                         SEQUENCE LISTING

<110>  Aarhus Universitet
 
<120>  A drug screening platform for endosomal enhancers to treat 
       Alzheimer's disease

<130>  P5628PC00

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  2641
<212>  PRT
<213>  Artificial

<220>
<223>  sorLA-reporter construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2641)
<223>  sorLA-reporter construct

<400>  1

Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu 
            20                  25                  30          


Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr 
        35                  40                  45              


Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser 
    50                  55                  60                  


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu 
65                  70                  75                  80  


Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu 
                85                  90                  95      


Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr 
            100                 105                 110         


Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly 
        115                 120                 125             


Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn 
    130                 135                 140                 


Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val 
145                 150                 155                 160 


Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr 
                165                 170                 175     


Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro 
            180                 185                 190         


Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile 
        195                 200                 205             


Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met 
    210                 215                 220                 


Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln 
225                 230                 235                 240 


Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala 
                245                 250                 255     


Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln 
            260                 265                 270         


Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro 
        275                 280                 285             


Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser 
    290                 295                 300                 


Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro 
305                 310                 315                 320 


Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His 
                325                 330                 335     


His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp 
            340                 345                 350         


Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu 
        355                 360                 365             


Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr 
    370                 375                 380                 


Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg 
385                 390                 395                 400 


Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr 
                405                 410                 415     


Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly 
            420                 425                 430         


Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr 
        435                 440                 445             


His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His 
    450                 455                 460                 


Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala 
465                 470                 475                 480 


Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro 
                485                 490                 495     


Ala Gly Thr Thr Asp Ala Ala His Pro Gly Leu Glu Ser Ala Ala Leu 
            500                 505                 510         


Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val Ser Leu Asn Asp Ser 
        515                 520                 525             


His Asn Gln Met Val Val His Trp Ala Gly Glu Lys Ser Asn Val Ile 
    530                 535                 540                 


Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala Arg Pro Lys Ser Ser 
545                 550                 555                 560 


Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser Phe Lys Lys Ile Ser 
                565                 570                 575     


Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser Glu Ala Val Ile Ala 
            580                 585                 590         


Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg Tyr Ile Phe Ala Asp 
        595                 600                 605             


Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp Phe Cys Asn Thr Leu 
    610                 615                 620                 


Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp Leu Leu Leu His Ser 
625                 630                 635                 640 


Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg Ser His Pro Asn Lys 
                645                 650                 655     


Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr Trp Ile Met Ile Gln 
            660                 665                 670         


Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp Pro Tyr Asp Lys Pro 
        675                 680                 685             


Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser Gly Tyr Ser Thr Val 
    690                 695                 700                 


Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu Asn Gln Glu Val Ile 
705                 710                 715                 720 


Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp Lys Tyr Met Phe Ala 
                725                 730                 735     


Thr Lys Val Val His Leu Leu Gly Ser Glu Gln Gln Ser Ser Val Gln 
            740                 745                 750         


Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg Ala Ala Gln Phe Val 
        755                 760                 765             


Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala Asp Ala Ser Glu Asp 
    770                 775                 780                 


Gln Val Phe Val Cys Val Ser His Ser Asn Asn Arg Thr Asn Leu Tyr 
785                 790                 795                 800 


Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu Ser Leu Glu Asn Val 
                805                 810                 815     


Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp Thr Leu Val Arg Tyr 
            820                 825                 830         


Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg Val Glu Gly Leu Gln 
        835                 840                 845             


Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser Met Asn Glu Glu Asn 
    850                 855                 860                 


Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly Thr Trp Glu Phe Leu 
865                 870                 875                 880 


Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys Ile Asn Cys Glu Leu 
                885                 890                 895     


Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg Leu Ser Gln Leu Leu 
            900                 905                 910         


Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser Lys Glu Ser Ala Pro 
        915                 920                 925             


Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys Asn Leu Ala Ser Lys 
    930                 935                 940                 


Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala Arg Trp Arg Glu Ala 
945                 950                 955                 960 


Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp His Gly Gly Ile Ile 
                965                 970                 975     


Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu Leu Lys Tyr Ser Thr 
            980                 985                 990         


Asn Glu Gly Glu Thr Trp Lys Thr  Phe Ile Phe Ser Glu  Lys Pro Val 
        995                 1000                 1005             


Phe Val  Tyr Gly Leu Leu Thr  Glu Pro Gly Glu Lys  Ser Thr Val 
    1010                 1015                 1020             


Phe Thr  Ile Phe Gly Ser Asn  Lys Glu Asn Val His  Ser Trp Leu 
    1025                 1030                 1035             


Ile Leu  Gln Val Asn Ala Thr  Asp Ala Leu Gly Val  Pro Cys Thr 
    1040                 1045                 1050             


Glu Asn  Asp Tyr Lys Leu Trp  Ser Pro Ser Asp Glu  Arg Gly Asn 
    1055                 1060                 1065             


Glu Cys  Leu Leu Gly His Lys  Thr Val Phe Lys Arg  Arg Thr Pro 
    1070                 1075                 1080             


His Ala  Thr Cys Phe Asn Gly  Glu Asp Phe Asp Arg  Pro Val Val 
    1085                 1090                 1095             


Val Ser  Asn Cys Ser Cys Thr  Arg Glu Asp Tyr Glu  Cys Asp Phe 
    1100                 1105                 1110             


Gly Phe  Lys Met Ser Glu Asp  Leu Ser Leu Glu Val  Cys Val Pro 
    1115                 1120                 1125             


Asp Pro  Glu Phe Ser Gly Lys  Ser Tyr Ser Pro Pro  Val Pro Cys 
    1130                 1135                 1140             


Pro Val  Gly Ser Thr Tyr Arg  Arg Thr Arg Gly Tyr  Arg Lys Ile 
    1145                 1150                 1155             


Ser Gly  Asp Thr Cys Ser Gly  Gly Asp Val Glu Ala  Arg Leu Glu 
    1160                 1165                 1170             


Gly Glu  Leu Val Pro Cys Pro  Leu Ala Glu Glu Asn  Glu Phe Ile 
    1175                 1180                 1185             


Leu Tyr  Ala Val Arg Lys Ser  Ile Tyr Arg Tyr Asp  Leu Ala Ser 
    1190                 1195                 1200             


Gly Ala  Thr Glu Gln Leu Pro  Leu Thr Gly Leu Arg  Ala Ala Val 
    1205                 1210                 1215             


Ala Leu  Asp Phe Asp Tyr Glu  His Asn Cys Leu Tyr  Trp Ser Asp 
    1220                 1225                 1230             


Leu Ala  Leu Asp Val Ile Gln  Arg Leu Cys Leu Asn  Gly Ser Thr 
    1235                 1240                 1245             


Gly Gln  Glu Val Ile Ile Asn  Ser Gly Leu Glu Thr  Val Glu Ala 
    1250                 1255                 1260             


Leu Ala  Phe Glu Pro Leu Ser  Gln Leu Leu Tyr Trp  Val Asp Ala 
    1265                 1270                 1275             


Gly Phe  Lys Lys Ile Glu Val  Ala Asn Pro Asp Gly  Asp Phe Arg 
    1280                 1285                 1290             


Leu Thr  Ile Val Asn Ser Ser  Val Leu Asp Arg Pro  Arg Ala Leu 
    1295                 1300                 1305             


Val Leu  Val Pro Gln Glu Gly  Val Met Phe Trp Thr  Asp Trp Gly 
    1310                 1315                 1320             


Asp Leu  Lys Pro Gly Ile Tyr  Arg Ser Asn Met Asp  Gly Ser Ala 
    1325                 1330                 1335             


Ala Tyr  His Leu Val Ser Glu  Asp Val Lys Trp Pro  Asn Gly Ile 
    1340                 1345                 1350             


Ser Val  Asp Asp Gln Trp Ile  Tyr Trp Thr Asp Ala  Tyr Leu Glu 
    1355                 1360                 1365             


Cys Ile  Glu Arg Ile Thr Phe  Ser Gly Gln Gln Arg  Ser Val Ile 
    1370                 1375                 1380             


Leu Asp  Asn Leu Pro His Pro  Tyr Ala Ile Ala Val  Phe Lys Asn 
    1385                 1390                 1395             


Glu Ile  Tyr Trp Asp Asp Trp  Ser Gln Leu Ser Ile  Phe Arg Ala 
    1400                 1405                 1410             


Ser Lys  Tyr Ser Gly Ser Gln  Met Glu Ile Leu Ala  Asn Gln Leu 
    1415                 1420                 1425             


Thr Gly  Leu Met Asp Met Lys  Ile Phe Tyr Lys Gly  Lys Asn Thr 
    1430                 1435                 1440             


Gly Ser  Asn Ala Cys Val Pro  Arg Pro Cys Ser Leu  Leu Cys Leu 
    1445                 1450                 1455             


Pro Lys  Ala Asn Asn Ser Arg  Ser Cys Arg Cys Pro  Glu Asp Val 
    1460                 1465                 1470             


Ser Ser  Ser Val Leu Pro Ser  Gly Asp Leu Met Cys  Asp Cys Pro 
    1475                 1480                 1485             


Gln Gly  Tyr Gln Leu Lys Asn  Asn Thr Cys Val Lys  Gln Glu Asn 
    1490                 1495                 1500             


Thr Cys  Leu Arg Asn Gln Tyr  Arg Cys Ser Asn Gly  Asn Cys Ile 
    1505                 1510                 1515             


Asn Ser  Ile Trp Trp Cys Asp  Phe Asp Asn Asp Cys  Gly Asp Met 
    1520                 1525                 1530             


Ser Asp  Glu Arg Asn Cys Pro  Thr Thr Ile Cys Asp  Leu Asp Thr 
    1535                 1540                 1545             


Gln Phe  Arg Cys Gln Glu Ser  Gly Thr Cys Ile Pro  Leu Ser Tyr 
    1550                 1555                 1560             


Lys Cys  Asp Leu Glu Asp Asp  Cys Gly Asp Asn Ser  Asp Glu Ser 
    1565                 1570                 1575             


His Cys  Glu Met His Gln Cys  Arg Ser Asp Glu Tyr  Asn Cys Ser 
    1580                 1585                 1590             


Ser Gly  Met Cys Ile Arg Ser  Ser Trp Val Cys Asp  Gly Asp Asn 
    1595                 1600                 1605             


Asp Cys  Arg Asp Trp Ser Asp  Glu Ala Asn Cys Thr  Ala Ile Tyr 
    1610                 1615                 1620             


His Thr  Cys Glu Ala Ser Asn  Phe Gln Cys Arg Asn  Gly His Cys 
    1625                 1630                 1635             


Ile Pro  Gln Arg Trp Ala Cys  Asp Gly Asp Thr Asp  Cys Gln Asp 
    1640                 1645                 1650             


Gly Ser  Asp Glu Asp Pro Val  Asn Cys Glu Lys Lys  Cys Asn Gly 
    1655                 1660                 1665             


Phe Arg  Cys Pro Asn Gly Thr  Cys Ile Pro Ser Ser  Lys His Cys 
    1670                 1675                 1680             


Asp Gly  Leu Arg Asp Cys Ser  Asp Gly Ser Asp Glu  Gln His Cys 
    1685                 1690                 1695             


Glu Pro  Leu Cys Thr His Phe  Met Asp Phe Val Cys  Lys Asn Arg 
    1700                 1705                 1710             


Gln Gln  Cys Leu Phe His Ser  Met Val Cys Asp Gly  Ile Ile Gln 
    1715                 1720                 1725             


Cys Arg  Asp Gly Ser Asp Glu  Asp Ala Ala Phe Ala  Gly Cys Ser 
    1730                 1735                 1740             


Gln Asp  Pro Glu Phe His Lys  Val Cys Asp Glu Phe  Gly Phe Gln 
    1745                 1750                 1755             


Cys Gln  Asn Gly Val Cys Ile  Ser Leu Ile Trp Lys  Cys Asp Gly 
    1760                 1765                 1770             


Met Asp  Asp Cys Gly Asp Tyr  Ser Asp Glu Ala Asn  Cys Glu Asn 
    1775                 1780                 1785             


Pro Thr  Glu Ala Pro Asn Cys  Ser Arg Tyr Phe Gln  Phe Arg Cys 
    1790                 1795                 1800             


Glu Asn  Gly His Cys Ile Pro  Asn Arg Trp Lys Cys  Asp Arg Glu 
    1805                 1810                 1815             


Asn Asp  Cys Gly Asp Trp Ser  Asp Glu Lys Asp Cys  Gly Asp Ser 
    1820                 1825                 1830             


His Ile  Leu Pro Phe Ser Thr  Pro Gly Pro Ser Thr  Cys Leu Pro 
    1835                 1840                 1845             


Asn Tyr  Tyr Arg Cys Ser Ser  Gly Thr Cys Val Met  Asp Thr Trp 
    1850                 1855                 1860             


Val Cys  Asp Gly Tyr Arg Asp  Cys Ala Asp Gly Ser  Asp Glu Glu 
    1865                 1870                 1875             


Ala Cys  Pro Leu Leu Ala Asn  Val Thr Ala Ala Ser  Thr Pro Thr 
    1880                 1885                 1890             


Gln Leu  Gly Arg Cys Asp Arg  Phe Glu Phe Glu Cys  His Gln Pro 
    1895                 1900                 1905             


Lys Thr  Cys Ile Pro Asn Trp  Lys Arg Cys Asp Gly  His Gln Asp 
    1910                 1915                 1920             


Cys Gln  Asp Gly Arg Asp Glu  Ala Asn Cys Pro Thr  His Ser Thr 
    1925                 1930                 1935             


Leu Thr  Cys Met Ser Arg Glu  Phe Gln Cys Glu Asp  Gly Glu Ala 
    1940                 1945                 1950             


Cys Ile  Val Leu Ser Glu Arg  Cys Asp Gly Phe Leu  Asp Cys Ser 
    1955                 1960                 1965             


Asp Glu  Ser Asp Glu Lys Ala  Cys Ser Asp Glu Leu  Thr Val Tyr 
    1970                 1975                 1980             


Lys Val  Gln Asn Leu Gln Trp  Thr Ala Asp Phe Ser  Gly Asp Val 
    1985                 1990                 1995             


Thr Leu  Thr Trp Met Arg Pro  Lys Lys Met Pro Ser  Ala Ser Cys 
    2000                 2005                 2010             


Val Tyr  Asn Val Tyr Tyr Arg  Val Val Gly Glu Ser  Ile Trp Lys 
    2015                 2020                 2025             


Thr Leu  Glu Thr His Ser Asn  Lys Thr Asn Thr Val  Leu Lys Val 
    2030                 2035                 2040             


Leu Lys  Pro Asp Thr Thr Tyr  Gln Val Lys Val Gln  Val Gln Cys 
    2045                 2050                 2055             


Leu Ser  Lys Ala His Asn Thr  Asn Asp Phe Val Thr  Leu Arg Thr 
    2060                 2065                 2070             


Pro Glu  Gly Leu Pro Asp Ala  Pro Arg Asn Leu Gln  Leu Ser Leu 
    2075                 2080                 2085             


Pro Arg  Glu Ala Glu Gly Val  Ile Val Gly His Trp  Ala Pro Pro 
    2090                 2095                 2100             


Ile His  Thr His Gly Leu Ile  Arg Glu Tyr Ile Val  Glu Tyr Ser 
    2105                 2110                 2115             


Arg Ser  Gly Ser Lys Met Trp  Ala Ser Gln Arg Ala  Ala Ser Asn 
    2120                 2125                 2130             


Phe Thr  Glu Ile Lys Asn Leu  Leu Val Asn Thr Leu  Tyr Thr Val 
    2135                 2140                 2145             


Arg Val  Ala Ala Val Thr Ser  Arg Gly Ile Gly Asn  Trp Ser Asp 
    2150                 2155                 2160             


Ser Lys  Ser Ile Thr Thr Ile  Lys Gly Lys Val Ile  Pro Pro Pro 
    2165                 2170                 2175             


Asp Ile  His Ile Asp Ser Tyr  Gly Glu Asn Tyr Leu  Ser Phe Thr 
    2180                 2185                 2190             


Leu Thr  Met Glu Ser Asp Ile  Lys Val Asn Gly Tyr  Val Val Asn 
    2195                 2200                 2205             


Leu Phe  Trp Ala Phe Asp Thr  His Lys Gln Glu Arg  Arg Thr Leu 
    2210                 2215                 2220             


Asn Phe  Arg Gly Ser Ile Leu  Ser His Lys Val Gly  Asn Leu Thr 
    2225                 2230                 2235             


Ala His  Thr Ser Tyr Glu Ile  Ser Ala Trp Ala Lys  Thr Asp Leu 
    2240                 2245                 2250             


Gly Asp  Ser Pro Leu Ala Phe  Glu His Val Met Thr  Arg Gly Val 
    2255                 2260                 2265             


Arg Pro  Pro Ala Pro Ser Leu  Lys Ala Lys Ala Ile  Asn Gln Thr 
    2270                 2275                 2280             


Ala Val  Glu Cys Thr Trp Thr  Gly Pro Arg Asn Val  Val Tyr Gly 
    2285                 2290                 2295             


Ile Phe  Tyr Ala Thr Ser Phe  Leu Asp Leu Tyr Arg  Asn Pro Lys 
    2300                 2305                 2310             


Ser Leu  Thr Thr Ser Leu His  Asn Lys Thr Val Ile  Val Ser Lys 
    2315                 2320                 2325             


Asp Glu  Gln Tyr Leu Phe Leu  Val Arg Val Val Val  Pro Tyr Gln 
    2330                 2335                 2340             


Gly Pro  Ser Ser Asp Tyr Val  Val Val Lys Met Ile  Pro Asp Ser 
    2345                 2350                 2355             


Arg Leu  Pro Pro Arg His Leu  His Val Val His Thr  Gly Lys Thr 
    2360                 2365                 2370             


Ser Val  Val Ile Lys Trp Glu  Ser Pro Tyr Asp Ser  Pro Asp Gln 
    2375                 2380                 2385             


Asp Leu  Leu Tyr Ala Val Ala  Val Lys Asp Leu Ile  Arg Lys Thr 
    2390                 2395                 2400             


Asp Arg  Ser Tyr Lys Val Lys  Ser Arg Asn Ser Thr  Val Glu Tyr 
    2405                 2410                 2415             


Thr Leu  Asn Lys Leu Glu Pro  Gly Gly Lys Tyr His  Ile Ile Val 
    2420                 2425                 2430             


Gln Leu  Gly Asn Met Ser Lys  Asp Ser Ser Ile Lys  Ile Thr Thr 
    2435                 2440                 2445             


Val Ser  Leu Ser Ala Pro Asp  Ala Leu Lys Ile Ile  Thr Glu Asn 
    2450                 2455                 2460             


Asp His  Val Leu Leu Phe Trp  Lys Ser Leu Ala Leu  Lys Glu Lys 
    2465                 2470                 2475             


His Phe  Asn Glu Ser Arg Gly  Tyr Glu Ile His Met  Phe Asp Ser 
    2480                 2485                 2490             


Ala Met  Asn Ile Thr Ala Tyr  Leu Gly Asn Thr Thr  Asp Asn Phe 
    2495                 2500                 2505             


Phe Lys  Ile Ser Asn Leu Lys  Met Gly His Asn Tyr  Thr Phe Thr 
    2510                 2515                 2520             


Val Gln  Ala Arg Cys Leu Phe  Gly Asn Gln Ile Cys  Gly Glu Pro 
    2525                 2530                 2535             


Ala Ile  Leu Leu Tyr Asp Glu  Leu Gly Ser Gly Ala  Asp Ala Ser 
    2540                 2545                 2550             


Ala Thr  Gln Ala Ala Arg Ser  Thr Asp Val Ala Ala  Val Val Val 
    2555                 2560                 2565             


Pro Ile  Leu Phe Leu Ile Leu  Leu Ser Leu Gly Val  Gly Phe Ala 
    2570                 2575                 2580             


Ile Leu  Tyr Thr Lys His Arg  Arg Leu Gln Ser Ser  Phe Thr Ala 
    2585                 2590                 2595             


Phe Ala  Asn Ser His Tyr Ser  Ser Arg Leu Gly Ser  Ala Ile Phe 
    2600                 2605                 2610             


Ser Ser  Gly Asp Asp Leu Gly  Glu Asp Asp Glu Asp  Ala Pro Met 
    2615                 2620                 2625             


Ile Thr  Gly Phe Ser Asp Asp  Val Pro Met Val Ile  Ala 
    2630                 2635                 2640     


<210>  2
<211>  2644
<212>  PRT
<213>  Artificial

<220>
<223>  sorLA-reporter construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2644)
<223>  sorLA-reporter construct

<400>  2

Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu 
            20                  25                  30          


Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr 
        35                  40                  45              


Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser 
    50                  55                  60                  


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu 
65                  70                  75                  80  


Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu 
                85                  90                  95      


Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr 
            100                 105                 110         


Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly 
        115                 120                 125             


Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn 
    130                 135                 140                 


Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val 
145                 150                 155                 160 


Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr 
                165                 170                 175     


Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro 
            180                 185                 190         


Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile 
        195                 200                 205             


Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met 
    210                 215                 220                 


Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln 
225                 230                 235                 240 


Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala 
                245                 250                 255     


Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln 
            260                 265                 270         


Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro 
        275                 280                 285             


Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser 
    290                 295                 300                 


Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro 
305                 310                 315                 320 


Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His 
                325                 330                 335     


His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp 
            340                 345                 350         


Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu 
        355                 360                 365             


Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr 
    370                 375                 380                 


Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg 
385                 390                 395                 400 


Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr 
                405                 410                 415     


Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly 
            420                 425                 430         


Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr 
        435                 440                 445             


His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His 
    450                 455                 460                 


Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala 
465                 470                 475                 480 


Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro 
                485                 490                 495     


Ala Gly Thr Thr Asp Ala Ala His Pro Gly Leu Ser Arg Ser Glu Ser 
            500                 505                 510         


Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val Ser Leu 
        515                 520                 525             


Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu Lys Ser 
    530                 535                 540                 


Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala Arg Pro 
545                 550                 555                 560 


Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser Phe Lys 
                565                 570                 575     


Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser Glu Ala 
            580                 585                 590         


Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg Tyr Ile 
        595                 600                 605             


Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp Phe Cys 
    610                 615                 620                 


Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp Leu Leu 
625                 630                 635                 640 


Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg Ser His 
                645                 650                 655     


Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr Trp Ile 
            660                 665                 670         


Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp Pro Tyr 
        675                 680                 685             


Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser Gly Tyr 
    690                 695                 700                 


Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu Asn Gln 
705                 710                 715                 720 


Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp Lys Tyr 
                725                 730                 735     


Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln Gln Ser 
            740                 745                 750         


Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg Ala Ala 
        755                 760                 765             


Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala Asp Ala 
    770                 775                 780                 


Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn Arg Thr 
785                 790                 795                 800 


Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu Ser Leu 
                805                 810                 815     


Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp Thr Leu 
            820                 825                 830         


Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg Val Glu 
        835                 840                 845             


Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser Met Asn 
    850                 855                 860                 


Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly Thr Trp 
865                 870                 875                 880 


Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys Ile Asn 
                885                 890                 895     


Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg Leu Ser 
            900                 905                 910         


Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser Lys Glu 
        915                 920                 925             


Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys Asn Leu 
    930                 935                 940                 


Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala Arg Trp 
945                 950                 955                 960 


Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp His Gly 
                965                 970                 975     


Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu Leu Lys 
            980                 985                 990         


Tyr Ser Thr Asn Glu Gly Glu Thr  Trp Lys Thr Phe Ile  Phe Ser Glu 
        995                 1000                 1005             


Lys Pro  Val Phe Val Tyr Gly  Leu Leu Thr Glu Pro  Gly Glu Lys 
    1010                 1015                 1020             


Ser Thr  Val Phe Thr Ile Phe  Gly Ser Asn Lys Glu  Asn Val His 
    1025                 1030                 1035             


Ser Trp  Leu Ile Leu Gln Val  Asn Ala Thr Asp Ala  Leu Gly Val 
    1040                 1045                 1050             


Pro Cys  Thr Glu Asn Asp Tyr  Lys Leu Trp Ser Pro  Ser Asp Glu 
    1055                 1060                 1065             


Arg Gly  Asn Glu Cys Leu Leu  Gly His Lys Thr Val  Phe Lys Arg 
    1070                 1075                 1080             


Arg Thr  Pro His Ala Thr Cys  Phe Asn Gly Glu Asp  Phe Asp Arg 
    1085                 1090                 1095             


Pro Val  Val Val Ser Asn Cys  Ser Cys Thr Arg Glu  Asp Tyr Glu 
    1100                 1105                 1110             


Cys Asp  Phe Gly Phe Lys Met  Ser Glu Asp Leu Ser  Leu Glu Val 
    1115                 1120                 1125             


Cys Val  Pro Asp Pro Glu Phe  Ser Gly Lys Ser Tyr  Ser Pro Pro 
    1130                 1135                 1140             


Val Pro  Cys Pro Val Gly Ser  Thr Tyr Arg Arg Thr  Arg Gly Tyr 
    1145                 1150                 1155             


Arg Lys  Ile Ser Gly Asp Thr  Cys Ser Gly Gly Asp  Val Glu Ala 
    1160                 1165                 1170             


Arg Leu  Glu Gly Glu Leu Val  Pro Cys Pro Leu Ala  Glu Glu Asn 
    1175                 1180                 1185             


Glu Phe  Ile Leu Tyr Ala Val  Arg Lys Ser Ile Tyr  Arg Tyr Asp 
    1190                 1195                 1200             


Leu Ala  Ser Gly Ala Thr Glu  Gln Leu Pro Leu Thr  Gly Leu Arg 
    1205                 1210                 1215             


Ala Ala  Val Ala Leu Asp Phe  Asp Tyr Glu His Asn  Cys Leu Tyr 
    1220                 1225                 1230             


Trp Ser  Asp Leu Ala Leu Asp  Val Ile Gln Arg Leu  Cys Leu Asn 
    1235                 1240                 1245             


Gly Ser  Thr Gly Gln Glu Val  Ile Ile Asn Ser Gly  Leu Glu Thr 
    1250                 1255                 1260             


Val Glu  Ala Leu Ala Phe Glu  Pro Leu Ser Gln Leu  Leu Tyr Trp 
    1265                 1270                 1275             


Val Asp  Ala Gly Phe Lys Lys  Ile Glu Val Ala Asn  Pro Asp Gly 
    1280                 1285                 1290             


Asp Phe  Arg Leu Thr Ile Val  Asn Ser Ser Val Leu  Asp Arg Pro 
    1295                 1300                 1305             


Arg Ala  Leu Val Leu Val Pro  Gln Glu Gly Val Met  Phe Trp Thr 
    1310                 1315                 1320             


Asp Trp  Gly Asp Leu Lys Pro  Gly Ile Tyr Arg Ser  Asn Met Asp 
    1325                 1330                 1335             


Gly Ser  Ala Ala Tyr His Leu  Val Ser Glu Asp Val  Lys Trp Pro 
    1340                 1345                 1350             


Asn Gly  Ile Ser Val Asp Asp  Gln Trp Ile Tyr Trp  Thr Asp Ala 
    1355                 1360                 1365             


Tyr Leu  Glu Cys Ile Glu Arg  Ile Thr Phe Ser Gly  Gln Gln Arg 
    1370                 1375                 1380             


Ser Val  Ile Leu Asp Asn Leu  Pro His Pro Tyr Ala  Ile Ala Val 
    1385                 1390                 1395             


Phe Lys  Asn Glu Ile Tyr Trp  Asp Asp Trp Ser Gln  Leu Ser Ile 
    1400                 1405                 1410             


Phe Arg  Ala Ser Lys Tyr Ser  Gly Ser Gln Met Glu  Ile Leu Ala 
    1415                 1420                 1425             


Asn Gln  Leu Thr Gly Leu Met  Asp Met Lys Ile Phe  Tyr Lys Gly 
    1430                 1435                 1440             


Lys Asn  Thr Gly Ser Asn Ala  Cys Val Pro Arg Pro  Cys Ser Leu 
    1445                 1450                 1455             


Leu Cys  Leu Pro Lys Ala Asn  Asn Ser Arg Ser Cys  Arg Cys Pro 
    1460                 1465                 1470             


Glu Asp  Val Ser Ser Ser Val  Leu Pro Ser Gly Asp  Leu Met Cys 
    1475                 1480                 1485             


Asp Cys  Pro Gln Gly Tyr Gln  Leu Lys Asn Asn Thr  Cys Val Lys 
    1490                 1495                 1500             


Gln Glu  Asn Thr Cys Leu Arg  Asn Gln Tyr Arg Cys  Ser Asn Gly 
    1505                 1510                 1515             


Asn Cys  Ile Asn Ser Ile Trp  Trp Cys Asp Phe Asp  Asn Asp Cys 
    1520                 1525                 1530             


Gly Asp  Met Ser Asp Glu Arg  Asn Cys Pro Thr Thr  Ile Cys Asp 
    1535                 1540                 1545             


Leu Asp  Thr Gln Phe Arg Cys  Gln Glu Ser Gly Thr  Cys Ile Pro 
    1550                 1555                 1560             


Leu Ser  Tyr Lys Cys Asp Leu  Glu Asp Asp Cys Gly  Asp Asn Ser 
    1565                 1570                 1575             


Asp Glu  Ser His Cys Glu Met  His Gln Cys Arg Ser  Asp Glu Tyr 
    1580                 1585                 1590             


Asn Cys  Ser Ser Gly Met Cys  Ile Arg Ser Ser Trp  Val Cys Asp 
    1595                 1600                 1605             


Gly Asp  Asn Asp Cys Arg Asp  Trp Ser Asp Glu Ala  Asn Cys Thr 
    1610                 1615                 1620             


Ala Ile  Tyr His Thr Cys Glu  Ala Ser Asn Phe Gln  Cys Arg Asn 
    1625                 1630                 1635             


Gly His  Cys Ile Pro Gln Arg  Trp Ala Cys Asp Gly  Asp Thr Asp 
    1640                 1645                 1650             


Cys Gln  Asp Gly Ser Asp Glu  Asp Pro Val Asn Cys  Glu Lys Lys 
    1655                 1660                 1665             


Cys Asn  Gly Phe Arg Cys Pro  Asn Gly Thr Cys Ile  Pro Ser Ser 
    1670                 1675                 1680             


Lys His  Cys Asp Gly Leu Arg  Asp Cys Ser Asp Gly  Ser Asp Glu 
    1685                 1690                 1695             


Gln His  Cys Glu Pro Leu Cys  Thr His Phe Met Asp  Phe Val Cys 
    1700                 1705                 1710             


Lys Asn  Arg Gln Gln Cys Leu  Phe His Ser Met Val  Cys Asp Gly 
    1715                 1720                 1725             


Ile Ile  Gln Cys Arg Asp Gly  Ser Asp Glu Asp Ala  Ala Phe Ala 
    1730                 1735                 1740             


Gly Cys  Ser Gln Asp Pro Glu  Phe His Lys Val Cys  Asp Glu Phe 
    1745                 1750                 1755             


Gly Phe  Gln Cys Gln Asn Gly  Val Cys Ile Ser Leu  Ile Trp Lys 
    1760                 1765                 1770             


Cys Asp  Gly Met Asp Asp Cys  Gly Asp Tyr Ser Asp  Glu Ala Asn 
    1775                 1780                 1785             


Cys Glu  Asn Pro Thr Glu Ala  Pro Asn Cys Ser Arg  Tyr Phe Gln 
    1790                 1795                 1800             


Phe Arg  Cys Glu Asn Gly His  Cys Ile Pro Asn Arg  Trp Lys Cys 
    1805                 1810                 1815             


Asp Arg  Glu Asn Asp Cys Gly  Asp Trp Ser Asp Glu  Lys Asp Cys 
    1820                 1825                 1830             


Gly Asp  Ser His Ile Leu Pro  Phe Ser Thr Pro Gly  Pro Ser Thr 
    1835                 1840                 1845             


Cys Leu  Pro Asn Tyr Tyr Arg  Cys Ser Ser Gly Thr  Cys Val Met 
    1850                 1855                 1860             


Asp Thr  Trp Val Cys Asp Gly  Tyr Arg Asp Cys Ala  Asp Gly Ser 
    1865                 1870                 1875             


Asp Glu  Glu Ala Cys Pro Leu  Leu Ala Asn Val Thr  Ala Ala Ser 
    1880                 1885                 1890             


Thr Pro  Thr Gln Leu Gly Arg  Cys Asp Arg Phe Glu  Phe Glu Cys 
    1895                 1900                 1905             


His Gln  Pro Lys Thr Cys Ile  Pro Asn Trp Lys Arg  Cys Asp Gly 
    1910                 1915                 1920             


His Gln  Asp Cys Gln Asp Gly  Arg Asp Glu Ala Asn  Cys Pro Thr 
    1925                 1930                 1935             


His Ser  Thr Leu Thr Cys Met  Ser Arg Glu Phe Gln  Cys Glu Asp 
    1940                 1945                 1950             


Gly Glu  Ala Cys Ile Val Leu  Ser Glu Arg Cys Asp  Gly Phe Leu 
    1955                 1960                 1965             


Asp Cys  Ser Asp Glu Ser Asp  Glu Lys Ala Cys Ser  Asp Glu Leu 
    1970                 1975                 1980             


Thr Val  Tyr Lys Val Gln Asn  Leu Gln Trp Thr Ala  Asp Phe Ser 
    1985                 1990                 1995             


Gly Asp  Val Thr Leu Thr Trp  Met Arg Pro Lys Lys  Met Pro Ser 
    2000                 2005                 2010             


Ala Ser  Cys Val Tyr Asn Val  Tyr Tyr Arg Val Val  Gly Glu Ser 
    2015                 2020                 2025             


Ile Trp  Lys Thr Leu Glu Thr  His Ser Asn Lys Thr  Asn Thr Val 
    2030                 2035                 2040             


Leu Lys  Val Leu Lys Pro Asp  Thr Thr Tyr Gln Val  Lys Val Gln 
    2045                 2050                 2055             


Val Gln  Cys Leu Ser Lys Ala  His Asn Thr Asn Asp  Phe Val Thr 
    2060                 2065                 2070             


Leu Arg  Thr Pro Glu Gly Leu  Pro Asp Ala Pro Arg  Asn Leu Gln 
    2075                 2080                 2085             


Leu Ser  Leu Pro Arg Glu Ala  Glu Gly Val Ile Val  Gly His Trp 
    2090                 2095                 2100             


Ala Pro  Pro Ile His Thr His  Gly Leu Ile Arg Glu  Tyr Ile Val 
    2105                 2110                 2115             


Glu Tyr  Ser Arg Ser Gly Ser  Lys Met Trp Ala Ser  Gln Arg Ala 
    2120                 2125                 2130             


Ala Ser  Asn Phe Thr Glu Ile  Lys Asn Leu Leu Val  Asn Thr Leu 
    2135                 2140                 2145             


Tyr Thr  Val Arg Val Ala Ala  Val Thr Ser Arg Gly  Ile Gly Asn 
    2150                 2155                 2160             


Trp Ser  Asp Ser Lys Ser Ile  Thr Thr Ile Lys Gly  Lys Val Ile 
    2165                 2170                 2175             


Pro Pro  Pro Asp Ile His Ile  Asp Ser Tyr Gly Glu  Asn Tyr Leu 
    2180                 2185                 2190             


Ser Phe  Thr Leu Thr Met Glu  Ser Asp Ile Lys Val  Asn Gly Tyr 
    2195                 2200                 2205             


Val Val  Asn Leu Phe Trp Ala  Phe Asp Thr His Lys  Gln Glu Arg 
    2210                 2215                 2220             


Arg Thr  Leu Asn Phe Arg Gly  Ser Ile Leu Ser His  Lys Val Gly 
    2225                 2230                 2235             


Asn Leu  Thr Ala His Thr Ser  Tyr Glu Ile Ser Ala  Trp Ala Lys 
    2240                 2245                 2250             


Thr Asp  Leu Gly Asp Ser Pro  Leu Ala Phe Glu His  Val Met Thr 
    2255                 2260                 2265             


Arg Gly  Val Arg Pro Pro Ala  Pro Ser Leu Lys Ala  Lys Ala Ile 
    2270                 2275                 2280             


Asn Gln  Thr Ala Val Glu Cys  Thr Trp Thr Gly Pro  Arg Asn Val 
    2285                 2290                 2295             


Val Tyr  Gly Ile Phe Tyr Ala  Thr Ser Phe Leu Asp  Leu Tyr Arg 
    2300                 2305                 2310             


Asn Pro  Lys Ser Leu Thr Thr  Ser Leu His Asn Lys  Thr Val Ile 
    2315                 2320                 2325             


Val Ser  Lys Asp Glu Gln Tyr  Leu Phe Leu Val Arg  Val Val Val 
    2330                 2335                 2340             


Pro Tyr  Gln Gly Pro Ser Ser  Asp Tyr Val Val Val  Lys Met Ile 
    2345                 2350                 2355             


Pro Asp  Ser Arg Leu Pro Pro  Arg His Leu His Val  Val His Thr 
    2360                 2365                 2370             


Gly Lys  Thr Ser Val Val Ile  Lys Trp Glu Ser Pro  Tyr Asp Ser 
    2375                 2380                 2385             


Pro Asp  Gln Asp Leu Leu Tyr  Ala Val Ala Val Lys  Asp Leu Ile 
    2390                 2395                 2400             


Arg Lys  Thr Asp Arg Ser Tyr  Lys Val Lys Ser Arg  Asn Ser Thr 
    2405                 2410                 2415             


Val Glu  Tyr Thr Leu Asn Lys  Leu Glu Pro Gly Gly  Lys Tyr His 
    2420                 2425                 2430             


Ile Ile  Val Gln Leu Gly Asn  Met Ser Lys Asp Ser  Ser Ile Lys 
    2435                 2440                 2445             


Ile Thr  Thr Val Ser Leu Ser  Ala Pro Asp Ala Leu  Lys Ile Ile 
    2450                 2455                 2460             


Thr Glu  Asn Asp His Val Leu  Leu Phe Trp Lys Ser  Leu Ala Leu 
    2465                 2470                 2475             


Lys Glu  Lys His Phe Asn Glu  Ser Arg Gly Tyr Glu  Ile His Met 
    2480                 2485                 2490             


Phe Asp  Ser Ala Met Asn Ile  Thr Ala Tyr Leu Gly  Asn Thr Thr 
    2495                 2500                 2505             


Asp Asn  Phe Phe Lys Ile Ser  Asn Leu Lys Met Gly  His Asn Tyr 
    2510                 2515                 2520             


Thr Phe  Thr Val Gln Ala Arg  Cys Leu Phe Gly Asn  Gln Ile Cys 
    2525                 2530                 2535             


Gly Glu  Pro Ala Ile Leu Leu  Tyr Asp Glu Leu Gly  Ser Gly Ala 
    2540                 2545                 2550             


Asp Ala  Ser Ala Thr Gln Ala  Ala Arg Ser Thr Asp  Val Ala Ala 
    2555                 2560                 2565             


Val Val  Val Pro Ile Leu Phe  Leu Ile Leu Leu Ser  Leu Gly Val 
    2570                 2575                 2580             


Gly Phe  Ala Ile Leu Tyr Thr  Lys His Arg Arg Leu  Gln Ser Ser 
    2585                 2590                 2595             


Phe Thr  Ala Phe Ala Asn Ser  His Tyr Ser Ser Arg  Leu Gly Ser 
    2600                 2605                 2610             


Ala Ile  Phe Ser Ser Gly Asp  Asp Leu Gly Glu Asp  Asp Glu Asp 
    2615                 2620                 2625             


Ala Pro  Met Ile Thr Gly Phe  Ser Asp Asp Val Pro  Met Val Ile 
    2630                 2635                 2640             


Ala 
    


<210>  3
<211>  2647
<212>  PRT
<213>  Artificial

<220>
<223>  sorLA-reporter construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2647)
<223>  sorLA-reporter construct

<400>  3

Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu 
            20                  25                  30          


Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr 
        35                  40                  45              


Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser 
    50                  55                  60                  


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu 
65                  70                  75                  80  


Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu 
                85                  90                  95      


Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr 
            100                 105                 110         


Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly 
        115                 120                 125             


Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn 
    130                 135                 140                 


Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val 
145                 150                 155                 160 


Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr 
                165                 170                 175     


Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro 
            180                 185                 190         


Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile 
        195                 200                 205             


Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met 
    210                 215                 220                 


Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln 
225                 230                 235                 240 


Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala 
                245                 250                 255     


Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln 
            260                 265                 270         


Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro 
        275                 280                 285             


Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser 
    290                 295                 300                 


Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro 
305                 310                 315                 320 


Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His 
                325                 330                 335     


His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp 
            340                 345                 350         


Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu 
        355                 360                 365             


Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr 
    370                 375                 380                 


Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg 
385                 390                 395                 400 


Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr 
                405                 410                 415     


Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly 
            420                 425                 430         


Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr 
        435                 440                 445             


His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His 
    450                 455                 460                 


Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala 
465                 470                 475                 480 


Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro 
                485                 490                 495     


Ala Gly Thr Thr Asp Ala Ala His Pro Gly Leu Ser Arg Ser Ser Gly 
            500                 505                 510         


Gly Glu Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln 
        515                 520                 525             


Val Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly 
    530                 535                 540                 


Glu Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu 
545                 550                 555                 560 


Ala Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys 
                565                 570                 575     


Ser Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg 
            580                 585                 590         


Ser Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys 
        595                 600                 605             


Arg Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe 
    610                 615                 620                 


Asp Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala 
625                 630                 635                 640 


Asp Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp 
                645                 650                 655     


Arg Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln 
            660                 665                 670         


Thr Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile 
        675                 680                 685             


Asp Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro 
    690                 695                 700                 


Ser Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg 
705                 710                 715                 720 


Glu Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg 
                725                 730                 735     


Asp Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu 
            740                 745                 750         


Gln Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met 
        755                 760                 765             


Arg Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile 
    770                 775                 780                 


Ala Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn 
785                 790                 795                 800 


Asn Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser 
                805                 810                 815     


Leu Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser 
            820                 825                 830         


Asp Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His 
        835                 840                 845             


Arg Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly 
    850                 855                 860                 


Ser Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly 
865                 870                 875                 880 


Gly Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu 
                885                 890                 895     


Lys Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln 
            900                 905                 910         


Arg Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu 
        915                 920                 925             


Ser Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly 
    930                 935                 940                 


Lys Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly 
945                 950                 955                 960 


Ala Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly 
                965                 970                 975     


Asp His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn 
            980                 985                 990         


Glu Leu Lys Tyr Ser Thr Asn Glu  Gly Glu Thr Trp Lys  Thr Phe Ile 
        995                 1000                 1005             


Phe Ser  Glu Lys Pro Val Phe  Val Tyr Gly Leu Leu  Thr Glu Pro 
    1010                 1015                 1020             


Gly Glu  Lys Ser Thr Val Phe  Thr Ile Phe Gly Ser  Asn Lys Glu 
    1025                 1030                 1035             


Asn Val  His Ser Trp Leu Ile  Leu Gln Val Asn Ala  Thr Asp Ala 
    1040                 1045                 1050             


Leu Gly  Val Pro Cys Thr Glu  Asn Asp Tyr Lys Leu  Trp Ser Pro 
    1055                 1060                 1065             


Ser Asp  Glu Arg Gly Asn Glu  Cys Leu Leu Gly His  Lys Thr Val 
    1070                 1075                 1080             


Phe Lys  Arg Arg Thr Pro His  Ala Thr Cys Phe Asn  Gly Glu Asp 
    1085                 1090                 1095             


Phe Asp  Arg Pro Val Val Val  Ser Asn Cys Ser Cys  Thr Arg Glu 
    1100                 1105                 1110             


Asp Tyr  Glu Cys Asp Phe Gly  Phe Lys Met Ser Glu  Asp Leu Ser 
    1115                 1120                 1125             


Leu Glu  Val Cys Val Pro Asp  Pro Glu Phe Ser Gly  Lys Ser Tyr 
    1130                 1135                 1140             


Ser Pro  Pro Val Pro Cys Pro  Val Gly Ser Thr Tyr  Arg Arg Thr 
    1145                 1150                 1155             


Arg Gly  Tyr Arg Lys Ile Ser  Gly Asp Thr Cys Ser  Gly Gly Asp 
    1160                 1165                 1170             


Val Glu  Ala Arg Leu Glu Gly  Glu Leu Val Pro Cys  Pro Leu Ala 
    1175                 1180                 1185             


Glu Glu  Asn Glu Phe Ile Leu  Tyr Ala Val Arg Lys  Ser Ile Tyr 
    1190                 1195                 1200             


Arg Tyr  Asp Leu Ala Ser Gly  Ala Thr Glu Gln Leu  Pro Leu Thr 
    1205                 1210                 1215             


Gly Leu  Arg Ala Ala Val Ala  Leu Asp Phe Asp Tyr  Glu His Asn 
    1220                 1225                 1230             


Cys Leu  Tyr Trp Ser Asp Leu  Ala Leu Asp Val Ile  Gln Arg Leu 
    1235                 1240                 1245             


Cys Leu  Asn Gly Ser Thr Gly  Gln Glu Val Ile Ile  Asn Ser Gly 
    1250                 1255                 1260             


Leu Glu  Thr Val Glu Ala Leu  Ala Phe Glu Pro Leu  Ser Gln Leu 
    1265                 1270                 1275             


Leu Tyr  Trp Val Asp Ala Gly  Phe Lys Lys Ile Glu  Val Ala Asn 
    1280                 1285                 1290             


Pro Asp  Gly Asp Phe Arg Leu  Thr Ile Val Asn Ser  Ser Val Leu 
    1295                 1300                 1305             


Asp Arg  Pro Arg Ala Leu Val  Leu Val Pro Gln Glu  Gly Val Met 
    1310                 1315                 1320             


Phe Trp  Thr Asp Trp Gly Asp  Leu Lys Pro Gly Ile  Tyr Arg Ser 
    1325                 1330                 1335             


Asn Met  Asp Gly Ser Ala Ala  Tyr His Leu Val Ser  Glu Asp Val 
    1340                 1345                 1350             


Lys Trp  Pro Asn Gly Ile Ser  Val Asp Asp Gln Trp  Ile Tyr Trp 
    1355                 1360                 1365             


Thr Asp  Ala Tyr Leu Glu Cys  Ile Glu Arg Ile Thr  Phe Ser Gly 
    1370                 1375                 1380             


Gln Gln  Arg Ser Val Ile Leu  Asp Asn Leu Pro His  Pro Tyr Ala 
    1385                 1390                 1395             


Ile Ala  Val Phe Lys Asn Glu  Ile Tyr Trp Asp Asp  Trp Ser Gln 
    1400                 1405                 1410             


Leu Ser  Ile Phe Arg Ala Ser  Lys Tyr Ser Gly Ser  Gln Met Glu 
    1415                 1420                 1425             


Ile Leu  Ala Asn Gln Leu Thr  Gly Leu Met Asp Met  Lys Ile Phe 
    1430                 1435                 1440             


Tyr Lys  Gly Lys Asn Thr Gly  Ser Asn Ala Cys Val  Pro Arg Pro 
    1445                 1450                 1455             


Cys Ser  Leu Leu Cys Leu Pro  Lys Ala Asn Asn Ser  Arg Ser Cys 
    1460                 1465                 1470             


Arg Cys  Pro Glu Asp Val Ser  Ser Ser Val Leu Pro  Ser Gly Asp 
    1475                 1480                 1485             


Leu Met  Cys Asp Cys Pro Gln  Gly Tyr Gln Leu Lys  Asn Asn Thr 
    1490                 1495                 1500             


Cys Val  Lys Gln Glu Asn Thr  Cys Leu Arg Asn Gln  Tyr Arg Cys 
    1505                 1510                 1515             


Ser Asn  Gly Asn Cys Ile Asn  Ser Ile Trp Trp Cys  Asp Phe Asp 
    1520                 1525                 1530             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Arg Asn Cys  Pro Thr Thr 
    1535                 1540                 1545             


Ile Cys  Asp Leu Asp Thr Gln  Phe Arg Cys Gln Glu  Ser Gly Thr 
    1550                 1555                 1560             


Cys Ile  Pro Leu Ser Tyr Lys  Cys Asp Leu Glu Asp  Asp Cys Gly 
    1565                 1570                 1575             


Asp Asn  Ser Asp Glu Ser His  Cys Glu Met His Gln  Cys Arg Ser 
    1580                 1585                 1590             


Asp Glu  Tyr Asn Cys Ser Ser  Gly Met Cys Ile Arg  Ser Ser Trp 
    1595                 1600                 1605             


Val Cys  Asp Gly Asp Asn Asp  Cys Arg Asp Trp Ser  Asp Glu Ala 
    1610                 1615                 1620             


Asn Cys  Thr Ala Ile Tyr His  Thr Cys Glu Ala Ser  Asn Phe Gln 
    1625                 1630                 1635             


Cys Arg  Asn Gly His Cys Ile  Pro Gln Arg Trp Ala  Cys Asp Gly 
    1640                 1645                 1650             


Asp Thr  Asp Cys Gln Asp Gly  Ser Asp Glu Asp Pro  Val Asn Cys 
    1655                 1660                 1665             


Glu Lys  Lys Cys Asn Gly Phe  Arg Cys Pro Asn Gly  Thr Cys Ile 
    1670                 1675                 1680             


Pro Ser  Ser Lys His Cys Asp  Gly Leu Arg Asp Cys  Ser Asp Gly 
    1685                 1690                 1695             


Ser Asp  Glu Gln His Cys Glu  Pro Leu Cys Thr His  Phe Met Asp 
    1700                 1705                 1710             


Phe Val  Cys Lys Asn Arg Gln  Gln Cys Leu Phe His  Ser Met Val 
    1715                 1720                 1725             


Cys Asp  Gly Ile Ile Gln Cys  Arg Asp Gly Ser Asp  Glu Asp Ala 
    1730                 1735                 1740             


Ala Phe  Ala Gly Cys Ser Gln  Asp Pro Glu Phe His  Lys Val Cys 
    1745                 1750                 1755             


Asp Glu  Phe Gly Phe Gln Cys  Gln Asn Gly Val Cys  Ile Ser Leu 
    1760                 1765                 1770             


Ile Trp  Lys Cys Asp Gly Met  Asp Asp Cys Gly Asp  Tyr Ser Asp 
    1775                 1780                 1785             


Glu Ala  Asn Cys Glu Asn Pro  Thr Glu Ala Pro Asn  Cys Ser Arg 
    1790                 1795                 1800             


Tyr Phe  Gln Phe Arg Cys Glu  Asn Gly His Cys Ile  Pro Asn Arg 
    1805                 1810                 1815             


Trp Lys  Cys Asp Arg Glu Asn  Asp Cys Gly Asp Trp  Ser Asp Glu 
    1820                 1825                 1830             


Lys Asp  Cys Gly Asp Ser His  Ile Leu Pro Phe Ser  Thr Pro Gly 
    1835                 1840                 1845             


Pro Ser  Thr Cys Leu Pro Asn  Tyr Tyr Arg Cys Ser  Ser Gly Thr 
    1850                 1855                 1860             


Cys Val  Met Asp Thr Trp Val  Cys Asp Gly Tyr Arg  Asp Cys Ala 
    1865                 1870                 1875             


Asp Gly  Ser Asp Glu Glu Ala  Cys Pro Leu Leu Ala  Asn Val Thr 
    1880                 1885                 1890             


Ala Ala  Ser Thr Pro Thr Gln  Leu Gly Arg Cys Asp  Arg Phe Glu 
    1895                 1900                 1905             


Phe Glu  Cys His Gln Pro Lys  Thr Cys Ile Pro Asn  Trp Lys Arg 
    1910                 1915                 1920             


Cys Asp  Gly His Gln Asp Cys  Gln Asp Gly Arg Asp  Glu Ala Asn 
    1925                 1930                 1935             


Cys Pro  Thr His Ser Thr Leu  Thr Cys Met Ser Arg  Glu Phe Gln 
    1940                 1945                 1950             


Cys Glu  Asp Gly Glu Ala Cys  Ile Val Leu Ser Glu  Arg Cys Asp 
    1955                 1960                 1965             


Gly Phe  Leu Asp Cys Ser Asp  Glu Ser Asp Glu Lys  Ala Cys Ser 
    1970                 1975                 1980             


Asp Glu  Leu Thr Val Tyr Lys  Val Gln Asn Leu Gln  Trp Thr Ala 
    1985                 1990                 1995             


Asp Phe  Ser Gly Asp Val Thr  Leu Thr Trp Met Arg  Pro Lys Lys 
    2000                 2005                 2010             


Met Pro  Ser Ala Ser Cys Val  Tyr Asn Val Tyr Tyr  Arg Val Val 
    2015                 2020                 2025             


Gly Glu  Ser Ile Trp Lys Thr  Leu Glu Thr His Ser  Asn Lys Thr 
    2030                 2035                 2040             


Asn Thr  Val Leu Lys Val Leu  Lys Pro Asp Thr Thr  Tyr Gln Val 
    2045                 2050                 2055             


Lys Val  Gln Val Gln Cys Leu  Ser Lys Ala His Asn  Thr Asn Asp 
    2060                 2065                 2070             


Phe Val  Thr Leu Arg Thr Pro  Glu Gly Leu Pro Asp  Ala Pro Arg 
    2075                 2080                 2085             


Asn Leu  Gln Leu Ser Leu Pro  Arg Glu Ala Glu Gly  Val Ile Val 
    2090                 2095                 2100             


Gly His  Trp Ala Pro Pro Ile  His Thr His Gly Leu  Ile Arg Glu 
    2105                 2110                 2115             


Tyr Ile  Val Glu Tyr Ser Arg  Ser Gly Ser Lys Met  Trp Ala Ser 
    2120                 2125                 2130             


Gln Arg  Ala Ala Ser Asn Phe  Thr Glu Ile Lys Asn  Leu Leu Val 
    2135                 2140                 2145             


Asn Thr  Leu Tyr Thr Val Arg  Val Ala Ala Val Thr  Ser Arg Gly 
    2150                 2155                 2160             


Ile Gly  Asn Trp Ser Asp Ser  Lys Ser Ile Thr Thr  Ile Lys Gly 
    2165                 2170                 2175             


Lys Val  Ile Pro Pro Pro Asp  Ile His Ile Asp Ser  Tyr Gly Glu 
    2180                 2185                 2190             


Asn Tyr  Leu Ser Phe Thr Leu  Thr Met Glu Ser Asp  Ile Lys Val 
    2195                 2200                 2205             


Asn Gly  Tyr Val Val Asn Leu  Phe Trp Ala Phe Asp  Thr His Lys 
    2210                 2215                 2220             


Gln Glu  Arg Arg Thr Leu Asn  Phe Arg Gly Ser Ile  Leu Ser His 
    2225                 2230                 2235             


Lys Val  Gly Asn Leu Thr Ala  His Thr Ser Tyr Glu  Ile Ser Ala 
    2240                 2245                 2250             


Trp Ala  Lys Thr Asp Leu Gly  Asp Ser Pro Leu Ala  Phe Glu His 
    2255                 2260                 2265             


Val Met  Thr Arg Gly Val Arg  Pro Pro Ala Pro Ser  Leu Lys Ala 
    2270                 2275                 2280             


Lys Ala  Ile Asn Gln Thr Ala  Val Glu Cys Thr Trp  Thr Gly Pro 
    2285                 2290                 2295             


Arg Asn  Val Val Tyr Gly Ile  Phe Tyr Ala Thr Ser  Phe Leu Asp 
    2300                 2305                 2310             


Leu Tyr  Arg Asn Pro Lys Ser  Leu Thr Thr Ser Leu  His Asn Lys 
    2315                 2320                 2325             


Thr Val  Ile Val Ser Lys Asp  Glu Gln Tyr Leu Phe  Leu Val Arg 
    2330                 2335                 2340             


Val Val  Val Pro Tyr Gln Gly  Pro Ser Ser Asp Tyr  Val Val Val 
    2345                 2350                 2355             


Lys Met  Ile Pro Asp Ser Arg  Leu Pro Pro Arg His  Leu His Val 
    2360                 2365                 2370             


Val His  Thr Gly Lys Thr Ser  Val Val Ile Lys Trp  Glu Ser Pro 
    2375                 2380                 2385             


Tyr Asp  Ser Pro Asp Gln Asp  Leu Leu Tyr Ala Val  Ala Val Lys 
    2390                 2395                 2400             


Asp Leu  Ile Arg Lys Thr Asp  Arg Ser Tyr Lys Val  Lys Ser Arg 
    2405                 2410                 2415             


Asn Ser  Thr Val Glu Tyr Thr  Leu Asn Lys Leu Glu  Pro Gly Gly 
    2420                 2425                 2430             


Lys Tyr  His Ile Ile Val Gln  Leu Gly Asn Met Ser  Lys Asp Ser 
    2435                 2440                 2445             


Ser Ile  Lys Ile Thr Thr Val  Ser Leu Ser Ala Pro  Asp Ala Leu 
    2450                 2455                 2460             


Lys Ile  Ile Thr Glu Asn Asp  His Val Leu Leu Phe  Trp Lys Ser 
    2465                 2470                 2475             


Leu Ala  Leu Lys Glu Lys His  Phe Asn Glu Ser Arg  Gly Tyr Glu 
    2480                 2485                 2490             


Ile His  Met Phe Asp Ser Ala  Met Asn Ile Thr Ala  Tyr Leu Gly 
    2495                 2500                 2505             


Asn Thr  Thr Asp Asn Phe Phe  Lys Ile Ser Asn Leu  Lys Met Gly 
    2510                 2515                 2520             


His Asn  Tyr Thr Phe Thr Val  Gln Ala Arg Cys Leu  Phe Gly Asn 
    2525                 2530                 2535             


Gln Ile  Cys Gly Glu Pro Ala  Ile Leu Leu Tyr Asp  Glu Leu Gly 
    2540                 2545                 2550             


Ser Gly  Ala Asp Ala Ser Ala  Thr Gln Ala Ala Arg  Ser Thr Asp 
    2555                 2560                 2565             


Val Ala  Ala Val Val Val Pro  Ile Leu Phe Leu Ile  Leu Leu Ser 
    2570                 2575                 2580             


Leu Gly  Val Gly Phe Ala Ile  Leu Tyr Thr Lys His  Arg Arg Leu 
    2585                 2590                 2595             


Gln Ser  Ser Phe Thr Ala Phe  Ala Asn Ser His Tyr  Ser Ser Arg 
    2600                 2605                 2610             


Leu Gly  Ser Ala Ile Phe Ser  Ser Gly Asp Asp Leu  Gly Glu Asp 
    2615                 2620                 2625             


Asp Glu  Asp Ala Pro Met Ile  Thr Gly Phe Ser Asp  Asp Val Pro 
    2630                 2635                 2640             


Met Val  Ile Ala 
    2645         


<210>  4
<211>  2692
<212>  PRT
<213>  Artificial

<220>
<223>  sorLA-reporter construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2692)
<223>  sorLA-reporter construct

<400>  4

Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu 
            20                  25                  30          


Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr 
        35                  40                  45              


Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser 
    50                  55                  60                  


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu 
65                  70                  75                  80  


Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu 
                85                  90                  95      


Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr 
            100                 105                 110         


Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly 
        115                 120                 125             


Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn 
    130                 135                 140                 


Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val 
145                 150                 155                 160 


Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr 
                165                 170                 175     


Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro 
            180                 185                 190         


Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile 
        195                 200                 205             


Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met 
    210                 215                 220                 


Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln 
225                 230                 235                 240 


Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala 
                245                 250                 255     


Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln 
            260                 265                 270         


Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro 
        275                 280                 285             


Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser 
    290                 295                 300                 


Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro 
305                 310                 315                 320 


Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His 
                325                 330                 335     


His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp 
            340                 345                 350         


Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu 
        355                 360                 365             


Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr 
    370                 375                 380                 


Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg 
385                 390                 395                 400 


Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr 
                405                 410                 415     


Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly 
            420                 425                 430         


Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr 
        435                 440                 445             


His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His 
    450                 455                 460                 


Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala 
465                 470                 475                 480 


Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro 
                485                 490                 495     


Ala Gly Thr Thr Asp Ala Ala His Pro Gly Glu Val Trp Thr Gln Arg 
            500                 505                 510         


Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe Leu Val 
        515                 520                 525             


Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly Asp Ala 
    530                 535                 540                 


Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Gly Ser Gly Ser Ser 
545                 550                 555                 560 


Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val Ser Leu 
                565                 570                 575     


Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu Lys Ser 
            580                 585                 590         


Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala Arg Pro 
        595                 600                 605             


Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser Phe Lys 
    610                 615                 620                 


Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser Glu Ala 
625                 630                 635                 640 


Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg Tyr Ile 
                645                 650                 655     


Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp Phe Cys 
            660                 665                 670         


Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp Leu Leu 
        675                 680                 685             


Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg Ser His 
    690                 695                 700                 


Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr Trp Ile 
705                 710                 715                 720 


Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp Pro Tyr 
                725                 730                 735     


Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser Gly Tyr 
            740                 745                 750         


Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu Asn Gln 
        755                 760                 765             


Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp Lys Tyr 
    770                 775                 780                 


Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln Gln Ser 
785                 790                 795                 800 


Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg Ala Ala 
                805                 810                 815     


Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala Asp Ala 
            820                 825                 830         


Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn Arg Thr 
        835                 840                 845             


Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu Ser Leu 
    850                 855                 860                 


Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp Thr Leu 
865                 870                 875                 880 


Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg Val Glu 
                885                 890                 895     


Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser Met Asn 
            900                 905                 910         


Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly Thr Trp 
        915                 920                 925             


Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys Ile Asn 
    930                 935                 940                 


Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg Leu Ser 
945                 950                 955                 960 


Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser Lys Glu 
                965                 970                 975     


Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys Asn Leu 
            980                 985                 990         


Ala Ser Lys Thr Asn Val Tyr Ile  Ser Ser Ser Ala Gly  Ala Arg Trp 
        995                 1000                 1005             


Arg Glu  Ala Leu Pro Gly Pro  His Tyr Tyr Thr Trp  Gly Asp His 
    1010                 1015                 1020             


Gly Gly  Ile Ile Thr Ala Ile  Ala Gln Gly Met Glu  Thr Asn Glu 
    1025                 1030                 1035             


Leu Lys  Tyr Ser Thr Asn Glu  Gly Glu Thr Trp Lys  Thr Phe Ile 
    1040                 1045                 1050             


Phe Ser  Glu Lys Pro Val Phe  Val Tyr Gly Leu Leu  Thr Glu Pro 
    1055                 1060                 1065             


Gly Glu  Lys Ser Thr Val Phe  Thr Ile Phe Gly Ser  Asn Lys Glu 
    1070                 1075                 1080             


Asn Val  His Ser Trp Leu Ile  Leu Gln Val Asn Ala  Thr Asp Ala 
    1085                 1090                 1095             


Leu Gly  Val Pro Cys Thr Glu  Asn Asp Tyr Lys Leu  Trp Ser Pro 
    1100                 1105                 1110             


Ser Asp  Glu Arg Gly Asn Glu  Cys Leu Leu Gly His  Lys Thr Val 
    1115                 1120                 1125             


Phe Lys  Arg Arg Thr Pro His  Ala Thr Cys Phe Asn  Gly Glu Asp 
    1130                 1135                 1140             


Phe Asp  Arg Pro Val Val Val  Ser Asn Cys Ser Cys  Thr Arg Glu 
    1145                 1150                 1155             


Asp Tyr  Glu Cys Asp Phe Gly  Phe Lys Met Ser Glu  Asp Leu Ser 
    1160                 1165                 1170             


Leu Glu  Val Cys Val Pro Asp  Pro Glu Phe Ser Gly  Lys Ser Tyr 
    1175                 1180                 1185             


Ser Pro  Pro Val Pro Cys Pro  Val Gly Ser Thr Tyr  Arg Arg Thr 
    1190                 1195                 1200             


Arg Gly  Tyr Arg Lys Ile Ser  Gly Asp Thr Cys Ser  Gly Gly Asp 
    1205                 1210                 1215             


Val Glu  Ala Arg Leu Glu Gly  Glu Leu Val Pro Cys  Pro Leu Ala 
    1220                 1225                 1230             


Glu Glu  Asn Glu Phe Ile Leu  Tyr Ala Val Arg Lys  Ser Ile Tyr 
    1235                 1240                 1245             


Arg Tyr  Asp Leu Ala Ser Gly  Ala Thr Glu Gln Leu  Pro Leu Thr 
    1250                 1255                 1260             


Gly Leu  Arg Ala Ala Val Ala  Leu Asp Phe Asp Tyr  Glu His Asn 
    1265                 1270                 1275             


Cys Leu  Tyr Trp Ser Asp Leu  Ala Leu Asp Val Ile  Gln Arg Leu 
    1280                 1285                 1290             


Cys Leu  Asn Gly Ser Thr Gly  Gln Glu Val Ile Ile  Asn Ser Gly 
    1295                 1300                 1305             


Leu Glu  Thr Val Glu Ala Leu  Ala Phe Glu Pro Leu  Ser Gln Leu 
    1310                 1315                 1320             


Leu Tyr  Trp Val Asp Ala Gly  Phe Lys Lys Ile Glu  Val Ala Asn 
    1325                 1330                 1335             


Pro Asp  Gly Asp Phe Arg Leu  Thr Ile Val Asn Ser  Ser Val Leu 
    1340                 1345                 1350             


Asp Arg  Pro Arg Ala Leu Val  Leu Val Pro Gln Glu  Gly Val Met 
    1355                 1360                 1365             


Phe Trp  Thr Asp Trp Gly Asp  Leu Lys Pro Gly Ile  Tyr Arg Ser 
    1370                 1375                 1380             


Asn Met  Asp Gly Ser Ala Ala  Tyr His Leu Val Ser  Glu Asp Val 
    1385                 1390                 1395             


Lys Trp  Pro Asn Gly Ile Ser  Val Asp Asp Gln Trp  Ile Tyr Trp 
    1400                 1405                 1410             


Thr Asp  Ala Tyr Leu Glu Cys  Ile Glu Arg Ile Thr  Phe Ser Gly 
    1415                 1420                 1425             


Gln Gln  Arg Ser Val Ile Leu  Asp Asn Leu Pro His  Pro Tyr Ala 
    1430                 1435                 1440             


Ile Ala  Val Phe Lys Asn Glu  Ile Tyr Trp Asp Asp  Trp Ser Gln 
    1445                 1450                 1455             


Leu Ser  Ile Phe Arg Ala Ser  Lys Tyr Ser Gly Ser  Gln Met Glu 
    1460                 1465                 1470             


Ile Leu  Ala Asn Gln Leu Thr  Gly Leu Met Asp Met  Lys Ile Phe 
    1475                 1480                 1485             


Tyr Lys  Gly Lys Asn Thr Gly  Ser Asn Ala Cys Val  Pro Arg Pro 
    1490                 1495                 1500             


Cys Ser  Leu Leu Cys Leu Pro  Lys Ala Asn Asn Ser  Arg Ser Cys 
    1505                 1510                 1515             


Arg Cys  Pro Glu Asp Val Ser  Ser Ser Val Leu Pro  Ser Gly Asp 
    1520                 1525                 1530             


Leu Met  Cys Asp Cys Pro Gln  Gly Tyr Gln Leu Lys  Asn Asn Thr 
    1535                 1540                 1545             


Cys Val  Lys Gln Glu Asn Thr  Cys Leu Arg Asn Gln  Tyr Arg Cys 
    1550                 1555                 1560             


Ser Asn  Gly Asn Cys Ile Asn  Ser Ile Trp Trp Cys  Asp Phe Asp 
    1565                 1570                 1575             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Arg Asn Cys  Pro Thr Thr 
    1580                 1585                 1590             


Ile Cys  Asp Leu Asp Thr Gln  Phe Arg Cys Gln Glu  Ser Gly Thr 
    1595                 1600                 1605             


Cys Ile  Pro Leu Ser Tyr Lys  Cys Asp Leu Glu Asp  Asp Cys Gly 
    1610                 1615                 1620             


Asp Asn  Ser Asp Glu Ser His  Cys Glu Met His Gln  Cys Arg Ser 
    1625                 1630                 1635             


Asp Glu  Tyr Asn Cys Ser Ser  Gly Met Cys Ile Arg  Ser Ser Trp 
    1640                 1645                 1650             


Val Cys  Asp Gly Asp Asn Asp  Cys Arg Asp Trp Ser  Asp Glu Ala 
    1655                 1660                 1665             


Asn Cys  Thr Ala Ile Tyr His  Thr Cys Glu Ala Ser  Asn Phe Gln 
    1670                 1675                 1680             


Cys Arg  Asn Gly His Cys Ile  Pro Gln Arg Trp Ala  Cys Asp Gly 
    1685                 1690                 1695             


Asp Thr  Asp Cys Gln Asp Gly  Ser Asp Glu Asp Pro  Val Asn Cys 
    1700                 1705                 1710             


Glu Lys  Lys Cys Asn Gly Phe  Arg Cys Pro Asn Gly  Thr Cys Ile 
    1715                 1720                 1725             


Pro Ser  Ser Lys His Cys Asp  Gly Leu Arg Asp Cys  Ser Asp Gly 
    1730                 1735                 1740             


Ser Asp  Glu Gln His Cys Glu  Pro Leu Cys Thr His  Phe Met Asp 
    1745                 1750                 1755             


Phe Val  Cys Lys Asn Arg Gln  Gln Cys Leu Phe His  Ser Met Val 
    1760                 1765                 1770             


Cys Asp  Gly Ile Ile Gln Cys  Arg Asp Gly Ser Asp  Glu Asp Ala 
    1775                 1780                 1785             


Ala Phe  Ala Gly Cys Ser Gln  Asp Pro Glu Phe His  Lys Val Cys 
    1790                 1795                 1800             


Asp Glu  Phe Gly Phe Gln Cys  Gln Asn Gly Val Cys  Ile Ser Leu 
    1805                 1810                 1815             


Ile Trp  Lys Cys Asp Gly Met  Asp Asp Cys Gly Asp  Tyr Ser Asp 
    1820                 1825                 1830             


Glu Ala  Asn Cys Glu Asn Pro  Thr Glu Ala Pro Asn  Cys Ser Arg 
    1835                 1840                 1845             


Tyr Phe  Gln Phe Arg Cys Glu  Asn Gly His Cys Ile  Pro Asn Arg 
    1850                 1855                 1860             


Trp Lys  Cys Asp Arg Glu Asn  Asp Cys Gly Asp Trp  Ser Asp Glu 
    1865                 1870                 1875             


Lys Asp  Cys Gly Asp Ser His  Ile Leu Pro Phe Ser  Thr Pro Gly 
    1880                 1885                 1890             


Pro Ser  Thr Cys Leu Pro Asn  Tyr Tyr Arg Cys Ser  Ser Gly Thr 
    1895                 1900                 1905             


Cys Val  Met Asp Thr Trp Val  Cys Asp Gly Tyr Arg  Asp Cys Ala 
    1910                 1915                 1920             


Asp Gly  Ser Asp Glu Glu Ala  Cys Pro Leu Leu Ala  Asn Val Thr 
    1925                 1930                 1935             


Ala Ala  Ser Thr Pro Thr Gln  Leu Gly Arg Cys Asp  Arg Phe Glu 
    1940                 1945                 1950             


Phe Glu  Cys His Gln Pro Lys  Thr Cys Ile Pro Asn  Trp Lys Arg 
    1955                 1960                 1965             


Cys Asp  Gly His Gln Asp Cys  Gln Asp Gly Arg Asp  Glu Ala Asn 
    1970                 1975                 1980             


Cys Pro  Thr His Ser Thr Leu  Thr Cys Met Ser Arg  Glu Phe Gln 
    1985                 1990                 1995             


Cys Glu  Asp Gly Glu Ala Cys  Ile Val Leu Ser Glu  Arg Cys Asp 
    2000                 2005                 2010             


Gly Phe  Leu Asp Cys Ser Asp  Glu Ser Asp Glu Lys  Ala Cys Ser 
    2015                 2020                 2025             


Asp Glu  Leu Thr Val Tyr Lys  Val Gln Asn Leu Gln  Trp Thr Ala 
    2030                 2035                 2040             


Asp Phe  Ser Gly Asp Val Thr  Leu Thr Trp Met Arg  Pro Lys Lys 
    2045                 2050                 2055             


Met Pro  Ser Ala Ser Cys Val  Tyr Asn Val Tyr Tyr  Arg Val Val 
    2060                 2065                 2070             


Gly Glu  Ser Ile Trp Lys Thr  Leu Glu Thr His Ser  Asn Lys Thr 
    2075                 2080                 2085             


Asn Thr  Val Leu Lys Val Leu  Lys Pro Asp Thr Thr  Tyr Gln Val 
    2090                 2095                 2100             


Lys Val  Gln Val Gln Cys Leu  Ser Lys Ala His Asn  Thr Asn Asp 
    2105                 2110                 2115             


Phe Val  Thr Leu Arg Thr Pro  Glu Gly Leu Pro Asp  Ala Pro Arg 
    2120                 2125                 2130             


Asn Leu  Gln Leu Ser Leu Pro  Arg Glu Ala Glu Gly  Val Ile Val 
    2135                 2140                 2145             


Gly His  Trp Ala Pro Pro Ile  His Thr His Gly Leu  Ile Arg Glu 
    2150                 2155                 2160             


Tyr Ile  Val Glu Tyr Ser Arg  Ser Gly Ser Lys Met  Trp Ala Ser 
    2165                 2170                 2175             


Gln Arg  Ala Ala Ser Asn Phe  Thr Glu Ile Lys Asn  Leu Leu Val 
    2180                 2185                 2190             


Asn Thr  Leu Tyr Thr Val Arg  Val Ala Ala Val Thr  Ser Arg Gly 
    2195                 2200                 2205             


Ile Gly  Asn Trp Ser Asp Ser  Lys Ser Ile Thr Thr  Ile Lys Gly 
    2210                 2215                 2220             


Lys Val  Ile Pro Pro Pro Asp  Ile His Ile Asp Ser  Tyr Gly Glu 
    2225                 2230                 2235             


Asn Tyr  Leu Ser Phe Thr Leu  Thr Met Glu Ser Asp  Ile Lys Val 
    2240                 2245                 2250             


Asn Gly  Tyr Val Val Asn Leu  Phe Trp Ala Phe Asp  Thr His Lys 
    2255                 2260                 2265             


Gln Glu  Arg Arg Thr Leu Asn  Phe Arg Gly Ser Ile  Leu Ser His 
    2270                 2275                 2280             


Lys Val  Gly Asn Leu Thr Ala  His Thr Ser Tyr Glu  Ile Ser Ala 
    2285                 2290                 2295             


Trp Ala  Lys Thr Asp Leu Gly  Asp Ser Pro Leu Ala  Phe Glu His 
    2300                 2305                 2310             


Val Met  Thr Arg Gly Val Arg  Pro Pro Ala Pro Ser  Leu Lys Ala 
    2315                 2320                 2325             


Lys Ala  Ile Asn Gln Thr Ala  Val Glu Cys Thr Trp  Thr Gly Pro 
    2330                 2335                 2340             


Arg Asn  Val Val Tyr Gly Ile  Phe Tyr Ala Thr Ser  Phe Leu Asp 
    2345                 2350                 2355             


Leu Tyr  Arg Asn Pro Lys Ser  Leu Thr Thr Ser Leu  His Asn Lys 
    2360                 2365                 2370             


Thr Val  Ile Val Ser Lys Asp  Glu Gln Tyr Leu Phe  Leu Val Arg 
    2375                 2380                 2385             


Val Val  Val Pro Tyr Gln Gly  Pro Ser Ser Asp Tyr  Val Val Val 
    2390                 2395                 2400             


Lys Met  Ile Pro Asp Ser Arg  Leu Pro Pro Arg His  Leu His Val 
    2405                 2410                 2415             


Val His  Thr Gly Lys Thr Ser  Val Val Ile Lys Trp  Glu Ser Pro 
    2420                 2425                 2430             


Tyr Asp  Ser Pro Asp Gln Asp  Leu Leu Tyr Ala Val  Ala Val Lys 
    2435                 2440                 2445             


Asp Leu  Ile Arg Lys Thr Asp  Arg Ser Tyr Lys Val  Lys Ser Arg 
    2450                 2455                 2460             


Asn Ser  Thr Val Glu Tyr Thr  Leu Asn Lys Leu Glu  Pro Gly Gly 
    2465                 2470                 2475             


Lys Tyr  His Ile Ile Val Gln  Leu Gly Asn Met Ser  Lys Asp Ser 
    2480                 2485                 2490             


Ser Ile  Lys Ile Thr Thr Val  Ser Leu Ser Ala Pro  Asp Ala Leu 
    2495                 2500                 2505             


Lys Ile  Ile Thr Glu Asn Asp  His Val Leu Leu Phe  Trp Lys Ser 
    2510                 2515                 2520             


Leu Ala  Leu Lys Glu Lys His  Phe Asn Glu Ser Arg  Gly Tyr Glu 
    2525                 2530                 2535             


Ile His  Met Phe Asp Ser Ala  Met Asn Ile Thr Ala  Tyr Leu Gly 
    2540                 2545                 2550             


Asn Thr  Thr Asp Asn Phe Phe  Lys Ile Ser Asn Leu  Lys Met Gly 
    2555                 2560                 2565             


His Asn  Tyr Thr Phe Thr Val  Gln Ala Arg Cys Leu  Phe Gly Asn 
    2570                 2575                 2580             


Gln Ile  Cys Gly Glu Pro Ala  Ile Leu Leu Tyr Asp  Glu Leu Gly 
    2585                 2590                 2595             


Ser Gly  Ala Asp Ala Ser Ala  Thr Gln Ala Ala Arg  Ser Thr Asp 
    2600                 2605                 2610             


Val Ala  Ala Val Val Val Pro  Ile Leu Phe Leu Ile  Leu Leu Ser 
    2615                 2620                 2625             


Leu Gly  Val Gly Phe Ala Ile  Leu Tyr Thr Lys His  Arg Arg Leu 
    2630                 2635                 2640             


Gln Ser  Ser Phe Thr Ala Phe  Ala Asn Ser His Tyr  Ser Ser Arg 
    2645                 2650                 2655             


Leu Gly  Ser Ala Ile Phe Ser  Ser Gly Asp Asp Leu  Gly Glu Asp 
    2660                 2665                 2670             


Asp Glu  Asp Ala Pro Met Ile  Thr Gly Phe Ser Asp  Asp Val Pro 
    2675                 2680                 2685             


Met Val  Ile Ala 
    2690         


<210>  5
<211>  2639
<212>  PRT
<213>  Artificial

<220>
<223>  sorLA-reporter construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2639)
<223>  sorLA-reporter construct

<400>  5

Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu 
            20                  25                  30          


Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr 
        35                  40                  45              


Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser 
    50                  55                  60                  


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu 
65                  70                  75                  80  


Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu 
                85                  90                  95      


Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr 
            100                 105                 110         


Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly 
        115                 120                 125             


Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn 
    130                 135                 140                 


Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val 
145                 150                 155                 160 


Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr 
                165                 170                 175     


Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro 
            180                 185                 190         


Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile 
        195                 200                 205             


Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met 
    210                 215                 220                 


Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln 
225                 230                 235                 240 


Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala 
                245                 250                 255     


Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln 
            260                 265                 270         


Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro 
        275                 280                 285             


Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser 
    290                 295                 300                 


Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro 
305                 310                 315                 320 


Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His 
                325                 330                 335     


His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp 
            340                 345                 350         


Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu 
        355                 360                 365             


Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr 
    370                 375                 380                 


Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg 
385                 390                 395                 400 


Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr 
                405                 410                 415     


Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly 
            420                 425                 430         


Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr 
        435                 440                 445             


His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His 
    450                 455                 460                 


Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala 
465                 470                 475                 480 


Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro 
                485                 490                 495     


Ala Gly Thr Thr Asp Ala Ala His Pro Gly Ser Ala Ala Leu Gln Pro 
            500                 505                 510         


Glu Pro Ile Lys Val Tyr Gly Gln Val Ser Leu Asn Asp Ser His Asn 
        515                 520                 525             


Gln Met Val Val His Trp Ala Gly Glu Lys Ser Asn Val Ile Val Ala 
    530                 535                 540                 


Leu Ala Arg Asp Ser Leu Ala Leu Ala Arg Pro Lys Ser Ser Asp Val 
545                 550                 555                 560 


Tyr Val Ser Tyr Asp Tyr Gly Lys Ser Phe Lys Lys Ile Ser Asp Lys 
                565                 570                 575     


Leu Asn Phe Gly Leu Gly Asn Arg Ser Glu Ala Val Ile Ala Gln Phe 
            580                 585                 590         


Tyr His Ser Pro Ala Asp Asn Lys Arg Tyr Ile Phe Ala Asp Ala Tyr 
        595                 600                 605             


Ala Gln Tyr Leu Trp Ile Thr Phe Asp Phe Cys Asn Thr Leu Gln Gly 
    610                 615                 620                 


Phe Ser Ile Pro Phe Arg Ala Ala Asp Leu Leu Leu His Ser Lys Ala 
625                 630                 635                 640 


Ser Asn Leu Leu Leu Gly Phe Asp Arg Ser His Pro Asn Lys Gln Leu 
                645                 650                 655     


Trp Lys Ser Asp Asp Phe Gly Gln Thr Trp Ile Met Ile Gln Glu His 
            660                 665                 670         


Val Lys Ser Phe Ser Trp Gly Ile Asp Pro Tyr Asp Lys Pro Asn Thr 
        675                 680                 685             


Ile Tyr Ile Glu Arg His Glu Pro Ser Gly Tyr Ser Thr Val Phe Arg 
    690                 695                 700                 


Ser Thr Asp Phe Phe Gln Ser Arg Glu Asn Gln Glu Val Ile Leu Glu 
705                 710                 715                 720 


Glu Val Arg Asp Phe Gln Leu Arg Asp Lys Tyr Met Phe Ala Thr Lys 
                725                 730                 735     


Val Val His Leu Leu Gly Ser Glu Gln Gln Ser Ser Val Gln Leu Trp 
            740                 745                 750         


Val Ser Phe Gly Arg Lys Pro Met Arg Ala Ala Gln Phe Val Thr Arg 
        755                 760                 765             


His Pro Ile Asn Glu Tyr Tyr Ile Ala Asp Ala Ser Glu Asp Gln Val 
    770                 775                 780                 


Phe Val Cys Val Ser His Ser Asn Asn Arg Thr Asn Leu Tyr Ile Ser 
785                 790                 795                 800 


Glu Ala Glu Gly Leu Lys Phe Ser Leu Ser Leu Glu Asn Val Leu Tyr 
                805                 810                 815     


Tyr Ser Pro Gly Gly Ala Gly Ser Asp Thr Leu Val Arg Tyr Phe Ala 
            820                 825                 830         


Asn Glu Pro Phe Ala Asp Phe His Arg Val Glu Gly Leu Gln Gly Val 
        835                 840                 845             


Tyr Ile Ala Thr Leu Ile Asn Gly Ser Met Asn Glu Glu Asn Met Arg 
    850                 855                 860                 


Ser Val Ile Thr Phe Asp Lys Gly Gly Thr Trp Glu Phe Leu Gln Ala 
865                 870                 875                 880 


Pro Ala Phe Thr Gly Tyr Gly Glu Lys Ile Asn Cys Glu Leu Ser Gln 
                885                 890                 895     


Gly Cys Ser Leu His Leu Ala Gln Arg Leu Ser Gln Leu Leu Asn Leu 
            900                 905                 910         


Gln Leu Arg Arg Met Pro Ile Leu Ser Lys Glu Ser Ala Pro Gly Leu 
        915                 920                 925             


Ile Ile Ala Thr Gly Ser Val Gly Lys Asn Leu Ala Ser Lys Thr Asn 
    930                 935                 940                 


Val Tyr Ile Ser Ser Ser Ala Gly Ala Arg Trp Arg Glu Ala Leu Pro 
945                 950                 955                 960 


Gly Pro His Tyr Tyr Thr Trp Gly Asp His Gly Gly Ile Ile Thr Ala 
                965                 970                 975     


Ile Ala Gln Gly Met Glu Thr Asn Glu Leu Lys Tyr Ser Thr Asn Glu 
            980                 985                 990         


Gly Glu Thr Trp Lys Thr Phe Ile  Phe Ser Glu Lys Pro  Val Phe Val 
        995                 1000                 1005             


Tyr Gly  Leu Leu Thr Glu Pro  Gly Glu Lys Ser Thr  Val Phe Thr 
    1010                 1015                 1020             


Ile Phe  Gly Ser Asn Lys Glu  Asn Val His Ser Trp  Leu Ile Leu 
    1025                 1030                 1035             


Gln Val  Asn Ala Thr Asp Ala  Leu Gly Val Pro Cys  Thr Glu Asn 
    1040                 1045                 1050             


Asp Tyr  Lys Leu Trp Ser Pro  Ser Asp Glu Arg Gly  Asn Glu Cys 
    1055                 1060                 1065             


Leu Leu  Gly His Lys Thr Val  Phe Lys Arg Arg Thr  Pro His Ala 
    1070                 1075                 1080             


Thr Cys  Phe Asn Gly Glu Asp  Phe Asp Arg Pro Val  Val Val Ser 
    1085                 1090                 1095             


Asn Cys  Ser Cys Thr Arg Glu  Asp Tyr Glu Cys Asp  Phe Gly Phe 
    1100                 1105                 1110             


Lys Met  Ser Glu Asp Leu Ser  Leu Glu Val Cys Val  Pro Asp Pro 
    1115                 1120                 1125             


Glu Phe  Ser Gly Lys Ser Tyr  Ser Pro Pro Val Pro  Cys Pro Val 
    1130                 1135                 1140             


Gly Ser  Thr Tyr Arg Arg Thr  Arg Gly Tyr Arg Lys  Ile Ser Gly 
    1145                 1150                 1155             


Asp Thr  Cys Ser Gly Gly Asp  Val Glu Ala Arg Leu  Glu Gly Glu 
    1160                 1165                 1170             


Leu Val  Pro Cys Pro Leu Ala  Glu Glu Asn Glu Phe  Ile Leu Tyr 
    1175                 1180                 1185             


Ala Val  Arg Lys Ser Ile Tyr  Arg Tyr Asp Leu Ala  Ser Gly Ala 
    1190                 1195                 1200             


Thr Glu  Gln Leu Pro Leu Thr  Gly Leu Arg Ala Ala  Val Ala Leu 
    1205                 1210                 1215             


Asp Phe  Asp Tyr Glu His Asn  Cys Leu Tyr Trp Ser  Asp Leu Ala 
    1220                 1225                 1230             


Leu Asp  Val Ile Gln Arg Leu  Cys Leu Asn Gly Ser  Thr Gly Gln 
    1235                 1240                 1245             


Glu Val  Ile Ile Asn Ser Gly  Leu Glu Thr Val Glu  Ala Leu Ala 
    1250                 1255                 1260             


Phe Glu  Pro Leu Ser Gln Leu  Leu Tyr Trp Val Asp  Ala Gly Phe 
    1265                 1270                 1275             


Lys Lys  Ile Glu Val Ala Asn  Pro Asp Gly Asp Phe  Arg Leu Thr 
    1280                 1285                 1290             


Ile Val  Asn Ser Ser Val Leu  Asp Arg Pro Arg Ala  Leu Val Leu 
    1295                 1300                 1305             


Val Pro  Gln Glu Gly Val Met  Phe Trp Thr Asp Trp  Gly Asp Leu 
    1310                 1315                 1320             


Lys Pro  Gly Ile Tyr Arg Ser  Asn Met Asp Gly Ser  Ala Ala Tyr 
    1325                 1330                 1335             


His Leu  Val Ser Glu Asp Val  Lys Trp Pro Asn Gly  Ile Ser Val 
    1340                 1345                 1350             


Asp Asp  Gln Trp Ile Tyr Trp  Thr Asp Ala Tyr Leu  Glu Cys Ile 
    1355                 1360                 1365             


Glu Arg  Ile Thr Phe Ser Gly  Gln Gln Arg Ser Val  Ile Leu Asp 
    1370                 1375                 1380             


Asn Leu  Pro His Pro Tyr Ala  Ile Ala Val Phe Lys  Asn Glu Ile 
    1385                 1390                 1395             


Tyr Trp  Asp Asp Trp Ser Gln  Leu Ser Ile Phe Arg  Ala Ser Lys 
    1400                 1405                 1410             


Tyr Ser  Gly Ser Gln Met Glu  Ile Leu Ala Asn Gln  Leu Thr Gly 
    1415                 1420                 1425             


Leu Met  Asp Met Lys Ile Phe  Tyr Lys Gly Lys Asn  Thr Gly Ser 
    1430                 1435                 1440             


Asn Ala  Cys Val Pro Arg Pro  Cys Ser Leu Leu Cys  Leu Pro Lys 
    1445                 1450                 1455             


Ala Asn  Asn Ser Arg Ser Cys  Arg Cys Pro Glu Asp  Val Ser Ser 
    1460                 1465                 1470             


Ser Val  Leu Pro Ser Gly Asp  Leu Met Cys Asp Cys  Pro Gln Gly 
    1475                 1480                 1485             


Tyr Gln  Leu Lys Asn Asn Thr  Cys Val Lys Gln Glu  Asn Thr Cys 
    1490                 1495                 1500             


Leu Arg  Asn Gln Tyr Arg Cys  Ser Asn Gly Asn Cys  Ile Asn Ser 
    1505                 1510                 1515             


Ile Trp  Trp Cys Asp Phe Asp  Asn Asp Cys Gly Asp  Met Ser Asp 
    1520                 1525                 1530             


Glu Arg  Asn Cys Pro Thr Thr  Ile Cys Asp Leu Asp  Thr Gln Phe 
    1535                 1540                 1545             


Arg Cys  Gln Glu Ser Gly Thr  Cys Ile Pro Leu Ser  Tyr Lys Cys 
    1550                 1555                 1560             


Asp Leu  Glu Asp Asp Cys Gly  Asp Asn Ser Asp Glu  Ser His Cys 
    1565                 1570                 1575             


Glu Met  His Gln Cys Arg Ser  Asp Glu Tyr Asn Cys  Ser Ser Gly 
    1580                 1585                 1590             


Met Cys  Ile Arg Ser Ser Trp  Val Cys Asp Gly Asp  Asn Asp Cys 
    1595                 1600                 1605             


Arg Asp  Trp Ser Asp Glu Ala  Asn Cys Thr Ala Ile  Tyr His Thr 
    1610                 1615                 1620             


Cys Glu  Ala Ser Asn Phe Gln  Cys Arg Asn Gly His  Cys Ile Pro 
    1625                 1630                 1635             


Gln Arg  Trp Ala Cys Asp Gly  Asp Thr Asp Cys Gln  Asp Gly Ser 
    1640                 1645                 1650             


Asp Glu  Asp Pro Val Asn Cys  Glu Lys Lys Cys Asn  Gly Phe Arg 
    1655                 1660                 1665             


Cys Pro  Asn Gly Thr Cys Ile  Pro Ser Ser Lys His  Cys Asp Gly 
    1670                 1675                 1680             


Leu Arg  Asp Cys Ser Asp Gly  Ser Asp Glu Gln His  Cys Glu Pro 
    1685                 1690                 1695             


Leu Cys  Thr His Phe Met Asp  Phe Val Cys Lys Asn  Arg Gln Gln 
    1700                 1705                 1710             


Cys Leu  Phe His Ser Met Val  Cys Asp Gly Ile Ile  Gln Cys Arg 
    1715                 1720                 1725             


Asp Gly  Ser Asp Glu Asp Ala  Ala Phe Ala Gly Cys  Ser Gln Asp 
    1730                 1735                 1740             


Pro Glu  Phe His Lys Val Cys  Asp Glu Phe Gly Phe  Gln Cys Gln 
    1745                 1750                 1755             


Asn Gly  Val Cys Ile Ser Leu  Ile Trp Lys Cys Asp  Gly Met Asp 
    1760                 1765                 1770             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Ala Asn Cys Glu  Asn Pro Thr 
    1775                 1780                 1785             


Glu Ala  Pro Asn Cys Ser Arg  Tyr Phe Gln Phe Arg  Cys Glu Asn 
    1790                 1795                 1800             


Gly His  Cys Ile Pro Asn Arg  Trp Lys Cys Asp Arg  Glu Asn Asp 
    1805                 1810                 1815             


Cys Gly  Asp Trp Ser Asp Glu  Lys Asp Cys Gly Asp  Ser His Ile 
    1820                 1825                 1830             


Leu Pro  Phe Ser Thr Pro Gly  Pro Ser Thr Cys Leu  Pro Asn Tyr 
    1835                 1840                 1845             


Tyr Arg  Cys Ser Ser Gly Thr  Cys Val Met Asp Thr  Trp Val Cys 
    1850                 1855                 1860             


Asp Gly  Tyr Arg Asp Cys Ala  Asp Gly Ser Asp Glu  Glu Ala Cys 
    1865                 1870                 1875             


Pro Leu  Leu Ala Asn Val Thr  Ala Ala Ser Thr Pro  Thr Gln Leu 
    1880                 1885                 1890             


Gly Arg  Cys Asp Arg Phe Glu  Phe Glu Cys His Gln  Pro Lys Thr 
    1895                 1900                 1905             


Cys Ile  Pro Asn Trp Lys Arg  Cys Asp Gly His Gln  Asp Cys Gln 
    1910                 1915                 1920             


Asp Gly  Arg Asp Glu Ala Asn  Cys Pro Thr His Ser  Thr Leu Thr 
    1925                 1930                 1935             


Cys Met  Ser Arg Glu Phe Gln  Cys Glu Asp Gly Glu  Ala Cys Ile 
    1940                 1945                 1950             


Val Leu  Ser Glu Arg Cys Asp  Gly Phe Leu Asp Cys  Ser Asp Glu 
    1955                 1960                 1965             


Ser Asp  Glu Lys Ala Cys Ser  Asp Glu Leu Thr Val  Tyr Lys Val 
    1970                 1975                 1980             


Gln Asn  Leu Gln Trp Thr Ala  Asp Phe Ser Gly Asp  Val Thr Leu 
    1985                 1990                 1995             


Thr Trp  Met Arg Pro Lys Lys  Met Pro Ser Ala Ser  Cys Val Tyr 
    2000                 2005                 2010             


Asn Val  Tyr Tyr Arg Val Val  Gly Glu Ser Ile Trp  Lys Thr Leu 
    2015                 2020                 2025             


Glu Thr  His Ser Asn Lys Thr  Asn Thr Val Leu Lys  Val Leu Lys 
    2030                 2035                 2040             


Pro Asp  Thr Thr Tyr Gln Val  Lys Val Gln Val Gln  Cys Leu Ser 
    2045                 2050                 2055             


Lys Ala  His Asn Thr Asn Asp  Phe Val Thr Leu Arg  Thr Pro Glu 
    2060                 2065                 2070             


Gly Leu  Pro Asp Ala Pro Arg  Asn Leu Gln Leu Ser  Leu Pro Arg 
    2075                 2080                 2085             


Glu Ala  Glu Gly Val Ile Val  Gly His Trp Ala Pro  Pro Ile His 
    2090                 2095                 2100             


Thr His  Gly Leu Ile Arg Glu  Tyr Ile Val Glu Tyr  Ser Arg Ser 
    2105                 2110                 2115             


Gly Ser  Lys Met Trp Ala Ser  Gln Arg Ala Ala Ser  Asn Phe Thr 
    2120                 2125                 2130             


Glu Ile  Lys Asn Leu Leu Val  Asn Thr Leu Tyr Thr  Val Arg Val 
    2135                 2140                 2145             


Ala Ala  Val Thr Ser Arg Gly  Ile Gly Asn Trp Ser  Asp Ser Lys 
    2150                 2155                 2160             


Ser Ile  Thr Thr Ile Lys Gly  Lys Val Ile Pro Pro  Pro Asp Ile 
    2165                 2170                 2175             


His Ile  Asp Ser Tyr Gly Glu  Asn Tyr Leu Ser Phe  Thr Leu Thr 
    2180                 2185                 2190             


Met Glu  Ser Asp Ile Lys Val  Asn Gly Tyr Val Val  Asn Leu Phe 
    2195                 2200                 2205             


Trp Ala  Phe Asp Thr His Lys  Gln Glu Arg Arg Thr  Leu Asn Phe 
    2210                 2215                 2220             


Arg Gly  Ser Ile Leu Ser His  Lys Val Gly Asn Leu  Thr Ala His 
    2225                 2230                 2235             


Thr Ser  Tyr Glu Ile Ser Ala  Trp Ala Lys Thr Asp  Leu Gly Asp 
    2240                 2245                 2250             


Ser Pro  Leu Ala Phe Glu His  Val Met Thr Arg Gly  Val Arg Pro 
    2255                 2260                 2265             


Pro Ala  Pro Ser Leu Lys Ala  Lys Ala Ile Asn Gln  Thr Ala Val 
    2270                 2275                 2280             


Glu Cys  Thr Trp Thr Gly Pro  Arg Asn Val Val Tyr  Gly Ile Phe 
    2285                 2290                 2295             


Tyr Ala  Thr Ser Phe Leu Asp  Leu Tyr Arg Asn Pro  Lys Ser Leu 
    2300                 2305                 2310             


Thr Thr  Ser Leu His Asn Lys  Thr Val Ile Val Ser  Lys Asp Glu 
    2315                 2320                 2325             


Gln Tyr  Leu Phe Leu Val Arg  Val Val Val Pro Tyr  Gln Gly Pro 
    2330                 2335                 2340             


Ser Ser  Asp Tyr Val Val Val  Lys Met Ile Pro Asp  Ser Arg Leu 
    2345                 2350                 2355             


Pro Pro  Arg His Leu His Val  Val His Thr Gly Lys  Thr Ser Val 
    2360                 2365                 2370             


Val Ile  Lys Trp Glu Ser Pro  Tyr Asp Ser Pro Asp  Gln Asp Leu 
    2375                 2380                 2385             


Leu Tyr  Ala Val Ala Val Lys  Asp Leu Ile Arg Lys  Thr Asp Arg 
    2390                 2395                 2400             


Ser Tyr  Lys Val Lys Ser Arg  Asn Ser Thr Val Glu  Tyr Thr Leu 
    2405                 2410                 2415             


Asn Lys  Leu Glu Pro Gly Gly  Lys Tyr His Ile Ile  Val Gln Leu 
    2420                 2425                 2430             


Gly Asn  Met Ser Lys Asp Ser  Ser Ile Lys Ile Thr  Thr Val Ser 
    2435                 2440                 2445             


Leu Ser  Ala Pro Asp Ala Leu  Lys Ile Ile Thr Glu  Asn Asp His 
    2450                 2455                 2460             


Val Leu  Leu Phe Trp Lys Ser  Leu Ala Leu Lys Glu  Lys His Phe 
    2465                 2470                 2475             


Asn Glu  Ser Arg Gly Tyr Glu  Ile His Met Phe Asp  Ser Ala Met 
    2480                 2485                 2490             


Asn Ile  Thr Ala Tyr Leu Gly  Asn Thr Thr Asp Asn  Phe Phe Lys 
    2495                 2500                 2505             


Ile Ser  Asn Leu Lys Met Gly  His Asn Tyr Thr Phe  Thr Val Gln 
    2510                 2515                 2520             


Ala Arg  Cys Leu Phe Gly Asn  Gln Ile Cys Gly Glu  Pro Ala Ile 
    2525                 2530                 2535             


Leu Leu  Tyr Asp Glu Leu Gly  Ser Gly Ala Asp Ala  Ser Ala Thr 
    2540                 2545                 2550             


Gln Ala  Ala Arg Ser Thr Asp  Val Ala Ala Val Val  Val Pro Ile 
    2555                 2560                 2565             


Leu Phe  Leu Ile Leu Leu Ser  Leu Gly Val Gly Phe  Ala Ile Leu 
    2570                 2575                 2580             


Tyr Thr  Lys His Arg Arg Leu  Gln Ser Ser Phe Thr  Ala Phe Ala 
    2585                 2590                 2595             


Asn Ser  His Tyr Ser Ser Arg  Leu Gly Ser Ala Ile  Phe Ser Ser 
    2600                 2605                 2610             


Gly Asp  Asp Leu Gly Glu Asp  Asp Glu Asp Ala Pro  Met Ile Thr 
    2615                 2620                 2625             


Gly Phe  Ser Asp Asp Val Pro  Met Val Ile Ala 
    2630                 2635                 


<210>  6
<211>  2303
<212>  PRT
<213>  Artificial

<220>
<223>  sorLA-reporter construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2303)
<223>  sorLA-reporter construct

<400>  6

Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala Ser 
1               5                   10                  15      


Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro Gly 
            20                  25                  30          


Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Ile Glu Ala Asn Ala Arg 
        35                  40                  45              


Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile Lys 
    50                  55                  60                  


Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr Tyr 
65                  70                  75                  80  


Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala Ile Val 
                85                  90                  95      


Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro Ile Glu Gln 
            100                 105                 110         


Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr Gly Cys Leu 
        115                 120                 125             


Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys Lys Trp Leu 
    130                 135                 140                 


Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln Val Asp 
145                 150                 155                 160 


Lys Ile Lys Gly Ala Gly Gly Asp Leu Glu Ser Ala Ala Leu Gln Pro 
                165                 170                 175     


Glu Pro Ile Lys Val Tyr Gly Gln Val Ser Leu Asn Asp Ser His Asn 
            180                 185                 190         


Gln Met Val Val His Trp Ala Gly Glu Lys Ser Asn Val Ile Val Ala 
        195                 200                 205             


Leu Ala Arg Asp Ser Leu Ala Leu Ala Arg Pro Lys Ser Ser Asp Val 
    210                 215                 220                 


Tyr Val Ser Tyr Asp Tyr Gly Lys Ser Phe Lys Lys Ile Ser Asp Lys 
225                 230                 235                 240 


Leu Asn Phe Gly Leu Gly Asn Arg Ser Glu Ala Val Ile Ala Gln Phe 
                245                 250                 255     


Tyr His Ser Pro Ala Asp Asn Lys Arg Tyr Ile Phe Ala Asp Ala Tyr 
            260                 265                 270         


Ala Gln Tyr Leu Trp Ile Thr Phe Asp Phe Cys Asn Thr Leu Gln Gly 
        275                 280                 285             


Phe Ser Ile Pro Phe Arg Ala Ala Asp Leu Leu Leu His Ser Lys Ala 
    290                 295                 300                 


Ser Asn Leu Leu Leu Gly Phe Asp Arg Ser His Pro Asn Lys Gln Leu 
305                 310                 315                 320 


Trp Lys Ser Asp Asp Phe Gly Gln Thr Trp Ile Met Ile Gln Glu His 
                325                 330                 335     


Val Lys Ser Phe Ser Trp Gly Ile Asp Pro Tyr Asp Lys Pro Asn Thr 
            340                 345                 350         


Ile Tyr Ile Glu Arg His Glu Pro Ser Gly Tyr Ser Thr Val Phe Arg 
        355                 360                 365             


Ser Thr Asp Phe Phe Gln Ser Arg Glu Asn Gln Glu Val Ile Leu Glu 
    370                 375                 380                 


Glu Val Arg Asp Phe Gln Leu Arg Asp Lys Tyr Met Phe Ala Thr Lys 
385                 390                 395                 400 


Val Val His Leu Leu Gly Ser Glu Gln Gln Ser Ser Val Gln Leu Trp 
                405                 410                 415     


Val Ser Phe Gly Arg Lys Pro Met Arg Ala Ala Gln Phe Val Thr Arg 
            420                 425                 430         


His Pro Ile Asn Glu Tyr Tyr Ile Ala Asp Ala Ser Glu Asp Gln Val 
        435                 440                 445             


Phe Val Cys Val Ser His Ser Asn Asn Arg Thr Asn Leu Tyr Ile Ser 
    450                 455                 460                 


Glu Ala Glu Gly Leu Lys Phe Ser Leu Ser Leu Glu Asn Val Leu Tyr 
465                 470                 475                 480 


Tyr Ser Pro Gly Gly Ala Gly Ser Asp Thr Leu Val Arg Tyr Phe Ala 
                485                 490                 495     


Asn Glu Pro Phe Ala Asp Phe His Arg Val Glu Gly Leu Gln Gly Val 
            500                 505                 510         


Tyr Ile Ala Thr Leu Ile Asn Gly Ser Met Asn Glu Glu Asn Met Arg 
        515                 520                 525             


Ser Val Ile Thr Phe Asp Lys Gly Gly Thr Trp Glu Phe Leu Gln Ala 
    530                 535                 540                 


Pro Ala Phe Thr Gly Tyr Gly Glu Lys Ile Asn Cys Glu Leu Ser Gln 
545                 550                 555                 560 


Gly Cys Ser Leu His Leu Ala Gln Arg Leu Ser Gln Leu Leu Asn Leu 
                565                 570                 575     


Gln Leu Arg Arg Met Pro Ile Leu Ser Lys Glu Ser Ala Pro Gly Leu 
            580                 585                 590         


Ile Ile Ala Thr Gly Ser Val Gly Lys Asn Leu Ala Ser Lys Thr Asn 
        595                 600                 605             


Val Tyr Ile Ser Ser Ser Ala Gly Ala Arg Trp Arg Glu Ala Leu Pro 
    610                 615                 620                 


Gly Pro His Tyr Tyr Thr Trp Gly Asp His Gly Gly Ile Ile Thr Ala 
625                 630                 635                 640 


Ile Ala Gln Gly Met Glu Thr Asn Glu Leu Lys Tyr Ser Thr Asn Glu 
                645                 650                 655     


Gly Glu Thr Trp Lys Thr Phe Ile Phe Ser Glu Lys Pro Val Phe Val 
            660                 665                 670         


Tyr Gly Leu Leu Thr Glu Pro Gly Glu Lys Ser Thr Val Phe Thr Ile 
        675                 680                 685             


Phe Gly Ser Asn Lys Glu Asn Val His Ser Trp Leu Ile Leu Gln Val 
    690                 695                 700                 


Asn Ala Thr Asp Ala Leu Gly Val Pro Cys Thr Glu Asn Asp Tyr Lys 
705                 710                 715                 720 


Leu Trp Ser Pro Ser Asp Glu Arg Gly Asn Glu Cys Leu Leu Gly His 
                725                 730                 735     


Lys Thr Val Phe Lys Arg Arg Thr Pro His Ala Thr Cys Phe Asn Gly 
            740                 745                 750         


Glu Asp Phe Asp Arg Pro Val Val Val Ser Asn Cys Ser Cys Thr Arg 
        755                 760                 765             


Glu Asp Tyr Glu Cys Asp Phe Gly Phe Lys Met Ser Glu Asp Leu Ser 
    770                 775                 780                 


Leu Glu Val Cys Val Pro Asp Pro Glu Phe Ser Gly Lys Ser Tyr Ser 
785                 790                 795                 800 


Pro Pro Val Pro Cys Pro Val Gly Ser Thr Tyr Arg Arg Thr Arg Gly 
                805                 810                 815     


Tyr Arg Lys Ile Ser Gly Asp Thr Cys Ser Gly Gly Asp Val Glu Ala 
            820                 825                 830         


Arg Leu Glu Gly Glu Leu Val Pro Cys Pro Leu Ala Glu Glu Asn Glu 
        835                 840                 845             


Phe Ile Leu Tyr Ala Val Arg Lys Ser Ile Tyr Arg Tyr Asp Leu Ala 
    850                 855                 860                 


Ser Gly Ala Thr Glu Gln Leu Pro Leu Thr Gly Leu Arg Ala Ala Val 
865                 870                 875                 880 


Ala Leu Asp Phe Asp Tyr Glu His Asn Cys Leu Tyr Trp Ser Asp Leu 
                885                 890                 895     


Ala Leu Asp Val Ile Gln Arg Leu Cys Leu Asn Gly Ser Thr Gly Gln 
            900                 905                 910         


Glu Val Ile Ile Asn Ser Gly Leu Glu Thr Val Glu Ala Leu Ala Phe 
        915                 920                 925             


Glu Pro Leu Ser Gln Leu Leu Tyr Trp Val Asp Ala Gly Phe Lys Lys 
    930                 935                 940                 


Ile Glu Val Ala Asn Pro Asp Gly Asp Phe Arg Leu Thr Ile Val Asn 
945                 950                 955                 960 


Ser Ser Val Leu Asp Arg Pro Arg Ala Leu Val Leu Val Pro Gln Glu 
                965                 970                 975     


Gly Val Met Phe Trp Thr Asp Trp Gly Asp Leu Lys Pro Gly Ile Tyr 
            980                 985                 990         


Arg Ser Asn Met Asp Gly Ser Ala  Ala Tyr His Leu Val  Ser Glu Asp 
        995                 1000                 1005             


Val Lys  Trp Pro Asn Gly Ile  Ser Val Asp Asp Gln  Trp Ile Tyr 
    1010                 1015                 1020             


Trp Thr  Asp Ala Tyr Leu Glu  Cys Ile Glu Arg Ile  Thr Phe Ser 
    1025                 1030                 1035             


Gly Gln  Gln Arg Ser Val Ile  Leu Asp Asn Leu Pro  His Pro Tyr 
    1040                 1045                 1050             


Ala Ile  Ala Val Phe Lys Asn  Glu Ile Tyr Trp Asp  Asp Trp Ser 
    1055                 1060                 1065             


Gln Leu  Ser Ile Phe Arg Ala  Ser Lys Tyr Ser Gly  Ser Gln Met 
    1070                 1075                 1080             


Glu Ile  Leu Ala Asn Gln Leu  Thr Gly Leu Met Asp  Met Lys Ile 
    1085                 1090                 1095             


Phe Tyr  Lys Gly Lys Asn Thr  Gly Ser Asn Ala Cys  Val Pro Arg 
    1100                 1105                 1110             


Pro Cys  Ser Leu Leu Cys Leu  Pro Lys Ala Asn Asn  Ser Arg Ser 
    1115                 1120                 1125             


Cys Arg  Cys Pro Glu Asp Val  Ser Ser Ser Val Leu  Pro Ser Gly 
    1130                 1135                 1140             


Asp Leu  Met Cys Asp Cys Pro  Gln Gly Tyr Gln Leu  Lys Asn Asn 
    1145                 1150                 1155             


Thr Cys  Val Lys Gln Glu Asn  Thr Cys Leu Arg Asn  Gln Tyr Arg 
    1160                 1165                 1170             


Cys Ser  Asn Gly Asn Cys Ile  Asn Ser Ile Trp Trp  Cys Asp Phe 
    1175                 1180                 1185             


Asp Asn  Asp Cys Gly Asp Met  Ser Asp Glu Arg Asn  Cys Pro Thr 
    1190                 1195                 1200             


Thr Ile  Cys Asp Leu Asp Thr  Gln Phe Arg Cys Gln  Glu Ser Gly 
    1205                 1210                 1215             


Thr Cys  Ile Pro Leu Ser Tyr  Lys Cys Asp Leu Glu  Asp Asp Cys 
    1220                 1225                 1230             


Gly Asp  Asn Ser Asp Glu Ser  His Cys Glu Met His  Gln Cys Arg 
    1235                 1240                 1245             


Ser Asp  Glu Tyr Asn Cys Ser  Ser Gly Met Cys Ile  Arg Ser Ser 
    1250                 1255                 1260             


Trp Val  Cys Asp Gly Asp Asn  Asp Cys Arg Asp Trp  Ser Asp Glu 
    1265                 1270                 1275             


Ala Asn  Cys Thr Ala Ile Tyr  His Thr Cys Glu Ala  Ser Asn Phe 
    1280                 1285                 1290             


Gln Cys  Arg Asn Gly His Cys  Ile Pro Gln Arg Trp  Ala Cys Asp 
    1295                 1300                 1305             


Gly Asp  Thr Asp Cys Gln Asp  Gly Ser Asp Glu Asp  Pro Val Asn 
    1310                 1315                 1320             


Cys Glu  Lys Lys Cys Asn Gly  Phe Arg Cys Pro Asn  Gly Thr Cys 
    1325                 1330                 1335             


Ile Pro  Ser Ser Lys His Cys  Asp Gly Leu Arg Asp  Cys Ser Asp 
    1340                 1345                 1350             


Gly Ser  Asp Glu Gln His Cys  Glu Pro Leu Cys Thr  His Phe Met 
    1355                 1360                 1365             


Asp Phe  Val Cys Lys Asn Arg  Gln Gln Cys Leu Phe  His Ser Met 
    1370                 1375                 1380             


Val Cys  Asp Gly Ile Ile Gln  Cys Arg Asp Gly Ser  Asp Glu Asp 
    1385                 1390                 1395             


Ala Ala  Phe Ala Gly Cys Ser  Gln Asp Pro Glu Phe  His Lys Val 
    1400                 1405                 1410             


Cys Asp  Glu Phe Gly Phe Gln  Cys Gln Asn Gly Val  Cys Ile Ser 
    1415                 1420                 1425             


Leu Ile  Trp Lys Cys Asp Gly  Met Asp Asp Cys Gly  Asp Tyr Ser 
    1430                 1435                 1440             


Asp Glu  Ala Asn Cys Glu Asn  Pro Thr Glu Ala Pro  Asn Cys Ser 
    1445                 1450                 1455             


Arg Tyr  Phe Gln Phe Arg Cys  Glu Asn Gly His Cys  Ile Pro Asn 
    1460                 1465                 1470             


Arg Trp  Lys Cys Asp Arg Glu  Asn Asp Cys Gly Asp  Trp Ser Asp 
    1475                 1480                 1485             


Glu Lys  Asp Cys Gly Asp Ser  His Ile Leu Pro Phe  Ser Thr Pro 
    1490                 1495                 1500             


Gly Pro  Ser Thr Cys Leu Pro  Asn Tyr Tyr Arg Cys  Ser Ser Gly 
    1505                 1510                 1515             


Thr Cys  Val Met Asp Thr Trp  Val Cys Asp Gly Tyr  Arg Asp Cys 
    1520                 1525                 1530             


Ala Asp  Gly Ser Asp Glu Glu  Ala Cys Pro Leu Leu  Ala Asn Val 
    1535                 1540                 1545             


Thr Ala  Ala Ser Thr Pro Thr  Gln Leu Gly Arg Cys  Asp Arg Phe 
    1550                 1555                 1560             


Glu Phe  Glu Cys His Gln Pro  Lys Thr Cys Ile Pro  Asn Trp Lys 
    1565                 1570                 1575             


Arg Cys  Asp Gly His Gln Asp  Cys Gln Asp Gly Arg  Asp Glu Ala 
    1580                 1585                 1590             


Asn Cys  Pro Thr His Ser Thr  Leu Thr Cys Met Ser  Arg Glu Phe 
    1595                 1600                 1605             


Gln Cys  Glu Asp Gly Glu Ala  Cys Ile Val Leu Ser  Glu Arg Cys 
    1610                 1615                 1620             


Asp Gly  Phe Leu Asp Cys Ser  Asp Glu Ser Asp Glu  Lys Ala Cys 
    1625                 1630                 1635             


Ser Asp  Glu Leu Thr Val Tyr  Lys Val Gln Asn Leu  Gln Trp Thr 
    1640                 1645                 1650             


Ala Asp  Phe Ser Gly Asp Val  Thr Leu Thr Trp Met  Arg Pro Lys 
    1655                 1660                 1665             


Lys Met  Pro Ser Ala Ser Cys  Val Tyr Asn Val Tyr  Tyr Arg Val 
    1670                 1675                 1680             


Val Gly  Glu Ser Ile Trp Lys  Thr Leu Glu Thr His  Ser Asn Lys 
    1685                 1690                 1695             


Thr Asn  Thr Val Leu Lys Val  Leu Lys Pro Asp Thr  Thr Tyr Gln 
    1700                 1705                 1710             


Val Lys  Val Gln Val Gln Cys  Leu Ser Lys Ala His  Asn Thr Asn 
    1715                 1720                 1725             


Asp Phe  Val Thr Leu Arg Thr  Pro Glu Gly Leu Pro  Asp Ala Pro 
    1730                 1735                 1740             


Arg Asn  Leu Gln Leu Ser Leu  Pro Arg Glu Ala Glu  Gly Val Ile 
    1745                 1750                 1755             


Val Gly  His Trp Ala Pro Pro  Ile His Thr His Gly  Leu Ile Arg 
    1760                 1765                 1770             


Glu Tyr  Ile Val Glu Tyr Ser  Arg Ser Gly Ser Lys  Met Trp Ala 
    1775                 1780                 1785             


Ser Gln  Arg Ala Ala Ser Asn  Phe Thr Glu Ile Lys  Asn Leu Leu 
    1790                 1795                 1800             


Val Asn  Thr Leu Tyr Thr Val  Arg Val Ala Ala Val  Thr Ser Arg 
    1805                 1810                 1815             


Gly Ile  Gly Asn Trp Ser Asp  Ser Lys Ser Ile Thr  Thr Ile Lys 
    1820                 1825                 1830             


Gly Lys  Val Ile Pro Pro Pro  Asp Ile His Ile Asp  Ser Tyr Gly 
    1835                 1840                 1845             


Glu Asn  Tyr Leu Ser Phe Thr  Leu Thr Met Glu Ser  Asp Ile Lys 
    1850                 1855                 1860             


Val Asn  Gly Tyr Val Val Asn  Leu Phe Trp Ala Phe  Asp Thr His 
    1865                 1870                 1875             


Lys Gln  Glu Arg Arg Thr Leu  Asn Phe Arg Gly Ser  Ile Leu Ser 
    1880                 1885                 1890             


His Lys  Val Gly Asn Leu Thr  Ala His Thr Ser Tyr  Glu Ile Ser 
    1895                 1900                 1905             


Ala Trp  Ala Lys Thr Asp Leu  Gly Asp Ser Pro Leu  Ala Phe Glu 
    1910                 1915                 1920             


His Val  Met Thr Arg Gly Val  Arg Pro Pro Ala Pro  Ser Leu Lys 
    1925                 1930                 1935             


Ala Lys  Ala Ile Asn Gln Thr  Ala Val Glu Cys Thr  Trp Thr Gly 
    1940                 1945                 1950             


Pro Arg  Asn Val Val Tyr Gly  Ile Phe Tyr Ala Thr  Ser Phe Leu 
    1955                 1960                 1965             


Asp Leu  Tyr Arg Asn Pro Lys  Ser Leu Thr Thr Ser  Leu His Asn 
    1970                 1975                 1980             


Lys Thr  Val Ile Val Ser Lys  Asp Glu Gln Tyr Leu  Phe Leu Val 
    1985                 1990                 1995             


Arg Val  Val Val Pro Tyr Gln  Gly Pro Ser Ser Asp  Tyr Val Val 
    2000                 2005                 2010             


Val Lys  Met Ile Pro Asp Ser  Arg Leu Pro Pro Arg  His Leu His 
    2015                 2020                 2025             


Val Val  His Thr Gly Lys Thr  Ser Val Val Ile Lys  Trp Glu Ser 
    2030                 2035                 2040             


Pro Tyr  Asp Ser Pro Asp Gln  Asp Leu Leu Tyr Ala  Val Ala Val 
    2045                 2050                 2055             


Lys Asp  Leu Ile Arg Lys Thr  Asp Arg Ser Tyr Lys  Val Lys Ser 
    2060                 2065                 2070             


Arg Asn  Ser Thr Val Glu Tyr  Thr Leu Asn Lys Leu  Glu Pro Gly 
    2075                 2080                 2085             


Gly Lys  Tyr His Ile Ile Val  Gln Leu Gly Asn Met  Ser Lys Asp 
    2090                 2095                 2100             


Ser Ser  Ile Lys Ile Thr Thr  Val Ser Leu Ser Ala  Pro Asp Ala 
    2105                 2110                 2115             


Leu Lys  Ile Ile Thr Glu Asn  Asp His Val Leu Leu  Phe Trp Lys 
    2120                 2125                 2130             


Ser Leu  Ala Leu Lys Glu Lys  His Phe Asn Glu Ser  Arg Gly Tyr 
    2135                 2140                 2145             


Glu Ile  His Met Phe Asp Ser  Ala Met Asn Ile Thr  Ala Tyr Leu 
    2150                 2155                 2160             


Gly Asn  Thr Thr Asp Asn Phe  Phe Lys Ile Ser Asn  Leu Lys Met 
    2165                 2170                 2175             


Gly His  Asn Tyr Thr Phe Thr  Val Gln Ala Arg Cys  Leu Phe Gly 
    2180                 2185                 2190             


Asn Gln  Ile Cys Gly Glu Pro  Ala Ile Leu Leu Tyr  Asp Glu Leu 
    2195                 2200                 2205             


Gly Ser  Gly Ala Asp Ala Ser  Ala Thr Gln Ala Ala  Arg Ser Thr 
    2210                 2215                 2220             


Asp Val  Ala Ala Val Val Val  Pro Ile Leu Phe Leu  Ile Leu Leu 
    2225                 2230                 2235             


Ser Leu  Gly Val Gly Phe Ala  Ile Leu Tyr Thr Lys  His Arg Arg 
    2240                 2245                 2250             


Leu Gln  Ser Ser Phe Thr Ala  Phe Ala Asn Ser His  Tyr Ser Ser 
    2255                 2260                 2265             


Arg Leu  Gly Ser Ala Ile Phe  Ser Ser Gly Asp Asp  Leu Gly Glu 
    2270                 2275                 2280             


Asp Asp  Glu Asp Ala Pro Met  Ile Thr Gly Phe Ser  Asp Asp Val 
    2285                 2290                 2295             


Pro Met  Val Ile Ala 
    2300             


<210>  7
<211>  2306
<212>  PRT
<213>  Artificial

<220>
<223>  sorLA-reporter construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2306)
<223>  sorLA-reporter construct

<400>  7

Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala Ser 
1               5                   10                  15      


Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro Gly 
            20                  25                  30          


Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Ile Glu Ala Asn Ala Arg 
        35                  40                  45              


Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile Lys 
    50                  55                  60                  


Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr Tyr 
65                  70                  75                  80  


Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala Ile Val 
                85                  90                  95      


Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro Ile Glu Gln 
            100                 105                 110         


Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr Gly Cys Leu 
        115                 120                 125             


Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys Lys Trp Leu 
    130                 135                 140                 


Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln Val Asp 
145                 150                 155                 160 


Lys Ile Lys Gly Ala Gly Gly Asp Leu Ser Arg Ser Glu Ser Ala Ala 
                165                 170                 175     


Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val Ser Leu Asn Asp 
            180                 185                 190         


Ser His Asn Gln Met Val Val His Trp Ala Gly Glu Lys Ser Asn Val 
        195                 200                 205             


Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala Arg Pro Lys Ser 
    210                 215                 220                 


Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser Phe Lys Lys Ile 
225                 230                 235                 240 


Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser Glu Ala Val Ile 
                245                 250                 255     


Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg Tyr Ile Phe Ala 
            260                 265                 270         


Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp Phe Cys Asn Thr 
        275                 280                 285             


Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp Leu Leu Leu His 
    290                 295                 300                 


Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg Ser His Pro Asn 
305                 310                 315                 320 


Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr Trp Ile Met Ile 
                325                 330                 335     


Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp Pro Tyr Asp Lys 
            340                 345                 350         


Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser Gly Tyr Ser Thr 
        355                 360                 365             


Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu Asn Gln Glu Val 
    370                 375                 380                 


Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp Lys Tyr Met Phe 
385                 390                 395                 400 


Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln Gln Ser Ser Val 
                405                 410                 415     


Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg Ala Ala Gln Phe 
            420                 425                 430         


Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala Asp Ala Ser Glu 
        435                 440                 445             


Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn Arg Thr Asn Leu 
    450                 455                 460                 


Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu Ser Leu Glu Asn 
465                 470                 475                 480 


Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp Thr Leu Val Arg 
                485                 490                 495     


Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg Val Glu Gly Leu 
            500                 505                 510         


Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser Met Asn Glu Glu 
        515                 520                 525             


Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly Thr Trp Glu Phe 
    530                 535                 540                 


Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys Ile Asn Cys Glu 
545                 550                 555                 560 


Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg Leu Ser Gln Leu 
                565                 570                 575     


Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser Lys Glu Ser Ala 
            580                 585                 590         


Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys Asn Leu Ala Ser 
        595                 600                 605             


Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala Arg Trp Arg Glu 
    610                 615                 620                 


Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp His Gly Gly Ile 
625                 630                 635                 640 


Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu Leu Lys Tyr Ser 
                645                 650                 655     


Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe Ser Glu Lys Pro 
            660                 665                 670         


Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu Lys Ser Thr Val 
        675                 680                 685             


Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His Ser Trp Leu Ile 
    690                 695                 700                 


Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro Cys Thr Glu Asn 
705                 710                 715                 720 


Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly Asn Glu Cys Leu 
                725                 730                 735     


Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro His Ala Thr Cys 
            740                 745                 750         


Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val Ser Asn Cys Ser 
        755                 760                 765             


Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe Lys Met Ser Glu 
    770                 775                 780                 


Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu Phe Ser Gly Lys 
785                 790                 795                 800 


Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser Thr Tyr Arg Arg 
                805                 810                 815     


Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys Ser Gly Gly Asp 
            820                 825                 830         


Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys Pro Leu Ala Glu 
        835                 840                 845             


Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser Ile Tyr Arg Tyr 
    850                 855                 860                 


Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu Thr Gly Leu Arg 
865                 870                 875                 880 


Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn Cys Leu Tyr Trp 
                885                 890                 895     


Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys Leu Asn Gly Ser 
            900                 905                 910         


Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu Thr Val Glu Ala 
        915                 920                 925             


Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp Val Asp Ala Gly 
    930                 935                 940                 


Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp Phe Arg Leu Thr 
945                 950                 955                 960 


Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala Leu Val Leu Val 
                965                 970                 975     


Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly Asp Leu Lys Pro 
            980                 985                 990         


Gly Ile Tyr Arg Ser Asn Met Asp  Gly Ser Ala Ala Tyr  His Leu Val 
        995                 1000                 1005             


Ser Glu  Asp Val Lys Trp Pro  Asn Gly Ile Ser Val  Asp Asp Gln 
    1010                 1015                 1020             


Trp Ile  Tyr Trp Thr Asp Ala  Tyr Leu Glu Cys Ile  Glu Arg Ile 
    1025                 1030                 1035             


Thr Phe  Ser Gly Gln Gln Arg  Ser Val Ile Leu Asp  Asn Leu Pro 
    1040                 1045                 1050             


His Pro  Tyr Ala Ile Ala Val  Phe Lys Asn Glu Ile  Tyr Trp Asp 
    1055                 1060                 1065             


Asp Trp  Ser Gln Leu Ser Ile  Phe Arg Ala Ser Lys  Tyr Ser Gly 
    1070                 1075                 1080             


Ser Gln  Met Glu Ile Leu Ala  Asn Gln Leu Thr Gly  Leu Met Asp 
    1085                 1090                 1095             


Met Lys  Ile Phe Tyr Lys Gly  Lys Asn Thr Gly Ser  Asn Ala Cys 
    1100                 1105                 1110             


Val Pro  Arg Pro Cys Ser Leu  Leu Cys Leu Pro Lys  Ala Asn Asn 
    1115                 1120                 1125             


Ser Arg  Ser Cys Arg Cys Pro  Glu Asp Val Ser Ser  Ser Val Leu 
    1130                 1135                 1140             


Pro Ser  Gly Asp Leu Met Cys  Asp Cys Pro Gln Gly  Tyr Gln Leu 
    1145                 1150                 1155             


Lys Asn  Asn Thr Cys Val Lys  Gln Glu Asn Thr Cys  Leu Arg Asn 
    1160                 1165                 1170             


Gln Tyr  Arg Cys Ser Asn Gly  Asn Cys Ile Asn Ser  Ile Trp Trp 
    1175                 1180                 1185             


Cys Asp  Phe Asp Asn Asp Cys  Gly Asp Met Ser Asp  Glu Arg Asn 
    1190                 1195                 1200             


Cys Pro  Thr Thr Ile Cys Asp  Leu Asp Thr Gln Phe  Arg Cys Gln 
    1205                 1210                 1215             


Glu Ser  Gly Thr Cys Ile Pro  Leu Ser Tyr Lys Cys  Asp Leu Glu 
    1220                 1225                 1230             


Asp Asp  Cys Gly Asp Asn Ser  Asp Glu Ser His Cys  Glu Met His 
    1235                 1240                 1245             


Gln Cys  Arg Ser Asp Glu Tyr  Asn Cys Ser Ser Gly  Met Cys Ile 
    1250                 1255                 1260             


Arg Ser  Ser Trp Val Cys Asp  Gly Asp Asn Asp Cys  Arg Asp Trp 
    1265                 1270                 1275             


Ser Asp  Glu Ala Asn Cys Thr  Ala Ile Tyr His Thr  Cys Glu Ala 
    1280                 1285                 1290             


Ser Asn  Phe Gln Cys Arg Asn  Gly His Cys Ile Pro  Gln Arg Trp 
    1295                 1300                 1305             


Ala Cys  Asp Gly Asp Thr Asp  Cys Gln Asp Gly Ser  Asp Glu Asp 
    1310                 1315                 1320             


Pro Val  Asn Cys Glu Lys Lys  Cys Asn Gly Phe Arg  Cys Pro Asn 
    1325                 1330                 1335             


Gly Thr  Cys Ile Pro Ser Ser  Lys His Cys Asp Gly  Leu Arg Asp 
    1340                 1345                 1350             


Cys Ser  Asp Gly Ser Asp Glu  Gln His Cys Glu Pro  Leu Cys Thr 
    1355                 1360                 1365             


His Phe  Met Asp Phe Val Cys  Lys Asn Arg Gln Gln  Cys Leu Phe 
    1370                 1375                 1380             


His Ser  Met Val Cys Asp Gly  Ile Ile Gln Cys Arg  Asp Gly Ser 
    1385                 1390                 1395             


Asp Glu  Asp Ala Ala Phe Ala  Gly Cys Ser Gln Asp  Pro Glu Phe 
    1400                 1405                 1410             


His Lys  Val Cys Asp Glu Phe  Gly Phe Gln Cys Gln  Asn Gly Val 
    1415                 1420                 1425             


Cys Ile  Ser Leu Ile Trp Lys  Cys Asp Gly Met Asp  Asp Cys Gly 
    1430                 1435                 1440             


Asp Tyr  Ser Asp Glu Ala Asn  Cys Glu Asn Pro Thr  Glu Ala Pro 
    1445                 1450                 1455             


Asn Cys  Ser Arg Tyr Phe Gln  Phe Arg Cys Glu Asn  Gly His Cys 
    1460                 1465                 1470             


Ile Pro  Asn Arg Trp Lys Cys  Asp Arg Glu Asn Asp  Cys Gly Asp 
    1475                 1480                 1485             


Trp Ser  Asp Glu Lys Asp Cys  Gly Asp Ser His Ile  Leu Pro Phe 
    1490                 1495                 1500             


Ser Thr  Pro Gly Pro Ser Thr  Cys Leu Pro Asn Tyr  Tyr Arg Cys 
    1505                 1510                 1515             


Ser Ser  Gly Thr Cys Val Met  Asp Thr Trp Val Cys  Asp Gly Tyr 
    1520                 1525                 1530             


Arg Asp  Cys Ala Asp Gly Ser  Asp Glu Glu Ala Cys  Pro Leu Leu 
    1535                 1540                 1545             


Ala Asn  Val Thr Ala Ala Ser  Thr Pro Thr Gln Leu  Gly Arg Cys 
    1550                 1555                 1560             


Asp Arg  Phe Glu Phe Glu Cys  His Gln Pro Lys Thr  Cys Ile Pro 
    1565                 1570                 1575             


Asn Trp  Lys Arg Cys Asp Gly  His Gln Asp Cys Gln  Asp Gly Arg 
    1580                 1585                 1590             


Asp Glu  Ala Asn Cys Pro Thr  His Ser Thr Leu Thr  Cys Met Ser 
    1595                 1600                 1605             


Arg Glu  Phe Gln Cys Glu Asp  Gly Glu Ala Cys Ile  Val Leu Ser 
    1610                 1615                 1620             


Glu Arg  Cys Asp Gly Phe Leu  Asp Cys Ser Asp Glu  Ser Asp Glu 
    1625                 1630                 1635             


Lys Ala  Cys Ser Asp Glu Leu  Thr Val Tyr Lys Val  Gln Asn Leu 
    1640                 1645                 1650             


Gln Trp  Thr Ala Asp Phe Ser  Gly Asp Val Thr Leu  Thr Trp Met 
    1655                 1660                 1665             


Arg Pro  Lys Lys Met Pro Ser  Ala Ser Cys Val Tyr  Asn Val Tyr 
    1670                 1675                 1680             


Tyr Arg  Val Val Gly Glu Ser  Ile Trp Lys Thr Leu  Glu Thr His 
    1685                 1690                 1695             


Ser Asn  Lys Thr Asn Thr Val  Leu Lys Val Leu Lys  Pro Asp Thr 
    1700                 1705                 1710             


Thr Tyr  Gln Val Lys Val Gln  Val Gln Cys Leu Ser  Lys Ala His 
    1715                 1720                 1725             


Asn Thr  Asn Asp Phe Val Thr  Leu Arg Thr Pro Glu  Gly Leu Pro 
    1730                 1735                 1740             


Asp Ala  Pro Arg Asn Leu Gln  Leu Ser Leu Pro Arg  Glu Ala Glu 
    1745                 1750                 1755             


Gly Val  Ile Val Gly His Trp  Ala Pro Pro Ile His  Thr His Gly 
    1760                 1765                 1770             


Leu Ile  Arg Glu Tyr Ile Val  Glu Tyr Ser Arg Ser  Gly Ser Lys 
    1775                 1780                 1785             


Met Trp  Ala Ser Gln Arg Ala  Ala Ser Asn Phe Thr  Glu Ile Lys 
    1790                 1795                 1800             


Asn Leu  Leu Val Asn Thr Leu  Tyr Thr Val Arg Val  Ala Ala Val 
    1805                 1810                 1815             


Thr Ser  Arg Gly Ile Gly Asn  Trp Ser Asp Ser Lys  Ser Ile Thr 
    1820                 1825                 1830             


Thr Ile  Lys Gly Lys Val Ile  Pro Pro Pro Asp Ile  His Ile Asp 
    1835                 1840                 1845             


Ser Tyr  Gly Glu Asn Tyr Leu  Ser Phe Thr Leu Thr  Met Glu Ser 
    1850                 1855                 1860             


Asp Ile  Lys Val Asn Gly Tyr  Val Val Asn Leu Phe  Trp Ala Phe 
    1865                 1870                 1875             


Asp Thr  His Lys Gln Glu Arg  Arg Thr Leu Asn Phe  Arg Gly Ser 
    1880                 1885                 1890             


Ile Leu  Ser His Lys Val Gly  Asn Leu Thr Ala His  Thr Ser Tyr 
    1895                 1900                 1905             


Glu Ile  Ser Ala Trp Ala Lys  Thr Asp Leu Gly Asp  Ser Pro Leu 
    1910                 1915                 1920             


Ala Phe  Glu His Val Met Thr  Arg Gly Val Arg Pro  Pro Ala Pro 
    1925                 1930                 1935             


Ser Leu  Lys Ala Lys Ala Ile  Asn Gln Thr Ala Val  Glu Cys Thr 
    1940                 1945                 1950             


Trp Thr  Gly Pro Arg Asn Val  Val Tyr Gly Ile Phe  Tyr Ala Thr 
    1955                 1960                 1965             


Ser Phe  Leu Asp Leu Tyr Arg  Asn Pro Lys Ser Leu  Thr Thr Ser 
    1970                 1975                 1980             


Leu His  Asn Lys Thr Val Ile  Val Ser Lys Asp Glu  Gln Tyr Leu 
    1985                 1990                 1995             


Phe Leu  Val Arg Val Val Val  Pro Tyr Gln Gly Pro  Ser Ser Asp 
    2000                 2005                 2010             


Tyr Val  Val Val Lys Met Ile  Pro Asp Ser Arg Leu  Pro Pro Arg 
    2015                 2020                 2025             


His Leu  His Val Val His Thr  Gly Lys Thr Ser Val  Val Ile Lys 
    2030                 2035                 2040             


Trp Glu  Ser Pro Tyr Asp Ser  Pro Asp Gln Asp Leu  Leu Tyr Ala 
    2045                 2050                 2055             


Val Ala  Val Lys Asp Leu Ile  Arg Lys Thr Asp Arg  Ser Tyr Lys 
    2060                 2065                 2070             


Val Lys  Ser Arg Asn Ser Thr  Val Glu Tyr Thr Leu  Asn Lys Leu 
    2075                 2080                 2085             


Glu Pro  Gly Gly Lys Tyr His  Ile Ile Val Gln Leu  Gly Asn Met 
    2090                 2095                 2100             


Ser Lys  Asp Ser Ser Ile Lys  Ile Thr Thr Val Ser  Leu Ser Ala 
    2105                 2110                 2115             


Pro Asp  Ala Leu Lys Ile Ile  Thr Glu Asn Asp His  Val Leu Leu 
    2120                 2125                 2130             


Phe Trp  Lys Ser Leu Ala Leu  Lys Glu Lys His Phe  Asn Glu Ser 
    2135                 2140                 2145             


Arg Gly  Tyr Glu Ile His Met  Phe Asp Ser Ala Met  Asn Ile Thr 
    2150                 2155                 2160             


Ala Tyr  Leu Gly Asn Thr Thr  Asp Asn Phe Phe Lys  Ile Ser Asn 
    2165                 2170                 2175             


Leu Lys  Met Gly His Asn Tyr  Thr Phe Thr Val Gln  Ala Arg Cys 
    2180                 2185                 2190             


Leu Phe  Gly Asn Gln Ile Cys  Gly Glu Pro Ala Ile  Leu Leu Tyr 
    2195                 2200                 2205             


Asp Glu  Leu Gly Ser Gly Ala  Asp Ala Ser Ala Thr  Gln Ala Ala 
    2210                 2215                 2220             


Arg Ser  Thr Asp Val Ala Ala  Val Val Val Pro Ile  Leu Phe Leu 
    2225                 2230                 2235             


Ile Leu  Leu Ser Leu Gly Val  Gly Phe Ala Ile Leu  Tyr Thr Lys 
    2240                 2245                 2250             


His Arg  Arg Leu Gln Ser Ser  Phe Thr Ala Phe Ala  Asn Ser His 
    2255                 2260                 2265             


Tyr Ser  Ser Arg Leu Gly Ser  Ala Ile Phe Ser Ser  Gly Asp Asp 
    2270                 2275                 2280             


Leu Gly  Glu Asp Asp Glu Asp  Ala Pro Met Ile Thr  Gly Phe Ser 
    2285                 2290                 2295             


Asp Asp  Val Pro Met Val Ile  Ala 
    2300                 2305     


<210>  8
<211>  2309
<212>  PRT
<213>  Artificial

<220>
<223>  sorLA-reporter construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2309)
<223>  sorLA-reporter construct

<400>  8

Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala Ser 
1               5                   10                  15      


Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro Gly 
            20                  25                  30          


Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Ile Glu Ala Asn Ala Arg 
        35                  40                  45              


Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile Lys 
    50                  55                  60                  


Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr Tyr 
65                  70                  75                  80  


Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala Ile Val 
                85                  90                  95      


Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro Ile Glu Gln 
            100                 105                 110         


Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr Gly Cys Leu 
        115                 120                 125             


Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys Lys Trp Leu 
    130                 135                 140                 


Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln Val Asp 
145                 150                 155                 160 


Lys Ile Lys Gly Ala Gly Gly Asp Leu Ser Arg Ser Ser Gly Gly Glu 
                165                 170                 175     


Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val Ser 
            180                 185                 190         


Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu Lys 
        195                 200                 205             


Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala Arg 
    210                 215                 220                 


Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser Phe 
225                 230                 235                 240 


Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser Glu 
                245                 250                 255     


Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg Tyr 
            260                 265                 270         


Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp Phe 
        275                 280                 285             


Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp Leu 
    290                 295                 300                 


Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg Ser 
305                 310                 315                 320 


His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr Trp 
                325                 330                 335     


Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp Pro 
            340                 345                 350         


Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser Gly 
        355                 360                 365             


Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu Asn 
    370                 375                 380                 


Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp Lys 
385                 390                 395                 400 


Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln Gln 
                405                 410                 415     


Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg Ala 
            420                 425                 430         


Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala Asp 
        435                 440                 445             


Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn Arg 
    450                 455                 460                 


Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu Ser 
465                 470                 475                 480 


Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp Thr 
                485                 490                 495     


Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg Val 
            500                 505                 510         


Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser Met 
        515                 520                 525             


Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly Thr 
    530                 535                 540                 


Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys Ile 
545                 550                 555                 560 


Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg Leu 
                565                 570                 575     


Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser Lys 
            580                 585                 590         


Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys Asn 
        595                 600                 605             


Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala Arg 
    610                 615                 620                 


Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp His 
625                 630                 635                 640 


Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu Leu 
                645                 650                 655     


Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe Ser 
            660                 665                 670         


Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu Lys 
        675                 680                 685             


Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His Ser 
    690                 695                 700                 


Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro Cys 
705                 710                 715                 720 


Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly Asn 
                725                 730                 735     


Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro His 
            740                 745                 750         


Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val Ser 
        755                 760                 765             


Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe Lys 
    770                 775                 780                 


Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu Phe 
785                 790                 795                 800 


Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser Thr 
                805                 810                 815     


Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys Ser 
            820                 825                 830         


Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys Pro 
        835                 840                 845             


Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser Ile 
    850                 855                 860                 


Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu Thr 
865                 870                 875                 880 


Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn Cys 
                885                 890                 895     


Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys Leu 
            900                 905                 910         


Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu Thr 
        915                 920                 925             


Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp Val 
    930                 935                 940                 


Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp Phe 
945                 950                 955                 960 


Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala Leu 
                965                 970                 975     


Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly Asp 
            980                 985                 990         


Leu Lys Pro Gly Ile Tyr Arg Ser  Asn Met Asp Gly Ser  Ala Ala Tyr 
        995                 1000                 1005             


His Leu  Val Ser Glu Asp Val  Lys Trp Pro Asn Gly  Ile Ser Val 
    1010                 1015                 1020             


Asp Asp  Gln Trp Ile Tyr Trp  Thr Asp Ala Tyr Leu  Glu Cys Ile 
    1025                 1030                 1035             


Glu Arg  Ile Thr Phe Ser Gly  Gln Gln Arg Ser Val  Ile Leu Asp 
    1040                 1045                 1050             


Asn Leu  Pro His Pro Tyr Ala  Ile Ala Val Phe Lys  Asn Glu Ile 
    1055                 1060                 1065             


Tyr Trp  Asp Asp Trp Ser Gln  Leu Ser Ile Phe Arg  Ala Ser Lys 
    1070                 1075                 1080             


Tyr Ser  Gly Ser Gln Met Glu  Ile Leu Ala Asn Gln  Leu Thr Gly 
    1085                 1090                 1095             


Leu Met  Asp Met Lys Ile Phe  Tyr Lys Gly Lys Asn  Thr Gly Ser 
    1100                 1105                 1110             


Asn Ala  Cys Val Pro Arg Pro  Cys Ser Leu Leu Cys  Leu Pro Lys 
    1115                 1120                 1125             


Ala Asn  Asn Ser Arg Ser Cys  Arg Cys Pro Glu Asp  Val Ser Ser 
    1130                 1135                 1140             


Ser Val  Leu Pro Ser Gly Asp  Leu Met Cys Asp Cys  Pro Gln Gly 
    1145                 1150                 1155             


Tyr Gln  Leu Lys Asn Asn Thr  Cys Val Lys Gln Glu  Asn Thr Cys 
    1160                 1165                 1170             


Leu Arg  Asn Gln Tyr Arg Cys  Ser Asn Gly Asn Cys  Ile Asn Ser 
    1175                 1180                 1185             


Ile Trp  Trp Cys Asp Phe Asp  Asn Asp Cys Gly Asp  Met Ser Asp 
    1190                 1195                 1200             


Glu Arg  Asn Cys Pro Thr Thr  Ile Cys Asp Leu Asp  Thr Gln Phe 
    1205                 1210                 1215             


Arg Cys  Gln Glu Ser Gly Thr  Cys Ile Pro Leu Ser  Tyr Lys Cys 
    1220                 1225                 1230             


Asp Leu  Glu Asp Asp Cys Gly  Asp Asn Ser Asp Glu  Ser His Cys 
    1235                 1240                 1245             


Glu Met  His Gln Cys Arg Ser  Asp Glu Tyr Asn Cys  Ser Ser Gly 
    1250                 1255                 1260             


Met Cys  Ile Arg Ser Ser Trp  Val Cys Asp Gly Asp  Asn Asp Cys 
    1265                 1270                 1275             


Arg Asp  Trp Ser Asp Glu Ala  Asn Cys Thr Ala Ile  Tyr His Thr 
    1280                 1285                 1290             


Cys Glu  Ala Ser Asn Phe Gln  Cys Arg Asn Gly His  Cys Ile Pro 
    1295                 1300                 1305             


Gln Arg  Trp Ala Cys Asp Gly  Asp Thr Asp Cys Gln  Asp Gly Ser 
    1310                 1315                 1320             


Asp Glu  Asp Pro Val Asn Cys  Glu Lys Lys Cys Asn  Gly Phe Arg 
    1325                 1330                 1335             


Cys Pro  Asn Gly Thr Cys Ile  Pro Ser Ser Lys His  Cys Asp Gly 
    1340                 1345                 1350             


Leu Arg  Asp Cys Ser Asp Gly  Ser Asp Glu Gln His  Cys Glu Pro 
    1355                 1360                 1365             


Leu Cys  Thr His Phe Met Asp  Phe Val Cys Lys Asn  Arg Gln Gln 
    1370                 1375                 1380             


Cys Leu  Phe His Ser Met Val  Cys Asp Gly Ile Ile  Gln Cys Arg 
    1385                 1390                 1395             


Asp Gly  Ser Asp Glu Asp Ala  Ala Phe Ala Gly Cys  Ser Gln Asp 
    1400                 1405                 1410             


Pro Glu  Phe His Lys Val Cys  Asp Glu Phe Gly Phe  Gln Cys Gln 
    1415                 1420                 1425             


Asn Gly  Val Cys Ile Ser Leu  Ile Trp Lys Cys Asp  Gly Met Asp 
    1430                 1435                 1440             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Ala Asn Cys Glu  Asn Pro Thr 
    1445                 1450                 1455             


Glu Ala  Pro Asn Cys Ser Arg  Tyr Phe Gln Phe Arg  Cys Glu Asn 
    1460                 1465                 1470             


Gly His  Cys Ile Pro Asn Arg  Trp Lys Cys Asp Arg  Glu Asn Asp 
    1475                 1480                 1485             


Cys Gly  Asp Trp Ser Asp Glu  Lys Asp Cys Gly Asp  Ser His Ile 
    1490                 1495                 1500             


Leu Pro  Phe Ser Thr Pro Gly  Pro Ser Thr Cys Leu  Pro Asn Tyr 
    1505                 1510                 1515             


Tyr Arg  Cys Ser Ser Gly Thr  Cys Val Met Asp Thr  Trp Val Cys 
    1520                 1525                 1530             


Asp Gly  Tyr Arg Asp Cys Ala  Asp Gly Ser Asp Glu  Glu Ala Cys 
    1535                 1540                 1545             


Pro Leu  Leu Ala Asn Val Thr  Ala Ala Ser Thr Pro  Thr Gln Leu 
    1550                 1555                 1560             


Gly Arg  Cys Asp Arg Phe Glu  Phe Glu Cys His Gln  Pro Lys Thr 
    1565                 1570                 1575             


Cys Ile  Pro Asn Trp Lys Arg  Cys Asp Gly His Gln  Asp Cys Gln 
    1580                 1585                 1590             


Asp Gly  Arg Asp Glu Ala Asn  Cys Pro Thr His Ser  Thr Leu Thr 
    1595                 1600                 1605             


Cys Met  Ser Arg Glu Phe Gln  Cys Glu Asp Gly Glu  Ala Cys Ile 
    1610                 1615                 1620             


Val Leu  Ser Glu Arg Cys Asp  Gly Phe Leu Asp Cys  Ser Asp Glu 
    1625                 1630                 1635             


Ser Asp  Glu Lys Ala Cys Ser  Asp Glu Leu Thr Val  Tyr Lys Val 
    1640                 1645                 1650             


Gln Asn  Leu Gln Trp Thr Ala  Asp Phe Ser Gly Asp  Val Thr Leu 
    1655                 1660                 1665             


Thr Trp  Met Arg Pro Lys Lys  Met Pro Ser Ala Ser  Cys Val Tyr 
    1670                 1675                 1680             


Asn Val  Tyr Tyr Arg Val Val  Gly Glu Ser Ile Trp  Lys Thr Leu 
    1685                 1690                 1695             


Glu Thr  His Ser Asn Lys Thr  Asn Thr Val Leu Lys  Val Leu Lys 
    1700                 1705                 1710             


Pro Asp  Thr Thr Tyr Gln Val  Lys Val Gln Val Gln  Cys Leu Ser 
    1715                 1720                 1725             


Lys Ala  His Asn Thr Asn Asp  Phe Val Thr Leu Arg  Thr Pro Glu 
    1730                 1735                 1740             


Gly Leu  Pro Asp Ala Pro Arg  Asn Leu Gln Leu Ser  Leu Pro Arg 
    1745                 1750                 1755             


Glu Ala  Glu Gly Val Ile Val  Gly His Trp Ala Pro  Pro Ile His 
    1760                 1765                 1770             


Thr His  Gly Leu Ile Arg Glu  Tyr Ile Val Glu Tyr  Ser Arg Ser 
    1775                 1780                 1785             


Gly Ser  Lys Met Trp Ala Ser  Gln Arg Ala Ala Ser  Asn Phe Thr 
    1790                 1795                 1800             


Glu Ile  Lys Asn Leu Leu Val  Asn Thr Leu Tyr Thr  Val Arg Val 
    1805                 1810                 1815             


Ala Ala  Val Thr Ser Arg Gly  Ile Gly Asn Trp Ser  Asp Ser Lys 
    1820                 1825                 1830             


Ser Ile  Thr Thr Ile Lys Gly  Lys Val Ile Pro Pro  Pro Asp Ile 
    1835                 1840                 1845             


His Ile  Asp Ser Tyr Gly Glu  Asn Tyr Leu Ser Phe  Thr Leu Thr 
    1850                 1855                 1860             


Met Glu  Ser Asp Ile Lys Val  Asn Gly Tyr Val Val  Asn Leu Phe 
    1865                 1870                 1875             


Trp Ala  Phe Asp Thr His Lys  Gln Glu Arg Arg Thr  Leu Asn Phe 
    1880                 1885                 1890             


Arg Gly  Ser Ile Leu Ser His  Lys Val Gly Asn Leu  Thr Ala His 
    1895                 1900                 1905             


Thr Ser  Tyr Glu Ile Ser Ala  Trp Ala Lys Thr Asp  Leu Gly Asp 
    1910                 1915                 1920             


Ser Pro  Leu Ala Phe Glu His  Val Met Thr Arg Gly  Val Arg Pro 
    1925                 1930                 1935             


Pro Ala  Pro Ser Leu Lys Ala  Lys Ala Ile Asn Gln  Thr Ala Val 
    1940                 1945                 1950             


Glu Cys  Thr Trp Thr Gly Pro  Arg Asn Val Val Tyr  Gly Ile Phe 
    1955                 1960                 1965             


Tyr Ala  Thr Ser Phe Leu Asp  Leu Tyr Arg Asn Pro  Lys Ser Leu 
    1970                 1975                 1980             


Thr Thr  Ser Leu His Asn Lys  Thr Val Ile Val Ser  Lys Asp Glu 
    1985                 1990                 1995             


Gln Tyr  Leu Phe Leu Val Arg  Val Val Val Pro Tyr  Gln Gly Pro 
    2000                 2005                 2010             


Ser Ser  Asp Tyr Val Val Val  Lys Met Ile Pro Asp  Ser Arg Leu 
    2015                 2020                 2025             


Pro Pro  Arg His Leu His Val  Val His Thr Gly Lys  Thr Ser Val 
    2030                 2035                 2040             


Val Ile  Lys Trp Glu Ser Pro  Tyr Asp Ser Pro Asp  Gln Asp Leu 
    2045                 2050                 2055             


Leu Tyr  Ala Val Ala Val Lys  Asp Leu Ile Arg Lys  Thr Asp Arg 
    2060                 2065                 2070             


Ser Tyr  Lys Val Lys Ser Arg  Asn Ser Thr Val Glu  Tyr Thr Leu 
    2075                 2080                 2085             


Asn Lys  Leu Glu Pro Gly Gly  Lys Tyr His Ile Ile  Val Gln Leu 
    2090                 2095                 2100             


Gly Asn  Met Ser Lys Asp Ser  Ser Ile Lys Ile Thr  Thr Val Ser 
    2105                 2110                 2115             


Leu Ser  Ala Pro Asp Ala Leu  Lys Ile Ile Thr Glu  Asn Asp His 
    2120                 2125                 2130             


Val Leu  Leu Phe Trp Lys Ser  Leu Ala Leu Lys Glu  Lys His Phe 
    2135                 2140                 2145             


Asn Glu  Ser Arg Gly Tyr Glu  Ile His Met Phe Asp  Ser Ala Met 
    2150                 2155                 2160             


Asn Ile  Thr Ala Tyr Leu Gly  Asn Thr Thr Asp Asn  Phe Phe Lys 
    2165                 2170                 2175             


Ile Ser  Asn Leu Lys Met Gly  His Asn Tyr Thr Phe  Thr Val Gln 
    2180                 2185                 2190             


Ala Arg  Cys Leu Phe Gly Asn  Gln Ile Cys Gly Glu  Pro Ala Ile 
    2195                 2200                 2205             


Leu Leu  Tyr Asp Glu Leu Gly  Ser Gly Ala Asp Ala  Ser Ala Thr 
    2210                 2215                 2220             


Gln Ala  Ala Arg Ser Thr Asp  Val Ala Ala Val Val  Val Pro Ile 
    2225                 2230                 2235             


Leu Phe  Leu Ile Leu Leu Ser  Leu Gly Val Gly Phe  Ala Ile Leu 
    2240                 2245                 2250             


Tyr Thr  Lys His Arg Arg Leu  Gln Ser Ser Phe Thr  Ala Phe Ala 
    2255                 2260                 2265             


Asn Ser  His Tyr Ser Ser Arg  Leu Gly Ser Ala Ile  Phe Ser Ser 
    2270                 2275                 2280             


Gly Asp  Asp Leu Gly Glu Asp  Asp Glu Asp Ala Pro  Met Ile Thr 
    2285                 2290                 2295             


Gly Phe  Ser Asp Asp Val Pro  Met Val Ile Ala 
    2300                 2305                 


<210>  9
<211>  2354
<212>  PRT
<213>  Artificial

<220>
<223>  sorLA-reporter construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2354)
<223>  sorLA-reporter construct

<400>  9

Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala Ser 
1               5                   10                  15      


Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro Gly 
            20                  25                  30          


Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Ile Glu Ala Asn Ala Arg 
        35                  40                  45              


Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile Lys 
    50                  55                  60                  


Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr Tyr 
65                  70                  75                  80  


Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala Ile Val 
                85                  90                  95      


Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro Ile Glu Gln 
            100                 105                 110         


Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr Gly Cys Leu 
        115                 120                 125             


Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys Lys Trp Leu 
    130                 135                 140                 


Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln Val Asp 
145                 150                 155                 160 


Lys Ile Lys Gly Ala Gly Gly Asp Glu Val Trp Thr Gln Arg Leu His 
                165                 170                 175     


Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe Leu Val Val Gln 
            180                 185                 190         


Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly Asp Ala Arg Gly 
        195                 200                 205             


Ala Ser Arg Ala Asp Glu Lys Pro Leu Gly Ser Gly Ser Ser Ala Ala 
    210                 215                 220                 


Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val Ser Leu Asn Asp 
225                 230                 235                 240 


Ser His Asn Gln Met Val Val His Trp Ala Gly Glu Lys Ser Asn Val 
                245                 250                 255     


Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala Arg Pro Lys Ser 
            260                 265                 270         


Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser Phe Lys Lys Ile 
        275                 280                 285             


Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser Glu Ala Val Ile 
    290                 295                 300                 


Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg Tyr Ile Phe Ala 
305                 310                 315                 320 


Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp Phe Cys Asn Thr 
                325                 330                 335     


Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp Leu Leu Leu His 
            340                 345                 350         


Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg Ser His Pro Asn 
        355                 360                 365             


Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr Trp Ile Met Ile 
    370                 375                 380                 


Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp Pro Tyr Asp Lys 
385                 390                 395                 400 


Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser Gly Tyr Ser Thr 
                405                 410                 415     


Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu Asn Gln Glu Val 
            420                 425                 430         


Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp Lys Tyr Met Phe 
        435                 440                 445             


Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln Gln Ser Ser Val 
    450                 455                 460                 


Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg Ala Ala Gln Phe 
465                 470                 475                 480 


Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala Asp Ala Ser Glu 
                485                 490                 495     


Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn Arg Thr Asn Leu 
            500                 505                 510         


Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu Ser Leu Glu Asn 
        515                 520                 525             


Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp Thr Leu Val Arg 
    530                 535                 540                 


Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg Val Glu Gly Leu 
545                 550                 555                 560 


Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser Met Asn Glu Glu 
                565                 570                 575     


Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly Thr Trp Glu Phe 
            580                 585                 590         


Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys Ile Asn Cys Glu 
        595                 600                 605             


Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg Leu Ser Gln Leu 
    610                 615                 620                 


Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser Lys Glu Ser Ala 
625                 630                 635                 640 


Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys Asn Leu Ala Ser 
                645                 650                 655     


Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala Arg Trp Arg Glu 
            660                 665                 670         


Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp His Gly Gly Ile 
        675                 680                 685             


Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu Leu Lys Tyr Ser 
    690                 695                 700                 


Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe Ser Glu Lys Pro 
705                 710                 715                 720 


Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu Lys Ser Thr Val 
                725                 730                 735     


Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His Ser Trp Leu Ile 
            740                 745                 750         


Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro Cys Thr Glu Asn 
        755                 760                 765             


Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly Asn Glu Cys Leu 
    770                 775                 780                 


Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro His Ala Thr Cys 
785                 790                 795                 800 


Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val Ser Asn Cys Ser 
                805                 810                 815     


Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe Lys Met Ser Glu 
            820                 825                 830         


Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu Phe Ser Gly Lys 
        835                 840                 845             


Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser Thr Tyr Arg Arg 
    850                 855                 860                 


Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys Ser Gly Gly Asp 
865                 870                 875                 880 


Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys Pro Leu Ala Glu 
                885                 890                 895     


Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser Ile Tyr Arg Tyr 
            900                 905                 910         


Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu Thr Gly Leu Arg 
        915                 920                 925             


Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn Cys Leu Tyr Trp 
    930                 935                 940                 


Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys Leu Asn Gly Ser 
945                 950                 955                 960 


Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu Thr Val Glu Ala 
                965                 970                 975     


Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp Val Asp Ala Gly 
            980                 985                 990         


Phe Lys Lys Ile Glu Val Ala Asn  Pro Asp Gly Asp Phe  Arg Leu Thr 
        995                 1000                 1005             


Ile Val  Asn Ser Ser Val Leu  Asp Arg Pro Arg Ala  Leu Val Leu 
    1010                 1015                 1020             


Val Pro  Gln Glu Gly Val Met  Phe Trp Thr Asp Trp  Gly Asp Leu 
    1025                 1030                 1035             


Lys Pro  Gly Ile Tyr Arg Ser  Asn Met Asp Gly Ser  Ala Ala Tyr 
    1040                 1045                 1050             


His Leu  Val Ser Glu Asp Val  Lys Trp Pro Asn Gly  Ile Ser Val 
    1055                 1060                 1065             


Asp Asp  Gln Trp Ile Tyr Trp  Thr Asp Ala Tyr Leu  Glu Cys Ile 
    1070                 1075                 1080             


Glu Arg  Ile Thr Phe Ser Gly  Gln Gln Arg Ser Val  Ile Leu Asp 
    1085                 1090                 1095             


Asn Leu  Pro His Pro Tyr Ala  Ile Ala Val Phe Lys  Asn Glu Ile 
    1100                 1105                 1110             


Tyr Trp  Asp Asp Trp Ser Gln  Leu Ser Ile Phe Arg  Ala Ser Lys 
    1115                 1120                 1125             


Tyr Ser  Gly Ser Gln Met Glu  Ile Leu Ala Asn Gln  Leu Thr Gly 
    1130                 1135                 1140             


Leu Met  Asp Met Lys Ile Phe  Tyr Lys Gly Lys Asn  Thr Gly Ser 
    1145                 1150                 1155             


Asn Ala  Cys Val Pro Arg Pro  Cys Ser Leu Leu Cys  Leu Pro Lys 
    1160                 1165                 1170             


Ala Asn  Asn Ser Arg Ser Cys  Arg Cys Pro Glu Asp  Val Ser Ser 
    1175                 1180                 1185             


Ser Val  Leu Pro Ser Gly Asp  Leu Met Cys Asp Cys  Pro Gln Gly 
    1190                 1195                 1200             


Tyr Gln  Leu Lys Asn Asn Thr  Cys Val Lys Gln Glu  Asn Thr Cys 
    1205                 1210                 1215             


Leu Arg  Asn Gln Tyr Arg Cys  Ser Asn Gly Asn Cys  Ile Asn Ser 
    1220                 1225                 1230             


Ile Trp  Trp Cys Asp Phe Asp  Asn Asp Cys Gly Asp  Met Ser Asp 
    1235                 1240                 1245             


Glu Arg  Asn Cys Pro Thr Thr  Ile Cys Asp Leu Asp  Thr Gln Phe 
    1250                 1255                 1260             


Arg Cys  Gln Glu Ser Gly Thr  Cys Ile Pro Leu Ser  Tyr Lys Cys 
    1265                 1270                 1275             


Asp Leu  Glu Asp Asp Cys Gly  Asp Asn Ser Asp Glu  Ser His Cys 
    1280                 1285                 1290             


Glu Met  His Gln Cys Arg Ser  Asp Glu Tyr Asn Cys  Ser Ser Gly 
    1295                 1300                 1305             


Met Cys  Ile Arg Ser Ser Trp  Val Cys Asp Gly Asp  Asn Asp Cys 
    1310                 1315                 1320             


Arg Asp  Trp Ser Asp Glu Ala  Asn Cys Thr Ala Ile  Tyr His Thr 
    1325                 1330                 1335             


Cys Glu  Ala Ser Asn Phe Gln  Cys Arg Asn Gly His  Cys Ile Pro 
    1340                 1345                 1350             


Gln Arg  Trp Ala Cys Asp Gly  Asp Thr Asp Cys Gln  Asp Gly Ser 
    1355                 1360                 1365             


Asp Glu  Asp Pro Val Asn Cys  Glu Lys Lys Cys Asn  Gly Phe Arg 
    1370                 1375                 1380             


Cys Pro  Asn Gly Thr Cys Ile  Pro Ser Ser Lys His  Cys Asp Gly 
    1385                 1390                 1395             


Leu Arg  Asp Cys Ser Asp Gly  Ser Asp Glu Gln His  Cys Glu Pro 
    1400                 1405                 1410             


Leu Cys  Thr His Phe Met Asp  Phe Val Cys Lys Asn  Arg Gln Gln 
    1415                 1420                 1425             


Cys Leu  Phe His Ser Met Val  Cys Asp Gly Ile Ile  Gln Cys Arg 
    1430                 1435                 1440             


Asp Gly  Ser Asp Glu Asp Ala  Ala Phe Ala Gly Cys  Ser Gln Asp 
    1445                 1450                 1455             


Pro Glu  Phe His Lys Val Cys  Asp Glu Phe Gly Phe  Gln Cys Gln 
    1460                 1465                 1470             


Asn Gly  Val Cys Ile Ser Leu  Ile Trp Lys Cys Asp  Gly Met Asp 
    1475                 1480                 1485             


Asp Cys  Gly Asp Tyr Ser Asp  Glu Ala Asn Cys Glu  Asn Pro Thr 
    1490                 1495                 1500             


Glu Ala  Pro Asn Cys Ser Arg  Tyr Phe Gln Phe Arg  Cys Glu Asn 
    1505                 1510                 1515             


Gly His  Cys Ile Pro Asn Arg  Trp Lys Cys Asp Arg  Glu Asn Asp 
    1520                 1525                 1530             


Cys Gly  Asp Trp Ser Asp Glu  Lys Asp Cys Gly Asp  Ser His Ile 
    1535                 1540                 1545             


Leu Pro  Phe Ser Thr Pro Gly  Pro Ser Thr Cys Leu  Pro Asn Tyr 
    1550                 1555                 1560             


Tyr Arg  Cys Ser Ser Gly Thr  Cys Val Met Asp Thr  Trp Val Cys 
    1565                 1570                 1575             


Asp Gly  Tyr Arg Asp Cys Ala  Asp Gly Ser Asp Glu  Glu Ala Cys 
    1580                 1585                 1590             


Pro Leu  Leu Ala Asn Val Thr  Ala Ala Ser Thr Pro  Thr Gln Leu 
    1595                 1600                 1605             


Gly Arg  Cys Asp Arg Phe Glu  Phe Glu Cys His Gln  Pro Lys Thr 
    1610                 1615                 1620             


Cys Ile  Pro Asn Trp Lys Arg  Cys Asp Gly His Gln  Asp Cys Gln 
    1625                 1630                 1635             


Asp Gly  Arg Asp Glu Ala Asn  Cys Pro Thr His Ser  Thr Leu Thr 
    1640                 1645                 1650             


Cys Met  Ser Arg Glu Phe Gln  Cys Glu Asp Gly Glu  Ala Cys Ile 
    1655                 1660                 1665             


Val Leu  Ser Glu Arg Cys Asp  Gly Phe Leu Asp Cys  Ser Asp Glu 
    1670                 1675                 1680             


Ser Asp  Glu Lys Ala Cys Ser  Asp Glu Leu Thr Val  Tyr Lys Val 
    1685                 1690                 1695             


Gln Asn  Leu Gln Trp Thr Ala  Asp Phe Ser Gly Asp  Val Thr Leu 
    1700                 1705                 1710             


Thr Trp  Met Arg Pro Lys Lys  Met Pro Ser Ala Ser  Cys Val Tyr 
    1715                 1720                 1725             


Asn Val  Tyr Tyr Arg Val Val  Gly Glu Ser Ile Trp  Lys Thr Leu 
    1730                 1735                 1740             


Glu Thr  His Ser Asn Lys Thr  Asn Thr Val Leu Lys  Val Leu Lys 
    1745                 1750                 1755             


Pro Asp  Thr Thr Tyr Gln Val  Lys Val Gln Val Gln  Cys Leu Ser 
    1760                 1765                 1770             


Lys Ala  His Asn Thr Asn Asp  Phe Val Thr Leu Arg  Thr Pro Glu 
    1775                 1780                 1785             


Gly Leu  Pro Asp Ala Pro Arg  Asn Leu Gln Leu Ser  Leu Pro Arg 
    1790                 1795                 1800             


Glu Ala  Glu Gly Val Ile Val  Gly His Trp Ala Pro  Pro Ile His 
    1805                 1810                 1815             


Thr His  Gly Leu Ile Arg Glu  Tyr Ile Val Glu Tyr  Ser Arg Ser 
    1820                 1825                 1830             


Gly Ser  Lys Met Trp Ala Ser  Gln Arg Ala Ala Ser  Asn Phe Thr 
    1835                 1840                 1845             


Glu Ile  Lys Asn Leu Leu Val  Asn Thr Leu Tyr Thr  Val Arg Val 
    1850                 1855                 1860             


Ala Ala  Val Thr Ser Arg Gly  Ile Gly Asn Trp Ser  Asp Ser Lys 
    1865                 1870                 1875             


Ser Ile  Thr Thr Ile Lys Gly  Lys Val Ile Pro Pro  Pro Asp Ile 
    1880                 1885                 1890             


His Ile  Asp Ser Tyr Gly Glu  Asn Tyr Leu Ser Phe  Thr Leu Thr 
    1895                 1900                 1905             


Met Glu  Ser Asp Ile Lys Val  Asn Gly Tyr Val Val  Asn Leu Phe 
    1910                 1915                 1920             


Trp Ala  Phe Asp Thr His Lys  Gln Glu Arg Arg Thr  Leu Asn Phe 
    1925                 1930                 1935             


Arg Gly  Ser Ile Leu Ser His  Lys Val Gly Asn Leu  Thr Ala His 
    1940                 1945                 1950             


Thr Ser  Tyr Glu Ile Ser Ala  Trp Ala Lys Thr Asp  Leu Gly Asp 
    1955                 1960                 1965             


Ser Pro  Leu Ala Phe Glu His  Val Met Thr Arg Gly  Val Arg Pro 
    1970                 1975                 1980             


Pro Ala  Pro Ser Leu Lys Ala  Lys Ala Ile Asn Gln  Thr Ala Val 
    1985                 1990                 1995             


Glu Cys  Thr Trp Thr Gly Pro  Arg Asn Val Val Tyr  Gly Ile Phe 
    2000                 2005                 2010             


Tyr Ala  Thr Ser Phe Leu Asp  Leu Tyr Arg Asn Pro  Lys Ser Leu 
    2015                 2020                 2025             


Thr Thr  Ser Leu His Asn Lys  Thr Val Ile Val Ser  Lys Asp Glu 
    2030                 2035                 2040             


Gln Tyr  Leu Phe Leu Val Arg  Val Val Val Pro Tyr  Gln Gly Pro 
    2045                 2050                 2055             


Ser Ser  Asp Tyr Val Val Val  Lys Met Ile Pro Asp  Ser Arg Leu 
    2060                 2065                 2070             


Pro Pro  Arg His Leu His Val  Val His Thr Gly Lys  Thr Ser Val 
    2075                 2080                 2085             


Val Ile  Lys Trp Glu Ser Pro  Tyr Asp Ser Pro Asp  Gln Asp Leu 
    2090                 2095                 2100             


Leu Tyr  Ala Val Ala Val Lys  Asp Leu Ile Arg Lys  Thr Asp Arg 
    2105                 2110                 2115             


Ser Tyr  Lys Val Lys Ser Arg  Asn Ser Thr Val Glu  Tyr Thr Leu 
    2120                 2125                 2130             


Asn Lys  Leu Glu Pro Gly Gly  Lys Tyr His Ile Ile  Val Gln Leu 
    2135                 2140                 2145             


Gly Asn  Met Ser Lys Asp Ser  Ser Ile Lys Ile Thr  Thr Val Ser 
    2150                 2155                 2160             


Leu Ser  Ala Pro Asp Ala Leu  Lys Ile Ile Thr Glu  Asn Asp His 
    2165                 2170                 2175             


Val Leu  Leu Phe Trp Lys Ser  Leu Ala Leu Lys Glu  Lys His Phe 
    2180                 2185                 2190             


Asn Glu  Ser Arg Gly Tyr Glu  Ile His Met Phe Asp  Ser Ala Met 
    2195                 2200                 2205             


Asn Ile  Thr Ala Tyr Leu Gly  Asn Thr Thr Asp Asn  Phe Phe Lys 
    2210                 2215                 2220             


Ile Ser  Asn Leu Lys Met Gly  His Asn Tyr Thr Phe  Thr Val Gln 
    2225                 2230                 2235             


Ala Arg  Cys Leu Phe Gly Asn  Gln Ile Cys Gly Glu  Pro Ala Ile 
    2240                 2245                 2250             


Leu Leu  Tyr Asp Glu Leu Gly  Ser Gly Ala Asp Ala  Ser Ala Thr 
    2255                 2260                 2265             


Gln Ala  Ala Arg Ser Thr Asp  Val Ala Ala Val Val  Val Pro Ile 
    2270                 2275                 2280             


Leu Phe  Leu Ile Leu Leu Ser  Leu Gly Val Gly Phe  Ala Ile Leu 
    2285                 2290                 2295             


Tyr Thr  Lys His Arg Arg Leu  Gln Ser Ser Phe Thr  Ala Phe Ala 
    2300                 2305                 2310             


Asn Ser  His Tyr Ser Ser Arg  Leu Gly Ser Ala Ile  Phe Ser Ser 
    2315                 2320                 2325             


Gly Asp  Asp Leu Gly Glu Asp  Asp Glu Asp Ala Pro  Met Ile Thr 
    2330                 2335                 2340             


Gly Phe  Ser Asp Asp Val Pro  Met Val Ile Ala 
    2345                 2350                 


<210>  10
<211>  2133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(2133)
<223>  Human sortilin-related receptor 1_sorLA

<400>  10

Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val Ser 
1               5                   10                  15      


Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu Lys 
            20                  25                  30          


Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala Arg 
        35                  40                  45              


Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser Phe 
    50                  55                  60                  


Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser Glu 
65                  70                  75                  80  


Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg Tyr 
                85                  90                  95      


Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp Phe 
            100                 105                 110         


Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp Leu 
        115                 120                 125             


Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg Ser 
    130                 135                 140                 


His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr Trp 
145                 150                 155                 160 


Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp Pro 
                165                 170                 175     


Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser Gly 
            180                 185                 190         


Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu Asn 
        195                 200                 205             


Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp Lys 
    210                 215                 220                 


Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln Gln 
225                 230                 235                 240 


Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg Ala 
                245                 250                 255     


Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala Asp 
            260                 265                 270         


Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn Arg 
        275                 280                 285             


Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu Ser 
    290                 295                 300                 


Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp Thr 
305                 310                 315                 320 


Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg Val 
                325                 330                 335     


Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser Met 
            340                 345                 350         


Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly Thr 
        355                 360                 365             


Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys Ile 
    370                 375                 380                 


Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg Leu 
385                 390                 395                 400 


Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser Lys 
                405                 410                 415     


Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys Asn 
            420                 425                 430         


Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala Arg 
        435                 440                 445             


Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp His 
    450                 455                 460                 


Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu Leu 
465                 470                 475                 480 


Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe Ser 
                485                 490                 495     


Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu Lys 
            500                 505                 510         


Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His Ser 
        515                 520                 525             


Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro Cys 
    530                 535                 540                 


Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly Asn 
545                 550                 555                 560 


Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro His 
                565                 570                 575     


Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val Ser 
            580                 585                 590         


Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe Lys 
        595                 600                 605             


Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu Phe 
    610                 615                 620                 


Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser Thr 
625                 630                 635                 640 


Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys Ser 
                645                 650                 655     


Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys Pro 
            660                 665                 670         


Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser Ile 
        675                 680                 685             


Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu Thr 
    690                 695                 700                 


Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn Cys 
705                 710                 715                 720 


Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys Leu 
                725                 730                 735     


Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu Thr 
            740                 745                 750         


Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp Val 
        755                 760                 765             


Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp Phe 
    770                 775                 780                 


Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala Leu 
785                 790                 795                 800 


Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly Asp 
                805                 810                 815     


Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala Tyr 
            820                 825                 830         


His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val Asp 
        835                 840                 845             


Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu Arg 
    850                 855                 860                 


Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu Pro 
865                 870                 875                 880 


His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp Asp 
                885                 890                 895     


Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser Gln 
            900                 905                 910         


Met Glu Ile Leu Ala Asn Gln Leu Thr Gly Leu Met Asp Met Lys Ile 
        915                 920                 925             


Phe Tyr Lys Gly Lys Asn Thr Gly Ser Asn Ala Cys Val Pro Arg Pro 
    930                 935                 940                 


Cys Ser Leu Leu Cys Leu Pro Lys Ala Asn Asn Ser Arg Ser Cys Arg 
945                 950                 955                 960 


Cys Pro Glu Asp Val Ser Ser Ser Val Leu Pro Ser Gly Asp Leu Met 
                965                 970                 975     


Cys Asp Cys Pro Gln Gly Tyr Gln Leu Lys Asn Asn Thr Cys Val Lys 
            980                 985                 990         


Gln Glu Asn Thr Cys Leu Arg Asn  Gln Tyr Arg Cys Ser  Asn Gly Asn 
        995                 1000                 1005             


Cys Ile  Asn Ser Ile Trp Trp  Cys Asp Phe Asp Asn  Asp Cys Gly 
    1010                 1015                 1020             


Asp Met  Ser Asp Glu Arg Asn  Cys Pro Thr Thr Ile  Cys Asp Leu 
    1025                 1030                 1035             


Asp Thr  Gln Phe Arg Cys Gln  Glu Ser Gly Thr Cys  Ile Pro Leu 
    1040                 1045                 1050             


Ser Tyr  Lys Cys Asp Leu Glu  Asp Asp Cys Gly Asp  Asn Ser Asp 
    1055                 1060                 1065             


Glu Ser  His Cys Glu Met His  Gln Cys Arg Ser Asp  Glu Tyr Asn 
    1070                 1075                 1080             


Cys Ser  Ser Gly Met Cys Ile  Arg Ser Ser Trp Val  Cys Asp Gly 
    1085                 1090                 1095             


Asp Asn  Asp Cys Arg Asp Trp  Ser Asp Glu Ala Asn  Cys Thr Ala 
    1100                 1105                 1110             


Ile Tyr  His Thr Cys Glu Ala  Ser Asn Phe Gln Cys  Arg Asn Gly 
    1115                 1120                 1125             


His Cys  Ile Pro Gln Arg Trp  Ala Cys Asp Gly Asp  Thr Asp Cys 
    1130                 1135                 1140             


Gln Asp  Gly Ser Asp Glu Asp  Pro Val Asn Cys Glu  Lys Lys Cys 
    1145                 1150                 1155             


Asn Gly  Phe Arg Cys Pro Asn  Gly Thr Cys Ile Pro  Ser Ser Lys 
    1160                 1165                 1170             


His Cys  Asp Gly Leu Arg Asp  Cys Ser Asp Gly Ser  Asp Glu Gln 
    1175                 1180                 1185             


His Cys  Glu Pro Leu Cys Thr  His Phe Met Asp Phe  Val Cys Lys 
    1190                 1195                 1200             


Asn Arg  Gln Gln Cys Leu Phe  His Ser Met Val Cys  Asp Gly Ile 
    1205                 1210                 1215             


Ile Gln  Cys Arg Asp Gly Ser  Asp Glu Asp Ala Ala  Phe Ala Gly 
    1220                 1225                 1230             


Cys Ser  Gln Asp Pro Glu Phe  His Lys Val Cys Asp  Glu Phe Gly 
    1235                 1240                 1245             


Phe Gln  Cys Gln Asn Gly Val  Cys Ile Ser Leu Ile  Trp Lys Cys 
    1250                 1255                 1260             


Asp Gly  Met Asp Asp Cys Gly  Asp Tyr Ser Asp Glu  Ala Asn Cys 
    1265                 1270                 1275             


Glu Asn  Pro Thr Glu Ala Pro  Asn Cys Ser Arg Tyr  Phe Gln Phe 
    1280                 1285                 1290             


Arg Cys  Glu Asn Gly His Cys  Ile Pro Asn Arg Trp  Lys Cys Asp 
    1295                 1300                 1305             


Arg Glu  Asn Asp Cys Gly Asp  Trp Ser Asp Glu Lys  Asp Cys Gly 
    1310                 1315                 1320             


Asp Ser  His Ile Leu Pro Phe  Ser Thr Pro Gly Pro  Ser Thr Cys 
    1325                 1330                 1335             


Leu Pro  Asn Tyr Tyr Arg Cys  Ser Ser Gly Thr Cys  Val Met Asp 
    1340                 1345                 1350             


Thr Trp  Val Cys Asp Gly Tyr  Arg Asp Cys Ala Asp  Gly Ser Asp 
    1355                 1360                 1365             


Glu Glu  Ala Cys Pro Leu Leu  Ala Asn Val Thr Ala  Ala Ser Thr 
    1370                 1375                 1380             


Pro Thr  Gln Leu Gly Arg Cys  Asp Arg Phe Glu Phe  Glu Cys His 
    1385                 1390                 1395             


Gln Pro  Lys Thr Cys Ile Pro  Asn Trp Lys Arg Cys  Asp Gly His 
    1400                 1405                 1410             


Gln Asp  Cys Gln Asp Gly Arg  Asp Glu Ala Asn Cys  Pro Thr His 
    1415                 1420                 1425             


Ser Thr  Leu Thr Cys Met Ser  Arg Glu Phe Gln Cys  Glu Asp Gly 
    1430                 1435                 1440             


Glu Ala  Cys Ile Val Leu Ser  Glu Arg Cys Asp Gly  Phe Leu Asp 
    1445                 1450                 1455             


Cys Ser  Asp Glu Ser Asp Glu  Lys Ala Cys Ser Asp  Glu Leu Thr 
    1460                 1465                 1470             


Val Tyr  Lys Val Gln Asn Leu  Gln Trp Thr Ala Asp  Phe Ser Gly 
    1475                 1480                 1485             


Asp Val  Thr Leu Thr Trp Met  Arg Pro Lys Lys Met  Pro Ser Ala 
    1490                 1495                 1500             


Ser Cys  Val Tyr Asn Val Tyr  Tyr Arg Val Val Gly  Glu Ser Ile 
    1505                 1510                 1515             


Trp Lys  Thr Leu Glu Thr His  Ser Asn Lys Thr Asn  Thr Val Leu 
    1520                 1525                 1530             


Lys Val  Leu Lys Pro Asp Thr  Thr Tyr Gln Val Lys  Val Gln Val 
    1535                 1540                 1545             


Gln Cys  Leu Ser Lys Ala His  Asn Thr Asn Asp Phe  Val Thr Leu 
    1550                 1555                 1560             


Arg Thr  Pro Glu Gly Leu Pro  Asp Ala Pro Arg Asn  Leu Gln Leu 
    1565                 1570                 1575             


Ser Leu  Pro Arg Glu Ala Glu  Gly Val Ile Val Gly  His Trp Ala 
    1580                 1585                 1590             


Pro Pro  Ile His Thr His Gly  Leu Ile Arg Glu Tyr  Ile Val Glu 
    1595                 1600                 1605             


Tyr Ser  Arg Ser Gly Ser Lys  Met Trp Ala Ser Gln  Arg Ala Ala 
    1610                 1615                 1620             


Ser Asn  Phe Thr Glu Ile Lys  Asn Leu Leu Val Asn  Thr Leu Tyr 
    1625                 1630                 1635             


Thr Val  Arg Val Ala Ala Val  Thr Ser Arg Gly Ile  Gly Asn Trp 
    1640                 1645                 1650             


Ser Asp  Ser Lys Ser Ile Thr  Thr Ile Lys Gly Lys  Val Ile Pro 
    1655                 1660                 1665             


Pro Pro  Asp Ile His Ile Asp  Ser Tyr Gly Glu Asn  Tyr Leu Ser 
    1670                 1675                 1680             


Phe Thr  Leu Thr Met Glu Ser  Asp Ile Lys Val Asn  Gly Tyr Val 
    1685                 1690                 1695             


Val Asn  Leu Phe Trp Ala Phe  Asp Thr His Lys Gln  Glu Arg Arg 
    1700                 1705                 1710             


Thr Leu  Asn Phe Arg Gly Ser  Ile Leu Ser His Lys  Val Gly Asn 
    1715                 1720                 1725             


Leu Thr  Ala His Thr Ser Tyr  Glu Ile Ser Ala Trp  Ala Lys Thr 
    1730                 1735                 1740             


Asp Leu  Gly Asp Ser Pro Leu  Ala Phe Glu His Val  Met Thr Arg 
    1745                 1750                 1755             


Gly Val  Arg Pro Pro Ala Pro  Ser Leu Lys Ala Lys  Ala Ile Asn 
    1760                 1765                 1770             


Gln Thr  Ala Val Glu Cys Thr  Trp Thr Gly Pro Arg  Asn Val Val 
    1775                 1780                 1785             


Tyr Gly  Ile Phe Tyr Ala Thr  Ser Phe Leu Asp Leu  Tyr Arg Asn 
    1790                 1795                 1800             


Pro Lys  Ser Leu Thr Thr Ser  Leu His Asn Lys Thr  Val Ile Val 
    1805                 1810                 1815             


Ser Lys  Asp Glu Gln Tyr Leu  Phe Leu Val Arg Val  Val Val Pro 
    1820                 1825                 1830             


Tyr Gln  Gly Pro Ser Ser Asp  Tyr Val Val Val Lys  Met Ile Pro 
    1835                 1840                 1845             


Asp Ser  Arg Leu Pro Pro Arg  His Leu His Val Val  His Thr Gly 
    1850                 1855                 1860             


Lys Thr  Ser Val Val Ile Lys  Trp Glu Ser Pro Tyr  Asp Ser Pro 
    1865                 1870                 1875             


Asp Gln  Asp Leu Leu Tyr Ala  Val Ala Val Lys Asp  Leu Ile Arg 
    1880                 1885                 1890             


Lys Thr  Asp Arg Ser Tyr Lys  Val Lys Ser Arg Asn  Ser Thr Val 
    1895                 1900                 1905             


Glu Tyr  Thr Leu Asn Lys Leu  Glu Pro Gly Gly Lys  Tyr His Ile 
    1910                 1915                 1920             


Ile Val  Gln Leu Gly Asn Met  Ser Lys Asp Ser Ser  Ile Lys Ile 
    1925                 1930                 1935             


Thr Thr  Val Ser Leu Ser Ala  Pro Asp Ala Leu Lys  Ile Ile Thr 
    1940                 1945                 1950             


Glu Asn  Asp His Val Leu Leu  Phe Trp Lys Ser Leu  Ala Leu Lys 
    1955                 1960                 1965             


Glu Lys  His Phe Asn Glu Ser  Arg Gly Tyr Glu Ile  His Met Phe 
    1970                 1975                 1980             


Asp Ser  Ala Met Asn Ile Thr  Ala Tyr Leu Gly Asn  Thr Thr Asp 
    1985                 1990                 1995             


Asn Phe  Phe Lys Ile Ser Asn  Leu Lys Met Gly His  Asn Tyr Thr 
    2000                 2005                 2010             


Phe Thr  Val Gln Ala Arg Cys  Leu Phe Gly Asn Gln  Ile Cys Gly 
    2015                 2020                 2025             


Glu Pro  Ala Ile Leu Leu Tyr  Asp Glu Leu Gly Ser  Gly Ala Asp 
    2030                 2035                 2040             


Ala Ser  Ala Thr Gln Ala Ala  Arg Ser Thr Asp Val  Ala Ala Val 
    2045                 2050                 2055             


Val Val  Pro Ile Leu Phe Leu  Ile Leu Leu Ser Leu  Gly Val Gly 
    2060                 2065                 2070             


Phe Ala  Ile Leu Tyr Thr Lys  His Arg Arg Leu Gln  Ser Ser Phe 
    2075                 2080                 2085             


Thr Ala  Phe Ala Asn Ser His  Tyr Ser Ser Arg Leu  Gly Ser Ala 
    2090                 2095                 2100             


Ile Phe  Ser Ser Gly Asp Asp  Leu Gly Glu Asp Asp  Glu Asp Ala 
    2105                 2110                 2115             


Pro Met  Ile Thr Gly Phe Ser  Asp Asp Val Pro Met  Val Ile Ala 
    2120                 2125                 2130             


<210>  11
<211>  506
<212>  PRT
<213>  Artificial

<220>
<223>  reporter


<220>
<221>  MISC_FEATURE
<222>  (1)..(506)
<223>  SEAP reporter

<400>  11

Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu 
            20                  25                  30          


Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr 
        35                  40                  45              


Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser 
    50                  55                  60                  


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu 
65                  70                  75                  80  


Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu 
                85                  90                  95      


Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr 
            100                 105                 110         


Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly 
        115                 120                 125             


Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn 
    130                 135                 140                 


Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val 
145                 150                 155                 160 


Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr 
                165                 170                 175     


Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro 
            180                 185                 190         


Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile 
        195                 200                 205             


Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met 
    210                 215                 220                 


Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln 
225                 230                 235                 240 


Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala 
                245                 250                 255     


Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln 
            260                 265                 270         


Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro 
        275                 280                 285             


Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser 
    290                 295                 300                 


Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro 
305                 310                 315                 320 


Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His 
                325                 330                 335     


His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp 
            340                 345                 350         


Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu 
        355                 360                 365             


Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr 
    370                 375                 380                 


Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg 
385                 390                 395                 400 


Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr 
                405                 410                 415     


Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly 
            420                 425                 430         


Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr 
        435                 440                 445             


His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His 
    450                 455                 460                 


Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala 
465                 470                 475                 480 


Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro 
                485                 490                 495     


Ala Gly Thr Thr Asp Ala Ala His Pro Gly 
            500                 505     


<210>  12
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  linker

<400>  12

Leu Ser Arg Ser Glu 
1               5   


<210>  13
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(8)
<223>  linker

<400>  13

Leu Ser Arg Ser Ser Gly Gly Glu 
1               5               


<210>  14
<211>  53
<212>  PRT
<213>  Artificial

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (1)..(53)
<223>  linker

<400>  14

Glu Val Trp Thr Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln 
1               5                   10                  15      


Asp Arg Gly Phe Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu 
            20                  25                  30          


Trp Ala Arg Gly Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro 
        35                  40                  45              


Leu Gly Ser Gly Ser 
    50              


<210>  15
<211>  168
<212>  PRT
<213>  Artificial

<220>
<223>  reporter


<220>
<221>  MISC_FEATURE
<222>  (1)..(168)
<223>  eGluc reporter

<400>  15

Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala Ser 
1               5                   10                  15      


Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro Gly 
            20                  25                  30          


Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Ile Glu Ala Asn Ala Arg 
        35                  40                  45              


Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile Lys 
    50                  55                  60                  


Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr Tyr 
65                  70                  75                  80  


Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly Glu Ala Ile Val 
                85                  90                  95      


Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu Pro Ile Glu Gln 
            100                 105                 110         


Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr Thr Gly Cys Leu 
        115                 120                 125             


Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu Lys Lys Trp Leu 
    130                 135                 140                 


Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln Gly Gln Val Asp 
145                 150                 155                 160 


Lys Ile Lys Gly Ala Gly Gly Asp 
                165             


<210>  16
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  cleavage site for Furin

<400>  16

Arg Arg Lys Arg 
1               


<210>  17
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  substituted cleavage site for Furin


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  Substituted cleavage site for Furin

<400>  17

Gly Ser Gly Ser 
1               


