                         SEQUENCE LISTING

<110>  Biocytogen PharmaceuticalsBeijingCo., Ltd.
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL EXPRESSING A B2M/FCRN 
       FUSION PROTEIN

<130>  1

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  858
<212>  DNA
<213>  Mus musculus

<400>  1
tttcagtggc tgctactcgg cgcttcagtc gcggtcgctt cagtcgtcag catggctcgc       60

tcggtgaccc tggtctttct ggtgcttgtc tcactgaccg gcctgtatgc tatccagaaa      120

acccctcaaa ttcaagtata ctcacgccac ccaccggaga atgggaagcc gaacatactg      180

aactgctacg taacacagtt ccacccgcct cacattgaaa tccaaatgct gaagaacggg      240

aaaaaaattc ctaaagtaga gatgtcagat atgtccttca gcaaggactg gtctttctat      300

atcctggctc acactgaatt cacccccact gagactgata catacgcctg cagagttaag      360

catgccagta tggccgagcc caagaccgtc tactgggatc gagacatgtg atcaagcatc      420

atgatgctct gaagattcat ttgaacctgc ttaattacaa atccagtttc taatatgcta      480

tacaatttat gcacgcagaa agaaatagca atgtacacat caccttcttt atatcttact      540

ttaaatattt tatgcatgtt ttcaaaaaat tggaaatatc ctagatagct gagcaataaa      600

tcttcaataa gtattttgat cagaataata aatataattt taagaacaat agttgatcat      660

atgccaaacc ctctgtactt ctcattactt ggatgcagtt actcatcttt ggtctatcac      720

aacataagtg acatactttc cttttggtaa agcaaagagg cctaattgaa gtctgtcact      780

gtgcccaatg cttagcaatt ctcaccccca accctgtggc tacttctgct tttgttactt      840

ttactaaaaa taaaaaac                                                    858


<210>  2
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr 
        35                  40                  45              


Gln Phe His Pro Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys 
    50                  55                  60                  


Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp 
                85                  90                  95      


Thr Tyr Ala Cys Arg Val Lys His Ala Ser Met Ala Glu Pro Lys Thr 
            100                 105                 110         


Val Tyr Trp Asp Arg Asp Met 
        115                 


<210>  3
<211>  1738
<212>  DNA
<213>  Mus musculus

<400>  3
aggagctagt gggtggagtt ggatgccctc agagttctcc agtcctaact gtgtacagac       60

aggatgtaag agaagaactg gaggctctaa gcagaggatc catcggctgc aggcagaggg      120

aagagggcct ctgtgaggaa caggctgagc gtcagaggag gaggcccagg cctggttctc      180

tagctctgta attaattaac taaagtggat caaatgagaa ggtgaaagtt cacagaggaa      240

cactcctgtc tgtcgtcttg gactgggtct ccatcccacc atccagcgtc ctggtctacg      300

aagagtccac agggaccttg tgaagaatca acaaggcggg gtccagagga gtcacgtgtc      360

ccttccactc cgggtcaccc tgtcggaatg gggatgccac tgccctgggc cctcagcctc      420

ttgttggtcc tcctgcctca gacctggggc tcagagaccc gccccccact gatgtatcat      480

ctcacggctg tgtcaaaccc atctacgggg cttccctctt tctgggctac aggctggttg      540

ggtcctcagc agtatctgac ctacaacagc ctgcggcagg aagctgaccc ctgtggggcc      600

tggatgtggg aaaatcaggt gtcttggtat tgggagaagg agaccacaga cctcaaaagc      660

aaagaacagc tcttcttgga ggccctcaag accctggaga agatattaaa tgggacctac      720

acactgcagg gcctgctggg ctgtgaactg gcctcggata attcctcagt gcccacggct      780

gtgtttgccc tcaatggtga ggagtttatg aaattcaacc caagaatcgg caattggact      840

ggggagtggc ctgagacgga aatcgttgct aatctgtgga tgaagcagcc tgatgcggcc      900

aggaaggaga gcgagttcct gctaaactct tgtccggagc gactgctagg ccacctggag      960

aggggccgac ggaacctgga gtggaaggag ccgccgtcta tgcgcctgaa ggcccgtcct     1020

ggcaactctg gctcctccgt gctgacctgt gctgctttct ccttctaccc accggagctc     1080

aagttccgat tcctgcgcaa tgggctagcc tcaggctccg ggaattgcag cactggtccc     1140

aatggagatg gctctttcca cgcatggtca ttgctggagg tcaaacgtgg agatgagcac     1200

cattatcaat gtcaagtgga gcatgagggg ctggcacagc ctctcactgt ggacctagat     1260

tcatcagcca gatcttctgt gcctgtggtt ggaatcgttc ttggtttatt gctggtggta     1320

gtggccatcg caggcggtgt gctgttgtgg ggcaggatgc gcagcggtct gccagcccca     1380

tggctttctc tcagcggcga tgactctggt gacctgttgc ctggtgggaa cttgccccca     1440

gaagctgaac ctcaaggtgc aaatgccttt ccagccactt cctgatgcag actcgggccc     1500

cctgcccact gcagcctttc gggctgtgtg acctcctgaa ctgtctccga gcctcctgag     1560

ggagcctggg cccgatgtcc tcccatggat ccctgctttt gtggcctgct tcagtttccc     1620

ttcttaatgt acatggttgt tttccatctc cacataaatt tggccccaaa tctgtgtgtg     1680

catcgttatt ctcaagtttc aagcagctgg aataaattga acgcgtctgg gaaagatc       1738


<210>  4
<211>  365
<212>  PRT
<213>  Mus musculus

<400>  4

Met Gly Met Pro Leu Pro Trp Ala Leu Ser Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Pro Gln Thr Trp Gly Ser Glu Thr Arg Pro Pro Leu Met Tyr His Leu 
            20                  25                  30          


Thr Ala Val Ser Asn Pro Ser Thr Gly Leu Pro Ser Phe Trp Ala Thr 
        35                  40                  45              


Gly Trp Leu Gly Pro Gln Gln Tyr Leu Thr Tyr Asn Ser Leu Arg Gln 
    50                  55                  60                  


Glu Ala Asp Pro Cys Gly Ala Trp Met Trp Glu Asn Gln Val Ser Trp 
65                  70                  75                  80  


Tyr Trp Glu Lys Glu Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu Phe 
                85                  90                  95      


Leu Glu Ala Leu Lys Thr Leu Glu Lys Ile Leu Asn Gly Thr Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Ala Ser Asp Asn Ser Ser Val 
        115                 120                 125             


Pro Thr Ala Val Phe Ala Leu Asn Gly Glu Glu Phe Met Lys Phe Asn 
    130                 135                 140                 


Pro Arg Ile Gly Asn Trp Thr Gly Glu Trp Pro Glu Thr Glu Ile Val 
145                 150                 155                 160 


Ala Asn Leu Trp Met Lys Gln Pro Asp Ala Ala Arg Lys Glu Ser Glu 
                165                 170                 175     


Phe Leu Leu Asn Ser Cys Pro Glu Arg Leu Leu Gly His Leu Glu Arg 
            180                 185                 190         


Gly Arg Arg Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Gly Asn Ser Gly Ser Ser Val Leu Thr Cys Ala Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ser Gly Ser Gly Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly Ser 
                245                 250                 255     


Phe His Ala Trp Ser Leu Leu Glu Val Lys Arg Gly Asp Glu His His 
            260                 265                 270         


Tyr Gln Cys Gln Val Glu His Glu Gly Leu Ala Gln Pro Leu Thr Val 
        275                 280                 285             


Asp Leu Asp Ser Ser Ala Arg Ser Ser Val Pro Val Val Gly Ile Val 
    290                 295                 300                 


Leu Gly Leu Leu Leu Val Val Val Ala Ile Ala Gly Gly Val Leu Leu 
305                 310                 315                 320 


Trp Gly Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Leu Ser Leu Ser 
                325                 330                 335     


Gly Asp Asp Ser Gly Asp Leu Leu Pro Gly Gly Asn Leu Pro Pro Glu 
            340                 345                 350         


Ala Glu Pro Gln Gly Ala Asn Ala Phe Pro Ala Thr Ser 
        355                 360                 365 


<210>  5
<211>  2080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified FcRn mRNA

<400>  5
aggagctagt gggtggagtt ggatgccctc agagttctcc agtcctaact gtgtacagac       60

aggatgtaag agaagaactg gaggctctaa gcagaggatc catcggctgc aggcagaggg      120

aagagggcct ctgtgaggaa caggctgagc gtcagaggag gaggcccagg cctggttctc      180

tagctctgta attaattaac taaagtggat caaatgagaa ggtgaaagtt cacagaggaa      240

cactcctgtc tgtcgtcttg gactgggtct ccatcccacc atccagcgtc ctggtctacg      300

aagagtccac agggaccttg tgaagaatca acaaggcggg gtccagagga gtcacgtgtc      360

ccttccactc cgggtcaccc tgtcggaatg gggatgccac tgccctgggc cctcagcctc      420

ttgttggtcc tcctgcctca gacctggggc atccagaaaa cccctcaaat tcaagtatac      480

tcacgccacc caccggagaa tgggaagccg aacatactga actgctacgt aacacagttc      540

cacccgcctc acattgaaat ccaaatgctg aagaacggga aaaaaattcc taaagtagag      600

atgtcagata tgtccttcag caaggactgg tctttctata tcctggctca cactgaattc      660

acccccactg agactgatac atacgcctgc agagttaagc atgccagtat ggccgagccc      720

aagaccgtct actgggatcg agacatggga ggtggcggat ccggcggagg cggctcgggt      780

ggcggcggct cttcagagac ccgcccccca ctgatgtatc atctcacggc tgtgtcaaac      840

ccatctacgg ggcttccctc tttctgggct acaggctggt tgggtcctca gcagtatctg      900

acctacaaca gcctgcggca ggaagctgac ccctgtgggg cctggatgtg ggaaaatcag      960

gtgtcttggt attgggagaa ggagaccaca gacctcaaaa gcaaagaaca gctcttcttg     1020

gaggccctca agaccctgga gaagatatta aatgggacct acacactgca gggcctgctg     1080

ggctgtgaac tggcctcgga taattcctca gtgcccacgg ctgtgtttgc cctcaatggt     1140

gaggagttta tgaaattcaa cccaagaatc ggcaattgga ctggggagtg gcctgagacg     1200

gaaatcgttg ctaatctgtg gatgaagcag cctgatgcgg ccaggaagga gagcgagttc     1260

ctgctaaact cttgtccgga gcgactgcta ggccacctgg agaggggccg acggaacctg     1320

gagtggaagg agccgccgtc tatgcgcctg aaggcccgtc ctggcaactc tggctcctcc     1380

gtgctgacct gtgctgcttt ctccttctac ccaccggagc tcaagttccg attcctgcgc     1440

aatgggctag cctcaggctc cgggaattgc agcactggtc ccaatggaga tggctctttc     1500

cacgcatggt cattgctgga ggtcaaacgt ggagatgagc accattatca atgtcaagtg     1560

gagcatgagg ggctggcaca gcctctcact gtggacctag attcatcagc cagatcttct     1620

gtgcctgtgg ttggaatcgt tcttggttta ttgctggtgg tagtggccat cgcaggcggt     1680

gtgctgttgt ggggcaggat gcgcagcggt ctgccagccc catggctttc tctcagcggc     1740

gatgactctg gtgacctgtt gcctggtggg aacttgcccc cagaagctga acctcaaggt     1800

gcaaatgcct ttccagccac ttcctgatgc agactcgggc cccctgccca ctgcagcctt     1860

tcgggctgtg tgacctcctg aactgtctcc gagcctcctg agggagcctg ggcccgatgt     1920

cctcccatgg atccctgctt ttgtggcctg cttcagtttc ccttcttaat gtacatggtt     1980

gttttccatc tccacataaa tttggcccca aatctgtgtg tgcatcgtta ttctcaagtt     2040

tcaagcagct ggaataaatt gaacgcgtct gggaaagatc                           2080


<210>  6
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified FcRn protein

<400>  6

Met Gly Met Pro Leu Pro Trp Ala Leu Ser Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Pro Gln Thr Trp Gly Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser 
            20                  25                  30          


Arg His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val 
        35                  40                  45              


Thr Gln Phe His Pro Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly 
    50                  55                  60                  


Lys Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp 
65                  70                  75                  80  


Trp Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr 
                85                  90                  95      


Asp Thr Tyr Ala Cys Arg Val Lys His Ala Ser Met Ala Glu Pro Lys 
            100                 105                 110         


Thr Val Tyr Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Ser Glu Thr Arg Pro Pro Leu Met Tyr 
    130                 135                 140                 


His Leu Thr Ala Val Ser Asn Pro Ser Thr Gly Leu Pro Ser Phe Trp 
145                 150                 155                 160 


Ala Thr Gly Trp Leu Gly Pro Gln Gln Tyr Leu Thr Tyr Asn Ser Leu 
                165                 170                 175     


Arg Gln Glu Ala Asp Pro Cys Gly Ala Trp Met Trp Glu Asn Gln Val 
            180                 185                 190         


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Lys Ser Lys Glu Gln 
        195                 200                 205             


Leu Phe Leu Glu Ala Leu Lys Thr Leu Glu Lys Ile Leu Asn Gly Thr 
    210                 215                 220                 


Tyr Thr Leu Gln Gly Leu Leu Gly Cys Glu Leu Ala Ser Asp Asn Ser 
225                 230                 235                 240 


Ser Val Pro Thr Ala Val Phe Ala Leu Asn Gly Glu Glu Phe Met Lys 
                245                 250                 255     


Phe Asn Pro Arg Ile Gly Asn Trp Thr Gly Glu Trp Pro Glu Thr Glu 
            260                 265                 270         


Ile Val Ala Asn Leu Trp Met Lys Gln Pro Asp Ala Ala Arg Lys Glu 
        275                 280                 285             


Ser Glu Phe Leu Leu Asn Ser Cys Pro Glu Arg Leu Leu Gly His Leu 
    290                 295                 300                 


Glu Arg Gly Arg Arg Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg 
305                 310                 315                 320 


Leu Lys Ala Arg Pro Gly Asn Ser Gly Ser Ser Val Leu Thr Cys Ala 
                325                 330                 335     


Ala Phe Ser Phe Tyr Pro Pro Glu Leu Lys Phe Arg Phe Leu Arg Asn 
            340                 345                 350         


Gly Leu Ala Ser Gly Ser Gly Asn Cys Ser Thr Gly Pro Asn Gly Asp 
        355                 360                 365             


Gly Ser Phe His Ala Trp Ser Leu Leu Glu Val Lys Arg Gly Asp Glu 
    370                 375                 380                 


His His Tyr Gln Cys Gln Val Glu His Glu Gly Leu Ala Gln Pro Leu 
385                 390                 395                 400 


Thr Val Asp Leu Asp Ser Ser Ala Arg Ser Ser Val Pro Val Val Gly 
                405                 410                 415     


Ile Val Leu Gly Leu Leu Leu Val Val Val Ala Ile Ala Gly Gly Val 
            420                 425                 430         


Leu Leu Trp Gly Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Leu Ser 
        435                 440                 445             


Leu Ser Gly Asp Asp Ser Gly Asp Leu Leu Pro Gly Gly Asn Leu Pro 
    450                 455                 460                 


Pro Glu Ala Glu Pro Gln Gly Ala Asn Ala Phe Pro Ala Thr Ser 
465                 470                 475                 


<210>  7
<211>  1480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5 homologous arm

<400>  7
ggttttgccc atctacttca gcctgttggt ccatctgctg accaccagtc gaccactcac       60

ggctctgtca gtctccctct ctcggctgtt tatattccct gccgcccagg ccggccatga      120

acccctggcc tcccggcctc catccttagt gctggaatta caggcatgtg ctgccgccca      180

ccccctttct tctttgctgt ctatctaccc tgtcaaccta cctgtctgtc agtgtctctc      240

tgtgtgtctg tgtgtttttt ctggcaagat cttggggtgg gcagcagggt gggagacagg      300

ggccaaaggc aaaggctctc atcacagagt gtgtaggcag ggttggggcc acctcaagtg      360

ctggcacatg gaagaaatca gagcaggctt acagctggga gtgggctgct gccaaacctt      420

gtgtgttagg caaccatgcc atgaccaagc cacacccaca gcccacaaat cctggggtgt      480

cttaaagtca cattcagcgt gcaggccttt ccagggctgc gagtctactc caaaaatgct      540

ccaaacgagt aaacatagaa gctgttttgg gaggcaggcc taatgacgtt tgccccggga      600

ggcttccaac cagatacagc aggaacttca agagaggctg gacagaggcc caaggggtgt      660

gcttaggagc tagtgggtgg agttggatgc cctcagagtt ctccagtcct aactgtgtac      720

agacaggatg taagagaaga actggaggct ctaagcagag gatccatcgg ctgcaggcag      780

agggaagagg gcctctgtga ggaacaggct gagcgtcaga ggaggaggcc caggcctggt      840

tctctaggta tgagggacca gcaccccaag aggaaagagg gttggggcct ggagctccag      900

gtctgaggga ggagtgttat gacctgaggg ggagagagga ggctggggtc tgaggaagga      960

gagcaggacc ccgggcacct gagtctgagg gatgaagccg gagcctaggg ttttgggttt     1020

gaggaaagat cttggaactg gactcctgga tctgagggag gtggaactgg actcctggct     1080

tgggtttgag ggctcctgag gctgaaatct gagcccctgg gaatgaggga ggaggagaag     1140

gcctggatcc tctggtctga gggaggagaa aaaggaaata acagaagtct gagacaaatt     1200

ttggtctgtc tagctctgta attaattaac taaagtggat caaatgagaa ggtgaaagtt     1260

cacagaggaa cactcctgtc tgtcgtcttg gactgggtct ccatcccacc atccagcgtc     1320

ctggtctacg aagagtccac agggaccttg tgaagaatca acaaggcggg gtccagagga     1380

gtcacgtgtc ccttccactc cgggtcaccc tgtcggaatg gggatgccac tgccatgggc     1440

gctcagcctc ttgttggtcc tcctgcctca gacctggggc                           1480


<210>  8
<211>  1445
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3 homologous arm

<400>  8
tcaggtaaga ggccaccagg acctggagtg tgtcaggaag gggacaggaa gaagagccaa       60

agagtggaag agggacaata agtccacttt ttccatgatg tcctagcctt catggaaatc      120

tcactgtggg taacttctct gtgcatctga gtcaaataca cttgacaatc tcaggctcgt      180

ctctgtgtcc gtctgtccgt cttgcttcct ttctgggtgt ctgtcccctt ctctctggag      240

gatcatggca cttcagatcg ggtccagttt tcattctgca cctctgtggg gcacggtgca      300

gtccgtgacc cgagactctc ctgtttgctc tgcagagacc cgccccccac tgatgtatca      360

tctcacggct gtgtcaaacc catctacggg gcttccctct ttctgggcta caggctggtt      420

gggtcctcag cagtatctga cctacaacag cctgcggcag gaagctgacc cctgtggggc      480

ctggatgtgg gaaaatcagg tgtcttggta ttgggagaag gagaccacag acctcaaaag      540

caaagaacag ctcttcttgg aggccctcaa gaccctggag aagatattaa atggtcagaa      600

gaggggtgag cttcagtagg ctgggtttga ggaaggataa tgggtctgga ttcctgggtc      660

aaggaaggag gctggagccc taggcctgaa gtgggaggat taggtctgaa ccctaggaat      720

aagggggaag gttgggatct ggacctcaag gtccgaggga ggagaagaga ggaaggctgg      780

cccttgctcc tgagtctgct tgcctgcgtg ttggcatcta gggacctaca cactgcaggg      840

cctgctgggc tgtgaactgg cctcggataa ttcctcagtg cccacggctg tgtttgccct      900

caatggtgag gagtttatga aattcaaccc aagaatcggc aattggactg gggagtggcc      960

tgagacggaa atcgttgcta atctgtggat gaagcagcct gatgcggcca ggaaggagag     1020

cgagttcctg ctaaactctt gtccggagcg actgctaggc cacctggaga ggggccgacg     1080

gaacctggag tggaagggtg agcccatctc ctgtccctcc tctagatctc cacagccatg     1140

ctcaaagccc acccagcatc agtacaaccc ctctcgccta tcccagtgga tcttctttaa     1200

gataaggtct catgtagccc aggctagctc tcacgtagct caagctagcc atgagctcat     1260

cgtgtagctg aggatggtct tggattcctg atcctcttag cccattccaa gtgctgattt     1320

gacttaagtg tgttgccaca cccagctaat tgttcttgtt tgtgagacag ggtctcaggc     1380

tgactttgaa ctcagagaga tctcttgagt gctgggacaa aaggagtgtg ctgctgtacc     1440

aggct                                                                 1445


<210>  9
<211>  297
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M sequence in A fragment

<400>  9
atccagaaaa cccctcaaat tcaagtatac tcacgccacc caccggagaa tgggaagccg       60

aacatactga actgctacgt aacacagttc cacccgcctc acattgaaat ccaaatgctg      120

aagaacggga aaaaaattcc taaagtagag atgtcagata tgtccttcag caaggactgg      180

tctttctata tcctggctca cactgaattc acccccactg agactgatac atatgcctgc      240

agagttaagc atgccagtat ggccgagccc aagaccgtct actgggatcg agacatg         297


<210>  10
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  10
ggaggtggcg gatccggcgg aggcggctcg ggtggcggcg gctct                       45


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA target sequence

<400>  11
cgggtcaccc tgtcggaatg ggg                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA target sequence

<400>  12
cccattccga cagggtgacc cgg                                               23


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA target sequence

<400>  13
agtggcatcc ccattccgac agg                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA target sequence

<400>  14
ccatgatgtc ctagccttca tgg                                               23


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA target sequence

<400>  15
ctgagcccca ggtctgaggc agg                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA target sequence

<400>  16
ggaggaccaa caagaggctg agg                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA target sequence

<400>  17
gagtgtgtca ggaaggggac agg                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA target sequence

<400>  18
ttacctgagc cccaggtctg agg                                               23


<210>  19
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  19
gtttgaggaa ggataatggg tctgg                                             25


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  20
ggaggaccaa caagaggctg                                                   20


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  21
taggggagga ccaacaagag gctg                                              24


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  22
cagcctcttg ttggtcctcc                                                   20


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA sequence

<400>  23
aaaccagcct cttgttggtc ctcc                                              24


<210>  24
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pT7-sgRNA vector

<400>  24
gaattctaat acgactcact atagggggtc ttcgagaaga cctgttttag agctagaaat       60

agcaagttaa aataaggcta gtccgttatc aacttgaaaa agtggcaccg agtcggtgct      120

tttaaaggat cc                                                          132


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  25
gtagctgtct tcagacactc cagaa                                             25


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  26
tgcaggcata tgtatcagtc tcagt                                             25


<210>  27
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  27
aattcaagta tactcacgcc accca                                             25


<210>  28
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  28
taagttcaag tcccagcaac cacat                                             25


<210>  29
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  29
ttgcttctgt ctttcaagtg tgtggg                                            26


<210>  30
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  30
attcaagtat actcacgcca cccacc                                            26


<210>  31
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  31
aggctgagac caagaggatg acaag                                             25


<210>  32
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  32
ctgcttccct ctttcctgag cttcc                                             25


<210>  33
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  33
aaacccatgc aggctgtgta actga                                             25


<210>  34
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  34
gaataaatga aggcggtccc aggct                                             25


<210>  35
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  35
acgagcctga gattgtcaag tgtat                                             25


<210>  36
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  36
gtgaaagttc acagaggaac actcc                                             25


<210>  37
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  37
catccacaga ttagcaacga tttcc                                             25


<210>  38
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  38
gctagcatca gaagatcagg actca                                             25


<210>  39
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer sequence

<400>  39
tagaaagtca accactccta cctgc                                             25


<210>  40
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2M protein (without signal peptide)

<400>  40

Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg His Pro Pro Glu 
1               5                   10                  15      


Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr Gln Phe His Pro 
            20                  25                  30          


Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys Lys Ile Pro Lys 
        35                  40                  45              


Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp Ser Phe Tyr Ile 
    50                  55                  60                  


Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp Thr Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Lys His Ala Ser Met Ala Glu Pro Lys Thr Val Tyr Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  41
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FcRn protein (without signal peptide)

<400>  41

Ser Glu Thr Arg Pro Pro Leu Met Tyr His Leu Thr Ala Val Ser Asn 
1               5                   10                  15      


Pro Ser Thr Gly Leu Pro Ser Phe Trp Ala Thr Gly Trp Leu Gly Pro 
            20                  25                  30          


Gln Gln Tyr Leu Thr Tyr Asn Ser Leu Arg Gln Glu Ala Asp Pro Cys 
        35                  40                  45              


Gly Ala Trp Met Trp Glu Asn Gln Val Ser Trp Tyr Trp Glu Lys Glu 
    50                  55                  60                  


Thr Thr Asp Leu Lys Ser Lys Glu Gln Leu Phe Leu Glu Ala Leu Lys 
65                  70                  75                  80  


Thr Leu Glu Lys Ile Leu Asn Gly Thr Tyr Thr Leu Gln Gly Leu Leu 
                85                  90                  95      


Gly Cys Glu Leu Ala Ser Asp Asn Ser Ser Val Pro Thr Ala Val Phe 
            100                 105                 110         


Ala Leu Asn Gly Glu Glu Phe Met Lys Phe Asn Pro Arg Ile Gly Asn 
        115                 120                 125             


Trp Thr Gly Glu Trp Pro Glu Thr Glu Ile Val Ala Asn Leu Trp Met 
    130                 135                 140                 


Lys Gln Pro Asp Ala Ala Arg Lys Glu Ser Glu Phe Leu Leu Asn Ser 
145                 150                 155                 160 


Cys Pro Glu Arg Leu Leu Gly His Leu Glu Arg Gly Arg Arg Asn Leu 
                165                 170                 175     


Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys Ala Arg Pro Gly Asn 
            180                 185                 190         


Ser Gly Ser Ser Val Leu Thr Cys Ala Ala Phe Ser Phe Tyr Pro Pro 
        195                 200                 205             


Glu Leu Lys Phe Arg Phe Leu Arg Asn Gly Leu Ala Ser Gly Ser Gly 
    210                 215                 220                 


Asn Cys Ser Thr Gly Pro Asn Gly Asp Gly Ser Phe His Ala Trp Ser 
225                 230                 235                 240 


Leu Leu Glu Val Lys Arg Gly Asp Glu His His Tyr Gln Cys Gln Val 
                245                 250                 255     


Glu His Glu Gly Leu Ala Gln Pro Leu Thr Val Asp Leu Asp Ser Ser 
            260                 265                 270         


Ala Arg Ser Ser Val Pro Val Val Gly Ile Val Leu Gly Leu Leu Leu 
        275                 280                 285             


Val Val Val Ala Ile Ala Gly Gly Val Leu Leu Trp Gly Arg Met Arg 
    290                 295                 300                 


Ser Gly Leu Pro Ala Pro Trp Leu Ser Leu Ser Gly Asp Asp Ser Gly 
305                 310                 315                 320 


Asp Leu Leu Pro Gly Gly Asn Leu Pro Pro Glu Ala Glu Pro Gln Gly 
                325                 330                 335     


Ala Asn Ala Phe Pro Ala Thr Ser 
            340                 


<210>  42
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FcRn signal peptide

<400>  42

Met Gly Met Pro Leu Pro Trp Ala Leu Ser Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Pro Gln Thr Trp Gly 
            20      


<210>  43
<211>  1288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FcRn mRNA (without signal peptide)

<400>  43
tcagagaccc gccccccact gatgtatcat ctcacggctg tgtcaaaccc atctacgggg       60

cttccctctt tctgggctac aggctggttg ggtcctcagc agtatctgac ctacaacagc      120

ctgcggcagg aagctgaccc ctgtggggcc tggatgtggg aaaatcaggt gtcttggtat      180

tgggagaagg agaccacaga cctcaaaagc aaagaacagc tcttcttgga ggccctcaag      240

accctggaga agatattaaa tgggacctac acactgcagg gcctgctggg ctgtgaactg      300

gcctcggata attcctcagt gcccacggct gtgtttgccc tcaatggtga ggagtttatg      360

aaattcaacc caagaatcgg caattggact ggggagtggc ctgagacgga aatcgttgct      420

aatctgtgga tgaagcagcc tgatgcggcc aggaaggaga gcgagttcct gctaaactct      480

tgtccggagc gactgctagg ccacctggag aggggccgac ggaacctgga gtggaaggag      540

ccgccgtcta tgcgcctgaa ggcccgtcct ggcaactctg gctcctccgt gctgacctgt      600

gctgctttct ccttctaccc accggagctc aagttccgat tcctgcgcaa tgggctagcc      660

tcaggctccg ggaattgcag cactggtccc aatggagatg gctctttcca cgcatggtca      720

ttgctggagg tcaaacgtgg agatgagcac cattatcaat gtcaagtgga gcatgagggg      780

ctggcacagc ctctcactgt ggacctagat tcatcagcca gatcttctgt gcctgtggtt      840

ggaatcgttc ttggtttatt gctggtggta gtggccatcg caggcggtgt gctgttgtgg      900

ggcaggatgc gcagcggtct gccagcccca tggctttctc tcagcggcga tgactctggt      960

gacctgttgc ctggtgggaa cttgccccca gaagctgaac ctcaaggtgc aaatgccttt     1020

ccagccactt cctgatgcag actcgggccc cctgcccact gcagcctttc gggctgtgtg     1080

acctcctgaa ctgtctccga gcctcctgag ggagcctggg cccgatgtcc tcccatggat     1140

ccctgctttt gtggcctgct tcagtttccc ttcttaatgt acatggttgt tttccatctc     1200

cacataaatt tggccccaaa tctgtgtgtg catcgttatt ctcaagtttc aagcagctgg     1260

aataaattga acgcgtctgg gaaagatc                                        1288


<210>  44
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FcRn signal peptide mRNA

<400>  44
aggagctagt gggtggagtt ggatgccctc agagttctcc agtcctaact gtgtacagac       60

aggatgtaag agaagaactg gaggctctaa gcagaggatc catcggctgc aggcagaggg      120

aagagggcct ctgtgaggaa caggctgagc gtcagaggag gaggcccagg cctggttctc      180

tagctctgta attaattaac taaagtggat caaatgagaa ggtgaaagtt cacagaggaa      240

cactcctgtc tgtcgtcttg gactgggtct ccatcccacc atccagcgtc ctggtctacg      300

aagagtccac agggaccttg tgaagaatca acaaggcggg gtccagagga gtcacgtgtc      360

ccttccactc cgggtcaccc tgtcggaatg gggatgccac tgccctgggc cctcagcctc      420

ttgttggtcc tcctgcctca gacctggggc                                       450


<210>  45
<211>  11197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  modified FcRn gene

<400>  45
gacagaggcc caaggggtgt gcttaggagc tagtgggtgg agttggatgc cctcagagtt       60

ctccagtcct aactgtgtac agacaggatg taagagaaga actggaggct ctaagcagag      120

gatccatcgg ctgcaggcag agggaagagg gcctctgtga ggaacaggct gagcgtcaga      180

ggaggaggcc caggcctggt tctctaggta tgagggacca gcaccccaag aggaaagagg      240

gttggggcct ggagctccag gtctgaggga ggagtgttat gacctgaggg ggagagagga      300

ggctggggtc tgaggaagga gagcaggacc ccgggcacct gagtctgagg gatgaagccg      360

gagcctaggg ttttgggttt gaggaaagat cttggaactg gactcctgga tctgagggag      420

gtggaactgg actcctggct tgggtttgag ggctcctgag gctgaaatct gagcccctgg      480

gaatgaggga ggaggagaag gcctggatcc tctggtctga gggaggagaa aaaggaaata      540

acagaagtct gagacaaatt ttggtctgtc tagctctgta attaattaac taaagtggat      600

caaatgagaa ggtgaaagtt cacagaggaa cactcctgtc tgtcgtcttg gactgggtct      660

ccatcccacc atccagcgtc ctggtctacg aagagtccac agggaccttg tgaagaatca      720

acaaggcggg gtccagagga gtcacgtgtc ccttccactc cgggtcaccc tgtcggaatg      780

gggatgccac tgccatgggc gctcagcctc ttgttggtcc tcctgcctca gacctggggc      840

atccagaaaa cccctcaaat tcaagtatac tcacgccacc caccggagaa tgggaagccg      900

aacatactga actgctacgt aacacagttc cacccgcctc acattgaaat ccaaatgctg      960

aagaacggga aaaaaattcc taaagtagag atgtcagata tgtccttcag caaggactgg     1020

tctttctata tcctggctca cactgaattc acccccactg agactgatac atatgcctgc     1080

agagttaagc atgccagtat ggccgagccc aagaccgtct actgggatcg agacatggga     1140

ggtggcggat ccggcggagg cggctcgggt ggcggcggct cttcaggtaa gaggccacca     1200

ggacctggag tgtgtcagga aggggacagg aagaagagcc aaagagtgga agagggacaa     1260

taagtccact ttttccatga tgtcctagcc ttcatggaaa tctcactgtg ggtaacttct     1320

ctgtgcatct gagtcaaata cacttgacaa tctcaggctc gtctctgtgt ccgtctgtcc     1380

gtcttgcttc ctttctgggt gtctgtcccc ttctctctgg aggatcatgg cacttcagat     1440

cgggtccagt tttcattctg cacctctgtg gggcacggtg cagtccgtga cccgagactc     1500

tcctgtttgc tctgcagaga cccgcccccc actgatgtat catctcacgg ctgtgtcaaa     1560

cccatctacg gggcttccct ctttctgggc tacaggctgg ttgggtcctc agcagtatct     1620

gacctacaac agcctgcggc aggaagctga cccctgtggg gcctggatgt gggaaaatca     1680

ggtgtcttgg tattgggaga aggagaccac agacctcaaa agcaaagaac agctcttctt     1740

ggaggccctc aagaccctgg agaagatatt aaatggtcag aagaggggtg agcttcagta     1800

ggctgggttt gaggaaggat aatgggtctg gattcctggg tcaaggaagg aggctggagc     1860

cctaggcctg aagtgggagg attaggtctg aaccctagga ataaggggga aggttgggat     1920

ctggacctca aggtccgagg gaggagaaga gaggaaggct ggcccttgct cctgagtctg     1980

cttgcctgcg tgttggcatc tagggaccta cacactgcag ggcctgctgg gctgtgaact     2040

ggcctcggat aattcctcag tgcccacggc tgtgtttgcc ctcaatggtg aggagtttat     2100

gaaattcaac ccaagaatcg gcaattggac tggggagtgg cctgagacgg aaatcgttgc     2160

taatctgtgg atgaagcagc ctgatgcggc caggaaggag agcgagttcc tgctaaactc     2220

ttgtccggag cgactgctag gccacctgga gaggggccga cggaacctgg agtggaaggg     2280

tgagcccatc tcctgtccct cctctagatc tccacagcca tgctcaaagc ccacccagca     2340

tcagtacaac ccctctcgcc tatcccagtg gatcttcttt aagataaggt ctcatgtagc     2400

ccaggctagc tctcacgtag ctcaagctag ccatgagctc atcgtgtagc tgaggatggt     2460

cttggattcc tgatcctctt agcccattcc aagtgctgat ttgacttaag tgtgttgcca     2520

cacccagcta attgttcttg tttgtgagac agggtctcag gctgactttg aactcagaga     2580

gatctcttga gtgctgggac aaaaggagtg tgctgctgta ccaggctgct ttttcttttt     2640

ctttttcttt ttttgttgtt gttatagtta gacagactct cccaatgtag accacgtgac     2700

ctcaaacttg tcatcctctt ggtctcagcc tcccaagtgc taggattttc catgtctttt     2760

tcttcttgtt aacgtctaag agttctttat atattgtgga cccaaatctt caccaaataa     2820

gtgtttcaaa cacactttcc ttgactgttt tcctttcatt cttttaaagt tatcttcaaa     2880

tctttttgtt ttgttttttc gagacagggt ttctctgtgt agccctggct gtcctggaac     2940

tcactttgta gaccaggctg gcttcgaact cagaaatccg cctgcctctg cctcctgagt     3000

gctgggatta aaggtgtgtg ccaccacgcc cggctttttt tttttttttt tttaagatta     3060

tttagttttg tatataagtg ttcggattgc atgtatgcct gctgcacacc agaagagggc     3120

atcagatccc atttcaggtg cttgtaagat gccatgtggt tgctgggact tgaacttagg     3180

acctctaaaa gagcagccag tgctcttgac tgctaagcca tctctccagt ccccagtcct     3240

cttttgaggg ctgtgttttt gttagtatat cttgcttgga ggtcatgccc agcccaggat     3300

gacctaggtc tctgtgtgta tttggaggag ttttatagct ttccattcta tgtatagatc     3360

ctcttgcttt tctgtctaac aaattgtatg tgaagaaggt ctgtcatttc tccatccaag     3420

tttcagcctg tctggatctg agttgtgtgt gtgctcatgt gggtggagac cagagcacag     3480

cctcgagtgt tgtatttatg acatcttttt ctgaaaaaca aatcttcagg ctggactcag     3540

ctcagtggtt gagagcacac agggatttta tatgtgcaca tgtatatttg tatgtgcacg     3600

tgagtgtcag aagagggcgt tccatcccct gtagctggag ttacagttag ttataacatg     3660

cccagtgtgg gtgctggaac tgaatttgag gcatctttaa gtagcagcaa gcccttagtc     3720

cctgagccac ctctccagcc ccagcccctg tgagattttt actctgtccc tctcacttag     3780

ttggctcagt ttgggattgc actcaggtcc tttctcttgc caagtaagag ctctgccact     3840

gagcaatctt taaggttggt ttttgatttt ggtttttggt ttttcgagac agggtttctc     3900

tgtgttggaa ctcaatctgt agaccaggct ggccttgacc tcaaagaccc atccatctct     3960

gcctcctaag ctctggagat cagaggcatg cgtcaccgcc gaccggctgg ccatgtttta     4020

ggttttaaaa cttaccttta cttatttatc tgtgatttag cgtgtgtgag tggtggtggt     4080

ggaggtggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt tcatatgtga     4140

tatatacctg tgctgtgtat ggggtgagca tctgtccaca tgctcagaag ccagagaagg     4200

tggctcctct gtctctttcc atcgtatgtt cttcacccag attctcttga tgagcctgaa     4260

gctacgcagg caaccagcca ggcccctact ggtcctcttt cctctgcccc tatcctcagc     4320

gccagggtta cagttatgaa gatatgttta agttttgaca taagtgctaa gaatttgaac     4380

ttgggtcctc atgcttgtgt aataaacact ttttcatgct gagccattcc cctaattatg     4440

gctaaatagt actccattct agaagcctgc atgctatctt cctttatctg ctgagggtgt     4500

ctacattgtt tctgtagttt ggctgttttt ttgtttgtta gagatttatt tatttattat     4560

atgtaagtat gctgtcttca gacactccag aagaaggcat cagatctcat tacggatggt     4620

tgtgagccac catgtggttg ctaggatttg aactcaggac ctttggaaaa gacgtcaatg     4680

ctcttaacca ctgagccatc tcttcagtcc tgtttggctg ttttgatgtt tctacaatgc     4740

aggatagtgg ccagtgtttc cctgaaattt tgttttgctt ttactatatt tactttattt     4800

ttttattttt ggttttttga gacagggttt ctctgaatag ctcaggctgt cctggaactc     4860

actctgtaga ccagtatggc cttgaactca gaaatctgtc tgcctctgcc tcccaagttc     4920

tgggattaaa ggcatgtgcc accactgccc atccctaaaa ttttgatacc aacttctgga     4980

taagtgtcca caaataggat agctaactcc attaaacaag aaaaaaaatt tttattatgt     5040

tttttgcttc catgtatgtc tgtgcaccat gtgcatgcag tactcacaga ggccagagga     5100

gggcgtcagg tcccctggtg ctggagttac agatggttag gagttgttca ccacatgggt     5160

gctctgactt gaacctgagt cctctggagg agctgccact cactacttga ctaattttac     5220

ccgctgagtc acttctctag ctctgagctc atttaccatg gaaaaccatg gtggcctgtg     5280

tggggataca tgtctttaat gctagcactc cggaggcagg gacaggtagt ctctgcacta     5340

cctgcactcc ccttgacaac cggtccaggt tccacgggta ctgactacag ttgctacatt     5400

gtgtctatgt gtgattttgt tcttcttaac aggcttctgg taccaggtgt taggttgtgt     5460

tactgtttcc ttccaaacat acaaacaagg caggggctct accactgagc cacgccccag     5520

cccttcactg gggaattcga ggctctaaca ttgagcatac cattgacgct catttgactt     5580

aaaatatttt taaggttaca cttattatta aggttactta cttgtgaatg agtgtgcata     5640

tgtgtgtgcg tgtgtgcgtg tgtgtgtgtg tgtgtgcgcg tgcgtgcgcg cgcgcgcgcg     5700

cgtgcgtgcg tgcgtgtgtg tgtgtgtgtg tgtgtgtgta gataggtcag agaacttggt     5760

gagttggatc tctccttttg ccatgtagat tctagggatg gaactcaggt catcaggctt     5820

gtccgcaggt gtctttacgt cacgtcacca gccctcttgt atttttctaa acctttttct     5880

gactatattt attttattgt taatttctgt ggatgtgtgt gtacatatat ggtgcaagtg     5940

accacagatg ccagaaggag gatcaggtcg tctgcagctg gagttagtta taggtggtta     6000

agtgtcgccc agttggtgct gagaattgag ctcagttctg tagagagaac agaaaacgct     6060

ctagcggcta agctgtgtct ctcgggcgct tcactggccc tcttttgact ttttcttttt     6120

tcttttttct tttctttttt tttttttttc tggagctgag gcccgaaccc agggccttgg     6180

gcttgctagg caagcactct accactgaac taaatcccca accccttgac tttttatttt     6240

gagacatggt ctcactaagt ttcccaagct aactcccagc tcaatctgtg gcttaactgg     6300

tgagcctgta gcacctctgc cttggccacc caggttacat ttctggggca aaggtgcttc     6360

cttttttttt tcttcttctt cttcttctgt taaacagaag ccaaggctgg gctgactctc     6420

cgaaccctca gggtcagaac tggaaaacag gagaaccgag ggtgtctctc agctacccac     6480

aggaagtcat cctcactgga aaacaatagc aagcacaagg caggacacag aagtgctgac     6540

tgaggtccgg tcctctgtgg cagagagccg gtgcctcagg tcttcctaga tgccagtgag     6600

gcccctcttt cggggaagct cgttagcttc ctcttcctaa gaagttgtca gcttattttc     6660

tgctgagaac cagagcagaa ccaagattgt gagacccacc ctagacagag ggaacgcctc     6720

tgccatgcac agcctttctg gggtctcaga tccccatgga cttcattttg tctaggggtt     6780

tattgctgtt gattcagggt cttgtgtagc ccaggctggc cccaaacttc ctatttcatc     6840

aaagtaacct tgaactcctg atcctctgac ctccagtctg gagtgctgag attacaggtg     6900

tacgccagca tgcatgacca atgtcagtgt gccggggatc aaacctagga acccaggact     6960

tcacaccgga aactgggcca catccccagc cataatatct ctctctctct ctctgtctct     7020

ctgtctctct gtctctctct ctctctgttt cttttttctg agacagggtt tctctgtata     7080

gccctggctg tcctggaact cactttgtag accaggctgg cctcgaactc agaaatccgc     7140

ctgcctctgc ctcccaagtg ctgggattaa aggcgtgcgc taccaccgcc cacttctttc     7200

tttctttctt tctttctttc tttctctctc tctctctctc tctctctctc tctctctctc     7260

tctctctctc tctctttctt cctttctttc tttccttggt ctcactatgt cactatgtag     7320

ccttggctag cctggaactg ctatgtagac caggttgccc tggtatccac agagatcaac     7380

ttgcctctgc tccctgaatg ctgggattca agatgtacta cacaccccac ccacaggtct     7440

cagtttttgc aagagcatcc aactcatttg gaactcatga ttttccggca acagttcctc     7500

aggtgctggg atcacttgtg tgggcatgca ccatcccacc cagctaggac agtcatgtct     7560

ctttgctcta tatatacact aatgtgttcc cagggccacg aataggtcac ggcactagag     7620

agatgtgcac taagtctccg tttagaaaca ggtagatgga ggagttgggg ctcagctggt     7680

agaaagcttg cttaaatggg ctccaccact ggcactgcat aaaccagtat ggcggcacac     7740

acctgctgtc tctcagcttt tagcaagtgg aagaaggaaa atcaggaatt caaagtcatc     7800

tgtatctata taataagttc aagactggtc tgggctgaga gtgaaacaaa caaatgtgcg     7860

cgagaagagg cgctgtgagc gccgagtttg ctgtgatgaa gacctgggtt ctggtcccca     7920

ggtccccttg caaaggctgg gcgtactgct gcgtgtctgt agctgcaggg atgggtctgg     7980

cagagacgga gcctcaccag ccactggcat ggctgaaagg gaggacccca ggttcatgga     8040

gaggctctgt ctcaaaaaat aagtgagccc ggcgtggtgg cgcacgcctt taatcccagc     8100

acttgggagg cagacacagg cagatttctg agttcgaggc cagcctggtc tacaaagtga     8160

gttcctggac agccagggct acacagagaa accctgtctc gaaaaaacaa acaaacaaac     8220

aaacaaaacc ccaaaaaaca acaacaaaaa aaagtggatg tggggagaga tggctcagtg     8280

gttaggaaca ctccctgttc ttgcagagga ccaggattta attcctagct cccatagggt     8340

aactcaccac catctgtaac tccatttcca ggggctctga tgtcctcatc tggcctccac     8400

agacactgca tgcatgtggt gcagagacac acatgctaaa aagcacccag acacacagag     8460

tgaaaaatat ataaagggga aaaaatgcaa agagcgaaag aggaaggagc ctgcaattga     8520

cctgtggcct tgacccatgc acatgccaca cacaccaaaa taagggggtg cagtggtggg     8580

gtcagcaggg tggggtgtct gtcactctgg gaagccctcc aagtcagcac agtgctgata     8640

cagggaagtg gagtctgtcc atggcaagct tcacccaagc cttggtgggg gtggggtggg     8700

tgggtgaggt catagcctag cctaactgct ggcccatccc attgcctgtg tccctgcaga     8760

gccgccgtct atgcgcctga aggcccgtcc tggcaactct ggctcctccg tgctgacctg     8820

tgctgctttc tccttctacc caccggagct caagttccga ttcctgcgca atgggctagc     8880

ctcaggctcc gggaattgca gcactggtcc caatggagat ggctctttcc acgcatggtc     8940

attgctggag gtcaaacgtg gagatgagca ccattatcaa tgtcaagtgg agcatgaggg     9000

gctggcacag cctctcactg tggacctagg tgaggctgcc cctccagcct cagtgtcttc     9060

tttgtttttt tttgtttttt taaaagatgt atttatttat ttcatgtatg tgagtacact     9120

gtcgctgtct tcagacacac cagaagagag catcagatcc tattacagac agttgtgagc     9180

caccatgtgg ttgctgggaa ttgaattcag gacctctaga agagcaggcg gtgctcttaa     9240

ccgctgagcc atctctctct ccagccccat tgtcttcttt gtttctgctc ctggcttctg     9300

attctccatt agctctgtgg ccagttcccc ctgagtctga ccatgatgag tcttgctgct     9360

actggtcttc atggtgtttg accattcact tttgcctctg acagttcttg ccatggcttt     9420

ggtaaagcac caactttgtt gactgtcctg tgactgctcc gccttcctct gttgggttct     9480

cacctagttc tgtcacagtg tggctgtgtc ctctcagtat aggtctcctc ctcctcttcc     9540

tcctcctcct attccttttc tttctcctcc tccttccatc cctcctcctc cctcctactt     9600

cctccccctc tccccttcct cctcctcctc tccctccttc tcctcctcct cctccttctt     9660

cagatttata tctaagtgta tccatatgta tttaattttc ccactttctt tgtgtgagag     9720

gggagagcag aggtgagtct gtgccatggg atacttgtgg cgacagagga caacttgtgg     9780

ttgtcagcct tggggctcaa acttaggtca ccgggcttta tggcaaaggc aatgccttca     9840

ctccttgaac ctctgacagc ctagatttat ggagggtcgg gctcaggtct cctggaattc     9900

gacacgagtt ctgggaacca aactctggtc ctccggaaga gctgcaagcc gtctctccag     9960

cacagtggct gactcttttt ttctcttttt tctttctttt tgtttttgtt tttgagacag    10020

ggtttctctg tagagctctg gctgtcctgg aactcacaat gtagaggagt ctggcctcta    10080

acccatagat ctgtgtgcct ctgcctccca agtgctggga ttaagaggtg tgtcaccact    10140

gtgtggccgg ttcttatatt cagtgaggaa acacatgagg cccagggcct tttctccgca    10200

tacacccacc ctcaaataca tgcttccggg ggtctccgag aaatcatcaa ctcctttctt    10260

ccctgtcttc atgatacttt ctggctgcag attcatcagc cagatcttct gtgcctgtgg    10320

ttggaatcgt tcttggttta ttgctggtgg tagtggccat cgcaggcggt gtgctgttgt    10380

ggggcaggat gcgcagcggt ctgccaggta tatgcaggat gggggagggg cggggccgtg    10440

tgcaggattg ggtgggagtg gccttgtgca ggatgaggga ggggcggggc cgtgtgcagg    10500

attggggtgg ggcgtggccg tgtgcagaat gagggagggg cgtggccgtg tgcaggattg    10560

gggaggggag ggaaggggcc gtgtgcagga ttggggaggg gcgtagctgt gtgcaggatt    10620

ggggaaggga ggggccgtgt gcaggattgg gggtcgtggc aggaagtagc gactcagaaa    10680

gaaagagggg aggcagagag ataatagaga caaaagagtc cctgaccacc ctgggaaaag    10740

agatgggaac agagaccata gcgtgaccct gtcaggtgtg ttgggtgggt gagaccttag    10800

atacttgtgc tgacctctgt tcctctctct cagccccatg gctttctctc agcggcgatg    10860

actctggtga cctgttgcct ggtgggaact tgcccccaga agctgaacct caaggtgcaa    10920

atgcctttcc agccacttcc tgatgcagac tcgggccccc tgcccactgc agcctttcgg    10980

gctgtgtgac ctcctgaact gtctccgagc ctcctgaggg agcctgggcc cgatgtcctc    11040

ccatggatcc ctgcttttgt ggcctgcttc agtttccctt cttaatgtac atggttgttt    11100

tccatctcca cataaatttg gccccaaatc tgtgtgtgca tcgttattct caagtttcaa    11160

gcagctggaa taaattgaac gcgtctggga aagatca                             11197


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker peptide

<400>  46

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker peptide

<400>  47

Gly Gly Gly Gly Ser 
1               5   


