                         SEQUENCE LISTING

<110>  Ϻҩҵ޹˾
 
<120>  һ򵰰׽øIdeEͻ

<130>  P20016418C

<150>  CN202010557830X
<151>  2020-06-18

<160>  35   

<170>  PatentIn version 3.5

<210>  1
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IdeEȫ

<400>  1

Met Lys Thr Ile Ala Tyr Pro Asn Lys Pro His Ser Leu Ser Ala Gly 
1               5                   10                  15      


Leu Leu Thr Ala Ile Ala Ile Phe Ser Leu Ala Ser Ser Asn Ile Thr 
            20                  25                  30          


Tyr Ala Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu 
        35                  40                  45              


Val Pro His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu 
    50                  55                  60                  


Thr Pro Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro 
65                  70                  75                  80  


Tyr Leu Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly 
                85                  90                  95      


Lys Asp Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His 
            100                 105                 110         


Trp Trp Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys 
        115                 120                 125             


His Pro Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp 
    130                 135                 140                 


Leu Lys Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu 
145                 150                 155                 160 


Phe Asn Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln 
                165                 170                 175     


Leu Gly Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr 
            180                 185                 190         


Tyr Leu Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr 
        195                 200                 205             


Gln Asp Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg 
    210                 215                 220                 


Gly Asp Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys 
225                 230                 235                 240 


Gly Leu Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly 
                245                 250                 255     


Arg Ala Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His 
            260                 265                 270         


Val Ile Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu 
        275                 280                 285             


Ala Ile Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys 
    290                 295                 300                 


Lys Tyr Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala 
305                 310                 315                 320 


Lys Lys Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe 
                325                 330                 335     


Thr Leu Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
            340                 345                 


<210>  2
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IdeE

<400>  2

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  3
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T8D

<400>  3

Asp Asp Tyr Gln Arg Asn Ala Asp Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  4
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T8E

<400>  4

Asp Asp Tyr Gln Arg Asn Ala Glu Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  5
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T8W

<400>  5

Asp Asp Tyr Gln Arg Asn Ala Trp Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  6
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T8Y

<400>  6

Asp Asp Tyr Gln Arg Asn Ala Tyr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  7
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A10K

<400>  7

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Lys Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  8
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A10R

<400>  8

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Arg Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  9
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T24A

<400>  9

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Ala Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  10
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T24G

<400>  10

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Gly Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  11
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T24S

<400>  11

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Ser Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  12
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59I

<400>  12

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ile Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  13
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59L

<400>  13

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Leu Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  14
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59V

<400>  14

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Val Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  15
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E97D

<400>  15

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Asp Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  16
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R280H

<400>  16

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His His His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  17
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R280K

<400>  17

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Lys His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


<210>  18
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT_del15

<400>  18

Pro His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr 
1               5                   10                  15      


Pro Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr 
            20                  25                  30          


Leu Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys 
        35                  40                  45              


Asp Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp 
    50                  55                  60                  


Trp Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His 
65                  70                  75                  80  


Pro Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu 
                85                  90                  95      


Lys Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe 
            100                 105                 110         


Asn Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu 
        115                 120                 125             


Gly Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr 
    130                 135                 140                 


Leu Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln 
145                 150                 155                 160 


Asp Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly 
                165                 170                 175     


Asp Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly 
            180                 185                 190         


Leu Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg 
        195                 200                 205             


Ala Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val 
    210                 215                 220                 


Ile Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala 
225                 230                 235                 240 


Ile Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys 
                245                 250                 255     


Tyr Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys 
            260                 265                 270         


Lys Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr 
        275                 280                 285             


Leu Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
    290                 295                 300 


<210>  19
<211>  299
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT_del16

<400>  19

His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
1               5                   10                  15      


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
            20                  25                  30          


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
        35                  40                  45              


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
    50                  55                  60                  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
65                  70                  75                  80  


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
                85                  90                  95      


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
            100                 105                 110         


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
        115                 120                 125             


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
    130                 135                 140                 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
145                 150                 155                 160 


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
                165                 170                 175     


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
            180                 185                 190         


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
        195                 200                 205             


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
    210                 215                 220                 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
225                 230                 235                 240 


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
                245                 250                 255     


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
            260                 265                 270         


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
        275                 280                 285             


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
    290                 295                 


<210>  20
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT_del17

<400>  20

Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu 
1               5                   10                  15      


Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala 
            20                  25                  30          


His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn 
        35                  40                  45              


Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe 
    50                  55                  60                  


Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu 
65                  70                  75                  80  


Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala 
                85                  90                  95      


Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr 
            100                 105                 110         


Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val 
        115                 120                 125             


Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn 
    130                 135                 140                 


Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys 
145                 150                 155                 160 


Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln 
                165                 170                 175     


Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn 
            180                 185                 190         


Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu 
        195                 200                 205             


Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn 
    210                 215                 220                 


Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr 
225                 230                 235                 240 


Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe 
                245                 250                 255     


Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys Ile 
            260                 265                 270         


Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser 
        275                 280                 285             


Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
    290                 295             


<210>  21
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT_del18

<400>  21

Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln 
1               5                   10                  15      


Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 
            20                  25                  30          


Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu 
        35                  40                  45              


Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 
    50                  55                  60                  


Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys 
65                  70                  75                  80  


Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 
                85                  90                  95      


Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 
            100                 105                 110         


Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 
        115                 120                 125             


Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 
    130                 135                 140                 


Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 
145                 150                 155                 160 


Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 
                165                 170                 175     


Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 
            180                 185                 190         


Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 
        195                 200                 205             


Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 
    210                 215                 220                 


Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 
225                 230                 235                 240 


Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 
                245                 250                 255     


Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys Ile Glu 
            260                 265                 270         


Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser 
        275                 280                 285             


Gly Lys Asp Ile Trp Gln Lys Leu Ser 
    290                 295         


<210>  22
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT_del19

<400>  22

Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln Phe 
1               5                   10                  15      


Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His Gln 
            20                  25                  30          


Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu Leu 
        35                  40                  45              


Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp Gln 
    50                  55                  60                  


Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys Gln 
65                  70                  75                  80  


Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala Ile 
                85                  90                  95      


Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe Arg 
            100                 105                 110         


Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met Pro 
        115                 120                 125             


Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val Phe 
    130                 135                 140                 


Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp Lys 
145                 150                 155                 160 


Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr Thr 
                165                 170                 175     


Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp Ile 
            180                 185                 190         


Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala Leu 
        195                 200                 205             


Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu Trp 
    210                 215                 220                 


Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val Thr 
225                 230                 235                 240 


Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val Gly 
                245                 250                 255     


Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys Ile Glu Gly 
            260                 265                 270         


Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser Gly 
        275                 280                 285             


Lys Asp Ile Trp Gln Lys Leu Ser 
    290                 295     



<210>  23
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT_delC5

<400>  23

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile 
305                 310 


<210>  24
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT_delC10

<400>  24

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Glu Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser 
305 


<210>  25
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T24A_del18

<400>  25

Ile Thr Ser Val Trp Ala Lys Gly Val Thr Pro Leu Thr Pro Glu Gln 
1               5                   10                  15      


Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 
            20                  25                  30          


Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu 
        35                  40                  45              


Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 
    50                  55                  60                  


Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys 
65                  70                  75                  80  


Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 
                85                  90                  95      


Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 
            100                 105                 110         


Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 
        115                 120                 125             


Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 
    130                 135                 140                 


Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 
145                 150                 155                 160 


Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 
                165                 170                 175     


Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 
            180                 185                 190         


Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 
        195                 200                 205             


Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 
    210                 215                 220                 


Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 
225                 230                 235                 240 


Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 
                245                 250                 255     


Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys Ile Glu 
            260                 265                 270         


Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser 
        275                 280                 285             


Gly Lys Asp Ile Trp Gln Lys Leu Ser 
    290                 295         


<210>  26
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59L_del18

<400>  26

Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln 
1               5                   10                  15      


Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 
            20                  25                  30          


Gln Gly Trp Tyr Asp Ile Thr Lys Leu Phe Asp Gly Lys Asp Asn Leu 
        35                  40                  45              


Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 
    50                  55                  60                  


Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys 
65                  70                  75                  80  


Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 
                85                  90                  95      


Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 
            100                 105                 110         


Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 
        115                 120                 125             


Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 
    130                 135                 140                 


Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 
145                 150                 155                 160 


Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 
                165                 170                 175     


Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 
            180                 185                 190         


Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 
        195                 200                 205             


Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 
    210                 215                 220                 


Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 
225                 230                 235                 240 


Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 
                245                 250                 255     


Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys Ile Glu 
            260                 265                 270         


Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser 
        275                 280                 285             


Gly Lys Asp Ile Trp Gln Lys Leu Ser 
    290                 295         


<210>  27
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59V_del18

<400>  27

Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln 
1               5                   10                  15      


Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 
            20                  25                  30          


Gln Gly Trp Tyr Asp Ile Thr Lys Val Phe Asp Gly Lys Asp Asn Leu 
        35                  40                  45              


Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 
    50                  55                  60                  


Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys 
65                  70                  75                  80  


Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 
                85                  90                  95      


Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 
            100                 105                 110         


Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 
        115                 120                 125             


Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 
    130                 135                 140                 


Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 
145                 150                 155                 160 


Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 
                165                 170                 175     


Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 
            180                 185                 190         


Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 
        195                 200                 205             


Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 
    210                 215                 220                 


Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 
225                 230                 235                 240 


Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 
                245                 250                 255     


Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys Ile Glu 
            260                 265                 270         


Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser 
        275                 280                 285             


Gly Lys Asp Ile Trp Gln Lys Leu Ser 
    290                 295         


<210>  28
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E97D_del18

<400>  28

Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln 
1               5                   10                  15      


Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 
            20                  25                  30          


Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu 
        35                  40                  45              


Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 
    50                  55                  60                  


Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Asp Lys 
65                  70                  75                  80  


Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 
                85                  90                  95      


Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 
            100                 105                 110         


Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 
        115                 120                 125             


Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 
    130                 135                 140                 


Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 
145                 150                 155                 160 


Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 
                165                 170                 175     


Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 
            180                 185                 190         


Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 
        195                 200                 205             


Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 
    210                 215                 220                 


Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 
225                 230                 235                 240 


Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 
                245                 250                 255     


Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys Ile Glu 
            260                 265                 270         


Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser 
        275                 280                 285             


Gly Lys Asp Ile Trp Gln Lys Leu Ser 
    290                 295         


<210>  29
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R280H_del18

<400>  29

Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln 
1               5                   10                  15      


Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 
            20                  25                  30          


Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu 
        35                  40                  45              


Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 
    50                  55                  60                  


Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys 
65                  70                  75                  80  


Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 
                85                  90                  95      


Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 
            100                 105                 110         


Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 
        115                 120                 125             


Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 
    130                 135                 140                 


Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 
145                 150                 155                 160 


Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 
                165                 170                 175     


Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 
            180                 185                 190         


Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 
        195                 200                 205             


Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 
    210                 215                 220                 


Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 
225                 230                 235                 240 


Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 
                245                 250                 255     


Gly Ile Asn Ala His His His Val Ala Ile Ser Ala Lys Lys Ile Glu 
            260                 265                 270         


Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser 
        275                 280                 285             


Gly Lys Asp Ile Trp Gln Lys Leu Ser 
    290                 295         


<210> 30
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E97D_del18_delC5

<400> 30

Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln 
1               5                   10                  15      


Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 
            20                  25                  30          


Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu 
        35                  40                  45              


Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 
    50                  55                  60                  


Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Asp Lys 
65                  70                  75                  80  


Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 
                85                  90                  95      


Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 
            100                 105                 110         


Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 
        115                 120                 125             


Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 
    130                 135                 140                 


Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 
145                 150                 155                 160 


Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 
                165                 170                 175     


Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 
            180                 185                 190         


Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 
        195                 200                 205             


Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 
    210                 215                 220                 


Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 
225                 230                 235                 240 


Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 
                245                 250                 255     


Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys Ile Glu 
            260                 265                 270         


Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser 
        275                 280                 285             


Gly Lys Asp Ile 
    290        


<210> 31
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E97D_del18_delC10

<400> 31

Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln 
1               5                   10                  15      


Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 
            20                  25                  30          


Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu 
        35                  40                  45              


Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 
    50                  55                  60                  


Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Asp Lys 
65                  70                  75                  80  


Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 
                85                  90                  95      


Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 
            100                 105                 110         


Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 
        115                 120                 125             


Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 
    130                 135                 140                 


Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 
145                 150                 155                 160 


Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 
                165                 170                 175     


Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 
            180                 185                 190         


Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 
        195                 200                 205             


Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 
    210                 215                 220                 


Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 
225                 230                 235                 240 


Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 
                245                 250                 255     


Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys Ile Glu 
            260                 265                 270         


Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser 
        275                 280                 285       


<210> 32
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59V_del18_delC5

<400> 32

Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln 
1               5                   10                  15      


Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 
            20                  25                  30          


Gln Gly Trp Tyr Asp Ile Thr Lys Val Phe Asp Gly Lys Asp Asn Leu 
        35                  40                  45              


Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 
    50                  55                  60                  


Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys 
65                  70                  75                  80  


Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 
                85                  90                  95      


Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 
            100                 105                 110         


Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 
        115                 120                 125             


Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 
    130                 135                 140                 


Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 
145                 150                 155                 160 


Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 
                165                 170                 175     


Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 
            180                 185                 190         


Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 
        195                 200                 205             


Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 
    210                 215                 220                 


Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 
225                 230                 235                 240 


Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 
                245                 250                 255     


Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys Ile Glu 
            260                 265                 270         


Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser 
        275                 280                 285             


Gly Lys Asp Ile 
    290         


<210> 33
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59L_del18_delC5

<400> 33

Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln 
1               5                   10                  15      


Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 
            20                  25                  30          


Gln Gly Trp Tyr Asp Ile Thr Lys Leu Phe Asp Gly Lys Asp Asn Leu 
        35                  40                  45              


Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 
    50                  55                  60                  


Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys 
65                  70                  75                  80  


Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 
                85                  90                  95      


Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 
            100                 105                 110         


Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 
        115                 120                 125             


Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 
    130                 135                 140                 


Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 
145                 150                 155                 160 


Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 
                165                 170                 175     


Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 
            180                 185                 190         


Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 
        195                 200                 205             


Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 
    210                 215                 220                 


Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 
225                 230                 235                 240 


Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 
                245                 250                 255     


Gly Ile Asn Ala His Arg His Val Ala Ile Ser Ala Lys Lys Ile Glu 
            260                 265                 270         


Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser 
        275                 280                 285             


Gly Lys Asp Ile 
    290         


<210> 34
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R280H_del18_delC5

<400> 34

Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro Glu Gln 
1               5                   10                  15      


Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu Ala His 
            20                  25                  30          


Gln Gly Trp Tyr Asp Ile Thr Lys Ala Phe Asp Gly Lys Asp Asn Leu 
        35                  40                  45              


Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp Phe Asp 
    50                  55                  60                  


Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro Glu Lys 
65                  70                  75                  80  


Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys Ala Ala 
                85                  90                  95      


Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn Tyr Phe 
            100                 105                 110         


Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly Val Met 
        115                 120                 125             


Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu Asn Val 
    130                 135                 140                 


Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp Lys Asp 
145                 150                 155                 160 


Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp Gln Thr 
                165                 170                 175     


Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu Asn Asp 
            180                 185                 190         


Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala Leu Ala 
        195                 200                 205             


Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile Asn Leu 
    210                 215                 220                 


Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile Tyr Val 
225                 230                 235                 240 


Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr Phe Val 
                245                 250                 255     


Gly Ile Asn Ala His His His Val Ala Ile Ser Ala Lys Lys Ile Glu 
            260                 265                 270         


Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu Ser Ser 
        275                 280                 285             


Gly Lys Asp Ile 
    290     


<210> 35
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A59V/E97D/R280H

<400> 35

Asp Asp Tyr Gln Arg Asn Ala Thr Glu Ala Tyr Ala Lys Glu Val Pro 
1               5                   10                  15      


His Gln Ile Thr Ser Val Trp Thr Lys Gly Val Thr Pro Leu Thr Pro 
            20                  25                  30          


Glu Gln Phe Arg Tyr Asn Asn Glu Asp Val Ile His Ala Pro Tyr Leu 
        35                  40                  45              


Ala His Gln Gly Trp Tyr Asp Ile Thr Lys Val Phe Asp Gly Lys Asp 
    50                  55                  60                  


Asn Leu Leu Cys Gly Ala Ala Thr Ala Gly Asn Met Leu His Trp Trp 
65                  70                  75                  80  


Phe Asp Gln Asn Lys Thr Glu Ile Glu Ala Tyr Leu Ser Lys His Pro 
                85                  90                  95      


Asp Lys Gln Lys Ile Ile Phe Asn Asn Gln Glu Leu Phe Asp Leu Lys 
            100                 105                 110         


Ala Ala Ile Asp Thr Lys Asp Ser Gln Thr Asn Ser Gln Leu Phe Asn 
        115                 120                 125             


Tyr Phe Arg Asp Lys Ala Phe Pro Asn Leu Ser Ala Arg Gln Leu Gly 
    130                 135                 140                 


Val Met Pro Asp Leu Val Leu Asp Met Phe Ile Asn Gly Tyr Tyr Leu 
145                 150                 155                 160 


Asn Val Phe Lys Thr Gln Ser Thr Asp Val Asn Arg Pro Tyr Gln Asp 
                165                 170                 175     


Lys Asp Lys Arg Gly Gly Ile Phe Asp Ala Val Phe Thr Arg Gly Asp 
            180                 185                 190         


Gln Thr Thr Leu Leu Thr Ala Arg His Asp Leu Lys Asn Lys Gly Leu 
        195                 200                 205             


Asn Asp Ile Ser Thr Ile Ile Lys Gln Glu Leu Thr Glu Gly Arg Ala 
    210                 215                 220                 


Leu Ala Leu Ser His Thr Tyr Ala Asn Val Ser Ile Ser His Val Ile 
225                 230                 235                 240 


Asn Leu Trp Gly Ala Asp Phe Asn Ala Glu Gly Asn Leu Glu Ala Ile 
                245                 250                 255     


Tyr Val Thr Asp Ser Asp Ala Asn Ala Ser Ile Gly Met Lys Lys Tyr 
            260                 265                 270         


Phe Val Gly Ile Asn Ala His His His Val Ala Ile Ser Ala Lys Lys 
        275                 280                 285             


Ile Glu Gly Glu Asn Ile Gly Ala Gln Val Leu Gly Leu Phe Thr Leu 
    290                 295                 300                 


Ser Ser Gly Lys Asp Ile Trp Gln Lys Leu Ser 
305                 310                 315 


