                               SEQUENCE LISTING

<110> SANGAMO THERAPEUTICS, INC.
 
<120> METHODS AND COMPOSITIONS FOR EXPRESSING PHENYLALANINE HYDROXYLASE

<130> 025297.WO018

<140>
<141>

<150> 63/037,857
<151> 2020-06-11

<160> 10    

<170> PatentIn version 3.5

<210> 1
<211> 130
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 1
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210> 2
<211> 321
<212> DNA
<213> Homo sapiens

<400> 2
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg g                                                321


<210> 3
<211> 393
<212> DNA
<213> Homo sapiens

<400> 3
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agt                                   393


<210> 4
<211> 133
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 4
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210> 5
<211> 1359
<212> DNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      PAH cDNA sequence"

<400> 5
atgtccactg cggtcctgga aaacccaggc ttgggcagga aactctctga ctttggacag       60

gaaacaagct atattgaaga caactgcaat caaaatggtg ccatatcact gatcttctca      120

ctcaaagaag aagttggtgc attggccaaa gtattgcgct tatttgagga gaatgatgta      180

aacctgaccc acattgaatc tagaccttct cgtttaaaga aagatgagta tgaatttttc      240

acccatttgg ataaacgtag cctgcctgct ctgacaaaca tcatcaagat cttgaggcat      300

gacattggtg ccactgtcca tgagctttca cgagataaga agaaagacac agtgccctgg      360

ttcccaagaa ccattcaaga gctggacaga tttgccaatc agattctcag ctatggagcg      420

gaactggatg ctgaccaccc tggttttaaa gatcctgtgt accgtgcaag acggaagcag      480

tttgctgaca ttgcctacaa ctaccgccat gggcagccca tccctcgagt ggaatacatg      540

gaggaagaaa agaaaacatg gggcacagtg ttcaagactc tgaagtcctt gtataaaacc      600

catgcttgct atgagtacaa tcacattttt ccacttcttg aaaagtactg tggcttccat      660

gaagataaca ttccccagct ggaagacgtt tctcagttcc tgcagacttg cactggtttc      720

cgcctccgac ctgtggctgg cctgctttcc tctcgggatt tcttgggtgg cctggccttc      780

cgagtcttcc actgcacaca gtacatcaga catggatcca agcccatgta tacccccgaa      840

cctgacatct gccatgagct gttgggacat gtgcccttgt tttcagatcg cagctttgcc      900

cagttttccc aggaaattgg ccttgcctct ctgggtgcac ctgatgaata cattgaaaag      960

ctcgccacaa tttactggtt tactgtggag tttgggctct gcaaacaagg agactccata     1020

aaggcatatg gtgctgggct cctgtcatcc tttggtgaat tacagtactg cttatcagag     1080

aagccaaagc ttctccccct ggagctggag aagacagcca tccaaaatta cactgtcacg     1140

gagttccagc ccctctatta cgtggcagag agttttaatg atgccaagga gaaagtaagg     1200

aactttgctg ccacaatacc tcggcccttc tcagttcgct acgacccata cacccaaagg     1260

attgaggtct tggacaatac ccagcagctt aagattttgg ctgattccat taacagtgaa     1320

attggaatcc tttgcagtgc cctccagaaa ataaagtaa                            1359


<210> 6
<211> 592
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 6
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgcc tg              592


<210> 7
<211> 225
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 7
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatgg                      225


<210> 8
<211> 108
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 8
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcag                   108


<210> 9
<211> 452
<212> PRT
<213> Homo sapiens

<400> 9
Met Ser Thr Ala Val Leu Glu Asn Pro Gly Leu Gly Arg Lys Leu Ser 
1               5                   10                  15      


Asp Phe Gly Gln Glu Thr Ser Tyr Ile Glu Asp Asn Cys Asn Gln Asn 
            20                  25                  30          


Gly Ala Ile Ser Leu Ile Phe Ser Leu Lys Glu Glu Val Gly Ala Leu 
        35                  40                  45              


Ala Lys Val Leu Arg Leu Phe Glu Glu Asn Asp Val Asn Leu Thr His 
    50                  55                  60                  


Ile Glu Ser Arg Pro Ser Arg Leu Lys Lys Asp Glu Tyr Glu Phe Phe 
65                  70                  75                  80  


Thr His Leu Asp Lys Arg Ser Leu Pro Ala Leu Thr Asn Ile Ile Lys 
                85                  90                  95      


Ile Leu Arg His Asp Ile Gly Ala Thr Val His Glu Leu Ser Arg Asp 
            100                 105                 110         


Lys Lys Lys Asp Thr Val Pro Trp Phe Pro Arg Thr Ile Gln Glu Leu 
        115                 120                 125             


Asp Arg Phe Ala Asn Gln Ile Leu Ser Tyr Gly Ala Glu Leu Asp Ala 
    130                 135                 140                 


Asp His Pro Gly Phe Lys Asp Pro Val Tyr Arg Ala Arg Arg Lys Gln 
145                 150                 155                 160 


Phe Ala Asp Ile Ala Tyr Asn Tyr Arg His Gly Gln Pro Ile Pro Arg 
                165                 170                 175     


Val Glu Tyr Met Glu Glu Glu Lys Lys Thr Trp Gly Thr Val Phe Lys 
            180                 185                 190         


Thr Leu Lys Ser Leu Tyr Lys Thr His Ala Cys Tyr Glu Tyr Asn His 
        195                 200                 205             


Ile Phe Pro Leu Leu Glu Lys Tyr Cys Gly Phe His Glu Asp Asn Ile 
    210                 215                 220                 


Pro Gln Leu Glu Asp Val Ser Gln Phe Leu Gln Thr Cys Thr Gly Phe 
225                 230                 235                 240 


Arg Leu Arg Pro Val Ala Gly Leu Leu Ser Ser Arg Asp Phe Leu Gly 
                245                 250                 255     


Gly Leu Ala Phe Arg Val Phe His Cys Thr Gln Tyr Ile Arg His Gly 
            260                 265                 270         


Ser Lys Pro Met Tyr Thr Pro Glu Pro Asp Ile Cys His Glu Leu Leu 
        275                 280                 285             


Gly His Val Pro Leu Phe Ser Asp Arg Ser Phe Ala Gln Phe Ser Gln 
    290                 295                 300                 


Glu Ile Gly Leu Ala Ser Leu Gly Ala Pro Asp Glu Tyr Ile Glu Lys 
305                 310                 315                 320 


Leu Ala Thr Ile Tyr Trp Phe Thr Val Glu Phe Gly Leu Cys Lys Gln 
                325                 330                 335     


Gly Asp Ser Ile Lys Ala Tyr Gly Ala Gly Leu Leu Ser Ser Phe Gly 
            340                 345                 350         


Glu Leu Gln Tyr Cys Leu Ser Glu Lys Pro Lys Leu Leu Pro Leu Glu 
        355                 360                 365             


Leu Glu Lys Thr Ala Ile Gln Asn Tyr Thr Val Thr Glu Phe Gln Pro 
    370                 375                 380                 


Leu Tyr Tyr Val Ala Glu Ser Phe Asn Asp Ala Lys Glu Lys Val Arg 
385                 390                 395                 400 


Asn Phe Ala Ala Thr Ile Pro Arg Pro Phe Ser Val Arg Tyr Asp Pro 
                405                 410                 415     


Tyr Thr Gln Arg Ile Glu Val Leu Asp Asn Thr Gln Gln Leu Lys Ile 
            420                 425                 430         


Leu Ala Asp Ser Ile Asn Ser Glu Ile Gly Ile Leu Cys Ser Ala Leu 
        435                 440                 445             


Gln Lys Ile Lys 
    450         


<210> 10
<211> 3390
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 10
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctagt aggctcagag gcacacagga gtttctgggc tcaccctgcc      180

cccttccaac ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc      240

acactgaaca aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa      300

acagcaaaca cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac      360

ctctctgggc ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg      420

agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg ggtacccggg gatcttgcta      480

ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta agtggtactc      540

tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac gctgtggttt      600

ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc      660

aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt      720

ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc      780

ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg      840

caccaccact gacctgggac agtcaggtaa gtatcaaggt tacaagacag gtttaaggag      900

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta      960

ttggtcttac tgacatccac tttgcctttc tctccacagg caattgatcc ccctgatctg     1020

cggcctcgac ggtatcgata agcttgccac catgtccact gcggtcctgg aaaacccagg     1080

cttgggcagg aaactctctg actttggaca ggaaacaagc tatattgaag acaactgcaa     1140

tcaaaatggt gccatatcac tgatcttctc actcaaagaa gaagttggtg cattggccaa     1200

agtattgcgc ttatttgagg agaatgatgt aaacctgacc cacattgaat ctagaccttc     1260

tcgtttaaag aaagatgagt atgaattttt cacccatttg gataaacgta gcctgcctgc     1320

tctgacaaac atcatcaaga tcttgaggca tgacattggt gccactgtcc atgagctttc     1380

acgagataag aagaaagaca cagtgccctg gttcccaaga accattcaag agctggacag     1440

atttgccaat cagattctca gctatggagc ggaactggat gctgaccacc ctggttttaa     1500

agatcctgtg taccgtgcaa gacggaagca gtttgctgac attgcctaca actaccgcca     1560

tgggcagccc atccctcgag tggaatacat ggaggaagaa aagaaaacat ggggcacagt     1620

gttcaagact ctgaagtcct tgtataaaac ccatgcttgc tatgagtaca atcacatttt     1680

tccacttctt gaaaagtact gtggcttcca tgaagataac attccccagc tggaagacgt     1740

ttctcagttc ctgcagactt gcactggttt ccgcctccga cctgtggctg gcctgctttc     1800

ctctcgggat ttcttgggtg gcctggcctt ccgagtcttc cactgcacac agtacatcag     1860

acatggatcc aagcccatgt atacccccga acctgacatc tgccatgagc tgttgggaca     1920

tgtgcccttg ttttcagatc gcagctttgc ccagttttcc caggaaattg gccttgcctc     1980

tctgggtgca cctgatgaat acattgaaaa gctcgccaca atttactggt ttactgtgga     2040

gtttgggctc tgcaaacaag gagactccat aaaggcatat ggtgctgggc tcctgtcatc     2100

ctttggtgaa ttacagtact gcttatcaga gaagccaaag cttctccccc tggagctgga     2160

gaagacagcc atccaaaatt acactgtcac ggagttccag cccctctatt acgtggcaga     2220

gagttttaat gatgccaagg agaaagtaag gaactttgct gccacaatac ctcggccctt     2280

ctcagttcgc tacgacccat acacccaaag gattgaggtc ttggacaata cccagcagct     2340

taagattttg gctgattcca ttaacagtga aattggaatc ctttgcagtg ccctccagaa     2400

aataaagtaa tctagaggat ctcgagagat ctaatcaacc tctggattac aaaatttgtg     2460

aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt     2520

taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata     2580

aatcctggtt gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg     2640

tgtgcactgt gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc     2700

tcctttccgg gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct     2760

gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt     2820

cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg     2880

ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc     2940

tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct     3000

ccctttgggc cgcctccccg cctgggatct ctgtgccttc tagttgccag ccatctgttg     3060

tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct     3120

aataaaatga ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg     3180

gggtggggca ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg     3240

cggtgggctc tatggaccgg tctcgagatc cactagggcc gcaggaaccc ctagtgatgg     3300

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgcccgg gctttgcccg     3360

ggcggcctca gtgagcgagc gagcgcgcag                                      3390


