagauuuugg acaaaagac                                                 19


<210> 661
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 661
ggguagauuu uggacaaaa                                                 19


<210> 662
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 662
ggguagauuu uggacaaua                                                 19


<210> 663
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 663
ggguagauuu uggacauua                                                 19


<210> 664
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 664
ggguagauuu uggacuuua                                                 19


<210> 665
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 665
ggguagauuu uggacaaaa                                                 19


<210> 666
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 666
ggguagauuu uggacaaua                                                 19


<210> 667
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 667
ggguagauuu uggacauua                                                 19


<210> 668
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 668
ggguagauuu uggacuuua                                                 19


<210> 669
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 669
uugcuuggug auauguggc                                                 19


<210> 670
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 670
uugcuuggug auaugugcc                                                 19


<210> 671
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 671
uugcuuggug auauguccc                                                 19


<210> 672
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 672
uugcuuggug auaugaccc                                                 19


<210> 673
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 673
uugcuuggug auauguggc                                                 19


<210> 674
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 674
uugcuuggug auaugugcc                                                 19


<210> 675
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 675
uugcuuggug auauguccc                                                 19


<210> 676
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 676
uugcuuggug auaugaccc                                                 19


<210> 677
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 677
aucaugucac uuucugcac                                                 19


<210> 678
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 678
aucaugucac uuucugcuc                                                 19


<210> 679
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 679
aucaugucac uuucugguc                                                 19


<210> 680
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 680
aucaugucac uuucucguc                                                 19


<210> 681
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 681
aucaugucac uuucugcac                                                 19


<210> 682
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 682
aucaugucac uuucugcuc                                                 19


<210> 683
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 683
aucaugucac uuucugguc                                                 19


<210> 684
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 684
aucaugucac uuucucguc                                                 19


<210> 685
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 685
ugcuugguga uaugugggc                                                 19


<210> 686
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 686
ugcuugguga uauguggcc                                                 19


<210> 687
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 687
ugcuugguga uaugugccc                                                 19


<210> 688
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 688
ugcuugguga uaugucccc                                                 19


<210> 689
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 689
ugcuugguga uaugugggc                                                 19


<210> 690
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 690
ugcuugguga uauguggcc                                                 19


<210> 691
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 691
ugcuugguga uaugugccc                                                 19


<210> 692
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 692
ugcuugguga uaugucccc                                                 19


<210> 693
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 693
uuggugauau gugggguac                                                 19


<210> 694
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 694
uuggugauau gugggguuc                                                 19


<210> 695
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 695
uuggugauau guggggauc                                                 19


<210> 696
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 696
uuggugauau gugggcauc                                                 19


<210> 697
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 697
uuggugauau gugggguac                                                 19


<210> 698
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 698
uuggugauau gugggguuc                                                 19


<210> 699
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 699
uuggugauau guggggauc                                                 19


<210> 700
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 700
uuggugauau gugggcauc                                                 19


<210> 701
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 701
ucaugucacu uucugcagg                                                 19


<210> 702
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 702
ucaugucacu uucugcacg                                                 19


<210> 703
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 703
ucaugucacu uucugcucg                                                 19


<210> 704
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 704
ucaugucacu uucuggucg                                                 19


<210> 705
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 705
ucaugucacu uucugcagg                                                 19


<210> 706
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 706
ucaugucacu uucugcacg                                                 19


<210> 707
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 707
ucaugucacu uucugcucg                                                 19


<210> 708
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 708
ucaugucacu uucuggucg                                                 19


<210> 709
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 709
caugucacuu ucugcagcg                                                 19


<210> 710
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 710
caugucacuu ucugcaggg                                                 19


<210> 711
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 711
caugucacuu ucugcacgg                                                 19


<210> 712
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 712
caugucacuu ucugcucgg                                                 19


<210> 713
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 713
caugucacuu ucugcagcg                                                 19


<210> 714
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 714
caugucacuu ucugcaggg                                                 19


<210> 715
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 715
caugucacuu ucugcacgg                                                 19


<210> 716
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 716
caugucacuu ucugcucgg                                                 19


<210> 717
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 717
ugauaugugg gguagauua                                                 19


<210> 718
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 718
ugauaugugg gguagauaa                                                 19


<210> 719
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 719
ugauaugugg gguagaaaa                                                 19


<210> 720
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 720
ugauaugugg gguaguaaa                                                 19


<210> 721
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 721
ugauaugugg gguagauua                                                 19


<210> 722
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 722
ugauaugugg gguagauaa                                                 19


<210> 723
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 723
ugauaugugg gguagaaaa                                                 19


<210> 724
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 724
ugauaugugg gguaguaaa                                                 19


<210> 725
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 725
gauauguggg guagauuua                                                 19


<210> 726
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 726
gauauguggg guagauuaa                                                 19


<210> 727
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 727
gauauguggg guagauaaa                                                 19


<210> 728
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 728
gauauguggg guagaaaaa                                                 19


<210> 729
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 729
gauauguggg guagauuua                                                 19


<210> 730
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 730
gauauguggg guagauuaa                                                 19


<210> 731
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 731
gauauguggg guagauaaa                                                 19


<210> 732
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 732
gauauguggg guagaaaaa                                                 19


<210> 733
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 733
gugauaugug ggguagaua                                                 19


<210> 734
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 734
gugauaugug ggguagaaa                                                 19


<210> 735
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 735
gugauaugug ggguaguaa                                                 19


<210> 736
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 736
gugauaugug ggguacuaa                                                 19


<210> 737
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 737
gugauaugug ggguagaua                                                 19


<210> 738
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 738
gugauaugug ggguagaaa                                                 19


<210> 739
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 739
gugauaugug ggguaguaa                                                 19


<210> 740
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 740
gugauaugug ggguacuaa                                                 19


<210> 741
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 741
auaugugggg uagauuuuc                                                 19


<210> 742
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 742
auaugugggg uagauuuac                                                 19


<210> 743
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 743
auaugugggg uagauuaac                                                 19


<210> 744
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 744
auaugugggg uagauaaac                                                 19


<210> 745
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 745
auaugugggg uagauuuuc                                                 19


<210> 746
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 746
auaugugggg uagauuuac                                                 19


<210> 747
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 747
auaugugggg uagauuaac                                                 19


<210> 748
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 748
auaugugggg uagauaaac                                                 19


<210> 749
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 749
ggugauaugu gggguagaa                                                 19


<210> 750
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 750
ggugauaugu gggguagua                                                 19


<210> 751
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 751
ggugauaugu gggguacua                                                 19


<210> 752
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 752
ggugauaugu gggguucua                                                 19


<210> 753
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 753
ggugauaugu gggguagaa                                                 19


<210> 754
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 754
ggugauaugu gggguagua                                                 19


<210> 755
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 755
ggugauaugu gggguacua                                                 19


<210> 756
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 756
ggugauaugu gggguucua                                                 19


<210> 757
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 757
gggguagauu uuggacaau                                                 19


<210> 758
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 758
gggguagauu uuggacauu                                                 19


<210> 759
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 759
gggguagauu uuggacuuu                                                 19


<210> 760
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 760
gggguagauu uuggaguuu                                                 19


<210> 761
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 761
gggguagauu uuggacaau                                                 19


<210> 762
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 762
gggguagauu uuggacauu                                                 19


<210> 763
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 763
gggguagauu uuggacuuu                                                 19


<210> 764
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 764
gggguagauu uuggaguuu                                                 19


<210> 765
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 765
gugggguaga uuuuggacu                                                 19


<210> 766
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 766
gugggguaga uuuuggagu                                                 19


<210> 767
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 767
gugggguaga uuuuggugu                                                 19


<210> 768
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 768
gugggguaga uuuugcugu                                                 19


<210> 769
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 769
gugggguaga uuuuggacu                                                 19


<210> 770
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 770
gugggguaga uuuuggagu                                                 19


<210> 771
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 771
gugggguaga uuuuggugu                                                 19


<210> 772
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 772
gugggguaga uuuugcugu                                                 19


<210> 773
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 773
ugggguagau uuuggacau                                                 19


<210> 774
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 774
ugggguagau uuuggacuu                                                 19


<210> 775
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 775
ugggguagau uuuggaguu                                                 19


<210> 776
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 776
ugggguagau uuugguguu                                                 19


<210> 777
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 777
ugggguagau uuuggacau                                                 19


<210> 778
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 778
ugggguagau uuuggacuu                                                 19


<210> 779
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 779
ugggguagau uuuggaguu                                                 19


<210> 780
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 780
ugggguagau uuugguguu                                                 19


<210> 781
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 781
uggugauaug ugggguagu                                                 19


<210> 782
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 782
uggugauaug ugggguacu                                                 19


<210> 783
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 783
uggugauaug ugggguucu                                                 19


<210> 784
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 784
uggugauaug uggggaucu                                                 19


<210> 785
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 785
uggugauaug ugggguagu                                                 19


<210> 786
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 786
uggugauaug ugggguacu                                                 19


<210> 787
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 787
uggugauaug ugggguucu                                                 19


<210> 788
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 788
uggugauaug uggggaucu                                                 19


<210> 789
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 789
ugugggguag auuuuggag                                                 19


<210> 790
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 790
ugugggguag auuuuggug                                                 19


<210> 791
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 791
ugugggguag auuuugcug                                                 19


<210> 792
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 792
ugugggguag auuuuccug                                                 19


<210> 793
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 793
ugugggguag auuuuggag                                                 19


<210> 794
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 794
ugugggguag auuuuggug                                                 19


<210> 795
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 795
ugugggguag auuuugcug                                                 19


<210> 796
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 796
ugugggguag auuuuccug                                                 19


<210> 797
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 797
auguggggua gauuuuggu                                                 19


<210> 798
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 798
auguggggua gauuuugcu                                                 19


<210> 799
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 799
auguggggua gauuuuccu                                                 19


<210> 800
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 800
auguggggua gauuuaccu                                                 19


<210> 801
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 801
auguggggua gauuuuggu                                                 19


<210> 802
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 802
auguggggua gauuuugcu                                                 19


<210> 803
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 803
auguggggua gauuuuccu                                                 19


<210> 804
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 804
auguggggua gauuuaccu                                                 19


<210> 805
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 805
gcuuggugau augugggga                                                 19


<210> 806
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 806
gcuuggugau augugggca                                                 19


<210> 807
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 807
gcuuggugau auguggcca                                                 19


<210> 808
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 808
gcuuggugau augugccca                                                 19


<210> 809
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 809
gcuuggugau augugggga                                                 19


<210> 810
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 810
gcuuggugau augugggca                                                 19


<210> 811
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 811
gcuuggugau auguggcca                                                 19


<210> 812
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 812
gcuuggugau augugccca                                                 19


<210> 813
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 813
cuuggugaua ugugggguu                                                 19


<210> 814
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 814
cuuggugaua uguggggau                                                 19


<210> 815
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 815
cuuggugaua ugugggcau                                                 19


<210> 816
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 816
cuuggugaua uguggccau                                                 19


<210> 817
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 817
cuuggugaua ugugggguu                                                 19


<210> 818
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 818
cuuggugaua uguggggau                                                 19


<210> 819
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 819
cuuggugaua ugugggcau                                                 19


<210> 820
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 820
cuuggugaua uguggccau                                                 19


<210> 821
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 821
uauguggggu agauuuugc                                                 19


<210> 822
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 822
uauguggggu agauuuucc                                                 19


<210> 823
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 823
uauguggggu agauuuacc                                                 19


<210> 824
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 824
uauguggggu agauuaacc                                                 19


<210> 825
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 825
uauguggggu agauuuugc                                                 19


<210> 826
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 826
uauguggggu agauuuucc                                                 19


<210> 827
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 827
uauguggggu agauuuacc                                                 19


<210> 828
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 828
uauguggggu agauuaacc                                                 19


<210> 829
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 829
auuuuggaca aaucuguacn                                                20


<210> 830
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 830
gauuuuggac aaaucuguan                                                20


<210> 831
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 831
gauuuuggac aaaucuguan n                                              21


<210> 832
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 832
gauuuuggac aaaucuguau u                                              21


<210> 833
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 833
agauuuugga caaaucugun                                                20


<210> 834
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 834
agauuuugga caaaucugun n                                              21


<210> 835
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 835
agauuuugga caaaucuguu u                                              21


<210> 836
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 836
agaaaccaaa cauagaugun                                                20


<210> 837
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 837
accaaacaua gauguuacun                                                20


<210> 838
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 838
aaccaaacau agauguuacn                                                20


<210> 839
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 839
aaccaaacau agauguuacn n                                              21


<210> 840
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 840
aaccaaacau agauguuacu u                                              21


<210> 841
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 841
aaaccaaaca uagauguuan                                                20


<210> 842
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 842
aaaccaaaca uagauguuan n                                              21


<210> 843
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 843
aaaccaaaca uagauguuau u                                              21


<210> 844
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 844
gaaaccaaac auagauguun                                                20


<210> 845
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 845
gaaaccaaac auagauguun n                                              21


<210> 846
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 846
gaaaccaaac auagauguuu u                                              21


<210> 847
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 847
gguagauuuu ggacaaaucn                                                20


<210> 848
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 848
gguagauuuu ggacaaaucn n                                              21


<210> 849
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 849
gguagauuuu ggacaaaucu u                                              21


<210> 850
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 850
guagauuuug gacaaaucun                                                20


<210> 851
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 851
guagauuuug gacaaaucun n                                              21


<210> 852
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 852
guagauuuug gacaaaucuu u                                              21


<210> 853
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 853
aaucauguca cuuucugcan                                                20


<210> 854
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 854
uuugcuuggu gauauguggn                                                20


<210> 855
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 855
uagauuuugg acaaaucugn                                                20


<210> 856
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 856
uagauuuugg acaaaucugn n                                              21


<210> 857
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 857
uagauuuugg acaaaucugu u                                              21


<210> 858
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 858
ggguagauuu uggacaaaun                                                20


<210> 859
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 859
ggguagauuu uggacaaaun n                                              21


<210> 860
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 860
ggguagauuu uggacaaauu u                                              21


<210> 861
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 861
guggaggugg auggucuuun                                                20


<210> 862
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 862
uugcuuggug auaugugggn                                                20


<210> 863
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 863
uugcuuggug auaugugggn n                                              21


<210> 864
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 864
uugcuuggug auaugugggu u                                              21


<210> 865
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 865
aucaugucac uuucugcagn                                                20


<210> 866
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 866
aucaugucac uuucugcagn n                                              21


<210> 867
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 867
aucaugucac uuucugcagu u                                              21


<210> 868
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 868
ugcuugguga uauguggggn                                                20


<210> 869
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 869
ugcuugguga uauguggggn n                                              21


<210> 870
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 870
ugcuugguga uauguggggu u                                              21


<210> 871
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 871
uuggugauau gugggguagn                                                20


<210> 872
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 872
uuggugauau gugggguagn n                                              21


<210> 873
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 873
uuggugauau gugggguagu u                                              21


<210> 874
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 874
ucaugucacu uucugcagcn                                                20


<210> 875
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 875
ugauaugugg gguagauuun                                                20


<210> 876
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 876
ugauaugugg gguagauuun n                                              21


<210> 877
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 877
ugauaugugg gguagauuuu u                                              21


<210> 878
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 878
gauauguggg guagauuuun                                                20


<210> 879
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 879
gauauguggg guagauuuun n                                              21


<210> 880
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 880
gauauguggg guagauuuuu u                                              21


<210> 881
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 881
gugauaugug ggguagauun                                                20


<210> 882
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 882
gugauaugug ggguagauun n                                              21


<210> 883
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 883
gugauaugug ggguagauuu u                                              21


<210> 884
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 884
auaugugggg uagauuuugn                                                20


<210> 885
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 885
auaugugggg uagauuuugn n                                              21


<210> 886
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 886
auaugugggg uagauuuugu u                                              21


<210> 887
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 887
ggugauaugu gggguagaun                                                20


<210> 888
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 888
ggugauaugu gggguagaun n                                              21


<210> 889
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 889
ggugauaugu gggguagauu u                                              21


<210> 890
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 890
gggguagauu uuggacaaan                                                20


<210> 891
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 891
gggguagauu uuggacaaan n                                              21


<210> 892
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 892
gggguagauu uuggacaaau u                                              21


<210> 893
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 893
gugggguaga uuuuggacan                                                20


<210> 894
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 894
gugggguaga uuuuggacan n                                              21


<210> 895
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 895
gugggguaga uuuuggacau u                                              21


<210> 896
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 896
ugggguagau uuuggacaan                                                20


<210> 897
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 897
ugggguagau uuuggacaan n                                              21


<210> 898
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 898
ugggguagau uuuggacaau u                                              21


<210> 899
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 899
uggugauaug ugggguagan                                                20


<210> 900
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 900
uggugauaug ugggguagan n                                              21


<210> 901
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 901
uggugauaug ugggguagau u                                              21


<210> 902
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 902
ugugggguag auuuuggacn                                                20


<210> 903
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 903
ugugggguag auuuuggacn n                                              21


<210> 904
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 904
ugugggguag auuuuggacu u                                              21


<210> 905
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 905
auguggggua gauuuuggan                                                20


<210> 906
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 906
auguggggua gauuuuggan n                                              21


<210> 907
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 907
auguggggua gauuuuggau u                                              21


<210> 908
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 908
gcuuggugau auguggggun                                                20


<210> 909
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 909
gcuuggugau auguggggun n                                              21


<210> 910
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 910
gcuuggugau augugggguu u                                              21


<210> 911
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 911
cuuggugaua ugugggguan                                                20


<210> 912
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 912
cuuggugaua ugugggguan n                                              21


<210> 913
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 913
cuuggugaua ugugggguau u                                              21


<210> 914
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 914
uauguggggu agauuuuggn                                                20


<210> 915
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<220> 
<221> misc_feature
<222> 20
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<220> 
<221> misc_feature
<222> 21
<223> /note="n is dT (deoxythymine or 2'H thymine)"

<400> 915
uauguggggu agauuuuggn n                                              21


<210> 916
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 916
uauguggggu agauuuuggu u                                              21


<210> 917
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 917
auuuuggaca aaucuguacu                                                20


<210> 918
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 918
gauuuuggac aaaucuguac                                                20


<210> 919
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 919
gauuuuggac aaaucuguac u                                              21


<210> 920
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 920
agauuuugga caaaucugua                                                20


<210> 921
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 921
agaaaccaaa cauagauguu                                                20


<210> 922
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 922
agauuuugga caaaucugua c                                              21


<210> 923
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 923
accaaacaua gauguuacug                                                20


<210> 924
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 924
aaccaaacau agauguuacu                                                20


<210> 925
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 925
aaccaaacau agauguuacu g                                              21


<210> 926
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 926
aaaccaaaca uagauguuac                                                20


<210> 927
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 927
aaaccaaaca uagauguuac u                                              21


<210> 928
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 928
gaaaccaaac auagauguua                                                20


<210> 929
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 929
gaaaccaaac auagauguua c                                              21


<210> 930
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 930
gguagauuuu ggacaaaucu                                                20


<210> 931
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 931
gguagauuuu ggacaaaucu g                                              21


<210> 932
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 932
guagauuuug gacaaaucug                                                20


<210> 933
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 933
guagauuuug gacaaaucug u                                              21


<210> 934
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 934
aaucauguca cuuucugcag                                                20


<210> 935
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 935
uuugcuuggu gauauguggg                                                20


<210> 936
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 936
uagauuuugg acaaaucugu                                                20


<210> 937
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 937
uagauuuugg acaaaucugu a                                              21


<210> 938
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 938
ggguagauuu uggacaaauc                                                20


<210> 939
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 939
ggguagauuu uggacaaauc u                                              21


<210> 940
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 940
guggaggugg auggucuuua                                                20


<210> 941
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 941
uugcuuggug auaugugggg                                                20


<210> 942
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 942
uugcuuggug auaugugggg u                                              21


<210> 943
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 943
aucaugucac uuucugcagc                                                20


<210> 944
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 944
aucaugucac uuucugcagc c                                              21


<210> 945
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 945
ugcuugguga uauguggggu                                                20


<210> 946
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 946
ugcuugguga uauguggggu a                                              21


<210> 947
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 947
uuggugauau gugggguaga                                                20


<210> 948
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 948
uuggugauau gugggguaga u                                              21


<210> 949
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 949
ucaugucacu uucugcagcc                                                20


<210> 950
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 950
ugauaugugg gguagauuuu                                                20


<210> 951
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 951
ugauaugugg gguagauuuu g                                              21


<210> 952
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 952
gauauguggg guagauuuug                                                20


<210> 953
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 953
gauauguggg guagauuuug g                                              21


<210> 954
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 954
gugauaugug ggguagauuu                                                20


<210> 955
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 955
gugauaugug ggguagauuu u                                              21


<210> 956
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 956
auaugugggg uagauuuugg                                                20


<210> 957
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 957
auaugugggg uagauuuugg a                                              21


<210> 958
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 958
ggugauaugu gggguagauu                                                20


<210> 959
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 959
ggugauaugu gggguagauu u                                              21


<210> 960
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 960
gggguagauu uuggacaaau                                                20


<210> 961
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 961
gggguagauu uuggacaaau c                                              21


<210> 962
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 962
gugggguaga uuuuggacaa                                                20


<210> 963
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 963
gugggguaga uuuuggacaa a                                              21


<210> 964
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 964
ugggguagau uuuggacaaa                                                20


<210> 965
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 965
ugggguagau uuuggacaaa u                                              21


<210> 966
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 966
uggugauaug ugggguagau                                                20


<210> 967
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 967
uggugauaug ugggguagau u                                              21


<210> 968
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 968
ugugggguag auuuuggaca                                                20


<210> 969
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 969
ugugggguag auuuuggaca a                                              21


<210> 970
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 970
auguggggua gauuuuggac                                                20


<210> 971
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 971
auguggggua gauuuuggac a                                              21


<210> 972
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 972
gcuuggugau auguggggua                                                20


<210> 973
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 973
gcuuggugau auguggggua g                                              21


<210> 974
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 974
cuuggugaua ugugggguag                                                20


<210> 975
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 975
cuuggugaua ugugggguag a                                              21


<210> 976
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 976
uauguggggu agauuuugga                                                20


<210> 977
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> ACE2 siRNA sense strand

<400> 977
uauguggggu agauuuugga c                                              21


<210> 978
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 978
aguacagauu uguccaaaa                                                 19


<210> 979
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<400> 979
aguacagauu uguccaaaa                                                 19


<210> 980
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 980
guacagauuu guccaaaau                                                 19


<210> 981
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 981
guacagauuu guccaaaau                                                 19


<210> 982
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 982
uacagauuug uccaaaauc                                                 19


<210> 983
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 983
uacagauuug uccaaaauc                                                 19


<210> 984
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 984
acaucuaugu uugguuucu                                                 19


<210> 985
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 985
acaucuaugu uugguuucu                                                 19


<210> 986
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 986
acagauuugu ccaaaaucu                                                 19


<210> 987
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 987
acagauuugu ccaaaaucu                                                 19


<210> 988
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 988
aguaacaucu auguuuggu                                                 19


<210> 989
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 989
aguaacaucu auguuuggu                                                 19


<210> 990
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 990
cacauaucac caagcaaau                                                 19


<210> 991
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 991
cacauaucac caagcaaau                                                 19


<210> 992
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 992
uaacaucuau guuugguuu                                                 19


<210> 993
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 993
uaacaucuau guuugguuu                                                 19


<210> 994
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 994
aacaucuaug uuugguuuc                                                 19


<210> 995
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 995
aacaucuaug uuugguuuc                                                 19


<210> 996
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 996
caucuauguu ugguuucug                                                 19


<210> 997
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<400> 997
caucuauguu ugguuucug                                                 19


<210> 998
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 998
caguaacauc uauguuugg                                                 19


<210> 999
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<400> 999
caguaacauc uauguuugg                                                 19


<210> 1000
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1000
gauuugucca aaaucuacc                                                 19


<210> 1001
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 1001
gauuugucca aaaucuacc                                                 19


<210> 1002
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1002
agauuugucc aaaaucuac                                                 19


<210> 1003
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 1003
agauuugucc aaaaucuac                                                 19


<210> 1004
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 1004
ccacauauca ccaagcaaa                                                 19


<210> 1005
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<400> 1005
ccacauauca ccaagcaaa                                                 19


<210> 1006
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1006
guaacaucua uguuugguu                                                 19


<210> 1007
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA antisense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1007
guaacaucua uguuugguu                                                 19


<210> 1008
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1008
uuuuggacaa aucuguacu                                                 19


<210> 1009
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<400> 1009
uuuuggacaa aucuguacu                                                 19


<210> 1010
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 1010
auuuuggaca aaucuguac                                                 19


<210> 1011
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<400> 1011
auuuuggaca aaucuguac                                                 19


<210> 1012
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1012
gauuuuggac aaaucugua                                                 19


<210> 1013
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<400> 1013
gauuuuggac aaaucugua                                                 19


<210> 1014
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1014
agaaaccaaa cauagaugu                                                 19


<210> 1015
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<400> 1015
agaaaccaaa cauagaugu                                                 19


<210> 1016
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1016
agauuuugga caaaucugu                                                 19


<210> 1017
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<400> 1017
agauuuugga caaaucugu                                                 19


<210> 1018
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1018
accaaacaua gauguuacu                                                 19


<210> 1019
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<400> 1019
accaaacaua gauguuacu                                                 19


<210> 1020
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1020
auuugcuugg ugauaugug                                                 19


<210> 1021
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<400> 1021
auuugcuugg ugauaugug                                                 19


<210> 1022
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1022
aaaccaaaca uagauguua                                                 19


<210> 1023
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<400> 1023
aaaccaaaca uagauguua                                                 19


<210> 1024
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1024
gaaaccaaac auagauguu                                                 19


<210> 1025
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<400> 1025
gaaaccaaac auagauguu                                                 19


<210> 1026
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1026
cagaaaccaa acauagaug                                                 19


<210> 1027
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<400> 1027
cagaaaccaa acauagaug                                                 19


<210> 1028
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1028
ccaaacauag auguuacug                                                 19


<210> 1029
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<400> 1029
ccaaacauag auguuacug                                                 19


<210> 1030
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 1030
gguagauuuu ggacaaauc                                                 19


<210> 1031
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<400> 1031
gguagauuuu ggacaaauc                                                 19


<210> 1032
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1032
guagauuuug gacaaaucu                                                 19


<210> 1033
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<400> 1033
guagauuuug gacaaaucu                                                 19


<210> 1034
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<400> 1034
uuugcuuggu gauaugugg                                                 19


<210> 1035
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<400> 1035
uuugcuuggu gauaugugg                                                 19


<210> 1036
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<400> 1036
aaccaaacau agauguuac                                                 19


<210> 1037
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Modified ACE2 siRNA sense strand

<220> 
<221> modified_base
<222> 1
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 2
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 3
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<220> 
<221> modified_base
<222> 4
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 5
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 6
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 7
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 8
<223> /mod_base=OTHER
      /note="2'-O-methylcytidine"

<220> 
<221> modified_base
<222> 9
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 10
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 11
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 12
<223> /mod_base=OTHER
      /note="2'-O-methylguanosine"

<220> 
<221> modified_base
<222> 13
<223> /mod_base=OTHER
      /note="2'-fluoroadenosine"

<220> 
<221> modified_base
<222> 14
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 15
<223> /mod_base=OTHER
      /note="2'-fluoroguanosine"

<220> 
<221> modified_base
<222> 16
<223> /mod_base=OTHER
      /note="2'-O-methyluridine"

<220> 
<221> modified_base
<222> 17
<223> /mod_base=OTHER
      /note="2'-fluorouridine"

<220> 
<221> modified_base
<222> 18
<223> /mod_base=OTHER
      /note="2'-O-methyladenosine"

<220> 
<221> modified_base
<222> 19
<223> /mod_base=OTHER
      /note="2'-fluorocytidine"

<400> 1037
aaccaaacau agauguuac                                                 19


<210> 1038
<211> 45
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA antisense strands

<400> 1038
aguacagauu uguccaaaau cuaccccaca uaucaccaag caaau                     45


<210> 1039
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA antisense strands

<400> 1039
caguaacauc uauguuuggu uucug                                          25


<210> 1040
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA antisense strands

<400> 1040
ggcugcagaa agugacauga uuu                                            23


<210> 1041
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA antisense strands

<400> 1041
uaaagaccau ccaccuccac u                                              21


<210> 1042
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA antisense strands

<400> 1042
aaugaaugag uaaucauua                                                 19


<210> 1043
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA antisense strands

<400> 1043
ugcuucuuga aacuggaauu                                                20


<210> 1044
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA antisense strands

<400> 1044
aguacagauu uguccaaaau cuac                                           24


<210> 1045
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA antisense strands

<400> 1045
cacauaucac caagcaaau                                                 19


<210> 1046
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA antisense strands

<400> 1046
agauuugucc aaaaucuacc cc                                             22


<210> 1047
<211> 24
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA antisense strands

<400> 1047
aguaacaucu auguuugguu ucug                                           24


<210> 1048
<211> 45
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA sense strands

<400> 1048
auuugcuugg ugauaugugg gguagauuuu ggacaaaucu guacu                     45


<210> 1049
<211> 25
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA sense strands

<400> 1049
cagaaaccaa acauagaugu uacug                                          25


<210> 1050
<211> 23
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA sense strands

<400> 1050
aaaucauguc acuuucugca gcc                                            23


<210> 1051
<211> 21
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA sense strands

<400> 1051
aguggaggug gauggucuuu a                                              21


<210> 1052
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA sense strands

<400> 1052
uaaugauuac ucauucauu                                                 19


<210> 1053
<211> 20
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA sense strands

<400> 1053
aauuccaguu ucaagaagca                                                20


<210> 1054
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA sense strands

<400> 1054
agauuuugga caaaucugua cu                                             22


<210> 1055
<211> 19
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA sense strands

<400> 1055
auuugcuugg ugauaugug                                                 19


<210> 1056
<211> 22
<212> RNA
<213> Artificial Sequence


<220> 
<223> Common region for siRNA sense strands

<400> 1056
gguagauuuu ggacaaaucu gu                                             22


