                               SEQUENCE LISTING

<110> SHERLOCK BIOSCIENCES
 
<120> SARS-COV-2 DETECTION

<130> 2013065-0469

<140> PCT/US2021/036925
<141> 2021-06-11

<150> 63/185,268
<151> 2021-05-06

<150> 63/139,268
<151> 2021-01-19

<150> 63/068,817
<151> 2020-08-21

<150> 63/056,523
<151> 2020-07-24

<150> 63/054,214
<151> 2020-07-20

<150> 63/038,715
<151> 2020-06-12

<160> 760   

<170> PatentIn version 3.5

<210> 1
<211> 1225
<212> PRT
<213> Thermoclostridium caenicola

<400> 1
Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Asn 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Asp Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Glu Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Glu Asp 
    1055                 1060                 1065             


Val Arg  Asp Ile Phe Ser Glu  Gly Asn Ile Ile Arg  Asn Leu Val 
    1070                 1075                 1080             


Asp Thr  Leu Lys Gly Glu Asn  Met Asn Ala Phe Glu  Ser Val Tyr 
    1085                 1090                 1095             


Phe Pro  Glu Asn Lys Gly Ser  Lys Tyr Leu Gly Val  Arg Asn Asp 
    1100                 1105                 1110             


Val Ala  His Leu Asp Leu Met  Arg Lys Asn Gly Trp  Arg Leu Glu 
    1115                 1120                 1125             


Ala Gly  Lys Thr Cys Ser Val  Met Glu Asp Tyr Ile  Asn Arg Leu 
    1130                 1135                 1140             


Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr 
    1145                 1150                 1155             


Lys Thr  Leu Gln Gln Ile Phe  Asp Arg His Lys Val  Lys Ile Arg 
    1160                 1165                 1170             


Phe Thr  Val Glu Lys Gly Gly  Met Leu Lys Ile Glu  Asp Val Thr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Val His Leu  Lys Gly Ser Arg Leu  Ser Gly Ile 
    1190                 1195                 1200             


Glu Ile  Pro Ser His Gly Glu  Arg Phe Ile Asp Thr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Met  Val Tyr Pro Arg Gly  
    1220                 1225 


<210> 2
<211> 1217
<212> PRT
<213> Thalassospira profundimaris

<400> 2
Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser His Val Glu Gly Val Ala 
1               5                   10                  15      


Thr Glu Gln Pro Arg Arg Lys Leu Arg Leu Asn Thr Arg Pro Asp Ile 
            20                  25                  30          


Ser Arg Asp Ile Pro Gly Phe Ala Gln Ser His Asp Ala Leu Ile Ile 
        35                  40                  45              


Ala Gln Trp Ile Ser Ala Ile Asp Lys Ile Ala Thr Lys Pro Lys Pro 
    50                  55                  60                  


Asp Gln Lys Pro Thr Gln Arg Gln Met Asn Leu Arg Thr Thr Leu Gly 
65                  70                  75                  80  


Asp Ala Ala Trp Gln His Leu Met Ala Lys Asn Leu Leu Pro Ala Ala 
                85                  90                  95      


Lys Asp Pro Ala Ile Arg Glu Lys Leu His Leu Ile Trp Gln Ser Lys 
            100                 105                 110         


Ile Ala Pro Trp Gly Ala Ser Arg Pro Gln Glu Glu Lys Arg Gly Lys 
        115                 120                 125             


Pro Thr Pro Lys Gly Gly Trp Tyr Glu Arg Phe Cys Gly Ala Leu Ser 
    130                 135                 140                 


Pro Glu Ala Ile Thr Gln Asn Val Ala Arg Gln Ile Ala Lys Asp Ile 
145                 150                 155                 160 


Tyr Asp His Leu Tyr Val Ala Ala Lys Arg Lys Gly Arg Glu Pro Val 
                165                 170                 175     


Lys Gln Gly Glu Ser Ser Asn Lys Pro Gly Lys Phe Lys Pro Asp Arg 
            180                 185                 190         


Lys Leu Ser Leu Ile Glu Glu Arg Ala Glu Ser Ile Ala Lys Asn Ala 
        195                 200                 205             


Leu Arg Pro Gly Thr His Ala Pro Cys Pro Trp Gly Gln Asp Asp Gln 
    210                 215                 220                 


Ala Ile Tyr Glu Gln Ala Gly Asp Val Ala Thr Lys Ile Tyr Asp Asp 
225                 230                 235                 240 


Ala Arg Asp Tyr Leu Glu Asp Lys Lys Arg Arg Ser Gly Asn Arg Asn 
                245                 250                 255     


Thr Ser Ser Val Gln Tyr Leu Pro Arg Asp Leu Ala Val Lys Ile Leu 
            260                 265                 270         


Tyr Ala Gln Tyr Gly Arg Val Phe Gly Pro Asp Thr Thr Ile Lys Ala 
        275                 280                 285             


Ala Leu Asp Glu Gln Gln Ser Leu Phe Ala Leu His Thr Ala Ile Lys 
    290                 295                 300                 


Asp Cys Tyr His Arg Leu Val Asn Asp Ala Arg Lys Arg His Ile Leu 
305                 310                 315                 320 


Arg Ile Leu Pro Arg Asn Met Ala Ala Leu Phe Arg Leu Val Arg Ala 
                325                 330                 335     


Gln Tyr Asp Asn Arg Asp Ile Asn Ala Leu Ile Arg Leu Gly Lys Val 
            340                 345                 350         


Ile His Tyr His Ala Gly Glu Gln Gly Lys Asp Glu His His Gly Ile 
        355                 360                 365             


Arg Asp Tyr Trp Pro Ser Gln Gln Asp Ile Gln Asn Ser Arg Phe Trp 
    370                 375                 380                 


Gly Ser Asp Gly Gln Ala Asp Ile Lys Arg His Glu Ala Phe Ser Arg 
385                 390                 395                 400 


Ile Trp Arg His Ile Ile Ala Leu Ala Ser Arg Thr Leu His Asp Trp 
                405                 410                 415     


Ala Asp Pro Asp Ser Gln Lys Phe Thr Gly Asp Asp Asp Asp Ile Leu 
            420                 425                 430         


Met Arg Ala Gly Ala Ile Glu Ser Asn Val Trp Asp Ala Gly Arg Tyr 
        435                 440                 445             


Glu Arg Lys Cys Asp Val Leu Phe Gly Ala Gln Ala Ser Leu Phe Cys 
    450                 455                 460                 


Gly Ala Glu Asp Phe Glu Lys Ala Thr Leu Lys Gln Ala Ile Thr Gly 
465                 470                 475                 480 


Thr Gly Asn Leu Arg Asn Ala Thr Phe His Phe Lys Gly Lys Ala Arg 
                485                 490                 495     


Phe Glu Asn Glu Leu Gln Arg Leu Ala Asp Asp Val Pro Val Asp Val 
            500                 505                 510         


Gln Ser Ala Ile Ala Ala Leu Trp Gln Lys Asp Ala Glu Gly Arg Thr 
        515                 520                 525             


Arg Gln Ile Ala Glu Thr Leu Gln Ala Val Leu Ala Gly His Phe Leu 
    530                 535                 540                 


Ser Glu Arg Gln Asn Arg His Ile Leu Ala Thr Leu Met Ala Ala Met 
545                 550                 555                 560 


Ala Gln Pro Gly Asp Val Pro Leu Pro Arg Leu Arg Arg Val Leu Ala 
                565                 570                 575     


Arg His Asp Ser Ile Cys Gln Arg Gly Arg Ile Leu Pro Leu Pro Pro 
            580                 585                 590         


Cys Pro Asp Arg Ala Lys Leu Glu Glu Ser Pro Ala Leu Thr Cys Gln 
        595                 600                 605             


Tyr Thr Val Leu Lys Met Leu Tyr Asp Gly Pro Phe Arg Ala Trp Leu 
    610                 615                 620                 


Ala Gln Gln Asn Ser Thr Ile Leu Asn His Tyr Ile Asp Ser Thr Ile 
625                 630                 635                 640 


Ala Arg Thr Asn Lys Ala Ala Gln Asp Met Asn Gly Arg Lys Leu Ala 
                645                 650                 655     


Pro Ala Glu Lys Asp Leu Ile Thr Ala Arg Ala Ala Asp Ile Pro Arg 
            660                 665                 670         


Leu Ser Val Asp Glu Lys Met Val Asp Phe Leu Gly Arg Leu Thr Ala 
        675                 680                 685             


Ala Thr Ala Thr Glu Met Arg Val Gln Arg Gly Tyr Gln Ser Asp Gly 
    690                 695                 700                 


Glu Lys Ala Gln Lys Gln Ala Gly Tyr Ile Gly Glu Phe Glu Cys Asp 
705                 710                 715                 720 


Val Ile Ala Arg Ala Phe Ser Asp Phe Leu Gly Gln Ser Gly Phe Asp 
                725                 730                 735     


Phe Val Leu Lys Leu Lys Ala Asp Thr Pro Lys Pro Asp Ala Ala Gln 
            740                 745                 750         


Cys Asp Val Ala Ala Leu Ile Ala Pro Gly Asp Val Pro Ala Leu Thr 
        755                 760                 765             


Pro Gln Ala Trp Gln Gln Val Leu Tyr Phe Ile Leu His Leu Val Pro 
    770                 775                 780                 


Val Asp Asp Ala Ser Arg Leu Leu His Gln Thr Arg Lys Trp Gln Ala 
785                 790                 795                 800 


Leu Glu Lys Lys Gly Lys Asp Lys Glu Val Lys Lys Glu Lys Asp Lys 
                805                 810                 815     


Glu Val Lys Lys Glu Asp Glu Lys Pro Asp Ile Ala Asp Leu Gln Ser 
            820                 825                 830         


Val Leu Met Leu Tyr Leu Asp Met His Asp Ala Lys Phe Thr Gly Gly 
        835                 840                 845             


Ala Ala Leu His Gly Ile Glu Lys Phe Ala Glu Phe Phe Val Glu Lys 
    850                 855                 860                 


Ala Asp Phe Arg Ala Val Phe Pro Pro Gln Ser Leu Gln Asp Gln Asp 
865                 870                 875                 880 


Arg Ser Ile Pro Arg Arg Gly Leu Arg Glu Ile Val Arg Phe Gly His 
                885                 890                 895     


Leu Pro Leu Leu Gln His Met Ser Gly Thr Val Lys Ile Thr His Asp 
            900                 905                 910         


Asn Val Val Ala Trp Gln Thr Ala Arg Thr Pro Asp Ala Thr Gly Thr 
        915                 920                 925             


Ser Pro Ile Ala Arg Arg Gln Lys Gln Arg Glu Glu Leu His Ala Leu 
    930                 935                 940                 


Ala Val Glu Arg Pro Ala Arg Phe Arg Asn Ala Asp Leu His Asn Tyr 
945                 950                 955                 960 


Met His Ala Leu Val Asp Val Ile Lys His Arg Gln Leu Ser Ala Gln 
                965                 970                 975     


Val Thr Leu Ser Asp Gln Val Arg Leu His Arg Leu Met Met Gly Val 
            980                 985                 990         


Leu Gly Arg Leu Val Asp Tyr Ala  Gly Leu Trp Glu Arg  Asp Leu Tyr 
        995                 1000                 1005             


Phe Val  Leu Leu Ala Leu Leu  Tyr His His Gly Val  Thr Pro Asp 
    1010                 1015                 1020             


Asp Val  Leu Lys Gly Gln Gly  Lys Arg Lys Leu Ala  Asp Gly Gln 
    1025                 1030                 1035             


Val Val  Glu Ala Leu Lys Pro  Lys Asn Arg Lys Ala  Ala Ala Pro 
    1040                 1045                 1050             


Val Gly  Val Phe Asp Asp Leu  Asp His Tyr Gly Ile  Tyr Gln Asp 
    1055                 1060                 1065             


Asp Arg  Gln Ser Ile Arg Asn  Gly Leu Ser His Phe  Asn Met Leu 
    1070                 1075                 1080             


Arg Gly  Gly Thr Ala Pro Asp  Leu Ser His Trp Val  Asn Gln Thr 
    1085                 1090                 1095             


Arg Arg  Leu Val Ala His Asp  Arg Lys Leu Lys Asn  Ala Val Ala 
    1100                 1105                 1110             


Lys Ser  Val Ile Glu Met Leu  Ala Arg Glu Gly Phe  Asp Leu Asp 
    1115                 1120                 1125             


Trp Thr  Ile Glu Pro Asp Ser  Gly Lys His Ile Leu  Arg His Gly 
    1130                 1135                 1140             


Lys Ile  Arg Thr Arg Gln Ala  Gln His Phe Gln Lys  Ser Arg Ile 
    1145                 1150                 1155             


Arg Ile  Glu Lys Lys Ser Ala  Lys Pro Asp Lys Asn  Asp Thr Val 
    1160                 1165                 1170             


Lys Ile  Arg Glu Asn Leu His  Gly Asp Ala Met Val  Glu Arg Val 
    1175                 1180                 1185             


Ala Arg  Leu Phe Ala Ala Arg  Ala Gln Lys Tyr Arg  Asp Ile Thr 
    1190                 1195                 1200             


Thr Glu  Lys Arg Leu Asp His  Leu Phe Leu Lys Pro  Lys Gly 
    1205                 1210                 1215         


<210> 3
<211> 1129
<212> PRT
<213> Alicyclobacillus acidoterrestris

<400> 3
Met Ala Val Lys Ser Ile Lys Val Lys Leu Arg Leu Asp Asp Met Pro 
1               5                   10                  15      


Glu Ile Arg Ala Gly Leu Trp Lys Leu His Lys Glu Val Asn Ala Gly 
            20                  25                  30          


Val Arg Tyr Tyr Thr Glu Trp Leu Ser Leu Leu Arg Gln Glu Asn Leu 
        35                  40                  45              


Tyr Arg Arg Ser Pro Asn Gly Asp Gly Glu Gln Glu Cys Asp Lys Thr 
    50                  55                  60                  


Ala Glu Glu Cys Lys Ala Glu Leu Leu Glu Arg Leu Arg Ala Arg Gln 
65                  70                  75                  80  


Val Glu Asn Gly His Arg Gly Pro Ala Gly Ser Asp Asp Glu Leu Leu 
                85                  90                  95      


Gln Leu Ala Arg Gln Leu Tyr Glu Leu Leu Val Pro Gln Ala Ile Gly 
            100                 105                 110         


Ala Lys Gly Asp Ala Gln Gln Ile Ala Arg Lys Phe Leu Ser Pro Leu 
        115                 120                 125             


Ala Asp Lys Asp Ala Val Gly Gly Leu Gly Ile Ala Lys Ala Gly Asn 
    130                 135                 140                 


Lys Pro Arg Trp Val Arg Met Arg Glu Ala Gly Glu Pro Gly Trp Glu 
145                 150                 155                 160 


Glu Glu Lys Glu Lys Ala Glu Thr Arg Lys Ser Ala Asp Arg Thr Ala 
                165                 170                 175     


Asp Val Leu Arg Ala Leu Ala Asp Phe Gly Leu Lys Pro Leu Met Arg 
            180                 185                 190         


Val Tyr Thr Asp Ser Glu Met Ser Ser Val Glu Trp Lys Pro Leu Arg 
        195                 200                 205             


Lys Gly Gln Ala Val Arg Thr Trp Asp Arg Asp Met Phe Gln Gln Ala 
    210                 215                 220                 


Ile Glu Arg Met Met Ser Trp Glu Ser Trp Asn Gln Arg Val Gly Gln 
225                 230                 235                 240 


Glu Tyr Ala Lys Leu Val Glu Gln Lys Asn Arg Phe Glu Gln Lys Asn 
                245                 250                 255     


Phe Val Gly Gln Glu His Leu Val His Leu Val Asn Gln Leu Gln Gln 
            260                 265                 270         


Asp Met Lys Glu Ala Ser Pro Gly Leu Glu Ser Lys Glu Gln Thr Ala 
        275                 280                 285             


His Tyr Val Thr Gly Arg Ala Leu Arg Gly Ser Asp Lys Val Phe Glu 
    290                 295                 300                 


Lys Trp Gly Lys Leu Ala Pro Asp Ala Pro Phe Asp Leu Tyr Asp Ala 
305                 310                 315                 320 


Glu Ile Lys Asn Val Gln Arg Arg Asn Thr Arg Arg Phe Gly Ser His 
                325                 330                 335     


Asp Leu Phe Ala Lys Leu Ala Glu Pro Glu Tyr Gln Ala Leu Trp Arg 
            340                 345                 350         


Glu Asp Ala Ser Phe Leu Thr Arg Tyr Ala Val Tyr Asn Ser Ile Leu 
        355                 360                 365             


Arg Lys Leu Asn His Ala Lys Met Phe Ala Thr Phe Thr Leu Pro Asp 
    370                 375                 380                 


Ala Thr Ala His Pro Ile Trp Thr Arg Phe Asp Lys Leu Gly Gly Asn 
385                 390                 395                 400 


Leu His Gln Tyr Thr Phe Leu Phe Asn Glu Phe Gly Glu Arg Arg His 
                405                 410                 415     


Ala Ile Arg Phe His Lys Leu Leu Lys Val Glu Asn Gly Val Ala Arg 
            420                 425                 430         


Glu Val Asp Asp Val Thr Val Pro Ile Ser Met Ser Glu Gln Leu Asp 
        435                 440                 445             


Asn Leu Leu Pro Arg Asp Pro Asn Glu Pro Ile Ala Leu Tyr Phe Arg 
    450                 455                 460                 


Asp Tyr Gly Ala Glu Gln His Phe Thr Gly Glu Phe Gly Gly Ala Lys 
465                 470                 475                 480 


Ile Gln Cys Arg Arg Asp Gln Leu Ala His Met His Arg Arg Arg Gly 
                485                 490                 495     


Ala Arg Asp Val Tyr Leu Asn Val Ser Val Arg Val Gln Ser Gln Ser 
            500                 505                 510         


Glu Ala Arg Gly Glu Arg Arg Pro Pro Tyr Ala Ala Val Phe Arg Leu 
        515                 520                 525             


Val Gly Asp Asn His Arg Ala Phe Val His Phe Asp Lys Leu Ser Asp 
    530                 535                 540                 


Tyr Leu Ala Glu His Pro Asp Asp Gly Lys Leu Gly Ser Glu Gly Leu 
545                 550                 555                 560 


Leu Ser Gly Leu Arg Val Met Ser Val Asp Leu Gly Leu Arg Thr Ser 
                565                 570                 575     


Ala Ser Ile Ser Val Phe Arg Val Ala Arg Lys Asp Glu Leu Lys Pro 
            580                 585                 590         


Asn Ser Lys Gly Arg Val Pro Phe Phe Phe Pro Ile Lys Gly Asn Asp 
        595                 600                 605             


Asn Leu Val Ala Val His Glu Arg Ser Gln Leu Leu Lys Leu Pro Gly 
    610                 615                 620                 


Glu Thr Glu Ser Lys Asp Leu Arg Ala Ile Arg Glu Glu Arg Gln Arg 
625                 630                 635                 640 


Thr Leu Arg Gln Leu Arg Thr Gln Leu Ala Tyr Leu Arg Leu Leu Val 
                645                 650                 655     


Arg Cys Gly Ser Glu Asp Val Gly Arg Arg Glu Arg Ser Trp Ala Lys 
            660                 665                 670         


Leu Ile Glu Gln Pro Val Asp Ala Ala Asn His Met Thr Pro Asp Trp 
        675                 680                 685             


Arg Glu Ala Phe Glu Asn Glu Leu Gln Lys Leu Lys Ser Leu His Gly 
    690                 695                 700                 


Ile Cys Ser Asp Lys Glu Trp Met Asp Ala Val Tyr Glu Ser Val Arg 
705                 710                 715                 720 


Arg Val Trp Arg His Met Gly Lys Gln Val Arg Asp Trp Arg Lys Asp 
                725                 730                 735     


Val Arg Ser Gly Glu Arg Pro Lys Ile Arg Gly Tyr Ala Lys Asp Val 
            740                 745                 750         


Val Gly Gly Asn Ser Ile Glu Gln Ile Glu Tyr Leu Glu Arg Gln Tyr 
        755                 760                 765             


Lys Phe Leu Lys Ser Trp Ser Phe Phe Gly Lys Val Ser Gly Gln Val 
    770                 775                 780                 


Ile Arg Ala Glu Lys Gly Ser Arg Phe Ala Ile Thr Leu Arg Glu His 
785                 790                 795                 800 


Ile Asp His Ala Lys Glu Asp Arg Leu Lys Lys Leu Ala Asp Arg Ile 
                805                 810                 815     


Ile Met Glu Ala Leu Gly Tyr Val Tyr Ala Leu Asp Glu Arg Gly Lys 
            820                 825                 830         


Gly Lys Trp Val Ala Lys Tyr Pro Pro Cys Gln Leu Ile Leu Leu Glu 
        835                 840                 845             


Glu Leu Ser Glu Tyr Gln Phe Asn Asn Asp Arg Pro Pro Ser Glu Asn 
    850                 855                 860                 


Asn Gln Leu Met Gln Trp Ser His Arg Gly Val Phe Gln Glu Leu Ile 
865                 870                 875                 880 


Asn Gln Ala Gln Val His Asp Leu Leu Val Gly Thr Met Tyr Ala Ala 
                885                 890                 895     


Phe Ser Ser Arg Phe Asp Ala Arg Thr Gly Ala Pro Gly Ile Arg Cys 
            900                 905                 910         


Arg Arg Val Pro Ala Arg Cys Thr Gln Glu His Asn Pro Glu Pro Phe 
        915                 920                 925             


Pro Trp Trp Leu Asn Lys Phe Val Val Glu His Thr Leu Asp Ala Cys 
    930                 935                 940                 


Pro Leu Arg Ala Asp Asp Leu Ile Pro Thr Gly Glu Gly Glu Ile Phe 
945                 950                 955                 960 


Val Ser Pro Phe Ser Ala Glu Glu Gly Asp Phe His Gln Ile His Ala 
                965                 970                 975     


Asp Leu Asn Ala Ala Gln Asn Leu Gln Gln Arg Leu Trp Ser Asp Phe 
            980                 985                 990         


Asp Ile Ser Gln Ile Arg Leu Arg  Cys Asp Trp Gly Glu  Val Asp Gly 
        995                 1000                 1005             


Glu Leu  Val Leu Ile Pro Arg  Leu Thr Gly Lys Arg  Thr Ala Asp 
    1010                 1015                 1020             


Ser Tyr  Ser Asn Lys Val Phe  Tyr Thr Asn Thr Gly  Val Thr Tyr 
    1025                 1030                 1035             


Tyr Glu  Arg Glu Arg Gly Lys  Lys Arg Arg Lys Val  Phe Ala Gln 
    1040                 1045                 1050             


Glu Lys  Leu Ser Glu Glu Glu  Ala Glu Leu Leu Val  Glu Ala Asp 
    1055                 1060                 1065             


Glu Ala  Arg Glu Lys Ser Val  Val Leu Met Arg Asp  Pro Ser Gly 
    1070                 1075                 1080             


Ile Ile  Asn Arg Gly Asn Trp  Thr Arg Gln Lys Glu  Phe Trp Ser 
    1085                 1090                 1095             


Met Val  Asn Gln Arg Ile Glu  Gly Tyr Leu Val Lys  Gln Ile Arg 
    1100                 1105                 1110             


Ser Arg  Val Pro Leu Gln Asp  Ser Ala Cys Glu Asn  Thr Gly Asp 
    1115                 1120                 1125             


Ile 
    


<210> 4
<211> 1147
<212> PRT
<213> Alicyclobacillus kakegawensis

<400> 4
Met Ala Val Lys Ser Ile Lys Val Lys Leu Arg Leu Ser Glu Cys Pro 
1               5                   10                  15      


Asp Ile Leu Ala Gly Met Trp Gln Leu His Arg Ala Thr Asn Ala Gly 
            20                  25                  30          


Val Arg Tyr Tyr Thr Glu Trp Val Ser Leu Met Arg Gln Glu Ile Leu 
        35                  40                  45              


Tyr Ser Arg Gly Pro Asp Gly Gly Gln Gln Cys Tyr Met Thr Ala Glu 
    50                  55                  60                  


Asp Cys Gln Arg Glu Leu Leu Arg Arg Leu Arg Asn Arg Gln Leu His 
65                  70                  75                  80  


Asn Gly Arg Gln Asp Gln Pro Gly Thr Asp Ala Asp Leu Leu Ala Ile 
                85                  90                  95      


Ser Arg Arg Leu Tyr Glu Ile Leu Val Leu Gln Ser Ile Gly Lys Arg 
            100                 105                 110         


Gly Asp Ala Gln Gln Ile Ala Ser Ser Phe Leu Ser Pro Leu Val Asp 
        115                 120                 125             


Pro Asn Ser Lys Gly Gly Arg Gly Glu Ala Lys Ser Gly Arg Lys Pro 
    130                 135                 140                 


Ala Trp Gln Lys Met Arg Asp Gln Gly Asp Pro Arg Trp Val Ala Ala 
145                 150                 155                 160 


Arg Glu Lys Tyr Glu Gln Arg Lys Ala Val Asp Pro Ser Lys Glu Ile 
                165                 170                 175     


Leu Asn Ser Leu Asp Ala Leu Gly Leu Arg Pro Leu Phe Ala Val Phe 
            180                 185                 190         


Thr Glu Thr Tyr Arg Ser Gly Val Asp Trp Lys Pro Leu Gly Lys Ser 
        195                 200                 205             


Gln Gly Val Arg Thr Trp Asp Arg Asp Met Phe Gln Gln Ala Leu Glu 
    210                 215                 220                 


Arg Leu Met Ser Trp Glu Ser Trp Asn Arg Arg Val Gly Glu Glu Tyr 
225                 230                 235                 240 


Ala Arg Leu Phe Gln Gln Lys Met Lys Phe Glu Gln Glu His Phe Ala 
                245                 250                 255     


Glu Gln Ser His Leu Val Lys Leu Ala Arg Ala Leu Glu Ala Asp Met 
            260                 265                 270         


Arg Ala Ala Ser Gln Gly Phe Glu Ala Lys Arg Gly Thr Ala His Gln 
        275                 280                 285             


Ile Thr Arg Arg Ala Leu Arg Gly Ala Asp Arg Val Phe Glu Ile Trp 
    290                 295                 300                 


Lys Ser Ile Pro Glu Glu Ala Leu Phe Ser Gln Tyr Asp Glu Val Ile 
305                 310                 315                 320 


Arg Gln Val Gln Ala Glu Lys Arg Arg Asp Phe Gly Ser His Asp Leu 
                325                 330                 335     


Phe Ala Lys Leu Ala Glu Pro Lys Tyr Gln Pro Leu Trp Arg Ala Asp 
            340                 345                 350         


Glu Thr Phe Leu Thr Arg Tyr Ala Leu Tyr Asn Gly Val Leu Arg Asp 
        355                 360                 365             


Leu Glu Lys Ala Arg Gln Phe Ala Thr Phe Thr Leu Pro Asp Ala Cys 
    370                 375                 380                 


Val Asn Pro Ile Trp Thr Arg Phe Glu Ser Ser Gln Gly Ser Asn Leu 
385                 390                 395                 400 


His Lys Tyr Glu Phe Leu Phe Asp His Leu Gly Pro Gly Arg His Ala 
                405                 410                 415     


Val Arg Phe Gln Arg Leu Leu Val Val Glu Ser Glu Gly Ala Lys Glu 
            420                 425                 430         


Arg Asp Ser Val Val Val Pro Val Ala Pro Ser Gly Gln Leu Asp Lys 
        435                 440                 445             


Leu Val Leu Arg Glu Glu Glu Lys Ser Ser Val Ala Leu His Leu His 
    450                 455                 460                 


Asp Thr Ala Arg Pro Asp Gly Phe Met Ala Glu Trp Ala Gly Ala Lys 
465                 470                 475                 480 


Leu Gln Tyr Glu Arg Ser Thr Leu Ala Arg Lys Ala Arg Arg Asp Lys 
                485                 490                 495     


Gln Gly Met Arg Ser Trp Arg Arg Gln Pro Ser Met Leu Met Ser Ala 
            500                 505                 510         


Ala Gln Met Leu Glu Asp Ala Lys Gln Ala Gly Asp Val Tyr Leu Asn 
        515                 520                 525             


Ile Ser Val Arg Val Lys Ser Pro Ser Glu Val Arg Gly Gln Arg Arg 
    530                 535                 540                 


Pro Pro Tyr Ala Ala Leu Phe Arg Ile Asp Asp Lys Gln Arg Arg Val 
545                 550                 555                 560 


Thr Val Asn Tyr Asn Lys Leu Ser Ala Tyr Leu Glu Glu His Pro Asp 
                565                 570                 575     


Lys Gln Ile Pro Gly Ala Pro Gly Leu Leu Ser Gly Leu Arg Val Met 
            580                 585                 590         


Ser Val Asp Leu Gly Leu Arg Thr Ser Ala Ser Ile Ser Val Phe Arg 
        595                 600                 605             


Val Ala Lys Lys Glu Glu Val Glu Ala Leu Gly Asp Gly Arg Pro Pro 
    610                 615                 620                 


His Tyr Tyr Pro Ile His Gly Thr Asp Asp Leu Val Ala Val His Glu 
625                 630                 635                 640 


Arg Ser His Leu Ile Gln Met Pro Gly Glu Thr Glu Thr Lys Gln Leu 
                645                 650                 655     


Arg Lys Leu Arg Glu Glu Arg Gln Ala Val Leu Arg Pro Leu Phe Ala 
            660                 665                 670         


Gln Leu Ala Leu Leu Arg Leu Leu Val Arg Cys Gly Ala Ala Asp Glu 
        675                 680                 685             


Arg Ile Arg Thr Arg Ser Trp Gln Arg Leu Thr Lys Gln Gly Arg Glu 
    690                 695                 700                 


Phe Thr Lys Arg Leu Thr Pro Ser Trp Arg Glu Ala Leu Glu Leu Glu 
705                 710                 715                 720 


Leu Thr Arg Leu Glu Ala Tyr Cys Gly Arg Val Pro Asp Asp Glu Trp 
                725                 730                 735     


Ser Arg Ile Val Asp Arg Thr Val Ile Ala Leu Trp Arg Arg Met Gly 
            740                 745                 750         


Lys Gln Val Arg Asp Trp Arg Lys Gln Val Lys Ser Gly Ala Lys Val 
        755                 760                 765             


Lys Val Lys Gly Tyr Gln Leu Asp Val Val Gly Gly Asn Ser Leu Ala 
    770                 775                 780                 


Gln Ile Asp Tyr Leu Glu Gln Gln Tyr Lys Phe Leu Arg Arg Trp Ser 
785                 790                 795                 800 


Phe Phe Ala Arg Ala Ser Gly Leu Val Val Arg Ala Asp Arg Glu Ser 
                805                 810                 815     


His Phe Ala Val Ala Leu Arg Gln His Ile Glu Asn Ala Lys Arg Asp 
            820                 825                 830         


Arg Leu Lys Lys Leu Ala Asp Arg Ile Leu Met Glu Ala Leu Gly Tyr 
        835                 840                 845             


Val Tyr Glu Ala Ser Gly Pro Arg Glu Gly Gln Trp Thr Ala Gln His 
    850                 855                 860                 


Pro Pro Cys Gln Leu Ile Ile Leu Glu Glu Leu Ser Ala Tyr Arg Phe 
865                 870                 875                 880 


Ser Asp Asp Arg Pro Pro Ser Glu Asn Ser Lys Leu Met Ala Trp Gly 
                885                 890                 895     


His Arg Gly Ile Leu Glu Glu Leu Val Asn Gln Ala Gln Val His Asp 
            900                 905                 910         


Val Leu Val Gly Thr Val Tyr Ala Ala Phe Ser Ser Arg Phe Asp Ala 
        915                 920                 925             


Arg Thr Gly Ala Pro Gly Val Arg Cys Arg Arg Val Pro Ala Arg Phe 
    930                 935                 940                 


Val Gly Ala Thr Val Asp Asp Ser Leu Pro Leu Trp Leu Thr Glu Phe 
945                 950                 955                 960 


Leu Asp Lys His Arg Leu Asp Lys Asn Leu Leu Arg Pro Asp Asp Val 
                965                 970                 975     


Ile Pro Thr Gly Glu Gly Glu Phe Leu Val Ser Pro Cys Gly Glu Glu 
            980                 985                 990         


Ala Ala Arg Val Arg Gln Val His  Ala Asp Ile Asn Ala  Ala Gln Asn 
        995                 1000                 1005             


Leu Gln  Arg Arg Leu Trp Gln  Asn Phe Asp Ile Thr  Glu Leu Arg 
    1010                 1015                 1020             


Leu Arg  Cys Asp Val Lys Met  Gly Gly Glu Gly Thr  Val Leu Val 
    1025                 1030                 1035             


Pro Arg  Val Asn Asn Ala Arg  Ala Lys Gln Leu Phe  Gly Lys Lys 
    1040                 1045                 1050             


Val Leu  Val Ser Gln Asp Gly  Val Thr Phe Phe Glu  Arg Ser Gln 
    1055                 1060                 1065             


Thr Gly  Gly Lys Pro His Ser  Glu Lys Gln Thr Asp  Leu Thr Asp 
    1070                 1075                 1080             


Lys Glu  Leu Glu Leu Ile Ala  Glu Ala Asp Glu Ala  Arg Ala Lys 
    1085                 1090                 1095             


Ser Val  Val Leu Phe Arg Asp  Pro Ser Gly His Ile  Gly Lys Gly 
    1100                 1105                 1110             


His Trp  Ile Arg Gln Arg Glu  Phe Trp Ser Leu Val  Lys Gln Arg 
    1115                 1120                 1125             


Ile Glu  Ser His Thr Ala Glu  Arg Ile Arg Val Arg  Gly Val Gly 
    1130                 1135                 1140             


Ser Ser  Leu Asp 
    1145         


<210> 5
<211> 1108
<212> PRT
<213> Bacillus hisashii

<400> 5
Met Ala Thr Arg Ser Phe Ile Leu Lys Ile Glu Pro Asn Glu Glu Val 
1               5                   10                  15      


Lys Lys Gly Leu Trp Lys Thr His Glu Val Leu Asn His Gly Ile Ala 
            20                  25                  30          


Tyr Tyr Met Asn Ile Leu Lys Leu Ile Arg Gln Glu Ala Ile Tyr Glu 
        35                  40                  45              


His His Glu Gln Asp Pro Lys Asn Pro Lys Lys Val Ser Lys Ala Glu 
    50                  55                  60                  


Ile Gln Ala Glu Leu Trp Asp Phe Val Leu Lys Met Gln Lys Cys Asn 
65                  70                  75                  80  


Ser Phe Thr His Glu Val Asp Lys Asp Glu Val Phe Asn Ile Leu Arg 
                85                  90                  95      


Glu Leu Tyr Glu Glu Leu Val Pro Ser Ser Val Glu Lys Lys Gly Glu 
            100                 105                 110         


Ala Asn Gln Leu Ser Asn Lys Phe Leu Tyr Pro Leu Val Asp Pro Asn 
        115                 120                 125             


Ser Gln Ser Gly Lys Gly Thr Ala Ser Ser Gly Arg Lys Pro Arg Trp 
    130                 135                 140                 


Tyr Asn Leu Lys Ile Ala Gly Asp Pro Ser Trp Glu Glu Glu Lys Lys 
145                 150                 155                 160 


Lys Trp Glu Glu Asp Lys Lys Lys Asp Pro Leu Ala Lys Ile Leu Gly 
                165                 170                 175     


Lys Leu Ala Glu Tyr Gly Leu Ile Pro Leu Phe Ile Pro Tyr Thr Asp 
            180                 185                 190         


Ser Asn Glu Pro Ile Val Lys Glu Ile Lys Trp Met Glu Lys Ser Arg 
        195                 200                 205             


Asn Gln Ser Val Arg Arg Leu Asp Lys Asp Met Phe Ile Gln Ala Leu 
    210                 215                 220                 


Glu Arg Phe Leu Ser Trp Glu Ser Trp Asn Leu Lys Val Lys Glu Glu 
225                 230                 235                 240 


Tyr Glu Lys Val Glu Lys Glu Tyr Lys Thr Leu Glu Glu Arg Ile Lys 
                245                 250                 255     


Glu Asp Ile Gln Ala Leu Lys Ala Leu Glu Gln Tyr Glu Lys Glu Arg 
            260                 265                 270         


Gln Glu Gln Leu Leu Arg Asp Thr Leu Asn Thr Asn Glu Tyr Arg Leu 
        275                 280                 285             


Ser Lys Arg Gly Leu Arg Gly Trp Arg Glu Ile Ile Gln Lys Trp Leu 
    290                 295                 300                 


Lys Met Asp Glu Asn Glu Pro Ser Glu Lys Tyr Leu Glu Val Phe Lys 
305                 310                 315                 320 


Asp Tyr Gln Arg Lys His Pro Arg Glu Ala Gly Asp Tyr Ser Val Tyr 
                325                 330                 335     


Glu Phe Leu Ser Lys Lys Glu Asn His Phe Ile Trp Arg Asn His Pro 
            340                 345                 350         


Glu Tyr Pro Tyr Leu Tyr Ala Thr Phe Cys Glu Ile Asp Lys Lys Lys 
        355                 360                 365             


Lys Asp Ala Lys Gln Gln Ala Thr Phe Thr Leu Ala Asp Pro Ile Asn 
    370                 375                 380                 


His Pro Leu Trp Val Arg Phe Glu Glu Arg Ser Gly Ser Asn Leu Asn 
385                 390                 395                 400 


Lys Tyr Arg Ile Leu Thr Glu Gln Leu His Thr Glu Lys Leu Lys Lys 
                405                 410                 415     


Lys Leu Thr Val Gln Leu Asp Arg Leu Ile Tyr Pro Thr Glu Ser Gly 
            420                 425                 430         


Gly Trp Glu Glu Lys Gly Lys Val Asp Ile Val Leu Leu Pro Ser Arg 
        435                 440                 445             


Gln Phe Tyr Asn Gln Ile Phe Leu Asp Ile Glu Glu Lys Gly Lys His 
    450                 455                 460                 


Ala Phe Thr Tyr Lys Asp Glu Ser Ile Lys Phe Pro Leu Lys Gly Thr 
465                 470                 475                 480 


Leu Gly Gly Ala Arg Val Gln Phe Asp Arg Asp His Leu Arg Arg Tyr 
                485                 490                 495     


Pro His Lys Val Glu Ser Gly Asn Val Gly Arg Ile Tyr Phe Asn Met 
            500                 505                 510         


Thr Val Asn Ile Glu Pro Thr Glu Ser Pro Val Ser Lys Ser Leu Lys 
        515                 520                 525             


Ile His Arg Asp Asp Phe Pro Lys Val Val Asn Phe Lys Pro Lys Glu 
    530                 535                 540                 


Leu Thr Glu Trp Ile Lys Asp Ser Lys Gly Lys Lys Leu Lys Ser Gly 
545                 550                 555                 560 


Ile Glu Ser Leu Glu Ile Gly Leu Arg Val Met Ser Ile Asp Leu Gly 
                565                 570                 575     


Gln Arg Gln Ala Ala Ala Ala Ser Ile Phe Glu Val Val Asp Gln Lys 
            580                 585                 590         


Pro Asp Ile Glu Gly Lys Leu Phe Phe Pro Ile Lys Gly Thr Glu Leu 
        595                 600                 605             


Tyr Ala Val His Arg Ala Ser Phe Asn Ile Lys Leu Pro Gly Glu Thr 
    610                 615                 620                 


Leu Val Lys Ser Arg Glu Val Leu Arg Lys Ala Arg Glu Asp Asn Leu 
625                 630                 635                 640 


Lys Leu Met Asn Gln Lys Leu Asn Phe Leu Arg Asn Val Leu His Phe 
                645                 650                 655     


Gln Gln Phe Glu Asp Ile Thr Glu Arg Glu Lys Arg Val Thr Lys Trp 
            660                 665                 670         


Ile Ser Arg Gln Glu Asn Ser Asp Val Pro Leu Val Tyr Gln Asp Glu 
        675                 680                 685             


Leu Ile Gln Ile Arg Glu Leu Met Tyr Lys Pro Tyr Lys Asp Trp Val 
    690                 695                 700                 


Ala Phe Leu Lys Gln Leu His Lys Arg Leu Glu Val Glu Ile Gly Lys 
705                 710                 715                 720 


Glu Val Lys His Trp Arg Lys Ser Leu Ser Asp Gly Arg Lys Gly Leu 
                725                 730                 735     


Tyr Gly Ile Ser Leu Lys Asn Ile Asp Glu Ile Asp Arg Thr Arg Lys 
            740                 745                 750         


Phe Leu Leu Arg Trp Ser Leu Arg Pro Thr Glu Pro Gly Glu Val Arg 
        755                 760                 765             


Arg Leu Glu Pro Gly Gln Arg Phe Ala Ile Asp Gln Leu Asn His Leu 
    770                 775                 780                 


Asn Ala Leu Lys Glu Asp Arg Leu Lys Lys Met Ala Asn Thr Ile Ile 
785                 790                 795                 800 


Met His Ala Leu Gly Tyr Cys Tyr Asp Val Arg Lys Lys Lys Trp Gln 
                805                 810                 815     


Ala Lys Asn Pro Ala Cys Gln Ile Ile Leu Phe Glu Asp Leu Ser Asn 
            820                 825                 830         


Tyr Asn Pro Tyr Glu Glu Arg Ser Arg Phe Glu Asn Ser Lys Leu Met 
        835                 840                 845             


Lys Trp Ser Arg Arg Glu Ile Pro Arg Gln Val Ala Leu Gln Gly Glu 
    850                 855                 860                 


Ile Tyr Gly Leu Gln Val Gly Glu Val Gly Ala Gln Phe Ser Ser Arg 
865                 870                 875                 880 


Phe His Ala Lys Thr Gly Ser Pro Gly Ile Arg Cys Ser Val Val Thr 
                885                 890                 895     


Lys Glu Lys Leu Gln Asp Asn Arg Phe Phe Lys Asn Leu Gln Arg Glu 
            900                 905                 910         


Gly Arg Leu Thr Leu Asp Lys Ile Ala Val Leu Lys Glu Gly Asp Leu 
        915                 920                 925             


Tyr Pro Asp Lys Gly Gly Glu Lys Phe Ile Ser Leu Ser Lys Asp Arg 
    930                 935                 940                 


Lys Cys Val Thr Thr His Ala Asp Ile Asn Ala Ala Gln Asn Leu Gln 
945                 950                 955                 960 


Lys Arg Phe Trp Thr Arg Thr His Gly Phe Tyr Lys Val Tyr Cys Lys 
                965                 970                 975     


Ala Tyr Gln Val Asp Gly Gln Thr Val Tyr Ile Pro Glu Ser Lys Asp 
            980                 985                 990         


Gln Lys Gln Lys Ile Ile Glu Glu  Phe Gly Glu Gly Tyr  Phe Ile Leu 
        995                 1000                 1005             


Lys Asp  Gly Val Tyr Glu Trp  Val Asn Ala Gly Lys  Leu Lys Ile 
    1010                 1015                 1020             


Lys Lys  Gly Ser Ser Lys Gln  Ser Ser Ser Glu Leu  Val Asp Ser 
    1025                 1030                 1035             


Asp Ile  Leu Lys Asp Ser Phe  Asp Leu Ala Ser Glu  Leu Lys Gly 
    1040                 1045                 1050             


Glu Lys  Leu Met Leu Tyr Arg  Asp Pro Ser Gly Asn  Val Phe Pro 
    1055                 1060                 1065             


Ser Asp  Lys Trp Met Ala Ala  Gly Val Phe Phe Gly  Lys Leu Glu 
    1070                 1075                 1080             


Arg Ile  Leu Ile Ser Lys Leu  Thr Asn Gln Tyr Ser  Ile Ser Thr 
    1085                 1090                 1095             


Ile Glu  Asp Asp Ser Ser Lys  Gln Ser Met 
    1100                 1105             


<210> 6
<211> 1090
<212> PRT
<213> Laceyella sediminis

<400> 6
Met Ser Ile Arg Ser Phe Lys Leu Lys Ile Lys Thr Lys Ser Gly Val 
1               5                   10                  15      


Asn Ala Glu Glu Leu Arg Arg Gly Leu Trp Arg Thr His Gln Leu Ile 
            20                  25                  30          


Asn Asp Gly Ile Ala Tyr Tyr Met Asn Trp Leu Val Leu Leu Arg Gln 
        35                  40                  45              


Glu Asp Leu Phe Ile Arg Asn Glu Glu Thr Asn Glu Ile Glu Lys Arg 
    50                  55                  60                  


Ser Lys Glu Glu Ile Gln Gly Glu Leu Leu Glu Arg Val His Lys Gln 
65                  70                  75                  80  


Gln Gln Arg Asn Gln Trp Ser Gly Glu Val Asp Asp Gln Thr Leu Leu 
                85                  90                  95      


Gln Thr Leu Arg His Leu Tyr Glu Glu Ile Val Pro Ser Val Ile Gly 
            100                 105                 110         


Lys Ser Gly Asn Ala Ser Leu Lys Ala Arg Phe Phe Leu Gly Pro Leu 
        115                 120                 125             


Val Asp Pro Asn Asn Lys Thr Thr Lys Asp Val Ser Lys Ser Gly Pro 
    130                 135                 140                 


Thr Pro Lys Trp Lys Lys Met Lys Asp Ala Gly Asp Pro Asn Trp Val 
145                 150                 155                 160 


Gln Glu Tyr Glu Lys Tyr Met Ala Glu Arg Gln Thr Leu Val Arg Leu 
                165                 170                 175     


Glu Glu Met Gly Leu Ile Pro Leu Phe Pro Met Tyr Thr Asp Glu Val 
            180                 185                 190         


Gly Asp Ile His Trp Leu Pro Gln Ala Ser Gly Tyr Thr Arg Thr Trp 
        195                 200                 205             


Asp Arg Asp Met Phe Gln Gln Ala Ile Glu Arg Leu Leu Ser Trp Glu 
    210                 215                 220                 


Ser Trp Asn Arg Arg Val Arg Glu Arg Arg Ala Gln Phe Glu Lys Lys 
225                 230                 235                 240 


Thr His Asp Phe Ala Ser Arg Phe Ser Glu Ser Asp Val Gln Trp Met 
                245                 250                 255     


Asn Lys Leu Arg Glu Tyr Glu Ala Gln Gln Glu Lys Ser Leu Glu Glu 
            260                 265                 270         


Asn Ala Phe Ala Pro Asn Glu Pro Tyr Ala Leu Thr Lys Lys Ala Leu 
        275                 280                 285             


Arg Gly Trp Glu Arg Val Tyr His Ser Trp Met Arg Leu Asp Ser Ala 
    290                 295                 300                 


Ala Ser Glu Glu Ala Tyr Trp Gln Glu Val Ala Thr Cys Gln Thr Ala 
305                 310                 315                 320 


Met Arg Gly Glu Phe Gly Asp Pro Ala Ile Tyr Gln Phe Leu Ala Gln 
                325                 330                 335     


Lys Glu Asn His Asp Ile Trp Arg Gly Tyr Pro Glu Arg Val Ile Asp 
            340                 345                 350         


Phe Ala Glu Leu Asn His Leu Gln Arg Glu Leu Arg Arg Ala Lys Glu 
        355                 360                 365             


Asp Ala Thr Phe Thr Leu Pro Asp Ser Val Asp His Pro Leu Trp Val 
    370                 375                 380                 


Arg Tyr Glu Ala Pro Gly Gly Thr Asn Ile His Gly Tyr Asp Leu Val 
385                 390                 395                 400 


Gln Asp Thr Lys Arg Asn Leu Thr Leu Ile Leu Asp Lys Phe Ile Leu 
                405                 410                 415     


Pro Asp Glu Asn Gly Ser Trp His Glu Val Lys Lys Val Pro Phe Ser 
            420                 425                 430         


Leu Ala Lys Ser Lys Gln Phe His Arg Gln Val Trp Leu Gln Glu Glu 
        435                 440                 445             


Gln Lys Gln Lys Lys Arg Glu Val Val Phe Tyr Asp Tyr Ser Thr Asn 
    450                 455                 460                 


Leu Pro His Leu Gly Thr Leu Ala Gly Ala Lys Leu Gln Trp Asp Arg 
465                 470                 475                 480 


Asn Phe Leu Asn Lys Arg Thr Gln Gln Gln Ile Glu Glu Thr Gly Glu 
                485                 490                 495     


Ile Gly Lys Val Phe Phe Asn Ile Ser Val Asp Val Arg Pro Ala Val 
            500                 505                 510         


Glu Val Lys Asn Gly Arg Leu Gln Asn Gly Leu Gly Lys Ala Leu Thr 
        515                 520                 525             


Val Leu Thr His Pro Asp Gly Thr Lys Ile Val Thr Gly Trp Lys Ala 
    530                 535                 540                 


Glu Gln Leu Glu Lys Trp Val Gly Glu Ser Gly Arg Val Ser Ser Leu 
545                 550                 555                 560 


Gly Leu Asp Ser Leu Ser Glu Gly Leu Arg Val Met Ser Ile Asp Leu 
                565                 570                 575     


Gly Gln Arg Thr Ser Ala Thr Val Ser Val Phe Glu Ile Thr Lys Glu 
            580                 585                 590         


Ala Pro Asp Asn Pro Tyr Lys Phe Phe Tyr Gln Leu Glu Gly Thr Glu 
        595                 600                 605             


Leu Phe Ala Val His Gln Arg Ser Phe Leu Leu Ala Leu Pro Gly Glu 
    610                 615                 620                 


Asn Pro Pro Gln Lys Ile Lys Gln Met Arg Glu Ile Arg Trp Lys Glu 
625                 630                 635                 640 


Arg Asn Arg Ile Lys Gln Gln Val Asp Gln Leu Ser Ala Ile Leu Arg 
                645                 650                 655     


Leu His Lys Lys Val Asn Glu Asp Glu Arg Ile Gln Ala Ile Asp Lys 
            660                 665                 670         


Leu Leu Gln Lys Val Ala Ser Trp Gln Leu Asn Glu Glu Ile Ala Thr 
        675                 680                 685             


Ala Trp Asn Gln Ala Leu Ser Gln Leu Tyr Ser Lys Ala Lys Glu Asn 
    690                 695                 700                 


Asp Leu Gln Trp Asn Gln Ala Ile Lys Asn Ala His His Gln Leu Glu 
705                 710                 715                 720 


Pro Val Val Gly Lys Gln Ile Ser Leu Trp Arg Lys Asp Leu Ser Thr 
                725                 730                 735     


Gly Arg Gln Gly Ile Ala Gly Leu Ser Leu Trp Ser Ile Glu Glu Leu 
            740                 745                 750         


Glu Ala Thr Lys Lys Leu Leu Thr Arg Trp Ser Lys Arg Ser Arg Glu 
        755                 760                 765             


Pro Gly Val Val Lys Arg Ile Glu Arg Phe Glu Thr Phe Ala Lys Gln 
    770                 775                 780                 


Ile Gln His His Ile Asn Gln Val Lys Glu Asn Arg Leu Lys Gln Leu 
785                 790                 795                 800 


Ala Asn Leu Ile Val Met Thr Ala Leu Gly Tyr Lys Tyr Asp Gln Glu 
                805                 810                 815     


Gln Lys Lys Trp Ile Glu Val Tyr Pro Ala Cys Gln Val Val Leu Phe 
            820                 825                 830         


Glu Asn Leu Arg Ser Tyr Arg Phe Ser Tyr Glu Arg Ser Arg Arg Glu 
        835                 840                 845             


Asn Lys Lys Leu Met Glu Trp Ser His Arg Ser Ile Pro Lys Leu Val 
    850                 855                 860                 


Gln Met Gln Gly Glu Leu Phe Gly Leu Gln Val Ala Asp Val Tyr Ala 
865                 870                 875                 880 


Ala Tyr Ser Ser Arg Tyr His Gly Arg Thr Gly Ala Pro Gly Ile Arg 
                885                 890                 895     


Cys His Ala Leu Thr Glu Ala Asp Leu Arg Asn Glu Thr Asn Ile Ile 
            900                 905                 910         


His Glu Leu Ile Glu Ala Gly Phe Ile Lys Glu Glu His Arg Pro Tyr 
        915                 920                 925             


Leu Gln Gln Gly Asp Leu Val Pro Trp Ser Gly Gly Glu Leu Phe Ala 
    930                 935                 940                 


Thr Leu Gln Lys Pro Tyr Asp Asn Pro Arg Ile Leu Thr Leu His Ala 
945                 950                 955                 960 


Asp Ile Asn Ala Ala Gln Asn Ile Gln Lys Arg Phe Trp His Pro Ser 
                965                 970                 975     


Met Trp Phe Arg Val Asn Cys Glu Ser Val Met Glu Gly Glu Ile Val 
            980                 985                 990         


Thr Tyr Val Pro Lys Asn Lys Thr  Val His Lys Lys Gln  Gly Lys Thr 
        995                 1000                 1005             


Phe Arg  Phe Val Lys Val Glu  Gly Ser Asp Val Tyr  Glu Trp Ala 
    1010                 1015                 1020             


Lys Trp  Ser Lys Asn Arg Asn  Lys Asn Thr Phe Ser  Ser Ile Thr 
    1025                 1030                 1035             


Glu Arg  Lys Pro Pro Ser Ser  Met Ile Leu Phe Arg  Asp Pro Ser 
    1040                 1045                 1050             


Gly Thr  Phe Phe Lys Glu Gln  Glu Trp Val Glu Gln  Lys Thr Phe 
    1055                 1060                 1065             


Trp Gly  Lys Val Gln Ser Met  Ile Gln Ala Tyr Met  Lys Lys Thr 
    1070                 1075                 1080             


Ile Val  Gln Arg Met Glu Glu  
    1085                 1090 


<210> 7
<211> 1133
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 7
Met Phe Lys Lys Lys Leu Phe Asp Asp Glu Glu Phe Ile Ser Leu Ala 
1               5                   10                  15      


Gln Asn Gln Glu Glu Ser Asn Ala Leu Asn Ala Phe Lys Gly Phe Thr 
            20                  25                  30          


Thr His Phe Lys Asp Phe Gln Glu Asn Arg Lys Asn Met Tyr Ser Glu 
        35                  40                  45              


Asp Lys Glu Ser Thr Ala Ile Ala Tyr Arg Ile Ile His Glu Asn Leu 
    50                  55                  60                  


Pro Val Phe Ile Thr Asn Asn Ile Arg Phe Glu Lys Ile Ile Asn Glu 
65                  70                  75                  80  


Leu Asp Arg Ser Asn Ile His Ser Ile Glu Lys Glu Leu Lys Glu Glu 
                85                  90                  95      


Leu Ala Asn Asn Lys Leu Lys Asp Ile Phe Asn Ile Glu Tyr Phe Gln 
            100                 105                 110         


Asn Thr Leu Thr Gln Asn Asp Ile Thr Arg Tyr Asn Thr Ile Ile Gly 
        115                 120                 125             


Gly Lys Val Lys Ala Asp Gly Lys Lys Val Gln Gly Leu Asn Glu Tyr 
    130                 135                 140                 


Ile Asn Leu Phe Asn Gln His Asn Lys Asp Lys Lys Leu Pro Leu Leu 
145                 150                 155                 160 


Lys Pro Leu Tyr Lys Gln Ile Leu Ser Glu Glu Asn Ser Ala Ser Phe 
                165                 170                 175     


Ile Val Pro Ala Phe Glu Lys Asp Asn Glu Val Leu Gln Ser Ile Phe 
            180                 185                 190         


Asp Phe Trp Asn Lys Cys Ile Ile Asp Ala Lys Gly Pro Ile Ser Gly 
        195                 200                 205             


Lys Lys Tyr Asn Leu Leu Ser Lys Ile Gln Ser Leu Leu Gln Asn Leu 
    210                 215                 220                 


Asp Lys Leu Lys Asn Asn Gln Leu Glu Glu Met Tyr Phe Glu Asn Glu 
225                 230                 235                 240 


Asn Leu Ser Thr Ile Ser Asn Asp Val Tyr Gly Gln Trp Asn Leu Ile 
                245                 250                 255     


Arg Asp Ala Leu Gly Asn Phe Tyr Asn Ser Ile Asp Ala Lys Lys Asn 
            260                 265                 270         


Lys Lys Asp Tyr Tyr Ser Trp Lys Glu Ile Gln Asp Ala Leu Val Tyr 
        275                 280                 285             


Tyr Lys Gln Thr Asn Asp Glu Tyr Lys Asp Ile Asp Gln Lys Ala Phe 
    290                 295                 300                 


Leu Ile Tyr Phe Lys Glu Met Lys Val Asn Asp Gly Glu Glu Asn Thr 
305                 310                 315                 320 


Asn Asn Asn Ile Ile Asn Leu Ile Asn Glu Arg Tyr Lys Arg Ile Glu 
                325                 330                 335     


Pro Leu Leu Lys Glu Asp Arg Asp Asn Arg Lys Asp Leu His Gln Asp 
            340                 345                 350         


Lys Gly Lys Val Ala Ile Ile Lys Glu Phe Leu Asp Ser Leu Lys Leu 
        355                 360                 365             


Leu Gln Asn Thr Ile Lys Leu Leu Tyr Val Asp Asp Ser Leu Asp Asn 
    370                 375                 380                 


Met Asn Tyr Asp Phe Tyr Asn Gln Leu Thr Asp Tyr Tyr Glu Thr Leu 
385                 390                 395                 400 


Arg Pro Leu Asn Thr Leu Tyr Asn Arg Val Arg Asn Tyr Met Thr Arg 
                405                 410                 415     


Lys Pro Phe Ser Glu Glu Lys Phe Val Leu Thr Phe Asn Ser Pro Thr 
            420                 425                 430         


Leu Leu Asp Gly Trp Asp Leu Asn Lys Glu Glu Ala Asn Leu Gly Val 
        435                 440                 445             


Ile Leu Arg Lys Asp Asn Lys Tyr Tyr Leu Gly Ile Met Asn Lys Gly 
    450                 455                 460                 


Asp Asn Lys Ile Phe Lys Lys Tyr Asp Glu Glu Pro Gly Asp Asp Tyr 
465                 470                 475                 480 


Tyr Glu Lys Met Val Tyr Lys Leu Leu Pro Gly Pro Asn Arg Met Leu 
                485                 490                 495     


Arg Lys Val Phe Phe Ser Asn Lys Asn Ile Glu Tyr Tyr Lys Pro Asn 
            500                 505                 510         


Gln Asp Ile Gln Asn Leu Tyr Asn Lys Gly Glu Phe Lys Lys Gly Glu 
        515                 520                 525             


Ser Leu Asn Lys Glu Ser Leu His Lys Leu Ile Asp Phe Tyr Lys Asn 
    530                 535                 540                 


Ser Ile Ser Lys Asn Gly Asp Trp Ser Val Phe Asn Phe Lys Phe Lys 
545                 550                 555                 560 


Lys Thr Thr Ala Tyr Asp Asp Ile Ser Gln Phe Tyr Lys Asp Val Glu 
                565                 570                 575     


Asn Gln Gly Tyr Lys Leu Phe Phe Lys Thr Ile Lys Thr Ser Tyr Ile 
            580                 585                 590         


Asp Gln Leu Val Asn Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn 
        595                 600                 605             


Lys Asp Phe Ser Glu Asn Lys Lys Arg Lys Asp Glu Ser Asn Pro Asn 
    610                 615                 620                 


Leu His Thr Ile Tyr Phe Lys Asn Leu Phe Ser Glu Asp Asn Leu Lys 
625                 630                 635                 640 


Asn Val Val Tyr Lys Leu Asn Gly Lys Ala Glu Val Phe Tyr Arg Lys 
                645                 650                 655     


Lys Ser Ile Glu Tyr Pro Glu Glu Ile Arg Arg Lys Gly His His Tyr 
            660                 665                 670         


Asn Glu Leu Lys Asp Lys Phe Asp Tyr Pro Ile Ile Lys Asp Lys Arg 
        675                 680                 685             


Tyr Ser Glu Asp Lys Phe Leu Phe His Val Pro Ile Thr Leu Asn Phe 
    690                 695                 700                 


Leu Ala Lys Ser Asp Glu Lys Val Asn Glu Met Val Lys Asn Tyr Ile 
705                 710                 715                 720 


Ala Ala Thr Asn Glu Lys Ile His Ile Ile Gly Ile Asp Arg Gly Glu 
                725                 730                 735     


Arg Asn Leu Leu Tyr Leu Ser Leu Ile Asp Ser Asn Gly Asn Ile Val 
            740                 745                 750         


Lys Gln Gln Ser Leu Asn Ile Ile Glu Leu Pro Lys Tyr Gln Lys Gln 
        755                 760                 765             


Ile Asp Tyr His Ala Lys Leu Asn Glu Lys Glu Lys Gln Arg Leu Ala 
    770                 775                 780                 


Ala Arg Gln Asn Trp Asp Val Ile Glu Asn Ile Lys Glu Leu Lys Glu 
785                 790                 795                 800 


Gly Tyr Leu Ser Gln Val Ile His Gln Ile Ala Arg Leu Met Val Asp 
                805                 810                 815     


Tyr Lys Ala Ile Leu Val Met Glu Asp Leu Asn Phe Gly Phe Lys Arg 
            820                 825                 830         


Gly Arg Phe Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met 
        835                 840                 845             


Leu Ile Asp Lys Leu Ser Tyr Leu Val Phe Lys Glu Lys Asn Leu Cys 
    850                 855                 860                 


Glu Pro Gly Gly Ser Leu Arg Ala Tyr Gln Leu Ser Ala Pro Phe Lys 
865                 870                 875                 880 


Ser Phe Lys Ala Leu Gly Lys Gln Ser Gly Met Ile Phe Tyr Val Pro 
                885                 890                 895     


Ala Gln Tyr Thr Ser Lys Ile Asp Pro Thr Thr Gly Phe Tyr Asn Phe 
            900                 905                 910         


Leu Asn Ile Asp Val Ser Asn Leu Ala Arg Ser Lys Glu Thr Phe Ser 
        915                 920                 925             


Lys Phe Asp Lys Ile Val Tyr Asn Lys Lys Glu Asp Tyr Phe Glu Phe 
    930                 935                 940                 


Tyr Cys Lys Met Ile Asn Phe Glu Ser Ala Asn Gln Leu Thr Lys Lys 
945                 950                 955                 960 


Ser Gln Asn Lys Ala Asn Ala Glu Leu Lys Glu Phe Gln Trp Ile Leu 
                965                 970                 975     


Cys Ser Thr His His Asp Arg Phe Lys Val Glu Arg Lys Asn Asn Gln 
            980                 985                 990         


Ile Asn Tyr Cys Lys Ile Asn Val  Asn Glu Glu Leu Lys  Lys Leu Leu 
        995                 1000                 1005             


Asn Ser  Lys Gly Ile Asn Tyr  Glu Lys Ser Asn Asp  Leu Lys Ser 
    1010                 1015                 1020             


Glu Ile  Leu Asn Ile Asp Glu  Ser Lys Phe Phe Lys  Glu Leu Gly 
    1025                 1030                 1035             


Tyr Leu  Leu Lys Ile Leu Val  Ser Leu Arg Tyr Asn  Asn Gly Lys 
    1040                 1045                 1050             


Lys Gly  Ser Glu Glu Gln Asp  Phe Ile Leu Ser Pro  Val Lys Asn 
    1055                 1060                 1065             


Ala Ser  Gly Lys Phe Phe Cys  Thr Leu Asp Asn Asn  Asn Thr Leu 
    1070                 1075                 1080             


Pro Leu  Asp Ala Asp Ala Asn  Gly Ala Tyr Asn Ile  Ala Leu Lys 
    1085                 1090                 1095             


Gly Leu  Met Ile Val Gln Arg  Val Lys Ala Gly Gly  Lys Leu Asp 
    1100                 1105                 1110             


Leu Ser  Ile Ser Lys Asp Asp  Trp Ile Asn Phe Leu  Ile Met Asn 
    1115                 1120                 1125             


Lys Lys  Leu Pro Lys 
    1130             


<210> 8
<211> 1352
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 8
Met Ser Asn Gln Ser Val Phe Lys Asp Phe Thr Asn Leu Tyr Glu Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Arg 
            20                  25                  30          


Met Leu Glu Asp Ala Lys Val Phe Lys Thr Asp Glu Leu Ile Gln Lys 
        35                  40                  45              


Lys Tyr Glu Gln Thr Lys Pro Phe Ile Asn Lys Leu His Gln Glu Phe 
    50                  55                  60                  


Val Lys Glu Ser Leu Glu Gly Arg Ser Leu Glu Gly Leu Glu Ser Tyr 
65                  70                  75                  80  


Gln Asp Ile Leu Lys Glu Trp Gln Lys Asp Lys Lys Asp Lys Ile Ala 
                85                  90                  95      


Gln Lys Asn Leu Gly Ile Lys Glu Lys Glu Leu Tyr Lys Gln Val Thr 
            100                 105                 110         


Gln Leu Phe Asn Ala Lys Ala Lys Glu Trp Ser Glu Pro Tyr Ala His 
        115                 120                 125             


Leu Gly Leu Lys Lys Lys Asp Ile Gly Ile Leu Phe Glu Glu Gly Val 
    130                 135                 140                 


Phe Lys Ile Leu Lys Glu Lys Tyr Asn Asn Asp Lys Asp Ala Lys Ile 
145                 150                 155                 160 


Thr Asn Lys Val Thr Gly Glu Ile Phe Phe Glu Asp Phe Trp Lys Gly 
                165                 170                 175     


Phe Val Gly Tyr Phe Gln Lys Phe Phe Glu Thr Arg Lys Asn Phe Tyr 
            180                 185                 190         


Lys Asp Asp Gly Thr Ser Thr Ala Ile Ala Thr Arg Ile Val Ala Gln 
        195                 200                 205             


Asn Leu Lys Arg Phe Cys Asp Asn Ile Gly Leu Phe Glu Lys Ile Lys 
    210                 215                 220                 


Asp Gln Ile Asp Ser Ser Glu Val Glu Gln Ser Phe Gly Ile Ser Met 
225                 230                 235                 240 


Glu Lys Val Phe Ser Leu Asp Phe Tyr Asn Gln Cys Leu Leu Gln Gly 
                245                 250                 255     


Gly Ile Asp Lys Tyr Asn Glu Ile Leu Gly Gly Lys Thr Leu Glu Asn 
            260                 265                 270         


Gly Glu Lys Phe Lys Gly Ile Asn Glu Leu Ile Asn Lys Tyr Arg Gln 
        275                 280                 285             


Asp Asn Lys Gly Asp Lys Ser Ser Phe Leu Lys Ile Leu Asp Lys Gln 
    290                 295                 300                 


Ile Leu Ser Glu Lys Glu Ser Phe Ile Asp Glu Ile Lys Asn Asp Lys 
305                 310                 315                 320 


Glu Leu Glu Glu Thr Leu Lys Asn Leu His Glu Thr Ala Lys Val Lys 
                325                 330                 335     


Thr Lys Ile Phe Gly Thr Leu Phe Glu Asp Phe Ile Gly Asn Asn Thr 
            340                 345                 350         


Lys Tyr Asp Leu Ala Lys Ile Tyr Ile Ser Lys Glu Ala Phe Asn Thr 
        355                 360                 365             


Ile Ser His Lys Trp Thr Gly Gly Thr Asp Leu Phe Ala Glu Asn Leu 
    370                 375                 380                 


Phe Asn Ala Leu Lys Asp Glu Gln Ile Leu Lys Ser Ser Ala Lys Lys 
385                 390                 395                 400 


Lys Asp Gly Ser Tyr Val Phe Pro Asp Phe Ile Glu Phe Leu His Ile 
                405                 410                 415     


Lys Thr Ala Leu Glu Asn Val Pro Lys Asp Ile Asn Phe Trp Lys Glu 
            420                 425                 430         


Arg Tyr Tyr Val Asn Lys Glu Gly Glu Asn Lys Glu Phe Phe Leu Gly 
        435                 440                 445             


Asn Gly Glu Ile Trp Gln Gln Phe Leu Gln Ile Phe Asn Phe Glu Phe 
    450                 455                 460                 


Asn Glu Leu Phe Gln Lys Glu Ile Ile Asp Asn Gln Thr Gly Lys Lys 
465                 470                 475                 480 


Met His Ile Gly Tyr Lys Val Tyr Lys Glu Glu Ile Ser Lys Leu Leu 
                485                 490                 495     


Glu Asp Phe Lys Val Asp Lys Asp Ser Thr Val Ile Ile Lys His Phe 
            500                 505                 510         


Ala Asp Ser Val Leu Trp Ile Tyr Gln Met Ala Lys Tyr Phe Ala Leu 
        515                 520                 525             


Glu Lys Lys Arg Thr Trp Arg Asp Glu Tyr Asp Leu Asp Thr Phe Tyr 
    530                 535                 540                 


Thr Asp Pro Lys Asn Gly Tyr Leu Ala Phe Tyr Glu Asn Ala Tyr Glu 
545                 550                 555                 560 


Glu Ile Val Gln Ile Tyr Asn Lys Leu Arg Asn Tyr Leu Thr Lys Lys 
                565                 570                 575     


Pro Tyr Ser Thr Glu Lys Trp Lys Leu Asn Phe Gln Asn Ser Thr Leu 
            580                 585                 590         


Ala Ser Gly Trp Asp Lys Asn Lys Glu Ala Asp Asn Phe Thr Val Ile 
        595                 600                 605             


Leu Arg Lys Asp Gly Lys Tyr Phe Leu Gly Leu Met Arg Lys Gly Ala 
    610                 615                 620                 


Asn Lys Leu Phe Asp Lys Arg Tyr Gly Ser Glu Phe Ser Gln Gly Leu 
625                 630                 635                 640 


Glu Lys Gly Lys Tyr Glu Lys Met Asn Tyr Lys Tyr Phe Pro Ser Pro 
                645                 650                 655     


Ser Lys Met Ile Pro Lys Thr Ser Thr Gln Val His Glu Val Lys Lys 
            660                 665                 670         


His Phe Lys Asn Ser Ser Glu Pro Phe Phe Leu Glu Glu Ser Ser Ser 
        675                 680                 685             


Leu Gly Lys Phe Ile Lys Gln Leu Lys Ile Thr Lys Glu Val Phe Asp 
    690                 695                 700                 


Leu Asn Asn Phe Glu Tyr Lys Lys Ser Tyr Leu Ser Thr Leu Asn Gly 
705                 710                 715                 720 


Glu Ser Pro Asp Glu Ser Gln Arg Val Lys Ala Asp Ser Lys Lys Thr 
                725                 730                 735     


Gly Gln Val Lys Leu Phe Gln Lys Glu Phe Leu Asn Leu Ser Gln Asn 
            740                 745                 750         


Glu Leu Leu Tyr Lys Lys Ser Leu Phe Ala Trp Val Asp Phe Cys Lys 
        755                 760                 765             


Glu Tyr Leu Asp Cys Phe Pro Ser Thr Gly Asp Gly Phe Leu Gln Phe 
    770                 775                 780                 


Lys Lys Tyr Ile Gln Asp Thr Glu Lys Tyr Glu Ser Ile Asp Gln Phe 
785                 790                 795                 800 


Tyr Lys Asp Ile Glu Arg Gly Gly Tyr Lys Ile Ser Phe Gln Asn Ile 
                805                 810                 815     


Ser Glu Glu Tyr Ile Ser Cys Lys Asn Gln Asn Ser Glu Leu Tyr Leu 
            820                 825                 830         


Phe Lys Ile His Asn Lys Asp Trp Asn Leu Lys Asp Gly Lys Pro Lys 
        835                 840                 845             


Thr Gly Met Lys Asn Leu His Thr Met Tyr Phe Glu Ser Leu Phe Ser 
    850                 855                 860                 


Ser Glu Asn Ile Ala Gln Asn Phe Pro Met Lys Leu Asn Gly Gln Ala 
865                 870                 875                 880 


Glu Ile Phe Tyr Arg Pro Lys Thr Asp Ile Asn Lys Leu Glu Met Lys 
                885                 890                 895     


Lys Asp Ser Lys Gly Lys Asn Val Val Asp His Lys Arg Tyr Glu Glu 
            900                 905                 910         


Asp Lys Ile Phe Phe His Leu Pro Met Thr Leu Asn Arg Gly Lys Ser 
        915                 920                 925             


Leu Phe Asn Phe Asn Val Gln Leu Asn Asn Phe Leu Ala Asp Asn Pro 
    930                 935                 940                 


Glu Ile Asn Ile Ile Gly Val Asp Arg Gly Glu Lys His Leu Ala Tyr 
945                 950                 955                 960 


Tyr Ser Val Ile Asn Gln Asn Gln Glu Ile Leu Asp Gly Gly Thr Leu 
                965                 970                 975     


Asn Val Val Lys Gly Gly Asn Gly Lys Asp Ile Asp Tyr His Lys Lys 
            980                 985                 990         


Leu Glu Asp Lys Ala Glu Lys Arg  Glu Gln Ala Arg Lys  Asp Trp Gln 
        995                 1000                 1005             


Asp Val  Glu Gly Ile Lys Asp  Leu Lys Lys Gly Tyr  Ile Ser Gln 
    1010                 1015                 1020             


Val Val  Arg Lys Leu Ala Asp  Leu Ala Ile Glu His  Asn Ala Ile 
    1025                 1030                 1035             


Ile Val  Phe Glu Asp Leu Asn  Met Arg Phe Lys Gln  Ile Arg Gly 
    1040                 1045                 1050             


Gly Ile  Glu Lys Ser Val Tyr  Gln Gln Leu Glu Lys  Ala Leu Ile 
    1055                 1060                 1065             


Glu Lys  Leu Ser Phe Leu Val  Arg Lys Asn Glu Lys  Asn Pro Glu 
    1070                 1075                 1080             


Glu Ala  Gly Tyr Leu Leu Lys  Ala Tyr Gln Leu Ser  Ala Pro Phe 
    1085                 1090                 1095             


Glu Thr  Phe Gln Arg Ile Gly  Lys Gln Thr Gly Ile  Ile Phe Tyr 
    1100                 1105                 1110             


Thr Gln  Ala Ser Tyr Thr Ser  Lys Ile Asp Pro Leu  Thr Gly Trp 
    1115                 1120                 1125             


Arg Pro  Asn Leu Tyr Leu Lys  Tyr Ser Asn Ala Lys  Lys Ala Lys 
    1130                 1135                 1140             


Ala Asp  Ile Ser Lys Phe Ser  Glu Ile Glu Phe Ile  Asn Asn Arg 
    1145                 1150                 1155             


Phe Glu  Phe Thr Tyr Asp Leu  Gln Glu Phe Arg Ser  Gln Lys Asp 
    1160                 1165                 1170             


Lys Lys  Lys Glu Tyr Pro Lys  Lys Thr Leu Trp Thr  Leu Cys Ser 
    1175                 1180                 1185             


Ser Val  Glu Arg Tyr Arg Trp  Asn Arg Lys Leu Asn  Asp Asn Lys 
    1190                 1195                 1200             


Gly Gly  Tyr Glu His Tyr Ser  Asp Leu Thr Ser Asp  Phe Lys Lys 
    1205                 1210                 1215             


Leu Phe  Lys Lys Tyr Asn Ile  Asn Ile Asn Glu Asp  Ile Leu Gly 
    1220                 1225                 1230             


Gln Ile  Glu Asn Met Asp Thr  Asp Asp Arg Lys Asn  Asn Ala Arg 
    1235                 1240                 1245             


Phe Phe  Ser Gly Phe Met Phe  Phe Trp Asn Leu Ile  Cys Gln Ile 
    1250                 1255                 1260             


Arg Asn  Thr Asn Ser Asp Val  Ile Ser Gly Glu Ser  Asp Asn Asp 
    1265                 1270                 1275             


Phe Ile  Leu Ser Pro Val Glu  Pro Phe Phe Asp Ser  Arg Lys Ala 
    1280                 1285                 1290             


Ser Gln  Phe Gly Ser Asp Leu  Pro Glu Asn Gly Asp  Asp Asn Gly 
    1295                 1300                 1305             


Ala Phe  Asn Ile Ala Arg Lys  Gly Ile Met Ile Leu  Lys Lys Ile 
    1310                 1315                 1320             


Ser Gln  Tyr Val Glu Glu Asn  Glu Asn Cys Asp Lys  Leu Lys Trp 
    1325                 1330                 1335             


Gly Asp  Leu Tyr Ile Ser His  Thr Asp Trp Asp Asn  Phe Ile 
    1340                 1345                 1350         


<210> 9
<211> 921
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 9
Met Thr Asn Tyr Thr Asp Phe Ile Gly Leu Tyr Pro Val Gln Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Arg Pro Gln Gly Lys Thr Ala Glu Lys Met Arg 
            20                  25                  30          


Glu Ser Gly Leu Leu Glu Gln Asp Arg Glu Lys Ala Lys Asn Tyr Ile 
        35                  40                  45              


Val Met Lys Ala Leu Ile Asp Asp Tyr His Arg Arg Phe Ile Asn Glu 
    50                  55                  60                  


Leu Leu Glu Lys Ala Ser Phe Asp Trp Gln Pro Leu Phe Glu Ala Leu 
65                  70                  75                  80  


Asn Asn Val Lys Val Asn Lys Asp Asp Lys Ser Lys Lys Glu Leu Glu 
                85                  90                  95      


Lys Glu Gln Leu His Met Arg Lys Glu Leu Ile Gly Leu Phe Glu Lys 
            100                 105                 110         


Asp Glu Arg Phe Lys Tyr Leu Phe Ser Glu Lys Leu Phe Ser Glu Leu 
        115                 120                 125             


Leu Asn Lys Glu Ile Ser Glu Arg Asn Asp Pro Asp Glu Met Glu Ala 
    130                 135                 140                 


Met Arg Ser Phe Asp Arg Phe Ser Gly Tyr Phe Ile Gly Phe His Glu 
145                 150                 155                 160 


Asn Arg Arg Asn Ile Tyr Ser Asn Glu Asp Lys His Asn Ser Leu Ala 
                165                 170                 175     


Tyr Arg Val Val Ala Glu Asn Phe Pro Lys Phe Ala Asp Asn Cys Arg 
            180                 185                 190         


Lys Tyr Ser Leu Ile Lys Glu Asn Met Gln Glu Ala Val Val Glu Phe 
        195                 200                 205             


Lys Lys Glu Ile Ala Ser Val Val Asp Ile Asp Val Asp Gln Met Phe 
    210                 215                 220                 


Asp Ile Ser Tyr Phe Asn Lys Val Leu Thr Gln Lys Gly Ile Asp Asp 
225                 230                 235                 240 


Tyr Asn Thr Met Leu Gly Gly Val Ser Glu Glu Gly Ser Val Lys Ile 
                245                 250                 255     


Arg Gly Leu Asn Glu Phe Leu Asn Leu Tyr Tyr Gln Lys Val Thr Asp 
            260                 265                 270         


Asn Lys Arg Ile Lys Met Ala Pro Leu Tyr Lys Gln Ile Leu Cys Glu 
        275                 280                 285             


Ser Lys Thr Lys Ser Phe Ile Pro Tyr Met Phe Glu Asn Asp Glu Glu 
    290                 295                 300                 


Val Ile Ser Ser Ile Asn Gln Tyr Tyr Asp Ser Val Lys Tyr Asp Ile 
305                 310                 315                 320 


Leu Gln Arg Ser Val Tyr Leu Leu Ser Asn Tyr Lys Glu Tyr Asp Ala 
                325                 330                 335     


Ser Lys Ile Phe Ile Asp Gln Lys Ser Ile Ser Ser Ile Ser Ile Val 
            340                 345                 350         


Leu Phe Gly Ser Trp Glu Thr Leu Gly Gly Leu Met Gln Ile Tyr Lys 
        355                 360                 365             


Ala Asp Gln Ile Gly Asp Pro Gly Leu Glu Lys Thr Arg Lys Lys Val 
    370                 375                 380                 


Asp Lys Trp Leu Ser Ser Ser Tyr Phe Thr Leu Lys Glu Val Phe Glu 
385                 390                 395                 400 


Ala Ile Gly Glu Gln Asp Pro Phe Arg Val Tyr Val Glu Lys Leu Ser 
                405                 410                 415     


Leu Val Leu Lys Asn Ile Glu Glu Phe Asp Lys Ser Cys Leu Leu Glu 
            420                 425                 430         


Gly Thr His Phe Ser Gly Asp Glu Leu Leu Thr Gln Asp Ile Lys Gly 
        435                 440                 445             


Phe Leu Asp Leu Leu Met Glu Val Gln His Leu Met Lys Pro Phe Asn 
    450                 455                 460                 


Ala Lys Glu Asp Leu Asp Lys Asp Ala Ala Phe Tyr Ser Glu Tyr Asn 
465                 470                 475                 480 


Glu Ile Tyr Glu Ala Leu Ser Glu Ile Ile Pro Leu Tyr Asn Lys Val 
                485                 490                 495     


Arg Asn Tyr Ala Thr Lys Lys Lys Tyr Ser Thr Tyr Lys Ile Lys Met 
            500                 505                 510         


Asn Phe Gly Asn Pro Thr Leu Ala Ala Gly Trp Asp Leu Asn Lys Glu 
        515                 520                 525             


Arg Asp Asn Thr Ala Val Ile Leu Leu Arg Gly Asn Asn Tyr Tyr Leu 
    530                 535                 540                 


Gly Ile Met Asn Pro Lys Lys Lys Thr Lys Phe Glu Glu Leu Pro Ser 
545                 550                 555                 560 


Gly Glu Asp Asn Asp Cys Tyr Arg Lys Met Val Tyr Lys Leu Leu Pro 
                565                 570                 575     


Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Gly Ile 
            580                 585                 590         


Gly Thr Phe Asn Pro Ser Lys Glu Ile Leu Glu Gly Tyr Glu Thr Gly 
        595                 600                 605             


Lys His Lys Leu Gly Asp Ser Phe Asp Ile Asp Tyr Cys His Ser Leu 
    610                 615                 620                 


Ile Asp Phe Phe Lys Glu Asn Ile Pro Lys Tyr Gly Asp Trp Gly Thr 
625                 630                 635                 640 


Tyr Glu Phe Lys Phe Ser Pro Thr Glu Glu Tyr Ser Asp Ile Ser Gln 
                645                 650                 655     


Phe Tyr Lys Glu Val Ser Glu Gln Gly Tyr Lys Ile Thr Phe Gln Asn 
            660                 665                 670         


Ile Ser Arg Lys Ala Ile Asp Asp Leu Val Asn Asn Gly Ala Leu Phe 
        675                 680                 685             


Leu Tyr Gln Ile Tyr Asn Lys Asp Phe Ser Glu His Ser Lys Gly Lys 
    690                 695                 700                 


Asn Asn Leu His Thr Met Tyr Trp Lys Ala Ala Phe Ser Glu Glu Asn 
705                 710                 715                 720 


Leu Arg Asn Val Val Ile Lys Ile Asn Gly Glu Ala Glu Leu Phe Tyr 
                725                 730                 735     


Arg Asp Lys Ser Asp Ile Ser Lys Thr Glu His Ser Ala Gly Thr Ile 
            740                 745                 750         


Leu Val Asn Arg Thr Asp Arg Lys Asp Asn Pro Ile Pro Asn Ser Ile 
        755                 760                 765             


Tyr Tyr Glu Leu Phe Lys Tyr Lys Thr Gly Gln Ile Lys Ser Val Ser 
    770                 775                 780                 


Asp Glu Ala Lys Gln Tyr Leu Asp Asp Leu Val Thr His Glu Ala Lys 
785                 790                 795                 800 


Tyr Pro Ile Thr Lys Asp Arg Arg Tyr Thr Glu Asp Arg Met Phe Phe 
                805                 810                 815     


His Ile Pro Ile Thr Leu Asn Phe Gly Ser Ser Gly Asn Thr Asn Ile 
            820                 825                 830         


Asn Lys Ala Val Ile Asp His Val Leu Asn Ser Lys Asp Val His Ile 
        835                 840                 845             


Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Val Ser Val Ile 
    850                 855                 860                 


Asp Arg Lys Gly Asn Ile Ile Lys Gln Arg Ser Leu Asn Val Ile Asp 
865                 870                 875                 880 


Gly Ile Asp Tyr His Glu Lys Leu Asp Gln Arg Glu Lys Glu Asn Ile 
                885                 890                 895     


Ser Ala Arg Lys Ser Trp Ser Asn Val Glu Lys Ile Lys Asp Leu Lys 
            900                 905                 910         


Glu Gly Tyr Leu Ser Tyr Val Ile His 
        915                 920     


<210> 10
<211> 1238
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 10
Met Lys Asp Phe Tyr Gln Phe Thr Asn Leu Tyr Ala Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Ser Leu Ile Pro Thr Pro Ala Thr Lys Gln Met Leu Glu 
            20                  25                  30          


Asp Ala Lys Val Phe Glu Lys Asp Glu Thr Ile Gln Lys Lys Tyr Glu 
        35                  40                  45              


Ala Thr Lys Pro Tyr Phe Asp Arg Leu His Arg Glu Phe Ala Leu Glu 
    50                  55                  60                  


Ala Leu Gln Asp Gln Lys Leu Asp Phe Lys Asn Tyr Leu Glu Leu Tyr 
65                  70                  75                  80  


Arg Lys Tyr Lys Ala Asp Lys Lys Ala Ser Gly Lys Leu Leu Ile Asn 
                85                  90                  95      


Ile Glu Lys Asp Leu Arg Lys Glu Val Val Lys Leu Phe Asp Lys Gln 
            100                 105                 110         


Gly Glu Lys Trp Ala Lys Gln Tyr Pro Gly Leu Lys Asn Lys Asn Ile 
        115                 120                 125             


Gly Val Leu Phe Lys Glu Ala Val Phe Thr Val Ile Leu Lys Glu Arg 
    130                 135                 140                 


Tyr Gly Asn Glu Lys Glu Thr Gln Ile Leu Asp Glu Ser Ser Gly Gln 
145                 150                 155                 160 


Leu Val Ser Ile Phe Asp Ser Trp Lys Gly Phe Ile Gly Tyr Phe Lys 
                165                 170                 175     


Lys Phe His Glu Thr Arg Lys Asn Phe Tyr Lys Asp Asp Gly Thr Ser 
            180                 185                 190         


Thr Ala Leu Ala Thr Arg Ile Ile Asp Gln Asn Leu Lys Arg Phe Cys 
        195                 200                 205             


Asp Asn Ile Leu Ile Phe Glu Ser Thr Lys Glu Lys Val Asp Phe Ser 
    210                 215                 220                 


Glu Val Glu Ile Ser Phe Gly Lys Pro Leu Ser Glu Val Phe Thr Leu 
225                 230                 235                 240 


Glu Phe Tyr Asn Thr Cys Phe Leu Gln Asn Gly Ile Asp Phe Tyr Thr 
                245                 250                 255     


Lys Ile Leu Gly Gly Glu Thr Leu Gln Asn Gly Glu Lys Val Lys Gly 
            260                 265                 270         


Leu Asn Glu Cys Ile Asn Leu His Lys Gln Lys Thr Gly Glu Lys Leu 
        275                 280                 285             


Pro Phe Phe Lys Ser Leu Asp Lys Gln Ile Leu Ser Glu Lys Asp Lys 
    290                 295                 300                 


Phe Phe Ile Asp Glu Ile Ser Asn Glu Thr Gln Leu Leu Glu Val Leu 
305                 310                 315                 320 


Lys Ser Phe Val Ala Ser Ala Glu Ser Lys Thr Asp Thr Ile Lys Thr 
                325                 330                 335     


Leu Val Asp Asp Phe Val Lys Asp Gln Asp Lys Tyr Asp Leu Asn Tyr 
            340                 345                 350         


Ile Tyr Phe Ser Asn Asp Gly Leu Asn Thr Ile Thr Arg Lys Trp Thr 
        355                 360                 365             


Thr Glu Thr Gln Val Phe Glu Glu Ala Leu Tyr Thr Ala Leu Lys Ala 
    370                 375                 380                 


Ala Lys Val Val Ser Ser Ser Ala Lys Lys Asn Glu Gly Gly Tyr Ser 
385                 390                 395                 400 


Phe Pro Asp Phe Ile Pro Phe Ala His Leu Lys Thr Ala Leu Glu Ser 
                405                 410                 415     


Ile Lys Ile Asp Gly Thr Ile Trp Arg Asp Asn Phe Asn Ala Ile Glu 
            420                 425                 430         


Asn Phe Glu Glu Lys Ser Ile Trp Ala Gln Phe Leu Ala Ile Tyr Asn 
        435                 440                 445             


Phe Glu Leu Ser Asn Leu Phe Glu Thr Glu Ile Lys Asn Pro Glu Ile 
    450                 455                 460                 


Gly Asn Cys Pro Thr Ile Gly Tyr Asn Val Tyr Lys Gln Asp Phe Glu 
465                 470                 475                 480 


Glu Leu Leu Lys Ser Phe Val Tyr Asp Pro Asn Ala Lys Val Thr Ile 
                485                 490                 495     


Lys Asn Phe Ala Asp Asn Val Leu Ser Ile Tyr Gln Met Ala Lys Tyr 
            500                 505                 510         


Phe Ala Val Glu Lys Lys Arg Gly Trp Asn Thr Asp Tyr Glu Leu Asp 
        515                 520                 525             


Val Phe Tyr Thr Asp Pro Gln Asn Gly Tyr Leu Gln Tyr Tyr Glu Asn 
    530                 535                 540                 


Ala Tyr Glu Glu Ile Val Gln Val Tyr Asn Lys Leu Arg Asn Tyr Leu 
545                 550                 555                 560 


Thr Lys Lys Pro Tyr Ser Glu Glu Lys Trp Lys Leu Asn Phe Asp Ser 
                565                 570                 575     


Gly Thr Pro Ile Lys Tyr Thr Thr Arg Ala Ile Ile Phe Asn Asn Thr 
            580                 585                 590         


Thr Asn Glu Arg Tyr Tyr Leu Gly Leu Leu Lys Lys Gly Val Ala Lys 
        595                 600                 605             


Pro Arg Glu Phe Glu Pro Ile Asn Asn Asn Ile Ile Ser Ser Gly Glu 
    610                 615                 620                 


Phe Arg Arg Met Ile Ile Gln Gln Leu Lys Phe Gln Thr Leu Ala Gly 
625                 630                 635                 640 


Lys Gly Tyr Val Arg Asp Phe Gly Val Lys Tyr Ser Glu Asp Lys Asp 
                645                 650                 655     


Gly Val Lys His Leu Gln Gln Leu Ile Lys Lys Gln Tyr Leu Ser Lys 
            660                 665                 670         


Tyr Pro Cys Leu Lys Lys Ile Ala Asp Gly Val Tyr Asn Asp Lys Lys 
        675                 680                 685             


Ala Phe Asp Ala Asp Ile Lys Asp Val Leu Leu Glu Thr Tyr Asn Leu 
    690                 695                 700                 


Asp Phe Gln Pro Ile Ser Glu Glu Phe Ile Leu Asn Lys Asn Arg Leu 
705                 710                 715                 720 


Gly Glu Ile Tyr Leu Phe Glu Ile His Asn Lys Asp Trp Asn Leu Lys 
                725                 730                 735     


Asp Gly Lys Asn Lys Ser Gly Ser Lys Asn Leu His Thr Met Tyr Phe 
            740                 745                 750         


Glu Ser Leu Phe Val Asp Lys Thr Thr Phe Lys Leu Asn Asn Glu Gly 
        755                 760                 765             


Ala Glu Val Phe Tyr Arg Pro Ala Thr Asn Glu Gly Lys Leu Gly Thr 
    770                 775                 780                 


Lys Lys Asp Arg Asn Gly Lys Ile Ile Ile Asn His Lys Arg Tyr Ala 
785                 790                 795                 800 


Thr Asp Lys Ile Leu Phe His Cys Pro Ile Gly Leu Asn Lys Asp Ala 
                805                 810                 815     


Gly Lys Ser Tyr Thr Phe Asn Ala Lys Ile Asn Asn Met Leu Ala Asn 
            820                 825                 830         


Asn Pro Asp Ile Asn Ile Ile Gly Val Asp Arg Gly Glu Lys His Leu 
        835                 840                 845             


Ala Tyr Tyr Ser Val Ile Thr Gln Lys Gly Lys Ile Leu Asp Arg Gly 
    850                 855                 860                 


Ser Leu Asn Lys Val Glu Gly Gly Asp Lys Gln Glu Ile Asp Tyr Ala 
865                 870                 875                 880 


Lys Lys Leu Glu Glu Thr Ala Lys Asn Arg Glu Gln Ala Arg Lys Asp 
                885                 890                 895     


Trp Gln Ala Val Glu Gly Ile Lys Asp Leu Lys Arg Gly Tyr Ile Ser 
            900                 905                 910         


Gln Val Val Arg Lys Leu Ala Asp Leu Ala Ile Glu His Asn Ala Ile 
        915                 920                 925             


Ile Val Phe Glu Asp Leu Asn Met Arg Phe Lys Gln Ile Arg Gly Gly 
    930                 935                 940                 


Ile Glu Lys Ser Val Tyr Gln Gln Leu Glu Lys Ala Leu Ile Asp Lys 
945                 950                 955                 960 


Leu Ser Phe Leu Val Met Lys Gly Glu Ala Asp Pro Glu Lys Ala Gly 
                965                 970                 975     


His Leu Leu Lys Ala Tyr Gln Leu Val Ala Pro Phe Glu Ser Phe Gln 
            980                 985                 990         


Ser Met Gly Lys Gln Thr Gly Ile  Ile Phe Tyr Thr Gln  Ala Asn Tyr 
        995                 1000                 1005             


Thr Ser  Lys Ile Asp Pro Ile  Thr Gly Trp Arg Pro  Asn Leu Tyr 
    1010                 1015                 1020             


Leu Lys  Tyr Thr Ser Ala Glu  Lys Ala Lys Ala Asp  Ile Leu Lys 
    1025                 1030                 1035             


Phe Ser  Lys Ile Glu Phe Val  Asn Asn Arg Phe Glu  Leu Thr Tyr 
    1040                 1045                 1050             


Asp Ile  Lys Asn Phe Val Leu  Asp Lys Lys Val Val  Leu Ser Asn 
    1055                 1060                 1065             


Lys Thr  Lys Trp Thr Val Cys  Ser Ser Val Glu Arg  Phe Arg Trp 
    1070                 1075                 1080             


Asn Arg  Arg Leu Glu Ser Asn  Gln Gly Asn Tyr Glu  His Tyr Glu 
    1085                 1090                 1095             


Asn Leu  Thr Glu Asn Leu Ser  Ser Leu Phe Lys Asp  Phe Gly Phe 
    1100                 1105                 1110             


Glu Ile  Glu Gln Asn Ile Ile  Arg Gln Val Glu Gln  Leu Ala Thr 
    1115                 1120                 1125             


Lys Gly  Asn Glu Gln Phe Phe  Arg Ser Phe Ile Phe  Tyr Val Asn 
    1130                 1135                 1140             


Leu Ile  Phe Gln Ile Arg Asn  Thr Asp Ala Lys Ala  Lys Asp Gln 
    1145                 1150                 1155             


Asn Lys  Glu Asp Phe Ile Leu  Ser Pro Val Glu Pro  Phe Phe Asp 
    1160                 1165                 1170             


Ser Arg  Thr Pro Glu Lys Phe  Gly Glu Asn Leu Pro  Glu Asn Gly 
    1175                 1180                 1185             


Asp Asp  Asn Gly Ala Phe Asn  Ile Ala Arg Lys Gly  Ile Ile Met 
    1190                 1195                 1200             


Leu Asn  Lys Ile Ser Ala Tyr  Lys Gln Glu Val Gly  Asn Val Asp 
    1205                 1210                 1215             


Lys Ile  Ile Trp Lys Asp Leu  Phe Ile Ser Ala Ala  Glu Trp Asp 
    1220                 1225                 1230             


Asn Phe  Thr Gln Glu 
    1235             


<210> 11
<211> 1301
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 11
Met Asp Ser Tyr Glu Gln Phe Thr Lys Leu Tyr Pro Ile Gln Lys Thr 
1               5                   10                  15      


Ile Arg Phe Glu Leu Lys Pro Gln Gly Arg Thr Lys Glu His Phe Asp 
            20                  25                  30          


Asn Ser Asn Phe Leu Glu Lys Asp Arg Glu Arg Asp Asp Asn Tyr Lys 
        35                  40                  45              


Ile Leu Lys Glu Val Ile Asp Asp Tyr His Arg Glu Phe Ile Asp Glu 
    50                  55                  60                  


Cys Leu Ser Asn Ile Gln Leu Asn Trp Asp Asp Leu Lys Lys Phe Ser 
65                  70                  75                  80  


Glu Glu Tyr Arg Arg Ser Lys Glu Lys Lys Asn Asn Arg Asp Ser Glu 
                85                  90                  95      


Ser Glu Gln Lys Arg Met Ser Thr Thr Ser Glu Thr Arg Ala Ile Asn 
            100                 105                 110         


Lys Lys Asn Leu Glu Ala Glu Gln Lys Arg Met Arg Gly Glu Ile Val 
        115                 120                 125             


Ser Ala Phe Lys Lys Asp Asp Arg Phe Lys His Leu Phe Ser Glu Lys 
    130                 135                 140                 


Leu Phe Ser Ile Leu Leu Lys Asn Gln Ile Tyr Glu Lys Gly Thr Leu 
145                 150                 155                 160 


Glu Glu Ile Glu Ala Phe Asp Cys Phe Asn Lys Phe Ser Gly Tyr Phe 
                165                 170                 175     


Lys Ser Phe His Glu Asn Arg Lys Asn Met Tyr Ser Asp Glu Asp Lys 
            180                 185                 190         


Glu Thr Ala Ile Ser Tyr Arg Ile Ile Asn Glu Asn Phe Pro Lys Leu 
        195                 200                 205             


Leu Asp Asn Phe Glu Lys Tyr Gln Tyr Val Cys Arg Glu Tyr Pro Glu 
    210                 215                 220                 


Gln Ile Arg Glu Ala Glu Ser Thr Leu Ala Glu Ala Gly Cys Tyr Ile 
225                 230                 235                 240 


Lys Met Asp Glu Ile Phe Ser Ile Asp Asn Phe Asn Asn Val Met Met 
                245                 250                 255     


Gln Gly Gly Lys Glu Ser Gly Ile Ser Arg Tyr Asn Leu Ala Ile Gly 
            260                 265                 270         


Gly Ile Val Gln Gly Thr Gly Glu Lys Pro Lys Gly Leu Asn Glu Phe 
        275                 280                 285             


Leu Asn Leu Ala Tyr Gln Asn Glu Pro Asn Gly Arg Lys Lys Ile Arg 
    290                 295                 300                 


Met Glu Pro Leu Tyr Lys Gln Ile Leu Ser Lys Glu Glu Ser Phe Ser 
305                 310                 315                 320 


Tyr Arg Leu Glu Ala Phe Thr Asp Asp Ser Gln Leu Leu Ser Ala Ile 
                325                 330                 335     


Arg Ser Phe Phe Asp Ile Val Glu Lys Asp Lys Asn Gly Asn Ile Phe 
            340                 345                 350         


Asp Arg Ala Val Asn Leu Met Ser Ser Phe Ser Asn Tyr Asp Thr Ser 
        355                 360                 365             


Lys Ile Tyr Ile Arg Lys Ala Tyr Leu Asn Gln Val Ser Lys Glu Ile 
    370                 375                 380                 


Phe Gly Tyr Arg Gly Lys Ser Asp Ser Lys Pro Ala Lys Thr Ala Asp 
385                 390                 395                 400 


Glu Ser Leu Asn Lys Ser Gly Gly Trp Glu Lys Leu Gly Gln Met Leu 
                405                 410                 415     


Arg Asp Tyr Lys Ala Asp Ser Ile Gly Asp Arg Asn Leu Glu Lys Thr 
            420                 425                 430         


Cys Lys Lys Val Asp Lys Trp Leu Asp Ser Asp Glu Phe Thr Leu Ser 
        435                 440                 445             


Asp Ile Leu Gly Ala Ile Ser Leu Ala Gly Ser Asn Glu Thr Phe Glu 
    450                 455                 460                 


Ala Tyr Val Ser Glu Ile Cys Val Ala Arg Arg Asn Ile Asp Lys Glu 
465                 470                 475                 480 


Lys Glu Lys Glu Lys Asn Ile Asn Val Glu Lys Ile Ser Gly Asp Thr 
                485                 490                 495     


Glu Ser Ile Gln Ile Ile Lys Ala Leu Leu Asp Ser Val Gln Glu Phe 
            500                 505                 510         


Phe His Leu Leu Ser Pro Phe Gln Leu His Pro Asn Thr Pro His Asp 
        515                 520                 525             


Trp Thr Phe Tyr Ala Glu Phe Asn Asp Ile Tyr Asp Lys Leu Ser Ala 
    530                 535                 540                 


Ile Thr Pro Leu Tyr Asn Gln Ala Arg Asn His Leu Thr Lys Lys Asn 
545                 550                 555                 560 


Leu Asp Thr Ser Lys Ile Lys Leu Asn Phe Asn Asn Pro Thr Leu Ala 
                565                 570                 575     


Asn Gly Trp Asp Val Asn Lys Glu Tyr Glu Asn Thr Ala Val Ile Leu 
            580                 585                 590         


Ile Arg Asp Gly Lys Tyr Tyr Leu Gly Ile Met Asn Pro Lys Asn Lys 
        595                 600                 605             


Arg Lys Ile Lys Phe Asp Glu Gly Ser Gly Ala Gly Pro Phe Tyr Gln 
    610                 615                 620                 


Lys Met Val Tyr Lys Leu Leu Pro Gly Pro Tyr Arg Met Leu Pro Lys 
625                 630                 635                 640 


Val Phe Phe Ala Lys Lys Asn Ile Asp Tyr Tyr Asn Pro Ser Gln Glu 
                645                 650                 655     


Ile Arg Glu Gly Tyr Lys Ala Gly Lys His Lys Lys Gly Lys Glu Phe 
            660                 665                 670         


Asp Lys Gly Phe Cys His Lys Leu Ile Asp Phe Phe Lys Glu Ser Ile 
        675                 680                 685             


Gln Lys Asn Glu Asn Trp Lys Val Phe Asp Phe Lys Phe Ser Pro Thr 
    690                 695                 700                 


Glu Ser Tyr Asp Asp Ile Ser Glu Phe Tyr Gln Glu Val Glu Lys Gln 
705                 710                 715                 720 


Gly Tyr Arg Met Tyr Phe Val Asn Ile Pro Ser Asp Thr Ile Asp Arg 
                725                 730                 735     


Tyr Val Glu Gly Gly Asp Met Phe Leu Phe Gln Ile Tyr Asn Lys Asp 
            740                 745                 750         


Phe Ala Lys Gly Ala Lys Gly Asn Lys Asp Met His Thr Leu Tyr Trp 
        755                 760                 765             


Asn Ala Val Phe Ser Glu Glu Asn Leu Gln Lys Gly Val Met Lys Leu 
    770                 775                 780                 


Ser Gly Glu Ala Glu Leu Phe Tyr Arg Lys Lys Ser Asp Ile Lys Asp 
785                 790                 795                 800 


Pro Pro His Arg Glu Gly Glu Ile Leu Val Asn Arg Thr Tyr Ile Asp 
                805                 810                 815     


Arg Thr His Val Ser Gly Val Met Gly Glu Gln Asn Thr Val Lys Glu 
            820                 825                 830         


Ser Arg Ile Pro Val Pro Asp Glu Ile His Lys Asn Leu Phe Asp Tyr 
        835                 840                 845             


Tyr Asn His Gly Arg Glu Leu Thr Lys Glu Glu Lys Glu Tyr Cys Asp 
    850                 855                 860                 


Lys Val Gly Ser Phe Lys Ala Tyr Tyr Gly Ile Val Lys Asp Arg Arg 
865                 870                 875                 880 


Tyr Leu Glu Asn Lys Met Tyr Phe His Val Pro Leu Thr Leu Asn Phe 
                885                 890                 895     


Lys Ala Ile Gly Glu Lys Arg Ile Asn Lys Met Ala Ile Glu Lys Phe 
            900                 905                 910         


Leu Thr Asp Glu Asn Ala Cys Ile Ile Gly Ile Asp Arg Gly Glu Arg 
        915                 920                 925             


Asn Leu Leu Tyr Tyr Ser Ile Ile Asp Arg Asn Gly Lys Ile Ile Asp 
    930                 935                 940                 


Gln Lys Ser Leu Asn Val Ile Asp Gly Phe Asp Tyr His Glu Lys Leu 
945                 950                 955                 960 


Ser Gln Arg Gln Thr Glu Arg Glu Val Ala Arg Gln Ser Trp Asn Ser 
                965                 970                 975     


Ile Gly Lys Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ala Lys Ala Val 
            980                 985                 990         


His Glu Ile Ser Lys Met Ala Ile  Lys Tyr Asn Ala Ile  Val Val Leu 
        995                 1000                 1005             


Glu Asp  Leu His Phe Gly Phe  Lys Lys Gly Arg Leu  Lys Val Glu 
    1010                 1015                 1020             


Lys Gln  Ile Tyr Gln Lys Phe  Glu Glu Met Leu Ile  Asn Lys Leu 
    1025                 1030                 1035             


Asn Tyr  Leu Val Phe Lys Asp  Val Ser Asp Ser Ser  Asp Ala Gly 
    1040                 1045                 1050             


Gly Val  Leu Asn Ala Tyr Gln  Leu Thr Ala Pro Leu  Glu Ser Phe 
    1055                 1060                 1065             


Ser Lys  Leu Gly Lys Gln Ser  Gly Ile Leu Phe Tyr  Val Pro Ala 
    1070                 1075                 1080             


Ala Phe  Thr Ser Val Ile Asp  Pro Thr Thr Gly Phe  Val Asp Leu 
    1085                 1090                 1095             


Phe Asn  Ser Ser Ser Ile Thr  Ser Thr Gln Lys Lys  Lys Glu Phe 
    1100                 1105                 1110             


Leu Gln  Arg Phe Glu Ser Ile  Val Tyr Ser Ala Arg  Asp Gly Gly 
    1115                 1120                 1125             


Ile Phe  Ala Phe Thr Phe Asp  Tyr Arg Asn Phe Ser  Lys Ile Ala 
    1130                 1135                 1140             


Thr Asp  His Arg Asn Met Trp  Thr Val Tyr Thr His  Gly Glu Arg 
    1145                 1150                 1155             


Ile Arg  Tyr Val Arg Asp Glu  Lys Cys Tyr Lys Thr  Thr Asp Pro 
    1160                 1165                 1170             


Thr Lys  Arg Ile Lys Glu Ala  Leu Ser Gly Ile Glu  Tyr Asp Asp 
    1175                 1180                 1185             


Gly Ser  Asp Ile Arg Asp Lys  Ile Thr Gln Ser Gly  Asp Asn Asn 
    1190                 1195                 1200             


Leu Ile  Asn Thr Val Tyr His  Ser Phe Met Asp Thr  Ile Lys Met 
    1205                 1210                 1215             


Arg Asn  Lys Asp Gly Arg Ile  Asp Tyr Ile Ile Ser  Pro Val Lys 
    1220                 1225                 1230             


Asn Arg  Asn Gly Glu Phe Phe  Arg Ser Asp Tyr Lys  His Arg Asp 
    1235                 1240                 1245             


Phe Pro  Val Asp Ala Asp Ala  Asn Gly Ala Tyr His  Ile Ala Leu 
    1250                 1255                 1260             


Lys Gly  Glu Leu Leu Met Arg  Met Ile Gly Lys Thr  Tyr Asp Ser 
    1265                 1270                 1275             


Asn Ser  Asp Lys Met Pro Lys  Leu Glu His Lys Asp  Trp Phe Glu 
    1280                 1285                 1290             


Phe Met  Gln Thr Arg Gly Asp  Gln 
    1295                 1300     


<210> 12
<211> 1368
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 12
Met Lys Lys Glu Lys Glu Phe Lys Ser Phe Gly Asp Phe Thr Asn Leu 
1               5                   10                  15      


Tyr Glu Ile Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Glu Asn 
            20                  25                  30          


Thr Gln Thr Met Leu Asp Glu Ala Asp Val Phe Gly Lys Asp Lys Val 
        35                  40                  45              


Ile Lys Asp Lys Tyr Thr Lys Thr Lys Pro Phe Ile Asp Lys Leu His 
    50                  55                  60                  


Arg Glu Phe Val Asp Glu Ser Leu Lys Asp Val Ser Leu Ser Gly Leu 
65                  70                  75                  80  


Lys Lys Tyr Ser Glu Val Leu Glu Asn Trp Lys Lys Asn Lys Lys Asp 
                85                  90                  95      


Lys Asp Ile Val Lys Glu Leu Lys Lys Glu Glu Glu Arg Leu Arg Lys 
            100                 105                 110         


Glu Val Val Glu Phe Phe Asp Asn Thr Ala Lys Lys Trp Ala Asn Glu 
        115                 120                 125             


Lys Tyr Lys Glu Leu Gly Leu Lys Lys Lys Asp Ile Gly Ile Leu Phe 
    130                 135                 140                 


Glu Glu Ser Val Phe Asp Leu Leu Lys Glu Lys Tyr Gly Glu Glu Gln 
145                 150                 155                 160 


Asp Ser Phe Leu Lys Glu Glu Lys Gly Asp Phe Leu Lys Asn Glu Lys 
                165                 170                 175     


Gly Glu Lys Val Ser Ile Phe Asp Glu Trp Lys Gly Phe Val Gly Tyr 
            180                 185                 190         


Phe Thr Lys Phe Gln Glu Thr Arg Lys Asn Phe Tyr Lys Asn Asp Gly 
        195                 200                 205             


Thr Glu Thr Ala Leu Ala Thr Arg Ile Ile Asp Gln Asn Leu Lys Arg 
    210                 215                 220                 


Phe Cys Asp Asn Ile Asp Asp Phe Lys Lys Ile Lys Asn Lys Ile Asp 
225                 230                 235                 240 


Phe Ser Glu Val Glu Lys Asn Phe Asn Lys Thr Ala Asp Val Phe Ser 
                245                 250                 255     


Leu Asp Phe Tyr Asn Gln Cys Leu Leu Gln Lys Gly Ile Asp Ser Tyr 
            260                 265                 270         


Asn Glu Phe Ile Gly Gly Lys Thr Leu Glu Asn Gly Lys Lys Leu Lys 
        275                 280                 285             


Gly Val Asn Glu Leu Val Asn Glu Tyr Arg Gln Lys Asn Lys Asn Glu 
    290                 295                 300                 


Lys Val Ser Phe Leu Lys Leu Leu Asp Lys Gln Ile Leu Ser Glu Lys 
305                 310                 315                 320 


Glu Lys Leu Ser Phe Gly Ile Glu Asn Asp Glu Gln Leu Leu Val Val 
                325                 330                 335     


Leu Asn Ser Phe Tyr Glu Thr Ala Glu Glu Lys Thr Lys Ile Leu Arg 
            340                 345                 350         


Thr Leu Phe Gly Asp Phe Val Glu His Asn Glu Asn Tyr Asp Leu Asp 
        355                 360                 365             


Lys Thr Tyr Ile Ser Lys Val Ala Phe Asn Thr Ile Ser His Lys Trp 
    370                 375                 380                 


Thr Asn Glu Thr His Lys Phe Glu Glu Leu Leu Tyr Gly Ala Met Lys 
385                 390                 395                 400 


Glu Asp Lys Pro Ile Gly Leu Asn Tyr Asp Lys Lys Glu Asp Ser Tyr 
                405                 410                 415     


Lys Phe Pro Asp Phe Ile Ala Leu Gly Tyr Leu Lys Lys Cys Leu Asn 
            420                 425                 430         


Asn Leu Asp Cys Asp Thr Lys Phe Trp Lys Glu Lys Tyr Tyr Glu Asn 
        435                 440                 445             


Asn Ala Asp Lys Lys Asp Lys Asp Lys Gly Phe Leu Thr Gly Gly Gln 
    450                 455                 460                 


Asn Ala Trp Asp Gln Phe Leu Gln Ile Phe Ile Phe Glu Phe Asn Gln 
465                 470                 475                 480 


Leu Phe Asn Ser Glu Ala Phe Asp Asn Lys Gly Lys Glu Ile Lys Ile 
                485                 490                 495     


Gly Tyr Asp Asn Phe Arg Lys Asp Phe Glu Glu Ile Ile Asn Gln Lys 
            500                 505                 510         


Asp Phe Lys Asn Asp Glu Asn Leu Lys Ile Ala Ile Lys Asn Phe Ala 
        515                 520                 525             


Asp Ser Val Leu Trp Ile Tyr Gln Met Ala Lys Tyr Phe Ala Ile Glu 
    530                 535                 540                 


Lys Lys Arg Gly Trp Asp Asp Asp Phe Glu Leu Ser Glu Phe Tyr Thr 
545                 550                 555                 560 


Asn Pro Ser Asn Gly Tyr Ser Leu Phe Tyr Asp Arg Ala Tyr Glu Glu 
                565                 570                 575     


Ile Val Gln Lys Tyr Asn Asp Leu Arg Asn Tyr Leu Thr Lys Lys Pro 
            580                 585                 590         


Tyr Lys Glu Asp Lys Trp Lys Leu Asn Phe Glu Asn Pro Thr Leu Ala 
        595                 600                 605             


Asn Gly Phe Asp Lys Asn Lys Glu Ser Asp Asn Ser Thr Val Ile Leu 
    610                 615                 620                 


Arg Lys Lys Arg Lys Tyr Tyr Leu Gly Leu Met Lys Lys Gly Asn Asn 
625                 630                 635                 640 


Lys Ile Phe Glu Asp Arg Asn Lys Ala Glu Phe Ile Arg Asn Ile Glu 
                645                 650                 655     


Ser Gly Ala Tyr Glu Lys Met Ala Tyr Lys Tyr Leu Pro Asp Val Ala 
            660                 665                 670         


Lys Met Ile Pro Lys Cys Ser Thr Gln Leu Asn Glu Ala Lys Asn His 
        675                 680                 685             


Phe Arg Asn Ser Ala Asp Asp Leu Glu Ile Lys Lys Ser Phe Ser Asn 
    690                 695                 700                 


Pro Leu Lys Ile Thr Lys Arg Ile Phe Asp Leu Asn Asn Ile Gln Tyr 
705                 710                 715                 720 


Asp Lys Thr Asn Val Ser Lys Lys Ile Ser Gly Asp Asn Lys Gly Ile 
                725                 730                 735     


Lys Ile Phe Gln Lys Glu Tyr Tyr Lys Ile Ser Gly Asp Phe Asp Val 
            740                 745                 750         


Tyr Lys Ser Ala Leu Asn Asp Trp Ile Asp Phe Cys Lys Asp Phe Leu 
        755                 760                 765             


Ser Lys Tyr Asp Ser Thr Lys Asp Phe Asp Phe Ser Ile Leu Arg Lys 
    770                 775                 780                 


Thr Lys Asp Tyr Lys Ser Leu Asp Glu Phe Tyr Val Asp Val Ala Lys 
785                 790                 795                 800 


Ile Thr Tyr Lys Ile Ser Phe Thr Pro Val Ser Glu Ser Tyr Ile Asp 
                805                 810                 815     


Gln Lys Asn Lys Asn Gly Glu Leu Tyr Leu Phe Glu Ile Tyr Asn Gln 
            820                 825                 830         


Asp Phe Ala Lys Gly Lys Met Gly Ala Lys Asn Leu His Thr Leu Tyr 
        835                 840                 845             


Phe Glu Asn Val Phe Ser Pro Glu Asn Ile Ser Lys Asn Phe Pro Ile 
    850                 855                 860                 


Lys Leu Asn Gly Asn Ala Glu Leu Phe Phe Arg Pro Lys Ser Ile Glu 
865                 870                 875                 880 


Ser Lys Lys Glu Lys Arg Asn Phe Val Arg Glu Ile Val Asn Lys Lys 
                885                 890                 895     


Arg Tyr Ser Glu Asp Lys Ile Phe Phe His Cys Pro Ile Thr Leu Asn 
            900                 905                 910         


Arg Glu Thr Gly Ser Ile Tyr Arg Phe Asn Asn Tyr Val Asn Asn Phe 
        915                 920                 925             


Leu Ser Glu Asn Asn Ile Asn Ile Ile Gly Val Asp Arg Gly Glu Lys 
    930                 935                 940                 


His Leu Ala Tyr Tyr Ser Val Ile Asp Lys Asn Gly Val Lys Ile Gly 
945                 950                 955                 960 


Gly Gly Ser Phe Asn Glu Ile Asn Lys Val Asp Tyr Ala Lys Lys Leu 
                965                 970                 975     


Glu Glu Arg Ala Gly Glu Arg Glu Gln Ser Arg Lys Asp Trp Gln Val 
            980                 985                 990         


Val Glu Gly Ile Lys Asp Leu Lys  Lys Gly Tyr Ile Ser  Gln Val Val 
        995                 1000                 1005             


Arg Glu  Leu Ala Asp Leu Ala  Ile Lys His Asn Ala  Ile Ile Val 
    1010                 1015                 1020             


Leu Glu  Asp Leu Asn Met Arg  Phe Lys Gln Ile Arg  Gly Gly Ile 
    1025                 1030                 1035             


Glu Lys  Ser Ile Tyr Gln Gln  Leu Glu Lys Ala Leu  Ile Asp Lys 
    1040                 1045                 1050             


Leu Ser  Phe Leu Val Glu Lys  Gly Glu Lys Asp Pro  Asn Gln Ala 
    1055                 1060                 1065             


Gly His  Ile Leu Lys Ala Tyr  Gln Leu Ala Ala Pro  Phe Thr Ser 
    1070                 1075                 1080             


Phe Lys  Asp Met Gly Lys Gln  Thr Gly Ile Val Phe  Tyr Thr Gln 
    1085                 1090                 1095             


Ala Ser  Tyr Thr Ser Lys Thr  Cys Pro Asn Cys Gly  Phe Arg Lys 
    1100                 1105                 1110             


Asn Asn  Asn Lys Phe Tyr Phe  Glu Asn Asn Ile Gly  Lys Ala Gln 
    1115                 1120                 1125             


Asp Ala  Leu Lys Lys Leu Lys  Thr Phe Glu Tyr Asp  Ser Glu Asn 
    1130                 1135                 1140             


Lys Cys  Phe Gly Leu Ser Tyr  Cys Leu Ser Asp Phe  Ala Asn Lys 
    1145                 1150                 1155             


Glu Glu  Val Glu Lys Asn Lys  Asn Lys Lys Arg Asn  Asn Ala Pro 
    1160                 1165                 1170             


Tyr Ser  Asp Ile Glu Lys Lys  Asp Cys Phe Glu Leu  Ser Thr Lys 
    1175                 1180                 1185             


Asp Ala  Val Arg Tyr Arg Trp  His Asp Lys Asn Thr  Glu Arg Gly 
    1190                 1195                 1200             


Lys Thr  Phe Phe Glu Gly Glu  Ser Val Tyr Glu Glu  Lys Glu Glu 
    1205                 1210                 1215             


Lys Glu  Ile Gly Gln Thr Lys  Arg Gly Leu Val Lys  Glu Tyr Asp 
    1220                 1225                 1230             


Ile Ser  Lys Cys Leu Ile Gly  Leu Phe Glu Lys Thr  Gly Leu Asp 
    1235                 1240                 1245             


Tyr Lys  Gln Asn Leu Leu Asp  Lys Ile Asn Ser Gly  Lys Phe Asp 
    1250                 1255                 1260             


Gly Thr  Phe Tyr Lys Asn Leu  Phe Asn Tyr Leu Asn  Leu Leu Phe 
    1265                 1270                 1275             


Glu Ile  Arg Asn Ser Ile Ser  Gly Thr Glu Ile Asp  Tyr Ile Ser 
    1280                 1285                 1290             


Cys Pro  Glu Cys Gln Phe His  Thr Asp Lys Ser Lys  Thr Ile Lys 
    1295                 1300                 1305             


Asn Gly  Asp Asp Asn Gly Ser  Tyr Asn Ile Ala Arg  Lys Gly Met 
    1310                 1315                 1320             


Ile Ile  Leu Asp Lys Ile Lys  Gln Phe Lys Lys Glu  Asn Gly Ser 
    1325                 1330                 1335             


Leu Asp  Lys Met Gly Trp Gly  Glu Leu Phe Ile Asp  Leu Glu Glu 
    1340                 1345                 1350             


Trp Asp  Lys Phe Ala Gln Lys  Lys Asn Asn Asn Ile  Ile Asp Lys 
    1355                 1360                 1365             


<210> 13
<211> 1285
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 13
Met Lys Ser Phe Asp Ser Phe Thr Asn Leu Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Lys Phe Glu Met Arg Pro Val Gly Asn Thr Gln Lys Met Leu Asp 
            20                  25                  30          


Asn Ala Gly Val Phe Glu Lys Asp Lys Leu Ile Gln Lys Lys Tyr Gly 
        35                  40                  45              


Lys Thr Lys Pro Tyr Phe Asp Arg Leu His Arg Glu Phe Ile Glu Glu 
    50                  55                  60                  


Ala Leu Thr Gly Val Glu Leu Ile Gly Leu Asp Glu Asn Phe Arg Thr 
65                  70                  75                  80  


Leu Val Asp Trp Gln Lys Asp Lys Lys Asn Asn Val Ala Met Lys Ala 
                85                  90                  95      


Tyr Glu Asn Ser Leu Gln Arg Leu Arg Thr Glu Ile Gly Lys Ile Phe 
            100                 105                 110         


Asn Leu Lys Ala Glu Asp Trp Val Lys Asn Lys Tyr Pro Ile Leu Gly 
        115                 120                 125             


Leu Lys Asn Lys Asn Thr Asp Ile Leu Phe Glu Glu Ala Val Phe Gly 
    130                 135                 140                 


Ile Leu Lys Ala Arg Tyr Gly Glu Glu Lys Asp Thr Phe Ile Glu Val 
145                 150                 155                 160 


Glu Glu Ile Asp Lys Thr Gly Lys Ser Lys Ile Asn Gln Ile Ser Ile 
                165                 170                 175     


Phe Asp Ser Trp Lys Gly Phe Thr Gly Tyr Phe Lys Lys Phe Phe Glu 
            180                 185                 190         


Thr Arg Lys Asn Phe Tyr Lys Asn Asp Gly Thr Ser Thr Ala Ile Ala 
        195                 200                 205             


Thr Arg Ile Ile Asp Gln Asn Leu Lys Arg Phe Ile Asp Asn Leu Ser 
    210                 215                 220                 


Ile Val Glu Ser Val Arg Gln Lys Val Asp Leu Ala Glu Thr Glu Lys 
225                 230                 235                 240 


Ser Phe Ser Ile Ser Leu Ser Gln Phe Phe Ser Ile Asp Phe Tyr Asn 
                245                 250                 255     


Lys Cys Leu Leu Gln Asp Gly Ile Asp Tyr Tyr Asn Lys Ile Ile Gly 
            260                 265                 270         


Gly Glu Thr Leu Lys Asn Gly Glu Lys Leu Ile Gly Leu Asn Glu Leu 
        275                 280                 285             


Ile Asn Gln Tyr Arg Gln Asn Asn Lys Asp Gln Lys Ile Pro Phe Phe 
    290                 295                 300                 


Lys Leu Leu Asp Lys Gln Ile Leu Ser Glu Lys Ile Leu Phe Leu Asp 
305                 310                 315                 320 


Glu Ile Lys Asn Asp Thr Glu Leu Ile Glu Ala Leu Ser Gln Phe Ala 
                325                 330                 335     


Lys Thr Ala Glu Glu Lys Thr Lys Ile Val Lys Lys Leu Phe Ala Asp 
            340                 345                 350         


Phe Val Glu Asn Asn Ser Lys Tyr Asp Leu Ala Gln Ile Tyr Ile Ser 
        355                 360                 365             


Gln Glu Ala Phe Asn Thr Ile Ser Asn Lys Trp Thr Ser Glu Thr Glu 
    370                 375                 380                 


Thr Phe Ala Lys Tyr Leu Phe Glu Ala Met Lys Ser Gly Lys Leu Ala 
385                 390                 395                 400 


Lys Tyr Glu Lys Lys Asp Asn Ser Tyr Lys Phe Pro Asp Phe Ile Ala 
                405                 410                 415     


Leu Ser Gln Met Lys Ser Ala Leu Leu Ser Ile Ser Leu Glu Gly His 
            420                 425                 430         


Phe Trp Lys Glu Lys Tyr Tyr Lys Ile Ser Lys Phe Gln Glu Lys Thr 
        435                 440                 445             


Asn Trp Glu Gln Phe Leu Ala Ile Phe Leu Tyr Glu Phe Asn Ser Leu 
    450                 455                 460                 


Phe Ser Asp Lys Ile Asn Thr Lys Asp Gly Glu Thr Lys Gln Val Gly 
465                 470                 475                 480 


Tyr Tyr Leu Phe Ala Lys Asp Leu His Asn Leu Ile Leu Ser Glu Gln 
                485                 490                 495     


Ile Asp Ile Pro Lys Asp Ser Lys Val Thr Ile Lys Asp Phe Ala Asp 
            500                 505                 510         


Ser Val Leu Thr Ile Tyr Gln Met Ala Lys Tyr Phe Ala Val Glu Lys 
        515                 520                 525             


Lys Arg Ala Trp Leu Ala Glu Tyr Glu Leu Asp Ser Phe Tyr Thr Gln 
    530                 535                 540                 


Pro Asp Thr Gly Tyr Leu Gln Phe Tyr Asp Asn Ala Tyr Glu Asp Ile 
545                 550                 555                 560 


Val Gln Val Tyr Asn Lys Leu Arg Asn Tyr Leu Thr Lys Lys Pro Tyr 
                565                 570                 575     


Ser Glu Glu Lys Trp Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn 
            580                 585                 590         


Gly Trp Asp Lys Asn Lys Glu Ser Asp Asn Ser Ala Val Ile Leu Gln 
        595                 600                 605             


Lys Gly Gly Lys Tyr Tyr Leu Gly Leu Ile Thr Lys Gly His Asn Lys 
    610                 615                 620                 


Ile Phe Asp Asp Arg Phe Gln Glu Lys Phe Ile Val Gly Ile Glu Gly 
625                 630                 635                 640 


Gly Lys Tyr Glu Lys Ile Val Tyr Lys Phe Phe Pro Asp Gln Ala Lys 
                645                 650                 655     


Met Phe Pro Lys Val Cys Phe Ser Ala Lys Gly Leu Glu Phe Phe Arg 
            660                 665                 670         


Pro Ser Glu Glu Ile Leu Arg Ile Tyr Asn Asn Ala Glu Phe Lys Lys 
        675                 680                 685             


Gly Glu Thr Tyr Ser Ile Asp Ser Met Gln Lys Leu Ile Asp Phe Tyr 
    690                 695                 700                 


Lys Asp Cys Leu Thr Lys Tyr Glu Gly Trp Ala Cys Tyr Thr Phe Arg 
705                 710                 715                 720 


His Leu Lys Pro Thr Glu Glu Tyr Gln Asn Asn Ile Gly Glu Phe Phe 
                725                 730                 735     


Arg Asp Val Ala Glu Asp Gly Tyr Arg Ile Asp Phe Gln Gly Ile Ser 
            740                 745                 750         


Asp Gln Tyr Ile His Glu Lys Asn Glu Lys Gly Glu Leu His Leu Phe 
        755                 760                 765             


Glu Ile His Asn Lys Asp Trp Asn Leu Asp Lys Ala Arg Asp Gly Lys 
    770                 775                 780                 


Ser Lys Thr Thr Gln Lys Asn Leu His Thr Leu Tyr Phe Glu Ser Leu 
785                 790                 795                 800 


Phe Ser Asn Asp Asn Val Val Gln Asn Phe Pro Ile Lys Leu Asn Gly 
                805                 810                 815     


Gln Ala Glu Ile Phe Tyr Arg Pro Lys Thr Glu Lys Asp Lys Leu Glu 
            820                 825                 830         


Ser Lys Lys Asp Lys Lys Gly Asn Lys Val Ile Asp His Lys Arg Tyr 
        835                 840                 845             


Ser Glu Asn Lys Ile Phe Phe His Val Pro Leu Thr Leu Asn Arg Thr 
    850                 855                 860                 


Lys Asn Asp Ser Tyr Arg Phe Asn Ala Gln Ile Asn Asn Phe Leu Ala 
865                 870                 875                 880 


Asn Asn Lys Asp Ile Asn Ile Ile Gly Val Asp Arg Gly Glu Lys His 
                885                 890                 895     


Leu Val Tyr Tyr Ser Val Ile Thr Gln Ala Ser Asp Ile Leu Glu Ser 
            900                 905                 910         


Gly Ser Leu Asn Glu Leu Asn Gly Val Asn Tyr Ala Glu Lys Leu Gly 
        915                 920                 925             


Lys Lys Ala Glu Asn Arg Glu Gln Ala Arg Arg Asp Trp Gln Asp Val 
    930                 935                 940                 


Gln Gly Ile Lys Asp Leu Lys Lys Gly Tyr Ile Ser Gln Val Val Arg 
945                 950                 955                 960 


Lys Leu Ala Asp Leu Ala Ile Lys His Asn Ala Ile Ile Ile Leu Glu 
                965                 970                 975     


Asp Leu Asn Met Arg Phe Lys Gln Val Arg Gly Gly Ile Glu Lys Ser 
            980                 985                 990         


Ile Tyr Gln Gln Leu Glu Lys Ala  Leu Ile Asp Lys Leu  Ser Phe Leu 
        995                 1000                 1005             


Val Asp  Lys Gly Glu Lys Asn  Pro Glu Gln Ala Gly  His Leu Leu 
    1010                 1015                 1020             


Lys Ala  Tyr Gln Leu Ser Ala  Pro Phe Glu Thr Phe  Gln Lys Met 
    1025                 1030                 1035             


Gly Lys  Gln Thr Gly Ile Ile  Phe Tyr Thr Gln Ala  Ser Tyr Thr 
    1040                 1045                 1050             


Ser Lys  Ser Asp Pro Val Thr  Gly Trp Arg Pro His  Leu Tyr Leu 
    1055                 1060                 1065             


Lys Tyr  Phe Ser Ala Lys Lys  Ala Lys Asp Asp Ile  Ala Lys Phe 
    1070                 1075                 1080             


Thr Lys  Ile Glu Phe Val Asn  Asp Arg Phe Glu Leu  Thr Tyr Asp 
    1085                 1090                 1095             


Ile Lys  Asp Phe Gln Gln Ala  Lys Glu Tyr Pro Asn  Lys Thr Val 
    1100                 1105                 1110             


Trp Lys  Val Cys Ser Asn Val  Glu Arg Phe Arg Trp  Asp Lys Asn 
    1115                 1120                 1125             


Leu Asn  Gln Asn Lys Gly Gly  Tyr Thr His Tyr Thr  Asn Ile Thr 
    1130                 1135                 1140             


Glu Asn  Ile Gln Glu Leu Phe  Thr Lys Tyr Gly Ile  Asp Ile Thr 
    1145                 1150                 1155             


Lys Asp  Leu Leu Thr Gln Ile  Ser Thr Ile Asp Glu  Lys Gln Asn 
    1160                 1165                 1170             


Thr Ser  Phe Phe Arg Asp Phe  Ile Phe Tyr Phe Asn  Leu Ile Cys 
    1175                 1180                 1185             


Gln Ile  Arg Asn Thr Asp Asp  Ser Glu Ile Ala Lys  Lys Asn Gly 
    1190                 1195                 1200             


Lys Asp  Asp Phe Ile Leu Ser  Pro Val Glu Pro Phe  Phe Asp Ser 
    1205                 1210                 1215             


Arg Lys  Asp Asn Gly Asn Lys  Leu Pro Glu Asn Gly  Asp Asp Asn 
    1220                 1225                 1230             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Ile Val Ile  Leu Asn Lys 
    1235                 1240                 1245             


Ile Ser  Gln Tyr Ser Glu Lys  Asn Glu Asn Cys Glu  Lys Met Lys 
    1250                 1255                 1260             


Trp Gly  Asp Leu Tyr Val Ser  Asn Ile Asp Trp Asp  Asn Phe Val 
    1265                 1270                 1275             


Thr Gln  Ala Asn Ala Arg His  
    1280                 1285 


<210> 14
<211> 1366
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 14
Met Asn Thr Gln Lys Lys Glu Phe Asn Pro Lys Ser Phe Lys Asp Phe 
1               5                   10                  15      


Thr Asn Leu Tyr Ser Leu Asn Lys Thr Leu Arg Phe Ser Leu Thr Pro 
            20                  25                  30          


Asn Lys Lys Thr Ala Glu Ile Leu Glu Phe Asn Lys Gln Lys Glu Val 
        35                  40                  45              


Lys Cys Phe Ser Asn Asp Arg Lys Ile Ala Gly Ala Tyr Gln Glu Ile 
    50                  55                  60                  


Lys Lys Tyr Leu Asn Lys Leu His Gln Glu Phe Ile Gln Glu Ala Met 
65                  70                  75                  80  


Lys Phe Phe Ala Phe Ser Glu Glu Glu Leu Lys Gly Phe Glu Lys Glu 
                85                  90                  95      


Tyr Leu Asn Leu Leu Asn Phe Thr Asp Lys Asp Asn Phe Lys Lys Lys 
            100                 105                 110         


Asn Lys Ile Arg Asn Glu Tyr Glu Gln Glu Arg Lys Ile Leu Thr Ile 
        115                 120                 125             


Lys Ile Ala Thr Tyr Phe Ser Lys Phe Lys Ser Glu Lys Tyr Gln Ser 
    130                 135                 140                 


Phe Asn Leu Ala Asn Ile Thr Gly Lys Lys Val Phe Ser Ile Leu Glu 
145                 150                 155                 160 


Gln Lys Tyr Lys Glu Asp Lys Lys Thr Leu Lys Ile Ile His Ile Phe 
                165                 170                 175     


Lys Tyr Lys Pro Thr Lys Asp Glu Lys Lys Glu Gly Glu Ala Val Asn 
            180                 185                 190         


Phe Ser Thr Tyr Leu Thr Gly Phe Asn Glu Asn Arg Lys Asn Phe Tyr 
        195                 200                 205             


Lys Ser Glu Asp Lys Ala Gly Gln Phe Ala Thr Arg Thr Ile Asp Asn 
    210                 215                 220                 


Leu Ala Gln Phe Ile Lys Asn Lys Lys Leu Phe Glu Asp Lys Tyr Gln 
225                 230                 235                 240 


Lys Asn Tyr Ser Lys Ile Gly Ile Leu Asp Glu Gln Ile Lys Ile Phe 
                245                 250                 255     


Asn Leu Asp Tyr Phe Asn Asn Leu Phe Leu Gln Glu Gly Leu Asp Glu 
            260                 265                 270         


Tyr Asn Gly Ile Leu Gly Asn Asn Lys Gly Glu Glu Asn Lys Ser Asn 
        275                 280                 285             


Glu Gly Ile Asn Gln Lys Ile Asn Ile Phe Lys Gln Lys Glu Lys Ala 
    290                 295                 300                 


Arg Leu Lys Lys Glu Lys Glu Asn Phe Asn Lys Ser Asp Phe Pro Leu 
305                 310                 315                 320 


Phe Lys Glu Leu Tyr Lys Gln Ile Gly Ser Ile Arg Lys Glu Asn Asp 
                325                 330                 335     


Val Tyr Val Glu Ile Lys Thr Asp Lys Glu Leu Val Glu Glu Leu Asn 
            340                 345                 350         


Asn Phe Pro Lys Asn Val Glu Asn Tyr Leu Lys Asp Ile Gln Ser Phe 
        355                 360                 365             


Tyr Lys Thr Phe Phe Glu Lys Leu Gln Asn Glu Glu Tyr Glu Leu Asp 
    370                 375                 380                 


Lys Ile Tyr Leu Pro Lys Ser Val Gly Thr Tyr Phe Ser Tyr Ile Ala 
385                 390                 395                 400 


Phe Ser Asp Trp Asn Lys Leu Ala Phe Ile Tyr Asn Lys Arg Tyr Lys 
                405                 410                 415     


Asn Glu Lys Ile Lys Ile Val Glu Gly Gly Asp Val Asn Val Gln Tyr 
            420                 425                 430         


Arg Ser Leu Glu Val Leu Lys Asn Arg Ile Asp Glu Leu Lys Asp Glu 
        435                 440                 445             


Asp Asn Leu Asn Phe Asn Lys Phe Phe Ile Asp Lys Leu Lys Phe Asn 
    450                 455                 460                 


Glu Ala Lys Lys Glu Asn Asn Trp Gln Asn Phe Trp Phe Cys Ile Glu 
465                 470                 475                 480 


Tyr Tyr Ile Asn Ser Gln Phe Ile Gly Gly Glu Lys Asn Ile Leu Asn 
                485                 490                 495     


Lys Glu Lys Asn Glu Tyr Glu Ile Leu Pro Phe Gly Ser Leu Lys Glu 
            500                 505                 510         


Leu Lys Glu Lys Tyr Phe Glu Ala Val Lys Lys Tyr Lys Glu Lys Met 
        515                 520                 525             


Val Asp Thr Glu Ser Gly Leu Thr Asp Asp Glu Glu Lys Glu Ile Lys 
    530                 535                 540                 


Glu Thr Leu Lys Asn Tyr Leu Asp Arg Ile Lys Glu Ile Glu Arg Ile 
545                 550                 555                 560 


Ala Lys Tyr Phe Asp Leu Lys Lys Ser Phe Glu Glu Ile Lys Gln Glu 
                565                 570                 575     


Asp Leu Asp Ser Asn Phe Tyr Gly Glu Tyr Gln Lys Val Val Asp Lys 
            580                 585                 590         


Thr Asn Glu Leu Lys Ile Tyr Gln Tyr Tyr Ser Glu Phe Arg Asn Tyr 
        595                 600                 605             


Leu Thr Gln Asn Asn Ser Val Glu Glu Lys Ile Lys Leu Asn Phe Asn 
    610                 615                 620                 


Ser Gly Leu Leu Leu Asp Gly Trp Asp Leu Asn Lys Glu Lys Val Lys 
625                 630                 635                 640 


Phe Ser Ile Ile Phe Gln Glu Asn Gly Lys Tyr Tyr Leu Gly Ile Ile 
                645                 650                 655     


Asn Lys Glu Lys Asp Lys Thr Ile Leu Asp Lys Asp Lys His Pro Glu 
            660                 665                 670         


Ile Phe Thr Lys Asn Ser Asp Phe Arg Lys Met Glu Tyr Lys Leu Phe 
        675                 680                 685             


Pro Ser Pro Ser Lys Met Leu Pro Lys Ile Ser Phe Ser Glu Thr Ala 
    690                 695                 700                 


Lys Lys Gly Asp Glu Asp Val Gly Trp Ser Glu Glu Ile Gln Lys Ile 
705                 710                 715                 720 


Lys Asp Glu Phe Ala Glu Phe Gln Glu Tyr Lys Lys Lys Ser Lys Asp 
                725                 730                 735     


Asn Trp Lys Asp Glu Phe Asn Arg Gly Lys Leu Asn Lys Leu Ile Asp 
            740                 745                 750         


Tyr Tyr Lys Gln Val Leu Glu Lys His Ser Glu Gly Tyr Met Asn Thr 
        755                 760                 765             


Tyr Asn Phe Glu Leu Lys Asp Ser Ser Lys Tyr Lys Asn Leu Gly Glu 
    770                 775                 780                 


Phe Asn Asp Asp Ile Ala Arg Gln Asn Tyr Lys Val Lys Phe Val Gly 
785                 790                 795                 800 


Ile Asp Lys Asn Tyr Ile Asp Glu Lys Val Ala Asn Gly Glu Leu Phe 
                805                 810                 815     


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Asp Lys Lys Glu Gly 
            820                 825                 830         


Ser Thr Asn Asn Leu Glu Thr Ile Tyr Phe Lys Glu Leu Phe Ser Lys 
        835                 840                 845             


Glu Asn Leu Glu Asn Pro Val Phe Lys Leu Ser Gly Gly Ala Glu Met 
    850                 855                 860                 


Phe Phe Arg Asn Lys Ile Glu Lys Lys Lys Glu Lys Lys Lys Leu Asp 
865                 870                 875                 880 


Lys Asp Gly Lys Pro Met Ile Ser Lys Lys Gly Glu Lys Val Val Asp 
                885                 890                 895     


Lys Arg Arg Phe Ser Glu Asn Lys Ile Leu Phe His Leu Pro Ile Glu 
            900                 905                 910         


Ile Asn Tyr Gly Lys Gly Lys Met Pro Asn Phe Asn Lys Lys Ile Asn 
        915                 920                 925             


Glu Tyr Ile Ser Lys Asn Pro Glu Asn Ile Lys Ile Ile Gly Ile Asp 
    930                 935                 940                 


Arg Gly Glu Lys His Leu Leu Tyr Tyr Ser Ile Ile Asp Gln Asn Gly 
945                 950                 955                 960 


Asn Asn Ile Glu Ser Met Ser Leu Asn Ala Val Asp Glu Phe Gly Asn 
                965                 970                 975     


Phe Val Asn Pro Glu Lys Leu Glu Glu Tyr Glu Ile Asp Asn Asn Gly 
            980                 985                 990         


Lys Lys Glu Arg Arg Trp Lys Tyr  Ile Val Asn Asp Lys  Glu Ile Lys 
        995                 1000                 1005             


Val Thr  Asn Tyr Gln Arg Lys  Leu Asp Glu Leu Glu  Lys Glu Arg 
    1010                 1015                 1020             


Gln Lys  Ser Arg Gln Ser Trp  Gln Asn Ile Asn Lys  Ile Lys Asn 
    1025                 1030                 1035             


Leu Lys  Lys Gly Tyr Ile Ser  Phe Val Val Lys Lys  Ile Val Asp 
    1040                 1045                 1050             


Leu Ala  Ile Glu Asn Asn Ala  Ile Ile Ile Leu Glu  Asp Leu Asn 
    1055                 1060                 1065             


Phe Gly  Phe Lys Ser Phe Arg  Gln Lys Ile Glu Lys  Asn Val Tyr 
    1070                 1075                 1080             


Gln Gln  Phe Glu Lys Ala Leu  Ile Asp Lys Leu Gly  Phe Val Val 
    1085                 1090                 1095             


Asp Lys  Gln Lys Gln Asn Gln  Arg Phe Ala Pro Gln  Leu Ser Ala 
    1100                 1105                 1110             


Pro Phe  Glu Ser Phe Gln Lys  Ile Gly Lys Gln Thr  Gly Ile Val 
    1115                 1120                 1125             


Tyr Tyr  Val Leu Ala Asn Asn  Thr Ser Lys Val Cys  Pro Ser Cys 
    1130                 1135                 1140             


Gln Trp  Ile Lys Asn Phe Tyr  Leu Lys Tyr Glu Lys  Lys Asn Thr 
    1145                 1150                 1155             


Ile Phe  Asn Leu Gln Lys Asn  Gln Lys Leu Lys Val  Phe Phe Glu 
    1160                 1165                 1170             


Gln Glu  Lys Asn Arg Phe Arg  Phe Glu Tyr Gln Met  Ser Lys Glu 
    1175                 1180                 1185             


Tyr Ile  Ser Val Tyr Ser Asp  Val Asp Arg Gln Arg  Tyr Asp Lys 
    1190                 1195                 1200             


Thr Lys  Asn Gln Asn Lys Gly  Gly Tyr Leu Glu Tyr  Lys Asn Ser 
    1205                 1210                 1215             


Asn Gln  Lys Glu Ile Ile Asp  Lys Asp Gly Val Ile  Gln Lys Gln 
    1220                 1225                 1230             


Ser Ile  Thr Leu Gln Leu Lys  Glu Leu Phe Lys Glu  Asn His Ile 
    1235                 1240                 1245             


Asp Leu  Glu Lys Glu Ile Leu  Lys Gln Leu Asp Asn  Lys Lys Glu 
    1250                 1255                 1260             


Lys Asn  Ser Gly Tyr Thr Gly  Val Tyr Asn Lys Phe  Ile Tyr Leu 
    1265                 1270                 1275             


Phe Asn  Leu Ile Leu Gln Ile  Arg Asn Ala Ile Ser  Phe Arg Glu 
    1280                 1285                 1290             


Lys Asp  Tyr Ile Gln Cys Pro  Ser Cys His Phe Asp  Thr Arg Lys 
    1295                 1300                 1305             


Glu Asn  Tyr Leu Lys Ile Asn  Asp Gly Asp Gly Asn  Gly Ala Tyr 
    1310                 1315                 1320             


Asn Ile  Ala Leu Arg Gly Leu  Tyr Leu Leu Lys Gly  Lys Asn Gly 
    1325                 1330                 1335             


Ile Ile  Asn Asn Leu Glu Lys  Ile Lys Leu Ile Phe  Ser Asn Asn 
    1340                 1345                 1350             


Asp Tyr  Phe Gln Trp Ala Lys  Lys Leu Lys Asn Lys  Lys 
    1355                 1360                 1365     


<210> 15
<211> 1285
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 15
Met Glu Glu Lys Met Leu Lys Ser Tyr Asp Tyr Phe Thr Lys Leu Tyr 
1               5                   10                  15      


Ser Leu Gln Lys Thr Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr 
            20                  25                  30          


Leu Glu His Ile Lys Asn Ser Gly Ile Ile Glu Ser Asp Glu Thr Leu 
        35                  40                  45              


Glu Glu Gln Tyr Ala Ile Val Lys Asn Ile Ile Asp Lys Leu His Arg 
    50                  55                  60                  


Lys His Ile Asp Glu Ala Leu Ser Leu Val Asp Phe Thr Lys His Leu 
65                  70                  75                  80  


Asp Thr Leu Lys Thr Phe Gln Glu Leu Tyr Leu Lys Arg Gly Lys Thr 
                85                  90                  95      


Asp Lys Glu Lys Glu Glu Leu Glu Lys Leu Ser Ala Asp Leu Arg Lys 
            100                 105                 110         


Leu Ile Val Ser Tyr Leu Lys Gly Asn Val Lys Glu Lys Thr Gln His 
        115                 120                 125             


Asn Leu Asn Pro Ile Lys Glu Arg Phe Glu Ile Leu Phe Gly Lys Glu 
    130                 135                 140                 


Leu Phe Thr Asn Glu Glu Phe Phe Leu Leu Ala Glu Asn Glu Lys Glu 
145                 150                 155                 160 


Lys Lys Ala Ile Gln Ala Phe Lys Gly Phe Thr Thr Tyr Phe Lys Gly 
                165                 170                 175     


Phe Gln Glu Asn Arg Lys Asn Met Tyr Ser Glu Glu Gly Asn Ser Thr 
            180                 185                 190         


Ser Ile Ala Tyr Arg Ile Ile Asn Glu Asn Leu Pro Leu Phe Ile Glu 
        195                 200                 205             


Asn Ile Ala Arg Phe Gln Lys Val Met Ser Thr Ile Glu Lys Thr Thr 
    210                 215                 220                 


Ile Lys Lys Leu Glu Gln Asn Leu Lys Thr Glu Leu Lys Lys His Asn 
225                 230                 235                 240 


Leu Pro Gly Ile Phe Thr Ile Glu Tyr Phe Asn Asn Val Leu Thr Gln 
                245                 250                 255     


Glu Gly Ile Ser Arg Tyr Asn Thr Ile Ile Gly Gly Lys Thr Thr His 
            260                 265                 270         


Glu Gly Val Lys Ile Gln Gly Leu Asn Glu Ile Ile Asn Leu Tyr Asn 
        275                 280                 285             


Gln Gln Ser Lys Asp Val Lys Leu Pro Ile Leu Lys Pro Leu His Lys 
    290                 295                 300                 


Gln Ile Leu Ser Glu Glu Tyr Ser Thr Ser Phe Lys Ile Lys Ala Phe 
305                 310                 315                 320 


Glu Asn Asp Asn Glu Val Leu Lys Ala Ile Asp Thr Phe Trp Asn Glu 
                325                 330                 335     


His Ile Glu Lys Ser Ile His Pro Val Thr Gly Asn Lys Phe Asn Ile 
            340                 345                 350         


Leu Ser Lys Ile Glu Asn Leu Cys Asp Gln Leu Gln Lys Tyr Lys Asp 
        355                 360                 365             


Lys Asp Leu Glu Lys Leu Phe Ile Glu Arg Lys Asn Leu Ser Thr Val 
    370                 375                 380                 


Ser His Gln Val Tyr Gly Gln Trp Asn Ile Ile Arg Asp Ala Leu Arg 
385                 390                 395                 400 


Met His Leu Glu Met Asn Asn Lys Asn Ile Lys Glu Lys Asp Ile Asp 
                405                 410                 415     


Lys Tyr Leu Asp Asn Asp Ala Phe Ser Trp Lys Glu Ile Lys Asp Ser 
            420                 425                 430         


Ile Lys Ile Tyr Lys Glu His Val Glu Asp Ala Lys Glu Leu Asn Glu 
        435                 440                 445             


Asn Gly Ile Ile Lys Tyr Phe Ser Ala Met Ser Ile Asn Glu Glu Asp 
    450                 455                 460                 


Asp Glu Lys Glu Tyr Ser Ile Ser Leu Ile Lys Asn Ile Asn Glu Lys 
465                 470                 475                 480 


Tyr Asn Asn Val Lys Ser Ile Leu Gln Glu Asp Arg Thr Gly Lys Ser 
                485                 490                 495     


Asp Leu His Gln Asp Lys Glu Lys Val Gly Ile Ile Lys Glu Phe Leu 
            500                 505                 510         


Asp Ser Leu Lys Gln Leu Gln Trp Phe Leu Arg Leu Leu Tyr Val Thr 
        515                 520                 525             


Val Pro Leu Asp Glu Lys Asp Tyr Glu Phe Tyr Asn Glu Leu Glu Val 
    530                 535                 540                 


Tyr Tyr Glu Ala Leu Leu Pro Leu Asn Ser Leu Tyr Asn Lys Val Arg 
545                 550                 555                 560 


Asn Tyr Met Thr Arg Lys Pro Tyr Ser Val Glu Lys Phe Lys Leu Asn 
                565                 570                 575     


Phe Asn Ser Pro Thr Leu Leu Asp Gly Trp Asp Lys Asn Lys Glu Thr 
            580                 585                 590         


Ala Asn Leu Ser Ile Ile Leu Arg Lys Asn Gly Lys Tyr Tyr Leu Gly 
        595                 600                 605             


Ile Met Asn Lys Glu Asn Asn Thr Ile Phe Glu Tyr Tyr Pro Gly Thr 
    610                 615                 620                 


Lys Ser Asn Asp Tyr Tyr Glu Lys Met Ile Tyr Lys Leu Leu Pro Gly 
625                 630                 635                 640 


Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Gly Leu Glu 
                645                 650                 655     


Tyr Tyr Asn Pro Pro Lys Glu Ile Leu Asn Ile Tyr Glu Lys Gly Glu 
            660                 665                 670         


Phe Lys Lys Asp Lys Ser Gly Asn Phe Lys Lys Glu Ser Leu His Thr 
        675                 680                 685             


Leu Ile Asp Phe Tyr Lys Glu Ala Ile Ala Lys Asn Glu Asp Trp Glu 
    690                 695                 700                 


Val Phe Asn Phe Lys Phe Lys Asn Thr Lys Glu Tyr Glu Asp Ile Ser 
705                 710                 715                 720 


Gln Phe Tyr Arg Asp Val Glu Glu Gln Gly Tyr Leu Ile Thr Phe Glu 
                725                 730                 735     


Lys Val Asp Ala Asn Tyr Val Asp Lys Leu Val Lys Glu Gly Lys Leu 
            740                 745                 750         


Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Asn Lys Lys Ser 
        755                 760                 765             


Lys Gly Asn Pro Asn Leu His Thr Ile Tyr Trp Lys Gly Leu Tyr Asp 
    770                 775                 780                 


Ser Glu Asn Leu Lys Asn Val Val Tyr Lys Leu Asn Gly Glu Ala Glu 
785                 790                 795                 800 


Val Phe Tyr Arg Lys Lys Ser Ile Asp Tyr Pro Glu Glu Ile Tyr Asn 
                805                 810                 815     


His Gly His His Lys Glu Glu Leu Leu Gly Lys Phe Asn Tyr Pro Ile 
            820                 825                 830         


Ile Lys Asp Arg Arg Tyr Thr Gln Asp Lys Phe Leu Phe His Val Pro 
        835                 840                 845             


Ile Thr Met Asn Phe Ile Ser Lys Glu Glu Lys Arg Val Asn Gln Leu 
    850                 855                 860                 


Ala Cys Glu Tyr Leu Ser Ala Thr Lys Glu Asp Val His Ile Ile Gly 
865                 870                 875                 880 


Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Ser Leu Ile Asp Lys 
                885                 890                 895     


Glu Gly Asn Ile Lys Lys Gln Leu Ser Leu Asn Thr Ile Lys Asn Glu 
            900                 905                 910         


Asn Tyr Asp Lys Glu Ile Asp Tyr Arg Val Lys Leu Asp Glu Lys Glu 
        915                 920                 925             


Lys Lys Arg Asp Glu Ala Arg Lys Asn Trp Asp Val Ile Glu Asn Ile 
    930                 935                 940                 


Lys Glu Leu Lys Glu Gly Tyr Met Ser Gln Val Ile His Ile Ile Ala 
945                 950                 955                 960 


Lys Met Met Val Glu Glu Lys Ala Ile Leu Ile Met Glu Asp Leu Asn 
                965                 970                 975     


Ile Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln Val Tyr Gln 
            980                 985                 990         


Lys Phe Glu Lys Met Leu Ile Asp  Lys Leu Asn Tyr Leu  Val Phe Lys 
        995                 1000                 1005             


Asn Lys  Asn Pro Leu Glu Pro  Gly Gly Ser Leu Asn  Ala Tyr Gln 
    1010                 1015                 1020             


Leu Thr  Ser Lys Phe Asp Ser  Phe Lys Lys Leu Gly  Lys Gln Ser 
    1025                 1030                 1035             


Gly Phe  Ile Phe Tyr Val Pro  Ser Ala Tyr Thr Ser  Lys Ile Asp 
    1040                 1045                 1050             


Pro Thr  Thr Gly Phe Tyr Asn  Phe Ile Gln Val Asp  Val Pro Asn 
    1055                 1060                 1065             


Leu Glu  Lys Gly Lys Glu Phe  Phe Ser Lys Phe Glu  Lys Ile Ile 
    1070                 1075                 1080             


Tyr Asn  Thr Lys Glu Asp Tyr  Phe Glu Phe His Cys  Lys Tyr Gly 
    1085                 1090                 1095             


Lys Phe  Val Ser Glu Pro Lys  Asn Lys Asp Asn Asp  Arg Lys Thr 
    1100                 1105                 1110             


Lys Glu  Ser Leu Thr Tyr Tyr  Asn Ala Ile Lys Asp  Thr Val Trp 
    1115                 1120                 1125             


Val Val  Cys Ser Thr Asn His  Glu Arg Tyr Lys Ile  Val Arg Asn 
    1130                 1135                 1140             


Lys Ala  Gly Tyr Tyr Glu Ser  His Pro Val Asp Val  Thr Lys Asn 
    1145                 1150                 1155             


Leu Lys  Asp Ile Phe Ser Gln  Ala Asn Ile Asn Tyr  Asn Glu Gly 
    1160                 1165                 1170             


Lys Asp  Ile Lys Pro Ile Ile  Ile Glu Ser Asn Asn  Ala Lys Leu 
    1175                 1180                 1185             


Leu Lys  Ser Ile Ala Glu Gln  Leu Lys Leu Ile Leu  Ala Met Arg 
    1190                 1195                 1200             


Tyr Asn  Asn Gly Lys His Gly  Asp Asp Glu Lys Asp  Tyr Ile Leu 
    1205                 1210                 1215             


Ser Pro  Val Lys Asn Lys Gln  Gly Lys Phe Phe Cys  Thr Leu Asp 
    1220                 1225                 1230             


Gly Asn  Gln Thr Leu Pro Ile  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1235                 1240                 1245             


Asn Ile  Ala Leu Lys Gly Leu  Leu Leu Ile Glu Lys  Ile Lys Lys 
    1250                 1255                 1260             


Gln Gln  Gly Lys Ile Lys Asp  Leu Tyr Ile Ser Asn  Leu Glu Trp 
    1265                 1270                 1275             


Phe Met  Phe Met Met Ser Arg  
    1280                 1285 


<210> 16
<211> 1238
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 16
Met Asn Asn Tyr Asp Glu Phe Thr Lys Leu Tyr Pro Ile Gln Lys Thr 
1               5                   10                  15      


Ile Arg Phe Glu Leu Lys Pro Gln Gly Arg Thr Met Glu His Leu Glu 
            20                  25                  30          


Thr Phe Asn Phe Phe Glu Glu Asp Arg Asp Arg Ala Glu Lys Tyr Lys 
        35                  40                  45              


Ile Leu Lys Glu Ala Ile Asp Glu Tyr His Lys Lys Phe Ile Asp Glu 
    50                  55                  60                  


His Leu Thr Asn Met Ser Leu Asp Trp Asn Ser Leu Lys Gln Ile Ser 
65                  70                  75                  80  


Glu Lys Tyr Tyr Lys Ser Arg Glu Glu Lys Asp Lys Lys Val Phe Leu 
                85                  90                  95      


Ser Glu Gln Lys Arg Met Arg Gln Glu Ile Val Ser Glu Phe Lys Lys 
            100                 105                 110         


Asp Asp Arg Phe Lys Asp Leu Phe Ser Lys Lys Leu Phe Ser Glu Leu 
        115                 120                 125             


Leu Lys Glu Glu Ile Tyr Lys Lys Gly Asn His Gln Glu Ile Asp Ala 
    130                 135                 140                 


Leu Lys Ser Phe Asp Lys Phe Ser Gly Tyr Phe Ile Gly Leu His Glu 
145                 150                 155                 160 


Asn Arg Lys Asn Met Tyr Ser Asp Gly Asp Glu Ile Thr Ala Ile Ser 
                165                 170                 175     


Asn Arg Ile Val Asn Glu Asn Phe Pro Lys Phe Leu Asp Asn Leu Gln 
            180                 185                 190         


Lys Tyr Gln Glu Ala Arg Lys Lys Tyr Pro Glu Trp Ile Ile Lys Ala 
        195                 200                 205             


Glu Ser Ala Leu Val Ala His Asn Ile Lys Met Asp Glu Val Phe Ser 
    210                 215                 220                 


Leu Glu Tyr Phe Asn Lys Val Leu Asn Gln Glu Gly Ile Gln Arg Tyr 
225                 230                 235                 240 


Asn Leu Ala Leu Gly Gly Tyr Val Thr Lys Ser Gly Glu Lys Met Met 
                245                 250                 255     


Gly Leu Asn Asp Ala Leu Asn Leu Ala His Gln Ser Glu Lys Ser Ser 
            260                 265                 270         


Lys Gly Arg Ile His Met Thr Pro Leu Phe Lys Gln Ile Leu Ser Glu 
        275                 280                 285             


Lys Glu Ser Phe Ser Tyr Ile Pro Asp Val Phe Thr Glu Asp Ser Gln 
    290                 295                 300                 


Leu Leu Pro Ser Ile Gly Gly Phe Phe Ala Gln Ile Glu Asn Asp Lys 
305                 310                 315                 320 


Asp Gly Asn Ile Phe Asp Arg Ala Leu Glu Leu Ile Ser Ser Tyr Ala 
                325                 330                 335     


Glu Tyr Asp Thr Glu Arg Ile Tyr Ile Arg Gln Ala Asp Ile Asn Arg 
            340                 345                 350         


Val Ser Asn Val Ile Phe Gly Glu Trp Gly Thr Leu Gly Gly Leu Met 
        355                 360                 365             


Arg Glu Tyr Lys Ala Asp Ser Ile Asn Asp Ile Asn Leu Glu Arg Thr 
    370                 375                 380                 


Cys Lys Lys Val Asp Lys Trp Leu Asp Ser Lys Glu Phe Ala Leu Ser 
385                 390                 395                 400 


Asp Val Leu Glu Ala Ile Lys Arg Thr Gly Asn Asn Asp Ala Phe Asn 
                405                 410                 415     


Glu Tyr Ile Ser Lys Met Arg Thr Ala Arg Glu Lys Ile Asp Ala Ala 
            420                 425                 430         


Arg Lys Glu Met Lys Phe Ile Ser Glu Lys Ile Ser Gly Asp Glu Glu 
        435                 440                 445             


Ser Ile His Ile Ile Lys Thr Leu Leu Asp Ser Val Gln Gln Phe Leu 
    450                 455                 460                 


His Phe Phe Asn Leu Phe Lys Ala Arg Gln Asp Ile Pro Leu Asp Gly 
465                 470                 475                 480 


Ala Phe Tyr Ala Glu Phe Asp Glu Val His Ser Lys Leu Phe Ala Ile 
                485                 490                 495     


Val Pro Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Lys Asn Asn Leu 
            500                 505                 510         


Asn Thr Lys Lys Ile Lys Leu Asn Phe Lys Asn Pro Thr Leu Ala Asn 
        515                 520                 525             


Gly Trp Asp Gln Asn Lys Val Tyr Asp Tyr Ala Ser Leu Ile Phe Leu 
    530                 535                 540                 


Arg Asp Gly Asn Tyr Tyr Leu Gly Ile Ile Asn Pro Lys Arg Lys Lys 
545                 550                 555                 560 


Asn Ile Lys Phe Glu Gln Gly Ser Gly Asn Gly Pro Phe Tyr Arg Lys 
                565                 570                 575     


Met Val Tyr Lys Gln Ile Pro Gly Pro Asn Lys Asn Leu Pro Arg Val 
            580                 585                 590         


Phe Leu Thr Ser Thr Lys Gly Lys Lys Glu Tyr Lys Pro Ser Lys Glu 
        595                 600                 605             


Ile Ile Glu Gly Tyr Glu Ala Asp Lys His Ile Arg Gly Asp Lys Phe 
    610                 615                 620                 


Asp Leu Asp Phe Cys His Lys Leu Ile Asp Phe Phe Lys Glu Ser Ile 
625                 630                 635                 640 


Glu Lys His Lys Asp Trp Ser Lys Phe Asn Phe Tyr Phe Ser Pro Thr 
                645                 650                 655     


Glu Ser Tyr Gly Asp Ile Ser Glu Phe Tyr Leu Asp Val Glu Lys Gln 
            660                 665                 670         


Gly Tyr Arg Met His Phe Glu Asn Ile Ser Ala Glu Thr Ile Asp Glu 
        675                 680                 685             


Tyr Val Glu Lys Gly Asp Leu Phe Leu Phe Gln Ile Tyr Asn Lys Asp 
    690                 695                 700                 


Phe Val Lys Ala Ala Thr Gly Lys Lys Asp Met His Thr Ile Tyr Trp 
705                 710                 715                 720 


Asn Ala Ala Phe Ser Pro Glu Asn Leu Gln Asp Val Val Val Lys Leu 
                725                 730                 735     


Asn Gly Glu Ala Glu Leu Phe Tyr Arg Asp Lys Ser Asp Ile Lys Glu 
            740                 745                 750         


Ile Val His Arg Glu Gly Glu Ile Leu Val Asn Arg Thr Tyr Asn Gly 
        755                 760                 765             


Arg Thr Pro Val Pro Asp Lys Ile His Lys Lys Leu Thr Asp Tyr His 
    770                 775                 780                 


Asn Gly Arg Thr Lys Asp Leu Gly Glu Ala Lys Glu Tyr Leu Asp Lys 
785                 790                 795                 800 


Val Arg Tyr Phe Lys Ala His Tyr Asp Ile Thr Lys Asp Arg Arg Tyr 
                805                 810                 815     


Leu Asn Asp Lys Ile Tyr Phe His Val Pro Leu Thr Leu Asn Phe Lys 
            820                 825                 830         


Ala Asn Gly Lys Lys Asn Leu Asn Lys Met Val Ile Glu Lys Phe Leu 
        835                 840                 845             


Ser Asp Glu Lys Ala His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn 
    850                 855                 860                 


Leu Leu Tyr Tyr Ser Ile Ile Asp Arg Ser Gly Lys Ile Ile Asp Gln 
865                 870                 875                 880 


Gln Ser Leu Asn Val Ile Asp Gly Phe Asp Tyr Arg Glu Lys Leu Asn 
                885                 890                 895     


Gln Arg Glu Ile Glu Met Lys Asp Ala Arg Gln Ser Trp Asn Ala Ile 
            900                 905                 910         


Gly Lys Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ser Lys Ala Val His 
        915                 920                 925             


Glu Ile Thr Lys Met Ala Ile Gln Tyr Asn Ala Ile Val Val Met Glu 
    930                 935                 940                 


Glu Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln 
945                 950                 955                 960 


Ile Tyr Gln Lys Phe Glu Asn Met Leu Ile Asp Lys Met Asn Tyr Leu 
                965                 970                 975     


Val Phe Lys Asp Ala Pro Asp Glu Ser Pro Gly Gly Val Leu Asn Ala 
            980                 985                 990         


Tyr Gln Leu Thr Asn Pro Leu Glu  Ser Phe Ala Lys Leu  Gly Lys Gln 
        995                 1000                 1005             


Thr Gly  Ile Leu Phe Tyr Val  Pro Ala Ala Tyr Thr  Ser Lys Ile 
    1010                 1015                 1020             


Asp Pro  Thr Thr Gly Phe Val  Asn Leu Phe Asn Thr  Ser Ser Lys 
    1025                 1030                 1035             


Thr Asn  Ala Gln Glu Arg Lys  Glu Phe Leu Gln Lys  Phe Glu Ser 
    1040                 1045                 1050             


Ile Ser  Tyr Ser Ala Lys Asp  Gly Gly Ile Phe Ala  Phe Ala Phe 
    1055                 1060                 1065             


Asp Tyr  Arg Lys Phe Gly Thr  Ser Lys Thr Asp His  Lys Asn Val 
    1070                 1075                 1080             


Trp Thr  Ala Tyr Thr Asn Gly  Glu Arg Met Arg Tyr  Ile Lys Glu 
    1085                 1090                 1095             


Lys Lys  Arg Asn Glu Leu Phe  Asp Pro Ser Lys Glu  Ile Lys Glu 
    1100                 1105                 1110             


Ala Leu  Thr Ser Ser Gly Ile  Lys Tyr Asp Gly Gly  Gln Asn Ile 
    1115                 1120                 1125             


Leu Pro  Asp Ile Leu Arg Ser  Asn Asn Asn Gly Leu  Ile Tyr Thr 
    1130                 1135                 1140             


Met Tyr  Ser Ser Phe Ile Ala  Ala Ile Gln Met Arg  Val Tyr Asp 
    1145                 1150                 1155             


Gly Lys  Glu Asp Tyr Ile Ile  Ser Pro Ile Lys Asn  Ser Lys Gly 
    1160                 1165                 1170             


Glu Phe  Phe Arg Thr Asp Pro  Lys Arg Arg Glu Leu  Pro Ile Asp 
    1175                 1180                 1185             


Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala Leu Arg  Gly Glu Leu 
    1190                 1195                 1200             


Thr Met  Arg Ala Ile Ala Glu  Lys Phe Asp Pro Asp  Ser Glu Lys 
    1205                 1210                 1215             


Met Ala  Lys Leu Glu Leu Lys  His Lys Asp Trp Phe  Glu Phe Met 
    1220                 1225                 1230             


Gln Thr  Arg Gly Asp 
    1235             


<210> 17
<211> 1347
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 17
Met Ala Ser Ser His Phe Ile Ser Leu Asp Asn Ser Phe Ser Lys Phe 
1               5                   10                  15      


Thr Asn Leu Tyr Ser Leu Ser Lys Thr Leu Arg Phe Glu Leu Val Pro 
            20                  25                  30          


Thr Glu Asn Thr Thr Val Met Leu Glu Asn Asn Asn Val Phe Lys Lys 
        35                  40                  45              


Asp Gln Ile Ile Gln Val Lys Tyr Glu Lys Thr Lys Pro Phe Ile Asp 
    50                  55                  60                  


Arg Leu His Arg Glu Phe Ile Lys Glu Ala Leu Ser Asn Tyr Ala Val 
65                  70                  75                  80  


Ser Gly Leu Gln Glu Tyr Phe Glu Ile Leu Arg Ala Gly Gly Lys Lys 
                85                  90                  95      


Ala Asn Leu Asp Ser Ala Lys Lys Gln Leu Arg Lys His Val Val Asp 
            100                 105                 110         


Gln Phe Asn Ala Thr Ala Ser Leu Trp Val Ser Arg His Lys Asp Val 
        115                 120                 125             


Gly Phe Lys Gly Glu Gly Ile Glu Leu Leu Phe Lys Glu Ala Val Phe 
    130                 135                 140                 


Lys Leu Leu Lys Glu Lys Tyr Gly Thr Asp Met Asn Ala Leu Ile Glu 
145                 150                 155                 160 


Asp Asn His Gly Lys Gln Ile Ser Ile Phe Asp Ser Trp Lys Gly Phe 
                165                 170                 175     


Thr Gly Tyr Phe Asp Lys Phe Gln Gln Thr Arg Arg Asn Leu Tyr Lys 
            180                 185                 190         


Asp Asp Gly Lys Glu Gly Arg Val Ala Thr Arg Ile Ile Asp Gln Asn 
        195                 200                 205             


Leu Thr Arg Phe Cys Asp Asn Ile Phe Val Tyr Glu Lys Ile Lys Asp 
    210                 215                 220                 


Lys Val Ser Phe Ile Asp Val Glu Lys Ser Phe Gly Lys Thr Cys Ser 
225                 230                 235                 240 


Glu Val Phe Ile Pro Asp Tyr Tyr Asn Thr Cys Leu Leu Gln Asp Gly 
                245                 250                 255     


Ile Asp Ser Tyr Asn Glu Phe Ile Gly Gly Lys Pro Leu Glu Asn Gly 
            260                 265                 270         


Glu Lys Val Gln Gly Leu Asn Glu Leu Ile Asn Leu Tyr Arg Gln Thr 
        275                 280                 285             


Thr Gly Asp Lys Val Pro Tyr Phe Lys Lys Leu Glu Lys Gln Ile Leu 
    290                 295                 300                 


Gly Glu Lys Asp Glu Val Phe Ile Asp Glu Ile Thr Asp Glu Asp Phe 
305                 310                 315                 320 


Val Pro Arg Val Leu Ala Phe Tyr Arg Thr Val Asp Ala Lys Tyr Lys 
                325                 330                 335     


Leu Phe Leu Lys Leu Leu Asp Asp Phe Val Thr Asn Gln Asp Val Tyr 
            340                 345                 350         


Glu Leu Ser Gln Ile Tyr Ile Ser Lys Lys Gly Leu Gln Glu Lys Leu 
        355                 360                 365             


Tyr Arg Trp Leu Thr Pro Ser Ala Arg Glu Val Tyr Asp Glu Glu Leu 
    370                 375                 380                 


Phe Glu Val Leu Lys Lys Ala Lys Lys Val Asn Asn Lys Asp Lys Gln 
385                 390                 395                 400 


Lys Val Ser Gly Tyr Val Pro Asp Phe Val Glu Val Leu Tyr Ile Lys 
                405                 410                 415     


Gln Ala Leu Glu Asn Ile Asp Ala Lys Leu Ile Trp Ser Asp Arg Tyr 
            420                 425                 430         


Tyr Ser Asp Gly Glu Asn Glu Gly Ile Ile Asp Lys Gly Phe Ser Ser 
        435                 440                 445             


Trp Lys Gln Phe Leu Val Ile Leu Asn His Glu Tyr Arg Gln Leu Leu 
    450                 455                 460                 


Ser Phe Glu Asp His Val Ile Ile Asp Lys Glu Leu Asp Phe Asp Lys 
465                 470                 475                 480 


Glu Val Lys Gln Leu Thr Asp Thr Val Glu Ile Val Ser Gln Asp Lys 
                485                 490                 495     


Asn Ala Arg Thr Val Thr Tyr Arg Gly Gly Tyr Asp Val Tyr Lys Ala 
            500                 505                 510         


Lys Leu Ala Glu Leu Gly Gln Ser Phe Glu Lys Asp Thr Cys Thr Lys 
        515                 520                 525             


Lys Val Ile Lys Asn Phe Ala Asp Ser Val Leu Ser Met Tyr His Phe 
    530                 535                 540                 


Ala Met Met Phe Ala Val Trp Asp Asp Thr Tyr Pro Leu Asp Val Phe 
545                 550                 555                 560 


Tyr Thr Asn Asn Glu Phe Gly Tyr Leu Leu Tyr Tyr Glu Asp Ala Tyr 
                565                 570                 575     


Lys Asn Ile Val Gln Glu Tyr Asn Lys Leu Arg Asn Tyr Leu Thr Lys 
            580                 585                 590         


Lys Pro Tyr Ser Thr Glu Lys Trp Lys Leu Asn Phe Glu Asn Pro Thr 
        595                 600                 605             


Leu Ala Ala Gly Phe Asp Lys Asn Lys Glu Ser Asp Asn Ser Thr Val 
    610                 615                 620                 


Ile Leu Arg Gln Gly Asp Lys Tyr Phe Leu Gly Val Met Lys Lys Gly 
625                 630                 635                 640 


Phe Asn Lys Ile Phe Asp Asn Ser Gln Ile Ser Gln Thr Gly Asn Ser 
                645                 650                 655     


Pro Glu Ala Tyr Phe Glu Lys Met Val Tyr Lys Tyr Thr Lys Asp Val 
            660                 665                 670         


Val Thr Gly Ile Pro Lys Ser Ser Thr Gln Val Lys Glu Val Gln Glu 
        675                 680                 685             


His Phe Arg Asn Ser Asp Glu Asp Phe Phe Leu Glu Glu Cys Ser Ser 
    690                 695                 700                 


Val Gly Asn Phe Ile Val Pro Leu Lys Ile Thr Lys Glu Ile Phe Asp 
705                 710                 715                 720 


Leu Asn Asn Lys Val Tyr Ala Lys Glu Asp Ile Ser Gln Ala Met Tyr 
                725                 730                 735     


Arg Trp Ala Leu Asn Thr Asp Glu Glu Lys Asn Tyr Val Lys Ser Phe 
            740                 745                 750         


Gln Lys Ser Tyr Leu Ser Leu Gly Gly Ser Pro Glu Leu Tyr Cys Lys 
        755                 760                 765             


Ser Val Thr Leu Trp Ile Gly Phe Cys Leu Asn Phe Leu Lys Ser Tyr 
    770                 775                 780                 


Pro Ser Ala Ala Tyr Phe Asp Tyr Ser Gln Leu Arg Gln Ala Ser Asp 
785                 790                 795                 800 


Tyr Glu Ser Val Asp Glu Cys Tyr Gln Glu Leu Asn Asn Ala Gly Tyr 
                805                 810                 815     


Thr Ile Leu Phe Gln Asn Val Ser Glu Lys Tyr Val Arg Val Lys Asn 
            820                 825                 830         


Lys Asn Gly Glu Leu Tyr Leu Phe Gln Ile Lys Asn Lys Asp Trp Asn 
        835                 840                 845             


Glu Gly Ser Thr Gly Lys Lys Asn Leu His Thr Leu Tyr Phe Glu Ser 
    850                 855                 860                 


Leu Phe Ser Lys Glu Asn Ala Lys Gln Gly Phe Pro Phe Lys Leu Ser 
865                 870                 875                 880 


Gly Asn Ala Glu Leu Phe Phe Arg Pro Gly Ser Ile Glu Gln Thr Tyr 
                885                 890                 895     


Glu Arg Arg Asn Phe Pro Arg Glu Ile Pro Leu Lys Arg Arg Tyr Ser 
            900                 905                 910         


Lys Asp Gly Ile Phe Phe His Ile Pro Val Gln Val Asn Arg Thr Lys 
        915                 920                 925             


Val Gly Ser Pro Asn Gln Phe Asn Lys Glu Val Asn Asp Phe Leu Ala 
    930                 935                 940                 


Gly Asn Pro Asn Ile Asn Ile Ile Gly Val Asp Arg Gly Glu Lys His 
945                 950                 955                 960 


Leu Val Tyr Tyr Ser Val Ile Ser Gln Asn Gly Glu Lys Ile Asp Gly 
                965                 970                 975     


Gly Ser Phe Asn Glu Ile Asn Gly Gln Asp Tyr His Asp Lys Leu Glu 
            980                 985                 990         


Lys Arg Ala Lys Glu Arg Glu Gln  Gln Arg Arg Asp Trp  Glu Thr Val 
        995                 1000                 1005             


Glu Gly  Ile Lys Asp Leu Lys  Lys Gly Tyr Ile Ser  Gln Val Val 
    1010                 1015                 1020             


Lys Lys  Leu Ala Asp Leu Ala  Ile Glu His Asn Ala  Ile Ile Val 
    1025                 1030                 1035             


Met Glu  Asp Leu Asn Met Arg  Phe Lys Gln Ile Arg  Gly Gly Ile 
    1040                 1045                 1050             


Glu Lys  Ser Val Tyr Gln Gln  Leu Glu Lys Ala Leu  Ile Asp Lys 
    1055                 1060                 1065             


Leu Ser  Phe Leu Val Asn Lys  Gly Glu Val Asp Pro  Gln Lys Ala 
    1070                 1075                 1080             


Gly His  Leu Leu Lys Ala Tyr  Gln Leu Thr Ala Pro  Ile Asp Ala 
    1085                 1090                 1095             


Phe Lys  Asp Met Gly Lys Gln  Thr Gly Ile Met Phe  Tyr Thr Gln 
    1100                 1105                 1110             


Ala Ala  Tyr Thr Ser Lys Ile  Asp Pro Val Thr Gly  Trp Arg Pro 
    1115                 1120                 1125             


His Leu  Tyr Leu Lys Tyr Ser  Ser Val Glu Lys Ala  Lys Asp Asp 
    1130                 1135                 1140             


Ile Ser  Arg Phe Thr Lys Ile  Ala Tyr Lys Asn Asp  Arg Phe Glu 
    1145                 1150                 1155             


Phe Thr  Tyr Asn Ile Thr Asp  Phe Arg Thr Gln Lys  Glu Trp Pro 
    1160                 1165                 1170             


Leu Lys  Thr Glu Trp Thr Val  Cys Ser Cys Val Glu  Arg Phe Arg 
    1175                 1180                 1185             


Trp Asn  Lys Lys Leu Ala Asn  Gly Lys Gly Asp Tyr  Glu His Tyr 
    1190                 1195                 1200             


Pro Asn  Val Thr Asp Asp Phe  Lys Lys Leu Phe Asp  Ser Val Gly 
    1205                 1210                 1215             


Ile Asn  Tyr Leu Gln Glu Asn  Ile Lys Ser Gln Val  Val Asn Leu 
    1220                 1225                 1230             


Asp Glu  Asn Thr Asn Val Glu  Phe Phe Arg Glu Phe  Ile Lys Leu 
    1235                 1240                 1245             


Phe Ala  Leu Val Cys Gln Ile  Arg Asn Thr Asn Ser  Glu Glu Ala 
    1250                 1255                 1260             


Gly Asn  Leu Asn Asp Phe Ile  Leu Ser Pro Val Glu  Pro Phe Phe 
    1265                 1270                 1275             


Asp Ser  Arg Ser Ala Glu Asp  Phe Gly Lys Gly Leu  Pro Ser Asn 
    1280                 1285                 1290             


Gly Asp  Glu Asn Gly Ala Tyr  Asn Ile Ala Arg Lys  Gly Met Ile 
    1295                 1300                 1305             


Ile Leu  Asn Thr Leu Ser Thr  Phe Lys Asn Asp His  Gly Ser Cys 
    1310                 1315                 1320             


Glu Gly  Leu Ser Trp Gly Asp  Leu Tyr Ile Ser Asp  Thr Gln Trp 
    1325                 1330                 1335             


Asp Asp  Phe Ala Gln Ser Phe  His Gly 
    1340                 1345         


<210> 18
<211> 1227
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 18
Met Asp Ala Lys Glu Phe Thr Gly Gln Tyr Pro Leu Ser Lys Thr Leu 
1               5                   10                  15      


Arg Phe Glu Leu Arg Pro Ile Gly Arg Thr Trp Asp Asn Leu Glu Ala 
            20                  25                  30          


Ser Gly Tyr Leu Ala Glu Asp Arg His Arg Ala Glu Cys Tyr Pro Arg 
        35                  40                  45              


Ala Lys Glu Leu Leu Asp Asp Asn His Arg Ala Phe Leu Asn Arg Val 
    50                  55                  60                  


Leu Pro Gln Ile Asp Met Asp Trp His Pro Ile Ala Glu Ala Phe Cys 
65                  70                  75                  80  


Lys Val His Lys Asn Pro Gly Asn Lys Glu Leu Ala Gln Asp Tyr Asn 
                85                  90                  95      


Leu Gln Leu Ser Lys Arg Arg Lys Glu Ile Ser Ala Tyr Leu Gln Asp 
            100                 105                 110         


Ala Asp Gly Tyr Lys Gly Leu Phe Ala Lys Pro Ala Leu Asp Glu Ala 
        115                 120                 125             


Met Lys Ile Ala Lys Glu Asn Gly Asn Glu Ser Asp Ile Glu Val Leu 
    130                 135                 140                 


Glu Ala Phe Asn Gly Phe Ser Val Tyr Phe Thr Gly Tyr His Glu Ser 
145                 150                 155                 160 


Arg Glu Asn Ile Tyr Ser Asp Glu Asp Met Val Ser Val Ala Tyr Arg 
                165                 170                 175     


Ile Thr Glu Asp Asn Phe Pro Arg Phe Val Ser Asn Ala Leu Ile Phe 
            180                 185                 190         


Asp Lys Leu Asn Glu Ser His Pro Asp Ile Ile Ser Glu Val Ser Gly 
        195                 200                 205             


Asn Leu Gly Val Asp Asp Ile Gly Lys Tyr Phe Asp Val Ser Asn Tyr 
    210                 215                 220                 


Asn Asn Phe Leu Ser Gln Ala Gly Ile Asp Asp Tyr Asn His Ile Ile 
225                 230                 235                 240 


Gly Gly His Thr Thr Glu Asp Gly Leu Ile Gln Ala Phe Asn Val Val 
                245                 250                 255     


Leu Asn Leu Arg His Gln Lys Asp Pro Gly Phe Glu Lys Ile Gln Phe 
            260                 265                 270         


Lys Gln Leu Tyr Lys Gln Ile Leu Ser Val Arg Thr Ser Lys Ser Tyr 
        275                 280                 285             


Ile Pro Lys Gln Phe Asp Asn Ser Lys Glu Met Val Asp Cys Ile Cys 
    290                 295                 300                 


Asp Tyr Val Ser Lys Ile Glu Lys Ser Glu Thr Val Glu Arg Ala Leu 
305                 310                 315                 320 


Lys Leu Val Arg Asn Ile Ser Ser Phe Asp Leu Arg Gly Ile Phe Val 
                325                 330                 335     


Asn Lys Lys Asn Leu Arg Ile Leu Ser Asn Lys Leu Ile Gly Asp Trp 
            340                 345                 350         


Asp Ala Ile Glu Thr Ala Leu Met His Ser Ser Ser Ser Glu Asn Asp 
        355                 360                 365             


Lys Lys Ser Val Tyr Asp Ser Ala Glu Ala Phe Thr Leu Asp Asp Ile 
    370                 375                 380                 


Phe Ser Ser Val Lys Lys Phe Ser Asp Ala Ser Ala Glu Asp Ile Gly 
385                 390                 395                 400 


Asn Arg Ala Glu Asp Ile Cys Arg Val Ile Ser Glu Thr Ala Pro Phe 
                405                 410                 415     


Ile Asn Asp Leu Arg Ala Val Asp Leu Asp Ser Leu Asn Asp Asp Gly 
            420                 425                 430         


Tyr Glu Ala Ala Val Ser Lys Ile Arg Glu Ser Leu Glu Pro Tyr Met 
        435                 440                 445             


Asp Leu Phe His Glu Leu Glu Ile Phe Ser Val Gly Asp Glu Phe Pro 
    450                 455                 460                 


Lys Cys Ala Ala Phe Tyr Ser Glu Leu Glu Glu Val Ser Glu Gln Leu 
465                 470                 475                 480 


Ile Glu Ile Ile Pro Leu Phe Asn Lys Ala Arg Ser Phe Cys Thr Arg 
                485                 490                 495     


Lys Arg Tyr Ser Thr Asp Lys Ile Lys Val Asn Leu Lys Phe Pro Thr 
            500                 505                 510         


Leu Ala Asp Gly Trp Asp Leu Asn Lys Glu Arg Asp Asn Lys Ala Ala 
        515                 520                 525             


Ile Leu Arg Lys Asp Gly Lys Tyr Tyr Leu Ala Ile Leu Asp Met Lys 
    530                 535                 540                 


Lys Asp Leu Ser Ser Ile Arg Thr Ser Asp Glu Asp Glu Ser Ser Phe 
545                 550                 555                 560 


Glu Lys Met Glu Tyr Lys Leu Leu Pro Ser Pro Val Lys Met Leu Pro 
                565                 570                 575     


Lys Ile Phe Val Lys Ser Lys Ala Ala Lys Glu Lys Tyr Gly Leu Thr 
            580                 585                 590         


Asp Arg Met Leu Glu Cys Tyr Asp Lys Gly Met His Lys Ser Gly Ser 
        595                 600                 605             


Ala Phe Asp Leu Gly Phe Cys His Glu Leu Ile Asp Tyr Tyr Lys Arg 
    610                 615                 620                 


Cys Ile Ala Glu Tyr Pro Gly Trp Asp Val Phe Asp Phe Lys Phe Arg 
625                 630                 635                 640 


Glu Thr Ser Asp Tyr Gly Ser Met Lys Glu Phe Asn Glu Asp Val Ala 
                645                 650                 655     


Gly Ala Gly Tyr Tyr Met Ser Leu Arg Lys Ile Pro Cys Ser Glu Val 
            660                 665                 670         


Tyr Arg Leu Leu Asp Glu Lys Ser Ile Tyr Leu Phe Gln Ile Tyr Asn 
        675                 680                 685             


Lys Asp Tyr Ser Glu Asn Ala His Gly Asn Lys Asn Met His Thr Met 
    690                 695                 700                 


Tyr Trp Glu Gly Leu Phe Ser Pro Gln Asn Leu Glu Ser Pro Val Phe 
705                 710                 715                 720 


Lys Leu Ser Gly Gly Ala Glu Leu Phe Phe Arg Lys Ser Ser Ile Pro 
                725                 730                 735     


Asn Asp Ala Lys Thr Val His Pro Lys Gly Ser Val Leu Val Pro Arg 
            740                 745                 750         


Asn Asp Val Asn Gly Arg Arg Ile Pro Asp Ser Ile Tyr Arg Glu Leu 
        755                 760                 765             


Thr Arg Tyr Phe Asn Arg Gly Asp Cys Arg Ile Ser Asp Glu Ala Lys 
    770                 775                 780                 


Ser Tyr Leu Asp Lys Val Lys Thr Lys Lys Ala Asp His Asp Ile Val 
785                 790                 795                 800 


Lys Asp Arg Arg Phe Thr Val Asp Lys Met Met Phe His Val Pro Ile 
                805                 810                 815     


Ala Met Asn Phe Lys Ala Ile Ser Lys Pro Asn Leu Asn Lys Lys Val 
            820                 825                 830         


Ile Asp Gly Ile Ile Asp Asp Gln Asp Leu Lys Ile Ile Gly Ile Asp 
        835                 840                 845             


Arg Gly Glu Arg Asn Leu Ile Tyr Val Thr Met Val Asp Arg Lys Gly 
    850                 855                 860                 


Asn Ile Leu Tyr Gln Asp Ser Leu Asn Ile Leu Asn Gly Tyr Asp Tyr 
865                 870                 875                 880 


Arg Lys Ala Leu Asp Val Arg Glu Tyr Asp Asn Lys Glu Ala Arg Arg 
                885                 890                 895     


Asn Trp Thr Lys Val Glu Gly Ile Arg Lys Met Lys Glu Gly Tyr Leu 
            900                 905                 910         


Ser Leu Ala Val Ser Lys Leu Ala Asp Met Ile Ile Glu Asn Asn Ala 
        915                 920                 925             


Ile Ile Val Met Glu Asp Leu Asn His Gly Phe Lys Ala Gly Arg Ser 
    930                 935                 940                 


Lys Ile Glu Lys Gln Val Tyr Gln Lys Phe Glu Ser Met Leu Ile Asn 
945                 950                 955                 960 


Lys Leu Gly Tyr Met Val Leu Lys Asp Lys Ser Ile Asp Gln Ser Gly 
                965                 970                 975     


Gly Ala Leu His Gly Tyr Gln Leu Ala Asn His Val Thr Thr Leu Ala 
            980                 985                 990         


Ser Val Gly Lys Gln Cys Gly Val  Ile Phe Tyr Ile Pro  Ala Ala Phe 
        995                 1000                 1005             


Thr Ser  Lys Ile Asp Pro Thr  Thr Gly Phe Ala Asp  Leu Phe Ala 
    1010                 1015                 1020             


Leu Ser  Asn Val Lys Asn Val  Ala Ser Met Arg Glu  Phe Phe Ser 
    1025                 1030                 1035             


Lys Met  Lys Ser Val Ile Tyr  Asp Lys Ala Glu Gly  Lys Phe Ala 
    1040                 1045                 1050             


Phe Thr  Phe Asp Tyr Leu Asp  Tyr Asn Val Lys Ser  Glu Cys Gly 
    1055                 1060                 1065             


Arg Thr  Leu Trp Thr Val Tyr  Thr Val Gly Glu Arg  Phe Thr Tyr 
    1070                 1075                 1080             


Ser Arg  Val Asn Arg Glu Tyr  Val Arg Lys Val Pro  Thr Asp Ile 
    1085                 1090                 1095             


Ile Tyr  Asp Ala Leu Gln Lys  Ala Gly Ile Ser Val  Glu Gly Asp 
    1100                 1105                 1110             


Leu Arg  Asp Arg Ile Ala Glu  Ser Asp Gly Asp Thr  Leu Lys Ser 
    1115                 1120                 1125             


Ile Phe  Tyr Ala Phe Lys Tyr  Ala Leu Asp Met Arg  Val Glu Asn 
    1130                 1135                 1140             


Arg Glu  Glu Asp Tyr Ile Gln  Ser Pro Val Lys Asn  Ala Ser Gly 
    1145                 1150                 1155             


Glu Phe  Phe Cys Ser Lys Asn  Ala Gly Lys Ser Leu  Pro Gln Asp 
    1160                 1165                 1170             


Ser Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala Leu Lys  Gly Ile Leu 
    1175                 1180                 1185             


Gln Leu  Arg Met Leu Ser Glu  Gln Tyr Asp Pro Asn  Ala Glu Ser 
    1190                 1195                 1200             


Ile Arg  Leu Pro Leu Ile Thr  Asn Lys Ala Trp Leu  Thr Phe Met 
    1205                 1210                 1215             


Gln Ser  Gly Met Lys Thr Trp  Lys Asn 
    1220                 1225         


<210> 19
<211> 1331
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 19
Met Val Asn Lys Gln Asn Glu Arg Gly Asp Phe Asp Asp Leu Thr Asn 
1               5                   10                  15      


Leu Tyr Glu Ile Ser Lys Thr Leu Arg Phe Glu Leu Val Pro Val Gly 
            20                  25                  30          


Glu Thr Asp Arg Met Leu Lys Glu Glu Asn Val Phe Lys Val Asp Glu 
        35                  40                  45              


Asn Ile Lys Arg Lys Tyr Gln Gln Thr Lys Leu Phe Phe Asp Arg Ile 
    50                  55                  60                  


His Arg Glu Phe Ala Lys Glu Ala Leu Ser Val Glu Gly Ile Leu Ser 
65                  70                  75                  80  


Glu Leu Glu Glu Tyr Leu Ala Ile Phe Ile Glu Trp Arg Lys Asp Lys 
                85                  90                  95      


Lys Ile His Glu Lys Thr Leu Asn Gln Lys Glu Lys Glu Leu Arg Lys 
            100                 105                 110         


Gln Val Val Ser Ala Phe Asn Ala Met Ala Asn Lys Trp Ile Glu Arg 
        115                 120                 125             


Tyr Gly Asp Val Asn Leu Lys Lys Lys Asn Val Glu Phe Leu Phe Glu 
    130                 135                 140                 


Glu Gly Ile Phe Arg Val Leu Lys Glu Arg Tyr Gly Glu Glu Asp Gly 
145                 150                 155                 160 


Ser Thr Ile Thr Ala Ser Asp Thr Gly Glu Val Phe Ser Ile Phe Asp 
                165                 170                 175     


Ser Trp Lys Gly Phe Thr Gly Tyr Phe Ala Lys Phe Phe Glu Thr Arg 
            180                 185                 190         


Lys Asn Phe Tyr Lys Asp Asp Gly Thr Ala Thr Ala Ile Ala Thr Arg 
        195                 200                 205             


Ile Val Asp Glu Asn Leu Arg Arg Phe Cys Asp Asn Leu Ile Val Ala 
    210                 215                 220                 


Gln Arg Leu Thr Glu Asn Ile Asp Phe Ser Glu Val Glu Asn Asn Phe 
225                 230                 235                 240 


Gln Ile Lys Ile Lys Glu Val Leu Phe Met Glu Phe Tyr Asn Lys Cys 
                245                 250                 255     


Leu Leu Gln Asp Asp Ile Asp Phe Tyr Asn Lys Val Ile Gly Gly Glu 
            260                 265                 270         


Thr Leu Lys Thr Gly Glu Lys Leu Lys Gly Ile Asn Glu Leu Val Asn 
        275                 280                 285             


Leu His Arg His Lys Thr Gly Glu Lys Leu Pro Phe Leu Lys Thr Leu 
    290                 295                 300                 


Asp Lys Gln Ile Leu Gly Arg Lys Glu Gln Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Ser Glu Glu Glu Leu Leu Glu Lys Leu Lys Asp Phe Gln Asn Val Ala 
                325                 330                 335     


Thr Lys Lys Ile Lys Val Ile Lys Ser Leu Phe Gly Asp Phe Val Glu 
            340                 345                 350         


Asn Asn Glu Asn Tyr Asp Leu Glu Lys Ile Tyr Ile Ser Lys Lys Ala 
        355                 360                 365             


Phe Asn Thr Ile Ser Arg Lys Trp Thr Gly Glu Thr Glu Gln Phe Glu 
    370                 375                 380                 


Lys Leu Leu Phe Glu Ser Met Lys Ser Asp Lys Pro Ala Gly Leu Lys 
385                 390                 395                 400 


Tyr Asp Lys Lys Glu Asn Asn Tyr Lys Phe Pro Asp Phe Ile Ala Val 
                405                 410                 415     


Ser Tyr Ile Lys Asp Ala Leu Glu Asn Phe Ser Gly Glu Gln Lys Phe 
            420                 425                 430         


Trp Lys Asp Arg Tyr Tyr Ile Glu Leu Glu Leu Asp Asn Gln Val Val 
        435                 440                 445             


Trp Lys Gln Phe Leu Asp Ile Phe Tyr Trp Glu Phe Ser Ser Leu Phe 
    450                 455                 460                 


Lys Arg Ser Phe Val Asn Lys Glu Thr Gly Glu Ile Ser Glu Val Gly 
465                 470                 475                 480 


Cys Asp Ile Phe Glu Lys Lys Phe Ile Asn Leu Ile Asp Asp Phe Glu 
                485                 490                 495     


Tyr Asn Gln Lys Ser Lys Ile Leu Ile Lys Asp Phe Ala Asp Ser Val 
            500                 505                 510         


Leu Ser Val Tyr Gln Met Ala Asn Tyr Phe Ser Leu Glu Lys Lys Arg 
        515                 520                 525             


Lys Trp Ser Thr Glu Phe Glu Thr Asp Ser Lys Phe Tyr Asp Asp Ser 
    530                 535                 540                 


Glu Ile Gly Phe Arg Asn Cys Phe Tyr Glu Asp Val Phe Glu Gly Ile 
545                 550                 555                 560 


Val Gln Val Tyr Asn Lys Leu Arg Asn Tyr Leu Thr Lys Lys Pro Phe 
                565                 570                 575     


Ser Glu Glu Lys Trp Lys Leu Asn Phe Glu Asn Pro Thr Leu Ala Ala 
            580                 585                 590         


Gly Trp Asp Lys Asn Lys Glu Lys Asp Asn Ser Thr Val Ile Leu Arg 
        595                 600                 605             


Lys Asp Glu Lys Tyr Phe Leu Ala Ile Met Lys Lys Gly Asn Asn Val 
    610                 615                 620                 


Ile Phe Asp Asp Arg Asn Lys Ala Leu Phe Ser Gln Asn Leu Glu His 
625                 630                 635                 640 


Gly Lys Tyr Glu Lys Val Val Tyr Lys Phe Ala Lys Asp Val Thr Leu 
                645                 650                 655     


Gly Ile Pro Lys Ser Thr Thr Gln Thr Lys Ser Val Ile Ala His Phe 
            660                 665                 670         


Lys Asn Ser Asp Glu Asp Tyr Gln Ile Thr Asn Gly Ser Ala Val Gly 
        675                 680                 685             


Asp Phe Leu Glu Pro Leu Val Val Thr Lys Arg Ile Phe Glu Leu Asn 
    690                 695                 700                 


Asn Lys Ile Tyr Ser Lys Asn Asn Leu Gly Lys Val Leu Tyr Arg Ser 
705                 710                 715                 720 


Glu Val Ser Lys Asp Lys Gln Lys Glu Tyr Ile Lys Leu Phe Gln Lys 
                725                 730                 735     


Lys Tyr Leu Val Leu Gly Gly Asn Lys Asn Leu Tyr Arg Asp Ala Val 
            740                 745                 750         


Lys Glu Trp Ile Asp Phe Cys Lys Ser Phe Ile Lys Val Tyr Pro Ser 
        755                 760                 765             


Tyr Lys Tyr Phe Asp Phe Ser Leu Leu Lys Glu Ala Val Glu Tyr Asn 
    770                 775                 780                 


Ser Val Asp Glu Phe Tyr Lys Glu Leu Asn Ser Tyr Gly Tyr Ala Ile 
785                 790                 795                 800 


Ser Phe Gln Asp Ile Ser Cys Asp Tyr Ile Glu Glu Lys Asn Lys Asn 
                805                 810                 815     


Gly Glu Leu Tyr Leu Phe Gln Ile Lys Asn Lys Asp Trp Asn Lys Gly 
            820                 825                 830         


Ser Thr Gly Met Lys Asn Leu His Thr Leu Tyr Phe Glu Ser Leu Phe 
        835                 840                 845             


Ser Glu Glu Asn Ile Lys Asn Asn Phe Val Thr Lys Leu Asn Gly Gly 
    850                 855                 860                 


Ala Glu Ile Phe Tyr Arg Pro Lys Thr Ser Lys Glu Lys Leu Gly Arg 
865                 870                 875                 880 


Lys Lys Ile Val Arg Asn Gly Gln Glu Val Phe Val Val Asn His Lys 
                885                 890                 895     


Arg Tyr Ser Glu Asp Lys Ile Phe Phe His Cys Ser Ile Ala Leu Asn 
            900                 905                 910         


Arg Gly Lys Gly Lys Leu Leu Lys Phe Asn Ala Arg Ile Asn Asp Leu 
        915                 920                 925             


Leu Ala Asn Asn Pro Asp Ile Asn Val Ile Gly Val Asp Arg Gly Glu 
    930                 935                 940                 


Lys His Leu Ala Tyr Tyr Ser Ile Ile Asp Gln Lys Cys Lys Ile Leu 
945                 950                 955                 960 


Asp Ser Gly Thr Leu Asn Glu Val Gly Ala Lys Val Asp Tyr His Glu 
                965                 970                 975     


Lys Leu Ser Asn Arg Ala Lys Lys Arg Glu Asp Gly Arg Arg Asp Trp 
            980                 985                 990         


Gly Trp Gly Gln Ile Glu Asp Ile  Lys Asn Leu Lys Lys  Gly Tyr Val 
        995                 1000                 1005             


Ser Gln  Val Val His Lys Leu  Ala Glu Leu Ile Ile  Lys Tyr Asn 
    1010                 1015                 1020             


Ala Ile  Leu Val Phe Glu Asp  Leu Asn Met Arg Phe  Lys Gln Ile 
    1025                 1030                 1035             


Arg Gly  Gly Ile Glu Lys Ser  Ile Tyr Gln Gln Leu  Glu Lys Ala 
    1040                 1045                 1050             


Leu Ile  Asp Lys Leu Asn Phe  Leu Val Lys Lys Gly  Glu Lys Asp 
    1055                 1060                 1065             


Ser Lys  Ser Ala Gly His Leu  Leu Lys Ala Tyr Gln  Leu Ala Ala 
    1070                 1075                 1080             


Pro Phe  Glu Thr Phe Asp Lys  Met Gly Lys Gln Thr  Gly Val Ile 
    1085                 1090                 1095             


Phe Tyr  Thr Gln Ala Ser Tyr  Thr Ser Lys Ile Asp  Pro Ile Thr 
    1100                 1105                 1110             


Gly Trp  Arg Pro Asn Leu Tyr  Leu Lys His Ser Asn  Ala Asn Asp 
    1115                 1120                 1125             


Ser Gln  Lys Lys Ile Ala Lys  Phe Ser Arg Ile Glu  Phe Ile Asn 
    1130                 1135                 1140             


Asp Arg  Phe Glu Phe Glu Tyr  Asp Leu Lys Lys Phe  Ile Glu Met 
    1145                 1150                 1155             


Lys Glu  Val Pro Glu Asn Thr  Lys Trp Thr Leu Cys  Ser Cys Val 
    1160                 1165                 1170             


Gln Arg  Tyr Arg Trp Asn Arg  Lys Leu Asn Ala Asn  Lys Gly Gly 
    1175                 1180                 1185             


Tyr Asp  Ser Tyr Asn Asp Leu  Thr Lys Asn Phe Lys  Ala Leu Phe 
    1190                 1195                 1200             


Glu Ser  Val Gly Ile Asp Ile  Lys Lys Asn Ile Lys  Glu Gln Ile 
    1205                 1210                 1215             


Val Lys  Met Glu Ile Lys Gly  Asn Glu Lys Phe Phe  Lys Ser Phe 
    1220                 1225                 1230             


Ile Phe  Tyr Trp Gln Leu Leu  Cys Gln Ile Arg Asn  Thr Asp Glu 
    1235                 1240                 1245             


Leu Lys  Lys Gly Asp Asp Asn  Asp Phe Ile Leu Ser  Pro Val Glu 
    1250                 1255                 1260             


Pro Phe  Phe Asp Ser Arg Lys  Lys Asn Gly Asp Asp  Leu Pro Lys 
    1265                 1270                 1275             


Asn Gly  Asp Asp Asn Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Val 
    1280                 1285                 1290             


Ile Val  Leu Asn Lys Ile Ser  Glu Phe Ser Lys Gln  Asn Gly Asn 
    1295                 1300                 1305             


Cys Glu  Lys Cys Gly Trp Lys  Glu Leu Tyr Val Ser  Ala Lys Asp 
    1310                 1315                 1320             


Trp Asp  Asp Phe Val Gln Ala  Lys 
    1325                 1330     


<210> 20
<211> 1275
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 20
Met Gln Asn Lys Gln Ser Phe Ala Asp Phe Thr Asn Leu Tyr Ser Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Ile Gly Gln Thr Gln Ala 
            20                  25                  30          


Met Leu Asp Glu Asn Lys Ile Phe Glu Val Asp Glu Asn Arg Lys Lys 
        35                  40                  45              


Ala Tyr Asp Lys Thr Lys Pro Tyr Phe Asp Arg Leu His Arg Glu Phe 
    50                  55                  60                  


Ile Asn Glu Ser Leu Ser Asn Ala Gln Leu Lys Gly Ile Ser Glu Tyr 
65                  70                  75                  80  


Phe Glu Thr Phe Lys Gln Phe Arg Ser Asn Gln Asn Asn Lys Asp Leu 
                85                  90                  95      


Lys Glu Leu Ile Asn Lys Gln Gln Lys Phe Leu Arg His Gln Ile Val 
            100                 105                 110         


Thr Leu Phe Asp Glu Asn Gly Lys His Trp Ala Thr Thr Lys Tyr Ala 
        115                 120                 125             


His Leu Lys Ile Lys Lys Lys Asn Leu Asp Ile Leu Phe Asp Glu Gln 
    130                 135                 140                 


Val Phe Tyr Ile Leu Lys Glu Arg Tyr Gly Ser Glu Lys Glu Thr Gln 
145                 150                 155                 160 


Leu Val Asp Lys Glu Thr Gly Ala Val Thr Ser Ile Phe Asp Asn Trp 
                165                 170                 175     


Lys Gly Phe Thr Gly Tyr Phe Thr Lys Phe Phe Glu Thr Arg Lys Asn 
            180                 185                 190         


Phe Tyr Lys Ser Asp Gly Thr Ser Thr Ala Leu Ala Thr Arg Ile Ile 
        195                 200                 205             


Asp Gln Asn Leu Asn Arg Phe Phe Asp Asn Leu Glu Thr Phe His Lys 
    210                 215                 220                 


Ile Lys Asp Lys Ile Asp Val Lys Glu Val Glu Ile Phe Phe Lys Leu 
225                 230                 235                 240 


Lys Ala Asp Asn Val Phe Ser Ile Asp Phe Tyr Asn Gln Cys Leu Leu 
                245                 250                 255     


Gln Asn Gly Ile Asp Lys Tyr Asn Asp Phe Leu Gly Gly Gln Thr Leu 
            260                 265                 270         


Glu Asn Gly Glu Lys Gln Lys Gly Ile Asn Glu Ile Ile Asn Lys Tyr 
        275                 280                 285             


Arg Gln Asp Asn Lys Asp Gln Lys Leu Pro Phe Leu Lys Lys Leu Asp 
    290                 295                 300                 


Lys Gln Ile Leu Ser Glu Lys Asp Arg Phe Ile Asn Glu Ile Glu Ser 
305                 310                 315                 320 


Lys Glu Glu Phe Phe Gln Val Leu Thr Glu Phe Tyr Gln Ser Ala Thr 
                325                 330                 335     


Val Lys Val Thr Ile Ile Lys Thr Leu Leu Asn Asp Phe Val His Asn 
            340                 345                 350         


Thr Asp Lys Tyr Lys Leu Glu Lys Ile Tyr Leu Thr Lys Glu Ala Phe 
        355                 360                 365             


Asn Thr Ile Ala Asn Lys Trp Thr Asp Glu Thr Gln Ile Phe Glu Asp 
    370                 375                 380                 


Asn Leu Asp Leu Val Leu Lys Asn Lys Lys Ile Thr Ala Lys Gln Asp 
385                 390                 395                 400 


Phe Ile Pro Leu Ala Tyr Ile Lys Glu Ala Leu Glu Val Ile Glu Lys 
                405                 410                 415     


Asp Arg Lys Phe Phe Lys Asp Arg Tyr Tyr Asn Asp Pro Gln Ile Gly 
            420                 425                 430         


Phe Phe Pro Asp Gln Ser Tyr Trp Glu Gln Phe Leu Ala Ile Leu Asn 
        435                 440                 445             


Phe Glu Phe Met Thr His Phe Gln Arg Val Ala Lys Asp Lys Ile Thr 
    450                 455                 460                 


Gly Lys Lys Ile Glu Leu Gly Tyr Phe Val Phe Glu Lys Arg Ile Lys 
465                 470                 475                 480 


Glu Leu Leu Asp Ser Asp Pro Ser Leu Asn Ser Gln Ser Lys Ile Ile 
                485                 490                 495     


Ile Lys Glu Phe Ala Asp Glu Val Leu His Ile Phe Gln Met Ala Lys 
            500                 505                 510         


Tyr Phe Ala Leu Glu Lys Lys Arg Glu Trp Lys Gly Asp Tyr Tyr Gln 
        515                 520                 525             


Leu Asp Asp Gln Phe Tyr Asn His Ile Asp Tyr Gly Phe Lys Asp Gln 
    530                 535                 540                 


Phe Tyr Glu Asn Ala Tyr Glu Lys Ile Val Gln Pro Tyr Asn Lys Ile 
545                 550                 555                 560 


Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser Asp Val Lys Trp Lys Leu 
                565                 570                 575     


Asn Phe Gly Asn Pro Thr Leu Ala Asn Gly Trp Asp Lys Asn Lys Glu 
            580                 585                 590         


Ala Asp Asn Thr Ala Val Ile Leu Lys Lys Asp Gly Asn Tyr Tyr Leu 
        595                 600                 605             


Gly Val Met Lys Lys Gly Lys Asn Lys Ile Phe Ser Asp Gln Asn Lys 
    610                 615                 620                 


Glu Lys Tyr Lys Ala Tyr Asn Ser Ala Tyr Tyr Glu Lys Leu Val Tyr 
625                 630                 635                 640 


Lys Leu Phe Pro Asp Pro Ser Lys Met Phe Pro Lys Val Cys Phe Ser 
                645                 650                 655     


Lys Lys Gly Leu Asn Phe Phe Gln Pro Ser Glu Glu Ile Leu Arg Ile 
            660                 665                 670         


Tyr Lys Asn Asn Glu Phe Lys Lys Gly Asn Thr Phe Ser Ile Ser Ser 
        675                 680                 685             


Met Gln Lys Leu Ile Ala Phe Tyr Ile Asp Cys Leu Gly Leu Tyr Glu 
    690                 695                 700                 


Gly Trp Lys His Tyr Glu Phe Lys Asn Ile Lys Asp Val Arg Gln Tyr 
705                 710                 715                 720 


Lys Glu Asn Ile Gly Glu Phe Tyr Ala Asp Val Ala Glu Ser Gly Tyr 
                725                 730                 735     


Lys Leu Trp Phe Glu Lys Ile Ser Glu Glu Tyr Ile Thr Gln Lys Asn 
            740                 745                 750         


Gln Leu Gly Glu Leu Phe Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala 
        755                 760                 765             


Lys Lys Thr Thr Gly Arg Lys Asn Leu His Thr Ile Tyr Phe Glu Glu 
    770                 775                 780                 


Leu Phe Ser Gln Thr Asn Ile Asp Asn Asn Phe Pro Phe Lys Leu Asn 
785                 790                 795                 800 


Gly Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Leu Glu Lys Ile Glu 
                805                 810                 815     


Glu Lys Arg Asn Phe Lys Arg Ser Ile Val Asn Lys Lys Arg Tyr Thr 
            820                 825                 830         


Gln Asn Lys Ile Phe Phe His Val Pro Ile Thr Leu Asn Arg Thr Ser 
        835                 840                 845             


Glu Asn Ile Gly Arg Phe Asn Val Arg Val Asn Asn Phe Leu Ala Asn 
    850                 855                 860                 


Asn Ser Asn Val Asn Ile Val Gly Val Asp Arg Gly Glu Lys Asn Leu 
865                 870                 875                 880 


Ala Tyr Tyr Ser Ile Ile Lys Gln Asn Gly Glu Val Leu Lys Ser Gly 
                885                 890                 895     


Ser Leu Asn Ile Ile Asn Gly Val Asp Tyr His Ala Leu Leu Thr Asp 
            900                 905                 910         


Arg Ala Gln Arg Arg Glu Gln Glu Arg Arg Asn Trp Gln Asp Val Glu 
        915                 920                 925             


Ser Ile Lys Asp Leu Lys Arg Gly Tyr Ile Ser Gln Val Val His Glu 
    930                 935                 940                 


Leu Val Ser Leu Ala Ile Lys Tyr Asn Ala Ile Ile Val Met Glu Asp 
945                 950                 955                 960 


Leu Asn Met Arg Phe Lys Gln Ile Arg Gly Gly Ile Glu Lys Ser Thr 
                965                 970                 975     


Tyr Gln Gln Leu Glu Lys Ala Leu Ile Glu Lys Leu Asn Phe Leu Val 
            980                 985                 990         


Asn Lys Glu Glu Thr Asp Ser Asn  Gln Ala Gly Asn Leu  Leu Asn Ala 
        995                 1000                 1005             


Tyr Gln  Leu Thr Ala Pro Phe  Lys Thr Phe Lys Asp  Met Gly Lys 
    1010                 1015                 1020             


Gln Thr  Gly Ile Ile Phe Tyr  Thr Gln Ala Ser Tyr  Thr Ser Lys 
    1025                 1030                 1035             


Ile Asp  Pro Leu Thr Gly Trp  Arg Pro Asn Ile Tyr  Leu Arg Tyr 
    1040                 1045                 1050             


Ser Asn  Ala Lys Gln Ala Lys  Ala Asp Ile Leu Met  Phe Thr Asn 
    1055                 1060                 1065             


Ile Tyr  Phe Ser Glu Lys Lys  Asp Arg Phe Glu Phe  Thr Tyr Asp 
    1070                 1075                 1080             


Leu Glu  Lys Ile Asp Asp Lys  Arg Lys Asp Leu Pro  Ile Lys Thr 
    1085                 1090                 1095             


Glu Trp  Thr Val Cys Ser Asn  Val Glu Arg Phe Ser  Trp Glu Lys 
    1100                 1105                 1110             


Ser Leu  Asn Asn Asn Lys Gly  Gly Tyr Val His Tyr  Pro Ile Gln 
    1115                 1120                 1125             


Asp Ser  Asn Gly Glu Glu Ser  Ile Thr Ser Lys Leu  Lys Lys Leu 
    1130                 1135                 1140             


Phe Met  Asp Phe Gly Ile Asp  Leu Thr Asp Ile Lys  Thr Gln Ile 
    1145                 1150                 1155             


Glu Ser  Leu Asp Thr Asn Lys  Lys Asp Asn Ala Asn  Phe Phe Arg 
    1160                 1165                 1170             


Lys Phe  Ile Phe Tyr Phe Gln  Leu Ile Cys Gln Ile  Arg Asn Thr 
    1175                 1180                 1185             


Gln Val  Asn Lys Ser Asp Asp  Gly Asn Asp Phe Ile  Phe Ser Pro 
    1190                 1195                 1200             


Val Glu  Pro Phe Phe Asp Ser  Arg Phe Ala Asp Lys  Phe Arg Lys 
    1205                 1210                 1215             


Asn Leu  Pro Lys Asn Gly Asp  Glu Asn Gly Ala Tyr  Asn Ile Ala 
    1220                 1225                 1230             


Arg Lys  Gly Leu Ile Ile Leu  His Lys Ile Ser Asp  Tyr Phe Val 
    1235                 1240                 1245             


Lys Glu  Gly Ser Thr Asp Lys  Ile Ser Trp Lys Asp  Leu Ser Ile 
    1250                 1255                 1260             


Ser Gln  Thr Glu Trp Asp Asn  Phe Thr Thr Asp Lys  
    1265                 1270                 1275 


<210> 21
<211> 1313
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 21
Met Asp Lys Gln Lys Asn Lys Leu Gln Asn Phe Thr Asn Leu Tyr Glu 
1               5                   10                  15      


Leu Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Glu Thr Gln 
            20                  25                  30          


His Leu Leu Glu Glu Asn Lys Val Phe Gly Ile Asp Gly Asn Ile Lys 
        35                  40                  45              


Lys Lys Tyr Glu Ala Thr Lys Pro Phe Phe Asp Arg Leu His Arg Lys 
    50                  55                  60                  


Phe Val Lys Glu Ala Leu Val Asn Ile Ala Leu Gly Gly Leu Asp Asn 
65                  70                  75                  80  


Tyr Leu Glu Val Tyr Lys Lys Phe Thr Asn Asp Arg Lys Asp Lys Glu 
                85                  90                  95      


Asn Gln Lys Glu Leu Glu Lys Gln Glu Lys Leu Leu Arg Lys Gln Ile 
            100                 105                 110         


Lys Ile Phe Phe Asp Ser Gln Ala Asn Gln Trp Lys Glu Lys Tyr Asn 
        115                 120                 125             


Lys Ile Asn Phe Lys Lys Ser Gly Leu Asn Ile Leu Phe Glu Glu Ser 
    130                 135                 140                 


Ile Phe Gln Leu Leu Lys Glu Ile Tyr Gly Lys Glu Asp Asp Ala Phe 
145                 150                 155                 160 


Leu Lys Asn Asp Asp Asn Glu Phe Ile Phe Asp Lys Asp Gly Asn Lys 
                165                 170                 175     


Ile Ser Ile Phe Asp Ser Trp Lys Gly Phe Thr Gly Tyr Phe Lys Lys 
            180                 185                 190         


Phe Phe Glu Thr Arg Lys Asn Phe Tyr Lys Asp Asp Gly Thr Ser Thr 
        195                 200                 205             


Ala Ile Ala Thr Arg Ile Ile Asp Gln Asn Leu Arg Arg Phe Cys Asp 
    210                 215                 220                 


Asn Ile Phe Ile Tyr Asn Lys Ile Lys Asn Lys Leu Asp Phe Ser Ser 
225                 230                 235                 240 


Leu Glu Lys Glu Gln Asp Val Val Leu Glu Glu Ile Phe Thr Thr Ala 
                245                 250                 255     


Tyr Tyr Met Asp Cys Ile Leu Gln Asp Asp Ile Asp Leu Tyr Asn Gly 
            260                 265                 270         


Val Leu Gly Gly Glu Thr Leu Asp Asp Gly Thr Lys Ile Lys Gly Leu 
        275                 280                 285             


Asn Glu Ile Ile Asn Lys Tyr Arg Gln Asp Asn Lys Gly Asp Lys Ile 
    290                 295                 300                 


Pro Phe Phe Lys Lys Leu Asp Lys Gln Ile Leu Ser Glu Lys Asp Arg 
305                 310                 315                 320 


Lys Phe Leu Asp Glu Ile Glu Ser Glu Glu Glu Leu Ala Glu Leu Leu 
                325                 330                 335     


Lys Ile Phe Ile Asn Asn Thr Glu Ala Lys Val Lys Val Phe Asp Glu 
            340                 345                 350         


Leu Val Asn Gln Leu Cys Val Asn Asp Ser Asp Phe Glu Leu Asp Lys 
        355                 360                 365             


Ile Tyr Ile Ser Lys Glu Ala Phe Asn Thr Ile Ser His Lys Trp Thr 
    370                 375                 380                 


Asn Gln Thr His Glu Phe Glu Arg Val Leu Phe Glu Glu Met Lys Pro 
385                 390                 395                 400 


Asp Lys Ile Thr Gly Leu Asp Tyr Lys Lys Ala Glu Asp Lys Tyr Lys 
                405                 410                 415     


Phe Pro Asp Phe Ile Ala Leu Lys Tyr Ile Ile Lys Ser Leu Asn Thr 
            420                 425                 430         


Leu Asp Lys Asp Ser Glu Phe Trp Lys Ser His Tyr Tyr Lys Thr Glu 
        435                 440                 445             


Glu Asn Gln Asn Ala Ile Leu Ser Leu Glu Glu Lys Val Gly Glu Gln 
    450                 455                 460                 


Phe Leu Gln Ile Tyr Lys Tyr Glu Leu Gln Arg Leu His Ser Arg Asn 
465                 470                 475                 480 


Val Asn Val Glu Asn Lys Asp Gly Lys Met Lys Glu Lys Glu Ile Gly 
                485                 490                 495     


Leu Asp Tyr Ser Leu Thr Thr Val Lys Glu Leu Leu Lys Asn Phe Lys 
            500                 505                 510         


Leu Thr Asp Lys Ser Lys Ile Ile Ile Lys Asp Phe Ala Asp Asn Val 
        515                 520                 525             


Leu Gln Tyr Tyr Gln Leu Ala Lys Tyr Phe Ser Val Glu Lys Asn Arg 
    530                 535                 540                 


Glu Trp Asn Tyr Thr Lys Leu Glu Leu Ala Asp Phe Tyr Ile Asn Pro 
545                 550                 555                 560 


Asp Phe Gly Tyr Glu Ile Phe Tyr Gly Asn Ala Tyr Glu Glu Ile Ile 
                565                 570                 575     


Gln Ile Tyr Asn Lys Leu Arg Asn Tyr Leu Thr Lys Lys Pro Phe Ser 
            580                 585                 590         


Glu Glu Lys Trp Lys Leu Asn Phe Glu Asn Pro Thr Leu Ala Gly Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Arg Gly Asn Ala Thr Val Ile Leu Arg Lys 
    610                 615                 620                 


Asn Glu Lys Tyr Tyr Leu Gly Ile Met Ala Lys Gly Tyr Asn Asp Ile 
625                 630                 635                 640 


Phe Thr Asp Lys Asn Lys Asp Lys Phe Asp Gly Glu Gly Tyr Glu Lys 
                645                 650                 655     


Met Val Tyr Lys Leu Phe Pro Gly Pro Asn Lys Met Met Pro Lys Val 
            660                 665                 670         


Cys Phe Ser Lys Lys Gly Leu Asp Phe Phe Glu Pro Ser Glu Lys Ile 
        675                 680                 685             


Ile Asp Ile Tyr Lys Asp Gly Lys Phe Lys Gln Gly Asp Thr Phe Ser 
    690                 695                 700                 


Ile Asp Ser Met Gln Gln Leu Ile Asp Phe Tyr Lys Arg Ala Leu Arg 
705                 710                 715                 720 


Glu Tyr Asn Gly Trp Lys Met Tyr Asp Phe Ser Lys Leu Lys Asp Thr 
                725                 730                 735     


Asn Asp Tyr Thr Thr Asn Ile Gly Glu Phe Tyr Asn Asp Val Ala Cys 
            740                 745                 750         


Ala Gly Tyr Lys Val Trp Phe Asp Asn Ile Ser Glu Glu Tyr Ile Gln 
        755                 760                 765             


Glu Lys Asn Glu Asn Gly Glu Leu Tyr Leu Phe Glu Ile His Asn Lys 
    770                 775                 780                 


Asp Trp Asn Leu Lys Asp Glu Lys Lys Lys Thr Gly Thr Lys Asn Leu 
785                 790                 795                 800 


His Thr Leu Tyr Phe Glu Ser Leu Phe Ser Asp Glu Asn Ala Leu Arg 
                805                 810                 815     


Asp Phe Val Met Lys Leu Ser Gly Glu Ala Glu Leu Phe Phe Arg Pro 
            820                 825                 830         


Lys Thr Asn Ala Asp Lys Leu Gly Tyr Arg Lys Asp Lys Lys Gly Asn 
        835                 840                 845             


Lys Val Val Lys Asn Lys Arg Tyr Ser Glu Asp Lys Met Phe Leu His 
    850                 855                 860                 


Leu Ser Ile Asn Leu Asn Arg Gly Lys Gly Gln Ala Phe Trp Phe Asn 
865                 870                 875                 880 


Arg Asn Ile Asn Asn Phe Leu Ala Asn Asn Ser Asp Ile Asn Val Ile 
                885                 890                 895     


Gly Ile Asp Arg Gly Glu Lys His Leu Ala Tyr Tyr Ser Val Ile Ser 
            900                 905                 910         


Gln Gln Gly Glu Ile Leu Asp Asn Gly Ser Leu Asn Glu Ile Ala Gly 
        915                 920                 925             


Val Asp Tyr Tyr Ala Lys Leu Ser Lys Arg Ala Lys Glu Arg Glu Gly 
    930                 935                 940                 


Gln Arg Lys Asp Trp Gln Ala Val Ser Asp Ile Lys Asn Leu Lys Lys 
945                 950                 955                 960 


Gly Tyr Ile Ser Gln Val Val Arg Lys Leu Ala Asp Leu Ala Ile Glu 
                965                 970                 975     


His Asn Ala Ile Ile Val Leu Glu Asp Leu Asn Met Arg Phe Lys Gln 
            980                 985                 990         


Ile Arg Gly Gly Ile Glu Lys Ser  Ile Tyr Gln Gln Leu  Glu Lys Ala 
        995                 1000                 1005             


Leu Ile  Glu Lys Leu Asn Phe  Leu Val Asn Lys Lys  Glu Ile Asp 
    1010                 1015                 1020             


Ser Asp  Lys Ala Gly Asn Leu  Leu Arg Ala Tyr Gln  Leu Thr Ala 
    1025                 1030                 1035             


Pro Phe  Glu Thr Phe Gln Lys  Met Gly Lys Gln Thr  Gly Ile Ile 
    1040                 1045                 1050             


Phe Tyr  Thr Gln Ala Ser Tyr  Thr Ser Lys Ile Asp  Pro Leu Thr 
    1055                 1060                 1065             


Gly Trp  Arg Pro Asn Leu Tyr  Leu Lys Lys Gly Asn  Ala Lys Ile 
    1070                 1075                 1080             


Asn Lys  Glu Gln Ile Glu Lys  Phe Ser Lys Ile Glu  Phe Thr Asn 
    1085                 1090                 1095             


Asn Arg  Phe Glu Ile Thr Tyr  Asp Leu Lys Asn Phe  Gly Asp Lys 
    1100                 1105                 1110             


Lys Lys  Lys Tyr Pro Gln Lys  Thr Lys Trp Thr Leu  Cys Ser Ser 
    1115                 1120                 1125             


Val Glu  Arg Trp Arg Trp Asp  Arg Lys Leu Asn Asn  Asn Lys Gly 
    1130                 1135                 1140             


Gly Tyr  Ile His Tyr Glu Asp  Leu Thr Thr Glu Phe  Lys Ser Leu 
    1145                 1150                 1155             


Phe Glu  Lys Phe Glu Ile Asp  Ile Glu Gly Asp Ile  Leu Glu Gln 
    1160                 1165                 1170             


Ile Lys  Thr Ile Asp Glu Asn  Asp Arg Asn Asn Ala  Arg Leu Phe 
    1175                 1180                 1185             


Ser Gly  Phe Ile Tyr Leu Trp  Gly Leu Leu Ser Gln  Ile Arg Asn 
    1190                 1195                 1200             


Thr Asp  Gly Glu Leu Asp Glu  Lys Ile Lys Lys Leu  Glu Arg Glu 
    1205                 1210                 1215             


Asp Lys  Asn Glu Glu Ile Ser  Glu Lys Glu Lys Phe  Asp Val Asp 
    1220                 1225                 1230             


Phe Ile  Leu Ser Pro Val Glu  Pro Phe Phe Asp Ser  Arg Thr Pro 
    1235                 1240                 1245             


Glu Lys  Phe Gly Glu Asn Leu  Pro Lys Asn Gly Asp  Asp Asn Gly 
    1250                 1255                 1260             


Ala Tyr  Asn Ile Ala Arg Lys  Gly Ile Ile Thr Leu  Glu Arg Ile 
    1265                 1270                 1275             


Lys Lys  Phe Tyr Glu Leu Ser  Asp Lys Glu Arg Glu  Lys Leu Lys 
    1280                 1285                 1290             


Tyr Pro  Asp Leu Phe Ile Thr  Asn Ala Glu Trp Asp  Asp Phe Ala 
    1295                 1300                 1305             


Thr Lys  Arg Asp Ser 
    1310             


<210> 22
<211> 1155
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 22
Met Asp Asn Asn Thr Thr Leu Glu Lys Thr Glu Leu Gly Leu Gly Ile 
1               5                   10                  15      


Thr Tyr Asn His Asp Lys Val Glu Asp Lys His Tyr Phe Gly Gly Phe 
            20                  25                  30          


Phe Asn Leu Ala Gln Asn Asn Ile Asp Leu Val Ala Gln Glu Phe Lys 
        35                  40                  45              


Lys Arg Leu Leu Val Gln Gly Lys Asp Ser Ile Asn Ile Phe Ser Asn 
    50                  55                  60                  


Tyr Phe Ser Asp Gln Cys Ser Ile Thr Asn Leu Glu Arg Gly Ile Lys 
65                  70                  75                  80  


Val Leu Ser Glu Tyr Phe Pro Val Ile Phe Tyr Phe Asp Leu Asp Glu 
                85                  90                  95      


Asn Asn Lys Ser Lys Ser Ile Arg Gln His Ile Ile Leu Leu Leu Asp 
            100                 105                 110         


Thr Ile Asn Asn Leu Arg Asn Tyr Tyr Thr His Tyr Tyr His Lys Lys 
        115                 120                 125             


Val Ile Ile Asp Asp Ala Leu Tyr Pro Leu Leu Asp Thr Ile Leu Leu 
    130                 135                 140                 


Lys Val Val Leu Glu Ile Lys Lys Lys Lys Leu Lys Glu Asp Lys Thr 
145                 150                 155                 160 


Lys Gln Leu Leu Lys Lys Gly Leu Glu Lys Glu Met Ala Ile Leu Phe 
                165                 170                 175     


Asn Leu Met Lys Lys Glu Gln Lys Glu Lys Lys Ile Lys Gly Trp Asn 
            180                 185                 190         


Ile Asp Lys Asn Ile Lys Gly Ala Val Leu Asn Arg Ala Phe Ser His 
        195                 200                 205             


Leu Leu Tyr Asn Asp Gly Ile Ser Asp Tyr Arg Lys Ser Lys Ser Asn 
    210                 215                 220                 


Thr Glu Asp Glu Asn Leu Lys Asp Thr Leu Ser Glu Ser Gly Ile Leu 
225                 230                 235                 240 


Phe Leu Leu Ser Phe Phe Leu Asn Lys Lys Glu Gln Glu Gln Leu Lys 
                245                 250                 255     


Ala Asn Ile Lys Gly Tyr Lys Gly Lys Ile Ala Ser Ile Pro Asp Glu 
            260                 265                 270         


Glu Ile Thr Leu Lys Asn Asn Ser Leu Arg Asn Met Ala Thr His Trp 
        275                 280                 285             


Thr Tyr Ser His Leu Thr Tyr Lys Gly Leu Lys His Arg Ile Lys Thr 
    290                 295                 300                 


Asp His Glu Lys Glu Thr Leu Leu Val Asn Met Val Asp Tyr Leu Ser 
305                 310                 315                 320 


Lys Val Pro Asn Glu Ile Tyr Gln Asn Leu Ser Glu Gln Asn Lys Ser 
                325                 330                 335     


Leu Phe Leu Glu Asp Ile Asn Glu Tyr Met Arg Asp Asn Glu Glu Asn 
            340                 345                 350         


Asn Asp Ser Ser Glu Ala Ser Arg Val Ile His Pro Val Ile Arg Lys 
        355                 360                 365             


Arg Tyr Glu Asn Lys Phe Ala Tyr Phe Ala Ile Arg Phe Leu Asp Glu 
    370                 375                 380                 


Phe Ala Glu Phe Pro Thr Leu Arg Phe Met Val Asn Val Gly Asn Tyr 
385                 390                 395                 400 


Ile His Asp Asn Arg Lys Lys Asp Ile Gly Gly Thr Ser Leu Ile Thr 
                405                 410                 415     


Asn Arg Thr Ile Lys Gln Gln Ile Asn Val Phe Gly Asn Leu Thr Glu 
            420                 425                 430         


Ile His Lys Lys Lys Asn Asp Tyr Phe Glu Lys Glu Glu Asn Lys Glu 
        435                 440                 445             


Lys Ile Leu Glu Trp Glu Leu Phe Pro Asn Pro Ser Tyr His Phe Gln 
    450                 455                 460                 


Lys Glu Asn Ile Pro Ile Phe Ile Asp Leu Glu Lys Ser Lys Glu Thr 
465                 470                 475                 480 


Asn Glu Leu Ala Lys Glu Tyr Ala Lys Glu Lys Lys Lys Ile Phe Gly 
                485                 490                 495     


Ser Ser Arg Lys Lys Gln Gln Asn Thr Ala Lys Lys Asn Arg Glu Ala 
            500                 505                 510         


Ile Ile Asn Leu Val Phe Asp Lys Tyr Lys Thr Ser Asp Arg Lys Thr 
        515                 520                 525             


Val Thr Phe Glu Gln Pro Thr Ala Leu Leu Ser Phe Asn Glu Leu Asn 
    530                 535                 540                 


Ala Phe Leu Tyr Ala Phe Leu Val Glu Asn Lys Thr Gly Lys Glu Leu 
545                 550                 555                 560 


Glu Lys Ile Ile Ile Glu Lys Ile Ala Asn Gln Tyr Gln Ile Leu Lys 
                565                 570                 575     


Asn Cys Ser Ser Thr Val Asp Lys Thr Asn Asp Ser Ile Pro Lys Ser 
            580                 585                 590         


Ile Lys Lys Ile Ala His Pro Thr Thr Asp Ser Phe Tyr Ser Glu Gly 
        595                 600                 605             


Lys Lys Ile Asp Ile Glu Lys Leu Glu Arg Asp Ile Lys Ile Glu Ile 
    610                 615                 620                 


Glu Lys Thr Asn Glu Lys Leu Glu Thr Ile Lys Glu Asn Glu Thr Ser 
625                 630                 635                 640 


Ala Lys Asn Tyr Lys Arg Asn Glu Arg Asp Ile Gln Lys Arg Lys Leu 
                645                 650                 655     


Tyr Arg Lys Tyr Val Phe Phe Thr Asn Glu Ile Gly Ile Glu Ala Thr 
            660                 665                 670         


Trp Ile Thr Asn Asp Ile Leu Arg Phe Leu Asp Asn Lys Glu Asn Trp 
        675                 680                 685             


Lys Gly Tyr Gln His Ser Glu Leu Gln Lys Phe Ile Ser Gln Tyr Asp 
    690                 695                 700                 


Asn Tyr Lys Lys Glu Ala Leu Gly Leu Leu Glu Ser Glu Trp Asn Leu 
705                 710                 715                 720 


Glu Ser Glu Ala Phe Phe Gly Gln Lys Leu Lys Arg Ile Phe Gln Ser 
                725                 730                 735     


Asn Phe Thr Phe Glu Thr Phe Tyr Lys Lys Tyr Leu Asp Asn Arg Lys 
            740                 745                 750         


Asp Thr Leu Glu Thr Tyr Leu Ser Ala Ile Glu Asn Leu Lys Thr Met 
        755                 760                 765             


Thr Asp Val Pro Pro Lys Ile Leu Lys Lys Ser Trp Ala Glu Leu Phe 
    770                 775                 780                 


Arg Phe Phe Asp Lys Lys Ile Tyr Leu Leu Ser Thr Ile Glu Thr Lys 
785                 790                 795                 800 


Ile Asn Glu Leu Ile Thr Lys Pro Ile Asn Leu Ser Arg Gly Val Phe 
                805                 810                 815     


Asp Glu Lys Pro Thr Phe Ile Asn Gly Lys Ser Pro Asn Lys Glu Asn 
            820                 825                 830         


Asp Gln His Leu Phe Ala Asn Trp Phe Ile His Ala Lys Glu Gln Thr 
        835                 840                 845             


Ile Phe Gln Asp Phe Tyr Asn Leu Ala Leu Glu Thr Pro Lys Glu Ile 
    850                 855                 860                 


Asn Asn Leu Lys Lys Gln Asn Tyr Lys Leu Glu Arg Ser Ile Asn Asn 
865                 870                 875                 880 


Leu Lys Ile Glu Asp Ile Tyr Ile Lys Gln Met Val Asp Phe Leu Tyr 
                885                 890                 895     


Gln Lys Leu Phe Glu Gln Ser Phe Lys Gly Ser Leu Gln Asp Leu Tyr 
            900                 905                 910         


Thr Ser Lys Glu Lys Arg Glu Val Glu Lys Ser Lys Ala Lys Asn Glu 
        915                 920                 925             


Gln Thr Pro Asp Glu Ser Phe Ile Trp Lys Lys Gln Val Glu Ile Asn 
    930                 935                 940                 


Ala Leu Asn Gly Arg Ile Ile Ala Lys Thr Lys Ile Lys Asp Ile Gly 
945                 950                 955                 960 


Lys Phe Lys Asn Leu Leu Thr Asp Asn Lys Ile Thr His Leu Ile Ser 
                965                 970                 975     


Tyr Asp Asn Arg Ile Trp Asn Phe Ser Leu Asp Asn Asp Gly Asp Thr 
            980                 985                 990         


Thr Lys Lys Leu Tyr Ser Leu Asn  Thr Glu Leu Glu Ser  Tyr Glu Arg 
        995                 1000                 1005             


Ile Arg  Arg Glu Lys Leu Leu  Lys Gln Ile Gln Glu  Phe Glu Gln 
    1010                 1015                 1020             


Phe Leu  Leu Lys Gln Glu Thr  Glu Tyr Ser Ala Glu  Arg Lys His 
    1025                 1030                 1035             


Pro Glu  Lys Phe Glu Lys Asp  Gly Asn Pro Asn Phe  Lys Lys Tyr 
    1040                 1045                 1050             


Ile Ile  Glu Gly Met Leu Asn  Lys Ile Thr Pro Val  Asn Glu Ile 
    1055                 1060                 1065             


Glu Glu  Leu Glu Ile Leu Lys  Ser Lys Glu Asp Val  Phe Lys Ile 
    1070                 1075                 1080             


Asp Phe  Asn Glu Ile Val Lys  Leu Asn Asn Glu Ser  Ile Lys Lys 
    1085                 1090                 1095             


Gly Tyr  Leu Leu Ile Met Ile  Arg Asn Lys Phe Ala  His Asn Gln 
    1100                 1105                 1110             


Leu Ile  Asp Lys Asn Leu Phe  Thr Phe Ser Leu Gln  Leu Tyr Ser 
    1115                 1120                 1125             


Lys Asn  Glu Asn Glu Asn Phe  Ser Glu Tyr Leu Asp  Lys Val Cys 
    1130                 1135                 1140             


Gln Lys  Ile Ile Gln Glu Phe  Ile Glu Lys Leu Lys  
    1145                 1150                 1155 


<210> 23
<211> 1134
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 23
Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210> 24
<211> 1145
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 24
Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Val Glu Asn Asn 
            20                  25                  30          


Leu Asn Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Tyr Lys Ala 
        35                  40                  45              


Lys Asp Glu Asn Ile Ser Ser Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Lys Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Asn Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Ile Glu Lys Leu Arg Asp Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Glu Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Ile Gln His Thr Asp Ser Ser Gln Ile Lys Asn Ser Ile Phe 
        195                 200                 205             


Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Gly Asn Asn Lys 
    210                 215                 220                 


Lys Thr Gln Val Ser His Arg Ala Lys Thr Arg Leu Asn Pro Lys Asp 
225                 230                 235                 240 


Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr Ser 
                245                 250                 255     


Gly Leu Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile Glu 
            260                 265                 270         


Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys Asp 
        275                 280                 285             


Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr Ser 
    290                 295                 300                 


Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr Phe 
305                 310                 315                 320 


Ser Lys Glu Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys Val 
                325                 330                 335     


Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp Phe 
            340                 345                 350         


Ile Glu Asp Trp Asn Glu Tyr Phe Lys Asp Asn Glu Glu Asn Thr Glu 
        355                 360                 365             


Asn Leu Glu Asn Ser Arg Val Val His Pro Val Ile Arg Lys Arg Tyr 
    370                 375                 380                 


Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala 
385                 390                 395                 400 


Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile His 
                405                 410                 415     


Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu Arg 
            420                 425                 430         


Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met Asp 
        435                 440                 445             


Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Asp Glu Asn Thr 
    450                 455                 460                 


Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln Ala 
465                 470                 475                 480 


Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys Asn 
                485                 490                 495     


Gln Gln Ile Ile Lys Glu Lys Asp Ala Ile Lys Ala Glu Val Asn Gln 
            500                 505                 510         


Thr Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu Asn 
        515                 520                 525             


Lys Ile Leu Lys Thr Tyr Glu Asp Phe His Gln Gly Asp Pro Thr Ala 
    530                 535                 540                 


Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu Val 
545                 550                 555                 560 


Lys Pro Asn Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg Ile 
                565                 570                 575     


Lys Ile Glu Lys Gln Phe Lys Ala Ile Asn His Pro Ser Lys Asn Asn 
            580                 585                 590         


Lys Gly Ile Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val Asn 
        595                 600                 605             


Ala Ile Lys Leu Lys Lys Asp Leu Glu Ala Glu Leu Asp Met Leu Asn 
    610                 615                 620                 


Lys Lys His Ile Ala Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn Tyr 
625                 630                 635                 640 


Asp Lys Leu Leu Lys Glu His Gln Phe Thr Pro Lys Asn Lys Arg Pro 
                645                 650                 655     


Glu Leu Arg Lys Tyr Val Phe Tyr Lys Ser Glu Lys Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Asp Phe Lys 
        675                 680                 685             


Thr Lys Trp Lys Gly Cys Gln His Ser Glu Leu Gln Arg Lys Leu Ala 
    690                 695                 700                 


Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser Gly 
705                 710                 715                 720 


Cys Glu Phe Asp His Ser Leu Leu Asp Ile Asn Ala Tyr Phe Gln Lys 
                725                 730                 735     


Asp Asn Phe Glu Asp Phe Phe Ser Lys Tyr Leu Glu Asn Arg Ile Glu 
            740                 745                 750         


Thr Leu Glu Gly Val Leu Lys Lys Leu His Asp Phe Lys Asn Glu Pro 
        755                 760                 765             


Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Phe Lys Phe Leu Lys Arg 
    770                 775                 780                 


Gln Asn Tyr Val Thr Glu Ser Pro Glu Ile Ile Lys Lys Arg Ile Leu 
785                 790                 795                 800 


Ala Lys Pro Thr Phe Leu Pro Arg Gly Val Phe Asp Glu Arg Pro Thr 
                805                 810                 815     


Met Lys Lys Gly Lys Asn Pro Leu Lys Asp Lys Asn Glu Phe Ala Glu 
            820                 825                 830         


Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr Asn 
        835                 840                 845             


Ala Glu Glu Tyr Arg Met Arg Asp Ala Asp Phe Lys Lys Asn Ala Val 
    850                 855                 860                 


Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val Asn 
865                 870                 875                 880 


Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln Leu 
                885                 890                 895     


Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly Ile 
            900                 905                 910         


Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn Thr 
        915                 920                 925             


Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe Phe 
    930                 935                 940                 


Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly Lys 
945                 950                 955                 960 


Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly Tyr 
                965                 970                 975     


Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys Asp 
            980                 985                 990         


Arg Tyr Ser Val Lys Pro Ile Asn  Val Ile Asp Leu Gln  Ile Gln Glu 
        995                 1000                 1005             


Tyr Glu  Glu Ile Arg Ser His  Glu Leu Leu Lys Glu  Ile Gln Asn 
    1010                 1015                 1020             


Leu Glu  Gln Tyr Ile Tyr Asp  His Thr Thr Asp Lys  Asn Ile Leu 
    1025                 1030                 1035             


Leu Gln  Asp Gly Asn Pro Asn  Phe Lys Met Tyr Val  Leu Asn Gly 
    1040                 1045                 1050             


Leu Leu  Ile Gly Ile Lys Gln  Val Asn Ile Pro Asp  Phe Ile Val 
    1055                 1060                 1065             


Leu Lys  Gln Asn Thr Asn Phe  Asp Lys Ile Asp Phe  Thr Gly Ile 
    1070                 1075                 1080             


Ala Ser  Cys Ser Glu Leu Glu  Lys Lys Thr Ile Ile  Leu Ile Ala 
    1085                 1090                 1095             


Ile Arg  Asn Lys Phe Ala His  Asn Gln Leu Pro Asn  Lys Met Ile 
    1100                 1105                 1110             


Tyr Asp  Leu Ala Asn Glu Phe  Leu Lys Ile Glu Lys  Asn Glu Thr 
    1115                 1120                 1125             


Tyr Ala  Asn Tyr Tyr Leu Lys  Val Leu Lys Lys Met  Ile Ser Asp 
    1130                 1135                 1140             


Leu Ala  
    1145 


<210> 25
<211> 1147
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 25
Met Glu Asp Lys Thr Thr Gly Ala Gly Ile Ser Tyr Asp His Thr Leu 
1               5                   10                  15      


Met Glu Asp Lys His Phe Phe Gly Gly Phe Leu Asn Leu Ala Gln Asn 
            20                  25                  30          


Asn Ile Asp Ala Leu Leu Lys Ala Phe Lys Glu Arg Phe Asn Val Arg 
        35                  40                  45              


Tyr Gln Ser Lys Gln Phe Ala Glu Val Cys Phe Ser Asp Lys Leu Pro 
    50                  55                  60                  


Asp Gln Asp Tyr Leu Asp Arg Thr Leu Phe Leu Glu Thr His Leu Pro 
65                  70                  75                  80  


Phe Ile Lys Tyr Ile Gly Gly Lys Glu Ala Asn Asn Arg Gly Thr Phe 
                85                  90                  95      


Arg Lys Asn Ile Thr Leu Phe Phe Glu Ser Ile Glu Gln Leu Arg Asn 
            100                 105                 110         


Phe Tyr Thr His Tyr Tyr His Lys Pro Ile Leu Phe Pro Glu Glu Leu 
        115                 120                 125             


Tyr Glu Asn Leu Asp Arg Ile Phe Val Glu Val Ser Lys Glu Val Lys 
    130                 135                 140                 


Thr His Lys Val Lys Asn Asp Gln Thr Arg His Leu Leu Thr Lys Asn 
145                 150                 155                 160 


Leu Ala Asn Glu Leu Asp Ile Arg Tyr Lys Lys Asn Val Glu Lys Leu 
                165                 170                 175     


Lys Glu Leu Lys Ala Gln Gly Lys Lys Val Asn Ile His Asp Lys Glu 
            180                 185                 190         


Ala Ile Lys Asn Ser Val Leu Asn Asn Ala Phe Asn His Leu Ile Tyr 
        195                 200                 205             


Lys Lys Glu Glu Asp Val Phe Ala Thr Glu Ala Tyr Lys Ser Lys Tyr 
    210                 215                 220                 


Asn Leu Glu Asp Pro Ser Lys Asn Gly Ile Ser Leu Ser Gln Ser Gly 
225                 230                 235                 240 


Leu Leu Phe Leu Leu Ser Met Phe Leu Asn Lys Lys Asp Ile Glu Ala 
                245                 250                 255     


Leu Lys Ser Arg Val Lys Gly Phe Lys Ala Lys Ile Ile Arg Asp Gly 
            260                 265                 270         


Glu Glu Asn Ile Ser Gly Leu Lys Phe Met Ala Thr His Trp Val Phe 
        275                 280                 285             


Ser Ser Leu Ser Phe Lys Asn Val Lys His Lys Leu Ser Thr Asp Phe 
    290                 295                 300                 


His Lys Glu Thr Leu Leu Ile Gln Ile Val Asp Glu Leu Ser Lys Val 
305                 310                 315                 320 


Pro Asp Glu Val Tyr Lys Thr Phe Asp Lys Gln Thr Gln Glu Glu Phe 
                325                 330                 335     


Ile Glu Asp Ile Asn Glu Tyr Met Lys Val Gly Asn Lys Asp Leu Ser 
            340                 345                 350         


Leu Glu Glu Ser Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Asp 
        355                 360                 365             


Asn Lys Phe Asn Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Ala Gly 
    370                 375                 380                 


Phe Pro Thr Leu Arg Phe Gln Val His Ile Gly Asn Tyr Ile His Asp 
385                 390                 395                 400 


Arg Arg Ile Lys Asn Ile Asp Gly Thr Ala Phe Gln Thr Glu Arg Ser 
                405                 410                 415     


Val Lys Glu Arg Ile Lys Val Phe Gly Lys Leu Ser Gln Met Ser Asn 
            420                 425                 430         


Leu Lys Ala Glu Tyr Val Ser Gly Leu Met Asp Glu Pro Val Asp Thr 
        435                 440                 445             


Gly Trp Glu Ile Phe Pro Asn Pro Ser Tyr Asn Ile Ile Glu Asn Asn 
    450                 455                 460                 


Ile Pro Ile Tyr Ile Glu Met Gly Asp His Phe Asn Asp Glu Val Leu 
465                 470                 475                 480 


Gln Ser Lys Met Ala Arg Lys Lys Gln Lys Pro Glu Glu Leu Lys Asp 
                485                 490                 495     


Arg Asn Ser Ala Lys Ala Ser Lys Glu Ser Met Ile Gln Thr Leu Gln 
            500                 505                 510         


Asn Asp Lys Gly Leu Met Asp Val Ile Thr Val Ser Pro Thr Ala Gln 
        515                 520                 525             


Leu Ser Leu Asn Glu Leu Pro Ala Ile Leu Tyr Glu Leu Leu Val Lys 
    530                 535                 540                 


Lys Thr Pro Ala Lys Thr Ile Glu Lys Lys Leu Val Gly Lys Leu Asn 
545                 550                 555                 560 


Gln Arg Leu Lys Glu Ile Lys Asn Tyr Asn Pro Glu Lys Pro Leu Pro 
                565                 570                 575     


Ala Ser Gln Ile Ser Lys Arg Leu Arg Leu Asn Arg Glu Glu Gly Ser 
            580                 585                 590         


Ile Asn Thr Lys Lys Ile Ile Ala Leu Leu Gln Lys Glu Leu Asn Tyr 
        595                 600                 605             


Thr Gln Glu Lys Leu Asp Leu Leu Glu Lys Asn Arg Lys Glu Tyr Gly 
    610                 615                 620                 


Lys Lys Val Asp Gly Lys Ile Leu Arg Lys Tyr Val Phe Gly Leu Lys 
625                 630                 635                 640 


Glu Ile Gly Asn Leu Ala Thr Asp Met Ala Met Asp Ile Lys Arg Phe 
                645                 650                 655     


Met Pro Ala Asn Val Arg Lys Glu Trp Lys Gly Tyr Gln His Ser Gln 
            660                 665                 670         


Leu Gln Gln Ser Leu Ala Phe Tyr Asp Lys Arg Pro Glu Glu Ala Phe 
        675                 680                 685             


Asn Ile Leu Gln Glu Val Trp Asp Ile Asn Arg Glu Lys Ser Leu Trp 
    690                 695                 700                 


Asp Thr Trp Ile Leu Asn Ala Phe Gln Thr Ser Gly Asn Phe Glu Arg 
705                 710                 715                 720 


Phe Phe Glu Leu Tyr His Glu Gly Arg Lys Lys Tyr Ile Gln Gln Gln 
                725                 730                 735     


Leu Glu Asn Ile Asp Arg Tyr Thr Asp Asn Lys Lys Phe Leu Gln Lys 
            740                 745                 750         


Phe Ile Asn Gln Gln Phe Pro Thr Asn Phe Leu Glu Lys Arg Leu Tyr 
        755                 760                 765             


Thr Leu Glu Ser Leu Glu Ile Glu Lys Leu Lys Ile Leu Ser Lys Pro 
    770                 775                 780                 


Phe Ile Leu Pro Arg Gly Thr Phe Asp Glu Lys Pro Thr Phe Ile Met 
785                 790                 795                 800 


Gly Glu Lys Val Thr Glu Asn Pro Glu Leu Phe Ala Asp Trp Tyr Thr 
                805                 810                 815     


Tyr Gly Tyr Gln Gln His Glu Phe Gln Lys Phe Tyr Ser Trp Pro Arg 
            820                 825                 830         


Asp Tyr Lys Asp Leu Leu Gln Asn Glu Gln Lys Arg Asp Pro Asp Phe 
        835                 840                 845             


Ala Glu Asn Lys Lys Gly Leu Ser Asp Leu Lys Gln Leu Glu Leu Leu 
    850                 855                 860                 


Gln Leu Lys Gln Asp Ile Ile Ile Lys Lys Ile Lys Thr Gln Asp Leu 
865                 870                 875                 880 


Tyr Leu Lys Leu Ile Met Asp Ala Leu Phe Ile Glu Val Phe Gly Gln 
                885                 890                 895     


Glu Ala Asp Ile Ser Leu Asn Asp Leu Tyr Leu Thr Gln Glu Glu Arg 
            900                 905                 910         


Leu Glu Lys Glu Lys Leu Ala Leu Lys Gln His Gln Arg Val Glu Gly 
        915                 920                 925             


Asp Asp Ser Pro Asn Val Ile Lys Asp Asn Phe Ile Trp Ser Lys Thr 
    930                 935                 940                 


Met Pro Tyr Lys His Asp Lys Ile Tyr Glu Pro Gln Val Arg Leu Lys 
945                 950                 955                 960 


Asp Phe Gly Lys Phe Lys His Phe Leu Leu Asp Asp Lys Val Ala Lys 
                965                 970                 975     


Ile Leu Ser Tyr Asp Leu Gln Glu Thr Trp Asn Lys Asn Glu Leu Glu 
            980                 985                 990         


Ile Gln Ile Asn Thr Gly Gln Asp  Ser Tyr Glu Val Ile  Arg Arg Glu 
        995                 1000                 1005             


Glu Leu  Leu Lys Glu Ile Gln  Leu Leu Glu Lys Gln  Ile Leu Glu 
    1010                 1015                 1020             


Thr Phe  Ser His Thr Leu Asp  Glu His Pro Lys Glu  Phe Glu Asp 
    1025                 1030                 1035             


Glu Lys  Gly Asn Pro Asn Phe  Lys Met Tyr Met Ala  Asn Gly Val 
    1040                 1045                 1050             


Ile Arg  Lys Gly Ser Ser Thr  Thr Ala Lys Asp Glu  Ala Asp Trp 
    1055                 1060                 1065             


Leu Glu  His Glu Lys Asp Phe  Asp Asn Leu Ser Leu  Glu Ile Phe 
    1070                 1075                 1080             


Asn Ser  Lys Ser Glu Ile Thr  Gln Leu Thr Phe Leu  Ile Val Leu 
    1085                 1090                 1095             


Ile Arg  Asn Lys Phe Gly His  Asn Gln Leu Pro Ile  Lys Gln Phe 
    1100                 1105                 1110             


Tyr Glu  Ile Ile Gln Asn Glu  Tyr Ser Ile Thr Gly  Glu Thr Ile 
    1115                 1120                 1125             


Ser Arg  Leu Tyr Leu Asn Phe  Ile Ile Tyr Ala Lys  Ala Arg Leu 
    1130                 1135                 1140             


Lys Asp  Leu Met 
    1145         


<210> 26
<211> 1133
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 26
Met Glu Glu Lys Leu Gly Lys Gly Val Glu Tyr Asn Pro Phe Lys Lys 
1               5                   10                  15      


Glu Asp Lys Tyr Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Glu Asn Asn 
            20                  25                  30          


Ile Asn Glu Val Phe Lys Glu Val Lys Lys Arg Leu Gly Glu Thr Asn 
        35                  40                  45              


Ser Ser Ser Asn Ile Glu Leu Leu Asn Asn Val Phe Arg Lys Glu Met 
    50                  55                  60                  


Ser Leu Val Asp Tyr Glu Lys Trp Val Asn Ala Phe Ala Asp Tyr Phe 
65                  70                  75                  80  


Pro Ile Val Asn Tyr Leu Asp Arg Glu Thr Ile Lys Lys Gly Glu Lys 
                85                  90                  95      


Val Val Glu Val Pro Arg Glu Lys Arg Ile Glu Cys Phe Arg Asp Met 
            100                 105                 110         


Phe Lys Gly Leu Ile Asn Thr Ile Ser Gln Leu Arg His Tyr Tyr Thr 
        115                 120                 125             


His Tyr His His Glu Pro Ile Glu Ile Asp Asp Lys Ile Leu Ser Phe 
    130                 135                 140                 


Leu Asp Glu Val Leu Phe Asn Thr Ile Ile Thr Thr Lys Asn Lys Tyr 
145                 150                 155                 160 


Leu Lys Thr Asp Lys Thr Lys Glu Leu Ile Lys Asp Ser Leu Gln Glu 
                165                 170                 175     


Glu Leu Asp Ile Leu Cys Lys Leu Lys Val Lys Tyr Leu Glu Ser Lys 
            180                 185                 190         


Arg Lys Arg Phe Asp Arg Lys Asp Lys Gly Ala Ile Glu Asn Ala Val 
        195                 200                 205             


Tyr Asn Asp Val Phe Arg Arg Phe Ile Tyr Lys Asp Glu Lys Gly Asn 
    210                 215                 220                 


Glu Ser Leu Lys Asp Ile Ile Arg Thr Lys Gln Ile Lys Val His Gln 
225                 230                 235                 240 


Asn Ser Ser Tyr Leu Glu Leu Pro Ile Ser Ser Ser Gly Ile Ile Phe 
                245                 250                 255     


Leu Leu Ser Leu Phe Leu Asn Lys Lys Glu Val Glu Ser Leu Lys Ser 
            260                 265                 270         


Asn Ile Arg Gly Tyr Lys Gly Lys Ser Lys Ser Glu Glu Thr Thr Pro 
        275                 280                 285             


Glu Lys Asn Gly Leu Leu Phe Met Thr Thr His Arg Ile Tyr Ser Val 
    290                 295                 300                 


Leu Ala Tyr Lys Gly Leu Lys Lys Arg Ile Lys Thr Ser Val Lys Gly 
305                 310                 315                 320 


Asp Lys Glu Thr Leu Leu Met Gln Met Ile Asp Glu Val Ser Lys Val 
                325                 330                 335     


Pro His Cys Ile Tyr Gln Asn Leu Asp Gln Thr Leu Gln Ala Thr Phe 
            340                 345                 350         


Ile Glu Asp Trp Asn Glu Tyr Phe Lys Asp Asn Glu Glu Asn Glu Glu 
        355                 360                 365             


Asn Leu Glu Asn Ser Arg Val Leu His Pro Val Ile Arg Lys Arg Tyr 
    370                 375                 380                 


Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Tyr Ala 
385                 390                 395                 400 


Glu Phe Pro Ser Leu Arg Phe Gln Val Asn Leu Gly Asn Tyr Val His 
                405                 410                 415     


His Lys Ala Thr Lys Lys Phe Gly Asn Ser Glu Val Thr Thr Glu Arg 
            420                 425                 430         


Val Ile Lys Asp Lys Ile Thr Val Phe Gly Arg Leu Ser Glu Val Asn 
        435                 440                 445             


Lys Ala Lys Ala Asp Phe Phe Lys Asn Glu Thr Glu Leu Asp Pro Ala 
    450                 455                 460                 


Trp Glu Leu Phe Pro Asn Pro Ser Tyr Glu Phe Pro Lys Glu Lys Gly 
465                 470                 475                 480 


Asn Asn Asp Lys Asp Ala Gly Lys Ile Gly Ile Gln Val Lys Leu Leu 
                485                 490                 495     


Asn Lys Asp Ile Glu Ala Val Leu Asn Glu Ser Lys Asn Thr Leu Asn 
            500                 505                 510         


Asn Lys Thr Arg Lys Ser Asp Lys Ile Ser Lys Lys Glu Ile Ile Asn 
        515                 520                 525             


Lys Ile Val Gln Ile Asn Asp Asp Thr Lys Tyr Asn Asn Lys Asn Ile 
    530                 535                 540                 


Ile Tyr Gln Gly Asn Ala Ile Ala Tyr Leu Ser Leu Asn Asp Ile His 
545                 550                 555                 560 


Ser Leu Leu Tyr Glu Leu Leu Val Ile Gly Thr Lys Gly Asp Lys Leu 
                565                 570                 575     


Glu Arg Lys Val Val Glu Lys Ile Gln Gln Gln Val Thr Glu Ile Arg 
            580                 585                 590         


Asn Lys Asp Thr Ser Ala Lys Ile Leu Ser Lys Tyr Lys Asp Ser Glu 
        595                 600                 605             


Glu Ser Asn Thr Ile Asp Lys Lys Lys Leu Val Ile Asp Leu Lys Tyr 
    610                 615                 620                 


Glu Tyr Asp Lys Leu Gln Asp Leu Leu Lys Glu His Lys Asn Arg Glu 
625                 630                 635                 640 


Glu Asp Tyr Ile Gln Thr Lys Lys Lys Lys Lys Asp Ser Pro Lys Arg 
                645                 650                 655     


Lys Tyr Ile Leu Tyr His Asn Glu Lys Gly Gln Val Ala Val Trp Leu 
            660                 665                 670         


Ser Asn Asp Ile Lys Arg Phe Met Pro Gln Asn Phe Lys Glu Lys Trp 
        675                 680                 685             


Lys Gly Tyr Gln His Ser Glu Phe Gln Lys Ser Leu Ala Tyr Tyr Glu 
    690                 695                 700                 


Thr Asn Lys Glu Met Leu Lys Ile Ile Leu Gln Asp Leu Asp Leu Glu 
705                 710                 715                 720 


Gln Phe Pro Phe Asp Ile Lys Ser Cys Phe Tyr Lys Asn Thr Leu Glu 
                725                 730                 735     


Asp Phe Tyr Asn Arg Tyr Leu Ser Leu Arg Ile Ser Tyr Leu Glu Asn 
            740                 745                 750         


Val Ile Asp Arg Val Glu Cys Phe Ser Asn Glu Pro Lys Ala Phe Lys 
        755                 760                 765             


Ser Val Leu Lys Glu Cys Phe Val Phe Leu Lys Lys Gln Asn Tyr Thr 
    770                 775                 780                 


Asn His Ser Leu Asp Glu Gln Val Lys Lys Ile Leu Ala Asn Pro Ile 
785                 790                 795                 800 


Phe Ile Glu Arg Gly Phe Leu Asp Thr Lys Pro Thr Met Ile Gln Gly 
                805                 810                 815     


Val Lys Phe Ser Glu Asn Lys Gly Cys Phe Ala Asp Trp Phe Val His 
            820                 825                 830         


Tyr Lys Glu Tyr Glu His Tyr Gln Lys Phe Tyr Asp Thr Asn Leu Tyr 
        835                 840                 845             


Pro Val Glu Ser Ile Glu Asp Lys Glu Arg Gln Lys Leu Glu Ala Thr 
    850                 855                 860                 


Ile Lys Lys Gln Gln Lys Asn Asp Val Phe Thr Leu Leu Met Ile Lys 
865                 870                 875                 880 


Lys Ile Phe Asn Asp Leu Phe Asn Gln Asp Phe Glu Ala Asn Leu Tyr 
                885                 890                 895     


Glu Met Tyr Gln Ser Lys Glu Glu Arg Glu Lys Asn Gln Leu Val Ala 
            900                 905                 910         


Lys Glu Thr Gln Asn Arg Asn Leu Asn Phe Ile Trp Asn Lys Pro Ile 
        915                 920                 925             


Ala Ile Asp Leu Phe Asp Gly Lys Val Lys Ile Asp Glu Val Lys Leu 
    930                 935                 940                 


Lys Asp Val Gly Ser Phe Arg Lys Tyr Glu Asn Asp Lys Arg Val Gln 
945                 950                 955                 960 


Thr Phe Ile Thr Tyr Ile Pro Glu Ile Gln Trp Ile Pro Tyr Leu Pro 
                965                 970                 975     


Asn Thr Trp Glu Gly Ile Asn Leu Pro Val Asn Val Ile Glu Arg Gln 
            980                 985                 990         


Ile Asp Arg Tyr Glu Lys Val Arg  Ser Glu Glu Leu Leu  Lys Glu Val 
        995                 1000                 1005             


Gln Ala  Ile Glu Lys Tyr Ile  Tyr Glu Gln Val Asn  Asp Lys Thr 
    1010                 1015                 1020             


Glu Leu  Leu Gln Asn Gly Asn  Gln Asn Phe Lys Asn  Tyr Leu Val 
    1025                 1030                 1035             


Asn Gly  Leu Leu Lys Gln Ile  Gln Gly Ile Asp Val  Ser Asn Phe 
    1040                 1045                 1050             


Lys Phe  Ile Asn Gln Gln Lys  Phe Glu Thr Ile Asn  Val Lys Asp 
    1055                 1060                 1065             


Leu Asp  Asn Glu Ala Ser Ala  Leu Glu Gln Lys Val  Tyr Val Leu 
    1070                 1075                 1080             


Ile Asn  Ile Arg Asn Gln Phe  Ser His Asn Gln Phe  Pro Lys Ser 
    1085                 1090                 1095             


Ala Phe  Tyr Gln Phe Cys Gln  Lys Ile Leu Ser Ile  Glu Glu Asp 
    1100                 1105                 1110             


Glu Leu  Phe Ala Asp Tyr Tyr  Leu Arg Leu Phe Lys  Leu Leu Arg 
    1115                 1120                 1125             


Asn Glu  Leu Leu Asp 
    1130             


<210> 27
<211> 1156
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 27
Met Asn Thr Arg Val Thr Gly Met Gly Val Ser Tyr Asp His Thr Lys 
1               5                   10                  15      


Lys Glu Asp Lys His Phe Phe Gly Gly Phe Leu Asn Leu Ala Gln Asp 
            20                  25                  30          


Asn Ile Thr Ala Val Ile Lys Ala Phe Cys Ile Lys Phe Asp Lys Asn 
        35                  40                  45              


Pro Met Ser Ser Val Gln Phe Ala Glu Ser Cys Phe Thr Asp Lys Asp 
    50                  55                  60                  


Ser Asp Thr Asp Phe Gln Asn Lys Val Arg Tyr Val Arg Thr His Leu 
65                  70                  75                  80  


Pro Val Ile Gly Tyr Leu Asn Tyr Gly Gly Asp Arg Asn Thr Phe Arg 
                85                  90                  95      


Gln Lys Leu Ser Thr Leu Leu Lys Ala Val Asp Ser Leu Arg Asn Phe 
            100                 105                 110         


Tyr Thr His Tyr Tyr His Ser Pro Leu Ala Leu Ser Thr Glu Leu Phe 
        115                 120                 125             


Glu Leu Leu Asp Thr Val Phe Ala Ser Val Ala Val Glu Val Lys Gln 
    130                 135                 140                 


His Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Ser Lys Ser Leu 
145                 150                 155                 160 


Ala Glu Glu Leu Asp Ile Arg Tyr Lys Gln Gln Leu Glu Arg Leu Lys 
                165                 170                 175     


Glu Leu Lys Glu Gln Gly Lys Asn Ile Asp Leu Arg Asp Glu Ala Gly 
            180                 185                 190         


Ile Arg Asn Gly Val Leu Asn Ala Ala Phe Asn His Leu Ile Tyr Lys 
        195                 200                 205             


Glu Gly Glu Ile Ala Lys Pro Thr Leu Ser Tyr Ser Ser Phe Tyr Tyr 
    210                 215                 220                 


Gly Ala Asp Ser Ala Glu Asn Gly Ile Thr Ile Ser Gln Ser Gly Leu 
225                 230                 235                 240 


Leu Phe Leu Leu Ser Met Phe Leu Gly Lys Lys Glu Ile Glu Asp Leu 
                245                 250                 255     


Lys Ser Arg Ile Arg Gly Phe Lys Ala Lys Ile Val Arg Asp Gly Glu 
            260                 265                 270         


Glu Asn Ile Ser Gly Leu Lys Phe Met Ala Thr His Trp Ile Phe Ser 
        275                 280                 285             


Tyr Leu Ser Phe Lys Gly Met Lys Gln Arg Leu Ser Thr Asp Phe His 
    290                 295                 300                 


Glu Glu Thr Leu Leu Ile Gln Ile Ile Asp Glu Leu Ser Lys Val Pro 
305                 310                 315                 320 


Asp Glu Val Tyr His Asp Phe Asp Thr Ala Thr Arg Glu Lys Phe Val 
                325                 330                 335     


Glu Asp Ile Asn Glu Tyr Ile Arg Glu Gly Asn Glu Asp Phe Ser Leu 
            340                 345                 350         


Gly Asp Ser Thr Ile Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn 
        355                 360                 365             


Lys Phe Asn Tyr Phe Ala Val Arg Phe Leu Asp Glu Phe Ile Lys Phe 
    370                 375                 380                 


Pro Ser Leu Arg Phe Gln Val His Leu Gly Asn Phe Val His Asp Arg 
385                 390                 395                 400 


Arg Ile Lys Asp Ile His Gly Thr Gly Phe Gln Thr Glu Arg Val Val 
                405                 410                 415     


Lys Asp Arg Ile Lys Val Phe Gly Lys Leu Ser Glu Ile Ser Ser Leu 
            420                 425                 430         


Lys Thr Glu Tyr Ile Glu Lys Glu Leu Asp Leu Asp Ser Asp Thr Gly 
        435                 440                 445             


Trp Glu Ile Phe Pro Asn Pro Ser Tyr Val Phe Ile Asp Asn Asn Ile 
    450                 455                 460                 


Pro Ile Tyr Ile Ser Thr Asn Lys Thr Phe Lys Asn Gly Ser Ser Glu 
465                 470                 475                 480 


Phe Ile Lys Leu Arg Arg Lys Glu Lys Pro Glu Glu Met Lys Met Arg 
                485                 490                 495     


Gly Glu Asp Lys Lys Glu Lys Arg Asp Ile Ala Ser Met Ile Gly Asn 
            500                 505                 510         


Ala Gly Ser Leu Asn Ser Lys Thr Pro Leu Ala Met Leu Ser Leu Asn 
        515                 520                 525             


Glu Met Pro Ala Leu Leu Tyr Glu Ile Leu Val Lys Lys Thr Thr Pro 
    530                 535                 540                 


Glu Glu Ile Glu Leu Ile Ile Lys Glu Lys Leu Asp Ser His Phe Glu 
545                 550                 555                 560 


Asn Ile Lys Asn Tyr Asp Pro Glu Lys Pro Leu Pro Ala Ser Gln Ile 
                565                 570                 575     


Ser Lys Arg Leu Arg Asn Asn Thr Thr Asp Lys Gly Lys Lys Val Ile 
            580                 585                 590         


Asn Pro Glu Lys Leu Ile His Leu Ile Asn Lys Glu Ile Asp Ala Thr 
        595                 600                 605             


Glu Ala Lys Phe Ala Leu Leu Ala Lys Asn Arg Lys Glu Leu Lys Glu 
    610                 615                 620                 


Lys Phe Arg Gly Lys Pro Leu Arg Gln Thr Ile Phe Ser Asn Met Glu 
625                 630                 635                 640 


Leu Gly Arg Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe Met 
                645                 650                 655     


Pro Asp Ile Leu Arg Lys Asn Trp Lys Gly Tyr Gln His Asn Gln Leu 
            660                 665                 670         


Gln Gln Ser Leu Ala Phe Phe Asn Ser Arg Pro Lys Glu Ala Phe Thr 
        675                 680                 685             


Ile Leu Gln Asp Gly Trp Asp Phe Ala Asp Gly Ser Ser Phe Trp Asn 
    690                 695                 700                 


Gly Trp Ile Ile Asn Ser Phe Val Lys Asn Arg Ser Phe Glu Tyr Phe 
705                 710                 715                 720 


Tyr Glu Ala Tyr Phe Glu Gly Arg Lys Glu Tyr Phe Ser Ser Leu Ala 
                725                 730                 735     


Glu Asn Ile Lys Gln His Thr Ser Asn His Arg Asn Leu Arg Arg Phe 
            740                 745                 750         


Ile Asp Gln Gln Met Pro Lys Gly Leu Phe Glu Asn Arg His Tyr Leu 
        755                 760                 765             


Leu Glu Asn Leu Glu Thr Glu Lys Asn Lys Ile Leu Ser Lys Pro Leu 
    770                 775                 780                 


Val Phe Pro Arg Gly Leu Phe Asp Thr Lys Pro Thr Phe Ile Lys Gly 
785                 790                 795                 800 


Ile Lys Val Asp Glu Gln Pro Glu Leu Phe Ala Glu Trp Tyr Gln Tyr 
                805                 810                 815     


Gly Tyr Ser Thr Glu His Val Phe Gln Asn Phe Tyr Gly Trp Glu Arg 
            820                 825                 830         


Asp Tyr Asn Asp Leu Leu Glu Ser Glu Leu Glu Lys Asp Asn Asp Phe 
        835                 840                 845             


Ser Lys Asn Ser Ile His Tyr Ser Arg Thr Ser Gln Leu Glu Leu Ile 
    850                 855                 860                 


Lys Leu Lys Gln Asp Leu Lys Ile Lys Lys Ile Lys Ile Gln Asp Leu 
865                 870                 875                 880 


Phe Leu Lys Leu Ile Ala Gly His Ile Phe Glu Asn Ile Phe Lys Tyr 
                885                 890                 895     


Pro Ala Ser Phe Ser Leu Asp Glu Leu Tyr Leu Thr Gln Glu Glu Arg 
            900                 905                 910         


Leu Asn Lys Glu Gln Glu Ala Leu Ile Gln Ser Gln Arg Lys Glu Gly 
        915                 920                 925             


Asp His Ser Asp Asn Ile Ile Lys Asp Asn Phe Ile Gly Ser Lys Thr 
    930                 935                 940                 


Val Thr Tyr Glu Ser Lys Gln Ile Ser Glu Pro Asn Val Lys Leu Lys 
945                 950                 955                 960 


Asp Ile Gly Lys Phe Asn Arg Phe Leu Leu Asp Asp Lys Val Lys Thr 
                965                 970                 975     


Leu Leu Ser Tyr Asn Glu Asp Lys Val Trp Asn Lys Asn Asp Leu Asp 
            980                 985                 990         


Leu Glu Leu Ser Ile Gly Glu Asn  Ser Tyr Glu Val Ile  Arg Arg Glu 
        995                 1000                 1005             


Lys Leu  Phe Lys Lys Ile Gln  Asn Phe Glu Leu Gln  Thr Leu Thr 
    1010                 1015                 1020             


Asp Trp  Pro Trp Asn Gly Thr  Asp His Pro Glu Glu  Phe Gly Thr 
    1025                 1030                 1035             


Thr Asp  Asn Lys Gly Val Asn  His Pro Asn Phe Lys  Met Tyr Val 
    1040                 1045                 1050             


Val Asn  Gly Ile Leu Arg Lys  His Thr Asp Trp Phe  Lys Glu Gly 
    1055                 1060                 1065             


Glu Asp  Asn Trp Leu Glu Asn  Leu Asn Glu Thr His  Phe Lys Asn 
    1070                 1075                 1080             


Leu Ser  Phe Gln Glu Leu Glu  Thr Lys Ser Lys Ser  Ile Gln Thr 
    1085                 1090                 1095             


Ala Phe  Leu Ile Ile Met Ile  Arg Asn Gln Phe Ala  His Asn Gln 
    1100                 1105                 1110             


Leu Pro  Ala Val Gln Phe Phe  Glu Phe Ile Gln Lys  Lys Tyr Pro 
    1115                 1120                 1125             


Glu Ile  Gln Gly Ser Thr Thr  Ser Glu Leu Tyr Leu  Asn Phe Ile 
    1130                 1135                 1140             


Asn Leu  Ala Val Val Glu Leu  Leu Glu Leu Leu Glu  Lys 
    1145                 1150                 1155     


<210> 28
<211> 1036
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 28
Met Glu Thr Gln Ile Leu Gly Asn Gly Ile Ser Tyr Asp His Thr Lys 
1               5                   10                  15      


Thr Glu Asp Lys His Phe Phe Gly Gly Phe Leu Asn Thr Ala Gln Asn 
            20                  25                  30          


Asn Ile Asp Leu Leu Ile Lys Ala Tyr Ile Ser Lys Phe Glu Ser Ser 
        35                  40                  45              


Pro Arg Lys Leu Asn Ser Val Gln Phe Pro Asp Val Cys Phe Lys Lys 
    50                  55                  60                  


Asn Asp Ser Asp Ala Asp Phe Gln His Lys Leu Gln Phe Ile Arg Lys 
65                  70                  75                  80  


His Leu Pro Val Ile Gln Tyr Leu Lys Tyr Gly Gly Asn Arg Glu Val 
                85                  90                  95      


Leu Lys Glu Lys Phe Arg Leu Leu Leu Gln Ala Val Asp Ser Leu Arg 
            100                 105                 110         


Asn Phe Tyr Thr His Phe Tyr His Lys Pro Ile Gln Leu Pro Asn Glu 
        115                 120                 125             


Leu Leu Thr Leu Leu Asp Thr Ile Phe Gly Glu Ile Gly Asn Glu Val 
    130                 135                 140                 


Arg Gln Asn Lys Met Lys Asp Asp Lys Thr Arg His Leu Leu Lys Lys 
145                 150                 155                 160 


Asn Leu Ser Glu Glu Leu Asp Phe Arg Tyr Gln Glu Gln Leu Glu Arg 
                165                 170                 175     


Leu Arg Lys Leu Lys Ser Glu Gly Lys Lys Val Asp Leu Arg Asp Thr 
            180                 185                 190         


Glu Ala Ile Arg Asn Gly Val Leu Asn Ala Ala Phe Asn His Leu Ile 
        195                 200                 205             


Phe Lys Asp Ala Glu Asp Phe Lys Pro Thr Val Ser Tyr Ser Ser Tyr 
    210                 215                 220                 


Tyr Tyr Asp Ser Asp Thr Ala Glu Asn Gly Ile Ser Ile Ser Gln Ser 
225                 230                 235                 240 


Gly Leu Leu Phe Leu Leu Ser Met Phe Leu Gly Arg Arg Glu Met Glu 
                245                 250                 255     


Asp Leu Lys Ser Arg Val Arg Gly Phe Lys Ala Arg Ile Ile Lys His 
            260                 265                 270         


Glu Glu Gln His Val Ser Gly Leu Lys Phe Met Ala Thr His Trp Val 
        275                 280                 285             


Phe Ser Glu Phe Cys Phe Lys Gly Ile Lys Thr Arg Leu Asn Ala Asp 
    290                 295                 300                 


Tyr His Glu Glu Thr Leu Leu Ile Gln Leu Ile Asp Glu Leu Ser Lys 
305                 310                 315                 320 


Val Pro Asp Glu Leu Tyr Arg Ser Phe Asp Val Ala Thr Arg Glu Arg 
                325                 330                 335     


Phe Ile Glu Asp Ile Asn Glu Tyr Ile Arg Asp Gly Lys Glu Asp Lys 
            340                 345                 350         


Ser Leu Ile Glu Ser Lys Ile Val His Pro Val Ile Arg Lys Arg Tyr 
        355                 360                 365             


Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Val 
    370                 375                 380                 


Asn Phe Pro Thr Leu Arg Phe Gln Val His Ala Gly Asn Tyr Val His 
385                 390                 395                 400 


Asp Arg Arg Ile Lys Ser Ile Glu Gly Thr Gly Phe Lys Thr Glu Arg 
                405                 410                 415     


Leu Val Lys Asp Arg Ile Lys Val Phe Gly Lys Leu Ser Thr Ile Ser 
            420                 425                 430         


Ser Leu Lys Ala Glu Tyr Leu Ala Lys Ala Val Asn Ile Thr Asp Asp 
        435                 440                 445             


Thr Gly Trp Glu Leu Leu Pro His Pro Ser Tyr Val Phe Ile Asp Asn 
    450                 455                 460                 


Asn Ile Pro Ile His Leu Thr Val Asp Pro Ser Phe Lys Asn Gly Val 
465                 470                 475                 480 


Lys Glu Tyr Gln Glu Lys Arg Lys Leu Gln Lys Pro Glu Glu Met Lys 
                485                 490                 495     


Asn Arg Gln Gly Gly Asp Lys Met His Lys Pro Ala Ile Ser Ser Lys 
            500                 505                 510         


Ile Gly Lys Ser Lys Asp Ile Asn Pro Glu Ser Pro Val Ala Leu Leu 
        515                 520                 525             


Ser Met Asn Glu Ile Pro Ala Leu Leu Tyr Glu Ile Leu Val Lys Lys 
    530                 535                 540                 


Ala Ser Pro Glu Glu Val Glu Ala Lys Ile Arg Gln Lys Leu Thr Ala 
545                 550                 555                 560 


Val Phe Glu Arg Ile Arg Asp Tyr Asp Pro Lys Val Pro Leu Pro Ala 
                565                 570                 575     


Ser Gln Val Ser Lys Arg Leu Arg Asn Asn Thr Asp Thr Leu Ser Tyr 
            580                 585                 590         


Asn Lys Glu Lys Leu Val Glu Leu Ala Asn Lys Glu Val Glu Gln Thr 
        595                 600                 605             


Glu Arg Lys Leu Ala Leu Ile Thr Lys Asn Arg Arg Glu Cys Arg Glu 
    610                 615                 620                 


Lys Val Lys Gly Lys Phe Lys Arg Gln Lys Val Phe Lys Asn Ala Glu 
625                 630                 635                 640 


Leu Gly Thr Glu Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met 
                645                 650                 655     


Pro Glu Glu Gln Lys Lys Asn Trp Lys Gly Tyr Gln His Ser Gln Leu 
            660                 665                 670         


Gln Gln Ser Leu Ala Phe Phe Glu Ser Arg Pro Gly Glu Ala Arg Ser 
        675                 680                 685             


Leu Leu Gln Ala Gly Trp Asp Phe Ser Asp Gly Ser Ser Phe Trp Asn 
    690                 695                 700                 


Gly Trp Val Met Asn Ser Phe Ala Arg Asp Asn Thr Phe Asp Gly Phe 
705                 710                 715                 720 


Tyr Glu Ser Tyr Leu Asn Gly Arg Met Lys Tyr Phe Leu Arg Leu Ala 
                725                 730                 735     


Asp Asn Ile Ala Gln Gln Ser Ser Thr Asn Lys Leu Ile Ser Asn Phe 
            740                 745                 750         


Ile Lys Gln Gln Met Pro Lys Gly Leu Phe Asp Arg Arg Leu Tyr Met 
        755                 760                 765             


Leu Glu Asp Leu Ala Thr Glu Lys Asn Lys Ile Leu Ser Lys Pro Leu 
    770                 775                 780                 


Ile Phe Pro Arg Gly Ile Phe Asp Asp Lys Pro Thr Phe Lys Lys Gly 
785                 790                 795                 800 


Val Gln Val Ser Glu Glu Pro Glu Ala Phe Ala Asp Trp Tyr Ser Tyr 
                805                 810                 815     


Gly Tyr Asp Val Lys His Lys Phe Gln Glu Phe Tyr Ala Trp Asp Arg 
            820                 825                 830         


Asp Tyr Glu Glu Leu Leu Arg Glu Glu Leu Glu Lys Asp Thr Ala Phe 
        835                 840                 845             


Thr Lys Asn Ser Ile His Tyr Ser Arg Glu Ser Gln Ile Glu Leu Leu 
    850                 855                 860                 


Ala Lys Lys Gln Asp Leu Lys Val Lys Lys Val Arg Ile Gln Asp Leu 
865                 870                 875                 880 


Tyr Leu Lys Leu Met Ala Glu Phe Leu Phe Glu Asn Val Phe Gly His 
                885                 890                 895     


Glu Leu Ala Leu Pro Leu Asp Gln Phe Tyr Leu Thr Gln Glu Glu Arg 
            900                 905                 910         


Leu Lys Gln Glu Gln Glu Ala Ile Val Gln Ser Gln Arg Pro Lys Gly 
        915                 920                 925             


Asp Asp Ser Pro Asn Ile Val Lys Glu Asn Phe Ile Trp Ser Lys Thr 
    930                 935                 940                 


Ile Pro Phe Lys Ser Gly Arg Val Phe Glu Pro Asn Val Lys Leu Lys 
945                 950                 955                 960 


Asp Ile Gly Lys Phe Arg Asn Leu Leu Thr Asp Glu Lys Val Asp Ile 
                965                 970                 975     


Leu Leu Ser Tyr Asn Asn Thr Glu Ile Gly Lys Gln Val Ile Glu Asn 
            980                 985                 990         


Glu Leu Ile Ile Gly Ala Gly Ser  Tyr Glu Phe Ile Arg  Arg Glu Gln 
        995                 1000                 1005             


Leu Phe  Lys Glu Ile Gln Gln  Met Lys Arg Leu Ser  Leu Arg Ser 
    1010                 1015                 1020             


Val Arg  Gly Met Gly Val Pro  Ile Arg Leu Asn Leu  Lys 
    1025                 1030                 1035     


<210> 29
<211> 1161
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 29
Met Glu Asn Gln Thr Gln Lys Gly Lys Gly Ile Tyr Tyr Tyr Tyr Thr 
1               5                   10                  15      


Lys Asn Glu Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asn 
            20                  25                  30          


Asn Asn Ile Glu Gln Ile Ile Glu Glu Phe Arg Ile Arg Leu Ser Leu 
        35                  40                  45              


Lys Asp Glu Lys Asn Ile Lys Glu Ile Ile Asn Asn Tyr Phe Thr Asp 
    50                  55                  60                  


Lys Lys Ser Tyr Thr Asp Trp Glu Arg Gly Ile Asn Ile Leu Lys Glu 
65                  70                  75                  80  


Tyr Leu Pro Val Ile Asp Tyr Leu Asp Leu Ala Ile Thr Asp Lys Glu 
                85                  90                  95      


Phe Glu Lys Ile Asp Leu Lys Gln Lys Glu Thr Ala Lys Arg Lys Tyr 
            100                 105                 110         


Phe Arg Thr Asn Phe Ser Leu Leu Ile Asp Thr Ile Ile Asp Leu Arg 
        115                 120                 125             


Asn Phe Tyr Thr His Tyr Phe His Lys Pro Ile Ser Ile Asn Pro Asp 
    130                 135                 140                 


Val Ala Lys Phe Leu Asp Lys Asn Leu Leu Asn Val Cys Leu Asp Ile 
145                 150                 155                 160 


Lys Lys Gln Lys Met Lys Thr Asp Lys Thr Lys Gln Ala Leu Lys Asp 
                165                 170                 175     


Gly Leu Asp Lys Glu Leu Lys Lys Leu Ile Glu Leu Lys Lys Ala Glu 
            180                 185                 190         


Leu Lys Glu Lys Lys Ile Lys Thr Trp Asn Ile Thr Glu Asn Val Glu 
        195                 200                 205             


Gly Ala Val Tyr Asn Asp Ala Phe Asn His Met Val Tyr Lys Asn Asn 
    210                 215                 220                 


Ala Gly Val Thr Ile Leu Lys Asp Tyr His Lys Ser Ile Leu Pro Asp 
225                 230                 235                 240 


Asp Lys Ile Asp Ser Glu Leu Lys Leu Asn Phe Ser Ile Ser Gly Leu 
                245                 250                 255     


Val Phe Leu Leu Ser Met Phe Leu Ser Lys Lys Glu Ile Glu Gln Phe 
            260                 265                 270         


Lys Ser Asn Leu Glu Gly Phe Lys Gly Lys Val Ile Gly Glu Asn Gly 
        275                 280                 285             


Glu Tyr Glu Ile Ser Lys Phe Asn Asn Ser Leu Lys Tyr Met Ala Thr 
    290                 295                 300                 


His Trp Ile Phe Ser Tyr Leu Thr Phe Lys Gly Leu Lys Gln Arg Val 
305                 310                 315                 320 


Lys Asn Thr Phe Asp Lys Glu Thr Leu Leu Met Gln Met Ile Asp Glu 
                325                 330                 335     


Leu Asn Lys Val Pro His Glu Val Tyr Gln Thr Leu Ser Lys Glu Gln 
            340                 345                 350         


Gln Asn Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Gln Asp Asn Glu 
        355                 360                 365             


Glu Asn Lys Lys Ser Met Glu Asn Ser Ile Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Asp Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Asn Phe Pro Thr Leu Lys Phe Phe Val Thr Ala Gly 
                405                 410                 415     


Asn Phe Val His Asp Lys Arg Glu Lys Gln Ile Gln Gly Ser Met Leu 
            420                 425                 430         


Thr Ser Asp Arg Met Ile Lys Glu Lys Ile Asn Val Phe Gly Lys Leu 
        435                 440                 445             


Thr Glu Ile Ala Lys Tyr Lys Ser Asp Tyr Phe Ser Asn Glu Asn Thr 
    450                 455                 460                 


Leu Glu Thr Ser Glu Trp Glu Leu Phe Pro Asn Pro Ser Tyr Leu Leu 
465                 470                 475                 480 


Ile Gln Asn Asn Ile Pro Val His Ile Asp Leu Ile His Asn Thr Glu 
                485                 490                 495     


Glu Ala Lys Gln Cys Gln Ile Ala Ile Asp Arg Ile Lys Cys Thr Thr 
            500                 505                 510         


Asn Pro Ala Lys Lys Arg Asn Thr Arg Lys Ser Lys Glu Glu Ile Ile 
        515                 520                 525             


Lys Ile Ile Tyr Gln Lys Asn Lys Asn Ile Lys Tyr Gly Asp Pro Thr 
    530                 535                 540                 


Ala Leu Leu Ser Ser Asn Glu Leu Pro Ala Leu Ile Tyr Glu Leu Leu 
545                 550                 555                 560 


Val Asn Lys Lys Ser Gly Lys Glu Leu Glu Asn Ile Ile Val Glu Lys 
                565                 570                 575     


Ile Val Asn Gln Tyr Lys Thr Ile Ala Gly Phe Glu Lys Gly Gln Asn 
            580                 585                 590         


Leu Ser Asn Ser Leu Ile Thr Lys Lys Leu Lys Lys Ser Glu Pro Asn 
        595                 600                 605             


Glu Asp Lys Ile Asn Ala Glu Lys Ile Ile Leu Ala Ile Asn Arg Glu 
    610                 615                 620                 


Leu Glu Ile Thr Glu Asn Lys Leu Asn Ile Ile Lys Asn Asn Arg Ala 
625                 630                 635                 640 


Glu Phe Arg Thr Gly Ala Lys Arg Lys His Ile Phe Tyr Ser Lys Glu 
                645                 650                 655     


Leu Gly Gln Glu Ala Thr Trp Ile Ala Tyr Asp Leu Lys Arg Phe Met 
            660                 665                 670         


Pro Glu Ala Ser Arg Lys Glu Trp Lys Gly Phe His His Ser Glu Leu 
        675                 680                 685             


Gln Lys Phe Leu Ala Phe Tyr Asp Arg Asn Lys Asn Asp Ala Lys Ala 
    690                 695                 700                 


Leu Leu Asn Met Phe Trp Asn Phe Asp Asn Asp Gln Leu Ile Gly Asn 
705                 710                 715                 720 


Asp Leu Asn Ser Ala Phe Arg Glu Phe His Phe Asp Lys Phe Tyr Glu 
                725                 730                 735     


Lys Tyr Leu Ile Lys Arg Asp Glu Ile Leu Glu Gly Phe Lys Ser Phe 
            740                 745                 750         


Ile Ser Asn Phe Lys Asp Glu Pro Lys Leu Leu Lys Lys Gly Ile Lys 
        755                 760                 765             


Asp Ile Tyr Arg Val Phe Asp Lys Arg Tyr Tyr Ile Ile Lys Ser Thr 
    770                 775                 780                 


Asn Ala Gln Lys Glu Gln Leu Leu Ser Lys Pro Ile Cys Leu Pro Arg 
785                 790                 795                 800 


Gly Ile Phe Asp Asn Lys Pro Thr Tyr Ile Glu Gly Val Lys Val Glu 
                805                 810                 815     


Ser Asn Ser Ala Leu Phe Ala Asp Trp Tyr Gln Tyr Thr Tyr Ser Asp 
            820                 825                 830         


Lys His Glu Phe Gln Ser Phe Tyr Asp Met Pro Arg Asp Tyr Lys Glu 
        835                 840                 845             


Gln Phe Glu Lys Phe Glu Leu Asn Asn Ile Lys Ser Ile Gln Asn Lys 
    850                 855                 860                 


Lys Asn Leu Asn Lys Ser Asp Lys Phe Ile Tyr Phe Arg Tyr Lys Gln 
865                 870                 875                 880 


Asp Leu Lys Ile Lys Gln Ile Lys Ser Gln Asp Leu Phe Ile Lys Leu 
                885                 890                 895     


Met Val Asp Glu Leu Phe Asn Val Val Phe Lys Asn Asn Ile Glu Leu 
            900                 905                 910         


Asn Leu Lys Lys Leu Tyr Gln Thr Ser Asp Glu Arg Phe Lys Asn Gln 
        915                 920                 925             


Leu Ile Ala Asp Val Gln Lys Asn Arg Glu Lys Gly Asp Thr Ser Asp 
    930                 935                 940                 


Asn Lys Met Asn Glu Asn Phe Ile Trp Asn Met Thr Ile Pro Leu Ser 
945                 950                 955                 960 


Leu Cys Asn Gly Gln Ile Glu Glu Pro Lys Val Lys Leu Lys Asp Ile 
                965                 970                 975     


Gly Lys Phe Arg Lys Leu Glu Thr Asp Asp Lys Val Ile Gln Leu Leu 
            980                 985                 990         


Glu Tyr Asp Lys Ser Lys Val Trp  Lys Lys Leu Glu Ile  Glu Asp Glu 
        995                 1000                 1005             


Leu Glu  Asn Met Pro Asn Ser  Tyr Glu Arg Ile Arg  Arg Glu Lys 
    1010                 1015                 1020             


Leu Leu  Lys Gly Ile Gln Glu  Phe Glu His Phe Leu  Leu Glu Lys 
    1025                 1030                 1035             


Glu Lys  Phe Asp Gly Ile Asn  His Pro Lys His Phe  Glu Gln Asp 
    1040                 1045                 1050             


Leu Asn  Pro Asn Phe Lys Thr  Tyr Val Ile Asn Gly  Val Leu Arg 
    1055                 1060                 1065             


Lys Asn  Ser Lys Leu Asn Tyr  Thr Glu Ile Asp Lys  Leu Leu Asp 
    1070                 1075                 1080             


Leu Glu  His Ile Ser Ile Lys  Asp Ile Glu Thr Ser  Ala Lys Glu 
    1085                 1090                 1095             


Ile His  Leu Ala Tyr Phe Leu  Ile His Val Arg Asn  Lys Phe Gly 
    1100                 1105                 1110             


His Asn  Gln Leu Pro Lys Leu  Glu Ala Phe Glu Leu  Met Lys Lys 
    1115                 1120                 1125             


Tyr Tyr  Lys Lys Asn Asn Glu  Glu Thr Tyr Ala Glu  Tyr Phe His 
    1130                 1135                 1140             


Lys Val  Ser Ser Gln Ile Val  Asn Glu Phe Lys Asn  Ser Leu Glu 
    1145                 1150                 1155             


Lys His  Ser 
    1160     


<210> 30
<211> 848
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"


<220>
<221> MOD_RES
<222> (821)..(822)
<223> Any amino acid

<400> 30
Met Glu Lys Thr Gln Thr Gly Leu Gly Ile Tyr Tyr Asp His Thr Lys 
1               5                   10                  15      


Leu Gln Asp Lys Tyr Phe Phe Gly Gly Phe Phe Asn Leu Ala Gln Asn 
            20                  25                  30          


Asn Ile Asp Asn Val Ile Lys Thr Phe Ile Leu Lys Phe Phe Pro Glu 
        35                  40                  45              


Arg Lys Asp Lys Asp Val Asn Ala Ala Gln Phe Leu Asp Ile Cys Phe 
    50                  55                  60                  


Lys Asp Asn Asp Ala Asp Ser Asp Phe Leu Lys Lys Thr Lys Phe Leu 
65                  70                  75                  80  


Arg Met His Phe Pro Val Ile Gly Phe Leu Ala Ser Asn Asn Asp Lys 
                85                  90                  95      


Ala Gly Phe Lys Arg Lys Phe Ser Leu Leu Leu Lys Ala Ile Ser Glu 
            100                 105                 110         


Leu Arg Asn Phe Tyr Thr His Tyr Tyr His Gln Pro Ile Glu Phe Pro 
        115                 120                 125             


Ser Glu Leu Phe Glu Leu Leu Asp Asp Ile Phe Val Glu Thr Thr Ser 
    130                 135                 140                 


Glu Ile Lys Lys Leu Lys Lys Lys Asp Asp Lys Thr Gln Gln Leu Leu 
145                 150                 155                 160 


Asn Lys Asn Leu Ser Glu Glu Tyr Asp Ile Arg Tyr Gln Gln Gln Ile 
                165                 170                 175     


Glu Arg Leu Lys Glu Leu Asn Ala Gln Gly Lys Lys Ile Pro Leu Asn 
            180                 185                 190         


Asp Glu Thr Ala Ile Arg Asn Gly Val Phe Asn Ala Ala Phe Asn His 
        195                 200                 205             


Leu Ile Tyr Lys Asp Gly Gly Asp Leu Lys Pro Ser Arg Val Tyr Gln 
    210                 215                 220                 


Ser Ser Tyr Ser Glu Pro Asp Pro Ala Glu Asn Gly Thr Ser Leu Ser 
225                 230                 235                 240 


Gln Ser Ser Ile Leu Phe Leu Leu Ser Met Phe Leu Glu Arg Lys Glu 
                245                 250                 255     


Thr Glu Asp Leu Lys Ser Arg Val Lys Gly Phe Lys Ala Lys Phe Ile 
            260                 265                 270         


Lys Asn Gly Glu Glu Lys Ile Ser Asn Leu Lys Leu Thr Ala Thr His 
        275                 280                 285             


Trp Val Phe Ser Tyr Leu Cys Phe Lys Gly Ile Lys Gln Lys Leu Ser 
    290                 295                 300                 


Thr Glu Phe His Glu Glu Thr Leu Leu Ile Gln Ile Ile Asp Glu Leu 
305                 310                 315                 320 


Ser Lys Val Pro Asp Glu Val Tyr Ser Ala Phe Gly Ala Lys Thr Lys 
                325                 330                 335     


Gln Lys Phe Val Glu Asp Ile Asn Glu Tyr Met Lys Glu Gly Asn Ala 
            340                 345                 350         


Asp Leu Ser Leu Glu Asp Ser Lys Val Ile His Pro Val Ile Arg Lys 
        355                 360                 365             


Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu 
    370                 375                 380                 


Tyr Leu Ser Ser Thr Ser Leu Lys Phe Gln Val His Val Gly Asn Tyr 
385                 390                 395                 400 


Val His Asp Arg Arg Ile Lys Asn Ile Asn Gly Thr Asp Phe Gln Thr 
                405                 410                 415     


Glu Arg Val Val Lys Asp Ser Ile Lys Val Phe Gly Arg Leu Ser Lys 
            420                 425                 430         


Ile Ser Asn Leu Lys Ala Asp Tyr Ile Lys Glu Gln Leu Ser Leu Pro 
        435                 440                 445             


Asn Asp Ser Asn Gly Trp Glu Ile Phe Pro Asn Pro Ser Tyr Val Phe 
    450                 455                 460                 


Ile Asp Asn Asn Val Pro Ile His Ile Gln Thr Asp Glu Ala Thr Lys 
465                 470                 475                 480 


Asn Gly Ile Lys Leu Phe Lys Asp Thr Arg Arg Lys Glu Gln Pro Glu 
                485                 490                 495     


Glu Leu Gln Lys Arg Lys Gly Lys Leu Ser Lys His Asn Ile Val Glu 
            500                 505                 510         


Ile Ile Phe Lys Glu Thr Lys Gly Lys Asp Lys Pro Arg Val Asp Glu 
        515                 520                 525             


Pro Leu Ala Leu Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu Tyr Gln 
    530                 535                 540                 


Ile Leu Glu Lys Gly Ala Thr Pro Glu Asp Ile Glu Leu Ile Ile Lys 
545                 550                 555                 560 


Asn Lys Leu Ala Glu Arg Phe Glu Lys Ile Lys Asn Tyr Asp Pro Glu 
                565                 570                 575     


Thr Pro Ala Pro Ala Ser Gln Ile Ser Lys Arg Leu Arg Asn Asn Thr 
            580                 585                 590         


Thr Ala Lys Gly Gln Glu Thr Leu Asn Ala Glu Lys Leu Ser Ile Leu 
        595                 600                 605             


Ile Glu Arg Glu Ile Glu Asp Thr Glu Thr Lys Leu Asp Ala Ile Glu 
    610                 615                 620                 


Glu Lys Arg Arg Lys Ala Lys Lys Glu Tyr Arg Arg Asn Ser Pro Gln 
625                 630                 635                 640 


Lys Ser Ile Phe Ser Asn Ser Glu Leu Gly Arg Ile Ala Ala Trp Leu 
                645                 650                 655     


Ala Asp Asp Ile Lys Arg Phe Met Pro Ala Glu Leu Arg Lys Asn Trp 
            660                 665                 670         


Lys Gly Tyr Gln His Ser Gln Leu Gln Gln Ser Leu Ala Tyr Phe Glu 
        675                 680                 685             


Lys Arg Pro Gln Glu Ala Phe Leu Leu Leu Lys Glu Gly Trp Asp Thr 
    690                 695                 700                 


Ser Asp Gly Ser Ser Tyr Trp Asn Ile Trp Val Ile Asn Ser Phe Ser 
705                 710                 715                 720 


Glu Thr Glu Asp Phe Glu Lys Phe Tyr Glu Asn Tyr Leu Arg Lys Arg 
                725                 730                 735     


Ala Lys Tyr Phe Ser Glu Leu Ala Gly Asn Ile Lys Gln His Thr His 
            740                 745                 750         


Asn Ala Lys Phe Leu Arg Lys Phe Ile Lys Gln Gln Met Pro Ala Asp 
        755                 760                 765             


Leu Phe Pro Lys Arg His Tyr Ile Leu Lys Asp Leu Glu Thr Glu Lys 
    770                 775                 780                 


Asn Lys Val Leu Ser Lys Pro Leu Val Phe Ser Arg Gly Leu Phe Asp 
785                 790                 795                 800 


Ser Asn Pro Thr Phe Ile Lys Gly Val Lys Val Thr Glu Asn Pro Glu 
                805                 810                 815     


Leu Phe Ala Glu Xaa Xaa Asn Gly Ile Ala Thr Gly Thr Lys Arg Asn 
            820                 825                 830         


Ile Pro Ser Ser Ile Ser Met Ala Gly Lys Glu Thr Ile Met Ser Phe 
        835                 840                 845             


<210> 31
<211> 1241
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"


<220>
<221> MOD_RES
<222> (644)..(727)
<223> Any amino acid

<400> 31
Met Glu Gln Asn Lys Leu Gly Lys Gly Ile Asp Tyr Asn Pro Phe Lys 
1               5                   10                  15      


Thr Val Asp Lys His Tyr Phe Gly Gly Phe Phe Asn Leu Ala Asp Asn 
            20                  25                  30          


Asn Ile Gln Glu Val Phe Asp Glu Ile Asn Ile Arg Tyr Lys Asn Gly 
        35                  40                  45              


Asn Leu Lys Pro Lys Val Ala Ile Glu Arg Tyr Thr Thr Glu Asn Thr 
    50                  55                  60                  


Ser Leu Val Glu Tyr Glu Lys Phe Val Ala Ile Leu Thr Glu Tyr Phe 
65                  70                  75                  80  


Pro Ile Val Lys Glu Ile Asp Gln Lys Asn Lys Lys Asp Ser Asn Asp 
                85                  90                  95      


Lys Val Ile Glu Lys Thr Arg Ile Glu Arg Ile Thr Asp Phe Arg Asp 
            100                 105                 110         


Ala Phe Ile Leu Phe Ile Glu Thr Ile Glu Lys Leu Arg Ser Tyr Tyr 
        115                 120                 125             


Thr His Tyr Gln His Asp Asp Ile Thr Ile Asp Asn Gln Leu Phe Ile 
    130                 135                 140                 


His Leu Asp Lys Ile Leu Leu Asn Thr Val Leu Glu Thr Lys Lys Lys 
145                 150                 155                 160 


Tyr Leu Lys Thr Asp Lys Thr Lys Glu Leu Leu Lys Asn Ser Leu Gln 
                165                 170                 175     


Ala Glu Leu Lys Glu Leu Tyr His Leu Lys Ile Asn Gln Leu Glu Gln 
            180                 185                 190         


Lys Lys Asn Glu Val Asp Ala Leu Ile Lys Glu Gln Lys Ser Lys Gly 
        195                 200                 205             


Lys Lys Thr Asp Lys Pro Phe Lys Tyr Ser Lys Asp Arg Asp Gln Ile 
    210                 215                 220                 


Ile Asn Ser Ile Tyr Asn Asp Ala Ile Arg Pro Phe Leu Tyr Glu Asn 
225                 230                 235                 240 


Ala Asn Lys Val Glu Leu Ser Asp Lys Lys Lys Thr Ala Phe Asn Glu 
                245                 250                 255     


Lys Asp Ala Ser Ala Ser Glu Arg Asp Phe Asn Leu Pro Ile Ser Ser 
            260                 265                 270         


Ser Gly Ile Ile Phe Leu Leu Ser Cys Phe Leu Asn Arg Lys Glu Ile 
        275                 280                 285             


Glu Asp Leu Lys Ala Asn Ile Lys Gly Tyr Lys Gly Lys Val Ile Lys 
    290                 295                 300                 


Gly Glu Thr Phe Asp Leu Glu Lys Asn Ser Ile Arg Phe Met Ala Thr 
305                 310                 315                 320 


His Arg Ile Tyr Ser Val Met Cys Tyr Lys Gly Leu Lys Asn Lys Ile 
                325                 330                 335     


Arg Thr Ser Glu Ser Ala Thr Lys Glu Thr Leu Leu Met Gln Met Ile 
            340                 345                 350         


Asp Glu Leu Ser Lys Ile Pro Asp Ile Val Tyr Lys Asn Ile Ser Thr 
        355                 360                 365             


Asp Leu Gln Asn Thr Phe Thr Glu Asp Trp Asn Glu Tyr Tyr Lys Asp 
    370                 375                 380                 


Asn Ile Glu Asn Asn Glu Asn Leu Glu Asn Ser Lys Val Ile His Pro 
385                 390                 395                 400 


Val Ile Arg Lys Arg Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg 
                405                 410                 415     


Phe Leu Asp Glu Phe Val Asp Phe Pro Ser Leu Arg Phe Gln Val His 
            420                 425                 430         


Leu Gly Asn Tyr Ile Lys His Ser Met Pro Lys Asn Ile Gly Ser Val 
        435                 440                 445             


Thr Thr Thr Arg Glu Ile Lys Asn Lys Ile Phe Val Phe Gly Lys Leu 
    450                 455                 460                 


Asn Glu Ile Asn Gln Ser Lys Asn Asp Phe Phe Asn Lys Asn Lys Glu 
465                 470                 475                 480 


Glu Glu Gln Glu Thr Asn Trp Glu Ile Phe Pro Asn Pro Asn Tyr His 
                485                 490                 495     


Phe Pro Met Glu Asn Ser Asp Glu Leu Lys Asn Ala Asn Lys Ile Gly 
            500                 505                 510         


Ile Tyr Ile Asp Leu Lys Asp Lys Arg Lys Lys Asp Thr Leu Asn Glu 
        515                 520                 525             


Ala Ile Lys Lys Arg Glu Lys Glu Thr Ser Ile Tyr Lys Lys Asp Leu 
    530                 535                 540                 


Val His Gln Ile Ile Asp Lys Asn Leu Asp Met His Ile Gly Gln Pro 
545                 550                 555                 560 


Val Ala Tyr Leu Ser Met Asn Asp Ile His Ala Ile Ile Phe Ser Ile 
                565                 570                 575     


Leu Ser Gln Asn Val Phe Thr Lys Asp Asn Lys Leu Asn Gly Gly Asp 
            580                 585                 590         


Ile Glu Lys Lys Ile Lys Asp Gln Ile Asn Asn Gln Ile Thr Glu Ile 
        595                 600                 605             


Thr Glu Lys Asp Ala Ser Ile Lys Ile Leu Lys Asn His Ser Asp Asn 
    610                 615                 620                 


Asn Ser Asn Tyr Pro Asn Thr His Lys Leu Tyr Asp Asp Ile Ser Asn 
625                 630                 635                 640 


Glu Ile Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Glu Ile Glu Val Leu Asp Lys Leu 
                725                 730                 735     


Met Gln Lys His Glu Lys Arg Val Lys Glu Tyr Ile Asn Thr Gln Glu 
            740                 745                 750         


Asp Lys Lys Tyr Lys Pro Ala Arg Lys His Ile Leu Tyr Asn Ser Glu 
        755                 760                 765             


Lys Gly Glu Ile Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Phe 
    770                 775                 780                 


Pro Lys Glu Phe Lys Glu Asn Trp Lys Gly His Tyr His Ser Glu Phe 
785                 790                 795                 800 


Gln Arg Asn Leu Ala Tyr Tyr Glu Thr Asn Lys Lys Glu Val Lys Thr 
                805                 810                 815     


Ile Leu Asn Asp Leu Asp Tyr Arg Lys Glu Ile Pro Phe Ile Asp Phe 
            820                 825                 830         


Ser Lys Asn Thr Leu Ala Asp Phe Tyr Phe Glu Tyr Leu Lys Lys Arg 
        835                 840                 845             


Lys Ile Tyr His Lys Asn Leu Trp Val Glu Val Asn Lys Leu Ile Lys 
    850                 855                 860                 


Gly Glu Asn Ile Asn Lys Glu Lys Leu Phe Asp Asn Cys Phe Arg Ile 
865                 870                 875                 880 


Tyr Lys Arg Lys Asn Tyr Val Ser Asn Val Ile Asp Glu Lys Val Asn 
                885                 890                 895     


Thr Ile Leu Ser Asn Pro Ile Phe Ile Glu Arg Gly Phe Ile Asp Glu 
            900                 905                 910         


Lys Pro Thr Ile Ile Pro Lys Met Pro Leu Glu Gly Asn Glu Glu His 
        915                 920                 925             


Phe Ala Ala Trp Phe Val Ala Phe Lys Ser Phe Lys Asn Asn Glu Phe 
    930                 935                 940                 


Gln Asn Phe Tyr Asp Thr Asn Lys Tyr Pro Leu Glu Thr Lys Asp Lys 
945                 950                 955                 960 


Thr Asn Ser Glu Leu Lys Lys Ile Gln Thr Lys Thr Tyr Asn Gln Lys 
                965                 970                 975     


Lys Asn Asp Trp Ala Thr Trp Leu Ile Val Gln Tyr Ile Phe Lys Asp 
            980                 985                 990         


Ile Phe Ser Thr Asp Leu Gln Asn  Val Lys Leu Ser Glu  Leu Phe Gln 
        995                 1000                 1005             


Thr Arg  Glu Gln Arg Ile Gln  Asn Gln Val Lys Ala  Leu Asp Gly 
    1010                 1015                 1020             


Glu Arg  Asn Gln Asn Phe Ile  Trp Asn Arg Thr Ile  Asp Leu Gln 
    1025                 1030                 1035             


Leu Asn  Glu Lys Ile Lys Ile  Pro Asn Val Lys Leu  Lys Asp Ile 
    1040                 1045                 1050             


Gly Asn  Phe Arg Lys Tyr Val  Asn Asp Ser Arg Val  Glu Ala Phe 
    1055                 1060                 1065             


Leu Arg  Tyr Asn Asp Ile Thr  Gln Trp Met Ala Tyr  Leu Pro Ser 
    1070                 1075                 1080             


Asn Trp  Gln Lys Glu Asp Glu  Ser Lys Pro Lys Pro  Val Asn Val 
    1085                 1090                 1095             


Ile Gln  Leu Gln Leu Asp Asp  Tyr Glu Lys Ile Arg  Arg Glu Glu 
    1100                 1105                 1110             


Leu Leu  Lys Glu Val Gln Lys  Leu Glu Lys Thr Ile  Tyr Asn Asn 
    1115                 1120                 1125             


Thr Asn  Val Lys Thr Val Leu  Leu Gln Asp Gly Asn  Pro Asn Phe 
    1130                 1135                 1140             


Lys Asn  Tyr Val Leu Asn Gly  Leu Leu Glu Glu Ile  Lys Gly Ile 
    1145                 1150                 1155             


Asn Ile  Ser Ala Phe Thr Val  Leu His Glu Lys Thr  Asn Phe Asp 
    1160                 1165                 1170             


Lys Ile  Asp Phe Asn Val Leu  Glu Asn Cys Ser Glu  Ile Glu Gln 
    1175                 1180                 1185             


Ser Ala  Thr Leu Ile Ile Leu  Ile Arg Asn Lys Phe  Ala His Asn 
    1190                 1195                 1200             


Gln Leu  Pro Ser Ser Asp Cys  Tyr Gln Phe Cys Ser  Lys Ile Leu 
    1205                 1210                 1215             


Thr Arg  Asp Thr Glu Gln Thr  Tyr Ala Asn Tyr Tyr  Leu Lys Leu 
    1220                 1225                 1230             


Phe Met  Ile Leu Lys Asp Lys  Leu 
    1235                 1240     


<210> 32
<211> 1147
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 32
Met Glu Glu Thr Thr Thr Met Gly Lys Gly Val Ala Tyr Asp His Thr 
1               5                   10                  15      


Leu Phe Lys Asp Lys His Tyr Phe Ala Gly Tyr Leu Asn Leu Ala Val 
            20                  25                  30          


Asn Asn Ile Glu Asn Val Phe Lys Thr Val Tyr Lys Asn Arg Phe Asp 
        35                  40                  45              


Ile Lys Gln His Asn Leu Tyr Lys Ile Leu Asp Ser Leu Asp Gly Gln 
    50                  55                  60                  


Ile Ser Glu Pro Asp Tyr Ile Glu Arg Val Ser Phe Leu Lys Gln Tyr 
65                  70                  75                  80  


Phe Pro Val Leu His Tyr Leu Asp Leu His Pro Asp Asn Lys Arg Phe 
                85                  90                  95      


Thr Lys Glu Glu Asp Lys Val Lys Ala Arg Arg Arg Tyr Leu Ile Asn 
            100                 105                 110         


Asn Leu Arg Leu Leu Ile Glu Thr Leu Ser Lys Leu Arg Asp Phe Tyr 
        115                 120                 125             


Thr His Tyr Tyr His Lys Pro Leu Ser Ile Glu Gln Asn Thr Phe Ser 
    130                 135                 140                 


Leu Ile Asp Asn Ile Phe Leu Asn Val Val Ile Asp Val Lys Arg Gln 
145                 150                 155                 160 


Lys Lys Lys Asn Asp His Thr Arg Gln Leu Leu Lys Asp Ser Leu Lys 
                165                 170                 175     


Glu Glu Met Asp Ile Leu Tyr Gln Lys Thr Lys Ala Ser Leu Lys Glu 
            180                 185                 190         


Lys Gln Lys Glu Asn Thr Arg Ile Lys Leu Asp Ser Glu Thr Ile Asn 
        195                 200                 205             


Asn Thr Ile Phe Asn Asn Ser Phe Ser His Leu Ile Tyr Arg Arg Lys 
    210                 215                 220                 


Lys Ala Asp Asn Asp Ile Leu Ser Ala Ser Cys Lys Ser Glu Tyr Lys 
225                 230                 235                 240 


Gly Glu Pro Thr Glu Asn Gly Ile Asn Val Ser Val Asp Gly Leu Leu 
                245                 250                 255     


Phe Phe Leu Gly Ile Phe Leu Ser Arg Lys Glu Ser Asn Asp Leu Arg 
            260                 265                 270         


Gly Arg Ile Lys Gly Phe Lys Gly Thr Val Ile Lys Asp Leu Pro Asp 
        275                 280                 285             


Phe Pro Asn Glu Lys Asn Asn Ser Leu Lys Phe Met Ala Thr His Trp 
    290                 295                 300                 


Val Phe Thr Tyr Leu Asn Ile Lys Pro Ile Lys Gln Lys Leu Asn Thr 
305                 310                 315                 320 


Asn Phe Ser Arg Glu Thr Leu Leu Leu Gln Ile Val Asp Glu Leu Thr 
                325                 330                 335     


Lys Ile Pro Asn Glu Ile Tyr Arg Asn Leu Cys Phe Lys Lys Gln Gln 
            340                 345                 350         


Glu Phe Val Glu Asp Ile Asn Glu Tyr Ile Lys Glu Gly Asp Asp Ile 
        355                 360                 365             


Asp Thr Leu Asn Ser Ser Thr Val Ile His Pro Val Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asn Lys Phe Asn Tyr Phe Val Leu Arg Tyr Leu Asp Glu Phe 
385                 390                 395                 400 


Val Ser Phe Asn Ser Leu Arg Phe Gln Ile Tyr Leu Gly Asn Tyr Val 
                405                 410                 415     


His His Ile Gln Arg Lys Lys Leu Ser Gly Thr Glu Tyr Glu Thr Glu 
            420                 425                 430         


Arg Val Ile Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Glu Val 
        435                 440                 445             


Ser Asn Ile Lys Gly Asp Tyr Phe Ile Gln Asn Asn Pro Asp Asn Glu 
    450                 455                 460                 


Ala Leu Gly Trp Glu Ile Tyr Pro Asn Pro Ser Tyr Asn Phe Thr Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Ile Tyr Phe Asp Ile Asn Asp Gln Asp Lys Glu Lys 
                485                 490                 495     


Ile Asn Glu Tyr Lys Ser Ile Arg Asn Phe Ser Glu Lys Arg Ile Leu 
            500                 505                 510         


Arg Lys Lys Asn Lys Lys Asn Lys Gln Glu Ile Phe Asp Leu Ile Asn 
        515                 520                 525             


Asn Thr Leu Thr Thr Arg Val Phe Thr Ala Glu Pro Thr Ala Ile Leu 
    530                 535                 540                 


Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr Thr Ile Leu Cys Glu Asn 
545                 550                 555                 560 


Lys Thr Ala Ser Glu Ile Glu Asn Leu Leu Arg Arg Thr Tyr Leu Lys 
                565                 570                 575     


Arg Leu Asn Thr Ile Lys Asn Tyr Gln Pro Gly Thr Leu Pro Gln Ser 
            580                 585                 590         


Lys Ile Thr Lys Asn Leu Asn Lys Ser Thr Asn Gln Glu Ser Leu Asp 
        595                 600                 605             


Val Ser Lys Leu Ile Lys Ala Met Lys His Glu Ile Ser Ile Ser Asn 
    610                 615                 620                 


Glu Lys Leu Thr Leu Ile Lys Lys Asn Gln Asn Glu Val Lys Asp Thr 
625                 630                 635                 640 


Ser His Arg Arg Lys Tyr Val Phe Asn Ser Lys Glu Leu Gly Ile Glu 
                645                 650                 655     


Ala Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Lys Val 
            660                 665                 670         


Arg Glu Asn Trp Lys Gly Tyr Met His Ser Gln Leu Gln Asn Ser Ile 
        675                 680                 685             


Ala Tyr Tyr Ser Gln Lys Pro Lys Glu Ala Leu Ser Ile Leu Ser Ser 
    690                 695                 700                 


Val Trp Asn Phe Asn Asp Asp Asn Tyr Ile Trp Asn Glu Gly Ile Lys 
705                 710                 715                 720 


Lys Ala Phe Asn Glu Lys Glu Phe Glu Lys Phe Tyr Cys Lys Tyr Leu 
                725                 730                 735     


Ala Ser Arg Asn Lys Thr Leu Glu Lys Leu Lys Glu Asn Leu Asp Asn 
            740                 745                 750         


Leu Glu Tyr Lys Thr Asp Lys Arg Lys Leu Asp Lys Phe Ile Lys Gln 
        755                 760                 765             


Gln Asn Leu Asp Cys Leu Phe His Ile Arg Thr Tyr Thr Ile Asp Ser 
    770                 775                 780                 


Thr Gln Glu Gln Ile Asn Lys Leu Leu Ala Lys Pro Leu Val Phe Pro 
785                 790                 795                 800 


Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe Val Lys Asn Glu Ser Val 
                805                 810                 815     


Thr Glu Lys Pro Glu Leu Phe Ala Asp Trp Tyr Thr Tyr Thr Tyr Lys 
            820                 825                 830         


Glu His Pro Leu Gln Glu Phe Tyr Ser Phe Thr Lys Asp Tyr Glu Cys 
        835                 840                 845             


Asn Phe Lys Lys Glu Lys Leu Thr Val Lys Glu Phe Val Lys Asn Gln 
    850                 855                 860                 


Glu Gln Leu Asn Pro Glu Glu Gln Leu Asn Leu Phe Lys Leu Lys Glu 
865                 870                 875                 880 


Asp Leu Ser Ile Lys Cys Ile Lys Asn Gln Asp Leu Phe Leu Lys Leu 
                885                 890                 895     


Val Val Asp Asn Ile Tyr Asn Lys Ile Phe Glu Tyr Asn Ile Asp Ile 
            900                 905                 910         


Ser Leu Lys Asn Leu Tyr Ile Ser Arg Lys Glu Arg Ile Ala Ile Gly 
        915                 920                 925             


Leu Lys Ala Lys Glu Leu Asn Gln Ile Asn Asp Ser Tyr Ile Trp Gly 
    930                 935                 940                 


Lys Thr Ile Leu Tyr Gln Asp Lys Gln Ile Arg Glu Thr Lys Val Gln 
945                 950                 955                 960 


Leu Lys Asp Ile Asn Lys Ile Lys Arg Phe Leu Glu Glu Asp Lys Val 
                965                 970                 975     


Lys Gln Ile Leu Ser Tyr Asp Ile Asn Lys Gln Trp Glu Ile Glu Glu 
            980                 985                 990         


Leu Lys Tyr Glu Leu Tyr Ile Lys  Pro Asn Ser Tyr Glu  Val Ile Arg 
        995                 1000                 1005             


Arg Glu  Lys Leu Phe Lys Ala  Ile Gln Glu Phe Glu  Ser Tyr Ile 
    1010                 1015                 1020             


Leu Thr  Ile Asn Asn Phe Asp  Gly Ser Asn His Pro  Ser Ile Leu 
    1025                 1030                 1035             


Glu Tyr  Asn Ser Asn Pro Arg  Phe Lys His Tyr Val  Val Asn Gly 
    1040                 1045                 1050             


Leu Leu  Leu Lys Lys Gly Leu  Ala Thr Asn Glu Glu  Ile Glu Trp 
    1055                 1060                 1065             


Leu Leu  Ala Lys Gly Gln Lys  Glu Phe Asn Thr Phe  Asp Lys Ser 
    1070                 1075                 1080             


Ile Val  Glu Lys Pro Glu Ile  Ile Gln Lys Ala Phe  Leu Leu Val 
    1085                 1090                 1095             


Leu Ile  Arg Asn Lys Phe Ala  His Ser Gln Leu Pro  Ile Lys Glu 
    1100                 1105                 1110             


Tyr Tyr  Glu Met Ile Arg Ser  Tyr Thr Lys Asn Ile  Glu Asn Leu 
    1115                 1120                 1125             


Asn Thr  Thr Glu Ile Ile Phe  Gln Phe Thr Thr Asn  Thr Ile Asn 
    1130                 1135                 1140             


Glu Leu  Lys Arg 
    1145         


<210> 33
<211> 1108
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12b sequence"

<400> 33
Met Ala Thr Arg Ser Phe Ile Leu Lys Ile Glu Pro Asn Glu Glu Val 
1               5                   10                  15      


Lys Lys Gly Leu Trp Lys Thr His Glu Val Leu Asn His Gly Ile Ala 
            20                  25                  30          


Tyr Tyr Met Asn Ile Leu Lys Leu Ile Arg Gln Glu Ala Ile Tyr Glu 
        35                  40                  45              


His His Glu Gln Asp Pro Lys Asn Pro Lys Lys Val Ser Lys Ala Glu 
    50                  55                  60                  


Ile Gln Ala Glu Leu Trp Asp Phe Val Leu Lys Met Gln Lys Cys Asn 
65                  70                  75                  80  


Ser Phe Thr His Glu Val Asp Lys Asp Val Val Phe Asn Ile Leu Arg 
                85                  90                  95      


Glu Leu Tyr Glu Glu Leu Val Pro Ser Ser Val Glu Lys Lys Gly Glu 
            100                 105                 110         


Ala Asn Gln Leu Ser Asn Lys Phe Leu Tyr Pro Leu Val Asp Pro Asn 
        115                 120                 125             


Ser Gln Ser Gly Lys Gly Thr Ala Ser Ser Gly Arg Lys Pro Arg Trp 
    130                 135                 140                 


Tyr Asn Leu Lys Ile Ala Gly Asp Pro Ser Trp Glu Glu Glu Lys Lys 
145                 150                 155                 160 


Lys Trp Glu Glu Asp Lys Lys Lys Asp Pro Leu Ala Lys Ile Leu Gly 
                165                 170                 175     


Lys Leu Ala Glu Tyr Gly Leu Ile Pro Leu Phe Ile Pro Phe Thr Asp 
            180                 185                 190         


Ser Asn Glu Pro Ile Val Lys Glu Ile Lys Trp Met Glu Lys Ser Arg 
        195                 200                 205             


Asn Gln Ser Val Arg Arg Leu Asp Lys Asp Met Phe Ile Gln Ala Leu 
    210                 215                 220                 


Glu Arg Phe Leu Ser Trp Glu Ser Trp Asn Leu Lys Val Lys Glu Glu 
225                 230                 235                 240 


Tyr Glu Lys Val Glu Lys Glu His Lys Thr Leu Glu Glu Arg Ile Lys 
                245                 250                 255     


Glu Asp Ile Gln Ala Phe Lys Ser Leu Glu Gln Tyr Glu Lys Glu Arg 
            260                 265                 270         


Gln Glu Gln Leu Leu Arg Asp Thr Leu Asn Thr Asn Glu Tyr Arg Leu 
        275                 280                 285             


Ser Lys Arg Gly Leu Arg Gly Trp Arg Glu Ile Ile Gln Lys Trp Leu 
    290                 295                 300                 


Lys Met Asp Glu Asn Glu Pro Ser Glu Lys Tyr Leu Glu Val Phe Lys 
305                 310                 315                 320 


Asp Tyr Gln Arg Lys His Pro Arg Glu Ala Gly Asp Tyr Ser Val Tyr 
                325                 330                 335     


Glu Phe Leu Ser Lys Lys Glu Asn His Phe Ile Trp Arg Asn His Pro 
            340                 345                 350         


Glu Tyr Pro Tyr Leu Tyr Ala Thr Phe Cys Glu Ile Asp Lys Lys Lys 
        355                 360                 365             


Lys Asp Ala Lys Gln Gln Ala Thr Phe Thr Leu Ala Asp Pro Ile Asn 
    370                 375                 380                 


His Pro Leu Trp Val Arg Phe Glu Glu Arg Ser Gly Ser Asn Leu Asn 
385                 390                 395                 400 


Lys Tyr Arg Ile Leu Thr Glu Gln Leu His Thr Glu Lys Leu Lys Lys 
                405                 410                 415     


Lys Leu Thr Val Gln Leu Asp Arg Leu Ile Tyr Pro Thr Glu Ser Gly 
            420                 425                 430         


Gly Trp Glu Glu Lys Gly Lys Val Asp Ile Val Leu Leu Pro Ser Arg 
        435                 440                 445             


Gln Phe Tyr Asn Gln Ile Phe Leu Asp Ile Glu Glu Lys Gly Lys His 
    450                 455                 460                 


Ala Phe Thr Tyr Lys Asp Glu Ser Ile Lys Phe Pro Leu Lys Gly Thr 
465                 470                 475                 480 


Leu Gly Gly Ala Arg Val Gln Phe Asp Arg Asp His Leu Arg Arg Tyr 
                485                 490                 495     


Pro His Lys Val Glu Ser Gly Asn Val Gly Arg Ile Tyr Phe Asn Met 
            500                 505                 510         


Thr Val Asn Ile Glu Pro Thr Glu Ser Pro Val Ser Lys Ser Leu Lys 
        515                 520                 525             


Ile His Arg Asp Asp Phe Pro Lys Phe Val Asn Phe Lys Pro Lys Glu 
    530                 535                 540                 


Leu Thr Glu Trp Ile Lys Asp Ser Lys Gly Lys Lys Leu Lys Ser Gly 
545                 550                 555                 560 


Ile Glu Ser Leu Glu Ile Gly Leu Arg Val Met Ser Ile Asp Leu Gly 
                565                 570                 575     


Gln Arg Gln Ala Ala Ala Ala Ser Ile Phe Glu Val Val Asp Gln Lys 
            580                 585                 590         


Pro Asp Ile Glu Gly Lys Leu Phe Phe Pro Ile Lys Gly Thr Glu Leu 
        595                 600                 605             


Tyr Ala Val His Arg Ala Ser Phe Asn Ile Lys Leu Pro Gly Glu Thr 
    610                 615                 620                 


Leu Val Lys Ser Arg Glu Val Leu Arg Lys Ala Arg Glu Asp Asn Leu 
625                 630                 635                 640 


Lys Leu Met Asn Gln Lys Leu Asn Phe Leu Arg Asn Val Leu His Phe 
                645                 650                 655     


Gln Gln Phe Glu Asp Ile Thr Glu Arg Glu Lys Arg Val Thr Lys Trp 
            660                 665                 670         


Ile Ser Arg Gln Glu Asn Ser Asp Val Pro Leu Val Tyr Gln Asp Glu 
        675                 680                 685             


Leu Ile Gln Ile Arg Glu Leu Met Tyr Lys Pro Tyr Lys Asp Trp Val 
    690                 695                 700                 


Ala Phe Leu Lys Gln Leu His Lys Arg Leu Glu Val Glu Ile Gly Lys 
705                 710                 715                 720 


Glu Val Lys His Trp Arg Lys Ser Leu Ser Asp Gly Arg Lys Gly Leu 
                725                 730                 735     


Tyr Gly Ile Ser Leu Lys Asn Ile Asp Glu Ile Asp Arg Thr Arg Lys 
            740                 745                 750         


Phe Leu Leu Arg Trp Ser Leu Arg Pro Thr Glu Pro Gly Glu Val Arg 
        755                 760                 765             


Arg Leu Glu Pro Gly Gln Arg Phe Ala Ile Asp Gln Leu Asn His Leu 
    770                 775                 780                 


Asn Ala Leu Lys Glu Asp Arg Leu Lys Lys Met Ala Asn Thr Ile Ile 
785                 790                 795                 800 


Met His Ala Leu Gly Tyr Cys Tyr Asp Val Arg Lys Lys Lys Trp Gln 
                805                 810                 815     


Ala Lys Asn Pro Ala Cys Gln Ile Ile Leu Phe Glu Asp Leu Ser Asn 
            820                 825                 830         


Tyr Asn Pro Tyr Glu Glu Arg Ser Arg Phe Glu Asn Ser Lys Leu Met 
        835                 840                 845             


Lys Trp Ser Arg Arg Glu Ile Pro Arg Gln Val Ala Leu Gln Gly Glu 
    850                 855                 860                 


Ile Tyr Gly Leu Gln Val Gly Glu Val Gly Ala Gln Phe Ser Ser Arg 
865                 870                 875                 880 


Phe His Ala Lys Thr Gly Ser Pro Gly Ile Arg Cys Ser Val Val Thr 
                885                 890                 895     


Lys Glu Lys Leu Gln Asp Asn Arg Phe Phe Lys Asn Leu Gln Arg Glu 
            900                 905                 910         


Gly Arg Leu Thr Leu Asp Lys Ile Ala Val Leu Lys Glu Gly Asp Leu 
        915                 920                 925             


Tyr Pro Asp Lys Gly Gly Glu Lys Phe Ile Ser Leu Ser Lys Asp Arg 
    930                 935                 940                 


Lys Leu Val Thr Thr His Ala Asp Ile Asn Ala Ala Gln Asn Leu Gln 
945                 950                 955                 960 


Lys Arg Phe Trp Thr Arg Thr His Gly Phe Tyr Lys Val Tyr Cys Lys 
                965                 970                 975     


Ala Tyr Gln Val Asp Gly Gln Thr Val Tyr Ile Pro Glu Ser Lys Asp 
            980                 985                 990         


Gln Lys Gln Lys Ile Ile Glu Glu  Phe Gly Glu Gly Tyr  Phe Ile Leu 
        995                 1000                 1005             


Lys Asp  Gly Val Tyr Glu Trp  Gly Asn Ala Gly Lys  Leu Lys Ile 
    1010                 1015                 1020             


Lys Lys  Gly Ser Ser Lys Gln  Ser Ser Ser Glu Leu  Val Asp Ser 
    1025                 1030                 1035             


Asp Ile  Leu Lys Asp Ser Phe  Asp Leu Ala Ser Glu  Leu Lys Gly 
    1040                 1045                 1050             


Glu Lys  Leu Met Leu Tyr Arg  Asp Pro Ser Gly Asn  Val Phe Pro 
    1055                 1060                 1065             


Ser Asp  Lys Trp Met Ala Ala  Gly Val Phe Phe Gly  Lys Leu Glu 
    1070                 1075                 1080             


Arg Ile  Leu Ile Ser Lys Leu  Thr Asn Gln Tyr Ser  Ile Ser Thr 
    1085                 1090                 1095             


Ile Glu  Asp Asp Ser Ser Lys  Gln Ser Met 
    1100                 1105             


<210> 34
<211> 1468
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12b sequence"

<400> 34
Met Ala Thr Ala Val Asp Thr Ser Thr Thr Arg Ala Tyr Thr Leu Arg 
1               5                   10                  15      


Leu Ser Gly Gly Asn Asn Trp Arg Glu Leu Leu Trp Gln Thr His Val 
            20                  25                  30          


Ala Val Asn Arg Gly Ala Trp Val Trp Gly Asp Trp Leu Leu Thr Leu 
        35                  40                  45              


Arg Gly Gly Leu Pro Ala Ser Leu Ala Asp Gly Asp Ala Glu Arg Arg 
    50                  55                  60                  


Val Val Leu Ala Leu Ser Trp Leu Ser Val Glu Ser Pro Ala Ser Leu 
65                  70                  75                  80  


Ala Pro Gln Ala His Ile Val Ala Tyr Gly Ser Asp Ala Arg Asp Glu 
                85                  90                  95      


Arg Asn Arg Lys Val Thr Glu Arg Phe Arg Asp Ile Leu Arg Arg Met 
            100                 105                 110         


Gly Ile Lys Gln Gln Gln Glu Gln Glu Trp Leu Asp Ala Cys Leu Pro 
        115                 120                 125             


Ala Leu Met Ala Ser Ile Arg Glu Asp Ala Val Trp Val Asp Arg Ser 
    130                 135                 140                 


Ala Cys Phe Ala Glu Ala Gln Gln Cys Tyr Arg Gly Leu Ser Ser Glu 
145                 150                 155                 160 


Trp Ala Arg Lys Thr Leu Phe Asp Phe Leu Gly Gly Glu Asp Asp Tyr 
                165                 170                 175     


Phe Lys Pro Ser Ala Lys Glu Gly Ala Ser Ser Lys Ala Lys Asp Phe 
            180                 185                 190         


Val Gln Lys Ala Gly Arg Trp Leu Ser Arg His Trp Gly Ala Gly Lys 
        195                 200                 205             


Lys Ser Asp Pro Arg Asp Ile Ser Thr Arg Leu Gly Lys Leu Ala Gly 
    210                 215                 220                 


Val Asp Pro Lys Ala Ile Asp Gly His Thr Gly Arg Ala Ala Leu Glu 
225                 230                 235                 240 


Asp Leu Leu Arg Thr Leu Gly Ser Arg Pro Ala Gln Asn Ala Asp Ala 
                245                 250                 255     


Glu Lys Leu Tyr Arg Gln Leu Lys Arg Ala Val Gly Trp Lys Gly Arg 
            260                 265                 270         


Pro Ser Lys Gly Ala Val Ala Leu Lys Lys Ile Arg Asp Ala Glu Arg 
        275                 280                 285             


Val Pro Asn Asp Leu Trp Lys Glu Ile Ala Ser Thr Leu Arg Glu Glu 
    290                 295                 300                 


Ala Ala Val Gln Ser Ser Gln Thr Ser Asp His Ala Ala Val Pro Asp 
305                 310                 315                 320 


Trp Arg Ser His Trp Pro Ala Glu Ile Thr Gly Leu Pro Met Pro Tyr 
                325                 330                 335     


Arg Val Asp Arg Asp Tyr Ile Trp Glu His Gly Val Met Leu Asp His 
            340                 345                 350         


Ala Leu Arg Arg Val Ser Ser Ala His Thr Trp Ile Lys Arg Ala Glu 
        355                 360                 365             


Ala Glu Arg Arg Arg Phe Gln Gln Asp Ala Ala Lys Met Gly Ser Ile 
    370                 375                 380                 


Pro Glu Glu Ala Arg Asn Trp Leu Asp Ala Phe Arg Glu Arg Arg Ser 
385                 390                 395                 400 


Ser Ser Ser Gly Ala Thr Gly Asp Tyr Leu Ile Arg Glu Arg Ala Ile 
                405                 410                 415     


Asn Gly Trp Asp Lys Val Val Gln Ala Trp Glu Thr Leu Gly Pro Asn 
            420                 425                 430         


Ser Thr Arg Asp Gln Arg Ile Ala Ala Ala Arg Asp Val Gln Ala Asn 
        435                 440                 445             


Leu Asp Glu Asp Glu Lys Phe Gly Asp Ile Gln Leu Phe Ala Gly Phe 
    450                 455                 460                 


Gly Asp Glu His Val Asp Asp Pro Glu Arg Cys Leu Ala Asp Asp Arg 
465                 470                 475                 480 


Ala Thr Cys Val Trp Arg Asn Ser Ser Gly Arg Ala Asp Gly Arg Ile 
                485                 490                 495     


Leu Lys Asp Tyr Val Ala Ala Thr Val Ala Glu His Asn Gln Arg Arg 
            500                 505                 510         


Phe Lys Val Pro Ala Tyr Arg His Pro Asp Pro Leu Arg His Pro Val 
        515                 520                 525             


Phe Val Asp Tyr Gly Lys Ser Arg Trp Ser Ile Asn Tyr Ser Ala Leu 
    530                 535                 540                 


Thr Ala Ala Gln Gln Arg Arg Lys Thr Thr Gln Lys Leu Ala Gln Ala 
545                 550                 555                 560 


Lys Thr Asp Asn Thr Arg Ala Lys Leu Gln Gln Gln Leu Ala Ser Thr 
                565                 570                 575     


Ala Asp Leu Arg Ser Val Thr Leu Gly Val Trp Asp Gly Asn Arg Ile 
            580                 585                 590         


Val Lys Ile Ser Gln Arg Trp Arg Ser Lys Arg Phe Trp Arg Asp Leu 
        595                 600                 605             


Asp Leu Asp His Phe Gly Ser His Pro Ser Ala Ala Val Ser Arg Ala 
    610                 615                 620                 


Asp Arg Leu Gly Arg Val Ala Ala Arg Gln Asp Pro Gly Ala Ala Val 
625                 630                 635                 640 


Tyr Val Ala Lys Val Phe Glu Gln Gln Asp Trp Asn Gly Arg Leu Gln 
                645                 650                 655     


Val Pro Arg Arg Glu Leu Asn Arg Leu Ala Asp Val Val Tyr Gly Lys 
            660                 665                 670         


Gly Ala Asp Pro Asp Phe Gly Lys Leu Glu Arg Leu Asp Pro Arg Ala 
        675                 680                 685             


Arg Arg Leu Trp Glu Arg Leu Ser Trp Phe Leu Thr Thr Ser Ala Thr 
    690                 695                 700                 


Val Gln Pro Gln Gly Pro Trp Leu Asp Tyr Val Ala Ala Gly Leu Pro 
705                 710                 715                 720 


Ser Gly Ile Gln Tyr Thr Lys Ser Arg Ala Gly Tyr Tyr Leu Asn Tyr 
                725                 730                 735     


Asp Ala Asn His Gly Arg Lys Gly Arg Ala Arg Leu Cys Leu Ala Arg 
            740                 745                 750         


Leu Pro Gly Leu Arg Val Leu Ser Leu Asp Leu Gly His Arg Tyr Ala 
        755                 760                 765             


Ala Ala Cys Ala Val Trp Gln Thr Leu Thr Ile Glu Gln Met Thr Asn 
    770                 775                 780                 


Glu Cys Arg Gln Ala Ala His Pro Ala Pro Ser Asn Asp Asp Leu Phe 
785                 790                 795                 800 


Ile His Leu Arg His Pro Thr His Lys Pro Gln Lys Ser Gly Arg Lys 
                805                 810                 815     


Lys Gly Arg Pro Val Thr Lys Thr Thr Ile Tyr Arg Arg Ile Gly Pro 
            820                 825                 830         


Asp Lys Leu Pro Asp Gly Thr Asp His Pro Ala Pro Trp Ala Arg Leu 
        835                 840                 845             


Glu Arg Gln Phe Leu Ile Lys Leu Gln Gly Glu Asp Arg Pro Ala Arg 
    850                 855                 860                 


Tyr Ala Ser Gln Lys Glu Ile Asp Glu Val Asn Gln Phe Arg Asn Phe 
865                 870                 875                 880 


Val Gly Leu Glu Pro Ile Val Asp Arg Pro Arg Val Asp Asp Leu His 
                885                 890                 895     


Ser Asp Ala Val Arg Val Ala Arg Leu Gly Leu Arg Arg Leu Ala Asp 
            900                 905                 910         


Ala Ala Arg Ile Ala Phe Ala Met Thr Ala Ala Lys Lys Pro Ile Ser 
        915                 920                 925             


Gly Gly His Glu Val Glu Leu Thr Thr Ala Gln Arg Ile Glu Phe Leu 
    930                 935                 940                 


Gln Asp Ala Leu Leu Leu Trp Gln Ser Leu Ala Ala Ser Arg Arg Tyr 
945                 950                 955                 960 


Arg Asp Asp Trp Ala Glu Lys Leu Trp Gln Ser Trp Val Val Glu Lys 
                965                 970                 975     


Leu Gly Gly Pro Gln Pro Ala Glu Ile Ala Asp Asp Leu Pro Arg Ser 
            980                 985                 990         


Gln Arg Ala Ala Ser Leu Lys Thr  Ala Arg Gln Ser Leu  Arg Lys Val 
        995                 1000                 1005             


Ala Glu  Lys Leu Ser Asp Gly  Gln Ser Pro Ser Ala  Ala Glu Leu 
    1010                 1015                 1020             


His Arg  Leu Trp Ala Glu Arg  Trp Gln Gln Arg Gln  Thr Glu Trp 
    1025                 1030                 1035             


Arg Arg  His Leu Arg Trp Leu  Arg Arg Leu Ile Leu  Pro Arg Arg 
    1040                 1045                 1050             


Lys Asp  His Gln Gln Glu Asp  Arg Pro Leu Gln Arg  Val Gly Gly 
    1055                 1060                 1065             


Leu Ser  Val Lys Arg Ile Gln  Thr Ile Arg Gln Leu  Tyr Gln Val 
    1070                 1075                 1080             


Leu Lys  Ala Phe Arg Met Arg  Pro Glu Pro Ser Asp  Leu Arg Lys 
    1085                 1090                 1095             


Asn Ile  Pro Ala Pro Gly Asp  Arg Ser Leu Ala Ser  Phe Gly Arg 
    1100                 1105                 1110             


Arg Ile  Leu Asn His Leu Glu  Arg Leu Arg Glu Gln  Arg Ile Lys 
    1115                 1120                 1125             


Gln Leu  Ala Ser Arg Val Val  Glu Ala Ala Leu Gly  Ala Gly Arg 
    1130                 1135                 1140             


Ile Ser  Lys Pro Pro Gly Arg  Asp Arg Arg Arg Pro  Gln Gln Pro 
    1145                 1150                 1155             


Val Asp  Arg Pro Cys His Ala  Val Val Ile Glu Asn  Leu Gln His 
    1160                 1165                 1170             


Tyr Lys  Pro Glu Asp Ser Arg  Leu Arg Arg Glu Asn  Arg Gln Leu 
    1175                 1180                 1185             


Met Asp  Trp Gln Ala Arg Asn  Leu Arg Lys Tyr Ile  Val Glu Gly 
    1190                 1195                 1200             


Cys Glu  Leu His Gly Leu Leu  Phe Val Glu Val Ser  Pro Ala Tyr 
    1205                 1210                 1215             


Thr Ser  Arg Gln Asp Ser Arg  Thr Gly Ala Pro Gly  Leu Arg Cys 
    1220                 1225                 1230             


Glu Asp  Val Ser Arg Thr Ala  Leu Gln Glu Ala Ala  Arg Arg Met 
    1235                 1240                 1245             


His Ala  Ser His Ser Arg Pro  Ser Asn Ser Ser Pro  Gly Gly Ser 
    1250                 1255                 1260             


Gln Thr  Gln Phe Glu Arg Glu  Val Cys Arg Trp Ile  Asn Glu Phe 
    1265                 1270                 1275             


Lys Arg  Val Glu Gly Ser Ser  Ser Ser Leu Ser Ala  Arg Gln Ala 
    1280                 1285                 1290             


Val Leu  Lys Ala Phe Leu His  His Gln Ala Ser Ile  Pro Thr Ser 
    1295                 1300                 1305             


Leu Ser  Thr Ile Leu Leu Pro  Arg Arg Gly Gly Glu  Leu Phe Val 
    1310                 1315                 1320             


Ser Ala  Asp Pro Asp Ser Pro  Leu Ala Cys Gly Leu  Gln Ala Asp 
    1325                 1330                 1335             


Leu Asn  Ala Ala Ala Asn Ile  Gly Leu Lys Ala Leu  Thr Asp Pro 
    1340                 1345                 1350             


Asp Trp  Met Gly Ala Trp Trp  Phe Val Leu Val Asp  Arg Ala Ser 
    1355                 1360                 1365             


Gly Gln  Pro Val Glu Glu Gln  Val Gln Gly Cys Pro  Ile Trp Leu 
    1370                 1375                 1380             


Ser Cys  Gly Pro Leu Ser Asn  Ser Asn Pro Ala Thr  Ile Asp Pro 
    1385                 1390                 1395             


Ser Asp  Ser Pro Thr Ala Ala  Arg Arg Ser Asn Gly  Thr Gly Ala 
    1400                 1405                 1410             


Lys Gly  Arg Ala Arg Ala Asn  Glu Tyr Trp Trp Ser  Ser Leu Ser 
    1415                 1420                 1425             


Ala Thr  Thr Leu Pro Asp His  Lys Ala Trp Gln Pro  Thr Gln Asp 
    1430                 1435                 1440             


Tyr Trp  Arg Asp Ile Glu Gln  Arg Val Val Lys Arg  Leu Leu Arg 
    1445                 1450                 1455             


Leu Leu  Asp Gly Ser Glu Trp  Ser Glu Asp 
    1460                 1465             


<210> 35
<211> 1375
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12b sequence"

<400> 35
Met Asn Arg Ile Tyr Gln Gly Arg Val Ser Lys Ile Glu Ile Lys Asp 
1               5                   10                  15      


Ser Glu Gly Asn Phe Arg Asn Val Pro Val Gly Ser Pro Asp Thr Cys 
            20                  25                  30          


Pro Leu Trp Arg His His Arg Ile Phe Gln Asp Ala Val Asn Tyr Tyr 
        35                  40                  45              


Leu Val Ala Leu Gly Ala Leu Ala Gly Thr Gly Ser Glu Asn Ala Phe 
    50                  55                  60                  


Val Gly Leu Gly Ser Lys Asp Arg Val Ile His Asp Leu Tyr Ser Arg 
65                  70                  75                  80  


Leu Phe Asp Ser Trp Glu Arg Phe Pro Arg Asp Met His Gly Ala Ser 
                85                  90                  95      


Ser Leu Arg Asp Ser Leu Arg Arg Thr Leu Pro Gly Leu Ser Glu Arg 
            100                 105                 110         


Ala Ser Leu Gln Asp Ala Phe Asp Ala Ile Leu Ser Gly Asn Glu Ala 
        115                 120                 125             


Asn Ala Arg Glu Arg Val Leu Ser Leu Leu Ser Leu Ile Gln Asp Leu 
    130                 135                 140                 


Gly Gly Asp Ile Gln Lys Gly Ser Lys Arg Tyr Phe Pro Phe Phe Cys 
145                 150                 155                 160 


Glu Pro Ala Thr Lys Ala Thr Phe Pro Arg Ala Arg Val Gly Leu Leu 
                165                 170                 175     


Lys Val Glu Gly Lys Asp Phe Val Pro Arg Leu Leu Trp Ser Ser Asp 
            180                 185                 190         


Leu Glu Ile Ala Pro Asp Gln Val Val Glu Gln Leu Lys Phe Glu Tyr 
        195                 200                 205             


Phe Ala Asn Pro Asn Glu Ser Val Gln Pro Ile Glu Gly Asn Glu Ala 
    210                 215                 220                 


Arg Val Arg Leu Ile Glu Ala Leu Asp Asn Pro Gln Leu Gly Ile Glu 
225                 230                 235                 240 


Leu Pro Ile Glu Ile Leu Ser Asp Leu Arg Lys Arg Val His Leu Ile 
                245                 250                 255     


Glu Thr Asp Ile Arg Ile Pro Arg Tyr Phe Phe Gly Gly Ala Gly Ala 
            260                 265                 270         


Glu Leu Arg Lys Phe Arg Leu Asp Leu Phe Leu Ile Ala Ala Tyr Val 
        275                 280                 285             


Thr Pro Asp Pro Ser Ile Leu Arg Ala Leu Arg Asn Ser Phe Lys Glu 
    290                 295                 300                 


Pro Ser Ala Ser Lys Ser Ser Lys Lys Lys Asp Glu Thr Glu Glu Val 
305                 310                 315                 320 


Glu Asn Leu Leu Arg Ser Leu Gly Asp Asp Pro Leu Ile Leu Ala Arg 
                325                 330                 335     


Gly Glu Arg Gly Phe Val Phe Pro Ser Phe Thr Ser Leu Pro Thr Trp 
            340                 345                 350         


Val Gly Ala Asn Ala Gln Lys Pro Ile Trp Arg Asp Phe Asp Ile Ala 
        355                 360                 365             


Ala Phe Ala Glu Ala Leu Lys Ser Leu Asn Gln Phe Thr Ala Lys Thr 
    370                 375                 380                 


Glu Glu Arg Glu Glu Lys Leu Lys Lys Ala Glu Glu Thr Leu His Tyr 
385                 390                 395                 400 


Met Leu Gly Ile Ser Asp Ala Ile Pro Arg Ser Ser Asp Ser Glu Thr 
                405                 410                 415     


Glu Glu Gln Ala Pro Ser Arg Pro Gly Lys Asp Pro Arg Trp Pro Leu 
            420                 425                 430         


Val Ala Gln Leu Glu Lys Glu Leu Gly Glu Asn Leu Ser Glu Gly Thr 
        435                 440                 445             


Trp Gln Leu Ser Arg Ser Ala Met Arg Gly Leu Arg Asp Ile Ile Gly 
    450                 455                 460                 


Leu Trp Arg Lys His Pro Gly Ala Ser Val Val Thr Leu Gln Lys Asp 
465                 470                 475                 480 


Val Lys Thr Tyr Gln Ala Asp Glu Lys His Lys Arg Glu Ile Gly Ser 
                485                 490                 495     


Val Gln Leu Phe Leu Leu Leu Cys Glu Glu Arg Tyr His Ala Leu Trp 
            500                 505                 510         


Gln Thr Glu Thr Asp Asp Glu Arg Gly Asp Glu Ser Glu Glu Asn Asp 
        515                 520                 525             


Asp Pro Ala Arg Ile Leu Ser Asp Ala Ile Glu Val His Gln Ile Arg 
    530                 535                 540                 


Arg Glu Val Glu Arg Phe Arg Glu Pro Ile Arg Leu Thr Pro Ala Glu 
545                 550                 555                 560 


Pro Val Phe Ser Arg Arg Leu Phe Met Phe Ser Asp Leu Thr Asp Lys 
                565                 570                 575     


Leu Ala Lys Val Lys Phe Gly Glu Thr Thr Glu Glu Asn Ser Glu Val 
            580                 585                 590         


Lys Ser Gln Phe Val Glu Ala Ala Ile Ala Leu Lys Glu Gly Glu Asn 
        595                 600                 605             


Leu Lys Glu Ala Arg Val Arg Ile Thr Phe Ser Ala Pro Arg Leu His 
    610                 615                 620                 


Arg Asp Glu Leu Leu Gly Gly Ala Glu Ser Arg Trp Leu Gln Pro Ile 
625                 630                 635                 640 


Thr Ala Ala Leu Gly Phe Ser Asn Pro Ala Pro Ser Val Lys Phe Asp 
                645                 650                 655     


Ser Ala Val Ala Leu Met Pro Asp His Met Asp Asp Gly Arg Ile Arg 
            660                 665                 670         


His Leu Leu Asn Phe Pro Val Asn Phe Asp Ser Ala Trp Leu His Gln 
        675                 680                 685             


Ser Ile Gly Lys Ala Asp Leu Trp Lys Ser Gln Phe Asn Gly Thr Lys 
    690                 695                 700                 


Asp Lys Asn Leu His Leu His Trp Ala Gly Thr Ala Arg Asp Thr Thr 
705                 710                 715                 720 


Arg Lys Asn Thr Trp Trp Glu Asn Arg Thr Ile Ile Glu Asn Gly Phe 
                725                 730                 735     


Thr Val Leu Ser Asn Asp Leu Gly Gln Arg Ser Ala Gly Ala Trp Ala 
            740                 745                 750         


Leu Leu Lys Val Thr Cys Ser Arg Pro Asp Thr Lys His Pro Val Arg 
        755                 760                 765             


Ser Ile Gly His Asp Gly Thr Arg Glu Trp Phe Ala Thr Val Leu Ala 
    770                 775                 780                 


Thr Gly Ile His Arg Leu Pro Gly Glu Asp Gln Arg Ile Leu Lys Asn 
785                 790                 795                 800 


Gly Lys Trp Ala Thr Glu Gln Ser Gly Lys Lys Gly Arg Asn Ala Thr 
                805                 810                 815     


Phe Ser Glu Tyr Glu Ala Ala Cys Val Leu Ala Lys Asn Leu Gly Cys 
            820                 825                 830         


Glu Ser Val Glu Asn Trp Leu Gly Met Ser Gly Glu Lys Ser Tyr Pro 
        835                 840                 845             


Ala Leu Asn Asp Gln Leu Val Lys Ile Ala Asn Arg Arg Ile Thr Arg 
    850                 855                 860                 


Leu Gly Thr Tyr His Arg Trp Ser Cys Phe Ser Pro Glu Lys Phe Glu 
865                 870                 875                 880 


Asp Pro Ala Arg Arg Ala Asn Val Ile Gly Gly Gln Leu Ala Glu Leu 
                885                 890                 895     


Ser Ala Tyr Gln Asp Glu Asn Val Thr Val Ser Ala Asp Ile Leu Lys 
            900                 905                 910         


Ser Gly Asp Phe Glu Gly Phe Arg His Arg Ala Gly Ala Ala Phe Glu 
        915                 920                 925             


Ala Leu Arg Thr Glu Leu Glu Val His Leu Val Asn Leu Ala Asn Leu 
    930                 935                 940                 


Thr Ala Pro Leu Arg Gln Lys Val Trp Ser Trp Gln Lys Arg Pro Asp 
945                 950                 955                 960 


Ser Ser Gly Tyr Gly Asp Leu Leu Met Val Asp Leu Asp Asp Cys His 
                965                 970                 975     


Pro Lys Ile Arg Gly Gln Arg Gly Leu Ser Met Ala Arg Leu Glu Gln 
            980                 985                 990         


Leu Glu Gly Leu Arg Arg Leu Phe  Leu Arg Tyr Asn Arg  Ser Leu Asp 
        995                 1000                 1005             


Arg Ser  Pro Gly Ile Pro Ala  Lys Phe Gly Arg Glu  Asp Val Gly 
    1010                 1015                 1020             


Arg Thr  Ser Gly Glu Pro Cys  Gln Ala Leu Leu Val  Lys Ile Asp 
    1025                 1030                 1035             


Arg Met  Lys Glu Gln Arg Val  Asn Gln Thr Ala His  Leu Ile Leu 
    1040                 1045                 1050             


Ala Gln  Ala Leu Gly Val Arg  Leu Cys Pro His Arg  Ile Glu Glu 
    1055                 1060                 1065             


Asn Glu  Arg Lys Ser Arg Asp  Leu His Gly Glu Tyr  Glu Lys Ile 
    1070                 1075                 1080             


Pro Gly  Arg Glu Pro Val Asp  Phe Ile Val Ile Glu  Asp Leu Ser 
    1085                 1090                 1095             


Arg Tyr  Leu Ser Ser Gln Gly  Arg Ala Pro Ser Glu  Asn Ser Arg 
    1100                 1105                 1110             


Leu Met  Lys Trp Ala His Arg  Ala Val Arg Asp Lys  Leu Lys Met 
    1115                 1120                 1125             


Leu Ala  Glu Glu Pro Phe Gly  Ile Pro Val Val Glu  Thr Val Pro 
    1130                 1135                 1140             


Ala Tyr  Ser Ser Arg Phe His  Ala Leu Asn Gly Gln  Ala Gly Ser 
    1145                 1150                 1155             


Arg Leu  His Glu Leu His Glu  Leu Glu Ala Tyr Gln  Gln Gln Ser 
    1160                 1165                 1170             


Leu Ile  Asn Leu Ala Ala Lys  Thr Asp Phe Gln Asn  Arg Asp Arg 
    1175                 1180                 1185             


Ser Lys  Ala Ala Gly Glu Leu  Phe Glu Gln Phe Gln  Ala Leu Ala 
    1190                 1195                 1200             


Lys Leu  Asn Glu Arg Arg Arg  Ala Glu Gly Lys Lys  Val Pro Arg 
    1205                 1210                 1215             


Thr Leu  Tyr Tyr Pro Lys Ser  Gly Gly Pro Leu Phe  Leu Ala Ser 
    1220                 1225                 1230             


Arg Asp  Gly Asp Thr Ile His  Ala Asp Val Asn Ala  Ala Ile Asn 
    1235                 1240                 1245             


Leu Gly  Leu Arg Ala Ile Ala  Ala Pro Ala Cys Ile  Asp Ile His 
    1250                 1255                 1260             


Arg Arg  Leu Arg Ala Thr Lys  Glu Lys Glu Val Tyr  Arg Pro Arg 
    1265                 1270                 1275             


Val Gly  Asn Ala Arg Glu Lys  Ser Ala Phe Ser Lys  Asp Asp Ile 
    1280                 1285                 1290             


Ile Gln  Pro Ser Gly Ala Pro  Ser Lys Lys Phe Ala  Ser Ser Ser 
    1295                 1300                 1305             


Ser Pro  Asn Phe Phe Tyr Glu  Pro Glu Asp Leu Lys  Gln Ala Asn 
    1310                 1315                 1320             


Gly Glu  Pro Leu Phe Asp Arg  Ala Met Phe Gly Glu  Tyr Ser Leu 
    1325                 1330                 1335             


Val Ser  Gly Val Ser Leu Trp  Ser Met Val Asn Asn  Ala Ile Tyr 
    1340                 1345                 1350             


Ile Arg  Cys Val Glu Leu Asn  Arg Thr Arg Leu His  Gly Lys Asp 
    1355                 1360                 1365             


Pro Asp  Asp Gln Ile Pro Met  
    1370                 1375 


<210> 36
<211> 1254
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12b sequence"

<400> 36
Met Ser Ile Thr Arg Ser Ile Lys Val Lys Leu Ile Val Pro Arg Asp 
1               5                   10                  15      


Ala Ser Leu Glu Ala Arg Gln Leu Arg Glu Gly Leu Trp Ala Thr His 
            20                  25                  30          


Leu Phe Val Asn Asp Gly Cys His Tyr Tyr Glu Arg Leu Leu Leu Glu 
        35                  40                  45              


Phe Arg Gln Arg Asp Val Cys Val Gly Lys Asp Asp Ala Gly Lys Asp 
    50                  55                  60                  


Val Ile Val Pro Ala Ala Glu Trp Ala Asp Arg Leu Arg Ala Arg Leu 
65                  70                  75                  80  


Gly Arg Asn Gly Met Val Pro Ser His Ile Glu Ala Ala Leu Pro Ile 
                85                  90                  95      


Phe Arg Glu Leu Tyr Glu Asn Met Val Pro Ser Ala Leu Lys Ala Lys 
            100                 105                 110         


Ser Gly Thr Gly Gln Ala Gly Arg Ser Trp His Ser Lys Leu Val Ser 
        115                 120                 125             


Pro Thr Ser Arg Gly Gly Glu Ala Ser Ala Ala Arg Ile Asp Val Leu 
    130                 135                 140                 


Arg Pro Leu Leu Pro Val Ser Gly Asp Asp Pro Ala Phe Glu Pro Ala 
145                 150                 155                 160 


Ala Arg Ala Leu Ile Glu Glu Ala Gly Asp Glu Leu Leu Thr Ser Thr 
                165                 170                 175     


Gly Arg Cys Pro Ala Trp Val Thr Ala Tyr Arg Lys Gly Pro Glu Gly 
            180                 185                 190         


Ser Ala Trp Val Glu Lys Leu Arg Ile Gln Leu Arg Glu Ala Val Glu 
        195                 200                 205             


Ala Gly Asp Phe Asp Pro Pro Ser Asp Pro Gln Ile Leu Ala Ala Gly 
    210                 215                 220                 


Ala Val Pro Ala Ala Pro Pro Leu Gly Ala Gly Ile Asp Ala Leu Arg 
225                 230                 235                 240 


Pro Leu Leu Pro Leu Leu Gly Gly Asp Pro Ala Phe Glu Pro Ala Ala 
                245                 250                 255     


Arg Ala Leu Val Glu Asp Ile Gly Asp Glu Leu Phe Thr Ser Thr Gly 
            260                 265                 270         


Arg Pro Pro Thr Trp Val Thr Ala His Pro Thr Trp Val Arg Ala His 
        275                 280                 285             


Arg Lys Asp Ala Glu Cys Leu Glu Ala Ala Asp Asp Phe Lys Trp Val 
    290                 295                 300                 


Glu Arg Leu Arg Gln Arg Leu Arg Asp Asp Ala Lys Ala Gly Lys Phe 
305                 310                 315                 320 


Glu Gln Pro Leu His Glu Arg Leu Gly Ala Leu Gly Ala Leu Pro Val 
                325                 330                 335     


Ala Lys Pro Ile Gly Ala Gly Arg Val Val Ser Arg Ala Asp Leu Thr 
            340                 345                 350         


Val Phe Glu Arg Gly Ala Met Glu Leu Ala Ile Glu His Leu Ile Gly 
        355                 360                 365             


Trp Glu Ser Ala Gly His Arg Ala Arg Ala Gln Tyr Val Glu Arg Lys 
    370                 375                 380                 


Lys Arg His Asp Asp Leu Leu Gln Trp Ile Glu Ala Glu Ala Pro Asp 
385                 390                 395                 400 


Ala Leu Leu Ala Val Arg Ala Tyr Glu Ala Ala Arg Thr Ile His Leu 
                405                 410                 415     


Ala Thr Leu Gly Glu Leu Gly Ala Ala Pro Gln Tyr Thr Leu Arg Leu 
            420                 425                 430         


Arg Glu Ile Arg Pro Trp Arg Lys Leu Arg Glu Trp Leu Leu Gln Asn 
        435                 440                 445             


Pro Asp Ala Thr Ile Asp Glu Arg Arg Arg Arg Leu Ala Thr Met Gln 
    450                 455                 460                 


Thr Asn Asp Pro Arg Gly Tyr Gly Gly Glu Ala Leu Ala Trp Leu Ala 
465                 470                 475                 480 


Ala Pro Glu Arg Arg Ala Leu Val Glu His Pro Ala Gly Asp Val Val 
                485                 490                 495     


Thr Arg Ile Ala Val Leu Asn Ile Arg Lys Ser Ile Leu Asp Arg Ser 
            500                 505                 510         


Arg Leu Phe Pro Thr Cys Thr Leu Ala Asp Pro Val Glu His Pro Arg 
        515                 520                 525             


Phe Ala Lys Phe Gly Lys Pro Gly Asp Lys Asn Ser Ala Gly Tyr Ala 
    530                 535                 540                 


Leu Ala Val Asp Gly Val Arg Arg Glu Ala Ile Ile Lys Ile Leu Val 
545                 550                 555                 560 


Pro Arg Gln Asp Gly Leu Leu Val Pro Thr Asp Leu Arg Val Pro Phe 
                565                 570                 575     


Ala Pro Ser Gly Gln Met Arg Asp Leu Arg Ala Ser Gly Leu Asp Ile 
            580                 585                 590         


Ser Tyr Glu Arg Gln Asp Gly Arg Gly Arg Gln Ala Ala Lys Leu Gln 
        595                 600                 605             


Gly Gly Asn Leu Met Phe Asp Arg Thr His Phe Ala Arg Cys Gly Ala 
    610                 615                 620                 


Pro Gly Pro Glu Ala Leu Gly Ser Val Trp Ile Lys Val Ala Leu Asp 
625                 630                 635                 640 


Leu Ser Ser Pro Ala Ala Ser Leu Ala Met Lys Thr Ala Thr Pro Val 
                645                 650                 655     


Arg Thr Tyr Leu Ser Thr Ala Val Arg Gly Arg Pro Glu Ser Thr Lys 
            660                 665                 670         


Tyr Glu Lys Ala Ala Pro Pro Glu Gly Phe Arg Val Leu Ser Val His 
        675                 680                 685             


Met Gly Leu Arg Thr Ala Ala Thr Ala Ser Met Leu Arg Phe Gly Ala 
    690                 695                 700                 


Pro Glu Glu Gly Gly His Glu Val Pro Val Ser Gly Leu Ala Gly Glu 
705                 710                 715                 720 


Thr Leu Val Ala Phe His Glu Arg Thr Val Thr Met Lys Leu Pro Gly 
                725                 730                 735     


Glu Asp Pro Asp Thr Arg Thr Glu Ala Asn Arg Gly Val Ala Lys Arg 
            740                 745                 750         


Glu Leu Arg Gly Leu Gly Arg Gly Ile Gly Cys Leu Lys Ala Ile Arg 
        755                 760                 765             


Arg Ala Ser Ala Ser Ala Thr Pro Glu Asp Arg Ala Glu Ala Leu Val 
    770                 775                 780                 


Ile Ile Glu Thr His Val Gly Gln Gly Asp Arg His Gly Trp Ala Pro 
785                 790                 795                 800 


Ala Glu Ala Val Gly Arg Leu Asp Pro His Gly Asp Pro Asp Asp Trp 
                805                 810                 815     


Lys Thr Ala Cys Ala Ala Leu Tyr Ala Ala Val Glu Ala Asp Leu Gly 
            820                 825                 830         


Val Ala Ile Ser Ser Trp Arg Lys Ala Ala Arg Ala Gly Gly Ala Thr 
        835                 840                 845             


Gly Met Leu Gly Gly Lys Ser Leu Trp Ala Val Asp His Leu Glu Arg 
    850                 855                 860                 


Ser Phe Arg Phe Leu Arg Ser Trp Asp Leu Arg Ala Arg Pro His Asp 
865                 870                 875                 880 


Gly Asp Pro Arg Arg Pro Arg Pro Gly Tyr Ala Ser Lys Leu Leu His 
                885                 890                 895     


His Ile Asp Gly Val Lys Asp Asp Arg Val Lys Thr Thr Ala Asp Arg 
            900                 905                 910         


Ile Val Gln Ala Ala Cys Gly Arg Ala Trp Ile Gly Gly Pro Thr Val 
        915                 920                 925             


Lys Arg Gly Thr Gln Asp Val Arg Leu Pro Gly Arg Trp Glu Gln Arg 
    930                 935                 940                 


Gly Pro Arg Ala Asp Leu Ile Leu Leu Pro Asp Leu Thr His Phe Arg 
945                 950                 955                 960 


Phe Arg Ser Asp Arg Pro Arg Ala Glu Asn Ser Arg Leu Met Arg Trp 
                965                 970                 975     


Ala His Arg Gln Leu Ala Ile Tyr Val Arg Met Gln Ala Glu Val Glu 
            980                 985                 990         


Gly Ile Leu Val Ala Asp Thr Gly  Ala Ala Phe Thr Thr  Arg Phe Asp 
        995                 1000                 1005             


Ala Trp  Thr Gly Ala Pro Gly  Val Arg Cys Glu Pro  Val Thr Ala 
    1010                 1015                 1020             


Asp His  Leu Arg Gly Ile Ala  Lys Arg Glu Asp Tyr  Trp Leu Ala 
    1025                 1030                 1035             


Arg Leu  Leu Arg Glu Gly Ala  Leu Lys His Leu Arg  Ile Asp Pro 
    1040                 1045                 1050             


Ala Ser  Leu Arg Val Asp Asp  Leu Val Pro Met Asp  His Gly Lys 
    1055                 1060                 1065             


Ile Leu  Val Ala Leu Asp Gly  Val Asp Leu Pro Gly  Leu Arg Ile 
    1070                 1075                 1080             


Leu Asp  Thr Asp Val Asn Ala  Ser Gln Gly Leu Gly  Arg Arg Tyr 
    1085                 1090                 1095             


Ile Glu  Gly His Gly Leu Ala  Tyr Arg Leu Pro Gly  Ala Arg Val 
    1100                 1105                 1110             


Pro Arg  Gly Glu Gly Glu Arg  Glu Ala Ala Val Val  His Ile Lys 
    1115                 1120                 1125             


Gly Lys  Arg Leu Ala Ser Ala  Met Gly Gly Thr Val  Val Val Leu 
    1130                 1135                 1140             


Arg Ala  Ser Glu Gly Pro Gly  Asp Ile Thr Trp Thr  Ala Glu Val 
    1145                 1150                 1155             


Tyr Asp  Arg Pro Gln Gly Ala  Arg Lys Ala Leu Gly  Leu Ser Leu 
    1160                 1165                 1170             


Ala Ala  Phe Asn Ser Ile Ala  Thr Ala Ala Val Asp  Asp Glu Gly 
    1175                 1180                 1185             


Pro Ala  Pro Glu Asn Asp Asp  Glu Ala Leu Glu Glu  Glu Ala Glu 
    1190                 1195                 1200             


Glu Ala  Leu Gly Ile Ala Thr  Gly Glu Arg Ile Val  Phe Phe Arg 
    1205                 1210                 1215             


Asp Pro  Ser Gly Ala Val Ala  Gly Gly Gly Trp Leu  Glu Ala Ser 
    1220                 1225                 1230             


Ala Phe  Trp Gly Ile Ala Asn  Arg Met Val Thr Asp  Arg Leu Arg 
    1235                 1240                 1245             


Glu Leu  Gly Arg Leu Gly 
    1250                 


<210> 37
<211> 1388
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12b sequence"

<400> 37
Met Ser Leu Asn Arg Ile Tyr Gln Gly Arg Val Ala Ala Val Glu Thr 
1               5                   10                  15      


Gly Thr Ala Leu Ala Lys Gly Asn Val Glu Trp Met Pro Ala Ala Gly 
            20                  25                  30          


Gly Asp Glu Val Leu Trp Gln His His Glu Leu Phe Gln Ala Ala Ile 
        35                  40                  45              


Asn Tyr Tyr Leu Val Ala Leu Leu Ala Leu Ala Asp Lys Asn Asn Pro 
    50                  55                  60                  


Val Leu Gly Pro Leu Ile Ser Gln Met Asp Asn Pro Gln Ser Pro Tyr 
65                  70                  75                  80  


His Val Trp Gly Ser Phe Arg Arg Gln Gly Arg Gln Arg Thr Gly Leu 
                85                  90                  95      


Ser Gln Ala Val Ala Pro Tyr Ile Thr Pro Gly Asn Asn Ala Pro Thr 
            100                 105                 110         


Leu Asp Glu Val Phe Arg Ser Ile Leu Ala Gly Asn Pro Thr Asp Arg 
        115                 120                 125             


Ala Thr Leu Asp Ala Ala Leu Met Gln Leu Leu Lys Ala Cys Asp Gly 
    130                 135                 140                 


Ala Gly Ala Ile Gln Gln Glu Gly Arg Ser Tyr Trp Pro Lys Phe Cys 
145                 150                 155                 160 


Asp Pro Asp Ser Thr Ala Asn Phe Ala Gly Asp Pro Ala Met Leu Arg 
                165                 170                 175     


Arg Glu Gln His Arg Leu Leu Leu Pro Gln Val Leu His Asp Pro Ala 
            180                 185                 190         


Ile Thr His Asp Ser Pro Ala Leu Gly Ser Phe Asp Thr Tyr Ser Ile 
        195                 200                 205             


Ala Thr Pro Asp Thr Arg Thr Pro Gln Leu Thr Gly Pro Lys Ala Arg 
    210                 215                 220                 


Ala Arg Leu Glu Gln Ala Ile Thr Leu Trp Arg Val Arg Leu Pro Glu 
225                 230                 235                 240 


Ser Ala Ala Asp Phe Asp Arg Leu Ala Ser Ser Leu Lys Lys Ile Pro 
                245                 250                 255     


Asp Asp Asp Ser Arg Leu Asn Leu Gln Gly Tyr Val Gly Ser Ser Ala 
            260                 265                 270         


Lys Gly Glu Val Gln Ala Arg Leu Phe Ala Leu Leu Leu Phe Arg His 
        275                 280                 285             


Leu Glu Arg Ser Ser Phe Thr Leu Gly Leu Leu Arg Ser Ala Thr Pro 
    290                 295                 300                 


Pro Pro Lys Asn Ala Glu Thr Pro Pro Pro Ala Gly Val Pro Leu Pro 
305                 310                 315                 320 


Ala Ala Ser Ala Ala Asp Pro Val Arg Ile Ala Arg Gly Lys Arg Ser 
                325                 330                 335     


Phe Val Phe Arg Ala Phe Thr Ser Leu Pro Cys Trp His Gly Gly Asp 
            340                 345                 350         


Asn Ile His Pro Thr Trp Lys Ser Phe Asp Ile Ala Ala Phe Lys Tyr 
        355                 360                 365             


Ala Leu Thr Val Ile Asn Gln Ile Glu Glu Lys Thr Lys Glu Arg Gln 
    370                 375                 380                 


Lys Glu Cys Ala Glu Leu Glu Thr Asp Phe Asp Tyr Met His Gly Arg 
385                 390                 395                 400 


Leu Ala Lys Ile Pro Val Lys Tyr Thr Thr Gly Glu Ala Glu Pro Pro 
                405                 410                 415     


Pro Ile Leu Ala Asn Asp Leu Arg Ile Pro Leu Leu Arg Glu Leu Leu 
            420                 425                 430         


Gln Asn Ile Lys Val Asp Thr Ala Leu Thr Asp Gly Glu Ala Val Ser 
        435                 440                 445             


Tyr Gly Leu Gln Arg Arg Thr Ile Arg Gly Phe Arg Glu Leu Arg Arg 
    450                 455                 460                 


Ile Trp Arg Gly His Ala Pro Ala Gly Thr Val Phe Ser Ser Glu Leu 
465                 470                 475                 480 


Lys Glu Lys Leu Ala Gly Glu Leu Arg Gln Phe Gln Thr Asp Asn Ser 
                485                 490                 495     


Thr Thr Ile Gly Ser Val Gln Leu Phe Asn Glu Leu Ile Gln Asn Pro 
            500                 505                 510         


Lys Tyr Trp Pro Ile Trp Gln Ala Pro Asp Val Glu Thr Ala Arg Gln 
        515                 520                 525             


Trp Ala Asp Ala Gly Phe Ala Asp Asp Pro Leu Ala Ala Leu Val Gln 
    530                 535                 540                 


Glu Ala Glu Leu Gln Glu Asp Ile Asp Ala Leu Lys Ala Pro Val Lys 
545                 550                 555                 560 


Leu Thr Pro Ala Asp Pro Glu Tyr Ser Arg Arg Gln Tyr Asp Phe Asn 
                565                 570                 575     


Ala Val Ser Lys Phe Gly Ala Gly Ser Arg Ser Ala Asn Arg His Glu 
            580                 585                 590         


Pro Gly Gln Thr Glu Arg Gly His Asn Thr Phe Thr Thr Glu Ile Ala 
        595                 600                 605             


Ala Arg Asn Ala Ala Asp Gly Asn Arg Trp Arg Ala Thr His Val Arg 
    610                 615                 620                 


Ile His Tyr Ser Ala Pro Arg Leu Leu Arg Asp Gly Leu Arg Arg Pro 
625                 630                 635                 640 


Asp Thr Asp Gly Asn Glu Ala Leu Glu Ala Val Pro Trp Leu Gln Pro 
                645                 650                 655     


Met Met Glu Ala Leu Ala Pro Leu Pro Thr Leu Pro Gln Asp Leu Thr 
            660                 665                 670         


Gly Met Pro Val Phe Leu Met Pro Asp Val Thr Leu Ser Gly Glu Arg 
        675                 680                 685             


Arg Ile Leu Leu Asn Leu Pro Val Thr Leu Glu Pro Ala Ala Leu Val 
    690                 695                 700                 


Glu Gln Leu Gly Asn Ala Gly Arg Trp Gln Asn Gln Phe Phe Gly Ser 
705                 710                 715                 720 


Arg Glu Asp Pro Phe Ala Leu Arg Trp Pro Ala Asp Gly Ala Val Lys 
                725                 730                 735     


Thr Ala Lys Gly Lys Thr His Ile Pro Trp His Gln Asp Arg Asp His 
            740                 745                 750         


Phe Thr Val Leu Gly Val Asp Leu Gly Thr Arg Asp Ala Gly Ala Leu 
        755                 760                 765             


Ala Leu Leu Asn Val Thr Ala Gln Lys Pro Ala Lys Pro Val His Arg 
    770                 775                 780                 


Ile Ile Gly Glu Ala Asp Gly Arg Thr Trp Tyr Ala Ser Leu Ala Asp 
785                 790                 795                 800 


Ala Arg Met Ile Arg Leu Pro Gly Glu Asp Ala Arg Leu Phe Val Arg 
                805                 810                 815     


Gly Lys Leu Val Gln Glu Pro Tyr Gly Glu Arg Gly Arg Asn Ala Ser 
            820                 825                 830         


Leu Leu Glu Trp Glu Asp Ala Arg Asn Ile Ile Leu Arg Leu Gly Gln 
        835                 840                 845             


Asn Pro Asp Glu Leu Leu Gly Ala Asp Pro Arg Arg His Ser Tyr Pro 
    850                 855                 860                 


Glu Ile Asn Asp Lys Leu Leu Val Ala Leu Arg Arg Ala Gln Ala Arg 
865                 870                 875                 880 


Leu Ala Arg Leu Gln Asn Arg Ser Trp Arg Leu Arg Asp Leu Ala Glu 
                885                 890                 895     


Ser Asp Lys Ala Leu Asp Glu Ile His Ala Glu Arg Ala Gly Glu Lys 
            900                 905                 910         


Pro Ser Pro Leu Pro Pro Leu Ala Arg Asp Asp Ala Ile Lys Ser Thr 
        915                 920                 925             


Asp Glu Ala Leu Leu Ser Gln Arg Asp Ile Ile Arg Arg Ser Phe Val 
    930                 935                 940                 


Gln Ile Ala Asn Leu Ile Leu Pro Leu Arg Gly Arg Arg Trp Glu Trp 
945                 950                 955                 960 


Arg Pro His Val Glu Val Pro Asp Cys His Ile Leu Ala Gln Ser Asp 
                965                 970                 975     


Pro Gly Thr Asp Asp Thr Lys Arg Leu Val Ala Gly Gln Arg Gly Ile 
            980                 985                 990         


Ser His Glu Arg Ile Glu Gln Ile  Glu Glu Leu Arg Arg  Arg Cys Gln 
        995                 1000                 1005             


Ser Leu  Asn Arg Ala Leu Arg  His Lys Pro Gly Glu  Arg Pro Val 
    1010                 1015                 1020             


Leu Gly  Arg Pro Ala Lys Gly  Glu Glu Ile Ala Asp  Pro Cys Pro 
    1025                 1030                 1035             


Ala Leu  Leu Glu Lys Ile Asn  Arg Leu Arg Asp Gln  Arg Val Asp 
    1040                 1045                 1050             


Gln Thr  Ala His Ala Ile Leu  Ala Ala Ala Leu Gly  Val Arg Leu 
    1055                 1060                 1065             


Arg Ala  Pro Ser Lys Asp Arg  Ala Glu Arg Arg His  Arg Asp Ile 
    1070                 1075                 1080             


His Gly  Glu Tyr Glu Arg Phe  Arg Ala Pro Ala Asp  Phe Val Val 
    1085                 1090                 1095             


Ile Glu  Asn Leu Ser Arg Tyr  Leu Ser Ser Gln Asp  Arg Ala Arg 
    1100                 1105                 1110             


Ser Glu  Asn Thr Arg Leu Met  Gln Trp Cys His Arg  Gln Ile Val 
    1115                 1120                 1125             


Gln Lys  Leu Arg Gln Leu Cys  Glu Thr Tyr Gly Ile  Pro Val Leu 
    1130                 1135                 1140             


Ala Val  Pro Ala Ala Tyr Ser  Ser Arg Phe Ser Ser  Arg Asp Gly 
    1145                 1150                 1155             


Ser Ala  Gly Phe Arg Ala Val  His Leu Thr Pro Asp  His Arg His 
    1160                 1165                 1170             


Arg Met  Pro Trp Ser Arg Ile  Leu Ala Arg Leu Lys  Ala His Glu 
    1175                 1180                 1185             


Glu Asp  Gly Lys Arg Leu Glu  Lys Thr Val Leu Asp  Glu Ala Arg 
    1190                 1195                 1200             


Ala Val  Arg Gly Leu Phe Asp  Arg Leu Asp Arg Phe  Asn Ala Gly 
    1205                 1210                 1215             


His Val  Pro Gly Lys Pro Trp  Arg Thr Leu Leu Ala  Pro Leu Pro 
    1220                 1225                 1230             


Gly Gly  Pro Val Phe Val Pro  Leu Gly Asp Ala Thr  Pro Met Gln 
    1235                 1240                 1245             


Ala Asp  Leu Asn Ala Ala Ile  Asn Ile Ala Leu Arg  Gly Ile Ala 
    1250                 1255                 1260             


Ala Pro  Asp Arg His Asp Ile  His His Arg Leu Arg  Ala Glu Asn 
    1265                 1270                 1275             


Lys Lys  Arg Ile Leu Ser Leu  Arg Leu Gly Thr Gln  Arg Glu Lys 
    1280                 1285                 1290             


Ala Arg  Trp Pro Gly Gly Ala  Pro Ala Val Thr Leu  Ser Thr Pro 
    1295                 1300                 1305             


Asn Asn  Gly Ala Ser Pro Glu  Asp Ser Asp Ala Leu  Pro Glu Arg 
    1310                 1315                 1320             


Val Ser  Asn Leu Phe Val Asp  Ile Ala Gly Val Ala  Asn Phe Glu 
    1325                 1330                 1335             


Arg Val  Thr Ile Glu Gly Val  Ser Gln Lys Phe Ala  Thr Gly Arg 
    1340                 1345                 1350             


Gly Leu  Trp Ala Ser Val Lys  Gln Arg Ala Trp Asn  Arg Val Ala 
    1355                 1360                 1365             


Arg Leu  Asn Glu Thr Val Thr  Asp Asn Asn Arg Asn  Glu Glu Glu 
    1370                 1375                 1380             


Asp Asp  Ile Pro Met 
    1385             


<210> 38
<211> 1172
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12b sequence"

<400> 38
Met Pro Thr Arg Thr Ile Asn Leu Lys Leu Gln Ile Ser Pro Lys Thr 
1               5                   10                  15      


Asp Glu Gly Arg Lys Ile Arg Ser Ala Leu Trp Thr Thr His Ser Glu 
            20                  25                  30          


Ile Asn Lys Ala Val Ala Glu Ile Glu Lys Leu Leu Leu Leu Cys Arg 
        35                  40                  45              


Gly Glu Lys Tyr Tyr Thr Thr Asn Ser Lys Asp Glu Glu Val Glu Val 
    50                  55                  60                  


Pro Glu Pro Gln Val Lys Thr Asp Ala Leu Glu Met Ala Arg Ala Val 
65                  70                  75                  80  


Gln Ala Lys Asn Gly Lys Ala Gly Thr Gly Ser Asp Glu Glu Val Leu 
                85                  90                  95      


Ser Ala Leu Arg Met Leu Tyr Glu Ala Thr Val Pro Ser Ser Val Leu 
            100                 105                 110         


Asp Asp Lys Gly Lys Pro Leu Ser Gly Asp Ala Gln Ser Ile Gly Gly 
        115                 120                 125             


Ser Tyr Ala Gly Pro Ile Cys Asp Pro Glu Thr Cys Arg Ile Lys Asp 
    130                 135                 140                 


Val Asp Arg Leu Phe Glu Ser Gly Pro Phe Ala Glu Thr Ala Ser Lys 
145                 150                 155                 160 


Lys Phe Thr Gln Leu Pro Ala Trp Phe Asn Glu Val Thr Lys Lys Asn 
                165                 170                 175     


Phe Asn Lys Asp Glu Pro Glu Lys Phe Val Lys Val Gly Lys Asp Lys 
            180                 185                 190         


Asp Glu Lys Phe Tyr Glu Ile Asp Leu Arg Gln Ala Asp Ala Trp Tyr 
        195                 200                 205             


Glu Ser Pro Glu Val Lys Asp Ile Val Ser Lys Asn Lys Ala Phe Asn 
    210                 215                 220                 


Lys Asp Lys Trp Trp Lys Asn Lys Arg Asp Gly Val Asp Thr Trp Ala 
225                 230                 235                 240 


Ala Glu Phe Val Lys Lys Gln Phe Asp Leu Arg Lys Asp Val Arg Val 
                245                 250                 255     


Ser Ile Arg Glu Glu Leu Trp Asp Arg Leu Gly Leu Leu Pro Leu Gly 
            260                 265                 270         


Ser Leu Tyr Phe Lys Lys Pro Val Gly Asn Lys Trp Asn Arg Met Ala 
        275                 280                 285             


Phe Arg Leu Ala Ile Ala His Leu Leu Ser Trp Glu Ser Trp Asn His 
    290                 295                 300                 


Gln Thr Leu Ala Glu Tyr Thr Lys Tyr Thr Lys Tyr Lys Asp Gly Leu 
305                 310                 315                 320 


Ile Glu Leu Ala Gly Ala Ser Arg Ser Leu Glu Val Arg Phe Glu Pro 
                325                 330                 335     


Leu Arg Gln Tyr Gln Lys Glu Arg His Glu Glu Leu Ser Arg Thr Ser 
            340                 345                 350         


Phe Val Asp Asp Asp Arg Pro Phe Thr Ile Gly Ala Arg Met Ile Arg 
        355                 360                 365             


Ala Trp Gly Arg Val Arg Glu Ala Trp Arg Asn Lys Gly Asp Gly Ile 
    370                 375                 380                 


Asp Glu Arg Arg Gln Ile Leu Ala Asp Leu Gln Thr Glu Leu Lys Gly 
385                 390                 395                 400 


Lys Phe Gly Asp Pro His Leu Phe Leu Trp Leu Ala Glu Ala Gly Arg 
                405                 410                 415     


Glu Ser Leu Trp Arg Asp Glu Asp Val Leu Thr Thr Phe Val Glu Ile 
            420                 425                 430         


Asn Ile Ala Gln Arg Asp Leu Glu Arg His Arg Pro Tyr Ser Leu Met 
        435                 440                 445             


Thr Phe Ala Asp Ala Arg Leu His Pro Arg Trp Ala Met Tyr Glu Ala 
    450                 455                 460                 


Leu Gly Gly Thr Asn Leu Arg Asn Tyr Glu Leu Thr Pro Glu Gly Lys 
465                 470                 475                 480 


Val Lys Ile Pro Leu Leu Ile Cys Glu Lys Asp Lys Leu Ser Glu Lys 
                485                 490                 495     


Thr Phe Thr Ile Pro Leu Ala Pro Ser Gly Gln Leu Lys Ser Leu Glu 
            500                 505                 510         


Ile Lys Ser Leu Pro Lys Lys Lys Val Lys Ile Ser Tyr Ala Ser Ala 
        515                 520                 525             


His Gln Phe Tyr Ala Gly Ile Pro Gly Gly Ser Glu Ile Leu Phe Asp 
    530                 535                 540                 


Arg Leu Phe Met Glu Asn Arg Ala Ser Ser Ala Leu Ala Asn Gly Ser 
545                 550                 555                 560 


Cys Gly Pro Ala Trp Leu Lys Leu Thr Val Asp Val Glu Ser Lys Ala 
                565                 570                 575     


Pro Pro Glu Trp Leu Asp Lys Lys Gly Arg Val Gln Thr Pro Pro Thr 
            580                 585                 590         


Val His His Phe Lys Thr Gly Leu Ala Asn Lys Ser Lys His Thr Asp 
        595                 600                 605             


Lys Leu Glu Pro Ser Leu Arg Val Leu Ser Val Asp Leu Gly Leu Arg 
    610                 615                 620                 


Thr Phe Ala Ser Cys Ser Val Phe Glu Leu Val Asp Glu Lys Pro Ala 
625                 630                 635                 640 


Lys Gly Leu Phe Phe Glu Thr Asp His Pro His Leu Trp Ala Lys His 
                645                 650                 655     


Glu Arg Ser Phe Lys Leu Thr Leu Pro Gly Glu Glu Ala Gly Asp Asp 
            660                 665                 670         


Pro Lys Val Ala Gln Ala Arg Arg Glu Ala Met Asp Glu Val Tyr Ser 
        675                 680                 685             


Leu Arg Arg Asp Met Tyr Arg Leu Lys Asp Ile Leu Arg Leu Lys Ile 
    690                 695                 700                 


Ile Ser Ala Pro Asn Glu Arg Arg Glu Lys Leu Glu Ser Lys Ile Ala 
705                 710                 715                 720 


Glu Met Arg Glu Lys Gln Asp Ala Arg Ala Val Val Thr Ser Asn Phe 
                725                 730                 735     


Phe Glu Arg Leu Ser Glu Lys Cys Asp Leu Asn Pro Pro Met Trp Glu 
            740                 745                 750         


His Ser Cys Asn Glu Ile His Arg Asp Ala Glu Lys Ala Phe Ser Ala 
        755                 760                 765             


Arg Ile Gly Glu Trp Arg Lys Arg Thr Arg Lys Arg Pro Gly Ser Trp 
    770                 775                 780                 


Glu Glu Trp Arg Glu Thr Arg Ser Tyr His Gly Gly Lys Ser Tyr Trp 
785                 790                 795                 800 


Met Ile Glu Tyr Leu Glu Ala Val Arg Lys Leu Leu Ile Gly Trp Ser 
                805                 810                 815     


Thr His Gly Arg Asp Tyr Gly Glu Ile Asn Arg Gln Asn Lys Lys Arg 
            820                 825                 830         


Tyr Gly Thr Val Ala Ser Lys Leu Leu Lys His Ile Asn Lys Leu Lys 
        835                 840                 845             


Glu Asp Arg Thr Lys Ala Gly Thr Asp Leu Ile Ile Gln Ala Ala Arg 
    850                 855                 860                 


Gly Tyr Ile Pro Leu Pro Gly Lys Gly Trp Met Glu Lys Tyr Arg Pro 
865                 870                 875                 880 


Cys Arg Val Ile Leu Phe Glu Asp Leu Ala Arg Tyr Arg Phe Lys Val 
                885                 890                 895     


Asp Arg Pro Arg Arg Glu Asn Ser Gln Leu Met Lys Trp Gly His Arg 
            900                 905                 910         


Glu Ile Ile Asn Glu Ala Thr Leu Gln Gly Glu Ile Tyr Gly Met Val 
        915                 920                 925             


Val Glu Thr Ala Gly Ala Gly Phe Ser Ser Arg Phe His Ala Lys Thr 
    930                 935                 940                 


Gly Ala Pro Gly Val Arg Cys Arg Tyr Leu Lys Glu Asp Asp Phe Glu 
945                 950                 955                 960 


Asn Gly Ala Pro Lys Glu Phe Leu Val Arg Gln Met Lys Asn Leu Met 
                965                 970                 975     


Lys Gly Asp Arg Leu Glu Pro Gly Leu Leu Val Pro Trp Asp Gly Gly 
            980                 985                 990         


Glu Leu Phe Ala Thr Val Asp Asn  Gly Lys Pro Ile Val  Ile His Ala 
        995                 1000                 1005             


Asp Ile  Asn Ala Ala Gln Asn  Leu Gln Arg Arg Phe  Trp Thr Arg 
    1010                 1015                 1020             


Phe Ala  Asp Ala Tyr Arg Val  Asn Ala Val Glu Glu  Asn Asp Asn 
    1025                 1030                 1035             


Trp Val  Val Thr Asp Thr Gly  Val Arg Val Leu Gly  Ala Leu Glu 
    1040                 1045                 1050             


Met Ala  Val His Gly Glu Ala  Asp Arg Lys Pro Arg  Thr Gly Phe 
    1055                 1060                 1065             


Thr Leu  His Gly Thr Leu Gln  Ser Gly Ala Glu Leu  Lys Ala Glu 
    1070                 1075                 1080             


Gly Lys  Lys Thr Asp Ile Lys  Asp Val Glu Glu Asp  Lys Asp Asp 
    1085                 1090                 1095             


Ser Ile  Ser Ser Glu Ile Ile  Glu Leu Gln Asp Glu  Lys Glu Arg 
    1100                 1105                 1110             


Lys Gly  Arg Glu Thr Phe Phe  Arg Asp Pro Ser Gly  Gly Ile Leu 
    1115                 1120                 1125             


Asp Pro  Gly Lys Trp Tyr Gly  Ser Lys Arg Phe Trp  Gly Arg Ala 
    1130                 1135                 1140             


Lys Gly  Ala Val Thr Glu Ala  Leu Leu Asp Asn Gln  Gly Ala Asn 
    1145                 1150                 1155             


Asn Ala  Leu Glu Glu Lys Pro  Gly Asn Asp Glu Leu  Pro Phe 
    1160                 1165                 1170         


<210> 39
<211> 1108
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12b sequence"

<400> 39
Met Ala Thr Arg Ser Phe Ile Leu Lys Ile Glu Pro Asn Glu Glu Val 
1               5                   10                  15      


Lys Lys Gly Leu Trp Lys Thr His Glu Val Leu Asn His Gly Ile Ala 
            20                  25                  30          


Tyr Tyr Met Asn Ile Leu Lys Leu Ile Arg Gln Glu Ala Ile Tyr Glu 
        35                  40                  45              


His His Glu Gln Asp Pro Lys Asn Pro Lys Lys Val Ser Lys Ala Glu 
    50                  55                  60                  


Ile Gln Ala Glu Leu Trp Asp Phe Val Leu Lys Met Gln Lys Cys Asn 
65                  70                  75                  80  


Ser Phe Thr His Glu Val Asp Lys Asp Glu Val Phe Asn Ile Leu Arg 
                85                  90                  95      


Glu Leu Tyr Glu Glu Leu Val Pro Ser Ser Val Glu Lys Lys Gly Glu 
            100                 105                 110         


Ala Asn Gln Leu Ser Asn Lys Phe Leu Tyr Pro Leu Val Asp Pro Asn 
        115                 120                 125             


Ser Gln Ser Gly Lys Gly Thr Ala Ser Ser Gly Arg Lys Pro Arg Trp 
    130                 135                 140                 


Tyr Asn Leu Lys Ile Ala Gly Asp Pro Ser Trp Glu Glu Glu Lys Lys 
145                 150                 155                 160 


Lys Trp Glu Glu Asp Lys Lys Lys Asp Pro Leu Ala Lys Ile Leu Gly 
                165                 170                 175     


Lys Leu Ala Glu Tyr Gly Leu Ile Pro Leu Phe Ile Pro Tyr Thr Asp 
            180                 185                 190         


Ser Asn Glu Pro Ile Val Lys Glu Ile Lys Trp Met Glu Lys Ser Arg 
        195                 200                 205             


Asn Gln Ser Val Arg Arg Leu Asp Lys Asp Met Phe Ile Gln Ala Leu 
    210                 215                 220                 


Glu Arg Phe Leu Ser Trp Glu Ser Trp Asn Leu Lys Val Lys Glu Glu 
225                 230                 235                 240 


Tyr Glu Lys Val Glu Lys Glu Tyr Lys Thr Leu Glu Glu Arg Ile Lys 
                245                 250                 255     


Glu Asp Ile Gln Ala Leu Lys Ala Leu Glu Gln Tyr Glu Lys Glu Arg 
            260                 265                 270         


Gln Glu Gln Leu Leu Arg Asp Thr Leu Asn Thr Asn Glu Tyr Arg Leu 
        275                 280                 285             


Ser Lys Arg Gly Leu Arg Gly Trp Arg Glu Ile Ile Gln Lys Trp Leu 
    290                 295                 300                 


Lys Met Asp Glu Asn Glu Pro Ser Glu Lys Tyr Leu Glu Val Phe Lys 
305                 310                 315                 320 


Asp Tyr Gln Arg Lys His Pro Arg Glu Ala Gly Asp Tyr Ser Val Tyr 
                325                 330                 335     


Glu Phe Leu Ser Lys Lys Glu Asn His Phe Ile Trp Arg Asn His Pro 
            340                 345                 350         


Glu Tyr Pro Tyr Leu Tyr Ala Thr Phe Cys Glu Ile Asp Lys Lys Lys 
        355                 360                 365             


Lys Asp Ala Lys Gln Gln Ala Thr Phe Thr Leu Ala Asp Pro Ile Asn 
    370                 375                 380                 


His Pro Leu Trp Val Arg Phe Glu Glu Arg Ser Gly Ser Asn Leu Asn 
385                 390                 395                 400 


Lys Tyr Arg Ile Leu Thr Glu Gln Leu His Thr Glu Lys Leu Lys Lys 
                405                 410                 415     


Lys Leu Thr Val Gln Leu Asp Arg Leu Ile Tyr Pro Thr Glu Ser Gly 
            420                 425                 430         


Gly Trp Glu Glu Lys Gly Lys Val Asp Ile Val Leu Leu Pro Ser Arg 
        435                 440                 445             


Gln Phe Tyr Asn Gln Ile Phe Leu Asp Ile Glu Glu Lys Gly Lys His 
    450                 455                 460                 


Ala Phe Thr Tyr Lys Asp Glu Ser Ile Lys Phe Pro Leu Lys Gly Thr 
465                 470                 475                 480 


Leu Gly Gly Ala Arg Val Gln Phe Asp Arg Asp His Leu Arg Arg Tyr 
                485                 490                 495     


Pro His Lys Val Glu Ser Gly Asn Val Gly Arg Ile Tyr Phe Asn Met 
            500                 505                 510         


Thr Val Asn Ile Glu Pro Thr Glu Ser Pro Val Ser Lys Ser Leu Lys 
        515                 520                 525             


Ile His Arg Asp Asp Phe Pro Lys Val Val Asn Phe Lys Pro Lys Glu 
    530                 535                 540                 


Leu Thr Glu Trp Ile Lys Asp Ser Lys Gly Lys Lys Leu Lys Ser Gly 
545                 550                 555                 560 


Ile Glu Ser Leu Glu Ile Gly Leu Arg Val Met Ser Ile Asp Leu Gly 
                565                 570                 575     


Gln Arg Gln Ala Ala Ala Ala Ser Ile Phe Glu Val Val Asp Gln Lys 
            580                 585                 590         


Pro Asp Ile Glu Gly Lys Leu Phe Phe Pro Ile Lys Gly Thr Glu Leu 
        595                 600                 605             


Tyr Ala Val His Arg Ala Ser Phe Asn Ile Lys Leu Pro Gly Glu Thr 
    610                 615                 620                 


Leu Val Lys Ser Arg Glu Val Leu Arg Lys Ala Arg Glu Asp Asn Leu 
625                 630                 635                 640 


Lys Leu Met Asn Gln Lys Leu Asn Phe Leu Arg Asn Val Leu His Phe 
                645                 650                 655     


Gln Gln Phe Glu Asp Ile Thr Glu Arg Glu Lys Arg Val Thr Lys Trp 
            660                 665                 670         


Ile Ser Arg Gln Glu Asn Ser Asp Val Pro Leu Val Tyr Gln Asp Glu 
        675                 680                 685             


Leu Ile Gln Ile Arg Glu Leu Met Tyr Lys Pro Tyr Lys Asp Trp Val 
    690                 695                 700                 


Ala Phe Leu Lys Gln Leu His Lys Arg Leu Glu Val Glu Ile Gly Lys 
705                 710                 715                 720 


Glu Val Lys His Trp Arg Lys Ser Leu Ser Asp Gly Arg Lys Gly Leu 
                725                 730                 735     


Tyr Gly Ile Ser Leu Lys Asn Ile Asp Glu Ile Asp Arg Thr Arg Lys 
            740                 745                 750         


Phe Leu Leu Arg Trp Ser Leu Arg Pro Thr Glu Pro Gly Glu Val Arg 
        755                 760                 765             


Arg Leu Glu Pro Gly Gln Arg Phe Ala Ile Asp Gln Leu Asn His Leu 
    770                 775                 780                 


Asn Ala Leu Lys Glu Asp Arg Leu Lys Lys Met Ala Asn Thr Ile Ile 
785                 790                 795                 800 


Met His Ala Leu Gly Tyr Cys Tyr Asp Val Arg Lys Lys Lys Trp Gln 
                805                 810                 815     


Ala Lys Asn Pro Ala Cys Gln Ile Ile Leu Phe Glu Asp Leu Ser Asn 
            820                 825                 830         


Tyr Asn Pro Tyr Glu Glu Arg Ser Arg Phe Glu Asn Ser Lys Leu Met 
        835                 840                 845             


Lys Trp Ser Arg Arg Glu Ile Pro Arg Gln Val Ala Leu Gln Gly Glu 
    850                 855                 860                 


Ile Tyr Gly Leu Gln Val Gly Glu Val Gly Ala Gln Phe Ser Ser Arg 
865                 870                 875                 880 


Phe His Ala Lys Thr Gly Ser Pro Gly Ile Arg Cys Ser Val Val Thr 
                885                 890                 895     


Lys Glu Lys Leu Gln Asp Asn Arg Phe Phe Lys Asn Leu Gln Arg Glu 
            900                 905                 910         


Gly Arg Leu Thr Leu Asp Lys Ile Ala Val Leu Lys Glu Gly Asp Leu 
        915                 920                 925             


Tyr Pro Asp Lys Gly Gly Glu Lys Phe Ile Ser Leu Ser Lys Asp Arg 
    930                 935                 940                 


Lys Cys Val Thr Thr His Ala Asp Ile Asn Ala Ala Gln Asn Leu Gln 
945                 950                 955                 960 


Lys Arg Phe Trp Thr Arg Thr His Gly Phe Tyr Lys Val Tyr Cys Lys 
                965                 970                 975     


Ala Tyr Gln Val Asp Gly Gln Thr Val Tyr Ile Pro Glu Ser Lys Asp 
            980                 985                 990         


Gln Lys Gln Lys Ile Ile Glu Glu  Phe Gly Glu Gly Tyr  Phe Ile Leu 
        995                 1000                 1005             


Lys Asp  Gly Val Tyr Glu Trp  Val Asn Ala Gly Lys  Leu Lys Ile 
    1010                 1015                 1020             


Lys Lys  Gly Ser Ser Lys Gln  Ser Ser Ser Glu Leu  Val Asp Ser 
    1025                 1030                 1035             


Asp Ile  Leu Lys Asp Ser Phe  Asp Leu Ala Ser Glu  Leu Lys Gly 
    1040                 1045                 1050             


Glu Lys  Leu Met Leu Tyr Arg  Asp Pro Ser Gly Asn  Val Phe Pro 
    1055                 1060                 1065             


Ser Asp  Lys Trp Met Ala Ala  Gly Val Phe Phe Gly  Lys Leu Glu 
    1070                 1075                 1080             


Arg Ile  Leu Ile Ser Lys Leu  Thr Asn Gln Tyr Ser  Ile Ser Thr 
    1085                 1090                 1095             


Ile Glu  Asp Asp Ser Ser Lys  Gln Ser Met 
    1100                 1105             


<210> 40
<211> 1450
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12b sequence"

<400> 40
Met Tyr Arg Gly Phe Cys Thr Val Thr Ala Thr Ser Gly Gly Trp Gln 
1               5                   10                  15      


Ser Thr Thr Phe Leu Ala Gly Ala Gln Met Ala Asp Thr Thr Thr Arg 
            20                  25                  30          


Ala Tyr Thr Leu Lys Leu Gln Gly Asp Arg Leu Ala Leu Trp Arg Asn 
        35                  40                  45              


His Val Ile Phe Asn Asn Gly Val Lys Ala Trp Gly Glu Trp Leu Leu 
    50                  55                  60                  


Cys Leu Arg Gly Gly Leu Pro Ala Ser Leu Ala Asp His Arg Asp Ser 
65                  70                  75                  80  


Leu Asp Val Ser Lys Gly Glu Ile Ser Arg Thr Phe Lys Glu Arg Thr 
                85                  90                  95      


Ala Ala Ile Thr Pro Ala Thr Ile Arg Gln Glu Leu Lys Phe Lys Ala 
            100                 105                 110         


Ala Thr Glu Lys Lys Val Arg Glu Glu Val Ala Ser Arg Arg Lys Lys 
        115                 120                 125             


Val Thr Glu Thr Ala Val Ala Lys Glu Leu Leu Ala Ala Arg Arg Ser 
    130                 135                 140                 


Glu Leu Arg Arg Ile Leu Ala Leu Ser Trp Leu Cys Pro Glu Thr Pro 
145                 150                 155                 160 


Val Gln Leu Val Pro Gln Ala Ala Ile Val Ala Ala Ala Asp Asp Ser 
                165                 170                 175     


Asp Arg Glu Gln Lys Val Leu Asp Gly Phe Arg Gln Ile Leu Lys Arg 
            180                 185                 190         


Lys Gly Val Ser Asp Val Ala Gly Trp Val Gln Asp Cys Asp Ala Thr 
        195                 200                 205             


Leu Arg Ala Thr Ile Arg Ser Asp Ala Val Trp Val Asp Arg Thr Ala 
    210                 215                 220                 


Cys Phe Cys Ser Met Pro Arg Ala Val Arg Pro Ser Glu Val Asp Ala 
225                 230                 235                 240 


Ala Lys His Leu Phe Arg Leu Phe Gly Ser Met Ser Asp Tyr Phe Ala 
                245                 250                 255     


Thr Ala Ser Ala Ser Ser Gly Pro Ala Glu Pro Lys Asp Phe Ala Asn 
            260                 265                 270         


Thr Cys Arg Asp Trp Val Ser Ser Phe Trp Gly Gly Gly Glu Lys Ser 
        275                 280                 285             


Asn Lys Ala Ser Ile Leu Ala Ala Leu Ser Ala Ile Ala Gln Ile Lys 
    290                 295                 300                 


Pro Thr Arg Val Val Gly Lys Arg Gly Pro Ala Ala Leu Ala Val Ile 
305                 310                 315                 320 


Ala Gly Val Leu Glu Gln Lys Pro Val Asp Asp Ser Val Glu Ala Leu 
                325                 330                 335     


Ala Arg Ala Ile Gly Trp Leu Ser Gly Arg Pro Ser Ala Ala Arg Leu 
            340                 345                 350         


Ala Ile Asn Ala Ile Ala Ala Ser Pro Arg Val Ser Gln Lys Leu Trp 
        355                 360                 365             


Asp Arg Leu Val Leu Ala Cys Glu Lys Asp Cys Gly Arg Gln Lys Ser 
    370                 375                 380                 


Lys Leu Ala Phe Glu Gly Ser Ala Ser Thr Ile Ala Ser Ala Leu Glu 
385                 390                 395                 400 


Pro Arg Leu Ala Gly Leu Thr Gly Met Pro Tyr Ala Ser Thr Gly Arg 
                405                 410                 415     


Glu Leu Ile Gly Glu Tyr Ala Thr Met Leu Ala Phe Ala Met Arg Arg 
            420                 425                 430         


Val Ser Gln Ile His Thr Lys Ala Lys Gln Ala Glu Ala Glu Arg Arg 
        435                 440                 445             


Ser Phe Ala Pro Glu Gln Ala Arg Leu Ala Leu Val Pro Ser Ala Ala 
    450                 455                 460                 


Arg Lys Trp Leu Glu Asp Tyr Val Glu Ala Arg Thr Ala Ala Ser Gly 
465                 470                 475                 480 


Ala Val Asp Gly Tyr Gln Leu Arg Lys Arg Ala Leu Gly Gly Trp Ala 
                485                 490                 495     


Asp Val Val Ala Ala Trp Ser Arg Cys Glu Thr Ser Glu Asp Arg Ile 
            500                 505                 510         


Ala Ala Val Arg Glu Leu Gln Ala Asp Trp Glu Lys Ala Gly Asp Val 
        515                 520                 525             


Gln Leu Phe Glu Ala Leu Ala Ala Asp Asp Ala Ile Cys Val Trp Gln 
    530                 535                 540                 


Ser Ala Asn Gly Lys Thr Ala Ala Ser Ile Leu Thr Asp Tyr Val Arg 
545                 550                 555                 560 


Ala Ala Val Ala Asp Gln Asn Ala Thr Arg Phe Lys Val Pro Ala Tyr 
                565                 570                 575     


Arg His Pro Asp Pro Leu Arg Ser Pro Thr Phe Val Gly Phe Gly Asn 
            580                 585                 590         


Ser Gln Trp Ser Ile Ala Tyr Ser Ala Gln Gly Glu Ala Arg Glu Arg 
        595                 600                 605             


Arg Lys Leu Leu Asp Arg Ala Ser Gly Ser Ala Lys Asp Ala Glu Arg 
    610                 615                 620                 


Ala Arg Glu Gly Leu Ala Arg Glu Ala Val Leu Gln Asn Val Ser Leu 
625                 630                 635                 640 


Asp Leu Trp Ala Gly Asp Lys Met Val Pro Thr Gln Phe Arg Trp Gln 
                645                 650                 655     


Ser Arg Arg Leu Leu Ser Asp Leu Ala Leu His Ser Val Pro Ala Met 
            660                 665                 670         


Lys Gly Ala Lys Val Thr Arg Ala Thr Arg Phe Gly Arg Ala Arg Ile 
        675                 680                 685             


Ala Ala Gly Pro Val Leu Leu Asp Gly Ile Ala Asp Asp Thr Pro Trp 
    690                 695                 700                 


Asn Gly Arg Leu Gln Ala Pro Arg Arg Gln Leu Glu Asp Leu Ala Arg 
705                 710                 715                 720 


Ile Leu Asp Ala Lys Gly Leu Pro Phe Asp Asp Glu Ser Lys Trp Pro 
                725                 730                 735     


Pro Lys Val Arg Ser Arg Leu Lys His Leu Gly Trp Phe Leu Thr His 
            740                 745                 750         


Ser Ala Lys Leu Thr Pro Ser Gly Pro Trp Leu Asp Tyr Val Ala Gly 
        755                 760                 765             


Gly Leu Ala Asn Gly Trp Lys Trp Ala Glu Gly Arg Glu Gly Ala Cys 
    770                 775                 780                 


Leu Phe Arg Glu Asp Asn Lys Asp Arg Lys Gly Arg Ala Lys Leu Ile 
785                 790                 795                 800 


Leu Ser Arg Leu Pro Gly Leu Arg Leu Leu Ser Val Asp Leu Gly Leu 
                805                 810                 815     


Arg Thr Ser Ala Ala Ala Ala Val Trp Gln Val Val Ser Lys Arg Gln 
            820                 825                 830         


Leu Thr Ala Ala Lys Asp Gly Ala Lys Ser Val Ser Asp Thr Asp Leu 
        835                 840                 845             


Phe Cys Leu Val Arg Thr Gly Asp Arg Thr Gln Val Tyr Arg Arg Ile 
    850                 855                 860                 


Gly Leu Ser Ala Trp Ala Arg Leu Glu Arg Gln Phe Leu Ile Arg Leu 
865                 870                 875                 880 


Asp Gly Glu Lys Ala Ala Ala Arg Pro Ala Thr Thr Asn Glu Trp Glu 
                885                 890                 895     


Ser Leu Gln Ser Phe Arg Ala Trp Leu Gly Cys Gly Ile Glu Arg Arg 
            900                 905                 910         


Pro Glu Lys Leu Pro Pro Val Asp Ser Leu Gln Gln Ser Ala Glu Arg 
        915                 920                 925             


Leu Cys Arg Leu Gly Leu Arg Arg Leu Ser Asp Leu Ala Arg Val Ala 
    930                 935                 940                 


Tyr Leu Leu Thr Ala Lys Glu Arg Pro Ile Met Gly Gly Arg Thr Ala 
945                 950                 955                 960 


Pro Leu Asp Glu Glu Gly Thr Val Gln Ala Ala Gln Asp Ala Leu Ser 
                965                 970                 975     


Ile Leu His Ala Leu Gly Ser Ser Glu Asp Phe Ser Asp Ala Arg Leu 
            980                 985                 990         


Gln Gly Ile Trp Arg Thr Ala Ile  Gly Asp Thr Pro Pro  Leu Ala Ala 
        995                 1000                 1005             


Arg Leu  Thr Lys Lys Gln Arg  Gln Glu Leu Arg Glu  Ala Leu Arg 
    1010                 1015                 1020             


Pro Ala  Ala Glu Lys Leu Arg  Gly Lys Ala Ala Leu  Gly Lys Glu 
    1025                 1030                 1035             


Leu Ala  Asp Leu Trp Lys Glu  Arg Ser Ala Ala Trp  Ala Lys His 
    1040                 1045                 1050             


Leu Arg  Trp Leu Arg Asp Trp  Val Ile Pro Arg Phe  Asp Lys Arg 
    1055                 1060                 1065             


Lys Asn  Gly Glu Arg Val Arg  Ser Ala Arg Gly Val  Gly Gly Leu 
    1070                 1075                 1080             


Ser Leu  Asp Arg Ile Ala Thr  Ile Arg Gly Val Tyr  Gln Ile Met 
    1085                 1090                 1095             


Arg Ala  Tyr Ala Ser Arg Ala  Glu Pro Thr Asn Leu  Arg Ala Gly 
    1100                 1105                 1110             


Val Glu  Arg Leu Glu Lys Ala  Ala Ala Lys Lys Leu  Arg Pro Glu 
    1115                 1120                 1125             


Phe Gly  Arg Arg Met Leu Ala  Lys Met Glu Arg Leu  Arg Glu Asn 
    1130                 1135                 1140             


Arg Val  Lys Gln Ile Ala Ser  Arg Ile Val Glu Ala  Ala Leu Gly 
    1145                 1150                 1155             


Val Gly  Ser Glu Asp Arg Leu  His Trp Glu Arg Gly  Arg Arg Arg 
    1160                 1165                 1170             


Pro Thr  Ala Ala Ile Ser Asp  Pro Arg Phe Ala Pro  Cys His Ala 
    1175                 1180                 1185             


Val Val  Ile Glu Asn Leu Glu  Asn Tyr Arg Pro Asp  Glu Lys Arg 
    1190                 1195                 1200             


Thr Arg  Arg Glu Asn Arg Gly  Leu Met Ser Trp Ala  Ala Arg Ala 
    1205                 1210                 1215             


Val Gly  Lys Tyr Leu Ala Glu  Gly Cys Gln Leu His  Gly Leu Tyr 
    1220                 1225                 1230             


Leu Arg  Gln Val Ser Pro Ala  Tyr Thr Ser Arg Gln  Asp Ser Arg 
    1235                 1240                 1245             


Thr Gly  Cys Pro Gly Leu Arg  Cys Asn Asp Val Arg  Ala Gln Glu 
    1250                 1255                 1260             


Leu Leu  Asn Pro Glu Gly Trp  Ile Gly Arg Leu Val  Ala Arg Ala 
    1265                 1270                 1275             


Ala Glu  Ala Val Lys Glu Gly  Lys Ala Thr Pro Arg  Gln Arg Leu 
    1280                 1285                 1290             


Leu Val  Thr Leu Ala Glu Ser  Ala Arg Ala Gly Ile  Ala Glu Ser 
    1295                 1300                 1305             


Ala Ala  Val Arg Ile Ile Ala  Pro Gly Gly Gln Leu  Phe Ile Ala 
    1310                 1315                 1320             


Ala Asp  Pro Gln Ser Pro Ala  Ser Asn Gly Ile His  Ala Asp Met 
    1325                 1330                 1335             


Asn Ala  Ala Ala Asn Ile Gly  Leu Val Ala Leu Leu  Asp Pro Asp 
    1340                 1345                 1350             


Trp Pro  Ala Ala Trp Trp Arg  Leu Pro Cys Lys Ala  Ala Thr Gly 
    1355                 1360                 1365             


Tyr Val  Asp Glu Ser Lys Val  Gly Gly Ser Glu Ala  Val Pro Leu 
    1370                 1375                 1380             


Gly Arg  Ala Ile Leu Glu Val  Gly Ala Glu Ala Gly  Lys Val Tyr 
    1385                 1390                 1395             


Val Asn  Ala Trp Ser Asp Pro  Gln Asp Ser Ala Val  Ser Arg Arg 
    1400                 1405                 1410             


Glu Trp  Thr Asp Thr Lys Arg  Tyr Trp Arg Asp Val  Glu Glu Arg 
    1415                 1420                 1425             


Val Val  Glu Ile Leu Leu Ala  Ser Asn Arg Gly Gly  Arg Arg Gly 
    1430                 1435                 1440             


Lys Pro  Gly Ala Val Pro Phe  
    1445                 1450 


<210> 41
<211> 792
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12b sequence"

<400> 41
Met Ala Thr Lys Ser Phe Glu Ala Lys Ile Val Cys Lys Pro Asp Glu 
1               5                   10                  15      


Lys Tyr Thr Ala Glu Gln Lys Lys Gln Phe Leu Trp Phe Thr His Gln 
            20                  25                  30          


Val Phe Asn Asp Gly Val Arg Lys Val Ile Pro Tyr Val Phe Lys Met 
        35                  40                  45              


Lys Arg Gly Glu Leu Gly Pro Glu Phe Gln Ala Ile Tyr Tyr Ala Ile 
    50                  55                  60                  


Thr Ser Ser Gln Asp Ala Ile Gly Lys Leu Glu Ala Val Ile Asn Pro 
65                  70                  75                  80  


Asp Trp Thr Ser Gly Lys Ile Gly Lys Ser Asp Pro Asn Lys Trp Lys 
                85                  90                  95      


Glu Leu Leu Lys Tyr Gln Glu Leu Glu Lys Gly Phe Arg Gln Arg Leu 
            100                 105                 110         


Lys Glu Glu Gly Ile Lys Ser Thr Lys Lys Phe Arg Lys Glu Leu Glu 
        115                 120                 125             


Asp Glu Lys Lys Lys Leu Ala Lys Glu Ile Gly Gln Lys Asp Ile Trp 
    130                 135                 140                 


Ala Asp Ala Ala Ala Ile Leu Arg Asn Lys Asn Leu Leu Leu Phe Asn 
145                 150                 155                 160 


Arg Asp Glu Leu Leu Pro Asn Leu Pro Ser Glu Phe Arg Arg Lys Ile 
                165                 170                 175     


Tyr Glu Met Thr Ile Gln Leu Ile His Gly His Gln Glu Leu Val Ala 
            180                 185                 190         


Asn Trp Glu Asp Glu His Ala Glu Trp Leu Ile Glu Lys Asp Lys Trp 
        195                 200                 205             


Glu Glu Glu His Pro Glu Tyr Met Asn Val Arg Pro Ile Phe Glu Lys 
    210                 215                 220                 


Phe Glu Lys Glu Gln Gly Lys Val Lys Gly Ser Arg Ile Arg Trp Leu 
225                 230                 235                 240 


Ala Tyr Leu Asp Phe Leu Ser Ser Lys Pro Glu Leu Ala Asn Trp Arg 
                245                 250                 255     


Gly Lys Ala Lys Glu Thr Ile Pro Leu Thr Lys Glu Glu Arg Ala Gly 
            260                 265                 270         


Phe Arg Lys Pro Gly Gln His Phe Ala Ala Phe Phe Asn Lys Asn Pro 
        275                 280                 285             


Glu Leu Gln Glu Leu Asp Arg Leu His Lys Glu Tyr Gln Glu Lys Phe 
    290                 295                 300                 


Ala Arg Thr Gln Ser Lys Arg Thr Pro His Pro Asp Gly Phe Lys His 
305                 310                 315                 320 


Arg Pro Thr Phe Thr Leu Pro Asp Ala Met Arg His Pro Val Trp Tyr 
                325                 330                 335     


Ser Phe Lys Gly Ala Thr Asp Pro Thr Lys Gly Ser Thr Tyr Arg Asn 
            340                 345                 350         


Leu Asp Leu Glu Asn Cys Thr Leu Asp Leu Lys Val Leu Thr Ala Met 
        355                 360                 365             


Glu Gly Glu Gly Arg Asn Pro Gly Gly Met Ile Gln Tyr Ala Phe Glu 
    370                 375                 380                 


Pro Asp Glu Arg Ile Lys Gly Phe Arg Tyr Val Gly Thr Thr Glu Lys 
385                 390                 395                 400 


Gly Lys Arg Ala Lys Gly Tyr Ile Tyr Tyr Asp Pro Ile Leu Glu Lys 
                405                 410                 415     


Glu Arg Pro Ala Lys Ile Gln Gly Ile Lys Leu Val Phe Arg Pro Pro 
            420                 425                 430         


Arg Pro Asp Gly Thr Ala Tyr Leu Ile Phe Ser Cys Gln Ile Glu Asp 
        435                 440                 445             


Glu Lys Pro Lys Ile Lys Ile Trp Lys Asp Lys Glu Glu Glu Ser Pro 
    450                 455                 460                 


Gly Glu Ile Thr Lys Arg Lys Lys Thr Glu Val Tyr Pro Pro Glu Leu 
465                 470                 475                 480 


Ile Thr Leu Ala Ile Asp Phe Gly Gln Arg His Leu Gly Ala Ile Thr 
                485                 490                 495     


Ile Cys Lys Asn Asn Asn Gly Arg Pro Glu Pro Ile Arg Phe Ile Pro 
            500                 505                 510         


Ala Tyr Pro Lys Arg Arg Lys Asp Arg Glu Ser Lys Pro Val Ser Ala 
        515                 520                 525             


Trp Leu Ala Lys Ile Pro Gly Leu Thr Phe Asn Ala Val Gly Met His 
    530                 535                 540                 


Glu Lys Glu Ile Ser Ala Gly Met Ser Arg Arg Phe Gln Asp Pro Lys 
545                 550                 555                 560 


Ser Ile Arg Gln Ala Gly Glu Lys Glu Gly Arg Lys Ser Lys Gly Gln 
                565                 570                 575     


His Ile Pro Glu Thr Glu Thr Pro Trp Ala His Leu Arg Glu His Ile 
            580                 585                 590         


Ala Asn Met Lys Glu Asp His Tyr Lys Lys Ala Ala Asn Leu Ile Ile 
        595                 600                 605             


Arg Thr Ala Leu Gln Asn Gly Ala Gln Val Ile Leu Ile Glu Asn Leu 
    610                 615                 620                 


Arg Asn Tyr Arg Pro Met Leu Glu Arg Thr Asn Leu Glu Asn Arg Arg 
625                 630                 635                 640 


Arg Met Gln Trp Ala Val Arg Gln Thr Ala Lys Phe Leu Glu Asp Thr 
                645                 650                 655     


Ala Arg Pro Leu Gly Leu Ile Val Arg Gln Val Ser Ser Ala Tyr Thr 
            660                 665                 670         


Ser Arg Phe Cys Ser Ser Cys Gly His Pro Gly Ala Arg Val Ser Leu 
        675                 680                 685             


Pro Gly Gln Lys Asn Trp Glu Lys Phe Tyr Ala Glu Lys Tyr Gly Lys 
    690                 695                 700                 


Glu Arg Lys Met Ile Ala Val Ala Gly Gly Gln Phe Phe Cys Cys Pro 
705                 710                 715                 720 


Ala Cys Lys Lys Ile Ile Asn Ala Asp Ile Asn Ala Ser Leu Asn Met 
                725                 730                 735     


His Lys Val Phe Tyr Gln Asn Phe Ile Trp Pro Gly Lys Ile Asp Lys 
            740                 745                 750         


Lys Asp Thr Lys Asn Phe Ile Trp Gln Gly Lys Asn Tyr Asn Trp Asp 
        755                 760                 765             


Gln Ile Ala Asp Asp Val Gln Ser Phe Leu Asp Gln Lys Ala Gly Ile 
    770                 775                 780                 


Lys Lys Glu Asp Asp Ile Pro Tyr 
785                 790         


<210> 42
<211> 1382
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12b sequence"

<400> 42
Met Ala Tyr Gly Ser Glu Ala Pro Asp Glu Arg Asn Arg Lys Val Thr 
1               5                   10                  15      


Glu Arg Phe Arg Ile Ile Leu Ser Arg Met Gly Ile Asn Gln Gln Gln 
            20                  25                  30          


Glu Gln Glu Trp Leu Asp Ala Cys Arg Pro Ala Leu Thr Ala Ser Ile 
        35                  40                  45              


Arg Glu Asp Ala Val Trp Ile Asp Arg Ser Ala Cys Phe Ala Glu Ala 
    50                  55                  60                  


Gln Gln His Tyr Pro Gly Leu Ser Ser Glu Trp Ala Arg Glu Thr Leu 
65                  70                  75                  80  


Phe Asp Phe Leu Gly Gly Glu Asn Asp Tyr Phe Ala Leu Pro Asp Pro 
                85                  90                  95      


Glu Ala Ala Pro Ser Ser Glu Ala Lys Asp Phe Val Gln Lys Ala Gly 
            100                 105                 110         


Gly Trp Leu Ser Arg His Trp Gly Ala Gly Lys Lys Ser Asp Ser Thr 
        115                 120                 125             


Ala Ile Ser Thr Asn Leu Asn Arg Leu Ala Gly Val Glu Ser Lys Ala 
    130                 135                 140                 


Ile Val Gly Arg Cys Gly Cys Asp Ala Leu Ala Val Leu Leu Thr Thr 
145                 150                 155                 160 


Leu Gly Gly Trp Pro Ala Lys Asn Ala Asp Ser Gly Thr Leu Tyr His 
                165                 170                 175     


Gln Leu Lys Gln Ala Val Gly Trp Lys Gly Arg Pro Ser Arg Ala Ala 
            180                 185                 190         


Lys Ala Leu Glu Lys Val Arg Asp Ala Pro Glu Val Thr Asp Ala Leu 
        195                 200                 205             


Trp Arg Gln Thr Ala Asp Thr Leu Arg Gln Glu Ala Val Ala Gln Ser 
    210                 215                 220                 


Ser Arg Ala Ala Gly Gly Ser Gly Val Pro Ala Trp Met Pro Ala Trp 
225                 230                 235                 240 


Arg Glu Asp Met Glu Ala Arg Leu Gly Met Pro Tyr Arg Gly Ala Arg 
                245                 250                 255     


Asp Tyr Ile Trp Glu His Ser Val Met Leu Asp His Ala Leu Arg Arg 
            260                 265                 270         


Val Ser Ser Ala His Thr Trp Ile Lys Arg Ala Glu Ala Lys Arg Arg 
        275                 280                 285             


Arg Phe Gln Gln Asp Ala Asp Lys Ile Gly Ser Ile Pro Ala Lys Ala 
    290                 295                 300                 


Arg Glu Trp Leu Asp Ala Phe Arg Glu Arg Arg Phe Ser Ala Ser Gly 
305                 310                 315                 320 


Ala Leu Arg Gly Tyr Leu Ile Arg Glu Arg Ala Ile Asp Gly Trp Asp 
                325                 330                 335     


Arg Val Val Gln Ala Trp Ala Ser Leu Gly Pro Asn Cys Thr Arg Glu 
            340                 345                 350         


Gln Arg Ile Ala Ala Ala Arg Asp Val Gln Ala Asn Leu Asp Glu Asp 
        355                 360                 365             


Glu Lys Phe Gly Asp Ile Gln Leu Phe Ala Gly Val Gly Asp Glu Asp 
    370                 375                 380                 


Glu Gly Asp Pro Gln Pro Cys Leu Ala Asp Asp Asp Ala Ile Cys Val 
385                 390                 395                 400 


Trp Arg Asp Leu Asn Gly Arg Ala Asp Ser Asn Ile Leu Lys Asp Tyr 
                405                 410                 415     


Val Ala Ala Thr Val Ala Lys His Asp Gln Gln Arg Phe Lys Val Pro 
            420                 425                 430         


Ala Tyr Arg His Pro Asp Pro Leu Arg His Pro Val Tyr Val Asp Tyr 
        435                 440                 445             


Gly Asn Ser Arg Trp Ser Ile Glu Tyr Ser Ala Leu Lys Ala Ala His 
    450                 455                 460                 


Gln Arg Arg Lys Thr Thr Glu Lys Leu Val Gln Ala Lys Thr Asp Arg 
465                 470                 475                 480 


Ala Arg Ala Lys Phe Gln Gln Lys Pro Ala Asp Thr Pro Asp Leu Arg 
                485                 490                 495     


Gly Val Thr Leu Gly Val Trp Thr Gly Ser Ser Ile Glu Lys Val Ser 
            500                 505                 510         


Leu His Trp His Gly Lys Arg Phe Trp Lys Asp Leu Asp Leu Asp His 
        515                 520                 525             


Phe Gly Arg Asp Pro Ser Ala Thr Val Ser Arg Ala Asp Arg Leu Gly 
    530                 535                 540                 


Arg Val Ala Ala Ser Gln His Pro Glu Ala Ala Val His Val Ala Lys 
545                 550                 555                 560 


Val Phe Glu Gln Gln Asp Trp Asn Gly Arg Leu Gln Val Pro Arg His 
                565                 570                 575     


Glu Leu Gln Arg Leu Ala Asp Leu Val Tyr Gly Lys Gly Gly Asp Pro 
            580                 585                 590         


Asp Phe Ala Lys Leu Gly Ser Leu Asp Glu Arg Arg Thr Arg Arg Gln 
        595                 600                 605             


Trp Glu His Leu Ser Trp Phe Leu Thr Thr Ser Thr Thr Ile Gln Pro 
    610                 615                 620                 


Arg Gly Pro Trp Leu Asp Tyr Val Ala Gln Gly Leu Pro Gln Gly Ile 
625                 630                 635                 640 


Gln Tyr Lys Lys Gly Arg Asn Gly Tyr Tyr Leu Glu Tyr Ala Ala Asn 
                645                 650                 655     


Gln Gly Arg Lys Arg Arg Ala Arg Leu Cys Leu Ala Arg Leu Pro Gly 
            660                 665                 670         


Leu Arg Val Leu Ser Leu Asp Leu Gly Asp Arg Tyr Ala Ala Ala Cys 
        675                 680                 685             


Ala Val Trp Glu Thr Leu Thr Arg Glu Gln Ile Thr Gln Glu Cys His 
    690                 695                 700                 


Gln Ala Gly His Pro Gly Pro Ser Gln Asp Asp Leu Phe Ile His Leu 
705                 710                 715                 720 


Arg His Arg Thr Gly Lys Pro Gln Lys Ser Gly Arg Asn Lys Gly Lys 
                725                 730                 735     


Pro Val Thr Lys Thr Thr Ile Tyr Arg Arg Ile Gly Pro Asp Leu Leu 
            740                 745                 750         


Pro Asp Gly Thr Pro His Pro Ala Pro Trp Ala Arg Leu Gln Arg Gln 
        755                 760                 765             


Phe Leu Ile Arg Leu Gln Gly Glu Asp Arg Pro Ala Arg Phe Ala Ser 
    770                 775                 780                 


Gln His Glu Ile Asp Gly Ser Asn Arg Phe Arg Glu Phe Leu Gly Leu 
785                 790                 795                 800 


Pro Pro Leu Ala Asp Arg Pro Arg Val Asp Asp Leu His Arg Asp Met 
                805                 810                 815     


Val Arg Leu Ala Arg Leu Gly Leu Arg Arg Leu Ala Asp Ala Ala Arg 
            820                 825                 830         


Ile Ala Phe Ala Met Thr Ala Thr Lys Lys Pro Ile Ser Gly Gly Arg 
        835                 840                 845             


Glu Glu Thr Leu Ala Thr Glu Gln Arg Ile Glu Phe Leu Gln Asp Ala 
    850                 855                 860                 


Leu Val Arg Trp Gln Ala Leu Ala Ala Ser Ser Arg Tyr Arg Asp Asp 
865                 870                 875                 880 


Trp Ala Arg Gln Ala Trp Gln Glu Trp Ile Val Glu Lys Leu Gly Gly 
                885                 890                 895     


Pro Gln Pro Ala Glu Ile Ala Asp Glu Leu Pro Arg Ser Gln Gln Ala 
            900                 905                 910         


Thr Arg Val Glu Thr Ala Arg Arg Ser Leu Arg Glu Val Ala Ala Lys 
        915                 920                 925             


Leu Ser Asn Pro Gln Ser Ser Ser Ala Thr Glu Leu His Gly Leu Trp 
    930                 935                 940                 


Ala Ala Arg Trp Gln Glu Arg Gln Thr Lys Trp Arg Gln Tyr Leu Arg 
945                 950                 955                 960 


Trp Leu Arg Arg Leu Ile Leu Pro Arg Arg Lys Asp Tyr Gln Gln Ala 
                965                 970                 975     


Asn Arg Gln Val His Arg Val Gly Gly Leu Ser Val Lys Arg Leu Gln 
            980                 985                 990         


Thr Ile Arg Gln Leu Tyr Gln Val  Leu Lys Ala Phe Arg  Met Arg Pro 
        995                 1000                 1005             


Glu Pro  Ser Asp Leu Arg Lys  Asn Ile Pro Ala Pro  Gly Asp Pro 
    1010                 1015                 1020             


Ser Leu  Ala Ser Phe Gly Arg  Arg Ile Leu His His  Arg Glu Arg 
    1025                 1030                 1035             


Leu Arg  Gln Gln Arg Ile Lys  Gln Leu Ala Ser Arg  Leu Val Glu 
    1040                 1045                 1050             


Ala Ala  Leu Gly Ala Gly Arg  Ile Ser Lys Arg Leu  Gly Arg Asp 
    1055                 1060                 1065             


Arg Arg  Arg Pro Arg Gln Ser  Val Asp Ala Pro Cys  His Ala Val 
    1070                 1075                 1080             


Val Ile  Glu Asn Leu Glu Arg  Tyr Lys Pro Glu Asp  Ser Arg Leu 
    1085                 1090                 1095             


Arg Arg  Glu Asn Arg Gln Leu  Met Asn Trp Gln Ala  Arg Asn Leu 
    1100                 1105                 1110             


Arg Lys  Tyr Ile Val Glu Gly  Cys Glu Leu His Gly  Leu Leu Phe 
    1115                 1120                 1125             


Val Glu  Val Trp Pro Ala Tyr  Thr Ser Arg Gln Asp  Thr Arg Thr 
    1130                 1135                 1140             


Gly Ala  Pro Gly Val Arg Cys  Glu Asp Val Pro Arg  Ser Val Leu 
    1145                 1150                 1155             


Glu Glu  Ala Thr Arg Arg Ile  Arg Ala Leu Gly Ser  Ala Pro Ser 
    1160                 1165                 1170             


Gly Ser  Ser Arg Gly Arg Ser  Glu Thr Arg Phe Glu  Arg Glu Val 
    1175                 1180                 1185             


Cys Arg  Trp Ile His Glu Phe  Asn Arg Val Val Gly  Ser Ser Ser 
    1190                 1195                 1200             


Gly Leu  Ser Pro Arg Gln Ser  Val Leu Lys Ala Phe  Leu Asp His 
    1205                 1210                 1215             


Gln Ala  Ala Ile Pro Thr Trp  Arg Ser Thr Val Arg  Leu Pro Arg 
    1220                 1225                 1230             


Arg Gly  Gly Glu Leu Phe Val  Ser Ala Asp Ala Asn  Ser Pro Leu 
    1235                 1240                 1245             


Ala Asn  Gly Leu Gln Ala Asp  Leu Asn Ala Ala Ala  Asn Ile Gly 
    1250                 1255                 1260             


Leu Lys  Ala Leu Thr Asp Pro  Asp Trp Met Gly Ala  Trp Trp Phe 
    1265                 1270                 1275             


Val Leu  Val Lys Arg Asp Ser  Gly Gln Pro Val Pro  Gln Gln Val 
    1280                 1285                 1290             


Gln Gly  Ser Pro Ile Trp Glu  Ser Cys Thr Arg Leu  Ser Ser Pro 
    1295                 1300                 1305             


Ala Thr  Val Asp Ser Ser Asp  Ser Pro Ala Gly Ala  Arg Arg Ser 
    1310                 1315                 1320             


Lys Gly  Arg Gly Ala Arg Gly  Arg Ala Arg Ala Thr  Glu Tyr Arg 
    1325                 1330                 1335             


Trp Ser  Pro Leu Ser Ala Met  Thr Met Pro Asp Asn  Lys Thr Trp 
    1340                 1345                 1350             


Trp Pro  Thr Arg Asp Tyr Trp  Pro Glu Ile Glu Arg  Gln Ile Ala 
    1355                 1360                 1365             


Asp Arg  Leu Leu Arg Glu Gln  Ile Asp Pro Glu Asn  Arg Phe 
    1370                 1375                 1380         


<210> 43
<211> 1272
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12c sequence"

<400> 43
Met Lys Lys Thr Ser Pro Leu Lys Arg Ser Ala Leu Arg Thr Ala Arg 
1               5                   10                  15      


Arg Gln Ile Ala Arg Gly Cys Leu Pro Ile Gly Asn Arg Asp Ile Ser 
            20                  25                  30          


Thr Thr Arg Thr Arg Val Leu Pro Leu Ala Asp Ser Val Ala Asp Ala 
        35                  40                  45              


Val Trp Asn Gln Ala Arg Thr Ala Ala Leu Thr Leu Arg Gly Phe Gly 
    50                  55                  60                  


Ser Gly Ser Leu Phe Asp Leu Leu Leu Asp Leu His Ala Ser Gly Leu 
65                  70                  75                  80  


Arg Leu Phe Ser Ser Asn Gly Glu Arg Glu Gly Phe Leu Leu Lys Gln 
                85                  90                  95      


Lys Phe Asp Ala Gly Lys Phe Asp Arg Ala Ala Ala Lys Asp Val Gly 
            100                 105                 110         


Glu Asp Met Pro Lys Phe Thr Ala Ala Asn Leu Arg Ala Ala Leu Val 
        115                 120                 125             


Ala Ile Pro Arg Gly Gly Gly Pro Asp Thr Asp Ala Lys Ala Leu Ala 
    130                 135                 140                 


Thr Arg Leu Ala Arg Ala Val Gly Val Lys Ala Thr Lys Leu Asp Lys 
145                 150                 155                 160 


Pro Pro Lys Leu Leu Lys Asp Met Ala Lys Glu Leu Ala Met Ala Phe 
                165                 170                 175     


Pro Thr Trp Lys Glu Leu Ser Thr Ala Asn Gly Glu Val Gly Ala Val 
            180                 185                 190         


Ile Asp Asp Val Ala Arg Met Tyr Gly Leu Arg Trp Pro Ser Leu Arg 
        195                 200                 205             


Arg Gly Trp Ala Phe Arg Leu Pro Glu Val Thr Arg Glu Leu Gly Ser 
    210                 215                 220                 


Pro Thr Leu Ala Phe Asp Pro Asp Ala Pro Val Ile Asp Glu Thr Ser 
225                 230                 235                 240 


Ala Thr Ala Arg Phe Ala Ala Ile Val Ala Arg Tyr Leu Pro Glu Cys 
                245                 250                 255     


Gly Gly Leu Thr Asp Ser Ala Ala Ala Lys Gly Val Gln Ala Arg Ile 
            260                 265                 270         


Thr Thr Thr Asn Ala Asn Gly Leu Ser Trp Leu Phe Gly Val Gly Leu 
        275                 280                 285             


Arg Gly Met Arg Asp Leu Pro Val Asp Thr Val Ala Asp Thr Leu Ala 
    290                 295                 300                 


Ile Asp Val Thr Arg Gly Arg Asp Ala Leu Arg Ala Leu Val Asn Asp 
305                 310                 315                 320 


Ile Lys Ala Leu Pro Arg Leu Gly Glu Phe Gly Asp Arg Val Tyr Val 
                325                 330                 335     


Glu Ser Arg Ala Thr Leu Gln Gly Ala Val Asp Ser Leu Ile Ala Asn 
            340                 345                 350         


Tyr Val Gly Arg Leu Ala Asp Leu Val Ala Ser Ala Asp Ala Leu Glu 
        355                 360                 365             


His Asp Gln Pro Arg Pro Pro Val Leu Asp Asp Ala Asp Trp Lys Pro 
    370                 375                 380                 


Ala Ile Phe Asp Gly Met Gly Phe Thr Pro Trp Glu Val Glu Asp Met 
385                 390                 395                 400 


Leu Asp Ala Arg Pro Val Glu Val Ala Arg Leu Arg Leu Ala Leu Gly 
                405                 410                 415     


Val Leu Ala Gly Thr Thr Pro Ala Val Ala Gly Asp Phe Ala Arg Ala 
            420                 425                 430         


Leu Ala Asp Val Glu Ala Phe Gly Ala Trp Ala Ala Arg Thr Glu Ala 
        435                 440                 445             


Val Ala Ala Leu Ile Asn Ala Arg Val Lys Val Leu Lys Ala Pro Glu 
    450                 455                 460                 


Ser Leu Arg Leu Arg Gly Val Leu Gly Gly Gly Arg Trp Lys Ala Val 
465                 470                 475                 480 


Val Ser Ile His Pro Asp Glu Gly Glu Pro Ala Gln Val Ile Pro Gln 
                485                 490                 495     


Leu Asp Thr Gln Leu Gln Ala Leu Leu Asp Asp Gly Gln Arg Ala Phe 
            500                 505                 510         


Asp Val Leu Val Ala Asp Tyr Thr Pro Thr Phe Ala Ala Ala Leu Glu 
        515                 520                 525             


His Ala Arg Ser Asp Met Arg Ala Ser Leu Ala Asp Lys Gly Arg Glu 
    530                 535                 540                 


Ala Pro Ser Ala Glu Ser Ile Asp Leu Leu Ala Arg Arg Lys Leu Leu 
545                 550                 555                 560 


Asp Met Val Ala Arg Val Thr Arg Arg Gly Ser Pro Ser Leu Gly His 
                565                 570                 575     


Ala Phe Leu Ala Ala Cys Ala Val Gln Gly Leu Thr Arg Pro Gly Thr 
            580                 585                 590         


Ala Thr Glu Arg Ser Leu Arg Gly His Ile Leu Ser Gly Glu Gln Ala 
        595                 600                 605             


Leu Phe Val His Pro Tyr Ala Arg Ala Arg Ser Ile Val Arg Leu Glu 
    610                 615                 620                 


His Ala Gly Leu Leu Arg Leu Asp Leu Asp Ala Leu Leu Thr Ala Met 
625                 630                 635                 640 


Glu Arg Asp Ala Glu Gln Arg Ala Asp Val Arg Glu Gln Ile Val Leu 
                645                 650                 655     


Arg Phe Thr Arg Gln Ser Leu Leu Leu Gly Gly Leu Pro Gly Arg Ile 
            660                 665                 670         


Arg Leu Ala Lys Val Pro Trp Thr Gln Glu Ala Ala Ala Ala Ser Gly 
        675                 680                 685             


Val Arg Gly Ala Pro Trp Leu Lys Leu His Pro Asp Asp Ala Gly Thr 
    690                 695                 700                 


Val Ala Arg Ser Glu Val Ile Lys Ala Phe Thr Ala Arg Phe His Leu 
705                 710                 715                 720 


Ser Ala Asn Gly Leu Leu Tyr Arg Leu Asn Arg Met Arg Phe Leu Glu 
                725                 730                 735     


Arg Tyr Asp Ile Arg Cys Phe Ile Gly Asp Thr Leu Leu Phe Ala Pro 
            740                 745                 750         


Lys Ala Gly Ala Trp Thr Pro Pro Glu Gln Tyr Arg His Gly Lys Tyr 
        755                 760                 765             


Ala His Trp Leu Ser His Pro Asp Leu Pro Arg Thr Glu Gly Gly Ala 
    770                 775                 780                 


Val Asp Val Val Pro Ala Ala Arg Trp Leu Thr Glu Ala Ser Arg Arg 
785                 790                 795                 800 


Ala Asp Glu Asp Gly Arg Ala Ser Ala Val Ala Leu Leu Ala Gln Phe 
                805                 810                 815     


Pro His Glu Trp Val Ala Ala Cys Glu Phe Glu Gly Ala Pro Val Tyr 
            820                 825                 830         


Glu Gly Val Phe Pro Cys Glu Gly Lys Ile Gly Gly Trp Met Lys Arg 
        835                 840                 845             


Arg Gly Tyr Arg Leu Ala Pro Pro Arg His Phe Ala Gly Glu Leu Leu 
    850                 855                 860                 


Ala Ala Phe Lys Asp Ala Ser Val Ser Pro His Gly Leu Thr Phe Glu 
865                 870                 875                 880 


Arg Glu Met Leu Arg Glu Gly Thr Thr Val Arg Glu Leu Ser Arg Arg 
                885                 890                 895     


Val Val Ala Ala Tyr Pro Ile Ala Val Pro Thr His Pro Asp Ala Glu 
            900                 905                 910         


Arg Pro Trp Ser Pro Leu His Leu Met Gly Leu Asp Leu Gly Glu Ala 
        915                 920                 925             


Gly Leu Gly Val Cys Leu Arg His Ile Gly Thr Gly Ala Glu Thr Thr 
    930                 935                 940                 


Leu Leu Leu Pro Val Arg Lys Thr Arg Leu Leu Ala His Arg Glu Glu 
945                 950                 955                 960 


His Tyr Arg Arg Lys Val Gln Pro Arg Gln Ala Phe Arg Lys Gly Tyr 
                965                 970                 975     


Gly Asp Ala Met Glu Leu Ala Val Lys Ala Ala Ile Gly Glu Val Cys 
            980                 985                 990         


Gly Ile Ile Asp Asn Leu Ile Val  Arg Tyr Arg Ala Val  Pro Val Phe 
        995                 1000                 1005             


Glu Ser  Ala Val Ala Gln Ala  Arg Gly Ser Asn Lys  Met Ile Gln 
    1010                 1015                 1020             


Arg Val  Phe Ala Gly Val Val  Gln His Tyr Thr Phe  Val Ala Asn 
    1025                 1030                 1035             


Asn Gly  Ala Ala Gln Thr Val  Arg Gln Ser His Trp  Phe Gly Ala 
    1040                 1045                 1050             


Gly Arg  Trp Ser Tyr Thr Tyr  Gly Ala Asp Leu Leu  Pro Ala Ala 
    1055                 1060                 1065             


Arg Gln  Met Thr Glu Lys Gln  Leu Leu Lys Ala Lys  Ala Glu Ala 
    1070                 1075                 1080             


Val Phe  Arg Pro Ala Met Gly  Phe Pro Gly Val Met  Ala Ser Gly 
    1085                 1090                 1095             


Tyr Arg  Thr Ser Leu Val Cys  Ala Cys Cys Gly Glu  Asp Val Leu 
    1100                 1105                 1110             


Asp Ala  Val Asp Ala Ala Ala  Glu Gly Gly Gln Val  Ala Leu Thr 
    1115                 1120                 1125             


Thr Asp  Ala Glu Gly Ser Gly  Val Leu Asp Leu Gly  Gly Arg Ser 
    1130                 1135                 1140             


Leu Arg  Ile Lys Leu Glu Ala  Pro Ser Pro Asn Pro  Ile Val Gln 
    1145                 1150                 1155             


Lys Ala  Ala Arg Arg Lys Arg  Arg Arg Thr Pro Trp  Glu Ala Leu 
    1160                 1165                 1170             


Ala Asp  Arg Thr Trp Thr Leu  Thr His Lys Thr Asp  Arg Ala Asp 
    1175                 1180                 1185             


Leu Val  Ala Thr Leu Arg Arg  Gly Leu Arg Arg Pro  Pro Ala Ser 
    1190                 1195                 1200             


Val Gln  Gly His Ala Thr Ser  Gly Trp Glu Phe His  Cys Ala Ala 
    1205                 1210                 1215             


Cys Gly  His Ile Ala Gln Ala  Asp Val Asn Ala Ala  Thr Asn Leu 
    1220                 1225                 1230             


Val Arg  Arg Tyr Asp Asp Arg  Val Arg Lys Met Glu  Gln Ala Arg 
    1235                 1240                 1245             


Ala His  Trp Asp Asp Pro Ser  Val Arg Ala Lys Leu  Ala Ser Glu 
    1250                 1255                 1260             


Leu Ala  Glu Arg Ala Ala Ala  Arg Ser 
    1265                 1270         


<210> 44
<211> 1262
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12c sequence"

<400> 44
Met Leu Thr Thr Lys Phe Lys Leu Glu Leu Pro Ala Gly Cys Pro Leu 
1               5                   10                  15      


Arg Glu Asp Ala Ala Thr Phe Asp Glu Cys Arg Lys Leu Tyr Asp Val 
            20                  25                  30          


Val Glu Gly Cys Gly Asn Gly Thr Leu Thr Gly Phe Leu Phe Ser Val 
        35                  40                  45              


Ile Leu Ser Gly Phe Arg Ile Phe Pro Asp Gly Lys Thr Ala Glu Ile 
    50                  55                  60                  


Phe Ala Asn Arg Ser Val Tyr Asp Glu Asp Glu Phe Arg Ser Ala Leu 
65                  70                  75                  80  


Val Glu Ala Val Gly Ala Pro Leu Pro Arg Phe Thr Val Lys Ala Leu 
                85                  90                  95      


Ile Lys Arg Leu Gln Met Glu Val Arg Ala Arg Gly Asn Lys Asp Asn 
            100                 105                 110         


Arg Phe Val Ala Glu Val Met Met Lys Glu Tyr Arg Gln Thr Leu Cys 
        115                 120                 125             


Gly Lys Thr Leu Pro Lys Gly Val Asp Glu Ser Tyr Val Asp Arg Leu 
    130                 135                 140                 


Phe Glu Glu Met Ala Arg Glu Leu Thr Ser Arg Tyr Arg Ser Trp Asn 
145                 150                 155                 160 


Glu Leu Lys Gly Asp Leu Leu Gly Ala Cys Lys Ala Val Asp Ala Ala 
                165                 170                 175     


Leu Arg Gly Phe Gly Asp Phe Pro Ser Leu Ala Thr Met Val Thr Arg 
            180                 185                 190         


Ala Ala Ala Arg Arg Leu Pro Lys Asp Ser Thr Ile Val Phe Asp Pro 
        195                 200                 205             


Gln Ser Pro Cys Ile Asp Val Gln Thr Ile Gly Val Asp Ala Met Pro 
    210                 215                 220                 


Tyr Ala Ala Val Ser Thr Ile Leu Ser Tyr Pro Glu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Arg Arg Asp Phe Val Gln Asn His Leu Thr Thr Pro Ser Ala Ala 
                245                 250                 255     


Gly Leu Ser Trp Leu Phe Asn Arg Gly Leu Glu Leu Phe Ser Glu Glu 
            260                 265                 270         


Ser Val Glu Glu Leu Cys Arg Leu Phe His Val Pro Glu Asp Gln Arg 
        275                 280                 285             


Thr Arg Ile Val Gln Ile Gln Asn Ala Ala Arg Ala Thr Pro Arg Gln 
    290                 295                 300                 


Ser Phe Phe Leu Lys Lys Gly Gly Ala Pro Leu Gly Tyr His Asp Phe 
305                 310                 315                 320 


Arg Ser Ala Phe Ala Gly Arg Ile Asn Ser Trp Thr Ala Asn Tyr Leu 
                325                 330                 335     


Asn Arg Leu Glu Glu Leu Gln Gly Leu Leu His Asp Leu Thr Asp Glu 
            340                 345                 350         


Leu Arg Leu Pro Asp Leu Val Arg Asn Gly Glu Asp Phe Leu Ala Thr 
        355                 360                 365             


Thr Asp Cys Arg Arg Glu Glu Val Glu Ile Leu Cys Arg Ser Phe Ser 
    370                 375                 380                 


Arg Glu Arg Asp Arg Ala Gln Thr Ala Val Glu His Leu Ile Gly Ala 
385                 390                 395                 400 


Asp Pro Leu Gln Val Val Ser Asp Val Ala Ala Ile Glu Glu Tyr Ser 
                405                 410                 415     


Arg Ile Val Asn Arg Leu Cys Ala Ile Lys Glu Gln Ile Val Asn Ser 
            420                 425                 430         


Leu Arg Gln Ala Glu Asp Asp Lys Ala Ser Arg Trp Thr Ala Leu Trp 
        435                 440                 445             


Ser Glu Val Lys Asp Glu Phe Gln Pro Trp Glu Lys Leu Ile Arg Leu 
    450                 455                 460                 


Pro Lys Leu Asn Gly Met Ser Gly Gly Val Pro Pro Ala Gln Asp Glu 
465                 470                 475                 480 


Leu Glu Thr Ile Leu Ala Arg Tyr Ser Asp Val Gly Arg Gly Ala Ser 
                485                 490                 495     


Glu His Phe Asp Ala Val Met Glu Trp Ala Ala Lys Thr Gly Ala Glu 
            500                 505                 510         


Gly Asp Val Leu Lys Lys Phe Ala Glu Thr Glu Gln Gln Arg Ala Asp 
        515                 520                 525             


Gln Arg Ala Pro Gly Lys Tyr Asp Gly Arg Glu Leu Ala Leu Arg Leu 
    530                 535                 540                 


Val Leu Gln Arg Val Ala Arg Val Val Arg Asp Arg Ser Asp Ala Cys 
545                 550                 555                 560 


Ala Glu Asn Val Arg Gln Trp Phe Leu Lys Glu Asn Val Phe Ala Glu 
                565                 570                 575     


Arg Lys Asp Phe Asn Lys Phe Phe Phe Asn Arg Leu Gly Asn Leu Tyr 
            580                 585                 590         


Val Ser Pro Phe Ser Asn Arg Arg His Ala Gly Tyr Lys Leu Ser Asp 
        595                 600                 605             


Gly Leu Val Glu Arg Ser Gly Ala Val Trp Arg Glu Leu Leu Ala Leu 
    610                 615                 620                 


Val Lys Glu Met Arg Gly Ala Tyr Ala Ser Phe Ser Glu Ala Gly Glu 
625                 630                 635                 640 


Thr Phe Leu Arg Leu Glu Ser Leu Leu Met Gly Met Arg Ile Gly Ala 
                645                 650                 655     


Leu Thr Lys Asn Ile Pro Ala Glu Val Ala Ala Leu Arg Leu Asp Asp 
            660                 665                 670         


Glu Thr Ala Leu Glu Ser Val Ser Glu Gly Leu Lys Leu Gln Leu Gln 
        675                 680                 685             


Gln Ala Glu Val Pro Pro Ser Val Leu Ala Lys Ala Phe Asn Val Tyr 
    690                 695                 700                 


Val Ser Leu Leu Ser Gly Cys Leu Ile Ala Leu Arg Arg Glu Arg Phe 
705                 710                 715                 720 


Phe Leu Arg Thr Lys Phe Ser Phe Val Gly Asn Thr Ala Leu Val Tyr 
                725                 730                 735     


Val Pro Lys Glu Lys Ser Trp Pro Met Pro Ser Arg Tyr Glu Ala Ser 
            740                 745                 750         


Pro Ser Trp Thr Pro Ile Phe Glu Asn Asp Val Leu Val Arg Leu Ser 
        755                 760                 765             


Thr Gly Glu Val Glu Val Ala Glu Thr Phe Arg Arg Ala Val Ala Leu 
    770                 775                 780                 


Trp Gly Arg Thr Thr Asp Pro Val Leu Lys Lys Ala Leu Arg Glu Leu 
785                 790                 795                 800 


Phe His Gln Leu Pro His Asp Trp Cys Cys Gln Val Ser Val Arg Ser 
                805                 810                 815     


Ser Gly Asp Met Thr Pro Ala Lys Arg Lys Glu Asp Asp Arg Asp Val 
            820                 825                 830         


Leu Ile Val Glu Lys Lys Gly Lys Tyr Asp Ser Thr Ile Ile Ser Lys 
        835                 840                 845             


Lys Ile Ala Ala Thr Ala Leu Val Arg Leu Val Gly Pro Ser Thr His 
    850                 855                 860                 


Lys Glu Arg Leu Asn Arg Leu Leu Leu Asp Val Gly Glu Val Ala Cys 
865                 870                 875                 880 


Asp Met Thr Leu Leu Ala Asp Gln Glu Ile Leu Gln Lys Val Glu Asp 
                885                 890                 895     


Asp Arg Val His Leu Ser Pro Gly Lys Leu Gln Phe Ser Leu Ser Val 
            900                 905                 910         


Pro Ile Ser Thr Pro Ala Glu Gln Cys Glu Asp Glu Val Lys Ser Glu 
        915                 920                 925             


Arg Lys Ser Thr His Phe Arg Arg Ile Val Ala Ile Asp Gln Gly Glu 
    930                 935                 940                 


Arg Gly Phe Ala Phe Ala Val Phe Arg Leu Glu Asp Ala Gly Lys Lys 
945                 950                 955                 960 


Gly Ala Gln Pro Ile Ala Gln Gly Phe Val Asn Ile Pro Ser Ile Arg 
                965                 970                 975     


Arg Leu Ile Ala Arg Val His Ser Tyr Arg Lys Gly Lys Gln Ser Val 
            980                 985                 990         


Gln Lys Phe Ser Gln Arg Phe Asp  Ser Thr Met Phe Thr  Leu Arg Glu 
        995                 1000                 1005             


Asn Val  Ala Gly Asp Val Cys  Gly Ala Ile Ala Gly  Leu Met Ser 
    1010                 1015                 1020             


Arg Tyr  Arg Ala Phe Pro Val  Leu Glu Arg Gln Val  Ser Asn Leu 
    1025                 1030                 1035             


Ala Ser  Gly Gly Lys Gln Leu  Glu Leu Val Tyr Lys  Met Val Asn 
    1040                 1045                 1050             


Ala Arg  Phe Leu Asp Asp Arg  Ile Pro Met His Ser  Leu Glu Arg 
    1055                 1060                 1065             


Thr Ser  Trp Trp Cys Gly Thr  Ser Asp Trp Val Ile  Pro Asp Leu 
    1070                 1075                 1080             


Trp Val  Glu Val Pro Glu Ser  Tyr Ala Val Lys Ala  Lys Lys Asp 
    1085                 1090                 1095             


Glu Ile  Leu Glu Lys Asp Gly  Lys Phe Tyr Arg Thr  Leu Arg Ile 
    1100                 1105                 1110             


Thr Pro  Gly Ala Gly Val Asn  Ala Lys Trp Thr Ser  Arg Ile Cys 
    1115                 1120                 1125             


Ser Gln  Cys Gly Gly Asn Ala  Met Glu Leu Ile Glu  Lys Ala Arg 
    1130                 1135                 1140             


Glu Glu  Lys Val Lys Thr Val  Thr Leu Asp Ala Asn  Gly Glu Val 
    1145                 1150                 1155             


Thr Leu  Phe Gly Arg Thr Leu  Arg Leu Tyr Lys Arg  Pro Ser Glu 
    1160                 1165                 1170             


Glu Arg  Ser Arg Glu Ala Arg  Arg Arg Asn Glu Arg  Ala Pro Trp 
    1175                 1180                 1185             


Thr Glu  Pro Arg Ala Asp Val  Arg Leu Ser Leu Asp  Asp Phe Arg 
    1190                 1195                 1200             


Arg Ala  Val Ala Glu Asn Met  Arg Arg Gln Pro Lys  Ser Leu Gln 
    1205                 1210                 1215             


Ser Arg  Asp Thr Ser Gln Ser  Arg Tyr Phe Cys Val  Phe Thr Asp 
    1220                 1225                 1230             


Cys Arg  Cys His Asn Lys Glu  Gln His Ala Asp Ile  Asn Ala Ala 
    1235                 1240                 1245             


Val Asn  Ile Gly Arg Arg Phe  Leu Glu Ser Leu Leu  Arg Glu 
    1250                 1255                 1260         


<210> 45
<211> 1262
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12c sequence"

<400> 45
Met Arg Arg Gln His His Gly Gly Gln Asn Ala Arg Asp Trp Arg Arg 
1               5                   10                  15      


Lys Val Ala Ala Ala Ala Leu Arg Gln Lys Glu Ser Val Phe Thr Tyr 
            20                  25                  30          


Lys Phe Gly Leu Ser Val Asn Asp Gly Asp Phe Asp Phe Asp Ala Ala 
        35                  40                  45              


Ala Arg Thr Tyr Asp Ile Thr Glu Gly Ile Glu Arg Gly Ser Leu Ile 
    50                  55                  60                  


Gly Leu Val Cys Ala Val His Leu Ser Gly Phe Arg Leu Phe Ser Lys 
65                  70                  75                  80  


Val Ala Glu Thr Arg Gln Phe Leu Asn Arg Ser Arg Tyr Pro Glu Asn 
                85                  90                  95      


Glu Phe Ala Gln Ala Leu Ala Ala His Thr Glu Ile Glu Asn Pro Ser 
            100                 105                 110         


Val Thr Val Gln Ser Ile Glu Ser Val Phe Val Thr Pro Pro Arg Lys 
        115                 120                 125             


Gln Asp Gly Val Ala Arg Leu Trp Ser Ala Asp Glu Leu Ala Lys Arg 
    130                 135                 140                 


Leu Phe Gln Thr Trp Asn Asn Arg Ser Pro Arg Glu Gly Glu Arg Asn 
145                 150                 155                 160 


His Pro Glu Leu Leu Leu Ala Gln Gly Ile Ala Arg Ala Val Thr Lys 
                165                 170                 175     


Ala Phe Ser Gly Trp Lys Glu Leu Ala Asp Asn Ala Val His Ala Leu 
            180                 185                 190         


Thr Cys Ala Asp Asn Tyr Leu Ala Thr Leu Gly Asn Arg Phe Pro Lys 
        195                 200                 205             


Leu Ser Asp Leu Pro Pro Leu Thr Ala Gly Ser Thr Gln Thr Gly Thr 
    210                 215                 220                 


Leu Ala Phe Asp Pro Glu Ser Pro Phe Leu Asn Met Thr Gly Asn Glu 
225                 230                 235                 240 


Asp Ile Trp Leu His Gln Val Val Ala Val Cys Ala Gly Arg Leu Lys 
                245                 250                 255     


Arg Tyr Met Pro Glu Ile Asp Pro Ser Ser Arg Lys Phe Ala Ser Arg 
            260                 265                 270         


Leu Thr Asp Ser Ile Val Ser Ser Gln Asn Asn Gly Leu Ser Trp Leu 
        275                 280                 285             


Phe Gly Asn Gly Leu Arg Phe Leu Arg Gln Ser Ser Ile Ala Gln Ile 
    290                 295                 300                 


Ala Glu Thr Leu Ser Val Ser Gln Asn Glu His Arg Arg Val Glu Gln 
305                 310                 315                 320 


Leu Lys Glu Phe Ala Asp Ala Ile Pro Val Asn Pro Phe Phe Ala Thr 
                325                 330                 335     


Asp Gly Tyr Ala Glu Phe Arg Gly Ser Val Gly Gly Lys Ile Ser Ser 
            340                 345                 350         


Trp Val Ser Asn Tyr Trp Lys Arg Ile Cys Glu Leu Thr Val Leu His 
        355                 360                 365             


Ser Gln Pro Pro Asp Ile Thr Ile Pro Glu Gly Leu Leu Ala Ser Glu 
    370                 375                 380                 


Asn Ala Thr Leu Phe Ser Gly Gln His Thr Ala Ala Ala Gly Leu Val 
385                 390                 395                 400 


Ala Leu Ser Ala Arg Leu Pro Ser Gln Val Arg Asp Ala Gly Lys Ala 
                405                 410                 415     


Leu Phe Val Leu Ser Gly Asp Gly Val Pro Arg Ala Asp Asp Ile Ala 
            420                 425                 430         


Thr Val Glu Asp Val Ala Gly Glu Leu Ala Glu Leu Thr Gly Gln Leu 
        435                 440                 445             


Ala Met Leu Asp Asn Arg Ile Gln Gln Glu Ile Glu Arg Ala Gln Asp 
    450                 455                 460                 


Ala Asn Asp Glu Gly Arg Val Gly Ser Leu Ala Ser Leu Arg Pro Asn 
465                 470                 475                 480 


Pro Thr Lys Glu Leu Lys Glu Pro Pro Lys Leu Asn Arg Ile Ser Gly 
                485                 490                 495     


Gly Thr Ala Asp Ala Ala Gly Glu Leu Ala Arg Leu Glu Thr Ser Leu 
            500                 505                 510         


Asn Asp Leu Ile Arg Ala Arg Arg Glu His Phe Tyr Arg Leu Ala Glu 
        515                 520                 525             


Trp Thr Gly Asn Thr Ala Ser Leu Asp Pro Leu Pro Ala Leu Ala Glu 
    530                 535                 540                 


Arg Glu Arg Lys Ala Leu Thr Asp Arg Gly Met Asp Pro Thr Leu Ala 
545                 550                 555                 560 


Glu Ala Asp Glu Tyr Ala Leu Arg Arg Leu Leu His Arg Ile Ala Gly 
                565                 570                 575     


Met Ala Arg Arg Leu Ser Pro Asn Glu Ala Lys Arg Val Arg Glu Thr 
            580                 585                 590         


Met Thr Pro Leu Phe Leu Lys Lys Arg Glu Ala Asn Leu Tyr Phe His 
        595                 600                 605             


Asn Arg Ala Gly Ala Leu Tyr Arg His Pro Phe Ser Asn Ser Arg His 
    610                 615                 620                 


Gln Pro Tyr Ser Ile Asp Leu Asn Arg Ala Arg Ala Thr Asp Trp Leu 
625                 630                 635                 640 


Ala Trp Leu Glu Glu Arg Ala Arg Glu Met Leu Gly Leu Leu Gly Ser 
                645                 650                 655     


Gly Ala Pro Ala Asn His Glu Tyr Leu Arg Asp Leu Leu Ser Ile Glu 
            660                 665                 670         


Thr Phe Val Phe Thr Thr Arg Leu Ser Gly Leu Pro Ala Gln Val Pro 
        675                 680                 685             


Gly Tyr Leu Ala Lys Pro Lys Ser Asp Leu Thr Asn Ile Pro Pro Leu 
    690                 695                 700                 


Leu Ala Ala Gln Leu Asp Val Asp Glu Val Ser Arg Asp Val Ala Leu 
705                 710                 715                 720 


Arg Ala Phe Asn Leu Phe Asn Ser Ala Ile Asn Gly Leu Ser Phe Arg 
                725                 730                 735     


Ala Phe Arg Asp Ser Phe Ile Val Arg Thr Lys Phe Leu Arg Leu Gly 
            740                 745                 750         


His Asp Glu Leu Phe Tyr Val Pro Lys Ala Arg Ala Trp Lys Pro Pro 
        755                 760                 765             


Ala Asp Tyr Arg Ser Ala Lys Gly Lys Ile Ser Lys Gly Leu Ala Leu 
    770                 775                 780                 


Pro Ala Val Lys Arg Asn Glu Ala Gly Ser Ile Leu Pro Arg Glu Thr 
785                 790                 795                 800 


Thr Gln Gly Leu Ser Arg Ala Lys Phe Pro Glu Gly Ser His Ala Leu 
                805                 810                 815     


Leu Ser Gln Ala Pro His Asp Trp Phe Val Glu Leu Asp Leu Arg His 
            820                 825                 830         


Asp Lys Met Pro Gln Leu Ala Gly Leu Pro Val Lys Met Asn Ala Asp 
        835                 840                 845             


Gly Leu Lys Gly Trp Arg Ala Arg Arg Arg Pro Thr Phe Arg Leu Ala 
    850                 855                 860                 


Gly Pro Pro Ser Phe Lys Thr Trp Leu Asp Arg Ala Leu Thr Ser Thr 
865                 870                 875                 880 


Ala Val Lys Leu Gly Asp Tyr Thr Leu Ile Leu Asp Gln Ser Phe Lys 
                885                 890                 895     


Gln Ser Leu Arg Val Glu Asp Gly Glu Val Arg Leu Ser Ala Glu Pro 
            900                 905                 910         


Ala Gly Ile Lys Ala Glu Ile Ala Val Pro Val Ile Asp Ala Arg Pro 
        915                 920                 925             


Phe Pro Glu Thr Glu Ala Glu Ala Leu Phe Asp Asn Ile Ile Gly Ile 
    930                 935                 940                 


Asp Leu Gly Glu Arg Arg Ile Gly Tyr Ala Val Phe Ser Leu Pro Ala 
945                 950                 955                 960 


Leu Leu Lys Ser Gly Asn Pro Thr Arg Val Lys Pro Thr Val Val Gly 
                965                 970                 975     


Ser Val Ala Ile Pro Ala Phe Arg Arg Leu Met Ala Ala Val Arg Arg 
            980                 985                 990         


His Arg Gly Ser Arg Gln Pro Asn  Gln Lys Val Ser Gln  Thr Tyr Ser 
        995                 1000                 1005             


Thr Ala  Leu Gln Gln Phe Arg  Glu Asn Val Val Gly  Asp Val Cys 
    1010                 1015                 1020             


Asn Arg  Ile Asp Thr Leu Cys  Glu Arg Tyr Arg Ala  Phe Pro Val 
    1025                 1030                 1035             


Leu Glu  Ser Ser Val Ala Asn  Phe Glu Thr Gly Ala  Asn Gln Leu 
    1040                 1045                 1050             


Lys Leu  Ile Tyr Gly Thr Val  Leu Arg Arg Tyr Thr  Phe Ser Asn 
    1055                 1060                 1065             


Val Asp  Ala His Lys Ser Ala  Arg Ser Ala Tyr Trp  Tyr Ser Ala 
    1070                 1075                 1080             


Asn Arg  Trp Gln His Pro Tyr  Leu Phe Val Arg Glu  Trp Asn Lys 
    1085                 1090                 1095             


Ala Gln  Arg Thr Phe Thr Gly  Ser Ala Lys Pro Leu  Ala Ile Tyr 
    1100                 1105                 1110             


Pro Gly  Val Thr Ile His Pro  Ala Gly Thr Ser Gln  Ile Cys His 
    1115                 1120                 1125             


Arg Cys  Gly Arg Asn Ala Leu  Arg Ala Leu Arg Asn  Met Pro Asp 
    1130                 1135                 1140             


Arg Thr  Ile Arg Val Gly Lys  Asp Gly Leu Ile Val  Leu Ala Asp 
    1145                 1150                 1155             


Ser Thr  Ile Arg Leu Leu Glu  Arg Ala Asp Tyr Ser  Asp Arg Glu 
    1160                 1165                 1170             


Leu Lys  Thr Phe Lys Arg Arg  Lys Gln Arg Pro Pro  Leu Asn Met 
    1175                 1180                 1185             


Pro Val  Pro Glu Gly Ala Arg  Pro Arg Asp Gln Leu  Glu Arg Val 
    1190                 1195                 1200             


Leu Arg  Arg Asn Met Arg Gln  Gln Pro Gln Ser Glu  Met Ser Pro 
    1205                 1210                 1215             


Asp Thr  Thr Gln Ala Arg Phe  Thr Cys Val Tyr Thr  Asp Cys Gly 
    1220                 1225                 1230             


Phe Glu  Gly His Ala Asp Glu  Asn Ala Ala Val Asn  Ile Gly Arg 
    1235                 1240                 1245             


Arg Phe  Leu Glu Arg Ile Asp  Ile Glu Ala Ser Ser  Arg Thr 
    1250                 1255                 1260         


<210> 46
<211> 1283
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12c sequence"

<400> 46
Met Thr His Ala Lys Lys Ile Pro Phe Pro Val Leu Lys Arg Ser Thr 
1               5                   10                  15      


Leu Arg Lys Ala Arg Gln Arg Ile Ala Ala Gly Ser Ile Thr Ala Gly 
            20                  25                  30          


Glu Arg Pro Phe Asn Ser Thr Val Thr Arg Val Val Pro Val Lys Asp 
        35                  40                  45              


Pro Val Ser Asp Gln Val Trp Ala Val Ala Arg Glu Ala Ala Met Thr 
    50                  55                  60                  


Leu Arg Gly Phe Gly Gln Gly Ser Leu Phe Asp Met Leu Ile His Leu 
65                  70                  75                  80  


His Ala Asp Gly Phe Arg Leu Phe Pro Ser Gly Arg Glu Arg Glu Ala 
                85                  90                  95      


Phe Phe Leu Lys Asp Leu Phe Asp Pro Thr Glu Phe Asp Asp Gly Ala 
            100                 105                 110         


Arg Arg Ala Phe Gly Asp Val Met Pro Gly Phe Thr Ala Asn Ser Leu 
        115                 120                 125             


Arg Glu Ile Leu Gly Ala Pro Ala Arg Lys Cys Gly Lys Val Thr Ser 
    130                 135                 140                 


Val Glu Ile Leu Leu Pro Arg Leu Ser Lys Gly Leu Gly Val Lys Lys 
145                 150                 155                 160 


Ser Ala Ala Pro Pro Glu Val Leu Ser Ser Leu Ala Ala Ala Leu Cys 
                165                 170                 175     


Glu Ala Phe Pro Thr Trp Ser Leu Leu Thr Ala Val Asp Gly Gly Val 
            180                 185                 190         


Gly Lys Val Ile Asp Asp Val Leu Arg Thr His Gly Ser Arg Leu Pro 
        195                 200                 205             


Ser Leu Glu Lys Ala Trp Ser Thr Asn Leu Pro Glu Val Pro Lys Gly 
    210                 215                 220                 


Leu Gly Val Pro Thr Leu Ala Phe Asp Asp Gln Ala Pro Ala Gln Ser 
225                 230                 235                 240 


Glu Gln Thr Pro Thr Gly Arg Phe Ala Gly Val Val Ala Arg Tyr Leu 
                245                 250                 255     


Ala Glu Thr Phe Ala Ser Asn Pro Glu Ala Thr Ala Gly Asp Ala Ser 
            260                 265                 270         


Lys Ala Val Gln Ala Lys Val Thr Thr Pro Asn Gly Asn Ala Leu Ser 
        275                 280                 285             


Trp Leu Phe Ala Val Gly Arg Arg Ala Met Cys Ser Thr Thr Leu Asp 
    290                 295                 300                 


Glu Leu Ala Ile Gly Leu Asn Ile Thr Ser Pro Arg Gly Arg His Ala 
305                 310                 315                 320 


Leu Ser Ser Leu Lys Glu Arg Met Met Ala Leu Pro Ala Leu Ser Val 
                325                 330                 335     


Leu Gly Glu Arg Ala Tyr Pro Asp Ser Arg Ala Thr Leu Gln Gly Thr 
            340                 345                 350         


Val Asp Ser Leu Ile Ala Asn Tyr Val Asn Arg Leu Phe Glu Leu Ser 
        355                 360                 365             


Ser Ser Ala Thr Ser Ile Ala Gln Thr Lys Leu Ile Leu Pro Ala Ala 
    370                 375                 380                 


Ile Gln Gly Asp Thr Ala Val Phe Asp Gly Met Pro Phe Ser Ala Glu 
385                 390                 395                 400 


Asp Val Gly Ala Leu Phe Glu Gln Leu Pro Ser Glu Ile Ala Lys Leu 
                405                 410                 415     


Glu His Ala Val Lys Val Leu Val Gly Lys Glu Arg Thr Ser Thr Leu 
            420                 425                 430         


Gly Tyr Gln Lys Ala Val Asp Asp Val Asp Glu Phe Gly Val Trp Ala 
        435                 440                 445             


Ser Ser Val Asp Ala Val Ile Gly Gln Ile Asn Ala Arg Leu Lys Thr 
    450                 455                 460                 


Leu Glu Arg Ala Gln Glu Pro Leu Gly Lys Leu Met Gly Asp Gly Lys 
465                 470                 475                 480 


Leu Lys Arg Leu Val Asn Ile His Glu Pro Glu Gly Pro Ala Val Glu 
                485                 490                 495     


Ile Ile Pro Val Leu Asp Gln Glu Leu Gln Asp Val Leu Thr Ser Cys 
            500                 505                 510         


Arg Thr Ala Phe Ala Asp Leu Glu Ala Arg Tyr Pro Met Thr Val Ala 
        515                 520                 525             


Lys Ala Gln Arg His Ala Glu Ala Glu Val Arg Asn Ala Leu Glu Leu 
    530                 535                 540                 


Ala Ser Arg Lys Glu Gly Gly Leu Ser Leu Ala Ser Ala Asp Val Pro 
545                 550                 555                 560 


Ala Leu Ala Lys Arg Lys Ile Leu Glu Pro Ile Ile Ser Ile Ala Arg 
                565                 570                 575     


Arg Ser Ser Pro Ala Met Ala Thr Ala Val Leu Thr Glu Cys Leu Arg 
            580                 585                 590         


Gln Lys Leu Ile Val Lys Gly Thr Gly Ser Glu Arg Ser Leu Arg Gly 
        595                 600                 605             


Tyr Val Leu Ser Gly Glu Gln Val Ile Tyr Ala His Pro Leu Ser Arg 
    610                 615                 620                 


Arg Arg Ser Ile Val Arg Leu Asp Arg Glu Gly Leu Gln Asn Phe Asp 
625                 630                 635                 640 


Ala Leu Glu Phe Leu Asp Ala Leu Gln Lys Asp Ala Thr Gln Arg Thr 
                645                 650                 655     


Asn Val Arg Glu Ser Leu Ile Val Glu Met Ala Arg Gln Ser Leu Leu 
            660                 665                 670         


Leu Ser Ala Leu Pro Asp Arg Ile Glu Ile Gly Ala Ile Ser Trp Gln 
        675                 680                 685             


Thr Pro Ser Gln Asn Gln His Ala Pro Trp Ala Asn Leu Arg Pro Val 
    690                 695                 700                 


Asn Gly Thr Val Gly Arg Ser Glu Thr Ile Lys Ser Phe Thr Ala Val 
705                 710                 715                 720 


Phe His Ser Arg Ile Ser Gly Leu Leu Tyr Arg Leu Asn Arg Gln Lys 
                725                 730                 735     


Phe Met Glu Lys Tyr Asp Leu Arg Cys Phe Ile Gly Ser Thr Leu Leu 
            740                 745                 750         


Phe Ser Pro Lys Asn Ala Asp Trp Ala Pro Pro Pro Gln Tyr Arg His 
        755                 760                 765             


Gly Arg Phe Ser Ala Leu Leu Ala Arg Ser Asp Phe Pro Trp Glu Gly 
    770                 775                 780                 


Ala Glu Gly Thr His Ala Asn Ala Val Arg Leu Ala Lys Phe Leu Ile 
785                 790                 795                 800 


Asp Glu Thr Arg Asn Ala Thr Asp Leu Gln Gln Ala Ile Ala Ala Lys 
                805                 810                 815     


Ala Leu Leu Ala Gln Leu Pro His Asp Trp Val Val Cys Cys Asp Phe 
            820                 825                 830         


Asp Gly Ala Pro Ser Tyr Glu Gly Ala Phe Val Ser Ala Gly Glu Val 
        835                 840                 845             


Ser Ala Trp Ala Lys Arg Ser Gly Tyr Leu Leu Thr Pro Pro Arg His 
    850                 855                 860                 


Phe Ala Gly Ala Phe Leu Glu Gly Phe Lys Ser Thr Lys Ile Ser Pro 
865                 870                 875                 880 


His Gly Leu Thr Phe Glu Arg Met Leu Glu Arg Asp Gly Asp Ser Val 
                885                 890                 895     


Ile Glu Thr Gly Arg Arg Val Thr Ala Ala Phe Pro Ile Thr Gln Glu 
            900                 905                 910         


Val Ala Pro Ala Ala Gln Pro Trp Lys Pro Arg His Leu Ala Gly Leu 
        915                 920                 925             


Asp Leu Gly Glu Ala Gly Leu Gly Val Cys Leu Lys Asn Leu Asp Asn 
    930                 935                 940                 


Gly His Glu Gln Thr Leu Leu Leu Lys Thr Arg Lys Thr Arg Leu Leu 
945                 950                 955                 960 


Ala His Ser Ala Glu His Tyr Arg Arg Lys Asp Gln Pro Arg Gln Val 
                965                 970                 975     


Phe Arg Lys Gln Tyr Asn Gln Ser Ser Glu Asn Ala Ile Lys Ala Ala 
            980                 985                 990         


Ile Gly Glu Val Cys Gly Leu Ile  Asp Asn Leu Ile Ala  Arg Tyr Asp 
        995                 1000                 1005             


Ala Val  Pro Val Phe Glu Ser  Gln Ala Ala Ala Ala  Arg Gly Ser 
    1010                 1015                 1020             


Asn Arg  Met Val Ala Arg Val  Tyr Ala Gly Val Leu  Gln Arg Tyr 
    1025                 1030                 1035             


Thr Tyr  Val Val Gly Asn Gly  Ala Ala Asp Ala Thr  Arg Thr Ser 
    1040                 1045                 1050             


His Trp  Leu Gly Ala Asn Arg  Trp Ser Tyr Ser Phe  Gly Ala Asp 
    1055                 1060                 1065             


Val Ile  Pro Lys Val Arg Asp  Leu Ser Pro Glu Val  Leu Arg Ser 
    1070                 1075                 1080             


Ile Lys  Lys Pro Glu Asn Val  Phe Arg Asp Ala Leu  Gly Phe Pro 
    1085                 1090                 1095             


Gly Val  Leu Ala Asn Ala Trp  Arg Thr Ser Met Ile  Cys Ser Val 
    1100                 1105                 1110             


Cys Gly  Thr Asp Pro Ile Gly  Ala Leu Glu Glu Ala  Ile Ala Ala 
    1115                 1120                 1125             


Asn Gln  Ile Ser Phe Val Thr  Asp Asn Glu Gly Glu  Gly Ser Leu 
    1130                 1135                 1140             


Asp Leu  Gly Asp Gly Arg Lys  Val Thr Leu Arg Val  Glu Val Pro 
    1145                 1150                 1155             


Thr Ser  Ser Ala Leu Thr Lys  Arg Glu Ala Ser Arg  Arg Lys Arg 
    1160                 1165                 1170             


Arg Ala  Pro Trp Glu Ala Lys  Val Gly Thr Val Trp  Thr Leu Thr 
    1175                 1180                 1185             


Arg Lys  Ser His Arg Asp Asp  Leu Leu Thr Thr Ile  Arg Arg Ser 
    1190                 1195                 1200             


Leu Arg  Arg Pro Ser Ser Thr  Phe Gln Gly Ser Thr  Thr Lys Gln 
    1205                 1210                 1215             


Trp Glu  Phe His Cys Pro Cys  Cys Gly Gln Ile Gln  Gln Ala Asp 
    1220                 1225                 1230             


Val Asn  Ala Ala Ser Asn Leu  Val Arg Arg Tyr Phe  Val Arg Ala 
    1235                 1240                 1245             


Ser Asp  Asn Ala Arg Ala Arg  Gln His Trp Ala Asp  Asp Ser Lys 
    1250                 1255                 1260             


Arg Leu  Ala Phe Ile Ala Ser  Met Gly Pro Asp Arg  Ser Ala Arg 
    1265                 1270                 1275             


Glu Glu  Lys Val Ser 
    1280             


<210> 47
<211> 1125
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12d sequence"

<400> 47
Met Arg Lys Lys Leu Phe Lys Gly Tyr Ile Leu His Asn Lys Arg Leu 
1               5                   10                  15      


Val Tyr Thr Gly Lys Ala Ala Ile Arg Ser Ile Lys Tyr Pro Leu Val 
            20                  25                  30          


Ala Pro Asn Lys Thr Ala Leu Asn Asn Leu Ser Glu Lys Ile Ile Tyr 
        35                  40                  45              


Asp Tyr Glu His Leu Phe Gly Pro Leu Asn Val Ala Ser Tyr Ala Arg 
    50                  55                  60                  


Asn Ser Asn Arg Tyr Ser Leu Val Asp Phe Trp Ile Asp Ser Leu Arg 
65                  70                  75                  80  


Ala Gly Val Ile Trp Gln Ser Lys Ser Thr Ser Leu Ile Asp Leu Ile 
                85                  90                  95      


Ser Lys Leu Glu Gly Ser Lys Ser Pro Ser Glu Lys Ile Phe Glu Gln 
            100                 105                 110         


Ile Asp Phe Glu Leu Lys Asn Lys Leu Asp Lys Glu Gln Phe Lys Asp 
        115                 120                 125             


Ile Ile Leu Leu Asn Thr Gly Ile Arg Ser Ser Ser Asn Val Arg Ser 
    130                 135                 140                 


Leu Arg Gly Arg Phe Leu Lys Cys Phe Lys Glu Glu Phe Arg Asp Thr 
145                 150                 155                 160 


Glu Glu Val Ile Ala Cys Val Asp Lys Trp Ser Lys Asp Leu Ile Val 
                165                 170                 175     


Glu Gly Lys Ser Ile Leu Val Ser Lys Gln Phe Leu Tyr Trp Glu Glu 
            180                 185                 190         


Glu Phe Gly Ile Lys Ile Phe Pro His Phe Lys Asp Asn His Asp Leu 
        195                 200                 205             


Pro Lys Leu Thr Phe Phe Val Glu Pro Ser Leu Glu Phe Ser Pro His 
    210                 215                 220                 


Leu Pro Leu Ala Asn Cys Leu Glu Arg Leu Lys Lys Phe Asp Ile Ser 
225                 230                 235                 240 


Arg Glu Ser Leu Leu Gly Leu Asp Asn Asn Phe Ser Ala Phe Ser Asn 
                245                 250                 255     


Tyr Phe Asn Glu Leu Phe Asn Leu Leu Ser Arg Gly Glu Ile Lys Lys 
            260                 265                 270         


Ile Val Thr Ala Val Leu Ala Val Ser Lys Ser Trp Glu Asn Glu Pro 
        275                 280                 285             


Glu Leu Glu Lys Arg Leu His Phe Leu Ser Glu Lys Ala Lys Leu Leu 
    290                 295                 300                 


Gly Tyr Pro Lys Leu Thr Ser Ser Trp Ala Asp Tyr Arg Met Ile Ile 
305                 310                 315                 320 


Gly Gly Lys Ile Lys Ser Trp His Ser Asn Tyr Thr Glu Gln Leu Ile 
                325                 330                 335     


Lys Val Arg Glu Asp Leu Lys Lys His Gln Ile Ala Leu Asp Lys Leu 
            340                 345                 350         


Gln Glu Asp Leu Lys Lys Val Val Asp Ser Ser Leu Arg Glu Gln Ile 
        355                 360                 365             


Glu Ala Gln Arg Glu Ala Leu Leu Pro Leu Leu Asp Thr Met Leu Lys 
    370                 375                 380                 


Glu Lys Asp Phe Ser Asp Asp Leu Glu Leu Tyr Arg Phe Ile Leu Ser 
385                 390                 395                 400 


Asp Phe Lys Ser Leu Leu Asn Gly Ser Tyr Gln Arg Tyr Ile Gln Thr 
                405                 410                 415     


Glu Glu Glu Arg Lys Glu Asp Arg Asp Val Thr Lys Lys Tyr Lys Asp 
            420                 425                 430         


Leu Tyr Ser Asn Leu Arg Asn Ile Pro Arg Phe Phe Gly Glu Ser Lys 
        435                 440                 445             


Lys Glu Gln Phe Asn Lys Phe Ile Asn Lys Ser Leu Pro Thr Ile Asp 
    450                 455                 460                 


Val Gly Leu Lys Ile Leu Glu Asp Ile Arg Asn Ala Leu Glu Thr Val 
465                 470                 475                 480 


Ser Val Arg Lys Pro Pro Ser Ile Thr Glu Glu Tyr Val Thr Lys Gln 
                485                 490                 495     


Leu Glu Lys Leu Ser Arg Lys Tyr Lys Ile Asn Ala Phe Asn Ser Asn 
            500                 505                 510         


Arg Phe Lys Gln Ile Thr Glu Gln Val Leu Arg Lys Tyr Asn Asn Gly 
        515                 520                 525             


Glu Leu Pro Lys Ile Ser Glu Val Phe Tyr Arg Tyr Pro Arg Glu Ser 
    530                 535                 540                 


His Val Ala Ile Arg Ile Leu Pro Val Lys Ile Ser Asn Pro Arg Lys 
545                 550                 555                 560 


Asp Ile Ser Tyr Leu Leu Asp Lys Tyr Gln Ile Ser Pro Asp Trp Lys 
                565                 570                 575     


Asn Ser Asn Pro Gly Glu Val Val Asp Leu Ile Glu Ile Tyr Lys Leu 
            580                 585                 590         


Thr Leu Gly Trp Leu Leu Ser Cys Asn Lys Asp Phe Ser Met Asp Phe 
        595                 600                 605             


Ser Ser Tyr Asp Leu Lys Leu Phe Pro Glu Ala Ala Ser Leu Ile Lys 
    610                 615                 620                 


Asn Phe Gly Ser Cys Leu Ser Gly Tyr Tyr Leu Ser Lys Met Ile Phe 
625                 630                 635                 640 


Asn Cys Ile Thr Ser Glu Ile Lys Gly Met Ile Thr Leu Tyr Thr Arg 
                645                 650                 655     


Asp Lys Phe Val Val Arg Tyr Val Thr Gln Met Ile Gly Ser Asn Gln 
            660                 665                 670         


Lys Phe Pro Leu Leu Cys Leu Val Gly Glu Lys Gln Thr Lys Asn Phe 
        675                 680                 685             


Ser Arg Asn Trp Gly Val Leu Ile Glu Glu Lys Gly Asp Leu Gly Glu 
    690                 695                 700                 


Glu Lys Asn Gln Glu Lys Cys Leu Ile Phe Lys Asp Lys Thr Asp Phe 
705                 710                 715                 720 


Ala Lys Ala Lys Glu Val Glu Ile Phe Lys Asn Asn Ile Trp Arg Ile 
                725                 730                 735     


Arg Thr Ser Lys Tyr Gln Ile Gln Phe Leu Asn Arg Leu Phe Lys Lys 
            740                 745                 750         


Thr Lys Glu Trp Asp Leu Met Asn Leu Val Leu Ser Glu Pro Ser Leu 
        755                 760                 765             


Val Leu Glu Glu Glu Trp Gly Val Ser Trp Asp Lys Asp Lys Leu Leu 
    770                 775                 780                 


Pro Leu Leu Lys Lys Glu Lys Ser Cys Glu Glu Arg Leu Tyr Tyr Ser 
785                 790                 795                 800 


Leu Pro Leu Asn Leu Val Pro Ala Thr Asp Tyr Lys Glu Gln Ser Ala 
                805                 810                 815     


Glu Ile Glu Gln Arg Asn Thr Tyr Leu Gly Leu Asp Val Gly Glu Phe 
            820                 825                 830         


Gly Val Ala Tyr Ala Val Val Arg Ile Val Arg Asp Arg Ile Glu Leu 
        835                 840                 845             


Leu Ser Trp Gly Phe Leu Lys Asp Pro Ala Leu Arg Lys Ile Arg Glu 
    850                 855                 860                 


Arg Val Gln Asp Met Lys Lys Lys Gln Val Met Ala Val Phe Ser Ser 
865                 870                 875                 880 


Ser Ser Thr Ala Val Ala Arg Val Arg Glu Met Ala Ile His Ser Leu 
                885                 890                 895     


Arg Asn Gln Ile His Ser Ile Ala Leu Ala Tyr Lys Ala Lys Ile Ile 
            900                 905                 910         


Tyr Glu Ile Ser Ile Ser Asn Phe Glu Thr Gly Gly Asn Arg Met Ala 
        915                 920                 925             


Lys Ile Tyr Arg Ser Ile Lys Val Ser Asp Val Tyr Arg Glu Ser Gly 
    930                 935                 940                 


Ala Asp Thr Leu Val Ser Glu Met Ile Trp Gly Lys Lys Asn Lys Gln 
945                 950                 955                 960 


Met Gly Asn His Ile Ser Ser Tyr Ala Thr Ser Tyr Thr Cys Cys Asn 
                965                 970                 975     


Cys Ala Arg Thr Pro Phe Glu Leu Val Ile Asp Asn Asp Lys Glu Tyr 
            980                 985                 990         


Glu Lys Gly Gly Asp Glu Phe Ile  Phe Asn Val Gly Asp  Glu Lys Lys 
        995                 1000                 1005             


Val Arg  Gly Phe Leu Gln Lys  Ser Leu Leu Gly Lys  Thr Ile Lys 
    1010                 1015                 1020             


Gly Lys  Glu Val Leu Lys Ser  Ile Lys Glu Tyr Ala  Arg Pro Pro 
    1025                 1030                 1035             


Ile Arg  Glu Val Leu Leu Glu  Gly Glu Asp Val Glu  Gln Leu Leu 
    1040                 1045                 1050             


Lys Arg  Arg Gly Asn Ser Tyr  Ile Tyr Arg Cys Pro  Phe Cys Gly 
    1055                 1060                 1065             


Tyr Lys  Thr Asp Ala Asp Ile  Gln Ala Ala Leu Asn  Ile Ala Cys 
    1070                 1075                 1080             


Arg Gly  Tyr Ile Ser Asp Asn  Ala Lys Asp Ala Val  Lys Glu Gly 
    1085                 1090                 1095             


Glu Arg  Lys Leu Asp Tyr Ile  Leu Glu Val Arg Lys  Leu Trp Glu 
    1100                 1105                 1110             


Lys Asn  Gly Ala Val Leu Arg  Ser Ala Lys Phe Leu  
    1115                 1120                 1125 


<210> 48
<211> 1183
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13a sequence"

<400> 48
Met Pro Ile Val Lys Lys Phe Gly Arg Ser Gln Thr Ser Leu Ser Asp 
1               5                   10                  15      


Arg Lys Ile Val Leu Lys Met Glu Thr Ala Ala Arg Asn Ile Pro Asp 
            20                  25                  30          


Phe Leu Leu Ser Asp Pro Glu Ala Val Ile Gly Gln Trp Ala Ser Ala 
        35                  40                  45              


Met Asp Lys Ile Ala Lys Lys Pro Lys Gly Lys Asp Lys Pro Ser Ser 
    50                  55                  60                  


Tyr Gln Arg Lys Phe Arg Glu Arg Leu Gly Lys Ala Ile Trp Ala Asp 
65                  70                  75                  80  


Leu Thr Gly Pro Glu Gly Pro Leu Arg Asp Val Pro Ala Ala Glu Leu 
                85                  90                  95      


Glu Asp Leu Arg Lys Arg Trp Asp Arg Arg Val His Pro Tyr Pro Asp 
            100                 105                 110         


Gly Thr Lys Asp Gly Pro Lys Pro Ala Thr Pro Lys Gly Arg Leu Tyr 
        115                 120                 125             


Thr Arg Phe Ala Gly Glu Val Gly Tyr Gly Lys Ala Asp Ala Val Ala 
    130                 135                 140                 


Ile Ala Arg Asp Ile Arg Ile His Leu Leu Glu Thr Glu Phe Lys Thr 
145                 150                 155                 160 


Gly Gly Gly Thr Arg Asp Ala Gly Arg Ala Val Arg Arg Ala Ser Ser 
                165                 170                 175     


Ile Glu Lys Asn Val Leu Lys Lys Ala Arg Val Pro Gln Arg Pro Lys 
            180                 185                 190         


Pro Pro Gln Glu Ala Ala Trp Ser Lys Glu Asp Glu Asp Arg Tyr Phe 
        195                 200                 205             


Ile Pro His Asp Val Ala Arg Lys Ile Val Leu Ala Ala Lys Ala Gln 
    210                 215                 220                 


Glu Lys Glu Asp His Arg Val Ala Trp Arg Thr Ala Ala Ala Val Leu 
225                 230                 235                 240 


Phe Glu His Phe Gly Arg Ile Phe Gln Gln Asp Gly Arg Ala Leu Ser 
                245                 250                 255     


Phe Ala Glu Ala Glu Lys Gln Met Pro Gly Leu Leu Ala Leu His Arg 
            260                 265                 270         


Ala Val Glu Gly Tyr Tyr Arg Gln Ala Leu Lys Arg His Arg Lys Asp 
        275                 280                 285             


Arg Arg Glu His Glu Ala Arg Pro Gly Arg Glu Lys Gly Thr Gly Arg 
    290                 295                 300                 


Arg Lys Val Ser Ala Ile Leu Pro Lys Asp Lys Thr Ala Leu Leu Ala 
305                 310                 315                 320 


Leu Ile Gly His Gln His Gln Asn Arg Glu Ile Ala Ala Leu Ile Arg 
                325                 330                 335     


Leu Gly Arg Ile Leu His Tyr Glu Ala Gly Arg Arg Gly Asn Ser Asp 
            340                 345                 350         


Met Val Ala Asn Ile Asn Arg Asn Trp Pro Ala Asp Val Ser Glu Ser 
        355                 360                 365             


His Tyr Trp Thr Ser Ala Gly Gln Ile Glu Ile Lys Arg Asn Glu Ala 
    370                 375                 380                 


Phe Val Arg Ile Trp Arg Ser Ala Leu Ser His Ala Asn Arg Thr Leu 
385                 390                 395                 400 


Gly Asp Trp Leu Ser Pro Asp Glu Val Ala Asn Asp Ile Thr Met Ser 
                405                 410                 415     


Trp Glu Ser Lys His Glu Lys Ser Gly Lys Arg Lys Thr Gly Lys Leu 
            420                 425                 430         


Glu Glu Asn Arg Glu Glu Ala Glu Ala His Ala Pro Val Ile Phe Gly 
        435                 440                 445             


Gly Ser Ala Glu Arg Leu Gly Thr Gly Asp Asp Phe Gln Lys Thr Leu 
    450                 455                 460                 


Glu Ala Ile Cys Glu Val Phe Ser Gln Leu Arg His Ser Ser Phe His 
465                 470                 475                 480 


Phe Arg Gly Leu Asp Gly Phe Lys Asp Ala Leu Thr Lys Thr Val Lys 
                485                 490                 495     


Thr Cys Asp Pro Gly Ala Val Ala Arg Leu Gln Asp Leu His Ala Glu 
            500                 505                 510         


Asp Gln Ala Asn Arg Glu Ala Arg Leu Lys Glu Asp Leu Arg Gly Ala 
        515                 520                 525             


His Ala Glu Leu Phe Leu Asp Glu Gly Arg Leu Ala Glu Ile Trp Ala 
    530                 535                 540                 


Leu Leu His Pro Lys Ser Thr Glu Lys Thr Leu Pro Pro Leu Pro Arg 
545                 550                 555                 560 


Tyr Ser Arg Val Val Thr Arg Ala Glu Asn Thr Cys Asn Gly Leu Lys 
                565                 570                 575     


Leu Pro Lys Ser Val Asn Arg Glu Ser Met Lys Val Pro Ala Ile His 
            580                 585                 590         


Cys Arg Tyr Ile Leu Thr Arg Leu Leu Tyr Gln Ser Gly Phe Arg Thr 
        595                 600                 605             


Trp Ile Ala Glu Ala Pro Ala Ala Gln Leu Asn Arg Trp Ile Glu Thr 
    610                 615                 620                 


Ala Thr Glu Arg Ala Gln Lys Ala Thr Val Gly Ile Thr Lys Asn Glu 
625                 630                 635                 640 


Ala Asp Arg Ala Arg Met Val Gly Gln Ile Lys Val Pro Glu Gly Gln 
                645                 650                 655     


Gly Ile Arg Arg Phe Leu Asp Asp Leu Ala Gly Leu Thr Ala Thr Glu 
            660                 665                 670         


Phe Arg Val Gln Ala Gly Tyr Glu Ser Asp Arg Glu Ala Ala Arg Asp 
        675                 680                 685             


Gln Ala Ala Phe Leu Glu Asn Leu Asn Cys Asp Val Met Ala Leu Ala 
    690                 695                 700                 


Phe Asp Lys Tyr Leu Ser Asp His Lys Leu Gly Trp Leu Ala Gly Ile 
705                 710                 715                 720 


Asp Ala Glu Ser Arg Pro Ser Glu Thr Pro Leu Ser Asn Val Asp Glu 
                725                 730                 735     


Leu Pro Ser Ser Gly Ser Leu Gly Thr Pro Glu Arg Trp Glu Ala Ala 
            740                 745                 750         


Leu Tyr Ala Val Cys His Leu Ile Pro Val Ser Glu Val Gly Arg Leu 
        755                 760                 765             


Leu His Gln Leu Arg Arg Trp Ser Asn Gly Gln Lys Ala Thr Pro Asp 
    770                 775                 780                 


Gly Gly Arg Leu Glu Arg Leu Phe Glu Leu Tyr Leu Asp Met His Asp 
785                 790                 795                 800 


Ala Lys Phe Asp Gly Ser Thr Pro Leu Arg Asp His Asp Asp Leu Ala 
                805                 810                 815     


Val Ile Phe Glu Thr Thr Gly Ile Arg Asp Arg Val Leu Pro Ser Ser 
            820                 825                 830         


Leu Gln His Gly Glu His Glu Arg Leu Pro Leu Arg Gly Leu Arg Glu 
        835                 840                 845             


Met Leu Arg Phe Gly Asn Leu Arg Val Leu Ala Pro Ile Phe Ala Thr 
    850                 855                 860                 


Ala Lys Val Asp Gln Ala Met Ile Gly Glu Leu Glu Gly Leu Glu Ala 
865                 870                 875                 880 


Arg Ile Gly Asp Ala Pro Ser Gln Val Asp Arg Ala Gln Ala Leu Arg 
                885                 890                 895     


Thr Glu Met His Ala Ala Leu Cys Lys Lys Arg Lys Leu Ala His Asp 
            900                 905                 910         


Asp Lys Lys Ser Val Lys Asp Tyr Leu Thr Ser Leu Gln Thr Val Ile 
        915                 920                 925             


Arg His Arg Arg Leu Ala Asn His Val Arg Leu Thr Asn His Val Arg 
    930                 935                 940                 


Thr Asn Glu Ile Leu Met Ser Val Met Gly Arg Leu Ala Asp Phe Ser 
945                 950                 955                 960 


Gly Ile Trp Glu Arg Asp Leu Tyr Phe Val Thr Asn Ala Leu Leu Tyr 
                965                 970                 975     


Gln Ala Gly Leu Thr Pro Cys Asp Val Phe Ser Lys Glu Pro Pro Lys 
            980                 985                 990         


Glu Asn Arg Arg Ser Pro Leu Gln  Glu Phe Glu Asn Gly  Gln Ile Val 
        995                 1000                 1005             


Phe Ala  Leu Arg Lys Met Gln  Ala Gln Cys Asp Thr  His Ala Gly 
    1010                 1015                 1020             


Leu Val  Asp Gln Ile Lys Gly  Glu Thr Ala Arg Leu  Phe His Ile 
    1025                 1030                 1035             


Ala Glu  Gly Ala Pro Gly Asn  Asp Pro Arg Ile Gln  Asn Arg Asn 
    1040                 1045                 1050             


Trp Phe  Ala His Phe Asn Ala  Leu Lys Pro Lys Thr  Gly Asp Arg 
    1055                 1060                 1065             


Leu Asp  Leu Thr Ala Asp Met  Asn Arg Ala Arg Asp  Leu Met Ala 
    1070                 1075                 1080             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Val Ser Ala  Ile Val Thr 
    1085                 1090                 1095             


Leu Leu  Glu Arg Glu Asn Ile  Val Ile Ala Trp Thr  Met Lys Asp 
    1100                 1105                 1110             


His Gln  Leu Thr Asp Ala Val  Leu Ala Ala Lys Ser  Ile Glu His 
    1115                 1120                 1125             


Leu Lys  Gln Asn Lys Ile Arg  Glu Asn Leu Arg Asp  Glu Arg Ser 
    1130                 1135                 1140             


Leu Gly  Tyr Val Ala Ala Leu  Phe Gly Gly Arg Val  Ala Glu Glu 
    1145                 1150                 1155             


Ala Pro  Asp Ile Met His Asp  Arg Thr Val Phe His  Leu Val Gly 
    1160                 1165                 1170             


Ala Leu  Thr Glu Glu Met Glu  Pro Ala Glu 
    1175                 1180             


<210> 49
<211> 1276
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13a sequence"

<400> 49
Met Arg Ile Val Arg Pro Tyr Gly Glu Ser Arg Thr Asp Leu Gly Gly 
1               5                   10                  15      


Glu Arg Gly Gln Thr Arg Val Leu Val Asp Asn Thr Ala Ala Arg Ala 
            20                  25                  30          


Arg His Glu Ile Pro Asp Phe Ala Gln Ser His Asp Ala Leu Val Ile 
        35                  40                  45              


Ala Gln Trp Ile Ser Val Leu Asp Arg Ile Ala Thr Lys Pro Gln Gly 
    50                  55                  60                  


Thr Gln Gly Ala Thr Arg Ala Gln His Ala Phe Arg Asp Arg Leu Gly 
65                  70                  75                  80  


Arg Ala Ala Trp Ala Gln Met Cys Ala Ala Asp Arg Ile Ser Ala Ala 
                85                  90                  95      


Ala Gln Ala Asp Pro Tyr Val Ala Ala Leu Trp Arg Phe Lys Thr His 
            100                 105                 110         


Pro Tyr Gly Asp Ala Lys Tyr Arg Pro Arg Lys Gly Lys Asp Gly Lys 
        115                 120                 125             


Pro Leu Gly Glu Pro Lys Pro Gln Gly Arg Trp Tyr Gly Arg Phe Ala 
    130                 135                 140                 


Ala Asn Ala Glu Pro Glu Gln Ala Asp Val Ala Ala Ile Ala Ala Leu 
145                 150                 155                 160 


Met Asp His His Leu His Val Ala Glu Leu Arg Ile Asp Pro Lys Arg 
                165                 170                 175     


Pro Glu Lys Arg Lys Gly Leu Ile Glu Ala Arg Ala Lys Ser Ile Glu 
            180                 185                 190         


Gly Asn Val Leu Val Ala Glu Pro Arg Lys Arg Pro Val Gly Ser Trp 
        195                 200                 205             


Ser Arg Glu Ala Ile Thr Arg Tyr Phe Met Arg Gln Asp Val Ala Ala 
    210                 215                 220                 


Glu Ile Phe Ala Ala Ala Arg Asp Arg Glu Gln Gly Leu Asn Asp Val 
225                 230                 235                 240 


Pro Arg Gly Pro Val Arg Leu Ala Leu Ala Ala Lys Ile Leu His Gly 
                245                 250                 255     


His Trp Thr Arg Leu Phe His Ala Pro Gly Thr Arg Thr Ala Tyr Ser 
            260                 265                 270         


Ile Arg Glu Ala Glu Glu Lys Glu Pro Glu Leu Phe Ala Leu His Met 
        275                 280                 285             


Ala Val Lys Asp Ala Tyr Ala Lys Leu Leu Lys Arg Arg Thr Gln Pro 
    290                 295                 300                 


Lys Thr Leu Lys Lys Gly Val Lys Pro Pro Gln Gln Ala Pro Val Thr 
305                 310                 315                 320 


Thr Val Leu Pro Lys Asn Ala Gly Glu Leu Leu Arg Leu Val Gln His 
                325                 330                 335     


Arg Ser Arg Asn Arg Asp Leu Ser Ala Leu Ile Arg Arg Gly Lys Leu 
            340                 345                 350         


Ile His Tyr Thr Ala Phe Asp Ile Ala Ala Ala Ala Ala Glu Ala Glu 
        355                 360                 365             


Ser Lys Thr Pro Asp Val Pro Asp Ala Asp Arg Leu Ala Tyr Val Leu 
    370                 375                 380                 


Thr His Trp Pro Asp Asp Leu Ser Ala Ser Arg Tyr Leu Thr Ser Asp 
385                 390                 395                 400 


Gly Gln Ser Ala Ile Lys Arg Ser Glu Ala Phe Val Arg Val Trp Arg 
                405                 410                 415     


His Thr Ile Ala Met Ala Ser Leu Thr Leu Arg Asp Trp Ala Ser Met 
            420                 425                 430         


Asn Asn Asp Leu Gly Asp Val Leu Gly Ser Ala Asn Lys Val Asp Gln 
        435                 440                 445             


Ala Ile Gly Arg Ala Asn Phe Asp Pro Ala Trp His Asp Lys Lys Val 
    450                 455                 460                 


Arg Leu Leu Phe Gly Ala Arg Ala Ala Leu Phe Pro Ser Asp Asp Asp 
465                 470                 475                 480 


Gly Arg Lys Ala Leu Leu Ala Ser Val Ile Arg Ala Gly Leu Ala Leu 
                485                 490                 495     


Arg Asn Ser Ser Phe His Phe Thr Gly Arg Gly Gly Phe Leu Ala Ala 
            500                 505                 510         


Leu Lys Lys Leu Gly Ser Glu Glu Val Met Val Pro Ser Ile Leu Ala 
        515                 520                 525             


Ala Ala His Ala Leu Trp Arg Glu Asp Ala Thr Ala Arg Ala Gly Arg 
    530                 535                 540                 


Leu Arg Ala Ala Leu Thr Gly Ala His Ala Ala His Tyr Phe Glu Glu 
545                 550                 555                 560 


Asp Gln Asn Ala Ser Ile Leu Thr Leu Leu Asp Glu Ala Pro Pro Lys 
                565                 570                 575     


Glu Ser Leu Pro Ile Pro Arg Phe Arg Arg Val Leu Gly Arg Ala Glu 
            580                 585                 590         


Asn Thr Trp Lys Gly Lys Glu Ala Leu Val Leu Pro Pro Thr Ala Asn 
        595                 600                 605             


Arg Arg Gln Leu Glu Asp Pro Ala Arg Arg Cys Arg Tyr Thr Ile Leu 
    610                 615                 620                 


Lys Ala Leu Tyr Glu Arg Pro Phe Arg Ser Trp Leu Ile Ala Arg Ala 
625                 630                 635                 640 


Pro Glu Glu Val Asn Ala Trp Ile Asp Arg Ala Ile Glu Arg Thr Thr 
                645                 650                 655     


Arg Ala Ala Lys Asp Met Asn Ala Lys Arg Gly Glu Asp Asp Lys Arg 
            660                 665                 670         


Ser Val Ile Ala Ala Lys Ala Glu Ser Leu Pro Arg Leu Ser Gly Glu 
        675                 680                 685             


Arg Gly Ile Gly Asp Phe Phe Phe Asp Leu Ser Ser Ala Thr Ala Ser 
    690                 695                 700                 


Glu Met Arg Val Gln Arg Gly Tyr Gly His Asp Gly Glu Ala Ala Lys 
705                 710                 715                 720 


Glu Gln Ala Gly Tyr Ile Asp Asp Leu Leu Cys Asp Val Val Ala Leu 
                725                 730                 735     


Ala Phe Asp Ala Trp Leu Arg Asn Pro Gln Ala Asn Gly Arg Pro Leu 
            740                 745                 750         


Thr Phe Ile Cys Asp Leu Lys Pro Glu Thr Pro Leu Pro Ala Ala Pro 
        755                 760                 765             


Lys Cys Thr Leu Gln Glu Ile Gly Ser Ala Ala Glu Pro Val Arg Pro 
    770                 775                 780                 


Glu Asp Trp Gln Ala Ala Leu Tyr Leu Leu Leu His Leu Val Pro Val 
785                 790                 795                 800 


Gly Glu Ala Gly Arg Leu Leu His Gln Leu Ala Lys Trp Thr Val Thr 
                805                 810                 815     


Ser Arg Leu Ala Asp Asp Leu Leu Asn Ala Asn Val Thr Asp Asp Pro 
            820                 825                 830         


Ser Lys Ala Glu Arg Thr Ala Asp Glu Glu Asp Leu Lys Arg Leu Val 
        835                 840                 845             


His Thr Leu Ile Gln His Leu Asp Met His Asp Ala Lys Phe Glu Gly 
    850                 855                 860                 


Gly Asp Ala Leu Thr Gly Cys Glu Pro Phe Ala Ala Leu Phe Ala Ser 
865                 870                 875                 880 


Arg Pro Gly Phe Ala Arg Ile Phe Pro Ala Glu Ala Asp Glu Arg Leu 
                885                 890                 895     


Asp Arg Arg Val Pro Lys Arg Gly Leu Arg Glu Ile Met Arg Phe Gly 
            900                 905                 910         


His His Gly Leu Val Ala Ser Phe Ala Glu Asp Thr Arg Ile Thr Asp 
        915                 920                 925             


Lys Glu Val Gly Asp Tyr Leu Arg Leu Glu Ile Glu Glu Arg Pro Asp 
    930                 935                 940                 


Asn Val Ala Ala Leu Gln Ala Arg Lys Glu Glu Ala His Glu Arg Trp 
945                 950                 955                 960 


Val Lys Ala Lys Glu Lys Arg Lys Thr Val Asp Pro Lys His Leu Glu 
                965                 970                 975     


Asp Tyr Val Thr Ala Leu Cys Gly Ile Ala Arg His Arg Arg Leu Ala 
            980                 985                 990         


Ser Arg Val Thr Leu Thr Asp Gln  Val Gln Val His Arg  Leu Leu Met 
        995                 1000                 1005             


Thr Val  Leu Gly Arg Leu Val  Asp Phe Ser Gly Met  Phe Glu Arg 
    1010                 1015                 1020             


Asp Leu  Tyr Phe Ala Met Leu  Gly Leu Leu Asp Glu  Lys Gly Ala 
    1025                 1030                 1035             


Arg Pro  Asp Glu Val Phe Ser  Gly Pro Ile Asp Glu  Pro Lys Ser 
    1040                 1045                 1050             


Arg Leu  Ala Leu Leu Ala Asn  Gly Arg Val Leu Ala  Ala Leu Arg 
    1055                 1060                 1065             


Glu Gln  Ile Pro His Ser Lys  Asp Leu Ala Glu Glu  Leu Arg Lys 
    1070                 1075                 1080             


Asp Leu  Glu Arg Leu Phe Gly  Met Asp Cys Ser Gly  Ile Arg Leu 
    1085                 1090                 1095             


Leu Glu  Ala Asp Glu Arg Gly  Asp Thr Cys Leu Arg  Asp Ile Arg 
    1100                 1105                 1110             


Asn Asp  Leu Ser His Phe Asn  Leu Leu His Asp Asp  Ser Phe Ala 
    1115                 1120                 1125             


Leu Asp  Leu Thr Thr Leu Val  Asn Arg Thr Arg Gly  Leu Met Ser 
    1130                 1135                 1140             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Ser Lys Ser  Ile Lys Glu 
    1145                 1150                 1155             


Leu Leu  Ala Arg Glu Gly Leu  Thr Leu Ser Trp Asp  Met Thr Asp 
    1160                 1165                 1170             


Arg His  Asp Leu Glu Asn Ala  Arg Ile Gly Ala Lys  Pro Ala Val 
    1175                 1180                 1185             


His Leu  Gly Gly Arg Lys Leu  Ala Phe Arg Gly Gly  Asp Arg Arg 
    1190                 1195                 1200             


Pro Glu  Pro Val Arg Glu Asn  Leu His Ser Pro Thr  His Leu Glu 
    1205                 1210                 1215             


Ala Val  Ala Arg Leu Phe Gly  Gly Lys Val Val Glu  Glu Asp Asp 
    1220                 1225                 1230             


Val Thr  Asn Leu Asp Leu Ser  Ser Ile Asp Trp Ala  Ala Glu Pro 
    1235                 1240                 1245             


His Asn  Ser Lys Glu Thr His  Arg His Arg Pro Ala  Gly Pro Arg 
    1250                 1255                 1260             


Lys Ser  Pro Pro Lys Arg Arg  Ala Tyr His Ala Pro  Arg 
    1265                 1270                 1275     


<210> 50
<211> 1225
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13a sequence"

<400> 50
Met Arg Ile Ile Lys Pro Tyr Gly Arg Thr Leu Val Glu His Asp Gly 
1               5                   10                  15      


Ala Gly Glu Arg Lys Arg Val Leu Thr Leu Arg Pro Asp His Asp Ser 
            20                  25                  30          


Lys Leu Asp Ile Glu Ala Phe Ala Arg Asp His Asp Glu Leu Val Val 
        35                  40                  45              


Ala Gln Trp Val Ser Thr Ile Asp Lys Ile Ala Ala Lys Pro Gly Pro 
    50                  55                  60                  


Arg Lys Gly Ala Thr Glu Glu Gln Arg Ala Phe Arg Asp Arg Ile Gly 
65                  70                  75                  80  


Lys Ala Ala Trp Ala Leu Leu Val Arg Asn Ala Leu Leu Pro Gly Leu 
                85                  90                  95      


Ala Asp Ala Asp Arg Ala Asp Arg Leu Ala Lys Ile Trp Arg Arg Lys 
            100                 105                 110         


Ile Ala Pro Tyr Gly Asp Leu Arg Pro Asn Glu Arg Pro Ala Ser Ala 
        115                 120                 125             


Lys Gly Arg Trp Tyr Gly Ala Phe Ala Gly Glu Ala Asp Val Ala Asp 
    130                 135                 140                 


Val Asp Ala Gly Glu Ile Ala Ala Lys Ile His Glu His Leu Tyr Asp 
145                 150                 155                 160 


Ala Glu Tyr Arg Ile Ser Gly Asp Gly Arg Lys Pro Asp Gly Cys Ile 
                165                 170                 175     


Ala Ala Arg Ala Arg Ser Ile Ala Val Asn Val Leu Arg Pro Ala Asp 
            180                 185                 190         


Ser Ser Ala Cys Gly Gln Pro Glu Trp Ser Asp Arg Asp Leu Gln Ala 
        195                 200                 205             


Tyr Arg Val Ala Asp Val Ala Lys Gln Ile Trp Asp Ala Ala Leu Ser 
    210                 215                 220                 


Arg Glu Asn Gly Arg Asp Gly Ala Gly Thr Lys Arg Val Thr Asn Ser 
225                 230                 235                 240 


Val Ala Gly Gly Val Leu Phe Glu His Trp Ala Arg Ile Phe Pro Gly 
                245                 250                 255     


Pro Asp Gly Lys Ala Leu Ser Ile Arg Glu Ala Ile Glu Lys Glu Pro 
            260                 265                 270         


Gly Leu Phe Ala Leu His Met Ala Val Lys Asp Cys Tyr Ala Arg Ile 
        275                 280                 285             


Leu Lys His His Lys Lys Lys Ala Pro Gly Arg Arg Glu Arg Glu Asn 
    290                 295                 300                 


Gly Asp Val Ser Pro Ile Arg Lys Val Leu Pro Arg Asp Met Asp Glu 
305                 310                 315                 320 


Leu Phe Ala Arg Ile Ile Ser Gly Arg Gly Asn Arg Asp Leu Asn Ala 
                325                 330                 335     


Leu Val Arg Leu Gly Lys Val Ile His Tyr Thr Ala Ser Asp Pro Asn 
            340                 345                 350         


Ala Asp His Pro Glu Ser Ile Thr Glu Asn Trp Pro Gly Asp Leu Ala 
        355                 360                 365             


Gly Ser His Tyr Trp Thr Ser Ala Gly Gln Ala Glu Ile Lys Arg Asn 
    370                 375                 380                 


Glu Ala Phe Val Arg Val Trp Arg His Val Val Val Leu Ala Ala Arg 
385                 390                 395                 400 


Thr Leu Thr Asp Trp Gly Asp Pro His Gly Glu Ile Gly Ser Asp Ile 
                405                 410                 415     


Leu Gly Lys Ala Asn Asp Ala Thr Gly Ala Lys Phe Asp Glu Ala Ala 
            420                 425                 430         


Phe Asn Arg Lys Cys Ala Leu Leu Phe Gly Lys Arg Ala Ser His Phe 
        435                 440                 445             


Thr Ala Ala Pro Asp Leu Ala Phe Lys Lys Ala Val Leu Lys Thr Ala 
    450                 455                 460                 


Ile Lys Gly Met Ala Ala Leu Arg His Lys Ser Phe His Phe Ala Gly 
465                 470                 475                 480 


Arg Gly Gly Phe Val Lys Ala Leu Glu Gly Ile Gly Gly Leu Asn Glu 
                485                 490                 495     


Ile Asp Arg Phe Pro Asp Val Thr Arg Ala Leu Arg Thr Leu Leu Val 
            500                 505                 510         


Glu Asp Ile Glu Asp Gln Ser Arg Gln Val Arg Ala Thr Met Val Gly 
        515                 520                 525             


Ala His Phe Gly Val Tyr Leu Ser Lys Gly Gln Val Glu Ala Ile Tyr 
    530                 535                 540                 


Arg Ala Val Thr Gly Ala Glu Pro Gly Ser Leu Pro Leu Pro Arg Phe 
545                 550                 555                 560 


Ser Arg Val Leu Arg Arg Ala Lys Gly Ala Trp Glu Ala Glu Asp Val 
                565                 570                 575     


Leu Pro Pro Pro Val Asn Arg Leu Asp Leu Glu Gln Arg Gly Arg Leu 
            580                 585                 590         


Cys Gln Tyr Thr Gly Leu Lys Leu Leu Tyr Glu Arg Pro Phe Arg Arg 
        595                 600                 605             


Trp Leu Glu Gly Arg Ser Ala Ala Lys Leu Asn Gly Phe Ile Tyr Arg 
    610                 615                 620                 


Ala Val Thr Arg Ala Ser Asp Ala Ala Arg Thr Leu Asn Thr Lys Glu 
625                 630                 635                 640 


Ser Asp Asp Trp Arg Asp Ile Ile Val Ala Arg Ala Glu Lys Leu Gly 
                645                 650                 655     


Lys Val Pro Asp Gly Gly Asp Ile His Gly Phe Phe Phe Glu Leu Ser 
            660                 665                 670         


Ala Glu Thr Ala Ser Glu Met Arg Val Gln Gln Ala Tyr Glu Ser Asp 
        675                 680                 685             


Gly Glu Arg Ala Arg Gln Gln Ala Glu Tyr Ile Glu Asp Leu Lys Cys 
    690                 695                 700                 


Asp Val Val Gly Leu Ala Tyr Arg Ser Phe Leu Glu Thr Glu Gly Phe 
705                 710                 715                 720 


Asp Phe Leu Arg Thr Leu Asp Pro Glu Ala Ala Ile Ala Glu Ala His 
                725                 730                 735     


Arg Phe Asp Pro Ala Glu Leu Pro Asp Pro Ala Val Asp Thr Asp Ala 
            740                 745                 750         


Glu Asp Trp Glu Ala Val Leu Tyr Phe Leu Val His Leu Val Pro Val 
        755                 760                 765             


Asp Glu Ile Gly Arg Leu Leu His Gln Met Arg Lys Trp Asp Leu Leu 
    770                 775                 780                 


Ala His Asp Arg Thr Ala Pro Val Ala Asp Gly Gly Gln Ala Arg Leu 
785                 790                 795                 800 


Val Asp Lys Val Gln Arg Val Phe Thr Leu Tyr Leu Asp Leu His Asp 
                805                 810                 815     


Ala Lys Phe Glu Gly Gly Glu Ala Leu Thr Gly Ile Glu Pro Phe Arg 
            820                 825                 830         


Lys Leu Phe Glu Glu Ser Asp Gly Phe Asp Thr Ile Phe Pro Pro Gln 
        835                 840                 845             


Gln Gly Tyr Glu Glu Asp Arg Arg Val Pro Leu Arg Gly Leu Arg Glu 
    850                 855                 860                 


Ile Met Arg Phe Gly Asp Leu Pro Pro Leu Leu Ser Ile Tyr Gly Arg 
865                 870                 875                 880 


Arg Pro Ala Thr Lys Ser Asn Ile Glu Arg Tyr Arg Arg Ala Glu Val 
                885                 890                 895     


Ala Asp Ala Gly Gly Arg Ser Glu Ile Ala Arg Leu Gln Ala Arg Arg 
            900                 905                 910         


Glu Glu Leu His Ala Lys Trp Val Glu Ala Lys Lys Glu Gly Leu Gly 
        915                 920                 925             


Pro Glu Asp Arg Arg Ala Tyr Val Glu Ala Leu Ala Glu Ile Val Arg 
    930                 935                 940                 


His Arg His Leu Ala Ala His Val Thr Leu Thr Asn His Val Arg Leu 
945                 950                 955                 960 


His Arg Leu Met Met Ala Val Leu Gly Arg Leu Ala Asp Phe Ser Gly 
                965                 970                 975     


Leu Trp Glu Arg Asp Leu Tyr Phe Ala Thr Leu Ala Leu Leu His Arg 
            980                 985                 990         


Ala Gly Lys Thr Pro Arg Glu Val  Phe Glu Asn Glu Gly  Ile Asp Leu 
        995                 1000                 1005             


Leu Arg  Asn Gly Gln Ile Val  Tyr Ala Leu Arg Lys  Leu Asn Gly 
    1010                 1015                 1020             


Ser Ser  Asn Ala Ser Ala Leu  Arg Ser Gly Leu Phe  Pro His Phe 
    1025                 1030                 1035             


Gly Ser  Ala Phe Lys Arg Gly  Asp Pro Ile Gly Gly  Ile Arg Asn 
    1040                 1045                 1050             


Ala Phe  Ala His Phe Asn Met  Leu Arg Ala Ala Gln  Pro Pro Asn 
    1055                 1060                 1065             


Leu Thr  Glu Cys Ile Asn Arg  Ala Arg Gln Leu Met  Lys His Asp 
    1070                 1075                 1080             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser Val Ile  Asp Leu Leu 
    1085                 1090                 1095             


Ala Arg  Glu Gly Leu Asn Ile  Ala Trp Ala Val His  Thr Arg Ala 
    1100                 1105                 1110             


Gly Ala  His Asp Leu Ala Glu  Ala Val Leu Ser Ser  Arg Gln Ala 
    1115                 1120                 1125             


Gln His  Leu Gly Lys Leu Arg  Leu Phe Pro Val Ser  Gly Asp Gly 
    1130                 1135                 1140             


Arg Asp  Gly Lys Gly Phe Phe  Ile Met Glu Asp Leu  His Gly Ala 
    1145                 1150                 1155             


Asp Phe  Val Glu Met Ala Ala  Glu Leu Phe Gly Gly  Arg Val Ser 
    1160                 1165                 1170             


Asp Arg  Trp Arg Gly Lys Gly  Cys Val Ser Glu Leu  Arg Leu Asp 
    1175                 1180                 1185             


Ser Ile  Asp Trp Ser Arg Gln  Arg Glu Gln Lys Lys  His Gly Gly 
    1190                 1195                 1200             


Gly Lys  Lys Pro Thr Gly Arg  Ala Arg Lys Ala Asn  Arg Gly His 
    1205                 1210                 1215             


Lys Asn  Arg His Arg Arg Ala  
    1220                 1225 


<210> 51
<211> 1076
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12f sequence"

<400> 51
Met Ser Ala Arg Asn Ile Lys Val Lys Ile Asp Thr Lys Gly Asn Pro 
1               5                   10                  15      


Glu Leu Arg Leu Gly Leu Trp Lys Thr His Gln Val Thr Asn Glu Gly 
            20                  25                  30          


Val Lys Tyr Tyr Thr Glu Trp Leu Ile Lys Leu Arg Gln Gln Asp Ile 
        35                  40                  45              


Tyr Arg Gln Ser Arg Glu Asp Ala Ser Pro Arg Val Ile Ile Ser Ala 
    50                  55                  60                  


Ser Asp Leu Lys Ala Asp Leu Leu Cys His Ala Arg Gln Leu Gln Lys 
65                  70                  75                  80  


Glu Arg Leu Pro Arg Ile Thr Gly Ser Asp Ala Glu Ile Leu Gly Thr 
                85                  90                  95      


Leu Arg Gln Val Tyr Glu Leu Ile Val Pro Ser Ser Val Gly Lys Ser 
            100                 105                 110         


Gly Asp Ser Lys Thr Leu Ala Arg Lys Phe Leu Ser Pro Leu Thr Asp 
        115                 120                 125             


Pro Gly Ser Ala Gly Gly Arg Asp Gln Ser Ala Ser Gly Arg Lys Pro 
    130                 135                 140                 


Thr Trp Met Lys Met Lys Ser Glu Gly Asn Pro Arg Trp Glu Glu Thr 
145                 150                 155                 160 


Phe Arg Lys Trp Lys Asp Arg Lys Asp Asn Asp Pro Thr Pro Leu Val 
                165                 170                 175     


Leu Asn Gln Ile Ala Asp Tyr Gly Leu Leu Pro Leu Ile Pro Leu Phe 
            180                 185                 190         


Thr Asp Val Gly Glu Asn Ile Phe Asp Pro Lys Ser Lys Ser Gln Phe 
        195                 200                 205             


Val Arg Thr Trp Asp Arg Ser Met Phe Gln Gln Ala Ile Glu Arg Leu 
    210                 215                 220                 


Met Ser Trp Glu Ser Trp Asn Gln Arg Val Arg Arg Glu Trp Glu Ala 
225                 230                 235                 240 


Leu Asn Gln Lys His Ser Ala Phe Tyr Arg Glu Gln Phe Thr Ala Asp 
                245                 250                 255     


Pro Asp Ala Ala Leu Tyr Arg Val Ala Gln Ser Leu Glu Glu Glu Met 
            260                 265                 270         


Arg Lys Glu His Gln Gly Phe Ala Ser Asp Ala Pro Glu Ala Phe Arg 
        275                 280                 285             


Ile Arg Arg Val Ala Leu Lys Gly Phe Asp Arg Leu Leu Glu Arg Trp 
    290                 295                 300                 


Gln Lys Thr Leu Gly Lys Asn Gly Gln Ser Ala Thr Leu Leu Asp Asp 
305                 310                 315                 320 


Ile Arg Arg Val Gln Ser Asp Leu Gly Asp Lys Phe Gly Ser Ala Pro 
                325                 330                 335     


Leu Tyr Gln Lys Leu Leu Asp Glu Arg Trp Gln Arg Leu Trp Ala Val 
            340                 345                 350         


Asp Pro Thr Phe Leu Gln Arg Tyr Ala Ala Phe Asn Asp Leu Thr Gln 
        355                 360                 365             


Arg Leu Gln Arg Ala Lys Arg Val Ala Asn Leu Thr Leu Pro Asp Ala 
    370                 375                 380                 


Val Ala His Pro Ile Trp Ser Arg Tyr Glu Gly Ala Asn Ala Ser Ser 
385                 390                 395                 400 


Gly Asn Arg Tyr His Ile His Leu Pro Thr Lys Gly Gln Pro Gly Ser 
                405                 410                 415     


Val Thr Phe Asp Arg Ile Leu Trp Pro Asp Gly Asn Gly Gly Trp Tyr 
            420                 425                 430         


Glu Arg Lys Arg Val Thr Val Phe Leu Arg Pro Ser His Gln Val Asp 
        435                 440                 445             


Arg Ile His Glu Ala Pro Thr Asp Ser Val Val Asp Asn Phe Pro Leu 
    450                 455                 460                 


Val Val Glu Asp Gln Ser Ala Arg Thr Ile Leu Arg Ala Ser Trp Gly 
465                 470                 475                 480 


Gly Ala Lys Leu Glu Tyr Asp Arg Asn Arg Leu Pro Arg Gln Leu Lys 
                485                 490                 495     


Lys Gly Val Pro Asp Ser Ile Tyr Leu Ser Leu Thr Leu Asn Leu Asp 
            500                 505                 510         


Thr Asn Lys Pro Ser Gly Leu Phe His Thr Gln Gln Asn Gly Arg Val 
        515                 520                 525             


Trp Ile Arg Lys Asp Val Leu Met Gln Tyr Tyr Asn Glu Thr Pro Gly 
    530                 535                 540                 


Asp Asn Val Gln Phe Lys Pro Leu Tyr Val Met Ser Val Asp Leu Gly 
545                 550                 555                 560 


Ile Arg Ser Ala Ala Ala Val Ser Ile Phe Ser Val Gln Leu Lys Ala 
                565                 570                 575     


Gly Ile Glu Glu His Arg Leu Thr Tyr Pro Val Ala Asp Cys Pro Gly 
            580                 585                 590         


Leu Val Ala Val His Glu Arg Ser Val Leu Leu Thr Met Pro Gly Glu 
        595                 600                 605             


Arg Arg Glu Gln Trp Asp Arg Arg Tyr Glu Gln Gln Arg Gln Gly Leu 
    610                 615                 620                 


Arg Glu Leu Arg Thr Asp Met Arg Gly Met Asn Asp Leu Leu Arg Gly 
625                 630                 635                 640 


Ala Tyr Met Asp Gly Asp Arg Arg Glu Glu Phe Leu Ala Arg Leu Ser 
                645                 650                 655     


Lys Leu Glu Glu Thr Ser Pro Glu Leu Trp Gly Pro Val Tyr Arg Ser 
            660                 665                 670         


Leu Asn Asp Ser Lys Val Ala Ser Ala Thr Glu Trp Glu Arg Leu Val 
        675                 680                 685             


Val Tyr Cys His Arg Gln Val Glu Gln Ser Leu Ser Ser Arg Ile Gln 
    690                 695                 700                 


Asn Leu Arg Ser Gly Arg Ser Ala Tyr Arg Met Ser Gly Gly Leu Ser 
705                 710                 715                 720 


Leu Asp His Val Gln Asp Leu Glu Arg Ile Arg Gly Ile Ile Ala Ser 
                725                 730                 735     


Trp Thr Asn His Pro Arg Ile Pro Gly Ser Val Val Arg Trp Gln Gln 
            740                 745                 750         


Gly Arg Ser His Thr Val Ala Leu Gly Arg His Ile Leu Glu Leu Lys 
        755                 760                 765             


Arg Asp Arg Val Lys Lys Val Ala Asn Tyr Leu Ile Met Thr Thr Leu 
    770                 775                 780                 


Gly Tyr Ala Tyr Asp Ser Lys Arg Ala Arg Gly Glu Lys Trp Val Arg 
785                 790                 795                 800 


Arg Tyr Pro Ala Cys His Leu Met Val Phe Glu Asp Leu Thr Arg Tyr 
                805                 810                 815     


Arg Phe Arg Thr Asp Arg Pro Arg Ser Glu Asn Arg Gln Leu Met Arg 
            820                 825                 830         


Trp Thr His Gln Glu Leu Ile Ala Val Thr Gly Ile Gln Ala Glu Pro 
        835                 840                 845             


His Gly Ile Ser Val Gly Thr Met Tyr Ala Gly Phe Ser Ser Arg Phe 
    850                 855                 860                 


Asp Ala Val Thr Lys Ala Pro Gly Val Arg Gly Ala Thr Val Arg Gln 
865                 870                 875                 880 


Ile Leu Arg Thr Arg Gly Met Val Arg Leu Lys Glu Ile Ala Ala Asp 
                885                 890                 895     


Val Gly Ile Asp Ile Asn Thr Leu Arg Pro His Asp Val Leu Pro Thr 
            900                 905                 910         


Gly Asp Gly Glu Tyr Leu Leu Ser Val Val Arg His Gly Glu Ser Tyr 
        915                 920                 925             


Arg Leu Lys Gln Val His Ala Asp Ile Asn Ala Ala His Asn Leu Gln 
    930                 935                 940                 


Arg Arg Leu Trp Thr Gln Asp Glu Val Phe Arg Val Ser Cys Arg Leu 
945                 950                 955                 960 


Ala Leu Asn Ser Gly Arg Val Val Ala Met Pro Pro Pro Ser Tyr Asn 
                965                 970                 975     


Lys Arg Tyr Gly Lys Gly Phe Phe Glu Lys Gly Asp Asn Gly Val Tyr 
            980                 985                 990         


Ile Trp Lys Thr Gly Gly Lys Ile  Lys Ile Ser Asp Thr  Leu Glu Glu 
        995                 1000                 1005             


Asp Met  Asp Ile Pro Glu Asp  Thr Ala Glu Leu Leu  Arg Gly Asn 
    1010                 1015                 1020             


Ser Val  Thr Leu Phe Arg Asp  Pro Ser Gly Thr Ile  Ala Gly Gly 
    1025                 1030                 1035             


Asn Trp  Leu Glu Ala Lys Glu  Phe Trp Gly Arg Val  Asn Ser Leu 
    1040                 1045                 1050             


Val Asn  Lys Gly Val Arg Asp  Lys Ile Leu Gly Gly  Ile Pro Val 
    1055                 1060                 1065             


Asp Asn  Ser Ser Ala His Ala  Glu 
    1070                 1075     


<210> 52
<211> 660
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12f sequence"

<400> 52
Met Pro Met Ile Lys Ile Thr Glu Cys Val Thr Trp Gly Thr Thr Cys 
1               5                   10                  15      


Asp Gly Leu Trp Asp Ala Arg Pro His Leu Glu Val Arg Arg Ser Trp 
            20                  25                  30          


Ser Pro Pro Val Gln Gly Gly Arg Thr Asn Arg Leu Asp Ala Pro Pro 
        35                  40                  45              


Ala Ser Val Thr Leu Asn Ile His Gly Arg Val Glu His Pro Arg Asp 
    50                  55                  60                  


Ala Asp Ala Leu Ser Val Ala Pro Leu Arg Val Arg His Met Phe Glu 
65                  70                  75                  80  


Arg Thr Thr Thr Lys Ala Ala Phe Leu Ser Pro Leu Asp Leu Arg Pro 
                85                  90                  95      


Thr Gln Ala Thr Asp Leu Glu Arg Phe Ala Gly Thr Thr Arg Trp Ala 
            100                 105                 110         


Phe Asn Trp Ala Asn Ala Leu Leu Glu Ala His His Gln Ala Tyr Glu 
        115                 120                 125             


Gly Arg Arg Gln Gln Ala Ala Arg His Leu Phe Gly Leu Gly Pro Glu 
    130                 135                 140                 


Gln Leu Asp Glu Leu Arg Val Leu Ala Asn Gly Thr Arg Asp Glu Asn 
145                 150                 155                 160 


Gly Lys Lys Ala Lys Gly Asp Pro Val Lys Arg Arg Glu Tyr Glu Ser 
                165                 170                 175     


Ile Gln Lys Ala Thr Lys Lys Ala Val Ser Glu Glu Asn Lys Ala Leu 
            180                 185                 190         


Gly Ala Glu Met Lys Leu Trp Asp Glu His Arg Ser Leu Val Val His 
        195                 200                 205             


Lys Gly Arg Pro Leu Leu Thr Pro Gly Asp Glu Pro Ala Leu Asp Ala 
    210                 215                 220                 


Pro Pro Leu Ala His Arg Leu Tyr Ala Arg Arg Val Glu Leu Ala Gly 
225                 230                 235                 240 


Ile Gln Lys Thr Asp Pro Asp Tyr Tyr Ala Glu Gln Arg Lys Lys Glu 
                245                 250                 255     


Arg Glu Ala Ile Thr Pro Asn Val Val Ala Met Lys Arg Asp Leu Met 
            260                 265                 270         


Ala Lys Gly Ala Tyr Phe Pro Ser Glu Tyr Asp Leu Gln Tyr Ile Trp 
        275                 280                 285             


Arg Thr Val Arg Asp Leu Pro Lys Glu Glu Gly Gly Ser Pro Trp Trp 
    290                 295                 300                 


Pro Glu Cys Pro Thr Ile Leu Phe Tyr Asp Gly Ile Asn Arg Ala Arg 
305                 310                 315                 320 


Thr Ala Trp Lys Asn Trp Met Asp Ser Ala Ser Gly Ala Arg Lys Gly 
                325                 330                 335     


Pro Pro Val Gly Met Pro Arg Phe Lys Ser Lys Tyr Lys Ala Lys Asp 
            340                 345                 350         


Thr Phe Thr Ile Thr Asn Pro Asn Arg Ser Val Ile Lys Phe Glu Thr 
        355                 360                 365             


Tyr Arg Arg Ile Ala Ile Thr Gly Ile Gly Ser Met Arg Leu His Arg 
    370                 375                 380                 


Gly Ala Lys Leu Leu Ala Arg Arg Ile Ala Ala Gly Gln Ala Glu Ile 
385                 390                 395                 400 


Thr Ser Ala Thr Ile Ser Arg Ser Gly Thr Ala Trp Tyr Val Ser Val 
                405                 410                 415     


Leu Cys Thr Val His Thr Thr Ala Arg Thr Ala Pro Ser Lys Ala Gln 
            420                 425                 430         


Arg Ser Arg Gly Ala Val Gly Val Asp Trp Gly Val Arg Ala Leu Ala 
        435                 440                 445             


Thr Thr Ser Lys Pro Ile Ala Leu Thr Pro Gly Lys Pro Ala Ser Arg 
    450                 455                 460                 


Thr Val Pro Ala Glu Lys Tyr Gly Ala Ala Met Ser Gln Lys Ile Ala 
465                 470                 475                 480 


Arg Ala Gln Arg Gln Leu Ala Arg Met Pro Lys Gly Ser Ser Arg Arg 
                485                 490                 495     


Arg Lys Ala Ala Arg His Val Ala Asp Leu Gln His Leu Val Ala Gln 
            500                 505                 510         


Arg Arg Ala Ser Ser Val His Gln Leu Ser Lys Ala Leu Ala Gln Ser 
        515                 520                 525             


Phe Glu Ile Val Ala Ile Glu Gly Leu Asn Val Arg Gly Met Thr Lys 
    530                 535                 540                 


Ser Ala Lys Gly Thr Val Glu Asn Pro Gly Lys Asn Ile Arg Gln Lys 
545                 550                 555                 560 


Ala Gly Leu Asn Arg Ala Ile Leu Asp Ala Thr Pro Gly Glu Leu Lys 
                565                 570                 575     


Arg Gln Leu Glu Tyr Lys Thr Lys Lys Tyr Gly Ser Arg Leu Val Glu 
            580                 585                 590         


Leu Asp Thr Trp Tyr Pro Ser Ser Lys Thr Cys Ser Arg Cys Gly Trp 
        595                 600                 605             


Val His Pro Lys Leu Lys Leu Ser Met Arg Thr Phe Arg Cys Gln Gln 
    610                 615                 620                 


Cys Gly Leu Val Glu Asp Arg Asp Phe Asn Ala Ala Val Asn Ile Glu 
625                 630                 635                 640 


Arg Gln Gly Ile Thr His Ile Val Lys Glu Asn Glu Gly Thr Asp Asp 
                645                 650                 655     


Arg Glu Glu Gly 
            660 


<210> 53
<211> 696
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12f sequence"

<400> 53
Met Ser Thr Pro Met Gly Trp Thr Ala Val Asn Gly Gly Asp Ala Thr 
1               5                   10                  15      


Ser Pro Thr Thr Arg Val Ser Ser Pro Pro Gly Glu Pro Arg Thr Gly 
            20                  25                  30          


Ala Cys Pro Arg Ala Ala Ala Ala Asp Ala Thr Arg Ala Glu Ser Ser 
        35                  40                  45              


Pro Arg Arg Thr Ser Ser Pro Ala Arg Pro Gly Glu Arg His Ala Arg 
    50                  55                  60                  


Ala Arg Thr Ser Arg Tyr Pro Ile Pro Asn Thr Tyr Val Val Asp Arg 
65                  70                  75                  80  


Pro Ser Ala Glu Gly Asp Arg His Gly Gln Ser Ser Leu Asp Cys Gly 
                85                  90                  95      


Pro Cys Pro Val Arg Arg Ser Gly Ala Leu His Gln Ser Ser Gln Ala 
            100                 105                 110         


Ala His Arg Arg Ser Met Thr Gly Ala Lys Gln Lys Thr Pro Ile Arg 
        115                 120                 125             


Val Val Arg Phe Ser Ile Asp His Ser Ala Leu Thr Pro Ala Gln Val 
    130                 135                 140                 


Val Ala Phe Ala Arg His Ala Gly Ala Ala Arg Gln Thr Trp Asn Trp 
145                 150                 155                 160 


Ala Leu Gly Arg Trp Met Asp Trp Arg Asn Asn Thr Lys Phe Tyr Val 
                165                 170                 175     


Asp Tyr Lys Val Phe Lys Ala Ala Gly Met Gly Pro Gly Leu Ser Thr 
            180                 185                 190         


Asp Asp Leu Ile Gln Val Ile Glu Arg Ala Val Ser Ile Arg Gln Asp 
        195                 200                 205             


Asp Lys Trp Met Asp Ala Ala Trp Asp Glu Ala Arg Gln Ile His Gly 
    210                 215                 220                 


Glu Trp Asp Gln Phe Gln Lys Ala Ser Thr Leu Gln Ser Leu Tyr Leu 
225                 230                 235                 240 


Ala Gly Ala Gln Glu Pro Phe Asp Pro Ser Arg Asp Asp Gly Ile Asn 
                245                 250                 255     


Pro Tyr His Trp Trp Val Thr Glu Gly Asp Lys Ser Gly Leu Pro Lys 
            260                 265                 270         


Ala Glu Arg His Asn Val Asn Ser Gly Ala Thr Tyr Thr Ala Pro Leu 
        275                 280                 285             


Arg Ala Phe Glu Glu Ala Val Gly Arg Phe Tyr Lys Leu Pro Gly Lys 
    290                 295                 300                 


Lys Gly Thr Pro Lys Phe Lys Ser Lys His Asp Asp Glu Gln Gly Phe 
305                 310                 315                 320 


Cys Ile Gln Arg Leu Thr Glu Thr Gly Leu Ser Pro Trp Arg Ala Ile 
                325                 330                 335     


Glu Gly Gly His Arg Ile Lys Val Pro Ser Ile Gly Ser Ile Arg Val 
            340                 345                 350         


Val Gln Ser Thr Lys Arg Leu Arg Gln Leu Ile Lys Arg Gly Gly Lys 
        355                 360                 365             


Thr Thr Ser Ala Arg Phe Thr Arg Arg Gly Gly Lys Trp Phe Val Ser 
    370                 375                 380                 


Val Ser Val Ala Phe Asp Leu Ser Ala Pro Arg Val Gln Arg Pro Ala 
385                 390                 395                 400 


Arg Leu Ser Arg Arg Gln Arg Ala Gly Gly Ser Thr Gly Val Asp Leu 
                405                 410                 415     


Gly Val Asn Arg Leu Ala Thr Leu Ser Ser Gly Asp Gln Phe Pro Asn 
            420                 425                 430         


Arg Arg Leu Leu Arg Lys Ser Met Ala Glu Ile Lys Arg Leu Gln Arg 
        435                 440                 445             


Lys Phe Asp Arg Gln His Arg Ala Gly Ser Pro Glu Cys Phe Asn Glu 
    450                 455                 460                 


Asp Gly Thr His Lys Lys Arg Cys Arg Trp Gly Arg Glu Asp Gly Pro 
465                 470                 475                 480 


Ala Met Ser Arg Ser Ala Gln Thr Thr Lys Arg Gln Leu Arg Arg Ile 
                485                 490                 495     


His Asp Leu Thr Ala Arg Arg Arg Ala Gly Val Leu His Glu Ile Thr 
            500                 505                 510         


Lys Asp Leu Ala Thr Arg Phe Glu Leu Ile Gly Val Glu Asp Leu Asn 
        515                 520                 525             


Val Ala Gly Met Thr Ala Lys Ser Lys Pro Lys Pro Asp Pro Asp Arg 
    530                 535                 540                 


Pro Gly His Phe Leu Pro Asn Arg Arg Ala Ala Lys Ala Gly Leu Asn 
545                 550                 555                 560 


Arg Ala Ile Leu Asp Val Gly Phe Tyr Glu Phe Lys Arg Gln Leu Gly 
                565                 570                 575     


Tyr Lys Thr Glu Trp Tyr Gly Ser Thr Met Gln Met Val His Arg Tyr 
            580                 585                 590         


Ala Ala Thr Ser Lys Thr Cys Ser Gly Cys Gly Trp Val Lys Pro Lys 
        595                 600                 605             


Leu Thr Leu Ala Glu Arg Thr Phe Asn Cys Thr Gln Cys Gly Leu Ala 
    610                 615                 620                 


Met Asp Arg Asp His Asn Ala Ala Val Asn Ile Arg Ala Leu Ala Leu 
625                 630                 635                 640 


Glu Gly Ala Ala Pro Met Glu Arg Glu Gln Pro Ala Pro Val Gly Ala 
                645                 650                 655     


Ala Glu Lys Arg His Arg Asp Pro Val Ser His Arg Arg Arg Pro Lys 
            660                 665                 670         


Ser Leu Ala Pro Cys Glu Ser Thr Arg Pro Val Arg Asp Leu Ser Pro 
        675                 680                 685             


Pro Ala Thr Gln Glu Glu Thr Ala 
    690                 695     


<210> 54
<211> 606
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12f sequence"

<400> 54
Met Ala Gln Ala Glu Ala Pro Arg Arg Leu Arg Ala Tyr Lys Phe Ala 
1               5                   10                  15      


Leu Asp Pro Thr Glu Ala Gln Leu Arg Glu Phe Glu Gln His Ala Gly 
            20                  25                  30          


Ser Ala Arg Trp Ala Tyr Asn His Ala Asn Ala Ile Leu Ser Arg Tyr 
        35                  40                  45              


Ser Asp Thr Leu Arg Asn Arg Trp Asn Ala Trp Ile Ala Gln His His 
    50                  55                  60                  


Gly Leu Ser Arg Glu Gln Leu Tyr Ala Leu Pro Asp Arg Glu Arg Thr 
65                  70                  75                  80  


Ala Ile Gln Ala Ala Ala Arg Ala Ala Val Lys Ala Glu Asn Ala Gln 
                85                  90                  95      


Leu Ala Ala Glu Leu Arg Ile Ile Asp Asp His Arg Lys Arg Val Thr 
            100                 105                 110         


His Lys Gly Lys Pro Ser Val Glu Pro Gly Glu Gln Pro Ala Glu Asp 
        115                 120                 125             


Ala Pro Glu Arg Ala Tyr Gln Leu Trp Arg Glu Arg Val Glu Leu Ala 
    130                 135                 140                 


Arg Leu His Ala Glu Asp Pro Gln Ala Tyr Arg Ala Glu Arg Lys Arg 
145                 150                 155                 160 


Ile Leu Asp Glu Ile Arg Pro Leu Val Asn Ala Thr Lys Arg Lys Leu 
                165                 170                 175     


Ile Glu Gln Gly Ala Tyr Arg Pro Thr Ala Met Asp Ile Ser Thr Leu 
            180                 185                 190         


Trp Arg Glu Ile Arg Asp Leu Pro Pro Asp Glu Gly Gly Ser Pro Trp 
        195                 200                 205             


Trp Pro Glu Val Ser Ile Tyr Ala Phe Thr Ser Gly Phe Ala His Ala 
    210                 215                 220                 


Glu Thr Ala Trp Lys Asn Tyr Leu Glu Ser Leu Ala Gly Arg Arg Ala 
225                 230                 235                 240 


Gly Arg Pro Val Gly Lys Pro Arg Phe Lys Lys Lys Arg Arg Ser Arg 
                245                 250                 255     


Arg Ser Phe Thr Leu Tyr Gly Ser Val Lys Leu Val Thr Tyr Arg Arg 
            260                 265                 270         


Ile Gln Val Pro Ser Ile Gly Ser Val Arg Leu His Gly Ser Ala Lys 
        275                 280                 285             


Arg Leu His Arg Ala Leu Glu Arg Arg Gly Gly Ile Ile Lys Ser Ile 
    290                 295                 300                 


Thr Ile Ser Gln Gly Gly His Arg Trp Tyr Ala Ser Val Leu Val Asp 
305                 310                 315                 320 


Glu Leu Asp Ile Thr Pro Gly Arg Glu Thr Gln Arg Gly Pro Ser Arg 
                325                 330                 335     


Arg Gln Arg Asp Arg Gly Ala Val Gly Val Asp Leu Gly Val His His 
            340                 345                 350         


Leu Val Ala Leu Ser Asp Pro Asn Glu Lys Thr Leu Asp Asn Pro Arg 
        355                 360                 365             


His Leu Arg Lys Ala Arg Lys Arg Leu Leu Lys Ala Gln Arg Ala Met 
    370                 375                 380                 


Ser Arg Arg Arg Gly Pro Asp Lys Arg Thr Gly Gln Glu Pro Ser Arg 
385                 390                 395                 400 


Arg Trp Val Lys Ala Arg Asn Arg Val Ala Arg Leu His His Glu Leu 
                405                 410                 415     


Ala Val Arg Arg Ala Gly His Leu His Glu Ile Thr Lys Arg Leu Ala 
            420                 425                 430         


Thr Ser Tyr Glu Leu Val Ala Ile Glu Asp Leu Asn Val Ala Gly Met 
        435                 440                 445             


Thr Arg Ser Ala Arg Gly Thr Ile Asp Gln Pro Gly Arg Gly Val Arg 
    450                 455                 460                 


Ala Lys Ala Gly Leu Asn Arg Ser Ile Leu Asp Thr Ser Pro Ala Glu 
465                 470                 475                 480 


Phe Arg Arg Gln Leu Gln Tyr Lys Ala Ser Trp Tyr Gly Ala Thr Val 
                485                 490                 495     


Ala Val Ile Asp Arg Trp Ala Pro Thr Ser Arg Thr Cys Ser Ser Cys 
            500                 505                 510         


Gly Ala Val Lys Ala Lys Leu Ser Leu Ala Glu Arg Thr Phe Phe Cys 
        515                 520                 525             


Glu His Cys Gly Met Glu Leu Asp Arg Asp Ile Asn Ala Ala Arg Asn 
    530                 535                 540                 


Ile Leu Ala Phe Ala Gln Ser Ala Tyr Pro Gly Glu Gly Lys Ala Leu 
545                 550                 555                 560 


Asn Ala Cys Gly Gly Ser Val Ser Pro Gly Ser Gln Ser Val Val Gln 
                565                 570                 575     


Ala Gly Ala Asp Glu Ala Gly Arg Pro Ala Arg Lys Pro Arg Arg Ser 
            580                 585                 590         


Ser Arg Gly Ser Asp Pro Pro Ala Thr Pro Thr Thr Arg Ala 
        595                 600                 605     


<210> 55
<211> 1421
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12a sequence"

<400> 55
Met Thr Ser Ser Ser Pro Thr Gln Arg Ala Tyr Thr Leu Arg Leu Lys 
1               5                   10                  15      


Ser Ala Ala Gln Gly Asp Lys Ser Trp Ala Glu Lys Leu Trp Asp Thr 
            20                  25                  30          


His Glu Ile Val Asn Lys Gly Ala Arg Ala Phe Gly Asp Trp Leu Leu 
        35                  40                  45              


Thr Leu Arg Gly Gly Ile Ser His Lys Leu Glu Asn Leu Asn Asp Lys 
    50                  55                  60                  


Glu Thr Gly Glu Glu Gly Lys Lys Arg Arg Arg Ile Leu Leu Ala Leu 
65                  70                  75                  80  


Ser Trp Leu Ser Val Glu Ser Lys Asp Phe Ala Pro Glu Lys Tyr Ile 
                85                  90                  95      


Val Glu Lys Asp Gly Glu Asp Lys His Arg Thr Lys Glu Ala Leu Glu 
            100                 105                 110         


Ala Ile Leu Lys Ser Arg Asn Leu Glu Asp Glu Glu Val Glu Ser Trp 
        115                 120                 125             


Val Asn Asp Cys Lys Asp Ser Leu Thr Ser Ser Ile Arg Asp Asp Ala 
    130                 135                 140                 


Val Trp Val Asn Arg Ser Arg Ala Phe Asp Asp Ala Val Arg Lys Ile 
145                 150                 155                 160 


Gly Asp Ser Leu Thr Arg Glu Glu Ile Trp Asp Val Leu Gly Arg Phe 
                165                 170                 175     


Phe Gly Lys Lys Glu Ala Tyr Leu Ala Pro Arg Thr Ile Asp Glu Lys 
            180                 185                 190         


Asn Gly Lys Thr Lys Lys Glu Glu Pro Lys Asp Leu Ala Arg Lys Ala 
        195                 200                 205             


Gly Gly Trp Leu Ser Lys Arg Phe Gly Lys Gly Lys Gly Thr Asp Phe 
    210                 215                 220                 


Ser Lys Leu Ser Lys Val Tyr Ser Glu Ile Val Lys Trp Ala Glu Glu 
225                 230                 235                 240 


Pro Arg Lys Ser Glu Pro Arg Thr Leu Ala Asn Leu Ala Ser Ala Leu 
                245                 250                 255     


Lys Glu Asp Ser Leu Gln Gly Ile Leu Asn Leu Ile Lys Asn Ser Gly 
            260                 265                 270         


Ser Lys Ser Gly Thr Arg Asn Phe Leu Glu Glu Ile Gly Glu Gly Glu 
        275                 280                 285             


Val Ser Lys Glu Asn Leu Ala Ile Leu Lys Ala Lys Ala Glu Gly Asn 
    290                 295                 300                 


Arg Asn Tyr Cys Lys Lys Glu Ile Gly Gly Lys Gly Arg Arg Glu Trp 
305                 310                 315                 320 


Ser Asp Arg Ile Leu Lys Ser Ile Glu Glu Thr Leu Asp Gly Lys Phe 
                325                 330                 335     


Thr Tyr Leu Gln Glu Lys Gly Pro Ala Arg His Trp Glu Phe Ala Val 
            340                 345                 350         


Met Leu Asp His Ala Ala Arg Arg Ile Ser Ala Gly His Thr Trp Ile 
        355                 360                 365             


Lys Leu Ala Glu Ala Arg Arg Arg Asn Phe Glu Glu Asp Ser Gln Lys 
    370                 375                 380                 


Ile Asn Glu Val Pro Glu Asn Ala Arg Gln Trp Leu Glu Thr Tyr Arg 
385                 390                 395                 400 


Glu Asp Arg Ser Lys Ser Ser Gly Ala Ile Glu Gly Tyr Leu Ile Ser 
                405                 410                 415     


Lys Arg Ala Val Thr Glu Trp Glu Thr Val Val Lys Ala Trp Lys Asn 
            420                 425                 430         


Cys Lys Thr Glu Glu Asp Arg Ile Ala Ala Ala Gly Ala Leu Gln Asp 
        435                 440                 445             


Asn Leu Gly Ile Asp Gln Phe Gly Asp Ile Asn Leu Phe Arg Ala Leu 
    450                 455                 460                 


Ala Ser Glu Asp Val Arg Cys Val Trp Gln Val Asp Gly Lys Pro Asp 
465                 470                 475                 480 


Ala Asn Ile Leu Leu Asn Tyr Val Ala Ala Thr Lys Ala Glu Phe Asp 
                485                 490                 495     


Lys Arg Arg Phe Lys Val Pro Ala Tyr Arg His Pro Asp Pro Leu Leu 
            500                 505                 510         


His Pro Val Phe Cys Asp Tyr Gly Asn Ser Arg Trp Glu Ile Arg Phe 
        515                 520                 525             


Asp Val His Glu Val Asn Arg Thr Gly Lys Lys Ala Lys Gln Asn Lys 
    530                 535                 540                 


Lys Thr Ile Glu Thr Ala Asp Val His Gly Leu Lys Met Asp Leu Trp 
545                 550                 555                 560 


Thr Gly Ser Lys Ile Glu Asn Val Ser Leu Arg Trp Gln Ser Lys Leu 
                565                 570                 575     


Leu Glu Lys Asp Leu Ala Val Lys Gln Leu Asp Gly Lys Glu Asp Gly 
            580                 585                 590         


Lys Lys Glu Val Ser Arg Ala Ser Arg Leu Gly Arg Ala Ala Val Gly 
        595                 600                 605             


Ala Gly Trp Glu Thr Pro Val Ser Ala Ser Ser Val Phe Ala Gln Lys 
    610                 615                 620                 


His Trp Asn Gly Arg Leu Gln Ala Ser Arg Lys Glu Leu Ser Arg Ile 
625                 630                 635                 640 


Ala Arg Arg Val Lys Thr Arg Gly Trp Asp Glu Lys Ala Asn Ser Met 
                645                 650                 655     


Lys Lys Asn Leu Lys Trp Phe Ile Thr Phe Ser Pro Lys Leu Lys Leu 
            660                 665                 670         


Gln Gly Pro Trp Ile Ser Tyr Val Asp Asn Ser Glu Asp Lys Arg Pro 
        675                 680                 685             


Phe Thr Phe Thr Ser Lys Gly Glu Pro Ile Leu Asp Glu Val Phe Ser 
    690                 695                 700                 


Ile Glu Asn Lys Asn Arg Lys Gly Arg Ala Arg Leu Ile Leu Ser Arg 
705                 710                 715                 720 


Leu Pro Gly Leu Arg Val Leu Ser Met Asp Leu Gly His Arg His Ala 
                725                 730                 735     


Ala Ala Cys Ala Val Trp Glu Thr Leu Ser Ser Arg Gln Leu Glu Asp 
            740                 745                 750         


Ala Cys Ala Glu Gly Gly Tyr Asp Lys Pro Ala Pro Asp Ala Met Tyr 
        755                 760                 765             


His His Ile Lys Ser Asn Arg Gly Lys Arg Val Ile Tyr Arg Arg Ile 
    770                 775                 780                 


Gly Ala Asp Glu Leu Ser Asp Asp Ser Ile His Pro Thr Pro Trp Ala 
785                 790                 795                 800 


Arg Leu Glu Arg Gln Phe Leu Ile Lys Leu Gln Gly Glu Glu Arg Lys 
                805                 810                 815     


Ala Arg Met Ala Thr Ala Asp Glu Ile Trp Glu Val His Glu Leu Glu 
            820                 825                 830         


Arg Ala Leu Gly Arg Lys Thr Pro Leu Val Asp Arg Leu Thr Lys Ser 
        835                 840                 845             


Gly Trp Gly Ser Asp Ser Gly Thr Pro Arg Gln Arg Gln Leu Leu Gly 
    850                 855                 860                 


Glu Leu Asn Gln Trp Gly Trp Glu Pro Asp Glu Ala Gln Glu Asn Ser 
865                 870                 875                 880 


Glu Asp Asp Glu Ile Thr Ser Arg Glu Ser Leu Leu Val Asp Lys Leu 
                885                 890                 895     


Met Ser Arg Thr Val Asp Thr Val Arg Lys Gly Leu Arg Arg His Gly 
            900                 905                 910         


Asn Arg Ala Arg Ile Ala Asn Phe Leu Val Ala Arg Glu Lys Thr Val 
        915                 920                 925             


Pro Gly Gly Gln Met Asp Thr Leu Asn Asn Glu Gly Arg Lys Glu Ile 
    930                 935                 940                 


Ile Ala Asp Ala Leu Ala Phe Trp Tyr Glu Leu Ala Asn Gly Gly Glu 
945                 950                 955                 960 


Trp Lys Asp Thr Glu Ala Leu Asp Trp Trp Lys Ile His Ile Glu Pro 
                965                 970                 975     


Glu Leu Ser Val Glu Glu Leu Pro Asp Ile Ala Gly Thr Gly Ile Ala 
            980                 985                 990         


Pro Lys Glu Arg Lys Arg Lys Lys  Lys Glu Leu Lys Glu  Lys Leu Lys 
        995                 1000                 1005             


Pro Val  Ala Glu Arg Leu Leu  Thr Ser Gly Ala Lys  Lys Leu Ser 
    1010                 1015                 1020             


Asp Gln  Trp Cys Glu Arg Trp  Lys Gln Asp Asp Lys  Glu Trp Gln 
    1025                 1030                 1035             


Lys Thr  Leu Arg Trp Leu Arg  Asp Trp Ile Leu Pro  Arg Gly Val 
    1040                 1045                 1050             


Arg Gly  Lys Ser Glu Leu Ile  Arg Asn Val Gly Gly  Leu Ser Leu 
    1055                 1060                 1065             


Asp Arg  Leu Thr Thr Ile Gln  Ser Leu Tyr Gln Ala  Gln Lys Ala 
    1070                 1075                 1080             


Tyr Phe  Thr Arg Ile Thr Pro  Lys Gly Ile Gln Met  Asp Lys Asp 
    1085                 1090                 1095             


Lys Pro  Leu Thr Ala Val Met  Asn Phe Gly Gly His  Ile Leu Asn 
    1100                 1105                 1110             


Asp Leu  Glu Asn Met Arg Glu  Gln Arg Val Lys Gln  Leu Ala Ser 
    1115                 1120                 1125             


Arg Ile  Val Glu Ala Ala Leu  Gly Val Gly Arg Val  Lys Ile Pro 
    1130                 1135                 1140             


Lys Lys  Ser Lys Asp Pro Lys  Arg His Tyr Glu Arg  Val Asp Ala 
    1145                 1150                 1155             


Pro Cys  His Ala Val Val Ile  Glu Asn Leu Thr Asn  Tyr Arg Pro 
    1160                 1165                 1170             


Glu Glu  Thr Arg Thr Arg Arg  Glu Asn Arg Gln Leu  Met Thr Trp 
    1175                 1180                 1185             


Cys Ser  Gly Lys Val Lys Lys  Tyr Leu Ser Glu Ser  Cys Ser Leu 
    1190                 1195                 1200             


His Gly  Leu Phe Leu Trp Glu  Val Pro Pro Ser Tyr  Thr Ser Arg 
    1205                 1210                 1215             


Gln Asp  Ser Arg Thr Gly Ser  Pro Gly Ile Arg Cys  Glu Glu Val 
    1220                 1225                 1230             


Ser Val  Glu Lys Phe Phe Lys  Thr Pro Phe Arg Gln  Arg Glu Val 
    1235                 1240                 1245             


Ala Arg  Ala Glu Glu Lys Asp  Ser Lys Asn Lys Ala  Ser Ala Tyr 
    1250                 1255                 1260             


Glu Gln  Tyr Leu Ile Asp Leu  Lys Glu Arg Trp Lys  Ser Arg Gly 
    1265                 1270                 1275             


Glu Glu  Thr Ala Leu Leu Arg  Ile Pro Arg Lys Gly  Gly Glu Ile 
    1280                 1285                 1290             


Phe Val  Ser Ala Asn Ser Asn  Ser Pro Ala Ser Lys  Gly Leu Gln 
    1295                 1300                 1305             


Ala Asp  Leu Asn Ala Ala Ala  Asn Ile Gly Leu Lys  Ala Ile Thr 
    1310                 1315                 1320             


Asp Pro  Asp Trp Ser Gly Ser  Trp Trp Tyr Val Pro  Cys Ser Ser 
    1325                 1330                 1335             


Lys Asp  Phe Val Pro Ile Lys  Asp Lys Ile Gly Gly  Ser Arg Ala 
    1340                 1345                 1350             


Phe Glu  Asn Ile Thr Thr Pro  Met Pro Asn Pro Asp  Asp Ala Lys 
    1355                 1360                 1365             


Glu Ala  Thr Gly Lys Lys Arg  Ser Gly Lys Lys Glu  Ile Ile Asn 
    1370                 1375                 1380             


Leu Trp  Arg Asn Pro Ala Cys  Ser Pro Leu Glu Arg  Asp Glu Trp 
    1385                 1390                 1395             


Glu Arg  Thr Ala Lys Tyr Trp  Asn Met Val Glu Tyr  His Val Ile 
    1400                 1405                 1410             


Lys Arg  Leu Lys Arg Gln Met  Gly 
    1415                 1420     


<210> 56
<211> 1333
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12a sequence"

<400> 56
Met Lys Asn Phe Gln Asp Phe Thr Asn Leu Tyr Glu Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Ile Trp Gly Thr Lys Lys Leu Ile Glu 
            20                  25                  30          


Glu Lys Asn Ile Leu Lys Leu Asp Lys Lys Lys Arg Glu Asn Tyr Glu 
        35                  40                  45              


Lys Val Lys Pro Tyr Phe Asn Lys Ile His Gln Glu Phe Ile Asn Phe 
    50                  55                  60                  


Ala Leu Arg Asn Pro Asn Phe Asp Phe Ser Gln Phe Glu Glu Lys Tyr 
65                  70                  75                  80  


Leu Asn Trp Leu Lys Asp Lys Lys Asn Lys Asp Leu Leu Lys Glu Lys 
                85                  90                  95      


Glu Ser Ile Asp Lys Ile Phe Leu Glu Lys Ile Trp Lys Leu Phe Glu 
            100                 105                 110         


Asn Ser Val Lys Asp Phe Leu Lys Glu Asn Gly Phe Glu Ser Ile Val 
        115                 120                 125             


Lys Ser Glu Asp Gln Asn Leu Lys Phe Phe Arg Arg Lys Glu Ile Phe 
    130                 135                 140                 


Glu Val Leu Gln Glu Lys Tyr Gly Ser Glu Leu Glu Thr Gln Met Val 
145                 150                 155                 160 


Asn Lys Asp Trp Glu Ile Lys Ser Ile Phe Asn Gly Trp Glu Lys Trp 
                165                 170                 175     


Leu Trp Tyr Phe Asp Lys Phe Phe Asn Thr Arg Asp Asn Phe Tyr Lys 
            180                 185                 190         


Thr Asp Trp Thr Ser Thr Ala Ile Ala Thr Arg Ile Ile Lys Asp Asn 
        195                 200                 205             


Leu Lys Ile Phe Leu Glu Asn Thr Ile Ile Phe Glu Lys Val Lys Asn 
    210                 215                 220                 


Lys Lys Ile Asp Phe Ser Glu Val Glu Lys Asn Phe Ser Val Ser Ile 
225                 230                 235                 240 


Asp Thr Phe Phe Glu Ile Asn Asn Phe Asn Asn Cys Phe Leu Gln Asp 
                245                 250                 255     


Trp Ile Asp Phe Tyr Asn Lys Val Ile Trp Gly Glu Thr Leu Glu Asn 
            260                 265                 270         


Trp Glu Lys Leu Lys Trp Leu Asn Glu Ile Ile Asn Lys Tyr Arg Gln 
        275                 280                 285             


Asp Thr Gly Glu Lys Ile Pro Tyr Phe Lys Lys Leu Gln Lys Gln Ile 
    290                 295                 300                 


Leu Ser Glu Lys Asp Trp Val Phe Ile Asp Lys Ile Glu Asp Asp Gly 
305                 310                 315                 320 


Gly Phe Tyr Glu Val Leu Lys Asn Phe Tyr Lys Asn Ala Ala Glu Lys 
                325                 330                 335     


Glu Trp Phe Leu Lys Asn Ile Phe Glu Asn Phe Tyr Thr Ile Ser Asp 
            340                 345                 350         


Lys Asn Leu Glu Lys Ile Tyr Phe Asn Lys Ile Ala Phe Asn Thr Ile 
        355                 360                 365             


Ser His Lys Phe Trp Ser Ala Leu Glu Phe Glu Arg Ile Leu Tyr Glu 
    370                 375                 380                 


Glu Met Lys Lys Glu Lys Ala Asp Trp Ile Lys Phe Glu Lys Lys Glu 
385                 390                 395                 400 


Asn Lys Tyr Lys Phe Pro Asp Phe Ile Gln Ile Ile Phe Ile Lys Arg 
                405                 410                 415     


Ser Leu Glu Asn Tyr Asp Ser Glu Asn Leu Phe Trp Lys Glu Arg Tyr 
            420                 425                 430         


Tyr Lys Ser Glu Glu Asn Val Asp Trp Phe Leu Glu Lys Asn Asn Asn 
        435                 440                 445             


Asn Ile Trp Glu Gln Phe Cys Lys Ile Leu Asn Phe Glu Phe Leu Asn 
    450                 455                 460                 


Ile Leu Lys Arg Arg Ile Ile Asp Glu Ala Trp Glu Glu Tyr Glu Val 
465                 470                 475                 480 


Trp Phe Glu Ile Ser Lys Asn Ile Leu Trp Glu Lys Leu Glu Asn Phe 
                485                 490                 495     


Glu Leu Asn Gln Glu Asn Lys Trp Ile Ile Lys Asp Phe Ala Asp Tyr 
            500                 505                 510         


Ser Leu Ala Leu Tyr Ser Phe Trp Lys Tyr Phe Ala Val Glu Lys Trp 
        515                 520                 525             


Arg Asn Trp Asp Leu Asn Ile Asp Ile Ser Asp Asp Phe Tyr Gly Trp 
    530                 535                 540                 


Glu Asp Trp Tyr Ile Glu Lys Phe Tyr Asn Thr Gly Tyr Asp Glu Ile 
545                 550                 555                 560 


Val Lys Pro Tyr Asn Leu Met Arg Asn Tyr Ile Ser Lys Lys Pro Trp 
                565                 570                 575     


Glu Asp Ser Lys Lys Trp Lys Ile Asn Phe Glu Thr Ser Ser Leu Leu 
            580                 585                 590         


Ser Trp Trp Asp Lys Asn Leu Glu Ser Asn Trp Ser Tyr Ile Phe Gln 
        595                 600                 605             


Lys Trp Asn Lys Tyr Tyr Ile Trp Ile Ile Asn Trp Ser Lys Pro Ala 
    610                 615                 620                 


Lys Glu Val Leu Glu Lys Leu Tyr Ser Trp Asn Gly Glu Lys Ile Lys 
625                 630                 635                 640 


Arg Phe Ile Tyr Asp Phe Gln Lys Pro Asp Asn Lys Asn Thr Pro Arg 
                645                 650                 655     


Met Phe Ile Arg Ser Lys Lys Asp Ser Phe Ser Pro Ala Val Gly Lys 
            660                 665                 670         


Tyr Asn Leu Pro Val Glu Asp Ile Leu Glu Ile Tyr Asp Asn Trp Leu 
        675                 680                 685             


Phe Lys Thr Glu Asn Lys Asp Asn Ser Asn Tyr Lys Glu Ser Leu Ser 
    690                 695                 700                 


Lys Leu Ile Asp Tyr Phe Lys Leu Gly Phe Ser Lys His Glu Ser Phe 
705                 710                 715                 720 


Lys His Phe Asn Phe Val Trp Lys Asp Ser Lys Glu Tyr Glu Asn Ile 
                725                 730                 735     


Ala Asp Phe Tyr Arg Asp Val Glu Lys Ser Cys Tyr Gln Ile Thr Ser 
            740                 745                 750         


Glu Phe Leu Asp Phe Glu Glu Leu Lys Lys Leu Thr Phe Lys Lys His 
        755                 760                 765             


Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Glu Leu Asp Glu Ser 
    770                 775                 780                 


Leu Gln Lys Asn Trp Tyr Asn Phe Arg Asp Glu Trp Gln Lys Asn Ile 
785                 790                 795                 800 


His Thr Lys Tyr Phe Glu Ala Leu Phe Leu Glu Glu Asn Ile Leu Arg 
                805                 810                 815     


Lys Ser Trp Ala Val Phe Lys Leu Ser Trp Gly Trp Glu Val Phe Phe 
            820                 825                 830         


Arg Lys Glu Ser Ile Lys Ala Glu Lys Glu Lys Arg Lys Asn Ile Glu 
        835                 840                 845             


Val Thr Lys Asn Arg Arg Tyr Thr Glu Glu Lys Tyr Phe Leu His Phe 
    850                 855                 860                 


Pro Ile Gln Val Asn Phe Lys Asn Glu Ile Ser Trp Asn Phe Asn Gln 
865                 870                 875                 880 


Glu Ile Asn Lys Phe Leu Ala Asn Asn Pro Asp Ile Asn Val Ile Trp 
                885                 890                 895     


Ile Asp Arg Trp Glu Lys His Leu Ala Tyr Phe Ser Val Ile Asn Gln 
            900                 905                 910         


Lys Trp Glu Ile Leu Glu Ser Trp Ser Phe Asn Lys Ile Glu Asn Tyr 
        915                 920                 925             


Asn Lys Asn Trp Glu Lys Leu Leu Phe Pro Glu Arg Glu Ile Lys Glu 
    930                 935                 940                 


Ile His Lys Asp Trp Ser Leu Ile Asp Leu Glu Leu Val Glu Thr Trp 
945                 950                 955                 960 


Arg Lys Val Asp Tyr Val Asp Tyr Lys Leu Leu Leu Glu Tyr Lys Glu 
                965                 970                 975     


Arg Lys Arg Leu Leu Gln Arg Gln Ser Trp Lys Glu Val Glu Gln Ile 
            980                 985                 990         


Lys Asp Leu Lys Lys Trp Tyr Ile  Ser Ala Leu Val Arg  Lys Ile Ala 
        995                 1000                 1005             


Asp Leu  Ile Ile Lys His Asn  Ala Ile Val Ile Phe  Glu Asp Leu 
    1010                 1015                 1020             


Asn Phe  Arg Phe Lys Gln Ile  Arg Gly Trp Ile Glu  Lys Ser Ile 
    1025                 1030                 1035             


Tyr Gln  Gln Leu Glu Lys Ala  Leu Ile Asp Lys Leu  Asn Phe Leu 
    1040                 1045                 1050             


Val Asn  Lys Asn Glu Ile Asn  Leu Glu Lys Ala Gly  Ser Ile Leu 
    1055                 1060                 1065             


Lys Ala  Tyr Gln Leu Thr Val  Pro Val Asp Ser Leu  Lys Glu Ile 
    1070                 1075                 1080             


Trp Lys  Gln Thr Trp Val Ile  Phe Tyr Thr Glu Ala  Ala Tyr Thr 
    1085                 1090                 1095             


Ser Lys  Ile Asp Pro Ile Lys  Trp Trp Arg Pro Asn  Leu Tyr Leu 
    1100                 1105                 1110             


Lys Lys  Gln Asn Ala Glu Ile  Asn Lys Glu Asn Ile  Leu Lys Phe 
    1115                 1120                 1125             


Asp Asn  Ile Ile Phe Asn Ser  Lys Glu Asn Arg Phe  Glu Phe Thr 
    1130                 1135                 1140             


Tyr Asp  Leu Lys Lys Phe Phe  Trp Lys Asp Ser Lys  Phe Pro Ala 
    1145                 1150                 1155             


Lys Thr  Val Asn Thr Val Cys  Ser Cys Val Glu Arg  Phe Lys Trp 
    1160                 1165                 1170             


Asn Arg  Asn Leu Asn Asn Asn  Lys Trp Gly Tyr Ile  His Tyr Glu 
    1175                 1180                 1185             


Asn Leu  Thr Asp Trp Lys Leu  Ala Asn Lys Glu Gln  Lys Glu Asp 
    1190                 1195                 1200             


Glu Phe  Ser Asn Phe Lys Glu  Leu Phe Glu Lys Tyr  Phe Ile Asp 
    1205                 1210                 1215             


Ile Asn  Trp Asn Ile Leu Glu  Gln Ile Lys Asn Leu  Asp Thr Lys 
    1220                 1225                 1230             


Asn Asn  Glu Lys Phe Phe Ser  Ser Phe Ile Asp Leu  Phe Thr Leu 
    1235                 1240                 1245             


Val Cys  Gln Ile Arg Asn Thr  Asn Gln Asn Ala Lys  Trp Asp Glu 
    1250                 1255                 1260             


Asn Asp  Phe Ile Leu Ser Pro  Val Glu Pro Phe Phe  Asp Ser Arg 
    1265                 1270                 1275             


Lys Ser  Gln Asn Phe Trp Lys  Ser Leu Pro Lys Asn  Trp Asp Glu 
    1280                 1285                 1290             


Asn Trp  Ala Phe Asn Ile Ala  Arg Lys Gly Leu Ile  Ile Leu Asn 
    1295                 1300                 1305             


Arg Ile  Ser Glu Asn Pro Glu  Lys Pro Asp Leu Leu  Ile Phe Asn 
    1310                 1315                 1320             


Ala Asp  Trp Asp Asn Phe Ala  Arg Asn Ile 
    1325                 1330             


<210> 57
<211> 1175
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13b sequence"

<400> 57
Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln Leu Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Glu Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Trp Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Glu Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Glu  Ser Phe Arg Glu Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  Gln Arg Glu Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Ile Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Leu 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Leu Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210> 58
<211> 1115
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13b sequence"

<400> 58
Met Glu Ser Ile Lys Asn Ser Gln Lys Ser Thr Gly Lys Thr Leu Gln 
1               5                   10                  15      


Lys Asp Pro Pro Tyr Phe Gly Leu Tyr Leu Asn Met Ala Leu Leu Asn 
            20                  25                  30          


Val Arg Lys Val Glu Asn His Ile Arg Lys Trp Leu Gly Asp Val Ala 
        35                  40                  45              


Leu Leu Pro Glu Lys Ser Gly Phe His Ser Leu Leu Thr Thr Asp Asn 
    50                  55                  60                  


Leu Ser Ser Ala Lys Trp Thr Arg Phe Tyr Tyr Lys Ser Arg Lys Phe 
65                  70                  75                  80  


Leu Pro Phe Leu Glu Met Phe Asp Ser Asp Lys Lys Ser Tyr Glu Asn 
                85                  90                  95      


Arg Arg Glu Thr Thr Glu Cys Leu Asp Thr Ile Asp Arg Gln Lys Ile 
            100                 105                 110         


Ser Ser Leu Leu Lys Glu Val Tyr Gly Lys Leu Gln Asp Ile Arg Asn 
        115                 120                 125             


Ala Phe Ser His Tyr His Ile Asp Asp Gln Ser Val Lys His Thr Ala 
    130                 135                 140                 


Leu Ile Ile Ser Ser Glu Met His Arg Phe Ile Glu Asn Ala Tyr Ser 
145                 150                 155                 160 


Phe Ala Leu Gln Lys Thr Arg Ala Arg Phe Thr Gly Val Phe Val Glu 
                165                 170                 175     


Thr Asp Phe Leu Gln Ala Glu Glu Lys Gly Asp Asn Lys Lys Phe Phe 
            180                 185                 190         


Ala Ile Gly Gly Asn Glu Gly Ile Lys Leu Lys Asp Asn Ala Leu Ile 
        195                 200                 205             


Phe Leu Ile Cys Leu Phe Leu Asp Arg Glu Glu Ala Phe Lys Phe Leu 
    210                 215                 220                 


Ser Arg Ala Thr Gly Phe Lys Ser Thr Lys Glu Lys Gly Phe Leu Ala 
225                 230                 235                 240 


Val Arg Glu Thr Phe Cys Ala Leu Cys Cys Arg Gln Pro His Glu Arg 
                245                 250                 255     


Leu Leu Ser Val Asn Pro Arg Glu Ala Leu Leu Met Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Asn Arg Cys Pro Asp Ile Leu Phe Glu Met Leu Asp Glu Lys 
        275                 280                 285             


Asp Gln Lys Ser Phe Leu Pro Leu Leu Gly Glu Glu Glu Gln Ala His 
    290                 295                 300                 


Ile Leu Glu Asn Ser Leu Asn Asp Glu Leu Cys Glu Ala Ile Asp Asp 
305                 310                 315                 320 


Pro Phe Glu Met Ile Ala Ser Leu Ser Lys Arg Val Arg Tyr Lys Asn 
                325                 330                 335     


Arg Phe Pro Tyr Leu Met Leu Arg Tyr Ile Glu Glu Lys Asn Leu Leu 
            340                 345                 350         


Pro Phe Ile Arg Phe Arg Ile Asp Leu Gly Cys Leu Glu Leu Ala Ser 
        355                 360                 365             


Tyr Pro Lys Lys Met Gly Glu Glu Asn Asn Tyr Glu Arg Ser Val Thr 
    370                 375                 380                 


Asp His Ala Met Ala Phe Gly Arg Leu Thr Asp Phe His Asn Glu Asp 
385                 390                 395                 400 


Ala Val Leu Gln Gln Ile Thr Lys Gly Ile Thr Asp Glu Val Arg Phe 
                405                 410                 415     


Ser Leu Tyr Ala Pro Arg Tyr Ala Ile Tyr Asn Asn Lys Ile Gly Phe 
            420                 425                 430         


Val Arg Thr Gly Gly Ser Asp Lys Ile Ser Phe Pro Thr Leu Lys Lys 
        435                 440                 445             


Lys Gly Gly Glu Gly His Cys Val Ala Tyr Thr Leu Gln Asn Thr Lys 
    450                 455                 460                 


Ser Phe Gly Phe Ile Ser Ile Tyr Asp Leu Arg Lys Ile Leu Leu Leu 
465                 470                 475                 480 


Ser Phe Leu Asp Lys Asp Lys Ala Lys Asn Ile Val Ser Gly Leu Leu 
                485                 490                 495     


Glu Gln Cys Glu Lys His Trp Lys Asp Leu Ser Glu Asn Leu Phe Asp 
            500                 505                 510         


Ala Ile Arg Thr Glu Leu Gln Lys Glu Phe Pro Val Pro Leu Ile Arg 
        515                 520                 525             


Tyr Thr Leu Pro Arg Ser Lys Gly Gly Lys Leu Val Ser Ser Lys Leu 
    530                 535                 540                 


Ala Asp Lys Gln Glu Lys Tyr Glu Ser Glu Phe Glu Arg Arg Lys Glu 
545                 550                 555                 560 


Lys Leu Thr Glu Ile Leu Ser Glu Lys Asp Phe Asp Leu Ser Gln Ile 
                565                 570                 575     


Pro Arg Arg Met Ile Asp Glu Trp Leu Asn Val Leu Pro Thr Ser Arg 
            580                 585                 590         


Glu Lys Lys Leu Lys Gly Tyr Val Glu Thr Leu Lys Leu Asp Cys Arg 
        595                 600                 605             


Glu Arg Leu Arg Val Phe Glu Lys Arg Glu Lys Gly Glu His Pro Val 
    610                 615                 620                 


Pro Pro Arg Ile Gly Glu Met Ala Thr Asp Leu Ala Lys Asp Ile Ile 
625                 630                 635                 640 


Arg Met Val Ile Asp Gln Gly Val Lys Gln Arg Ile Thr Ser Ala Tyr 
                645                 650                 655     


Tyr Ser Glu Ile Gln Arg Cys Leu Ala Gln Tyr Ala Gly Asp Asp Asn 
            660                 665                 670         


Arg Arg His Leu Asp Ser Ile Ile Arg Glu Leu Arg Leu Lys Asp Thr 
        675                 680                 685             


Lys Asn Gly His Pro Phe Leu Gly Lys Val Leu Arg Pro Gly Leu Gly 
    690                 695                 700                 


His Thr Glu Lys Leu Tyr Gln Arg Tyr Phe Glu Glu Lys Lys Glu Trp 
705                 710                 715                 720 


Leu Glu Ala Thr Phe Tyr Pro Ala Ala Ser Pro Lys Arg Val Pro Arg 
                725                 730                 735     


Phe Val Asn Pro Pro Thr Gly Lys Gln Lys Glu Leu Pro Leu Ile Ile 
            740                 745                 750         


Arg Asn Leu Met Lys Glu Arg Pro Glu Trp Arg Asp Trp Lys Gln Arg 
        755                 760                 765             


Lys Asn Ser His Pro Ile Asp Leu Pro Ser Gln Leu Phe Glu Asn Glu 
    770                 775                 780                 


Ile Cys Arg Leu Leu Lys Asp Lys Ile Gly Lys Glu Pro Ser Gly Lys 
785                 790                 795                 800 


Leu Lys Trp Asn Glu Met Phe Lys Leu Tyr Trp Asp Lys Glu Phe Pro 
                805                 810                 815     


Asn Gly Met Gln Arg Phe Tyr Arg Cys Lys Arg Arg Val Glu Val Phe 
            820                 825                 830         


Asp Lys Val Val Glu Tyr Glu Tyr Ser Glu Glu Gly Gly Asn Tyr Lys 
        835                 840                 845             


Lys Tyr Tyr Glu Ala Leu Ile Asp Glu Val Val Arg Gln Lys Ile Ser 
    850                 855                 860                 


Ser Ser Lys Glu Lys Ser Lys Leu Gln Val Glu Asp Leu Thr Leu Ser 
865                 870                 875                 880 


Val Arg Arg Val Phe Lys Arg Ala Ile Asn Glu Lys Glu Tyr Gln Leu 
                885                 890                 895     


Arg Leu Leu Cys Glu Asp Asp Arg Leu Leu Phe Met Ala Val Arg Asp 
            900                 905                 910         


Leu Tyr Asp Trp Lys Glu Ala Gln Leu Asp Leu Asp Lys Ile Asp Asn 
        915                 920                 925             


Met Leu Gly Glu Pro Val Ser Val Ser Gln Val Ile Gln Leu Glu Gly 
    930                 935                 940                 


Gly Gln Pro Asp Ala Val Ile Lys Ala Glu Cys Lys Leu Lys Asp Val 
945                 950                 955                 960 


Ser Lys Leu Met Arg Tyr Cys Tyr Asp Gly Arg Val Lys Gly Leu Met 
                965                 970                 975     


Pro Tyr Phe Ala Asn His Glu Ala Thr Gln Glu Gln Val Glu Met Glu 
            980                 985                 990         


Leu Arg His Tyr Glu Asp His Arg  Arg Arg Val Phe Asn  Trp Val Phe 
        995                 1000                 1005             


Ala Leu  Glu Lys Ser Val Leu  Lys Asn Glu Lys Leu  Arg Arg Phe 
    1010                 1015                 1020             


Tyr Glu  Glu Ser Gln Gly Gly  Cys Glu His Arg Arg  Cys Ile Asp 
    1025                 1030                 1035             


Ala Leu  Arg Lys Ala Ser Leu  Val Ser Glu Glu Glu  Tyr Glu Phe 
    1040                 1045                 1050             


Leu Val  His Ile Arg Asn Lys  Ser Ala His Asn Gln  Phe Pro Asp 
    1055                 1060                 1065             


Leu Glu  Ile Gly Lys Leu Pro  Pro Asn Val Thr Ser  Gly Phe Cys 
    1070                 1075                 1080             


Glu Cys  Ile Trp Ser Lys Tyr  Lys Ala Ile Ile Cys  Arg Ile Ile 
    1085                 1090                 1095             


Pro Phe  Ile Asp Pro Glu Arg  Arg Phe Phe Gly Lys  Leu Leu Glu 
    1100                 1105                 1110             


Gln Lys  
    1115 


<210> 59
<211> 1115
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13b sequence"

<400> 59
Met Glu Ser Ile Lys Asn Ser Gln Lys Ser Thr Gly Lys Thr Leu Gln 
1               5                   10                  15      


Lys Asp Pro Pro Tyr Phe Gly Leu Tyr Leu Asn Met Ala Leu Leu Asn 
            20                  25                  30          


Val Arg Lys Val Glu Asn His Ile Arg Lys Trp Leu Gly Asp Val Ala 
        35                  40                  45              


Leu Leu Pro Glu Lys Ser Gly Phe His Ser Leu Leu Thr Thr Asp Asn 
    50                  55                  60                  


Leu Ser Ser Ala Lys Trp Thr Arg Phe Tyr Tyr Lys Ser Arg Lys Phe 
65                  70                  75                  80  


Leu Pro Phe Leu Glu Met Phe Asp Ser Asp Lys Lys Ser Tyr Glu Asn 
                85                  90                  95      


Arg Arg Glu Thr Ala Glu Cys Leu Asp Thr Ile Asp Arg Gln Lys Ile 
            100                 105                 110         


Ser Ser Leu Leu Lys Glu Val Tyr Gly Lys Leu Gln Asp Ile Arg Asn 
        115                 120                 125             


Ala Phe Ser His Tyr His Ile Asp Asp Gln Ser Val Lys His Thr Ala 
    130                 135                 140                 


Leu Ile Ile Ser Ser Glu Met His Arg Phe Ile Glu Asn Ala Tyr Ser 
145                 150                 155                 160 


Phe Ala Leu Gln Lys Thr Arg Ala Arg Phe Thr Gly Val Phe Val Glu 
                165                 170                 175     


Thr Asp Phe Leu Gln Ala Glu Glu Lys Gly Asp Asn Lys Lys Phe Phe 
            180                 185                 190         


Ala Ile Gly Gly Asn Glu Gly Ile Lys Leu Lys Asp Asn Ala Leu Ile 
        195                 200                 205             


Phe Leu Ile Cys Leu Phe Leu Asp Arg Glu Glu Ala Phe Lys Phe Leu 
    210                 215                 220                 


Ser Arg Ala Thr Gly Phe Lys Ser Thr Lys Glu Lys Gly Phe Leu Ala 
225                 230                 235                 240 


Val Arg Glu Thr Phe Cys Ala Leu Cys Cys Arg Gln Pro His Glu Arg 
                245                 250                 255     


Leu Leu Ser Val Asn Pro Arg Glu Ala Leu Leu Met Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Asn Arg Cys Pro Asp Ile Leu Phe Glu Met Leu Asp Glu Lys 
        275                 280                 285             


Asp Gln Lys Ser Phe Leu Pro Leu Leu Gly Glu Glu Glu Gln Ala His 
    290                 295                 300                 


Ile Leu Glu Asn Ser Leu Asn Asp Glu Leu Cys Glu Ala Ile Asp Asp 
305                 310                 315                 320 


Pro Phe Glu Met Ile Ala Ser Leu Ser Lys Arg Val Arg Tyr Lys Asn 
                325                 330                 335     


Arg Phe Pro Tyr Leu Met Leu Arg Tyr Ile Glu Glu Lys Asn Leu Leu 
            340                 345                 350         


Pro Phe Ile Arg Phe Arg Ile Asp Leu Gly Cys Leu Glu Leu Ala Ser 
        355                 360                 365             


Tyr Pro Lys Lys Met Gly Glu Glu Asn Asn Tyr Glu Arg Ser Val Thr 
    370                 375                 380                 


Asp His Ala Met Ala Phe Gly Arg Leu Thr Asp Phe His Asn Glu Asp 
385                 390                 395                 400 


Ala Val Leu Gln Gln Ile Thr Lys Gly Ile Thr Asp Glu Val Arg Phe 
                405                 410                 415     


Ser Leu Tyr Ala Pro Arg Tyr Ala Ile Tyr Asn Asn Lys Ile Gly Phe 
            420                 425                 430         


Val Arg Thr Ser Gly Ser Asp Lys Ile Ser Phe Pro Thr Leu Lys Lys 
        435                 440                 445             


Lys Gly Gly Glu Gly His Cys Val Ala Tyr Thr Leu Gln Asn Thr Lys 
    450                 455                 460                 


Ser Phe Gly Phe Ile Ser Ile Tyr Asp Leu Arg Lys Ile Leu Leu Leu 
465                 470                 475                 480 


Ser Phe Leu Asp Lys Asp Lys Ala Lys Asn Ile Val Ser Gly Leu Leu 
                485                 490                 495     


Glu Gln Cys Glu Lys His Trp Lys Asp Leu Ser Glu Asn Leu Phe Asp 
            500                 505                 510         


Ala Ile Arg Thr Glu Leu Gln Lys Glu Phe Pro Val Pro Leu Ile Arg 
        515                 520                 525             


Tyr Thr Leu Pro Arg Ser Lys Gly Gly Lys Leu Val Ser Ser Lys Leu 
    530                 535                 540                 


Ala Asp Lys Gln Glu Lys Tyr Glu Ser Glu Phe Glu Arg Arg Lys Glu 
545                 550                 555                 560 


Lys Leu Thr Glu Ile Leu Ser Glu Lys Asp Phe Asp Leu Ser Gln Ile 
                565                 570                 575     


Pro Arg Arg Met Ile Asp Glu Trp Leu Asn Val Leu Pro Thr Ser Arg 
            580                 585                 590         


Glu Lys Lys Leu Lys Gly Tyr Val Glu Thr Leu Lys Leu Asp Cys Arg 
        595                 600                 605             


Glu Arg Leu Arg Val Phe Glu Lys Arg Glu Lys Gly Glu His Pro Leu 
    610                 615                 620                 


Pro Pro Arg Ile Gly Glu Met Ala Thr Asp Leu Ala Lys Asp Ile Ile 
625                 630                 635                 640 


Arg Met Val Ile Asp Gln Gly Val Lys Gln Arg Ile Thr Ser Ala Tyr 
                645                 650                 655     


Tyr Ser Glu Ile Gln Arg Cys Leu Ala Gln Tyr Ala Gly Asp Asp Asn 
            660                 665                 670         


Arg Arg His Leu Asp Ser Ile Ile Arg Glu Leu Arg Leu Lys Asp Thr 
        675                 680                 685             


Lys Asn Gly His Pro Phe Leu Gly Lys Val Leu Arg Pro Gly Leu Gly 
    690                 695                 700                 


His Thr Glu Lys Leu Tyr Gln Arg Tyr Phe Glu Glu Lys Lys Glu Trp 
705                 710                 715                 720 


Leu Glu Ala Thr Phe Tyr Pro Ala Ala Ser Pro Lys Arg Val Pro Arg 
                725                 730                 735     


Phe Val Asn Pro Pro Thr Gly Lys Gln Lys Glu Leu Pro Leu Ile Ile 
            740                 745                 750         


Arg Asn Leu Met Lys Glu Arg Pro Glu Trp Arg Asp Trp Lys Gln Arg 
        755                 760                 765             


Lys Asn Ser His Pro Ile Asp Leu Pro Ser Gln Leu Phe Glu Asn Glu 
    770                 775                 780                 


Ile Cys Arg Leu Leu Lys Asp Lys Ile Gly Lys Glu Pro Ser Gly Lys 
785                 790                 795                 800 


Leu Lys Trp Asn Glu Met Phe Lys Leu Tyr Trp Asp Lys Glu Phe Pro 
                805                 810                 815     


Asn Gly Met Gln Arg Phe Tyr Arg Cys Lys Arg Arg Val Glu Val Phe 
            820                 825                 830         


Asp Lys Val Val Glu Tyr Glu Tyr Ser Glu Glu Gly Gly Asn Tyr Lys 
        835                 840                 845             


Lys Tyr Tyr Glu Ala Leu Ile Asp Glu Val Val Arg Gln Lys Ile Ser 
    850                 855                 860                 


Ser Ser Lys Glu Lys Ser Lys Leu Gln Val Glu Asp Leu Thr Leu Ser 
865                 870                 875                 880 


Val Arg Arg Val Phe Lys Arg Ala Ile Asn Glu Lys Glu Tyr Gln Leu 
                885                 890                 895     


Arg Leu Leu Cys Glu Asp Asp Arg Leu Leu Phe Met Ala Val Arg Asp 
            900                 905                 910         


Leu Tyr Asp Trp Lys Glu Ala Gln Leu Asp Leu Asp Lys Ile Asp Asn 
        915                 920                 925             


Met Leu Gly Glu Pro Val Ser Val Ser Gln Val Ile Gln Leu Glu Gly 
    930                 935                 940                 


Gly Gln Pro Asp Ala Val Ile Lys Ala Glu Cys Lys Leu Lys Asp Val 
945                 950                 955                 960 


Ser Lys Leu Met Arg Tyr Cys Tyr Asp Gly Arg Val Lys Gly Leu Met 
                965                 970                 975     


Pro Tyr Phe Ala Asn His Glu Ala Thr Gln Glu Gln Val Glu Met Glu 
            980                 985                 990         


Leu Arg His Tyr Glu Asp His Arg  Arg Arg Val Phe Asn  Trp Val Phe 
        995                 1000                 1005             


Ala Leu  Glu Lys Ser Val Leu  Lys Asn Glu Lys Leu  Arg Arg Phe 
    1010                 1015                 1020             


Tyr Glu  Glu Ser Gln Gly Gly  Cys Glu His Arg Arg  Cys Ile Asp 
    1025                 1030                 1035             


Ala Leu  Arg Lys Ala Ser Leu  Val Ser Glu Glu Glu  Tyr Glu Phe 
    1040                 1045                 1050             


Leu Val  His Ile Arg Asn Lys  Ser Ala His Asn Gln  Phe Pro Asp 
    1055                 1060                 1065             


Leu Glu  Ile Gly Lys Leu Pro  Pro Asn Val Thr Ser  Gly Phe Cys 
    1070                 1075                 1080             


Glu Cys  Ile Trp Ser Lys Tyr  Lys Ala Ile Ile Cys  Arg Ile Ile 
    1085                 1090                 1095             


Pro Phe  Ile Asp Pro Glu Arg  Arg Phe Phe Gly Lys  Leu Leu Glu 
    1100                 1105                 1110             


Gln Lys  
    1115 


<210> 60
<211> 1008
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13b sequence"

<400> 60
Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210> 61
<211> 1063
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13b sequence"

<400> 61
Met Phe Asp Asn Glu Gln Lys Asn Leu Glu Lys Glu Pro Tyr Trp Gly 
1               5                   10                  15      


Val Phe Leu Asn Gln Ala Arg Leu Asn Ala Tyr Ile Ala Leu Arg Asp 
            20                  25                  30          


Ile Ser Glu Arg Leu Glu Glu Asn Ala Ala Asp Glu Asp Ser Leu Ser 
        35                  40                  45              


Glu Trp Pro Val Leu Lys Tyr Leu Asp Asn Asp Thr Asp Ala Val Lys 
    50                  55                  60                  


Ser Arg Arg Ile Phe Asp Leu Val Glu Lys His Phe Ser Met Leu Lys 
65                  70                  75                  80  


Ile Ile Tyr Gly Gly Glu Lys Glu Gly Asp Leu Val Lys Arg Ser Lys 
                85                  90                  95      


Glu Tyr Lys Ile Ile Leu Lys Cys Leu Phe Arg Ala Leu Asn Phe Tyr 
            100                 105                 110         


Arg Asn Lys Phe Cys His Met Tyr Ser Gly Asn Arg Ala Arg Lys Tyr 
        115                 120                 125             


Asn Glu Lys Glu Leu Ile Lys Tyr Leu Glu Asp Cys Phe Asp Ala Ser 
    130                 135                 140                 


Val Arg Lys Ile Lys Glu Leu Arg Arg Leu Asp Glu Lys Asp Val Leu 
145                 150                 155                 160 


His Leu Arg Arg Lys Ile Ala Glu Gly Lys Asp Ala Asn Lys Arg Val 
                165                 170                 175     


Ile Asp Asn Pro Gln Phe Arg Tyr Pro Phe Lys Asn Glu Lys Gly Glu 
            180                 185                 190         


Leu Asn Glu Lys Gly Leu Tyr Phe Leu Ala Ser Ile Phe Leu Asp Lys 
        195                 200                 205             


Lys Glu Ala His Glu Phe Leu Lys Lys Gln Glu Tyr Phe Lys Asn Asp 
    210                 215                 220                 


Ser Glu Pro Lys Tyr Arg Ala Thr Leu Glu Ser Phe Tyr His Tyr Arg 
225                 230                 235                 240 


Ile Lys Leu Pro Arg Pro Val Ile Glu Ser Asp Val Asp Lys Asn Gly 
                245                 250                 255     


Leu Ala Leu Asp Met Leu Asn Glu Leu Lys Lys Cys Pro Lys Glu Leu 
            260                 265                 270         


Phe Asp Leu Leu Ser Lys Glu Gln Gln Glu Lys Phe Arg Val Val Asp 
        275                 280                 285             


Ser Glu Asp Ala Asp Glu Glu Gly Asn Glu Ile Leu Met Arg Arg Tyr 
    290                 295                 300                 


Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Tyr Cys Asp Glu Asn Gln 
305                 310                 315                 320 


Val Phe Glu Arg Ile Arg Phe Gln Ile Asp Leu Gly Arg Tyr Tyr Phe 
                325                 330                 335     


Lys Phe Tyr Pro Lys Glu Thr Ile Asp Gly Lys Thr Gln Gln Arg Ser 
            340                 345                 350         


Leu Asp Lys Arg Leu Lys Ile Phe Gly Arg Ile Lys Asp Val Lys Ser 
        355                 360                 365             


Lys Val Glu Gln Glu Trp Ser Gly Ile Ile Lys Ser Pro Asp Thr Ile 
    370                 375                 380                 


Glu Glu Asn Pro Asn Glu Pro Tyr Lys Leu Lys Thr Thr Pro Arg Tyr 
385                 390                 395                 400 


Asn Ile Val Asp Asn Gln Ile Gly Phe Val Ile Thr Gly Asp Lys Asn 
                405                 410                 415     


Leu Pro Asp Val Lys Arg Pro Asp Gly Arg Ile Glu Leu Glu Lys Pro 
            420                 425                 430         


Asp Gly Trp Leu Ser Ile Tyr Glu Leu Pro Gly Met Leu Phe His Gly 
        435                 440                 445             


Leu Lys Tyr Gly Phe Asp Lys Thr Glu Arg Met Ile Lys Ile Tyr Ile 
    450                 455                 460                 


Glu Lys Gln Arg Lys Ile Cys Lys Glu Ile Cys Glu Lys Gly Thr Ile 
465                 470                 475                 480 


Thr Pro Asp Asp Gly Glu Ser Met Pro Glu Ala Leu Lys Gly Gly Ala 
                485                 490                 495     


Lys Ala Ala Lys Arg Asn Tyr Ser Glu Lys Lys Leu Glu Arg Met Leu 
            500                 505                 510         


Gln Asp Thr Glu Gln Arg Ile Arg Ala Ile Gln Thr Thr Gln Lys Arg 
        515                 520                 525             


Met Asp Glu Pro Gly Asn Lys Pro Gly Lys Lys Lys Phe Phe Asp Ile 
    530                 535                 540                 


Arg Ala Gly Lys Leu Ala Asp Phe Leu Ala Arg Asp Ile Met Ala Leu 
545                 550                 555                 560 


Gln Arg Phe Asp Pro Ala Lys His Gly Lys Asp Lys Leu Thr Ala Ile 
                565                 570                 575     


Asn Phe Gln Val Leu Gln Ala Thr Leu Ala Phe Tyr Gly Ala Lys Lys 
            580                 585                 590         


Asp Val Ile Glu Asp Met Phe Lys Gly Ile Gly Leu Leu Glu Gly Asp 
        595                 600                 605             


Asn Pro His Pro Phe Leu Asn Gln Ile Asp Pro Ala Gln Tyr Asn Ser 
    610                 615                 620                 


Ile Ala Gly Phe Tyr Gln Ala Tyr Leu Gln Lys Lys Arg Ser Tyr Leu 
625                 630                 635                 640 


Glu Asp Tyr Arg Lys Glu Glu Glu Tyr Asp Glu Gln Phe Leu Arg Pro 
                645                 650                 655     


Lys Arg Gln Arg Tyr Ala Gln Glu Lys Arg Glu Ile Lys Thr Val Ala 
            660                 665                 670         


Arg Gln Leu Leu Asp Asn Pro Val Asn Val Pro Lys Asn Phe Phe Lys 
        675                 680                 685             


Lys Glu Ile Glu Glu Phe Val Phe Ser Gln Asp Pro Ser Leu Lys Lys 
    690                 695                 700                 


Ser Lys Met Asn Thr Ala Tyr Met Ile Gln Ala Leu Phe Glu Lys His 
705                 710                 715                 720 


Tyr Gly Arg Gln Gln Pro Phe Tyr Ser Tyr Asn Arg Thr Tyr Pro Val 
                725                 730                 735     


Val Ser Lys Ala Ile Glu Tyr Gly Lys Lys Gly Lys Asn Lys Lys Ile 
            740                 745                 750         


Ala Lys Val Leu Met Ala Ile Glu Pro Lys Leu Asn Tyr Met Glu Ile 
        755                 760                 765             


Lys Lys Ile Val Asn Glu Met Pro Asp Gly Gln Tyr Glu Pro Glu Asn 
    770                 775                 780                 


Leu Lys Arg Asn Leu Tyr Glu Gly Tyr Lys Asp Tyr Glu Lys Asp Glu 
785                 790                 795                 800 


Arg Ile Ile Arg Arg Cys Lys Val Gln Asp Val Val Ser Phe Met Met 
                805                 810                 815     


Val Glu Glu Thr Leu Lys Asp Gln Leu Asp Phe Asn Gly Asn Val Leu 
            820                 825                 830         


Thr Leu Glu Lys Ile Thr Pro Trp Glu Ala Ser Pro Phe Lys Lys Pro 
        835                 840                 845             


Val Leu Cys His Thr Ile Ile Ser Ile Pro Phe Asn Thr Lys Gly Gly 
    850                 855                 860                 


His Thr Asp Lys Asp Tyr Val Asp Phe Ile Lys Asn Asn Phe Glu Gly 
865                 870                 875                 880 


Ser Tyr Asp Cys Glu Pro Asn Lys Ile Ile Leu Lys Tyr Lys Val Thr 
                885                 890                 895     


Ser Lys Asp Thr Lys Leu Lys Asp Ile Gly Lys Tyr Arg Met Tyr Ser 
            900                 905                 910         


His Asp Arg Arg Leu Pro Gly Leu Leu Ile Trp Lys Tyr Arg Pro Asn 
        915                 920                 925             


Asp Gln Asn Gly Asn Glu Ile Lys Phe Thr Glu Ile Glu Gln Glu Ile 
    930                 935                 940                 


Lys Ala Phe Glu Arg Arg Arg Ile Glu Ile Ala Gln Cys Leu Tyr Thr 
945                 950                 955                 960 


Leu Glu Lys Lys Val Ile Asp Ser Trp Phe Thr Gln Asp Glu Leu Gly 
                965                 970                 975     


Glu Glu His Ile Pro Phe Asn Lys Val Ile Asp Val Ile Lys Ala Lys 
            980                 985                 990         


Met Pro Asn Phe Glu Asp Lys Cys  Asn Val Leu Leu Lys  Ile Arg Asn 
        995                 1000                 1005             


Ala Ile  Asn His Asn Gln Phe  Pro Val Tyr Glu Gln  Ala Ile Gln 
    1010                 1015                 1020             


Thr Ala  Pro Gly Lys Glu Ile  Ala Gly Lys Met Leu  Arg Ile Thr 
    1025                 1030                 1035             


Glu Ser  Tyr Ile Glu Gln Ile  Met Ala Lys Ile Asp  Pro Asp Phe 
    1040                 1045                 1050             


Gly Arg  Thr Glu Asp Ala Glu  Ser Ser Arg 
    1055                 1060             


<210> 62
<211> 1009
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13b sequence"


<220>
<221> MOD_RES
<222> (375)..(375)
<223> Any amino acid

<400> 62
Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Xaa Pro Gln Tyr Arg Ile Val Gly Asn Arg 
    370                 375                 380                 


Ile Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro 
385                 390                 395                 400 


Asp Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu 
                405                 410                 415     


Phe Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr 
            420                 425                 430         


Gly Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn 
        435                 440                 445             


Asn Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp 
    450                 455                 460                 


Phe Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr 
465                 470                 475                 480 


Ala Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys 
                485                 490                 495     


Gly Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys 
            500                 505                 510         


Gln Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile 
        515                 520                 525             


Lys Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys 
    530                 535                 540                 


Met Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe 
545                 550                 555                 560 


Leu Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser 
                565                 570                 575     


Leu Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn 
            580                 585                 590         


Arg Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys 
        595                 600                 605             


Gly Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys 
    610                 615                 620                 


Gln Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys 
625                 630                 635                 640 


Trp Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu 
                645                 650                 655     


Glu Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys 
            660                 665                 670         


Arg Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg 
        675                 680                 685             


Gly Ile Phe Asn Glu Pro Ile Ala Lys Ala Val Gln Lys Ala Gly Val 
    690                 695                 700                 


Lys Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser 
705                 710                 715                 720 


Asn Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys 
                725                 730                 735     


Gly Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu 
            740                 745                 750         


Leu Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr 
        755                 760                 765             


Glu Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr 
    770                 775                 780                 


Glu Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile 
785                 790                 795                 800 


Met Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp 
                805                 810                 815     


Leu Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro 
            820                 825                 830         


Tyr Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu 
        835                 840                 845             


Pro Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg 
    850                 855                 860                 


Leu Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg 
865                 870                 875                 880 


Glu Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn 
                885                 890                 895     


Leu Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His 
            900                 905                 910         


Arg His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn 
        915                 920                 925             


His Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala 
    930                 935                 940                 


Glu Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys 
945                 950                 955                 960 


Met Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile 
                965                 970                 975     


Ala Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile 
            980                 985                 990         


Gly Glu Ile Tyr Glu Arg Met Thr  Thr Glu Ile Glu Lys  Gln Met Gln 
        995                 1000                 1005             


Val 
    


<210> 63
<211> 1160
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13b sequence"

<400> 63
Met Lys Thr Leu Gly Ala Leu Ser Ser His Asn Tyr Asn Asn Lys Lys 
1               5                   10                  15      


Tyr Tyr Phe Ser Gly Leu Leu Asn Thr Ala Gln Tyr Asn Phe Asn Leu 
            20                  25                  30          


Ala Leu Gln Glu Val Asn Asp Arg Leu Gly Lys Lys Gly Lys Asn Pro 
        35                  40                  45              


Gly Lys Thr Met Ile Lys Asn Ile Phe Asp Gln Lys Asp Ser Phe Ser 
    50                  55                  60                  


Thr Gln Glu Arg Ala Met Tyr Tyr Leu Glu Glu Phe Phe Pro Trp Ile 
65                  70                  75                  80  


Phe Leu Val Met Lys Gln Ser Gly Ile Asn Ile Pro Thr Glu Glu Gln 
                85                  90                  95      


Glu Thr Lys Leu His Lys Glu Glu Ile Gln Leu Ile Gln Glu His Leu 
            100                 105                 110         


Ile Ser Leu Tyr Glu Leu Leu Asp Asp Leu Arg Asn Glu Gln Thr His 
        115                 120                 125             


Tyr Met His Asp Pro Val Ile Ile Pro Glu Glu Val Ser Lys Met Leu 
    130                 135                 140                 


Asp Ala Leu Leu Leu Gln Ile Leu Lys Asn Thr Arg Lys Lys Cys Lys 
145                 150                 155                 160 


Asp Asp Glu Tyr Arg Thr Phe Ile Val Lys Lys Tyr Gln Glu Glu Phe 
                165                 170                 175     


Gln Lys Glu Ile Lys Val Gln Val Lys Asp Arg Phe Gly Lys Glu Lys 
            180                 185                 190         


Glu Lys Ile Val Thr Gly Glu Val Lys Glu Asn Tyr Val Ile Asn Arg 
        195                 200                 205             


Cys Phe Arg Lys Trp Ile Gln Lys Glu Gly Glu Glu Glu Thr Leu Arg 
    210                 215                 220                 


Tyr Ser Thr Val Gln Glu Glu Gln Gly Lys Tyr Val Trp Ser Ser Ser 
225                 230                 235                 240 


Gly Phe Val Phe Phe Leu Ser Leu Phe Leu Arg Arg Lys Glu Leu Glu 
                245                 250                 255     


Asp Val Met Asn His Val Pro Tyr Phe Lys Asp Ser Arg Lys Leu Leu 
            260                 265                 270         


Phe Tyr Leu Thr Arg Lys Thr Phe Ser Ser Tyr Cys Phe Arg Asp Leu 
        275                 280                 285             


Arg Lys Ser Leu Arg Ser Asp Tyr Ser Asn Asp Ser Leu Leu Met Gln 
    290                 295                 300                 


Met Ile Glu Glu Leu Tyr Lys Cys Pro Gly Glu Leu Tyr Glu Val Leu 
305                 310                 315                 320 


Leu Lys Glu Gln Lys Gln Glu Phe Ile Glu Asp Ile Asn Glu Tyr Tyr 
                325                 330                 335     


Lys Asp Asn Pro Glu Phe Glu Gly Ser Ala Asn Glu Ala Gln Val Ile 
            340                 345                 350         


His Pro Val Ile Arg Lys Arg Tyr Gln Asp Lys Phe Pro Tyr Phe Ala 
        355                 360                 365             


Leu Arg Phe Ile Asp Glu Tyr Phe Asn Phe Pro Thr Leu Arg Phe Gln 
    370                 375                 380                 


Leu Val Leu Gly Glu Tyr Val Thr Asp Arg Arg Thr Lys Glu Leu Gln 
385                 390                 395                 400 


Gly Thr Ala Leu Phe Thr Asp Arg Val Ile Ser Gln Arg Ile Ser Tyr 
                405                 410                 415     


Val Gly Lys Leu Ser Glu Ala Glu Met Asn Lys Lys Arg Glu Gly Tyr 
            420                 425                 430         


Thr Glu Thr Gly Trp Lys Glu Tyr Pro Asn Pro Tyr Tyr Lys Ile Glu 
        435                 440                 445             


Asn Asn Arg Ile Pro Leu Tyr Ile Glu Phe Ser Lys Asn Glu Glu Leu 
    450                 455                 460                 


Ile Phe Lys Glu Lys Lys Phe Lys Tyr Asn Thr Leu Ala Lys Trp Glu 
465                 470                 475                 480 


Asn Arg Glu Ile Asp Lys Arg Thr Gly Glu Phe Asn Gln Val Asn Lys 
                485                 490                 495     


Gln Arg Arg Ile Thr Gln Leu Glu Glu Phe Lys Ile Asp Asn Pro Lys 
            500                 505                 510         


Lys Met Lys Thr Pro Asn Val Phe Leu Ser Ile Tyr Glu Leu Pro Ala 
        515                 520                 525             


Leu Leu His Ala Leu Leu Ile Glu Lys Lys Thr Glu Ala Glu Ile Glu 
    530                 535                 540                 


Asp Ile Ile Lys Ala Lys Ile Lys Lys Gln Leu Thr Glu Ile Ala Glu 
545                 550                 555                 560 


Gly Arg Arg Asn Leu Ser Gly Leu Pro Lys Gly Ile Lys Lys Met Arg 
                565                 570                 575     


Asn Cys Asn Ser Asp Phe Glu Lys Lys Lys Leu Ile Ser Asp Ile Asp 
            580                 585                 590         


Asn Glu Ile Lys Lys Gly Glu Lys Ile Leu Glu Glu Val Gln Gln Trp 
        595                 600                 605             


Leu Asn Pro Val Ile Asn Lys Lys Gly Thr Gly Lys Gln Glu Asn Asn 
    610                 615                 620                 


Lys Pro Phe Phe Ser Asn Thr Tyr Arg Gly Lys Tyr Ala Thr Trp Leu 
625                 630                 635                 640 


Ala Tyr Asp Ile Lys Arg Phe Thr Gly Lys Asp His Ile Gln Asn Trp 
                645                 650                 655     


Lys Gly Tyr Gln Phe Ser Glu Leu Gln Thr Leu Leu Ser Leu Tyr Thr 
            660                 665                 670         


Leu Arg Lys Glu Glu Leu Lys Asn Phe Leu Glu Lys Asp Leu Gln Leu 
        675                 680                 685             


Thr Ser His Pro Phe Leu Lys Glu Ala Leu Lys Ala Val Asn Leu Glu 
    690                 695                 700                 


Asp Phe Met Gly Ala Tyr Leu Arg Gly Arg Gln Phe Phe Leu Glu Lys 
705                 710                 715                 720 


Ala Lys Lys Gln Ile Gly Ile Lys Gly Val Lys Lys Ser Ile Phe Gln 
                725                 730                 735     


Tyr Phe Glu Glu Arg Lys Tyr Lys Ile Tyr Ser Ser Asn Leu Asp Tyr 
            740                 745                 750         


Trp Glu Glu Leu Trp Lys His Pro Val Asn Leu Asp Arg Gly Leu Phe 
        755                 760                 765             


Asp Glu Arg Gly Thr Val Tyr Asn Lys Asn Lys Glu Leu Asn Asp Leu 
    770                 775                 780                 


Gln Asn Arg Ala Ala Trp Phe Ser Phe Ala Glu Thr Asn Pro Lys Gln 
785                 790                 795                 800 


Gln Phe Tyr His Phe Pro Arg Ile Tyr Ser Asp Glu Asp Ile Thr Lys 
                805                 810                 815     


Pro Val Thr Asp Arg Tyr Gly Lys Thr Lys Glu Lys Leu Ile Leu Phe 
            820                 825                 830         


Lys Leu Ser Pro Gln Lys Gly Phe Met Glu Gln Ile Pro Ser Asp Leu 
        835                 840                 845             


Lys Lys Lys Tyr Gln Glu Asp Lys Gly Lys Val Glu His Pro Glu Val 
    850                 855                 860                 


Gln Lys Glu Lys Lys Tyr Glu Glu Lys Lys His Pro Gly Ile Asn Ala 
865                 870                 875                 880 


Phe Ile Lys Asn Ala Tyr Lys Asn Glu Gln Lys Ile Arg Arg Ile Ser 
                885                 890                 895     


Arg Asn Asp Ile Phe Leu Tyr Glu Met Val Lys Tyr Met Leu Asn Lys 
            900                 905                 910         


Ile Ser Pro Ala Thr Glu Phe Ser Ser Leu Asp Lys Val Trp Leu Thr 
        915                 920                 925             


Arg Ile Glu Arg Glu Lys Gln Ala Thr Glu Ala Arg Glu Gln Ser Phe 
    930                 935                 940                 


Lys Glu Lys Gly Asp Thr Ser Glu Asn Lys Ile Arg Gln Asp Tyr Leu 
945                 950                 955                 960 


Leu Ser Phe Pro Ile Thr Leu Thr Leu Phe Asn Asp Ile Ile Lys Glu 
                965                 970                 975     


Lys Val Lys Ile Lys Asp Ile Gly Arg Phe Arg Lys Leu Glu Lys Asp 
            980                 985                 990         


Glu Arg Val Gln Thr Met Ile Ser  Tyr Tyr Thr Ser Gly  Leu Trp Lys 
        995                 1000                 1005             


Asn Asp  Gln Pro Ser Leu Thr  Ile Lys Glu Leu Glu  Ala Glu Leu 
    1010                 1015                 1020             


Glu Ser  Tyr His Lys Ile Arg  Leu Gln Glu Ile Phe  Lys Glu Val 
    1025                 1030                 1035             


His Lys  Leu Glu Lys Glu Ile  Tyr Glu Phe Thr Pro  Glu Glu Asp 
    1040                 1045                 1050             


Lys Ser  Lys Leu Leu Ala Arg  Glu Ser Phe Pro Lys  Phe Lys Tyr 
    1055                 1060                 1065             


Tyr Ile  Ser Phe Tyr Phe Ile  Pro Lys Glu Asp Gln  Glu Val Phe 
    1070                 1075                 1080             


Asn Glu  Ile Gln Phe Asp Lys  Tyr Lys Asn Leu Glu  Gln Ile Pro 
    1085                 1090                 1095             


Gly Arg  Lys Pro Glu Tyr Asp  Pro Tyr Tyr Leu Leu  Ile Phe Ile 
    1100                 1105                 1110             


Arg Asn  Lys Phe Ala His Asn  Gln Leu Pro Ala Glu  Pro Ile Tyr 
    1115                 1120                 1125             


Lys Thr  Ala Leu Thr Phe Leu  Pro Asn Asn Phe Asn  Thr Leu Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr His Lys Leu Phe  Ile Leu Leu Asn Asn  Lys Asn Tyr 
    1145                 1150                 1155             


Asn Asn  
    1160 


<210> 64
<211> 1160
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13b sequence"

<400> 64
Met Asn Ile Leu Pro Ala Ala Pro Glu Lys Glu Lys Ile Ala Tyr Ser 
1               5                   10                  15      


Thr Ala Thr Ala Pro Trp Phe Phe Gly Ala Phe Leu Asn Gln Ala Arg 
            20                  25                  30          


His Asn Leu Phe Leu Thr Val Asn Asp Leu Ala Ile Arg Leu Gly Glu 
        35                  40                  45              


Lys Val Ile Asp Tyr Asp Asp Gln Leu Leu Asn Ser Asn Val Val Arg 
    50                  55                  60                  


Met Leu Val Asn Glu Lys Ala Ser Pro Leu Gln Leu Glu Ile Leu Met 
65                  70                  75                  80  


Lys Tyr Leu Asp Arg His Leu Pro Phe Leu Ile Pro Met Gln Val Ala 
                85                  90                  95      


Leu Lys Gly His Gln Gly Asp Ala Ser Asp Asn Pro Val Ile Gly Ser 
            100                 105                 110         


Pro Ala Asp Tyr Gly Ala Ile Leu Ser Lys Leu Ile Val Cys Leu Asn 
        115                 120                 125             


Ala Ala Arg Asn His Phe Ser His Tyr His Ser Thr Ser Gly Trp Ser 
    130                 135                 140                 


Gly Tyr Asn Glu Val Ile Glu Trp Met Glu His Val Phe Thr Arg Asn 
145                 150                 155                 160 


Ile Glu Thr Val Val Lys Arg Phe Thr Leu Thr Glu Glu Glu Val Gln 
                165                 170                 175     


His Leu Lys Lys Pro Val Asp Lys Ser Pro Lys Gly Thr Ile Pro Pro 
            180                 185                 190         


Tyr Tyr Phe Ser Phe Cys Lys Gly Asp Ile Trp Thr Asp Thr Gly Leu 
        195                 200                 205             


Ala Phe Phe Ile Cys Leu Phe Leu Thr Arg Glu Glu Ala Tyr Leu Phe 
    210                 215                 220                 


Leu Lys Lys Leu Arg Gly Phe Lys Arg Gly Glu Glu Arg Phe His Lys 
225                 230                 235                 240 


Ala Thr Leu Glu Ala Phe Cys Val Gly Ser Leu Lys Val Pro Arg Glu 
                245                 250                 255     


Arg Leu Glu Ser Asn Asn Ser Pro Gln Ser Ala Phe Leu Asp Met Cys 
            260                 265                 270         


Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Phe Asp Leu Leu Glu Pro 
        275                 280                 285             


Glu Lys Gln Glu Leu Phe Arg Arg Asp Pro Glu Pro Glu Asp Ala Glu 
    290                 295                 300                 


Asp Asn Gly Ile Glu Glu Glu Glu Asp Gln Pro Gln Ala Leu Leu Val 
305                 310                 315                 320 


Arg Lys Glu Asn Arg Phe Ser Tyr Phe Ala Leu Arg Tyr Leu Asp Ile 
                325                 330                 335     


Ala Lys Ala Phe Pro Arg Leu Arg Phe Gly Val Asp Leu Gly Thr Tyr 
            340                 345                 350         


Phe Phe Ser Val Tyr Pro Lys Thr Phe Ala Gly Ile Glu Glu Thr Arg 
        355                 360                 365             


Gln Leu Ser Lys Arg Leu Ile Gly Tyr Gly Lys Leu Glu Glu Phe Ala 
    370                 375                 380                 


Arg Glu Lys Arg Pro Glu His Ile Ala Ala Leu Phe Arg Ser Lys Glu 
385                 390                 395                 400 


Glu Ala Asn Ala Ala Pro Thr Glu Pro Phe Ile Arg Glu Thr Ala Pro 
                405                 410                 415     


His Tyr His Leu Asp Gly Asn Asn Val Tyr Leu Tyr Met Ser Gly Asp 
            420                 425                 430         


Gly Glu Ala Gln Trp Pro Ala Val Glu Leu Glu Glu Val Thr Gly Lys 
        435                 440                 445             


Ser Tyr Pro Arg Lys Leu Val Lys Lys Ser Thr Leu Leu Pro Phe Ala 
    450                 455                 460                 


Val Leu Thr Val Asn Glu Leu Pro Ala Leu Leu Phe Tyr His Leu Leu 
465                 470                 475                 480 


His Lys Glu Lys Gly Ala Gly Asp Ala Ala Glu Arg Val Ile Ile Asn 
                485                 490                 495     


His Met Glu Arg Val Lys Arg Phe Phe Lys Ala Leu Gln Asp Asp Lys 
            500                 505                 510         


Val Asp Gln Val Ala Gly Gln Pro Ile Arg Lys Pro Asp Val Asp Ala 
        515                 520                 525             


Asp Glu Ser Leu His Met Glu Tyr Asp Arg Arg Trp Lys Leu Leu Lys 
    530                 535                 540                 


Lys Lys Leu Ser Glu Tyr Gln Leu Arg Ala Ser Tyr Ile Pro Glu Lys 
545                 550                 555                 560 


Ile Ile Asn Tyr Leu Leu Asn Ile Glu Ala Val Asp Leu Gly Asp Lys 
                565                 570                 575     


Ala Met Ala Gln Leu Lys Asn Leu Gln Arg Gln Ala Gln Asp Asp Ile 
            580                 585                 590         


Ala Ala Ile Glu Arg Arg Met Glu His Leu Met Lys Lys Gly Ala Asp 
        595                 600                 605             


Gly Arg Lys Thr Leu Lys Val Gly Asn Leu Ala Gln Gln Leu Ala Glu 
    610                 615                 620                 


Asp Met Leu Gln Met Gln Pro Val Gln Ile Gly Thr Asp Gly Glu Pro 
625                 630                 635                 640 


Val Pro Ala Ser Lys Ala Asn Asn Leu Ala Phe Arg Leu Leu Gln Ser 
                645                 650                 655     


His Leu Ala Tyr Phe Ala Glu Asn Arg His Asn Leu Pro Ala Val Phe 
            660                 665                 670         


Glu Ala Cys Gly Leu Ile Gly Ala Ser Asn Lys His Pro Phe Leu Asp 
        675                 680                 685             


Asn Ile Asn Ile Glu Ser Cys Lys Gly Val Val Asp Phe Phe Ile Leu 
    690                 695                 700                 


Asn Phe Arg Asn Lys Leu Asp Phe Leu Asp Arg Cys Leu Gln Glu Gly 
705                 710                 715                 720 


Glu Trp His Arg Tyr His Phe Ile Ser Ala Ala Lys Leu Lys Ser Gly 
                725                 730                 735     


Ala Lys Val Thr Ile Lys Lys Tyr Leu Asn Glu Ala Phe Glu Ser Lys 
            740                 745                 750         


Gly Arg Asn His Ile Pro Phe Thr Leu Pro Pro Ser Leu Phe Leu Asp 
        755                 760                 765             


Ala Ser Leu Asp Trp Leu Ala Lys Phe Gly Asp Gly Lys Ala Lys Lys 
    770                 775                 780                 


Val Leu Ala Glu Asn Glu Tyr Val Asn Ser Val Phe Leu Ile Arg Arg 
785                 790                 795                 800 


Leu Phe Ala Asp Gly Gly Leu Gln Pro Phe Tyr Ala Trp Lys Arg Glu 
                805                 810                 815     


Tyr Arg Leu Phe Glu Lys Lys Ala Gly Lys Ala Val Phe Leu Asp Glu 
            820                 825                 830         


Ala Gly Arg Met Arg Lys Ala Asp Lys Ile Gly Ile Glu Val Glu Arg 
        835                 840                 845             


His Arg Glu Phe Leu Ala Arg Pro Val Lys Lys Gly Lys Gln Tyr Asp 
    850                 855                 860                 


Ile Lys Lys Ala Ala Ala Glu Gln Phe Leu Arg Ser Tyr Arg Phe Tyr 
865                 870                 875                 880 


Leu Gln Glu Glu Lys Tyr Ile Arg Leu Leu Ala Ala Gln Asp Met Leu 
                885                 890                 895     


Leu Phe Arg Cys Ile Cys Asp Leu Leu Thr Tyr His Val Gly Asp Ile 
            900                 905                 910         


Gly Leu Glu Glu Leu Ala Glu Ala Lys Ala Gly Thr Phe Ser Leu Ala 
        915                 920                 925             


Asn Ile Thr Pro Glu Lys Thr Glu Thr Ala Lys Ser Leu Leu Asn Tyr 
    930                 935                 940                 


Arg Pro Ala Gly Gly Val Val Leu Asp Arg His Phe Tyr Ala Thr Asp 
945                 950                 955                 960 


Glu Lys Gly Ala Phe Val Lys Gln Glu Gly Lys Leu Val Pro Gly Gly 
                965                 970                 975     


Gln Val Arg Ile Phe Asp Asn Thr Leu Lys Ile Lys Asn Ala Gly Asn 
            980                 985                 990         


Phe Arg Lys Leu Leu Lys Asp Arg  Arg Met Asn Asn Leu  Phe Phe Tyr 
        995                 1000                 1005             


Phe Lys  Gln His Ala Asp Glu  Pro Val Val Leu His  Arg Met Val 
    1010                 1015                 1020             


Leu Glu  Asn Glu Leu Arg Ala  Tyr Asp Arg Met Arg  Leu Lys Val 
    1025                 1030                 1035             


Leu Pro  Val Ile Ala Glu Phe  Glu Lys Lys Leu Tyr  Gln His Cys 
    1040                 1045                 1050             


Thr Asp  Val Glu Lys Glu Arg  Leu Val Val Asn Gly  Ser Met His 
    1055                 1060                 1065             


His Arg  Cys Tyr Leu Asp Val  Tyr Arg Glu Lys Tyr  Gln Pro Asp 
    1070                 1075                 1080             


Trp Gly  Trp Glu Ala Ala Gly  Asn Leu Leu Arg Ile  Arg Asn Ala 
    1085                 1090                 1095             


Phe Val  His Asn Gln Phe Pro  Leu Met Glu Gly Asp  Gly Phe Lys 
    1100                 1105                 1110             


Leu Glu  Val Ala His Trp Lys  Lys Ile Asn Ala Asp  Phe Val Pro 
    1115                 1120                 1125             


Ser Glu  Gln Gly Ser Ser Leu  Gly Tyr Gly Ile Ile  Asp Arg Leu 
    1130                 1135                 1140             


Gly Gln  Leu Ala Val Glu Gly  Tyr Glu Gly Leu Ile  Lys Asn Ile 
    1145                 1150                 1155             


His Val  
    1160 


<210> 65
<211> 817
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13b sequence"

<400> 65
Met Gly Glu Glu Glu Gln Ala His Ile Leu Glu Asn Ser Leu Asn Asp 
1               5                   10                  15      


Glu Leu Cys Glu Ala Ile Asp Asp Pro Phe Glu Met Ile Ala Ser Leu 
            20                  25                  30          


Ser Lys Arg Ala Arg Tyr Lys Asp Arg Phe Pro Tyr Leu Met Leu Arg 
        35                  40                  45              


Tyr Ile Glu Glu Lys Asn Leu Leu Pro Phe Ile Arg Phe Arg Ile Asp 
    50                  55                  60                  


Leu Gly Cys Leu Glu Leu Ala Ser Tyr Pro Lys Lys Met Gly Glu Glu 
65                  70                  75                  80  


Asn Asn Tyr Glu Arg Ser Val Thr Asp His Ala Met Ala Phe Gly Arg 
                85                  90                  95      


Leu Thr Asp Phe His Asn Glu Asp Glu Val Leu Gln Gln Ile Thr Lys 
            100                 105                 110         


Gly Ile Thr Asp Glu Val Arg Phe Ser Leu Tyr Ala Pro Arg Tyr Ala 
        115                 120                 125             


Ile Tyr Asn Asn Lys Ile Gly Phe Val Trp Thr Ser Arg Ser Lys Lys 
    130                 135                 140                 


Lys Ser Phe Pro Thr Leu Lys Lys Lys Glu Gly Glu Gly His Arg Val 
145                 150                 155                 160 


Ala Tyr Thr Leu Gln Asn Glu Glu Ser Phe Gly Phe Ile Ser Ile Tyr 
                165                 170                 175     


Asp Leu Arg Lys Ile Leu Leu Leu Ser Phe Leu Asp Glu Gly Lys Asn 
            180                 185                 190         


Ile Val Ser Gly Leu Phe Lys Gln Ser Lys Ala Asn Trp Glu Asn Leu 
        195                 200                 205             


Ser Glu Asn Leu Phe Asp Ala Ile Arg Thr Glu Leu Gln Lys Glu Phe 
    210                 215                 220                 


Pro Val Pro Leu Ile Arg Tyr Thr Leu Pro Arg Ser Lys Gly Gly Lys 
225                 230                 235                 240 


Phe Val Asp Pro Lys Leu Ala Asp Lys Gln Glu Lys Tyr Glu Ser Glu 
                245                 250                 255     


Phe Glu Arg Arg Lys Glu Lys Leu Ser Glu Ile Leu Ser Glu Lys Gly 
            260                 265                 270         


Phe Asp Leu Ser Gln Ile Pro Arg Arg Met Ile Asp Glu Trp Leu Asn 
        275                 280                 285             


Val Leu Pro Thr Ser Lys Glu Lys Lys Leu Lys Gly Tyr Val Glu Thr 
    290                 295                 300                 


Leu Lys Leu Asp Cys Arg Glu Arg Leu Arg Val Phe Glu Lys Arg Glu 
305                 310                 315                 320 


Lys Gly Glu His Pro Val Pro Pro Arg Ile Gly Glu Met Ala Thr Asp 
                325                 330                 335     


Leu Ala Lys Asp Ile Ile Arg Met Val Ile Asp Gln Gly Met Lys Gln 
            340                 345                 350         


Arg Ile Thr Ser Ala Tyr Tyr Ser Glu Ile Gln Arg Cys Leu Ala Gln 
        355                 360                 365             


Tyr Ala Gly Asp Asp Asn Arg Arg His Leu Asp Ser Ile Ile Arg Glu 
    370                 375                 380                 


Leu Gly Leu Lys Asp Arg Lys Lys Gly His Pro Phe Leu Gly Lys Val 
385                 390                 395                 400 


Leu Arg Pro Asp Leu Asp His Thr Glu Lys Leu Tyr Gln Arg Tyr Phe 
                405                 410                 415     


Lys Glu Lys Lys Glu Trp Leu Glu Ala Thr Phe Tyr Pro Ala Ala Asn 
            420                 425                 430         


Pro Lys Arg Val Pro Arg Phe Val Asn Pro Pro Ala Glu Lys Gln Lys 
        435                 440                 445             


Glu Leu Pro Leu Ile Ile His Asn Leu Met Lys Glu Arg Pro Glu Trp 
    450                 455                 460                 


Arg Asp Trp Lys Gln Arg Lys Asn Ser His Pro Ile Asp Leu Pro Ser 
465                 470                 475                 480 


Gln Leu Phe Glu Asn Glu Ile Cys Arg Leu Leu Lys Asp Lys Ile Gly 
                485                 490                 495     


Lys Glu Ser Ser Gly Lys Leu Lys Trp Asn Glu Met Phe Lys Leu Tyr 
            500                 505                 510         


Trp Asp Lys Glu Phe Pro Asn Gly Met Gln Arg Phe Tyr Arg Cys Lys 
        515                 520                 525             


Arg Arg Val Glu Val Phe Asp Lys Val Val Glu Tyr Glu Tyr Ser Glu 
    530                 535                 540                 


Glu Gly Gly Asn Tyr Lys Lys Tyr Tyr Glu Ala Leu Ile Asn Glu Val 
545                 550                 555                 560 


Val Arg Gln Lys Ile Ser Ser Ser Lys Glu Asn Ser Lys Leu Gln Val 
                565                 570                 575     


Glu Asp Leu Thr Leu Ser Val Arg Arg Ala Phe Lys Arg Ala Ile Asn 
            580                 585                 590         


Glu Lys Glu Tyr Gln Leu Arg Leu Val Cys Glu Asp Asp Arg Leu Leu 
        595                 600                 605             


Phe Met Ala Val Arg Asp Leu Tyr Asp Trp Lys Glu Val Gln Leu Asp 
    610                 615                 620                 


Leu Asn Lys Ile Asp Asn Met Leu Gly Glu Pro Val Ser Val Ser Gln 
625                 630                 635                 640 


Val Ile Gln Leu Glu Asn Gly Gln Pro Asp Ala Val Ile Lys Ala Glu 
                645                 650                 655     


Cys Lys Leu Lys Asp Val Ser Lys Leu Met Arg Tyr Cys Tyr Asp Gly 
            660                 665                 670         


Arg Val Lys Gly Leu Met Pro Tyr Phe Ala Asn His Glu Ala Thr Gln 
        675                 680                 685             


Glu Gln Val Glu Val Glu Leu Arg His Tyr Glu Asp His Arg Arg Arg 
    690                 695                 700                 


Val Phe Asp Trp Val Phe Ala Leu Glu Lys Ser Val Leu Lys Asn Glu 
705                 710                 715                 720 


Lys Leu Arg Arg Leu Tyr Glu Lys Ser Gln Glu Gly Cys Glu His Arg 
                725                 730                 735     


Arg Cys Ile Asp Ala Leu Arg Lys Ala Thr Leu Val Ser Glu Glu Glu 
            740                 745                 750         


Tyr Lys Phe Leu Val His Ile Arg Asn Lys Ser Ala His Asn Gln Phe 
        755                 760                 765             


Pro Asp Leu Glu Phe Gly Lys Leu Thr Pro Asn Val Thr Ser Gly Phe 
    770                 775                 780                 


Cys Glu Cys Ile Trp Ser Lys Tyr Lys Ala Ile Ile Cys Arg Ile Ile 
785                 790                 795                 800 


Pro Phe Ile Asp Pro Glu Arg Arg Phe Phe Gly Lys Leu Leu Glu Gln 
                805                 810                 815     


Lys 
    


<210> 66
<211> 1114
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13b sequence"

<400> 66
Met Arg Ile Pro Lys Leu Ile Glu Glu His Lys Ser Val Phe Gly Ala 
1               5                   10                  15      


Tyr Ser Thr Met Ala Leu Ser Asn Val Glu Thr Val Leu Asn His Ile 
            20                  25                  30          


Ala Glu Arg Ala Gly Leu Asp Gly Tyr Glu Arg Asp Arg Gly Pro Gly 
        35                  40                  45              


Val Glu Asp Tyr Trp Glu His Pro Val Met Gln Cys Leu Cys Arg Lys 
    50                  55                  60                  


Asp Lys Pro Arg Ser Ile Pro Ser Asp Val Leu Leu Asp Val Arg Asn 
65                  70                  75                  80  


Arg Leu Phe Arg Ser Phe Pro Phe Leu Lys Ile Met Ala Glu Asn Gln 
                85                  90                  95      


Arg Asp Tyr Arg Asn Ala Lys Gly Lys Val Glu Cys Val Glu Ile Asn 
            100                 105                 110         


Glu Ser Asp Ile Phe Val Val Leu Asn Asn Ser Phe Arg Val Leu Lys 
        115                 120                 125             


Ala Tyr Arg Asp Thr Cys Thr His Tyr Leu Ile Glu Asn Arg Ile Trp 
    130                 135                 140                 


Glu Asp Asn Ser Pro Met Leu Met Tyr Asn Glu Cys Pro Leu Ala Ala 
145                 150                 155                 160 


Met Val Asn Gln Tyr Tyr Thr Ala Ala Leu Arg Val Thr Lys Glu Arg 
                165                 170                 175     


Tyr Gly Tyr Glu Thr Arg Asp Leu Thr Phe Ile Gln Lys Arg Arg Phe 
            180                 185                 190         


Lys Gln Glu Pro Glu Lys Glu Ala Ser Gly Asn Val Lys Lys Lys Ala 
        195                 200                 205             


Val Pro Asp Leu Ala Phe Phe Leu Ser Leu Val Ala Leu Asn Gly Asp 
    210                 215                 220                 


Gly Arg Lys Trp Leu His Leu Ser Gly Trp Gly Val Val Leu Leu Ile 
225                 230                 235                 240 


Cys Leu Phe Leu Glu Lys Lys Tyr Val Asn Val Phe Leu Ser Lys Leu 
                245                 250                 255     


Pro Asn Pro Gly Asn Tyr Pro Pro Ser Ser Lys Glu Arg Arg Ile Ile 
            260                 265                 270         


Arg Arg Ser Met Gly Val Cys Ser Val Val Leu Pro Lys Glu Arg Ile 
        275                 280                 285             


His Ser Glu Thr Gly Asp Leu Ser Val Ala Leu Asp Met Leu Asn Glu 
    290                 295                 300                 


Leu Lys Arg Cys Pro Arg Glu Leu Phe Asp Thr Leu Ser Pro Gly Asp 
305                 310                 315                 320 


Gln Glu Arg Phe Arg Thr Ile Ser Ser Asp His Asn Glu Val Leu Gln 
                325                 330                 335     


Met Arg Ser Lys Asp Arg Phe Ala Gln Leu Val Leu Gln Tyr Ile Asp 
            340                 345                 350         


His Asn Arg Leu Phe Glu Asn Leu Arg Phe His Val Asn Met Gly Lys 
        355                 360                 365             


Leu Arg Tyr Leu Phe Asn Pro Lys Lys Tyr Cys Ile Asp Gly Gln Thr 
    370                 375                 380                 


Arg Val Arg Val Leu Glu His Pro Leu Asn Gly Phe Gly Arg Leu Gln 
385                 390                 395                 400 


Glu Met Glu Glu Lys Arg Leu Gln Glu Asn Gly Pro Phe Ala Arg Ser 
                405                 410                 415     


Gly Ile Lys Val Arg Cys Phe Asp Glu Val Arg Arg Asp Asp Ala Asn 
            420                 425                 430         


Glu Ser Asn Tyr Pro Tyr Ile Val Asp Thr Tyr Thr His Tyr Val Leu 
        435                 440                 445             


Glu Asn Asp Met Val Glu Met Phe Phe Cys Pro Glu Gly Ser Gly Met 
    450                 455                 460                 


Lys Met Pro Glu Val Thr Ser Arg Glu Gly Lys Trp Tyr Val Asp Lys 
465                 470                 475                 480 


Lys Val Pro His Cys Arg Met Arg Met Ser Val Leu Glu Leu Pro Ala 
                485                 490                 495     


Met Leu Phe His Leu Leu Leu Cys Gly Ala Lys Asn Thr Glu Val His 
            500                 505                 510         


Ile Gly Lys Val Cys Asp Asn Tyr Cys His Leu Phe Ser Asp Met Ala 
        515                 520                 525             


Gln Gly Asn Leu Thr Glu Glu Asn Ile Leu Ser Tyr Gly Ile Lys Lys 
    530                 535                 540                 


Glu Asp Ile Pro Gln Lys Val Trp Asp Cys Val Arg Gly Val His Met 
545                 550                 555                 560 


Gly Lys Asp Ser Arg Ala Tyr Arg Glu Lys Glu Ile Arg Glu Arg Tyr 
                565                 570                 575     


Glu Asp Val Thr Arg Arg Leu Glu Arg Leu Glu Ala Asp Arg Lys Ala 
            580                 585                 590         


Val Leu Gly Gly Glu Asn Lys Ile Gly Lys Arg Gly Phe Val Gln Ile 
        595                 600                 605             


Val Pro Gly Arg Leu Ala Ala Tyr Leu Ala Thr Asp Ile Cys Arg Leu 
    610                 615                 620                 


Gln Pro Ser Leu Arg Lys Gly Asp Gly Tyr Gly Thr Asp Arg Leu Thr 
625                 630                 635                 640 


Gly Leu Asn Phe Arg Leu Leu Gln Ser Ser Ile Ala Thr Tyr Asn Cys 
                645                 650                 655     


Gly Glu Ser Asp Ile Leu Tyr Gly Arg Phe Arg Asp Val Phe Cys Ser 
            660                 665                 670         


Ala Gly Leu Ile Gly Gly Asp Asn Pro His Pro Phe Leu Asp Lys Val 
        675                 680                 685             


Leu Pro Glu Ala Tyr Ser Val Cys Cys Pro Arg Asn Thr Ile Glu Phe 
    690                 695                 700                 


Tyr Glu Arg Tyr Leu Glu Glu Tyr Gln Arg Tyr Leu Lys Pro Leu Val 
705                 710                 715                 720 


Ile Lys Leu Glu Lys Gly Lys Val Pro Ser Leu Ser Phe Val Asn Glu 
                725                 730                 735     


Gly Gln Arg Arg Trp Ala Arg Arg Asp Asp Ala Tyr Tyr His Glu Leu 
            740                 745                 750         


Gly Asn Leu Tyr Leu Ser Gln Ala Ile Glu Leu Pro Arg Gln Met Phe 
        755                 760                 765             


Asp Asp Glu Ile Lys Asp Lys Leu Arg Glu Met Pro Glu Met Arg Asp 
    770                 775                 780                 


Val Asp Phe Asp His Ala Asn Val Thr Phe Leu Ile Gly Glu Tyr Leu 
785                 790                 795                 800 


Lys Arg Val Arg His Asp Glu Ser Gln Glu Phe Tyr Ser Trp Pro Arg 
                805                 810                 815     


His Tyr Lys Tyr Val Asp Met Leu Lys Cys Ile Leu Asn Pro Lys Asn 
            820                 825                 830         


Gly Ser Leu Gln Ala Val Tyr Ile Gln Met Gly Glu Arg Glu Gly Leu 
        835                 840                 845             


Trp Gln Glu Arg Ser Glu Leu Glu Glu Lys Tyr Ala Lys Ile Arg Leu 
    850                 855                 860                 


Arg Asp Leu Gly Arg Lys Gly Leu Asp Lys Asp Glu Ala Asn Glu Arg 
865                 870                 875                 880 


Ile Lys Thr Gly Leu Gly Asn Arg Lys Lys Glu Tyr Gln Lys Ala Glu 
                885                 890                 895     


Lys Val Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Leu Phe Met Leu 
            900                 905                 910         


Ala Lys Asn Thr Leu Phe Asn Ser Val Glu Val Asp Asp Glu Arg Phe 
        915                 920                 925             


Lys Leu Lys Asp Ile Met Pro Asp Gly Glu Lys Gly Ile Leu Ser Glu 
    930                 935                 940                 


Val Val Pro Met Asp Phe Cys Phe Arg Ser Gly Asn Ser Ala Thr Arg 
945                 950                 955                 960 


Lys Leu Met Gly Thr Ile His Ser Asp Asn Thr Lys Ile Lys Asn Tyr 
                965                 970                 975     


Gly Asp Phe Phe Ala Leu Ala Asn Asp Lys Arg Met Val Thr Leu Leu 
            980                 985                 990         


Pro Leu Val Gly Glu Gln Cys Leu  Val Lys Glu Glu Val  Lys Glu Glu 
        995                 1000                 1005             


Phe Asp  Lys Tyr Asp Asp Cys  Arg Pro Glu Met Ile  Ser Met Val 
    1010                 1015                 1020             


Phe Asp  Phe Glu Gln Trp Ala  Tyr Ser Ala Tyr Pro  Glu Leu Lys 
    1025                 1030                 1035             


Glu Leu  Val Ser Asn Glu Ala  Ile Lys Gly Arg Leu  Phe Ser Asn 
    1040                 1045                 1050             


Leu Leu  Gln Glu Leu Leu Gly  Arg Gly Glu Leu Thr  Tyr Glu Glu 
    1055                 1060                 1065             


Lys Tyr  Ala Leu Val Gly Ile  Arg Asn Ala Phe Leu  His Asn Ser 
    1070                 1075                 1080             


Tyr Pro  Lys Asp Gly Gly Val  Val Lys Val Arg Thr  Leu Pro Asp 
    1085                 1090                 1095             


Ile Ala  Lys Ser Leu Lys Asp  Val Phe Lys Glu Tyr  Ile Arg Leu 
    1100                 1105                 1110             


Glu 
    


<210> 67
<211> 909
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas13b sequence"

<400> 67
Met Lys Met Phe Tyr Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val 
1               5                   10                  15      


Asp Ser Leu Arg Asn Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn 
            20                  25                  30          


Ile Arg Glu Ile Lys Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys 
        35                  40                  45              


Ile Gly Leu Leu Asn Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn 
    50                  55                  60                  


Leu Leu Lys Leu Arg Phe Met Ala Gly Glu Asp Glu Val Ala His Leu 
65                  70                  75                  80  


Arg Arg Cys Lys Ala Val Asn Lys Lys Val Val Val Arg Thr Glu Lys 
                85                  90                  95      


Asp Gly Phe Tyr Tyr Arg Leu Ser Asp Asn Gly Gly Val Thr Glu Lys 
            100                 105                 110         


Gly Val Ile Phe Ile Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe 
        115                 120                 125             


Leu Phe Leu Lys Gln Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg 
    130                 135                 140                 


Tyr Arg Leu Thr Leu Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro 
145                 150                 155                 160 


Val Asp Arg Leu Lys Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu 
                165                 170                 175     


Asp Met Leu Asn Glu Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr 
            180                 185                 190         


Leu Ser Val Asp Cys Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp 
        195                 200                 205             


Asp Leu Arg Ser Arg Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala 
    210                 215                 220                 


Leu Glu Phe Ile Ser Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr 
225                 230                 235                 240 


Thr Tyr Val Gly Asn Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile 
                245                 250                 255     


Asp Gly Thr Asp Lys Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe 
            260                 265                 270         


Tyr Lys Ser Val Asn Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr 
        275                 280                 285             


Gly Val Glu Ile Lys Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp 
    290                 295                 300                 


Ser Phe Arg Pro His Val Leu Arg Ala Thr Pro His Phe Val Ile Asn 
305                 310                 315                 320 


Thr Asn Asn Ile Gly Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Ile 
                325                 330                 335     


Val Asn Gly Lys Gly Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser 
            340                 345                 350         


Ile Tyr Glu Leu Pro Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys 
        355                 360                 365             


Asn Gly Lys Arg Phe Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu 
    370                 375                 380                 


Gly Val Glu Lys Lys Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala 
385                 390                 395                 400 


Leu Met Ala Arg His Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys 
                405                 410                 415     


Leu Asp Glu Val Lys Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly 
            420                 425                 430         


Lys Lys Gly Arg Val Val Leu Lys Ala Gly Arg Met Ala Asp Leu Leu 
        435                 440                 445             


Ala His Asp Met Val Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys 
    450                 455                 460                 


Ile Thr Gly Ala Asn Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe 
465                 470                 475                 480 


Lys Arg Asp Ile Leu Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr 
                485                 490                 495     


Gly Asn His Arg His Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys 
            500                 505                 510         


Ser Ser Leu Arg Asp Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys 
        515                 520                 525             


Tyr Phe Glu Asp Val Ala Lys Lys Ile Ala Lys Asn Lys Leu Asn Thr 
    530                 535                 540                 


Pro Cys His Ile Leu Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu 
545                 550                 555                 560 


Ala Gly Lys Asp Val Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr 
                565                 570                 575     


Asp Ser Ile Lys Asn Cys Leu Glu Gln Ser Lys Leu Asn Ile Tyr Ile 
            580                 585                 590         


Arg Asn Ala Arg Asn Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu 
        595                 600                 605             


Ile Leu Met Tyr Tyr Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe 
    610                 615                 620                 


Tyr Gly Glu Lys Arg Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu 
625                 630                 635                 640 


Asp Leu Ala Glu Arg Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys 
                645                 650                 655     


Ile Asp Val Ser Glu Ala Asn Met Pro Met Ser Lys Glu Glu His Leu 
            660                 665                 670         


Met Arg Lys Arg Tyr His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg 
        675                 680                 685             


Met Tyr Gln Val Gln Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile 
    690                 695                 700                 


Phe Lys Lys Ala Leu Ser Glu Gly Val Met Ser Lys Lys Ile Gly Leu 
705                 710                 715                 720 


Glu Asn Leu Asn Gly Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn 
                725                 730                 735     


Phe Asp Asn Ile Lys Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr 
            740                 745                 750         


Gly Lys Val Cys Arg Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile 
        755                 760                 765             


Lys Ala Phe His Lys Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser 
    770                 775                 780                 


Asp Tyr Leu Lys Glu Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met 
785                 790                 795                 800 


Val Lys Leu Cys Arg Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His 
                805                 810                 815     


Leu Ser Leu Asp Gly Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile 
            820                 825                 830         


Lys Pro Tyr Asn Asp Lys Tyr Asn Val Phe Asn Gly Gly Asp Leu Thr 
        835                 840                 845             


Phe Phe Ile Asn Ala Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr 
    850                 855                 860                 


Glu Cys Val Lys Tyr Val Val Ser Glu His Phe Lys Gly Ser Leu Asn 
865                 870                 875                 880 


Asp Val Ser Phe Ala Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu 
                885                 890                 895     


Glu Ser Met Arg Lys Lys Thr Gly Leu Arg Ile Asp Ile 
            900                 905                 


<210> 68
<211> 821
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12g sequence"

<400> 68
Met Leu Pro Thr Arg Tyr Lys Pro Ala Arg Thr Leu Val Arg Pro Leu 
1               5                   10                  15      


Gly Arg Leu Pro His Glu Pro Arg Lys Glu Phe Val Glu Lys Cys Arg 
            20                  25                  30          


Arg Val Arg Met His Phe Glu Gln Phe Asn Ile Asp Val Ala Asp Leu 
        35                  40                  45              


Cys Gln Trp Leu Met Ser Leu Arg Pro Asn Thr Arg Ile Gly Asp Ala 
    50                  55                  60                  


Gln Ser Thr Val Phe Trp Asp Phe Phe Leu Asn Pro Ser Ile Leu Thr 
65                  70                  75                  80  


Val Glu Ala Asp Glu Lys Glu Arg Asp Arg Trp Arg Leu Ala Ala Phe 
                85                  90                  95      


Asp Glu Leu Leu Gln Ile Arg Phe Gly His Asp Pro Asn Ala Pro Pro 
            100                 105                 110         


Trp Ser Glu Glu Phe Arg Ser Ala Ile Arg His Val Ala Gln Arg Pro 
        115                 120                 125             


Lys Ser Ala Thr Ala Gln Arg Leu Phe Asp Arg Leu Arg Ser Leu Thr 
    130                 135                 140                 


Ala Pro His Arg Leu Val Leu Leu Lys Ser Ala Ala Glu Trp Ile Ile 
145                 150                 155                 160 


Ala Arg Tyr Gln Arg Gly Met Glu Asn Trp Gln Arg Gln Phe Ala Glu 
                165                 170                 175     


Trp Gln Arg Glu Lys Glu Glu Trp Glu Ala Ala His Pro Asn Leu Thr 
            180                 185                 190         


Pro Glu Val Arg Asp Ala Phe Thr Arg Val Phe Lys Asn Leu Phe Glu 
        195                 200                 205             


Asn Pro Asp Gly Asp Gly Lys Ile Gly Val Arg Arg Lys Asn Pro Arg 
    210                 215                 220                 


Ile Cys Ser Trp Glu Arg Leu Lys Leu Asn Lys Asp Asn Cys Val Tyr 
225                 230                 235                 240 


Ala Gly Gln Lys Gly His Gly Pro Leu Cys Trp Glu Phe Ser Lys Phe 
                245                 250                 255     


Val Lys Ala Gln Lys Asn Ala Gly Thr Ile Lys Thr Phe Phe Val Asp 
            260                 265                 270         


Val Ala Asn Lys Tyr Leu His Val Arg Arg Asn Leu Ser Lys Pro Gly 
        275                 280                 285             


Val Lys Leu Lys Lys Ser Pro Arg Gln Glu Ala Phe Lys Arg Leu Tyr 
    290                 295                 300                 


Asn Gln Lys Gly Met Glu Lys Ala Arg Asn Trp Phe Thr Asp Ala Trp 
305                 310                 315                 320 


Ser Gly Tyr Leu Thr Ala Leu Asn Leu Asn Glu Lys Thr Ile Leu Asp 
                325                 330                 335     


His Gly Cys Leu Lys His Cys Gly Ala Ile Gly Ala Glu Phe Glu Lys 
            340                 345                 350         


Ser Leu Cys Gln Phe Asn Pro His Thr His Leu Cys Val Gln Tyr Arg 
        355                 360                 365             


Asn Ala Leu Glu Ser Leu Glu Pro Ala Ile Arg Glu Leu Glu Gly Asp 
    370                 375                 380                 


Tyr Arg Glu Trp Arg Arg Leu Phe Leu Ala Pro Pro Arg Lys Pro Ser 
385                 390                 395                 400 


Phe Arg Tyr Pro Ser Ser Arg Arg Leu Pro Met Pro Lys Ile Phe Gly 
                405                 410                 415     


Glu His Phe His Gln Ile Asp Phe Asp Gln Ser Ile Leu Arg Leu Arg 
            420                 425                 430         


Leu Glu Asp Met Ala Glu Gly Glu Trp Ile Glu Phe Gly Phe Lys Pro 
        435                 440                 445             


Trp Pro Lys Asp Tyr Arg Pro Gly Lys Asp Glu Val Arg Val Thr Ser 
    450                 455                 460                 


Val His Val Asn Phe His Gly Asn Arg Met Arg Ala Gly Phe His Phe 
465                 470                 475                 480 


Glu Ala Pro Ala Lys Pro Ser Arg Phe Ala Cys Thr Gln Asp Glu Leu 
                485                 490                 495     


Asp Asp Leu Arg Ser Lys Gln Phe Pro Arg Gln Ser Gln Asp Arg Gln 
            500                 505                 510         


Leu Leu Glu Val Ala Arg Arg Arg Leu Leu Glu Ser Phe Asp Gly Met 
        515                 520                 525             


Leu Glu Ser Asp Leu Arg Ile Leu Ala Val Asp Leu Gly Glu Lys Gly 
    530                 535                 540                 


Ala Ala Ala Ala Val Tyr Gln Gly His Gly His Glu Ala Asp Val Ala 
545                 550                 555                 560 


Ile Pro Ile Val Lys Ile Asp Arg Leu Tyr Asp His Val Pro Asp Val 
                565                 570                 575     


Leu Asp Val Glu Ser Ala Arg Val Pro Pro Pro Lys Phe Asp Asp Ser 
            580                 585                 590         


Arg Asp Pro Arg Gly Val Arg Lys Glu His Val Gly Arg His Leu Gly 
        595                 600                 605             


Gln Leu Gln Arg Gly Ala Gln Thr Leu Ala Gln His Arg Gln Gln Asp 
    610                 615                 620                 


Glu Ser Ala Pro Ala Ala Leu Arg Arg His Asp Phe Arg Ser Leu Thr 
625                 630                 635                 640 


Arg His Ile Arg Trp Met Ile Arg Asp Trp Thr Arg His Asn Ala Ala 
                645                 650                 655     


Gln Ile Thr Ala Ala Ala Glu Thr His Arg Cys His Leu Ile Val Phe 
            660                 665                 670         


Glu Ser Leu Arg Gly Phe Lys Pro Arg Gly Tyr Asp Gln Met Asp Phe 
        675                 680                 685             


Ala Gln Lys Ala Arg Leu Ala Phe Phe Ala Tyr Gly Arg Val Arg Arg 
    690                 695                 700                 


Lys Val Val Glu Lys Ala Val Glu Arg Gly Leu Arg Val Val Thr Val 
705                 710                 715                 720 


Pro Tyr Gly Phe Thr Ser Gln Ile Cys Ser Glu Cys Gly His Arg Gln 
                725                 730                 735     


Arg Asn Lys Gly Arg Leu Arg Lys Asn Lys Tyr Gln Arg Arg Phe Val 
            740                 745                 750         


Cys Glu Cys Gly Glu Pro Lys Lys Ser Ala Asn Lys Thr Ala Ala Pro 
        755                 760                 765             


Asp Arg Ser Ala Thr Val Ser Pro Cys Thr Cys Arg Leu Gln Leu Gly 
    770                 775                 780                 


Ser Asp Val Asn Ala Ala Arg Val Leu Ala Arg Val Phe Trp Asp Glu 
785                 790                 795                 800 


Ile Val Leu Pro Thr Arg Glu Glu Met Arg Glu Pro Ala Val Asp Ser 
                805                 810                 815     


Ala Pro Pro Ser Lys 
            820     


<210> 69
<211> 797
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12g sequence"

<400> 69
Met Cys Leu Cys Thr Leu Ser Gly Arg Thr Arg Gln Glu Glu Glu Ile 
1               5                   10                  15      


Ile Gly Ser Thr Gln Tyr Thr Glu Ala Arg Ser Leu Val Arg Arg Ile 
            20                  25                  30          


Arg Arg Pro Arg Gly Glu Ser Arg Arg Gln Phe Lys Ser Asn Val Leu 
        35                  40                  45              


Leu Leu Arg Arg His Phe Glu Gln Phe Asn Val Asp Ala Ser Glu Ile 
    50                  55                  60                  


Cys Gln Trp Leu Met Gly Ile Arg Pro Gly Gly Arg His Ala Asp Glu 
65                  70                  75                  80  


Ser Thr Gly Pro Phe Trp Glu Phe Phe Leu Asp Pro Gly Arg Phe Leu 
                85                  90                  95      


Arg Glu Thr Gly Arg Gly Pro Glu Asp Ala Asp Glu Arg Ile Asp Ala 
            100                 105                 110         


Tyr Arg Arg Ile Ala Phe Asp Val Val Ala Gly Ile Glu Asp Glu Ser 
        115                 120                 125             


Arg Met Ser Asp Pro Ser Ile Pro Arg Gln Ile Val Glu Ser Leu His 
    130                 135                 140                 


Ala Val Ser Met Ala Thr Arg Thr Glu Ser Ala Arg Arg Leu Phe Glu 
145                 150                 155                 160 


Arg Leu Ala Gly Leu Glu Pro Ser His Arg Gln Ile Leu Leu Lys Ala 
                165                 170                 175     


Ala Ala Glu Trp Ile Val Ser Arg Tyr Trp Arg Ser Val Gln Gly Trp 
            180                 185                 190         


Pro Asp Arg Tyr Lys His Trp Ser Asp Glu Lys Glu Glu Trp Glu Lys 
        195                 200                 205             


Ala His Pro Arg Leu Thr Glu Ser Leu Arg Glu Glu Phe Thr Gly Ile 
    210                 215                 220                 


Phe Arg Asp Leu Gly Ile Arg Arg Lys Lys Pro Arg Val Cys Pro Trp 
225                 230                 235                 240 


Glu Arg Leu Glu Lys Gly Met Asp Asn Cys Met Tyr Ala Gly Glu Arg 
                245                 250                 255     


Ile Lys Val Gly Tyr Ser Arg Gln Ser His Ser Gln Leu Cys Ala Lys 
            260                 265                 270         


Tyr Glu Arg Phe Ser Tyr Lys Gln Arg Gln Arg Thr Lys Ser Gly Lys 
        275                 280                 285             


Asn Phe Lys Ser Tyr Phe Val Lys Asn Ala Glu Leu Tyr Leu Lys Leu 
    290                 295                 300                 


Arg Arg Lys Asn Arg Ser Leu Ile Lys Lys Asp Val Met Lys Leu Phe 
305                 310                 315                 320 


Arg Lys Lys Val Pro Gln Ala Leu Trp Phe Glu Lys Ala Trp Asp Glu 
                325                 330                 335     


Tyr Leu Lys Ala Leu Gly Val Asp Glu Ala Thr Leu Thr Lys Asp Gly 
            340                 345                 350         


Lys Leu Pro His Cys Thr Gln Phe Ala Asp Asp Lys Glu Cys Leu Phe 
        355                 360                 365             


Asn Arg His Thr Glu Leu Cys Leu Gln Tyr Arg Glu Arg Leu Leu Arg 
    370                 375                 380                 


Leu Pro His Leu Gln Glu Leu Glu Gln Leu Tyr Arg Glu Trp Arg Asp 
385                 390                 395                 400 


Lys Tyr Leu Ser Gly Pro Arg Arg Pro Ser Leu Arg Tyr Pro Ser Lys 
                405                 410                 415     


Arg Thr Leu Pro Met Pro Lys Val Phe Gly Arg Gly Tyr Phe Cys Ala 
            420                 425                 430         


Asp Phe Thr Asn Ser Leu Leu Asp Leu Arg Leu Glu Gly Met Gly Glu 
        435                 440                 445             


Gly Asp Phe Val Arg Phe Gly Phe Ala Pro Trp Pro Ala Asp Tyr Asp 
    450                 455                 460                 


Ala Gln Pro Ser Asp Ala Thr Val Thr Ser Val His Ile His Phe Val 
465                 470                 475                 480 


Gly Thr Arg Ala Arg Ala Gly Phe Arg Phe Gln Ala Pro His Lys Thr 
                485                 490                 495     


Ser Arg Phe Ala Ser Ser Gln Asp Glu Ile Asp Asp Leu Arg Ser Arg 
            500                 505                 510         


Lys Phe Pro Arg Ala Ala Gln Asp Gly Glu Phe Leu Asp Ala Ala Arg 
        515                 520                 525             


Lys Leu Leu Leu Glu Ser Phe Thr Gly Asp Ala Glu Arg Glu Met Lys 
    530                 535                 540                 


Leu Leu Ala Val Asp Leu Gly Asp Arg Gly Ala Gly Ala Ala Val Phe 
545                 550                 555                 560 


Glu Gly Arg Cys Phe Lys Glu Ala Met Pro Leu Lys Ile Ile Lys Thr 
                565                 570                 575     


Asp Thr Leu Ile Asp Lys Pro Pro Pro Val Thr Lys Thr Pro Arg Lys 
            580                 585                 590         


Gly Lys Pro Gly Lys Arg Glu Ser Lys Arg Ala Arg Gly Leu Asp Lys 
        595                 600                 605             


Tyr His Val Ala Arg His Leu Asp Thr Trp Arg Lys Gly Ala Arg Lys 
    610                 615                 620                 


Ile Ala Glu Arg Arg Ala Lys Gly Glu Ala Asp Pro Val Lys Leu Gly 
625                 630                 635                 640 


Ala His Asp Met Arg Ser Leu Ser Leu His Val Arg Trp Met Ile Arg 
                645                 650                 655     


Asp Trp Val Arg Leu Asn Ala Ser Gln Ile Ile Lys Thr Ala Glu Ser 
            660                 665                 670         


His Lys Thr Asp Leu Ile Val Leu Glu Ser Leu Arg Gly Phe Ser Ala 
        675                 680                 685             


Pro Gly Tyr His Lys Leu Asp Asp Glu Lys Lys Arg Thr Leu Ala Phe 
    690                 695                 700                 


Phe Ala Tyr Gly Arg Ile Arg Arg Lys Leu Thr Glu Lys Ala Val Glu 
705                 710                 715                 720 


Arg Gly Met Arg Val Val Val Ala Pro Tyr Leu Arg Ser Ser Gln Val 
                725                 730                 735     


Cys Ala Glu Cys Gly Arg Glu Gln Ile Asp Arg Asn Lys Leu Met Lys 
            740                 745                 750         


Asp Lys Arg Lys Arg Arg Phe Ile Cys Glu Tyr Ser Asp Cys Thr Trp 
        755                 760                 765             


Gln Cys Asp Ser Asp Gln Asn Ala Ala Cys Val Leu Gly Arg Val Phe 
    770                 775                 780                 


Trp Gly Glu Ile Glu Leu Pro Ser Glu Arg Lys Lys Asp 
785                 790                 795         


<210> 70
<211> 830
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12g sequence"

<400> 70
Met His Pro Ser Arg Tyr Lys Thr Ala Arg Thr Leu Val Arg Arg Leu 
1               5                   10                  15      


Cys Arg Leu Pro Gly Glu Asp Arg Ser Ala Phe Arg Ser Lys Val Gly 
            20                  25                  30          


Leu Leu Arg Gly His Phe Glu Gln Phe Asn Val Asp Val Ser Glu Leu 
        35                  40                  45              


Cys Gln Trp Leu Met Ser Leu Arg Lys Arg Asn Lys Val Pro Glu Asn 
    50                  55                  60                  


Pro Ala Thr Phe Gly Ala Leu Gly Asp Phe Leu Leu Gln Pro Gly Leu 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Asp Glu Lys Glu Ala Asp Arg Leu Arg Leu Ala 
                85                  90                  95      


Val Phe Asp Ala Val Ala Gly Phe Arg Met Leu Glu Asp Arg Leu Ala 
            100                 105                 110         


Ala Ser Ile Pro Ala Ser Leu Ser Asp Ala Ile Arg Asp Glu Ala Val 
        115                 120                 125             


Phe Leu Ala Gly Val Arg Ala Ala Gly Lys Pro Ser Gly Leu Ala Arg 
    130                 135                 140                 


Val Leu Ala Arg Leu Glu Ala Cys Ala Pro Ala Gln Arg Leu Val Leu 
145                 150                 155                 160 


Leu Lys Ser Ala Ala Glu Trp Ile Val Ala Arg Phe Leu Arg Gly Thr 
                165                 170                 175     


Glu Asn Trp Met Arg Gln Arg Ala Glu Trp Glu Lys Glu Lys Ala Ala 
            180                 185                 190         


Trp Glu Ala Ala His Pro His Leu Thr Pro Glu Val Arg Ala Gln Phe 
        195                 200                 205             


Asn Lys Ile Phe Glu Ser Leu His Asp Pro Glu Asn Ser Gly Lys Pro 
    210                 215                 220                 


Gly Val Ser Arg Lys Asn Pro Arg Ile Cys Pro Trp Asp Arg Leu Lys 
225                 230                 235                 240 


Gln Asn Leu Asp Asn Cys Cys Tyr Gly Glu Lys Gly His Ser Ala Leu 
                245                 250                 255     


Cys Trp Arg Tyr Gln Asp Phe Leu Lys Gln Arg Met Gly Glu Asn Arg 
            260                 265                 270         


Arg Asp Lys Lys Asn Phe Ser Ala Thr Ala Met Asp Leu Ala Gln Ile 
        275                 280                 285             


Cys Arg Glu Trp Lys Ile Gln His Ser Arg Asn Ala Leu Asn Asn Pro 
    290                 295                 300                 


Arg Val Leu Asp Arg Leu Phe Ala Glu His Glu Arg Arg Lys Gln Asp 
305                 310                 315                 320 


Lys Thr Lys Lys Glu Ser Arg Ser Pro Lys Pro Arg Gln Gly Gly Tyr 
                325                 330                 335     


Lys Ala Asn Pro Lys Ala Asp Tyr Leu Arg Ser Phe Lys Ala His Trp 
            340                 345                 350         


Lys Ala Tyr Leu Glu His Met Lys Leu Asn Asp Thr Thr Val Leu Glu 
        355                 360                 365             


Arg Gly Cys Leu Pro His Cys Leu Ser Ile Lys Lys Asn Gly Lys Glu 
    370                 375                 380                 


Ser Thr Cys Lys Trp Asn Lys His Thr Glu Leu Cys Leu Glu Tyr Lys 
385                 390                 395                 400 


Arg Ser Leu Ala Pro Leu Pro Asp Ser Val Leu Glu Leu Glu Pro Glu 
                405                 410                 415     


Tyr Arg Glu Trp Arg Arg Leu Tyr Leu His Gly Pro Gly Arg Pro His 
            420                 425                 430         


Phe Arg Tyr Pro Ser Ala Gly Glu Leu Pro Leu Pro Lys Val Phe Gly 
        435                 440                 445             


Glu Gly Phe His Gln Val Asp Leu Asp Arg Ser Ile Val Arg Leu Arg 
    450                 455                 460                 


Leu Glu Gly Ala Ala Glu Gly Glu Trp Leu Glu Phe Gly Phe Ile Pro 
465                 470                 475                 480 


Trp Pro Arg Gly Tyr Gln Pro Ser Arg Arg Glu Val Leu Ile Thr Ser 
                485                 490                 495     


Val Gln Val His Phe Val Gly Thr Arg Pro Arg Ala Gly Phe Arg Phe 
            500                 505                 510         


Asp Val Ser His Arg Thr Ser Arg Phe Gly Cys Ser Gln Asp Glu Leu 
        515                 520                 525             


Asp Glu Leu Arg Ser Arg Arg Tyr Pro Arg Gln Ala Gln Asp Lys Glu 
    530                 535                 540                 


Phe Leu Ala Ala Ala Arg Ala Gln Leu Ile Gln Thr Phe Glu Gly Gly 
545                 550                 555                 560 


Glu Gly Ala Ala Arg Gln Gln Met Arg Val Met Ser Val Asp Leu Gly 
                565                 570                 575     


Glu Gly Gly Ala Cys Ala Ser Ile Tyr Glu Gly Arg Thr His Gln Lys 
            580                 585                 590         


Asp Glu Ser Leu Lys Val Ile Lys Ile Asp Arg Arg Tyr Asp Gln His 
        595                 600                 605             


Pro Glu Val Leu Glu Lys Asp Val Gly Ala Ala Lys Pro Gln Lys Phe 
    610                 615                 620                 


Glu Lys Ser Asp Pro Arg Gly Val Arg Lys Glu His Val Ala Arg His 
625                 630                 635                 640 


Leu Asn Arg Ile Ala Ala Gly Ala Ser Ala Ile Ala Glu His Arg Arg 
                645                 650                 655     


Lys Glu Arg Ser Asp Ala Glu Cys Ser Val Gly Glu Leu Gln Glu His 
            660                 665                 670         


Asp Phe Arg Ser Leu Lys Arg His Ile Ala Trp Met Ile Arg Asp Trp 
        675                 680                 685             


Val Arg Leu Asn Ala Ala Gln Ile Ile Asp Val Ala Lys Gln His Cys 
    690                 695                 700                 


Cys Asp Leu Ile Val Phe Glu Ser Gln Arg Gly Phe Arg Leu Pro Gly 
705                 710                 715                 720 


Tyr Asp Glu Leu Asp Arg Gly Lys Lys Gln Arg Phe Ala Ile Leu Ala 
                725                 730                 735     


Phe Gly Arg Ile Arg Arg Lys Val Val Glu Lys Ala Val Glu His Gly 
            740                 745                 750         


Met Arg Val Val Thr Val Pro Tyr Phe Ala Ser Ser Gln Val Cys Ser 
        755                 760                 765             


Ala Cys Lys Arg Val Gln Glu Asn Arg Gly Ser Trp Arg Glu Asn Lys 
    770                 775                 780                 


Lys Lys Arg Val Phe Ala Cys Glu Phe Cys Lys Leu Lys Leu Asn Ser 
785                 790                 795                 800 


Asp Ala Asn Ala Ser Arg Val Leu Ala Arg Val Phe Trp Gly Glu Ile 
                805                 810                 815     


Glu Leu Pro Glu Pro Thr Arg Ala His Leu Pro Ser Lys Ala 
            820                 825                 830 


<210> 71
<211> 864
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      cas12g sequence"

<400> 71
Met Pro Val Ser Arg Tyr Ser Glu Ser Arg Thr Leu Val Arg Pro Leu 
1               5                   10                  15      


Ala Arg Leu Pro His Glu Glu Arg Gln Asp Val Thr Pro Lys Val Ala 
            20                  25                  30          


Arg Leu Arg Arg His Phe Glu Arg Phe Asn Val Asp Val Ala Glu Leu 
        35                  40                  45              


Cys Gln Trp Leu Met Gly Leu Arg Asn Gln Phe Gly Pro Lys Glu Ser 
    50                  55                  60                  


Pro Ala Ser Phe Gly Pro Leu Gly Asp Phe Leu Ile Glu Pro Ala Leu 
65                  70                  75                  80  


Asp Asn Ile Asp Ala Asp Glu Thr Glu Arg Asp Arg Trp Arg Leu Ala 
                85                  90                  95      


Val Phe Asp Ala Val Ala Gly Phe Arg Pro Ile Arg Gly Leu Gly Asp 
            100                 105                 110         


His Pro Val Pro Asp Thr Leu Arg Leu Ala Met Gln Gln Ala Ala Ser 
        115                 120                 125             


Leu Ser Pro Thr Pro Thr Thr Ala Arg Leu Leu Glu Arg Leu Arg Pro 
    130                 135                 140                 


Leu Ser Pro Ala His Arg Leu Val Leu Leu Lys Ser Ala Ala Glu Trp 
145                 150                 155                 160 


Ile Val Ala Arg Tyr Gln Arg Gly Met Glu Asn Trp Val Ile Gln His 
                165                 170                 175     


Ala Ala Trp His Lys Glu Lys Glu Ala Trp Glu Arg Glu His Pro Ala 
            180                 185                 190         


Leu Thr Pro Ala Val Arg Glu Arg Phe Thr Ala Leu Tyr Lys Gln Leu 
        195                 200                 205             


Ser Asp Ser Lys Pro Thr Asp Arg Pro Val Ser Arg Arg Lys Asn Pro 
    210                 215                 220                 


Arg Ile Cys Glu Trp Glu Arg Leu Arg Gln Asn Ile Asp Asn Cys Cys 
225                 230                 235                 240 


Tyr Ala Gly Glu Lys Gly His Gly Pro Leu Cys Arg Lys Tyr Ala Asn 
                245                 250                 255     


Phe Val Lys Ala Arg Lys Ala Val Asp Gly Lys Phe Asn Asp Leu Leu 
            260                 265                 270         


Phe Trp Asp Thr Ala Thr Ser Phe Ile Ala Leu Cys Arg Lys Phe Asn 
        275                 280                 285             


Val Thr Arg Ala Arg Asn Ala Leu Gln Ser Gln Leu Asp Ala Leu Phe 
    290                 295                 300                 


Ala Glu Asp Gln Arg Arg Lys Ala Glu Arg Asp Gln Ala Lys Gly Arg 
305                 310                 315                 320 


Gln Pro Arg Pro Leu His Pro Gln Ala Ala Ala Arg Ala Lys Ser Asp 
                325                 330                 335     


Phe Leu Arg Ile Phe Lys Asp Gly Trp Asn Ala Tyr Leu Ser Ala Met 
            340                 345                 350         


Gly Leu Asn Asp Ser Thr Ala Ile Glu Lys Gly Arg Leu Pro His Cys 
        355                 360                 365             


Gln Lys Ile Gly Gly Thr Phe Glu Asn Ser Lys Cys Glu Trp Asn Pro 
    370                 375                 380                 


His Thr Asp Leu Cys His Gln Tyr Arg Arg Leu Ala Gly Gln Leu Asp 
385                 390                 395                 400 


Asp Ala Thr Leu Ala Leu Glu Lys Asp Tyr Arg Glu Trp Arg Arg Leu 
                405                 410                 415     


Tyr Leu Ala Gly Pro Arg Lys Pro Ser Phe Gln Tyr Pro Ser Ser Arg 
            420                 425                 430         


Asp Leu Pro Met Pro Lys Ile Phe Gly Ala Gly Phe Phe Glu Leu Asp 
        435                 440                 445             


Met Asp Arg Ser Ile Leu Arg Leu Arg Leu Asp Asp Met Val Glu Gly 
    450                 455                 460                 


Glu Trp Leu Glu Phe Gly Phe Lys Pro Trp Pro Arg Glu Tyr Thr Pro 
465                 470                 475                 480 


Ser Arg Ala Gln Val Ala Arg Pro Gly Arg Ile Thr Ser Val His Val 
                485                 490                 495     


Asn Phe Ile Gly Ser Arg Cys Arg Val Gly Phe Arg Phe Glu Ala Pro 
            500                 505                 510         


His Ala Gly Ser Arg Phe Gly Cys Ser Gln Asp Glu Ile Asp Gln Leu 
        515                 520                 525             


Arg Arg Asp His Pro Arg Glu Arg Asp Asp Gln Pro Phe Leu Glu Ala 
    530                 535                 540                 


Ala Arg Lys Arg Leu Val Glu Thr Phe Ala Gly Asp Ala Arg Arg Asp 
545                 550                 555                 560 


Leu Arg Leu Leu Ala Val Asp Val Gly Glu Lys Gly Cys Cys Ala Ala 
                565                 570                 575     


Val Tyr Gln Gly Thr Arg Tyr Val Ala Asp Ala Leu Leu Pro Ile Ile 
            580                 585                 590         


Lys Ile Asn Gln Leu Tyr Thr Glu Pro Pro Thr Glu Leu Lys Pro Asp 
        595                 600                 605             


Ser His Asn Arg Pro Ala Pro Asp Arg Arg Pro Phe Asn Asp Glu Lys 
    610                 615                 620                 


Asp Pro Arg Asp Pro Arg Gly Val Arg Lys Glu His Val Ala Arg His 
625                 630                 635                 640 


Leu Lys Arg Met Ala Asp Lys Ala Pro Glu Val Ala Ala Tyr Arg Leu 
                645                 650                 655     


Ala Gln Arg Glu Lys Ala Ala Pro Ser Pro Ser Ala Ser Pro Pro Pro 
            660                 665                 670         


Val Thr Leu Gly Val His Asp Phe Arg Arg Leu Lys Arg His Val Thr 
        675                 680                 685             


Trp Met Ile Arg Asp Trp Ala Arg His Asn Ala Ala Arg Ile Val Ala 
    690                 695                 700                 


Glu Ala Gln Arg His Gly Cys Asp Leu Ile Val Phe Glu Ser His Arg 
705                 710                 715                 720 


Gly Arg Arg Pro Pro Gly Tyr His Glu Val Gly Asp Asp Ala Glu Arg 
                725                 730                 735     


Arg Lys Leu Asp Asn Ala Thr Phe Ala Phe Gly Arg Ile Arg Arg Lys 
            740                 745                 750         


Val Thr Glu Lys Ala Val Glu Arg Gly Leu Arg Val Val Thr Val Pro 
        755                 760                 765             


Tyr His Cys Ser Ser Lys Val Cys Ser Arg Cys Gly Arg Leu Gln Glu 
    770                 775                 780                 


Asn Asp Gly Leu Leu Arg Arg Asn Lys Lys Glu Arg Lys Phe Ile Cys 
785                 790                 795                 800 


Glu Gln Cys Lys Phe Glu Thr Asn Ser Asp Gly Asn Ala Ala Arg Val 
                805                 810                 815     


Leu Ala Arg Val Phe Trp Gly Glu Ile Met Leu Pro Ser Pro Glu Glu 
            820                 825                 830         


Arg Arg Lys Lys Arg Glu Gly Ser Gly Gly Arg Ser Pro Thr Pro Ala 
        835                 840                 845             


Asn Pro Gly Gly Leu Val Asp Ala Pro Pro Ser Arg Arg Asn Leu Arg 
    850                 855                 860                 


<210> 72
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 72
tgaaaatagg acctgagcg                                                    19


<210> 73
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 73
acacctagtc atgattgca                                                    19


<210> 74
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 74
ccaatagaat gatgccaaca ggcgatagac gtgccacatg c                           41


<210> 75
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 75
gattgatgtt caacaatggg gtttcattac catggacttg acaat                       45


<210> 76
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 76
gaaattaata cgactcacta tagggaagtg tctgaagcag tggaaaa                     47


<210> 77
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 77
gatttagact accccaaaaa cgaaggggac taaaacgatc atggttgctt tgtaggttac       60

ctgt                                                                    64


<210> 78
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 78
gcttctacgc agaaggga                                                     18


<210> 79
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 79
gtgacagttt ggccttgt                                                     18


<210> 80
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 80
tactgctgcc tggagttgaa ttcctcttct cgttcctcat c                           41


<210> 81
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 81
gctttgctgc tgcttgacag tgttgttggc ctttacca                               38


<210> 82
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 82
attgaaccag cttgagagca aa                                                22


<210> 83
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 83
gaaattaata cgactcacta tagggcttga actgttgcga ctacgt                      46


<210> 84
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 84
gatttagact accccaaaaa cgaaggggac taaaacggtg atgctgctct tgctttgctg       60

ctgc                                                                    64


<210> 85
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 85
ttgatgagct ggagcca                                                      17


<210> 86
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 86
caccctcaat gcagagtc                                                     18


<210> 87
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 87
gtgtgaccct gaagactcgg ttttagccac tgactcggat c                           41


<210> 88
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 88
cctccgtgat atggctcttc gtttttttct tacatggctc tggtc                       45


<210> 89
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 89
atgtggatgg ctgagttgtt                                                   20


<210> 90
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 90
gaattaatac gactcactat agggcatgct gagtactgga cctc                        44


<210> 91
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 91
gatttagact accccaaaaa cgaaggggac taaaacagtg gaggagtgtc ttttcaatta       60

cttg                                                                    64


<210> 92
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 92
caacgtgttg tagcttgtc                                                    19


<210> 93
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 93
accatcagta gataaaagtg ca                                                22


<210> 94
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 94
gaaccgccac acatgaccat ctatagatta gctaatgagt gtgct                       45


<210> 95
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 95
ggtggaacct catcaggaga tgtaacattg gccgtgacag                             40


<210> 96
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 96
ccacaactgc ttatgctaat agtgt                                             25


<210> 97
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 97
cgtttctata gattagctaa tgagt                                             25


<210> 98
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 98
ggcaattttg ttaccatcag t                                                 21


<210> 99
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 99
gaggttccac ctggtttaac atatagctca agtattgagt gaaatgg                     47


<210> 100
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 100
caggagatgc cacaactgct tatagataaa agtgcattaa cattgg                      46


<210> 101
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 101
taacatttgt caagctgtca cgg                                               23


<210> 102
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 102
atggcctcac ttgttctt                                                     18


<210> 103
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 103
taacattggc cgtgacag                                                     18


<210> 104
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 104
acttgagcac actcattagc taatcgctcg caaacataca acg                         43


<210> 105
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 105
gtcatgtgtg gcggttcact acactattag cataagcagt tg                          42


<210> 106
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 106
acggtgtgac aagctacaac a                                                 21


<210> 107
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 107
atgttaaacc aggtggaacc tcatc                                             25


<210> 108
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 108
gctcgcaaac atacaacg                                                     18


<210> 109
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 109
gcattaacat tggccgtg                                                     18


<210> 110
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 110
accatttcac tcaatacttg agcagtagct tgtcacaccg tt                          42


<210> 111
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 111
atatgttaaa ccaggtggaa cctcgcttga caaatgttaa aaacact                     47


<210> 112
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 112
tcaggagatg ccacaactgc ttat                                              24


<210> 113
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 113
cctaacatgc ttagaattat ggc                                               23


<210> 114
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 114
taacattggc cgtgacag                                                     18


<210> 115
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 115
acttgagcac actcattagc taatccactt gttcttgctc gca                         43


<210> 116
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 116
gtcatgtgtg gcggttcact cactattagc ataagcagtt gt                          42


<210> 117
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 117
gacaagctac aacacgttgt atgtt                                             25


<210> 118
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 118
taaaccaggt ggaacctcat ca                                                22


<210> 119
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 119
tgttcttgct cgcaaaca                                                     18


<210> 120
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 120
taacattggc cgtgacag                                                     18


<210> 121
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 121
actcaatact tgagcacact cattatacaa cgtgttgtag cttgtc                      46


<210> 122
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 122
atggtcatgt gtggcggttc ctattagcat aagcagttgt gg                          42


<210> 123
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 123
gttaaaccag gtggaacctc atc                                               23


<210> 124
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 124
caacgtgttg tagcttgtc                                                    19


<210> 125
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 125
accatcagta gataaaagtg ca                                                22


<210> 126
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 126
ggtttaacat atagtgaacc gccacgctaa tgagtgtgct caagt                       45


<210> 127
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 127
ggtggaacct catcaggaga tgtaacattg gccgtgacag                             40


<210> 128
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 128
ccacaactgc ttatgctaat agtgt                                             25


<210> 129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 129
gctaatgagt gtgctcaagt                                                   20


<210> 130
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 130
acttatcggc aattttgtta cc                                                22


<210> 131
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 131
cctgatgagg ttccacctgg tgagtgaaat ggtcatgtgt                             40


<210> 132
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 132
gatgccacaa ctgcttatgc tgtagataaa agtgcattaa cattgg                      46


<210> 133
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 133
taacatttgt caagctgtca cgg                                               23


<210> 134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 134
catggctttg agttgacatc                                                   20


<210> 135
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 135
acctgtaaaa ccccattgt                                                    19


<210> 136
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 136
atgtggcacg tctatcacat agatgaagta ttttgtgaaa ataggacc                    48


<210> 137
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 137
tccactgctt cagacactta tgctgaacat caatcataaa cggatt                      46


<210> 138
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 138
tgatgttcaa caatggggt                                                    19


<210> 139
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 139
ttaatcttca gttcatcacc aa                                                22


<210> 140
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 140
gctacatgtg cattaccatg gacttttaca ggtaacctac aaagcaa                     47


<210> 141
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 141
agttgtgatg caatcatgac taggtttata ggatattcaa tagtccagtc                  50


<210> 142
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 142
ccacgagtgc tttgttaagc g                                                 21


<210> 143
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 143
ccatgatctg tattgtcaag tc                                                22


<210> 144
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 144
gaactgggaa tttgtctgc                                                    19


<210> 145
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 145
cgtggacagc tagacaccta gcatggtaat gcacatgtag c                           41


<210> 146
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 146
gcgtgttgac tggactattg aatataacca tgtgttgaac ctttc                       45


<210> 147
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 147
atgaactgaa gattaatgcg gcttg                                             25


<210> 148
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 148
catcattcta ttggatttga ttacg                                             25


<210> 149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 149
tcaatagtcc agtcaacacg                                                   20


<210> 150
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 150
agatcatggt tgctttgtag gttacaatcc gtttatgatt gatgttca                    48


<210> 151
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 151
gtcaagtcca tggtaatgca catcttaaca aagcactcgt gg                          42


<210> 152
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 152
tgtgatgcaa tcatgactag gtgt                                              24


<210> 153
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 153
gtctataatc cgtttatgat tgatg                                             25


<210> 154
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 154
ccgcattaat cttcagttca t                                                 21


<210> 155
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 155
tacatgtgca ttaccatgga cttgaaacaa tggggtttta caggta                      46


<210> 156
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 156
agttgtgatg caatcatgac taggtttata ggatattcaa tagtccagtc                  50


<210> 157
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 157
cagatcatgg ttgctttgta ggt                                               23


<210> 158
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 158
agctgtccac gagtgcttt                                                    19


<210> 159
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 159
acacttatgc ctgttggc                                                     18


<210> 160
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 160
acacgcttaa caaagcact                                                    19


<210> 161
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 161
aggttacctg taaaacccca ttgtgatttg attacgtcta taatccgt                    48


<210> 162
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 162
aagcaaccat gatctgtatt gtcatagaca cctagtcatg attgc                       45


<210> 163
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 163
tggtaatgca catgtagcta gttgt                                             25


<210> 164
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 164
tgaaaatagg acctgagcg                                                    19


<210> 165
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 165
acacctagtc atgattgca                                                    19


<210> 166
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 166
ccaatagaat gatgccaaca ggcgatagac gtgccacatg c                           41


<210> 167
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 167
gattgatgtt caacaatggg gtttcattac catggacttg acaat                       45


<210> 168
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 168
aagtgtctga agcagtggaa aa                                                22


<210> 169
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 169
ggtaacctac aaagcaacca tgat                                              24


<210> 170
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 170
agtccatggt aatgcacat                                                    19


<210> 171
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 171
gggttaccaa tgtcgtgaa                                                    19


<210> 172
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 172
gcttaacaaa gcactcgtgg agtagctagt tgtgatgcaa tc                          42


<210> 173
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 173
gatgaactga agattaatgc ggcttgaact gggaatttgt ctgc                        44


<210> 174
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 174
tcaacacatg gttgttaaag ctgca                                             25


<210> 175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 175
atcagaggca cgtcaacatc                                                   20


<210> 176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 176
tcaccactac gaccgtactg                                                   20


<210> 177
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 177
agggctgttc aagttgaggc aaagatggca cttgtggctt ag                          42


<210> 178
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 178
acgttcggat gctcgaactg catgccttcg agttctgcta c                           41


<210> 179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 179
aacgcctttt tcaacttcta                                                   20


<210> 180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 180
agatggcact tgtggcttag                                                   20


<210> 181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 181
cgaagaagaa ccttgcggta                                                   20


<210> 182
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 182
gcagttcgag catccgaacg ttggcgtttt gcctcaactt g                           41


<210> 183
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 183
tcgaaggcat tcagtacggt cgactggtat ttcgcccaca tg                          42


<210> 184
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 184
ggtgagacac ttggtgtcct tgtc                                              24


<210> 185
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 185
cctcaacttg aacagccct                                                    19


<210> 186
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 186
acgaagaaga accttgcgg                                                    19


<210> 187
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 187
gccttcgagt tctgctacca gctcatcaaa cgttcggatg ct                          42


<210> 188
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 188
acggtcgtag tggtgagaca cttaagccac tggtatttcg cc                          42


<210> 189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 189
tgaccatgag gtgcagttcg                                                   20


<210> 190
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 190
tggtgtcctt gtccctcatg t                                                 21


<210> 191
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 191
cctcaacttg aacagccct                                                    19


<210> 192
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 192
tatggccacc agctcctt                                                     18


<210> 193
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 193
cgaccgtact gaatgccttc gacgttcgga tgctcgaact g                           41


<210> 194
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 194
gacacttggt gtccttgtcc ctagaagaac cttgcggtaa gc                          42


<210> 195
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 195
catgtgggcg aaataccagt g                                                 21


<210> 196
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 196
cttatcagag gcacgtcaa                                                    19


<210> 197
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 197
tacgaccgta ctgaatgc                                                     18


<210> 198
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 198
tcaagttgag gcaaaacgcc tcttaaagat ggcacttgtg g                           41


<210> 199
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 199
agccctatgt gttcatcaaa cgttcttcga gttctgctac ca                          42


<210> 200
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 200
tttttcaact tctactaag                                                    19


<210> 201
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 201
catcttaaag atggcacttg t                                                 21


<210> 202
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 202
agtgtctcac cactacga                                                     18


<210> 203
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 203
gtttgatgaa cacatagggc tgttggctta gtagaagttg aaaaagg                     47


<210> 204
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 204
gttcggatgc tcgaactgca ccgtactgaa tgccttcg                               38


<210> 205
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 205
caagttgagg caaaacg                                                      17


<210> 206
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 206
gatggcactt gtggctta                                                     18


<210> 207
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 207
aggacaccaa gtgtctca                                                     18


<210> 208
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 208
ccgaacgttt gatgaacaca tagggtagaa gttgaaaaag gcgt                        44


<210> 209
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 209
atgctcgaac tgcacctcat ccactacgac cgtactgaa                              39


<210> 210
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 210
gctgttcaag ttgaggcaaa                                                   20


<210> 211
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 211
gtagaagttg aaaaaggcgt t                                                 21


<210> 212
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 212
gaagaagaac cttgcggt                                                     18


<210> 213
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 213
accatgaggt gcagttcgag gcctcaactt gaacagcc                               38


<210> 214
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 214
agaactcgaa ggcattcagt acgaagccac tggtatttcg c                           41


<210> 215
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 215
tccgaacgtt tgatgaacac atag                                              24


<210> 216
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 216
gtcgtagtgg tgagacactt gg                                                22


<210> 217
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 217
tcaaacgttc ggatgctc                                                     18


<210> 218
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 218
ccagctcctt tattaccgt                                                    19


<210> 219
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 219
cgtactgaat gccttcgagt tctgaactgc acctcatggt c                           41


<210> 220
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 220
gtcgtagtgg tgagacactt ggacgaagaa gaaccttgcg                             40


<210> 221
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 221
gctaccagct caaccataac at                                                22


<210> 222
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 222
cttgtccctc atgtgggcga a                                                 21


<210> 223
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 223
tgttatggag tgtctcctac t                                                 21


<210> 224
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 224
ccaaccttag aatcaagatt gt                                                22


<210> 225
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 225
cgatttgtct gacttcatca cctctaaatg atctctgctt tactaatgtc                  50


<210> 226
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 226
ctccagggca aactggaaag caagctataa cgcagcct                               38


<210> 227
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 227
caacagaatc tattgttaga tttcc                                             25


<210> 228
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 228
agacattagt aaagcagaga tca                                               23


<210> 229
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 229
ttctcttcct gttccaagca taaacctttt ggtgaagttt ttaacg                      46


<210> 230
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 230
actgtgttgc tgattattct gtccaattta gtaggagaca ctccat                      46


<210> 231
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 231
ccgcatcatt ttccactttt aagtg                                             25


<210> 232
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 232
caacagaatc tattgttaga tttcc                                             25


<210> 233
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 233
agacattagt aaagcagaga tca                                               23


<210> 234
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 234
gttccaagca taaacagatg caaatcaaac ttgtgccctt ttgg                        44


<210> 235
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 235
actgtgttgc tgattattct gtccaattta gtaggagaca ctccat                      46


<210> 236
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 236
tgatctctgc tttactaatg tct                                               23


<210> 237
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 237
tgagattaga cttcctaaac aatc                                              24


<210> 238
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 238
cagtttgccc tggagcgatt atgcagattc atttgtaatt agagg                       45


<210> 239
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 239
taccagatga ttttacaggc tgcccaccaa ccttagaatc aaga                        44


<210> 240
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 240
acttttaagt gttatggagt gtc                                               23


<210> 241
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 241
ccaaccttag aatcaagatt gt                                                22


<210> 242
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 242
cgatttgtct gacttcatca cctcttccta ctaaattaaa tgatctctgc                  50


<210> 243
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 243
ctccagggca aactggaaag tccaagctat aacgcagc                               38


<210> 244
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 244
tgttatggag tgtctcctac t                                                 21


<210> 245
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 245
ccaccaacct tagaatcaag a                                                 21


<210> 246
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 246
gagcgatttg tctgacttca tcatgcttta ctaatgtcta tgcagat                     47


<210> 247
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 247
ggcaaactgg aaagattgct gatgttagaa ttccaagcta taacg                       45


<210> 248
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 248
gagttgattt ttgtggaaag g                                                 21


<210> 249
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 249
gttacaaacc agtgtgtgc                                                    19


<210> 250
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 250
agggacataa gtcacatgca agaagctatc atcttatgtc cttccctc                    48


<210> 251
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 251
acaagaaaag aacttcacaa ctgctttgaa acaaagacac cttca                       45


<210> 252
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 252
acaccatgag gtgctgact                                                    19


<210> 253
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 253
tgccatttgt catgatggaa aagc                                              24


<210> 254
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 254
gtgacttatg tccctgca                                                     18


<210> 255
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 255
acaattccta ttacaacatc acag                                              24


<210> 256
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 256
acgaggaaag tgtgcttttc cagaaaagaa cttcacaact gc                          42


<210> 257
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 257
gtttcaaatg gcacacactg gtacacaaat gtgttgtctg tag                         43


<210> 258
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 258
ccaatttaat agtgctattg gca                                               23


<210> 259
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 259
gcacttcagc ctcaactt                                                     18


<210> 260
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 260
gcattttggt tgaccacatc ttgaaaattc aagactcact ttcttcc                     47


<210> 261
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 261
gctttaaaca cgcttgttaa acaactgtca agacgtgaaa ggat                        44


<210> 262
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 262
gttttccaag tgcacttgct gt                                                22


<210> 263
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 263
acaagaaaag aacttcacaa ct                                                22


<210> 264
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 264
tgacaattcc tattacaaca tca                                               23


<210> 265
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 265
gtgccatttg aaacaaagac accttgctcc tgccatttgt cat                         43


<210> 266
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 266
acactggttt gtaacacaaa ggacagttac cagacacaaa tgtg                        44


<210> 267
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 267
cacgaggaaa gtgtgctttt ccat                                              24


<210> 268
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 268
gctattggca aaattcaaga c                                                 21


<210> 269
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 269
gcacttcagc ctcaactt                                                     18


<210> 270
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 270
agcttgtgca ttttggttga cctcactttc ttccacagca                             40


<210> 271
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 271
aacacgcttg ttaaacaact tagcttgtca agacgtgaaa ggat                        44


<210> 272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 272
cttatgtcct tccctcagtc                                                   20


<210> 273
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 273
tgtagtaatg atttgtggtt cat                                               23


<210> 274
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 274
gcaggagcag ttgtgaagtt ctgtagtctt cttgcatgtg actt                        44


<210> 275
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 275
tgtcatgatg gaaaagcaca ctcctttgtg ttacaaacca gtg                         43


<210> 276
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 276
cgtgaaggtg tctttgtttc aaatg                                             25


<210> 277
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 277
acacagaatg ttctctatga ga                                                22


<210> 278
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 278
cgtgaaagga tatcatttaa aacac                                             25


<210> 279
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 279
acttgctgtg gaagaaagtg agtattgcca accaatttaa tagtgc                      46


<210> 280
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 280
ttggaaaact tcaagatgtg gtcagcacca aaattggagc taag                        44


<210> 281
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 281
tgcacaagct ttaaacacgc ttgtt                                             25


<210> 282
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 282
tcaagactca ctttcttcca                                                   20


<210> 283
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 283
atgtctgcaa actttgaagt                                                   20


<210> 284
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 284
gcgtgtttaa agcttgtgca tttcagcaag tgcacttgga a                           41


<210> 285
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 285
tgatatcctt tcacgtcttg acaaactgcc tgtgatcaac cta                         43


<210> 286
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 286
ttgaggctga agtgcaaatt ga                                                22


<210> 287
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 287
acctcatggt gtagtcttct                                                   20


<210> 288
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 288
cacaaatgtg ttgtctgtag t                                                 21


<210> 289

<400> 289
000


<210> 290

<400> 290
000


<210> 291

<400> 291
000


<210> 292

<400> 292
000


<210> 293

<400> 293
000


<210> 294

<400> 294
000


<210> 295

<400> 295
000


<210> 296

<400> 296
000


<210> 297

<400> 297
000


<210> 298

<400> 298
000


<210> 299
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 299
atgacaaatg gcaggagcag tgcatgtgac ttatgtccct                             40


<210> 300
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 300
aagcacactt tcctcgtgaa ggtgtggttc ataaaaattc ctttg                       45


<210> 301
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 301
gtttcaaatg gcacacactg gtttg                                             25


<210> 302
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 302
tcgtgttgtt ttagatttca tct                                               23


<210> 303
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 303
ttgagtgaga gcggtgaa                                                     18


<210> 304
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 304
tccaccaaac gtaatgcggg caaactaaaa tgtctgataa tggac                       45


<210> 305
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 305
actggcagta accagaatgg agcagtatta ttgggtaaac cttg                        44


<210> 306
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 306
gtgcatttcg ctgattttgg g                                                 21


<210> 307
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 307
acgaacaaac taaaatgtct ga                                                22


<210> 308
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 308
ttgagtgaga gcggtgaa                                                     18


<210> 309
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 309
tgaatctgag ggtccaccaa aatggacccc aaaatcagc                              39


<210> 310
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 310
actggcagta accagaatgg agcagtatta ttgggtaaac cttg                        44


<210> 311
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 311
cgtaatgcgg ggtgcatttc                                                   20


<210> 312
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 312
gatttcatct aaacgaacaa act                                               23


<210> 313
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 313
gggaatttaa ggtcttcctt g                                                 21


<210> 314
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 314
agggtccacc aaacgtaatg catgtctgat aatggacccc a                           41


<210> 315
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 315
ggcgcgatca aaacaacgtc catgttgagt gagagcgg                               38


<210> 316
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 316
aaggtttacc caataatact gcgtc                                             25


<210> 317
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 317
acgaacaaac taaaatgtct ga                                                22


<210> 318
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 318
cgagggaatt taaggtcttc c                                                 21


<210> 319
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 319
ttactgccag ttgaatctga gggaccccaa aatcagcgaa at                          42


<210> 320
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 320
cgatcaaaac aacgtcggcc ttgccatgtt gagtgaga                               38


<210> 321
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 321
aaacgtaatg cggggtgc                                                     18


<210> 322
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 322
caaggtttac ccaataatac tgcgt                                             25


<210> 323
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 323
actaaaatgt ctgataatgg acc                                               23


<210> 324
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 324
ctcgagggaa tttaaggtct                                                   20


<210> 325
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 325
gttactgcca gttgaatctg aggccaaaat cagcgaaatg ca                          42


<210> 326
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 326
cgcgatcaaa acaacgtcgg ccatgttgag tgagagcg                               38


<210> 327
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 327
caccaaacgt aatgcgggg                                                    19


<210> 328
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 328
caaggtttac ccaataatac tgcgt                                             25


<210> 329
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 329
acgaacaaac taaaatgtct ga                                                22


<210> 330
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 330
cctcgaggga atttaaggt                                                    19


<210> 331
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 331
ttactgccag ttgaatctga gggatggacc ccaaaatcag c                           41


<210> 332
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 332
ggccccaagg tttacccaat cttccttgcc atgttgagt                              39


<210> 333
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 333
cgtaatgcgg ggtgcatttc                                                   20


<210> 334
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 334
aatactgcgt cttggttcac cg                                                22


<210> 335
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 335
caaactaaaa tgtctgataa tggac                                             25


<210> 336
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 336
ctcgagggaa tttaaggtct                                                   20


<210> 337
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 337
gttactgcca gttgaatctg aggcccaaaa tcagcgaaat gc                          42


<210> 338
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 338
ggccccaagg tttacccaat tccttgccat gttgagtg                               38


<210> 339
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 339
accaaacgta atgcggggt                                                    19


<210> 340
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 340
aatactgcgt cttggttcac c                                                 21


<210> 341
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 341
aacacaagct ttcggcag                                                     18


<210> 342
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 342
tctttgtcat ccaatttgat gg                                                22


<210> 343
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 343
cggccaatgt ttgtaatcag ttcccagaac aaacccaagg aaat                        44


<210> 344
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 344
gttcttcgga atgtcgcgca cctgtgtagg tcaaccac                               38


<210> 345
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 345
tgattagttc ctggtcccca aa                                                22


<210> 346
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 346
ttggcatgga agtcacacct                                                   20


<210> 347
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 347
aacacaagct ttcggcag                                                     18


<210> 348
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 348
ttggatcttt gtcatccaat t                                                 21


<210> 349
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 349
cggccaatgt ttgtaatcag ttcccagaac aaacccaagg aaat                        44


<210> 350
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 350
gttcttcgga atgtcgcgca tgatggcacc tgtgtagg                               38


<210> 351
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 351
tgattagttc ctggtcccca aa                                                22


<210> 352
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 352
ttggcatgga agtcacacct                                                   20


<210> 353
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 353
tccagaacaa acccaagg                                                     18


<210> 354
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 354
atgacttgat ctttgaaatt tgg                                               23


<210> 355
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 355
gcaatttgcg gccaatgttt gaaattttgg ggaccagga                              39


<210> 356
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 356
tggcatggaa gtcacacctt tccaatttga tggcacctg                              39


<210> 357
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 357
cgggaacgtg gttgacct                                                     18


<210> 358
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 358
aacacaagct ttcggcag                                                     18


<210> 359
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 359
gacttgatct ttgaaatttg gatct                                             25


<210> 360
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 360
tgcggccaat gtttgtaatc agccaaggaa attttgggga c                           41


<210> 361
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 361
tggcatggaa gtcacacctt atccaatttg atggcacct                              39


<210> 362
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 362
cgggaacgtg gttgacct                                                     18


<210> 363
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 363
aacacaagct ttcggcag                                                     18


<210> 364
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 364
tctttgtcat ccaatttgat gg                                                22


<210> 365
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 365
tgcggccaat gtttgtaatc agcagaacaa acccaaggaa at                          42


<210> 366
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 366
gttcttcgga atgtcgcgca cacctgtgta ggtcaacc                               38


<210> 367
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 367
tgattagttc ctggtcccca aa                                                22


<210> 368
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 368
ttggcatgga agtcacacct                                                   20


<210> 369
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 369
aacacaagct ttcggcag                                                     18


<210> 370
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 370
gatctttgtc atccaatttg atg                                               23


<210> 371
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 371
cggccaatgt ttgtaatcag ttccagaaca aacccaagga aat                         43


<210> 372
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 372
gttcttcgga atgtcgcgca cctgtgtagg tcaaccac                               38


<210> 373
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 373
tgattagttc ctggtcccca aa                                                22


<210> 374
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 374
ttggcatgga agtcacacct                                                   20


<210> 375
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 375
taacacaagc tttcggca                                                     18


<210> 376
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 376
gaaatttgga tctttgtcat cc                                                22


<210> 377
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 377
gcaatttgcg gccaatgttt gccaaggaaa ttttggggac                             40


<210> 378
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 378
gttcttcgga atgtcgcgca tttgatggca cctgtgtag                              39


<210> 379
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 379
cagttccttg tctgattagt tcctg                                             25


<210> 380
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 380
ttggcatgga agtcacacct                                                   20


<210> 381
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 381
aacacaagct ttcggcag                                                     18


<210> 382
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 382
ctttgaaatt tggatctttg tca                                               23


<210> 383
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 383
tgcggccaat gtttgtaatc agccaaggaa attttgggga c                           41


<210> 384
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 384
tggcatggaa gtcacacctt tccaatttga tggcacctg                              39


<210> 385
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 385
cgggaacgtg gttgacct                                                     18


<210> 386
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 386
aacacaagct ttcggcag                                                     18


<210> 387
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 387
agcaaaatga cttgatcttt ga                                                22


<210> 388
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 388
gcaatttgcg gccaatgttt aaggaaattt tggggaccag                             40


<210> 389
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 389
atggaagtca caccttcggg tctttgtcat ccaatttgat gg                          42


<210> 390
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 390
aacgtggttg acctacacag g                                                 21


<210> 391
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 391
gaaatctgct gctgaggc                                                     18


<210> 392
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 392
aaggtgtgac ttccatgc                                                     18


<210> 393
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 393
ggtttgttct ggaccacgtc taaacgtact gccactaaag c                           41


<210> 394
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 394
actgattaca aacattggcc gcgacattcc gaagaacgct                             40


<210> 395
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 395
gccgaaagct tgtgttacat tgtat                                             25


<210> 396
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 396
tcttctcgtt cctcatcac                                                    19


<210> 397
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 397
cttagaagcc tcagcagc                                                     18


<210> 398
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 398
tctagcagga gaagttcccc tagtagtcgc aacagttcaa gaa                         43


<210> 399
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 399
ctgcttgaca gattgaacca gcgtgacagt ttggccttgt t                           41


<210> 400
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 400
aaaatgtctg gtaaaggcca acaac                                             25


<210> 401
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 401
agtaggggaa cttctcctg                                                    19


<210> 402
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 402
ctgccgaaag cttgtgtt                                                     18


<210> 403
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 403
gctggttcaa tctgtcaagc agtagaatgg ctggcaatgg                             40


<210> 404
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 404
gccaacaaca acaaggccaa agtacgtttt tgccgagg                               38


<210> 405
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 405
gcaagagcag catcaccg                                                     18


<210> 406
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 406
agtaggggaa cttctcctg                                                    19


<210> 407
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 407
ctgccgaaag cttgtgtt                                                     18


<210> 408
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 408
gctggttcaa tctgtcaagc agtagaatgg ctggcaatgg                             40


<210> 409
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 409
aacaaggcca aactgtcact aacagtacgt ttttgccgag                             40


<210> 410
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 410
gcaagagcag catcaccg                                                     18


<210> 411
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 411
tcctcatcac gtagtcgc                                                     18


<210> 412
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 412
ggcttcttag aagcctcag                                                    19


<210> 413
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 413
ccagccattc tagcaggaga aaacagttca agaaattcaa ctcc                        44


<210> 414
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 414
ttgacagatt gaaccagctt gagacagcag atttcttagt gacagt                      46


<210> 415
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 415
gttcccctac tgctgcct                                                     18


<210> 416
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 416
gcaaaatgtc tggtaaaggc caaca                                             25


<210> 417
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 417
gcttctacgc agaaggga                                                     18


<210> 418
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 418
gtgacagttt ggccttgt                                                     18


<210> 419
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 419
ctactgctgc ctggagttga attcctcttc tcgttcctca tc                          42


<210> 420
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 420
gctttgctgc tgcttgacag tgttgttggc ctttacca                               38


<210> 421
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 421
cttgaactgt tgcgactacg t                                                 21


<210> 422
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 422
attgaaccag cttgagagca aa                                                22


<210> 423
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 423
gctgcaatcg tgctacaact                                                   20


<210> 424
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 424
tttgctctca agctggttca                                                   20


<210> 425
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 425
tgcgactacg tgatgaggaa cgttgccaaa aggcttctac gc                          42


<210> 426
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 426
tctcctgcta gaatggctgg catctgtcaa gcagcagcaa ag                          42


<210> 427
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 427
ttgactgccg cctctgc                                                      17


<210> 428
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 428
gatttagact accccaaaaa cgaaggggac taaaactctg gtaatttata attataatca       60

gcaa                                                                    64


<210> 429
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 429
gatttagact accccaaaaa cgaaggggac taaaacaaaa tcatctggta atttataatt       60

ataa                                                                    64


<210> 430
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 430
gatttagact accccaaaaa cgaaggggac taaaacctgg taatttataa ttataatcag       60

caat                                                                    64


<210> 431
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 431
gatttagact accccaaaaa cgaaggggac taaaacacac ttaaaagtgg aaaatgatgc       60

ggaa                                                                    64


<210> 432
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 432
gatttagact accccaaaaa cgaaggggac taaaacaaaa gtggaaaatg atgcggaatt       60

atat                                                                    64


<210> 433
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 433
gatttagact accccaaaaa cgaaggggac taaaacacac ttaaaagtgg aaaatgatgc       60

ggaa                                                                    64


<210> 434
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 434
gatttagact accccaaaaa cgaaggggac taaaactaaa agtggaaaat gatgcggaat       60

tata                                                                    64


<210> 435
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 435
gatttagact accccaaaaa cgaaggggac taaaacgaaa gattgctgat tataattata       60

aatt                                                                    64


<210> 436
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 436
gatttagact accccaaaaa cgaaggggac taaaactgcg ttatagcttg gaattctaac       60

aatc                                                                    64


<210> 437
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 437
gatttagact accccaaaaa cgaaggggac taaaacatta caaatgaatc tgcatagaca       60

ttag                                                                    64


<210> 438
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 438
gatttagact accccaaaaa cgaaggggac taaaactctg gtaatttata attataatca       60

gcaa                                                                    64


<210> 439
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 439
gatttagact accccaaaaa cgaaggggac taaaaccctg taaaatcatc tggtaattta       60

taat                                                                    64


<210> 440
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 440
gatttagact accccaaaaa cgaaggggac taaaacgcct gtaaaatcat ctggtaattt       60

ataa                                                                    64


<210> 441
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 441
gatttagact accccaaaaa cgaaggggac taaaacaaag tgtgcttttc catcatgaca       60

aatg                                                                    64


<210> 442
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 442
gatttagact accccaaaaa cgaaggggac taaaacgtgt gcttttccat catgacaaat       60

ggca                                                                    64


<210> 443
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 443
gatttagact accccaaaaa cgaaggggac taaaactggt tcataaaaat tcctttgtgt       60

taca                                                                    64


<210> 444
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 444
gatttagact accccaaaaa cgaaggggac taaaacattt gtggttcata aaaattcctt       60

tgtg                                                                    64


<210> 445
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 445
gatttagact accccaaaaa cgaaggggac taaaaccatt taaaacactt gaaattgcac       60

caaa                                                                    64


<210> 446
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 446
gatttagact accccaaaaa cgaaggggac taaaacaaac acttgaaatt gcaccaaaat       60

tgga                                                                    64


<210> 447
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 447
gatttagact accccaaaaa cgaaggggac taaaactctg tagtaatgat ttgtggttca       60

taaa                                                                    64


<210> 448
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 448
gatttagact accccaaaaa cgaaggggac taaaactgat ggaaaagcac actttcctcg       60

tgaa                                                                    64


<210> 449
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 449
gatttagact accccaaaaa cgaaggggac taaaacaagt gcacttggaa aacttcaaga       60

tgtg                                                                    64


<210> 450
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 450
gatttagact accccaaaaa cgaaggggac taaaaccatt taaaacactt gaaattgcac       60

caaa                                                                    64


<210> 451
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 451
gatttagact accccaaaaa cgaaggggac taaaacccat ttgaaacaaa gacaccttca       60

cgag                                                                    64


<210> 452
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 452
gatttagact accccaaaaa cgaaggggac taaaacgtgc catttgaaac aaagacacct       60

tcac                                                                    64


<210> 453
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 453
gatttagact accccaaaaa cgaaggggac taaaacacaa gcgtgtttaa agcttgtgca       60

tttt                                                                    64


<210> 454
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 454
gatttagact accccaaaaa cgaaggggac taaaacgcac caaaattgga gctaagttgt       60

ttaa                                                                    64


<210> 455
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 455
gatttagact accccaaaaa cgaaggggac taaaactgaa attgcaccaa aattggagct       60

aagt                                                                    64


<210> 456
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 456
gatttagact accccaaaaa cgaaggggac taaaacccag tgtgtgccat ttgaaacaaa       60

gaca                                                                    64


<210> 457
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 457
gatttagact accccaaaaa cgaaggggac taaaacacaa accagtgtgt gccatttgaa       60

acaa                                                                    64


<210> 458
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 458
gatttagact accccaaaaa cgaaggggac taaaacccga cgttgttttg atcgcgcccc       60

actg                                                                    64


<210> 459
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 459
gatttagact accccaaaaa cgaaggggac taaaacgtgg ggcgcgatca aaacaacgtc       60

ggcc                                                                    64


<210> 460
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 460
gatttagact accccaaaaa cgaaggggac taaaacgaac gcagtggggc gcgatcaaaa       60

caac                                                                    64


<210> 461
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 461
gatttagact accccaaaaa cgaaggggac taaaacggca gtaaccagaa tggagaacgc       60

agtg                                                                    64


<210> 462
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 462
gatttagact accccaaaaa cgaaggggac taaaaccgcc ccactgcgtt ctccattctg       60

gtta                                                                    64


<210> 463
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 463
gatttagact accccaaaaa cgaaggggac taaaacgctg aagcgctggg ggcaaattgt       60

gcaa                                                                    64


<210> 464
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 464
gatttagact accccaaaaa cgaaggggac taaaacgaag cgctgggggc aaattgtgca       60

attt                                                                    64


<210> 465
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 465
gatttagact accccaaaaa cgaaggggac taaaaccaat ttgcccccag cgcttcagcg       60

ttct                                                                    64


<210> 466
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 466
gatttagact accccaaaaa cgaaggggac taaaaccccc cagcgcttca gcgttcttcg       60

gaat                                                                    64


<210> 467
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 467
gatttagact accccaaaaa cgaaggggac taaaacaaat tgcacaattt gcccccagcg       60

cttc                                                                    64


<210> 468
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 468
gatttagact accccaaaaa cgaaggggac taaaacaatg gcggtgatgc tgctcttgct       60

ttgc                                                                    64


<210> 469
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 469
gatttagact accccaaaaa cgaaggggac taaaacgcaa agcaagagca gcatcaccgc       60

catt                                                                    64


<210> 470
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 470
gatttagact accccaaaaa cgaaggggac taaaactgag agcaaaatgt ctggtaaagg       60

ccaa                                                                    64


<210> 471
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 471
gatttagact accccaaaaa cgaaggggac taaaacggtg atgctgctct tgctttgctg       60

ctgc                                                                    64


<210> 472
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 472
gatttagact accccaaaaa cgaaggggac taaaacgcag cagcaaagca agagcagcat       60

cacc                                                                    64


<210> 473
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 473
gatttagact accccaaaaa cgaaggggac taaaactgac aaatgttaaa aacactatta       60

gcat                                                                    64


<210> 474
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 474
gatttagact accccaaaaa cgaaggggac taaaacaatg ttaaaaacac tattagcata       60

agca                                                                    64


<210> 475
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 475
gatttagact accccaaaaa cgaaggggac taaaaccaaa tgttaaaaac actattagca       60

taag                                                                    64


<210> 476
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 476
gatttagact accccaaaaa cgaaggggac taaaactgac agcttgacaa atgttaaaaa       60

cact                                                                    64


<210> 477
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 477
gatttagact accccaaaaa cgaaggggac taaaaccgtg acagcttgac aaatgttaaa       60

aaca                                                                    64


<210> 478
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 478
gatttagact accccaaaaa cgaaggggac taaaactgtt gtagcttgtc acaccgtttc       60

tata                                                                    64


<210> 479
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 479
gatttagact accccaaaaa cgaaggggac taaaaccatc tcctgatgag gttccacctg       60

gttt                                                                    64


<210> 480
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 480
gatttagact accccaaaaa cgaaggggac taaaacctcc tgatgaggtt ccacctggtt       60

taac                                                                    64


<210> 481
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 481
gatttagact accccaaaaa cgaaggggac taaaactagc ataagcagtt gtggcatctc       60

ctga                                                                    64


<210> 482
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 482
gatttagact accccaaaaa cgaaggggac taaaactaga aacggtgtga caagctacaa       60

cacg                                                                    64


<210> 483
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 483
gatttagact accccaaaaa cgaaggggac taaaacacgg tgtgacaagc tacaacacgt       60

tgta                                                                    64


<210> 484
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 484
gatttagact accccaaaaa cgaaggggac taaaaccatc tcctgatgag gttccacctg       60

gttt                                                                    64


<210> 485
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 485
gatttagact accccaaaaa cgaaggggac taaaaccctg atgaggttcc acctggttta       60

acat                                                                    64


<210> 486
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 486
gatttagact accccaaaaa cgaaggggac taaaaccctg atgaggttcc acctggttta       60

acat                                                                    64


<210> 487
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 487
gatttagact accccaaaaa cgaaggggac taaaactgag gttccacctg gtttaacata       60

tagt                                                                    64


<210> 488
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 488
gatttagact accccaaaaa cgaaggggac taaaactgac aaatgttaaa aacactatta       60

gcat                                                                    64


<210> 489
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 489
gatttagact accccaaaaa cgaaggggac taaaacaatg ttaaaaacac tattagcata       60

agca                                                                    64


<210> 490
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 490
gatttagact accccaaaaa cgaaggggac taaaactgac agcttgacaa atgttaaaaa       60

cact                                                                    64


<210> 491
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 491
gatttagact accccaaaaa cgaaggggac taaaaccagc ttgacaaatg ttaaaaacac       60

tatt                                                                    64


<210> 492
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 492
gatttagact accccaaaaa cgaaggggac taaaacaatc aaatccaata gaatgatgcc       60

aaca                                                                    64


<210> 493
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 493
gatttagact accccaaaaa cgaaggggac taaaacatca aatccaatag aatgatgcca       60

acag                                                                    64


<210> 494
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 494
gatttagact accccaaaaa cgaaggggac taaaactaat caaatccaat agaatgatgc       60

caac                                                                    64


<210> 495
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 495
gatttagact accccaaaaa cgaaggggac taaaacacac gcttaacaaa gcactcgtgg       60

acag                                                                    64


<210> 496
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 496
gatttagact accccaaaaa cgaaggggac taaaaccgct taacaaagca ctcgtggaca       60

gcta                                                                    64


<210> 497
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 497
gatttagact accccaaaaa cgaaggggac taaaacccgc attaatcttc agttcatcac       60

caat                                                                    64


<210> 498
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 498
gatttagact accccaaaaa cgaaggggac taaaacacaa gccgcattaa tcttcagttc       60

atca                                                                    64


<210> 499
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 499
gatttagact accccaaaaa cgaaggggac taaaacacac ctagtcatga ttgcatcaca       60

acta                                                                    64


<210> 500
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 500
gatttagact accccaaaaa cgaaggggac taaaacagac acctagtcat gattgcatca       60

caac                                                                    64


<210> 501
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 501
gatttagact accccaaaaa cgaaggggac taaaaccagc tagacaccta gtcatgattg       60

catc                                                                    64


<210> 502
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 502
gatttagact accccaaaaa cgaaggggac taaaacacct acaaagcaac catgatctgt       60

attg                                                                    64


<210> 503
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 503
gatttagact accccaaaaa cgaaggggac taaaacacac gcttaacaaa gcactcgtgg       60

acag                                                                    64


<210> 504
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 504
gatttagact accccaaaaa cgaaggggac taaaacacgc ttaacaaagc actcgtggac       60

agct                                                                    64


<210> 505
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 505
gatttagact accccaaaaa cgaaggggac taaaactcac aactagctac atgtgcatta       60

ccat                                                                    64


<210> 506
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 506
gatttagact accccaaaaa cgaaggggac taaaaccaca actagctaca tgtgcattac       60

catg                                                                    64


<210> 507
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 507
gatttagact accccaaaaa cgaaggggac taaaacattt gattacgtct ataatccgtt       60

tatg                                                                    64


<210> 508
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 508
gatttagact accccaaaaa cgaaggggac taaaacgatc atggttgctt tgtaggttac       60

ctgt                                                                    64


<210> 509
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 509
gatttagact accccaaaaa cgaaggggac taaaaccaga tcatggttgc tttgtaggtt       60

acct                                                                    64


<210> 510
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 510
gatttagact accccaaaaa cgaaggggac taaaacgctt ttccactgct tcagacactt       60

atgc                                                                    64


<210> 511
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 511
gatttagact accccaaaaa cgaaggggac taaaacatta taggatattc aatagtccag       60

tcaa                                                                    64


<210> 512
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 512
gatttagact accccaaaaa cgaaggggac taaaacccaa ttataggata ttcaatagtc       60

cagt                                                                    64


<210> 513
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 513
gatttagact accccaaaaa cgaaggggac taaaacgctt taacaaccat gtgttgaacc       60

tttc                                                                    64


<210> 514
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 514
gatttagact accccaaaaa cgaaggggac taaaacgcag ctttaacaac catgtgttga       60

acct                                                                    64


<210> 515
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 515
gatttagact accccaaaaa cgaaggggac taaaaccttt aacaaccatg tgttgaacct       60

ttct                                                                    64


<210> 516
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 516
gatttagact accccaaaaa cgaaggggac taaaacacct catggtcatg ttatggttga       60

gctg                                                                    64


<210> 517
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 517
gatttagact accccaaaaa cgaaggggac taaaaccagc tcaaccataa catgaccatg       60

aggt                                                                    64


<210> 518
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 518
gatttagact accccaaaaa cgaaggggac taaaactggt catgttatgg ttgagctggt       60

agca                                                                    64


<210> 519
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 519
gatttagact accccaaaaa cgaaggggac taaaactgct accagctcaa ccataacatg       60

acca                                                                    64


<210> 520
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 520
gatttagact accccaaaaa cgaaggggac taaaaccgaa ctgcacctca tggtcatgtt       60

atgg                                                                    64


<210> 521
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 521
gatttagact accccaaaaa cgaaggggac taaaacccat aacatgacca tgaggtgcag       60

ttcg                                                                    64


<210> 522
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 522
gatttagact accccaaaaa cgaaggggac taaaacgcac cccgcattac gtttggtgga       60

ccct                                                                    64


<210> 523
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 523
gatttagact accccaaaaa cgaaggggac taaaacaggg tccaccaaac gtaatgcggg       60

gtgc                                                                    64


<210> 524
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 524
gatttagact accccaaaaa cgaaggggac taaaactgca caatttgccc ccagcgcttc       60

agcg                                                                    64


<210> 525
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 525
gatttagact accccaaaaa cgaaggggac taaaaccgct gaagcgctgg gggcaaattg       60

tgca                                                                    64


<210> 526
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 526
gatttagact accccaaaaa cgaaggggac taaaacatca cattggcacc cgcaatcctg       60

ctaa                                                                    64


<210> 527
<211> 64
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 527
gatttagact accccaaaaa cgaaggggac taaaacttag caggattgcg ggtgccaatg       60

tgat                                                                    64


<210> 528
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 528
gaaattaata cgactcacta tagggtgatt agttcctggt ccccaaa                     47


<210> 529
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 529
gaaattaata cgactcacta tagggacacc atgaggtgct gact                        44


<210> 530
<211> 1263
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 530
Met Glu Asp Tyr Ser Gly Phe Val Asn Ile Tyr Ser Ile Gln Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Glu His Ile Glu 
            20                  25                  30          


Lys Lys Gly Phe Leu Lys Lys Asp Lys Ile Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Ala Val Lys Lys Ile Ile Asp Lys Tyr His Arg Ala Tyr Ile Glu Glu 
    50                  55                  60                  


Val Phe Asp Ser Val Leu His Gln Lys Lys Lys Lys Asp Lys Thr Arg 
65                  70                  75                  80  


Phe Ser Thr Gln Phe Ile Lys Glu Ile Lys Glu Phe Ser Glu Leu Tyr 
                85                  90                  95      


Tyr Lys Thr Glu Lys Asn Ile Pro Asp Lys Glu Arg Leu Glu Ala Leu 
            100                 105                 110         


Ser Glu Lys Leu Arg Lys Met Leu Val Gly Ala Phe Lys Gly Glu Phe 
        115                 120                 125             


Ser Glu Glu Val Ala Glu Lys Tyr Lys Asn Leu Phe Ser Lys Glu Leu 
    130                 135                 140                 


Ile Arg Asn Glu Ile Glu Lys Phe Cys Glu Thr Asp Glu Glu Arg Lys 
145                 150                 155                 160 


Gln Val Ser Asn Phe Lys Ser Phe Thr Thr Tyr Phe Thr Gly Phe His 
                165                 170                 175     


Ser Asn Arg Gln Asn Ile Tyr Ser Asp Glu Lys Lys Ser Thr Ala Ile 
            180                 185                 190         


Gly Tyr Arg Ile Ile His Gln Asn Leu Pro Lys Phe Leu Asp Asn Leu 
        195                 200                 205             


Lys Ile Ile Glu Ser Ile Gln Arg Arg Phe Lys Asp Phe Pro Trp Ser 
    210                 215                 220                 


Asp Leu Lys Lys Asn Leu Lys Lys Ile Asp Lys Asn Ile Lys Leu Thr 
225                 230                 235                 240 


Glu Tyr Phe Ser Ile Asp Gly Phe Val Asn Val Leu Asn Gln Lys Gly 
                245                 250                 255     


Ile Asp Ala Tyr Asn Thr Ile Leu Gly Gly Lys Ser Glu Glu Ser Gly 
            260                 265                 270         


Glu Lys Ile Gln Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Arg Gln Lys 
        275                 280                 285             


Asn Asn Ile Asp Arg Lys Asn Leu Pro Asn Val Lys Ile Leu Phe Lys 
    290                 295                 300                 


Gln Ile Leu Gly Asp Arg Glu Thr Lys Ser Phe Ile Pro Glu Ala Phe 
305                 310                 315                 320 


Pro Asp Asp Gln Ser Val Leu Asn Ser Ile Thr Glu Phe Ala Lys Tyr 
                325                 330                 335     


Leu Lys Leu Asp Lys Lys Lys Lys Ser Ile Ile Ala Glu Leu Lys Lys 
            340                 345                 350         


Phe Leu Ser Ser Phe Asn Arg Tyr Glu Leu Asp Gly Ile Tyr Leu Ala 
        355                 360                 365             


Asn Asp Asn Ser Leu Ala Ser Ile Ser Thr Phe Leu Phe Asp Asp Trp 
    370                 375                 380                 


Ser Phe Ile Lys Lys Ser Val Ser Phe Lys Tyr Asp Glu Ser Val Gly 
385                 390                 395                 400 


Asp Pro Lys Lys Lys Ile Lys Ser Pro Leu Lys Tyr Glu Lys Glu Lys 
                405                 410                 415     


Glu Lys Trp Leu Lys Gln Lys Tyr Tyr Thr Ile Ser Phe Leu Asn Asp 
            420                 425                 430         


Ala Ile Glu Ser Tyr Ser Lys Ser Gln Asp Glu Lys Arg Val Lys Ile 
        435                 440                 445             


Arg Leu Glu Ala Tyr Phe Ala Glu Phe Lys Ser Lys Asp Asp Ala Lys 
    450                 455                 460                 


Lys Gln Phe Asp Leu Leu Glu Arg Ile Glu Glu Ala Tyr Ala Ile Val 
465                 470                 475                 480 


Glu Pro Leu Leu Gly Ala Glu Tyr Pro Arg Asp Arg Asn Leu Lys Ala 
                485                 490                 495     


Asp Lys Lys Glu Val Gly Lys Ile Lys Asp Phe Leu Asp Ser Ile Lys 
            500                 505                 510         


Ser Leu Gln Phe Phe Leu Lys Pro Leu Leu Ser Ala Glu Ile Phe Asp 
        515                 520                 525             


Glu Lys Asp Leu Gly Phe Tyr Asn Gln Leu Glu Gly Tyr Tyr Glu Glu 
    530                 535                 540                 


Ile Asp Ser Ile Gly His Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr 
545                 550                 555                 560 


Gly Lys Ile Tyr Ser Lys Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser 
                565                 570                 575     


Thr Leu Leu Lys Gly Trp Asp Glu Asn Arg Glu Val Ala Asn Leu Cys 
            580                 585                 590         


Val Ile Phe Arg Glu Asp Gln Lys Tyr Tyr Leu Gly Val Met Asp Lys 
        595                 600                 605             


Glu Asn Asn Thr Ile Leu Ser Asp Ile Pro Lys Val Lys Pro Asn Glu 
    610                 615                 620                 


Leu Phe Tyr Glu Lys Met Val Tyr Lys Leu Ile Pro Thr Pro His Met 
625                 630                 635                 640 


Gln Leu Pro Arg Ile Ile Phe Ser Ser Asp Asn Leu Ser Ile Tyr Asn 
                645                 650                 655     


Pro Ser Lys Ser Ile Leu Lys Ile Arg Glu Ala Lys Ser Phe Lys Glu 
            660                 665                 670         


Gly Lys Asn Phe Lys Leu Lys Asp Cys His Lys Phe Ile Asp Phe Tyr 
        675                 680                 685             


Lys Glu Ser Ile Ser Lys Asn Glu Asp Trp Ser Arg Phe Asp Phe Lys 
    690                 695                 700                 


Phe Ser Lys Thr Ser Ser Tyr Glu Asn Ile Ser Glu Phe Tyr Arg Glu 
705                 710                 715                 720 


Val Glu Arg Gln Gly Tyr Asn Leu Asp Phe Lys Lys Val Ser Lys Phe 
                725                 730                 735     


Tyr Ile Asp Ser Leu Val Glu Asp Gly Lys Leu Tyr Leu Phe Gln Ile 
            740                 745                 750         


Tyr Asn Lys Asp Phe Ser Ile Phe Ser Lys Gly Lys Pro Asn Leu His 
        755                 760                 765             


Thr Ile Tyr Phe Arg Ser Leu Phe Ser Lys Glu Asn Leu Lys Asp Val 
    770                 775                 780                 


Cys Leu Lys Leu Asn Gly Glu Ala Glu Met Phe Phe Arg Lys Lys Ser 
785                 790                 795                 800 


Ile Asn Tyr Asp Glu Lys Lys Lys Arg Glu Gly His His Pro Glu Leu 
                805                 810                 815     


Phe Glu Lys Leu Lys Tyr Pro Ile Leu Lys Asp Lys Arg Tyr Ser Glu 
            820                 825                 830         


Asp Lys Phe Gln Phe His Leu Pro Ile Ser Leu Asn Phe Lys Ser Lys 
        835                 840                 845             


Glu Arg Leu Asn Phe Asn Leu Lys Val Asn Glu Phe Leu Lys Arg Asn 
    850                 855                 860                 


Lys Asp Ile Asn Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu 
865                 870                 875                 880 


Tyr Leu Val Met Ile Asn Gln Lys Gly Glu Ile Leu Lys Gln Thr Leu 
                885                 890                 895     


Leu Asp Ser Met Gln Ser Gly Lys Gly Arg Pro Glu Ile Asn Tyr Lys 
            900                 905                 910         


Glu Lys Leu Gln Glu Lys Glu Ile Glu Arg Asp Lys Ala Arg Lys Ser 
        915                 920                 925             


Trp Gly Thr Val Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Leu Ser 
    930                 935                 940                 


Ile Val Ile His Gln Ile Ser Lys Leu Met Val Glu Asn Asn Ala Ile 
945                 950                 955                 960 


Val Val Leu Glu Asp Leu Asn Ile Gly Phe Lys Arg Gly Arg Gln Lys 
                965                 970                 975     


Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys 
            980                 985                 990         


Leu Asn Phe Leu Val Phe Lys Glu  Asn Lys Pro Thr Glu  Pro Gly Gly 
        995                 1000                 1005             


Val Leu  Lys Ala Tyr Gln Leu  Thr Asp Glu Phe Gln  Ser Phe Glu 
    1010                 1015                 1020             


Lys Leu  Ser Lys Gln Thr Gly  Phe Leu Phe Tyr Val  Pro Ser Trp 
    1025                 1030                 1035             


Asn Thr  Ser Lys Ile Asp Pro  Arg Thr Gly Phe Ile  Asp Phe Leu 
    1040                 1045                 1050             


His Pro  Ala Tyr Glu Asn Ile  Glu Lys Ala Lys Gln  Trp Ile Asn 
    1055                 1060                 1065             


Lys Phe  Asp Ser Ile Arg Phe  Asn Ser Lys Met Asp  Trp Phe Glu 
    1070                 1075                 1080             


Phe Thr  Ala Asp Thr Arg Lys  Phe Ser Glu Asn Leu  Met Leu Gly 
    1085                 1090                 1095             


Lys Asn  Arg Val Trp Val Ile  Cys Thr Thr Asn Val  Glu Arg Tyr 
    1100                 1105                 1110             


Phe Thr  Ser Lys Thr Ala Asn  Ser Ser Ile Gln Tyr  Asn Ser Ile 
    1115                 1120                 1125             


Gln Ile  Thr Glu Lys Leu Lys  Glu Leu Phe Val Asp  Ile Pro Phe 
    1130                 1135                 1140             


Ser Asn  Gly Gln Asp Leu Lys  Pro Glu Ile Leu Arg  Lys Asn Asp 
    1145                 1150                 1155             


Ala Val  Phe Phe Lys Ser Leu  Leu Phe Tyr Ile Lys  Thr Thr Leu 
    1160                 1165                 1170             


Ser Leu  Arg Gln Asn Asn Gly  Lys Lys Gly Glu Glu  Glu Lys Asp 
    1175                 1180                 1185             


Phe Ile  Leu Ser Pro Val Val  Asp Ser Lys Gly Arg  Phe Phe Asn 
    1190                 1195                 1200             


Ser Leu  Glu Ala Ser Asp Asp  Glu Pro Lys Asp Ala  Asp Ala Asn 
    1205                 1210                 1215             


Gly Ala  Tyr His Ile Ala Leu  Lys Gly Leu Met Asn  Leu Leu Val 
    1220                 1225                 1230             


Leu Asn  Glu Thr Lys Glu Glu  Asn Leu Ser Arg Pro  Lys Trp Lys 
    1235                 1240                 1245             


Ile Lys  Asn Lys Asp Trp Leu  Glu Phe Val Trp Glu  Arg Asn Arg 
    1250                 1255                 1260             


<210> 531
<211> 1222
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 531
Met Lys Lys Phe Thr Asn Leu Tyr Ser Leu Ser Lys Thr Leu Arg Phe 
1               5                   10                  15      


Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Gln Lys Ser Gly 
            20                  25                  30          


Ile Leu Glu Gln Asp Asn Ser Arg Ala Glu Lys Tyr Glu Lys Ile Lys 
        35                  40                  45              


Lys Ile Ile Asp Asp Tyr His Lys Phe Phe Ile Glu Lys Ser Phe Thr 
    50                  55                  60                  


Gly Lys Lys Ile Asp Asp Tyr Phe Leu Asn Gln Tyr Phe Glu Leu Phe 
65                  70                  75                  80  


Lys Ile Lys Asp Lys Asp Glu Glu Gln Lys Lys Asp Phe Lys Ser Ile 
                85                  90                  95      


Gln Glu Asn Leu Arg Lys Asn Ile Ile Ser Phe Phe Asp Lys Asn Lys 
            100                 105                 110         


Leu Lys Arg Leu Phe Glu Lys Glu Ile Ile Lys Glu Asp Leu Pro Asn 
        115                 120                 125             


Phe Val Lys Glu Glu Glu Asp Lys Lys Leu Ile Ser Glu Phe Asp Lys 
    130                 135                 140                 


Phe Thr Thr Tyr Phe Val Gly Phe His Glu Asn Arg Lys Ser Met Tyr 
145                 150                 155                 160 


Ser Glu Glu Glu Lys Ser Thr Ser Ile Ala Tyr Arg Thr Ile Asn Glu 
                165                 170                 175     


Asn Leu Pro Lys Phe Ile Asn Asn Ile Phe Val Phe Glu Lys Ile Ser 
            180                 185                 190         


Lys Thr Pro Ile Ser Glu Asn Phe Arg Glu Leu Tyr Lys Asp Leu Glu 
        195                 200                 205             


Glu Tyr Leu Asn Val Asn Asp Ile Gln Asp Ile Phe Lys Leu Asn Tyr 
    210                 215                 220                 


Phe Ser Asn Val Ile Thr Gln Lys Gln Ile Asp Val Tyr Asn Leu Val 
225                 230                 235                 240 


Ile Gly Gly Lys Thr Leu Glu Asn Gly Thr Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Asn Gln Thr Asp Lys Lys Asn Lys 
            260                 265                 270         


Leu Pro Leu Leu Thr Val Leu Phe Lys Gln Ile Leu Cys Asp Arg Asp 
        275                 280                 285             


Thr Ile Ser Phe Leu Pro Glu Gln Phe Glu Asn Asp Ile Asp Val Leu 
    290                 295                 300                 


Asp Asn Ile Lys Asn Thr Tyr Ser Asn Met Glu Lys Ser Ile Lys Asp 
305                 310                 315                 320 


Ile Lys Asp Leu Leu Ser Asn Leu Lys Asp Phe Asp Leu Ser Lys Ile 
                325                 330                 335     


Tyr Ile Thr Asn Asp Ile Ala Leu Thr Asp Ile Ser Gln Gln Val Phe 
            340                 345                 350         


Asn Asn Tyr Ser Ile Ile Ile Asn Ala Ile Lys Glu Asn Ile Lys Lys 
        355                 360                 365             


Glu Asn Pro Lys Lys Lys Thr Glu Asn Glu Glu Lys Tyr Gly Glu Arg 
    370                 375                 380                 


Ile Asp Lys Ile Phe Lys Ser Asn Asn Ser Phe Ser Ile Lys Tyr Ile 
385                 390                 395                 400 


Asn Asp Cys Ile Lys Glu Lys Asn Ile Glu Ile Tyr Phe Met Asp Phe 
                405                 410                 415     


Gly Lys Lys Glu Asn Asn Lys Lys Val Lys Asn Leu Phe Asp Glu Leu 
            420                 425                 430         


Gln Asn Asn Tyr Ser Met Val Lys Asp Leu Leu Glu Tyr Lys Lys Ile 
        435                 440                 445             


Gln Ser Leu Ile Gln Asp Glu Lys Ser Ile Glu Leu Ile Lys Asn Phe 
    450                 455                 460                 


Leu Asp Ser Ile Lys Asn Ile Gln His Phe Leu Lys Pro Leu Tyr Val 
465                 470                 475                 480 


Lys Asp Asn Asp Ile Val Lys Asp Ile Ser Phe Tyr Arg Asp Phe Glu 
                485                 490                 495     


Glu Leu Tyr Leu Asn Ile Asp Lys Ile Thr Pro Leu Tyr Asn Lys Val 
            500                 505                 510         


Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Val Lys Lys Ile Lys Leu 
        515                 520                 525             


Asn Phe Glu Asn Ser Thr Leu Leu Ala Gly Trp Asp Leu Asn Lys Glu 
    530                 535                 540                 


Arg Asp Asn Thr Cys Ala Ile Leu Arg Lys Asp Asp Leu Tyr Tyr Leu 
545                 550                 555                 560 


Ala Ile Met Asp Val Asn Asn Arg Asn Val Phe Asn Glu Lys Gly Ile 
                565                 570                 575     


Asp Gly Ile Gly Tyr Glu Lys Met Glu Tyr Lys Leu Leu Pro Gly Ala 
            580                 585                 590         


Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Ser Arg Ile Lys Asp 
        595                 600                 605             


Phe Asn Pro Ser Glu Gln Ile Ile Arg Asn Tyr Glu Lys Glu Thr His 
    610                 615                 620                 


Lys Lys Gly Ser Asn Phe Ser Leu Lys Asp Cys His Lys Leu Ile Asp 
625                 630                 635                 640 


Phe Phe Lys Ser Ser Ile Asn Lys His Glu Asp Trp Lys Asn Phe Asn 
                645                 650                 655     


Phe Lys Phe Ser Asn Thr Asp Lys Tyr Glu Asp Leu Ser Gly Phe Tyr 
            660                 665                 670         


Arg Glu Val Glu Gln Gln Gly Tyr Lys Ile Thr Phe Arg Asn Ile Ser 
        675                 680                 685             


Lys Glu Tyr Val Asp Lys Leu Val Glu Glu Gly Lys Ile Tyr Leu Phe 
    690                 695                 700                 


Gln Ile Tyr Asn Lys Asp Phe Ser Lys Tyr Ser Lys Gly Thr Pro Asn 
705                 710                 715                 720 


Met His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Asp Asn Leu Lys 
                725                 730                 735     


Asn Val Val Tyr Lys Leu Asn Gly Gln Ala Glu Ile Phe Tyr Arg Lys 
            740                 745                 750         


Gly Ser Ile Glu Lys Glu Asn Ile Val Ile His Lys Ala Asn Asn Ala 
        755                 760                 765             


Ile Glu Asn Lys Asn Met Asp Asn Lys Lys Lys Gln Ser Lys Phe Glu 
    770                 775                 780                 


Tyr Asp Ile Ile Lys Asp Arg Arg Tyr Thr Val Asp Lys Phe Gln Phe 
785                 790                 795                 800 


His Val Pro Ile Thr Leu Asn Phe Lys Ala Ile Gly Asn Glu Arg Ile 
                805                 810                 815     


Asn Glu Gln Val Asn Gln Tyr Ile Lys Asp Asn Asn Ile Lys His Ile 
            820                 825                 830         


Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Phe Leu Ser Leu Ile 
        835                 840                 845             


Asp Leu Lys Gly Asn Ile Ile Lys Gln Phe Ser Leu Asn Glu Ile Val 
    850                 855                 860                 


Asn Glu Tyr Asn Gly Asn Ser Tyr Lys Thr Asn Tyr His Met Leu Leu 
865                 870                 875                 880 


Glu Lys Arg Glu Glu Glu Arg Asp Lys Ala Arg Lys Ser Trp Lys Thr 
                885                 890                 895     


Ile Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Ile Ser Gln Val Ile 
            900                 905                 910         


His Lys Ile Thr Gln Leu Met Ile Glu Tyr Asn Ala Ile Val Val Leu 
        915                 920                 925             


Glu Asp Leu Asn Phe Gly Phe Met Arg Gly Arg Gln Lys Val Glu Lys 
    930                 935                 940                 


Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr 
945                 950                 955                 960 


Leu Val Asp Lys Lys Lys Asp Lys Asn Glu Ala Gly Gly Leu Leu Lys 
                965                 970                 975     


Ala His Gln Leu Thr Asn Lys Phe Glu Ser Phe Gln Lys Met Gly Lys 
            980                 985                 990         


Gln Asn Gly Phe Leu Phe Tyr Ile  Pro Ala Trp Asn Thr  Ser Lys Leu 
        995                 1000                 1005             


Asp Pro  Ile Thr Gly Phe Val  Asn Leu Phe Asp Thr  His Tyr Thr 
    1010                 1015                 1020             


Asn Val  Asp Asn Ala Lys Lys  Phe Phe Glu Asn Phe  Glu Asp Ile 
    1025                 1030                 1035             


Arg Phe  Asn Glu Lys Lys Asn  Tyr Phe Glu Phe Ile  Val Asn Asp 
    1040                 1045                 1050             


Tyr Thr  Lys Phe Asn Thr Lys  Ala Glu Gly Thr Lys  Leu Asn Trp 
    1055                 1060                 1065             


Thr Ile  Cys Ser Asn Glu Asp  Arg Ile Lys Thr Phe  Arg Ser Ser 
    1070                 1075                 1080             


Ser Lys  Asn Asn Gln Trp Val  Ser Glu Thr Val Asn  Leu Thr Asp 
    1085                 1090                 1095             


Ser Leu  Ile Glu Leu Phe Lys  Lys Tyr Asp Ile Asp  Tyr Lys Leu 
    1100                 1105                 1110             


Glu Leu  Lys Glu Gln Ile Ile  Ser Lys Ser Glu Lys  Asn Phe Phe 
    1115                 1120                 1125             


Glu Thr  Leu Leu Tyr Leu Phe  Lys Leu Thr Leu Gln  Met Arg Asn 
    1130                 1135                 1140             


Ser Ile  Thr Gly Thr Glu Thr  Asp Tyr Leu Ile Ser  Pro Val Ala 
    1145                 1150                 1155             


Asp Lys  Thr Gly Asn Phe Phe  Asp Ser Arg Lys Gly  Ile Glu Asn 
    1160                 1165                 1170             


Leu Pro  Asn Asn Ala Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Arg 
    1175                 1180                 1185             


Lys Gly  Leu Trp Val Ile Glu  Gln Ile Lys Lys Ala  Lys Asp Leu 
    1190                 1195                 1200             


Lys Lys  Val Lys Leu Ala Ile  Ser Asn Lys Glu Trp  Leu Gln Phe 
    1205                 1210                 1215             


Val Gln  Gly Lys 
    1220         


<210> 532
<211> 1262
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 532
Met Ala Lys Asn Thr Ile Phe Ser Gln Phe Thr Gly Leu Tyr Pro Val 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Met Gly Lys Thr Leu Glu 
            20                  25                  30          


Lys Ile Lys Glu Thr Gly Val Ile Glu Asn Asp Lys Lys Arg His Asn 
        35                  40                  45              


Asp Tyr Phe Asp Ala Lys Lys Ile Ile Asp Lys Tyr His Lys Tyr Phe 
    50                  55                  60                  


Ile Asp Ala Ala Leu Ser Lys Phe Pro Arg Ile Asp Trp Ser Pro Leu 
65                  70                  75                  80  


Lys Glu Ala Ile Glu Arg Ser Leu Asp Arg Ser Asp Ala Ser Lys Lys 
                85                  90                  95      


Lys Leu Glu Lys Thr Gln Thr Glu Phe Arg Lys Lys Ile Ala Lys Ala 
            100                 105                 110         


Leu Thr Thr His Asp His Tyr Lys Glu Leu Thr Ala Ser Thr Pro Lys 
        115                 120                 125             


Asp Leu Phe Leu Lys Val Phe Pro Asp His Phe Gly Lys Gln Pro Ala 
    130                 135                 140                 


Ile Asp Thr Phe Asp Gly Phe Ser Ser Tyr Phe Thr Gly Phe Gln Glu 
145                 150                 155                 160 


Asn Arg Gln Asn Ile Tyr Ser Asp Glu Ala Ile Ser Thr Ala Ile Pro 
                165                 170                 175     


Tyr Arg Leu Val His Asp Asn Phe Pro Lys Phe Leu Ser Asn Ile Glu 
            180                 185                 190         


Val Tyr Lys Thr Leu Lys Asp Asn Ala Pro Ser Val Leu Ser Asp Ala 
        195                 200                 205             


Glu Asn Glu Leu Arg Asp Phe Leu Asn Gly Lys Ser Leu Ala Asn Ile 
    210                 215                 220                 


Phe Glu Leu Asn Ala Tyr Asn Glu Val Leu Thr Gln Ser Gly Ile Asp 
225                 230                 235                 240 


Phe Phe Asn Gln Val Ile Gly Gly Ile Ser Asp Glu Gly Gly Glu Lys 
                245                 250                 255     


Lys Thr Arg Gly Ile Asn Glu Phe Ser Asn Leu Tyr Arg Gln Gln His 
            260                 265                 270         


Pro Glu Phe Ala Gln Lys Arg Leu Ala Thr Lys Met Ile Pro Leu Tyr 
        275                 280                 285             


Lys Gln Ile Leu Ser Asp Arg Glu Thr Lys Ser Phe Ile Leu Glu Ser 
    290                 295                 300                 


Tyr Ser Asn Asp Ser Gln Val Gln Asn Ser Val Lys Glu Phe Phe Glu 
305                 310                 315                 320 


Ser Gln Ile Leu Asn Trp Asp Ile Ala Gly Arg Arg Val Asn Val Leu 
                325                 330                 335     


Asn Glu Leu Thr Ser Leu Val Lys Arg Ile Ser Glu Phe Asp Leu Gly 
            340                 345                 350         


Asn Ile Tyr Val Asn Gln Glu Glu Leu Ser Asn Ile Ser Leu Lys Leu 
        355                 360                 365             


Phe Asp Asn Trp Asn Ser Ile Asn Gly Leu Leu Phe Lys His Ala Glu 
    370                 375                 380                 


Asn Arg Ile Gly Ser Ala Glu Lys Ser Ala Asn Lys Lys Lys Ile Asp 
385                 390                 395                 400 


Ala Trp Met Lys Asn Lys Glu Phe Ser Ile Ala Thr Leu Asn Leu Ala 
                405                 410                 415     


Ile Ala Glu Ser Asn Ser Glu Glu Ile Ser Arg Val Lys Ile Glu Ser 
            420                 425                 430         


Tyr Trp Asn Asn Phe Glu Ala Lys Val Gln Ser Ile Leu Cys Gly Asp 
        435                 440                 445             


Asn Arg Arg Asn Leu Asp Glu Phe Ile Ser Ala Thr Phe Asn Glu Asn 
    450                 455                 460                 


Asn Ala Leu Arg Glu Asp Ser Lys Ile Ile Glu Lys Leu Lys Ala Phe 
465                 470                 475                 480 


Leu Asp Ala Leu Ile Glu Ile Met His Ser Ile Lys Pro Leu Ile Ser 
                485                 490                 495     


Asp Ala Glu Asn Arg Asp Leu Ser Phe Tyr Asn Glu Leu Ile Pro Leu 
            500                 505                 510         


Tyr Asp Gln Leu Ser Leu Val Val Pro Leu Tyr Asn Lys Ile Arg Asn 
        515                 520                 525             


Tyr Ala Thr Gln Lys Leu Thr Glu Ser Glu Lys Phe Lys Leu Asn Phe 
    530                 535                 540                 


Asp Asn Pro Thr Leu Ala Asp Gly Trp Asp Gln Asn Lys Glu Glu Ala 
545                 550                 555                 560 


Asn Thr Ala Ile Leu Leu Leu Lys Asn Gly Leu Tyr Tyr Leu Gly Ile 
                565                 570                 575     


Met Asn Ala Lys Asn Lys Pro Lys Ile Lys Asp Phe Lys Thr Ser Glu 
            580                 585                 590         


Ser Glu Asp Cys Tyr Asp Lys Met Val Tyr Lys Leu Leu Pro Gly Pro 
        595                 600                 605             


Asn Lys Met Leu Pro Lys Val Phe Phe Ser Glu Lys Gly Leu Ala Thr 
    610                 615                 620                 


Phe Lys Pro Pro Lys Asp Ile Leu Asp Gly Tyr Asn Ala Gly Lys His 
625                 630                 635                 640 


Lys Lys Gly Asp Leu Phe Asp Ile Gly Phe Cys His Gln Leu Ile Asp 
                645                 650                 655     


Phe Phe Lys Glu Ser Ile Ala Lys His Pro Asp Trp Lys Lys Phe Asp 
            660                 665                 670         


Phe Asn Phe Ser Asp Thr Ser Ser Tyr Glu Asp Ile Ser Gly Phe Tyr 
        675                 680                 685             


Lys Glu Val Thr Asp Gln Gly Tyr Lys Ile Thr Phe Ser Lys Ile Pro 
    690                 695                 700                 


Thr Ser Gln Ile Asp Glu Trp Val Lys Glu Gly Lys Leu Phe Leu Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ala Pro Gly Ala Lys Gly Ser Pro Asn 
                725                 730                 735     


Leu His Thr Leu Tyr Trp Lys Ser Val Phe Ser Pro Glu Asn Leu Lys 
            740                 745                 750         


Asp Val Val Val Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr Arg Pro 
        755                 760                 765             


Ser Ser Val Lys Lys Pro Tyr Ser His Lys Val Gly Glu Lys Leu Val 
    770                 775                 780                 


Asn Arg Ile Gly Lys Asp Gly Leu Pro Leu Pro Glu Ser Val Phe Gly 
785                 790                 795                 800 


Glu Leu Phe Arg Tyr Phe Asn Gly Lys Leu Glu Gly Glu Leu Ser Asp 
                805                 810                 815     


Glu Ala Lys Arg Tyr Leu Asp Val Ala Val Val Lys Asp Val Lys His 
            820                 825                 830         


Glu Ile Val Lys Asp Arg Arg Tyr Thr Gln Asp Lys Phe Glu Phe His 
        835                 840                 845             


Val Pro Leu Thr Leu Asn Phe Lys Ala Asp Ser Lys Asn Glu Tyr Met 
    850                 855                 860                 


Asn Glu Arg Val Arg His Phe Leu Lys Asp Asn Pro Asp Val Asn Ile 
865                 870                 875                 880 


Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Met Thr Leu Ile 
                885                 890                 895     


Asn Gln Lys Gly Glu Ile Leu Lys Gln Lys Ser Phe Asn Val Val Glu 
            900                 905                 910         


Ser Val Asn Tyr Gln Ala Lys Leu Val Gln Arg Glu Lys Glu Arg Asp 
        915                 920                 925             


Ala Ala Arg Arg Ser Trp Ser Ser Val Gly Lys Ile Lys Asp Leu Lys 
    930                 935                 940                 


Glu Gly Phe Leu Ser Gln Val Ile His Glu Ile Thr Thr Thr Met Ile 
945                 950                 955                 960 


Glu Asn Asn Ala Ile Val Val Leu Glu Asp Leu Asn Phe Gly Phe Lys 
                965                 970                 975     


Arg Gly Arg Phe Cys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys 
            980                 985                 990         


Met Leu Ile Asp Lys Leu Asn Tyr  Leu Val Phe Lys Asn  Lys Pro Glu 
        995                 1000                 1005             


Gly Asp  Val Gly Gly Val Leu  Lys Gly Tyr Gln Leu  Ala Glu Lys 
    1010                 1015                 1020             


Phe Asp  Ser Phe Gln Lys Leu  Gly Lys Gln Ser Gly  Phe Leu Phe 
    1025                 1030                 1035             


Tyr Ile  Pro Ala Ala Tyr Thr  Ser Lys Ile Asp Pro  Thr Thr Gly 
    1040                 1045                 1050             


Phe Ala  Asn Leu Phe Asn Met  Thr Glu Leu Thr Ser  Ala Glu Lys 
    1055                 1060                 1065             


Lys Lys  Glu Phe Leu Ser His  Phe Glu Asp Ile Thr  Tyr Asp Gly 
    1070                 1075                 1080             


Lys Asn  Asp Arg Phe Leu Phe  Ser Phe Asp Tyr Lys  Asn Phe Lys 
    1085                 1090                 1095             


Cys Phe  Gln Thr Asp Tyr Ile  Lys Lys Trp Thr Val  Tyr Ser Gln 
    1100                 1105                 1110             


Gly Lys  Arg Ile Val Tyr Asp  Lys Glu Ser Lys Ser  Ala Lys Glu 
    1115                 1120                 1125             


Ile Ser  Pro Val Glu Ile Ile  Lys Ala Ala Leu Ala  Lys Gln Asn 
    1130                 1135                 1140             


Ile Ala  Leu Thr Asp Gln Leu  Asp Val Leu Ser Ala  Ile Asn Ser 
    1145                 1150                 1155             


Val Glu  Ala Ser Pro Lys Ser  Ala Ser Phe Phe Gly  Asp Ile Cys 
    1160                 1165                 1170             


Tyr Ala  Phe Glu Lys Thr Leu  Gln Met Arg Asn Ser  Ile Pro Asn 
    1175                 1180                 1185             


Thr Asp  Glu Asp Tyr Leu Ala  Ser Pro Val Met Asn  Lys Arg Gly 
    1190                 1195                 1200             


Glu Phe  Tyr Asp Ser Arg Ser  Cys Asp Asp Ala Leu  Pro Gln Asn 
    1205                 1210                 1215             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Tyr 
    1220                 1225                 1230             


Leu Ile  Lys Asn Val Phe Asp  Ala Gly Gly Lys Glu  Leu Lys Ile 
    1235                 1240                 1245             


Ser His  Glu Asp Trp Phe Lys  Phe Ala Gln Ser Arg  Asn Cys 
    1250                 1255                 1260         


<210> 533
<211> 1253
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 533
Met Ser Lys Gly Lys Ile Trp Glu Asn Phe Ile Asn Gln Tyr Ser Val 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Glu 
            20                  25                  30          


Asn Ile Asn Ala Lys Gly Leu Ile Glu Glu Asp Glu Gln Arg Ala Glu 
        35                  40                  45              


Asp Tyr Lys Lys Ala Lys Lys Ile Ile Asp Glu Tyr His Lys Tyr Phe 
    50                  55                  60                  


Ile Glu Gly Ala Leu Gly Ser Cys Ser Leu Asp Leu Asn Ile Leu Asn 
65                  70                  75                  80  


Glu Phe Leu Gln Leu Tyr Asn Lys Ala Gln Lys Thr Asp Ala Asp Lys 
                85                  90                  95      


Lys Glu Tyr Glu Lys Ile Gln Thr Thr Leu Arg Lys Asn Ile Ala Glu 
            100                 105                 110         


Ser Phe Gly Lys Asn Ala Asp Lys Lys Thr Lys Glu Gln Tyr Glu Asn 
        115                 120                 125             


Leu Phe Lys Lys Glu Leu Leu Arg Asn Asp Leu Pro Asp Trp Val Glu 
    130                 135                 140                 


Asp Glu Glu Asp Ala Lys Ile Ile Glu Arg Phe Lys Thr Phe Thr Thr 
145                 150                 155                 160 


Tyr Phe Thr Gly Phe His Glu Asn Arg Lys Asn Ile Tyr Asp Asn Glu 
                165                 170                 175     


Glu Lys Ser Thr Ala Ile Gly Tyr Arg Ile Val His Glu Asn Leu Pro 
            180                 185                 190         


Lys Phe Ile Asp Asn Met Asn Ala Phe Glu Lys Ile Ser Lys Ala Leu 
        195                 200                 205             


Asp Leu Ser Glu Ile Asp Arg Asp Phe Gln Ser Glu Leu Gly Glu Ile 
    210                 215                 220                 


Lys Ala Glu Glu Phe Phe Thr Ile Glu Phe Phe Asn Gln Cys Leu Asn 
225                 230                 235                 240 


Gln Phe Gly Ile Asp Arg Tyr Asn Thr Leu Leu Gly Gly Ile Ser Glu 
                245                 250                 255     


Gly Glu Asn Ile Lys Lys Lys Gln Gly Leu Asn Glu Arg Ile Asn Leu 
            260                 265                 270         


Tyr Asn Gln Gln Leu Lys Gly Glu Arg Lys Lys Glu Arg Leu Pro Lys 
        275                 280                 285             


Leu Lys Val Leu Tyr Lys Gln Ile Leu Ser Asp Ser Ser Ser His Ser 
    290                 295                 300                 


Phe Ser Ile Asp Glu Phe Glu Asn Asp Asn Glu Leu Leu Glu Ser Leu 
305                 310                 315                 320 


Glu Ile Phe Tyr Lys Asn Glu Leu Ile Gly Phe Asn His Ser Gly Val 
                325                 330                 335     


Asp Ser Asn Ile Phe Asp Leu Val Lys Asp Leu Leu Leu Lys Ile Asp 
            340                 345                 350         


Glu Ser Glu Gln Ser Ser Ile Tyr Leu Lys Asn Asp Lys Gly Leu Thr 
        355                 360                 365             


Glu Ile Ser Gln Arg Ile Phe Gly Asp Trp Asn Ile Ile Lys Ser Ala 
    370                 375                 380                 


Leu Glu Glu Tyr Tyr Asp Glu His Tyr Pro Pro Lys Lys Asp Thr Phe 
385                 390                 395                 400 


Asn Lys Lys Glu Leu Asp Glu Arg Ser Arg Trp Leu Lys Glu Asn His 
                405                 410                 415     


Ser Ile Gly Val Ile Glu Lys Ala Leu Ala Asn Tyr Glu Asn Glu Ile 
            420                 425                 430         


Val Arg Glu His Leu Lys Gln Asn Ser Ala Pro Ile Val Ser Tyr Phe 
        435                 440                 445             


Lys Ser Leu Glu Val Asp Gly Glu Asn Leu Ile Asp Lys Ile Tyr Ser 
    450                 455                 460                 


Ala Tyr Gly Asn Ile Ser Asp Leu Leu Asn Ser Ser Tyr Pro Asp Glu 
465                 470                 475                 480 


Lys Lys Leu Val Ser Asp Arg Thr Ser Lys Asp Lys Ile Lys Val Phe 
                485                 490                 495     


Leu Asp Ser Leu Met Ser Leu Leu His Phe Leu Lys Pro Leu Asp Val 
            500                 505                 510         


Lys Asp Leu Gly Asn Lys Asp Ser Ala Phe Tyr Gly Asp Tyr Asp Phe 
        515                 520                 525             


Ile Val Glu Gln Leu Ser Lys Leu Val Arg Leu Tyr Asn Lys Thr Arg 
    530                 535                 540                 


Asn Tyr Leu Thr Arg Lys Pro Tyr Ser Ile Glu Lys Ile Lys Leu Asn 
545                 550                 555                 560 


Phe Glu Asn Ser Thr Leu Leu Ala Gly Trp Asp Val Asn Lys Glu Arg 
                565                 570                 575     


Asp Asn Asn Cys Val Ile Phe Lys Arg Gln Asp Gly Asp Arg Glu Leu 
            580                 585                 590         


Phe Tyr Leu Gly Ile Met Asp Lys Ser His Asn Lys Ile Phe Thr Lys 
        595                 600                 605             


Ile Glu Glu Ala Lys Ser Asp Asp Val Tyr Gln Lys Met Asn Tyr Lys 
    610                 615                 620                 


Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys 
625                 630                 635                 640 


Lys Ser Ile Asp Phe Tyr Ala Pro Gly Glu Glu Leu Leu Lys Asn Tyr 
                645                 650                 655     


Lys Asn Gly Thr His Lys Lys Gly Glu Asn Phe Asn Leu Gln His Cys 
            660                 665                 670         


His Glu Leu Ile Asp Phe Phe Lys Arg Ser Ile Asn Lys His Glu Asp 
        675                 680                 685             


Trp Ser Gln Phe Asn Phe Lys Phe Ser Asp Thr Ser Glu Tyr Glu Asp 
    690                 695                 700                 


Thr Ser Phe Phe Phe Lys Glu Val Ser Gln Gln Gly Tyr Ser Ile Thr 
705                 710                 715                 720 


Phe Lys Asn Ile Asp Arg Glu Thr Ile Glu Lys Phe Val Asp Glu Gly 
                725                 730                 735     


Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Lys Ser 
            740                 745                 750         


Lys Gly Arg Pro Asn Leu His Thr Leu Tyr Trp Lys Met Leu Phe Asp 
        755                 760                 765             


Glu Arg Asn Leu Ala Asn Thr Val Tyr Gln Leu Asn Gly Glu Ala Glu 
    770                 775                 780                 


Val Phe Tyr Arg Lys Lys Ser Ile Ser Glu Lys Asp Arg Val Val His 
785                 790                 795                 800 


Arg Ala Asp Glu Pro Ile Gly Leu Lys Asn Ser Glu Asn Ser Ala Gln 
                805                 810                 815     


Lys Ser Leu Phe Pro Tyr Asp Ile Val Lys Asp Arg Arg Phe Thr Val 
            820                 825                 830         


Asp Lys Phe Gln Phe His Val Pro Ile Thr Leu Asn Phe Lys Ser Glu 
        835                 840                 845             


Gly Asn Glu Arg Leu Asn Ile Ser Val Asn Lys Phe Leu Lys Asp Asn 
    850                 855                 860                 


Pro Asp Val Asn Ile Ile Gly Leu Asp Arg Gly Glu Arg His Leu Ile 
865                 870                 875                 880 


Tyr Leu Thr Leu Ile Asn Gln Lys Gly Glu Ile Leu His Gln Glu Ser 
                885                 890                 895     


Leu Asn Glu Val Met Gly Val Asn Tyr Gln Gln Lys Leu His Arg Val 
            900                 905                 910         


Glu Lys Asp Arg Thr Glu Glu Arg Arg Asn Trp Asp Arg Ile Glu Asn 
        915                 920                 925             


Ile Lys Glu Leu Lys Ser Gly Tyr Leu Ser Gln Val Val His Lys Ile 
    930                 935                 940                 


Ser Gln Leu Met Val Glu Tyr Asn Ala Ile Val Val Met Glu Asp Leu 
945                 950                 955                 960 


Asn Phe Gly Phe Lys Arg Gly Arg Ile Lys Val Glu Lys Gln Val Tyr 
                965                 970                 975     


Gln Lys Phe Glu Lys Thr Leu Ile Asp Lys Leu Asn Tyr Leu Val Phe 
            980                 985                 990         


Lys Asp Arg Glu Pro Glu Glu Pro  Ala Gly Val Leu Asn  Ala Leu Gln 
        995                 1000                 1005             


Leu Thr  Asn Lys Phe Glu Ser  Phe Lys Lys Leu Gly  Lys Gln Cys 
    1010                 1015                 1020             


Gly Phe  Leu Phe Tyr Val Thr  Ser Asp Tyr Thr Ser  Lys Ile Asp 
    1025                 1030                 1035             


Pro Ala  Thr Gly Phe Val Asn  Leu Leu Tyr Pro Lys  Tyr Glu Ser 
    1040                 1045                 1050             


Val Glu  Lys Ser Gln Asn Phe  Phe Arg Lys Phe Asp  Asn Ile Cys 
    1055                 1060                 1065             


Phe Asn  Ser Gly Ala Gly Tyr  Phe Glu Phe Asp Phe  Asp Tyr Ser 
    1070                 1075                 1080             


Asn Phe  Thr Asp Arg Ala Asp  Gly Thr Arg Thr Arg  Trp Lys Val 
    1085                 1090                 1095             


Cys Thr  Val Gly Asn Glu Arg  Phe Gly Tyr Asn Pro  Lys Thr Lys 
    1100                 1105                 1110             


Ala Ser  Glu Thr Val Asn Val  Thr Glu Ser Leu Lys  Glu Leu Leu 
    1115                 1120                 1125             


Leu Gln  His Glu Ile Ala Phe  Glu Asn Gly Glu Ser  Leu Val Glu 
    1130                 1135                 1140             


Ser Ile  Ser Lys Asn Thr Thr  Lys Tyr Phe His Lys  Ser Leu Leu 
    1145                 1150                 1155             


Asn Phe  Leu Arg Leu Thr Leu  Thr Leu Arg His Ser  Lys Thr Gly 
    1160                 1165                 1170             


Thr Asp  Ile Asp Tyr Ile Leu  Ser Pro Val Ala Asn  Glu Glu Gly 
    1175                 1180                 1185             


Val Phe  Phe Asp Ser Arg Asn  Ala Ser Asp Lys Met  Pro Lys Asp 
    1190                 1195                 1200             


Ala Asp  Ala Asn Gly Ala Tyr  Asn Val Ala Leu Lys  Gly Leu Met 
    1205                 1210                 1215             


Val Leu  Glu Arg Ile Asn Ala  Ala Glu Asp Leu Ser  Gln Phe Lys 
    1220                 1225                 1230             


Phe Lys  Asp Met Ser Ile Lys  Asn Lys Asp Trp Leu  Lys Phe Val 
    1235                 1240                 1245             


Gln Asp  Arg Gln Gly 
    1250             


<210> 534
<211> 1271
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 534
Met Lys Asn Leu Ala Asn Phe Thr Asn Leu Tyr Ser Leu Gln Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Leu Asp Trp Ile Ile 
            20                  25                  30          


Lys Lys Asp Leu Leu Lys Gln Asp Glu Ile Leu Ala Glu Asp Tyr Lys 
        35                  40                  45              


Ile Val Lys Lys Ile Ile Asp Arg Tyr His Lys Asp Phe Ile Asp Leu 
    50                  55                  60                  


Ala Phe Glu Ser Ala Tyr Leu Gln Lys Lys Ser Ser Asp Ser Phe Thr 
65                  70                  75                  80  


Ala Ile Met Glu Ala Ser Ile Gln Ser Tyr Ser Glu Leu Tyr Phe Ile 
                85                  90                  95      


Lys Glu Lys Ser Asp Arg Asp Lys Lys Ala Met Glu Glu Ile Ser Gly 
            100                 105                 110         


Ile Met Arg Lys Glu Ile Val Glu Cys Phe Thr Gly Lys Tyr Ser Glu 
        115                 120                 125             


Val Val Lys Lys Lys Phe Gly Asn Leu Phe Lys Lys Glu Leu Ile Lys 
    130                 135                 140                 


Glu Asp Leu Leu Asn Phe Cys Glu Pro Asp Glu Leu Pro Ile Ile Gln 
145                 150                 155                 160 


Lys Phe Ala Asp Phe Thr Thr Tyr Phe Thr Gly Phe His Glu Asn Arg 
                165                 170                 175     


Glu Asn Met Tyr Ser Asn Glu Glu Lys Ala Thr Ala Ile Ala Asn Arg 
            180                 185                 190         


Leu Ile Arg Glu Asn Leu Pro Arg Tyr Leu Asp Asn Leu Arg Ile Ile 
        195                 200                 205             


Arg Ser Ile Gln Gly Arg Tyr Lys Asp Phe Gly Trp Lys Asp Leu Glu 
    210                 215                 220                 


Ser Asn Leu Lys Arg Ile Asp Lys Asn Leu Gln Tyr Ser Asp Phe Leu 
225                 230                 235                 240 


Thr Glu Asn Gly Phe Val Tyr Thr Phe Ser Gln Lys Gly Ile Asp Arg 
                245                 250                 255     


Tyr Asn Leu Ile Leu Gly Gly Gln Ser Val Glu Ser Gly Glu Lys Ile 
            260                 265                 270         


Gln Gly Leu Asn Glu Leu Ile Asn Leu Tyr Arg Gln Lys Asn Gln Leu 
        275                 280                 285             


Asp Arg Arg Gln Leu Pro Asn Leu Lys Glu Leu Tyr Lys Gln Ile Leu 
    290                 295                 300                 


Ser Asp Arg Thr Arg His Ser Phe Val Pro Glu Lys Phe Ser Ser Asp 
305                 310                 315                 320 


Lys Ala Leu Leu Arg Ser Leu Leu Asp Phe His Lys Glu Val Ile Gln 
                325                 330                 335     


Asn Lys Asn Leu Phe Glu Glu Lys Gln Val Ser Leu Leu Gln Ala Ile 
            340                 345                 350         


Arg Glu Thr Leu Thr Asp Leu Lys Ser Phe Asp Leu Asp Arg Ile Tyr 
        355                 360                 365             


Leu Thr Asn Asp Thr Ser Leu Thr Gln Ile Ser Asn Phe Val Phe Gly 
    370                 375                 380                 


Asp Trp Ser Lys Val Lys Thr Ile Leu Ala Ile Tyr Phe Asp Glu Asn 
385                 390                 395                 400 


Ile Ala Asn Pro Lys Asp Arg Gln Arg Gln Ser Asn Ser Tyr Leu Lys 
                405                 410                 415     


Ala Lys Glu Asn Trp Leu Lys Lys Asn Tyr Tyr Ser Ile His Glu Leu 
            420                 425                 430         


Asn Glu Ala Ile Ser Val Tyr Gly Lys His Ser Asp Glu Glu Leu Pro 
        435                 440                 445             


Asn Thr Lys Ile Glu Asp Tyr Phe Ser Gly Leu Gln Thr Lys Asp Glu 
    450                 455                 460                 


Thr Lys Lys Pro Ile Asp Val Leu Asp Ala Ile Val Ser Lys Tyr Ala 
465                 470                 475                 480 


Asp Leu Glu Ser Leu Leu Thr Lys Glu Tyr Pro Glu Asp Lys Asn Leu 
                485                 490                 495     


Lys Ser Asp Lys Gly Ser Ile Glu Lys Ile Lys Asn Tyr Leu Asp Ser 
            500                 505                 510         


Ile Lys Leu Leu Gln Asn Phe Leu Lys Pro Leu Lys Pro Lys Lys Val 
        515                 520                 525             


Gln Asp Glu Lys Asp Leu Gly Phe Tyr Asn Asp Leu Glu Leu Tyr Leu 
    530                 535                 540                 


Glu Ser Leu Glu Ser Ala Asn Ser Leu Tyr Asn Lys Val Arg Asn Tyr 
545                 550                 555                 560 


Leu Thr Gly Lys Glu Tyr Ser Asp Glu Lys Ile Lys Leu Asn Phe Lys 
                565                 570                 575     


Asn Ser Thr Leu Leu Asp Gly Trp Asp Glu Asn Lys Glu Thr Ser Asn 
            580                 585                 590         


Leu Ser Val Ile Phe Arg Asp Thr Asn Asn Tyr Tyr Leu Gly Ile Leu 
        595                 600                 605             


Asp Lys Gln Asn Asn Arg Ile Phe Glu Ser Ile Pro Glu Ile Gln Ser 
    610                 615                 620                 


Gly Glu Glu Thr Ile Gln Lys Met Val Tyr Lys Leu Leu Pro Gly Ala 
625                 630                 635                 640 


Asn Asn Met Leu Pro Lys Val Phe Phe Ser Glu Lys Gly Leu Leu Lys 
                645                 650                 655     


Phe Asn Pro Ser Asp Glu Ile Thr Ser Leu Tyr Ser Glu Gly Arg Phe 
            660                 665                 670         


Lys Lys Gly Asp Lys Phe Ser Ile Asn Ser Leu His Thr Leu Ile Asp 
        675                 680                 685             


Phe Tyr Lys Lys Ser Leu Ala Val His Glu Asp Trp Ser Val Phe Asn 
    690                 695                 700                 


Phe Lys Phe Asp Glu Thr Ser His Tyr Glu Asp Ile Ser Gln Phe Tyr 
705                 710                 715                 720 


Arg Gln Val Glu Ser Gln Gly Tyr Lys Ile Thr Phe Lys Pro Ile Ser 
                725                 730                 735     


Lys Lys Tyr Ile Asp Thr Leu Val Glu Asp Gly Lys Leu Tyr Leu Phe 
            740                 745                 750         


Gln Ile Tyr Asn Lys Asp Phe Ser Gln Asn Lys Lys Gly Gly Gly Lys 
        755                 760                 765             


Pro Asn Leu His Thr Ile Tyr Phe Lys Ser Leu Phe Glu Lys Glu Asn 
    770                 775                 780                 


Leu Lys Asp Val Ile Val Lys Leu Asn Gly Gln Ala Glu Val Phe Phe 
785                 790                 795                 800 


Arg Lys Lys Ser Ile His Tyr Asp Glu Asn Ile Thr Arg Tyr Gly His 
                805                 810                 815     


His Ser Glu Leu Leu Lys Gly Arg Phe Ser Tyr Pro Ile Leu Lys Asp 
            820                 825                 830         


Lys Arg Phe Thr Glu Asp Lys Phe Gln Phe His Phe Pro Ile Thr Leu 
        835                 840                 845             


Asn Phe Lys Ser Gly Glu Ile Lys Gln Phe Asn Ala Arg Val Asn Ser 
    850                 855                 860                 


Tyr Leu Lys His Asn Lys Asp Val Lys Ile Ile Gly Ile Asp Arg Gly 
865                 870                 875                 880 


Glu Arg His Leu Leu Tyr Leu Ser Leu Ile Asp Gln Asp Gly Lys Ile 
                885                 890                 895     


Leu Arg Gln Glu Ser Leu Asn Leu Ile Lys Asn Asp Gln Asn Phe Lys 
            900                 905                 910         


Ala Ile Asn Tyr Gln Glu Lys Leu His Lys Lys Glu Ile Glu Arg Asp 
        915                 920                 925             


Gln Ala Arg Lys Ser Trp Gly Ser Ile Glu Asn Ile Lys Glu Leu Lys 
    930                 935                 940                 


Glu Gly Tyr Leu Ser Gln Val Val His Thr Ile Ser Lys Leu Met Val 
945                 950                 955                 960 


Glu His Asn Ala Ile Val Val Leu Glu Asp Leu Asn Phe Gly Phe Lys 
                965                 970                 975     


Arg Gly Arg Gln Lys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys 
            980                 985                 990         


Met Leu Ile Glu Lys Leu Asn Phe  Leu Val Phe Lys Asp  Lys Glu Met 
        995                 1000                 1005             


Asp Glu  Pro Gly Gly Ile Leu  Lys Ala Tyr Gln Leu  Thr Asp Asn 
    1010                 1015                 1020             


Phe Val  Ser Phe Glu Lys Met  Gly Lys Gln Thr Gly  Phe Val Phe 
    1025                 1030                 1035             


Tyr Val  Pro Ala Trp Asn Thr  Ser Lys Ile Asp Pro  Lys Thr Gly 
    1040                 1045                 1050             


Phe Val  Asn Phe Leu His Leu  Asn Tyr Glu Asn Val  Asn Gln Ala 
    1055                 1060                 1065             


Lys Glu  Leu Ile Gly Lys Phe  Asp Gln Ile Arg Tyr  Asn Gln Asp 
    1070                 1075                 1080             


Arg Asp  Trp Phe Glu Phe Gln  Val Thr Thr Asp Gln  Phe Phe Thr 
    1085                 1090                 1095             


Lys Glu  Asn Ala Pro Asp Thr  Arg Thr Trp Ile Ile  Cys Ser Thr 
    1100                 1105                 1110             


Pro Thr  Lys Arg Phe Tyr Ser  Lys Arg Thr Val Asn  Gly Ser Val 
    1115                 1120                 1125             


Ser Thr  Ile Glu Ile Asp Val  Asn Gln Lys Leu Lys  Glu Leu Phe 
    1130                 1135                 1140             


Asn Asp  Cys Asn Tyr Gln Asp  Gly Glu Asp Leu Val  Asp Arg Ile 
    1145                 1150                 1155             


Leu Glu  Lys Asp Ser Lys Asp  Phe Phe Ser Lys Leu  Ile Ala Tyr 
    1160                 1165                 1170             


Leu Arg  Ile Leu Thr Ser Leu  Arg Gln Asn Asn Gly  Glu Gln Gly 
    1175                 1180                 1185             


Phe Glu  Glu Arg Asp Phe Ile  Leu Ser Pro Val Val  Gly Ser Asp 
    1190                 1195                 1200             


Gly Lys  Phe Phe Asn Ser Leu  Asp Ala Ser Ser Gln  Glu Pro Lys 
    1205                 1210                 1215             


Asp Ala  Asp Ala Asn Gly Ala  Tyr His Ile Ala Leu  Lys Gly Leu 
    1220                 1225                 1230             


Met Asn  Leu His Val Ile Asn  Glu Thr Asp Asp Glu  Ser Leu Gly 
    1235                 1240                 1245             


Lys Pro  Ser Trp Lys Ile Ser  Asn Lys Asp Trp Leu  Asn Phe Val 
    1250                 1255                 1260             


Trp Gln  Arg Pro Ser Leu Lys  Ala 
    1265                 1270     


<210> 535
<211> 816
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 535
Met Asn Leu Ile Glu Asn Glu Thr Lys Ser Glu Glu Ile Lys Ser Lys 
1               5                   10                  15      


Leu Asp Ser Ile Met Glu Ile Met His Trp Thr Lys Met Phe Ile Ile 
            20                  25                  30          


Glu Glu Glu Ile Glu Lys Asp Val Asn Phe Tyr Asn Glu Ile Glu Glu 
        35                  40                  45              


Ile Tyr Asp Glu Leu Gln Pro Leu Val Thr Ile Tyr Asn Arg Ile Arg 
    50                  55                  60                  


Asn Tyr Val Thr Gln Lys Pro Tyr Ser Glu Glu Lys Ile Lys Leu Asn 
65                  70                  75                  80  


Phe Gly Ile Pro Thr Leu Ala Asn Gly Trp Ser Lys Thr Lys Glu Tyr 
                85                  90                  95      


Asp Asn Asn Ala Ile Ile Met Ile Arg Asp Gly Lys Tyr Tyr Leu Gly 
            100                 105                 110         


Ile Phe Asn Ala Lys Asn Lys Pro Asp Lys Lys Ile Met Glu Gly His 
        115                 120                 125             


Gln Ser Glu Glu Asn Gly Asp Tyr Lys Lys Met Ile Tyr Arg Leu Leu 
    130                 135                 140                 


Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Met Ser Lys Thr Gly 
145                 150                 155                 160 


Ile Ala Glu Tyr Lys Pro Ser Gln Tyr Ile Leu Glu Cys Tyr Glu Gln 
                165                 170                 175     


Asn Lys His Ile Lys Ser Asp Lys Asn Phe Asp Ile Lys Phe Cys Arg 
            180                 185                 190         


Asp Leu Ile Asp Phe Phe Lys Thr Ser Ile Asn Arg His Pro Glu Trp 
        195                 200                 205             


Ser Lys Phe Asn Phe Lys Phe Ser Glu Thr Ser Glu Tyr Glu Asp Ile 
    210                 215                 220                 


Ser Thr Phe Tyr Arg Glu Val Glu Lys Gln Gly Tyr Lys Ile Glu Trp 
225                 230                 235                 240 


Thr Tyr Ile Ser Glu Lys Glu Ile Lys Glu Leu Asp Glu Asn Gly Gln 
                245                 250                 255     


Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Lys Ser Lys 
            260                 265                 270         


Gly Lys Glu Asn Leu His Thr Met Tyr Leu Lys Asn Leu Phe Ser Glu 
        275                 280                 285             


Glu Asn Leu Lys Asn Ile Val Leu Lys Leu Asn Gly Glu Ala Glu Val 
    290                 295                 300                 


Phe Phe Arg Lys Ser Ser Ile Lys Lys Pro Ile Ile His Lys Lys Gly 
305                 310                 315                 320 


Ser Val Leu Val Asn Lys Thr Tyr Asn Glu Asn Gly Glu Arg Lys Ser 
                325                 330                 335     


Ile Pro Glu Glu Gln Tyr Thr Glu Ile Tyr Lys Tyr Leu Asn Ser Ile 
            340                 345                 350         


Gly Thr Asn Glu Leu Ser Glu Lys Ser Lys Lys Leu Met Glu Glu Gly 
        355                 360                 365             


Lys Val Glu Tyr Tyr Lys Ala Asn Tyr Asp Ile Val Lys Asp Tyr Arg 
    370                 375                 380                 


Tyr Ser Val Asp Lys Phe Phe Ile His Leu Pro Met Thr Ile Asn Phe 
385                 390                 395                 400 


Lys Ala Ala Gly Phe Ser Pro Ile Asn Asn Ile Ala Leu Lys Ser Ile 
                405                 410                 415     


Ala Leu Lys Glu Asp Met His Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            420                 425                 430         


Asn Leu Ile Tyr Val Ser Val Ile Asp Thr Lys Gly Asn Ile Val Glu 
        435                 440                 445             


Gln Arg Asn Phe Asn Ile Val Asn Gly Ile Asp Tyr Lys Glu Lys Leu 
    450                 455                 460                 


Lys Gln Lys Glu Leu Asp Arg Asp Asn Ala Arg Lys Asn Trp Lys Glu 
465                 470                 475                 480 


Ile Gly Lys Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ser Leu Val Val 
                485                 490                 495     


His Glu Ile Ala Lys Leu Val Val Lys Tyr Asn Ala Ile Ile Thr Met 
            500                 505                 510         


Glu Asp Leu Asn Gln Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Arg 
        515                 520                 525             


Gln Val Tyr Gln Lys Phe Glu Thr Met Leu Ile Asn Lys Leu Asn Tyr 
    530                 535                 540                 


Leu Val Asp Lys Asp Leu Ala Val Asp Gln Glu Gly Gly Leu Leu Arg 
545                 550                 555                 560 


Gly Tyr Gln Leu Thr Tyr Ile Pro Glu Ser Leu Lys Val Leu Gly Arg 
                565                 570                 575     


Gln Cys Gly Tyr Ile Phe Tyr Val Pro Val Ala Tyr Thr Ser Lys Ile 
            580                 585                 590         


Asp Pro Thr Thr Gly Phe Val Ala Ile Phe Asn Tyr Lys Gly Met Thr 
        595                 600                 605             


Asp Lys Asp Phe Val Thr Ser Phe Asp Ser Ile Lys Tyr Asp Asp Glu 
    610                 615                 620                 


Arg Gly Leu Phe Ala Phe Glu Phe Asp Tyr Glu Asn Phe Val Thr His 
625                 630                 635                 640 


Lys Val Glu Met Ala Arg Asn Lys Trp Thr Val Tyr Thr Tyr Gly Glu 
                645                 650                 655     


Arg Ile Lys Arg Lys Phe Lys Asn Gly Leu Trp Asp Thr Ala Glu Lys 
            660                 665                 670         


Val Asp Leu Thr Tyr Gln Met Arg Ser Ile Leu Glu Lys Tyr Glu Ile 
        675                 680                 685             


Glu Tyr Asn Lys Gly Gln Asp Ile Leu Glu Gln Ile Glu Glu Leu Asp 
    690                 695                 700                 


Glu Lys Ala Gln Asn Gly Ile Cys Lys Glu Ile Lys Tyr Leu Val Lys 
705                 710                 715                 720 


Asp Ile Val Gln Met Arg Asn Ser Leu Pro Asp Asn Ala Val Glu Asp 
                725                 730                 735     


Tyr Asp Ala Ile Ile Ser Pro Val Ile Asn Asn Asn Gly Glu Phe Phe 
            740                 745                 750         


Asp Ser Thr Arg Gly Asp Glu Asp Lys Pro Leu Asp Ala Asp Ala Asn 
        755                 760                 765             


Gly Ala Tyr Cys Ile Ala Leu Lys Gly Leu Tyr Glu Val Met Gln Ile 
    770                 775                 780                 


Lys Lys Asn Trp Asn Glu Glu Thr Glu Phe Pro Arg Lys Glu Leu Lys 
785                 790                 795                 800 


Ile Arg His Gln Asp Trp Phe Asp Phe Ile Gln Asn Lys Arg Tyr Leu 
                805                 810                 815     


<210> 536
<211> 869
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 536
Met Glu Asn Arg Tyr Gln Val Leu Gln Gly Leu Thr Ala Ala Gln Lys 
1               5                   10                  15      


Lys Ala Ala Ala Ala Ala Lys Lys Arg Ser Ser Phe Ser Ile Val Glu 
            20                  25                  30          


Leu Asn Ala Ala Thr Arg Ser Arg Val Pro Asp Glu Lys Tyr Val Pro 
        35                  40                  45              


Val Gln Asn Tyr Phe Ser Ala Met Gly Lys Val Cys Ser Gln Gly Glu 
    50                  55                  60                  


Pro Lys Arg Glu Asn Phe Val Thr Arg Ile Cys Ala Ala Tyr Gln Glu 
65                  70                  75                  80  


Leu Glu Glu Tyr Ile Pro Ser Ile Arg Lys Ser Leu Leu Gln Glu Lys 
                85                  90                  95      


Arg Ala Thr Glu Leu Ile Lys Asn Tyr Leu Asp Ala Val Asn Asp Leu 
            100                 105                 110         


Leu Arg Phe Ile Lys Pro Leu Leu Gly Arg Gly Asn Glu Thr Asp Lys 
        115                 120                 125             


Asp Ala Asn Phe Tyr Gly Glu Phe Ser Phe Leu Thr Asp Cys Leu Phe 
    130                 135                 140                 


Ala Ile Val Pro Leu Tyr Asn Glu Val Arg Asn Tyr Leu Thr Gln Lys 
145                 150                 155                 160 


Pro Tyr Ser Thr Glu Lys Phe Lys Leu Asn Phe Arg Gly Ser Thr Leu 
                165                 170                 175     


Leu Asn Gly Trp Asp Lys Asn Lys Glu Arg Asp Asn Leu Gly Val Ile 
            180                 185                 190         


Leu Arg Lys Glu Gly Lys Tyr Phe Leu Ala Ile Met Asn Lys Lys His 
        195                 200                 205             


Asn Thr Leu Phe Thr Glu Gly Lys Leu Gln Gln His Thr Gly Gly Glu 
    210                 215                 220                 


Cys Tyr Gln Lys Met Glu Tyr Lys Leu Ile Pro Gly Ser Lys Met Leu 
225                 230                 235                 240 


Pro Lys Val Phe Phe Ser Lys Lys Gly Ile Ser Thr Phe Gln Pro Ser 
                245                 250                 255     


Glu Glu Leu Leu Leu Asn Tyr Arg Ile Gly Thr Tyr Lys Lys Gly Glu 
            260                 265                 270         


Lys Phe Asn Leu Glu His Leu His Lys Leu Ile Asp Phe Tyr Lys His 
        275                 280                 285             


Ser Ile Ala Val His Glu Asp Trp Ser Lys Phe Asp Phe His Phe Ser 
    290                 295                 300                 


Asp Thr Ser Ser Tyr Arg Asp Ile Ser Gly Phe Tyr Lys Glu Val Glu 
305                 310                 315                 320 


Gln Gln Gly Tyr Lys Leu Thr Phe Arg Asn Val Ser Val Ser Tyr Ile 
                325                 330                 335     


Asn Arg Leu Val Glu Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn 
            340                 345                 350         


Lys Asp Phe Ser Glu Tyr Ser Lys Gly Thr Pro Asn Leu His Thr Leu 
        355                 360                 365             


Tyr Trp Lys Met Leu Phe Asp Pro Glu Asn Leu Lys Asp Val Val Tyr 
    370                 375                 380                 


Lys Leu Ser Gly Glu Ala Glu Val Phe Phe Arg Lys Lys Ser Leu Asp 
385                 390                 395                 400 


Val Ser His Pro Thr His Pro Lys Asn Glu Pro Ile Glu Lys Lys Asn 
                405                 410                 415     


Ile Asn Asn Lys Gly Glu Lys Ser Leu Phe Ser Tyr Asp Leu Ile Lys 
            420                 425                 430         


Asp Arg Arg Phe Thr Val Asp Lys Phe Gln Phe His Val Pro Ile Thr 
        435                 440                 445             


Met Asn Phe Lys Gly Glu Gln Gly Asp Arg Val Asn Gln Met Val Gln 
    450                 455                 460                 


Ser Tyr Val Arg Asn Asn Lys Gly Leu Asn Val Ile Gly Ile Asp Arg 
465                 470                 475                 480 


Gly Glu Arg Asn Leu Leu Tyr Leu Val Val Ile Asn Glu His Gly Glu 
                485                 490                 495     


Ile Leu Glu Gln Phe Ser Leu Asn Glu Ile Arg Asn Ala Tyr Asn Gly 
            500                 505                 510         


Lys Glu His Lys Ile Asp Tyr His Thr Leu Leu Glu Glu Arg Ser Lys 
        515                 520                 525             


Lys Arg Gln Asp Ala Arg Gln Ser Trp Gln Thr Ile Glu Gly Ile Lys 
    530                 535                 540                 


Asp Leu Lys Thr Gly Tyr Leu Ser Gln Val Ile His Val Ile Thr Gln 
545                 550                 555                 560 


Leu Met Val Lys Tyr Asn Ala Ile Val Val Leu Glu Asp Leu Asn Phe 
                565                 570                 575     


Gly Phe Lys Ser Ser Arg Gln Lys Phe Glu Gln Ser Val Tyr Gln Gln 
            580                 585                 590         


Phe Glu Arg Lys Leu Ile Asp Lys Leu Asn Phe Leu Val Asn Lys Lys 
        595                 600                 605             


Ala Ala Pro Asn Glu Val Gly Gly Leu Leu Asn Ala Tyr Gln Leu Thr 
    610                 615                 620                 


Ala Pro Leu Gly Asn Ser Arg Lys Met Gly Lys Gln Asn Gly Phe Leu 
625                 630                 635                 640 


Phe Tyr Val Pro Ala Trp His Thr Ser Lys Ile Asp Pro Arg Thr Gly 
                645                 650                 655     


Phe Val Asn Leu Leu Asp Thr Arg Tyr Glu Asn Val Ala Lys Ala Lys 
            660                 665                 670         


Glu Phe Phe Ala Lys Phe Ala Ser Ile Thr Tyr Asn Pro Glu Lys Lys 
        675                 680                 685             


Trp Phe Glu Phe Ala Phe Asp Tyr Lys Ala Phe Gly Asn Arg Ala Asp 
    690                 695                 700                 


Gly Ser Arg Thr Lys Trp Thr Ile Cys Ser Tyr Gly Glu Arg Ile Glu 
705                 710                 715                 720 


Thr Phe Arg Asn Pro Glu Asn Asn Asn Gln Trp Asp Thr Lys Ser Val 
                725                 730                 735     


Pro Leu Thr Glu Arg Leu Thr Glu Leu Phe Ser Lys Tyr Gly Ile Asp 
            740                 745                 750         


Tyr Thr Thr Asn Leu Lys Glu Gln Ile Leu Asn Gln Thr Asp Lys Ala 
        755                 760                 765             


Phe Phe Val Glu Leu Leu Gly Ala Leu Arg Leu Thr Leu Gln Leu Arg 
    770                 775                 780                 


Asn Ser Arg Lys Ser Thr Gly Glu Asp Phe Leu Phe Ser Pro Val Ala 
785                 790                 795                 800 


Asp Glu Asn Gly Cys Phe Phe Asp Ser Arg Glu Ala Asn Asp Asn Glu 
                805                 810                 815     


Pro Lys Asp Ala Asp Ala Asn Gly Ala Tyr His Ile Ala Leu Lys Gly 
            820                 825                 830         


Leu Trp Val Leu Asp Thr Ile Arg Asn Thr Glu Glu Gly Lys Asn Pro 
        835                 840                 845             


Lys Leu Ala Ile Thr Asn Lys Glu Trp Leu Ser Phe Ala Gln Ala Lys 
    850                 855                 860                 


Pro Phe Ala His Glu 
865                 


<210> 537
<211> 884
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 537
Met Ser Asp Ser Tyr Asp Glu Leu Thr Lys Ala Gln Lys Glu Lys Gln 
1               5                   10                  15      


Glu Lys Arg Lys His Val Ala Leu Thr Glu Val Val Ala Ala Leu Glu 
            20                  25                  30          


Lys Tyr Thr Ile Ala Leu Asp Asn Gly His Glu His Lys Asn Ala Val 
        35                  40                  45              


Asn Thr Phe Lys Asn Tyr Phe Gln Asn Tyr Phe Phe His Phe Asp Thr 
    50                  55                  60                  


Asp Lys Lys Lys Thr Ala Lys Thr Leu Asp Cys Gln Ile Lys Asp Glu 
65                  70                  75                  80  


Tyr Asn Gly Leu Lys Gly Ile Leu Asn Thr Pro Trp Asp Lys Asn Lys 
                85                  90                  95      


Lys Leu Gln Gln Asp Lys Lys Leu Val Gln Gln Ile Lys Ser Phe Leu 
            100                 105                 110         


Asp Ser Ile Gln Glu Leu Leu Trp Phe Ile Lys Pro Leu Val Leu Thr 
        115                 120                 125             


Asp Asn Thr Leu Glu Lys Asp Glu Arg Phe Tyr Gly Glu Phe Met Pro 
    130                 135                 140                 


Leu Tyr Asp Glu Ile Ser Asn Ile Ile Lys Leu Tyr Asn Lys Ile Arg 
145                 150                 155                 160 


Asn Tyr Leu Thr Lys Lys Pro Tyr Ser Ile Glu Lys Tyr Lys Leu Asn 
                165                 170                 175     


Phe Glu Asn Gly Ser Leu Leu Ser Gly Trp Asp Val Asn Lys Glu Lys 
            180                 185                 190         


Asp Asn Thr Ser Val Leu Leu Cys Lys Asp Asn Gln Tyr Tyr Leu Ala 
        195                 200                 205             


Ile Met His Ile Asp His Asn Lys Val Phe Glu Leu Asp Glu Leu Ile 
    210                 215                 220                 


Lys His Ala Gly Lys Gly Tyr Gln Lys Ile Asn Tyr Lys Leu Leu Pro 
225                 230                 235                 240 


Gly Ala Asn Lys Met Leu Pro Lys Val Phe Phe Ser Gly Lys Asn Ile 
                245                 250                 255     


Ser Tyr Tyr Asp Pro Ser Lys Glu Ile Leu Lys Ile Arg Asn Tyr Gly 
            260                 265                 270         


Thr His Thr Lys Asn Gly Asp Pro Gln Pro Gly Phe Ser Lys Arg Asp 
        275                 280                 285             


Phe Ser Val Asp Asp Cys Arg Lys Met Ile Asp Phe Phe Lys Asn Ser 
    290                 295                 300                 


Ile Ala Lys His Glu Asp Trp Lys Asn Phe Asp Phe Lys Phe Gln Pro 
305                 310                 315                 320 


Thr Lys Asn Tyr Asn Ser Ile Asp Glu Phe Tyr Arg Glu Val Glu Glu 
                325                 330                 335     


Gln Gly Tyr Lys Ile Thr Tyr Ser Asn Val Ser Glu Asp Tyr Ile Asp 
            340                 345                 350         


Ser Leu Val Glu Tyr Gly Lys Ile Tyr Leu Phe His Ile Tyr Asn Lys 
        355                 360                 365             


Asp Phe Ser Asp Lys Arg Asp Glu Ser Lys Lys His Thr Asp Asn Met 
    370                 375                 380                 


His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Ala Lys Asn Leu Lys Asp 
385                 390                 395                 400 


Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Ile Phe Tyr Arg Lys Lys 
                405                 410                 415     


Ser Ile Asp Ile Lys Lys Pro Thr His Glu Lys Gly Lys Pro Ile Asp 
            420                 425                 430         


Asn Lys Asn Pro Asn Ala Arg Lys Lys Thr Ser Val Phe Lys Tyr Asp 
        435                 440                 445             


Leu Ile Lys Asp Lys Arg Phe Thr Val Asp Lys Phe Phe Phe His Val 
    450                 455                 460                 


Pro Ile Thr Leu Asn Phe Lys Ser Lys Ser Gly Tyr Leu Ser Asn Asp 
465                 470                 475                 480 


Asp Val Asn Ala Ala Ile Lys Lys Asn Asn Asp Ile Lys Ile Ile Gly 
                485                 490                 495     


Leu Asp Arg Gly Glu Arg Asn Leu Ile Tyr Leu Ser Leu Ile Asn Ser 
            500                 505                 510         


Lys Gly Glu Ile Ala Tyr Gln Glu Ser Leu Asn Val Val Ser Thr Asp 
        515                 520                 525             


Lys Gly Phe Asp Val Asn Tyr His Lys Leu Leu Asp Asp Lys Glu Gly 
    530                 535                 540                 


Asn Arg Asp Glu Ala Arg Lys Asn Trp Asp Lys Ile Glu Asn Ile Lys 
545                 550                 555                 560 


Glu Leu Lys Ala Gly Tyr Leu Ser Gln Val Ile His Lys Ile Ala Lys 
                565                 570                 575     


Leu Met Ile Asp Asn Asn Ala Ile Val Val Met Glu Asp Leu Asn Phe 
            580                 585                 590         


Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln Ile Tyr Gln Lys 
        595                 600                 605             


Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Leu Val Phe Lys Asn 
    610                 615                 620                 


Val His Pro Glu Gln Ala Gly Gly Leu Tyr Lys Ala Tyr Gln Leu Thr 
625                 630                 635                 640 


Ala Gln Phe Glu Ser Phe Lys Lys Leu Gly Lys Gln Ser Gly Phe Leu 
                645                 650                 655     


Phe Tyr Ile Pro Ala Trp Asn Thr Ser Lys Ile Asp Pro Thr Ala Gly 
            660                 665                 670         


Phe Val Asp Phe Leu Lys Pro Arg Tyr Glu Ser Val Thr Gln Ala Lys 
        675                 680                 685             


Ser Phe Leu Gln Arg Phe Asp Lys Ile Asn Tyr Asn Lys Thr Lys Asp 
    690                 695                 700                 


Tyr Phe Glu Phe Ala Phe Asp Tyr Lys Asn Phe Thr Asp Lys Ala Asn 
705                 710                 715                 720 


Asp Thr Lys Thr Asp Trp Val Val Cys Thr Tyr Gly Thr Glu Arg Tyr 
                725                 730                 735     


Tyr Tyr Asp Val Arg Thr Lys Thr Thr Gln Lys Ile Asp Ile Thr Ala 
            740                 745                 750         


Glu Leu Lys Lys Leu Leu Glu Lys Ser Glu Ile Asn Tyr Leu Asn Gly 
        755                 760                 765             


Lys Asp Ile Lys Glu Leu Ile Ile Ala Val Asp Ser Lys Glu Phe His 
    770                 775                 780                 


Ser Ala Leu Leu Lys Tyr Leu Ala Ile Val Leu Ala Leu Arg Tyr Ser 
785                 790                 795                 800 


Asp Ser Gln Ser Gly Arg Asp Phe Ile Leu Ser Pro Val Ala Asn Glu 
                805                 810                 815     


Gln Gly His Phe Phe Asn Ser Asp Lys Thr Asp Asp Thr Leu Pro Lys 
            820                 825                 830         


Asp Ala Asp Ala Asn Gly Ala Tyr His Ile Ala Leu Lys Gly Leu Trp 
        835                 840                 845             


Ala Ile Asn Gln Ile Arg Lys Thr Lys Asn Gly Asp Lys Leu Lys Leu 
    850                 855                 860                 


Thr Ile Ser Asn Lys Asp Trp Leu Asn Phe Val Gln Lys Lys Glu Tyr 
865                 870                 875                 880 


Arg Lys Gly Val 
                


<210> 538
<211> 1250
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 538
Met Gln Thr Leu Phe Glu Asn Phe Thr Asn Gln Tyr Pro Val Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Lys Asp Phe Ile 
            20                  25                  30          


Glu Gln Lys Gly Leu Leu Lys Lys Asp Glu Asp Arg Ala Glu Lys Tyr 
        35                  40                  45              


Lys Lys Val Lys Asn Ile Ile Asp Glu Tyr His Lys Asp Phe Ile Glu 
    50                  55                  60                  


Lys Ser Leu Asn Gly Leu Lys Leu Asp Gly Leu Glu Lys Tyr Lys Thr 
65                  70                  75                  80  


Leu Tyr Leu Lys Gln Glu Lys Asp Asp Lys Asp Lys Lys Ala Phe Asp 
                85                  90                  95      


Lys Glu Lys Glu Asn Leu Arg Lys Gln Ile Ala Asn Ala Phe Arg Asn 
            100                 105                 110         


Asn Glu Lys Phe Lys Thr Leu Phe Ala Lys Glu Leu Ile Lys Asn Asp 
        115                 120                 125             


Leu Met Ser Phe Ala Cys Glu Glu Asp Lys Lys Asn Val Lys Glu Phe 
    130                 135                 140                 


Glu Ala Phe Thr Thr Tyr Phe Thr Gly Phe His Gln Asn Arg Ala Asn 
145                 150                 155                 160 


Met Tyr Val Ala Asp Glu Lys Arg Thr Ala Ile Ala Ser Arg Leu Ile 
                165                 170                 175     


His Glu Asn Leu Pro Lys Phe Ile Asp Asn Ile Lys Ile Phe Glu Lys 
            180                 185                 190         


Met Lys Lys Glu Ala Pro Glu Leu Leu Ser Pro Phe Asn Gln Thr Leu 
        195                 200                 205             


Lys Asp Met Lys Asp Val Ile Lys Gly Thr Thr Leu Glu Glu Ile Phe 
    210                 215                 220                 


Ser Leu Asp Tyr Phe Asn Lys Thr Leu Thr Gln Ser Gly Ile Asp Ile 
225                 230                 235                 240 


Tyr Asn Ser Val Ile Gly Gly Arg Thr Pro Glu Glu Gly Lys Thr Lys 
                245                 250                 255     


Ile Lys Gly Leu Asn Glu Tyr Ile Asn Thr Asp Phe Asn Gln Lys Gln 
            260                 265                 270         


Thr Asp Lys Lys Lys Arg Gln Pro Lys Phe Lys Gln Leu Tyr Lys Gln 
        275                 280                 285             


Ile Leu Ser Asp Arg Gln Ser Leu Ser Phe Ile Ala Glu Ala Phe Lys 
    290                 295                 300                 


Asn Asp Ala Glu Ile Leu Glu Ala Ile Glu Lys Phe Tyr Val Asn Glu 
305                 310                 315                 320 


Leu Leu His Phe Ser Asn Glu Gly Lys Ser Thr Asn Val Leu Asp Ala 
                325                 330                 335     


Ile Lys Asn Ala Val Ser Asn Leu Glu Ser Phe Asn Leu Thr Lys Met 
            340                 345                 350         


Tyr Phe Arg Ser Gly Thr Ser Leu Thr Asp Val Ser Arg Lys Val Phe 
        355                 360                 365             


Gly Glu Trp Ser Ile Ile Asn Arg Ala Leu Asp Asn Tyr Tyr Ala Thr 
    370                 375                 380                 


Thr Tyr Pro Ile Lys Pro Arg Glu Lys Ser Glu Lys Tyr Glu Glu Arg 
385                 390                 395                 400 


Lys Glu Lys Trp Leu Lys Gln Asp Phe Asn Val Arg Leu Ile Gln Thr 
                405                 410                 415     


Ala Ile Asp Glu Tyr Asp Asn Glu Thr Val Lys Gly Lys Asn Ser Gly 
            420                 425                 430         


Lys Val Ile Ala Asp Tyr Phe Ala Lys Phe Cys Asp Asp Lys Glu Thr 
        435                 440                 445             


Asp Leu Ile Gln Lys Val Asn Glu Gly Tyr Ile Ala Val Lys Asp Leu 
    450                 455                 460                 


Leu Asn Thr Pro Tyr Pro Glu Asn Glu Lys Ile Gly Ser Asn Lys Asp 
465                 470                 475                 480 


Gln Val Lys Gln Ile Lys Ala Phe Met Asp Ser Ile Met Asp Ile Met 
                485                 490                 495     


His Phe Val Arg Pro Leu Ser Leu Lys Asp Thr Asp Lys Glu Lys Asp 
            500                 505                 510         


Glu Thr Phe Tyr Ser Leu Phe Thr Pro Leu Tyr Asp His Leu Thr Gln 
        515                 520                 525             


Thr Ile Ala Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Gln Lys Pro 
    530                 535                 540                 


Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Glu Asn Ser Thr Leu Leu 
545                 550                 555                 560 


Gly Gly Trp Asp Leu Asn Lys Glu Thr Asp Asn Thr Ala Ile Ile Leu 
                565                 570                 575     


Arg Lys Asp Asn Leu Tyr Tyr Leu Gly Ile Met Asp Lys Arg His Asn 
            580                 585                 590         


Arg Ile Phe Arg Asn Val Pro Lys Ala Asp Lys Lys Asp Phe Cys Tyr 
        595                 600                 605             


Glu Lys Met Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro 
    610                 615                 620                 


Lys Val Phe Phe Ser Gln Ser Arg Ile Gln Glu Phe Thr Pro Ser Ala 
625                 630                 635                 640 


Lys Leu Leu Glu Asn Tyr Ala Asn Glu Thr His Lys Lys Gly Asp Asn 
                645                 650                 655     


Phe Asn Leu Asn His Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser 
            660                 665                 670         


Ile Asn Lys His Glu Asp Trp Lys Asn Phe Asp Phe Arg Phe Ser Ala 
        675                 680                 685             


Thr Ser Thr Tyr Ala Asp Leu Ser Gly Phe Tyr His Glu Val Glu His 
    690                 695                 700                 


Gln Gly Tyr Lys Ile Ser Phe Gln Ser Ile Ala Asp Ser Phe Ile Asp 
705                 710                 715                 720 


Asp Leu Val Asn Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
                725                 730                 735     


Asp Phe Ser Pro Phe Ser Lys Gly Lys Pro Asn Leu His Thr Leu Tyr 
            740                 745                 750         


Trp Lys Met Leu Phe Asp Glu Asn Asn Leu Lys Asp Val Val Tyr Lys 
        755                 760                 765             


Leu Asn Gly Glu Ala Glu Val Phe Tyr Arg Lys Lys Ser Ile Ala Glu 
    770                 775                 780                 


Lys Asn Thr Thr Ile His Lys Ala Asn Glu Ser Ile Ile Asn Lys Asn 
785                 790                 795                 800 


Pro Asp Asn Pro Lys Ala Thr Ser Thr Phe Asn Tyr Asp Ile Val Lys 
                805                 810                 815     


Asp Lys Arg Tyr Thr Ile Asp Lys Phe Gln Phe His Ile Pro Ile Thr 
            820                 825                 830         


Met Asn Phe Lys Ala Glu Gly Ile Phe Asn Met Asn Gln Arg Val Asn 
        835                 840                 845             


Gln Phe Leu Lys Ala Asn Pro Asp Ile Asn Ile Ile Gly Ile Asp Arg 
    850                 855                 860                 


Gly Glu Arg His Leu Leu Tyr Tyr Ala Leu Ile Asn Gln Lys Gly Lys 
865                 870                 875                 880 


Ile Leu Lys Gln Asp Thr Leu Asn Val Ile Ala Asn Glu Lys Gln Lys 
                885                 890                 895     


Val Asp Tyr His Asn Leu Leu Asp Lys Lys Glu Gly Asp Arg Ala Thr 
            900                 905                 910         


Ala Arg Gln Glu Trp Gly Val Ile Glu Thr Ile Lys Glu Leu Lys Glu 
        915                 920                 925             


Gly Tyr Leu Ser Gln Val Ile His Lys Leu Thr Asp Leu Met Ile Glu 
    930                 935                 940                 


Asn Asn Ala Ile Ile Val Met Glu Asp Leu Asn Phe Gly Phe Lys Arg 
945                 950                 955                 960 


Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met 
                965                 970                 975     


Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Asn Lys Lys Ala Asn 
            980                 985                 990         


Glu Leu Gly Gly Leu Leu Asn Ala  Phe Gln Leu Ala Asn  Lys Phe Glu 
        995                 1000                 1005             


Ser Phe  Gln Lys Met Gly Lys  Gln Asn Gly Phe Ile  Phe Tyr Val 
    1010                 1015                 1020             


Pro Ala  Trp Asn Thr Ser Lys  Thr Asp Pro Ala Thr  Gly Phe Ile 
    1025                 1030                 1035             


Asp Phe  Leu Lys Pro Arg Tyr  Glu Asn Leu Asn Gln  Ala Lys Asp 
    1040                 1045                 1050             


Phe Phe  Glu Lys Phe Asp Ser  Ile Arg Leu Asn Ser  Lys Ala Asp 
    1055                 1060                 1065             


Tyr Phe  Glu Phe Ala Phe Asn  Phe Lys Asn Phe Thr  Glu Lys Ala 
    1070                 1075                 1080             


Asp Gly  Gly Arg Thr Lys Trp  Thr Val Cys Thr Thr  Asn Glu Asp 
    1085                 1090                 1095             


Arg Tyr  Ala Trp Asn Arg Ala  Leu Asn Asn Asn Arg  Gly Ser Gln 
    1100                 1105                 1110             


Glu Lys  Tyr Asp Ile Thr Ala  Glu Leu Lys Ser Leu  Phe Asp Gly 
    1115                 1120                 1125             


Lys Val  Asp Tyr Lys Ser Gly  Lys Asp Leu Lys Gln  Gln Ile Ala 
    1130                 1135                 1140             


Ser Gln  Glu Ser Ala Asp Phe  Phe Lys Ala Leu Met  Lys Asn Leu 
    1145                 1150                 1155             


Ser Ile  Thr Leu Ser Leu Arg  His Asn Asn Gly Glu  Lys Gly Asp 
    1160                 1165                 1170             


Asn Glu  Gln Asp Tyr Ile Leu  Ser Pro Val Ala Asp  Ser Lys Gly 
    1175                 1180                 1185             


Arg Phe  Phe Asp Ser Arg Lys  Ala Asp Asp Asp Met  Pro Lys Asn 
    1190                 1195                 1200             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Trp 
    1205                 1210                 1215             


Cys Leu  Glu Gln Ile Ser Lys  Thr Asp Asp Leu Lys  Lys Val Lys 
    1220                 1225                 1230             


Leu Ala  Ile Ser Asn Lys Glu  Trp Leu Glu Phe Val  Gln Thr Leu 
    1235                 1240                 1245             


Lys Gly  
    1250 


<210> 539
<211> 810
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 539
Met Gln Leu Thr Asp Asn Leu Ser Asp Lys Tyr Lys Glu Ala Ala Pro 
1               5                   10                  15      


Leu Leu Asn Glu Asn Tyr Ser Asn Glu Lys Gly Leu Lys Asn Asp Asp 
            20                  25                  30          


Lys Ser Ile Ser Leu Ile Lys Asn Phe Leu Asp Ala Ile Lys Glu Ile 
        35                  40                  45              


Glu Lys Phe Ile Lys Pro Leu Ser Glu Thr Asn Ile Thr Gly Glu Lys 
    50                  55                  60                  


Asn Asp Leu Phe Tyr Ser Gln Phe Thr Pro Leu Leu Asp Asn Ile Ser 
65                  70                  75                  80  


Arg Ile Asp Ile Leu Tyr Asp Lys Val Arg Asn Tyr Val Thr Gln Lys 
                85                  90                  95      


Pro Phe Ser Thr Asp Lys Ile Lys Leu Asn Phe Gly Asn Ser Gln Leu 
            100                 105                 110         


Leu Asn Gly Trp Asp Arg Asn Lys Glu Lys Asp Cys Gly Ala Val Trp 
        115                 120                 125             


Leu Cys Lys Asp Glu Lys Tyr Tyr Leu Ala Ile Ile Asp Lys Ser Asn 
    130                 135                 140                 


Asn Ser Ile Leu Glu Asn Ile Asp Phe Gln Asp Cys Asp Glu Ser Asp 
145                 150                 155                 160 


Cys Tyr Glu Lys Ile Ile Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
                165                 170                 175     


Leu Pro Lys Val Phe Phe Ser Glu Lys Cys Lys Lys Leu Leu Ser Pro 
            180                 185                 190         


Ser Asp Glu Ile Leu Lys Ile Arg Lys Asn Gly Thr Phe Lys Lys Gly 
        195                 200                 205             


Asp Lys Phe Ser Leu Asp Asp Cys His Lys Leu Ile Asp Phe Tyr Lys 
    210                 215                 220                 


Glu Ser Phe Lys Lys Tyr Pro Asn Trp Leu Ile Tyr Asn Phe Lys Phe 
225                 230                 235                 240 


Lys Lys Thr Asn Glu Tyr Asn Asp Ile Arg Glu Phe Tyr Asn Asp Val 
                245                 250                 255     


Ala Ser Gln Gly Tyr Asn Ile Ser Lys Met Lys Ile Pro Thr Ser Phe 
            260                 265                 270         


Ile Asp Lys Leu Val Asp Glu Gly Lys Ile Tyr Leu Phe Gln Leu Tyr 
        275                 280                 285             


Asn Lys Asp Phe Ser Pro His Ser Lys Gly Thr Pro Asn Leu His Thr 
    290                 295                 300                 


Leu Tyr Phe Lys Met Leu Phe Asp Glu Arg Asn Leu Glu Asp Val Val 
305                 310                 315                 320 


Tyr Lys Leu Asn Gly Glu Ala Glu Met Phe Tyr Arg Pro Ala Ser Ile 
                325                 330                 335     


Lys Tyr Asp Lys Pro Thr His Pro Lys Asn Thr Pro Ile Lys Asn Lys 
            340                 345                 350         


Asn Thr Leu Asn Asp Lys Lys Thr Ser Ala Phe Pro Tyr Asp Leu Ile 
        355                 360                 365             


Lys Asp Lys Arg Tyr Thr Lys Trp Gln Phe Ser Leu His Phe Pro Ile 
    370                 375                 380                 


Thr Met Asn Phe Lys Ala Pro Asp Arg Ala Met Ile Asn Asp Asp Val 
385                 390                 395                 400 


Arg Asn Leu Leu Lys Ser Cys Asn Asn Asn Phe Ile Ile Gly Ile Asp 
                405                 410                 415     


Arg Gly Glu Arg Asn Leu Leu Tyr Val Ser Val Ile Asp Ser Asn Gly 
            420                 425                 430         


Thr Ile Ile Tyr Gln His Ser Leu Asn Ile Ile Gly Asn Lys Phe Lys 
        435                 440                 445             


Gly Lys Thr Tyr Lys Thr Asn Tyr Arg Glu Lys Leu Ala Thr Arg Glu 
    450                 455                 460                 


Lys Asp Arg Thr Glu Gln Arg Arg Asn Trp Lys Ala Ile Glu Ser Ile 
465                 470                 475                 480 


Lys Glu Leu Lys Glu Gly Tyr Ile Ser Gln Ala Val His Val Ile Cys 
                485                 490                 495     


Gln Leu Val Val Lys Tyr Asp Ala Ile Ile Val Met Glu Lys Leu Thr 
            500                 505                 510         


Glu Gly Phe Lys Arg Gly Arg Thr Lys Phe Glu Lys Gln Val Tyr Gln 
        515                 520                 525             


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Tyr Val Asp Lys 
    530                 535                 540                 


Lys Leu Asp Pro Asp Glu Glu Gly Gly Leu Leu His Ala Tyr Gln Leu 
545                 550                 555                 560 


Thr Asn Lys Leu Glu Ser Phe Asp Lys Leu Gly Thr Gln Ser Gly Phe 
                565                 570                 575     


Ile Phe Tyr Val Arg Pro Asp Phe Thr Ser Lys Ile Asp Pro Val Thr 
            580                 585                 590         


Gly Phe Val Asn Leu Leu Tyr Pro Arg Tyr Glu Asn Ile Asp Lys Ala 
        595                 600                 605             


Lys Asp Met Ile Ser Arg Phe Asp Glu Ile Arg Tyr Asn Ala Gly Glu 
    610                 615                 620                 


Asp Phe Phe Glu Phe Asp Ile Asp Tyr Asp Lys Phe Pro Lys Thr Ala 
625                 630                 635                 640 


Ser Asp Tyr Arg Lys Lys Trp Thr Ile Cys Thr Asn Gly Glu Arg Ile 
                645                 650                 655     


Glu Ala Phe Arg Asn Pro Ala Asn Asn Asn Glu Trp Ser Tyr Arg Thr 
            660                 665                 670         


Ile Ile Leu Ala Glu Lys Phe Lys Glu Leu Phe Asp Asn Asn Ser Ile 
        675                 680                 685             


Asn Tyr Arg Asp Ser Asp Asp Leu Lys Ala Glu Ile Leu Ser Gln Thr 
    690                 695                 700                 


Lys Gly Lys Phe Phe Glu Asp Phe Phe Lys Leu Leu Arg Leu Thr Leu 
705                 710                 715                 720 


Gln Met Arg Asn Ser Asn Pro Glu Thr Gly Glu Asp Arg Ile Leu Ser 
                725                 730                 735     


Pro Val Lys Asp Lys Asn Gly Asn Phe Tyr Asp Ser Ser Lys Tyr Asp 
            740                 745                 750         


Glu Lys Ser Lys Leu Pro Cys Asp Ala Asp Ala Asn Gly Ala Tyr Asn 
        755                 760                 765             


Ile Ala Arg Lys Gly Leu Trp Ile Val Glu Gln Phe Lys Lys Ala Asp 
    770                 775                 780                 


Asn Val Ser Thr Val Glu Pro Val Ile His Asn Asp Lys Trp Leu Lys 
785                 790                 795                 800 


Phe Val Gln Glu Asn Asp Met Thr Asn Asn 
                805                 810 


<210> 540
<211> 875
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 540
Met Leu Pro Asn Glu Lys Glu Arg Asn Glu Phe Lys Asn Ser Asn Ala 
1               5                   10                  15      


Lys Gln Tyr Ile Arg Glu Ile Ser Asn Ile Ile Thr Asp Thr Glu Thr 
            20                  25                  30          


Ala His Leu Glu Tyr Asp Glu His Ile Ser Leu Ile Glu Ser Glu Glu 
        35                  40                  45              


Lys Ala Asp Glu Met Lys Lys Arg Leu Asp Met Tyr Met Asn Met Tyr 
    50                  55                  60                  


His Trp Ala Lys Ala Phe Ile Val Asp Glu Val Leu Asp Arg Asp Glu 
65                  70                  75                  80  


Met Phe Tyr Ser Asp Ile Asp Asp Ile Tyr Asn Ile Leu Glu Asn Ile 
                85                  90                  95      


Val Pro Leu Tyr Asn Arg Val Arg Asn Tyr Val Thr Gln Lys Pro Tyr 
            100                 105                 110         


Asn Ser Lys Lys Ile Lys Leu Asn Phe Gln Ser Pro Thr Leu Ala Asn 
        115                 120                 125             


Gly Trp Ser Gln Ser Lys Glu Phe Asp Asn Asn Ala Ile Ile Leu Ile 
    130                 135                 140                 


Arg Asp Asn Lys Tyr Tyr Leu Ala Ile Phe Asn Ala Lys Asn Lys Pro 
145                 150                 155                 160 


Asp Lys Lys Ile Ile Gln Gly Asn Ser Asp Lys Lys Asn Asp Asn Asp 
                165                 170                 175     


Tyr Lys Lys Met Val Tyr Asn Leu Leu Pro Gly Ala Asn Lys Met Leu 
            180                 185                 190         


Pro Lys Val Phe Leu Ser Lys Lys Gly Ile Glu Thr Phe Lys Pro Ser 
        195                 200                 205             


Asp Tyr Ile Ile Ser Gly Tyr Asn Ala His Lys His Ile Lys Thr Ser 
    210                 215                 220                 


Glu Asn Phe Asp Ile Ser Phe Cys Arg Asp Leu Ile Asp Tyr Phe Lys 
225                 230                 235                 240 


Asn Ser Ile Glu Lys His Ala Glu Trp Arg Lys Tyr Glu Phe Lys Phe 
                245                 250                 255     


Ser Ala Thr Asp Ser Tyr Asn Asp Ile Ser Glu Phe Tyr Arg Glu Val 
            260                 265                 270         


Glu Met Gln Gly Tyr Arg Ile Asp Trp Thr Tyr Ile Ser Glu Ala Asp 
        275                 280                 285             


Ile Asn Lys Leu Asp Glu Glu Gly Lys Ile Tyr Leu Phe Gln Ile Tyr 
    290                 295                 300                 


Asn Lys Asp Phe Ala Glu Asn Ser Thr Gly Lys Glu Asn Leu His Thr 
305                 310                 315                 320 


Met Tyr Phe Lys Asn Ile Phe Ser Glu Glu Asn Leu Lys Asp Ile Ile 
                325                 330                 335     


Ile Lys Leu Asn Gly Gln Ala Glu Leu Phe Tyr Arg Arg Ala Ser Val 
            340                 345                 350         


Lys Asn Pro Val Lys His Lys Lys Asp Ser Val Leu Val Asn Lys Thr 
        355                 360                 365             


Tyr Lys Asn Gln Leu Asp Asn Gly Asp Val Val Arg Ile Pro Ile Pro 
    370                 375                 380                 


Asp Asp Ile Tyr Asn Glu Ile Tyr Lys Met Tyr Asn Gly Tyr Ile Lys 
385                 390                 395                 400 


Glu Asn Asp Leu Ser Glu Ala Ala Lys Glu Tyr Leu Asp Lys Val Glu 
                405                 410                 415     


Val Arg Thr Ala Gln Lys Asp Ile Val Lys Asp Tyr Arg Tyr Thr Val 
            420                 425                 430         


Asp Lys Tyr Phe Ile His Thr Pro Ile Thr Ile Asn Tyr Lys Val Thr 
        435                 440                 445             


Ala Arg Asn Asn Val Asn Asp Met Ala Val Lys Tyr Ile Ala Gln Asn 
    450                 455                 460                 


Asp Asp Ile His Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile 
465                 470                 475                 480 


Tyr Ile Ser Val Ile Asp Ser His Gly Asn Ile Val Lys Gln Lys Ser 
                485                 490                 495     


Tyr Asn Ile Leu Asn Asn Tyr Asp Tyr Lys Lys Lys Leu Val Glu Lys 
            500                 505                 510         


Glu Lys Thr Arg Glu Tyr Ala Arg Lys Asn Trp Lys Ser Ile Gly Asn 
        515                 520                 525             


Ile Lys Glu Leu Lys Glu Gly Tyr Ile Ser Gly Val Val His Glu Ile 
    530                 535                 540                 


Ala Met Leu Met Val Glu Tyr Asn Ala Ile Ile Ala Met Glu Asp Leu 
545                 550                 555                 560 


Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Arg Gln Val Tyr 
                565                 570                 575     


Gln Lys Phe Glu Ser Met Leu Ile Asn Lys Leu Asn Tyr Phe Ala Ser 
            580                 585                 590         


Lys Gly Lys Ser Val Asp Glu Pro Gly Gly Leu Leu Lys Gly Tyr Gln 
        595                 600                 605             


Leu Thr Tyr Val Pro Asp Asn Ile Lys Asn Leu Gly Lys Gln Cys Gly 
    610                 615                 620                 


Val Ile Phe Tyr Val Pro Ala Ala Phe Thr Ser Lys Ile Asp Pro Ser 
625                 630                 635                 640 


Thr Gly Phe Ile Ser Ala Phe Asn Phe Lys Ser Ile Ser Thr Asn Ala 
                645                 650                 655     


Ser Arg Lys Gln Phe Phe Met Gln Phe Asp Glu Ile Arg Tyr Cys Ala 
            660                 665                 670         


Glu Lys Asp Met Phe Ser Phe Gly Phe Asp Tyr Asn Asn Phe Asp Thr 
        675                 680                 685             


Tyr Asn Ile Thr Met Ser Lys Thr Gln Trp Thr Val Tyr Thr Asn Gly 
    690                 695                 700                 


Glu Arg Leu Gln Ser Glu Phe Asn Asn Ala Arg Arg Thr Gly Lys Thr 
705                 710                 715                 720 


Lys Ser Ile Asn Leu Thr Glu Thr Ile Lys Leu Leu Leu Glu Asp Asn 
                725                 730                 735     


Glu Ile Asn Tyr Ala Asp Gly His Asp Val Arg Ile Asp Met Glu Lys 
            740                 745                 750         


Met Asp Glu Asp Lys Asn Ser Glu Phe Phe Ala Gln Leu Leu Ser Leu 
        755                 760                 765             


Tyr Lys Leu Thr Val Gln Met Arg Asn Ser Tyr Thr Glu Ala Glu Glu 
    770                 775                 780                 


Gln Glu Lys Gly Ile Ser Tyr Asp Lys Ile Ile Ser Pro Val Ile Asn 
785                 790                 795                 800 


Asp Glu Gly Glu Phe Phe Asp Ser Asp Asn Tyr Lys Glu Ser Asp Asp 
                805                 810                 815     


Lys Glu Cys Lys Met Pro Lys Asp Ala Asp Ala Asn Gly Ala Tyr Cys 
            820                 825                 830         


Ile Ala Leu Lys Gly Leu Tyr Glu Val Leu Lys Ile Lys Ser Glu Trp 
        835                 840                 845             


Thr Glu Asp Gly Phe Asp Arg Asn Cys Leu Lys Leu Pro His Ala Glu 
    850                 855                 860                 


Trp Leu Asp Phe Ile Gln Asn Lys Arg Tyr Glu 
865                 870                 875 


<210> 541
<211> 1238
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 541
Met Ser Asn Leu Tyr Ser Asn Leu His Asn Leu Tyr Pro Val Gln Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Gln Gly Lys Thr Lys Glu Asn Met 
            20                  25                  30          


Glu Lys Ala Gly Ile Leu Lys Ala Asp Glu His Arg Ala Glu Val Tyr 
        35                  40                  45              


Gly Lys Val Lys Lys Tyr Cys Asp Glu Tyr His Lys Thr Phe Ile Asp 
    50                  55                  60                  


Arg Cys Leu Ser Asn Ile Glu Leu Asn Glu Ile Asp Lys Tyr Tyr Glu 
65                  70                  75                  80  


Leu Tyr Ser Ile Asn Asn Arg Asp Asp Lys Gln Lys Glu Glu Leu Asp 
                85                  90                  95      


Gln Leu Glu Thr Gly Leu Arg Lys Gln Ile Ser Asp Ala Phe Lys Lys 
            100                 105                 110         


Ser Ala Glu Tyr Lys Gly Leu Phe Gln Lys Asp Met Ile Thr Ser Tyr 
        115                 120                 125             


Leu Val Thr Met Tyr Lys Glu Asn Gln Glu Lys Met Gln Asp Ile Gly 
    130                 135                 140                 


Glu Phe Asn Arg Phe Thr Thr Tyr Phe Thr Gly Tyr Asn Lys Asn Arg 
145                 150                 155                 160 


Glu Asn Met Tyr Ser Glu Glu Asp Lys Ser Thr Ala Ile Ser Tyr Arg 
                165                 170                 175     


Leu Ile Asn Glu Asn Leu Pro Thr Phe Ile Asp Asn Ile Lys Ile Tyr 
            180                 185                 190         


Lys Lys Ile Val Ser Leu Met Pro Glu Asn Ile Glu Lys Ile Tyr Lys 
        195                 200                 205             


Asp Leu Glu Glu Tyr Ile Gln Val Asn Ser Val Asp Glu Ile Phe Asn 
    210                 215                 220                 


Ile Ser Tyr Tyr Asn Asp Val Leu Thr Gln Arg Gly Ile Glu Cys Tyr 
225                 230                 235                 240 


Asn Ile Leu Ile Ser Gly Arg Thr Lys Asn Asp Gly Asp Lys Ile Lys 
                245                 250                 255     


Gly Leu Asn Glu Tyr Ile Asn Glu Phe Asn Gln Thr His Asn Glu Lys 
            260                 265                 270         


Ile Pro Lys Leu Gln Glu Leu Tyr Lys Gln Ile Leu Ser Asp Ala Glu 
        275                 280                 285             


Ser Ala Ser Phe Lys Val Asp Ile Ile Glu Asn Asp Lys Glu Leu Leu 
    290                 295                 300                 


Asn Leu Ile Glu Val Tyr Tyr Ala Asn Ile Leu Pro Thr Leu Asn Lys 
305                 310                 315                 320 


Ile Glu Asp Leu Phe Thr Arg Ile Ser Asn Tyr Asn Leu Glu Leu Ile 
                325                 330                 335     


Leu Val Asn Asn Asp Gly Ser Leu Ser Thr Leu Ser Asn Met Val Phe 
            340                 345                 350         


Asn Glu Trp Ser Tyr Ile Lys Gly Ile Ile Ser Gln Lys Tyr Asp Ala 
        355                 360                 365             


Glu Tyr Ser Gly Lys Glu Lys Tyr Gly Thr Glu Lys Tyr Ala Gln Lys 
    370                 375                 380                 


Lys Gln Glu Tyr Leu Lys Lys Gln Lys Ile Tyr Ser Leu Lys Phe Leu 
385                 390                 395                 400 


Asn Asp Cys Ile Gly Asn Asn Ala Ile Cys Glu Tyr Leu Lys Asn Tyr 
                405                 410                 415     


Ile Ile Gln Asn Lys Asn Ile Glu Thr Ile Lys Glu Asp Tyr Asn Glu 
            420                 425                 430         


Val Gln Asn Ile Lys Ala Glu Asp Asp Thr Lys Glu Leu Ile Lys Asp 
        435                 440                 445             


Glu Lys Ser Ile Glu Lys Ile Lys Lys Phe Leu Asp Asp Val Lys Ser 
    450                 455                 460                 


Leu Gln Glu Phe Val Lys Leu Val Ile Pro Lys Asp Arg Thr Val Glu 
465                 470                 475                 480 


Lys Asp Ala Lys Phe Tyr Ser Glu Leu Thr Pro Tyr Tyr Glu Lys Ile 
                485                 490                 495     


Lys Glu Ile Ile Pro Leu Tyr Asn Lys Val Arg Asn Tyr Val Thr Gln 
            500                 505                 510         


Lys Pro Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Glu Cys Pro Thr 
        515                 520                 525             


Leu Leu Asn Gly Trp Asp Ala Asn Lys Glu Glu Ala Asn Leu Gly Val 
    530                 535                 540                 


Ile Leu Leu Lys Glu Gly Lys Tyr Tyr Leu Gly Ile Met Asn Pro Tyr 
545                 550                 555                 560 


Cys Lys Lys Ile Phe Glu Val Tyr Glu Lys Asp Ser Asn Glu Gln Asn 
                565                 570                 575     


Asn Tyr Lys Lys Met Glu Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Asn Ser Arg Ile Glu Glu Phe Asn Pro 
        595                 600                 605             


Ser Lys Glu Leu Gln Glu Lys Tyr Asn Lys Gly Tyr His Lys Lys Gly 
    610                 615                 620                 


Lys Asp Phe Asp Ile Asn Phe Cys His Glu Leu Ile Asp Phe Tyr Lys 
625                 630                 635                 640 


Gln Ser Leu Asn Lys His Glu Asp Trp Lys Lys Phe Asn Phe Lys Phe 
                645                 650                 655     


Lys Asp Thr Ser Glu Tyr Asn Asp Ile Ser Glu Phe Tyr Arg Glu Val 
            660                 665                 670         


Glu Glu Gln Gly Tyr Lys Ile Glu Tyr Thr Glu Tyr Ser Glu Lys Tyr 
        675                 680                 685             


Ile Asn Glu Leu Val Asp Arg Gly Glu Leu Tyr Leu Phe Gln Ile Tyr 
    690                 695                 700                 


Asn Lys Asp Phe Ser Glu Tyr Ser Lys Gly Lys Glu Asn Leu His Thr 
705                 710                 715                 720 


Leu Tyr Trp Lys Ala Val Phe Asp Pro Asp Asn Ile Met Asn Pro Val 
                725                 730                 735     


Tyr Lys Leu Asn Gly Asn Ala Glu Ile Phe Tyr Arg Lys Lys Ser Leu 
            740                 745                 750         


Glu Met Lys Val Thr His Pro Ala Asn Gln Pro Ile Ala Asn Lys Asn 
        755                 760                 765             


Ile Ser Thr Ile Glu Ala Gly Arg Ser Thr Ser Thr Phe Lys Tyr Asp 
    770                 775                 780                 


Leu Ile Lys Asp Lys Arg Tyr Thr Met Asp Lys Phe Gln Phe His Val 
785                 790                 795                 800 


Pro Ile Thr Val Asn Phe Lys Ser Glu Arg Leu Phe Asn Ile Asn Gln 
                805                 810                 815     


Ile Val Asn Lys Tyr Leu Lys Tyr Asn Asp Asp Ile His Val Ile Gly 
            820                 825                 830         


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Val Cys Val Ile Asp Lys 
        835                 840                 845             


Asn Glu Lys Ile Val Tyr Gln Lys Ser Leu Asn Glu Ile Val Ser Glu 
    850                 855                 860                 


Tyr Asn Asn Asn Arg Tyr Thr Thr Asp Tyr His Gly Leu Leu Asp Arg 
865                 870                 875                 880 


Lys Glu Lys Glu Arg Glu Ile Ala Arg Glu Asp Trp Lys Asn Ile Glu 
                885                 890                 895     


Asn Ile Lys Glu Leu Lys Glu Gly Tyr Met Ser Gln Ile Ile His Ile 
            900                 905                 910         


Leu Val Glu Leu Met Lys Lys Tyr Asn Ala Ile Ile Val Ile Glu Asp 
        915                 920                 925             


Leu Asn Lys Gly Phe Lys Asn Ser Arg Ile Lys Val Glu Lys Gln Val 
    930                 935                 940                 


Tyr Gln Lys Phe Glu Lys Met Phe Ile Asp Lys Leu Asn Tyr Leu Val 
945                 950                 955                 960 


Phe Lys Asp Glu Asp Lys Met Asp Glu Gly Gly Val Leu Asn Ala Tyr 
                965                 970                 975     


Gln Leu Thr Asn Lys Phe Glu Ser Phe Thr Lys Leu Gly Lys Gln Ser 
            980                 985                 990         


Gly Ile Leu Tyr Tyr Ile Pro Ala  Trp Cys Thr Ser Lys  Ile Asp Pro 
        995                 1000                 1005             


Thr Thr  Gly Phe Ile Asn Arg  Phe Tyr Leu Lys Tyr  Glu Asn Phe 
    1010                 1015                 1020             


Asp Lys  Ser Lys Glu Phe Val  Asn Arg Ile Asp Asp  Ile Arg Tyr 
    1025                 1030                 1035             


Asn Glu  Lys Glu Asn Leu Phe  Glu Phe Asp Ile Asp  Tyr Ser Lys 
    1040                 1045                 1050             


Phe Thr  Asp Arg Leu Asn Asp  Thr Lys Asn Lys Trp  Thr Leu Cys 
    1055                 1060                 1065             


Ser Tyr  Gly Glu Arg Ile Leu  Thr Gln Lys Asn Ala  Asn Gly Glu 
    1070                 1075                 1080             


Trp Phe  Asp Arg Arg Ile Gln  Leu Ser Ile Glu Phe  Lys Asn Leu 
    1085                 1090                 1095             


Phe Glu  Lys Tyr Val Ile Asn  Leu Asn Asn Ile Lys  Asp Ser Ile 
    1100                 1105                 1110             


Leu Lys  Leu Asp Lys Asp Asn  Ile Glu Phe Tyr Lys  Gly Asn Gly 
    1115                 1120                 1125             


Glu Asn  Leu Gly Phe Ile Gln  Leu Phe Lys Leu Met  Val Gln Met 
    1130                 1135                 1140             


Arg Asn  Ser Leu Thr Gly Lys  Glu Glu Asp Asn Leu  Ile Ser Pro 
    1145                 1150                 1155             


Val Lys  Asn Gln His Gly Lys  Phe Phe Asn Thr Ser  Glu Arg Val 
    1160                 1165                 1170             


Glu Gly  Leu Pro Ile Asp Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Gly Phe Met Leu  Val Glu Gln Met Lys  Asn Val Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asn Lys Ile  Lys Tyr Asn Ile Thr  Glu Lys Glu 
    1205                 1210                 1215             


Trp Leu  Asn Tyr Val Gln Asn  Arg Gly Met Trp Trp  Lys Arg Gln 
    1220                 1225                 1230             


Tyr Leu  Tyr His Ile 
    1235             


<210> 542
<211> 1262
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 542
Met Ala Lys Asn Thr Ile Phe Ser Gln Phe Thr Gly Leu Tyr Pro Val 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Met Gly Lys Thr Leu Glu 
            20                  25                  30          


Lys Ile Lys Glu Thr Gly Val Ile Glu Asn Asp Lys Lys Arg His Asn 
        35                  40                  45              


Asp Tyr Phe Asp Ala Lys Lys Ile Ile Asp Lys Tyr His Lys Tyr Phe 
    50                  55                  60                  


Ile Asp Ala Ala Leu Ser Lys Phe Pro Arg Ile Asp Trp Ser Pro Leu 
65                  70                  75                  80  


Lys Glu Ala Ile Glu Arg Ser Leu Asp Arg Ser Asp Ala Ser Lys Lys 
                85                  90                  95      


Lys Leu Glu Lys Thr Gln Thr Glu Phe Arg Lys Lys Ile Ala Lys Ala 
            100                 105                 110         


Leu Thr Thr His Asp His Tyr Lys Glu Leu Thr Ala Ser Thr Pro Lys 
        115                 120                 125             


Asp Leu Phe Leu Lys Val Phe Pro Asp His Phe Gly Lys Gln Pro Ala 
    130                 135                 140                 


Ile Asp Thr Phe Asp Gly Phe Ser Ser Tyr Phe Thr Gly Phe Gln Glu 
145                 150                 155                 160 


Asn Arg Gln Asn Ile Tyr Ser Asp Glu Ala Ile Ser Thr Ala Ile Pro 
                165                 170                 175     


Tyr Arg Leu Val His Asp Asn Phe Pro Lys Phe Leu Ser Asn Ile Glu 
            180                 185                 190         


Val Tyr Lys Thr Leu Lys Asp Asn Ala Pro Ser Val Leu Ser Asp Ala 
        195                 200                 205             


Glu Asn Glu Leu Arg Asp Phe Leu Asn Gly Lys Ser Leu Ala Asn Ile 
    210                 215                 220                 


Phe Glu Leu Asn Ala Tyr Asn Glu Val Leu Thr Gln Ser Gly Ile Asp 
225                 230                 235                 240 


Phe Phe Asn Gln Val Ile Gly Gly Ile Ser Asp Glu Gly Gly Glu Lys 
                245                 250                 255     


Lys Thr Arg Gly Ile Asn Glu Phe Ser Asn Leu Tyr Arg Gln Gln His 
            260                 265                 270         


Pro Glu Phe Ala Gln Lys Arg Leu Ala Thr Lys Met Ile Pro Leu Tyr 
        275                 280                 285             


Lys Gln Ile Leu Ser Asp Arg Glu Thr Lys Ser Phe Ile Leu Glu Ser 
    290                 295                 300                 


Tyr Ser Asn Asp Ser Gln Val Gln Asn Ser Val Lys Glu Phe Phe Glu 
305                 310                 315                 320 


Ser Gln Ile Leu Asn Trp Asp Ile Ala Gly Arg Arg Val Asn Val Leu 
                325                 330                 335     


Asn Glu Leu Thr Ser Leu Val Lys Arg Ile Ser Glu Phe Asp Leu Gly 
            340                 345                 350         


Asn Ile Tyr Val Asn Gln Glu Glu Leu Ser Asn Ile Ser Leu Lys Leu 
        355                 360                 365             


Phe Asp Asn Trp Asn Ser Ile Asn Gly Leu Leu Phe Lys His Ala Glu 
    370                 375                 380                 


Asn Arg Ile Gly Ser Ala Glu Lys Ser Ala Asn Lys Lys Lys Ile Asp 
385                 390                 395                 400 


Ala Trp Met Lys Asn Lys Glu Phe Ser Ile Ala Thr Leu Asn Leu Ala 
                405                 410                 415     


Ile Ala Glu Ser Asn Ser Glu Glu Ile Ser Arg Val Lys Ile Glu Ser 
            420                 425                 430         


Tyr Trp Asn Asn Phe Glu Ala Lys Val Gln Ser Ile Leu Cys Gly Asp 
        435                 440                 445             


Asn Arg Arg Asn Leu Asp Glu Phe Ile Ser Ala Thr Phe Asn Glu Asn 
    450                 455                 460                 


Asn Ala Leu Arg Glu Asp Ser Lys Ile Ile Glu Lys Leu Lys Ala Phe 
465                 470                 475                 480 


Leu Asp Ala Leu Ile Glu Ile Met His Ser Ile Lys Pro Leu Ile Ser 
                485                 490                 495     


Asp Ala Glu Asn Arg Asp Leu Ser Phe Tyr Asn Glu Leu Ile Pro Leu 
            500                 505                 510         


Tyr Asp Gln Leu Ser Leu Val Val Pro Leu Tyr Asn Lys Ile Arg Asn 
        515                 520                 525             


Tyr Ala Thr Gln Lys Leu Thr Glu Ser Glu Lys Phe Lys Leu Asn Phe 
    530                 535                 540                 


Asp Asn Pro Thr Leu Ala Asp Gly Trp Asp Gln Asn Lys Glu Glu Ala 
545                 550                 555                 560 


Asn Thr Ala Ile Leu Leu Leu Lys Asn Gly Leu Tyr Tyr Leu Gly Ile 
                565                 570                 575     


Met Asn Ala Lys Asn Lys Pro Lys Ile Lys Asp Phe Lys Thr Ser Glu 
            580                 585                 590         


Ser Glu Asp Cys Tyr Asp Lys Met Val Tyr Lys Leu Leu Pro Gly Pro 
        595                 600                 605             


Asn Lys Met Leu Pro Lys Val Phe Phe Ser Glu Lys Gly Leu Ala Thr 
    610                 615                 620                 


Phe Lys Pro Pro Lys Asp Ile Leu Asp Gly Tyr Asn Ala Gly Lys His 
625                 630                 635                 640 


Lys Lys Gly Asp Leu Phe Asp Ile Gly Phe Cys His Gln Leu Ile Asp 
                645                 650                 655     


Phe Phe Lys Glu Ser Ile Ala Lys His Pro Asp Trp Lys Lys Phe Asp 
            660                 665                 670         


Phe Asn Phe Ser Asp Thr Ser Ser Tyr Glu Asp Ile Ser Gly Phe Tyr 
        675                 680                 685             


Lys Glu Val Thr Asp Gln Gly Tyr Lys Ile Thr Phe Ser Lys Ile Pro 
    690                 695                 700                 


Thr Ser Gln Ile Asp Glu Trp Val Lys Glu Gly Lys Leu Phe Leu Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ala Pro Gly Ala Lys Gly Ser Pro Asn 
                725                 730                 735     


Leu His Thr Leu Tyr Trp Lys Ser Val Phe Ser Pro Glu Asn Leu Lys 
            740                 745                 750         


Asp Val Val Val Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr Arg Pro 
        755                 760                 765             


Ser Ser Val Lys Lys Pro Tyr Ser His Lys Val Gly Glu Lys Leu Val 
    770                 775                 780                 


Asn Arg Ile Gly Lys Asp Gly Leu Pro Leu Pro Glu Ser Val Phe Gly 
785                 790                 795                 800 


Glu Leu Phe Arg Tyr Phe Asn Gly Lys Leu Glu Gly Glu Leu Ser Asp 
                805                 810                 815     


Glu Ala Lys Arg Tyr Leu Asp Val Ala Val Val Lys Asp Val Lys His 
            820                 825                 830         


Glu Ile Val Lys Asp Arg Arg Tyr Thr Gln Asp Lys Phe Glu Phe His 
        835                 840                 845             


Val Pro Leu Thr Leu Asn Phe Lys Ala Asp Ser Lys Asn Glu Tyr Met 
    850                 855                 860                 


Asn Glu Arg Val Arg His Phe Leu Lys Asp Asn Pro Asp Val Asn Ile 
865                 870                 875                 880 


Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Met Thr Leu Ile 
                885                 890                 895     


Asn Gln Lys Gly Glu Ile Leu Lys Gln Lys Ser Phe Asn Val Val Glu 
            900                 905                 910         


Ser Val Asn Tyr Gln Ala Lys Leu Val Gln Arg Glu Lys Glu Arg Asp 
        915                 920                 925             


Ala Ala Arg Arg Ser Trp Ser Ser Val Gly Lys Ile Lys Asp Leu Lys 
    930                 935                 940                 


Glu Gly Phe Leu Ser Gln Val Ile His Glu Ile Thr Thr Thr Met Ile 
945                 950                 955                 960 


Glu Asn Asn Ala Ile Val Val Leu Glu Asp Leu Asn Phe Gly Phe Lys 
                965                 970                 975     


Arg Gly Arg Phe Cys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys 
            980                 985                 990         


Met Leu Ile Asp Lys Leu Asn Tyr  Leu Val Phe Lys Asn  Lys Pro Glu 
        995                 1000                 1005             


Gly Asp  Val Gly Gly Val Leu  Lys Gly Tyr Gln Leu  Ala Glu Lys 
    1010                 1015                 1020             


Phe Asp  Ser Phe Gln Lys Leu  Gly Lys Gln Ser Gly  Phe Leu Phe 
    1025                 1030                 1035             


Tyr Ile  Pro Ala Ala Tyr Thr  Ser Lys Ile Asp Pro  Thr Thr Gly 
    1040                 1045                 1050             


Phe Ala  Asn Leu Phe Asn Met  Thr Glu Leu Thr Ser  Ala Glu Lys 
    1055                 1060                 1065             


Lys Lys  Glu Phe Leu Ser His  Phe Glu Asp Ile Thr  Tyr Asp Gly 
    1070                 1075                 1080             


Lys Asn  Asp Arg Phe Leu Phe  Ser Phe Asp Tyr Lys  Asn Phe Lys 
    1085                 1090                 1095             


Cys Phe  Gln Thr Asp Tyr Ile  Lys Lys Trp Thr Val  Tyr Ser Gln 
    1100                 1105                 1110             


Gly Lys  Arg Ile Val Tyr Asp  Lys Glu Ser Lys Ser  Ala Lys Glu 
    1115                 1120                 1125             


Ile Ser  Pro Val Glu Ile Ile  Lys Ala Ala Leu Ala  Lys Gln Asn 
    1130                 1135                 1140             


Ile Ala  Leu Thr Asp Gln Leu  Asp Val Leu Ser Ala  Ile Asn Ser 
    1145                 1150                 1155             


Val Glu  Ala Ser Pro Lys Ser  Ala Ser Phe Phe Gly  Asp Ile Cys 
    1160                 1165                 1170             


Tyr Ala  Phe Glu Lys Thr Leu  Gln Met Arg Asn Ser  Ile Pro Asn 
    1175                 1180                 1185             


Thr Asp  Glu Asp Tyr Leu Ala  Ser Pro Val Met Asn  Lys Arg Gly 
    1190                 1195                 1200             


Glu Phe  Tyr Asp Ser Arg Ser  Cys Asp Asp Ala Leu  Pro Gln Asn 
    1205                 1210                 1215             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Tyr 
    1220                 1225                 1230             


Leu Ile  Lys Asn Val Phe Asp  Ala Gly Gly Lys Glu  Leu Lys Ile 
    1235                 1240                 1245             


Ser His  Glu Asp Trp Phe Lys  Phe Ala Gln Ser Arg  Asn Cys 
    1250                 1255                 1260         


<210> 543
<211> 1140
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 543
Met Tyr Lys Asp Lys Thr Asp Lys Thr Lys Ile Ile Asp Ser Asp Leu 
1               5                   10                  15      


Ile Lys Phe Ile Asn Ile Ala Glu Ser Thr Gln Leu Asp Ser Met Ser 
            20                  25                  30          


Gln Asp Glu Ala Lys Glu Leu Val Lys Glu Phe Trp Gly Phe Thr Thr 
        35                  40                  45              


Tyr Phe Val Gly Phe Tyr Asp Asn Arg Lys Asn Met Tyr Thr Ala Glu 
    50                  55                  60                  


Glu Lys Ser Thr Gly Ile Ala Tyr Arg Leu Val Asn Glu Asn Leu Pro 
65                  70                  75                  80  


Lys Phe Ile Asp Asn Met Glu Ala Phe Lys Lys Ala Ile Ala Arg Pro 
                85                  90                  95      


Glu Ile Gln Ala Asn Met Glu Glu Leu Tyr Ser Asp Phe Ser Glu Tyr 
            100                 105                 110         


Leu Asn Val Glu Ser Val Gln Glu Met Phe Gln Leu Asp Tyr Tyr Asn 
        115                 120                 125             


Met Leu Leu Thr Gln Lys Gln Ile Asp Val Tyr Asn Ala Ile Ile Gly 
    130                 135                 140                 


Gly Lys Thr Asp Asp Glu His Asp Val Lys Ile Lys Gly Ile Asn Glu 
145                 150                 155                 160 


Tyr Ile Asn Leu Tyr Asn Gln Gln His Lys Asp Asp Lys Leu Pro Lys 
                165                 170                 175     


Leu Lys Ala Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Ala Ile Ser 
            180                 185                 190         


Trp Leu Pro Glu Glu Phe Asn Gly Asp Gln Glu Val Leu Asn Ala Ile 
        195                 200                 205             


Lys Asp Cys Tyr Glu Arg Leu Ser Glu Asn Val Leu Gly Asp Lys Val 
    210                 215                 220                 


Leu Lys Ser Leu Leu Gly Ser Leu Ser Asp Tyr Ser Leu Asp Gly Ile 
225                 230                 235                 240 


Phe Ile Arg Asn Asp Leu Gln Leu Thr Asp Ile Ser Gln Lys Met Phe 
                245                 250                 255     


Gly Asn Trp Cys Val Ile Gln Asn Ala Ile Met Gln Asn Ile Lys His 
            260                 265                 270         


Val Ala Pro Ala Arg Lys His Lys Glu Ser Glu Glu Asp Tyr Glu Lys 
        275                 280                 285             


Arg Ile Ala Gly Ile Phe Lys Lys Val Asp Ser Phe Ser Ile Ser Phe 
    290                 295                 300                 


Ile Asn Asp Cys Leu Asn Glu Ala Asp Pro Asn Asn Ala Tyr Phe Val 
305                 310                 315                 320 


Glu Asn Tyr Phe Ala Thr Phe Gly Ala Val Asn Thr Pro Thr Met Gln 
                325                 330                 335     


Arg Glu Asn Leu Phe Ala Leu Val Gln Asn Ala Tyr Thr Glu Val Ala 
            340                 345                 350         


Ala Leu Leu His Ser Asp Tyr Pro Thr Ala Lys His Leu Ala Gln Asp 
        355                 360                 365             


Lys Val Asn Val Ala Lys Ile Lys Ala Leu Leu Asp Ala Ile Lys Ser 
    370                 375                 380                 


Leu Gln His Phe Val Lys Pro Leu Leu Gly Lys Gly Asp Glu Ser Asp 
385                 390                 395                 400 


Lys Asp Glu Arg Phe Tyr Gly Glu Leu Ala Ser Leu Trp Ala Glu Leu 
                405                 410                 415     


Asp Thr Val Thr Pro Leu Tyr Asn Met Ile Arg Asn Tyr Met Thr Arg 
            420                 425                 430         


Lys Pro Tyr Ser Gln Lys Lys Ile Lys Leu Asn Phe Glu Asn Pro Gln 
        435                 440                 445             


Leu Leu Gly Gly Trp Asp Ala Asn Lys Glu Lys Asp Tyr Ala Thr Ile 
    450                 455                 460                 


Ile Leu Arg Arg Asp Gly Leu Tyr Tyr Leu Ala Ile Met Asn Lys Glu 
465                 470                 475                 480 


Ser Lys Lys Leu Leu Gly Lys Ala Met Pro Ser Asp Gly Glu Cys Tyr 
                485                 490                 495     


Glu Lys Met Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro 
            500                 505                 510         


Lys Val Phe Phe Ala Lys Ser Arg Met Glu Asp Phe Lys Pro Ser Lys 
        515                 520                 525             


Glu Leu Val Glu Lys Tyr Asn Asn Gly Thr His Lys Lys Gly Lys Asn 
    530                 535                 540                 


Phe Asn Ile Gln Asp Cys His Asn Leu Ile Asp Tyr Phe Lys Gln Ser 
545                 550                 555                 560 


Ile Ser Lys His Glu Asp Trp Gly Lys Phe Gly Phe Asn Phe Ser Asp 
                565                 570                 575     


Thr Ser Thr Tyr Glu Asp Leu Ser Gly Phe Tyr Arg Glu Val Glu Gln 
            580                 585                 590         


Gln Gly Tyr Lys Leu Ser Phe Ala Arg Val Ser Val Ser Tyr Ile Ser 
        595                 600                 605             


Gln Leu Val Glu Glu Gly Lys Met Tyr Leu Phe Gln Ile Tyr Asn Lys 
    610                 615                 620                 


Asp Phe Ser Glu Tyr Ser Lys Gly Thr Pro Asn Met His Thr Leu Tyr 
625                 630                 635                 640 


Trp Lys Ala Leu Phe Asp Glu Arg Asn Leu Ala Asp Val Val Tyr Lys 
                645                 650                 655     


Leu Asn Gly Gln Ala Glu Met Phe Tyr Arg Lys Lys Ser Ile Glu Asn 
            660                 665                 670         


Thr His Pro Thr His Pro Ala Asn His Pro Ile Leu Asn Lys Asn Lys 
        675                 680                 685             


Asp Asn Lys Lys Lys Glu Ser Leu Phe Asp Tyr Asp Leu Ile Lys Asp 
    690                 695                 700                 


Arg Arg Tyr Thr Val Asp Lys Phe Met Phe His Val Pro Ile Thr Met 
705                 710                 715                 720 


Asn Phe Lys Ser Ser Gly Ser Glu Asn Ile Asn Gln Asp Val Lys Ala 
                725                 730                 735     


Tyr Leu Arg His Ala Asp Asp Met His Ile Ile Gly Ile Asp Arg Gly 
            740                 745                 750         


Glu Arg His Leu Leu Tyr Leu Val Val Ile Asp Leu Gln Gly Asn Ile 
        755                 760                 765             


Lys Glu Gln Tyr Ser Leu Asn Glu Ile Val Asn Glu Tyr Asn Gly Asn 
    770                 775                 780                 


Thr Tyr His Thr Asn Tyr His Asp Leu Leu Asp Val Cys Glu Glu Glu 
785                 790                 795                 800 


Arg Leu Lys Ala Arg Gln Ser Trp Gln Thr Ile Glu Asn Ile Lys Glu 
                805                 810                 815     


Leu Lys Glu Gly Tyr Leu Ser Gln Val Ile His Lys Ile Thr Gln Leu 
            820                 825                 830         


Met Val Lys Tyr His Ala Ile Val Val Leu Glu Asp Leu Asn Met Gly 
        835                 840                 845             


Phe Met Arg Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe 
    850                 855                 860                 


Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Lys Ala 
865                 870                 875                 880 


Asp Ala Ser Val Ser Gly Gly Leu Leu Asn Ala Tyr Gln Leu Thr Ser 
                885                 890                 895     


Lys Phe Asp Ser Phe Gln Lys Leu Gly Lys Gln Ser Gly Phe Leu Phe 
            900                 905                 910         


Tyr Ile Pro Ala Trp Asn Thr Ser Lys Ile Asp Pro Val Thr Gly Phe 
        915                 920                 925             


Val Asn Leu Leu Asp Thr Arg Tyr Gln Asn Val Glu Lys Ala Lys Val 
    930                 935                 940                 


Phe Phe Ser Lys Phe Asp Ala Ile Arg Tyr Asn Lys Asp Lys Asp Trp 
945                 950                 955                 960 


Phe Glu Phe Asn Leu Asp Tyr Asp Lys Phe Gly Lys Lys Ala Glu Gly 
                965                 970                 975     


Thr Arg Thr Lys Trp Ala Leu Cys Thr Arg Gly Met Arg Ile Asp Thr 
            980                 985                 990         


Phe Arg Asn Lys Glu Lys Asn Ser  Gln Trp Asp Asn Gln  Glu Val Asp 
        995                 1000                 1005             


Leu Thr  Ala Glu Met Lys Ser  Leu Leu Glu His Tyr  Tyr Ile Asp 
    1010                 1015                 1020             


Ile His  Gly Asn Leu Lys Asp  Ala Ile Ser Ala Gln  Thr Asp Lys 
    1025                 1030                 1035             


Ala Phe  Phe Thr Gly Leu Leu  His Ile Leu Lys Leu  Thr Leu Gln 
    1040                 1045                 1050             


Met Arg  Asn Ser Ile Thr Gly  Thr Glu Thr Asp Tyr  Leu Val Ser 
    1055                 1060                 1065             


Pro Val  Ala Asp Glu Asn Gly  Ile Phe Tyr Asp Ser  Arg Ser Cys 
    1070                 1075                 1080             


Gly Asp  Glu Leu Pro Glu Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn 
    1085                 1090                 1095             


Ile Ala  Arg Lys Gly Leu Met  Met Ile Glu Gln Ile  Lys Asp Ala 
    1100                 1105                 1110             


Lys Asp  Leu Asp Asn Leu Lys  Phe Asp Ile Ser Asn  Lys Ser Trp 
    1115                 1120                 1125             


Leu Asn  Phe Ala Gln Gln Lys  Pro Tyr Lys Asn Glu  
    1130                 1135                 1140 


<210> 544
<211> 832
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 544
Met Asn Glu Ala Asp Pro Asn Asn Ala Tyr Phe Val Glu Asn Tyr Phe 
1               5                   10                  15      


Ala Thr Phe Gly Ala Val Asn Thr Pro Thr Met Gln Arg Glu Asn Leu 
            20                  25                  30          


Phe Ala Leu Val Leu Asn Ala Tyr Thr Glu Val Ala Ser Leu Leu His 
        35                  40                  45              


Ser Tyr Tyr Pro Ala Glu Lys Asn Leu Ala Gln Asp Lys Ala Asn Val 
    50                  55                  60                  


Ala Lys Ile Lys Ala Leu Leu Asp Ala Ile Lys Ser Leu Gln His Phe 
65                  70                  75                  80  


Val Lys Pro Leu Leu Gly Lys Gly Asp Glu Ser Asp Lys Asp Glu Arg 
                85                  90                  95      


Phe Tyr Gly Glu Leu Ala Ser Leu Trp Ala Glu Leu Glu Thr Val Thr 
            100                 105                 110         


Pro Leu Tyr Asn Met Ile Arg Asn Tyr Met Thr Arg Lys Pro Tyr Ser 
        115                 120                 125             


Gln Lys Lys Ile Lys Leu Asn Phe Glu Asn Pro Gln Leu Leu Gly Gly 
    130                 135                 140                 


Trp Asp Ala Asn Lys Glu Lys Asp Tyr Ala Thr Ile Ile Leu Arg Arg 
145                 150                 155                 160 


Asn Gly Leu Tyr Tyr Leu Ala Ile Met Asp Lys Asp Ser Arg Lys Leu 
                165                 170                 175     


Leu Gly Lys Ala Met Pro Ser Asp Gly Glu Cys Tyr Glu Lys Met Val 
            180                 185                 190         


Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Phe 
        195                 200                 205             


Ala Lys Ser Arg Met Glu Asp Phe Lys Pro Ser Lys Glu Leu Val Glu 
    210                 215                 220                 


Lys Tyr Asn Asn Gly Thr His Lys Lys Gly Lys Asn Phe Asn Ile Gln 
225                 230                 235                 240 


Asp Cys His Asn Leu Ile Asp Tyr Phe Lys Gln Ser Ile Ser Lys His 
                245                 250                 255     


Glu Asp Trp Gly Lys Phe Gly Phe Asn Phe Ser Asp Thr Ser Thr Tyr 
            260                 265                 270         


Glu Asp Leu Ser Gly Phe Tyr Arg Glu Val Glu Gln Gln Gly Tyr Lys 
        275                 280                 285             


Leu Ser Phe Ala Arg Val Ser Val Ser Tyr Ile Ser Gln Leu Val Glu 
    290                 295                 300                 


Glu Gly Lys Met Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu 
305                 310                 315                 320 


Tyr Ser Lys Gly Thr Pro Asn Met His Thr Leu Tyr Trp Lys Ala Leu 
                325                 330                 335     


Phe Asp Glu Arg Asn Leu Ala Asp Val Val Tyr Lys Leu Asn Gly Gln 
            340                 345                 350         


Ala Glu Met Phe Tyr Arg Lys Lys Ser Ile Glu Asn Thr His Pro Thr 
        355                 360                 365             


His Pro Ala Thr His Pro Ile Leu Asn Lys Asn Lys Asp Asn Lys Lys 
    370                 375                 380                 


Lys Glu Ser Leu Phe Glu Tyr Asp Leu Ile Lys Asp Arg Arg Tyr Thr 
385                 390                 395                 400 


Val Asp Lys Phe Met Phe His Val Pro Ile Thr Met Asn Phe Lys Ser 
                405                 410                 415     


Val Gly Ser Glu Asn Ile Asn Gln Gly Val Lys Glu Tyr Leu His His 
            420                 425                 430         


Ala Asp Asp Met His Ile Ile Gly Ile Asp Arg Gly Glu Arg His Leu 
        435                 440                 445             


Leu Tyr Leu Val Val Ile Asp Leu Gln Gly Asn Ile Lys Glu Gln Tyr 
    450                 455                 460                 


Ser Leu Asn Glu Ile Val Asn Glu Tyr Asn Gly Asn Thr Tyr His Thr 
465                 470                 475                 480 


Asn Tyr His Asp Leu Leu Asp Ala Arg Glu Asp Glu Arg Leu Lys Ala 
                485                 490                 495     


Arg Gln Ser Trp Gln Thr Ile Glu Asn Ile Lys Glu Leu Lys Glu Gly 
            500                 505                 510         


Tyr Leu Ser Gln Val Ile His Lys Ile Thr Gln Leu Met Val Lys Tyr 
        515                 520                 525             


His Ala Ile Val Val Leu Glu Asp Leu Asn Met Gly Phe Met Arg Gly 
    530                 535                 540                 


Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met Leu 
545                 550                 555                 560 


Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Lys Ala Asp Ala Ser Val 
                565                 570                 575     


Ser Gly Gly Leu Leu Asn Ala Tyr Gln Leu Thr Ser Lys Phe Asp Ser 
            580                 585                 590         


Phe Gln Lys Leu Gly Lys Gln Ser Gly Phe Leu Phe Tyr Ile Pro Ala 
        595                 600                 605             


Trp Asn Thr Ser Lys Ile Asp Pro Val Thr Gly Phe Val Asn Leu Leu 
    610                 615                 620                 


Asp Ala Arg Tyr Gln Asn Val Glu Lys Ala Lys Ala Phe Phe Ser Lys 
625                 630                 635                 640 


Phe Asp Ala Ile Arg Tyr Asn Lys Asp Lys Asp Trp Phe Glu Phe Asn 
                645                 650                 655     


Leu Asp Tyr Asp Lys Phe Gly Lys Lys Ala Glu Gly Thr Arg Thr Lys 
            660                 665                 670         


Trp Thr Leu Cys Thr Arg Gly Met Arg Ile Asp Thr Phe Arg Asn Lys 
        675                 680                 685             


Glu Lys Asn Ser Gln Trp Asp Asn Gln Glu Val Asp Leu Thr Ala Glu 
    690                 695                 700                 


Leu Lys Ser Leu Leu Glu His Tyr Tyr Ile Asp Ile His Gly Asn Leu 
705                 710                 715                 720 


Lys Glu Ala Ile Ser Thr Gln Thr Asp Lys Ala Phe Phe Thr Gly Leu 
                725                 730                 735     


Leu His Ile Leu Lys Leu Thr Leu Gln Met Arg Asn Ser Ile Thr Gly 
            740                 745                 750         


Thr Glu Thr Asp Tyr Leu Val Ser Pro Val Ala Asp Glu Asn Gly Ile 
        755                 760                 765             


Phe Tyr Asp Ser Arg Thr Cys Gly Asp Glu Leu Pro Glu Asn Ala Asp 
    770                 775                 780                 


Ala Asn Gly Ala Tyr Asn Ile Ala Arg Lys Gly Leu Met Met Ile Glu 
785                 790                 795                 800 


Gln Ile Lys Asn Ala Glu Asp Leu Gly Asn Leu Lys Phe Asp Ile Ser 
                805                 810                 815     


Asn Lys Ala Trp Leu Asn Phe Ala Gln Gln Lys Pro Tyr Lys Asn Gly 
            820                 825                 830         


<210> 545
<211> 831
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 545
Met Asp Asn Asn Asn Leu His Ala Val Asp Gly Tyr Phe Ala Thr Leu 
1               5                   10                  15      


Gly Ala Val Asn Thr Pro Thr Met Gln Arg Glu Asn Leu Phe Ala Leu 
            20                  25                  30          


Ile Gln Asn Ala Tyr Thr Asp Ile Ser Asp Leu Leu Asp Thr Pro Tyr 
        35                  40                  45              


Pro Glu Asn Lys Asn Leu Ala Gln Asp Lys Thr Asn Val Ala Lys Val 
    50                  55                  60                  


Lys Ala Leu Leu Asp Ala Ile Lys Ser Leu Gln His Phe Val Lys Pro 
65                  70                  75                  80  


Leu Leu Gly Met Gly Asp Glu Ser Asp Lys Asp Glu Arg Phe Tyr Gly 
                85                  90                  95      


Glu Leu Ala Ser Leu Trp Thr Glu Leu Asp Thr Val Thr Pro Leu Tyr 
            100                 105                 110         


Asn Met Ile Arg Asn Tyr Met Thr Arg Lys Pro Tyr Ser Glu Lys Lys 
        115                 120                 125             


Ile Lys Leu Asn Phe Glu Asn Pro Gln Leu Leu Gly Gly Trp Asp Ala 
    130                 135                 140                 


Asn Lys Glu Lys Asp Tyr Ala Thr Ile Ile Leu Arg Arg Asn Gly Met 
145                 150                 155                 160 


Tyr Tyr Leu Ala Ile Met Asp Lys Asp Ser Lys Lys Leu Leu Gly Lys 
                165                 170                 175     


Thr Met Pro Ser Asp Gly Glu Cys Tyr Glu Lys Met Val Tyr Lys Leu 
            180                 185                 190         


Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Phe Ala Lys Ser 
        195                 200                 205             


Arg Ile Asn Asp Phe Lys Pro Ser Lys Lys Ile Val Glu Asn Tyr Asn 
    210                 215                 220                 


Asn Gly Thr His Lys Lys Gly Lys Asn Phe Asn Ile Asn Asp Cys His 
225                 230                 235                 240 


Asp Leu Ile Asp Tyr Phe Lys Gln Ser Ile Asp Lys His Glu Asp Trp 
                245                 250                 255     


Ser Lys Phe Gly Phe Asn Phe Ser Asp Thr Ser Thr Tyr Glu Asp Leu 
            260                 265                 270         


Ser Gly Phe Tyr Arg Glu Val Glu Gln Gln Gly Tyr Lys Leu Ser Phe 
        275                 280                 285             


Thr Asn Ile Ser Val Ser Phe Ile Asp Lys Leu Val Asp Glu Gly Lys 
    290                 295                 300                 


Met Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Tyr Ser Lys 
305                 310                 315                 320 


Gly Thr Pro Asn Met His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu 
                325                 330                 335     


Arg Asn Leu Ala Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Met 
            340                 345                 350         


Phe Tyr Arg Lys Lys Ser Ile Asn Asn Thr His Pro Thr His His Ala 
        355                 360                 365             


Asn His Pro Ile Gln Asn Lys Asn Lys Asp Asn Lys Lys Lys Glu Ser 
    370                 375                 380                 


Val Phe Glu Tyr Asp Leu Val Lys Asp Arg Arg Tyr Thr Glu Asp Lys 
385                 390                 395                 400 


Phe Leu Phe His Val Pro Ile Thr Met Asn Phe Asn Ser Val Gly Ala 
                405                 410                 415     


Glu Asn Ile Asn Gln Gln Val Arg Lys Tyr Leu Gln Gln Ala Asp Asp 
            420                 425                 430         


Thr His Ile Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu 
        435                 440                 445             


Val Val Ile Asp Met Gln Gly Asn Ile Lys Glu Gln Phe Ser Leu Asn 
    450                 455                 460                 


Glu Ile Val Asn Glu Tyr Asn Gly Asn Thr Tyr Arg Thr Asn Tyr His 
465                 470                 475                 480 


Asp Leu Leu Asp Val Arg Ala Asp Lys Arg Leu Lys Ala Ser Gln Ser 
                485                 490                 495     


Trp Gln Thr Ile Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Leu Ser 
            500                 505                 510         


Gln Ala Ile His Lys Ile Thr Gln Leu Met Val Lys Tyr His Ala Val 
        515                 520                 525             


Val Val Leu Glu Asp Leu Asn Lys Gly Phe Met Arg Gly Arg Gln Lys 
    530                 535                 540                 


Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys 
545                 550                 555                 560 


Leu Asn Tyr Leu Val Asp Lys His Lys Asp Ala Asn Glu Thr Gly Gly 
                565                 570                 575     


Leu Leu His Ala Leu Gln Leu Thr Ser Glu Phe Lys Asn Phe Lys Lys 
            580                 585                 590         


Ser Glu Tyr Gln Asn Gly Phe Leu Phe Tyr Ile Pro Ala Trp Asn Thr 
        595                 600                 605             


Ser Lys Ile Asp Pro Val Thr Gly Phe Val Asn Arg Phe Asp Thr Arg 
    610                 615                 620                 


Tyr Thr Asn Ala Val Glu Ala Gln Lys Phe Phe Arg Lys Phe Asp Glu 
625                 630                 635                 640 


Ile Arg Tyr Asn Glu Glu Lys Asp Trp Phe Glu Phe Glu Phe Asp Tyr 
                645                 650                 655     


Asp Lys Phe Thr Gln Lys Ala His Gly Thr Arg Thr Arg Trp Thr Leu 
            660                 665                 670         


Cys Thr His Gly Lys Arg Leu Arg Ser Phe Arg Asn Pro Ala Lys Gln 
        675                 680                 685             


Tyr Asn Trp Asp Ser Glu Val Val Ala Leu Thr Asp Glu Phe Lys Arg 
    690                 695                 700                 


Ile Leu Gly Glu Ala Gly Ile Asp Ile His Glu Asn Leu Lys Asp Ala 
705                 710                 715                 720 


Ile Ser Asn Leu Glu Gly Lys Arg Arg Lys Tyr Leu Glu Pro Leu Met 
                725                 730                 735     


Gln Phe Met Lys Leu Leu Leu Gln Leu Arg Asn Ser Arg Lys Asn Pro 
            740                 745                 750         


Glu Glu Asp Tyr Ile Leu Ser Pro Val Ala Asp Glu Asn Gly Val Phe 
        755                 760                 765             


Tyr Asp Ser Arg Ser Cys Gly Asp Lys Leu Pro Glu Asn Ala Asp Ala 
    770                 775                 780                 


Asn Gly Ala Tyr Asn Ile Ala Arg Lys Gly Leu Met Leu Ile Arg Gln 
785                 790                 795                 800 


Ile Lys Glu Ala Lys Glu Leu Gly Lys Val Lys Tyr Asp Ile Ser Asn 
                805                 810                 815     


Lys Ala Trp Leu Asn Phe Ala Gln Gln Lys Pro Tyr Lys Asn Glu 
            820                 825                 830     


<210> 546
<211> 1177
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 546
Met Gln Lys Lys Ala Phe Glu Glu Asn Gln Gln Asn Leu Arg Ser Ile 
1               5                   10                  15      


Ile Ala Lys Lys Leu Thr Glu Asp Lys Ala Tyr Ala Asn Leu Phe Gly 
            20                  25                  30          


Lys Asn Leu Leu Glu Ser Tyr Lys Asp Lys Thr Asp Lys Thr Lys Ile 
        35                  40                  45              


Ile Asp Ser Asp Leu Ile Lys Phe Ile Asn Thr Ala Glu Ser Thr Gln 
    50                  55                  60                  


Leu Asp Ser Met Ser Gln Asp Glu Ala Lys Glu Ile Val Lys Glu Phe 
65                  70                  75                  80  


Trp Gly Phe Thr Thr Tyr Phe Val Gly Phe Phe Asp Asn Arg Lys Asn 
                85                  90                  95      


Met Tyr Thr Ala Glu Glu Lys Ser Thr Gly Ile Ala Tyr Arg Leu Ile 
            100                 105                 110         


Asn Glu Asn Leu Pro Lys Phe Ile Asp Asn Met Glu Ala Phe Lys Lys 
        115                 120                 125             


Ala Ile Ala Arg Pro Glu Ile Gln Ala Asp Met Glu Glu Leu Tyr Ser 
    130                 135                 140                 


Asn Phe Ser Glu Tyr Leu Asn Val Glu Ser Ile Gln Glu Met Phe Leu 
145                 150                 155                 160 


Leu Asp Tyr Tyr Asn Met Leu Leu Thr Gln Lys Gln Ile Asp Val Tyr 
                165                 170                 175     


Asn Ala Ile Ile Gly Gly Lys Thr Asp Asp Glu His Asp Val Lys Ile 
            180                 185                 190         


Lys Gly Ile Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Gln His Lys Asp 
        195                 200                 205             


Asp Lys Leu Pro Lys Leu Lys Ala Leu Phe Lys Gln Ile Leu Ser Asp 
    210                 215                 220                 


Arg Asn Ala Ile Ser Trp Leu Pro Glu Glu Phe Asn Ser Asp Gln Glu 
225                 230                 235                 240 


Val Leu Asn Ala Ile Lys Asp Cys Tyr Glu Arg Leu Ser Glu Asn Val 
                245                 250                 255     


Leu Gly Asp Lys Val Leu Lys Ser Met Leu Gly Ser Leu Ala Asp Tyr 
            260                 265                 270         


Ser Leu Asp Gly Ile Phe Ile Arg Asn Asp Leu Gln Leu Thr Asp Ile 
        275                 280                 285             


Ser Gln Lys Met Phe Gly Asn Trp Ser Val Ile Gln Asn Ala Ile Met 
    290                 295                 300                 


Gln Asn Ile Lys His Val Ala Pro Ala Arg Lys His Lys Glu Ser Glu 
305                 310                 315                 320 


Glu Glu Tyr Glu Asn Arg Ile Ala Gly Ile Phe Lys Lys Ala Asp Ser 
                325                 330                 335     


Phe Ser Ile Ser Tyr Ile Asp Ala Cys Leu Asn Glu Thr Asp Pro Asn 
            340                 345                 350         


Asn Ala Tyr Phe Val Glu Asn Tyr Phe Ala Thr Leu Gly Ala Val Asp 
        355                 360                 365             


Thr Pro Thr Met Gln Arg Glu Asn Leu Phe Ala Leu Val Gln Asn Ala 
    370                 375                 380                 


Tyr Thr Glu Ile Thr Ala Leu Leu His Ser Asp Tyr Pro Thr Glu Lys 
385                 390                 395                 400 


Asn Leu Ala Gln Asp Lys Ala Asn Val Ala Lys Ile Lys Ala Leu Leu 
                405                 410                 415     


Asp Ala Ile Lys Ser Leu Gln His Phe Val Lys Pro Leu Leu Gly Lys 
            420                 425                 430         


Gly Asp Glu Ser Asp Lys Asp Glu Arg Phe Tyr Gly Glu Leu Ala Ser 
        435                 440                 445             


Leu Trp Ala Glu Leu Asp Thr Met Thr Pro Leu Tyr Asn Met Ile Arg 
    450                 455                 460                 


Asn Tyr Met Thr Arg Lys Pro Tyr Ser Gln Lys Lys Ile Lys Leu Asn 
465                 470                 475                 480 


Phe Glu Asn Pro Gln Leu Leu Gly Gly Trp Asp Ala Asn Lys Glu Lys 
                485                 490                 495     


Asp Tyr Ala Thr Ile Ile Leu Arg Arg Asn Gly Leu Tyr Tyr Leu Ala 
            500                 505                 510         


Ile Met Asn Lys Asp Ser Lys Lys Leu Leu Gly Lys Ala Met Pro Ser 
        515                 520                 525             


Asp Gly Glu Cys Tyr Glu Lys Met Val Tyr Lys Leu Leu Pro Gly Ala 
    530                 535                 540                 


Asn Lys Met Leu Pro Lys Val Phe Phe Ala Lys Ser Arg Met Glu Asp 
545                 550                 555                 560 


Phe Lys Pro Ser Lys Glu Leu Val Glu Lys Tyr Asn Asn Gly Thr His 
                565                 570                 575     


Lys Lys Gly Lys Asn Phe Asn Ile Gln Asp Cys His Asn Leu Ile Asp 
            580                 585                 590         


Tyr Phe Lys Gln Ser Ile Asp Lys His Glu Asp Trp Ser Lys Phe Gly 
        595                 600                 605             


Phe Lys Phe Ser Asp Thr Ser Thr Tyr Glu Asp Leu Ser Gly Phe Tyr 
    610                 615                 620                 


Arg Glu Val Glu Gln Gln Gly Tyr Lys Leu Ser Phe Ala Arg Val Ser 
625                 630                 635                 640 


Val Ser Tyr Ile Asn Gln Leu Val Glu Glu Gly Lys Met Tyr Leu Phe 
                645                 650                 655     


Gln Ile Tyr Asn Lys Asp Phe Ser Glu Tyr Ser Lys Gly Thr Pro Asn 
            660                 665                 670         


Met His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn Leu Ala 
        675                 680                 685             


Asp Val Val Tyr Lys Leu Asn Gly Gln Ala Glu Met Phe Tyr Arg Lys 
    690                 695                 700                 


Lys Ser Ile Glu Asn Thr His Pro Thr His Pro Ala Asn His Pro Ile 
705                 710                 715                 720 


Leu Asn Lys Asn Lys Asp Asn Lys Lys Lys Glu Ser Leu Phe Glu Tyr 
                725                 730                 735     


Asp Leu Ile Lys Asp Arg Arg Tyr Thr Val Asp Lys Phe Met Phe His 
            740                 745                 750         


Val Pro Ile Thr Met Asn Phe Lys Ser Val Gly Ser Glu Asn Ile Asn 
        755                 760                 765             


Gln Asp Val Lys Ala Tyr Leu Arg His Ala Asp Asp Met His Ile Ile 
    770                 775                 780                 


Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Val Val Ile Asp 
785                 790                 795                 800 


Leu Gln Gly Asn Ile Lys Glu Gln Phe Ser Leu Asn Glu Ile Val Asn 
                805                 810                 815     


Asp Tyr Asn Gly Asn Thr Tyr His Thr Asn Tyr His Asp Leu Leu Asp 
            820                 825                 830         


Val Arg Glu Asp Glu Arg Leu Lys Ala Arg Gln Ser Trp Gln Thr Ile 
        835                 840                 845             


Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Leu Ser Gln Val Ile His 
    850                 855                 860                 


Lys Ile Thr Gln Leu Met Val Lys Tyr His Ala Ile Val Val Leu Glu 
865                 870                 875                 880 


Asp Leu Asn Met Gly Phe Met Arg Gly Arg Gln Lys Val Glu Lys Gln 
                885                 890                 895     


Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Glu Lys Leu Asn Tyr Leu 
            900                 905                 910         


Val Asp Lys Lys Ala Asp Ala Ser Val Ser Gly Gly Leu Leu Asn Ala 
        915                 920                 925             


Tyr Gln Leu Thr Ser Lys Phe Asp Ser Phe Gln Lys Leu Arg Lys Gln 
    930                 935                 940                 


Ser Gly Phe Leu Phe Tyr Ile Pro Ala Trp Asn Thr Ser Lys Ile Asp 
945                 950                 955                 960 


Pro Ile Thr Gly Phe Val Asn Leu Leu Asp Thr Arg Tyr Gln Asn Val 
                965                 970                 975     


Glu Lys Ala Lys Ala Phe Phe Ser Lys Phe Asp Ala Ile Arg Tyr Asn 
            980                 985                 990         


Lys Asp Lys Glu Trp Phe Glu Phe  Asp Leu Asp Tyr Asp  Lys Phe Gly 
        995                 1000                 1005             


Arg Lys  Ala Glu Gly Thr Arg  Thr Lys Trp Thr Leu  Cys Thr Arg 
    1010                 1015                 1020             


Gly Met  Arg Ile Asp Thr Phe  Arg Asn Lys Glu Lys  Asn Ser Gln 
    1025                 1030                 1035             


Trp Asp  Asn Gln Glu Ile Asp  Leu Thr Ala Glu Met  Lys Ser Leu 
    1040                 1045                 1050             


Leu Glu  His Tyr Tyr Ile Asp  Ile Gln Gly Asn Leu  Lys Glu Ala 
    1055                 1060                 1065             


Ile Cys  Thr Gln Thr Asp Lys  Ala Phe Phe Thr Gly  Leu Leu His 
    1070                 1075                 1080             


Ile Leu  Lys Leu Thr Leu Gln  Met Arg Asn Ser Ile  Thr Gly Thr 
    1085                 1090                 1095             


Gln Thr  Asp Tyr Leu Val Ser  Pro Val Ala Asp Glu  Asn Gly Ile 
    1100                 1105                 1110             


Phe Tyr  Asp Ser Arg Ser Cys  Gly Asp Ser Leu Pro  Glu Asn Ala 
    1115                 1120                 1125             


Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Arg Lys Gly  Leu Met Leu 
    1130                 1135                 1140             


Ile Glu  Lys Ile Lys Asn Ala  Glu Asp Leu Asp Thr  Ile Lys Phe 
    1145                 1150                 1155             


Asp Ile  Ser Asn Lys Ala Trp  Leu Asn Phe Ala Gln  Gln Lys Pro 
    1160                 1165                 1170             


Tyr Lys  Asn Gly 
    1175         


<210> 547
<211> 814
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 547
Met Leu Glu Asn Glu Gln Glu Ala Glu Lys Ile Lys Asn Lys Leu Asp 
1               5                   10                  15      


Asp Ile Met Asn Ile Tyr His Trp Ile Lys Ile Phe Leu Val Asp Glu 
            20                  25                  30          


Glu Ile Glu Lys Asp Met Asp Phe Tyr Ser Glu Ile Glu Asp Ile Tyr 
        35                  40                  45              


Glu Glu Leu Ser Pro Leu Val Ser Leu Tyr Asn Arg Val Arg Asn Tyr 
    50                  55                  60                  


Val Thr Gln Lys Pro Tyr Ser Gln Glu Lys Met Lys Leu Asn Phe Gly 
65                  70                  75                  80  


Ser Pro Thr Leu Ala Asp Gly Trp Ser Lys Ser Lys Glu Phe Ser Asn 
                85                  90                  95      


Asn Ala Ile Ile Met Leu Lys Asp Gly Lys Tyr Tyr Ile Gly Ile Phe 
            100                 105                 110         


Asn Ile Arg Asn Lys Pro Asn Lys Glu Val Ile Glu Gly Arg Asn Asn 
        115                 120                 125             


Arg Ile Asn Asp Ser Asp Tyr Lys Lys Met Val Tyr Arg Leu Leu Pro 
    130                 135                 140                 


Gly Ala Asn Lys Met Leu Pro Lys Val Met Phe Ser Lys Lys Gly Ile 
145                 150                 155                 160 


Glu Tyr Tyr Asn Pro Ser Gln Tyr Ile Leu Ser Gly Tyr Asn Ser Lys 
                165                 170                 175     


Lys His Ile Lys Ser Asn Glu Asn Phe Asp Ile Asn Phe Cys His Asp 
            180                 185                 190         


Leu Ile Asp Phe Phe Lys Glu Ser Ile Asn Lys Asn Glu Glu Trp Lys 
        195                 200                 205             


Asn Phe Asp Phe Lys Phe Ser Asp Thr Glu Ser Tyr Asn Asp Ile Ser 
    210                 215                 220                 


Glu Phe Tyr Arg Glu Val Glu Gln Gln Gly Tyr Lys Ile Glu Trp Val 
225                 230                 235                 240 


Tyr Ile Ser Glu Gln Asp Ile Glu Gln Leu Glu Lys Asn Gly Gln Leu 
                245                 250                 255     


Tyr Ile Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys Lys Ser Ile Gly 
            260                 265                 270         


Asn Lys Asn Leu His Thr Met Tyr Leu Glu Asn Leu Phe Ser Glu Glu 
        275                 280                 285             


Asn Leu Lys Asp Val Val Leu Lys Leu Asn Gly Glu Ala Glu Ile Phe 
    290                 295                 300                 


Phe Arg Lys Ser Ser Ile Lys Lys Pro Ile Val His Lys Ala Gly Ser 
305                 310                 315                 320 


Ile Leu Val Asn Lys Cys Ile Glu Asp Glu Thr Gly Asn Lys Val Ser 
                325                 330                 335     


Phe Pro Asp Asp Ile Tyr Asn Glu Ile Tyr Gln Tyr Met Asn Gly Met 
            340                 345                 350         


Thr Asp Val Leu Ser Glu Arg Ala Gln Asn Tyr Tyr Glu Lys Val Lys 
        355                 360                 365             


His Ser Val Ser Lys Gln Asp Ile Val Lys Asp Tyr Arg Tyr Thr Val 
    370                 375                 380                 


Asp Lys Tyr Phe Ile His Leu Pro Ile Thr Ile Asn Phe Lys Ala Ser 
385                 390                 395                 400 


Ser Phe Met Pro Ile Asn Asp Ile Ala Leu Lys Tyr Ile Ala Lys Arg 
                405                 410                 415     


Asp Asp Ile His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile 
            420                 425                 430         


Tyr Val Ser Val Ile Asp Leu Gln Gly Asn Ile Val Tyr Gln Lys Asn 
        435                 440                 445             


Tyr Asn Val Val Asn Gly Tyr Asp Tyr Lys Ala Lys Leu Arg Glu Thr 
    450                 455                 460                 


Glu Ile Gln Arg Asp Asn Ala Arg Lys Asn Trp Lys Glu Ile Gly Lys 
465                 470                 475                 480 


Ile Lys Gln Leu Lys Glu Gly Tyr Leu Ser Leu Val Val His Glu Ile 
                485                 490                 495     


Ala Gln Leu Ile Val Lys Tyr Asn Ala Ile Val Val Met Glu Asp Leu 
            500                 505                 510         


Asn Met Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Arg Gln Val Tyr 
        515                 520                 525             


Gln Lys Phe Glu Asn Met Leu Ile Asn Lys Leu Asn Tyr Leu Val Asp 
    530                 535                 540                 


Lys Asn Lys Lys Val Asp Glu Asp Gly Gly Leu Leu Arg Gly Tyr Gln 
545                 550                 555                 560 


Leu Thr Tyr Val Pro Gly Gln Lys Glu His Val Gly Lys Gln Cys Gly 
                565                 570                 575     


Phe Ile Phe Tyr Val Pro Ala Ala Tyr Thr Ser Lys Ile Asp Pro Thr 
            580                 585                 590         


Thr Gly Phe Val Ser Ile Phe Asn Asn Lys Val Asn Ala Lys Glu Phe 
        595                 600                 605             


Val Thr Lys Phe Asp Ser Ile Lys Tyr Asn Lys Asn Met Lys Met Phe 
    610                 615                 620                 


Glu Leu Lys Phe Asp Tyr Asn Asn Phe Glu Thr Tyr Asn Ile Thr Leu 
625                 630                 635                 640 


Ala Lys Ser Lys Trp Thr Ile Tyr Thr Asn Gly Ile Arg Leu Lys Arg 
                645                 650                 655     


Glu Tyr Asn Asn Gly Arg Trp Asn Lys Ile Thr Glu Val Asp Leu Thr 
            660                 665                 670         


Lys Glu Met Ala Asn Thr Leu Lys Lys Tyr Asp Ile Glu Phe Glu Asn 
        675                 680                 685             


Asn Glu Glu Ile Leu Lys Ser Ile Ser Gln Leu Asp Glu Lys Asn Gln 
    690                 695                 700                 


Arg Asn Ile Cys Asn Glu Ile Lys Glu Ile Ile Lys Leu Ile Val Gln 
705                 710                 715                 720 


Leu Arg Asn Ser Met Pro Asp Asn Gly Ser Lys Asp Asn Glu Tyr Asp 
                725                 730                 735     


Lys Ile Ile Ser Pro Val Leu Asn Glu Asn Asn Tyr Phe Tyr Asp Ser 
            740                 745                 750         


Ser Glu Val Cys Asp Asn Ser Ala Pro Glu Asn Ala Asp Ala Asn Gly 
        755                 760                 765             


Ala Tyr Cys Ile Ala Met Lys Gly Leu Tyr Gln Val Ile Gln Ile Lys 
    770                 775                 780                 


Glu Asn Trp Ser Gln Asp Ser Asn Pro Lys Asn Ile Leu Gly Ile Lys 
785                 790                 795                 800 


His Tyr Glu Trp Phe Asp Phe Met Gln Asn Lys Arg Tyr Leu 
                805                 810                 


<210> 548
<211> 1262
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 548
Met Ala Lys Asn Thr Ile Phe Thr Gln Phe Thr Gly Leu Tyr Pro Val 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Met Gly Lys Thr Leu Glu 
            20                  25                  30          


Lys Ile Lys Glu Thr Gly Val Ile Glu Asn Asp Lys Lys Arg His Asn 
        35                  40                  45              


Asp Tyr Phe Asp Ala Lys Lys Ile Ile Asp Lys Tyr His Lys Tyr Phe 
    50                  55                  60                  


Ile Asp Ala Ala Leu Ser Lys Phe Ser Arg Ile Asp Trp Asn Pro Leu 
65                  70                  75                  80  


Lys Glu Ala Ile Glu Gly Ser Leu Asp Arg Ser Asp Ala Ser Lys Lys 
                85                  90                  95      


Lys Leu Glu Lys Thr Gln Thr Glu Phe Arg Lys Lys Ile Ala Lys Ala 
            100                 105                 110         


Leu Thr Thr His Asp His Tyr Lys Glu Leu Thr Ala Ser Thr Pro Lys 
        115                 120                 125             


Asp Leu Phe Leu Lys Val Phe Pro Asp His Phe Gly Lys Gln Pro Ala 
    130                 135                 140                 


Ile Asp Thr Phe Asp Gly Phe Ser Ser Tyr Phe Thr Gly Phe Gln Glu 
145                 150                 155                 160 


Asn Arg Gln Asn Ile Tyr Ser Asp Glu Ala Ile Ser Thr Ala Ile Pro 
                165                 170                 175     


Tyr Arg Leu Val His Asp Asn Phe Pro Lys Phe Leu Ser Asn Ile Glu 
            180                 185                 190         


Val Tyr Lys Thr Leu Lys Asp Asn Ala Pro Ser Val Leu Ser Asp Ala 
        195                 200                 205             


Glu Asn Glu Leu Lys Asp Phe Leu Asn Gly Lys Pro Leu Ala Asn Ile 
    210                 215                 220                 


Phe Glu Leu Asn Ala Tyr Asn Asp Val Leu Thr Gln Ser Gly Ile Asp 
225                 230                 235                 240 


Phe Phe Asn Gln Val Ile Gly Gly Ile Ser Gly Glu Gly Gly Glu Lys 
                245                 250                 255     


Lys Thr Arg Gly Ile Asn Glu Phe Ser Asn Leu Tyr Arg Gln Gln His 
            260                 265                 270         


Pro Glu Phe Ala Gln Lys Arg Leu Ala Thr Lys Met Ile Pro Leu Tyr 
        275                 280                 285             


Lys Gln Ile Leu Ser Asp Arg Glu Thr Lys Ser Phe Ile Leu Glu Ser 
    290                 295                 300                 


Tyr Ser Thr Asp Ser Gln Val Gln Glu Ser Val Lys Glu Phe Phe Glu 
305                 310                 315                 320 


Ser Gln Ile Leu Asn Cys Asp Ile Ala Gly Arg Lys Val Asn Val Leu 
                325                 330                 335     


Asn Glu Leu Thr Ser Leu Ile Lys Arg Ile Ala Glu Phe Asp Leu Gly 
            340                 345                 350         


Ser Ile Tyr Ile Asn Gln Glu Glu Leu Ser Asn Ile Ser Leu Glu Leu 
        355                 360                 365             


Phe Lys Ser Trp Asn Thr Ile Asn Ala Val Leu Phe Lys Asn Ala Glu 
    370                 375                 380                 


Asn Arg Ile Gly Ser Ala Glu Lys Ala Ala Asn Lys Lys Lys Ile Asp 
385                 390                 395                 400 


Ala Trp Met Lys Ser Asn Glu Phe Ser Ile Ala Thr Leu Asn Leu Ala 
                405                 410                 415     


Ile Ala Glu Ser Asp Ser Glu Glu Ile Ser Arg Val Lys Ile Glu Ser 
            420                 425                 430         


Tyr Trp Asn Asp Phe Glu Ala Lys Val Gln Ser Ile Leu Cys Gly Asp 
        435                 440                 445             


Asn Arg Arg Asn Leu Asp Glu Phe Leu Ser Ala Thr Phe Asn Glu Asn 
    450                 455                 460                 


Asn Ala Leu Arg Glu Asp Ser Glu Ile Ile Gly Lys Leu Lys Ala Phe 
465                 470                 475                 480 


Leu Asp Ala Leu Ile Glu Ile Met His Ser Ile Lys Pro Leu Ile Ser 
                485                 490                 495     


Asp Ala Glu Asn Arg Asp Leu Ser Phe Tyr Asn Glu Leu Met Pro Leu 
            500                 505                 510         


Tyr Asp Gln Leu Ser Leu Val Val Pro Leu Tyr Asn Lys Ile Arg Asn 
        515                 520                 525             


Tyr Ala Thr Gln Lys Leu Thr Glu Ser Glu Lys Phe Lys Leu Asn Phe 
    530                 535                 540                 


Asp Asn Pro Thr Leu Ala Asp Gly Trp Asp Gln Asn Lys Glu Asp Ala 
545                 550                 555                 560 


Asn Thr Ala Ile Leu Leu Leu Lys Asn Gly Leu Tyr Tyr Leu Gly Ile 
                565                 570                 575     


Met Asn Ala Lys Asn Lys Pro Lys Ile Lys Asp Phe Lys Thr Ser Glu 
            580                 585                 590         


Ser Glu Asp Cys Tyr Asp Lys Met Val Tyr Lys Leu Leu Pro Gly Pro 
        595                 600                 605             


Asn Lys Met Leu Pro Lys Val Phe Phe Ser Glu Lys Gly Leu Ala Thr 
    610                 615                 620                 


Phe Lys Pro Pro Lys Asp Ile Leu Asp Gly Tyr Asn Ala Gly Lys His 
625                 630                 635                 640 


Lys Lys Gly Asp Leu Phe Asp Ile Gly Phe Cys His Gln Leu Ile Asp 
                645                 650                 655     


Phe Phe Lys Glu Ser Ile Ala Lys His Pro Asp Trp Lys Lys Phe Asp 
            660                 665                 670         


Phe Lys Phe Ser Asp Thr Ser Ser Tyr Glu Asp Ile Ser Gly Phe Tyr 
        675                 680                 685             


Lys Glu Val Thr Asp Gln Gly Tyr Lys Ile Thr Phe Ser Lys Ile Pro 
    690                 695                 700                 


Thr Ser Gln Ile Asp Glu Trp Val Asn Glu Gly Lys Leu Phe Leu Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ala Pro Gly Ala Lys Gly Ser Pro Asn 
                725                 730                 735     


Leu His Thr Leu Tyr Trp Lys Ser Val Phe Ser Pro Glu Asn Leu Lys 
            740                 745                 750         


Asp Val Val Val Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr Arg Pro 
        755                 760                 765             


Ser Ser Val Lys Lys Pro Tyr Ser His Lys Val Gly Glu Lys Leu Val 
    770                 775                 780                 


Asn Arg Ile Gly Lys Asp Gly Leu Pro Leu Pro Glu Ser Val Phe Gly 
785                 790                 795                 800 


Glu Leu Phe Arg Tyr Phe Asn Gly Lys Leu Asp Gly Glu Leu Ser Asp 
                805                 810                 815     


Glu Ala Lys Arg Tyr Leu Asp Val Ala Val Val Lys Asp Val Lys His 
            820                 825                 830         


Glu Ile Val Lys Asp Arg Arg Tyr Thr Gln Asp Lys Phe Glu Phe His 
        835                 840                 845             


Val Pro Leu Thr Leu Asn Phe Lys Ala Asp Ser Lys Asn Glu Tyr Met 
    850                 855                 860                 


Asn Glu Arg Val Arg His Phe Leu Lys Asp Asn Pro Asp Val Asn Ile 
865                 870                 875                 880 


Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Met Thr Leu Ile 
                885                 890                 895     


Asn Gln Lys Gly Glu Ile Leu Lys Gln Lys Ser Phe Asn Ile Val Glu 
            900                 905                 910         


Ser Val Asn Tyr Gln Ala Lys Leu Val Gln Arg Glu Lys Glu Arg Asp 
        915                 920                 925             


Ala Ala Arg Lys Ser Trp Ser Ser Val Gly Lys Ile Lys Asp Leu Lys 
    930                 935                 940                 


Glu Gly Phe Leu Ser Gln Val Ile His Glu Ile Thr Thr Thr Met Ile 
945                 950                 955                 960 


Glu Asn Asn Ala Ile Val Val Leu Glu Asp Leu Asn Phe Gly Phe Lys 
                965                 970                 975     


Arg Gly Arg Phe Cys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys 
            980                 985                 990         


Met Leu Ile Asp Lys Leu Asn Tyr  Leu Val Phe Lys Asn  Lys Pro Glu 
        995                 1000                 1005             


Gly Asp  Val Gly Gly Val Leu  Lys Gly Tyr Gln Leu  Ala Glu Lys 
    1010                 1015                 1020             


Phe Asp  Ser Phe Gln Lys Leu  Gly Lys Gln Ser Gly  Phe Leu Phe 
    1025                 1030                 1035             


Tyr Ile  Pro Ala Ala Tyr Thr  Ser Lys Ile Asp Pro  Thr Thr Gly 
    1040                 1045                 1050             


Phe Ala  Asn Leu Phe Asn Met  Thr Glu Leu Thr Ser  Ala Glu Lys 
    1055                 1060                 1065             


Lys Lys  Asp Phe Leu Ser His  Phe Asp Asp Ile Thr  Tyr Asp Gly 
    1070                 1075                 1080             


Lys Asn  Asp Arg Phe Leu Phe  Gly Phe Asp Tyr Lys  Asn Phe Lys 
    1085                 1090                 1095             


Cys Phe  Gln Thr Asp Phe Ile  Lys Lys Trp Thr Val  Tyr Thr Gln 
    1100                 1105                 1110             


Gly Lys  Arg Ile Val Tyr Asp  Lys Glu Ser Lys Ser  Ala Lys Glu 
    1115                 1120                 1125             


Ile Phe  Pro Val Glu Ile Ile  Lys Ala Ala Leu Ala  Lys Gln Asn 
    1130                 1135                 1140             


Ile Ala  Leu Thr Asp Gln Leu  Asp Val Leu Ser Ala  Ile Asn Ser 
    1145                 1150                 1155             


Val Glu  Ala Ser Pro Lys Ser  Ala Ser Phe Phe Gly  Asn Ile Cys 
    1160                 1165                 1170             


Tyr Ala  Phe Glu Lys Thr Leu  Gln Met Arg Asn Ser  Ile Pro Asn 
    1175                 1180                 1185             


Thr Asp  Glu Asp Tyr Leu Val  Ser Pro Val Met Asn  Lys Arg Gly 
    1190                 1195                 1200             


Glu Phe  Tyr Asp Ser Arg Ser  Cys Asp Asp Ala Leu  Pro Gln Asn 
    1205                 1210                 1215             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Tyr 
    1220                 1225                 1230             


Leu Ile  Lys Asn Val Phe Asp  Ala Gly Gly Lys Asp  Leu Lys Ile 
    1235                 1240                 1245             


Ser His  Glu Asp Trp Phe Lys  Phe Ala Gln Ser Arg  Asn Cys 
    1250                 1255                 1260         


<210> 549
<211> 791
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 549
Met Arg Pro Val Leu Gln Leu Thr Asp Thr Glu Asp Lys Leu Ser Gln 
1               5                   10                  15      


Asn Lys Pro Ala Val Gly Lys Ile Lys Ala Leu Leu Asp Ala Phe Lys 
            20                  25                  30          


Asp Leu Gln His Phe Ile Lys Pro Leu Leu Gly Ser Gly Glu Glu Asn 
        35                  40                  45              


Glu Lys Asp Glu Leu Phe Tyr Gly Ala Phe Gln Leu Ile Trp Asp Glu 
    50                  55                  60                  


Leu Asp Thr Val Thr Pro Leu Tyr Asn Lys Val Arg Asn Trp Leu Thr 
65                  70                  75                  80  


Arg Lys Pro Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Asp Asn Ala 
                85                  90                  95      


Gln Leu Leu Gly Gly Trp Asp Val Asn Lys Glu Pro Asp Cys Thr Gly 
            100                 105                 110         


Val Leu Leu Arg Lys Asp Gly Phe Tyr Tyr Leu Gly Ile Met Asn Lys 
        115                 120                 125             


Lys Ser Asn Arg Ile Phe Asp Ala Asp Val Thr Pro Ala Asp Gly Ile 
    130                 135                 140                 


Cys Tyr Glu Lys Ile Asp Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met 
145                 150                 155                 160 


Leu Pro Lys Val Phe Phe Ser Lys Ser Arg Ile Asp Glu Phe Ala Pro 
                165                 170                 175     


Ser Glu Ala Ile Leu Ser Ser Tyr Lys Arg Gly Thr His Lys Lys Gly 
            180                 185                 190         


Ala Asp Phe Ser Leu Ser Asp Cys His Arg Leu Ile Asp Phe Phe Lys 
        195                 200                 205             


Ala Ser Ile Asn Lys His Glu Asp Trp Ser Lys Phe Gly Phe Gln Phe 
    210                 215                 220                 


Ser Asp Thr Lys Thr Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu Val 
225                 230                 235                 240 


Glu Gln Gln Gly Tyr Met Leu Ser Ser His Gln Val Ser Glu Ala Tyr 
                245                 250                 255     


Ile Asn Gln Met Val Glu Glu Gly Lys Leu Phe Leu Phe Arg Ile Trp 
            260                 265                 270         


Asn Lys Asp Phe Ser Glu Tyr Ser Lys Gly Thr Pro Asn Met His Thr 
        275                 280                 285             


Leu Tyr Trp Arg Met Leu Phe Asp Glu Arg Asn Leu Ala Asp Val Val 
    290                 295                 300                 


Tyr Lys Leu Asn Gly Gln Ala Glu Val Phe Tyr Arg Lys Ala Ser Ile 
305                 310                 315                 320 


Lys Ala Glu Asn Gln Ile Met His Pro Ala His His Pro Ile Glu Asn 
                325                 330                 335     


Lys Asn Thr Leu Asn Glu Lys Arg Ser Ser Thr Phe Asp Tyr Asp Leu 
            340                 345                 350         


Val Lys Asp Arg Arg Tyr Thr Val Asp Lys Phe Gln Phe His Val Pro 
        355                 360                 365             


Ile Thr Ile Asn Phe Lys Ala Ile Gly Gln Thr Asn Val Asn Pro Ile 
    370                 375                 380                 


Val His Glu Thr Ile Arg Arg Gly Gly Phe Thr His Val Ile Gly Ile 
385                 390                 395                 400 


Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Ser Leu Ile Asp Leu Lys 
                405                 410                 415     


Gly His Ile Val Lys Gln Met Thr Leu Asn Glu Ile Ile Asn Glu Tyr 
            420                 425                 430         


Asn Gly Leu Ala His Lys Thr Asn Tyr Tyr Asp Leu Leu Val Lys Arg 
        435                 440                 445             


Glu Gly Glu Arg Thr Thr Ala Arg Arg Ser Trp Asp Thr Ile Glu Asn 
    450                 455                 460                 


Ile Lys Glu Leu Lys Glu Gly Tyr Leu Ser Gln Val Ile His Ile Ile 
465                 470                 475                 480 


Ser Lys Met Met Val Glu Tyr Asn Ala Ile Val Val Leu Glu Asp Leu 
                485                 490                 495     


Asn Met Gly Phe Met Arg Gly Arg Gln Lys Ile Glu Arg Gln Val Tyr 
            500                 505                 510         


Glu Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Cys Tyr Ile Asp 
        515                 520                 525             


Lys Gln Ala Asp Ser Gln Ser Glu Gly Gly Leu Leu His Pro Ile Gln 
    530                 535                 540                 


Leu Ala Asn Lys Phe Glu Ser Phe Arg Lys Leu Gly Lys Gln Ser Gly 
545                 550                 555                 560 


Cys Leu Phe Tyr Ile Pro Ala Trp Asn Thr Ser Lys Ile Asp Pro Val 
                565                 570                 575     


Thr Gly Phe Val Asn Leu Phe Asp Thr Arg Tyr Glu Thr Arg Glu Lys 
            580                 585                 590         


Ala Lys Leu Phe Phe Ser His Phe Gln Arg Ile Cys Phe Asn Ala Glu 
        595                 600                 605             


Lys Asp Trp Phe Glu Phe Ser Phe Asp Tyr Asn Asp Phe Thr Thr Lys 
    610                 615                 620                 


Ala Glu Gly Thr Arg Thr Gln Trp Thr Leu Cys Ser Tyr Gly Thr Arg 
625                 630                 635                 640 


Ile Arg Asn Phe Arg Asn Pro Leu Gln Asn His Gln Trp Asp Asp Glu 
                645                 650                 655     


Glu Ile Val Leu Thr Glu Ala Phe Lys Ala Leu Phe Asp Lys Tyr Asp 
            660                 665                 670         


Ile Asp Ile His Ala Asn Leu Lys Glu Ala Ile Asn Ala Gln Thr Asp 
        675                 680                 685             


Ala Gln Phe Phe Lys Asp Leu Met Gly Leu Met Lys Leu Leu Leu Gln 
    690                 695                 700                 


Met Arg Asn Ser Lys Thr Asn Ser Glu Val Asp Tyr Leu Leu Ser Pro 
705                 710                 715                 720 


Val Ala Asp Glu His Gly Arg Phe Phe Asp Ser Arg Ala Gly Ala Gly 
                725                 730                 735     


Ser Leu Pro Asp Asn Ala Asp Ala Asn Gly Ala Tyr Asn Ile Ala Arg 
            740                 745                 750         


Lys Gly Leu Trp Val Ile Arg Lys Ile Gln Glu Thr Pro Glu Gly Glu 
        755                 760                 765             


Lys Leu Ser Leu Ala Ile Thr Asn Lys Glu Trp Leu Glu Phe Ala Gln 
    770                 775                 780                 


Thr Lys Pro Tyr Leu Asn Asp 
785                 790     


<210> 550
<211> 1262
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 550
Met Asn Leu Asn Thr Tyr Phe Ser Gln Phe Thr Gly Leu Tyr Pro Val 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Met Gly Lys Thr Leu Glu 
            20                  25                  30          


Lys Ile Lys Glu Thr Gly Ile Ile Glu Asn Asp Lys Lys Arg His Asn 
        35                  40                  45              


Asp Tyr Phe Asp Ala Lys Lys Ile Ile Asp Lys Tyr His Lys Tyr Phe 
    50                  55                  60                  


Ile Asp Ala Ala Leu Ser Lys Phe Pro Cys Ile Asp Trp Asn Pro Leu 
65                  70                  75                  80  


Lys Glu Ala Ile Glu Arg Ser Leu Asp Arg Ser Asp Ala Ser Lys Lys 
                85                  90                  95      


Lys Leu Glu Lys Thr Gln Thr Glu Phe Arg Lys Lys Ile Ala Lys Ala 
            100                 105                 110         


Leu Thr Thr His Gly His Tyr Lys Glu Leu Thr Ala Ser Thr Pro Lys 
        115                 120                 125             


Asp Leu Phe Leu Lys Val Phe Pro Asp His Phe Gly Lys Gln Pro Ala 
    130                 135                 140                 


Ile Asp Thr Phe Asp Gly Phe Ser Ser Tyr Phe Thr Gly Phe Gln Glu 
145                 150                 155                 160 


Asn Arg Gln Asn Ile Tyr Ser Asp Glu Ala Ile Ser Thr Ala Ile Pro 
                165                 170                 175     


Tyr Arg Leu Val His Asp Asn Phe Pro Lys Phe Leu Ser Asn Ile Glu 
            180                 185                 190         


Val Tyr Asn Ile Leu Lys Asp Asn Ala Pro Ser Val Leu Ser Asp Ala 
        195                 200                 205             


Glu Asn Glu Leu Lys Asp Phe Leu Asn Gly Lys Pro Leu Ala Asn Ile 
    210                 215                 220                 


Phe Glu Leu Asn Ala Tyr Asn Asp Val Leu Thr Gln Ser Gly Ile Asp 
225                 230                 235                 240 


Phe Phe Asn Gln Val Ile Gly Gly Phe Ser Gly Glu Gly Gly Glu Lys 
                245                 250                 255     


Lys Thr Arg Gly Ile Asn Glu Phe Ser Asn Leu Tyr Arg Gln Gln His 
            260                 265                 270         


Pro Glu Phe Ala Gln Lys Arg Leu Ala Thr Lys Met Ile Pro Leu Tyr 
        275                 280                 285             


Lys Gln Ile Leu Ser Asp Arg Glu Thr Lys Ser Phe Ile Leu Glu Ser 
    290                 295                 300                 


Tyr Ser Thr Asp Ser Gln Val Gln Glu Ser Val Lys Glu Phe Phe Glu 
305                 310                 315                 320 


Ser Gln Ile Leu Asn Cys Asp Ile Ala Gly Arg Lys Val Asn Val Leu 
                325                 330                 335     


Lys Glu Leu Ser Ser Leu Ile Lys Arg Ile Thr Glu Phe Asp Leu Gly 
            340                 345                 350         


Ser Ile Tyr Val Asn Gln Glu Glu Leu Ser Ser Ile Ser Leu Glu Leu 
        355                 360                 365             


Phe Lys Ser Trp Asn Thr Ile Asn Ala Ile Leu Phe Lys Asn Ala Glu 
    370                 375                 380                 


Asn Arg Ile Gly Ser Ala Glu Lys Ala Ala Asn Lys Lys Lys Ile Asp 
385                 390                 395                 400 


Ala Trp Met Lys Ser Asn Glu Phe Ser Ile Ala Thr Leu Asn Leu Ala 
                405                 410                 415     


Ile Ala Glu Ser Asp Ser Glu Glu Ile Ser Arg Val Lys Ile Glu Ser 
            420                 425                 430         


Tyr Trp Asn Asn Phe Glu Ala Lys Val Gln Ser Ile Leu Cys Gly Asp 
        435                 440                 445             


Asn Arg Arg Asn Leu Asp Glu Phe Ile Ser Ala Thr Phe Asn Glu Asn 
    450                 455                 460                 


Asn Ala Leu Arg Glu Asp Ser Lys Val Ile Glu Lys Leu Lys Ala Phe 
465                 470                 475                 480 


Leu Asp Ala Leu Ile Glu Ile Met His Ser Ile Lys Pro Leu Ile Ser 
                485                 490                 495     


Asp Ala Glu Asn Arg Asp Leu Ser Phe Tyr Asn Glu Leu Met Pro Leu 
            500                 505                 510         


Tyr Asp Gln Leu Ser Leu Val Val Pro Leu Tyr Asn Lys Ile Arg Asn 
        515                 520                 525             


Tyr Ala Thr Gln Lys Leu Thr Glu Ser Glu Lys Phe Lys Leu Asn Phe 
    530                 535                 540                 


Asp Asn Pro Thr Leu Ala Asp Gly Trp Asp Gln Asn Lys Glu Glu Ala 
545                 550                 555                 560 


Asn Thr Ala Ile Leu Leu Leu Lys Asn Gly Leu Tyr Tyr Leu Gly Ile 
                565                 570                 575     


Met Asn Ala Lys Asn Lys Pro Lys Ile Lys Asp Phe Lys Thr Ser Glu 
            580                 585                 590         


Ser Glu Asp Cys Tyr Asp Lys Met Val Tyr Lys Leu Leu Pro Gly Pro 
        595                 600                 605             


Asn Lys Met Leu Pro Lys Val Phe Phe Ser Glu Lys Gly Leu Ala Thr 
    610                 615                 620                 


Phe Lys Pro Pro Lys Asp Ile Leu Asp Gly Tyr Asn Ala Gly Lys His 
625                 630                 635                 640 


Lys Lys Gly Asp Leu Phe Asp Ile Gly Phe Cys His Gln Leu Ile Asp 
                645                 650                 655     


Phe Phe Lys Glu Ser Ile Ala Lys His Pro Asp Trp Lys Lys Phe Asp 
            660                 665                 670         


Phe Lys Phe Ser Asp Thr Ser Ser Tyr Glu Asp Ile Ser Gly Phe Tyr 
        675                 680                 685             


Lys Glu Val Thr Asp Gln Gly Tyr Lys Ile Thr Phe Ser Lys Ile Pro 
    690                 695                 700                 


Thr Pro Gln Ile Asp Glu Trp Val Asn Glu Gly Lys Leu Phe Leu Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ala Pro Gly Ala Lys Gly Ser Pro Asn 
                725                 730                 735     


Leu His Thr Leu Tyr Trp Lys Ser Val Phe Ser Pro Glu Asn Leu Lys 
            740                 745                 750         


Asp Val Val Val Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr Arg Pro 
        755                 760                 765             


Ser Ser Val Lys Lys Pro Tyr Ser His Lys Val Gly Glu Lys Leu Val 
    770                 775                 780                 


Asn Arg Ile Gly Lys Asp Gly Leu Pro Leu Pro Glu Ser Val Phe Gly 
785                 790                 795                 800 


Glu Leu Phe Arg Tyr Phe Asn Gly Lys Leu Asp Gly Glu Leu Ser Asp 
                805                 810                 815     


Glu Ala Lys Arg Tyr Leu Asp Val Ala Val Val Lys Asp Val Lys His 
            820                 825                 830         


Glu Ile Val Lys Asp Arg Arg Tyr Thr Gln Asp Lys Phe Glu Phe His 
        835                 840                 845             


Val Pro Leu Thr Leu Asn Phe Lys Ala Asp Ser Lys Asn Glu Tyr Met 
    850                 855                 860                 


Asn Glu Arg Val Arg His Phe Leu Lys Asp Asn Pro Asp Val Asn Ile 
865                 870                 875                 880 


Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Met Thr Leu Ile 
                885                 890                 895     


Asn Gln Lys Gly Glu Ile Leu Lys Gln Lys Ser Phe Asn Ile Val Glu 
            900                 905                 910         


Ser Val Asn Tyr Gln Ala Lys Leu Val Gln Arg Glu Lys Glu Arg Asp 
        915                 920                 925             


Thr Ala Arg Arg Ser Trp Ser Ser Val Gly Lys Ile Lys Asp Leu Lys 
    930                 935                 940                 


Glu Gly Phe Leu Ser Gln Val Ile His Glu Ile Thr Thr Thr Met Ile 
945                 950                 955                 960 


Glu Asn Asn Ala Ile Val Val Leu Glu Asp Leu Asn Phe Gly Phe Lys 
                965                 970                 975     


Arg Gly Arg Phe Cys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys 
            980                 985                 990         


Met Leu Ile Asp Lys Leu Asn Tyr  Leu Val Phe Lys Asn  Lys Pro Glu 
        995                 1000                 1005             


Gly Asp  Val Gly Gly Val Leu  Lys Gly Tyr Gln Leu  Ala Glu Lys 
    1010                 1015                 1020             


Phe Asp  Ser Phe Gln Lys Leu  Gly Lys Gln Ser Gly  Phe Leu Phe 
    1025                 1030                 1035             


Tyr Ile  Pro Ala Ala Tyr Thr  Ser Lys Ile Asp Pro  Thr Thr Gly 
    1040                 1045                 1050             


Phe Ala  Asn Leu Phe Asn Met  Thr Glu Leu Thr Ser  Ala Glu Lys 
    1055                 1060                 1065             


Lys Lys  Glu Phe Leu Ser His  Phe Glu Asp Ile Thr  Tyr Asp Gly 
    1070                 1075                 1080             


Lys Asn  Asp Arg Phe Leu Phe  Ser Phe Asp Tyr Lys  Lys Phe Lys 
    1085                 1090                 1095             


Cys Phe  Gln Thr Asp Tyr Ile  Lys Lys Trp Thr Val  Tyr Ser Gln 
    1100                 1105                 1110             


Gly Lys  Arg Ile Val Tyr Asp  Lys Glu Ser Lys Ser  Ala Lys Ala 
    1115                 1120                 1125             


Ile Ser  Pro Val Glu Ile Ile  Lys Ala Ala Leu Ala  Lys Gln Asn 
    1130                 1135                 1140             


Ile Ala  Leu Thr Asp Gln Leu  Asp Val Leu Ser Ala  Ile Asn Ser 
    1145                 1150                 1155             


Val Glu  Ala Ser Arg Glu Thr  Ala Ser Phe Phe Gly  Asp Ile Cys 
    1160                 1165                 1170             


Tyr Ala  Phe Glu Lys Thr Leu  Gln Met Arg Asn Ser  Ile Pro Asn 
    1175                 1180                 1185             


Thr Asp  Glu Asp Tyr Leu Val  Ser Pro Val Met Asn  Lys Lys Gly 
    1190                 1195                 1200             


Glu Phe  Tyr Asp Ser Arg Ser  Cys Gly Asp Ser Leu  Pro Lys Asn 
    1205                 1210                 1215             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Tyr 
    1220                 1225                 1230             


Leu Ile  Lys Asn Val Phe Asp  Ala Gly Gly Lys Asp  Leu Lys Ile 
    1235                 1240                 1245             


Ser His  Glu Asp Trp Phe Lys  Phe Ala Gln Ser Arg  Asn Arg 
    1250                 1255                 1260         


<210> 551
<211> 1250
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 551
Met Gln Thr Leu Phe Glu Asn Phe Thr Asn Gln Tyr Pro Val Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Lys Asp Phe Ile 
            20                  25                  30          


Glu Gln Lys Gly Leu Leu Lys Lys Asp Glu Asp Arg Ala Glu Lys Tyr 
        35                  40                  45              


Lys Lys Val Lys Asn Ile Ile Asp Glu Tyr His Lys Asp Phe Ile Glu 
    50                  55                  60                  


Lys Ser Leu Asn Gly Leu Lys Leu Asp Gly Leu Glu Glu Tyr Lys Thr 
65                  70                  75                  80  


Leu Tyr Leu Lys Gln Glu Lys Asp Asp Lys Asp Lys Lys Ala Phe Asp 
                85                  90                  95      


Lys Glu Lys Glu Asn Leu Arg Lys Gln Ile Ala Asn Ala Phe Arg Asn 
            100                 105                 110         


Asn Glu Lys Phe Lys Thr Leu Phe Ala Lys Glu Leu Ile Lys Asn Asp 
        115                 120                 125             


Leu Met Ser Phe Ala Cys Glu Glu Asp Lys Lys Asn Val Lys Glu Phe 
    130                 135                 140                 


Glu Ala Phe Thr Thr Tyr Phe Thr Gly Phe His Gln Asn Arg Ala Asn 
145                 150                 155                 160 


Met Tyr Val Ala Asp Glu Lys Arg Thr Ala Ile Ala Ser Arg Leu Ile 
                165                 170                 175     


His Glu Asn Leu Pro Lys Phe Ile Asp Asn Ile Lys Ile Phe Glu Lys 
            180                 185                 190         


Met Lys Lys Glu Ala Pro Glu Leu Leu Ser Pro Phe Asn Gln Thr Leu 
        195                 200                 205             


Lys Asp Met Lys Asp Val Ile Lys Gly Thr Thr Leu Glu Glu Ile Phe 
    210                 215                 220                 


Ser Leu Asp Tyr Phe Asn Lys Thr Leu Thr Gln Ser Gly Ile Asp Ile 
225                 230                 235                 240 


Tyr Asn Ser Val Ile Gly Gly Arg Thr Pro Glu Glu Gly Lys Thr Lys 
                245                 250                 255     


Ile Lys Gly Leu Asn Glu Tyr Ile Asn Thr Asp Phe Asn Gln Lys Gln 
            260                 265                 270         


Thr Asp Lys Lys Lys Arg Gln Pro Lys Phe Lys Gln Leu Tyr Lys Gln 
        275                 280                 285             


Ile Leu Ser Asp Arg Gln Ser Leu Ser Phe Ile Ala Glu Ala Phe Lys 
    290                 295                 300                 


Asn Asp Thr Glu Ile Leu Glu Ala Ile Glu Lys Phe Tyr Val Asn Glu 
305                 310                 315                 320 


Leu Leu His Phe Ser Asn Glu Gly Lys Ser Thr Asn Val Leu Asp Ala 
                325                 330                 335     


Ile Lys Asn Ala Val Ser Asn Leu Glu Ser Phe Asn Leu Thr Lys Ile 
            340                 345                 350         


Tyr Phe Arg Ser Gly Thr Ser Leu Thr Asp Val Ser Arg Lys Val Phe 
        355                 360                 365             


Gly Glu Trp Ser Ile Ile Asn Arg Ala Leu Asp Asn Tyr Tyr Ala Thr 
    370                 375                 380                 


Thr Tyr Pro Ile Lys Pro Arg Glu Lys Ser Glu Lys Tyr Glu Glu Arg 
385                 390                 395                 400 


Lys Glu Lys Trp Leu Lys Gln Asp Phe Asn Val Ser Leu Ile Gln Thr 
                405                 410                 415     


Ala Ile Asp Glu Tyr Asp Asn Glu Thr Val Lys Gly Lys Asn Ser Gly 
            420                 425                 430         


Lys Val Ile Val Asp Tyr Phe Ala Lys Phe Cys Asp Asp Lys Glu Thr 
        435                 440                 445             


Asp Leu Ile Gln Lys Val Asn Glu Gly Tyr Ile Ala Val Lys Asp Leu 
    450                 455                 460                 


Leu Asn Thr Pro Tyr Pro Glu Asn Glu Lys Leu Gly Ser Asn Lys Asp 
465                 470                 475                 480 


Gln Val Lys Gln Ile Lys Ala Phe Met Asp Ser Ile Met Asp Ile Met 
                485                 490                 495     


His Phe Val Arg Pro Leu Ser Leu Lys Asp Thr Asp Lys Glu Lys Asp 
            500                 505                 510         


Glu Thr Phe Tyr Ser Leu Phe Thr Pro Leu Tyr Asp His Leu Thr Gln 
        515                 520                 525             


Thr Ile Ala Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Gln Lys Pro 
    530                 535                 540                 


Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Glu Asn Ser Thr Leu Leu 
545                 550                 555                 560 


Gly Gly Trp Asp Leu Asn Lys Glu Thr Asp Asn Thr Ala Ile Ile Leu 
                565                 570                 575     


Arg Lys Glu Asn Leu Tyr Tyr Leu Gly Ile Met Asp Lys Arg His Asn 
            580                 585                 590         


Arg Ile Phe Arg Asn Val Pro Lys Ala Asp Lys Lys Asp Ser Cys Tyr 
        595                 600                 605             


Glu Lys Met Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro 
    610                 615                 620                 


Lys Val Phe Phe Ser Gln Ser Arg Ile Gln Glu Phe Thr Pro Ser Ala 
625                 630                 635                 640 


Lys Leu Leu Glu Asn Tyr Glu Asn Glu Thr His Lys Lys Gly Asp Asn 
                645                 650                 655     


Phe Asn Leu Asn His Cys His Gln Leu Ile Asp Phe Phe Lys Asp Ser 
            660                 665                 670         


Ile Asn Lys His Glu Asp Trp Lys Asn Phe Asp Phe Arg Phe Ser Ala 
        675                 680                 685             


Thr Ser Thr Tyr Ala Asp Leu Ser Gly Phe Tyr His Glu Val Glu His 
    690                 695                 700                 


Gln Gly Tyr Lys Ile Ser Phe Gln Ser Ile Ala Asp Ser Phe Ile Asp 
705                 710                 715                 720 


Asp Leu Val Asn Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
                725                 730                 735     


Asp Phe Ser Pro Phe Ser Lys Gly Lys Pro Asn Leu His Thr Leu Tyr 
            740                 745                 750         


Trp Lys Met Leu Phe Asp Glu Asn Asn Leu Lys Asp Val Val Tyr Lys 
        755                 760                 765             


Leu Asn Gly Glu Ala Glu Val Phe Tyr Arg Lys Lys Ser Ile Ala Glu 
    770                 775                 780                 


Lys Asn Thr Thr Ile His Lys Ala Asn Glu Ser Ile Ile Asn Lys Asn 
785                 790                 795                 800 


Pro Asp Asn Pro Lys Ala Thr Ser Thr Phe Asn Tyr Asp Ile Val Lys 
                805                 810                 815     


Asp Lys Arg Tyr Thr Ile Asp Lys Phe Gln Phe His Val Pro Ile Thr 
            820                 825                 830         


Met Asn Phe Lys Ala Glu Gly Ile Phe Asn Met Asn Gln Arg Val Asn 
        835                 840                 845             


Gln Phe Leu Lys Ala Asn Pro Asp Ile Asn Ile Ile Gly Ile Asp Arg 
    850                 855                 860                 


Gly Glu Arg His Leu Leu Tyr Tyr Thr Leu Ile Asn Gln Lys Gly Lys 
865                 870                 875                 880 


Ile Leu Lys Gln Asp Thr Leu Asn Val Ile Ala Asn Glu Lys Gln Lys 
                885                 890                 895     


Val Asp Tyr His Asn Leu Leu Asp Lys Lys Glu Gly Asp Arg Ala Thr 
            900                 905                 910         


Ala Arg Gln Glu Trp Gly Val Ile Glu Thr Ile Lys Glu Leu Lys Glu 
        915                 920                 925             


Gly Tyr Leu Ser Gln Val Ile His Lys Leu Thr Asp Leu Met Ile Glu 
    930                 935                 940                 


Asn Asn Ala Ile Ile Val Met Glu Asp Leu Asn Phe Gly Phe Lys Arg 
945                 950                 955                 960 


Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met 
                965                 970                 975     


Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Asn Lys Lys Ala Asn 
            980                 985                 990         


Glu Leu Gly Gly Leu Leu Asn Ala  Phe Gln Leu Ala Asn  Lys Phe Glu 
        995                 1000                 1005             


Ser Phe  Gln Lys Met Gly Lys  Gln Asn Gly Phe Ile  Phe Tyr Val 
    1010                 1015                 1020             


Pro Ala  Trp Asn Thr Ser Lys  Thr Asp Pro Ala Thr  Gly Phe Ile 
    1025                 1030                 1035             


Asp Phe  Leu Lys Pro Arg Tyr  Glu Asn Leu Lys Gln  Ala Lys Asp 
    1040                 1045                 1050             


Phe Phe  Glu Lys Phe Asp Ser  Ile Arg Leu Asn Ser  Lys Ala Asp 
    1055                 1060                 1065             


Tyr Phe  Glu Phe Ala Phe Asp  Phe Lys Asn Phe Thr  Gly Lys Ala 
    1070                 1075                 1080             


Asp Gly  Gly Arg Thr Lys Trp  Thr Val Cys Thr Thr  Asn Glu Asp 
    1085                 1090                 1095             


Arg Tyr  Ala Trp Asn Arg Ala  Leu Asn Asn Asn Arg  Gly Ser Gln 
    1100                 1105                 1110             


Glu Lys  Tyr Asp Ile Thr Ala  Glu Leu Lys Ser Leu  Phe Asp Gly 
    1115                 1120                 1125             


Lys Val  Asp Tyr Lys Ser Gly  Lys Asp Leu Lys Gln  Gln Ile Ala 
    1130                 1135                 1140             


Ser Gln  Glu Leu Ala Asp Phe  Phe Arg Thr Leu Met  Lys Tyr Leu 
    1145                 1150                 1155             


Ser Val  Thr Leu Ser Leu Arg  His Asn Asn Gly Glu  Lys Gly Glu 
    1160                 1165                 1170             


Thr Glu  Gln Asp Tyr Ile Leu  Ser Pro Val Ala Asp  Ser Met Gly 
    1175                 1180                 1185             


Lys Phe  Phe Asp Ser Arg Lys  Ala Gly Asp Asp Met  Pro Lys Asn 
    1190                 1195                 1200             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Trp 
    1205                 1210                 1215             


Cys Leu  Glu Gln Ile Ser Lys  Thr Asp Asp Leu Lys  Lys Val Lys 
    1220                 1225                 1230             


Leu Ala  Ile Ser Asn Lys Glu  Trp Leu Glu Phe Met  Gln Thr Leu 
    1235                 1240                 1245             


Lys Gly  
    1250 


<210> 552
<211> 1390
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 552
Met Ile Asp Asn Thr Lys Glu Lys Lys Glu Gly Ser Val Phe Asp Gly 
1               5                   10                  15      


Phe Thr Arg Lys Tyr Gln Leu Ser Lys Thr Leu Arg Phe Glu Leu Arg 
            20                  25                  30          


Pro Ile Leu Asn Thr Pro Lys Met Leu Asp Asp Glu Gln Val Ile Lys 
        35                  40                  45              


Asn Asp Glu Thr Arg Arg Lys Lys Tyr Glu Ala Val Lys Pro Trp Phe 
    50                  55                  60                  


Asp Gln Leu His Arg Glu Phe Ile Glu Asp Ala Leu Lys Ser Phe Lys 
65                  70                  75                  80  


Phe Lys Asn Leu Ala Ile Tyr Gln Asp Thr Phe Gln Thr Trp Gln Lys 
                85                  90                  95      


Asp Arg Lys Ser Lys Gln Lys Lys Asp Thr Leu Val Lys Ile Glu Val 
            100                 105                 110         


Gly Leu Arg Glu Glu Ile Val Arg Arg Phe Glu Glu Val Ala Asn Ile 
        115                 120                 125             


Trp Val Arg Ser Glu Gln Tyr Lys Leu Leu Gly Ile Lys Lys Glu Gly 
    130                 135                 140                 


Leu Gly Met Leu Phe Glu Ala Gly Val Phe Arg Leu Leu Lys Glu Arg 
145                 150                 155                 160 


Phe Lys Asn Glu Lys Asp Thr Thr Val Asp Gly Asn Asn Ile Phe Asp 
                165                 170                 175     


Glu Trp Thr Arg Trp Thr Gly Tyr Phe Lys Lys Phe Phe Glu Thr Arg 
            180                 185                 190         


Lys Asn Phe Tyr Lys Ser Asp Asp Thr Ser Thr Ala Ile Ala Tyr Arg 
        195                 200                 205             


Val Ile Asn Gln Asn Leu Arg Arg Phe Cys Glu Asn Ile Gln Ile Phe 
    210                 215                 220                 


Glu Lys Ile Ser Glu Lys Ile Glu Phe Ser Glu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Asp Ile Ser Cys Ala Gly Ile Phe Ser Leu Ala Tyr Tyr Asn Ala Cys 
                245                 250                 255     


Leu Leu Gln Gly Gly Ile Asp Thr Tyr Asn Lys Ile Ile Gly Gly Glu 
            260                 265                 270         


Val Asp Glu Lys Asp Lys Lys Ile Pro Gly Ile Asn Glu Leu Ile Asn 
        275                 280                 285             


Lys Tyr Arg Gln Asp Asn Ser Gly Glu Lys Ile Pro Phe Leu Lys Gln 
    290                 295                 300                 


Leu Asp Lys Gln Ile His Ser Ala Lys Glu Ala Phe Ile Glu Ser Ile 
305                 310                 315                 320 


Glu Thr Asn Lys Glu Leu Val Gly Lys Leu Lys Thr Phe Tyr Glu Asn 
                325                 330                 335     


Ala Glu Val Lys Ile Gln Ser Phe Arg Asn Leu Ile Ala Asp Ile Val 
            340                 345                 350         


Thr Asp Tyr Ser Gly Tyr Asp Ile Asp Lys Ile Tyr Leu Thr Lys Glu 
        355                 360                 365             


Ala Val Ser His Asn Ala Ser Arg Trp Phe Ala Ser Phe Glu Ser Phe 
    370                 375                 380                 


Glu Arg Asp Leu Phe Ala Val Val Ala Glu Lys Gln Asn Lys Leu Val 
385                 390                 395                 400 


Tyr Glu Leu Leu Arg Thr His Lys Asn Asp Ser Lys Ile Ser Asp Lys 
                405                 410                 415     


Asp Gly Lys Phe Ser Phe Pro Asp Phe Ile Lys Cys Ser His Ile Lys 
            420                 425                 430         


Arg Ala Leu Glu Lys Gln Glu Gly Arg Ile Trp Lys Gly Glu Tyr Tyr 
        435                 440                 445             


Glu Asp Ile Val Asp Phe Glu Lys Ile Lys Asp Val Phe Thr Gln Phe 
    450                 455                 460                 


Leu Cys Val Phe Lys Phe Glu Leu Glu Gln Gln Phe Phe Arg Lys Thr 
465                 470                 475                 480 


Thr Ser Ala Gln Thr Gly Glu Gln Thr Lys Ile Gly Tyr Glu Ile Phe 
                485                 490                 495     


Val Thr Lys Ile Asn Glu Leu Ile Thr Arg Glu Asn Pro Val Ile Asp 
            500                 505                 510         


Leu Glu Glu Lys Ile Ala Ile Lys Asn Phe Ala Asp Ala Thr Leu Leu 
        515                 520                 525             


Ile Tyr Gln Ile Ala Lys Tyr Phe Ala Val Glu Lys Arg Arg Gly Trp 
    530                 535                 540                 


Leu Asp Asn Tyr Asp Leu Asp Asp Arg Phe Tyr Lys Ser Ser Asp Ile 
545                 550                 555                 560 


Gly Tyr Leu Asn Phe Tyr Arg Asp Ala Phe Glu Gln Ile Val Arg Pro 
                565                 570                 575     


Tyr Asn Leu Phe Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Asn Thr Asn 
            580                 585                 590         


Lys Trp Val Leu Ser Phe Glu Asn Pro Thr Leu Ala Asp Gly Trp Asp 
        595                 600                 605             


Lys Asn Lys Glu Lys Thr Asn Ala Ala Val Ile Leu Arg Lys Asp Gly 
    610                 615                 620                 


Arg Tyr Tyr Leu Gly Ile Ile Lys Glu Asp Cys Lys Ser Leu Phe Ala 
625                 630                 635                 640 


Asp Arg Tyr Ser Lys Glu Met Ser Glu Gly Ile Glu Ser Gly Ser Phe 
                645                 650                 655     


Gln Lys Met Ala Tyr Lys Phe Phe Pro Glu Ala Ser Lys Met Ile Pro 
            660                 665                 670         


Lys Cys Ser Thr Gln Thr Lys Asn Val Lys Glu His Phe Arg Lys Ser 
        675                 680                 685             


Ser Ser Asp Tyr Asn Leu Phe His Glu Lys Asp Tyr Lys Ile Ser Val 
    690                 695                 700                 


Ala Ile Thr Lys Asn Ile Tyr Glu Leu Asn Asn Val Phe Tyr Arg Lys 
705                 710                 715                 720 


Asp Asn Ile Glu Glu Ser Phe Val Pro Lys Asn Asp Phe Glu Lys Lys 
                725                 730                 735     


Leu Gly Val Lys Lys Phe Gln Arg Gln Tyr Leu Glu Ile Ser Arg Asp 
            740                 745                 750         


Asn Asn Gly Tyr Lys Gln Ala Leu Ala Gln Trp Ile Glu Phe Cys Ile 
        755                 760                 765             


Arg Phe Leu Lys Ala Tyr Lys Ser Thr Thr Ile Phe Asp Tyr Ser Arg 
    770                 775                 780                 


Leu Arg Glu Ala Lys Glu Tyr Glu Ser Leu Asp Ala Phe Tyr Gln Asp 
785                 790                 795                 800 


Ile Asn Ala Leu Thr Tyr Asn Ile Ser Phe Val Pro Ile Ser Glu Gln 
                805                 810                 815     


Tyr Ile Lys Glu Lys Asn Asp Asn Gly Glu Leu Phe Leu Phe Glu Ile 
            820                 825                 830         


Tyr Asn Lys Asp Trp Ser Leu Gly Pro Met Asp Lys Asn Arg Lys Arg 
        835                 840                 845             


Thr Lys Asn Leu His Thr Leu Tyr Phe Glu Gln Leu Phe Ser Lys Glu 
    850                 855                 860                 


Asn Glu Gln Glu Asn Phe Leu Phe Gln Leu Asn Gly Glu Ala Glu Leu 
865                 870                 875                 880 


Phe Phe Arg Pro Lys Thr Glu Glu Lys Arg Leu Gly Tyr Lys Val Trp 
                885                 890                 895     


Asp Ala Gly Glu Lys Lys Trp Val Lys Ala Lys Glu Lys Glu Asp Gly 
            900                 905                 910         


Ala Val Ile Asp Arg Lys Arg Tyr Ala Lys Asp Ile Ile Leu Phe His 
        915                 920                 925             


Cys Pro Ile Thr Leu Asn Arg Val Ser Glu Ser Lys Thr Lys Arg Glu 
    930                 935                 940                 


Met Asp Val Glu Ile Arg Glu Val Leu Ser Ser Thr Pro Gly Val His 
945                 950                 955                 960 


Ile Ile Gly Val Asp Arg Gly Glu Lys His Leu Ala Tyr Tyr Ser Val 
                965                 970                 975     


Ile Asp Gln Asn Gly Lys Ile Ile Glu Thr Asp Thr Leu Asn Ser Ile 
            980                 985                 990         


Gly Lys Asp Gly Arg Gly Lys Pro  Val Glu Tyr Ala Ser  Lys Leu Glu 
        995                 1000                 1005             


Lys Arg  Ala Gln Glu Arg Glu  Ala Ser Arg Arg Asp  Trp Glu Glu 
    1010                 1015                 1020             


Val Glu  Ala Ile Lys Asp Leu  Lys Lys Gly Tyr Ile  Ser Gln Val 
    1025                 1030                 1035             


Ile Arg  Asn Leu Ala Asp Leu  Ile Ile Lys His Asn  Ala Ile Ile 
    1040                 1045                 1050             


Val Phe  Glu Asp Leu Asn Met  Arg Phe Lys Gln Ile  Arg Gly Gly 
    1055                 1060                 1065             


Ile Glu  Lys Ser Ala Tyr Gln  Gln Leu Glu Arg Ala  Leu Ile Asp 
    1070                 1075                 1080             


Lys Leu  Ser Phe Leu Val Lys  Lys Gly Glu Glu Asp  Pro Lys Gln 
    1085                 1090                 1095             


Thr Gly  His Ile Leu Arg Ala  Tyr Gln Leu Ala Ala  Pro Val Ile 
    1100                 1105                 1110             


Ala Phe  Lys Asp Met Gly Lys  Gln Thr Gly Leu Ile  Phe Tyr Thr 
    1115                 1120                 1125             


Gln Ala  Gly Tyr Thr Ser Lys  Thr Cys Pro Glu Cys  Gly Tyr Arg 
    1130                 1135                 1140             


Arg Asn  Ile Lys Cys Leu Phe  Glu Asn Ile Glu Gln  Ala Lys Thr 
    1145                 1150                 1155             


Leu Ile  Glu Asn Leu Glu Ser  Ile Asn Tyr Asn Lys  Lys Glu Asp 
    1160                 1165                 1170             


Val Phe  Gln Ile Ser Tyr Ser  Leu Glu Lys Leu Ser  Ser Lys Asp 
    1175                 1180                 1185             


Gln Lys  Lys Glu Lys Lys Val  Ser Asn Glu Leu Tyr  Ala Lys Thr 
    1190                 1195                 1200             


Leu Lys  Lys Asp Ile Phe Ile  Leu Thr Thr Lys Asn  Ala Leu Arg 
    1205                 1210                 1215             


Tyr Lys  Trp Tyr Asp Arg Tyr  Ser Glu Lys Ala Lys  Val Ala Lys 
    1220                 1225                 1230             


Arg Gly  Ile Asp Glu Tyr Lys  Gly Glu Val Asn Glu  Ser Glu Thr 
    1235                 1240                 1245             


Lys Lys  Gly Val Val Lys Glu  Phe Asn Leu Thr Glu  Tyr Leu Lys 
    1250                 1255                 1260             


Gly Leu  Leu Lys Thr Tyr Glu  Ile Asp Tyr Glu His  Gly Gly Ile 
    1265                 1270                 1275             


Arg Glu  Gln Ile Leu Ser Val  Ala Arg Gly Arg Glu  Phe Tyr Lys 
    1280                 1285                 1290             


Asp Phe  Leu Tyr Ala Leu Phe  Leu Leu Thr Glu Thr  Arg His Ser 
    1295                 1300                 1305             


Ile Ser  Gly Arg Asn Thr Asp  Tyr Ile Gln Cys Pro  Glu Cys Glu 
    1310                 1315                 1320             


Phe Asp  Ser Arg Lys Gly Phe  Lys Asp Ile Lys Glu  Phe Asn Gly 
    1325                 1330                 1335             


Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Arg Lys Gly  Ile Met Ile 
    1340                 1345                 1350             


Leu Glu  Lys Ile Lys Gln Phe  Lys Lys Asp Asn Asp  Gly Asn Leu 
    1355                 1360                 1365             


Glu Lys  Met Gly Trp Gly Asp  Leu Ser Ile Ser Ile  Glu Glu Trp 
    1370                 1375                 1380             


Asp Lys  Phe Thr Gln Lys Glu  
    1385                 1390 


<210> 553
<211> 1333
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 553
Met Lys Asn Phe Gln Asp Phe Thr Asn Leu Tyr Glu Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Ile Gly Gly Thr Lys Lys Leu Ile Glu 
            20                  25                  30          


Glu Lys Asn Ile Leu Lys Leu Asp Lys Lys Lys Arg Glu Asn Tyr Glu 
        35                  40                  45              


Lys Val Lys Pro Tyr Phe Asn Lys Ile His Gln Glu Phe Ile Asn Phe 
    50                  55                  60                  


Ala Leu Arg Asn Pro Asn Phe Asp Phe Ser Gln Phe Glu Glu Lys Tyr 
65                  70                  75                  80  


Leu Asn Trp Leu Lys Asp Lys Lys Asn Lys Asp Leu Leu Lys Glu Lys 
                85                  90                  95      


Glu Ser Ile Asp Lys Ile Phe Leu Glu Lys Ile Gly Lys Leu Phe Glu 
            100                 105                 110         


Asn Ser Val Lys Asp Phe Leu Lys Glu Asn Gly Phe Glu Ser Ile Val 
        115                 120                 125             


Lys Glu Glu Asp Gln Asn Leu Lys Phe Phe Arg Arg Lys Glu Ile Phe 
    130                 135                 140                 


Glu Val Leu Gln Glu Lys Tyr Gly Ser Glu Leu Glu Thr Gln Met Val 
145                 150                 155                 160 


Asn Lys Asp Gly Glu Ile Lys Ser Ile Phe Asn Gly Trp Glu Lys Trp 
                165                 170                 175     


Leu Gly Tyr Phe Asp Lys Phe Phe Asn Thr Arg Asp Asn Phe Tyr Lys 
            180                 185                 190         


Thr Asp Gly Thr Ser Thr Ala Ile Ala Thr Arg Ile Ile Lys Asp Asn 
        195                 200                 205             


Leu Lys Ile Phe Leu Glu Asn Ile Val Ala Phe Gly Lys Ile Lys Asn 
    210                 215                 220                 


Lys Lys Ile Asp Phe Ser Glu Val Glu Lys Asn Phe Ser Val Ser Ile 
225                 230                 235                 240 


Asp Thr Phe Phe Glu Ile Asn Asn Phe Asn Asn Cys Phe Leu Gln Asp 
                245                 250                 255     


Gly Ile Asp Phe Tyr Asn Lys Val Ile Gly Gly Glu Thr Leu Glu Asn 
            260                 265                 270         


Gly Glu Lys Leu Lys Gly Leu Asn Glu Ile Ile Asn Lys Tyr Arg Gln 
        275                 280                 285             


Asp Thr Gly Glu Lys Ile Pro Tyr Phe Lys Lys Leu Gln Lys Gln Ile 
    290                 295                 300                 


Leu Ser Glu Lys Asp Gly Val Phe Ile Asp Lys Ile Glu Asp Asp Gly 
305                 310                 315                 320 


Gly Phe Tyr Glu Val Leu Lys Asn Phe Tyr Lys Asn Ala Ala Glu Lys 
                325                 330                 335     


Glu Gly Phe Leu Lys Asn Ile Phe Glu Asn Phe Tyr Thr Ile Ser Asp 
            340                 345                 350         


Lys Asn Leu Glu Lys Ile Tyr Phe Asn Lys Ile Ala Phe Asn Thr Ile 
        355                 360                 365             


Ser His Lys Phe Gly Ser Ala Leu Glu Phe Glu Arg Ile Leu Tyr Glu 
    370                 375                 380                 


Glu Met Lys Lys Glu Lys Ala Asp Gly Ile Lys Phe Glu Lys Lys Glu 
385                 390                 395                 400 


Asn Lys Tyr Lys Phe Pro Asp Phe Ile Gln Ile Ile Phe Ile Lys Arg 
                405                 410                 415     


Ser Leu Glu Asn Tyr Asp Ser Glu Asn Leu Phe Trp Lys Glu Arg Tyr 
            420                 425                 430         


Tyr Lys Ser Glu Glu Asn Val Asp Gly Phe Leu Glu Lys Asn Asn Asn 
        435                 440                 445             


Asn Leu Trp Gly Gln Phe Cys Lys Ile Leu Asn Phe Glu Phe Leu Asn 
    450                 455                 460                 


Ile Leu Lys Arg Arg Ile Ile Asp Glu Ala Gly Glu Glu Tyr Glu Val 
465                 470                 475                 480 


Gly Phe Glu Ile Ser Lys Asn Ile Leu Gly Glu Lys Leu Glu Asn Phe 
                485                 490                 495     


Glu Leu Asn Gln Glu Asn Lys Gly Ile Ile Lys Asp Phe Ala Asp Tyr 
            500                 505                 510         


Ser Leu Ala Leu Tyr Ser Phe Gly Lys Tyr Phe Ala Val Glu Lys Gly 
        515                 520                 525             


Arg Asn Trp Asp Leu Asn Ile Asp Ile Ser Asp Asp Phe Tyr Gly Gly 
    530                 535                 540                 


Glu Asp Gly Tyr Ile Glu Lys Phe Tyr Asn Thr Gly Tyr Asp Glu Ile 
545                 550                 555                 560 


Val Lys Pro Tyr Asn Leu Met Arg Asn Tyr Ile Ser Lys Lys Pro Trp 
                565                 570                 575     


Glu Asp Asn Lys Lys Trp Lys Ile Asn Phe Glu Thr Ser Ser Leu Leu 
            580                 585                 590         


Ser Gly Trp Asp Lys Asn Leu Glu Ser Asn Gly Ser Tyr Ile Phe Gln 
        595                 600                 605             


Lys Gly Asn Lys Tyr Tyr Leu Gly Ile Ile Asn Gly Ser Lys Pro Ala 
    610                 615                 620                 


Lys Glu Ile Leu Glu Lys Leu Tyr Ser Gly Asp Gly Glu Lys Ile Lys 
625                 630                 635                 640 


Arg Phe Ile Tyr Asp Phe Gln Lys Pro Asp Asn Lys Asn Thr Pro Arg 
                645                 650                 655     


Met Phe Ile Arg Ser Lys Lys Asp Ser Phe Ser Pro Ala Val Glu Lys 
            660                 665                 670         


Tyr Asn Leu Pro Ile Asn Asp Ile Leu Glu Ile Tyr Asp Asn Gly Leu 
        675                 680                 685             


Phe Lys Thr Glu Asn Lys Gly Asn Pro Asn Tyr Lys Glu Ser Leu Arg 
    690                 695                 700                 


Lys Leu Ile Asp Tyr Phe Lys Leu Gly Phe Ser Arg His Glu Ser Phe 
705                 710                 715                 720 


Lys His Phe Asn Phe Val Trp Lys Asp Ser Lys Ser Tyr Glu Asn Ile 
                725                 730                 735     


Ala Asp Phe Tyr Arg Asp Val Glu Lys Ser Cys Tyr Lys Ile Asp Phe 
            740                 745                 750         


Glu Phe Leu Asn Phe Glu Glu Leu Lys Lys Leu Thr Phe Glu Lys His 
        755                 760                 765             


Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Glu Leu Asp Glu Ser 
    770                 775                 780                 


Leu Gln Glu Lys Gly Tyr Asn Phe Lys Gly Glu Gly Gln Lys Asn Ile 
785                 790                 795                 800 


His Thr Lys Tyr Phe Glu Ala Leu Phe Leu Glu Glu Asn Ile Ser Arg 
                805                 810                 815     


Lys Ser Gly Ala Val Phe Lys Leu Ser Gly Gly Gly Glu Val Phe Phe 
            820                 825                 830         


Arg Lys Lys Ser Ile Lys Ala Lys Lys Glu Lys Arg Asn Ser Val Glu 
        835                 840                 845             


Val Ile Lys Asn Lys Arg Tyr Thr Glu Cys Lys Tyr Phe Leu His Phe 
    850                 855                 860                 


Pro Ile Gln Val Asn Phe Lys Glu Glu Ile Ser Gly Asn Phe Asn Gln 
865                 870                 875                 880 


Glu Ile Asn Lys Phe Leu Ala Asn Asn Pro Asp Ile Asn Val Ile Gly 
                885                 890                 895     


Ile Asp Arg Gly Glu Lys His Leu Ala Tyr Phe Ser Val Ile Asn Gln 
            900                 905                 910         


Lys Gly Glu Ile Leu Glu Ser Gly Ser Phe Asn Lys Ile Glu Asn Tyr 
        915                 920                 925             


Asn Lys Asn Gly Glu Lys Leu Leu Phe Pro Glu Arg Glu Ile Lys Glu 
    930                 935                 940                 


Ile His Lys Asp Gly Ser Leu Ile Asp Leu Glu Leu Val Glu Thr Gly 
945                 950                 955                 960 


Arg Lys Val Asp Tyr Val Asp Tyr Lys Leu Leu Leu Glu Tyr Lys Glu 
                965                 970                 975     


Arg Lys Arg Leu Leu Gln Arg Gln Ser Trp Lys Glu Val Glu Gln Ile 
            980                 985                 990         


Lys Asp Leu Lys Lys Gly Tyr Ile  Ser Ala Leu Val Arg  Lys Ile Ala 
        995                 1000                 1005             


Asp Leu  Ile Ile Lys His Asn  Ala Ile Val Ile Phe  Glu Asp Leu 
    1010                 1015                 1020             


Asn Phe  Arg Phe Lys Gln Ile  Arg Gly Gly Ile Glu  Lys Ser Ile 
    1025                 1030                 1035             


Tyr Gln  Gln Leu Glu Lys Ala  Leu Ile Asp Lys Leu  Asn Phe Leu 
    1040                 1045                 1050             


Val Asn  Lys Asn Glu Ile Asn  Leu Glu Lys Ala Gly  Ser Ile Leu 
    1055                 1060                 1065             


Lys Ala  Tyr Gln Leu Thr Val  Pro Val Asp Ser Leu  Lys Glu Ile 
    1070                 1075                 1080             


Gly Lys  Gln Thr Gly Val Ile  Phe Tyr Thr Glu Ala  Ala Tyr Thr 
    1085                 1090                 1095             


Ser Lys  Ile Asp Pro Ile Thr  Gly Trp Arg Pro Asn  Leu Tyr Leu 
    1100                 1105                 1110             


Lys Lys  Asn Asn Ser Lys Ile  Asn Lys Glu Asn Ile  Leu Lys Phe 
    1115                 1120                 1125             


Asp Asn  Ile Val Phe Asn Ser  Lys Glu Asn Arg Phe  Glu Phe Thr 
    1130                 1135                 1140             


Tyr Asp  Leu Lys Lys Phe Phe  Gly Lys Asp Ser Lys  Phe Pro Ala 
    1145                 1150                 1155             


Lys Thr  Val Asn Thr Val Cys  Ser Cys Val Glu Arg  Phe Lys Trp 
    1160                 1165                 1170             


Asn Arg  Asn Leu Asn Asn Asn  Lys Gly Gly Tyr Ile  His Tyr Glu 
    1175                 1180                 1185             


Asn Leu  Thr Asp Gly Lys Leu  Ala Asn Lys Glu Gln  Lys Glu Asp 
    1190                 1195                 1200             


Glu Phe  Ser Asn Phe Lys Glu  Leu Phe Glu Lys Tyr  Phe Ile Asp 
    1205                 1210                 1215             


Ile Asn  Gly Asn Ile Leu Glu  Gln Ile Lys Asn Leu  Asp Thr Lys 
    1220                 1225                 1230             


Asn Asn  Glu Lys Phe Phe Ser  Ser Phe Ile Asp Leu  Phe Thr Leu 
    1235                 1240                 1245             


Val Cys  Gln Ile Arg Asn Thr  Asn Gln Asn Ala Lys  Gly Asp Glu 
    1250                 1255                 1260             


Asn Asp  Phe Ile Leu Ser Pro  Val Glu Pro Phe Phe  Asp Ser Arg 
    1265                 1270                 1275             


Lys Ser  Gln Asn Phe Gly Lys  Ser Leu Pro Lys Asn  Gly Asp Glu 
    1280                 1285                 1290             


Asn Gly  Ala Phe Asn Ile Ala  Arg Lys Gly Leu Ile  Ile Leu Asn 
    1295                 1300                 1305             


Arg Ile  Ser Glu Asn Pro Glu  Lys Pro Asp Leu Leu  Ile Phe Asn 
    1310                 1315                 1320             


Ala Asp  Trp Asp Asn Phe Ala  Arg Asn Ile 
    1325                 1330             


<210> 554
<211> 1329
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 554
Met Ser Asn Asn Phe Gln Glu Phe Thr Gln Lys Tyr Ala Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Lys Glu Ile Leu 
            20                  25                  30          


Glu Lys Glu Met Pro Met Tyr Gln Ile Ile Asn Ala Asp Lys Asn Ile 
        35                  40                  45              


Lys Ala Lys Tyr Ile Gln Thr Lys Pro Phe Phe Asp Gln Leu His Arg 
    50                  55                  60                  


Asp Phe Ile Lys Glu Ala Phe Glu Asn Val Glu Leu Ser Gly Leu Ser 
65                  70                  75                  80  


Asp Phe Phe Glu Asn Trp Lys Ile Tyr Lys Gln Asp Lys Lys Ala Asn 
                85                  90                  95      


Glu Lys Ile Tyr Lys Lys Ser Ala Glu Asn Leu Arg Lys Glu Val Val 
            100                 105                 110         


Ser Phe Leu Asn Ala Lys Gly Lys Asp Trp Ala Glu Lys Tyr His Ser 
        115                 120                 125             


Ser Gly Leu Lys Lys Ala Asp Ile Glu Ile Leu Phe Glu Glu Gly Ile 
    130                 135                 140                 


Phe Lys Val Leu Glu Ile Arg Tyr Gly Thr Asp Thr Asn Ser Phe Ile 
145                 150                 155                 160 


Thr Asn Ala Thr Thr Gly Glu Ile Thr Ser Ile Phe Gln Gly Trp Lys 
                165                 170                 175     


Gly Phe Thr Gly Tyr Phe Leu Lys Phe Trp Asn Thr Arg Glu Asn Tyr 
            180                 185                 190         


Tyr Lys Thr Asp Gly Thr Ser Thr Ala Ile Ala Thr Arg Ile Val Asp 
        195                 200                 205             


Gln Asn Leu Pro Gly Tyr Leu Glu Asn Leu Glu Ile Phe Glu Lys Met 
    210                 215                 220                 


Lys Gly Lys Ile Asp Phe Glu Ser Val Arg Gly Asp Phe Ser Asp Phe 
225                 230                 235                 240 


Glu Lys Ile Gly Thr Val Glu Tyr Tyr Ser Thr Cys Leu Leu Gln Glu 
                245                 250                 255     


Gly Ile Asp Gly Tyr Asn Arg Ile Ile Gly Gly Tyr Thr Tyr Glu Asn 
            260                 265                 270         


Gly Glu Lys Ile Lys Gly Ile Asn Glu Ile Ile Asn Leu Tyr Arg Gln 
        275                 280                 285             


Thr His Lys Asp Glu Lys Val Pro Phe Leu Lys Thr Leu Asp Lys Gln 
    290                 295                 300                 


Ile Gly Ser Glu Lys Ile Ala Phe Met Glu Thr Ile Asp Thr Pro Glu 
305                 310                 315                 320 


Glu Phe Arg Lys Ile Phe Glu Glu Phe Val Leu Lys Ser Ser Glu Lys 
                325                 330                 335     


Val Val Leu Leu Lys Gln Cys Leu Asn His Leu Phe Glu Asn Glu Leu 
            340                 345                 350         


Thr Asp Gly Val Phe Leu Ser Lys Glu Ser Leu Asn Thr Ile Ser His 
        355                 360                 365             


Lys Trp Ile Asp Ile Gly Asn Met Lys Leu Phe His Glu Ser Leu Phe 
    370                 375                 380                 


Thr Ile Leu Lys Lys Glu Gly Ala Lys Tyr Asp Ser Lys Glu Asp Glu 
385                 390                 395                 400 


Tyr Lys Phe Pro Asp Phe Ile Arg Ile Ser Asp Ile Lys Thr Ala Leu 
                405                 410                 415     


Val Lys Ile Thr Thr Glu Ser Phe Phe Trp Lys Asn Arg Tyr Leu Tyr 
            420                 425                 430         


Glu Lys Asp Glu Asn Pro Thr Gly Phe Leu Thr Ser Asp Asn Ser Leu 
        435                 440                 445             


Trp Glu Gly Phe Ile Gln Ile Phe Ser His Glu Phe Ser Ser Leu Phe 
    450                 455                 460                 


Glu Arg Thr Glu Lys Asp Glu Glu Gly Lys Asp Ile Gln Trp Gly Tyr 
465                 470                 475                 480 


Asp Ile Ser Leu Leu Asn Ile Gln Lys Leu Leu Glu Asn Asn Glu Tyr 
                485                 490                 495     


Asn Pro Asn Asp Glu Lys Asn Lys Ile Ile Ile Lys Ser Phe Ala Asp 
            500                 505                 510         


Asp Ile Leu Arg Ile Tyr Gln Met Gly Lys Tyr Phe Ala Leu Glu Lys 
        515                 520                 525             


Lys Arg Gln Trp Asn Pro Asp Asn Leu Glu Ile Gly Glu Phe Tyr Ser 
    530                 535                 540                 


His Pro Glu Ile Gly Tyr Asp Lys Phe Tyr Phe Asp Ser Tyr Lys Ile 
545                 550                 555                 560 


Ile Val Gln Gly Tyr Asn Asp Ile Arg Asn Tyr Leu Thr Lys Asn Pro 
                565                 570                 575     


Trp Ser Glu Glu Lys Trp Lys Leu Asn Phe Glu Asn Pro Thr Leu Ala 
            580                 585                 590         


Asn Gly Trp Asp Lys Asn Lys Glu Thr Asp Asn Ser Cys Ile Phe Leu 
        595                 600                 605             


Lys Arg Asp Asn Lys Phe Phe Leu Ala Leu Met Ser Arg Gly Asn Asn 
    610                 615                 620                 


Gln Val Phe Asp Glu Arg Asn Ile Gln Lys Phe Ala Gln Asn Ile Glu 
625                 630                 635                 640 


Gln Gly Lys Tyr Glu Lys Met Val Tyr Lys Tyr Met Lys Asp Val Ala 
                645                 650                 655     


Leu Gly Ile Pro Lys Ala Thr Thr Gln Leu Asn Ala Val Gln Glu His 
            660                 665                 670         


Phe Phe Gln Ser Asp Lys Asp Tyr Ile Ile Thr Lys Gly Gly Ser Ser 
        675                 680                 685             


Ile Gly Glu Phe Ile Lys Pro Leu Arg Val Thr Lys Arg Ile Phe Glu 
    690                 695                 700                 


Leu Asn Asn Arg Ile Tyr Pro Lys Asp Asn Leu Gly Ile Ser Phe Leu 
705                 710                 715                 720 


Arg Asn Gln Val Asn Lys Lys Glu Gln Lys Asn Tyr Ile Lys Ile Phe 
                725                 730                 735     


Gln Lys Glu Phe Ile Thr Leu Gly Gly Asp Glu Val Val Tyr Lys Lys 
            740                 745                 750         


Ala Val His Asp Trp Ile Asp Phe Cys Lys Glu Tyr Thr Lys Ser Tyr 
        755                 760                 765             


Pro Ser Cys Ala Tyr Phe Asp Tyr Ser Gly Leu Lys Asp Thr Lys Glu 
    770                 775                 780                 


Tyr Ser Ser Ile Asp Glu Phe Tyr Asn Asp Leu Asp Ser Phe Gly Tyr 
785                 790                 795                 800 


Gln Ile Ser Trp Gln Asp Ile Ser Ser Ser Tyr Ile Asp Glu Leu Val 
                805                 810                 815     


Glu Ser Gly Lys Leu Tyr Leu Phe Glu Ile Tyr Asn Gln Asp Phe Ser 
            820                 825                 830         


Asn Gly Lys Thr Gly Ala Lys Asn Leu His Thr Leu Tyr Phe Glu His 
        835                 840                 845             


Ile Phe Ser Lys Glu Asn Gln Glu Val Asn Phe Pro Leu Lys Leu Asn 
    850                 855                 860                 


Gly Gln Ala Glu Leu Phe Phe Arg Pro Lys Ser Ile Glu Ala Lys Gly 
865                 870                 875                 880 


Glu Asn Arg Lys Phe Asn Arg Glu Ile Ile Ala Lys Lys Arg Tyr Thr 
                885                 890                 895     


Glu Asp Lys Ile Phe Phe His Val Pro Leu Thr Leu Asn Arg Thr Glu 
            900                 905                 910         


Gly Asp Ile Tyr Gly Phe Asn Thr Glu Ile Asn Asn Phe Leu Ala His 
        915                 920                 925             


Asn Pro Asp Ile Asn Ile Ile Gly Ile Asp Arg Gly Glu Lys His Leu 
    930                 935                 940                 


Ala Tyr Tyr Ser Val Ile Asp Gln Lys Gly Asn Ile Ile Glu Ser Asp 
945                 950                 955                 960 


Ser Leu Asn Thr Val Asn Glu Ile Asn Tyr Gly Glu Lys Leu Thr Asp 
                965                 970                 975     


Thr Ala Glu Lys Arg Lys Gln Ala Arg Gln Asp Trp Gln Ala Val Glu 
            980                 985                 990         


Gly Ile Lys Asn Leu Lys Lys Gly  Tyr Ile Ser Ala Val  Val His Lys 
        995                 1000                 1005             


Leu Thr  Asp Leu Ile Ile Lys  Tyr Asn Ala Ile Val  Ile Phe Glu 
    1010                 1015                 1020             


Asp Leu  Asn Met Arg Phe Lys  Gln Ile Arg Gly Gly  Ile Glu Lys 
    1025                 1030                 1035             


Ser Val  Tyr Gln Gln Leu Glu  Lys Ala Leu Ile Glu  Lys Leu Asn 
    1040                 1045                 1050             


Tyr Leu  Val Glu Lys Gly Glu  Ile Asn Pro Glu Lys  Ala Gly His 
    1055                 1060                 1065             


Leu Leu  Asn Ala Tyr Gln Leu  Thr Ala Pro Phe Glu  Thr Phe Lys 
    1070                 1075                 1080             


Asp Met  Gly Lys Gln Thr Gly  Ile Val Phe Tyr Thr  Gln Ala Ala 
    1085                 1090                 1095             


Tyr Thr  Ser Lys Ile Asp Pro  Val Thr Gly Trp Arg  Pro His Leu 
    1100                 1105                 1110             


Tyr Leu  Lys Tyr Ser Ser Ala  Glu Gln Val Lys Lys  Glu Ile Ala 
    1115                 1120                 1125             


Lys Phe  Ser Asn Ile Ile Trp  Asn Asn Thr Glu Lys  Arg Phe Asp 
    1130                 1135                 1140             


Phe Met  Tyr Asp Ile Arg Asn  Phe Ser Thr Gln Lys  Glu Tyr Pro 
    1145                 1150                 1155             


Lys Asn  Asn Ile Trp Thr Val  Cys Ser Ser Val Glu  Arg Tyr Arg 
    1160                 1165                 1170             


Trp Asp  Lys Thr Leu Asn Gln  Asn Lys Gly Asp Tyr  Val His Tyr 
    1175                 1180                 1185             


Lys Ser  Ile Thr Pro Glu Phe  Glu Lys Leu Phe Ser  Asp Phe Gln 
    1190                 1195                 1200             


Ile Asp  Gly Thr Lys Asn Ile  Leu Glu Gln Ile Asn  Arg Met Glu 
    1205                 1210                 1215             


Thr Lys  Gly Asn Glu Lys Phe  Phe Lys Ser Phe Ile  Phe Phe Phe 
    1220                 1225                 1230             


Gly Leu  Ile Cys Gln Ile Arg  Asn Thr Asn Lys Ala  Asp Ser Asp 
    1235                 1240                 1245             


Glu Asn  Lys Gln Asp Phe Ile  Leu Ser Pro Val Val  Pro Phe Phe 
    1250                 1255                 1260             


Asp Ser  Arg Asp Ser Glu Asn  Thr Lys Asn Gly Leu  Pro Arg Asn 
    1265                 1270                 1275             


Gly Asp  Glu Asn Gly Ala Tyr  Asn Ile Ala Arg Lys  Gly Leu Ile 
    1280                 1285                 1290             


Ile Leu  Gln Lys Ile Asn Glu  Phe Ser Asp Glu Asn  Gly Asn Cys 
    1295                 1300                 1305             


Asp Lys  Leu Gly Trp Lys Glu  Leu Ser Ile Ser Gln  Val Asp Trp 
    1310                 1315                 1320             


Asp Asn  Tyr Ile Lys Thr 
    1325                 


<210> 555
<211> 841
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 555
Met Glu Tyr Asp Glu His Ile Ser Leu Ile Glu Ser Glu Glu Lys Ala 
1               5                   10                  15      


Asp Glu Met Lys Lys Arg Leu Asp Met Tyr Met Asn Met Tyr His Trp 
            20                  25                  30          


Ala Lys Ala Phe Ile Val Asp Glu Val Leu Asp Arg Asp Glu Met Phe 
        35                  40                  45              


Tyr Ser Asp Ile Asp Asp Ile Tyr Asn Ile Leu Glu Asn Ile Val Pro 
    50                  55                  60                  


Leu Tyr Asn Arg Val Arg Asn Tyr Val Thr Gln Lys Pro Tyr Thr Ser 
65                  70                  75                  80  


Lys Lys Ile Lys Leu Asn Phe Gln Ser Pro Thr Leu Ala Asn Gly Trp 
                85                  90                  95      


Ser Gln Ser Lys Glu Phe Asp Asn Asn Ala Ile Ile Leu Ile Arg Asp 
            100                 105                 110         


Asn Lys Tyr Tyr Leu Ala Ile Phe Asn Ala Lys Asn Lys Pro Asp Lys 
        115                 120                 125             


Lys Ile Ile Gln Gly Asn Ser Asp Lys Lys Asn Asp Asn Asp Tyr Lys 
    130                 135                 140                 


Lys Met Val Tyr Asn Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys 
145                 150                 155                 160 


Val Phe Leu Ser Lys Lys Gly Ile Glu Thr Phe Lys Pro Ser Asp Tyr 
                165                 170                 175     


Ile Ile Ser Gly Tyr Asn Ala His Lys His Ile Lys Thr Gly Glu Asn 
            180                 185                 190         


Phe Asp Ile Ser Phe Cys Arg Asp Leu Ile Asp Tyr Phe Lys Asn Ser 
        195                 200                 205             


Ile Glu Lys His Ala Glu Trp Arg Lys Tyr Glu Phe Lys Phe Ser Ala 
    210                 215                 220                 


Thr Asp Ser Tyr Asn Asp Ile Ser Glu Phe Tyr Arg Glu Val Glu Met 
225                 230                 235                 240 


Gln Gly Tyr Arg Ile Asp Trp Thr Tyr Ile Ser Glu Ala Asp Ile Asn 
                245                 250                 255     


Lys Leu Asp Glu Glu Gly Lys Ile Tyr Leu Phe Gln Ile Tyr Asn Lys 
            260                 265                 270         


Asp Phe Ala Glu Asn Ser Thr Gly Lys Glu Asn Leu His Thr Met Tyr 
        275                 280                 285             


Phe Lys Asn Ile Phe Ser Glu Glu Asn Leu Lys Asn Ile Val Ile Lys 
    290                 295                 300                 


Leu Asn Gly Gln Ala Glu Leu Phe Tyr Arg Lys Ala Ser Val Lys Asn 
305                 310                 315                 320 


Pro Val Lys His Lys Lys Asp Ser Val Leu Val Asn Lys Thr Tyr Lys 
                325                 330                 335     


Asn Gln Leu Asp Asn Gly Asp Val Val Arg Ile Pro Ile Pro Asp Asp 
            340                 345                 350         


Ile Tyr Asn Glu Ile Tyr Lys Met Tyr Asn Gly Tyr Ile Lys Glu Ser 
        355                 360                 365             


Asp Leu Ser Gly Ala Ala Lys Glu Tyr Leu Asp Lys Val Glu Val Arg 
    370                 375                 380                 


Thr Ala Gln Lys Glu Ile Val Lys Asp Tyr Arg Tyr Thr Val Asp Lys 
385                 390                 395                 400 


Tyr Phe Ile His Thr Pro Ile Thr Ile Asn Tyr Lys Val Thr Ala Arg 
                405                 410                 415     


Asn Asn Val Asn Asp Met Ala Val Lys Tyr Ile Ala Gln Asn Asp Asp 
            420                 425                 430         


Ile His Val Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Ile Tyr Ile 
        435                 440                 445             


Ser Val Ile Asp Ser His Gly Asn Ile Val Lys Gln Lys Ser Tyr Asn 
    450                 455                 460                 


Ile Leu Asn Asn Tyr Asp Tyr Lys Lys Lys Leu Val Glu Lys Glu Lys 
465                 470                 475                 480 


Thr Arg Glu Tyr Ala Arg Lys Asn Trp Lys Ser Ile Gly Asn Ile Lys 
                485                 490                 495     


Glu Leu Lys Glu Gly Tyr Ile Ser Gly Val Val His Glu Ile Ala Met 
            500                 505                 510         


Leu Met Val Glu Tyr Asn Ala Ile Ile Ala Met Glu Asp Leu Asn Tyr 
        515                 520                 525             


Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Arg Gln Val Tyr Gln Lys 
    530                 535                 540                 


Phe Glu Ser Met Leu Ile Asn Lys Leu Asn Tyr Phe Ala Ser Lys Gly 
545                 550                 555                 560 


Lys Ser Val Asp Glu Pro Gly Gly Leu Leu Lys Gly Tyr Gln Leu Thr 
                565                 570                 575     


Tyr Val Pro Asp Asn Ile Lys Asn Leu Gly Lys Gln Cys Gly Val Ile 
            580                 585                 590         


Phe Tyr Val Pro Ala Ala Phe Thr Ser Lys Ile Asp Pro Ser Thr Gly 
        595                 600                 605             


Phe Ile Ser Ala Phe Asn Phe Lys Ser Ile Ser Thr Asn Ala Ser Arg 
    610                 615                 620                 


Lys Gln Phe Phe Met Gln Phe Asp Glu Ile Arg Tyr Cys Ala Glu Lys 
625                 630                 635                 640 


Asp Met Phe Ser Phe Gly Phe Asp Tyr Asn Asn Phe Asp Thr Tyr Asn 
                645                 650                 655     


Ile Thr Met Gly Lys Thr Gln Trp Thr Val Tyr Thr Asn Gly Glu Arg 
            660                 665                 670         


Leu Gln Ser Glu Phe Asn Asn Ala Arg Arg Thr Gly Lys Thr Lys Ser 
        675                 680                 685             


Ile Asn Leu Thr Glu Thr Ile Lys Leu Leu Leu Lys Asp Asn Glu Ile 
    690                 695                 700                 


Asn Tyr Ala Asp Gly His Asp Val Arg Ile Asp Met Glu Lys Met Asp 
705                 710                 715                 720 


Glu Asp Lys Asn Ser Glu Phe Phe Ala Gln Leu Leu Ser Leu Tyr Lys 
                725                 730                 735     


Leu Thr Val Gln Met Arg Asn Ser Tyr Thr Glu Ala Glu Glu Gln Glu 
            740                 745                 750         


Lys Gly Ile Ser Tyr Asp Lys Ile Ile Ser Pro Val Ile Asn Asp Glu 
        755                 760                 765             


Gly Glu Phe Phe Asp Ser Asp Asn Tyr Lys Glu Ser Asp Asp Lys Glu 
    770                 775                 780                 


Cys Lys Met Pro Lys Asp Ala Asp Ala Asn Gly Ala Tyr Cys Ile Ala 
785                 790                 795                 800 


Leu Lys Gly Leu Tyr Glu Val Leu Lys Ile Lys Ser Glu Trp Thr Glu 
                805                 810                 815     


Asp Gly Phe Asp Arg Asn Cys Leu Lys Leu Pro His Ala Glu Trp Leu 
            820                 825                 830         


Asp Phe Ile Gln Asn Lys Arg Tyr Glu 
        835                 840     


<210> 556
<211> 886
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 556
Met Phe Gly Asn Trp Gly Val Ile Gln Asn Ala Val Met Gln Asn Ile 
1               5                   10                  15      


Lys Arg Val Ala Pro Ala Arg Lys His Lys Glu Ser Glu Glu Asp Tyr 
            20                  25                  30          


Glu Lys Arg Ile Ala Gly Ile Phe Lys Lys Ala Asp Ser Phe Ser Ile 
        35                  40                  45              


Ser Tyr Ile Asn Asp Cys Leu Asn Glu Ala Asp Pro Asn Asn Ala Tyr 
    50                  55                  60                  


Phe Val Glu Asn Tyr Phe Ala Thr Phe Gly Ala Val Asn Thr Pro Thr 
65                  70                  75                  80  


Met Gln Arg Glu Asn Leu Phe Ala Leu Val Gln Asn Ala Tyr Thr Glu 
                85                  90                  95      


Ile Thr Ala Leu Leu His Ser Asp Tyr Pro Thr Glu Lys Asn Leu Ala 
            100                 105                 110         


Gln Asp Lys Ala Asn Val Ala Lys Ile Lys Ala Leu Leu Asp Ala Ile 
        115                 120                 125             


Lys Ser Leu Gln His Phe Val Lys Pro Leu Leu Gly Lys Gly Asp Glu 
    130                 135                 140                 


Ser Asp Lys Asp Glu Arg Phe Tyr Gly Glu Leu Ala Ser Leu Trp Ala 
145                 150                 155                 160 


Glu Leu Asp Thr Met Thr Pro Leu Tyr Asn Met Ile Arg Asn Tyr Met 
                165                 170                 175     


Thr Arg Lys Pro Tyr Ser Gln Lys Lys Ile Lys Leu Asn Phe Glu Asn 
            180                 185                 190         


Pro Gln Leu Leu Gly Gly Trp Asp Ala Asn Lys Glu Lys Asp Tyr Ala 
        195                 200                 205             


Thr Ile Ile Leu Arg Arg Asn Gly Leu Tyr Tyr Leu Ala Ile Met Asn 
    210                 215                 220                 


Lys Asp Ser Lys Lys Leu Leu Gly Lys Ala Met Pro Ser Asp Gly Glu 
225                 230                 235                 240 


Cys Tyr Glu Lys Met Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met 
                245                 250                 255     


Leu Pro Lys Val Phe Phe Ala Lys Ser Arg Met Glu Asp Phe Lys Pro 
            260                 265                 270         


Ser Lys Glu Leu Val Glu Lys Tyr Asn Asn Gly Thr His Lys Lys Gly 
        275                 280                 285             


Lys Asn Phe Asn Ile Gln Asp Cys His Asn Leu Ile Asp Tyr Phe Lys 
    290                 295                 300                 


Gln Ser Ile Asp Lys His Glu Asp Trp Ser Lys Phe Gly Phe Lys Phe 
305                 310                 315                 320 


Ser Asp Thr Ser Thr Tyr Glu Asp Leu Ser Gly Phe Tyr Arg Glu Val 
                325                 330                 335     


Glu Gln Gln Gly Tyr Lys Leu Ser Phe Ala Arg Val Ser Val Ser Tyr 
            340                 345                 350         


Ile Asn Gln Leu Val Glu Glu Gly Lys Met Tyr Leu Phe Gln Ile Tyr 
        355                 360                 365             


Asn Lys Asp Phe Ser Glu Tyr Ser Lys Gly Thr Pro Asn Met His Thr 
    370                 375                 380                 


Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn Leu Ala Asp Val Val 
385                 390                 395                 400 


Tyr Lys Leu Asn Gly Gln Ala Glu Met Phe Tyr Arg Lys Lys Ser Ile 
                405                 410                 415     


Glu Asn Thr His Pro Thr His Pro Ala Asn His Pro Ile Leu Asn Lys 
            420                 425                 430         


Asn Lys Asp Asn Asn Lys Lys Glu Ser Leu Phe Glu Tyr Asp Leu Ile 
        435                 440                 445             


Lys Asp Arg Arg Tyr Thr Val Asp Lys Phe Met Phe His Val Pro Ile 
    450                 455                 460                 


Thr Met Asn Phe Lys Ser Ser Gly Ser Glu Asn Ile Asn Gln Asp Val 
465                 470                 475                 480 


Lys Ala Tyr Leu Cys His Ala Asp Asp Met His Ile Ile Gly Ile Asp 
                485                 490                 495     


Arg Gly Glu Arg His Leu Leu Tyr Leu Val Val Ile Asp Leu Gln Gly 
            500                 505                 510         


Asn Ile Lys Glu Gln Phe Ser Leu Asn Glu Ile Val Asn Asp Tyr Asn 
        515                 520                 525             


Gly Asn Thr Tyr His Thr Asn Tyr His Asp Leu Leu Asp Val Arg Glu 
    530                 535                 540                 


Asp Glu Arg Leu Lys Ala Arg Gln Ser Trp Gln Thr Ile Glu Asn Ile 
545                 550                 555                 560 


Lys Glu Leu Lys Glu Gly Tyr Leu Ser Gln Val Ile His Lys Ile Thr 
                565                 570                 575     


Gln Leu Met Val Lys Tyr His Ala Ile Val Val Leu Glu Asp Leu Asn 
            580                 585                 590         


Met Gly Phe Met Arg Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln 
        595                 600                 605             


Lys Phe Glu Lys Met Leu Ile Glu Lys Leu Asn Tyr Leu Val Asp Lys 
    610                 615                 620                 


Lys Ala Asp Ala Ser Val Ser Gly Gly Leu Leu Asn Ala Tyr Gln Leu 
625                 630                 635                 640 


Thr Ser Lys Phe Asp Ser Phe Gln Lys Leu Gly Lys Gln Ser Gly Phe 
                645                 650                 655     


Leu Phe Tyr Ile Pro Ala Trp Asn Thr Ser Lys Ile Asp Pro Val Thr 
            660                 665                 670         


Gly Phe Val Asn Leu Leu Asp Thr Arg Tyr Gln Asn Val Glu Lys Ala 
        675                 680                 685             


Lys Ser Phe Phe Ser Lys Phe Asp Ala Ile Arg Tyr Asn Lys Asp Lys 
    690                 695                 700                 


Glu Trp Phe Glu Phe Asn Leu Asp Tyr Asp Lys Phe Gly Lys Lys Ala 
705                 710                 715                 720 


Glu Gly Thr Arg Thr Lys Trp Thr Leu Cys Thr Arg Gly Met Arg Ile 
                725                 730                 735     


Asp Thr Phe Arg Asn Lys Glu Lys Asn Ser Gln Trp Asp Asn Gln Glu 
            740                 745                 750         


Val Asp Leu Thr Ala Glu Met Lys Ser Leu Leu Glu His Tyr Tyr Ile 
        755                 760                 765             


Asp Ile His Ser Asn Leu Lys Asp Ala Ile Ser Ala Gln Thr Asp Lys 
    770                 775                 780                 


Ala Phe Phe Thr Gly Leu Leu His Ile Leu Lys Leu Thr Leu Gln Met 
785                 790                 795                 800 


Arg Asn Ser Ile Thr Gly Thr Glu Thr Asp Tyr Leu Val Ser Pro Val 
                805                 810                 815     


Val Asp Glu Asn Gly Ile Phe Tyr Asp Ser Arg Ser Cys Gly Asp Glu 
            820                 825                 830         


Leu Pro Glu Asn Ala Asp Ala Asn Gly Ala Tyr Asn Ile Ala Arg Lys 
        835                 840                 845             


Gly Leu Met Met Ile Glu Gln Ile Lys Asp Ala Lys Asp Leu Asp Asn 
    850                 855                 860                 


Leu Lys Phe Asp Ile Ser Asn Lys Ala Trp Leu Asn Phe Ala Gln Gln 
865                 870                 875                 880 


Lys Pro Tyr Lys Asn Gly 
                885     


<210> 557
<211> 1228
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 557
Met Ser Asn Leu Tyr Ser Asn Leu His Asn Leu Tyr Gln Val Gln Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Gln Gly Lys Thr Lys Glu Asn Met 
            20                  25                  30          


Glu Lys Val Gly Ile Leu Lys Ala Asp Glu His Arg Ala Glu Ile Tyr 
        35                  40                  45              


Ser Lys Val Lys Lys Tyr Cys Asp Glu Tyr His Lys Leu Phe Ile Asp 
    50                  55                  60                  


Lys Ser Leu Ser Asn Ile Glu Leu Asn Gly Ile Asp Arg Tyr Tyr Glu 
65                  70                  75                  80  


Leu Tyr Ser Ile Asn Asn Arg Asp Asp Lys Gln Lys Glu Glu Leu Asp 
                85                  90                  95      


Gln Leu Glu Ala Ser Leu Arg Lys Gln Ile Ser Asp Ala Phe Lys Lys 
            100                 105                 110         


Ser Ala Glu Tyr Lys Gly Leu Phe Gln Lys Asp Ile Ile Thr Ser Tyr 
        115                 120                 125             


Leu Val Thr Met Tyr Lys Glu Asn Gln Glu Lys Met Gln Asp Ile Gly 
    130                 135                 140                 


Glu Phe Asn Arg Phe Thr Thr Tyr Phe Thr Gly Tyr Asn Lys Asn Arg 
145                 150                 155                 160 


Glu Asn Met Tyr Ser Glu Glu Asp Lys Ser Thr Ala Ile Ser Tyr Arg 
                165                 170                 175     


Leu Ile Asn Glu Asn Leu Pro Thr Phe Ile Asp Asn Ile Lys Ile Tyr 
            180                 185                 190         


Lys Lys Ile Val Ser Leu Met Pro Glu Asp Ile Glu Lys Ile Tyr Lys 
        195                 200                 205             


Asp Leu Glu Glu Tyr Ile Gln Val Asp Ser Ile Asp Glu Ile Phe Asn 
    210                 215                 220                 


Ile Ser Tyr Tyr Asn Asp Val Leu Thr Gln Arg Gly Ile Glu Cys Tyr 
225                 230                 235                 240 


Asn Ile Leu Ile Ser Gly Arg Thr Lys Asn Asp Gly Asp Lys Ile Lys 
                245                 250                 255     


Gly Leu Asn Glu Tyr Ile Asn Glu Phe Asn Gln Thr His Asn Glu Lys 
            260                 265                 270         


Ile Pro Lys Leu Gln Glu Leu Tyr Lys Gln Ile Leu Ser Asp Ala Glu 
        275                 280                 285             


Ser Ala Ser Phe Lys Ile Asp Val Ile Lys Asn Asp Lys Glu Leu Met 
    290                 295                 300                 


Asn Leu Ile Glu Val Tyr Tyr Ala Asn Ile Leu Pro Ile Leu Asn Lys 
305                 310                 315                 320 


Ile Glu Asp Leu Phe Thr Arg Ile Ser Asn Tyr Asn Leu Glu Leu Ile 
                325                 330                 335     


Leu Val Asn Asn Asp Gly Thr Leu Ser Thr Leu Ser Asn Met Val Phe 
            340                 345                 350         


Asn Glu Trp Ser Tyr Ile Lys Gly Ala Ile Ser Glu Lys Tyr Asp Glu 
        355                 360                 365             


Glu Tyr Ser Gly Lys Glu Lys Tyr Gly Thr Glu Lys Tyr Ala Gln Lys 
    370                 375                 380                 


Lys Gln Glu Tyr Leu Lys Lys Gln Lys Ile Tyr Ser Leu Lys Phe Leu 
385                 390                 395                 400 


Asn Asp Cys Ile Gly Asn Asn Ala Ile Cys Glu Tyr Leu Lys Asn Tyr 
                405                 410                 415     


Ile Ile Gln Asn Lys Asn Ile Glu Thr Ile Lys Glu Asp Tyr Asn Glu 
            420                 425                 430         


Val Gln Asn Ile Lys Val Glu Asp Asp Thr Lys Glu Leu Ile Lys Asp 
        435                 440                 445             


Glu Lys Ser Ile Glu Lys Ile Lys Lys Phe Leu Asp Asp Val Lys Ser 
    450                 455                 460                 


Leu Gln Glu Phe Val Lys Leu Val Ile Pro Lys Asp Arg Thr Val Glu 
465                 470                 475                 480 


Lys Asp Ala Lys Phe Tyr Ser Glu Leu Thr Pro Tyr Tyr Glu Lys Ile 
                485                 490                 495     


Lys Glu Ile Ile Pro Leu Tyr Asn Lys Val Arg Asn Tyr Val Thr Gln 
            500                 505                 510         


Lys Pro Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Glu Cys Pro Thr 
        515                 520                 525             


Leu Leu Lys Gly Trp Asp Ala Asn Lys Glu Glu Ala Asn Leu Gly Val 
    530                 535                 540                 


Ile Leu Leu Lys Glu Gly Lys Tyr Tyr Leu Gly Ile Ile Asn Pro Tyr 
545                 550                 555                 560 


Cys Lys Lys Ile Phe Glu Val Asp Glu Lys Asp Ser Asn Glu Gln Asn 
                565                 570                 575     


Asn Tyr Lys Lys Met Glu Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Asn Ser Arg Ile Glu Glu Phe Asn Pro 
        595                 600                 605             


Ser Lys Glu Leu Gln Glu Lys Tyr Asn Lys Gly Tyr His Lys Lys Gly 
    610                 615                 620                 


Lys Asp Phe Asp Ile Asn Phe Cys His Glu Leu Ile Asp Phe Tyr Lys 
625                 630                 635                 640 


Gln Ser Val Asn Lys His Glu Asp Trp Lys Lys Phe Asn Phe Lys Phe 
                645                 650                 655     


Lys Asp Thr Ser Glu Tyr Asn Asp Ile Ser Glu Phe Tyr Arg Glu Val 
            660                 665                 670         


Glu Lys Gln Gly Tyr Lys Ile Glu Tyr Thr Glu Tyr Ser Glu Lys Tyr 
        675                 680                 685             


Ile Asn Glu Leu Val Asp Arg Gly Glu Leu Tyr Leu Phe Gln Ile Tyr 
    690                 695                 700                 


Asn Lys Asp Phe Ser Glu Tyr Ser Lys Gly Lys Glu Asn Leu His Thr 
705                 710                 715                 720 


Leu Tyr Trp Lys Ala Val Phe Asp Pro Asp Asn Ile Met Asn Pro Val 
                725                 730                 735     


Tyr Lys Leu Asn Gly Asn Ala Glu Val Phe Tyr Arg Lys Lys Ser Leu 
            740                 745                 750         


Glu Met Lys Val Thr His Pro Ala Asn Gln Pro Ile Ala Asn Lys Asn 
        755                 760                 765             


Ile Ser Thr Ile Glu Ala Gly Arg Ser Thr Ser Thr Phe Lys Tyr Asp 
    770                 775                 780                 


Leu Ile Lys Asp Lys Arg Tyr Thr Met Asp Lys Phe Gln Phe His Val 
785                 790                 795                 800 


Pro Ile Thr Met Asn Phe Lys Ser Glu Arg Leu Phe Asn Ile Asn Gln 
                805                 810                 815     


Ile Val Asn Lys Tyr Leu Lys Tyr Asn Asp Asp Ile His Val Ile Gly 
            820                 825                 830         


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Val Cys Val Ile Asp Lys 
        835                 840                 845             


Asn Glu Lys Ile Val Tyr Gln Lys Ser Leu Asn Glu Ile Val Ser Glu 
    850                 855                 860                 


Tyr Asn Asn Asn Arg Tyr Thr Thr Asp Tyr His Gly Leu Leu Asp Arg 
865                 870                 875                 880 


Lys Glu Lys Glu Arg Glu Ile Ala Arg Glu Asp Trp Lys Asn Ile Glu 
                885                 890                 895     


Asn Ile Lys Glu Leu Lys Glu Gly Tyr Met Ser Gln Val Ile His Ile 
            900                 905                 910         


Leu Val Glu Leu Met Lys Lys Tyr Asn Ala Ile Ile Val Ile Glu Asp 
        915                 920                 925             


Leu Asn Lys Gly Phe Lys Asn Ser Arg Ile Lys Val Glu Lys Gln Val 
    930                 935                 940                 


Tyr Gln Lys Phe Glu Lys Met Phe Ile Asp Lys Leu Asn Tyr Leu Val 
945                 950                 955                 960 


Phe Lys Asp Glu Asp Lys Met Asn Glu Gly Gly Val Leu Asn Ala Tyr 
                965                 970                 975     


Gln Leu Thr Asn Lys Phe Glu Ser Phe Thr Lys Leu Gly Lys Gln Ser 
            980                 985                 990         


Gly Ile Leu Tyr Tyr Ile Pro Ala  Trp Cys Thr Ser Lys  Ile Asp Pro 
        995                 1000                 1005             


Thr Thr  Gly Phe Ile Asn Arg  Phe Tyr Leu Lys Tyr  Glu Asn Phe 
    1010                 1015                 1020             


Asp Lys  Ser Lys Glu Phe Val  Asn Arg Ile Asp Asp  Ile Arg Tyr 
    1025                 1030                 1035             


Asn Glu  Lys Glu Asn Leu Phe  Glu Phe Asp Ile Asp  Tyr Ser Lys 
    1040                 1045                 1050             


Phe Thr  Asp Arg Leu Asn Asp  Thr Lys Asn Lys Trp  Thr Leu Cys 
    1055                 1060                 1065             


Ser Tyr  Gly Glu Arg Ile Leu  Thr Gln Lys Asn Ala  Asn Gly Glu 
    1070                 1075                 1080             


Trp Leu  Asp Arg Arg Ile Gln  Leu Ser Ile Glu Phe  Lys Lys Leu 
    1085                 1090                 1095             


Phe Glu  Lys Tyr Gly Ile Asn  Leu Asn Asn Ile Lys  Asp Ser Ile 
    1100                 1105                 1110             


Leu Lys  Leu Asp Lys Asp Asn  Leu Glu Phe Tyr Lys  Gly Asn Gly 
    1115                 1120                 1125             


Glu Ser  Leu Gly Phe Ile Gln  Leu Phe Lys Leu Met  Val Gln Met 
    1130                 1135                 1140             


Arg Asn  Ser Leu Thr Gly Lys  Glu Glu Asp Asn Leu  Ile Ser Pro 
    1145                 1150                 1155             


Val Lys  Asn Gln His Gly Lys  Phe Phe Asn Thr Ser  Glu Lys Ile 
    1160                 1165                 1170             


Glu Gly  Leu Pro Ile Asp Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1175                 1180                 1185             


Ala Arg  Lys Gly Phe Met Leu  Val Glu Gln Met Lys  Asn Val Glu 
    1190                 1195                 1200             


Asp Glu  Lys Leu Asn Lys Ile  Lys Tyr Asn Ile Thr  Glu Lys Glu 
    1205                 1210                 1215             


Trp Leu  Asn Tyr Val Gln Asn  Arg Gly Met 
    1220                 1225             


<210> 558
<211> 1142
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 558
Met Ala Arg Ile Phe Glu Asp Phe Lys Arg Leu Tyr Pro Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Ala Lys Pro Ile Gly Ala Thr Leu Asp Asn Ile 
            20                  25                  30          


Val Lys Ser Gly Leu Leu Asp Glu Asp Glu His Arg Ala Glu Ser Tyr 
        35                  40                  45              


Val Lys Val Lys Lys Leu Ile Asp Glu Tyr His Lys Val Phe Ile Asp 
    50                  55                  60                  


Arg Val Leu Asp Asn Gly Cys Leu Pro Leu Lys Asn Glu Gly His Asn 
65                  70                  75                  80  


Asn Ser Leu Thr Glu Tyr Tyr Asp Ser Tyr Val Ser Lys Ser Gln Asn 
                85                  90                  95      


Glu Asp Ala Lys Lys Ala Phe Glu Glu Asn Gln Gln Asn Leu Arg Ser 
            100                 105                 110         


Ile Ile Ala Lys Lys Leu Thr Glu Asp Lys Ala Tyr Ala Asn Leu Phe 
        115                 120                 125             


Gly Lys Asn Leu Ile Glu Ser Tyr Lys Asp Lys Thr Asp Lys Thr Lys 
    130                 135                 140                 


Ile Ile Asp Ser Asp Leu Ile Gln Phe Ile Asn Thr Ala Glu Ser Thr 
145                 150                 155                 160 


Gln Leu Asn Ser Met Ser Gln Asp Glu Ala Lys Glu Leu Val Lys Glu 
                165                 170                 175     


Phe Trp Gly Phe Thr Thr Tyr Phe Val Gly Phe Phe Asp Asn Cys Lys 
            180                 185                 190         


Asn Met Tyr Thr Ala Glu Glu Lys Ser Thr Gly Ile Ala Tyr Arg Leu 
        195                 200                 205             


Ile Asn Glu Asn Leu Pro Lys Phe Ile Asp Asn Met Glu Ala Phe Lys 
    210                 215                 220                 


Lys Ala Ile Ala Arg Pro Glu Ile Gln Ala Asn Met Glu Glu Leu Tyr 
225                 230                 235                 240 


Ser Asn Phe Ser Glu Tyr Leu Asn Val Glu Ser Ile Gln Glu Met Phe 
                245                 250                 255     


Leu Leu Asp Tyr Tyr Asn Met Leu Leu Thr Gln Lys Gln Ile Asp Val 
            260                 265                 270         


Tyr Asn Ala Ile Ile Gly Gly Lys Thr Asp Asp Glu His Asp Val Lys 
        275                 280                 285             


Ile Lys Gly Ile Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Gln His Lys 
    290                 295                 300                 


Asp Asp Lys Leu Pro Lys Leu Lys Ala Leu Phe Lys Gln Ile Leu Ser 
305                 310                 315                 320 


Asp Arg Asn Ala Ile Ser Trp Leu Pro Glu Glu Phe Asn Ser Asp Gln 
                325                 330                 335     


Glu Val Leu Asn Ala Ile Lys Asp Cys Tyr Glu Arg Leu Ser Glu Asn 
            340                 345                 350         


Val Leu Gly Asp Lys Val Leu Lys Ser Leu Leu Gly Ser Leu Ala Asp 
        355                 360                 365             


Tyr Ser Leu Asp Gly Ile Phe Ile Arg Asn Asp Leu Gln Leu Thr Asp 
    370                 375                 380                 


Ile Ser Gln Lys Met Phe Gly Asn Trp Gly Val Ile Gln Asn Ala Ile 
385                 390                 395                 400 


Met Gln Asn Ile Lys Arg Val Ala Pro Ala Arg Lys His Lys Glu Ser 
                405                 410                 415     


Glu Glu Asp Tyr Glu Lys Arg Ile Ala Gly Ile Phe Lys Lys Ala Asp 
            420                 425                 430         


Ser Phe Ser Ile Ser Tyr Ile Asn Asp Cys Leu Asn Glu Ala Asp Pro 
        435                 440                 445             


Asn Asn Ala Tyr Phe Val Glu Asn Tyr Phe Ala Thr Phe Gly Ala Val 
    450                 455                 460                 


Asn Thr Pro Thr Met Gln Arg Glu Asn Leu Phe Ala Leu Val Gln Asn 
465                 470                 475                 480 


Ala Tyr Thr Glu Val Ala Ser Leu Leu His Ser Tyr Tyr Pro Ala Glu 
                485                 490                 495     


Lys Lys Leu Ala Gln Asp Lys Ala Asn Val Ala Lys Ile Lys Ala Leu 
            500                 505                 510         


Leu Asp Ala Ile Lys Ser Leu Gln His Phe Val Lys Pro Leu Leu Gly 
        515                 520                 525             


Lys Gly Asp Glu Ser Asp Lys Asp Glu Arg Phe Tyr Gly Glu Leu Ala 
    530                 535                 540                 


Ser Leu Trp Ala Glu Leu Asp Thr Val Thr Pro Leu Tyr Asn Met Ile 
545                 550                 555                 560 


Arg Asn Tyr Ile Thr Arg Lys Pro Tyr Ser Gln Lys Lys Ile Lys Leu 
                565                 570                 575     


Asn Phe Glu Asn Pro Gln Leu Leu Gly Gly Trp Asp Ala Asn Lys Glu 
            580                 585                 590         


Lys Asp Tyr Ala Thr Ile Ile Leu Arg Arg Asn Gly Leu Tyr Tyr Leu 
        595                 600                 605             


Ala Ile Met Asp Lys Asp Ser Arg Lys Leu Leu Gly Lys Ala Met Pro 
    610                 615                 620                 


Ser Asp Gly Glu Cys Tyr Glu Lys Met Val Tyr Lys Leu Leu Pro Gly 
625                 630                 635                 640 


Ala Asn Lys Met Leu Pro Lys Val Phe Phe Ala Lys Ser Arg Met Asp 
                645                 650                 655     


Asp Phe Lys Pro Ser Lys Glu Leu Ile Glu Lys Tyr Asn Asn Gly Thr 
            660                 665                 670         


His Lys Lys Gly Lys Asn Phe Asp Ile Gln Asp Cys His Asn Leu Ile 
        675                 680                 685             


Asp Tyr Phe Lys Gln Ser Ile Asp Lys His Glu Asp Trp Ser Lys Phe 
    690                 695                 700                 


Gly Phe Asn Phe Ser Asp Thr Ser Thr Tyr Glu Asp Leu Ser Gly Phe 
705                 710                 715                 720 


Tyr Arg Glu Val Glu Gln Gln Gly Tyr Lys Leu Ser Phe Ala Arg Val 
                725                 730                 735     


Ser Val Ser Tyr Ile Asn Gln Leu Val Glu Glu Gly Lys Met Tyr Leu 
            740                 745                 750         


Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Tyr Ser Lys Gly Thr Pro 
        755                 760                 765             


Asn Met His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn Leu 
    770                 775                 780                 


Ala Asp Val Val Tyr Lys Leu Asn Gly Gln Ala Glu Met Phe Tyr Arg 
785                 790                 795                 800 


Lys Lys Ser Ile Glu Asn Thr His Pro Thr His Pro Ala Asn His Pro 
                805                 810                 815     


Ile Leu Asn Lys Asn Lys Asp Asn Lys Lys Lys Glu Ser Leu Phe Glu 
            820                 825                 830         


Tyr Asp Leu Ile Lys Asp Arg Arg Tyr Thr Val Asp Lys Phe Met Phe 
        835                 840                 845             


His Val Pro Ile Thr Met Asn Phe Lys Ser Val Gly Ser Glu Asn Ile 
    850                 855                 860                 


Asn Gln Gly Val Lys Glu Tyr Leu His His Ala Asp Asp Met His Ile 
865                 870                 875                 880 


Ile Gly Ile Asp Arg Gly Glu Arg His Leu Leu Tyr Leu Val Val Ile 
                885                 890                 895     


Asp Leu Gln Gly Asn Ile Lys Glu Gln Tyr Ser Leu Asn Glu Ile Val 
            900                 905                 910         


Asn Glu Tyr Asn Gly Asn Thr Tyr His Thr Asn Tyr His Asp Leu Leu 
        915                 920                 925             


Asp Ala Arg Glu Asp Glu Arg Leu Lys Ala Arg Gln Ser Trp Gln Thr 
    930                 935                 940                 


Ile Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Leu Ser Gln Val Ile 
945                 950                 955                 960 


His Lys Ile Thr Gln Leu Met Val Lys Tyr His Ala Ile Val Val Leu 
                965                 970                 975     


Glu Asp Leu Asn Met Gly Phe Met Arg Gly Arg Gln Lys Val Glu Lys 
            980                 985                 990         


Gln Val Tyr Gln Lys Phe Glu Lys  Met Leu Ile Asp Lys  Leu Asn Tyr 
        995                 1000                 1005             


Leu Val  Asp Lys Lys Ala Asp  Ala Ser Val Ser Gly  Gly Leu Leu 
    1010                 1015                 1020             


Asn Ala  Tyr Gln Leu Thr Ser  Lys Phe Asp Ser Phe  Gln Lys Leu 
    1025                 1030                 1035             


Gly Lys  Gln Ser Gly Phe Leu  Phe Tyr Ile Pro Ala  Trp Asn Thr 
    1040                 1045                 1050             


Ser Lys  Ile Asp Pro Val Thr  Gly Phe Val Asn Leu  Leu Asp Ala 
    1055                 1060                 1065             


Arg Tyr  Gln Asn Val Glu Lys  Ala Lys Ala Phe Phe  Ser Lys Phe 
    1070                 1075                 1080             


Asp Ala  Ile Arg Tyr Lys Arg  Ile Arg Thr Gly Leu  Ser Leu Ile 
    1085                 1090                 1095             


Ser Thr  Met Thr Ser Leu Val  Lys Lys Gln Lys Val  Gln Gly Leu 
    1100                 1105                 1110             


Ser Gly  Phe Tyr Ala Pro Glu  Glu Cys Val Leu Ile  Leu Ser Glu 
    1115                 1120                 1125             


Ile Lys  Lys Lys Thr His Asn  Gly Ile Ile Arg Lys  Leu Thr 
    1130                 1135                 1140         


<210> 559
<211> 1250
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 559
Met Ile Ser Leu Asn Tyr Phe Gln Asn Gln Tyr Ala Val Ala Lys Thr 
1               5                   10                  15      


Leu Cys Leu Glu Leu Arg Pro Ile Glu Lys Thr Met Glu Tyr Ile Ile 
            20                  25                  30          


Ser Ser Gly Ile Leu Lys Glu Asp Glu His Arg Asn Glu Ser Tyr Lys 
        35                  40                  45              


Leu Val Lys Lys Ile Ile Asp Asp Tyr His Lys Ala Tyr Ile Glu Leu 
    50                  55                  60                  


Ser Leu Ser Arg Phe Glu Leu Lys Ile Thr Ser Cys Ser Lys Asn Asp 
65                  70                  75                  80  


Ala Leu Glu Asp Phe Tyr Cys Gln Tyr Leu Ala Asn Ser Gln Glu Glu 
                85                  90                  95      


Lys Asp Lys Asn Ile Phe Lys Lys Thr Gln Asp Asn Leu Arg Lys Gln 
            100                 105                 110         


Ile Ala Lys His Leu Thr Gln Gly Glu Ala Tyr Lys Arg Ile Asp Lys 
        115                 120                 125             


Lys Glu Leu Ile Gln Glu Asp Leu Leu Glu Phe Val Ala Ala Asp Pro 
    130                 135                 140                 


Asp Ala Ala Asn Lys Lys Ile Leu Ile Asn Glu Phe Arg Asp Phe Thr 
145                 150                 155                 160 


Thr Tyr Phe Thr Gly Phe Tyr Glu Asn Arg Lys Asn Met Tyr Ser Glu 
                165                 170                 175     


Glu Ala Gln Ser Thr Ala Ile Ala Tyr Arg Ile Ile His Glu Asn Leu 
            180                 185                 190         


Pro Lys Phe Ile Asp Asn Met Gly Thr Phe Lys Gln Leu Met Gln Ser 
        195                 200                 205             


Ser Ile Thr Asp Ile Leu Pro Gln Ile Phe Asp Asn Phe Lys Lys Asp 
    210                 215                 220                 


Leu Glu Val Ser Ser Ile Gln Glu Ile Phe Asp Leu Asn Tyr Phe Asn 
225                 230                 235                 240 


Lys Val Leu Thr Gln Lys Gln Ile Asp Ile Tyr Asn Ala Ile Ile Gly 
                245                 250                 255     


Gly Lys Ser Leu Asn Glu Asn Ser Arg Ile Gln Gly Leu Asn Glu Tyr 
            260                 265                 270         


Ile Asn Leu Tyr Asn Gln Gln His Lys Glu Asn Lys Leu Pro Leu Leu 
        275                 280                 285             


Lys Leu Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Ser Leu Ser Trp 
    290                 295                 300                 


Leu Pro Glu Ala Phe Glu Thr Asp Lys Gln Val Leu His Ala Val Arg 
305                 310                 315                 320 


Lys Cys Tyr Ala Asn Leu Lys Glu Ser Val Leu His Glu Ala Gly Leu 
                325                 330                 335     


Val Gln Leu Leu Ser Ser Leu Pro Ser Tyr Asp Ser Thr Arg Ile Tyr 
            340                 345                 350         


Ile Arg Asn Asp Gln Ala Leu Thr Thr Ile Ser Gln Lys Leu Phe Gly 
        355                 360                 365             


Asp Trp Gly Ile Ile Pro His Ala Ile Lys Glu Arg Leu Lys Lys Asp 
    370                 375                 380                 


Ile Ser Ala Lys Arg Lys Glu Thr Glu Glu Ala Tyr Leu Glu Arg Ile 
385                 390                 395                 400 


Glu Lys Ala Phe Lys Gln Ala Asp Ser Tyr Thr Ile Ala Tyr Ile Asn 
                405                 410                 415     


Asp Ser Leu Lys Glu Ile Gly Val Asp Lys Lys Asn Ile Glu Asp Tyr 
            420                 425                 430         


Phe Ile His Leu Gly Ala Ile Cys Thr Glu Gly Gln Glu Gln Glu Asn 
        435                 440                 445             


Ile Leu Gln Arg Ile Ala Ser Ala Tyr Ser Gln Ala Gln Pro Leu Leu 
    450                 455                 460                 


Glu Glu Lys Val Pro Val His Lys Asn Leu Met Gln Asp Lys Asp Ser 
465                 470                 475                 480 


Val Glu Leu Ile Lys Ser Leu Leu Asp Glu Leu Lys Asn Leu Gln His 
                485                 490                 495     


Phe Ile Lys Pro Leu Leu Gly Lys Gly Ser Glu Ser Asp Lys Asp Glu 
            500                 505                 510         


Arg Phe Tyr Gly Glu Phe Val Gly Leu Trp Asn Glu Leu Asp Gln Ile 
        515                 520                 525             


Thr Thr Leu Tyr Asn Lys Val Arg Asn Tyr Val Thr Arg Lys Pro Tyr 
    530                 535                 540                 


Ser Ile Glu Lys Phe Lys Ile Asn Phe Gln Asn Ala Thr Leu Leu Lys 
545                 550                 555                 560 


Gly Trp Asp Arg Asn Lys Glu Arg Asp Asn Thr Ser Ile Ile Leu Arg 
                565                 570                 575     


Lys Asn Gly Leu Tyr Tyr Leu Ala Ile Met Arg Lys Glu Tyr Asn Lys 
            580                 585                 590         


Val Phe Glu Lys Tyr Pro Ala Gly Thr Glu Glu Asn Cys Tyr Glu Lys 
        595                 600                 605             


Met Glu Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
    610                 615                 620                 


Phe Phe Ser Lys Ser Arg Ile Asn Glu Phe Asn Pro Ser Pro Gln Leu 
625                 630                 635                 640 


Leu Gln Asn Tyr Gln Met Gly Thr His Lys Lys Gly Asp Gln Phe Lys 
                645                 650                 655     


Lys Glu Asp Cys His Ala Leu Ile Asp Phe Phe Lys Thr Ser Ile Glu 
            660                 665                 670         


Lys His Glu Asp Trp Lys Asn Phe Asn Phe Gln Phe Ser Pro Thr Ser 
        675                 680                 685             


Val Tyr Glu Asp Met Ser Gly Phe Tyr Arg Glu Val Glu Gln Gln Gly 
    690                 695                 700                 


Tyr Lys Leu Val Phe Arg Ser Ile Asp Ala Glu Tyr Ile Asp Lys Leu 
705                 710                 715                 720 


Val Glu Glu Gly Lys Ile Phe Leu Phe Gln Ile Tyr Asn Lys Asp Phe 
                725                 730                 735     


Ser Pro Phe Ser Lys Gly Thr Pro Asn Leu His Thr Leu Tyr Trp Lys 
            740                 745                 750         


Met Leu Phe Asp Glu Arg Asn Leu Asn Asn Val Val Tyr Lys Leu Asn 
        755                 760                 765             


Gly Glu Ala Glu Ile Phe Phe Arg Lys Lys Ser Ile Thr Tyr Thr His 
    770                 775                 780                 


Pro Thr His Pro Ala Glu Ile Pro Ile Lys Asn Lys Asn Val Gln Asn 
785                 790                 795                 800 


Lys Lys Lys Glu Ser Val Phe Gln Tyr Asp Leu Ile Lys Asn His Arg 
                805                 810                 815     


Phe Thr Ile Asp Ser Phe Gln Phe His Val Pro Ile Thr Met Asn Phe 
            820                 825                 830         


Lys Asn Ala Gly Leu Ser Asn Leu Asn Glu Gln Val Tyr Thr Tyr Leu 
        835                 840                 845             


Arg Glu Asn Lys Asp Ala His Ile Ile Gly Ile Asp Arg Gly Glu Arg 
    850                 855                 860                 


His Leu Leu Tyr Leu Val Val Ile Asp Arg Tyr Gly Arg Ile Val Lys 
865                 870                 875                 880 


Gln Phe Ser Leu Asn Glu Ile Val Asn Glu Tyr His Gly Asn Thr Tyr 
                885                 890                 895     


Thr Thr Asn Tyr His Asp Leu Leu Asp Lys Arg Glu Glu Ala Arg Gln 
            900                 905                 910         


Gln Ala Arg Gln Ser Trp Gln Ser Ile Glu Asn Ile Lys Glu Leu Lys 
        915                 920                 925             


Glu Gly Tyr Leu Ser Gln Val Val His Lys Ile Ala Asn Leu Met Val 
    930                 935                 940                 


Glu Tyr His Ala Ile Val Val Leu Glu Asp Leu Asn Ile Gly Phe Met 
945                 950                 955                 960 


Arg Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys 
                965                 970                 975     


Met Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Lys Lys Ala Pro 
            980                 985                 990         


Glu Ala Asp Gly Gly Leu Leu Lys  Ala Phe Gln Leu Thr  Asn Gln Phe 
        995                 1000                 1005             


Glu Ser  Phe Gln Lys Leu Gly  Lys Gln Ser Gly Phe  Leu Phe Tyr 
    1010                 1015                 1020             


Val Pro  Ala Trp Asn Thr Ser  Lys Ile Asp Pro Cys  Thr Gly Phe 
    1025                 1030                 1035             


Thr Asn  Leu Leu Asp Thr Arg  Tyr Glu Asn Ile Ala  Lys Ala Gln 
    1040                 1045                 1050             


Lys Phe  Phe Arg Thr Phe Asp  Ala Ile Arg Tyr Asn  Ala Val Lys 
    1055                 1060                 1065             


Asp Tyr  Phe Glu Leu Glu Leu  Asp Tyr Asp Lys Phe  His Lys Arg 
    1070                 1075                 1080             


Ala Glu  Gly Thr Gln Thr Lys  Trp Thr Leu Cys Thr  Tyr Gly Thr 
    1085                 1090                 1095             


Arg Ile  Lys Thr Phe Arg Asn  Pro Glu Asn Asn Asn  Gln Trp Asp 
    1100                 1105                 1110             


Asn Val  Glu Ile Asn Leu Thr  Glu Glu Phe Lys Lys  Leu Phe Lys 
    1115                 1120                 1125             


Gln Phe  Gly Ile Asn Leu Ser  Gly Asp Leu Gln Gln  Ala Ile Cys 
    1130                 1135                 1140             


Ala Gln  Thr Glu Lys Ser Phe  Phe Glu Ser Leu Leu  Arg Leu Leu 
    1145                 1150                 1155             


Lys Leu  Thr Leu Gln Met Arg  Asn Ser Ile Thr Gly  Thr Asp Val 
    1160                 1165                 1170             


Asp Tyr  Leu Leu Ser Pro Val  Gln Asn Ala Glu Gly  Tyr Phe Tyr 
    1175                 1180                 1185             


Asp Ser  Arg Lys Gly Asp Lys  Ser Leu Pro Ala Asn  Ala Asp Ala 
    1190                 1195                 1200             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Gly Leu Trp  Val Ile Gln 
    1205                 1210                 1215             


Gln Ile  Lys Gln Thr Pro Gln  Gly Gln Lys Ala Lys  Leu Ser Ile 
    1220                 1225                 1230             


Ser Asn  Lys Glu Trp Leu Lys  Phe Ala Gln Glu Lys  Pro Tyr Leu 
    1235                 1240                 1245             


Lys Asp  
    1250 


<210> 560
<211> 1193
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 560
Met Lys Thr Phe Glu Asn Phe Thr Asn Leu Tyr Ser Leu Pro Arg Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Leu Tyr Lys Thr Lys Glu Leu Ile Asp 
            20                  25                  30          


Ser Lys Gln Glu Leu Phe Pro Lys Asp Lys Arg Ile Asp Glu Ile Tyr 
        35                  40                  45              


Gln Asn Ile Ile Lys Pro Cys Leu Asn Glu Leu His Ser Asp Phe Ile 
    50                  55                  60                  


Glu Lys Ser Met Glu Asn Lys Asp Phe Gln Asn Ile Pro Asp Asn Ile 
65                  70                  75                  80  


Leu Lys Ile Tyr Ser Asn Glu Lys Asn Ile Asp Asp Phe Lys Asn Ile 
                85                  90                  95      


Glu Lys Asp Leu Ile Lys Gln Ile Asn Trp Phe Leu Lys Ser Asn Lys 
            100                 105                 110         


Thr Phe Phe Ala Glu Asn Tyr Ser Asp Leu Leu Gly Lys Asn Ser Ile 
        115                 120                 125             


Asp Ile Ile Ile Lys Val Phe Trp Glu Lys Ile Tyr Lys Lys Asp Asp 
    130                 135                 140                 


Ser Trp Lys Ile Phe Leu Tyr Asn Asp Leu Leu Trp Lys Ser Tyr Glu 
145                 150                 155                 160 


Glu Leu Ile Asn Ile Tyr Phe Lys Trp Phe Ser Thr Tyr Leu Ser Asn 
                165                 170                 175     


Phe Asn Lys Asn Arg Glu Asn Leu Tyr Asp Lys Lys Asn Glu Ala Lys 
            180                 185                 190         


Val Trp Ser Val Ser Gly Arg Thr Ile Trp Glu Asn Phe Pro Arg Phe 
        195                 200                 205             


Leu Gln Asn Cys Ile Asn Phe Arg Asp Lys Leu Glu Lys Leu Asn Leu 
    210                 215                 220                 


Ser Ile Glu Gln Lys Asp Ile Phe Ile Thr Asn Asn Phe Trp Lys Cys 
225                 230                 235                 240 


Ile Ser Gln Lys Gln Ile Asp Tyr Tyr Asn Lys Ile Ile Trp Gln Ile 
                245                 250                 255     


Asn Ser Lys Thr Asn Glu Phe Asn Gln Lys Asn Gly Leu Lys Trp Asn 
            260                 265                 270         


Lys Lys Leu Pro Lys Leu Leu Leu Leu His Lys Gln Ile Leu Trp Lys 
        275                 280                 285             


Ser Glu Asn Glu Asn Ile Leu Asn Phe Ile Asn Asn Ile Ile Gln Thr 
    290                 295                 300                 


Asp Phe Glu Leu Glu Gln Glu Ile Lys Ile Ile Asn Lys Asp Ile Phe 
305                 310                 315                 320 


Gln Arg Ile Asp Phe Ile Lys Lys Ser Ile Val Ser Asn Ile Glu Asp 
                325                 330                 335     


Phe Glu Leu Glu Lys Ile Phe Ile Lys Lys Asn Arg Leu Lys Asp Ile 
            340                 345                 350         


Ser Ser Leu Leu Met Asp Asn Tyr Ser Val Leu Glu Lys Leu Leu Pro 
        355                 360                 365             


Glu Phe Asn Glu Glu Trp Lys Ile Ile Lys Glu Asn Glu Leu Val Asn 
    370                 375                 380                 


Leu Ser Lys Ile Lys Lys Ser Phe Glu Asn Ile Asp Leu Lys Asp Leu 
385                 390                 395                 400 


Lys Asn Ile Phe Lys Lys Glu Tyr Phe Asp Glu Ser Lys Asp Trp Phe 
                405                 410                 415     


Lys Leu Phe Leu Asn Trp Ile Tyr Asn His Phe Ser Asp Leu Glu Asn 
            420                 425                 430         


Asn Ile Lys His Thr His Lys Leu Val Gln Asp Lys Leu Ile Ser Trp 
        435                 440                 445             


Asn Phe Ser Glu Asn Ile Gln Lys Ser Glu Lys Asn Ile Asn Leu Arg 
    450                 455                 460                 


Asp Glu Ile Phe Val Ser Ser Lys Trp Leu Leu Lys Ala Tyr Leu Asp 
465                 470                 475                 480 


Ser Ile Leu Ala Leu Asp Arg Phe Val His Met Phe Asp Tyr Trp Glu 
                485                 490                 495     


Gln Lys Asp Phe Asp Ser Asn Phe Tyr Asn Asn Ile Glu Glu Tyr Ser 
            500                 505                 510         


Ile Asn Phe Ser Pro Phe Lys Thr Tyr Asn Ala Val Arg Asn Tyr Leu 
        515                 520                 525             


Thr Lys Lys Asn Tyr Ser Thr Asp Lys Ile Lys Leu Asn Phe Asp Tyr 
    530                 535                 540                 


Pro Asp Phe Leu Gly Ser Asn Ser Leu Trp Lys Tyr Ala Phe Ile Tyr 
545                 550                 555                 560 


Lys Asp Ser Lys Trp Phe Tyr Tyr Leu Trp Val Leu Asp His Ser Asn 
                565                 570                 575     


Ser Gln Ser Lys Tyr Lys Pro Gln Ile Leu Lys Asn Asn Thr Glu Phe 
            580                 585                 590         


Tyr Gln Leu Glu Tyr Lys Gln Ile Lys Phe Asn Thr Leu Ala Trp Lys 
        595                 600                 605             


Trp Tyr Ile Arg Asp Phe Trp Val Lys Tyr Ser Glu Asp Glu Asn Cys 
    610                 615                 620                 


Ile Ile Asn Leu Lys Thr Leu Ile Lys Lys Gln Tyr Leu Glu Arg Tyr 
625                 630                 635                 640 


Pro Val Leu Lys Glu Ile Val Asp Phe Gln Thr Asp Asp Lys Lys Ile 
                645                 650                 655     


Phe Asp Ala Lys Val Lys Thr Ile Leu Glu Gln Ala Tyr Ser Ile Asn 
            660                 665                 670         


Phe Val Asn Ile Asp Lys Asn Tyr Ile Leu Glu Glu Asn Asn Asn Trp 
        675                 680                 685             


Asn Leu His Phe Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Asn Lys 
    690                 695                 700                 


Lys Ile Asn Ser Met Glu Asn Leu His Thr Met Tyr Phe Lys Ala Leu 
705                 710                 715                 720 


Phe Glu Lys Glu Asn Phe Asn Trp Trp Ala Cys Phe Lys Leu Asn Ser 
                725                 730                 735     


Gln Trp Ala Glu Ile Phe Phe Arg Glu Lys Ser Ile Asn Glu Lys Lys 
            740                 745                 750         


Val Lys Asp Leu Lys Thr Arg Asn Glu Asn Ala Ile Glu Lys Lys Arg 
        755                 760                 765             


Tyr Thr Glu Asn Lys Val Phe Leu His Leu Pro Ile Thr Leu Asn Phe 
    770                 775                 780                 


Ile Asn Lys Trp Tyr Ser Lys Tyr Ser Phe Trp Tyr Ile Asn Asp Ser 
785                 790                 795                 800 


Val Lys Lys Tyr Ile Lys Glu Asn Lys Ile Ser Ile Ile Trp Ile Asp 
                805                 810                 815     


Arg Trp Glu Lys Asn Leu Ile Tyr Phe Ser Met Ile Asn Glu Asn Leu 
            820                 825                 830         


Glu Ile Ile Glu Leu Lys Ser Leu Asn Ser Leu Ile Leu Lys Val Ser 
        835                 840                 845             


Asp Leu Glu Glu Lys Glu Val Asn Tyr Phe Glu Lys Leu Ser Lys Lys 
    850                 855                 860                 


Glu Trp Asn Arg Asn Lys Glu Arg Lys Asp Trp Asp Glu Ile Glu Thr 
865                 870                 875                 880 


Ile Lys Glu Leu Lys Glu Trp Tyr Ile Ser Gln Ile Val Asp Asn Leu 
                885                 890                 895     


Val Lys Leu Ile Val Lys His Asn Ala Ile Val Val Met Glu Asp Leu 
            900                 905                 910         


Asn Ser Gly Phe Lys Arg Trp Arg Gln Lys Ile Glu Lys Gln Ile Tyr 
        915                 920                 925             


Gln Lys Phe Glu Leu Ala Leu Ala Lys Lys Leu Asn Phe Thr Val Asp 
    930                 935                 940                 


Lys Asn Lys Lys His Asp Glu Leu Trp Trp Ile Tyr Lys Ala Tyr Gln 
945                 950                 955                 960 


Leu Thr Pro Gln Ile Glu Asn Phe Gln Asp Ile Tyr Ser Gln Thr Trp 
                965                 970                 975     


Ile Ile Phe Tyr Thr Gln Ala Ala Tyr Thr Ser Val Thr Cys Pro Asn 
            980                 985                 990         


Cys Ser Phe Arg Lys Asn Ile Tyr  Gln Lys Tyr Glu Asn  Glu Ser Lys 
        995                 1000                 1005             


Phe Lys  Glu Phe Phe Lys Lys  Tyr Ile Leu Glu Ile  Lys Phe Glu 
    1010                 1015                 1020             


Asp Asn  Cys Phe Ile Ile Lys  Tyr Lys Ile Asp Glu  Lys Ile Asp 
    1025                 1030                 1035             


Lys Lys  Lys Asn Lys Leu Lys  Lys Leu Glu Phe Gln  Val Asn Thr 
    1040                 1045                 1050             


Lys Asn  Gln Ile Arg Leu Lys  Phe Glu Lys Ser Leu  Lys Trp Lys 
    1055                 1060                 1065             


Trp Trp  Glu Thr Lys Glu Phe  Asn Ile Thr Glu Lys  Phe Lys Glu 
    1070                 1075                 1080             


Ile Phe  Glu Lys His Lys Leu  Asp Leu Trp Asn Leu  Lys Glu Glu 
    1085                 1090                 1095             


Leu Leu  Ala Trp Asn Trp Glu  Ile Gln Leu Tyr Lys  Asp Phe Met 
    1100                 1105                 1110             


Phe Tyr  Phe Asn Leu Leu Leu  Gln Leu Arg Asn Ser  Lys Glu Asn 
    1115                 1120                 1125             


Asp Asn  Trp Trp Tyr Ile Ser  Cys Pro Ser Cys Trp  Phe His Ser 
    1130                 1135                 1140             


Gly Asn  Trp Phe Gln Trp Phe  Ser Tyr Asn Trp Asp  Ala Asn Trp 
    1145                 1150                 1155             


Ala Tyr  Asn Ile Ala Arg Lys  Trp Arg Ile Ile Leu  Asp Lys Ile 
    1160                 1165                 1170             


Lys Lys  Asp Glu Lys Asn Leu  Trp Ile Thr Asn Val  Glu Trp Asp 
    1175                 1180                 1185             


Asn Tyr  Tyr Gln Lys 
    1190             


<210> 561
<211> 1202
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 561
Met Ala Val Arg Ser Val Lys Leu Lys Leu Leu Val Pro Arg Asp Gly 
1               5                   10                  15      


Ser Ala Glu Ser Val Arg Lys Arg Lys Ala Leu Trp Ala Thr His Gln 
            20                  25                  30          


Phe Val Asn Asp Ala Ala Ala Ala Tyr Ala Glu Leu Leu Leu Glu Met 
        35                  40                  45              


Arg Gln Glu Asp Val Cys Arg Gly Thr Asp Asp His Gly Lys Asp Val 
    50                  55                  60                  


Ile Glu Pro Ala Ala His Trp Gln Ala Lys Leu Arg Ala Arg Leu Ala 
65                  70                  75                  80  


Ala Lys Gln Leu Pro Pro Val Ala Val Ala Glu Ala Leu Pro Leu Leu 
                85                  90                  95      


Lys Ala Phe Tyr Gly Ser Arg Leu Ile Lys Ser Phe Val Ala Asn Asp 
            100                 105                 110         


Lys Gly Val Ala Gly Thr Gly Asn Ala Thr Asp Leu Asn Thr Trp Leu 
        115                 120                 125             


Ser Gly Leu Val Asp Pro Ala Ser Val Ala Gly Glu Lys Thr Glu Leu 
    130                 135                 140                 


Arg Lys Gln Leu Leu Ala Glu Leu Pro Leu Cys Glu Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Phe Glu Gly Ala Ala Arg Lys Met Leu Ala Lys Ser Asp Ala Arg 
                165                 170                 175     


Glu Ala Leu Leu Glu Gly Pro Gly Thr Gly Val Gly Trp Pro Ala Ala 
            180                 185                 190         


Tyr Asn Ala Asn Pro Thr Asp Ser Val Trp Leu Asp Met Leu His Lys 
        195                 200                 205             


Ala Ala Ala Lys Ala Arg Leu Glu Leu Ala Asp Thr Thr Val Ser Glu 
    210                 215                 220                 


Leu Lys Lys Leu Gly Val Phe Pro Leu Leu Gln Ala Ala Ser Ser Asn 
225                 230                 235                 240 


Arg Val Phe Gly Ser Gly Val Leu Asn Pro Phe Glu Arg Met Ala Ala 
                245                 250                 255     


Ala Gln Ala Ala Ala Ala Leu Leu Pro Trp Glu Thr Lys Arg His Glu 
            260                 265                 270         


Met Arg Lys Arg Arg Asp Lys Phe Ala Asp Gln Leu Asn Gln Trp Asp 
        275                 280                 285             


Thr Glu Phe Gly Ala Ser His Ala Thr Ala Leu Ala Ala Ile Arg Ala 
    290                 295                 300                 


Phe Glu Ala Glu Glu Ser Glu Arg Ala Arg Arg Glu Ser Leu Gly Asn 
305                 310                 315                 320 


Glu Gly Thr Gly Tyr Arg Ile Gly Gly Arg Glu Leu Arg Asp Ala Trp 
                325                 330                 335     


Thr Leu Leu Arg Asp Trp Leu Lys Gly His Ser Thr Ala Thr Ala Ala 
            340                 345                 350         


Ala Arg Glu Asp Lys Val Arg Glu Leu Gln Ala Lys Gln Gly Arg Ser 
        355                 360                 365             


Phe Gly Ser His Arg Leu Leu Ser Trp Leu Ala Lys Pro Ala Gln Gln 
    370                 375                 380                 


Trp Leu Ala Asp His Ser Ala Gly Asp Val Val Thr Arg Ile Ala Val 
385                 390                 395                 400 


Arg Asn Ala Arg Gln Arg Lys Leu Asp Thr Ala Arg Thr Leu Pro Ile 
                405                 410                 415     


Trp Thr Gly Ala Asp Ala Val Lys His Pro Arg Phe Ala Asn Phe Asp 
            420                 425                 430         


Pro Pro Asn Asn Thr Asn Gln Pro Gly Phe Asp Leu Arg Ala Gly Thr 
        435                 440                 445             


Gln Lys Gly Arg Leu Thr Leu Arg Leu Ser Leu Leu Thr Glu Arg Ala 
    450                 455                 460                 


Asp Gly Leu Leu Leu Ala Gln Asp His Asp Phe Gln Leu Val Pro Ser 
465                 470                 475                 480 


Arg Gln Met Ala Glu Ile Val Leu His Lys Asp Gly Lys Glu Arg Ala 
                485                 490                 495     


Leu Ser Trp Gln Ser Gln Asp Gly Ile Gly Arg Gln Val Gly Asp Val 
            500                 505                 510         


Gly Gly Ser Ala Leu Leu Phe Ser Arg Asp His Ala Glu Cys Leu Leu 
        515                 520                 525             


Glu Arg Lys Gln Ile Thr Arg Leu Glu Arg Gly Ala Trp Pro Ala Ala 
    530                 535                 540                 


Leu Pro Val Trp Phe Lys Leu Ser Leu Asp Ile Gly Ala Glu His Lys 
545                 550                 555                 560 


Ala Leu Leu Lys Gln Arg Phe Lys Trp Gly Val Trp Leu Asn Ser Ala 
                565                 570                 575     


Leu Val Thr Arg Asn Ala Lys Asp Ala Lys Gly Val Pro Pro Pro Val 
            580                 585                 590         


Gly Thr Arg Val Leu Ala Val Asp Leu Gly Leu Arg Ser Ala Ala Thr 
        595                 600                 605             


Val Ser Val Trp Gln Val Val Asp Ala Ala Thr Pro Val Val Ala Gly 
    610                 615                 620                 


Lys Trp Arg Val Pro Leu Ser Asp Thr Leu Ser Ala Val His Glu Arg 
625                 630                 635                 640 


Ser Ala Met Leu Ala Leu Pro Gly Glu His Val Asp Ala Gly Val Leu 
                645                 650                 655     


Ala Ala Arg Arg Ala Ala Asn Glu Lys Leu Ala Gly Leu Leu Ala Ala 
            660                 665                 670         


Thr Ser His Leu Ser Thr Val Phe Lys Leu Gly Arg Ala Glu Gln Gly 
        675                 680                 685             


Asp Arg Arg Arg Glu Leu Leu Glu Arg Leu Gly Glu Gly Asp Asp Arg 
    690                 695                 700                 


Arg Ala Arg Ala Ala Val Ala Thr Thr Ala Ala Glu Arg Asp Gly Leu 
705                 710                 715                 720 


Arg Ala Val Leu Gly Ala Thr Gln Asp Ala Trp Ala Gly Ala Val Ala 
                725                 730                 735     


Ala Val Trp Arg Arg Leu Glu Thr Asp Leu Ala Gly Ala Ile Ala Ala 
            740                 745                 750         


Tyr Arg Lys Gln Gln Arg Glu Asp Val Gln Leu Arg Arg Glu Ala Arg 
        755                 760                 765             


His Gly Pro Gly Ala Ser Gln Leu Pro Lys Gln Ala Ala Ala Glu Arg 
    770                 775                 780                 


Leu Leu Gly Gly Lys Ser Ala Trp Gln Ile Glu Tyr Lys Glu Arg Val 
785                 790                 795                 800 


Arg Lys Leu Leu Thr Arg Trp Ile Met Arg Gln Arg Pro Gly Asp Thr 
                805                 810                 815     


Ala Val Arg Arg Leu Ala Arg Lys Asp Leu Gly Lys Tyr Cys Gly Gly 
            820                 825                 830         


Leu Leu Asp His Leu Thr Ala Leu Lys Glu Asp Arg Ala Lys Thr Thr 
        835                 840                 845             


Ala Asp Leu Ile Val Gln Ala Ala Arg Gly Arg Val Arg Ala His Lys 
    850                 855                 860                 


Asp Ala His Gly Arg Gln Gln Asp Arg Glu Leu Trp Leu Ala Lys Tyr 
865                 870                 875                 880 


Ala Pro Cys Asp Leu Ile Val Met Glu Asp Leu Gly Arg Tyr Arg Phe 
                885                 890                 895     


Ala Thr Asp Arg Pro Pro Ser Glu Asn Arg Gln Leu Met Gln Trp Thr 
            900                 905                 910         


His Arg Glu Val Phe Arg Leu Val Gln Met Gln Ala Glu Val Glu Gly 
        915                 920                 925             


Ile Gln Val Leu Glu Thr Gly Ala Glu Phe Ser Ser Lys Phe Asp Ala 
    930                 935                 940                 


Arg Thr Trp Ala Pro Gly Val Arg Cys Glu Pro Ile Thr Lys Leu Trp 
945                 950                 955                 960 


Val Glu Arg Tyr Arg Asn Gly Glu Met Pro Trp Leu Ala Asp Lys Ala 
                965                 970                 975     


Asp Glu Trp Arg Arg Glu Gly Ile Glu Leu Ala Gln Leu Val Pro Gly 
            980                 985                 990         


Gln Leu Leu Pro Thr Gly Ser Gly  Glu Gln Phe Val Ala  Val Ser Ala 
        995                 1000                 1005             


Thr Gly  Gly Leu Arg Val Arg  His Ala Asp Leu Asn  Ala Ala Gln 
    1010                 1015                 1020             


Cys Ile  Ala Leu Arg Ala Leu  Thr Gly His Gly Thr  Ala Phe Arg 
    1025                 1030                 1035             


Leu Thr  Ala Arg Arg Leu Gly  Asp Val Phe Val Ser  Ala Lys Gly 
    1040                 1045                 1050             


Leu Gly  Lys Arg Pro Gln Gly  Ala Leu Trp Arg Glu  Phe Gly Ser 
    1055                 1060                 1065             


Ala Leu  Pro Pro Ala Val Val  Val Leu Arg Pro Ala  Gly Glu Val 
    1070                 1075                 1080             


Arg Tyr  Ala Leu Arg Pro Phe  Ala Ser Ala Arg Asp  Ala Ala Ala 
    1085                 1090                 1095             


Ala Leu  Gly Leu Gln Leu Gly  Ala Leu Arg Asn Val  Asp Ala Thr 
    1100                 1105                 1110             


Asp Ala  Glu Ser Asp Ala Glu  Asp Gly Asp Leu Ala  Glu Leu Leu 
    1115                 1120                 1125             


Ala Gly  Ala Asp Pro Asp Arg  Ala Thr Phe Phe Arg  Asp Pro Ser 
    1130                 1135                 1140             


Gly Asp  Val His Gly Gly Ala  Trp Val Gln Ala Lys  Val Phe Trp 
    1145                 1150                 1155             


Ala Glu  Val Arg Arg His Val  Arg Leu Gly Leu Gln  Ala Gln Gly 
    1160                 1165                 1170             


Leu Leu  Pro Ala Ala Ala Arg  Ser Ser Glu Pro Arg  Gln Met Gln 
    1175                 1180                 1185             


Leu Pro  Leu Ala Gly Ala Leu  Pro Gly Asp Asp Ile  Pro Leu 
    1190                 1195                 1200         


<210> 562
<211> 669
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 562
Met Leu Asp Lys Phe Ala Ser Leu Tyr Pro Val Thr Lys Thr Leu Arg 
1               5                   10                  15      


Phe Arg Leu Leu Pro Gln Gly Arg Thr Glu Glu Asn Met Gln Val Ala 
            20                  25                  30          


Lys Val Leu Glu Asn Asp Leu Glu Arg Ser Glu Ala Ala Ala Val Val 
        35                  40                  45              


Lys Gly Leu Ile Lys Lys Tyr His Leu Gln Phe Ile Ser Asp Thr Leu 
    50                  55                  60                  


Ser Gly Ser Thr Leu Ser Trp Gln Ala Leu Thr Glu Thr Leu Asp Lys 
65                  70                  75                  80  


Phe Lys Ala Asp His Thr Ala Thr Ala Glu Leu Asp Ser Ala Leu Ala 
                85                  90                  95      


Ala Tyr Arg Cys Lys Leu Ala Glu Leu Phe Thr Lys Ser Pro Lys Tyr 
            100                 105                 110         


Lys Val Met Ala Thr Pro Val Ser Ile Ile Lys Glu Ile Leu Lys Thr 
        115                 120                 125             


Glu Thr Asp Pro Glu Asn Ile Ala Ala Leu Asn Lys Leu Asn Gly Tyr 
    130                 135                 140                 


Thr Tyr Ile Ile Phe Asp Tyr Val Ser Thr Arg Met Leu Thr Tyr Ser 
145                 150                 155                 160 


Ala Asp Ala Lys Ala Thr Ser Leu Ala Tyr Arg Leu Val Asp Glu Asn 
                165                 170                 175     


Tyr Leu Arg Phe Tyr Gln Asp Ile Ser Ala Ala Ala Glu Ile Ser Ala 
            180                 185                 190         


Val Leu Glu Glu Ala Gly Phe Asp Asn Ala Glu Val Glu Ala Phe Ile 
        195                 200                 205             


Arg Thr Asp Tyr Asn Thr Cys Leu Thr Ser Glu Gly Ile Ala Ser Phe 
    210                 215                 220                 


Asn Ala Ala Ala Gly Ser Ile Asn Gln Phe Val Asn Val Leu Leu Gln 
225                 230                 235                 240 


Gln Asn Pro Val Leu Gln Ser Glu Pro Ala Leu Arg Arg His Leu Gln 
                245                 250                 255     


Pro Leu Tyr Lys Met Leu Leu Asp Glu Ala Glu Ser Lys Ile Ile Lys 
            260                 265                 270         


Phe Glu Asp Tyr Gly Gln Leu Arg Asp Ala Val Glu Asn Phe Arg Arg 
        275                 280                 285             


Asn Phe Gln Asp Leu Pro Gln Ser Leu Ile Asp Ile Phe Ala Gly Arg 
    290                 295                 300                 


Tyr Asp Tyr Ser Lys Ile Tyr Val Gly Tyr Lys Tyr Leu Asn Glu Ala 
305                 310                 315                 320 


Ser Ser Gln Ile Ala Gly Gly Tyr Asn Trp Lys Leu Leu Glu Asn Ala 
                325                 330                 335     


Leu Glu Asp Phe Tyr Ser Lys Pro Tyr Leu Val Asn Gly Lys Leu Pro 
            340                 345                 350         


Val Lys Tyr Lys Thr Val Val Asn Lys Lys Met Asn Gln Leu Ala Tyr 
        355                 360                 365             


Ser Phe Thr Glu Leu Gln Glu Ala Leu Asp Ala Gly Asp Ser Gly Ser 
    370                 375                 380                 


Ser Ile Thr Asp Leu Phe Gly Lys Tyr Ala Glu Leu His Ala Ala Tyr 
385                 390                 395                 400 


Ala Ala Ala Asp Gly Asn Val Phe Tyr Lys Glu Tyr Asp Arg Lys Ser 
                405                 410                 415     


Ile Ala Ser Leu Lys Asn Tyr Leu Asp Ala Val Asn Ala Ile Ala Arg 
            420                 425                 430         


Phe Ile Lys Ile Phe Ala Ala Pro Glu Val Tyr Val Lys Asp Glu Gly 
        435                 440                 445             


Phe Tyr Gly Ile Val Asp Gly Ala Ala Asp Lys Leu Arg Asp Phe Asp 
    450                 455                 460                 


Leu Leu Tyr Asn Met Val Arg Asn Tyr Ile Thr Lys Lys Pro Tyr Lys 
465                 470                 475                 480 


Lys Ser Lys Val Ala Leu Thr Phe Asn Ser Ser Ser Phe Gly Arg Gly 
                485                 490                 495     


Trp Asp Glu Asn Lys Ile Tyr Asp Glu Leu Thr Thr Ile Phe Thr Tyr 
            500                 505                 510         


Asn Gly Lys Tyr Tyr Leu Gly Val Ile Asn Lys Asn Asp Lys Pro Asp 
        515                 520                 525             


Leu Ala Ala Ala Val Ser Lys Asp Glu Gly Gly Tyr Lys Arg Met Val 
    530                 535                 540                 


Tyr Lys Thr Phe Asp Ile Val Lys Gln Leu Pro Arg Leu Ser Phe Thr 
545                 550                 555                 560 


Lys Ala Val Lys Ala His Phe Ala Glu Ser Asp Glu Asp Phe Ile Phe 
                565                 570                 575     


Asp Gly Pro Lys Phe Ala Lys Pro Leu Arg Val Pro Lys Glu Ile Tyr 
            580                 585                 590         


Leu Gln Ser Phe Thr Asp Asn Gly Asp Lys Leu Ala Asp Ser Ala Lys 
        595                 600                 605             


Lys Tyr Thr Lys Ala Tyr Leu Asp Met Ser Gly Asp Tyr Lys Gly Tyr 
    610                 615                 620                 


Tyr Glu Ala Ile Ile Lys Arg Ile Asp Tyr Thr Lys Glu Phe Leu Ser 
625                 630                 635                 640 


Ala Tyr Lys Ser Thr Ser Ile Tyr Asp Leu Ala Phe Leu Lys Pro Ala 
                645                 650                 655     


Gly Lys Ala Ala Gly Ser Leu Cys Trp Thr Arg His Ile 
            660                 665                 


<210> 563
<211> 1193
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 563
Met Lys Thr Phe Glu Asn Phe Thr Asn Leu Tyr Ser Leu Pro Arg Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Leu Tyr Lys Thr Lys Glu Leu Ile Asp 
            20                  25                  30          


Ser Lys Gln Glu Leu Phe Pro Lys Asp Lys Arg Ile Asp Glu Ile Tyr 
        35                  40                  45              


Gln Asn Ile Ile Lys Pro Cys Leu Asn Glu Leu His Ser Asp Phe Ile 
    50                  55                  60                  


Glu Lys Ser Met Glu Asn Lys Asp Phe Gln Asn Ile Pro Asp Asn Ile 
65                  70                  75                  80  


Leu Lys Ile Tyr Ser Asn Glu Lys Asn Ile Asp Asp Phe Lys Asn Ile 
                85                  90                  95      


Glu Lys Asp Leu Ile Lys Gln Ile Asn Trp Phe Leu Lys Ser Asn Lys 
            100                 105                 110         


Thr Phe Phe Ala Glu Asn Tyr Ser Asp Leu Leu Gly Lys Asn Ser Ile 
        115                 120                 125             


Asp Ile Ile Ile Lys Val Phe Trp Glu Lys Ile Tyr Lys Lys Asp Asp 
    130                 135                 140                 


Ser Trp Lys Ile Phe Leu Tyr Asn Asp Leu Leu Trp Lys Ser Tyr Glu 
145                 150                 155                 160 


Glu Leu Ile Asn Ile Tyr Phe Lys Trp Phe Ser Thr Tyr Leu Ser Asn 
                165                 170                 175     


Phe Asn Lys Asn Arg Glu Asn Leu Tyr Asp Lys Lys Asn Glu Ala Lys 
            180                 185                 190         


Val Trp Ser Val Ser Gly Arg Thr Ile Trp Glu Asn Phe Pro Arg Phe 
        195                 200                 205             


Leu Gln Asn Cys Ile Asn Phe Arg Asp Lys Leu Glu Lys Leu Asn Leu 
    210                 215                 220                 


Ser Ile Glu Gln Lys Asp Ile Phe Ile Thr Asn Asn Phe Trp Lys Cys 
225                 230                 235                 240 


Ile Ser Gln Lys Gln Ile Asp Tyr Tyr Asn Lys Ile Ile Trp Gln Ile 
                245                 250                 255     


Asn Ser Lys Thr Asn Glu Phe Asn Gln Lys Asn Gly Leu Lys Trp Asn 
            260                 265                 270         


Lys Lys Leu Pro Lys Leu Leu Leu Leu His Lys Gln Ile Leu Trp Lys 
        275                 280                 285             


Ser Glu Asn Glu Asn Ile Leu Asn Phe Ile Asn Asn Ile Ile Gln Thr 
    290                 295                 300                 


Asp Phe Glu Leu Glu Gln Glu Ile Lys Ile Ile Asn Lys Asp Ile Phe 
305                 310                 315                 320 


Gln Arg Ile Asp Phe Ile Lys Lys Ser Ile Val Ser Asn Ile Glu Asp 
                325                 330                 335     


Phe Glu Leu Glu Lys Ile Phe Ile Lys Lys Asn Arg Leu Lys Asp Ile 
            340                 345                 350         


Ser Ser Leu Leu Met Asp Asn Tyr Ser Val Leu Glu Lys Leu Leu Pro 
        355                 360                 365             


Glu Phe Asn Glu Glu Trp Lys Ile Ile Lys Glu Asn Glu Leu Val Asn 
    370                 375                 380                 


Leu Ser Lys Ile Lys Lys Ser Phe Glu Asn Ile Asp Leu Lys Asp Leu 
385                 390                 395                 400 


Lys Asn Ile Phe Lys Lys Glu Tyr Phe Asp Glu Ser Lys Asp Trp Phe 
                405                 410                 415     


Lys Leu Phe Leu Asn Trp Ile Tyr Asn His Phe Ser Asp Leu Glu Asn 
            420                 425                 430         


Asn Ile Lys His Thr His Lys Leu Val Gln Asp Lys Leu Ile Ser Trp 
        435                 440                 445             


Asn Phe Ser Glu Asn Ile Gln Lys Ser Glu Lys Asn Ile Asn Leu Arg 
    450                 455                 460                 


Asp Glu Ile Phe Val Ser Ser Lys Trp Leu Leu Lys Ala Tyr Leu Asp 
465                 470                 475                 480 


Ser Ile Leu Ala Leu Asp Arg Phe Val His Met Phe Asp Tyr Trp Glu 
                485                 490                 495     


Gln Lys Asp Phe Asp Ser Asn Phe Tyr Asn Asn Ile Glu Glu Tyr Ser 
            500                 505                 510         


Ile Asn Phe Ser Pro Phe Lys Thr Tyr Asn Ala Val Arg Asn Tyr Leu 
        515                 520                 525             


Thr Lys Lys Asn Tyr Ser Thr Asp Lys Ile Lys Leu Asn Phe Asp Tyr 
    530                 535                 540                 


Pro Asp Phe Leu Gly Ser Asn Ser Leu Trp Lys Tyr Ala Phe Ile Tyr 
545                 550                 555                 560 


Lys Asp Ser Lys Trp Phe Tyr Tyr Leu Trp Val Leu Asp His Ser Asn 
                565                 570                 575     


Ser Gln Ser Lys Tyr Lys Pro Gln Ile Leu Lys Asn Asn Thr Glu Phe 
            580                 585                 590         


Tyr Gln Leu Glu Tyr Lys Gln Ile Lys Phe Asn Thr Leu Ala Trp Lys 
        595                 600                 605             


Trp Tyr Ile Arg Asp Phe Trp Val Lys Tyr Ser Glu Asp Glu Asn Cys 
    610                 615                 620                 


Ile Ile Asn Leu Lys Thr Leu Ile Lys Lys Gln Tyr Leu Glu Arg Tyr 
625                 630                 635                 640 


Pro Val Leu Lys Glu Ile Val Asp Phe Gln Thr Asp Asp Lys Lys Ile 
                645                 650                 655     


Phe Asp Ala Lys Val Lys Thr Ile Leu Glu Gln Ala Tyr Ser Ile Asn 
            660                 665                 670         


Phe Val Asn Ile Asp Lys Asn Tyr Ile Leu Glu Glu Asn Asn Asn Trp 
        675                 680                 685             


Asn Leu His Phe Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Asn Lys 
    690                 695                 700                 


Lys Ile Asn Ser Met Glu Asn Leu His Thr Met Tyr Phe Lys Ala Leu 
705                 710                 715                 720 


Phe Glu Lys Glu Asn Phe Asn Trp Trp Ala Cys Phe Lys Leu Asn Ser 
                725                 730                 735     


Gln Trp Ala Glu Ile Phe Phe Arg Glu Lys Ser Ile Asn Glu Lys Lys 
            740                 745                 750         


Val Lys Asp Leu Lys Thr Arg Asn Glu Asn Ala Ile Glu Lys Lys Arg 
        755                 760                 765             


Tyr Thr Glu Asn Lys Val Phe Leu His Leu Pro Ile Thr Leu Asn Phe 
    770                 775                 780                 


Ile Asn Lys Trp Tyr Ser Lys Tyr Ser Phe Trp Tyr Ile Asn Asp Ser 
785                 790                 795                 800 


Val Lys Lys Tyr Ile Lys Glu Asn Lys Ile Ser Ile Ile Trp Ile Asp 
                805                 810                 815     


Arg Trp Glu Lys Asn Leu Ile Tyr Phe Ser Met Ile Asn Glu Asn Leu 
            820                 825                 830         


Glu Ile Ile Glu Leu Lys Ser Leu Asn Ser Leu Ile Leu Lys Val Ser 
        835                 840                 845             


Asp Leu Glu Glu Lys Glu Val Asn Tyr Phe Glu Lys Leu Ser Lys Lys 
    850                 855                 860                 


Glu Trp Asn Arg Asn Lys Glu Arg Lys Asp Trp Asp Glu Ile Glu Thr 
865                 870                 875                 880 


Ile Lys Glu Leu Lys Glu Trp Tyr Ile Ser Gln Ile Val Asp Asn Leu 
                885                 890                 895     


Val Lys Leu Ile Val Lys His Asn Ala Ile Val Val Met Glu Asp Leu 
            900                 905                 910         


Asn Ser Gly Phe Lys Arg Trp Arg Gln Lys Ile Glu Lys Gln Ile Tyr 
        915                 920                 925             


Gln Lys Phe Glu Leu Ala Leu Ala Lys Lys Leu Asn Phe Thr Val Asp 
    930                 935                 940                 


Lys Asn Lys Lys His Asp Glu Leu Trp Trp Ile Tyr Lys Ala Tyr Gln 
945                 950                 955                 960 


Leu Thr Pro Gln Ile Glu Asn Phe Gln Asp Ile Tyr Ser Gln Thr Trp 
                965                 970                 975     


Ile Ile Phe Tyr Thr Gln Ala Ala Tyr Thr Ser Val Thr Cys Pro Asn 
            980                 985                 990         


Cys Ser Phe Arg Lys Asn Ile Tyr  Gln Lys Tyr Glu Asn  Glu Ser Lys 
        995                 1000                 1005             


Phe Lys  Glu Phe Phe Lys Lys  Tyr Ile Leu Glu Ile  Lys Phe Glu 
    1010                 1015                 1020             


Asp Asn  Cys Phe Ile Ile Lys  Tyr Lys Ile Asp Glu  Lys Ile Asp 
    1025                 1030                 1035             


Lys Lys  Lys Asn Lys Leu Lys  Lys Leu Glu Phe Gln  Val Asn Thr 
    1040                 1045                 1050             


Lys Asn  Gln Ile Arg Leu Lys  Phe Glu Lys Ser Leu  Lys Trp Lys 
    1055                 1060                 1065             


Trp Trp  Glu Thr Lys Glu Phe  Asn Ile Thr Glu Lys  Phe Lys Glu 
    1070                 1075                 1080             


Ile Phe  Glu Lys His Lys Leu  Asp Leu Trp Asn Leu  Lys Glu Glu 
    1085                 1090                 1095             


Leu Leu  Ala Trp Asn Trp Glu  Ile Gln Leu Tyr Lys  Asp Phe Met 
    1100                 1105                 1110             


Phe Tyr  Phe Asn Leu Leu Leu  Gln Leu Arg Asn Ser  Lys Glu Asn 
    1115                 1120                 1125             


Asp Asn  Trp Trp Tyr Ile Ser  Cys Pro Ser Cys Trp  Phe His Ser 
    1130                 1135                 1140             


Gly Asn  Trp Phe Gln Trp Phe  Ser Tyr Asn Trp Asp  Ala Asn Trp 
    1145                 1150                 1155             


Ala Tyr  Asn Ile Ala Arg Lys  Trp Arg Ile Ile Leu  Asp Lys Ile 
    1160                 1165                 1170             


Lys Lys  Asp Glu Lys Asn Leu  Trp Ile Thr Asn Val  Glu Trp Asp 
    1175                 1180                 1185             


Asn Tyr  Tyr Gln Lys 
    1190             


<210> 564
<211> 1583
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 564
Met Ser Phe Leu Val Pro His Leu Pro Thr Val Val Ser His Arg Leu 
1               5                   10                  15      


Gly Gly Tyr Ser Ser Ala Met Asp Gln Thr Pro Thr Arg Leu Thr Pro 
            20                  25                  30          


Ala Val Lys Asn Thr Ala Ala Ala Thr Pro Lys Pro Glu Val Pro Leu 
        35                  40                  45              


Thr Gln Arg Ala Tyr Thr Leu Arg Leu Arg Gly Ala Asn Asp Gly Asp 
    50                  55                  60                  


Gln Ser Trp Arg Glu Ala Val Trp Ala Thr His Glu Ala Val Asn Met 
65                  70                  75                  80  


Gly Ala Lys Val Phe Gly Asp Trp Leu Leu Thr Leu Arg Gly Gly Leu 
                85                  90                  95      


Asp Arg Glu Leu Ala Asp Ala Lys Val Lys Ala Gly Asn Asn Asn Pro 
            100                 105                 110         


Asp Arg Asn Pro Thr Pro Glu Glu Arg Arg Gly Arg Arg Val Leu Leu 
        115                 120                 125             


Ala Leu Ser Trp Leu Ser Val Glu Ser Ala Pro Lys Lys Gly Asp Ala 
    130                 135                 140                 


Tyr Glu Lys Phe Val Ile Ala Ser Gly Lys Lys Asp Ser Gln Ser Ile 
145                 150                 155                 160 


Arg Asp Glu Lys Val Val Arg Ala Leu Arg Glu Ile Leu Ala Lys Arg 
                165                 170                 175     


Gly Val Ala Asn Gln Asp Leu Glu Gly Trp Ile Val Asp Cys Glu Pro 
            180                 185                 190         


Ser Leu Ser Ala Ala Ile Arg Asp Asp Ala Val Trp Val Asn Arg Ser 
        195                 200                 205             


Ala Ala Phe Asp Ala Ala Gln Cys Arg Val Gly Thr Ser Leu Thr Arg 
    210                 215                 220                 


Glu Glu Ile Trp Asp Leu Leu Lys Pro Phe Phe Gly Ser Cys Glu Ser 
225                 230                 235                 240 


Tyr Leu Ala Ser Leu Thr Thr Asp Glu Asp Ser Asp Thr Glu Ala Ala 
                245                 250                 255     


Ala Thr Asp Asp Lys Ala Lys Asp Leu Val Gln Lys Ala Gly Gln Trp 
            260                 265                 270         


Leu Ser Ser Arg Phe Gly Thr Gly Lys Gly Ala Asp Phe Ala Ala Met 
        275                 280                 285             


Ser Lys Val Tyr Ser Glu Thr Ala Phe Trp Ala Gly Arg Ala Ser Pro 
    290                 295                 300                 


Phe Arg Ser Gly Ala Glu Ala Leu Arg Leu Ile Ala Glu Ser Leu Lys 
305                 310                 315                 320 


Ser Phe Cys Pro Lys Ser Phe Asp Ala Asp Gly Ile Leu Gly Leu Ile 
                325                 330                 335     


Ser Gly Pro Gly Tyr Lys Ser Ala Thr Arg Asn Ile Ile Lys Ala Trp 
            340                 345                 350         


Ser Lys Arg Ala Gly Pro Val Thr Ala Asp Asp Leu Ala Asn Leu Ser 
        355                 360                 365             


Ala Val Ala Ala Glu Asp Ala Asn Lys Cys Ser Ala Asn Thr Gly Ser 
    370                 375                 380                 


Lys Gly His Arg Pro Trp Ser Asp Ala Ile Leu Cys Glu Val Glu Asn 
385                 390                 395                 400 


Ala Cys Gly Phe Thr Tyr Leu Gln Pro Asp Gly Pro Ala Leu His Ser 
                405                 410                 415     


Glu Phe Ala Val Met Leu Asp His Ala Ala Arg Arg Val Ser Ile Gly 
            420                 425                 430         


His Ser Trp Ile Lys Arg Ala Glu Ala Glu Arg Asp Arg Phe Thr Lys 
        435                 440                 445             


Asp Ala Leu Arg Ile Lys Glu Val Pro Asp Pro Ile Arg Val Cys Leu 
    450                 455                 460                 


Asp Arg Phe Cys Ala Asp Arg Ala Gly Thr Ser Gly Ala Ile Asp Gly 
465                 470                 475                 480 


Tyr Arg Ile Arg Lys Arg Ala Val Ser Ala Trp Lys Glu Val Ile Thr 
                485                 490                 495     


Arg Trp Gly Gln Ala Ala Cys Lys Thr Ala Glu Asp Arg Val Ile Ala 
            500                 505                 510         


Val Arg Glu Thr Gln Ala Asp Pro Asp Ile Asp Lys Phe Gly Asp Ile 
        515                 520                 525             


Gln Leu Phe Glu Ala Leu Ala Val Asp Asp Ala Glu Cys Val Trp Arg 
    530                 535                 540                 


Val Asn Gly Glu Val Thr Pro Gln Pro Leu Ile Asp Tyr Ala Ala Ala 
545                 550                 555                 560 


Thr Asp Ala Glu Ala Lys Gln Lys Arg Phe Lys Val Pro Ala Tyr Arg 
                565                 570                 575     


His Pro Asp Pro Leu Ser His Pro Val Phe Cys Asp Phe Gly Asn Ser 
            580                 585                 590         


Arg Trp Lys Ile Arg Phe Ala Ala His Asp Ala Val Thr Lys Leu Ala 
        595                 600                 605             


Asn Ala Arg Thr Ser Leu Asp Arg Arg Glu Ala Asp Leu Ala Lys Ala 
    610                 615                 620                 


Lys Glu Arg Leu Asp Lys Ala Thr Ala Pro Glu Glu Gln Thr Glu Gly 
625                 630                 635                 640 


Lys Glu Ser Leu Glu Glu Ala Glu Arg His Leu Arg Asp Ala Arg Asp 
                645                 650                 655     


Arg Val Ala Trp Leu Ser Ser Met His Ala Phe Ser Met Arg Leu Trp 
            660                 665                 670         


Gly Ala Gly Arg Val Gly Asp Gly Gln Arg Leu Phe Trp Ser Cys Lys 
        675                 680                 685             


Arg Leu Thr Asp Asp Met Ala Leu Arg Gln Asn Ser Gly Gln Ala Pro 
    690                 695                 700                 


Thr Ile Ala Val Thr Arg Ala Asp Arg Leu Gly Arg Ala Ala Ala Gly 
705                 710                 715                 720 


Ala Asp Thr Ala Asp Ser Val Asp Ile Leu Gly Val Phe Thr Glu Glu 
                725                 730                 735     


His Trp Asn Gly Arg Leu Gln Ala Pro Arg Ala Gln Leu Asp Val Ile 
            740                 745                 750         


Ala Ala His Val Ala Lys Asn Gln Trp Asp Ala Lys Ala Lys Lys Met 
        755                 760                 765             


Arg Asp Arg Ile Arg Trp Leu Val Ser Phe Ser Ala Lys Leu Gln Pro 
    770                 775                 780                 


Val Gly Pro Trp Ile Glu Tyr Ser Ala Thr Phe Pro Glu Ala Ala Leu 
785                 790                 795                 800 


Ala Lys Pro Phe Val Ser Arg Lys Gly Glu Tyr Ala Val Arg His Val 
                805                 810                 815     


Ser Asn Asp Asp Arg Ala Gly Leu Gly Lys Leu Val Leu Ser Arg Leu 
            820                 825                 830         


Pro Gly Leu Arg Val Leu Ser Val Asp Leu Gly His Arg Tyr Ala Ala 
        835                 840                 845             


Ala Cys Ala Val Trp Glu Thr Val Ser Ile Ala Gln Thr Asn Ala Ala 
    850                 855                 860                 


Cys Asp Ala Ala Gly His Glu Leu Pro Thr Glu Ser Asp Leu Phe Leu 
865                 870                 875                 880 


Gln Leu Ser Thr Thr Asp Leu Thr Gly Lys Asn Arg Thr Thr Ile Tyr 
                885                 890                 895     


Arg Arg Ile Gly Ala Asp Met Ile Thr Asp Pro Lys Thr Gly Glu Lys 
            900                 905                 910         


Thr Pro His Pro Ala Pro Trp Ala Arg Leu Glu Arg Gln Phe Leu Val 
        915                 920                 925             


Lys Leu Pro Gly Glu Asp Ile Pro Ala Arg Lys Ala Ser Pro Ala Glu 
    930                 935                 940                 


Phe Asp Ala Ile Arg Arg Leu Glu Glu Ala Phe Gly Arg Thr Arg Thr 
945                 950                 955                 960 


Ala Asp Asp Pro Leu Leu Val Arg Val Asp Glu Leu Leu Ala Ala Thr 
                965                 970                 975     


Val Asp Ser Ala Arg Leu Ala Leu Arg Arg His Gly Asp Ala Ala Arg 
            980                 985                 990         


Ile Ala Tyr Ala Phe Lys Pro Ser  Ala Glu Lys Leu Thr  Pro Gly Gly 
        995                 1000                 1005             


Gly Arg  Glu Val Met Ser Pro  Glu Ala Arg Lys Ala  Met Ile Leu 
    1010                 1015                 1020             


Asp Ala  Leu Leu Leu Trp His  Gly Leu Trp His Gly  Asp Arg Trp 
    1025                 1030                 1035             


Ala Asp  Val Trp Ala Ser Gln  Gln Trp Asp Ala Tyr  Ile Lys Pro 
    1040                 1045                 1050             


Glu Leu  Gly Met Asp Leu Pro  Pro Trp Ser Glu Thr  Ser Gly Glu 
    1055                 1060                 1065             


Pro Arg  Cys Gln Tyr Arg Ser  Lys Val Glu Gly Leu  Leu Lys Arg 
    1070                 1075                 1080             


Val Ala  Glu Ser Leu Ala Ala  Arg Asp Gly Ala Gly  Leu His Leu 
    1085                 1090                 1095             


Leu Trp  Ala Glu Gln Trp Arg  Thr Arg Asn Ala Lys  Trp Leu Gly 
    1100                 1105                 1110             


Asn Thr  Gly His Leu Arg Thr  Leu Arg Ser Leu Leu  Leu Pro Arg 
    1115                 1120                 1125             


Gly Leu  Thr Thr Ser Thr Pro  Ala Ala Trp Asn Val  Gly Gly Leu 
    1130                 1135                 1140             


Ser Leu  Thr Arg Ile Ala Thr  Leu Lys Ser Leu Tyr  Gln Leu His 
    1145                 1150                 1155             


Lys Ala  Tyr His Met Arg Pro  Glu Pro Glu Asp Pro  Arg Lys Asn 
    1160                 1165                 1170             


Val Pro  Ala Lys Gly Glu Glu  Glu Leu Arg Asp Phe  Gly Arg Gly 
    1175                 1180                 1185             


Met Leu  Asp Val Met Glu Arg  Leu Arg Glu Gln Arg  Val Lys Gln 
    1190                 1195                 1200             


Leu Ala  Ser Arg Leu Ala Glu  Ala Ala Leu Gly Ile  Gly Arg Met 
    1205                 1210                 1215             


Lys Ala  Ser Glu Gly Lys Arg  Asp Arg Lys Arg Pro  Arg Ala Gln 
    1220                 1225                 1230             


Ile Asp  Gln Pro Cys His Ala  Val Val Ile Glu Asn  Leu Lys Asn 
    1235                 1240                 1245             


Tyr Arg  Pro Glu Glu Thr Arg  Thr Arg Arg Glu Asn  Arg Gln Leu 
    1250                 1255                 1260             


Met Ser  Trp Ser Ser Ser Lys  Val Lys Lys Tyr Leu  Ser Glu Ala 
    1265                 1270                 1275             


Cys Gln  Leu Asn Gly Leu His  Leu Arg Glu Val Gln  Ala Ser Tyr 
    1280                 1285                 1290             


Thr Ser  Arg Gln Asp Ser Arg  Thr Gly Ala Pro Gly  Ile Arg Cys 
    1295                 1300                 1305             


Ala Asp  Val Pro Val Gln Asp  Phe Phe Thr Lys Pro  Trp Trp Arg 
    1310                 1315                 1320             


Arg Gln  Val Ser Ile Ala Val  Gly Arg Val Asn Gln  Gly Arg Gly 
    1325                 1330                 1335             


Asp Ala  Arg Glu Arg Phe Leu  Ala Asp Leu Asp Ala  Lys Trp Ser 
    1340                 1345                 1350             


Ala Ala  Glu Lys Ser Glu Arg  Ile Thr Ala Pro Pro  Leu Arg Ile 
    1355                 1360                 1365             


Pro Val  Asn Gly Gly Glu Leu  Phe Val Ser Ala Asp  Leu His Ser 
    1370                 1375                 1380             


Pro Ala  Ala Leu Gly Leu Gln  Ala Asp Leu Asn Ala  Ala Ala Asn 
    1385                 1390                 1395             


Ile Gly  Leu Lys Ala Leu Leu  Asp Pro Asp Trp Pro  Gly Lys Trp 
    1400                 1405                 1410             


Trp Phe  Val Pro Ala Ser Leu  Asp Ala Asp Gly Trp  Arg Val Pro 
    1415                 1420                 1425             


Ala Ala  Lys Ser Cys Ala Gly  Ala Glu Trp Val Lys  Asn Trp Lys 
    1430                 1435                 1440             


Val Gly  Gln Leu Gly Asp Ser  Tyr Ala Pro Asn Gly  Lys Pro Leu 
    1445                 1450                 1455             


Gln Pro  Thr Asp Asp Glu Gly  Val Lys Lys Ala Glu  Asp Gly Val 
    1460                 1465                 1470             


Lys Leu  Ala Lys Ala Ser Leu  Asp Asp Ala Glu Gln  Ala Leu Lys 
    1475                 1480                 1485             


Ala Ala  Lys Lys Thr Lys Arg  Lys Ala Glu Ile Asp  Val Ala Ser 
    1490                 1495                 1500             


Ala Arg  Ala Gln Glu Ala Lys  Lys Asn Val Asp Asp  Met Lys Lys 
    1505                 1510                 1515             


Ala Leu  Val Ala Ala Lys Lys  Gly Ala Ser Ala Lys  Glu Ile Ile 
    1520                 1525                 1530             


Asn Leu  Trp Arg Asp Pro Val  Gly Val Asp Pro Ala  Asp Phe Ala 
    1535                 1540                 1545             


Ser Gly  Glu Pro Trp Arg Ala  Tyr Thr Val Tyr Lys  Gln Arg Val 
    1550                 1555                 1560             


Glu Tyr  His Val Ile Asn Asp  Val Leu Arg Gly Arg  Ala Gly Pro 
    1565                 1570                 1575             


Arg Ser  Asp Arg Pro 
    1580             


<210> 565
<211> 1254
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 565
Met Ser Ile Thr Arg Ser Ile Lys Val Lys Leu Ile Val Pro Arg Asp 
1               5                   10                  15      


Ala Ser Leu Glu Ala Arg Gln Leu Arg Glu Gly Leu Trp Ala Thr His 
            20                  25                  30          


Leu Phe Val Asn Asp Gly Cys His Tyr Tyr Glu Arg Leu Leu Leu Glu 
        35                  40                  45              


Phe Arg Gln Arg Asp Val Cys Val Gly Lys Asp Asp Ala Gly Lys Asp 
    50                  55                  60                  


Val Ile Val Pro Ala Ala Glu Trp Ala Asp Arg Leu Arg Ala Arg Leu 
65                  70                  75                  80  


Gly Arg Asn Gly Met Val Pro Ser His Ile Glu Ala Ala Leu Pro Ile 
                85                  90                  95      


Phe Arg Glu Leu Tyr Glu Asn Met Val Pro Ser Ala Leu Lys Ala Lys 
            100                 105                 110         


Ser Gly Thr Gly Gln Ala Gly Arg Ser Trp His Ser Lys Leu Val Ser 
        115                 120                 125             


Pro Thr Ser Arg Gly Gly Glu Ala Ser Ala Ala Arg Ile Asp Val Leu 
    130                 135                 140                 


Arg Pro Leu Leu Pro Val Ser Gly Asp Asp Pro Ala Phe Glu Pro Ala 
145                 150                 155                 160 


Ala Arg Ala Leu Ile Glu Glu Ala Gly Asp Glu Leu Leu Thr Ser Thr 
                165                 170                 175     


Gly Arg Cys Pro Ala Trp Val Thr Ala Tyr Arg Lys Gly Pro Glu Gly 
            180                 185                 190         


Ser Ala Trp Val Glu Lys Leu Arg Ile Gln Leu Arg Glu Ala Val Glu 
        195                 200                 205             


Ala Gly Asp Phe Asp Pro Pro Ser Asp Pro Gln Ile Leu Ala Ala Gly 
    210                 215                 220                 


Ala Val Pro Ala Ala Pro Pro Leu Gly Ala Gly Ile Asp Ala Leu Arg 
225                 230                 235                 240 


Pro Leu Leu Pro Leu Leu Gly Gly Asp Pro Ala Phe Glu Pro Ala Ala 
                245                 250                 255     


Arg Ala Leu Val Glu Asp Ile Gly Asp Glu Leu Phe Thr Ser Thr Gly 
            260                 265                 270         


Arg Pro Pro Thr Trp Val Thr Ala His Pro Thr Trp Val Arg Ala His 
        275                 280                 285             


Arg Lys Asp Ala Glu Cys Leu Glu Ala Ala Asp Asp Phe Lys Trp Val 
    290                 295                 300                 


Glu Arg Leu Arg Gln Arg Leu Arg Asp Asp Ala Lys Ala Gly Lys Phe 
305                 310                 315                 320 


Glu Gln Pro Leu His Glu Arg Leu Gly Ala Leu Gly Ala Leu Pro Val 
                325                 330                 335     


Ala Lys Pro Ile Gly Ala Gly Arg Val Val Ser Arg Ala Asp Leu Thr 
            340                 345                 350         


Val Phe Glu Arg Gly Ala Met Glu Leu Ala Ile Glu His Leu Ile Gly 
        355                 360                 365             


Trp Glu Ser Ala Gly His Arg Ala Arg Ala Gln Tyr Val Glu Arg Lys 
    370                 375                 380                 


Lys Arg His Asp Asp Leu Leu Gln Trp Ile Glu Ala Glu Ala Pro Asp 
385                 390                 395                 400 


Ala Leu Leu Ala Val Arg Ala Tyr Glu Ala Ala Arg Thr Ile His Leu 
                405                 410                 415     


Ala Thr Leu Gly Glu Leu Gly Ala Ala Pro Gln Tyr Thr Leu Arg Leu 
            420                 425                 430         


Arg Glu Ile Arg Pro Trp Arg Lys Leu Arg Glu Trp Leu Leu Gln Asn 
        435                 440                 445             


Pro Asp Ala Thr Ile Asp Glu Arg Arg Arg Arg Leu Ala Thr Met Gln 
    450                 455                 460                 


Thr Asn Asp Pro Arg Gly Tyr Gly Gly Glu Ala Leu Ala Trp Leu Ala 
465                 470                 475                 480 


Ala Pro Glu Arg Arg Ala Leu Val Glu His Pro Ala Gly Asp Val Val 
                485                 490                 495     


Thr Arg Ile Ala Val Leu Asn Ile Arg Lys Ser Ile Leu Asp Arg Ser 
            500                 505                 510         


Arg Leu Phe Pro Thr Cys Thr Leu Ala Asp Pro Val Glu His Pro Arg 
        515                 520                 525             


Phe Ala Lys Phe Gly Lys Pro Gly Asp Lys Asn Ser Ala Gly Tyr Ala 
    530                 535                 540                 


Leu Ala Val Asp Gly Val Arg Arg Glu Ala Ile Ile Lys Ile Leu Val 
545                 550                 555                 560 


Pro Arg Gln Asp Gly Leu Leu Val Pro Thr Asp Leu Arg Val Pro Phe 
                565                 570                 575     


Ala Pro Ser Gly Gln Met Arg Asp Leu Arg Ala Ser Gly Leu Asp Ile 
            580                 585                 590         


Ser Tyr Glu Arg Gln Asp Gly Arg Gly Arg Gln Ala Ala Lys Leu Gln 
        595                 600                 605             


Gly Gly Asn Leu Met Phe Asp Arg Thr His Phe Ala Arg Cys Gly Ala 
    610                 615                 620                 


Pro Gly Pro Glu Ala Leu Gly Ser Val Trp Ile Lys Val Ala Leu Asp 
625                 630                 635                 640 


Leu Ser Ser Pro Ala Ala Ser Leu Ala Met Lys Thr Ala Thr Pro Val 
                645                 650                 655     


Arg Thr Tyr Leu Ser Thr Ala Val Arg Gly Arg Pro Glu Ser Thr Lys 
            660                 665                 670         


Tyr Glu Lys Ala Ala Pro Pro Glu Gly Phe Arg Val Leu Ser Val His 
        675                 680                 685             


Met Gly Leu Arg Thr Ala Ala Thr Ala Ser Met Leu Arg Phe Gly Ala 
    690                 695                 700                 


Pro Glu Glu Gly Gly His Glu Val Pro Val Ser Gly Leu Ala Gly Glu 
705                 710                 715                 720 


Thr Leu Val Ala Phe His Glu Arg Thr Val Thr Met Lys Leu Pro Gly 
                725                 730                 735     


Glu Asp Pro Asp Thr Arg Thr Glu Ala Asn Arg Gly Val Ala Lys Arg 
            740                 745                 750         


Glu Leu Arg Gly Leu Gly Arg Gly Ile Gly Cys Leu Lys Ala Ile Arg 
        755                 760                 765             


Arg Ala Ser Ala Ser Ala Thr Pro Glu Asp Arg Ala Glu Ala Leu Val 
    770                 775                 780                 


Ile Ile Glu Thr His Val Gly Gln Gly Asp Arg His Gly Trp Ala Pro 
785                 790                 795                 800 


Ala Glu Ala Val Gly Arg Leu Asp Pro His Gly Asp Pro Asp Asp Trp 
                805                 810                 815     


Lys Thr Ala Cys Ala Ala Leu Tyr Ala Ala Val Glu Ala Asp Leu Gly 
            820                 825                 830         


Val Ala Ile Ser Ser Trp Arg Lys Ala Ala Arg Ala Gly Gly Ala Thr 
        835                 840                 845             


Gly Met Leu Gly Gly Lys Ser Leu Trp Ala Val Asp His Leu Glu Arg 
    850                 855                 860                 


Ser Phe Arg Phe Leu Arg Ser Trp Asp Leu Arg Ala Arg Pro His Asp 
865                 870                 875                 880 


Gly Asp Pro Arg Arg Pro Arg Pro Gly Tyr Ala Ser Lys Leu Leu His 
                885                 890                 895     


His Ile Asp Gly Val Lys Asp Asp Arg Val Lys Thr Thr Ala Asp Arg 
            900                 905                 910         


Ile Val Gln Ala Ala Cys Gly Arg Ala Trp Ile Gly Gly Pro Thr Val 
        915                 920                 925             


Lys Arg Gly Thr Gln Asp Val Arg Leu Pro Gly Arg Trp Glu Gln Arg 
    930                 935                 940                 


Gly Pro Arg Ala Asp Leu Ile Leu Leu Pro Asp Leu Thr His Phe Arg 
945                 950                 955                 960 


Phe Arg Ser Asp Arg Pro Arg Ala Glu Asn Ser Arg Leu Met Arg Trp 
                965                 970                 975     


Ala His Arg Gln Leu Ala Ile Tyr Val Arg Met Gln Ala Glu Val Glu 
            980                 985                 990         


Gly Ile Leu Val Ala Asp Thr Gly  Ala Ala Phe Thr Thr  Arg Phe Asp 
        995                 1000                 1005             


Ala Trp  Thr Gly Ala Pro Gly  Val Arg Cys Glu Pro  Val Thr Ala 
    1010                 1015                 1020             


Asp His  Leu Arg Gly Ile Ala  Lys Arg Glu Asp Tyr  Trp Leu Ala 
    1025                 1030                 1035             


Arg Leu  Leu Arg Glu Gly Ala  Leu Lys His Leu Arg  Ile Asp Pro 
    1040                 1045                 1050             


Ala Ser  Leu Arg Val Asp Asp  Leu Val Pro Met Asp  His Gly Lys 
    1055                 1060                 1065             


Ile Leu  Val Ala Leu Asp Gly  Val Asp Leu Pro Gly  Leu Arg Ile 
    1070                 1075                 1080             


Leu Asp  Thr Asp Val Asn Ala  Ser Gln Gly Leu Gly  Arg Arg Tyr 
    1085                 1090                 1095             


Ile Glu  Gly His Gly Leu Ala  Tyr Arg Leu Pro Gly  Ala Arg Val 
    1100                 1105                 1110             


Pro Arg  Gly Glu Gly Glu Arg  Glu Ala Ala Val Val  His Ile Lys 
    1115                 1120                 1125             


Gly Lys  Arg Leu Ala Ser Ala  Met Gly Gly Thr Val  Val Val Leu 
    1130                 1135                 1140             


Arg Ala  Ser Glu Gly Pro Gly  Asp Ile Thr Trp Thr  Ala Glu Val 
    1145                 1150                 1155             


Tyr Asp  Arg Pro Gln Gly Ala  Arg Lys Ala Leu Gly  Leu Ser Leu 
    1160                 1165                 1170             


Ala Ala  Phe Asn Ser Ile Ala  Thr Ala Ala Val Asp  Asp Glu Gly 
    1175                 1180                 1185             


Pro Ala  Pro Glu Asn Asp Asp  Glu Ala Leu Glu Glu  Glu Ala Glu 
    1190                 1195                 1200             


Glu Ala  Leu Gly Ile Ala Thr  Gly Glu Arg Ile Val  Phe Phe Arg 
    1205                 1210                 1215             


Asp Pro  Ser Gly Ala Val Ala  Gly Gly Gly Trp Leu  Glu Ala Ser 
    1220                 1225                 1230             


Ala Phe  Trp Gly Ile Ala Asn  Arg Met Val Thr Asp  Arg Leu Arg 
    1235                 1240                 1245             


Glu Leu  Gly Arg Leu Gly 
    1250                 


<210> 566
<211> 1468
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 566
Met Ala Thr Ala Val Asp Thr Ser Thr Thr Arg Ala Tyr Thr Leu Arg 
1               5                   10                  15      


Leu Ser Gly Gly Asn Asn Trp Arg Glu Leu Leu Trp Gln Thr His Val 
            20                  25                  30          


Ala Val Asn Arg Gly Ala Trp Val Trp Gly Asp Trp Leu Leu Thr Leu 
        35                  40                  45              


Arg Gly Gly Leu Pro Ala Ser Leu Ala Asp Gly Asp Ala Glu Arg Arg 
    50                  55                  60                  


Val Val Leu Ala Leu Ser Trp Leu Ser Val Glu Ser Pro Ala Ser Leu 
65                  70                  75                  80  


Ala Pro Gln Ala His Ile Val Ala Tyr Gly Ser Asp Ala Arg Asp Glu 
                85                  90                  95      


Arg Asn Arg Lys Val Thr Glu Arg Phe Arg Asp Ile Leu Arg Arg Met 
            100                 105                 110         


Gly Ile Lys Gln Gln Gln Glu Gln Glu Trp Leu Asp Ala Cys Leu Pro 
        115                 120                 125             


Ala Leu Met Ala Ser Ile Arg Glu Asp Ala Val Trp Val Asp Arg Ser 
    130                 135                 140                 


Ala Cys Phe Ala Glu Ala Gln Gln Cys Tyr Arg Gly Leu Ser Ser Glu 
145                 150                 155                 160 


Trp Ala Arg Lys Thr Leu Phe Asp Phe Leu Gly Gly Glu Asp Asp Tyr 
                165                 170                 175     


Phe Lys Pro Ser Ala Lys Glu Gly Ala Ser Ser Lys Ala Lys Asp Phe 
            180                 185                 190         


Val Gln Lys Ala Gly Arg Trp Leu Ser Arg His Trp Gly Ala Gly Lys 
        195                 200                 205             


Lys Ser Asp Pro Arg Asp Ile Ser Thr Arg Leu Gly Lys Leu Ala Gly 
    210                 215                 220                 


Val Asp Pro Lys Ala Ile Asp Gly His Thr Gly Arg Ala Ala Leu Glu 
225                 230                 235                 240 


Asp Leu Leu Arg Thr Leu Gly Ser Arg Pro Ala Gln Asn Ala Asp Ala 
                245                 250                 255     


Glu Lys Leu Tyr Arg Gln Leu Lys Arg Ala Val Gly Trp Lys Gly Arg 
            260                 265                 270         


Pro Ser Lys Gly Ala Val Ala Leu Lys Lys Ile Arg Asp Ala Glu Arg 
        275                 280                 285             


Val Pro Asn Asp Leu Trp Lys Glu Ile Ala Ser Thr Leu Arg Glu Glu 
    290                 295                 300                 


Ala Ala Val Gln Ser Ser Gln Thr Ser Asp His Ala Ala Val Pro Asp 
305                 310                 315                 320 


Trp Arg Ser His Trp Pro Ala Glu Ile Thr Gly Leu Pro Met Pro Tyr 
                325                 330                 335     


Arg Val Asp Arg Asp Tyr Ile Trp Glu His Gly Val Met Leu Asp His 
            340                 345                 350         


Ala Leu Arg Arg Val Ser Ser Ala His Thr Trp Ile Lys Arg Ala Glu 
        355                 360                 365             


Ala Glu Arg Arg Arg Phe Gln Gln Asp Ala Ala Lys Met Gly Ser Ile 
    370                 375                 380                 


Pro Glu Glu Ala Arg Asn Trp Leu Asp Ala Phe Arg Glu Arg Arg Ser 
385                 390                 395                 400 


Ser Ser Ser Gly Ala Thr Gly Asp Tyr Leu Ile Arg Glu Arg Ala Ile 
                405                 410                 415     


Asn Gly Trp Asp Lys Val Val Gln Ala Trp Glu Thr Leu Gly Pro Asn 
            420                 425                 430         


Ser Thr Arg Asp Gln Arg Ile Ala Ala Ala Arg Asp Val Gln Ala Asn 
        435                 440                 445             


Leu Asp Glu Asp Glu Lys Phe Gly Asp Ile Gln Leu Phe Ala Gly Phe 
    450                 455                 460                 


Gly Asp Glu His Val Asp Asp Pro Glu Arg Cys Leu Ala Asp Asp Arg 
465                 470                 475                 480 


Ala Thr Cys Val Trp Arg Asn Ser Ser Gly Arg Ala Asp Gly Arg Ile 
                485                 490                 495     


Leu Lys Asp Tyr Val Ala Ala Thr Val Ala Glu His Asn Gln Arg Arg 
            500                 505                 510         


Phe Lys Val Pro Ala Tyr Arg His Pro Asp Pro Leu Arg His Pro Val 
        515                 520                 525             


Phe Val Asp Tyr Gly Lys Ser Arg Trp Ser Ile Asn Tyr Ser Ala Leu 
    530                 535                 540                 


Thr Ala Ala Gln Gln Arg Arg Lys Thr Thr Gln Lys Leu Ala Gln Ala 
545                 550                 555                 560 


Lys Thr Asp Asn Thr Arg Ala Lys Leu Gln Gln Gln Leu Ala Ser Thr 
                565                 570                 575     


Ala Asp Leu Arg Ser Val Thr Leu Gly Val Trp Asp Gly Asn Arg Ile 
            580                 585                 590         


Val Lys Ile Ser Gln Arg Trp Arg Ser Lys Arg Phe Trp Arg Asp Leu 
        595                 600                 605             


Asp Leu Asp His Phe Gly Ser His Pro Ser Ala Ala Val Ser Arg Ala 
    610                 615                 620                 


Asp Arg Leu Gly Arg Val Ala Ala Arg Gln Asp Pro Gly Ala Ala Val 
625                 630                 635                 640 


Tyr Val Ala Lys Val Phe Glu Gln Gln Asp Trp Asn Gly Arg Leu Gln 
                645                 650                 655     


Val Pro Arg Arg Glu Leu Asn Arg Leu Ala Asp Val Val Tyr Gly Lys 
            660                 665                 670         


Gly Ala Asp Pro Asp Phe Gly Lys Leu Glu Arg Leu Asp Pro Arg Ala 
        675                 680                 685             


Arg Arg Leu Trp Glu Arg Leu Ser Trp Phe Leu Thr Thr Ser Ala Thr 
    690                 695                 700                 


Val Gln Pro Gln Gly Pro Trp Leu Asp Tyr Val Ala Ala Gly Leu Pro 
705                 710                 715                 720 


Ser Gly Ile Gln Tyr Thr Lys Ser Arg Ala Gly Tyr Tyr Leu Asn Tyr 
                725                 730                 735     


Asp Ala Asn His Gly Arg Lys Gly Arg Ala Arg Leu Cys Leu Ala Arg 
            740                 745                 750         


Leu Pro Gly Leu Arg Val Leu Ser Leu Asp Leu Gly His Arg Tyr Ala 
        755                 760                 765             


Ala Ala Cys Ala Val Trp Gln Thr Leu Thr Ile Glu Gln Met Thr Asn 
    770                 775                 780                 


Glu Cys Arg Gln Ala Ala His Pro Ala Pro Ser Asn Asp Asp Leu Phe 
785                 790                 795                 800 


Ile His Leu Arg His Pro Thr His Lys Pro Gln Lys Ser Gly Arg Lys 
                805                 810                 815     


Lys Gly Arg Pro Val Thr Lys Thr Thr Ile Tyr Arg Arg Ile Gly Pro 
            820                 825                 830         


Asp Lys Leu Pro Asp Gly Thr Asp His Pro Ala Pro Trp Ala Arg Leu 
        835                 840                 845             


Glu Arg Gln Phe Leu Ile Lys Leu Gln Gly Glu Asp Arg Pro Ala Arg 
    850                 855                 860                 


Tyr Ala Ser Gln Lys Glu Ile Asp Glu Val Asn Gln Phe Arg Asn Phe 
865                 870                 875                 880 


Val Gly Leu Glu Pro Ile Val Asp Arg Pro Arg Val Asp Asp Leu His 
                885                 890                 895     


Ser Asp Ala Val Arg Val Ala Arg Leu Gly Leu Arg Arg Leu Ala Asp 
            900                 905                 910         


Ala Ala Arg Ile Ala Phe Ala Met Thr Ala Ala Lys Lys Pro Ile Ser 
        915                 920                 925             


Gly Gly His Glu Val Glu Leu Thr Thr Ala Gln Arg Ile Glu Phe Leu 
    930                 935                 940                 


Gln Asp Ala Leu Leu Leu Trp Gln Ser Leu Ala Ala Ser Arg Arg Tyr 
945                 950                 955                 960 


Arg Asp Asp Trp Ala Glu Lys Leu Trp Gln Ser Trp Val Val Glu Lys 
                965                 970                 975     


Leu Gly Gly Pro Gln Pro Ala Glu Ile Ala Asp Asp Leu Pro Arg Ser 
            980                 985                 990         


Gln Arg Ala Ala Ser Leu Lys Thr  Ala Arg Gln Ser Leu  Arg Lys Val 
        995                 1000                 1005             


Ala Glu  Lys Leu Ser Asp Gly  Gln Ser Pro Ser Ala  Ala Glu Leu 
    1010                 1015                 1020             


His Arg  Leu Trp Ala Glu Arg  Trp Gln Gln Arg Gln  Thr Glu Trp 
    1025                 1030                 1035             


Arg Arg  His Leu Arg Trp Leu  Arg Arg Leu Ile Leu  Pro Arg Arg 
    1040                 1045                 1050             


Lys Asp  His Gln Gln Glu Asp  Arg Pro Leu Gln Arg  Val Gly Gly 
    1055                 1060                 1065             


Leu Ser  Val Lys Arg Ile Gln  Thr Ile Arg Gln Leu  Tyr Gln Val 
    1070                 1075                 1080             


Leu Lys  Ala Phe Arg Met Arg  Pro Glu Pro Ser Asp  Leu Arg Lys 
    1085                 1090                 1095             


Asn Ile  Pro Ala Pro Gly Asp  Arg Ser Leu Ala Ser  Phe Gly Arg 
    1100                 1105                 1110             


Arg Ile  Leu Asn His Leu Glu  Arg Leu Arg Glu Gln  Arg Ile Lys 
    1115                 1120                 1125             


Gln Leu  Ala Ser Arg Val Val  Glu Ala Ala Leu Gly  Ala Gly Arg 
    1130                 1135                 1140             


Ile Ser  Lys Pro Pro Gly Arg  Asp Arg Arg Arg Pro  Gln Gln Pro 
    1145                 1150                 1155             


Val Asp  Arg Pro Cys His Ala  Val Val Ile Glu Asn  Leu Gln His 
    1160                 1165                 1170             


Tyr Lys  Pro Glu Asp Ser Arg  Leu Arg Arg Glu Asn  Arg Gln Leu 
    1175                 1180                 1185             


Met Asp  Trp Gln Ala Arg Asn  Leu Arg Lys Tyr Ile  Val Glu Gly 
    1190                 1195                 1200             


Cys Glu  Leu His Gly Leu Leu  Phe Val Glu Val Ser  Pro Ala Tyr 
    1205                 1210                 1215             


Thr Ser  Arg Gln Asp Ser Arg  Thr Gly Ala Pro Gly  Leu Arg Cys 
    1220                 1225                 1230             


Glu Asp  Val Ser Arg Thr Ala  Leu Gln Glu Ala Ala  Arg Arg Met 
    1235                 1240                 1245             


His Ala  Ser His Ser Arg Pro  Ser Asn Ser Ser Pro  Gly Gly Ser 
    1250                 1255                 1260             


Gln Thr  Gln Phe Glu Arg Glu  Val Cys Arg Trp Ile  Asn Glu Phe 
    1265                 1270                 1275             


Lys Arg  Val Glu Gly Ser Ser  Ser Ser Leu Ser Ala  Arg Gln Ala 
    1280                 1285                 1290             


Val Leu  Lys Ala Phe Leu His  His Gln Ala Ser Ile  Pro Thr Ser 
    1295                 1300                 1305             


Leu Ser  Thr Ile Leu Leu Pro  Arg Arg Gly Gly Glu  Leu Phe Val 
    1310                 1315                 1320             


Ser Ala  Asp Pro Asp Ser Pro  Leu Ala Cys Gly Leu  Gln Ala Asp 
    1325                 1330                 1335             


Leu Asn  Ala Ala Ala Asn Ile  Gly Leu Lys Ala Leu  Thr Asp Pro 
    1340                 1345                 1350             


Asp Trp  Met Gly Ala Trp Trp  Phe Val Leu Val Asp  Arg Ala Ser 
    1355                 1360                 1365             


Gly Gln  Pro Val Glu Glu Gln  Val Gln Gly Cys Pro  Ile Trp Leu 
    1370                 1375                 1380             


Ser Cys  Gly Pro Leu Ser Asn  Ser Asn Pro Ala Thr  Ile Asp Pro 
    1385                 1390                 1395             


Ser Asp  Ser Pro Thr Ala Ala  Arg Arg Ser Asn Gly  Thr Gly Ala 
    1400                 1405                 1410             


Lys Gly  Arg Ala Arg Ala Asn  Glu Tyr Trp Trp Ser  Ser Leu Ser 
    1415                 1420                 1425             


Ala Thr  Thr Leu Pro Asp His  Lys Ala Trp Gln Pro  Thr Gln Asp 
    1430                 1435                 1440             


Tyr Trp  Arg Asp Ile Glu Gln  Arg Val Val Lys Arg  Leu Leu Arg 
    1445                 1450                 1455             


Leu Leu  Asp Gly Ser Glu Trp  Ser Glu Asp 
    1460                 1465             


<210> 567
<211> 669
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 567
Met Leu Asp Lys Phe Ala Ser Leu Tyr Pro Val Thr Lys Thr Leu Arg 
1               5                   10                  15      


Phe Arg Leu Leu Pro Gln Gly Arg Thr Glu Glu Asn Met Gln Val Ala 
            20                  25                  30          


Lys Val Leu Glu Asn Asp Leu Glu Arg Ser Glu Ala Ala Ala Val Val 
        35                  40                  45              


Lys Gly Leu Ile Lys Lys Tyr His Leu Gln Phe Ile Ser Asp Thr Leu 
    50                  55                  60                  


Ser Gly Ser Thr Leu Ser Trp Gln Ala Leu Thr Glu Thr Leu Asp Lys 
65                  70                  75                  80  


Phe Lys Ala Asp His Thr Ala Thr Ala Glu Leu Asp Ser Ala Leu Ala 
                85                  90                  95      


Ala Tyr Arg Cys Lys Leu Ala Glu Leu Phe Thr Lys Ser Pro Lys Tyr 
            100                 105                 110         


Lys Val Met Ala Thr Pro Val Ser Ile Ile Lys Glu Ile Leu Lys Thr 
        115                 120                 125             


Glu Thr Asp Pro Glu Asn Ile Ala Ala Leu Asn Lys Leu Asn Gly Tyr 
    130                 135                 140                 


Thr Tyr Ile Ile Phe Asp Tyr Val Ser Thr Arg Met Leu Thr Tyr Ser 
145                 150                 155                 160 


Ala Asp Ala Lys Ala Thr Ser Leu Ala Tyr Arg Leu Val Asp Glu Asn 
                165                 170                 175     


Tyr Leu Arg Phe Tyr Gln Asp Ile Ser Ala Ala Ala Glu Ile Ser Ala 
            180                 185                 190         


Val Leu Glu Glu Ala Gly Phe Asp Asn Ala Glu Val Glu Ala Phe Ile 
        195                 200                 205             


Arg Thr Asp Tyr Asn Thr Cys Leu Thr Ser Glu Gly Ile Ala Ser Phe 
    210                 215                 220                 


Asn Ala Ala Ala Gly Ser Ile Asn Gln Phe Val Asn Val Leu Leu Gln 
225                 230                 235                 240 


Gln Asn Pro Val Leu Gln Ser Glu Pro Ala Leu Arg Arg His Leu Gln 
                245                 250                 255     


Pro Leu Tyr Lys Met Leu Leu Asp Glu Ala Glu Ser Lys Ile Ile Lys 
            260                 265                 270         


Phe Glu Asp Tyr Gly Gln Leu Arg Asp Ala Val Glu Asn Phe Arg Arg 
        275                 280                 285             


Asn Phe Gln Asp Leu Pro Gln Ser Leu Ile Asp Ile Phe Ala Gly Arg 
    290                 295                 300                 


Tyr Asp Tyr Ser Lys Ile Tyr Val Gly Tyr Lys Tyr Leu Asn Glu Ala 
305                 310                 315                 320 


Ser Ser Gln Ile Ala Gly Gly Tyr Asn Trp Lys Leu Leu Glu Asn Ala 
                325                 330                 335     


Leu Glu Asp Phe Tyr Ser Lys Pro Tyr Leu Val Asn Gly Lys Leu Pro 
            340                 345                 350         


Val Lys Tyr Lys Thr Val Val Asn Lys Lys Met Asn Gln Leu Ala Tyr 
        355                 360                 365             


Ser Phe Thr Glu Leu Gln Glu Ala Leu Asp Ala Gly Asp Ser Gly Ser 
    370                 375                 380                 


Ser Ile Thr Asp Leu Phe Gly Lys Tyr Ala Glu Leu His Ala Ala Tyr 
385                 390                 395                 400 


Ala Ala Ala Asp Gly Asn Val Phe Tyr Lys Glu Tyr Asp Arg Lys Ser 
                405                 410                 415     


Ile Ala Ser Leu Lys Asn Tyr Leu Asp Ala Val Asn Ala Ile Ala Arg 
            420                 425                 430         


Phe Ile Lys Ile Phe Ala Ala Pro Glu Val Tyr Val Lys Asp Glu Gly 
        435                 440                 445             


Phe Tyr Gly Ile Val Asp Gly Ala Ala Asp Lys Leu Arg Asp Phe Asp 
    450                 455                 460                 


Leu Leu Tyr Asn Met Val Arg Asn Tyr Ile Thr Lys Lys Pro Tyr Lys 
465                 470                 475                 480 


Lys Ser Lys Val Ala Leu Thr Phe Asn Ser Ser Ser Phe Gly Arg Gly 
                485                 490                 495     


Trp Asp Glu Asn Lys Ile Tyr Asp Glu Leu Thr Thr Ile Phe Thr Tyr 
            500                 505                 510         


Asn Gly Lys Tyr Tyr Leu Gly Val Ile Asn Lys Asn Asp Lys Pro Asp 
        515                 520                 525             


Leu Ala Ala Ala Val Ser Lys Asp Glu Gly Gly Tyr Lys Arg Met Val 
    530                 535                 540                 


Tyr Lys Thr Phe Asp Ile Val Lys Gln Leu Pro Arg Leu Ser Phe Thr 
545                 550                 555                 560 


Lys Ala Val Lys Ala His Phe Ala Glu Ser Asp Glu Asp Phe Ile Phe 
                565                 570                 575     


Asp Gly Pro Lys Phe Ala Lys Pro Leu Arg Val Pro Lys Glu Ile Tyr 
            580                 585                 590         


Leu Gln Ser Phe Thr Asp Asn Gly Asp Lys Leu Ala Asp Ser Ala Lys 
        595                 600                 605             


Lys Tyr Thr Lys Ala Tyr Leu Asp Met Ser Gly Asp Tyr Lys Gly Tyr 
    610                 615                 620                 


Tyr Glu Ala Ile Ile Lys Arg Ile Asp Tyr Thr Lys Glu Phe Leu Ser 
625                 630                 635                 640 


Ala Tyr Lys Ser Thr Ser Ile Tyr Asp Leu Ala Phe Leu Lys Pro Ala 
                645                 650                 655     


Gly Lys Ala Ala Gly Ser Leu Cys Trp Thr Arg His Ile 
            660                 665                 


<210> 568
<211> 677
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"


<220>
<221> MOD_RES
<222> (19)..(339)
<223> Any amino acid

<400> 568
Met Cys Ile Arg Asp Arg Asp Leu Ala Val Ala Ala Leu Asn Arg Gly 
1               5                   10                  15      


Asp Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Gly Gln Leu Asn Ala Ile Arg Asn Phe Leu Ala Ser Asp 
            340                 345                 350         


Gly Tyr Gly Ala His Asp Leu Val Pro Val Asn Tyr Asn Gly Ser Asn 
        355                 360                 365             


Asp Arg Gly Ala Glu Val Gln Val Gly Asn Gln Lys Asn Trp Thr Val 
    370                 375                 380                 


Thr Ser Ser Ala Pro Val Val Val Gln Tyr Asn Asn Ala Asp Thr Thr 
385                 390                 395                 400 


Leu Thr Val Gln Gly His Thr Asp Arg Leu Ile Val Thr Gly Ser Gly 
                405                 410                 415     


Asn Asp Thr Ile Thr Leu Lys Asp Ser Gly Asp Asp Lys Val Leu Leu 
            420                 425                 430         


Gly Asp Gly Asn Asn Thr Val Val Ala Gly Ser Gly Ala Asp Thr Ile 
        435                 440                 445             


Val Gly Gly Ala Gly Asn Asp Val Leu Ile Gly Thr Asn Gly Gly Tyr 
    450                 455                 460                 


Gly Thr Glu Leu Leu Gly Gly Ala Gly Asn Asp Val Leu Arg Asn Ala 
465                 470                 475                 480 


Gly Ser His Gly Ile Tyr Met Asp Gly Gly Ala Gly Asn Asp Thr Phe 
                485                 490                 495     


Tyr Gly Gly Thr Gly Pro Asp Thr Met Glu Gly Gly Asp Gly Asn Asp 
            500                 505                 510         


Leu Met Tyr Ala Asn Gly Arg Gly Ser Ser Ile Asp Gly Gly Ala Gly 
        515                 520                 525             


Asn Asp Thr Ile Tyr Gly Gly Pro Gly Gly Asp Thr Leu Thr Gly Gly 
    530                 535                 540                 


Asp Gly Asn Asp Leu Leu Arg Ser Asp Ser Ala Phe Gly Thr Lys Gly 
545                 550                 555                 560 


Ser Gly Asn Leu Leu Val Gly Gly Ala Gly Asn Asp Thr Leu Trp Ala 
                565                 570                 575     


Gly Ala Gly Tyr Asp Thr Leu Lys Ala Gly Ser Gly Ser Asp Thr Leu 
            580                 585                 590         


Ile Ser Gly Thr Gly Ser Ser Gln Met Ile Gly Gly Ser Ser Gly Asn 
        595                 600                 605             


Thr Thr Phe Glu Val Ala Tyr His Thr Gly Asn Asp Thr Ile Thr Gly 
    610                 615                 620                 


Ser Gly Ser Gly Asn Thr Val Tyr Leu Asp Gly Arg Asp Phe Ser Asp 
625                 630                 635                 640 


Ala Thr Ile Ser Asn His Ser Gly Val Thr Thr Val Ser Phe Ser Asp 
                645                 650                 655     


Gly Gln Val Leu Lys Ile Ser Gly Val Gln Asp Ile Val Phe Ser Asp 
            660                 665                 670         


His Asp Tyr Lys Val 
        675         


<210> 569
<211> 1254
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 569
Met Ser Ile Thr Arg Ser Ile Lys Val Lys Leu Ile Val Pro Arg Asp 
1               5                   10                  15      


Ala Ser Leu Glu Ala Arg Gln Leu Arg Glu Gly Leu Trp Ala Thr His 
            20                  25                  30          


Leu Phe Val Asn Asp Gly Cys His Tyr Tyr Glu Arg Leu Leu Leu Glu 
        35                  40                  45              


Phe Arg Gln Arg Asp Val Cys Val Gly Lys Asp Asp Ala Gly Lys Asp 
    50                  55                  60                  


Val Ile Val Pro Ala Ala Glu Trp Ala Asp Arg Leu Arg Ala Arg Leu 
65                  70                  75                  80  


Gly Arg Asn Gly Met Val Pro Ser His Ile Glu Ala Ala Leu Pro Ile 
                85                  90                  95      


Phe Arg Glu Leu Tyr Glu Asn Met Val Pro Ser Ala Leu Lys Ala Lys 
            100                 105                 110         


Ser Gly Thr Gly Gln Ala Gly Arg Ser Trp His Ser Lys Leu Val Ser 
        115                 120                 125             


Pro Thr Ser Arg Gly Gly Glu Ala Ser Ala Ala Arg Ile Asp Val Leu 
    130                 135                 140                 


Arg Pro Leu Leu Pro Val Ser Gly Asp Asp Pro Ala Phe Glu Pro Ala 
145                 150                 155                 160 


Ala Arg Ala Leu Ile Glu Glu Ala Gly Asp Glu Leu Leu Thr Ser Thr 
                165                 170                 175     


Gly Arg Cys Pro Ala Trp Val Thr Ala Tyr Arg Lys Gly Pro Glu Gly 
            180                 185                 190         


Ser Ala Trp Val Glu Lys Leu Arg Ile Gln Leu Arg Glu Ala Val Glu 
        195                 200                 205             


Ala Gly Asp Phe Asp Pro Pro Ser Asp Pro Gln Ile Leu Ala Ala Gly 
    210                 215                 220                 


Ala Val Pro Ala Ala Pro Pro Leu Gly Ala Gly Ile Asp Ala Leu Arg 
225                 230                 235                 240 


Pro Leu Leu Pro Leu Leu Gly Gly Asp Pro Ala Phe Glu Pro Ala Ala 
                245                 250                 255     


Arg Ala Leu Val Glu Asp Ile Gly Asp Glu Leu Phe Thr Ser Thr Gly 
            260                 265                 270         


Arg Pro Pro Thr Trp Val Thr Ala His Pro Thr Trp Val Arg Ala His 
        275                 280                 285             


Arg Lys Asp Ala Glu Cys Leu Glu Ala Ala Asp Asp Phe Lys Trp Val 
    290                 295                 300                 


Glu Arg Leu Arg Gln Arg Leu Arg Asp Asp Ala Lys Ala Gly Lys Phe 
305                 310                 315                 320 


Glu Gln Pro Leu His Glu Arg Leu Gly Ala Leu Gly Ala Leu Pro Val 
                325                 330                 335     


Ala Lys Pro Ile Gly Ala Gly Arg Val Val Ser Arg Ala Asp Leu Thr 
            340                 345                 350         


Val Phe Glu Arg Gly Ala Met Glu Leu Ala Ile Glu His Leu Ile Gly 
        355                 360                 365             


Trp Glu Ser Ala Gly His Arg Ala Arg Ala Gln Tyr Val Glu Arg Lys 
    370                 375                 380                 


Lys Arg His Asp Asp Leu Leu Gln Trp Ile Glu Ala Glu Ala Pro Asp 
385                 390                 395                 400 


Ala Leu Leu Ala Val Arg Ala Tyr Glu Ala Ala Arg Thr Ile His Leu 
                405                 410                 415     


Ala Thr Leu Gly Glu Leu Gly Ala Ala Pro Gln Tyr Thr Leu Arg Leu 
            420                 425                 430         


Arg Glu Ile Arg Pro Trp Arg Lys Leu Arg Glu Trp Leu Leu Gln Asn 
        435                 440                 445             


Pro Asp Ala Thr Ile Asp Glu Arg Arg Arg Arg Leu Ala Thr Met Gln 
    450                 455                 460                 


Thr Asn Asp Pro Arg Gly Tyr Gly Gly Glu Ala Leu Ala Trp Leu Ala 
465                 470                 475                 480 


Ala Pro Glu Arg Arg Ala Leu Val Glu His Pro Ala Gly Asp Val Val 
                485                 490                 495     


Thr Arg Ile Ala Val Leu Asn Ile Arg Lys Ser Ile Leu Asp Arg Ser 
            500                 505                 510         


Arg Leu Phe Pro Thr Cys Thr Leu Ala Asp Pro Val Glu His Pro Arg 
        515                 520                 525             


Phe Ala Lys Phe Gly Lys Pro Gly Asp Lys Asn Ser Ala Gly Tyr Ala 
    530                 535                 540                 


Leu Ala Val Asp Gly Val Arg Arg Glu Ala Ile Ile Lys Ile Leu Val 
545                 550                 555                 560 


Pro Arg Gln Asp Gly Leu Leu Val Pro Thr Asp Leu Arg Val Pro Phe 
                565                 570                 575     


Ala Pro Ser Gly Gln Met Arg Asp Leu Arg Ala Ser Gly Leu Asp Ile 
            580                 585                 590         


Ser Tyr Glu Arg Gln Asp Gly Arg Gly Arg Gln Ala Ala Lys Leu Gln 
        595                 600                 605             


Gly Gly Asn Leu Met Phe Asp Arg Thr His Phe Ala Arg Cys Gly Ala 
    610                 615                 620                 


Pro Gly Pro Glu Ala Leu Gly Ser Val Trp Ile Lys Val Ala Leu Asp 
625                 630                 635                 640 


Leu Ser Ser Pro Ala Ala Ser Leu Ala Met Lys Thr Ala Thr Pro Val 
                645                 650                 655     


Arg Thr Tyr Leu Ser Thr Ala Val Arg Gly Arg Pro Glu Ser Thr Lys 
            660                 665                 670         


Tyr Glu Lys Ala Ala Pro Pro Glu Gly Phe Arg Val Leu Ser Val His 
        675                 680                 685             


Met Gly Leu Arg Thr Ala Ala Thr Ala Ser Met Leu Arg Phe Gly Ala 
    690                 695                 700                 


Pro Glu Glu Gly Gly His Glu Val Pro Val Ser Gly Leu Ala Gly Glu 
705                 710                 715                 720 


Thr Leu Val Ala Phe His Glu Arg Thr Val Thr Met Lys Leu Pro Gly 
                725                 730                 735     


Glu Asp Pro Asp Thr Arg Thr Glu Ala Asn Arg Gly Val Ala Lys Arg 
            740                 745                 750         


Glu Leu Arg Gly Leu Gly Arg Gly Ile Gly Cys Leu Lys Ala Ile Arg 
        755                 760                 765             


Arg Ala Ser Ala Ser Ala Thr Pro Glu Asp Arg Ala Glu Ala Leu Val 
    770                 775                 780                 


Ile Ile Glu Thr His Val Gly Gln Gly Asp Arg His Gly Trp Ala Pro 
785                 790                 795                 800 


Ala Glu Ala Val Gly Arg Leu Asp Pro His Gly Asp Pro Asp Asp Trp 
                805                 810                 815     


Lys Thr Ala Cys Ala Ala Leu Tyr Ala Ala Val Glu Ala Asp Leu Gly 
            820                 825                 830         


Val Ala Ile Ser Ser Trp Arg Lys Ala Ala Arg Ala Gly Gly Ala Thr 
        835                 840                 845             


Gly Met Leu Gly Gly Lys Ser Leu Trp Ala Val Asp His Leu Glu Arg 
    850                 855                 860                 


Ser Phe Arg Phe Leu Arg Ser Trp Asp Leu Arg Ala Arg Pro His Asp 
865                 870                 875                 880 


Gly Asp Pro Arg Arg Pro Arg Pro Gly Tyr Ala Ser Lys Leu Leu His 
                885                 890                 895     


His Ile Asp Gly Val Lys Asp Asp Arg Val Lys Thr Thr Ala Asp Arg 
            900                 905                 910         


Ile Val Gln Ala Ala Cys Gly Arg Ala Trp Ile Gly Gly Pro Thr Val 
        915                 920                 925             


Lys Arg Gly Thr Gln Asp Val Arg Leu Pro Gly Arg Trp Glu Gln Arg 
    930                 935                 940                 


Gly Pro Arg Ala Asp Leu Ile Leu Leu Pro Asp Leu Thr His Phe Arg 
945                 950                 955                 960 


Phe Arg Ser Asp Arg Pro Arg Ala Glu Asn Ser Arg Leu Met Arg Trp 
                965                 970                 975     


Ala His Arg Gln Leu Ala Ile Tyr Val Arg Met Gln Ala Glu Val Glu 
            980                 985                 990         


Gly Ile Leu Val Ala Asp Thr Gly  Ala Ala Phe Thr Thr  Arg Phe Asp 
        995                 1000                 1005             


Ala Trp  Thr Gly Ala Pro Gly  Val Arg Cys Glu Pro  Val Thr Ala 
    1010                 1015                 1020             


Asp His  Leu Arg Gly Ile Ala  Lys Arg Glu Asp Tyr  Trp Leu Ala 
    1025                 1030                 1035             


Arg Leu  Leu Arg Glu Gly Ala  Leu Lys His Leu Arg  Ile Asp Pro 
    1040                 1045                 1050             


Ala Ser  Leu Arg Val Asp Asp  Leu Val Pro Met Asp  His Gly Lys 
    1055                 1060                 1065             


Ile Leu  Val Ala Leu Asp Gly  Val Asp Leu Pro Gly  Leu Arg Ile 
    1070                 1075                 1080             


Leu Asp  Thr Asp Val Asn Ala  Ser Gln Gly Leu Gly  Arg Arg Tyr 
    1085                 1090                 1095             


Ile Glu  Gly His Gly Leu Ala  Tyr Arg Leu Pro Gly  Ala Arg Val 
    1100                 1105                 1110             


Pro Arg  Gly Glu Gly Glu Arg  Glu Ala Ala Val Val  His Ile Lys 
    1115                 1120                 1125             


Gly Lys  Arg Leu Ala Ser Ala  Met Gly Gly Thr Val  Val Val Leu 
    1130                 1135                 1140             


Arg Ala  Ser Glu Gly Pro Gly  Asp Ile Thr Trp Thr  Ala Glu Val 
    1145                 1150                 1155             


Tyr Asp  Arg Pro Gln Gly Ala  Arg Lys Ala Leu Gly  Leu Ser Leu 
    1160                 1165                 1170             


Ala Ala  Phe Asn Ser Ile Ala  Thr Ala Ala Val Asp  Asp Glu Gly 
    1175                 1180                 1185             


Pro Ala  Pro Glu Asn Asp Asp  Glu Ala Leu Glu Glu  Glu Ala Glu 
    1190                 1195                 1200             


Glu Ala  Leu Gly Ile Ala Thr  Gly Glu Arg Ile Val  Phe Phe Arg 
    1205                 1210                 1215             


Asp Pro  Ser Gly Ala Val Ala  Gly Gly Gly Trp Leu  Glu Ala Ser 
    1220                 1225                 1230             


Ala Phe  Trp Gly Ile Ala Asn  Arg Met Val Thr Asp  Arg Leu Arg 
    1235                 1240                 1245             


Glu Leu  Gly Arg Leu Gly 
    1250                 


<210> 570
<211> 767
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 570
Met Ala Gln Ala Ser Ser Thr Pro Ala Val Ser Pro Arg Pro Arg Pro 
1               5                   10                  15      


Arg Tyr Arg Glu Glu Arg Thr Leu Val Arg Lys Leu Leu Pro Arg Pro 
            20                  25                  30          


Gly Gln Ser Lys Gln Glu Phe Arg Glu Asn Val Lys Lys Leu Arg Lys 
        35                  40                  45              


Ala Phe Leu Gln Phe Asn Ala Asp Val Ser Gly Val Cys Gln Trp Ala 
    50                  55                  60                  


Ile Gln Phe Arg Pro Arg Tyr Gly Lys Pro Ala Glu Pro Thr Glu Thr 
65                  70                  75                  80  


Phe Trp Lys Phe Phe Leu Glu Pro Glu Thr Ser Leu Pro Pro Asn Asp 
                85                  90                  95      


Ser Arg Ser Pro Glu Phe Arg Arg Leu Gln Ala Phe Glu Ala Ala Ala 
            100                 105                 110         


Gly Ile Asn Gly Ala Ala Ala Leu Asp Asp Pro Ala Phe Thr Asn Glu 
        115                 120                 125             


Leu Arg Asp Ser Ile Leu Ala Val Ala Ser Arg Pro Lys Thr Lys Glu 
    130                 135                 140                 


Ala Gln Arg Leu Phe Ser Arg Leu Lys Asp Tyr Gln Pro Ala His Arg 
145                 150                 155                 160 


Met Ile Leu Ala Lys Val Ala Ala Glu Trp Ile Glu Ser Arg Tyr Arg 
                165                 170                 175     


Arg Ala His Gln Asn Trp Glu Arg Asn Tyr Glu Glu Trp Lys Lys Glu 
            180                 185                 190         


Lys Gln Glu Trp Glu Gln Asn His Pro Glu Leu Thr Pro Glu Ile Arg 
        195                 200                 205             


Glu Ala Phe Asn Gln Ile Phe Gln Gln Leu Glu Val Lys Glu Lys Arg 
    210                 215                 220                 


Val Arg Ile Cys Pro Ala Ala Arg Leu Leu Gln Asn Lys Asp Asn Cys 
225                 230                 235                 240 


Gln Tyr Ala Gly Lys Asn Lys His Ser Val Leu Cys Asn Gln Phe Asn 
                245                 250                 255     


Glu Phe Lys Lys Asn His Leu Gln Gly Lys Ala Ile Lys Phe Phe Tyr 
            260                 265                 270         


Lys Asp Ala Glu Lys Tyr Leu Arg Cys Gly Leu Gln Ser Leu Lys Pro 
        275                 280                 285             


Asn Val Gln Gly Pro Phe Arg Glu Asp Trp Asn Lys Tyr Leu Arg Tyr 
    290                 295                 300                 


Met Asn Leu Lys Glu Glu Thr Leu Arg Gly Lys Asn Gly Gly Arg Leu 
305                 310                 315                 320 


Pro His Cys Lys Asn Leu Gly Gln Glu Cys Glu Phe Asn Pro His Thr 
                325                 330                 335     


Ala Leu Cys Lys Gln Tyr Gln Gln Gln Leu Ser Ser Arg Pro Asp Leu 
            340                 345                 350         


Val Gln His Asp Glu Leu Tyr Arg Lys Trp Arg Arg Glu Tyr Trp Arg 
        355                 360                 365             


Glu Pro Arg Lys Pro Val Phe Arg Tyr Pro Ser Val Lys Arg His Ser 
    370                 375                 380                 


Ile Ala Lys Ile Phe Gly Glu Asn Tyr Phe Gln Ala Asp Phe Lys Asn 
385                 390                 395                 400 


Ser Val Val Gly Leu Arg Leu Asp Ser Met Pro Ala Gly Gln Tyr Leu 
                405                 410                 415     


Glu Phe Ala Phe Ala Pro Trp Pro Arg Asn Tyr Arg Pro Gln Pro Gly 
            420                 425                 430         


Glu Thr Glu Ile Ser Ser Val His Leu His Phe Val Gly Thr Arg Pro 
        435                 440                 445             


Arg Ile Gly Phe Arg Phe Arg Val Pro His Lys Arg Ser Arg Phe Asp 
    450                 455                 460                 


Cys Thr Gln Glu Glu Leu Asp Glu Leu Arg Ser Arg Thr Phe Pro Arg 
465                 470                 475                 480 


Lys Ala Gln Asp Gln Lys Phe Leu Glu Ala Ala Arg Lys Arg Leu Leu 
                485                 490                 495     


Glu Thr Phe Pro Gly Asn Ala Glu Gln Glu Leu Arg Leu Leu Ala Val 
            500                 505                 510         


Asp Leu Gly Thr Asp Ser Ala Arg Ala Ala Phe Phe Ile Gly Lys Thr 
        515                 520                 525             


Phe Gln Gln Ala Phe Pro Leu Lys Ile Val Lys Ile Glu Lys Leu Tyr 
    530                 535                 540                 


Glu Gln Trp Pro Asn Gln Lys Gln Ala Gly Asp Arg Arg Asp Ala Ser 
545                 550                 555                 560 


Ser Lys Gln Pro Arg Pro Gly Leu Ser Arg Asp His Val Gly Arg His 
                565                 570                 575     


Leu Gln Lys Met Arg Ala Gln Ala Ser Glu Ile Ala Gln Lys Arg Gln 
            580                 585                 590         


Glu Leu Thr Gly Thr Pro Ala Pro Glu Thr Thr Thr Asp Gln Ala Ala 
        595                 600                 605             


Lys Lys Ala Thr Leu Gln Pro Phe Asp Leu Arg Gly Leu Thr Val His 
    610                 615                 620                 


Thr Ala Arg Met Ile Arg Asp Trp Ala Arg Leu Asn Ala Arg Gln Ile 
625                 630                 635                 640 


Ile Gln Leu Ala Glu Glu Asn Gln Val Asp Leu Ile Val Leu Glu Ser 
                645                 650                 655     


Leu Arg Gly Phe Arg Pro Pro Gly Tyr Glu Asn Leu Asp Gln Glu Lys 
            660                 665                 670         


Lys Arg Arg Val Ala Phe Phe Ala His Gly Arg Ile Arg Arg Lys Val 
        675                 680                 685             


Thr Glu Lys Ala Val Glu Arg Gly Met Arg Val Val Thr Val Pro Tyr 
    690                 695                 700                 


Leu Ala Ser Ser Lys Val Cys Ala Glu Cys Arg Lys Lys Gln Lys Asp 
705                 710                 715                 720 


Asn Lys Gln Trp Glu Lys Asn Lys Lys Arg Gly Leu Phe Lys Cys Glu 
                725                 730                 735     


Gly Cys Gly Ser Gln Ala Gln Val Asp Glu Asn Ala Ala Arg Val Leu 
            740                 745                 750         


Gly Arg Val Phe Trp Gly Glu Ile Glu Leu Pro Thr Ala Ile Pro 
        755                 760                 765         


<210> 571
<211> 1210
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 571
Met Asn Ile Ile Met Glu Asn Phe Glu Lys Phe Val Asn Leu Tyr Glu 
1               5                   10                  15      


Leu Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Phe Ser Gln Thr Lys 
            20                  25                  30          


Val Glu Leu Glu Lys Asp Trp Ile Ile Glu Lys Asp Arg Glu Ile Glu 
        35                  40                  45              


Glu Lys Tyr His Ile Ile Lys Glu Lys Leu Asp Thr Leu His Ile Lys 
    50                  55                  60                  


Phe Val Trp Gln Ala Leu Glu Trp Val Asp Leu Ser Leu Leu Glu Glu 
65                  70                  75                  80  


Tyr Ala Glu Leu Tyr Phe Ala Cys Lys Lys Asp Thr Lys Asn Lys Lys 
                85                  90                  95      


Leu Lys Ser Lys Phe Glu Lys Leu Glu Lys Lys Ile Arg Gln Glu Ile 
            100                 105                 110         


Thr Ser Phe Phe Asp Ala Glu Trp Asn Lys Trp Lys Glu Lys Tyr Gly 
        115                 120                 125             


Phe Leu Lys Lys Trp Trp Thr Ser Phe Leu Thr Glu Lys Glu Ile Leu 
    130                 135                 140                 


Asp Val Leu Ile Asp Ile Phe Pro Glu Asn Lys Asp Asp Phe Glu Ile 
145                 150                 155                 160 


Phe Lys Trp Phe Phe Thr Tyr Phe Ser Asn Phe Asn Glu Ser Arg Lys 
                165                 170                 175     


Asn Phe Tyr Lys Asp Glu Trp Lys Ala Gly Gln Ile Ala Thr Arg Ala 
            180                 185                 190         


Ile Asp Glu Asn Leu Thr Thr Phe Leu Glu Asn Ile Ile Lys Tyr Lys 
        195                 200                 205             


Asn Phe Lys Lys Glu Asn Pro Asp Phe Phe Thr Glu Asn Glu Glu Lys 
    210                 215                 220                 


Val Phe Glu Leu Asp Phe Tyr Asn Phe Cys Leu Thr Gln Lys Trp Ile 
225                 230                 235                 240 


Asp Asn Tyr Asn Glu Ile Ile Trp Ala Lys Ser Leu Glu Glu Trp Lys 
                245                 250                 255     


Asn Thr Gln Gly Val Asn Gln Arg Ile Asn Leu Leu Lys Gln Lys Asn 
            260                 265                 270         


Glu Lys Ser Asn Lys Lys Asn Leu Ser Tyr Pro Lys Phe Asp Ile Leu 
        275                 280                 285             


Tyr Lys Gln Ile Leu Ser Glu Lys Ser Glu Asn Asp Phe Ile Pro Asn 
    290                 295                 300                 


Ile Glu Asn Thr Glu Glu Leu Phe Thr Val Ile Gln Lys Ser Ile Lys 
305                 310                 315                 320 


Glu Asn Asp Lys Lys Ile Thr Glu Ile Asp Lys Leu Phe Lys Lys Phe 
                325                 330                 335     


Phe Leu Glu Glu Asn Asn Ile Asp Ile Trp Lys Val Tyr Ile Ser Lys 
            340                 345                 350         


Gln Ala Val Asn Thr Ile Ser Ser Lys Tyr Phe Glu Asn Trp Ser Ser 
        355                 360                 365             


Leu Trp Trp Tyr Leu Trp Glu Asn Ser Lys Lys Lys Tyr Phe Ser Leu 
    370                 375                 380                 


Trp Glu Ile Lys Glu Ala Leu Glu Asp Ile Lys Glu Lys Asn Ile Phe 
385                 390                 395                 400 


Lys Gly Glu Tyr Tyr Asn Asn Lys Ile Ala Phe Glu Asn Lys Ser Asn 
                405                 410                 415     


Phe Glu Asn Phe Leu Ala Ile Phe Tyr Tyr Glu Phe Gln Thr Asn Leu 
            420                 425                 430         


Ser Leu Leu Asn Trp Asn Gln Asn Asn Leu Glu Ser Leu Gln Glu Lys 
        435                 440                 445             


Glu Phe Lys Lys Glu Glu Lys Gln Val Asp Ile Ile Lys Lys Tyr Phe 
    450                 455                 460                 


Asp Ser Val Met Asp Leu Tyr Ala Met Ser Lys Tyr Phe Phe Val Asp 
465                 470                 475                 480 


Leu Lys Gln Ala Lys Asn Phe Pro Lys Asp Ile Glu Phe Tyr Asn Asp 
                485                 490                 495     


Phe Asp Leu Tyr Phe Ser Asp Tyr Glu Pro Trp Lys Val Tyr Asn Leu 
            500                 505                 510         


Val Arg Asn Phe Leu Thr Lys Lys Glu Val Lys Thr Asp Lys Phe Lys 
        515                 520                 525             


Leu Asn Phe Ser Asn Ser Gln Phe Leu Thr Gly Trp Asp Lys Asp Lys 
    530                 535                 540                 


Glu Lys Glu Arg Phe Trp Val Ile Leu Arg Lys Asn Glu Lys Tyr Phe 
545                 550                 555                 560 


Leu Ala Ile Leu Lys Lys Asn Asn Asn Lys Ile Phe Glu Asn Tyr Arg 
                565                 570                 575     


Glu Asn Asn Pro Thr Asp Phe Tyr Glu Lys Met Glu Tyr Lys Gln Leu 
            580                 585                 590         


Asn Asn Val Tyr Arg Gln Ile Pro Arg Leu Gly Phe Pro Leu Gln Lys 
        595                 600                 605             


Lys Leu Asp Ser Leu Lys Trp Lys Glu Leu Glu Glu Tyr Leu Glu Lys 
    610                 615                 620                 


Tyr Lys Asn Asn Phe Trp Tyr Asn Lys Glu Ile Ala Phe Ile Lys Glu 
625                 630                 635                 640 


Glu Phe Asp Ile Phe Gln Lys Asn Lys Glu Lys Trp Glu Lys Phe Asp 
                645                 650                 655     


Arg Glu Lys Leu Lys Lys Leu Ile Asp Tyr Tyr Lys Lys Val Val Leu 
            660                 665                 670         


Glu Lys Tyr Ser Asp Leu Tyr Asp Leu Lys Lys Leu Glu Asn Thr Asp 
        675                 680                 685             


Tyr Asp Glu Leu Val Asn Phe Tyr Asp Asp Val Glu Lys Ser Met Tyr 
    690                 695                 700                 


Ser Leu His Phe Thr Lys Ile Glu Thr Glu Phe Leu Glu Asn Leu Glu 
705                 710                 715                 720 


Lys Asn Trp Glu Ile Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser 
                725                 730                 735     


Asp Tyr Lys Lys Glu Asn Thr Lys Glu Asn Ile His Thr Lys Tyr Phe 
            740                 745                 750         


Lys His Leu Phe Ser Glu Glu Asn Leu Glu Asn Leu Lys Ile Lys Leu 
        755                 760                 765             


Ser Gly Trp Ala Glu Ile Phe Phe Arg Asp Lys Thr His Asn Leu Lys 
    770                 775                 780                 


Gln Lys Leu Asp Lys Asn Trp Lys Lys Met Phe Tyr Trp Glu Asn Lys 
785                 790                 795                 800 


Asp Lys Lys Val Leu Glu His Arg Arg Tyr Ala Lys Asp Ser Tyr Gly 
                805                 810                 815     


Phe His Ile Ser Ile Thr Leu Trp Ala Asn Asn Trp Asp Met Tyr Lys 
            820                 825                 830         


Phe Asn Gln Phe Phe Asn Lys Asn Phe Thr Pro Lys His Ile Ile Gly 
        835                 840                 845             


Ile Asp Arg Trp Glu Lys His Leu Ala Tyr Tyr Ser Val Ile Asp Leu 
    850                 855                 860                 


Glu Gly Asn Leu Val Glu Thr Asp Thr Leu Asn Ile Val Asn Gly Ile 
865                 870                 875                 880 


Asn Tyr Leu Glu Lys Leu Glu Asn Ile Glu Lys Ser Arg Met Gln Glu 
                885                 890                 895     


Arg Lys Ser Trp Trp Glu Ile Glu Asn Ile Lys Asn Leu Lys Asp Gly 
            900                 905                 910         


Tyr Ile Ser Ala Val Val Ser Lys Leu Thr Glu Leu Ile Glu Lys Tyr 
        915                 920                 925             


Gln Ala Ile Ile Val Phe Glu Asp Leu Asn Leu Gly Phe Lys Arg Trp 
    930                 935                 940                 


Arg Glu Lys Ile Glu Arg Gln Val Tyr Gln Lys Leu Glu Leu Ala Leu 
945                 950                 955                 960 


Ala Lys Lys Leu Asn Tyr Leu Thr Phe Lys Asn Lys Lys Asp Cys Glu 
                965                 970                 975     


Ile Trp Gly Val Leu Asn Gly Ile Gln Leu Val Pro Arg Val Lys Asp 
            980                 985                 990         


Tyr Gln Asp Ile Ala Asn Tyr Lys  Gln Ser Gly Ile Ile  Phe Tyr Thr 
        995                 1000                 1005             


Asn Pro  Ala Tyr Thr Ser Thr  Thr Cys Pro Glu Cys  Gly Trp Arg 
    1010                 1015                 1020             


Lys Thr  Leu Lys Phe Pro Ser  Lys Ile Thr Lys Thr  Ser Ile Leu 
    1025                 1030                 1035             


Glu Phe  Phe Lys Glu Ile Gln  Met Ser Phe Tyr Trp  Glu Lys Phe 
    1040                 1045                 1050             


Ser Phe  Thr Tyr Glu Asn Ile  Leu Trp Lys Ser Glu  Thr Leu Phe 
    1055                 1060                 1065             


Ser Asn  Val Lys Arg Thr Gln  Trp Asn Asn Lys Ser  Arg Lys Ile 
    1070                 1075                 1080             


Glu His  Lys Glu Asn Ile Thr  Gln Glu Leu Lys Ser  Val Phe Glu 
    1085                 1090                 1095             


Lys Tyr  Asn Ile Asn Leu Trp  Glu Asn Ile Ser Glu  Lys Leu Gln 
    1100                 1105                 1110             


Gln Thr  Asp Met Leu Leu Glu  Asp Leu Lys Val Leu  Phe Tyr Asn 
    1115                 1120                 1125             


Phe Lys  Leu Ile Asn Asn Ile  Arg Asn Ser Asp Ser  Lys Leu Glu 
    1130                 1135                 1140             


Glu Asp  Ile Ile Ser Cys Pro  Cys Cys Leu Phe Asn  Ser Glu Asn 
    1145                 1150                 1155             


Trp Phe  Lys Gly Ala Tyr Phe  Asn Gly Asp Ala Asn  Gly Ala Tyr 
    1160                 1165                 1170             


Asn Thr  Ala Arg Lys Gly Ile  Ile Met Leu Glu Asn  Ile Lys Val 
    1175                 1180                 1185             


Asn Pro  Glu Arg Ser Asn Leu  Phe Val Arg Asn Glu  Glu Trp Asp 
    1190                 1195                 1200             


Glu Phe  Leu Arg Glu Glu Phe  
    1205                 1210 


<210> 572
<211> 1187
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 572
Met Ser Lys Leu Phe Glu Asn Met Thr Asn Leu Tyr Ser Leu Asn Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Asn Thr Arg Glu Leu Ile 
            20                  25                  30          


Glu Ser Lys Asp Phe Phe Lys Asn Asp Glu Glu Lys Ala Glu Asn Tyr 
        35                  40                  45              


Gln Phe Met Lys Glu Lys Met Asp Lys Ile His Arg Asn Tyr Ile Gln 
    50                  55                  60                  


Lys Ser Leu Glu Thr Ile Lys Met Leu Pro Ile Leu Asp Gln Thr Glu 
65                  70                  75                  80  


Gln Lys Arg Leu Lys Lys Glu Asp Ile Lys Asn Glu Leu Lys Ser Leu 
                85                  90                  95      


Arg Ser Phe Ile Ser Ala Ala Phe Val Ser Val Lys Asp Leu Leu Ser 
            100                 105                 110         


Asn Lys Ile Ile Glu Trp Leu Ile Ser Glu Ala Ser Ile Glu Glu Lys 
        115                 120                 125             


Glu Lys Ile Lys Lys Phe Asp Lys Phe Phe Gly Tyr Phe Lys Thr Tyr 
    130                 135                 140                 


Val Gln Asn Arg Gly Asn Leu Tyr Lys Ala Glu Asp Lys Ala Gly Gln 
145                 150                 155                 160 


Ile Ala Phe Arg Leu Ile Asp Glu Asn Leu Pro Arg Phe Phe Lys Ala 
                165                 170                 175     


Lys Gln Ile Ile Glu Glu Ile Ile Lys Lys Thr Pro Asp Phe Val Val 
            180                 185                 190         


Lys Glu Arg Asn Glu Lys Gln Glu Glu Thr Glu Lys Lys Ile Thr Glu 
        195                 200                 205             


Tyr Leu Ser Ile Phe Tyr Leu Asn Ser Tyr Cys His Tyr Leu Ser Gln 
    210                 215                 220                 


Ser Gly Ile Asp Leu Phe Asn Glu Ile Val Gly His Ile Asn Leu Ser 
225                 230                 235                 240 


Ile Asn Leu Tyr Lys Gln Lys Thr Gly Val Lys Phe Ser Leu Ile Pro 
                245                 250                 255     


Leu Leu Tyr Lys Leu Pro Leu Ala Pro Arg Lys Gln Ile Ser Arg Leu 
            260                 265                 270         


Pro Lys Gln Ile Glu Asn Pro Glu Glu Leu Glu Leu Ile Val Lys Ser 
        275                 280                 285             


Val Leu Asp Arg Ile Asp Gln Lys Ile Asn Pro Phe Ile Asn Asn Ile 
    290                 295                 300                 


Leu Gln Thr Val Leu Glu Glu Asn Ser Val Tyr Asp Leu Asn Trp Ile 
305                 310                 315                 320 


Tyr Ile Ser Ile Lys Thr Thr Glu Gln Trp Trp Ser Ile Gly Leu Ser 
                325                 330                 335     


Gly Arg Asn Ser Leu Arg Glu Leu Gly Tyr Asn Gln Ser Lys Asn Trp 
            340                 345                 350         


Glu Glu Pro Val Leu Lys Ala Glu Lys Asn Lys Phe Pro Phe Ile Ser 
        355                 360                 365             


Leu Gly Glu Ile Lys Ser Phe Leu Asp Ala Lys Gln Leu Ala Trp Asp 
    370                 375                 380                 


Asp Ile Lys Ser Val Phe Trp Glu Gly Lys Ser Gln Ser Leu Met Asn 
385                 390                 395                 400 


Trp Ser Trp Ser Asn Ile Phe Phe His Leu Ile Gly Lys Glu Ile Ser 
                405                 410                 415     


Ser Leu Ile Glu Lys Tyr Leu His Ser Arg Lys Asn Tyr Gln Ile Ser 
            420                 425                 430         


Gln Ser Lys Glu Asn Gln Lys His Val Leu Asp Asn Ser Leu Ser Leu 
        435                 440                 445             


Trp Arg Leu Leu Gly Trp Phe Val Leu Met His Lys Lys Thr His Leu 
    450                 455                 460                 


Thr Pro Glu Ile Lys Glu Ser Phe Phe Tyr Asp Trp Glu Asn Gly Leu 
465                 470                 475                 480 


Asp Ala Ile Val Phe Asp Glu Asn Ser Asp Pro Ile His Thr Ile Tyr 
                485                 490                 495     


Asp Lys Val Arg Asn Cys Leu Thr Lys Lys Pro Tyr Ser Asn Lys Asp 
            500                 505                 510         


Lys Ile Lys Val Asn Phe Asp Cys Pro Tyr Leu Leu Trp Gly Trp Asp 
        515                 520                 525             


Gln Asn Tyr Asp Ala Phe Gly Trp Leu Ile Phe His Asp Trp Lys Lys 
    530                 535                 540                 


Tyr Phe Leu Trp Leu Ile Lys Gly Ser Trp Leu Asn Met Glu Glu Lys 
545                 550                 555                 560 


Asn Lys Leu Tyr Glu Trp Ile Asn Pro Met Asn Ser Ile Thr Lys Ile 
                565                 570                 575     


Ile Tyr Asp Tyr Gln Lys Pro Asp Phe Lys Asn Val Pro Arg Leu Phe 
            580                 585                 590         


Ile Arg Ser Lys Trp Asp Thr Phe Ala Pro Met Val Arg Glu Tyr Trp 
        595                 600                 605             


Leu Pro Val Asn Asp Ile Leu Tyr Leu Tyr Asp Asn Glu Leu Tyr Lys 
    610                 615                 620                 


Pro Asp Lys Lys Asn Pro Trp Lys His Lys Ser Tyr Leu Arg Arg Leu 
625                 630                 635                 640 


Ile Asp Tyr Phe Lys Leu Trp Leu Ser Lys His Lys Ser Phe Lys His 
                645                 650                 655     


Tyr Ile Phe Lys Arg Lys Glu Ser Asp Gln Tyr Glu Asn Leu Ala Glu 
            660                 665                 670         


Phe Tyr Ser Asp Val Glu Phe Ser Cys Tyr Ala Ile Lys Lys Glu Lys 
        675                 680                 685             


Val Asn Phe Asp Gln Val Lys Ala Leu Cys Glu Ser Glu Arg Leu Tyr 
    690                 695                 700                 


Leu Phe Glu Ile Tyr Asn Lys Asp Tyr Asn Gln Phe Ser Lys Trp Lys 
705                 710                 715                 720 


Asn Lys Asn Leu His Thr Gln Tyr Phe Glu Ala Leu Phe Glu Glu Arg 
                725                 730                 735     


Asp Asn Asn Leu Phe Met Leu Ser Gly Gly Trp Ser Ile Phe Trp Arg 
            740                 745                 750         


Glu Ser Asn Trp Lys Ile Val Glu Lys Ile Arg Ser Tyr Ser Pro Lys 
        755                 760                 765             


Tyr Asn Ile Glu Ile Ile Asp Lys Arg Arg Tyr Thr Lys Asn Lys Leu 
    770                 775                 780                 


Met Ile His Ile Pro Ile Val Leu Asn Phe Cys Arg Asn Gln Glu Trp 
785                 790                 795                 800 


Arg Val Asn Asp Met Ile Lys Ser Leu Ile Gln Ser Gln Ser Asn Asn 
                805                 810                 815     


Phe Thr Ile Leu Gly Ile Asp Arg Trp Glu Lys His Leu Leu Tyr Tyr 
            820                 825                 830         


Ser Leu Ile Arg Gln Asp Trp Thr Ile Ile Lys Thr Gly Ser Arg Asn 
        835                 840                 845             


Thr Ile Thr Asn Lys Ile Lys Ile Val Asp Tyr His Lys Lys Leu Asp 
    850                 855                 860                 


Asp Arg Glu Lys Lys Arg Asp Glu Ala Gln Ala Asn Trp Glu Gln Gln 
865                 870                 875                 880 


Glu Gln Ile Lys Asp Leu Lys Lys Trp Tyr Ile Ser Gln Val Ile Asn 
                885                 890                 895     


Glu Ile Ser Lys Met Ile Ile Glu His Asn Ala Ile Ile Val Leu Glu 
            900                 905                 910         


Asp Leu Asn Gly Trp Phe Lys Arg Trp Arg Gln Lys Val Glu Lys Ser 
        915                 920                 925             


Ile Tyr Gln Gln Phe Glu Leu Ala Leu Ala Lys Lys Leu Asn His Leu 
    930                 935                 940                 


Val Phe Lys Asn Arg Trp Asp Thr Glu Ser Trp Gly Thr Met Lys Ala 
945                 950                 955                 960 


Tyr Gln Leu Thr Pro Leu Val Ala Gln Phe Gln Asp Leu Ser Phe Gln 
                965                 970                 975     


Thr Trp Val Val Phe Tyr Thr Pro Ala Trp Tyr Thr Ser Thr Thr Cys 
            980                 985                 990         


Pro Cys Cys Gly Trp Arg Lys Asn  Ile Tyr Phe Lys Tyr  Glu Asn Glu 
        995                 1000                 1005             


Lys Gln  Ala Lys Ile Glu Leu  Glu Lys Leu Asn Ile  Val Arg Glu 
    1010                 1015                 1020             


Asn Asn  Tyr Phe Ser Ile Thr  Tyr Thr Ala Glu Trp  Trp Asn Lys 
    1025                 1030                 1035             


Lys Trp  Lys Ile Thr Trp Ser  Val Leu Asn Lys Thr  Asp Arg Ile 
    1040                 1045                 1050             


Leu Thr  Thr Lys Trp Gln Thr  Arg Leu Gln Tyr Asp  Arg Ala Ser 
    1055                 1060                 1065             


Lys Asn  Thr Lys Glu Tyr Asp  Ile Thr Thr Asp Phe  Asn Ser Val 
    1070                 1075                 1080             


Phe Thr  Ala Lys Phe Leu Asp  Tyr Lys Ile Arg Leu  Glu Asn Ala 
    1085                 1090                 1095             


Gly Ser  Lys Gln Cys Arg Asn  Leu Ile Asn Ser Ile  Asn Leu Leu 
    1100                 1105                 1110             


Leu Lys  Ile Arg Asn Ala Lys  Ser Gly Thr Asp Ile  Asp Thr Ile 
    1115                 1120                 1125             


Gln Cys  Pro Ala Cys Glu Phe  His Ser Gln Trp Trp  Phe Gln Trp 
    1130                 1135                 1140             


Asn Glu  Phe Asn Trp Asp Ala  Asn Trp Ala Tyr Asn  Ile Ala Arg 
    1145                 1150                 1155             


Lys Gly  Lys Val Ile Ile Asp  Lys Ile Val Lys Gly  Glu Lys Asn 
    1160                 1165                 1170             


Thr Thr  Val Ser Gln Ile Glu  Phe Asp Asn Glu Ile  Gln Lys 
    1175                 1180                 1185         


<210> 573
<211> 938
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 573
Pro Ala Tyr Arg His Pro Asp Pro Leu Leu His Pro Val Phe Cys Asp 
1               5                   10                  15      


Phe Gly Cys Ser Arg Trp Gln Ile Cys Phe Asp Val Arg Lys Asn Val 
            20                  25                  30          


Arg Thr Thr Ser Pro Arg Arg Leu Cys Leu Thr Leu Phe Thr Gly Ser 
        35                  40                  45              


Gly Met Glu Leu Val Pro Phe Ser Trp Gln Ser Lys Arg Leu Ala Arg 
    50                  55                  60                  


Asp Leu Ala Leu Glu Gln Arg His Arg Asn Pro Glu Ala Ser Glu Val 
65                  70                  75                  80  


Thr Arg Ala Asp Arg Leu Gly Arg Ala Ala Ala Gly Val Ser Ala Gly 
                85                  90                  95      


Gly Ala Val Ser Ile Lys Asn Ile Phe Asn Glu Glu Asn Trp Asn Gly 
            100                 105                 110         


Arg Leu Gln Ala Pro Arg Ser Gln Leu Ala Ala Ile Ala Ala Arg Val 
        115                 120                 125             


Asp Lys His Gly Trp Asp Ala Lys Ala Leu Arg Met Leu Asp Arg Leu 
    130                 135                 140                 


Arg Trp Leu Ile Thr Phe Ser Pro Arg Leu Glu Pro Thr Gly Pro Trp 
145                 150                 155                 160 


Ile Glu Tyr Ala Leu Arg Ile Pro Asp Asp Ala Ala Ala Lys Pro Phe 
                165                 170                 175     


Leu Ser Arg Lys Asn Gly Phe Ala Val Leu His Arg Ser Asn Asp Asp 
            180                 185                 190         


Arg Lys Gly Leu Ala Lys Leu Ile Leu Ser Arg Leu Pro Gly Leu Arg 
        195                 200                 205             


Val Leu Ser Val Asp Leu Gly His Arg Tyr Ala Ala Ala Cys Ala Val 
    210                 215                 220                 


Trp Glu Thr Leu Ser Ala Asp Gln Val Arg Glu Ala Cys Gln Ala Ala 
225                 230                 235                 240 


Gly His Asp Gly Pro Thr Glu Cys Asp Leu Tyr Leu His Leu Lys Lys 
                245                 250                 255     


Asp Gly Arg Thr Val Ile Tyr Arg Arg Ile Gly Ala Asp Thr Leu Ser 
            260                 265                 270         


Asp Gly Thr Pro His Pro Ala Pro Trp Ala Arg Leu Asp Arg Gln Phe 
        275                 280                 285             


Leu Ile Lys Leu Gln Gly Glu Glu His Lys Ala Arg Glu Ala Ser Asn 
    290                 295                 300                 


Ala Glu Ile Trp Ala Val His Gln Met Glu Ala Ala Leu Gly Arg Ser 
305                 310                 315                 320 


Val Pro Leu Ile Asp Arg Leu Val Ala Ser Gly Trp Gly Gln Arg Thr 
                325                 330                 335     


Glu Gly Gln Arg Ala Arg Leu Glu Ala Leu Lys Gln Leu Gly Trp Arg 
            340                 345                 350         


Pro Val Ala Glu Lys Leu Asp Ser Asp Asp Glu Pro Gly Val Met Glu 
        355                 360                 365             


Glu Ser Pro Ala Ile Lys Pro Ser Leu Ser Ile Asp Glu Leu Met Ser 
    370                 375                 380                 


Ser Ala Val Arg Thr Met Arg Leu Ala Leu Lys Arg His Gly Asp Arg 
385                 390                 395                 400 


Ala Arg Ile Ala His Tyr Leu Ile Thr Asp Glu Lys Thr Lys Pro Gly 
                405                 410                 415     


Asn Val Lys Glu Gln Leu Asp Glu Asn Gly Arg Ile Glu Leu Leu Gln 
            420                 425                 430         


Asp Ala Leu Val Leu Trp His Asp Leu Phe Ser Ser Lys Gly Trp Gln 
        435                 440                 445             


Asp Asn Lys Ala Lys Glu Leu Trp Tyr Val His Ile Ala Thr Leu Pro 
    450                 455                 460                 


Glu Tyr Lys Ala Phe Gln Ser Ser Gly Glu Gly His Ala Gly Pro Glu 
465                 470                 475                 480 


Arg Arg Gly Lys Pro Glu Glu Asp Arg Glu Lys Leu Gly Val Val Ala 
                485                 490                 495     


Gln Ala Leu Ala Pro Asn Val Thr Leu Arg Glu Ala Leu His Asn Ala 
            500                 505                 510         


Trp Lys Lys Arg Trp Glu Glu Asp Asp Ala Arg Trp Lys Ala Leu Leu 
        515                 520                 525             


Arg Trp Cys Lys Asp Trp Ile Leu Pro Arg Gly Glu Ala Ala Asn Ser 
    530                 535                 540                 


Pro Ala Ile Arg Lys Val Gly Gly Leu Ser Leu Ile Arg Leu Ala Thr 
545                 550                 555                 560 


Leu Thr Glu Phe Arg Arg Lys Val Gln Val Gly Phe Phe Ala Arg Leu 
                565                 570                 575     


Arg Pro Asp Gly Lys Lys Ala Glu Thr Gly Glu Lys Phe Gly Arg Lys 
            580                 585                 590         


Thr Leu Asp Ala Leu Glu Glu Leu Arg Glu Gln Arg Val Lys Gln Leu 
        595                 600                 605             


Ala Ser Arg Ile Ala Glu Ala Ala Leu Gly Ile Gly Lys Glu His Val 
    610                 615                 620                 


Phe Pro Thr Ala Lys Glu Pro Gln Lys Lys Cys Trp Cys Gly Ser Val 
625                 630                 635                 640 


His Arg Lys Lys Asp Pro Lys Arg Pro Arg Glu Arg Val His Ser Pro 
                645                 650                 655     


Cys His Ala Val Val Ile Glu Asn Leu Thr His Tyr Arg Pro Glu Glu 
            660                 665                 670         


Thr Arg Thr Arg Arg Glu Asn Arg Gln Leu Met Ser Trp Ser Ser Gly 
        675                 680                 685             


Lys Val Lys Lys Tyr Leu Ala Glu Ala Cys Gln Leu Asn Gly Leu His 
    690                 695                 700                 


Leu Arg Glu Val Asn Ala Ala Tyr Thr Ser Arg Gln Asp Ser Arg Thr 
705                 710                 715                 720 


Gly Ala Pro Gly Ile Arg Cys Gln Asp Val Pro Val Lys Glu Phe Met 
                725                 730                 735     


Arg Ser Pro Phe Trp Arg Glu Gln Val Ala Gln Ala Lys Lys Lys Gln 
            740                 745                 750         


Ala Glu Gly Lys Gly Asp Ala Arg Glu Arg Phe Leu Cys Asp Leu Asp 
        755                 760                 765             


Glu Gln Trp Lys Asn Arg Ser Glu Asp Glu Trp Lys Lys Ala Gly Pro 
    770                 775                 780                 


Val Arg Val Pro Leu Arg Gly Gly Glu Ile Phe Val Ser Ala Asp Gly 
785                 790                 795                 800 


Thr Ser Pro Thr Ala Lys Gly Leu His Ala Asp Leu Asn Ala Ala Ala 
                805                 810                 815     


Asn Ile Gly Leu Cys Ala Leu Thr Asp Pro Asp Trp Pro Gly Arg Trp 
            820                 825                 830         


Trp Tyr Val Pro Cys Asp Pro Ala Ser Phe Lys Pro Ile Met Asp Lys 
        835                 840                 845             


Val Glu Gly Ser Ala Ala Val Gln Pro Asp Gln Ala Leu Arg Gln Pro 
    850                 855                 860                 


Ala Gln Ala Gln Arg Gly Asp Ala Ala Arg Asp Arg Lys Lys Arg Gly 
865                 870                 875                 880 


Lys Val Gly Gly Arg Ser Arg Glu Val Val Asn Leu Trp Arg Asp Val 
                885                 890                 895     


Ser Ser Arg Pro Ile Ser Pro Asn Asp Ser Trp Gln Glu Phe Thr Pro 
            900                 905                 910         


Tyr Trp Asn Asp Val Gln Ala Arg Val Val Asn Ile Leu Arg Gln Ser 
        915                 920                 925             


Ala Gly Leu Thr Arg Gly Gln Gly Glu Pro 
    930                 935             


<210> 574
<211> 1140
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 574
Met Pro Leu Arg Ser Ile Asn Ile Lys Met Arg Leu Lys Arg Ala Ala 
1               5                   10                  15      


Glu Gly Arg Ala Leu Arg Gln Ser Leu Trp Leu Thr His Ser Val Val 
            20                  25                  30          


Asn Cys Ala Val Ala Glu Ile Glu Arg Val Leu Leu Leu Cys Arg Gly 
        35                  40                  45              


Arg Gly Tyr Trp Thr Gly Asp Asp Glu Pro Val Ser Ala Glu Thr Val 
    50                  55                  60                  


Gln Gln Gln Ala Leu Ala Phe Ala Arg Glu Thr Gln Ala Arg Asn Gly 
65                  70                  75                  80  


Gln Pro Gly Ile Gly Gly Asp Ala Glu Ile Leu Ala Ala Leu Arg Gly 
                85                  90                  95      


Leu Tyr Glu Ala Ile Val Pro Ser Val Asn Arg Asp Glu Gln Gly Arg 
            100                 105                 110         


Pro Leu Glu Gly Asn Ala Gln Ala Ala Gly Gly Phe Ala Gly Pro Met 
        115                 120                 125             


Met Asp Ala Glu Ser Glu Gly Phe Gln Ser Val Phe Asp Lys Ile Leu 
    130                 135                 140                 


Glu Pro Leu Pro Ser Trp Val Ala Lys Met Thr Gly Gly Thr Arg Gly 
145                 150                 155                 160 


Trp Glu Gln Glu Ser Val Gln Trp Leu Lys Ser Pro Glu Ser Glu Arg 
                165                 170                 175     


Leu Gln His Ala Ser Gly Ser Pro Pro Ala Trp Val Arg Arg Leu Arg 
            180                 185                 190         


Thr Gly Glu Pro Trp Gln Glu Ala Phe Val Gln Asp Gln Glu Asn Lys 
        195                 200                 205             


Arg Lys Glu Val Lys Gly Val Pro Ser Leu Ile Gln Arg Leu Lys Lys 
    210                 215                 220                 


Glu Leu Gly Leu Leu Pro Leu Met Arg Pro Pro Ile Thr Leu Gln Phe 
225                 230                 235                 240 


Glu Asp Lys Arg Ser Gly Leu Thr Pro Trp Asp Arg Leu Thr Leu Arg 
                245                 250                 255     


Leu Ala Val Ala His Leu Leu Ser Trp Glu Ser Trp Asn His Arg Ala 
            260                 265                 270         


Ala Asp Glu His Gly Arg Val Thr Glu Arg Leu Ala Arg Leu Glu Thr 
        275                 280                 285             


Glu Ala Ala Pro Leu Ala Ser Leu Ile Glu Gly Leu Arg Glu Tyr Glu 
    290                 295                 300                 


Lys Ile Arg His Glu Glu Leu Lys Arg Val Ala Gln Ala Asn Asp Glu 
305                 310                 315                 320 


Asn Pro Phe Arg Ile Gly Ala Arg Gly Val Arg Gly Trp Asp Arg Val 
                325                 330                 335     


Arg Glu Ala Trp Leu Gly Ala Thr Asp Asp Thr Lys Glu Gly Arg Phe 
            340                 345                 350         


Thr Ser Val Ala Ala Leu Gln Thr Lys Leu Gly Gly Arg Phe Gly Asp 
        355                 360                 365             


Pro Asp Leu Phe Arg Trp Leu Ala Glu Glu Gly Arg Glu His Leu Trp 
    370                 375                 380                 


Gly Glu His Asp Pro Leu Pro Ile Leu Ala Arg Leu Asn Ala Leu Ser 
385                 390                 395                 400 


Arg Leu Leu Arg Arg Lys Lys Asp His Ala Ile Tyr Thr Ala Pro Asp 
                405                 410                 415     


Ala Arg Leu His Pro Arg Trp Thr Ala Tyr Glu Ala Pro Gly Gly Gly 
            420                 425                 430         


Asn Leu Arg Asn Tyr Ser Phe Glu Ile Ser Gly Asn Asp Leu Ala Leu 
        435                 440                 445             


Arg Leu Pro Leu Leu Arg Arg Val Glu Ser Gly Leu Glu Glu Asp Ser 
    450                 455                 460                 


Gln Arg Ala Glu Ile Ala Leu Ala Pro Ser Gly Gln Phe Gln Ser Ala 
465                 470                 475                 480 


Ser Trp Lys Gly Asp Gly Lys Pro Asn Arg His Leu Thr Tyr Tyr Ser 
                485                 490                 495     


Ala His Glu Gln Phe Ser Ala Glu Leu Gly Gly Ala Glu Ile Leu Tyr 
            500                 505                 510         


Arg Arg Arg His Leu Glu Asn Arg Lys Val Lys Glu Leu Glu Gln Gly 
        515                 520                 525             


Asp Ile Gly Pro Val Trp Leu Lys Leu Val Leu Asp Val Gln Pro Asn 
    530                 535                 540                 


Ala Pro Glu Gly Trp Phe Thr Pro Arg Gly Arg Val Val Thr Pro Pro 
545                 550                 555                 560 


Thr Val His His Phe Asn Thr Ala Leu Val Asn Arg Ser Lys His Ala 
                565                 570                 575     


Pro Asp Leu Val Pro Gly Leu Arg Val Leu Ala Val Asp Leu Gly Val 
            580                 585                 590         


Arg Thr Phe Ala Ala Cys Ser Val Phe Glu Leu Val Gln Gly Glu Pro 
        595                 600                 605             


Gly Asn Gly Met Ala Phe Leu Ala Asp Gln Glu Arg Asp Leu Trp Ala 
    610                 615                 620                 


Arg His Glu Arg Ser Phe Leu Leu Pro Leu Pro Gly Glu Ala Val Asp 
625                 630                 635                 640 


Ser Gln Leu Leu Ala Ala Arg Arg Ala Ala Tyr Asn Gln Leu Gly Leu 
                645                 650                 655     


Leu Arg Arg Asp Leu Gly Arg Leu Lys Gly Ile Leu Arg Leu Ser Val 
            660                 665                 670         


Lys Glu Thr Ala Glu Asn Arg Cys Gly Ser Leu Glu Glu Leu Leu Ala 
        675                 680                 685             


Ser Leu Glu Asp Glu Trp Asn Arg Gly Asn Ala Pro Ala Ile Asp Val 
    690                 695                 700                 


Ala Ala Leu Leu Ser Ala Lys Gly Cys Leu Glu Met Pro Gln Pro Ala 
705                 710                 715                 720 


Trp Glu Ala Ala Ile Ala Gly Thr Tyr Gln Ala Ala Glu Arg Glu Leu 
                725                 730                 735     


Gly Asn Arg Val Arg Asp Trp Arg Arg Thr Thr Arg Pro Arg Thr Thr 
            740                 745                 750         


Gly Glu Asp Asp Arg Arg Gln Arg Arg Gly Tyr Ser Gly Gly Lys Ser 
        755                 760                 765             


Ala Trp Ala Val Glu Tyr Leu Asp Gln Val Arg Arg Leu Leu Gln Gly 
    770                 775                 780                 


Trp Ser Leu His Gly Arg Ser Tyr Ala Gln Ile Arg Arg Leu Asp Arg 
785                 790                 795                 800 


Glu Lys Met Gly Thr Phe Ala Ala Gly Leu Leu Asp His Ile Asn Ala 
                805                 810                 815     


Leu Lys Gln Asp Arg Val Lys Thr Gly Ser Asp Leu Ile Val Gln Ala 
            820                 825                 830         


Ala Arg Gly Tyr Leu Pro Thr Gly Lys Lys Gly Trp Ile Lys Gln Tyr 
        835                 840                 845             


Glu Pro Cys Arg Leu Ile Leu Phe Glu Asp Leu Ala Arg Tyr Arg Phe 
    850                 855                 860                 


Arg Thr Asp Arg Pro Arg Arg Glu Asn Ala Arg Leu Met Arg Trp Asn 
865                 870                 875                 880 


His Arg Gln Ile Leu Thr Glu Thr Glu Leu Gln Ala Glu Ile Phe Gly 
                885                 890                 895     


Leu Leu Ile Gly Thr Thr Gly Ala Gly Phe Ser Ser Arg Phe His Ala 
            900                 905                 910         


Arg Ser Gly Ala Pro Gly Cys Arg Thr Arg Leu Leu Thr Ala Glu Asp 
        915                 920                 925             


Leu Arg Ser Pro Thr Leu Ala Lys Gln Leu Glu Leu Leu Ala Glu Thr 
    930                 935                 940                 


Gln Gly Ile Asp Pro Lys Cys Phe Arg Pro Gly Met Gln Ile Pro Trp 
945                 950                 955                 960 


Asp Ser Gly Ala Asp Phe Val Thr Leu Asp Ser Glu Gly Lys Leu Val 
                965                 970                 975     


Gln Ile His Ala Asp Val Asn Ala Ala Gln Asn Leu Gln Arg Arg Phe 
            980                 985                 990         


Trp Thr Arg Phe Arg Asp Ala Tyr  Arg Ile Ser Ala Val  Glu Ile Lys 
        995                 1000                 1005             


Gln Asp  Gly Arg Thr Ser Trp  Tyr Pro Asp Arg Glu  Gly Val Arg 
    1010                 1015                 1020             


Leu Arg  Gly Ala Leu Ser Thr  Ile Val Gly Gly Asp  Gly Tyr Ala 
    1025                 1030                 1035             


Arg Leu  Val Ala Ala Asp Asp  Asp Asp Gly Phe Val  Leu Glu Lys 
    1040                 1045                 1050             


Val Thr  Arg Pro His Trp Arg  Arg Ala Ala Gly Ala  Gln Ala Glu 
    1055                 1060                 1065             


Ser Gly  Asp Asp Val Gly Leu  Asp Glu Val Ala Leu  Glu Met Ala 
    1070                 1075                 1080             


Glu Ala  Met Asp Thr Asp Leu  Glu Arg Gly Glu Gly  Arg Leu Val 
    1085                 1090                 1095             


Phe Phe  Arg Asp Pro Ser Gly  Ser Val Ile Arg Ala  Asp Arg Trp 
    1100                 1105                 1110             


Tyr Gln  Ala Lys Ala Phe Trp  Gly Gln Val Arg Ser  Arg Val Thr 
    1115                 1120                 1125             


Arg Ala  Leu Gly Leu Arg Arg  Pro Gly Ala Ser Ser  
    1130                 1135                 1140 


<210> 575
<211> 669
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 575
Met Leu Asp Lys Phe Ala Ser Leu Tyr Pro Val Thr Lys Thr Leu Arg 
1               5                   10                  15      


Phe Arg Leu Leu Pro Gln Gly Arg Thr Glu Glu Asn Met Gln Val Ala 
            20                  25                  30          


Lys Val Leu Glu Asn Asp Leu Glu Arg Ser Glu Ala Ala Ala Val Val 
        35                  40                  45              


Lys Gly Leu Ile Lys Lys Tyr His Leu Gln Phe Ile Ser Asp Thr Leu 
    50                  55                  60                  


Ser Gly Ser Thr Leu Ser Trp Gln Ala Leu Thr Glu Thr Leu Asp Lys 
65                  70                  75                  80  


Phe Lys Ala Asp His Thr Ala Thr Ala Glu Leu Asp Ser Ala Leu Ala 
                85                  90                  95      


Ala Tyr Arg Cys Lys Leu Ala Glu Leu Phe Thr Lys Ser Pro Lys Tyr 
            100                 105                 110         


Lys Val Met Ala Thr Pro Val Ser Ile Ile Lys Glu Ile Leu Lys Thr 
        115                 120                 125             


Glu Thr Asp Pro Glu Asn Ile Ala Ala Leu Asn Lys Leu Asn Gly Tyr 
    130                 135                 140                 


Thr Tyr Ile Ile Phe Asp Tyr Val Ser Thr Arg Met Leu Thr Tyr Ser 
145                 150                 155                 160 


Ala Asp Ala Lys Ala Thr Ser Leu Ala Tyr Arg Leu Val Asp Glu Asn 
                165                 170                 175     


Tyr Leu Arg Phe Tyr Gln Asp Ile Ser Ala Ala Ala Glu Ile Ser Ala 
            180                 185                 190         


Val Leu Glu Glu Ala Gly Phe Asp Asn Ala Glu Val Glu Ala Phe Ile 
        195                 200                 205             


Arg Thr Asp Tyr Asn Thr Cys Leu Thr Ser Glu Gly Ile Ala Ser Phe 
    210                 215                 220                 


Asn Ala Ala Ala Gly Ser Ile Asn Gln Phe Val Asn Val Leu Leu Gln 
225                 230                 235                 240 


Gln Asn Pro Val Leu Gln Ser Glu Pro Ala Leu Arg Arg His Leu Gln 
                245                 250                 255     


Pro Leu Tyr Lys Met Leu Leu Asp Glu Ala Glu Ser Lys Ile Ile Lys 
            260                 265                 270         


Phe Glu Asp Tyr Gly Gln Leu Arg Asp Ala Val Glu Asn Phe Arg Arg 
        275                 280                 285             


Asn Phe Gln Asp Leu Pro Gln Ser Leu Ile Asp Ile Phe Ala Gly Arg 
    290                 295                 300                 


Tyr Asp Tyr Ser Lys Ile Tyr Val Gly Tyr Lys Tyr Leu Asn Glu Ala 
305                 310                 315                 320 


Ser Ser Gln Ile Ala Gly Gly Tyr Asn Trp Lys Leu Leu Glu Asn Ala 
                325                 330                 335     


Leu Glu Asp Phe Tyr Ser Lys Pro Tyr Leu Val Asn Gly Lys Leu Pro 
            340                 345                 350         


Val Lys Tyr Lys Thr Val Val Asn Lys Lys Met Asn Gln Leu Ala Tyr 
        355                 360                 365             


Ser Phe Thr Glu Leu Gln Glu Ala Leu Asp Ala Gly Asp Ser Gly Ser 
    370                 375                 380                 


Ser Ile Thr Asp Leu Phe Gly Lys Tyr Ala Glu Leu His Ala Ala Tyr 
385                 390                 395                 400 


Ala Ala Ala Asp Gly Asn Val Phe Tyr Lys Glu Tyr Asp Arg Lys Ser 
                405                 410                 415     


Ile Ala Ser Leu Lys Asn Tyr Leu Asp Ala Val Asn Ala Ile Ala Arg 
            420                 425                 430         


Phe Ile Lys Ile Phe Ala Ala Pro Glu Val Tyr Val Lys Asp Glu Gly 
        435                 440                 445             


Phe Tyr Gly Ile Val Asp Gly Ala Ala Asp Lys Leu Arg Asp Phe Asp 
    450                 455                 460                 


Leu Leu Tyr Asn Met Val Arg Asn Tyr Ile Thr Lys Lys Pro Tyr Lys 
465                 470                 475                 480 


Lys Ser Lys Val Ala Leu Thr Phe Asn Ser Ser Ser Phe Gly Arg Gly 
                485                 490                 495     


Trp Asp Glu Asn Lys Ile Tyr Asp Glu Leu Thr Thr Ile Phe Thr Tyr 
            500                 505                 510         


Asn Gly Lys Tyr Tyr Leu Gly Val Ile Asn Lys Asn Asp Lys Pro Asp 
        515                 520                 525             


Leu Ala Ala Ala Val Ser Lys Asp Glu Gly Gly Tyr Lys Arg Met Val 
    530                 535                 540                 


Tyr Lys Thr Phe Asp Ile Val Lys Gln Leu Pro Arg Leu Ser Phe Thr 
545                 550                 555                 560 


Lys Ala Val Lys Ala His Phe Ala Glu Ser Asp Glu Asp Phe Ile Phe 
                565                 570                 575     


Asp Gly Pro Lys Phe Ala Lys Pro Leu Arg Val Pro Lys Glu Ile Tyr 
            580                 585                 590         


Leu Gln Ser Phe Thr Asp Asn Gly Asp Lys Leu Ala Asp Ser Ala Lys 
        595                 600                 605             


Lys Tyr Thr Lys Ala Tyr Leu Asp Met Ser Gly Asp Tyr Lys Gly Tyr 
    610                 615                 620                 


Tyr Glu Ala Ile Ile Lys Arg Ile Asp Tyr Thr Lys Glu Phe Leu Ser 
625                 630                 635                 640 


Ala Tyr Lys Ser Thr Ser Ile Tyr Asp Leu Ala Phe Leu Lys Pro Ala 
                645                 650                 655     


Gly Lys Ala Ala Gly Ser Leu Cys Trp Thr Arg His Ile 
            660                 665                 


<210> 576
<211> 1236
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 576
Met Ser Arg Ser Ile Phe Ser Pro Phe Thr Asn Leu Tyr Pro Ile Gln 
1               5                   10                  15      


Lys Thr Leu Arg Arg Glu Leu Lys Pro Leu Asn Glu Asn Phe Gln His 
            20                  25                  30          


Asp Pro Ala Leu Ser Ala Leu Arg Asn Ser Glu Ile Pro Gln Arg Asp 
        35                  40                  45              


Glu Gln Arg Glu Lys Asp Tyr Gln Ala Ile Lys Pro Leu Leu Asp Glu 
    50                  55                  60                  


Phe His Asn Gln Phe Ile Thr Glu Ser Leu His Ser Leu Glu Pro Gln 
65                  70                  75                  80  


Asp Arg Ser Asp Phe Ile Leu Phe Tyr Gln Thr Tyr Gln Lys Lys Lys 
                85                  90                  95      


Lys Asn Lys Ala Glu Ile Ser Glu Lys Glu Leu Lys Ser Leu Asp Glu 
            100                 105                 110         


Glu Phe Glu Ser Arg Thr Lys Ala Leu Arg Asn Ala Ile Gly Thr Ser 
        115                 120                 125             


Phe Ser Val Thr Ala Glu Leu Arg Lys Ser Asn Pro Asp Tyr Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Pro Phe Leu Thr Gln Lys Ser Tyr Lys Ile Leu Thr 
145                 150                 155                 160 


Glu Ala Gly Val Leu Trp Leu Leu Glu Lys Lys Tyr Thr Ser Asp Pro 
                165                 170                 175     


Glu Lys Leu Ala Leu Ile Arg Arg Phe Gly Asn Phe Phe Thr Tyr Phe 
            180                 185                 190         


Thr Gly Phe Asn Gln Asn Arg Glu Asn Tyr Tyr Ala Thr Asp Glu Lys 
        195                 200                 205             


Ser Thr Ala Val Ala Tyr Arg Ala Ile Asn Glu Asn Leu Leu Thr Phe 
    210                 215                 220                 


Ala Asn Asn Cys Glu Leu Phe Glu Lys Leu Ser Val Leu Ser Leu Ser 
225                 230                 235                 240 


Glu Leu Glu Lys Lys Thr Phe Asn Pro Asp Ser Tyr Ser Glu Tyr Leu 
                245                 250                 255     


Thr Gln Ser Gly Ile Val Phe Tyr Asn Glu Met Leu Ala Asn Ile Arg 
            260                 265                 270         


Ser Lys Ala Asn Leu Tyr Thr Gln Glu His Lys Ala Lys Leu Pro Gln 
        275                 280                 285             


Pro Lys Leu Leu Tyr Lys Gln Ile Trp Ser Pro Arg Gly Asp Thr Ile 
    290                 295                 300                 


Pro Phe Asp Leu Ile Ala Ser Glu Ala Glu Phe Gln Glu Thr Leu His 
305                 310                 315                 320 


Thr Met Ile Arg Glu Thr Asp Gln Arg Ile Pro Glu Phe Asn Lys Leu 
                325                 330                 335     


Leu Glu Gln Ile Phe Glu Glu Lys Val Asp Leu Ser Gln Ile Phe Phe 
            340                 345                 350         


Ser Lys Thr Ser Leu Asn Ile Ile Ser Asn Arg Tyr Phe Ser Ser Trp 
        355                 360                 365             


His Thr Leu Leu Glu Lys Gly Val Glu Leu Lys Leu Phe Lys Phe Lys 
    370                 375                 380                 


Lys Asn Asp Glu Glu Ser Phe Lys Leu Pro Ala Tyr Leu Ser Leu Ala 
385                 390                 395                 400 


Glu Leu Lys Glu Leu Leu Glu Ser Ala Pro Phe Gln Met Ala Glu Lys 
                405                 410                 415     


Ala Asp Ala Asp Glu Glu Lys His His Gln Ala Ser Leu Phe Lys Leu 
            420                 425                 430         


Gln Arg Glu Asn Leu His Leu Glu Lys Ser His Ser Asn Trp Glu Leu 
        435                 440                 445             


Leu Leu Lys Ser Met Lys Ser Asp Phe Glu Ser Phe Trp Thr Trp Glu 
    450                 455                 460                 


Gly Glu Phe Trp Ser Tyr Thr Leu Ala Lys Lys Ala Leu Gln Ser Leu 
465                 470                 475                 480 


Ser Ala Leu Glu Ser Thr Asn Gln Glu His Lys Asn Leu Ile Lys Met 
                485                 490                 495     


Leu Leu Asp Asn Ala Leu Tyr Ala Tyr Arg Met Leu Lys Trp Phe Lys 
            500                 505                 510         


Val Asp Thr Ser Lys Leu Gly Phe Val Pro Glu Gly Glu Phe Tyr Pro 
        515                 520                 525             


Ser Leu Asp Gln Leu Leu Gln Asp Tyr Pro Leu Pro Lys Trp Tyr Asp 
    530                 535                 540                 


Met Ile Arg Asn Tyr Leu Thr Arg Lys Thr Tyr Ser Gln Ala Lys Leu 
545                 550                 555                 560 


Lys Leu Asn Phe Asp Cys Ser Thr Leu Leu Asn Gly Arg Asp Lys Asn 
                565                 570                 575     


Lys Glu Ile Gln Asn Leu Ser Val Ile Leu Arg Lys Asp Gly Lys Phe 
            580                 585                 590         


Tyr Leu Ala Ile Met Lys Lys Asp Gln Asn Lys Phe Phe Glu Asn Ser 
        595                 600                 605             


Ala Leu Tyr Glu Gly Asn Leu Gly Thr Met Glu Lys Met Asp Tyr Lys 
    610                 615                 620                 


Leu Leu Pro Trp Ala Asn Lys Met Leu Pro Lys Cys Leu Met Pro Gly 
625                 630                 635                 640 


Ser Asp Lys Lys Lys Tyr Gly Ala Ser Asp Gln Val Leu Glu Leu Tyr 
                645                 650                 655     


Ala Lys Gly Ser Phe Lys Lys Ser Glu Lys Ser Phe Asn Leu Ala Asp 
            660                 665                 670         


Leu His Thr Leu Ile Asp Phe Tyr Lys Leu Ala Leu Pro Lys Tyr Glu 
        675                 680                 685             


Asp Trp Lys Val Phe Asn Phe Gln Phe Gln Ala Thr Glu Asn Tyr Gln 
    690                 695                 700                 


Asp Ile Ser Gln Phe Tyr Arg Glu Val Glu Gln Gln Gly Tyr Leu Leu 
705                 710                 715                 720 


Asn Trp Arg Lys Val Asn Glu Lys Leu Ile Lys Gln Gly Ile Lys Asp 
                725                 730                 735     


Trp Ser Leu Phe Leu Phe Gln Ile Ser Ser Lys Asp Phe Glu Gly Lys 
            740                 745                 750         


Ser Lys Thr Pro Asp Leu Gln Thr Leu Tyr Trp Gln Gln Leu Phe Glu 
        755                 760                 765             


Phe Ser Thr Asn Val Lys Leu Asn Gly Glu Ala Glu Ile Phe Phe Arg 
    770                 775                 780                 


Pro Trp Ser Met Lys Lys Glu Lys Lys Lys Leu Lys Val Asp Asn Tyr 
785                 790                 795                 800 


Asp Val Phe Lys His Lys Arg Tyr Thr Glu Asp Lys Ile Leu Phe His 
                805                 810                 815     


Val Pro Ile Thr Leu Trp Phe Gly Asn Asn Glu Val Ser Pro Ser Ala 
            820                 825                 830         


Pro Ser Lys Phe Asn Gln Lys Leu Asn Gln Glu Leu Ile Ile Pro His 
        835                 840                 845             


Phe Asp Asp Leu His Val Ile Gly Val Asp Arg Trp Glu Lys His Leu 
    850                 855                 860                 


Ala Phe Tyr Ser Val Val Ser Val Lys Thr Gly Lys Ile Val Lys Gln 
865                 870                 875                 880 


Gly Thr Leu Asn Leu Leu Asn Gly Thr Asp Tyr Glu Ala Lys Leu Ser 
                885                 890                 895     


Gln Lys Ala Glu Asn Arg Leu His Ala Arg Gln Asn Arg Asp Thr Ile 
            900                 905                 910         


Glu Lys Ile Ala Asp Leu Lys Asn Gly Tyr Ile Ser Gln Val Val Asn 
        915                 920                 925             


Lys Leu Val Glu Leu Val Leu Glu Tyr Asn Ala Val Ile Val Phe Glu 
    930                 935                 940                 


Asp Leu Asn Ala Gly Phe Lys Arg Gly Arg Gln Lys Ile Glu Gln Ser 
945                 950                 955                 960 


Val Tyr Gln Lys Leu Glu Leu Ala Leu Ala Lys Lys Leu Asn Phe Ile 
                965                 970                 975     


Val Lys Lys Glu Lys Ala Val Gly Glu Pro Trp Ser Val Thr Ser Ala 
            980                 985                 990         


Tyr Gln Leu Ala Pro Gln Ile Asn  Thr Phe Trp Asp Ile  Lys Trp Lys 
        995                 1000                 1005             


Gln Arg  Gly Ile Met Leu Tyr  Thr Arg Ala Asn Tyr  Thr Ser Val 
    1010                 1015                 1020             


Thr Asp  Pro Leu Thr Gly Trp  Arg Lys Gln Tyr Tyr  Phe Lys Lys 
    1025                 1030                 1035             


Gly Ser  Ser Glu Glu Met Lys  Ala Gln Phe Phe Lys  Ser Phe Lys 
    1040                 1045                 1050             


Asn Leu  Thr Arg Asp Ala Gly  Gln Glu Ala Tyr Ile  Phe Asp Asp 
    1055                 1060                 1065             


Gly Thr  Trp Leu Leu Tyr Ser  Asn Val Glu Arg Arg  Arg Gly Lys 
    1070                 1075                 1080             


Arg Gly  Asp His Arg Glu Arg  Thr Gln Ile Lys Tyr  Asp Pro Ser 
    1085                 1090                 1095             


Leu Glu  Leu Asp Thr Leu Phe  Ser Lys Tyr Gln Ile  Glu Lys Ser 
    1100                 1105                 1110             


Asp Ser  Leu Phe Asp Gln Leu  Lys Asn Arg Glu Leu  Pro Gln Thr 
    1115                 1120                 1125             


Phe Trp  Thr Ser Phe Phe Arg  Ile Ile Asp Leu Ile  Met Gln Ile 
    1130                 1135                 1140             


Arg Asn  Thr Asp Asp Glu Gly  Arg Asp Ile Ile Leu  Ser Pro Ile 
    1145                 1150                 1155             


Gly Asn  Pro Gln Glu Arg Phe  Asp Ser Arg Lys Arg  Tyr Asn Gln 
    1160                 1165                 1170             


Leu Pro  Arg Asp Glu Lys Gly  Gly Ile Ile Glu Glu  Ser Ala Phe 
    1175                 1180                 1185             


Glu Tyr  Pro Thr Ser Trp Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1190                 1195                 1200             


Arg Lys  Gly Val Met Met Leu  Glu Arg Ile Lys Glu  Asn Pro Glu 
    1205                 1210                 1215             


Lys Pro  Asp Leu Leu Ile Arg  Asp Ala Glu Trp Asp  Lys Lys Ile 
    1220                 1225                 1230             


Thr Arg  Lys 
    1235     


<210> 577
<211> 1333
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 577
Met Lys Asn Phe Gln Asp Phe Thr Asn Leu Tyr Glu Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Ile Trp Gly Thr Lys Lys Leu Ile Glu 
            20                  25                  30          


Glu Lys Asn Ile Leu Lys Leu Asp Lys Lys Lys Arg Glu Asn Tyr Glu 
        35                  40                  45              


Lys Val Lys Pro Tyr Phe Asn Lys Ile His Gln Glu Phe Ile Asn Phe 
    50                  55                  60                  


Ala Leu Arg Asn Pro Asn Phe Asp Phe Ser Gln Phe Glu Glu Lys Tyr 
65                  70                  75                  80  


Leu Asn Trp Leu Lys Asp Lys Lys Asn Lys Asp Leu Leu Lys Glu Lys 
                85                  90                  95      


Glu Ser Ile Asp Lys Ile Phe Leu Glu Lys Ile Trp Lys Leu Phe Glu 
            100                 105                 110         


Asn Ser Val Lys Asp Phe Leu Lys Glu Asn Gly Phe Glu Ser Ile Val 
        115                 120                 125             


Lys Ser Glu Asp Gln Asn Leu Lys Phe Phe Arg Arg Lys Glu Ile Phe 
    130                 135                 140                 


Glu Val Leu Gln Glu Lys Tyr Gly Ser Glu Leu Glu Thr Gln Met Val 
145                 150                 155                 160 


Asn Lys Asp Trp Glu Ile Lys Ser Ile Phe Asn Gly Trp Glu Lys Trp 
                165                 170                 175     


Leu Trp Tyr Phe Asp Lys Phe Phe Asn Thr Arg Asp Asn Phe Tyr Lys 
            180                 185                 190         


Thr Asp Trp Thr Ser Thr Ala Ile Ala Thr Arg Ile Ile Lys Asp Asn 
        195                 200                 205             


Leu Lys Ile Phe Leu Glu Asn Thr Ile Ile Phe Glu Lys Val Lys Asn 
    210                 215                 220                 


Lys Lys Ile Asp Phe Ser Glu Val Glu Lys Asn Phe Ser Val Ser Ile 
225                 230                 235                 240 


Asp Thr Phe Phe Glu Ile Asn Asn Phe Asn Asn Cys Phe Leu Gln Asp 
                245                 250                 255     


Trp Ile Asp Phe Tyr Asn Lys Val Ile Trp Gly Glu Thr Leu Glu Asn 
            260                 265                 270         


Trp Glu Lys Leu Lys Trp Leu Asn Glu Ile Ile Asn Lys Tyr Arg Gln 
        275                 280                 285             


Asp Thr Gly Glu Lys Ile Pro Tyr Phe Lys Lys Leu Gln Lys Gln Ile 
    290                 295                 300                 


Leu Ser Glu Lys Asp Trp Val Phe Ile Asp Lys Ile Glu Asp Asp Gly 
305                 310                 315                 320 


Gly Phe Tyr Glu Val Leu Lys Asn Phe Tyr Lys Asn Ala Ala Glu Lys 
                325                 330                 335     


Glu Trp Phe Leu Lys Asn Ile Phe Glu Asn Phe Tyr Thr Ile Ser Asp 
            340                 345                 350         


Lys Asn Leu Glu Lys Ile Tyr Phe Asn Lys Ile Ala Phe Asn Thr Ile 
        355                 360                 365             


Ser His Lys Phe Trp Ser Ala Leu Glu Phe Glu Arg Ile Leu Tyr Glu 
    370                 375                 380                 


Glu Met Lys Lys Glu Lys Ala Asp Trp Ile Lys Phe Glu Lys Lys Glu 
385                 390                 395                 400 


Asn Lys Tyr Lys Phe Pro Asp Phe Ile Gln Ile Ile Phe Ile Lys Arg 
                405                 410                 415     


Ser Leu Glu Asn Tyr Asp Ser Glu Asn Leu Phe Trp Lys Glu Arg Tyr 
            420                 425                 430         


Tyr Lys Ser Glu Glu Asn Val Asp Trp Phe Leu Glu Lys Asn Asn Asn 
        435                 440                 445             


Asn Ile Trp Glu Gln Phe Cys Lys Ile Leu Asn Phe Glu Phe Leu Asn 
    450                 455                 460                 


Ile Leu Lys Arg Arg Ile Ile Asp Glu Ala Trp Glu Glu Tyr Glu Val 
465                 470                 475                 480 


Trp Phe Glu Ile Ser Lys Asn Ile Leu Trp Glu Lys Leu Glu Asn Phe 
                485                 490                 495     


Glu Leu Asn Gln Glu Asn Lys Trp Ile Ile Lys Asp Phe Ala Asp Tyr 
            500                 505                 510         


Ser Leu Ala Leu Tyr Ser Phe Trp Lys Tyr Phe Ala Val Glu Lys Trp 
        515                 520                 525             


Arg Asn Trp Asp Leu Asn Ile Asp Ile Ser Asp Asp Phe Tyr Gly Trp 
    530                 535                 540                 


Glu Asp Trp Tyr Ile Glu Lys Phe Tyr Asn Thr Gly Tyr Asp Glu Ile 
545                 550                 555                 560 


Val Lys Pro Tyr Asn Leu Met Arg Asn Tyr Ile Ser Lys Lys Pro Trp 
                565                 570                 575     


Glu Asp Ser Lys Lys Trp Lys Ile Asn Phe Glu Thr Ser Ser Leu Leu 
            580                 585                 590         


Ser Trp Trp Asp Lys Asn Leu Glu Ser Asn Trp Ser Tyr Ile Phe Gln 
        595                 600                 605             


Lys Trp Asn Lys Tyr Tyr Ile Trp Ile Ile Asn Trp Ser Lys Pro Ala 
    610                 615                 620                 


Lys Glu Val Leu Glu Lys Leu Tyr Ser Trp Asn Gly Glu Lys Ile Lys 
625                 630                 635                 640 


Arg Phe Ile Tyr Asp Phe Gln Lys Pro Asp Asn Lys Asn Thr Pro Arg 
                645                 650                 655     


Met Phe Ile Arg Ser Lys Lys Asp Ser Phe Ser Pro Ala Val Gly Lys 
            660                 665                 670         


Tyr Asn Leu Pro Val Glu Asp Ile Leu Glu Ile Tyr Asp Asn Trp Leu 
        675                 680                 685             


Phe Lys Thr Glu Asn Lys Asp Asn Ser Asn Tyr Lys Glu Ser Leu Ser 
    690                 695                 700                 


Lys Leu Ile Asp Tyr Phe Lys Leu Gly Phe Ser Lys His Glu Ser Phe 
705                 710                 715                 720 


Lys His Phe Asn Phe Val Trp Lys Asp Ser Lys Glu Tyr Glu Asn Ile 
                725                 730                 735     


Ala Asp Phe Tyr Arg Asp Val Glu Lys Ser Cys Tyr Gln Ile Thr Ser 
            740                 745                 750         


Glu Phe Leu Asp Phe Glu Glu Leu Lys Lys Leu Thr Phe Lys Lys His 
        755                 760                 765             


Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Glu Leu Asp Glu Ser 
    770                 775                 780                 


Leu Gln Lys Asn Trp Tyr Asn Phe Arg Asp Glu Trp Gln Lys Asn Ile 
785                 790                 795                 800 


His Thr Lys Tyr Phe Glu Ala Leu Phe Leu Glu Glu Asn Ile Leu Arg 
                805                 810                 815     


Lys Ser Trp Ala Val Phe Lys Leu Ser Trp Gly Trp Glu Val Phe Phe 
            820                 825                 830         


Arg Lys Glu Ser Ile Lys Ala Glu Lys Glu Lys Arg Lys Asn Ile Glu 
        835                 840                 845             


Val Thr Lys Asn Arg Arg Tyr Thr Glu Glu Lys Tyr Phe Leu His Phe 
    850                 855                 860                 


Pro Ile Gln Val Asn Phe Lys Asn Glu Ile Ser Trp Asn Phe Asn Gln 
865                 870                 875                 880 


Glu Ile Asn Lys Phe Leu Ala Asn Asn Pro Asp Ile Asn Val Ile Trp 
                885                 890                 895     


Ile Asp Arg Trp Glu Lys His Leu Ala Tyr Phe Ser Val Ile Asn Gln 
            900                 905                 910         


Lys Trp Glu Ile Leu Glu Ser Trp Ser Phe Asn Lys Ile Glu Asn Tyr 
        915                 920                 925             


Asn Lys Asn Trp Glu Lys Leu Leu Phe Pro Glu Arg Glu Ile Lys Glu 
    930                 935                 940                 


Ile His Lys Asp Trp Ser Leu Ile Asp Leu Glu Leu Val Glu Thr Trp 
945                 950                 955                 960 


Arg Lys Val Asp Tyr Val Asp Tyr Lys Leu Leu Leu Glu Tyr Lys Glu 
                965                 970                 975     


Arg Lys Arg Leu Leu Gln Arg Gln Ser Trp Lys Glu Val Glu Gln Ile 
            980                 985                 990         


Lys Asp Leu Lys Lys Trp Tyr Ile  Ser Ala Leu Val Arg  Lys Ile Ala 
        995                 1000                 1005             


Asp Leu  Ile Ile Lys His Asn  Ala Ile Val Ile Phe  Glu Asp Leu 
    1010                 1015                 1020             


Asn Phe  Arg Phe Lys Gln Ile  Arg Gly Trp Ile Glu  Lys Ser Ile 
    1025                 1030                 1035             


Tyr Gln  Gln Leu Glu Lys Ala  Leu Ile Asp Lys Leu  Asn Phe Leu 
    1040                 1045                 1050             


Val Asn  Lys Asn Glu Ile Asn  Leu Glu Lys Ala Gly  Ser Ile Leu 
    1055                 1060                 1065             


Lys Ala  Tyr Gln Leu Thr Val  Pro Val Asp Ser Leu  Lys Glu Ile 
    1070                 1075                 1080             


Trp Lys  Gln Thr Trp Val Ile  Phe Tyr Thr Glu Ala  Ala Tyr Thr 
    1085                 1090                 1095             


Ser Lys  Ile Asp Pro Ile Lys  Trp Trp Arg Pro Asn  Leu Tyr Leu 
    1100                 1105                 1110             


Lys Lys  Gln Asn Ala Glu Ile  Asn Lys Glu Asn Ile  Leu Lys Phe 
    1115                 1120                 1125             


Asp Asn  Ile Ile Phe Asn Ser  Lys Glu Asn Arg Phe  Glu Phe Thr 
    1130                 1135                 1140             


Tyr Asp  Leu Lys Lys Phe Phe  Trp Lys Asp Ser Lys  Phe Pro Ala 
    1145                 1150                 1155             


Lys Thr  Val Asn Thr Val Cys  Ser Cys Val Glu Arg  Phe Lys Trp 
    1160                 1165                 1170             


Asn Arg  Asn Leu Asn Asn Asn  Lys Trp Gly Tyr Ile  His Tyr Glu 
    1175                 1180                 1185             


Asn Leu  Thr Asp Trp Lys Leu  Ala Asn Lys Glu Gln  Lys Glu Asp 
    1190                 1195                 1200             


Glu Phe  Ser Asn Phe Lys Glu  Leu Phe Glu Lys Tyr  Phe Ile Asp 
    1205                 1210                 1215             


Ile Asn  Trp Asn Ile Leu Glu  Gln Ile Lys Asn Leu  Asp Thr Lys 
    1220                 1225                 1230             


Asn Asn  Glu Lys Phe Phe Ser  Ser Phe Ile Asp Leu  Phe Thr Leu 
    1235                 1240                 1245             


Val Cys  Gln Ile Arg Asn Thr  Asn Gln Asn Ala Lys  Trp Asp Glu 
    1250                 1255                 1260             


Asn Asp  Phe Ile Leu Ser Pro  Val Glu Pro Phe Phe  Asp Ser Arg 
    1265                 1270                 1275             


Lys Ser  Gln Asn Phe Trp Lys  Ser Leu Pro Lys Asn  Trp Asp Glu 
    1280                 1285                 1290             


Asn Trp  Ala Phe Asn Ile Ala  Arg Lys Gly Leu Ile  Ile Leu Asn 
    1295                 1300                 1305             


Arg Ile  Ser Glu Asn Pro Glu  Lys Pro Asp Leu Leu  Ile Phe Asn 
    1310                 1315                 1320             


Ala Asp  Trp Asp Asn Phe Ala  Arg Asn Ile 
    1325                 1330             


<210> 578
<211> 926
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 578
Arg Pro Gly Ala Ser Ala Ala Leu Ser Leu Thr Pro Leu Lys Thr Leu 
1               5                   10                  15      


Phe Ser Glu Asn Phe Ser Ser Phe Met Cys Gly Asn Trp Gln Ile Ile 
            20                  25                  30          


Asn Asp Ser Leu Lys Thr Tyr Tyr Asn Glu Asn Ile Lys Ser Lys Gly 
        35                  40                  45              


Lys Ala Lys Glu Glu Lys Val Lys Lys Ala Ile Lys Ala Ile Glu Tyr 
    50                  55                  60                  


Lys Ser Leu Ala Asp Ile Asn Gln Leu Val Glu Arg Tyr Asn Asn Asp 
65                  70                  75                  80  


Glu Leu Asn Arg Lys Ala Glu Glu Tyr Ile Ser Ala Ile Asn Glu Lys 
                85                  90                  95      


Ile Lys Asp Leu Asp Val Asn Glu Ile Glu Tyr Asp Glu Lys Ile Asn 
            100                 105                 110         


Leu Ile Glu Asn Glu Thr Lys Ser Glu Glu Ile Lys Ser Lys Leu Asp 
        115                 120                 125             


Ser Ile Met Glu Ile Met His Trp Thr Lys Met Phe Ile Ile Glu Glu 
    130                 135                 140                 


Glu Ile Glu Lys Asp Val Asn Phe Tyr Asn Glu Ile Glu Glu Ile Tyr 
145                 150                 155                 160 


Asp Glu Leu Gln Pro Leu Val Thr Ile Tyr Asn Arg Ile Arg Asn Tyr 
                165                 170                 175     


Val Thr Gln Lys Pro Tyr Ser Glu Glu Lys Ile Lys Leu Asn Phe Gly 
            180                 185                 190         


Ile Pro Thr Leu Ala Asn Gly Trp Ser Lys Thr Lys Glu Tyr Asp Asn 
        195                 200                 205             


Asn Ala Ile Ile Met Ile Arg Asp Gly Lys Tyr Tyr Leu Gly Ile Phe 
    210                 215                 220                 


Asn Ala Lys Asn Lys Pro Asp Lys Lys Ile Met Glu Gly His Gln Ser 
225                 230                 235                 240 


Glu Glu Asn Gly Asp Tyr Lys Lys Met Ile Tyr Arg Leu Leu Pro Gly 
                245                 250                 255     


Pro Asn Lys Met Leu Pro Lys Val Phe Met Ser Lys Thr Gly Ile Ala 
            260                 265                 270         


Glu Tyr Lys Pro Ser Gln Tyr Ile Leu Glu Cys Tyr Glu Gln Asn Lys 
        275                 280                 285             


His Ile Lys Ser Asp Lys Asn Phe Asp Ile Lys Phe Cys Arg Asp Leu 
    290                 295                 300                 


Ile Asp Phe Phe Lys Thr Ser Ile Asn Arg His Pro Glu Trp Ser Lys 
305                 310                 315                 320 


Phe Asn Phe Lys Phe Ser Glu Thr Ser Glu Tyr Glu Asp Ile Ser Thr 
                325                 330                 335     


Phe Tyr Arg Glu Val Glu Lys Gln Gly Tyr Lys Ile Glu Trp Thr Tyr 
            340                 345                 350         


Ile Ser Glu Lys Glu Ile Lys Glu Leu Asp Glu Asn Gly Gln Leu Tyr 
        355                 360                 365             


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Lys Ser Lys Gly Lys 
    370                 375                 380                 


Glu Asn Leu His Thr Met Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn 
385                 390                 395                 400 


Leu Lys Asn Ile Val Leu Lys Leu Asn Gly Glu Ala Glu Val Phe Phe 
                405                 410                 415     


Arg Lys Ser Ser Ile Lys Lys Pro Ile Ile His Lys Lys Gly Ser Val 
            420                 425                 430         


Leu Val Asn Lys Thr Tyr Asn Glu Asn Gly Glu Arg Lys Ser Ile Pro 
        435                 440                 445             


Glu Glu Gln Tyr Thr Glu Ile Tyr Lys Tyr Leu Asn Ser Ile Gly Thr 
    450                 455                 460                 


Asn Glu Leu Ser Glu Lys Ser Lys Lys Leu Met Glu Glu Gly Lys Val 
465                 470                 475                 480 


Glu Tyr Tyr Lys Ala Asn Tyr Asp Ile Val Lys Asp Tyr Arg Tyr Ser 
                485                 490                 495     


Val Asp Lys Phe Phe Ile His Leu Pro Met Thr Ile Asn Phe Lys Ala 
            500                 505                 510         


Ala Gly Phe Ser Pro Ile Asn Asn Ile Ala Leu Lys Asn Ile Ala Leu 
        515                 520                 525             


Lys Asp Asp Met His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu 
    530                 535                 540                 


Ile Tyr Val Ser Val Ile Asp Thr Lys Gly Asn Ile Val Glu Gln Arg 
545                 550                 555                 560 


Asn Phe Asn Ile Val Asn Gly Ile Asp Tyr Lys Glu Lys Leu Lys Gln 
                565                 570                 575     


Lys Glu Leu Asp Arg Asp Asn Ala Arg Lys Asn Trp Lys Glu Ile Gly 
            580                 585                 590         


Lys Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ser Leu Val Val His Glu 
        595                 600                 605             


Ile Ala Lys Leu Val Val Lys Tyr Asn Ala Ile Ile Thr Met Glu Asp 
    610                 615                 620                 


Leu Asn Gln Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Arg Gln Val 
625                 630                 635                 640 


Tyr Gln Lys Phe Glu Thr Met Leu Ile Asn Lys Leu Asn Tyr Leu Val 
                645                 650                 655     


Asp Lys Asp Leu Ala Val Asp Gln Glu Gly Gly Leu Leu Arg Gly Tyr 
            660                 665                 670         


Gln Leu Thr Tyr Ile Pro Glu Ser Leu Lys Val Leu Gly Arg Gln Cys 
        675                 680                 685             


Gly Tyr Ile Phe Tyr Val Pro Ala Ala Tyr Thr Ser Lys Ile Asp Pro 
    690                 695                 700                 


Thr Thr Gly Phe Val Ala Ile Phe Asn Tyr Lys Gly Met Thr Asp Lys 
705                 710                 715                 720 


Asp Phe Val Thr Ser Phe Asp Ser Ile Lys Tyr Asp Asp Glu Arg Gly 
                725                 730                 735     


Leu Phe Ala Phe Glu Phe Asp Tyr Glu Asn Phe Val Thr His Lys Val 
            740                 745                 750         


Glu Met Ala Arg Asn Lys Trp Thr Val Tyr Thr Tyr Gly Glu Arg Ile 
        755                 760                 765             


Lys Arg Lys Phe Lys Asn Gly Ser Trp Asp Thr Ala Glu Lys Val Asp 
    770                 775                 780                 


Leu Thr Tyr Gln Met Arg Ser Ile Leu Glu Lys Tyr Glu Ile Glu Tyr 
785                 790                 795                 800 


Asn Lys Gly Gln Asp Ile Leu Glu Gln Ile Glu Glu Leu Asp Glu Lys 
                805                 810                 815     


Ala Gln Asn Gly Ile Cys Lys Glu Ile Lys Tyr Leu Val Lys Asp Ile 
            820                 825                 830         


Val Gln Met Arg Asn Ser Leu Pro Asp Asn Ala Ala Glu Asp Tyr Asp 
        835                 840                 845             


Ala Ile Ile Ser Pro Val Ile Asn Asn Asn Gly Glu Phe Phe Asp Ser 
    850                 855                 860                 


Thr Arg Gly Asp Glu Asp Lys Pro Leu Asp Ala Asp Ala Asn Gly Ala 
865                 870                 875                 880 


Tyr Cys Ile Ala Leu Lys Gly Leu Tyr Glu Val Met Gln Ile Lys Lys 
                885                 890                 895     


Asn Trp Asn Glu Glu Thr Glu Phe Pro Arg Lys Glu Leu Lys Ile Arg 
            900                 905                 910         


His Gln Asp Trp Leu Asp Phe Ile Gln Asn Lys Arg Tyr Leu 
        915                 920                 925     


<210> 579
<211> 1466
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 579
Met Gln Cys Gly Ser Leu Arg His Asn Ser Lys Ser Leu Asp Ser Ala 
1               5                   10                  15      


Leu Ala Tyr Pro Ala Arg Leu Thr Thr Gly Gly Asn Glu Gly Lys Thr 
            20                  25                  30          


Ser Glu Ala His Ile Glu Asn Asp Ser Leu Pro Glu Ile Thr Arg Arg 
        35                  40                  45              


Pro Ser Arg Leu Ala Arg Asp Phe Ala Pro Ser Asn Pro Phe Pro Phe 
    50                  55                  60                  


Met Lys Arg Ile Tyr Gln Gly Gln Ile Thr Gly Met Gln Phe His Gly 
65                  70                  75                  80  


Ala Ala Gly Glu Gln Ala Val Pro Ala Asn Gln Asn Trp Glu Gln Ala 
                85                  90                  95      


Leu Trp Asp His His Gly Leu Phe His Asp Ala Val Asn Tyr Tyr Leu 
            100                 105                 110         


Val Cys Leu Leu Ala Leu Ala Arg Pro Gly Asn Pro Val Tyr Ala Ile 
        115                 120                 125             


Arg Glu Lys Leu Asp Ala His Asn Gly Ala Glu Pro Asp Glu Leu Met 
    130                 135                 140                 


Val Trp Arg Thr Phe Arg Arg Arg Gly Cys Asn Arg Pro Gly Leu Arg 
145                 150                 155                 160 


Asp Ser Val Ala Lys Tyr Leu Thr Pro Gly Asn Asp Glu Pro Thr Thr 
                165                 170                 175     


Glu Glu Cys Phe Ala Ala Val Leu Ala Gly Asn Pro Leu Gly Ala Thr 
            180                 185                 190         


Glu Glu Gly Arg Ala Ile Leu Asn Glu Gly Leu Ala Gln Leu Leu Gly 
        195                 200                 205             


Lys Cys Thr Gly Glu Ser Gly Cys Arg Asn Ser Ala Lys Glu Tyr Leu 
    210                 215                 220                 


Pro Arg Phe Thr Lys Pro Asp Phe Lys Gly Asn Phe Glu Glu Asp Thr 
225                 230                 235                 240 


Ala Arg Leu Asn Arg Ala Glu Ala Ser Lys Arg Leu Pro Phe Tyr Leu 
                245                 250                 255     


His Asp Pro Ala Thr Thr Pro Asn Ser Pro Ala Leu Asp Glu Phe Gly 
            260                 265                 270         


Val Leu Ser Ile Ala Leu Pro Asn Pro Lys Arg Ala Glu Leu Thr Gly 
        275                 280                 285             


Ala Glu Ala Arg Asp Lys Leu Leu Glu Phe Ser Arg Glu Trp Ser Ala 
    290                 295                 300                 


Arg Leu Pro Asp Gly Ser Ala Asp Trp Arg Arg Leu Glu Ala Lys Ile 
305                 310                 315                 320 


Thr Ala Leu Gly Asp Ser Leu Ala Ile Pro Gly Tyr Thr Ser Gly Ser 
                325                 330                 335     


Ala Lys Gly Glu Asn Arg Phe Gln Leu Tyr Ala Met Phe Leu Phe Cys 
            340                 345                 350         


Phe Val Glu Lys Ser Asp Phe Thr Leu Gly Leu Leu Arg Gln Thr Thr 
        355                 360                 365             


Arg Arg Pro Val Glu Gly Glu Glu Pro Pro Pro Arg Ser Asn His Ser 
    370                 375                 380                 


Ala Thr Ala Gly Asp Pro Ile Arg Ile Ala Arg Gly Gly Arg Gly Tyr 
385                 390                 395                 400 


Val Phe Arg Ala Phe Thr Ser Leu Lys Gln Trp Gly Gly Asp Thr Gly 
                405                 410                 415     


Gly Asp Leu Lys Trp Pro Lys Phe Asp Met Ala Ala Phe Cys Glu Ala 
            420                 425                 430         


Leu Lys Ala Leu His Gln Val Glu Ala Lys Ala Lys Gln Arg Ala Glu 
        435                 440                 445             


Glu Arg Ser Lys Lys Gln Ala Leu Leu Asp Tyr Gln Arg Gly Arg Ile 
    450                 455                 460                 


Arg Arg Phe Lys Pro Thr Ala Asn Ser Glu Asp Ala Thr Pro Pro Pro 
465                 470                 475                 480 


Val Leu Ala Gly Asp Pro Arg Ile Ser Arg Leu Glu Gln Leu Leu Asn 
                485                 490                 495     


Thr Asp Leu Gln Asp Glu Tyr Glu Met Ser Glu Gly Val Ala Val Ala 
            500                 505                 510         


Tyr Gly Leu His Pro Arg Thr Ile Arg Gly Phe Arg Glu Ile Arg Lys 
        515                 520                 525             


Arg Trp Ile Ser Ala Val Gly Asn Ala Pro Phe Ser Glu Ala Ala Arg 
    530                 535                 540                 


Ala Thr Leu Ile Ala Cys Val Arg Ser Phe Gln Ser Glu Asn Pro Gly 
545                 550                 555                 560 


Thr Val Gly Ser Ala Arg Leu Phe Glu Ala Leu Ala Glu Glu Ser Asn 
                565                 570                 575     


Trp Ile Ile Trp Arg Glu Pro Ser Ala Ala Glu Gln Gln Ser Trp Arg 
            580                 585                 590         


Glu Asn Ala Asp Leu Pro Glu Ser Ala Glu Phe Ala Leu Asp Pro Leu 
        595                 600                 605             


Gln Ala Leu Thr Asp Glu Arg Glu Leu Lys Asp Glu Ile Glu Arg Leu 
    610                 615                 620                 


Ser Gly Pro Ile Arg Phe Thr Pro Ala Asp Ala Glu His Ser Arg Arg 
625                 630                 635                 640 


Gln Phe Tyr Phe Ser Asp Val Ser Gln Ile Asp Lys Arg Asn Arg Phe 
                645                 650                 655     


Arg Pro Arg Leu Asn Glu Val Glu Val Glu Leu Ala Val Arg Pro Asn 
            660                 665                 670         


Gly His Trp Thr Asn Val Trp Val Thr Leu Gln Tyr Ser Ala Pro Arg 
        675                 680                 685             


Leu Leu Arg Asp Gln Leu Pro Thr Ala Asp Glu Ala Gly Gly Gly Trp 
    690                 695                 700                 


Gln Gln Ala Met Met Ala Ala Leu Asn Leu Arg Ala Pro Leu Lys Lys 
705                 710                 715                 720 


Gly Gly Glu Ala Val Ser Phe Ala Asp Cys Ala Ala Leu Ser Leu Met 
                725                 730                 735     


Pro Asp Ile Ser Pro Asp Gly Glu Lys Arg Leu Leu Leu Asn Phe Pro 
            740                 745                 750         


Val Glu Leu Asp Gly Glu Ala Ile Ala Asn Gln Leu Gly Arg Ser Lys 
        755                 760                 765             


Arg Trp Glu Thr Leu Gln Phe Gly Gly Ala Asp Asp Glu Ser Tyr Trp 
    770                 775                 780                 


Leu Arg Trp Pro Lys Thr Trp Ile Asp Glu Thr Lys Val Arg Arg Lys 
785                 790                 795                 800 


Ala Ala Pro Pro Lys Trp Trp Leu Ser Lys Glu Pro Phe Ser Val Leu 
                805                 810                 815     


Gly Val Asp Leu Gly Gln Arg Asp Ala Ala Ala Cys Ala Leu Val Gln 
            820                 825                 830         


Val Ser Pro Gly Asn Cys Pro Thr Gly Val Cys Arg His Val Gly Ser 
        835                 840                 845             


Ala Asp Gly Val Asp Trp Trp Ala Thr Val Arg Ser Met Asn Met Leu 
    850                 855                 860                 


Arg Leu Pro Gly Glu Asn Ala Lys Val Met Arg Asp Gly Arg Phe Gln 
865                 870                 875                 880 


Glu Glu Leu Ser Gly Ser Arg Gly Arg Ser Ala Ser Ile Asp Glu Leu 
                885                 890                 895     


Lys Glu Ala Gly Asp Ile Cys Ala Arg Leu Gly Phe Val Ala Asp Thr 
            900                 905                 910         


Ile Leu Gly Ala Asn Gly Arg Ala Leu Ser Phe Pro Glu Leu Asn Asp 
        915                 920                 925             


Arg Leu Leu Phe Ser Leu Arg Ser Ala Gln Ser Arg Leu Ala Arg Leu 
    930                 935                 940                 


Gln Ser Trp Ser Cys Val Ala His Ala Asp Val Pro Pro Ala Arg Arg 
945                 950                 955                 960 


Glu Gly Ile Leu Arg Asp Ile Ser Glu Ala Lys Asp Asp Pro Leu Gly 
                965                 970                 975     


Leu Lys Pro Leu Ala Thr Ala Gly Asn Leu Glu Ala Ile Ala Ser Thr 
            980                 985                 990         


Leu Arg Glu Val Ile Leu Gln Glu  Arg Thr Ser Ile Ser  Ala Gln Leu 
        995                 1000                 1005             


Val Arg  Val Ala Asp Arg Ile  Leu Pro Leu Arg Gly  Arg Arg Trp 
    1010                 1015                 1020             


Glu Trp  Val Ala Arg Pro Glu  Ser Pro Ser Asn His  Met Leu Arg 
    1025                 1030                 1035             


Ala Thr  Ala Pro Asp Thr Asp  Pro Arg Arg Lys Leu  Val Ala Gly 
    1040                 1045                 1050             


Gln Arg  Gly Leu Ser Leu Ala  Arg Val Glu Gln Leu  Glu Ser Leu 
    1055                 1060                 1065             


Arg Gln  Arg Cys Gln Ser Leu  Asn Arg Ala Leu Met  Gln Val Pro 
    1070                 1075                 1080             


Gly Thr  Pro Ser Lys Leu Gly  Arg Arg Ser Arg Gly  Val Glu Leu 
    1085                 1090                 1095             


Pro Asp  Pro Cys Pro Asp Leu  Leu Asp Arg Leu Asp  Ala Leu Lys 
    1100                 1105                 1110             


Glu Gln  Arg Val Asn Gln Thr  Ala His Leu Ile Leu  Ala Gln Ala 
    1115                 1120                 1125             


Leu Gly  Val Arg Leu Arg Ile  His Gln Val Ser Gly  Pro Gln Arg 
    1130                 1135                 1140             


Thr Arg  Ser Asp Ser His Gly  Glu Tyr Glu Arg Ile  Pro Gly Arg 
    1145                 1150                 1155             


Glu Pro  Val Asp Phe Leu Val  Leu Glu Asn Leu Asp  Arg Tyr Leu 
    1160                 1165                 1170             


Ala Ser  Gln Gly Arg Ser Arg  Ser Glu Asn Ser Arg  Leu Met Lys 
    1175                 1180                 1185             


Trp Cys  His Arg Ala Ile Leu  Leu Lys Leu Lys Gln  Leu Cys Glu 
    1190                 1195                 1200             


Pro Tyr  Gly Leu Arg Val Leu  Glu Thr Pro Ala Ala  Tyr Ser Ser 
    1205                 1210                 1215             


Lys Phe  Ser Ser Arg Asp Gly  Thr Ala Gly Phe Arg  Ala Val Glu 
    1220                 1225                 1230             


Val Thr  Pro Asp Asp Leu Gly  Ser His Arg Trp Arg  Lys His Ser 
    1235                 1240                 1245             


Glu Arg  Leu Ala Asp Pro Gly  Ala Ser Leu Ser Arg  Asp Glu Arg 
    1250                 1255                 1260             


Glu Glu  Ser Thr Arg Leu Met  Ala Phe Ala Glu Arg  Leu Lys Ala 
    1265                 1270                 1275             


Leu Asn  Gln Asp Leu Ile Ala  Arg Gln Glu Ala Ala  Arg Ser Ser 
    1280                 1285                 1290             


Asn Gln  Pro Phe Arg Pro Lys  Trp Arg Thr Leu Leu  Ala Pro Gln 
    1295                 1300                 1305             


Gln Leu  Gly Pro Ile Phe Val  Pro Ala Val Gly Lys  Pro Leu Gln 
    1310                 1315                 1320             


Ala Asp  Ile Asn Ala Ala Ile  Asn Ile Ala Leu Arg  Ala Ile Ala 
    1325                 1330                 1335             


Ser Pro  Asp Val Asp Asp Ile  His Leu Arg Ile Arg  Ala Ala Arg 
    1340                 1345                 1350             


Ser Gly  Asp Lys Phe Val Val  Arg Ala Glu Asn Thr  Arg Glu Arg 
    1355                 1360                 1365             


Ala Arg  Trp Gly Ser Ala Glu  Ala Glu Ile Gly Leu  Pro Thr Gly 
    1370                 1375                 1380             


Ala Gly  Ala Lys Glu Ile Glu  Glu Arg Arg Ser Leu  Leu Thr Glu 
    1385                 1390                 1395             


Ala Arg  Val Asn Phe Phe Phe  Asp Pro Ala Ser Val  Ala Ala Phe 
    1400                 1405                 1410             


Asp His  Gly Lys Val Arg Asp  Ala Lys Leu Ala Val  Thr Ser Gly 
    1415                 1420                 1425             


Arg Gly  Leu Trp Gly Thr Leu  Arg Arg Glu Glu Trp  Ala Ile Val 
    1430                 1435                 1440             


Gly Lys  Ile Asn Asn Asp Arg  Leu Ala Ala His Gly  Leu Gly Arg 
    1445                 1450                 1455             


Pro Phe  Ala Glu Arg Val Asp  Leu 
    1460                 1465     


<210> 580
<211> 1464
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 580
Met Ser Gln Arg Asp Pro Leu Pro Ser Pro Thr Pro Arg Ala Tyr Thr 
1               5                   10                  15      


Leu Arg Leu Ser Thr Pro Asp Ala Asp Asn Gly Ala Trp Arg Glu Arg 
            20                  25                  30          


Leu Trp Lys Thr His Glu Val Val Asn Ser Gly Ala Glu Ala Phe Gly 
        35                  40                  45              


Asp Trp Leu Leu Ser Leu Arg Gly Gly Leu Asp His Arg Leu Val Ala 
    50                  55                  60                  


Val Lys Val Arg Val Gly Arg Gly Ala Ser Lys Thr Glu Arg Glu Pro 
65                  70                  75                  80  


Thr Glu Asp Glu Arg Arg Glu Arg Arg Ile Val Leu Ala Leu Cys Trp 
                85                  90                  95      


Leu Ser Val Glu Ser Lys Lys Gly Ala Pro Gln Gly Arg Val Val Glu 
            100                 105                 110         


Asp Pro Val Asp Ala Leu Lys Arg Ile Leu Gly Gln Arg Gly Leu Ser 
        115                 120                 125             


Glu Ala Asp Ala Glu Gln Trp Val Phe Asp Cys Arg Asp Ser Leu Ser 
    130                 135                 140                 


Ala Thr Ile Arg Asp Asp Ala Thr Trp Val Asp Arg Ser Ala Ala Phe 
145                 150                 155                 160 


Asp Glu Thr Val Gln Arg Leu Gly Ser Ser Leu Thr Arg Glu His Ala 
                165                 170                 175     


Glu Gln Val Ile Ile Glu Phe Phe Gly Asp Ile His Asp Tyr Leu Ala 
            180                 185                 190         


Leu Pro Lys Asn Met Glu Glu Asp Gly Val Thr Ser Pro Arg Gly Gly 
        195                 200                 205             


Ser Gly Lys Glu Phe Arg Thr Gln Ala Arg Ser Trp Leu Ser Glu Asn 
    210                 215                 220                 


Trp Gly Ala Gly Gln Lys Gly Asp Lys Ala Gln Ile Val Asp Ala Leu 
225                 230                 235                 240 


Arg Lys Cys Ser Arg Cys Ile Ala Gln Glu Lys Pro Ser Thr Gly Ser 
                245                 250                 255     


Asp Leu Leu Arg Val Leu Val Arg Ser Leu Gly Gly Ser Pro Glu Glu 
            260                 265                 270         


Thr Leu Arg Phe Asp Glu Leu Arg Lys Leu Val Gly Trp Arg Thr Gly 
        275                 280                 285             


Arg Arg Ser Thr Gly Ala Phe Ala Leu Gln Arg Thr Val Asp Met Asp 
    290                 295                 300                 


Arg Leu Ser Glu Ser Asp Leu Glu Ser Leu Glu Ala Lys Leu Thr Val 
305                 310                 315                 320 


Glu Ile Asp Ala Lys Ser Pro Glu Ala Ser Arg Ser Val Pro Gln Trp 
                325                 330                 335     


Val Glu Ser Met Arg Thr Ala Val Glu Arg Glu Val Gly Met Pro Phe 
            340                 345                 350         


Arg Ser Thr Arg Asp Leu Ile Gly Glu Phe Gly Val Met Leu Asp His 
        355                 360                 365             


Ala Ala Arg Arg Val Ser Ala Thr His Ser Trp Ile Lys Arg Ala Glu 
    370                 375                 380                 


Ala Glu Arg Arg Lys Phe Glu Gly Asp Ala Ala Lys Leu Ala Gln Ile 
385                 390                 395                 400 


Pro Glu Glu Ala Arg Gln Trp Leu Asp Gln Phe Cys Glu Asp Arg Ser 
                405                 410                 415     


Gln Glu Leu Asn Ala Leu Glu Pro Tyr Arg Ile Arg Arg Arg Ala Val 
            420                 425                 430         


Glu Gly Trp Glu Ser Val Val Arg Thr Trp Ala Lys Ala Asp Cys Lys 
        435                 440                 445             


Ala Glu Gly Asp Arg Val Lys Ala Val Arg Ala Leu Gln Pro Glu Ile 
    450                 455                 460                 


Glu Lys Phe Gly Asp Ala Ala Leu Phe Glu Ala Leu Ala Ala Glu Asp 
465                 470                 475                 480 


Ala Leu Cys Val Trp Leu Leu Asp Gly Lys Ala Thr Pro Arg Pro Leu 
                485                 490                 495     


Leu Asp Tyr Ser Ala Ala Thr Asp Ala Gln Tyr Arg Lys Arg Arg Phe 
            500                 505                 510         


Lys Val Pro Ala Tyr Arg His Pro Asp Ala Leu Leu His Pro Val Phe 
        515                 520                 525             


Cys Asp Phe Gly Glu Ser Arg Trp Thr Ile Glu Phe Ser Ala His Arg 
    530                 535                 540                 


Ala Leu Gly Arg Arg Arg Lys Ala Gln Gln Leu Val Asp Asn Lys Thr 
545                 550                 555                 560 


Val Ala Leu Gln Lys Ala Gln Glu Arg Leu Arg Lys Ala Lys Ala Glu 
                565                 570                 575     


Ser Ser Arg Ser Arg Ala Glu Glu Lys Val Arg Ala Ala Glu His Ala 
            580                 585                 590         


Leu Glu Ala Ala Arg Lys Lys Leu Ala Phe Leu Gln Tyr Arg Arg Ala 
        595                 600                 605             


Leu Ala Val Cys Leu Trp Thr Gly Lys Gly Val Glu Ser Thr Ser Leu 
    610                 615                 620                 


Arg Trp His Ser Lys Arg Phe Ala Lys Asp Phe Ala Ile Gly Ser Ser 
625                 630                 635                 640 


Pro Glu Asp Gly Ala Ser Thr Gly Val Pro Val Ala Arg Ala Asp Arg 
                645                 650                 655     


Leu Gly Arg Ala Ser Ala Asn Val Pro Arg Gly Ala Ser Val Thr Ile 
            660                 665                 670         


Ser Gly Val Phe Glu Gln Lys Glu Trp Asn Gly Arg Leu Gln Ala Pro 
        675                 680                 685             


Arg Asp Ala Leu Asn Ala Ile Ala Lys Val Arg Asp Asp Glu Thr Leu 
    690                 695                 700                 


Pro Ala Ala Asp Arg Ser Arg Arg Val Gln Gln Met Leu Ser Arg Leu 
705                 710                 715                 720 


Pro Trp Phe Val Thr Phe Ser Ala Arg Leu Val Pro Gln Gly Pro Trp 
                725                 730                 735     


Leu Asp Tyr Ala Ser Glu His Ser Ala Leu Gly Leu Arg Val Asp Pro 
            740                 745                 750         


Lys Tyr Trp Pro His Ala Glu Glu Asn Arg Gln Arg Lys Gly Met Ala 
        755                 760                 765             


Arg Leu Ile Leu Ser Arg Leu Pro Ser Leu Arg Val Leu Ser Val Asp 
    770                 775                 780                 


Leu Gly His Arg Tyr Ala Ala Ala Cys Ala Val Trp Glu Thr Leu Ser 
785                 790                 795                 800 


Ala Gln Glu Met Gln Arg Ile Cys Arg Glu Met Gly Ser Ala Pro Pro 
                805                 810                 815     


Ser Pro Asp Asp Leu Tyr Leu His Leu Arg Arg Ala Asp Gly Asn Gly 
            820                 825                 830         


Lys Gln Arg Thr Thr Val Tyr Arg Arg Ile Gly Pro Asp Thr Leu Pro 
        835                 840                 845             


Asp Gly Gly Gln His Pro Ala Pro Trp Ala Arg Leu Asp Arg Gln Phe 
    850                 855                 860                 


Leu Ile Lys Leu Gln Gly Glu Asp Glu Ser Ala Arg Lys Ala Ser Asp 
865                 870                 875                 880 


Ser Glu Ile Ala Val Val Lys Lys Phe Glu Ala Asp Leu Gly Arg Pro 
                885                 890                 895     


Ala Met Gln Arg Arg Ser Leu Arg Val Asp Asp Leu Met Ser Ala Ala 
            900                 905                 910         


Val Arg Thr Ala Arg Leu Ala Leu Arg Arg His Gly Asp Arg Ala Arg 
        915                 920                 925             


Ile Ala Phe Asn Leu Ile Ala Asp Arg Arg Phe Arg Pro Gly Gly Ala 
    930                 935                 940                 


Glu Glu Pro Leu Thr Asp Glu Thr Arg Val Asp Leu Leu Ala Asp Thr 
945                 950                 955                 960 


Leu Ala Thr Trp His Gly Leu Phe Ser Gly Gly Gln Cys His Asp Glu 
                965                 970                 975     


Arg Ala Glu Glu Gln Trp Asn Glu His Ile Ala Pro Leu Leu Ala Ser 
            980                 985                 990         


Ser Gly Ala Ser Leu Ser Val Pro  Ser Asp Gly Asp Ala  Val Ala Ala 
        995                 1000                 1005             


Thr Pro  Ala Arg Arg Arg Arg  Lys Glu Val Arg Gly  Lys Leu Val 
    1010                 1015                 1020             


Pro Ala  Ala Met Glu Leu Ala  Arg Arg Asp Leu Ser  Gln Leu Ser 
    1025                 1030                 1035             


Val Leu  Trp Val Ala Arg Trp  His Gln Asp Asp Glu  Ser Trp Arg 
    1040                 1045                 1050             


Ala Arg  Leu Arg Trp Leu Arg  Asp Trp Ile Leu Pro  Arg Gly Ala 
    1055                 1060                 1065             


Lys Ala  Asp Ser Gly Ala Ile  Arg His Val Gly Gly  Leu Ser Val 
    1070                 1075                 1080             


Thr Arg  Leu Ala Thr Ile Arg  Ser Leu Trp Gln Leu  Gln Lys Ala 
    1085                 1090                 1095             


Tyr Arg  Thr Gln Pro Glu Pro  Glu Asp Pro Arg Lys  Asn Val Pro 
    1100                 1105                 1110             


Lys Lys  Gly Asp Thr Ser Leu  Asp Asp Phe Gly Arg  Thr Ile Leu 
    1115                 1120                 1125             


Asp Asp  Leu Glu His Leu Arg  Glu Asn Arg Val Lys  Gln Leu Ala 
    1130                 1135                 1140             


Ser Arg  Ile Cys Glu Ala Ala  Leu Gly Val Gly Val  Glu Gln Pro 
    1145                 1150                 1155             


Asn Gly  Gly Ala Lys Asp Pro  Lys Arg Pro Gln Glu  Arg Arg Phe 
    1160                 1165                 1170             


Ser Pro  Cys Gln Ala Val Val  Ile Glu Asn Leu Thr  Arg Tyr Arg 
    1175                 1180                 1185             


Pro Glu  Glu Thr Arg Thr Arg  Arg Glu Asn Arg Gln  Leu Leu Asn 
    1190                 1195                 1200             


Trp Ser  Ala Gly Lys Val Lys  Gln Tyr Leu Ser Glu  Ala Cys Glu 
    1205                 1210                 1215             


Leu His  Gly Leu His Leu Arg  Glu Val Ser Ala Ala  Tyr Thr Ser 
    1220                 1225                 1230             


Arg Gln  Asp Ser Arg Thr Gly  Ala Pro Gly Ile Arg  Cys Gln Asp 
    1235                 1240                 1245             


Ile Pro  Val Val Asp Phe Val  Arg Glu Asn Gly Pro  Cys Trp Gly 
    1250                 1255                 1260             


Arg Leu  Arg Ser Ala Gln Gln  Ser Ser Gly Gly Thr  Ala Glu Asp 
    1265                 1270                 1275             


Gln Leu  Leu Leu Ala Leu Tyr  Glu Arg Trp Ser Glu  Lys Glu Arg 
    1280                 1285                 1290             


Thr Trp  Arg Asp Gln Ser Gly  Asn Val Trp Ala Met  Asp Gly Glu 
    1295                 1300                 1305             


Gly Arg  Trp Val Ala Arg Asn  Gly Thr Gln Leu Pro  Gln Gly Ser 
    1310                 1315                 1320             


Gly Leu  Thr Pro His Pro Ile  Arg Val Pro Gln Arg  Gly Gly Asp 
    1325                 1330                 1335             


Ile Phe  Val Ser Ala Ala Pro  Arg Ser Pro Ala Ala  Asn Gly Ile 
    1340                 1345                 1350             


Gln Ala  Asp Leu Asn Ala Ala  Ala Asn Ile Gly Leu  Trp Ala Leu 
    1355                 1360                 1365             


Leu Asp  Pro Asp Trp Glu Gly  Arg Trp Trp Arg Leu  Pro Cys Ser 
    1370                 1375                 1380             


Ala Met  Asp Leu Lys Pro Val  Lys Gly Ser Val Asn  Gly Ser Ala 
    1385                 1390                 1395             


Val Ile  His Leu Asp Ala Pro  Leu Lys Ala Ala Ala  Thr Lys Gly 
    1400                 1405                 1410             


Ala Ala  Lys Lys Asp Val Val  Asn Leu Trp Arg Asp  Ile Ser Val 
    1415                 1420                 1425             


Arg Ser  Leu Thr Glu Gly Val  Trp Arg Gly Tyr Asp  Ala Tyr Trp 
    1430                 1435                 1440             


Asn Leu  Ala Arg Tyr Arg Val  Val Gln Thr Leu Arg  Pro Gln Val 
    1445                 1450                 1455             


Gly Ile  Gly Ser Asp Glu 
    1460                 


<210> 581
<211> 1247
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 581
Met Phe Lys Gly Asp Ala Phe Thr Gly Leu Tyr Glu Val Gln Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Val Pro Ile Gly Leu Thr Gln Ser Tyr Leu Glu 
            20                  25                  30          


Asn Asp Trp Val Ile Gln Lys Asp Lys Glu Val Glu Glu Asn Tyr Gly 
        35                  40                  45              


Lys Ile Lys Ala Tyr Phe Asp Leu Ile His Lys Glu Phe Val Arg Gln 
    50                  55                  60                  


Ser Leu Glu Asn Ala Trp Leu Cys Gln Leu Asp Asp Phe Tyr Glu Lys 
65                  70                  75                  80  


Tyr Ile Glu Leu His Asn Ser Leu Glu Thr Arg Lys Asp Lys Asn Leu 
                85                  90                  95      


Ala Lys Gln Phe Glu Lys Val Met Lys Ser Leu Lys Lys Glu Phe Val 
            100                 105                 110         


Ser Phe Phe Asp Ala Lys Trp Asn Glu Trp Lys Gln Lys Phe Ser Phe 
        115                 120                 125             


Leu Lys Lys Trp Trp Ile Asp Val Leu Asn Glu Lys Glu Val Leu Asp 
    130                 135                 140                 


Leu Met Ala Glu Phe Tyr Pro Asp Glu Lys Glu Leu Phe Asp Lys Phe 
145                 150                 155                 160 


Asp Lys Phe Phe Thr Tyr Phe Ser Asn Phe Lys Glu Ser Arg Lys Asn 
                165                 170                 175     


Phe Tyr Ala Asp Asp Gly Arg Ala Trp Ala Ile Ala Thr Arg Ala Ile 
            180                 185                 190         


Asp Glu Asn Leu Ile Thr Phe Ile Lys Asn Ile Glu Asp Phe Lys Lys 
        195                 200                 205             


Leu Asn Ser Ser Phe Arg Glu Phe Val Asn Asp Asn Phe Ser Glu Glu 
    210                 215                 220                 


Asp Lys Gln Ile Phe Glu Ile Asp Phe Tyr Asn Asn Cys Leu Leu Gln 
225                 230                 235                 240 


Pro Trp Ile Asp Lys Tyr Asn Lys Ile Val Trp Trp Tyr Ser Leu Glu 
                245                 250                 255     


Asn Trp Glu Lys Val Gln Trp Leu Asn Glu Lys Ile Asn Asn Phe Lys 
            260                 265                 270         


Gln Asn Gln Asn Lys Ser Asn Ser Lys Asp Leu Lys Phe Pro Arg Met 
        275                 280                 285             


Lys Leu Leu Tyr Lys Gln Ile Leu Gly Asp Lys Glu Lys Lys Val Tyr 
    290                 295                 300                 


Ile Asp Glu Ile Arg Asp Asp Lys Asn Leu Ile Asp Leu Ile Asp Asn 
305                 310                 315                 320 


Ser Lys Arg Arg Asn Gln Ile Lys Ile Asp Asn Ala Asn Asp Ile Ile 
                325                 330                 335     


Asn Asp Phe Ile Asn Asn Asn Ala Lys Phe Glu Leu Asp Lys Ile Tyr 
            340                 345                 350         


Leu Thr Arg Gln Ser Ile Asn Thr Ile Ser Ser Lys Tyr Phe Ser Ser 
        355                 360                 365             


Trp Asp Tyr Ile Arg Trp Tyr Phe Trp Thr Gly Glu Leu Gln Glu Phe 
    370                 375                 380                 


Val Ser Phe Tyr Asp Leu Lys Glu Thr Phe Trp Lys Ile Glu Tyr Glu 
385                 390                 395                 400 


Thr Leu Glu Asn Ile Phe Lys Asp Cys Tyr Val Lys Gly Ile Asn Thr 
                405                 410                 415     


Glu Ser Gln Asn Asn Ile Val Phe Glu Thr Gln Gly Ile Tyr Glu Asn 
            420                 425                 430         


Phe Leu Asn Ile Phe Lys Phe Glu Phe Asn Gln Asn Ile Ser Gln Ile 
        435                 440                 445             


Ser Leu Leu Glu Trp Glu Leu Asp Lys Ile Gln Asn Glu Asp Ile Lys 
    450                 455                 460                 


Lys Asn Glu Lys Gln Val Glu Val Ile Lys Asn Tyr Phe Asp Ser Val 
465                 470                 475                 480 


Met Ser Val Tyr Lys Met Thr Lys Tyr Phe Ser Leu Glu Lys Trp Lys 
                485                 490                 495     


Lys Arg Val Glu Leu Asp Thr Asp Asn Asn Phe Tyr Asn Asp Phe Asn 
            500                 505                 510         


Glu Tyr Leu Glu Gly Phe Glu Ile Trp Lys Asp Tyr Asn Leu Val Arg 
        515                 520                 525             


Asn Tyr Ile Thr Lys Lys Gln Val Asn Thr Asp Lys Ile Lys Leu Asn 
    530                 535                 540                 


Phe Asp Asn Ser Gln Phe Leu Thr Trp Trp Asp Lys Asp Lys Glu Asn 
545                 550                 555                 560 


Glu Arg Leu Gly Ile Ile Leu Arg Arg Glu Trp Lys Tyr Tyr Leu Trp 
                565                 570                 575     


Ile Leu Lys Lys Trp Asn Thr Leu Asn Phe Gly Asp Tyr Leu Gln Lys 
            580                 585                 590         


Glu Trp Glu Ile Phe Tyr Glu Lys Met Asn Tyr Lys Gln Leu Asn Asn 
        595                 600                 605             


Val Tyr Arg Gln Leu Pro Arg Leu Leu Phe Pro Leu Thr Lys Lys Leu 
    610                 615                 620                 


Asn Glu Leu Lys Trp Asp Glu Leu Lys Lys Tyr Leu Ser Lys Tyr Ile 
625                 630                 635                 640 


Gln Asn Phe Trp Tyr Asn Glu Glu Ile Ala Gln Ile Lys Ile Glu Phe 
                645                 650                 655     


Asp Ile Phe Gln Glu Ser Lys Glu Lys Trp Glu Lys Phe Asp Ile Asp 
            660                 665                 670         


Lys Leu Arg Lys Leu Ile Glu Tyr Tyr Lys Lys Trp Val Leu Ala Leu 
        675                 680                 685             


Tyr Ser Asp Leu Tyr Asp Leu Glu Phe Ile Lys Tyr Lys Asn Tyr Asp 
    690                 695                 700                 


Asp Leu Ser Ile Phe Tyr Ser Asp Val Glu Lys Lys Met Tyr Asn Leu 
705                 710                 715                 720 


Asn Phe Thr Lys Ile Asp Lys Ser Leu Ile Asp Gly Lys Val Lys Ser 
                725                 730                 735     


Trp Glu Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Ser 
            740                 745                 750         


Lys Lys Glu Trp Ser Thr Glu Asn Ile His Thr Lys Tyr Phe Lys Leu 
        755                 760                 765             


Leu Phe Asn Glu Lys Asn Leu Gln Asn Leu Val Val Lys Leu Ser Trp 
    770                 775                 780                 


Trp Ala Asp Ile Phe Phe Arg Asp Lys Thr Glu Asn Leu Lys Phe Lys 
785                 790                 795                 800 


Lys Asp Lys Asn Gly Gln Glu Ile Leu Asp His Arg Arg Phe Ser Gln 
                805                 810                 815     


Asp Lys Ile Met Phe His Ile Ser Ile Thr Leu Asn Ala Asn Cys Trp 
            820                 825                 830         


Asp Lys Tyr Trp Phe Asn Gln Tyr Val Asn Glu Tyr Met Asn Lys Glu 
        835                 840                 845             


Arg Asp Ile Lys Ile Ile Trp Ile Asp Arg Trp Glu Lys His Leu Ala 
    850                 855                 860                 


Tyr Tyr Cys Val Ile Asp Lys Ser Trp Lys Ile Phe Asn Asn Glu Ile 
865                 870                 875                 880 


Trp Thr Leu Asn Glu Leu Asn Trp Val Asn Tyr Leu Glu Lys Leu Glu 
                885                 890                 895     


Lys Ile Glu Ser Ser Arg Lys Asp Ser Arg Ile Ser Trp Trp Glu Ile 
            900                 905                 910         


Glu Asn Ile Lys Glu Leu Lys Asn Gly Tyr Ile Ser Gln Val Ile Asn 
        915                 920                 925             


Lys Leu Thr Glu Leu Ile Val Lys Tyr Asn Ala Ile Ile Val Phe Glu 
    930                 935                 940                 


Asp Leu Asn Ile Trp Phe Lys Arg Trp Arg Gln Lys Ile Glu Lys Gln 
945                 950                 955                 960 


Ile Tyr Gln Lys Leu Glu Leu Ala Leu Ala Lys Lys Leu Asn Tyr Leu 
                965                 970                 975     


Thr Gln Lys Asp Lys Lys Asp Asp Glu Ile Leu Trp Asn Leu Lys Ala 
            980                 985                 990         


Leu Gln Leu Val Pro Lys Val Asn  Asp Tyr Gln Asp Ile  Trp Asn Tyr 
        995                 1000                 1005             


Lys Gln  Ser Trp Ile Met Phe  Tyr Val Arg Ala Asn  Tyr Thr Ser 
    1010                 1015                 1020             


Val Thr  Cys Pro Asn Cys Trp  Leu Arg Lys Asn Leu  Tyr Ile Ser 
    1025                 1030                 1035             


Asn Ser  Ala Thr Lys Glu Asn  Gln Lys Lys Ser Leu  Asn Ser Ile 
    1040                 1045                 1050             


Ala Ile  Lys Tyr Asn Asp Trp  Lys Phe Ser Phe Ser  Tyr Glu Ile 
    1055                 1060                 1065             


Asp Asp  Lys Ser Trp Lys Gln  Lys Gln Ser Leu Asn  Lys Lys Lys 
    1070                 1075                 1080             


Phe Ile  Val Tyr Ser Asp Ile  Glu Arg Phe Val Tyr  Ser Pro Leu 
    1085                 1090                 1095             


Glu Lys  Leu Thr Lys Val Ile  Asp Val Asn Lys Lys  Leu Leu Glu 
    1100                 1105                 1110             


Leu Phe  Arg Asp Phe Asn Leu  Ser Leu Asp Ile Asn  Lys Gln Ile 
    1115                 1120                 1125             


Gln Glu  Lys Asp Leu Asp Ser  Val Phe Phe Lys Ser  Leu Thr His 
    1130                 1135                 1140             


Leu Phe  Asn Leu Ile Leu Gln  Leu Arg Asn Ser Asp  Ser Lys Asp 
    1145                 1150                 1155             


Asn Lys  Asp Tyr Ile Ser Cys  Pro Ser Cys Tyr Tyr  His Ser Asn 
    1160                 1165                 1170             


Asn Trp  Leu Gln Trp Phe Glu  Phe Asn Trp Asp Ala  Asn Trp Ala 
    1175                 1180                 1185             


Tyr Asn  Ile Ala Arg Lys Gly  Ile Ile Leu Leu Asp  Arg Ile Arg 
    1190                 1195                 1200             


Lys Asn  Gln Glu Lys Pro Asp  Leu Tyr Val Ser Asp  Ile Asp Trp 
    1205                 1210                 1215             


Asp Asn  Phe Val Gln Ser Asn  Gln Phe Pro Asn Thr  Ile Ile Pro 
    1220                 1225                 1230             


Ile Gln  Asn Ile Glu Lys Gln  Val Pro Leu Asn Ile  Lys Ile 
    1235                 1240                 1245         


<210> 582
<211> 1250
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 582
Met Leu Ser Phe Asn Trp Val Leu Phe Phe Phe Phe Ser Lys Met Ser 
1               5                   10                  15      


Arg Ser Ile Phe Ser Pro Phe Thr Asn Leu Tyr Pro Ile Gln Lys Thr 
            20                  25                  30          


Leu Arg Arg Glu Leu Lys Pro Leu Asn Glu Asn Phe Gln His Asp Pro 
        35                  40                  45              


Ala Leu Ser Ala Leu Arg Asn Ser Glu Ile Pro Gln Arg Asp Glu Gln 
    50                  55                  60                  


Arg Glu Lys Asp Tyr Gln Ala Ile Lys Pro Leu Leu Asp Glu Phe His 
65                  70                  75                  80  


Asn Gln Phe Ile Thr Glu Ser Leu His Ser Leu Glu Pro Gln Asp Arg 
                85                  90                  95      


Ser Asp Phe Ile Leu Phe Tyr Gln Thr Tyr Gln Lys Lys Lys Lys Asn 
            100                 105                 110         


Lys Ala Glu Ile Ser Glu Lys Glu Leu Lys Ser Leu Asp Glu Glu Phe 
        115                 120                 125             


Glu Ser Arg Thr Lys Ala Leu Arg Asn Ala Ile Gly Thr Ser Phe Ser 
    130                 135                 140                 


Val Thr Ala Glu Leu Arg Lys Ser Asn Pro Asp Tyr Val Ser Glu Lys 
145                 150                 155                 160 


Gly Lys Pro Phe Leu Thr Gln Lys Ser Tyr Lys Ile Leu Thr Glu Ala 
                165                 170                 175     


Gly Val Leu Trp Leu Leu Glu Lys Lys Tyr Thr Ser Asp Pro Glu Lys 
            180                 185                 190         


Leu Ala Leu Ile Arg Arg Phe Gly Asn Phe Phe Thr Tyr Phe Thr Gly 
        195                 200                 205             


Phe Asn Gln Asn Arg Glu Asn Tyr Tyr Ala Thr Asp Glu Lys Ser Thr 
    210                 215                 220                 


Ala Val Ala Tyr Arg Ala Ile Asn Glu Asn Leu Leu Thr Phe Ala Asn 
225                 230                 235                 240 


Asn Cys Glu Leu Phe Glu Lys Leu Ser Val Leu Ser Leu Ser Glu Leu 
                245                 250                 255     


Glu Lys Lys Thr Phe Asn Pro Asp Ser Tyr Ser Glu Tyr Leu Thr Gln 
            260                 265                 270         


Ser Gly Ile Val Phe Tyr Asn Glu Met Leu Ala Asn Ile Arg Ser Lys 
        275                 280                 285             


Ala Asn Leu Tyr Thr Gln Glu His Lys Ala Lys Leu Pro Gln Pro Lys 
    290                 295                 300                 


Leu Leu Tyr Lys Gln Ile Trp Ser Pro Arg Gly Asp Thr Ile Pro Phe 
305                 310                 315                 320 


Asp Leu Ile Ala Ser Glu Ala Glu Phe Gln Glu Thr Leu His Thr Met 
                325                 330                 335     


Ile Arg Glu Thr Asp Gln Arg Ile Pro Glu Phe Asn Lys Leu Leu Glu 
            340                 345                 350         


Gln Ile Phe Glu Glu Lys Val Asp Leu Ser Gln Ile Phe Phe Ser Lys 
        355                 360                 365             


Thr Ser Leu Asn Ile Ile Ser Asn Arg Tyr Phe Ser Ser Trp His Thr 
    370                 375                 380                 


Leu Leu Glu Lys Gly Val Glu Leu Lys Leu Phe Lys Phe Lys Lys Asn 
385                 390                 395                 400 


Asp Glu Glu Ser Phe Lys Leu Pro Ala Tyr Leu Ser Leu Ala Glu Leu 
                405                 410                 415     


Lys Glu Leu Leu Glu Ser Ala Pro Phe Gln Met Ala Glu Lys Ala Asp 
            420                 425                 430         


Ala Asp Glu Glu Lys His His Gln Ala Ser Leu Phe Lys Leu Gln Arg 
        435                 440                 445             


Glu Asn Leu His Leu Glu Lys Ser His Ser Asn Trp Glu Leu Leu Leu 
    450                 455                 460                 


Lys Ser Met Lys Ser Asp Phe Glu Ser Phe Trp Thr Trp Glu Gly Glu 
465                 470                 475                 480 


Phe Trp Ser Tyr Thr Leu Ala Lys Lys Ala Leu Gln Ser Leu Ser Ala 
                485                 490                 495     


Leu Glu Ser Thr Asn Gln Glu His Lys Asn Leu Ile Lys Met Leu Leu 
            500                 505                 510         


Asp Asn Ala Leu Tyr Ala Tyr Arg Met Leu Lys Trp Phe Lys Val Asp 
        515                 520                 525             


Thr Ser Lys Leu Gly Phe Val Pro Glu Gly Glu Phe Tyr Pro Ser Leu 
    530                 535                 540                 


Asp Gln Leu Leu Gln Asp Tyr Pro Leu Pro Lys Trp Tyr Asp Met Ile 
545                 550                 555                 560 


Arg Asn Tyr Leu Thr Arg Lys Thr Tyr Ser Gln Ala Lys Leu Lys Leu 
                565                 570                 575     


Asn Phe Asp Cys Ser Thr Leu Leu Asn Gly Arg Asp Lys Asn Lys Glu 
            580                 585                 590         


Ile Gln Asn Leu Ser Val Ile Leu Arg Lys Asp Gly Lys Phe Tyr Leu 
        595                 600                 605             


Ala Ile Met Lys Lys Asp Gln Asn Lys Phe Phe Glu Asn Ser Ala Leu 
    610                 615                 620                 


Tyr Glu Gly Asn Leu Gly Thr Met Glu Lys Met Asp Tyr Lys Leu Leu 
625                 630                 635                 640 


Pro Trp Ala Asn Lys Met Leu Pro Lys Cys Leu Met Pro Gly Ser Asp 
                645                 650                 655     


Lys Lys Lys Tyr Gly Ala Ser Asp Gln Val Leu Glu Leu Tyr Ala Lys 
            660                 665                 670         


Gly Ser Phe Lys Lys Ser Glu Lys Ser Phe Asn Leu Ala Asp Leu His 
        675                 680                 685             


Thr Leu Ile Asp Phe Tyr Lys Leu Ala Leu Pro Lys Tyr Glu Asp Trp 
    690                 695                 700                 


Lys Val Phe Asn Phe Gln Phe Gln Ala Thr Glu Asn Tyr Gln Asp Ile 
705                 710                 715                 720 


Ser Gln Phe Tyr Arg Glu Val Glu Gln Gln Gly Tyr Leu Leu Asn Trp 
                725                 730                 735     


Arg Lys Val Asn Glu Lys Leu Ile Lys Gln Gly Ile Lys Asp Trp Ser 
            740                 745                 750         


Leu Phe Leu Phe Gln Ile Ser Ser Lys Asp Phe Glu Gly Lys Ser Lys 
        755                 760                 765             


Thr Pro Asp Leu Gln Thr Leu Tyr Trp Gln Gln Leu Phe Glu Phe Ser 
    770                 775                 780                 


Thr Asn Val Lys Leu Asn Gly Glu Ala Glu Ile Phe Phe Arg Pro Trp 
785                 790                 795                 800 


Ser Met Lys Lys Glu Lys Lys Lys Leu Lys Val Asp Asn Tyr Asp Val 
                805                 810                 815     


Phe Lys His Lys Arg Tyr Thr Glu Asp Lys Ile Leu Phe His Val Pro 
            820                 825                 830         


Ile Thr Leu Trp Phe Gly Asn Asn Glu Val Ser Pro Ser Ala Pro Ser 
        835                 840                 845             


Lys Phe Asn Gln Lys Leu Asn Gln Glu Leu Ile Ile Pro His Phe Asp 
    850                 855                 860                 


Asp Leu His Val Ile Gly Val Asp Arg Trp Glu Lys His Leu Ala Phe 
865                 870                 875                 880 


Tyr Ser Val Val Ser Val Lys Thr Gly Lys Ile Val Lys Gln Gly Thr 
                885                 890                 895     


Leu Asn Leu Leu Asn Gly Thr Asp Tyr Glu Ala Lys Leu Ser Gln Lys 
            900                 905                 910         


Ala Glu Asn Arg Leu Tyr Ala Arg Gln Asn Arg Asp Thr Ile Glu Lys 
        915                 920                 925             


Ile Ala Asp Leu Lys Asn Gly Tyr Ile Ser Gln Val Val Asn Lys Leu 
    930                 935                 940                 


Val Glu Leu Val Leu Glu Tyr Asn Ala Val Ile Val Phe Glu Asp Leu 
945                 950                 955                 960 


Asn Ala Gly Phe Lys Arg Gly Arg Gln Lys Ile Glu Gln Ser Val Tyr 
                965                 970                 975     


Gln Lys Leu Glu Leu Ala Leu Ala Lys Lys Leu Asn Phe Ile Val Lys 
            980                 985                 990         


Lys Glu Lys Ala Val Gly Glu Pro  Trp Ser Val Thr Ser  Ala Tyr Gln 
        995                 1000                 1005             


Leu Ala  Pro Gln Ile Asn Thr  Phe Trp Asp Ile Lys  Trp Lys Gln 
    1010                 1015                 1020             


Arg Gly  Ile Met Leu Tyr Thr  Arg Ala Asn Tyr Thr  Ser Val Thr 
    1025                 1030                 1035             


Asp Pro  Leu Thr Gly Trp Arg  Lys Gln Tyr Tyr Phe  Lys Lys Gly 
    1040                 1045                 1050             


Ser Ser  Glu Glu Met Lys Ala  Gln Phe Phe Lys Ser  Phe Lys Asn 
    1055                 1060                 1065             


Leu Thr  Arg Asp Ala Gly Gln  Glu Ala Tyr Ile Phe  Asp Asp Gly 
    1070                 1075                 1080             


Thr Trp  Leu Leu Tyr Ser Asn  Val Glu Arg Arg Arg  Gly Lys Arg 
    1085                 1090                 1095             


Gly Asp  His Arg Glu Arg Thr  Gln Ile Lys Tyr Asp  Pro Ser Leu 
    1100                 1105                 1110             


Glu Leu  Asp Thr Leu Phe Ser  Lys Tyr Gln Ile Glu  Lys Ser Asp 
    1115                 1120                 1125             


Ser Leu  Phe Asp Gln Leu Lys  Asn Arg Glu Leu Pro  Gln Thr Phe 
    1130                 1135                 1140             


Trp Thr  Ser Phe Phe Arg Ile  Ile Asp Leu Ile Met  Gln Ile Arg 
    1145                 1150                 1155             


Asn Thr  Asp Asp Glu Gly Arg  Asp Ile Ile Leu Ser  Pro Ile Gly 
    1160                 1165                 1170             


Asn Pro  Gln Glu Arg Phe Asp  Ser Arg Lys Arg Tyr  Asn Gln Leu 
    1175                 1180                 1185             


Pro Arg  Asp Glu Lys Gly Gly  Ile Ile Glu Glu Ser  Ala Phe Glu 
    1190                 1195                 1200             


Tyr Pro  Thr Ser Trp Asp Ala  Asn Gly Ala Tyr Asn  Ile Ala Arg 
    1205                 1210                 1215             


Lys Gly  Val Met Met Leu Glu  Arg Ile Lys Glu Asn  Pro Glu Lys 
    1220                 1225                 1230             


Pro Asp  Leu Leu Ile Arg Asp  Ala Glu Trp Asp Lys  Lys Ile Thr 
    1235                 1240                 1245             


Arg Lys  
    1250 


<210> 583
<211> 669
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 583
Met Leu Asp Lys Phe Ala Ser Leu Tyr Pro Val Thr Lys Thr Leu Arg 
1               5                   10                  15      


Phe Arg Leu Leu Pro Gln Gly Arg Thr Glu Glu Asn Met Gln Val Ala 
            20                  25                  30          


Lys Val Leu Glu Asn Asp Leu Glu Arg Ser Glu Ala Ala Ala Val Val 
        35                  40                  45              


Lys Gly Leu Ile Lys Lys Tyr His Leu Gln Phe Ile Ser Asp Thr Leu 
    50                  55                  60                  


Ser Gly Ser Thr Leu Ser Trp Gln Ala Leu Thr Glu Thr Leu Asp Lys 
65                  70                  75                  80  


Phe Lys Ala Asp His Thr Ala Thr Ala Glu Leu Asp Ser Ala Leu Ala 
                85                  90                  95      


Ala Tyr Arg Cys Lys Leu Ala Glu Leu Phe Thr Lys Ser Pro Lys Tyr 
            100                 105                 110         


Lys Val Met Ala Thr Pro Val Ser Ile Ile Lys Glu Ile Leu Lys Thr 
        115                 120                 125             


Glu Thr Asp Pro Glu Asn Ile Ala Ala Leu Asn Lys Leu Asn Gly Tyr 
    130                 135                 140                 


Thr Tyr Ile Ile Phe Asp Tyr Val Ser Thr Arg Met Leu Thr Tyr Ser 
145                 150                 155                 160 


Ala Asp Ala Lys Ala Thr Ser Leu Ala Tyr Arg Leu Val Asp Glu Asn 
                165                 170                 175     


Tyr Leu Arg Phe Tyr Gln Asp Ile Ser Ala Ala Ala Glu Ile Ser Ala 
            180                 185                 190         


Val Leu Glu Glu Ala Gly Phe Asp Asn Ala Glu Val Glu Ala Phe Ile 
        195                 200                 205             


Arg Thr Asp Tyr Asn Thr Cys Leu Thr Ser Glu Gly Ile Ala Ser Phe 
    210                 215                 220                 


Asn Ala Ala Ala Gly Ser Ile Asn Gln Phe Val Asn Val Leu Leu Gln 
225                 230                 235                 240 


Gln Asn Pro Val Leu Gln Ser Glu Pro Ala Leu Arg Arg His Leu Gln 
                245                 250                 255     


Pro Leu Tyr Lys Met Leu Leu Asp Glu Ala Glu Ser Lys Ile Ile Lys 
            260                 265                 270         


Phe Glu Asp Tyr Gly Gln Leu Arg Asp Ala Val Glu Asn Phe Arg Arg 
        275                 280                 285             


Asn Phe Gln Asp Leu Pro Gln Ser Leu Ile Asp Ile Phe Ala Gly Arg 
    290                 295                 300                 


Tyr Asp Tyr Ser Lys Ile Tyr Val Gly Tyr Lys Tyr Leu Asn Glu Ala 
305                 310                 315                 320 


Ser Ser Gln Ile Ala Gly Gly Tyr Asn Trp Lys Leu Leu Glu Asn Ala 
                325                 330                 335     


Leu Glu Asp Phe Tyr Ser Lys Pro Tyr Leu Val Asn Gly Lys Leu Pro 
            340                 345                 350         


Val Lys Tyr Lys Thr Val Val Asn Lys Lys Met Asn Gln Leu Ala Tyr 
        355                 360                 365             


Ser Phe Thr Glu Leu Gln Glu Ala Leu Asp Ala Gly Asp Ser Gly Ser 
    370                 375                 380                 


Ser Ile Thr Asp Leu Phe Gly Lys Tyr Ala Glu Leu His Ala Ala Tyr 
385                 390                 395                 400 


Ala Ala Ala Asp Gly Asn Val Phe Tyr Lys Glu Tyr Asp Arg Lys Ser 
                405                 410                 415     


Ile Ala Ser Leu Lys Asn Tyr Leu Asp Ala Val Asn Ala Ile Ala Arg 
            420                 425                 430         


Phe Ile Lys Ile Phe Ala Ala Pro Glu Val Tyr Val Lys Asp Glu Gly 
        435                 440                 445             


Phe Tyr Gly Ile Val Asp Gly Ala Ala Asp Lys Leu Arg Asp Phe Asp 
    450                 455                 460                 


Leu Leu Tyr Asn Met Val Arg Asn Tyr Ile Thr Lys Lys Pro Tyr Lys 
465                 470                 475                 480 


Lys Ser Lys Val Ala Leu Thr Phe Asn Ser Ser Ser Phe Gly Arg Gly 
                485                 490                 495     


Trp Asp Glu Asn Lys Ile Tyr Asp Glu Leu Thr Thr Ile Phe Thr Tyr 
            500                 505                 510         


Asn Gly Lys Tyr Tyr Leu Gly Val Ile Asn Lys Asn Asp Lys Pro Asp 
        515                 520                 525             


Leu Ala Ala Ala Val Ser Lys Asp Glu Gly Gly Tyr Lys Arg Met Val 
    530                 535                 540                 


Tyr Lys Thr Phe Asp Ile Val Lys Gln Leu Pro Arg Leu Ser Phe Thr 
545                 550                 555                 560 


Lys Ala Val Lys Ala His Phe Ala Glu Ser Asp Glu Asp Phe Ile Phe 
                565                 570                 575     


Asp Gly Pro Lys Phe Ala Lys Pro Leu Arg Val Pro Lys Glu Ile Tyr 
            580                 585                 590         


Leu Gln Ser Phe Thr Asp Asn Gly Asp Lys Leu Ala Asp Ser Ala Lys 
        595                 600                 605             


Lys Tyr Thr Lys Ala Tyr Leu Asp Met Ser Gly Asp Tyr Lys Gly Tyr 
    610                 615                 620                 


Tyr Glu Ala Ile Ile Lys Arg Ile Asp Tyr Thr Lys Glu Phe Leu Ser 
625                 630                 635                 640 


Ala Tyr Lys Ser Thr Ser Ile Tyr Asp Leu Ala Phe Leu Lys Pro Ala 
                645                 650                 655     


Gly Lys Ala Ala Gly Ser Leu Cys Trp Thr Arg His Ile 
            660                 665                 


<210> 584
<211> 1367
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 584
Met Asn Arg Ile Tyr Gln Gly Arg Val Thr Lys Val Glu Ile Leu Asn 
1               5                   10                  15      


Gly Lys Asn Ala Asp Gly Gln Pro Gln Glu Leu Pro Asn Trp Gln Thr 
            20                  25                  30          


Ala Leu Trp Gln His His Glu Leu Phe Gln Asp Ala Val Asn Tyr Tyr 
        35                  40                  45              


Leu Phe Cys Leu Ala Ala Leu Ala Ser Ser Ala Ser Ser Pro Met Gly 
    50                  55                  60                  


Lys Leu Arg Asn Gln Leu Gly Ser Val Trp Glu Pro Phe Gly Arg Thr 
65                  70                  75                  80  


Gly Arg Arg Phe Lys Gly Leu Arg Asp Ser Val Gly Pro Tyr Leu Leu 
                85                  90                  95      


Pro Asp Arg Pro Thr Pro Ser Ile Glu Glu Ala Phe Ala Ala Ala Leu 
            100                 105                 110         


Ala Gly Asn Asn Ser Gln Pro Glu Leu Leu Gln Leu Ala Val Asp Ala 
        115                 120                 125             


Leu Val Glu Asp Leu Gly Gly Asp Ala Ala Ile Gln Gln Glu Gly Arg 
    130                 135                 140                 


Gly Tyr Leu Pro Arg Leu Cys Ser Pro Ala Tyr Asn Gly Gln Phe Pro 
145                 150                 155                 160 


Arg Gly Ala Asn Ser Leu Gln Lys Glu Ala Ala Lys Ile Arg Leu Pro 
                165                 170                 175     


Thr Leu Leu His Asn Val Ala Thr Ser Arg Asn Leu Asp Ala Leu Ala 
            180                 185                 190         


Ala Glu Leu Glu Phe Gly Phe Phe Ala Asn Pro Val Pro Asn Ala Gly 
        195                 200                 205             


Pro Ile Ala Gly Gln Glu Ala Arg Asn Lys Leu Leu Glu Ala Leu Ala 
    210                 215                 220                 


Trp Leu Lys Ala Lys Asp Thr Arg Leu Thr His Ser Ala Asn Glu Leu 
225                 230                 235                 240 


Glu Lys Arg Ile Gly Val Leu Pro Asp Ser Val Ser Phe Pro Thr Tyr 
                245                 250                 255     


Ser Gly Gly Ser Ile Asn Lys Glu Ala Leu Lys His Arg Phe Phe Ala 
            260                 265                 270         


Tyr Leu Leu Phe Gln His Val Glu Arg Ser Leu Val Thr Phe Glu Ile 
        275                 280                 285             


Leu Arg Asp Ser Tyr Pro Thr Pro Lys Pro Ser Ala Arg Lys Ser Ser 
    290                 295                 300                 


Lys Ala Thr Pro Asp Thr Met Ala Gln Leu Thr Gln Phe Gly Asp Asp 
305                 310                 315                 320 


Pro Val Lys Leu Ala Arg Gly Thr Arg Gly Tyr Val Phe Arg Ala Phe 
                325                 330                 335     


Thr Ser Leu Pro Cys Trp Gly Ala Lys Ala Pro Ser Asp Ile Leu Trp 
            340                 345                 350         


Ser Glu Phe Asp Ile Ala Ala Phe Lys Glu Ala Leu Lys Thr Ala Asn 
        355                 360                 365             


Gln Phe Arg Leu Lys Thr Lys Glu Arg Leu Asp Lys Ala Asp Glu Leu 
    370                 375                 380                 


Ala Gly Glu Leu Ala Trp Met Asn Gly Glu Lys Ser Lys Phe Lys Pro 
385                 390                 395                 400 


Ser Glu His Ser Glu Gln Glu Pro Pro Ala Val Leu Lys Gly Asp Pro 
                405                 410                 415     


Arg Phe Glu Val Leu Lys Gln Leu Phe Glu Val Glu Leu Ala Glu Glu 
            420                 425                 430         


His Tyr Leu Ala Glu Gly Glu Ser Val Ile Tyr Gly Leu His Pro Arg 
        435                 440                 445             


Thr Leu Arg Cys Tyr Arg Glu Leu Val Glu Arg Trp Asn Lys Thr Val 
    450                 455                 460                 


Gln Pro Gly Glu Val Phe Thr Glu Ala Thr Ser Lys Lys Leu Val Ala 
465                 470                 475                 480 


Ser Thr Asp Lys Phe Gln Ala Glu Asn Lys Glu Arg Ile Gly Ser Val 
                485                 490                 495     


Thr Leu Phe Lys Lys Leu Leu Glu Arg Asp Tyr Trp Cys Leu Trp Gln 
            500                 505                 510         


Thr Pro Asp Val Gln Thr Val Ala Ala Arg Gln Lys Ala Gly Phe Ser 
        515                 520                 525             


Ser Asn Ile Ile Glu Asp Tyr Gln Arg Tyr Leu Glu Leu Gln Thr Asp 
    530                 535                 540                 


Ile Ala Arg Leu Lys Glu Pro Ile Arg Phe Thr Pro Ala Asp Ala Glu 
545                 550                 555                 560 


Gln Ser Arg Arg Leu Phe Met Phe Ser Asp Leu Ala Gly Lys Ser Lys 
                565                 570                 575     


His Lys His Leu Pro Asn Ala Thr Pro Tyr Gly Phe Ala Val Asp Val 
            580                 585                 590         


Ala Leu Ala Ala Ser Glu Gly Gly Val Trp Lys Glu Thr Arg Val Arg 
        595                 600                 605             


Leu His Tyr Ser Ala Pro Arg Leu Arg Arg Asp Gly Leu Arg Lys Gly 
    610                 615                 620                 


Val Gly Glu Asp Leu Lys Arg Thr Ala Trp Leu Gln Pro Met Val Ala 
625                 630                 635                 640 


Ala Leu Asn Leu Ser Glu Pro Ala Pro Gln Asp Phe Ser Lys Cys Ala 
                645                 650                 655     


Val Ser Leu Met Pro Asp Lys Ser Trp Lys Gly Leu Arg His Leu Leu 
            660                 665                 670         


Asn Phe Pro Val Thr Leu Asp Pro Thr Val Val Gln Lys Ala Ile Gly 
        675                 680                 685             


Ser Gln Ala Arg Trp Ala Asn Gln Phe Val Ala Phe Gly Lys Gly Ala 
    690                 695                 700                 


Thr Glu Gln Lys Phe Phe Leu Arg Trp Pro Glu Glu Val Ser Ala Ser 
705                 710                 715                 720 


Gln Lys Lys Ala Gly Pro Trp Trp Asp Ala Leu Arg Ala Phe Ser Cys 
                725                 730                 735     


Leu Ser Val Asp Leu Gly Gln Arg Asp Ala Gly Ala Phe Ala Leu Leu 
            740                 745                 750         


Asp Val Arg Ala Asn Ala Asp Trp Gly Lys Lys Pro Ser Arg Phe Ile 
        755                 760                 765             


Gly Glu Ala Asp Gly Arg Asn Trp Arg Ala Ala Leu Ala Ala Ala Gly 
    770                 775                 780                 


Leu Leu Arg Leu Pro Gly Glu Asp Ala Leu Val Trp Arg Asp Gly Lys 
785                 790                 795                 800 


Trp Gln Glu Glu Leu Tyr Gly Glu Lys Gly Arg Leu Ala Thr Lys Glu 
                805                 810                 815     


Glu Trp Leu Glu Thr Asn Ala Ile Phe Ser Ala Leu Glu Gln Asn Ser 
            820                 825                 830         


Glu Glu Trp Ile Gly Ala Asp Pro Lys Arg Arg Ser Phe Pro Glu Leu 
        835                 840                 845             


Asn Ser Lys Leu Leu Val Val Ala Arg Arg Gly Gln Ser Trp Leu Ala 
    850                 855                 860                 


Arg Leu His Arg Trp Leu Trp Met Leu Gly Asp Glu Asn Lys Arg Glu 
865                 870                 875                 880 


Arg Ala Leu Arg Glu Leu Leu Glu Gln Glu Arg Gln Glu Ala Trp Arg 
                885                 890                 895     


Lys Arg Ala Glu Gly Lys Asp Leu Leu Ala Leu Lys Gln Ser Leu Thr 
            900                 905                 910         


Ala Glu Ile Gln Arg Leu Asn Gly Leu Leu Pro Glu Gln Leu Val Phe 
        915                 920                 925             


Leu Ala Asn Arg Cys Leu Pro Leu Arg Asn Arg Lys Trp Ala Trp Asn 
    930                 935                 940                 


Gln His Pro Asp Lys Ala Phe Ala Glu Lys Gly Cys His Leu Leu Glu 
945                 950                 955                 960 


Met Val Glu Ala Pro Ser His Leu Pro Leu Leu Ala Gly Gln Arg Gly 
                965                 970                 975     


Ile Ser Phe Glu Arg Ile Gly Gln Leu Glu Glu Leu Arg Arg Arg Phe 
            980                 985                 990         


Gln Ser Leu Asn Arg Val Leu Gln  Arg Glu Leu Gly Ala  Pro Pro Lys 
        995                 1000                 1005             


Ser Gly  Arg Glu Leu Arg Asp  Asp Leu Val Pro Asp  Cys Cys Pro 
    1010                 1015                 1020             


Asp Ile  Leu Ala Lys Leu Asp  Arg Val Lys Glu Gln  Arg Val Asn 
    1025                 1030                 1035             


Gln Thr  Ala His Leu Ile Val  Ala Gln Val Leu Gly  Val Gln Leu 
    1040                 1045                 1050             


Arg Lys  His Gln Thr Pro Glu  Ser Glu Arg Thr Glu  Arg Asp Leu 
    1055                 1060                 1065             


His Gly  Glu Tyr Glu Ile Met  Pro Gly Arg Lys Pro  Val Asp Phe 
    1070                 1075                 1080             


Ile Val  Leu Glu Asp Leu Ser  Lys Tyr Leu Ser Ser  Gln Ala Arg 
    1085                 1090                 1095             


Gly Arg  Gly Glu Asn Val Arg  Leu Met Lys Trp Cys  His Arg Gln 
    1100                 1105                 1110             


Val Thr  Ala Lys Val Lys Glu  Leu Cys Glu Pro Phe  Gly Leu Pro 
    1115                 1120                 1125             


Val Leu  Glu Thr Pro Ala Ala  Tyr Ser Ser Lys Phe  Cys Ser Arg 
    1130                 1135                 1140             


Thr Gly  Val Ala Gly Phe Arg  Gly Val Glu Val Thr  Leu Lys Asp 
    1145                 1150                 1155             


Arg Gln  Ser Phe Pro Trp Ser  Lys Arg Leu Glu Glu  Asp Ser Ala 
    1160                 1165                 1170             


Glu Val  Ala Glu Leu Phe Gly  Trp Leu Glu Thr Ala  Ser Ala Gly 
    1175                 1180                 1185             


His Lys  Thr Lys Gln Pro Arg  Cys Leu Leu Ala Pro  Met Ser Leu 
    1190                 1195                 1200             


Gly Pro  Leu Phe Ile Pro Val  Thr Ser Gln Ala Pro  Ile Met Gln 
    1205                 1210                 1215             


Ala Asp  Ile Asn Ala Ala Ile  Asn Leu Gly Leu Arg  Ala Met Ala 
    1220                 1225                 1230             


Ala Pro  Ser Val His Glu Ile  His Val Arg Ile Arg  Ser Glu Ala 
    1235                 1240                 1245             


Lys Asp  Gly Gln Phe Arg Val  Arg Ala Gln Ser Lys  Arg Glu Lys 
    1250                 1255                 1260             


Ala Arg  Trp Gly Asn Glu Pro  Pro Pro Ile Lys Met  Leu Val Glu 
    1265                 1270                 1275             


Thr Gln  Arg Val Ala Leu Ala  Arg Glu Gly Gly His  Pro Asn Phe 
    1280                 1285                 1290             


Phe Val  Asp Pro Leu Lys Ala  Ala Thr Phe Asp Arg  Ala Glu Val 
    1295                 1300                 1305             


Glu Gly  Leu Gly Leu Pro Val  Ala Ser Gly Arg Gly  Leu Trp Lys 
    1310                 1315                 1320             


Ser Val  Arg Asp Ala Glu Trp  Lys Arg Cys Arg Glu  Ile Asn Leu 
    1325                 1330                 1335             


Glu Arg  Met Arg Arg Trp Gly  Phe Ile Met Glu Ala  Pro Arg Thr 
    1340                 1345                 1350             


Leu Gln  Val Ser Arg Lys Glu  Asp Glu Asp Asp Leu  Thr Phe 
    1355                 1360                 1365         


<210> 585
<211> 1202
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 585
Met Ala Val Arg Ser Val Lys Leu Lys Leu Leu Val Pro Arg Asp Gly 
1               5                   10                  15      


Ser Ala Glu Ser Val Arg Lys Arg Lys Ala Leu Trp Ala Thr His Gln 
            20                  25                  30          


Phe Val Asn Asp Ala Ala Ala Ala Tyr Ala Glu Leu Leu Leu Glu Met 
        35                  40                  45              


Arg Gln Glu Asp Val Cys Arg Gly Thr Asp Asp His Gly Lys Asp Val 
    50                  55                  60                  


Ile Glu Pro Ala Ala His Trp Gln Ala Lys Leu Arg Ala Arg Leu Ala 
65                  70                  75                  80  


Ala Lys Gln Leu Pro Pro Val Ala Val Ala Glu Ala Leu Pro Leu Leu 
                85                  90                  95      


Lys Ala Phe Tyr Gly Ser Arg Leu Ile Lys Ser Phe Val Ala Asn Asp 
            100                 105                 110         


Lys Gly Val Ala Gly Thr Gly Asn Ala Thr Asp Leu Asn Thr Trp Leu 
        115                 120                 125             


Ser Gly Leu Val Asp Pro Ala Ser Val Ala Gly Glu Lys Thr Glu Leu 
    130                 135                 140                 


Arg Lys Gln Leu Leu Ala Glu Leu Pro Leu Cys Glu Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Phe Glu Gly Ala Ala Arg Lys Met Leu Ala Lys Ser Asp Ala Arg 
                165                 170                 175     


Glu Ala Leu Leu Glu Gly Pro Gly Thr Gly Val Gly Trp Pro Ala Ala 
            180                 185                 190         


Tyr Asn Ala Asn Pro Thr Asp Ser Val Trp Leu Asp Met Leu His Lys 
        195                 200                 205             


Ala Ala Ala Lys Ala Arg Leu Glu Leu Ala Asp Thr Thr Val Ser Glu 
    210                 215                 220                 


Leu Lys Lys Leu Gly Val Phe Pro Leu Leu Gln Ala Ala Ser Ser Asn 
225                 230                 235                 240 


Arg Val Phe Gly Ser Gly Val Leu Asn Pro Phe Glu Arg Met Ala Ala 
                245                 250                 255     


Ala Gln Ala Ala Ala Ala Leu Leu Pro Trp Glu Thr Lys Arg His Glu 
            260                 265                 270         


Met Arg Lys Arg Arg Asp Lys Phe Ala Asp Gln Leu Asn Gln Trp Asp 
        275                 280                 285             


Thr Glu Phe Gly Ala Ser His Ala Thr Ala Leu Ala Ala Ile Arg Ala 
    290                 295                 300                 


Phe Glu Ala Glu Glu Ser Glu Arg Ala Arg Arg Glu Ser Leu Gly Asn 
305                 310                 315                 320 


Glu Gly Thr Gly Tyr Arg Ile Gly Gly Arg Glu Leu Arg Asp Ala Trp 
                325                 330                 335     


Thr Leu Leu Arg Asp Trp Leu Lys Gly His Ser Thr Ala Thr Ala Ala 
            340                 345                 350         


Ala Arg Glu Asp Lys Val Arg Glu Leu Gln Ala Lys Gln Gly Arg Ser 
        355                 360                 365             


Phe Gly Ser His Arg Leu Leu Ser Trp Leu Ala Lys Pro Ala Gln Gln 
    370                 375                 380                 


Trp Leu Ala Asp His Ser Ala Gly Asp Val Val Thr Arg Ile Ala Val 
385                 390                 395                 400 


Arg Asn Ala Arg Gln Arg Lys Leu Asp Thr Ala Arg Thr Leu Pro Ile 
                405                 410                 415     


Trp Thr Gly Ala Asp Ala Val Lys His Pro Arg Phe Ala Asn Phe Asp 
            420                 425                 430         


Pro Pro Asn Asn Thr Asn Gln Pro Gly Phe Asp Leu Arg Ala Gly Thr 
        435                 440                 445             


Gln Lys Gly Arg Leu Thr Leu Arg Leu Ser Leu Leu Thr Glu Arg Ala 
    450                 455                 460                 


Asp Gly Leu Leu Leu Ala Gln Asp His Asp Phe Gln Leu Val Pro Ser 
465                 470                 475                 480 


Arg Gln Met Ala Glu Ile Val Leu His Lys Asp Gly Lys Glu Arg Ala 
                485                 490                 495     


Leu Ser Trp Gln Ser Gln Asp Gly Ile Gly Arg Gln Val Gly Asp Val 
            500                 505                 510         


Gly Gly Ser Ala Leu Leu Phe Ser Arg Asp His Ala Glu Cys Leu Leu 
        515                 520                 525             


Glu Arg Lys Gln Ile Thr Arg Leu Glu Arg Gly Ala Trp Pro Ala Ala 
    530                 535                 540                 


Leu Pro Val Trp Phe Lys Leu Ser Leu Asp Ile Gly Ala Glu His Lys 
545                 550                 555                 560 


Ala Leu Leu Lys Gln Arg Phe Lys Trp Gly Val Trp Leu Asn Ser Ala 
                565                 570                 575     


Leu Val Thr Arg Asn Ala Lys Asp Ala Lys Gly Val Pro Pro Pro Val 
            580                 585                 590         


Gly Thr Arg Val Leu Ala Val Asp Leu Gly Leu Arg Ser Ala Ala Thr 
        595                 600                 605             


Val Ser Val Trp Gln Val Val Asp Ala Ala Thr Pro Val Val Ala Gly 
    610                 615                 620                 


Lys Trp Arg Val Pro Leu Ser Asp Thr Leu Ser Ala Val His Glu Arg 
625                 630                 635                 640 


Ser Ala Met Leu Ala Leu Pro Gly Glu His Val Asp Ala Gly Val Leu 
                645                 650                 655     


Ala Ala Arg Arg Ala Ala Asn Glu Lys Leu Ala Gly Leu Leu Ala Ala 
            660                 665                 670         


Thr Ser His Leu Ser Thr Val Phe Lys Leu Gly Arg Ala Glu Gln Gly 
        675                 680                 685             


Asp Arg Arg Arg Glu Leu Leu Glu Arg Leu Gly Glu Gly Asp Asp Arg 
    690                 695                 700                 


Arg Ala Arg Ala Ala Val Ala Thr Thr Ala Ala Glu Arg Asp Gly Leu 
705                 710                 715                 720 


Arg Ala Val Leu Gly Ala Thr Gln Asp Ala Trp Ala Gly Ala Val Ala 
                725                 730                 735     


Ala Val Trp Arg Arg Leu Glu Thr Asp Leu Ala Gly Ala Ile Ala Ala 
            740                 745                 750         


Tyr Arg Lys Gln Gln Arg Glu Asp Val Gln Leu Arg Arg Glu Ala Arg 
        755                 760                 765             


His Gly Pro Gly Ala Ser Gln Leu Pro Lys Gln Ala Ala Ala Glu Arg 
    770                 775                 780                 


Leu Leu Gly Gly Lys Ser Ala Trp Gln Ile Glu Tyr Lys Glu Arg Val 
785                 790                 795                 800 


Arg Lys Leu Leu Thr Arg Trp Ile Met Arg Gln Arg Pro Gly Asp Thr 
                805                 810                 815     


Ala Val Arg Arg Leu Ala Arg Lys Asp Leu Gly Lys Tyr Cys Gly Gly 
            820                 825                 830         


Leu Leu Asp His Leu Thr Ala Leu Lys Glu Asp Arg Ala Lys Thr Thr 
        835                 840                 845             


Ala Asp Leu Ile Val Gln Ala Ala Arg Gly Arg Val Arg Ala His Lys 
    850                 855                 860                 


Asp Ala His Gly Arg Gln Gln Asp Arg Glu Leu Trp Leu Ala Lys Tyr 
865                 870                 875                 880 


Ala Pro Cys Asp Leu Ile Val Met Glu Asp Leu Gly Arg Tyr Arg Phe 
                885                 890                 895     


Ala Thr Asp Arg Pro Pro Ser Glu Asn Arg Gln Leu Met Gln Trp Thr 
            900                 905                 910         


His Arg Glu Val Phe Arg Leu Val Gln Met Gln Ala Glu Val Glu Gly 
        915                 920                 925             


Ile Gln Val Leu Glu Thr Gly Ala Glu Phe Ser Ser Lys Phe Asp Ala 
    930                 935                 940                 


Arg Thr Trp Ala Pro Gly Val Arg Cys Glu Pro Ile Thr Lys Leu Trp 
945                 950                 955                 960 


Val Glu Arg Tyr Arg Asn Gly Glu Met Pro Trp Leu Ala Asp Lys Ala 
                965                 970                 975     


Asp Glu Trp Arg Arg Glu Gly Ile Glu Leu Ala Gln Leu Val Pro Gly 
            980                 985                 990         


Gln Leu Leu Pro Thr Gly Ser Gly  Glu Gln Phe Val Ala  Val Ser Ala 
        995                 1000                 1005             


Thr Gly  Gly Leu Arg Val Arg  His Ala Asp Leu Asn  Ala Ala Gln 
    1010                 1015                 1020             


Cys Ile  Ala Leu Arg Ala Leu  Thr Gly His Gly Thr  Ala Phe Arg 
    1025                 1030                 1035             


Leu Thr  Ala Arg Arg Leu Gly  Asp Val Phe Val Ser  Ala Lys Gly 
    1040                 1045                 1050             


Leu Gly  Lys Arg Pro Gln Gly  Ala Leu Trp Arg Glu  Phe Gly Ser 
    1055                 1060                 1065             


Ala Leu  Pro Pro Ala Val Val  Val Leu Arg Pro Ala  Gly Glu Val 
    1070                 1075                 1080             


Arg Tyr  Ala Leu Arg Pro Phe  Ala Ser Ala Arg Asp  Ala Ala Ala 
    1085                 1090                 1095             


Ala Leu  Gly Leu Gln Leu Gly  Ala Leu Arg Asn Val  Asp Ala Thr 
    1100                 1105                 1110             


Asp Ala  Glu Ser Asp Ala Glu  Asp Gly Asp Leu Ala  Glu Leu Leu 
    1115                 1120                 1125             


Ala Gly  Ala Asp Pro Asp Arg  Ala Thr Phe Phe Arg  Asp Pro Ser 
    1130                 1135                 1140             


Gly Asp  Val His Gly Gly Ala  Trp Val Gln Ala Lys  Val Phe Trp 
    1145                 1150                 1155             


Ala Glu  Val Arg Arg His Val  Arg Leu Gly Leu Gln  Ala Gln Gly 
    1160                 1165                 1170             


Leu Leu  Pro Ala Ala Ala Arg  Ser Ser Glu Pro Arg  Gln Met Gln 
    1175                 1180                 1185             


Leu Pro  Leu Ala Gly Ala Leu  Pro Gly Asp Asp Ile  Pro Leu 
    1190                 1195                 1200         


<210> 586
<211> 1352
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 586
Met Ser Thr Gln Lys Asn Pro Phe Asn Gln Phe Thr Asn Leu Tyr Glu 
1               5                   10                  15      


Leu Gln Lys Thr Leu Arg Phe Glu Leu Arg Pro Val Pro Glu Thr Lys 
            20                  25                  30          


Lys Leu Leu Glu Lys Gly Glu Gly Lys Asn Leu Ile Gln Met Asp Leu 
        35                  40                  45              


Glu Ile Asp Arg Leu Tyr Glu Lys Glu Met Lys Pro Met Phe Asn Ile 
    50                  55                  60                  


Leu His Glu Lys Phe Ile Asn Glu Ser Leu Gly Leu Val Lys Leu Asp 
65                  70                  75                  80  


Cys Lys Lys Leu Lys Lys Leu Glu Asn Leu Leu Ala Glu Ala Asp Lys 
                85                  90                  95      


Leu Arg Lys Gln Ile Lys Glu Gly Arg Lys Asn Lys Asn Asn Ile Ser 
            100                 105                 110         


Glu Val Glu Lys Arg Leu Lys Ile Ile Ile Gly Asp Asn Ser Gln Gly 
        115                 120                 125             


Lys Asn Lys Asn Gly Glu Ile Ala Val Leu Gln Asp Glu Leu Arg Val 
    130                 135                 140                 


Leu Ile Val Lys Ala Phe Asn Leu Thr Ala Asp Lys Trp Lys Lys Glu 
145                 150                 155                 160 


Leu Asn Asn Lys Glu Thr Leu Leu Pro Glu Lys Lys Gly Lys Arg Lys 
                165                 170                 175     


Ile Lys Ile Lys Lys Ser Gly Pro Lys Ile Leu Gln Glu Glu Asn Val 
            180                 185                 190         


Leu Ala Ile Leu Ala Tyr Phe Asn Pro Asp Lys Ala Asp Ile Ile Lys 
        195                 200                 205             


Lys Phe Ala Gly Phe Phe Thr Tyr Phe Ser Gly Phe Asn Gln Asn Arg 
    210                 215                 220                 


Ala Asn Tyr Tyr Thr Val Lys Ala Leu Ala Thr Gly Val Ala Asn Arg 
225                 230                 235                 240 


Ala Ile Asn Arg Asn Phe Leu Ile Phe Leu Ala Asn Arg Lys Asp Phe 
                245                 250                 255     


Ala Arg Phe Lys Glu Arg Leu Pro Arg Leu Ala Glu Phe Asp Asn Tyr 
            260                 265                 270         


Phe Glu Leu Glu Asn Tyr Glu Lys Tyr Leu Ser Gln Thr Gly Ile Glu 
        275                 280                 285             


Glu Tyr Asn Asp Gln Ile Gly Lys Ile Lys Gln Ile Val Asn Leu Glu 
    290                 295                 300                 


His Asn Gln Gln Gln Lys Asp Asn Lys Phe Gln Leu Lys Gly Leu Ala 
305                 310                 315                 320 


Thr Leu Glu Lys Gln Ile Gly Cys Arg Thr Lys Lys Gln Arg Glu Glu 
                325                 330                 335     


Gly Gly Asp Lys Ser Ala Pro Lys Phe Leu Glu Lys Val Gly Leu Gly 
            340                 345                 350         


Phe Gln Val Ser Gln Asp Asp Asp Gly Glu Tyr Leu Ile Trp Glu Cys 
        355                 360                 365             


Leu Asn Tyr Ile Asn Lys Glu Leu Ala Gly Lys Leu Lys Ser Ile Lys 
    370                 375                 380                 


Asp Asn Tyr Gln Lys Phe Phe Ala Asp Trp Arg Thr Gly Ala Tyr Asp 
385                 390                 395                 400 


Leu Glu Lys Ile Trp Phe Arg Lys Glu Ala Leu Asn Thr Ile Ser Gly 
                405                 410                 415     


Arg Trp Phe Gly Gly Asn Asn Trp Phe Ile Ile Gly Lys Ala Leu Ala 
            420                 425                 430         


Leu Thr Gly Val Gly Lys Phe Asp Lys Arg Glu Asn Thr Tyr Lys Ile 
        435                 440                 445             


Pro Glu Phe Val Ser Leu Ala Glu Ile Lys Thr Ala Phe Glu Met Leu 
    450                 455                 460                 


Glu Asn Gly Val Asn Tyr Asp Phe Lys Lys Ser Lys Lys Lys Lys Glu 
465                 470                 475                 480 


Gly Asp Asp Thr Asp Val Val Lys Tyr Ser Ala Asp Asn Leu Phe Lys 
                485                 490                 495     


Glu Glu Tyr Lys Lys Lys Gly Leu Ile Lys Asn Ser Leu Phe Glu Thr 
            500                 505                 510         


Met Leu Ala Val Trp Gln Ser Glu Ile Lys Arg Lys Phe Glu Gln Ile 
        515                 520                 525             


Phe Asp Gly Tyr Lys Leu Glu Lys Asp Asp Val Phe Gly Arg Lys Lys 
    530                 535                 540                 


Gly Glu Trp Val Glu Pro Phe Ile Glu Asn Phe Gln Lys Val Ser Gln 
545                 550                 555                 560 


Glu Lys Phe Asp Arg Gly Val Lys Asp Glu Asn Gly Arg Ser Ile His 
                565                 570                 575     


Thr Glu Val Val Lys Asn Leu Ile Glu Glu Gly Tyr Leu Arg Leu Phe 
            580                 585                 590         


Gln Leu Thr Lys Tyr His Asn Leu Asp Lys Lys Gly Glu Arg Asp Pro 
        595                 600                 605             


Arg Pro Phe Asp Gly Asn Phe Tyr Ala Thr Leu Asp Glu Phe Trp Lys 
    610                 615                 620                 


Asp Asn Ile Val Val Val Tyr His Lys Ala Leu Gln Ser Thr Leu Thr 
625                 630                 635                 640 


Lys Lys Pro Tyr Ser Glu Asp Lys Ile Lys Leu Asn Phe Glu Asn Gly 
                645                 650                 655     


Ser Leu Leu Gly Gly Phe Ser Asp Gly Gln Glu Arg Ser Lys Ala Gly 
            660                 665                 670         


Val Val Leu Lys Asn Lys Asn Lys Phe Tyr Leu Gly Ile Leu Ile Asp 
        675                 680                 685             


Arg Gly Phe Phe Arg Thr Asp Lys Ala Asn Pro Val Tyr Asp Asn Ala 
    690                 695                 700                 


Gln Asn Asn Glu Trp Glu Arg Leu Ile Leu Thr Asn Leu Lys Phe Gln 
705                 710                 715                 720 


Thr Leu Ala Gly Lys Gly Phe Leu Gly Lys His Gly Val Ser Tyr Gly 
                725                 730                 735     


Glu Met Gly Lys Asp Asn Pro Met Met Ala Val Glu Tyr Leu Gln Lys 
            740                 745                 750         


Phe Ile Lys Leu Lys Tyr Leu Asp Lys Tyr Pro Ala Leu Asn Glu Val 
        755                 760                 765             


Ala His Lys Lys Tyr Thr Ile Lys Lys Glu Phe Asp Ala Asp Val Lys 
    770                 775                 780                 


Asn Ala Leu Lys Asp Cys Phe Thr Met Asn Phe Lys Pro Val Asp Phe 
785                 790                 795                 800 


Gly Met Ile Arg Gln Gly Leu Thr Glu Ser Leu Phe Tyr Leu Phe Glu 
                805                 810                 815     


Ile Val Asn Lys Asp Ile Ser Ser Gln Ala Lys Asn Gly Lys Asn Val 
            820                 825                 830         


His Thr Leu Tyr Trp Glu Ala Leu Phe Gly Asp Gln Asn Leu Lys Lys 
        835                 840                 845             


Pro Ile Leu Ala Leu Asn Gly Gly Ala Glu Ile Phe Tyr Arg Glu Ser 
    850                 855                 860                 


Gln Arg Glu Lys Leu Glu Lys Lys Leu Asp Lys Ser Gly Lys Glu Val 
865                 870                 875                 880 


Leu Asp His Lys Arg Tyr Gly Gln Asp Lys Tyr Phe Leu His Ala Ser 
                885                 890                 895     


Ile Thr Ile Asn Tyr Gly Gln Pro Lys Asn Ile Lys Phe Lys Glu Val 
            900                 905                 910         


Ile Asn Glu Lys Ile Ser Gln Asn Ala Asp Arg Val Asn Ile Ile Gly 
        915                 920                 925             


Ile Asp Arg Gly Glu Lys His Leu Leu Tyr Tyr Ser Val Val Ser Pro 
    930                 935                 940                 


Glu Gly Val Leu Leu Glu Gln Gly Ser Phe Asn Gln Ile Glu Thr Lys 
945                 950                 955                 960 


Asn Lys Val Asp Ile Lys Ala Val Lys Ala Glu Tyr Gly Glu Arg Gly 
                965                 970                 975     


Glu Leu Lys Lys Val Glu Leu Val Pro Thr Gly Lys Lys Val Lys Tyr 
            980                 985                 990         


Val Asp Tyr Gln Ile Leu Leu Asp  Tyr Tyr Glu Lys Lys  Arg Asn Leu 
        995                 1000                 1005             


Ala Arg  Arg Asp Trp Gln Thr  Ile Gly Lys Ile Lys  Asp Leu Lys 
    1010                 1015                 1020             


Asp Gly  Tyr Leu Ser Gln Thr  Val His Arg Ile Tyr  Gln Leu Ile 
    1025                 1030                 1035             


Leu Lys  Tyr Asn Ala Val Val  Ala Met Glu Asp Leu  Asn Val Glu 
    1040                 1045                 1050             


Phe Lys  Ala Lys Arg Ala Ala  Lys Val Glu Lys Ser  Val Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Glu Met Ala Leu Ala  Lys Lys Leu Asn His  Leu Ile Leu 
    1070                 1075                 1080             


Lys Asp  Arg Arg Ala Asp Glu  Ile Gly Gly Ala Leu  Arg Ala Tyr 
    1085                 1090                 1095             


Gln Leu  Thr Pro Ala Ile Pro  Ala Asn Asp Val Gly  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ala  Lys Gln Trp Gly Ile  Met Phe Tyr Val Arg  Ala Asn Tyr 
    1115                 1120                 1125             


Thr Ser  Thr Thr Asp Pro Leu  Thr Gly Trp Arg Lys  His Lys Tyr 
    1130                 1135                 1140             


Ile Ser  Asn Ser Glu Lys Ile  Asp Asn Ile Gln Lys  Phe Phe Ser 
    1145                 1150                 1155             


Pro Gly  Asp Gly Ile Gln Ile  Asp Tyr Asp Thr Glu  Lys Gln Cys 
    1160                 1165                 1170             


Phe Lys  Phe Ser Tyr Asp His  Glu Leu Glu Gly Gly  Ala Lys Lys 
    1175                 1180                 1185             


His Trp  Glu Leu Phe Ala Cys  Asp Gly Leu Glu Arg  Phe Tyr Trp 
    1190                 1195                 1200             


Asp Asn  Arg Glu Arg Gln Ile  Lys Lys Tyr Asn Leu  Tyr Glu Glu 
    1205                 1210                 1215             


Phe Glu  Lys Leu Leu Gly Gly  Leu Arg Lys Glu Glu  Asn Ile Asn 
    1220                 1225                 1230             


Ile Gln  Ile Asp Gly Val Ser  Glu Phe Arg Trp Lys  Asp Leu Val 
    1235                 1240                 1245             


Phe Phe  Trp Asn Leu Leu Asn  Gln Ile Arg Asn Thr  Asp Arg Ser 
    1250                 1255                 1260             


Ala Gln  Gly Asp Glu Asn Asp  Phe Leu Gln Ser Pro  Val Trp Ser 
    1265                 1270                 1275             


Glu Lys  Tyr Asn Cys Phe Tyr  Asp Ser Arg Lys Ala  Pro Asn Asn 
    1280                 1285                 1290             


Met Pro  Asn Asn Gly Asp Ala  Asn Gly Ala Phe Asn  Ile Ala Arg 
    1295                 1300                 1305             


Lys Gly  Gln Leu Ile Leu Glu  Arg Ile Lys Lys Cys  Ser Asp Ile 
    1310                 1315                 1320             


Pro Lys  Phe Gly Asn Asp Asn  Asn Gly Lys Asn Pro  Glu Asn Asn 
    1325                 1330                 1335             


Tyr Phe  Ile Ser Asp Ala Asp  Trp Asp Lys Phe Ala  Gln Lys 
    1340                 1345                 1350         


<210> 587
<211> 1129
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 587
Met Ala Val Lys Ser Ile Lys Val Lys Leu Arg Leu Asp Asp Met Pro 
1               5                   10                  15      


Glu Ile Arg Ala Gly Leu Trp Lys Leu His Lys Glu Val Asn Ala Gly 
            20                  25                  30          


Val Arg Tyr Tyr Thr Glu Trp Leu Ser Leu Leu Arg Gln Glu Asn Leu 
        35                  40                  45              


Tyr Arg Arg Ser Pro Asn Gly Asp Gly Glu Gln Glu Cys Asp Lys Thr 
    50                  55                  60                  


Ala Glu Glu Cys Lys Ala Glu Leu Leu Glu Arg Leu Arg Ala Arg Gln 
65                  70                  75                  80  


Val Glu Asn Gly His Arg Gly Pro Ala Gly Ser Asp Asp Glu Leu Leu 
                85                  90                  95      


Gln Leu Ala Arg Gln Leu Tyr Glu Leu Leu Val Pro Gln Ala Ile Gly 
            100                 105                 110         


Ala Lys Gly Asp Ala Gln Gln Ile Ala Arg Lys Phe Leu Ser Pro Leu 
        115                 120                 125             


Ala Asp Lys Asp Ala Val Gly Gly Leu Gly Ile Ala Lys Ala Gly Asn 
    130                 135                 140                 


Lys Pro Arg Trp Val Arg Met Arg Glu Ala Gly Glu Pro Gly Trp Glu 
145                 150                 155                 160 


Glu Glu Lys Glu Lys Ala Glu Thr Arg Lys Ser Ala Asp Arg Thr Ala 
                165                 170                 175     


Asp Val Leu Arg Ala Leu Ala Asp Phe Gly Leu Lys Pro Leu Met Arg 
            180                 185                 190         


Val Tyr Thr Asp Ser Glu Met Ser Ser Val Glu Trp Lys Pro Leu Arg 
        195                 200                 205             


Lys Gly Gln Ala Val Arg Thr Trp Asp Arg Asp Met Phe Gln Gln Ala 
    210                 215                 220                 


Ile Glu Arg Met Met Ser Trp Glu Ser Trp Asn Gln Arg Val Gly Gln 
225                 230                 235                 240 


Glu Tyr Ala Lys Leu Val Glu Gln Lys Asn Arg Phe Glu Gln Lys Asn 
                245                 250                 255     


Phe Val Gly Gln Glu His Leu Val His Leu Val Asn Gln Leu Gln Gln 
            260                 265                 270         


Asp Met Lys Glu Ala Ser Pro Gly Leu Glu Ser Lys Glu Gln Thr Ala 
        275                 280                 285             


His Tyr Val Thr Gly Arg Ala Leu Arg Gly Ser Asp Lys Val Phe Glu 
    290                 295                 300                 


Lys Trp Gly Lys Leu Ala Pro Asp Ala Pro Phe Asp Leu Tyr Asp Ala 
305                 310                 315                 320 


Glu Ile Lys Asn Val Gln Arg Arg Asn Thr Arg Arg Phe Gly Ser His 
                325                 330                 335     


Asp Leu Phe Ala Lys Leu Ala Glu Pro Glu Tyr Gln Ala Leu Trp Arg 
            340                 345                 350         


Glu Asp Ala Ser Phe Leu Thr Arg Tyr Ala Val Tyr Asn Ser Ile Leu 
        355                 360                 365             


Arg Lys Leu Asn His Ala Lys Met Phe Ala Thr Phe Thr Leu Pro Asp 
    370                 375                 380                 


Ala Thr Ala His Pro Ile Trp Thr Arg Phe Asp Lys Leu Gly Gly Asn 
385                 390                 395                 400 


Leu His Gln Tyr Thr Phe Leu Phe Asn Glu Phe Gly Glu Arg Arg His 
                405                 410                 415     


Ala Ile Arg Phe His Lys Leu Leu Lys Val Glu Asn Gly Val Ala Arg 
            420                 425                 430         


Glu Val Asp Asp Val Thr Val Pro Ile Ser Met Ser Glu Gln Leu Asp 
        435                 440                 445             


Asn Leu Leu Pro Arg Asp Pro Asn Glu Pro Ile Ala Leu Tyr Phe Arg 
    450                 455                 460                 


Asp Tyr Gly Ala Glu Gln His Phe Thr Gly Glu Phe Gly Gly Ala Lys 
465                 470                 475                 480 


Ile Gln Cys Arg Arg Asp Gln Leu Ala His Met His Arg Arg Arg Gly 
                485                 490                 495     


Ala Arg Asp Val Tyr Leu Asn Val Ser Val Arg Val Gln Ser Gln Ser 
            500                 505                 510         


Glu Ala Arg Gly Glu Arg Arg Pro Pro Tyr Ala Ala Val Phe Arg Leu 
        515                 520                 525             


Val Gly Asp Asn His Arg Ala Phe Val His Phe Asp Lys Leu Ser Asp 
    530                 535                 540                 


Tyr Leu Ala Glu His Pro Asp Asp Gly Lys Leu Gly Ser Glu Gly Leu 
545                 550                 555                 560 


Leu Ser Gly Leu Arg Val Met Ser Val Asp Leu Gly Leu Arg Thr Ser 
                565                 570                 575     


Ala Ser Ile Ser Val Phe Arg Val Ala Arg Lys Asp Glu Leu Lys Pro 
            580                 585                 590         


Asn Ser Lys Gly Arg Val Pro Phe Phe Phe Pro Ile Lys Gly Asn Asp 
        595                 600                 605             


Asn Leu Val Ala Val His Glu Arg Ser Gln Leu Leu Lys Leu Pro Gly 
    610                 615                 620                 


Glu Thr Glu Ser Lys Asp Leu Arg Ala Ile Arg Glu Glu Arg Gln Arg 
625                 630                 635                 640 


Thr Leu Arg Gln Leu Arg Thr Gln Leu Ala Tyr Leu Arg Leu Leu Val 
                645                 650                 655     


Arg Cys Gly Ser Glu Asp Val Gly Arg Arg Glu Arg Ser Trp Ala Lys 
            660                 665                 670         


Leu Ile Glu Gln Pro Val Asp Ala Ala Asn His Met Thr Pro Asp Trp 
        675                 680                 685             


Arg Glu Ala Phe Glu Asn Glu Leu Gln Lys Leu Lys Ser Leu His Gly 
    690                 695                 700                 


Ile Cys Ser Asp Lys Glu Trp Met Asp Ala Val Tyr Glu Ser Val Arg 
705                 710                 715                 720 


Arg Val Trp Arg His Met Gly Lys Gln Val Arg Asp Trp Arg Lys Asp 
                725                 730                 735     


Val Arg Ser Gly Glu Arg Pro Lys Ile Arg Gly Tyr Ala Lys Asp Val 
            740                 745                 750         


Val Gly Gly Asn Ser Ile Glu Gln Ile Glu Tyr Leu Glu Arg Gln Tyr 
        755                 760                 765             


Lys Phe Leu Lys Ser Trp Ser Phe Phe Gly Lys Val Ser Gly Gln Val 
    770                 775                 780                 


Ile Arg Ala Glu Lys Gly Ser Arg Phe Ala Ile Thr Leu Arg Glu His 
785                 790                 795                 800 


Ile Asp His Ala Lys Glu Asp Arg Leu Lys Lys Leu Ala Asp Arg Ile 
                805                 810                 815     


Ile Met Glu Ala Leu Gly Tyr Val Tyr Ala Leu Asp Glu Arg Gly Lys 
            820                 825                 830         


Gly Lys Trp Val Ala Lys Tyr Pro Pro Cys Gln Leu Ile Leu Leu Glu 
        835                 840                 845             


Glu Leu Ser Glu Tyr Gln Phe Asn Asn Asp Arg Pro Pro Ser Glu Asn 
    850                 855                 860                 


Asn Gln Leu Met Gln Trp Ser His Arg Gly Val Phe Gln Glu Leu Ile 
865                 870                 875                 880 


Asn Gln Ala Gln Val His Asp Leu Leu Val Gly Thr Met Tyr Ala Ala 
                885                 890                 895     


Phe Ser Ser Arg Phe Asp Ala Arg Thr Gly Ala Pro Gly Ile Arg Cys 
            900                 905                 910         


Arg Arg Val Pro Ala Arg Cys Thr Gln Glu His Asn Pro Glu Pro Phe 
        915                 920                 925             


Pro Trp Trp Leu Asn Lys Phe Val Val Glu His Thr Leu Asp Ala Cys 
    930                 935                 940                 


Pro Leu Arg Ala Asp Asp Leu Ile Pro Thr Gly Glu Gly Glu Ile Phe 
945                 950                 955                 960 


Val Ser Pro Phe Ser Ala Glu Glu Gly Asp Phe His Gln Ile His Ala 
                965                 970                 975     


Asp Leu Asn Ala Ala Gln Asn Leu Gln Gln Arg Leu Trp Ser Asp Phe 
            980                 985                 990         


Asp Ile Ser Gln Ile Arg Leu Arg  Cys Asp Trp Gly Glu  Val Asp Gly 
        995                 1000                 1005             


Glu Leu  Val Leu Ile Pro Arg  Leu Thr Gly Lys Arg  Thr Ala Asp 
    1010                 1015                 1020             


Ser Tyr  Ser Asn Lys Val Phe  Tyr Thr Asn Thr Gly  Val Thr Tyr 
    1025                 1030                 1035             


Tyr Glu  Arg Glu Arg Gly Lys  Lys Arg Arg Lys Val  Phe Ala Gln 
    1040                 1045                 1050             


Glu Lys  Leu Ser Glu Glu Glu  Ala Glu Leu Leu Val  Glu Ala Asp 
    1055                 1060                 1065             


Glu Ala  Arg Glu Lys Ser Val  Val Leu Met Arg Asp  Pro Ser Gly 
    1070                 1075                 1080             


Ile Ile  Asn Arg Gly Asn Trp  Thr Arg Gln Lys Glu  Phe Trp Ser 
    1085                 1090                 1095             


Met Val  Asn Gln Arg Ile Glu  Gly Tyr Leu Val Lys  Gln Ile Arg 
    1100                 1105                 1110             


Ser Arg  Val Pro Leu Gln Asp  Ser Ala Cys Glu Asn  Thr Gly Asp 
    1115                 1120                 1125             


Ile 
    


<210> 588
<211> 1352
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 588
Met Ser Thr Gln Lys Asn Pro Phe Asn Gln Phe Thr Asn Leu Tyr Glu 
1               5                   10                  15      


Leu Gln Lys Thr Leu Arg Phe Glu Leu Arg Pro Val Pro Glu Thr Lys 
            20                  25                  30          


Lys Leu Leu Glu Lys Gly Glu Gly Lys Asn Leu Ile Gln Met Asp Leu 
        35                  40                  45              


Glu Ile Asp Arg Leu Tyr Glu Lys Glu Met Lys Pro Met Phe Asn Ile 
    50                  55                  60                  


Leu His Glu Lys Phe Ile Asn Glu Ser Leu Gly Leu Val Lys Leu Asp 
65                  70                  75                  80  


Cys Lys Lys Leu Lys Lys Leu Glu Asn Leu Leu Ala Glu Ala Asp Lys 
                85                  90                  95      


Leu Arg Lys Gln Ile Lys Glu Gly Arg Lys Asn Lys Asn Asn Ile Ser 
            100                 105                 110         


Glu Val Glu Lys Arg Leu Lys Ile Ile Ile Gly Asp Asn Ser Gln Gly 
        115                 120                 125             


Lys Asn Lys Asn Gly Glu Ile Ala Val Leu Gln Asp Glu Leu Arg Val 
    130                 135                 140                 


Leu Ile Val Lys Ala Phe Asn Leu Thr Ala Asp Lys Trp Lys Lys Glu 
145                 150                 155                 160 


Leu Asn Asn Lys Glu Thr Leu Leu Pro Glu Lys Lys Gly Lys Arg Lys 
                165                 170                 175     


Ile Lys Ile Lys Lys Ser Gly Pro Lys Ile Leu Gln Glu Glu Asn Val 
            180                 185                 190         


Leu Ala Ile Leu Ala Tyr Phe Asn Pro Asp Lys Ala Asp Ile Ile Lys 
        195                 200                 205             


Lys Phe Ala Gly Phe Phe Thr Tyr Phe Ser Gly Phe Asn Gln Asn Arg 
    210                 215                 220                 


Ala Asn Tyr Tyr Thr Val Lys Ala Leu Ala Thr Gly Val Ala Asn Arg 
225                 230                 235                 240 


Ala Ile Asn Arg Asn Phe Leu Ile Phe Leu Ala Asn Arg Lys Asp Phe 
                245                 250                 255     


Ala Arg Phe Lys Glu Arg Leu Pro Arg Leu Ala Glu Phe Asp Asn Tyr 
            260                 265                 270         


Phe Glu Leu Glu Asn Tyr Glu Lys Tyr Leu Ser Gln Thr Gly Ile Glu 
        275                 280                 285             


Glu Tyr Asn Asp Gln Ile Gly Lys Ile Lys Gln Ile Val Asn Leu Glu 
    290                 295                 300                 


His Asn Gln Gln Gln Lys Asp Asn Lys Phe Gln Leu Lys Gly Leu Ala 
305                 310                 315                 320 


Thr Leu Glu Lys Gln Ile Gly Cys Arg Thr Lys Lys Gln Arg Glu Glu 
                325                 330                 335     


Gly Gly Asp Lys Ser Ala Pro Lys Phe Leu Glu Lys Val Gly Leu Gly 
            340                 345                 350         


Phe Gln Val Ser Gln Asp Asp Asp Gly Glu Tyr Leu Ile Trp Glu Cys 
        355                 360                 365             


Leu Asn Tyr Ile Asn Lys Glu Leu Ala Gly Lys Leu Lys Ser Ile Lys 
    370                 375                 380                 


Asp Asn Tyr Gln Lys Phe Phe Ala Asp Trp Arg Thr Gly Ala Tyr Asp 
385                 390                 395                 400 


Leu Glu Lys Ile Trp Phe Arg Lys Glu Ala Leu Asn Thr Ile Ser Gly 
                405                 410                 415     


Arg Trp Phe Gly Gly Asn Asn Trp Phe Ile Ile Gly Lys Ala Leu Ala 
            420                 425                 430         


Leu Thr Gly Val Gly Lys Phe Asp Lys Arg Glu Asn Thr Tyr Lys Ile 
        435                 440                 445             


Pro Glu Phe Val Ser Leu Ala Glu Ile Lys Thr Ala Phe Glu Met Leu 
    450                 455                 460                 


Glu Asn Gly Val Asn Tyr Asp Phe Lys Lys Ser Lys Lys Lys Lys Glu 
465                 470                 475                 480 


Gly Asp Asp Thr Asp Val Val Lys Tyr Ser Ala Asp Asn Leu Phe Lys 
                485                 490                 495     


Glu Glu Tyr Lys Lys Lys Gly Leu Ile Lys Asn Ser Leu Phe Glu Thr 
            500                 505                 510         


Met Leu Ala Val Trp Gln Ser Glu Ile Lys Arg Lys Phe Glu Gln Ile 
        515                 520                 525             


Phe Asp Gly Tyr Lys Leu Glu Lys Asp Asp Val Phe Gly Arg Lys Lys 
    530                 535                 540                 


Gly Glu Trp Val Glu Pro Phe Ile Glu Asn Phe Gln Lys Val Ser Gln 
545                 550                 555                 560 


Glu Lys Phe Asp Arg Gly Val Lys Asp Glu Asn Gly Arg Ser Ile His 
                565                 570                 575     


Thr Glu Val Val Lys Asn Leu Ile Glu Glu Gly Tyr Leu Arg Leu Phe 
            580                 585                 590         


Gln Leu Thr Lys Tyr His Asn Leu Asp Lys Lys Gly Glu Arg Asp Pro 
        595                 600                 605             


Arg Pro Phe Asp Gly Asn Phe Tyr Ala Thr Leu Asp Glu Phe Trp Lys 
    610                 615                 620                 


Asp Asn Ile Val Val Val Tyr His Lys Ala Leu Gln Ser Thr Leu Thr 
625                 630                 635                 640 


Lys Lys Pro Tyr Ser Glu Asp Lys Ile Lys Leu Asn Phe Glu Asn Gly 
                645                 650                 655     


Ser Leu Leu Gly Gly Phe Ser Asp Gly Gln Glu Arg Ser Lys Ala Gly 
            660                 665                 670         


Val Val Leu Lys Asn Lys Asn Lys Phe Tyr Leu Gly Ile Leu Ile Asp 
        675                 680                 685             


Arg Gly Phe Phe Arg Thr Asp Lys Ala Asn Pro Val Tyr Asp Asn Ala 
    690                 695                 700                 


Gln Asn Asn Glu Trp Glu Arg Leu Ile Leu Thr Asn Leu Lys Phe Gln 
705                 710                 715                 720 


Thr Leu Ala Gly Lys Gly Phe Leu Gly Lys His Gly Val Ser Tyr Gly 
                725                 730                 735     


Glu Met Gly Lys Asp Asn Pro Met Met Ala Val Glu Tyr Leu Gln Lys 
            740                 745                 750         


Phe Ile Lys Leu Lys Tyr Leu Asp Lys Tyr Pro Ala Leu Asn Glu Val 
        755                 760                 765             


Ala His Lys Lys Tyr Thr Ile Lys Lys Glu Phe Asp Ala Asp Val Lys 
    770                 775                 780                 


Asn Ala Leu Lys Asp Cys Phe Thr Met Asn Phe Lys Pro Val Asp Phe 
785                 790                 795                 800 


Gly Met Ile Arg Gln Gly Leu Thr Glu Ser Leu Phe Tyr Leu Phe Glu 
                805                 810                 815     


Ile Val Asn Lys Asp Ile Ser Ser Gln Ala Lys Asn Gly Lys Asn Val 
            820                 825                 830         


His Thr Leu Tyr Trp Glu Ala Leu Phe Gly Asp Gln Asn Leu Lys Lys 
        835                 840                 845             


Pro Ile Leu Ala Leu Asn Gly Gly Ala Glu Ile Phe Tyr Arg Glu Ser 
    850                 855                 860                 


Gln Arg Glu Lys Leu Glu Lys Lys Leu Asp Lys Ser Gly Lys Glu Val 
865                 870                 875                 880 


Leu Asp His Lys Arg Tyr Gly Gln Asp Lys Tyr Phe Leu His Ala Ser 
                885                 890                 895     


Ile Thr Ile Asn Tyr Gly Gln Pro Lys Asn Ile Lys Phe Lys Glu Val 
            900                 905                 910         


Ile Asn Glu Lys Ile Ser Gln Asn Ala Asp Arg Val Asn Ile Ile Gly 
        915                 920                 925             


Ile Asp Arg Gly Glu Lys His Leu Leu Tyr Tyr Ser Val Val Ser Pro 
    930                 935                 940                 


Glu Gly Val Leu Leu Glu Gln Gly Ser Phe Asn Gln Ile Glu Thr Lys 
945                 950                 955                 960 


Asn Lys Val Asp Ile Lys Ala Val Lys Ala Glu Tyr Gly Glu Arg Gly 
                965                 970                 975     


Glu Leu Lys Lys Val Glu Leu Val Pro Thr Gly Lys Lys Val Lys Tyr 
            980                 985                 990         


Val Asp Tyr Gln Ile Leu Leu Asp  Tyr Tyr Glu Lys Lys  Arg Asn Leu 
        995                 1000                 1005             


Ala Arg  Arg Asp Trp Gln Thr  Ile Gly Lys Ile Lys  Asp Leu Lys 
    1010                 1015                 1020             


Asp Gly  Tyr Leu Ser Gln Thr  Val His Arg Ile Tyr  Gln Leu Ile 
    1025                 1030                 1035             


Leu Lys  Tyr Asn Ala Val Val  Ala Met Glu Asp Leu  Asn Val Glu 
    1040                 1045                 1050             


Phe Lys  Ala Lys Arg Ala Ala  Lys Val Glu Lys Ser  Val Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Glu Met Ala Leu Ala  Lys Lys Leu Asn His  Leu Ile Leu 
    1070                 1075                 1080             


Lys Asp  Arg Arg Ala Asp Glu  Ile Gly Gly Ala Leu  Arg Ala Tyr 
    1085                 1090                 1095             


Gln Leu  Thr Pro Ala Ile Pro  Ala Asn Asp Val Gly  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ala  Lys Gln Trp Gly Ile  Met Phe Tyr Val Arg  Ala Asn Tyr 
    1115                 1120                 1125             


Thr Ser  Thr Thr Asp Pro Leu  Thr Gly Trp Arg Lys  His Lys Tyr 
    1130                 1135                 1140             


Ile Ser  Asn Ser Glu Lys Ile  Asp Asn Ile Gln Lys  Phe Phe Ser 
    1145                 1150                 1155             


Pro Gly  Asp Gly Ile Gln Ile  Asp Tyr Asp Thr Glu  Lys Gln Cys 
    1160                 1165                 1170             


Phe Lys  Phe Ser Tyr Asp His  Glu Leu Glu Gly Gly  Ala Lys Lys 
    1175                 1180                 1185             


His Trp  Glu Leu Phe Ala Cys  Asp Gly Leu Glu Arg  Phe Tyr Trp 
    1190                 1195                 1200             


Asp Asn  Arg Glu Arg Gln Ile  Lys Lys Tyr Asn Leu  Tyr Glu Glu 
    1205                 1210                 1215             


Phe Glu  Lys Leu Leu Gly Gly  Leu Arg Lys Glu Glu  Asn Ile Asn 
    1220                 1225                 1230             


Ile Gln  Ile Asp Gly Val Ser  Glu Phe Arg Trp Lys  Asp Leu Val 
    1235                 1240                 1245             


Phe Phe  Trp Asn Leu Leu Asn  Gln Ile Arg Asn Thr  Asp Arg Ser 
    1250                 1255                 1260             


Ala Gln  Gly Asp Glu Asn Asp  Phe Leu Gln Ser Pro  Val Trp Ser 
    1265                 1270                 1275             


Glu Lys  Tyr Asn Cys Phe Tyr  Asp Ser Arg Lys Ala  Pro Asn Asn 
    1280                 1285                 1290             


Met Pro  Asn Asn Gly Asp Ala  Asn Gly Ala Phe Asn  Ile Ala Arg 
    1295                 1300                 1305             


Lys Gly  Gln Leu Ile Leu Glu  Arg Ile Lys Lys Cys  Ser Asp Ile 
    1310                 1315                 1320             


Pro Lys  Phe Gly Asn Asp Asn  Asn Gly Lys Asn Pro  Glu Asn Asn 
    1325                 1330                 1335             


Tyr Phe  Ile Ser Asp Ala Asp  Trp Asp Lys Phe Ala  Gln Lys 
    1340                 1345                 1350         


<210> 589
<211> 1108
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 589
Met Ala Ile Arg Ser Ile Lys Leu Lys Leu Lys Thr His Thr Gly Pro 
1               5                   10                  15      


Glu Ala Gln Asn Leu Arg Lys Gly Ile Trp Arg Thr His Arg Leu Leu 
            20                  25                  30          


Asn Glu Gly Val Ala Tyr Tyr Met Lys Met Leu Leu Leu Phe Arg Gln 
        35                  40                  45              


Glu Ser Thr Gly Glu Arg Pro Lys Glu Glu Leu Gln Glu Glu Leu Ile 
    50                  55                  60                  


Cys His Ile Arg Glu Gln Gln Gln Arg Asn Gln Ala Asp Lys Asn Thr 
65                  70                  75                  80  


Gln Ala Leu Pro Leu Asp Lys Ala Leu Glu Ala Leu Arg Gln Leu Tyr 
                85                  90                  95      


Glu Leu Leu Val Pro Ser Ser Val Gly Gln Ser Gly Asp Ala Gln Ile 
            100                 105                 110         


Ile Ser Arg Lys Phe Leu Ser Pro Leu Val Asp Pro Asn Ser Glu Gly 
        115                 120                 125             


Gly Lys Gly Thr Ser Lys Ala Gly Ala Lys Pro Thr Trp Gln Lys Lys 
    130                 135                 140                 


Lys Glu Ala Asn Asp Pro Thr Trp Glu Gln Asp Tyr Glu Lys Trp Lys 
145                 150                 155                 160 


Lys Arg Arg Glu Glu Asp Pro Thr Ala Ser Val Ile Thr Thr Leu Glu 
                165                 170                 175     


Glu Tyr Gly Ile Arg Pro Ile Phe Pro Leu Tyr Thr Asn Thr Val Thr 
            180                 185                 190         


Asp Ile Ala Trp Leu Pro Leu Gln Ser Asn Gln Phe Val Arg Thr Trp 
        195                 200                 205             


Asp Arg Asp Met Leu Gln Gln Ala Ile Glu Arg Leu Leu Ser Trp Glu 
    210                 215                 220                 


Ser Trp Asn Lys Arg Val Gln Glu Glu Tyr Ala Lys Leu Lys Glu Lys 
225                 230                 235                 240 


Met Ala Gln Leu Asn Glu Gln Leu Glu Gly Gly Gln Glu Trp Ile Ser 
                245                 250                 255     


Leu Leu Glu Gln Tyr Glu Glu Asn Arg Glu Arg Glu Leu Arg Glu Asn 
            260                 265                 270         


Met Thr Ala Ala Asn Asp Lys Tyr Arg Ile Thr Lys Arg Gln Met Lys 
        275                 280                 285             


Gly Trp Asn Glu Leu Tyr Glu Leu Trp Ser Thr Phe Pro Ala Ser Ala 
    290                 295                 300                 


Ser His Glu Gln Tyr Lys Glu Ala Leu Lys Arg Val Gln Gln Arg Leu 
305                 310                 315                 320 


Arg Gly Arg Phe Gly Asp Ala His Phe Phe Gln Tyr Leu Met Glu Glu 
                325                 330                 335     


Lys Asn Arg Leu Ile Trp Lys Gly Asn Pro Gln Arg Ile His Tyr Phe 
            340                 345                 350         


Val Ala Arg Asn Glu Leu Thr Lys Arg Leu Glu Glu Ala Lys Gln Ser 
        355                 360                 365             


Ala Thr Met Thr Leu Pro Asn Ala Arg Lys His Pro Leu Trp Val Arg 
    370                 375                 380                 


Phe Asp Ala Arg Gly Gly Asn Leu Gln Asp Tyr Tyr Leu Thr Ala Glu 
385                 390                 395                 400 


Ala Asp Lys Pro Arg Ser Arg Arg Phe Val Thr Phe Ser Gln Leu Ile 
                405                 410                 415     


Trp Pro Ser Glu Ser Gly Trp Met Glu Lys Lys Asp Val Glu Val Glu 
            420                 425                 430         


Leu Ala Leu Ser Arg Gln Phe Tyr Gln Gln Val Lys Leu Leu Lys Asn 
        435                 440                 445             


Asp Lys Gly Lys Gln Lys Ile Glu Phe Lys Asp Lys Gly Ser Gly Ser 
    450                 455                 460                 


Thr Phe Asn Gly His Leu Gly Gly Ala Lys Leu Gln Leu Glu Arg Gly 
465                 470                 475                 480 


Asp Leu Glu Lys Glu Glu Lys Asn Phe Glu Asp Gly Glu Ile Gly Ser 
                485                 490                 495     


Val Tyr Leu Asn Val Val Ile Asp Phe Glu Pro Leu Gln Glu Val Lys 
            500                 505                 510         


Asn Gly Arg Val Gln Ala Pro Tyr Gly Gln Val Leu Gln Leu Ile Arg 
        515                 520                 525             


Arg Pro Asn Glu Phe Pro Lys Val Thr Thr Tyr Lys Ser Glu Gln Leu 
    530                 535                 540                 


Val Glu Trp Ile Lys Ala Ser Pro Gln His Ser Ala Gly Val Glu Ser 
545                 550                 555                 560 


Leu Ala Ser Gly Phe Arg Val Met Ser Ile Asp Leu Gly Leu Arg Ala 
                565                 570                 575     


Ala Ala Ala Thr Ser Ile Phe Ser Val Glu Glu Ser Ser Asp Lys Asn 
            580                 585                 590         


Ala Ala Asp Phe Ser Tyr Trp Ile Glu Gly Thr Pro Leu Val Ala Val 
        595                 600                 605             


His Gln Arg Ser Tyr Met Leu Arg Leu Pro Gly Glu Gln Val Glu Lys 
    610                 615                 620                 


Gln Val Met Glu Lys Arg Asp Glu Arg Phe Gln Leu His Gln Arg Val 
625                 630                 635                 640 


Lys Phe Gln Ile Arg Val Leu Ala Gln Ile Met Arg Met Ala Asn Lys 
                645                 650                 655     


Gln Tyr Gly Asp Arg Trp Asp Glu Leu Asp Ser Leu Lys Gln Ala Val 
            660                 665                 670         


Glu Gln Lys Lys Ser Pro Leu Asp Gln Thr Asp Arg Thr Phe Trp Glu 
        675                 680                 685             


Gly Ile Val Cys Asp Leu Thr Lys Val Leu Pro Arg Asn Glu Ala Asp 
    690                 695                 700                 


Trp Glu Gln Ala Val Val Gln Ile His Arg Lys Ala Glu Glu Tyr Val 
705                 710                 715                 720 


Gly Lys Ala Val Gln Ala Trp Arg Lys Arg Phe Ala Ala Asp Glu Arg 
                725                 730                 735     


Lys Gly Ile Ala Gly Leu Ser Met Trp Asn Ile Glu Glu Leu Glu Gly 
            740                 745                 750         


Leu Arg Lys Leu Leu Ile Ser Trp Ser Arg Arg Thr Arg Asn Pro Gln 
        755                 760                 765             


Glu Val Asn Arg Phe Glu Arg Gly His Thr Ser His Gln Arg Leu Leu 
    770                 775                 780                 


Thr His Ile Gln Asn Val Lys Glu Asp Arg Leu Lys Gln Leu Ser His 
785                 790                 795                 800 


Ala Ile Val Met Thr Ala Leu Gly Tyr Val Tyr Asp Glu Arg Lys Gln 
                805                 810                 815     


Glu Trp Cys Ala Glu Tyr Pro Ala Cys Gln Val Ile Leu Phe Glu Asn 
            820                 825                 830         


Leu Ser Gln Tyr Arg Ser Asn Leu Asp Arg Ser Thr Lys Glu Asn Ser 
        835                 840                 845             


Thr Leu Met Lys Trp Ala His Arg Ser Ile Pro Lys Tyr Val His Met 
    850                 855                 860                 


Gln Ala Glu Pro Tyr Gly Ile Gln Ile Gly Asp Val Arg Ala Glu Tyr 
865                 870                 875                 880 


Ser Ser Arg Phe Tyr Ala Lys Thr Gly Thr Pro Gly Ile Arg Cys Lys 
                885                 890                 895     


Lys Val Arg Gly Gln Asp Leu Gln Gly Arg Arg Phe Glu Asn Leu Gln 
            900                 905                 910         


Lys Arg Leu Val Asn Glu Gln Phe Leu Thr Glu Glu Gln Val Lys Gln 
        915                 920                 925             


Leu Arg Pro Gly Asp Ile Val Pro Asp Asp Ser Gly Glu Leu Phe Met 
    930                 935                 940                 


Thr Leu Thr Asp Gly Ser Gly Ser Lys Glu Val Val Phe Leu Gln Ala 
945                 950                 955                 960 


Asp Ile Asn Ala Ala His Asn Leu Gln Lys Arg Phe Trp Gln Arg Tyr 
                965                 970                 975     


Asn Glu Leu Phe Lys Val Ser Cys Arg Val Ile Val Arg Asp Glu Glu 
            980                 985                 990         


Glu Tyr Leu Val Pro Lys Thr Lys  Ser Val Gln Ala Lys  Leu Gly Lys 
        995                 1000                 1005             


Gly Leu  Phe Val Lys Lys Ser  Asp Thr Ala Trp Lys  Asp Val Tyr 
    1010                 1015                 1020             


Val Trp  Asp Ser Gln Ala Lys  Leu Lys Gly Lys Thr  Thr Phe Thr 
    1025                 1030                 1035             


Glu Glu  Ser Glu Ser Pro Glu  Gln Leu Glu Asp Phe  Gln Glu Ile 
    1040                 1045                 1050             


Ile Glu  Glu Ala Glu Glu Ala  Lys Gly Thr Tyr Arg  Thr Leu Phe 
    1055                 1060                 1065             


Arg Asp  Pro Ser Gly Val Phe  Phe Pro Glu Ser Val  Trp Tyr Pro 
    1070                 1075                 1080             


Gln Lys  Asp Phe Trp Gly Glu  Val Lys Arg Lys Leu  Tyr Gly Lys 
    1085                 1090                 1095             


Leu Arg  Glu Arg Phe Leu Thr  Lys Ala Arg 
    1100                 1105             


<210> 590
<211> 1125
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 590
Met Arg Lys Lys Leu Phe Lys Gly Tyr Ile Leu His Asn Lys Arg Leu 
1               5                   10                  15      


Val Tyr Thr Gly Lys Ala Ala Ile Arg Ser Ile Lys Tyr Pro Leu Val 
            20                  25                  30          


Ala Pro Asn Lys Thr Ala Leu Asn Asn Leu Ser Glu Lys Ile Ile Tyr 
        35                  40                  45              


Asp Tyr Glu His Leu Phe Gly Pro Leu Asn Val Ala Ser Tyr Ala Arg 
    50                  55                  60                  


Asn Ser Asn Arg Tyr Ser Leu Val Asp Phe Trp Ile Asp Ser Leu Arg 
65                  70                  75                  80  


Ala Gly Val Ile Trp Gln Ser Lys Ser Thr Ser Leu Ile Asp Leu Ile 
                85                  90                  95      


Ser Lys Leu Glu Gly Ser Lys Ser Pro Ser Glu Lys Ile Phe Glu Gln 
            100                 105                 110         


Ile Asp Phe Glu Leu Lys Asn Lys Leu Asp Lys Glu Gln Phe Lys Asp 
        115                 120                 125             


Ile Ile Leu Leu Asn Thr Gly Ile Arg Ser Ser Ser Asn Val Arg Ser 
    130                 135                 140                 


Leu Arg Gly Arg Phe Leu Lys Cys Phe Lys Glu Glu Phe Arg Asp Thr 
145                 150                 155                 160 


Glu Glu Val Ile Ala Cys Val Asp Lys Trp Ser Lys Asp Leu Ile Val 
                165                 170                 175     


Glu Gly Lys Ser Ile Leu Val Ser Lys Gln Phe Leu Tyr Trp Glu Glu 
            180                 185                 190         


Glu Phe Gly Ile Lys Ile Phe Pro His Phe Lys Asp Asn His Asp Leu 
        195                 200                 205             


Pro Lys Leu Thr Phe Phe Val Glu Pro Ser Leu Glu Phe Ser Pro His 
    210                 215                 220                 


Leu Pro Leu Ala Asn Cys Leu Glu Arg Leu Lys Lys Phe Asp Ile Ser 
225                 230                 235                 240 


Arg Glu Ser Leu Leu Gly Leu Asp Asn Asn Phe Ser Ala Phe Ser Asn 
                245                 250                 255     


Tyr Phe Asn Glu Leu Phe Asn Leu Leu Ser Arg Gly Glu Ile Lys Lys 
            260                 265                 270         


Ile Val Thr Ala Val Leu Ala Val Ser Lys Ser Trp Glu Asn Glu Pro 
        275                 280                 285             


Glu Leu Glu Lys Arg Leu His Phe Leu Ser Glu Lys Ala Lys Leu Leu 
    290                 295                 300                 


Gly Tyr Pro Lys Leu Thr Ser Ser Trp Ala Asp Tyr Arg Met Ile Ile 
305                 310                 315                 320 


Gly Gly Lys Ile Lys Ser Trp His Ser Asn Tyr Thr Glu Gln Leu Ile 
                325                 330                 335     


Lys Val Arg Glu Asp Leu Lys Lys His Gln Ile Ala Leu Asp Lys Leu 
            340                 345                 350         


Gln Glu Asp Leu Lys Lys Val Val Asp Ser Ser Leu Arg Glu Gln Ile 
        355                 360                 365             


Glu Ala Gln Arg Glu Ala Leu Leu Pro Leu Leu Asp Thr Met Leu Lys 
    370                 375                 380                 


Glu Lys Asp Phe Ser Asp Asp Leu Glu Leu Tyr Arg Phe Ile Leu Ser 
385                 390                 395                 400 


Asp Phe Lys Ser Leu Leu Asn Gly Ser Tyr Gln Arg Tyr Ile Gln Thr 
                405                 410                 415     


Glu Glu Glu Arg Lys Glu Asp Arg Asp Val Thr Lys Lys Tyr Lys Asp 
            420                 425                 430         


Leu Tyr Ser Asn Leu Arg Asn Ile Pro Arg Phe Phe Gly Glu Ser Lys 
        435                 440                 445             


Lys Glu Gln Phe Asn Lys Phe Ile Asn Lys Ser Leu Pro Thr Ile Asp 
    450                 455                 460                 


Val Gly Leu Lys Ile Leu Glu Asp Ile Arg Asn Ala Leu Glu Thr Val 
465                 470                 475                 480 


Ser Val Arg Lys Pro Pro Ser Ile Thr Glu Glu Tyr Val Thr Lys Gln 
                485                 490                 495     


Leu Glu Lys Leu Ser Arg Lys Tyr Lys Ile Asn Ala Phe Asn Ser Asn 
            500                 505                 510         


Arg Phe Lys Gln Ile Thr Glu Gln Val Leu Arg Lys Tyr Asn Asn Gly 
        515                 520                 525             


Glu Leu Pro Lys Ile Ser Glu Val Phe Tyr Arg Tyr Pro Arg Glu Ser 
    530                 535                 540                 


His Val Ala Ile Arg Ile Leu Pro Val Lys Ile Ser Asn Pro Arg Lys 
545                 550                 555                 560 


Asp Ile Ser Tyr Leu Leu Asp Lys Tyr Gln Ile Ser Pro Asp Trp Lys 
                565                 570                 575     


Asn Ser Asn Pro Gly Glu Val Val Asp Leu Ile Glu Ile Tyr Lys Leu 
            580                 585                 590         


Thr Leu Gly Trp Leu Leu Ser Cys Asn Lys Asp Phe Ser Met Asp Phe 
        595                 600                 605             


Ser Ser Tyr Asp Leu Lys Leu Phe Pro Glu Ala Ala Ser Leu Ile Lys 
    610                 615                 620                 


Asn Phe Gly Ser Cys Leu Ser Gly Tyr Tyr Leu Ser Lys Met Ile Phe 
625                 630                 635                 640 


Asn Cys Ile Thr Ser Glu Ile Lys Gly Met Ile Thr Leu Tyr Thr Arg 
                645                 650                 655     


Asp Lys Phe Val Val Arg Tyr Val Thr Gln Met Ile Gly Ser Asn Gln 
            660                 665                 670         


Lys Phe Pro Leu Leu Cys Leu Val Gly Glu Lys Gln Thr Lys Asn Phe 
        675                 680                 685             


Ser Arg Asn Trp Gly Val Leu Ile Glu Glu Lys Gly Asp Leu Gly Glu 
    690                 695                 700                 


Glu Lys Asn Gln Glu Lys Cys Leu Ile Phe Lys Asp Lys Thr Asp Phe 
705                 710                 715                 720 


Ala Lys Ala Lys Glu Val Glu Ile Phe Lys Asn Asn Ile Trp Arg Ile 
                725                 730                 735     


Arg Thr Ser Lys Tyr Gln Ile Gln Phe Leu Asn Arg Leu Phe Lys Lys 
            740                 745                 750         


Thr Lys Glu Trp Asp Leu Met Asn Leu Val Leu Ser Glu Pro Ser Leu 
        755                 760                 765             


Val Leu Glu Glu Glu Trp Gly Val Ser Trp Asp Lys Asp Lys Leu Leu 
    770                 775                 780                 


Pro Leu Leu Lys Lys Glu Lys Ser Cys Glu Glu Arg Leu Tyr Tyr Ser 
785                 790                 795                 800 


Leu Pro Leu Asn Leu Val Pro Ala Thr Asp Tyr Lys Glu Gln Ser Ala 
                805                 810                 815     


Glu Ile Glu Gln Arg Asn Thr Tyr Leu Gly Leu Asp Val Gly Glu Phe 
            820                 825                 830         


Gly Val Ala Tyr Ala Val Val Arg Ile Val Arg Asp Arg Ile Glu Leu 
        835                 840                 845             


Leu Ser Trp Gly Phe Leu Lys Asp Pro Ala Leu Arg Lys Ile Arg Glu 
    850                 855                 860                 


Arg Val Gln Asp Met Lys Lys Lys Gln Val Met Ala Val Phe Ser Ser 
865                 870                 875                 880 


Ser Ser Thr Ala Val Ala Arg Val Arg Glu Met Ala Ile His Ser Leu 
                885                 890                 895     


Arg Asn Gln Ile His Ser Ile Ala Leu Ala Tyr Lys Ala Lys Ile Ile 
            900                 905                 910         


Tyr Glu Ile Ser Ile Ser Asn Phe Glu Thr Gly Gly Asn Arg Met Ala 
        915                 920                 925             


Lys Ile Tyr Arg Ser Ile Lys Val Ser Asp Val Tyr Arg Glu Ser Gly 
    930                 935                 940                 


Ala Asp Thr Leu Val Ser Glu Met Ile Trp Gly Lys Lys Asn Lys Gln 
945                 950                 955                 960 


Met Gly Asn His Ile Ser Ser Tyr Ala Thr Ser Tyr Thr Cys Cys Asn 
                965                 970                 975     


Cys Ala Arg Thr Pro Phe Glu Leu Val Ile Asp Asn Asp Lys Glu Tyr 
            980                 985                 990         


Glu Lys Gly Gly Asp Glu Phe Ile  Phe Asn Val Gly Asp  Glu Lys Lys 
        995                 1000                 1005             


Val Arg  Gly Phe Leu Gln Lys  Ser Leu Leu Gly Lys  Thr Ile Lys 
    1010                 1015                 1020             


Gly Lys  Glu Val Leu Lys Ser  Ile Lys Glu Tyr Ala  Arg Pro Pro 
    1025                 1030                 1035             


Ile Arg  Glu Val Leu Leu Glu  Gly Glu Asp Val Glu  Gln Leu Leu 
    1040                 1045                 1050             


Lys Arg  Arg Gly Asn Ser Tyr  Ile Tyr Arg Cys Pro  Phe Cys Gly 
    1055                 1060                 1065             


Tyr Lys  Thr Asp Ala Asp Ile  Gln Ala Ala Leu Asn  Ile Ala Cys 
    1070                 1075                 1080             


Arg Gly  Tyr Ile Ser Asp Asn  Ala Lys Asp Ala Val  Lys Glu Gly 
    1085                 1090                 1095             


Glu Arg  Lys Leu Asp Tyr Ile  Leu Glu Val Arg Lys  Leu Trp Glu 
    1100                 1105                 1110             


Lys Asn  Gly Ala Val Leu Arg  Ser Ala Lys Phe Leu  
    1115                 1120                 1125 


<210> 591
<211> 1352
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 591
Met Ser Thr Gln Lys Asn Pro Phe Asn Gln Phe Thr Asn Leu Tyr Glu 
1               5                   10                  15      


Leu Gln Lys Thr Leu Arg Phe Glu Leu Arg Pro Val Pro Glu Thr Lys 
            20                  25                  30          


Lys Leu Leu Glu Lys Gly Glu Gly Lys Asn Leu Ile Gln Met Asp Leu 
        35                  40                  45              


Glu Ile Asp Arg Leu Tyr Glu Lys Glu Met Lys Pro Met Phe Asn Ile 
    50                  55                  60                  


Leu His Glu Lys Phe Ile Asn Glu Ser Leu Gly Leu Val Lys Leu Asp 
65                  70                  75                  80  


Cys Lys Lys Leu Lys Lys Leu Glu Asn Leu Leu Ala Glu Ala Asp Lys 
                85                  90                  95      


Leu Arg Lys Gln Ile Lys Glu Gly Arg Lys Asn Lys Asn Asn Ile Ser 
            100                 105                 110         


Glu Val Glu Lys Arg Leu Lys Ile Ile Ile Gly Asp Asn Ser Gln Gly 
        115                 120                 125             


Lys Asn Lys Asn Gly Glu Ile Ala Val Leu Gln Asp Glu Leu Arg Val 
    130                 135                 140                 


Leu Ile Val Lys Ala Phe Asn Leu Thr Ala Asp Lys Trp Lys Lys Glu 
145                 150                 155                 160 


Leu Asn Asn Lys Glu Thr Leu Leu Pro Glu Lys Lys Gly Lys Arg Lys 
                165                 170                 175     


Ile Lys Ile Lys Lys Ser Gly Pro Lys Ile Leu Gln Glu Glu Asn Val 
            180                 185                 190         


Leu Ala Ile Leu Ala Tyr Phe Asn Pro Asp Lys Ala Asp Ile Ile Lys 
        195                 200                 205             


Lys Phe Ala Gly Phe Phe Thr Tyr Phe Ser Gly Phe Asn Gln Asn Arg 
    210                 215                 220                 


Ala Asn Tyr Tyr Thr Val Lys Ala Leu Ala Thr Gly Val Ala Asn Arg 
225                 230                 235                 240 


Ala Ile Asn Arg Asn Phe Leu Ile Phe Leu Ala Asn Arg Lys Asp Phe 
                245                 250                 255     


Ala Arg Phe Lys Glu Arg Leu Pro Arg Leu Ala Glu Phe Asp Asn Tyr 
            260                 265                 270         


Phe Glu Leu Glu Asn Tyr Glu Lys Tyr Leu Ser Gln Thr Gly Ile Glu 
        275                 280                 285             


Glu Tyr Asn Asp Gln Ile Gly Lys Ile Lys Gln Ile Val Asn Leu Glu 
    290                 295                 300                 


His Asn Gln Gln Gln Lys Asp Asn Lys Phe Gln Leu Lys Gly Leu Ala 
305                 310                 315                 320 


Thr Leu Glu Lys Gln Ile Gly Cys Arg Thr Lys Lys Gln Arg Glu Glu 
                325                 330                 335     


Gly Gly Asp Lys Ser Ala Pro Lys Phe Leu Glu Lys Val Gly Leu Gly 
            340                 345                 350         


Phe Gln Val Ser Gln Asp Asp Asp Gly Glu Tyr Leu Ile Trp Glu Cys 
        355                 360                 365             


Leu Asn Tyr Ile Asn Lys Glu Leu Ala Gly Lys Leu Lys Ser Ile Lys 
    370                 375                 380                 


Asp Asn Tyr Gln Lys Phe Phe Ala Asp Trp Arg Thr Gly Ala Tyr Asp 
385                 390                 395                 400 


Leu Glu Lys Ile Trp Phe Arg Lys Glu Ala Leu Asn Thr Ile Ser Gly 
                405                 410                 415     


Arg Trp Phe Gly Gly Asn Asn Trp Phe Ile Ile Gly Lys Ala Leu Ala 
            420                 425                 430         


Leu Thr Gly Val Gly Lys Phe Asp Lys Arg Glu Asn Thr Tyr Lys Ile 
        435                 440                 445             


Pro Glu Phe Val Ser Leu Ala Glu Ile Lys Thr Ala Phe Glu Met Leu 
    450                 455                 460                 


Glu Asn Gly Val Asn Tyr Asp Phe Lys Lys Ser Lys Lys Lys Lys Glu 
465                 470                 475                 480 


Gly Asp Asp Thr Asp Val Val Lys Tyr Ser Ala Asp Asn Leu Phe Lys 
                485                 490                 495     


Glu Glu Tyr Lys Lys Lys Gly Leu Ile Lys Asn Ser Leu Phe Glu Thr 
            500                 505                 510         


Met Leu Ala Val Trp Gln Ser Glu Ile Lys Arg Lys Phe Glu Gln Ile 
        515                 520                 525             


Phe Asp Gly Tyr Lys Leu Glu Lys Asp Asp Val Phe Gly Arg Lys Lys 
    530                 535                 540                 


Gly Glu Trp Val Glu Pro Phe Ile Glu Asn Phe Gln Lys Val Ser Gln 
545                 550                 555                 560 


Glu Lys Phe Asp Arg Gly Val Lys Asp Glu Asn Gly Arg Ser Ile His 
                565                 570                 575     


Thr Glu Val Val Lys Asn Leu Ile Glu Glu Gly Tyr Leu Arg Leu Phe 
            580                 585                 590         


Gln Leu Thr Lys Tyr His Asn Leu Asp Lys Lys Gly Glu Arg Asp Pro 
        595                 600                 605             


Arg Pro Phe Asp Gly Asn Phe Tyr Ala Thr Leu Asp Glu Phe Trp Lys 
    610                 615                 620                 


Asp Asn Ile Val Val Val Tyr His Lys Ala Leu Gln Ser Thr Leu Thr 
625                 630                 635                 640 


Lys Lys Pro Tyr Ser Glu Asp Lys Ile Lys Leu Asn Phe Glu Asn Gly 
                645                 650                 655     


Ser Leu Leu Gly Gly Phe Ser Asp Gly Gln Glu Arg Ser Lys Ala Gly 
            660                 665                 670         


Val Val Leu Lys Asn Lys Asn Lys Phe Tyr Leu Gly Ile Leu Ile Asp 
        675                 680                 685             


Arg Gly Phe Phe Arg Thr Asp Lys Ala Asn Pro Val Tyr Asp Asn Ala 
    690                 695                 700                 


Gln Asn Asn Glu Trp Glu Arg Leu Ile Leu Thr Asn Leu Lys Phe Gln 
705                 710                 715                 720 


Thr Leu Ala Gly Lys Gly Phe Leu Gly Lys His Gly Val Ser Tyr Gly 
                725                 730                 735     


Glu Met Gly Lys Asp Asn Pro Met Met Ala Val Glu Tyr Leu Gln Lys 
            740                 745                 750         


Phe Ile Lys Leu Lys Tyr Leu Asp Lys Tyr Pro Ala Leu Asn Glu Val 
        755                 760                 765             


Ala His Lys Lys Tyr Thr Ile Lys Lys Glu Phe Asp Ala Asp Val Lys 
    770                 775                 780                 


Asn Ala Leu Lys Asp Cys Phe Thr Met Asn Phe Lys Pro Val Asp Phe 
785                 790                 795                 800 


Gly Met Ile Arg Gln Gly Leu Thr Glu Ser Leu Phe Tyr Leu Phe Glu 
                805                 810                 815     


Ile Val Asn Lys Asp Ile Ser Ser Gln Ala Lys Asn Gly Lys Asn Val 
            820                 825                 830         


His Thr Leu Tyr Trp Glu Ala Leu Phe Gly Asp Gln Asn Leu Lys Lys 
        835                 840                 845             


Pro Ile Leu Ala Leu Asn Gly Gly Ala Glu Ile Phe Tyr Arg Glu Ser 
    850                 855                 860                 


Gln Arg Glu Lys Leu Glu Lys Lys Leu Asp Lys Ser Gly Lys Glu Val 
865                 870                 875                 880 


Leu Asp His Lys Arg Tyr Gly Gln Asp Lys Tyr Phe Leu His Ala Ser 
                885                 890                 895     


Ile Thr Ile Asn Tyr Gly Gln Pro Lys Asn Ile Lys Phe Lys Glu Val 
            900                 905                 910         


Ile Asn Glu Lys Ile Ser Gln Asn Ala Asp Arg Val Asn Ile Ile Gly 
        915                 920                 925             


Ile Asp Arg Gly Glu Lys His Leu Leu Tyr Tyr Ser Val Val Ser Pro 
    930                 935                 940                 


Glu Gly Val Leu Leu Glu Gln Gly Ser Phe Asn Gln Ile Glu Thr Lys 
945                 950                 955                 960 


Asn Lys Val Asp Ile Lys Ala Val Lys Ala Glu Tyr Gly Glu Arg Gly 
                965                 970                 975     


Glu Leu Lys Lys Val Glu Leu Val Pro Thr Gly Lys Lys Val Lys Tyr 
            980                 985                 990         


Val Asp Tyr Gln Ile Leu Leu Asp  Tyr Tyr Glu Lys Lys  Arg Asn Leu 
        995                 1000                 1005             


Ala Arg  Arg Asp Trp Gln Thr  Ile Gly Lys Ile Lys  Asp Leu Lys 
    1010                 1015                 1020             


Asp Gly  Tyr Leu Ser Gln Thr  Val His Arg Ile Tyr  Gln Leu Ile 
    1025                 1030                 1035             


Leu Lys  Tyr Asn Ala Val Val  Ala Met Glu Asp Leu  Asn Val Glu 
    1040                 1045                 1050             


Phe Lys  Ala Lys Arg Ala Ala  Lys Val Glu Lys Ser  Val Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Glu Met Ala Leu Ala  Lys Lys Leu Asn His  Leu Ile Leu 
    1070                 1075                 1080             


Lys Asp  Arg Arg Ala Asp Glu  Ile Gly Gly Ala Leu  Arg Ala Tyr 
    1085                 1090                 1095             


Gln Leu  Thr Pro Ala Ile Pro  Ala Asn Asp Val Gly  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ala  Lys Gln Trp Gly Ile  Met Phe Tyr Val Arg  Ala Asn Tyr 
    1115                 1120                 1125             


Thr Ser  Thr Thr Asp Pro Leu  Thr Gly Trp Arg Lys  His Lys Tyr 
    1130                 1135                 1140             


Ile Ser  Asn Ser Glu Lys Ile  Asp Asn Ile Gln Lys  Phe Phe Ser 
    1145                 1150                 1155             


Pro Gly  Asp Gly Ile Gln Ile  Asp Tyr Asp Thr Glu  Lys Gln Cys 
    1160                 1165                 1170             


Phe Lys  Phe Ser Tyr Asp His  Glu Leu Glu Gly Gly  Ala Lys Lys 
    1175                 1180                 1185             


His Trp  Glu Leu Phe Ala Cys  Asp Gly Leu Glu Arg  Phe Tyr Trp 
    1190                 1195                 1200             


Asp Asn  Arg Glu Arg Gln Ile  Lys Lys Tyr Asn Leu  Tyr Glu Glu 
    1205                 1210                 1215             


Phe Glu  Lys Leu Leu Gly Gly  Leu Arg Lys Glu Glu  Asn Ile Asn 
    1220                 1225                 1230             


Ile Gln  Ile Asp Gly Val Ser  Glu Phe Arg Trp Lys  Asp Leu Val 
    1235                 1240                 1245             


Phe Phe  Trp Asn Leu Leu Asn  Gln Ile Arg Asn Thr  Asp Arg Ser 
    1250                 1255                 1260             


Ala Gln  Gly Asp Glu Asn Asp  Phe Leu Gln Ser Pro  Val Trp Ser 
    1265                 1270                 1275             


Glu Lys  Tyr Asn Cys Phe Tyr  Asp Ser Arg Lys Ala  Pro Asn Asn 
    1280                 1285                 1290             


Met Pro  Asn Asn Gly Asp Ala  Asn Gly Ala Phe Asn  Ile Ala Arg 
    1295                 1300                 1305             


Lys Gly  Gln Leu Ile Leu Glu  Arg Ile Lys Lys Cys  Ser Asp Ile 
    1310                 1315                 1320             


Pro Lys  Phe Gly Asn Asp Asn  Asn Gly Lys Asn Pro  Glu Asn Asn 
    1325                 1330                 1335             


Tyr Phe  Ile Ser Asp Ala Asp  Trp Asp Lys Phe Ala  Gln Lys 
    1340                 1345                 1350         


<210> 592
<211> 767
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 592
Met Ala Gln Ala Ser Ser Thr Pro Ala Val Ser Pro Arg Pro Arg Pro 
1               5                   10                  15      


Arg Tyr Arg Glu Glu Arg Thr Leu Val Arg Lys Leu Leu Pro Arg Pro 
            20                  25                  30          


Gly Gln Ser Lys Gln Glu Phe Arg Glu Asn Val Lys Lys Leu Arg Lys 
        35                  40                  45              


Ala Phe Leu Gln Phe Asn Ala Asp Val Ser Gly Val Cys Gln Trp Ala 
    50                  55                  60                  


Ile Gln Phe Arg Pro Arg Tyr Gly Lys Pro Ala Glu Pro Thr Glu Thr 
65                  70                  75                  80  


Phe Trp Lys Phe Phe Leu Glu Pro Glu Thr Ser Leu Pro Pro Asn Asp 
                85                  90                  95      


Ser Arg Ser Pro Glu Phe Arg Arg Leu Gln Ala Phe Glu Ala Ala Ala 
            100                 105                 110         


Gly Ile Asn Gly Ala Ala Ala Leu Asp Asp Pro Ala Phe Thr Asn Glu 
        115                 120                 125             


Leu Arg Asp Ser Ile Leu Ala Val Ala Ser Arg Pro Lys Thr Lys Glu 
    130                 135                 140                 


Ala Gln Arg Leu Phe Ser Arg Leu Lys Asp Tyr Gln Pro Ala His Arg 
145                 150                 155                 160 


Met Ile Leu Ala Lys Val Ala Ala Glu Trp Ile Glu Ser Arg Tyr Arg 
                165                 170                 175     


Arg Ala His Gln Asn Trp Glu Arg Asn Tyr Glu Glu Trp Lys Lys Glu 
            180                 185                 190         


Lys Gln Glu Trp Glu Gln Asn His Pro Glu Leu Thr Pro Glu Ile Arg 
        195                 200                 205             


Glu Ala Phe Asn Gln Ile Phe Gln Gln Leu Glu Val Lys Glu Lys Arg 
    210                 215                 220                 


Val Arg Ile Cys Pro Ala Ala Arg Leu Leu Gln Asn Lys Asp Asn Cys 
225                 230                 235                 240 


Gln Tyr Ala Gly Lys Asn Lys His Ser Val Leu Cys Asn Gln Phe Asn 
                245                 250                 255     


Glu Phe Lys Lys Asn His Leu Gln Gly Lys Ala Ile Lys Phe Phe Tyr 
            260                 265                 270         


Lys Asp Ala Glu Lys Tyr Leu Arg Cys Gly Leu Gln Ser Leu Lys Pro 
        275                 280                 285             


Asn Val Gln Gly Pro Phe Arg Glu Asp Trp Asn Lys Tyr Leu Arg Tyr 
    290                 295                 300                 


Met Asn Leu Lys Glu Glu Thr Leu Arg Gly Lys Asn Gly Gly Arg Leu 
305                 310                 315                 320 


Pro His Cys Lys Asn Leu Gly Gln Glu Cys Glu Phe Asn Pro His Thr 
                325                 330                 335     


Ala Leu Cys Lys Gln Tyr Gln Gln Gln Leu Ser Ser Arg Pro Asp Leu 
            340                 345                 350         


Val Gln His Asp Glu Leu Tyr Arg Lys Trp Arg Arg Glu Tyr Trp Arg 
        355                 360                 365             


Glu Pro Arg Lys Pro Val Phe Arg Tyr Pro Ser Val Lys Arg His Ser 
    370                 375                 380                 


Ile Ala Lys Ile Phe Gly Glu Asn Tyr Phe Gln Ala Asp Phe Lys Asn 
385                 390                 395                 400 


Ser Val Val Gly Leu Arg Leu Asp Ser Met Pro Ala Gly Gln Tyr Leu 
                405                 410                 415     


Glu Phe Ala Phe Ala Pro Trp Pro Arg Asn Tyr Arg Pro Gln Pro Gly 
            420                 425                 430         


Glu Thr Glu Ile Ser Ser Val His Leu His Phe Val Gly Thr Arg Pro 
        435                 440                 445             


Arg Ile Gly Phe Arg Phe Arg Val Pro His Lys Arg Ser Arg Phe Asp 
    450                 455                 460                 


Cys Thr Gln Glu Glu Leu Asp Glu Leu Arg Ser Arg Thr Phe Pro Arg 
465                 470                 475                 480 


Lys Ala Gln Asp Gln Lys Phe Leu Glu Ala Ala Arg Lys Arg Leu Leu 
                485                 490                 495     


Glu Thr Phe Pro Gly Asn Ala Glu Gln Glu Leu Arg Leu Leu Ala Val 
            500                 505                 510         


Asp Leu Gly Thr Asp Ser Ala Arg Ala Ala Phe Phe Ile Gly Lys Thr 
        515                 520                 525             


Phe Gln Gln Ala Phe Pro Leu Lys Ile Val Lys Ile Glu Lys Leu Tyr 
    530                 535                 540                 


Glu Gln Trp Pro Asn Gln Lys Gln Ala Gly Asp Arg Arg Asp Ala Ser 
545                 550                 555                 560 


Ser Lys Gln Pro Arg Pro Gly Leu Ser Arg Asp His Val Gly Arg His 
                565                 570                 575     


Leu Gln Lys Met Arg Ala Gln Ala Ser Glu Ile Ala Gln Lys Arg Gln 
            580                 585                 590         


Glu Leu Thr Gly Thr Pro Ala Pro Glu Thr Thr Thr Asp Gln Ala Ala 
        595                 600                 605             


Lys Lys Ala Thr Leu Gln Pro Phe Asp Leu Arg Gly Leu Thr Val His 
    610                 615                 620                 


Thr Ala Arg Met Ile Arg Asp Trp Ala Arg Leu Asn Ala Arg Gln Ile 
625                 630                 635                 640 


Ile Gln Leu Ala Glu Glu Asn Gln Val Asp Leu Ile Val Leu Glu Ser 
                645                 650                 655     


Leu Arg Gly Phe Arg Pro Pro Gly Tyr Glu Asn Leu Asp Gln Glu Lys 
            660                 665                 670         


Lys Arg Arg Val Ala Phe Phe Ala His Gly Arg Ile Arg Arg Lys Val 
        675                 680                 685             


Thr Glu Lys Ala Val Glu Arg Gly Met Arg Val Val Thr Val Pro Tyr 
    690                 695                 700                 


Leu Ala Ser Ser Lys Val Cys Ala Glu Cys Arg Lys Lys Gln Lys Asp 
705                 710                 715                 720 


Asn Lys Gln Trp Glu Lys Asn Lys Lys Arg Gly Leu Phe Lys Cys Glu 
                725                 730                 735     


Gly Cys Gly Ser Gln Ala Gln Val Asp Glu Asn Ala Ala Arg Val Leu 
            740                 745                 750         


Gly Arg Val Phe Trp Gly Glu Ile Glu Leu Pro Thr Ala Ile Pro 
        755                 760                 765         


<210> 593
<211> 1202
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 593
Met Ala Val Arg Ser Val Lys Leu Lys Leu Leu Val Pro Arg Asp Gly 
1               5                   10                  15      


Ser Ala Glu Ser Val Arg Lys Arg Lys Ala Leu Trp Ala Thr His Gln 
            20                  25                  30          


Phe Val Asn Asp Ala Ala Ala Ala Tyr Ala Glu Leu Leu Leu Glu Met 
        35                  40                  45              


Arg Gln Glu Asp Val Cys Arg Gly Thr Asp Asp His Gly Lys Asp Val 
    50                  55                  60                  


Ile Glu Pro Ala Ala His Trp Gln Ala Lys Leu Arg Ala Arg Leu Ala 
65                  70                  75                  80  


Ala Lys Gln Leu Pro Pro Val Ala Val Ala Glu Ala Leu Pro Leu Leu 
                85                  90                  95      


Lys Ala Phe Tyr Gly Ser Arg Leu Ile Lys Ser Phe Val Ala Asn Asp 
            100                 105                 110         


Lys Gly Val Ala Gly Thr Gly Asn Ala Thr Asp Leu Asn Thr Trp Leu 
        115                 120                 125             


Ser Gly Leu Val Asp Pro Ala Ser Val Ala Gly Glu Lys Thr Glu Leu 
    130                 135                 140                 


Arg Lys Gln Leu Leu Ala Glu Leu Pro Leu Cys Glu Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Phe Glu Gly Ala Ala Arg Lys Met Leu Ala Lys Ser Asp Ala Arg 
                165                 170                 175     


Glu Ala Leu Leu Glu Gly Pro Gly Thr Gly Val Gly Trp Pro Ala Ala 
            180                 185                 190         


Tyr Asn Ala Asn Pro Thr Asp Ser Val Trp Leu Asp Met Leu His Lys 
        195                 200                 205             


Ala Ala Ala Lys Ala Arg Leu Glu Leu Ala Asp Thr Thr Val Ser Glu 
    210                 215                 220                 


Leu Lys Lys Leu Gly Val Phe Pro Leu Leu Gln Ala Ala Ser Ser Asn 
225                 230                 235                 240 


Arg Val Phe Gly Ser Gly Val Leu Asn Pro Phe Glu Arg Met Ala Ala 
                245                 250                 255     


Ala Gln Ala Ala Ala Ala Leu Leu Pro Trp Glu Thr Lys Arg His Glu 
            260                 265                 270         


Met Arg Lys Arg Arg Asp Lys Phe Ala Asp Gln Leu Asn Gln Trp Asp 
        275                 280                 285             


Thr Glu Phe Gly Ala Ser His Ala Thr Ala Leu Ala Ala Ile Arg Ala 
    290                 295                 300                 


Phe Glu Ala Glu Glu Ser Glu Arg Ala Arg Arg Glu Ser Leu Gly Asn 
305                 310                 315                 320 


Glu Gly Thr Gly Tyr Arg Ile Gly Gly Arg Glu Leu Arg Asp Ala Trp 
                325                 330                 335     


Thr Leu Leu Arg Asp Trp Leu Lys Gly His Ser Thr Ala Thr Ala Ala 
            340                 345                 350         


Ala Arg Glu Asp Lys Val Arg Glu Leu Gln Ala Lys Gln Gly Arg Ser 
        355                 360                 365             


Phe Gly Ser His Arg Leu Leu Ser Trp Leu Ala Lys Pro Ala Gln Gln 
    370                 375                 380                 


Trp Leu Ala Asp His Ser Ala Gly Asp Val Val Thr Arg Ile Ala Val 
385                 390                 395                 400 


Arg Asn Ala Arg Gln Arg Lys Leu Asp Thr Ala Arg Thr Leu Pro Ile 
                405                 410                 415     


Trp Thr Gly Ala Asp Ala Val Lys His Pro Arg Phe Ala Asn Phe Asp 
            420                 425                 430         


Pro Pro Asn Asn Thr Asn Gln Pro Gly Phe Asp Leu Arg Ala Gly Thr 
        435                 440                 445             


Gln Lys Gly Arg Leu Thr Leu Arg Leu Ser Leu Leu Thr Glu Arg Ala 
    450                 455                 460                 


Asp Gly Leu Leu Leu Ala Gln Asp His Asp Phe Gln Leu Val Pro Ser 
465                 470                 475                 480 


Arg Gln Met Ala Glu Ile Val Leu His Lys Asp Gly Lys Glu Arg Ala 
                485                 490                 495     


Leu Ser Trp Gln Ser Gln Asp Gly Ile Gly Arg Gln Val Gly Asp Val 
            500                 505                 510         


Gly Gly Ser Ala Leu Leu Phe Ser Arg Asp His Ala Glu Cys Leu Leu 
        515                 520                 525             


Glu Arg Lys Gln Ile Thr Arg Leu Glu Arg Gly Ala Trp Pro Ala Ala 
    530                 535                 540                 


Leu Pro Val Trp Phe Lys Leu Ser Leu Asp Ile Gly Ala Glu His Lys 
545                 550                 555                 560 


Ala Leu Leu Lys Gln Arg Phe Lys Trp Gly Val Trp Leu Asn Ser Ala 
                565                 570                 575     


Leu Val Thr Arg Asn Ala Lys Asp Ala Lys Gly Val Pro Pro Pro Val 
            580                 585                 590         


Gly Thr Arg Val Leu Ala Val Asp Leu Gly Leu Arg Ser Ala Ala Thr 
        595                 600                 605             


Val Ser Val Trp Gln Val Val Asp Ala Ala Thr Pro Val Val Ala Gly 
    610                 615                 620                 


Lys Trp Arg Val Pro Leu Ser Asp Thr Leu Ser Ala Val His Glu Arg 
625                 630                 635                 640 


Ser Ala Met Leu Ala Leu Pro Gly Glu His Val Asp Ala Gly Val Leu 
                645                 650                 655     


Ala Ala Arg Arg Ala Ala Asn Glu Lys Leu Ala Gly Leu Leu Ala Ala 
            660                 665                 670         


Thr Ser His Leu Ser Thr Val Phe Lys Leu Gly Arg Ala Glu Gln Gly 
        675                 680                 685             


Asp Arg Arg Arg Glu Leu Leu Glu Arg Leu Gly Glu Gly Asp Asp Arg 
    690                 695                 700                 


Arg Ala Arg Ala Ala Val Ala Thr Thr Ala Ala Glu Arg Asp Gly Leu 
705                 710                 715                 720 


Arg Ala Val Leu Gly Ala Thr Gln Asp Ala Trp Ala Gly Ala Val Ala 
                725                 730                 735     


Ala Val Trp Arg Arg Leu Glu Thr Asp Leu Ala Gly Ala Ile Ala Ala 
            740                 745                 750         


Tyr Arg Lys Gln Gln Arg Glu Asp Val Gln Leu Arg Arg Glu Ala Arg 
        755                 760                 765             


His Gly Pro Gly Ala Ser Gln Leu Pro Lys Gln Ala Ala Ala Glu Arg 
    770                 775                 780                 


Leu Leu Gly Gly Lys Ser Ala Trp Gln Ile Glu Tyr Lys Glu Arg Val 
785                 790                 795                 800 


Arg Lys Leu Leu Thr Arg Trp Ile Met Arg Gln Arg Pro Gly Asp Thr 
                805                 810                 815     


Ala Val Arg Arg Leu Ala Arg Lys Asp Leu Gly Lys Tyr Cys Gly Gly 
            820                 825                 830         


Leu Leu Asp His Leu Thr Ala Leu Lys Glu Asp Arg Ala Lys Thr Thr 
        835                 840                 845             


Ala Asp Leu Ile Val Gln Ala Ala Arg Gly Arg Val Arg Ala His Lys 
    850                 855                 860                 


Asp Ala His Gly Arg Gln Gln Asp Arg Glu Leu Trp Leu Ala Lys Tyr 
865                 870                 875                 880 


Ala Pro Cys Asp Leu Ile Val Met Glu Asp Leu Gly Arg Tyr Arg Phe 
                885                 890                 895     


Ala Thr Asp Arg Pro Pro Ser Glu Asn Arg Gln Leu Met Gln Trp Thr 
            900                 905                 910         


His Arg Glu Val Phe Arg Leu Val Gln Met Gln Ala Glu Val Glu Gly 
        915                 920                 925             


Ile Gln Val Leu Glu Thr Gly Ala Glu Phe Ser Ser Lys Phe Asp Ala 
    930                 935                 940                 


Arg Thr Trp Ala Pro Gly Val Arg Cys Glu Pro Ile Thr Lys Leu Trp 
945                 950                 955                 960 


Val Glu Arg Tyr Arg Asn Gly Glu Met Pro Trp Leu Ala Asp Lys Ala 
                965                 970                 975     


Asp Glu Trp Arg Arg Glu Gly Ile Glu Leu Ala Gln Leu Val Pro Gly 
            980                 985                 990         


Gln Leu Leu Pro Thr Gly Ser Gly  Glu Gln Phe Val Ala  Val Ser Ala 
        995                 1000                 1005             


Thr Gly  Gly Leu Arg Val Arg  His Ala Asp Leu Asn  Ala Ala Gln 
    1010                 1015                 1020             


Cys Ile  Ala Leu Arg Ala Leu  Thr Gly His Gly Thr  Ala Phe Arg 
    1025                 1030                 1035             


Leu Thr  Ala Arg Arg Leu Gly  Asp Val Phe Val Ser  Ala Lys Gly 
    1040                 1045                 1050             


Leu Gly  Lys Arg Pro Gln Gly  Ala Leu Trp Arg Glu  Phe Gly Ser 
    1055                 1060                 1065             


Ala Leu  Pro Pro Ala Val Val  Val Leu Arg Pro Ala  Gly Glu Val 
    1070                 1075                 1080             


Arg Tyr  Ala Leu Arg Pro Phe  Ala Ser Ala Arg Asp  Ala Ala Ala 
    1085                 1090                 1095             


Ala Leu  Gly Leu Gln Leu Gly  Ala Leu Arg Asn Val  Asp Ala Thr 
    1100                 1105                 1110             


Asp Ala  Glu Ser Asp Ala Glu  Asp Gly Asp Leu Ala  Glu Leu Leu 
    1115                 1120                 1125             


Ala Gly  Ala Asp Pro Asp Arg  Ala Thr Phe Phe Arg  Asp Pro Ser 
    1130                 1135                 1140             


Gly Asp  Val His Gly Gly Ala  Trp Val Gln Ala Lys  Val Phe Trp 
    1145                 1150                 1155             


Ala Glu  Val Arg Arg His Val  Arg Leu Gly Leu Gln  Ala Gln Gly 
    1160                 1165                 1170             


Leu Leu  Pro Ala Ala Ala Arg  Ser Ser Glu Pro Arg  Gln Met Gln 
    1175                 1180                 1185             


Leu Pro  Leu Ala Gly Ala Leu  Pro Gly Asp Asp Ile  Pro Leu 
    1190                 1195                 1200         


<210> 594
<211> 1375
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 594
Met Asn Arg Ile Tyr Gln Gly Arg Val Ser Lys Ile Glu Ile Lys Asp 
1               5                   10                  15      


Ser Glu Gly Asn Phe Arg Asn Val Pro Val Gly Ser Pro Asp Thr Cys 
            20                  25                  30          


Pro Leu Trp Arg His His Arg Ile Phe Gln Asp Ala Val Asn Tyr Tyr 
        35                  40                  45              


Leu Val Ala Leu Gly Ala Leu Ala Gly Thr Gly Ser Glu Asn Ala Phe 
    50                  55                  60                  


Val Gly Leu Gly Ser Lys Asp Arg Val Ile His Asp Leu Tyr Ser Arg 
65                  70                  75                  80  


Leu Phe Asp Ser Trp Glu Arg Phe Pro Arg Asp Met His Gly Ala Ser 
                85                  90                  95      


Ser Leu Arg Asp Ser Leu Arg Arg Thr Leu Pro Gly Leu Ser Glu Arg 
            100                 105                 110         


Ala Ser Leu Gln Asp Ala Phe Asp Ala Ile Leu Ser Gly Asn Glu Ala 
        115                 120                 125             


Asn Ala Arg Glu Arg Val Leu Ser Leu Leu Ser Leu Ile Gln Asp Leu 
    130                 135                 140                 


Gly Gly Asp Ile Gln Lys Gly Ser Lys Arg Tyr Phe Pro Phe Phe Cys 
145                 150                 155                 160 


Glu Pro Ala Thr Lys Ala Thr Phe Pro Arg Ala Arg Val Gly Leu Leu 
                165                 170                 175     


Lys Val Glu Gly Lys Asp Phe Val Pro Arg Leu Leu Trp Ser Ser Asp 
            180                 185                 190         


Leu Glu Ile Ala Pro Asp Gln Val Val Glu Gln Leu Lys Phe Glu Tyr 
        195                 200                 205             


Phe Ala Asn Pro Asn Glu Ser Val Gln Pro Ile Glu Gly Asn Glu Ala 
    210                 215                 220                 


Arg Val Arg Leu Ile Glu Ala Leu Asp Asn Pro Gln Leu Gly Ile Glu 
225                 230                 235                 240 


Leu Pro Ile Glu Ile Leu Ser Asp Leu Arg Lys Arg Val His Leu Ile 
                245                 250                 255     


Glu Thr Asp Ile Arg Ile Pro Arg Tyr Phe Phe Gly Gly Ala Gly Ala 
            260                 265                 270         


Glu Leu Arg Lys Phe Arg Leu Asp Leu Phe Leu Ile Ala Ala Tyr Val 
        275                 280                 285             


Thr Pro Asp Pro Ser Ile Leu Arg Ala Leu Arg Asn Ser Phe Lys Glu 
    290                 295                 300                 


Pro Ser Ala Ser Lys Ser Ser Lys Lys Lys Asp Glu Thr Glu Glu Val 
305                 310                 315                 320 


Glu Asn Leu Leu Arg Ser Leu Gly Asp Asp Pro Leu Ile Leu Ala Arg 
                325                 330                 335     


Gly Glu Arg Gly Phe Val Phe Pro Ser Phe Thr Ser Leu Pro Thr Trp 
            340                 345                 350         


Val Gly Ala Asn Ala Gln Lys Pro Ile Trp Arg Asp Phe Asp Ile Ala 
        355                 360                 365             


Ala Phe Ala Glu Ala Leu Lys Ser Leu Asn Gln Phe Thr Ala Lys Thr 
    370                 375                 380                 


Glu Glu Arg Glu Glu Lys Leu Lys Lys Ala Glu Glu Thr Leu His Tyr 
385                 390                 395                 400 


Met Leu Gly Ile Ser Asp Ala Ile Pro Arg Ser Ser Asp Ser Glu Thr 
                405                 410                 415     


Glu Glu Gln Ala Pro Ser Arg Pro Gly Lys Asp Pro Arg Trp Pro Leu 
            420                 425                 430         


Val Ala Gln Leu Glu Lys Glu Leu Gly Glu Asn Leu Ser Glu Gly Thr 
        435                 440                 445             


Trp Gln Leu Ser Arg Ser Ala Met Arg Gly Leu Arg Asp Ile Ile Gly 
    450                 455                 460                 


Leu Trp Arg Lys His Pro Gly Ala Ser Val Val Thr Leu Gln Lys Asp 
465                 470                 475                 480 


Val Lys Thr Tyr Gln Ala Asp Glu Lys His Lys Arg Glu Ile Gly Ser 
                485                 490                 495     


Val Gln Leu Phe Leu Leu Leu Cys Glu Glu Arg Tyr His Ala Leu Trp 
            500                 505                 510         


Gln Thr Glu Thr Asp Asp Glu Arg Gly Asp Glu Ser Glu Glu Asn Asp 
        515                 520                 525             


Asp Pro Ala Arg Ile Leu Ser Asp Ala Ile Glu Val His Gln Ile Arg 
    530                 535                 540                 


Arg Glu Val Glu Arg Phe Arg Glu Pro Ile Arg Leu Thr Pro Ala Glu 
545                 550                 555                 560 


Pro Val Phe Ser Arg Arg Leu Phe Met Phe Ser Asp Leu Thr Asp Lys 
                565                 570                 575     


Leu Ala Lys Val Lys Phe Gly Glu Thr Thr Glu Glu Asn Ser Glu Val 
            580                 585                 590         


Lys Ser Gln Phe Val Glu Ala Ala Ile Ala Leu Lys Glu Gly Glu Asn 
        595                 600                 605             


Leu Lys Glu Ala Arg Val Arg Ile Thr Phe Ser Ala Pro Arg Leu His 
    610                 615                 620                 


Arg Asp Glu Leu Leu Gly Gly Ala Glu Ser Arg Trp Leu Gln Pro Ile 
625                 630                 635                 640 


Thr Ala Ala Leu Gly Phe Ser Asn Pro Ala Pro Ser Val Lys Phe Asp 
                645                 650                 655     


Ser Ala Val Ala Leu Met Pro Asp His Met Asp Asp Gly Arg Ile Arg 
            660                 665                 670         


His Leu Leu Asn Phe Pro Val Asn Phe Asp Ser Ala Trp Leu His Gln 
        675                 680                 685             


Ser Ile Gly Lys Ala Asp Leu Trp Lys Ser Gln Phe Asn Gly Thr Lys 
    690                 695                 700                 


Asp Lys Asn Leu His Leu His Trp Ala Gly Thr Ala Arg Asp Thr Thr 
705                 710                 715                 720 


Arg Lys Asn Thr Trp Trp Glu Asn Arg Thr Ile Ile Glu Asn Gly Phe 
                725                 730                 735     


Thr Val Leu Ser Asn Asp Leu Gly Gln Arg Ser Ala Gly Ala Trp Ala 
            740                 745                 750         


Leu Leu Lys Val Thr Cys Ser Arg Pro Asp Thr Lys His Pro Val Arg 
        755                 760                 765             


Ser Ile Gly His Asp Gly Thr Arg Glu Trp Phe Ala Thr Val Leu Ala 
    770                 775                 780                 


Thr Gly Ile His Arg Leu Pro Gly Glu Asp Gln Arg Ile Leu Lys Asn 
785                 790                 795                 800 


Gly Lys Trp Ala Thr Glu Gln Ser Gly Lys Lys Gly Arg Asn Ala Thr 
                805                 810                 815     


Phe Ser Glu Tyr Glu Ala Ala Cys Val Leu Ala Lys Asn Leu Gly Cys 
            820                 825                 830         


Glu Ser Val Glu Asn Trp Leu Gly Met Ser Gly Glu Lys Ser Tyr Pro 
        835                 840                 845             


Ala Leu Asn Asp Gln Leu Val Lys Ile Ala Asn Arg Arg Ile Thr Arg 
    850                 855                 860                 


Leu Gly Thr Tyr His Arg Trp Ser Cys Phe Ser Pro Glu Lys Phe Glu 
865                 870                 875                 880 


Asp Pro Ala Arg Arg Ala Asn Val Ile Gly Gly Gln Leu Ala Glu Leu 
                885                 890                 895     


Ser Ala Tyr Gln Asp Glu Asn Val Thr Val Ser Ala Asp Ile Leu Lys 
            900                 905                 910         


Ser Gly Asp Phe Glu Gly Phe Arg His Arg Ala Gly Ala Ala Phe Glu 
        915                 920                 925             


Ala Leu Arg Thr Glu Leu Glu Val His Leu Val Asn Leu Ala Asn Leu 
    930                 935                 940                 


Thr Ala Pro Leu Arg Gln Lys Val Trp Ser Trp Gln Lys Arg Pro Asp 
945                 950                 955                 960 


Ser Ser Gly Tyr Gly Asp Leu Leu Met Val Asp Leu Asp Asp Cys His 
                965                 970                 975     


Pro Lys Ile Arg Gly Gln Arg Gly Leu Ser Met Ala Arg Leu Glu Gln 
            980                 985                 990         


Leu Glu Gly Leu Arg Arg Leu Phe  Leu Arg Tyr Asn Arg  Ser Leu Asp 
        995                 1000                 1005             


Arg Ser  Pro Gly Ile Pro Ala  Lys Phe Gly Arg Glu  Asp Val Gly 
    1010                 1015                 1020             


Arg Thr  Ser Gly Glu Pro Cys  Gln Ala Leu Leu Val  Lys Ile Asp 
    1025                 1030                 1035             


Arg Met  Lys Glu Gln Arg Val  Asn Gln Thr Ala His  Leu Ile Leu 
    1040                 1045                 1050             


Ala Gln  Ala Leu Gly Val Arg  Leu Cys Pro His Arg  Ile Glu Glu 
    1055                 1060                 1065             


Asn Glu  Arg Lys Ser Arg Asp  Leu His Gly Glu Tyr  Glu Lys Ile 
    1070                 1075                 1080             


Pro Gly  Arg Glu Pro Val Asp  Phe Ile Val Ile Glu  Asp Leu Ser 
    1085                 1090                 1095             


Arg Tyr  Leu Ser Ser Gln Gly  Arg Ala Pro Ser Glu  Asn Ser Arg 
    1100                 1105                 1110             


Leu Met  Lys Trp Ala His Arg  Ala Val Arg Asp Lys  Leu Lys Met 
    1115                 1120                 1125             


Leu Ala  Glu Glu Pro Phe Gly  Ile Pro Val Val Glu  Thr Val Pro 
    1130                 1135                 1140             


Ala Tyr  Ser Ser Arg Phe His  Ala Leu Asn Gly Gln  Ala Gly Ser 
    1145                 1150                 1155             


Arg Leu  His Glu Leu His Glu  Leu Glu Ala Tyr Gln  Gln Gln Ser 
    1160                 1165                 1170             


Leu Ile  Asn Leu Ala Ala Lys  Thr Asp Phe Gln Asn  Arg Asp Arg 
    1175                 1180                 1185             


Ser Lys  Ala Ala Gly Glu Leu  Phe Glu Gln Phe Gln  Ala Leu Ala 
    1190                 1195                 1200             


Lys Leu  Asn Glu Arg Arg Arg  Ala Glu Gly Lys Lys  Val Pro Arg 
    1205                 1210                 1215             


Thr Leu  Tyr Tyr Pro Lys Ser  Gly Gly Pro Leu Phe  Leu Ala Ser 
    1220                 1225                 1230             


Arg Asp  Gly Asp Thr Ile His  Ala Asp Val Asn Ala  Ala Ile Asn 
    1235                 1240                 1245             


Leu Gly  Leu Arg Ala Ile Ala  Ala Pro Ala Cys Ile  Asp Ile His 
    1250                 1255                 1260             


Arg Arg  Leu Arg Ala Thr Lys  Glu Lys Glu Val Tyr  Arg Pro Arg 
    1265                 1270                 1275             


Val Gly  Asn Ala Arg Glu Lys  Ser Ala Phe Ser Lys  Asp Asp Ile 
    1280                 1285                 1290             


Ile Gln  Pro Ser Gly Ala Pro  Ser Lys Lys Phe Ala  Ser Ser Ser 
    1295                 1300                 1305             


Ser Pro  Asn Phe Phe Tyr Glu  Pro Glu Asp Leu Lys  Gln Ala Asn 
    1310                 1315                 1320             


Gly Glu  Pro Leu Phe Asp Arg  Ala Met Phe Gly Glu  Tyr Ser Leu 
    1325                 1330                 1335             


Val Ser  Gly Val Ser Leu Trp  Ser Met Val Asn Asn  Ala Ile Tyr 
    1340                 1345                 1350             


Ile Arg  Cys Val Glu Leu Asn  Arg Thr Arg Leu His  Gly Lys Asp 
    1355                 1360                 1365             


Pro Asp  Asp Gln Ile Pro Met  
    1370                 1375 


<210> 595
<211> 1496
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 595
Met Ala Asp Asp Leu Ser Thr Gln Arg Ala Tyr Thr Leu Arg Leu Gln 
1               5                   10                  15      


Gly Thr Asp Pro Glu Asp Gln Ser Trp Arg Asp Ala Leu Trp Met Thr 
            20                  25                  30          


His Glu Ala Val Asn Ala Gly Gly Arg Ala Phe Gly Asp Trp Leu Leu 
        35                  40                  45              


Thr Leu Arg Gly Gly Ile Ala His Glu Leu Ala Asp Thr Pro Val Lys 
    50                  55                  60                  


Gly Lys Lys Asp Ile Thr Asp Glu Leu Arg Lys Lys Arg Arg Ile Leu 
65                  70                  75                  80  


Leu Ala Leu Ser Trp Leu Ser Val Glu Ser Arg Arg Gly Ala Pro Asp 
                85                  90                  95      


Lys Phe Ile Val Ala Gly Gly Glu Glu Pro Ala Gly Ser Arg Asn Glu 
            100                 105                 110         


Lys Val Leu Gln Ala Leu Lys Glu Ile Leu Lys Arg Arg Gly Leu Ser 
        115                 120                 125             


Ala Glu Glu Ser Glu Ser Trp Met Ser Asp Cys Arg Ala Ser Leu Ser 
    130                 135                 140                 


Ala Ala Ile Arg Asp Asp Ala Val Trp Val Asn Arg Ser Ala Ala Phe 
145                 150                 155                 160 


Asp Asp Ala Gln Val Arg Ile Gly Ala Ser Leu Thr Arg Glu Asp Ile 
                165                 170                 175     


Trp Asp Met Leu Asp Pro Phe Phe Gly Ser Arg Glu Ala Tyr Leu Thr 
            180                 185                 190         


Pro Ala Lys Lys Lys Lys Glu Asp Glu Asp Ser Ser Glu Gly Thr Gly 
        195                 200                 205             


Glu Glu Lys Ala Lys Asp Leu Val Gln Lys Ala Gly Gln Trp Leu Ser 
    210                 215                 220                 


Ser Arg Phe Gly Thr Gly Lys Gly Ala Asn Phe Asp Ala Met Ala Glu 
225                 230                 235                 240 


Val Tyr Ser Lys Ile Ser Glu Trp Ala Gly Thr Ala Gln Glu Gly Val 
                245                 250                 255     


Ser Gly Lys Glu Gly Ile Lys Asn Leu Ala Asp Ala Leu Ala Ala Phe 
            260                 265                 270         


Ser Pro Val Ser Gln Asn Leu Glu Gly Val Leu Lys Leu Ile Ser Gly 
        275                 280                 285             


Pro Gly Tyr Lys Ser Ala Thr Arg Asn Leu Leu Gly Glu Leu Asp Ser 
    290                 295                 300                 


Leu Pro Val Val Ser Arg Asp His Leu Ser Ala Leu His Glu Lys Ala 
305                 310                 315                 320 


Ala Glu Asp Thr Val Lys Cys Lys Glu Ser Thr Gly Thr Lys Gly Arg 
                325                 330                 335     


Arg Pro Tyr Ala Asp Ala Ile Leu Asn Asp Val Glu Lys Arg Cys Gly 
            340                 345                 350         


Phe Thr Tyr Leu Thr Asp Ser Asp Asn Arg Ser Val Ser Ile Leu Asp 
        355                 360                 365             


Thr Ser Glu Phe Pro Ser Asp Tyr Lys Trp Gly Thr Ala Arg His Ser 
    370                 375                 380                 


Glu Phe Ala Val Ile Leu Asp His Ala Ala Arg Arg Ile Ser Val Ala 
385                 390                 395                 400 


His Ser Trp Ile Lys Leu Ala Glu Ala Glu Arg Asp Arg Cys Glu Glu 
                405                 410                 415     


Asp Ala Ala Lys Val Tyr Asp Leu Pro Asp Lys Val Lys Glu Trp Leu 
            420                 425                 430         


Asp Thr Phe Cys Ser Asn Arg Ser Asp Ile Ser Gly Ala Gln Gly Glu 
        435                 440                 445             


Gly Tyr Arg Ile Arg Arg Lys Ala Ile Glu Gly Trp Lys Glu Val Val 
    450                 455                 460                 


Ala Ser Trp Gly Arg Ser Ser Cys Ile Thr Ala Glu Asp Arg Val Ala 
465                 470                 475                 480 


Ala Ala Arg Ala Leu Gln Asp Asp Pro Glu Ile Asp Lys Phe Gly Asp 
                485                 490                 495     


Ile Gln Leu Phe Glu Ile Leu Ala Gln Asp Glu Ala Leu Cys Val Trp 
            500                 505                 510         


His Lys Asp Gly Asp Val Ala Lys Ser Pro Asp Ala Gln Met Leu Ile 
        515                 520                 525             


Asp Tyr Val Leu Ala Ser Asp Ala Glu Ser Lys Lys Arg Arg Phe Lys 
    530                 535                 540                 


Val Pro Ala Tyr Arg His Pro Asp Ala Leu Leu His Pro Ile Phe Cys 
545                 550                 555                 560 


Asp Phe Gly Asn Ser Arg Trp Asp Ile Thr Tyr Asp Ile His Gly Ala 
                565                 570                 575     


Arg Gly Lys Lys Lys Ala Lys Arg Gly Ser Lys Lys Glu Glu Ala Met 
            580                 585                 590         


Pro Arg Gly Val Ala Met Lys Leu Trp Thr Gly Ser Asp Val Leu Ser 
        595                 600                 605             


Val Ser Leu Arg Trp Gln Ser Lys Lys Leu Ala Ala Asp Leu Ala Leu 
    610                 615                 620                 


Asp Gln Glu Ala Glu Glu Val Thr Asp Thr Ala Ala Val Ser Arg Ala 
625                 630                 635                 640 


Asp Arg Leu Gly Arg Ala Ala Ala Gly Ile Asp Arg Gly Ala Gly Val 
                645                 650                 655     


Thr Ile Ala Gly Leu Phe Glu Glu Ala His Trp Asn Gly Arg Leu Gln 
            660                 665                 670         


Ala Pro Arg Gln Gln Leu Glu Ala Ile Ala Ala Val Arg Asp Asn Gln 
        675                 680                 685             


Lys Leu Ser Ser Glu Glu Arg Glu Arg Arg Ile Ala Phe Met Lys Asp 
    690                 695                 700                 


Arg Ile Arg Trp Leu Val Thr Phe Ser Ala Lys Leu Arg Pro Gln Gly 
705                 710                 715                 720 


Pro Trp His Ser Tyr Ala Pro Thr Gln Gly Leu Gln Ser Asp Pro Lys 
                725                 730                 735     


Tyr Trp Pro His Ser Glu Ile Asn Lys Lys Arg Lys Gly Gln Ala Lys 
            740                 745                 750         


Leu Ile Leu Ser Arg Leu Pro Gly Leu Arg Ile Leu Ser Val Asp Leu 
        755                 760                 765             


Gly His Arg Phe Ala Ala Ala Cys Ala Val Trp Glu Thr Met Ser Ser 
    770                 775                 780                 


Glu Ala Ile Gln Glu Ala Cys Arg Leu Ala Asn His Gln Leu Pro Ala 
785                 790                 795                 800 


Pro Ala Asp Leu Tyr Leu His Leu Lys Arg Thr Val Gln Lys Asn Leu 
                805                 810                 815     


Ile Asp Gly Glu Lys Thr Val Glu Glu Ser Thr Val Tyr Arg Arg Ile 
            820                 825                 830         


Gly Ala Asp Arg Leu Pro Asp Gly Thr Ala His Pro Ala Pro Trp Ala 
        835                 840                 845             


Arg Leu Asp Arg Gln Phe Leu Ile Lys Leu Gln Gly Glu Glu Lys Val 
    850                 855                 860                 


Arg Glu Ala Ser Asn Glu Glu Val Trp Gln Val His Leu Met Glu Ser 
865                 870                 875                 880 


Ala Leu Gly Leu Ser Phe Pro Leu Ile Asp Arg Leu Val Tyr Ala Gly 
                885                 890                 895     


Trp Gly Gly Thr Glu Lys Gln Ala Ala Arg Leu Glu Ala Leu Arg Glu 
            900                 905                 910         


Lys Gly Trp Lys Pro Thr Gly Thr Pro Ala Asp Gln Asp Glu Glu Gly 
        915                 920                 925             


Gly Gly Tyr Lys Pro Ser Leu Ala Val Asp Glu Leu Met Phe Ser Ala 
    930                 935                 940                 


Val Arg Thr Leu Arg Leu Ala Leu Lys Tyr His Gly Asp Arg Ala Arg 
945                 950                 955                 960 


Ile Ala Phe Ala Leu Thr Ala Asp Tyr Lys Pro Met Pro Gly Asp Thr 
                965                 970                 975     


Arg Tyr Tyr Phe Ser Glu Ala Lys Asp Arg Ser Ser Gly Ala Asp Ala 
            980                 985                 990         


Ala Glu Arg Glu Ala Lys His Lys  Asp Tyr Leu Leu Asp  Met Leu Leu 
        995                 1000                 1005             


Leu Trp  His Asp Leu Ala Phe  Ser Arg Lys Trp Arg  Asp Glu Glu 
    1010                 1015                 1020             


Ala Lys  Glu Leu Trp Asn Leu  His Ile Ala Ala Leu  Pro Gly Tyr 
    1025                 1030                 1035             


Gln Ala  Pro Ala Ala Pro Ile  Gln Glu Glu Ala Gly  Gln Gly Arg 
    1040                 1045                 1050             


Lys Lys  Ala Arg Glu Glu Ala  Arg Ala Lys Met Thr  Pro Ala Ala 
    1055                 1060                 1065             


Glu Ala  Leu Leu Ala Asp Gly  Thr Leu Arg Glu Lys  Leu His Gly 
    1070                 1075                 1080             


Leu Trp  Lys Glu Arg Trp Glu  Lys Asp Asp Ala Gln  Trp Lys Lys 
    1085                 1090                 1095             


His Leu  Arg Trp Met Lys Asp  Gly Ile Leu Pro Arg  Gly Gly Arg 
    1100                 1105                 1110             


Ala Ala  Thr Pro Ser Ile Arg  Tyr Val Gly Gly Leu  Ser Leu Thr 
    1115                 1120                 1125             


Arg Leu  Ala Thr Leu Thr Glu  Phe Arg Arg Lys Val  Gln Val Gly 
    1130                 1135                 1140             


Phe Tyr  Thr Arg Leu Phe Pro  Ser Gly Glu Lys Arg  Glu Ile Lys 
    1145                 1150                 1155             


Glu Ala  Phe Gly Gln Thr Ala  Leu Asp Ala Leu Glu  Arg Leu Arg 
    1160                 1165                 1170             


Glu Gln  Arg Val Lys Gln Leu  Ala Ser Arg Ile Ala  Glu Ala Ala 
    1175                 1180                 1185             


Leu Gly  Ala Gly Arg Val Ser  Arg Thr Ala Leu Lys  Gln Asp Pro 
    1190                 1195                 1200             


Lys Arg  Pro Glu Ala Arg Val  Asp Ala Ala Cys His  Ala Val Ile 
    1205                 1210                 1215             


Ile Glu  Asn Leu Glu His Tyr  Arg Pro Glu Glu Thr  Arg Thr Arg 
    1220                 1225                 1230             


Arg Glu  Asn Arg Gly Leu Met  Asn Trp Ala Ser Ser  Lys Val Lys 
    1235                 1240                 1245             


Lys Tyr  Leu Ser Glu Ala Cys  Gln Leu His Gly Leu  Phe Leu Arg 
    1250                 1255                 1260             


Glu Val  Pro Ala Gly Tyr Thr  Ser Arg Gln Asp Ser  Arg Thr Gly 
    1265                 1270                 1275             


Ala Pro  Gly Met Arg Cys Gln  Asp Val Thr Val Lys  Thr Phe Leu 
    1280                 1285                 1290             


Asn Ser  Pro Phe Trp Gln Lys  Gln Cys Val Gln Ala  Gln Lys Asn 
    1295                 1300                 1305             


Lys Ser  Thr Ala Arg Asp Arg  Phe Leu Cys Ala Leu  Lys Glu Ala 
    1310                 1315                 1320             


Val Ala  Gln Gly Gly Met Glu  Glu Glu Lys Lys Met  Gly Pro Ile 
    1325                 1330                 1335             


Arg Val  Pro Val Pro Gly Gly  Glu Val Phe Val Ser  Ala Asp Ala 
    1340                 1345                 1350             


Ala Ser  Pro Ala Ala Lys Gly  Leu Gln Ala Asp Leu  Asn Ala Ala 
    1355                 1360                 1365             


Ala Asn  Ile Gly Leu Arg Ala  Leu Leu Asp Pro Asp  Trp Pro Gly 
    1370                 1375                 1380             


Lys Trp  Trp Tyr Val Pro Cys  Asp Arg Lys Thr Ala  Tyr Pro Ala 
    1385                 1390                 1395             


Lys Glu  Lys Val Glu Gly Ser  Ala Ala Val Asp Val  Lys Gln Ala 
    1400                 1405                 1410             


Leu Pro  Phe Val Leu Pro Glu  Glu Lys Glu Asn Lys  Gly Lys Thr 
    1415                 1420                 1425             


Lys Gly  Gly Lys Lys Gly Lys  Gly Glu Val Met Asn  Leu Trp Arg 
    1430                 1435                 1440             


Asp Val  Ser Ala Glu Pro Leu  Met Thr Gly Gln Trp  Leu Asp Tyr 
    1445                 1450                 1455             


Thr Ala  Tyr Arg Lys Glu Val  Glu Asn Arg Val Ile  Gln Val Leu 
    1460                 1465                 1470             


Thr Ala  Gln Leu Lys Ala Arg  Asn Pro Leu Arg Phe  Gly Asn Leu 
    1475                 1480                 1485             


Gly Asp  Glu Glu Glu Ile Pro  Tyr 
    1490                 1495     


<210> 596
<211> 1108
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 596
Met Ala Ile Arg Ser Ile Lys Leu Lys Leu Lys Thr His Thr Gly Pro 
1               5                   10                  15      


Glu Ala Gln Asn Leu Arg Lys Gly Ile Trp Arg Thr His Arg Leu Leu 
            20                  25                  30          


Asn Glu Gly Val Ala Tyr Tyr Met Lys Met Leu Leu Leu Phe Arg Gln 
        35                  40                  45              


Glu Ser Thr Gly Glu Arg Pro Lys Glu Glu Leu Gln Glu Glu Leu Ile 
    50                  55                  60                  


Cys His Ile Arg Glu Gln Gln Gln Arg Asn Gln Ala Asp Lys Asn Thr 
65                  70                  75                  80  


Gln Ala Leu Pro Leu Asp Lys Ala Leu Glu Ala Leu Arg Gln Leu Tyr 
                85                  90                  95      


Glu Leu Leu Val Pro Ser Ser Val Gly Gln Ser Gly Asp Ala Gln Ile 
            100                 105                 110         


Ile Ser Arg Lys Phe Leu Ser Pro Leu Val Asp Pro Asn Ser Glu Gly 
        115                 120                 125             


Gly Lys Gly Thr Ser Lys Ala Gly Ala Lys Pro Thr Trp Gln Lys Lys 
    130                 135                 140                 


Lys Glu Ala Asn Asp Pro Thr Trp Glu Gln Asp Tyr Glu Lys Trp Lys 
145                 150                 155                 160 


Lys Arg Arg Glu Glu Asp Pro Thr Ala Ser Val Ile Thr Thr Leu Glu 
                165                 170                 175     


Glu Tyr Gly Ile Arg Pro Ile Phe Pro Leu Tyr Thr Asn Thr Val Thr 
            180                 185                 190         


Asp Ile Ala Trp Leu Pro Leu Gln Ser Asn Gln Phe Val Arg Thr Trp 
        195                 200                 205             


Asp Arg Asp Met Leu Gln Gln Ala Ile Glu Arg Leu Leu Ser Trp Glu 
    210                 215                 220                 


Ser Trp Asn Lys Arg Val Gln Glu Glu Tyr Ala Lys Leu Lys Glu Lys 
225                 230                 235                 240 


Met Ala Gln Leu Asn Glu Gln Leu Glu Gly Gly Gln Glu Trp Ile Ser 
                245                 250                 255     


Leu Leu Glu Gln Tyr Glu Glu Asn Arg Glu Arg Glu Leu Arg Glu Asn 
            260                 265                 270         


Met Thr Ala Ala Asn Asp Lys Tyr Arg Ile Thr Lys Arg Gln Met Lys 
        275                 280                 285             


Gly Trp Asn Glu Leu Tyr Glu Leu Trp Ser Thr Phe Pro Ala Ser Ala 
    290                 295                 300                 


Ser His Glu Gln Tyr Lys Glu Ala Leu Lys Arg Val Gln Gln Arg Leu 
305                 310                 315                 320 


Arg Gly Arg Phe Gly Asp Ala His Phe Phe Gln Tyr Leu Met Glu Glu 
                325                 330                 335     


Lys Asn Arg Leu Ile Trp Lys Gly Asn Pro Gln Arg Ile His Tyr Phe 
            340                 345                 350         


Val Ala Arg Asn Glu Leu Thr Lys Arg Leu Glu Glu Ala Lys Gln Ser 
        355                 360                 365             


Ala Thr Met Thr Leu Pro Asn Ala Arg Lys His Pro Leu Trp Val Arg 
    370                 375                 380                 


Phe Asp Ala Arg Gly Gly Asn Leu Gln Asp Tyr Tyr Leu Thr Ala Glu 
385                 390                 395                 400 


Ala Asp Lys Pro Arg Ser Arg Arg Phe Val Thr Phe Ser Gln Leu Ile 
                405                 410                 415     


Trp Pro Ser Glu Ser Gly Trp Met Glu Lys Lys Asp Val Glu Val Glu 
            420                 425                 430         


Leu Ala Leu Ser Arg Gln Phe Tyr Gln Gln Val Lys Leu Leu Lys Asn 
        435                 440                 445             


Asp Lys Gly Lys Gln Lys Ile Glu Phe Lys Asp Lys Gly Ser Gly Ser 
    450                 455                 460                 


Thr Phe Asn Gly His Leu Gly Gly Ala Lys Leu Gln Leu Glu Arg Gly 
465                 470                 475                 480 


Asp Leu Glu Lys Glu Glu Lys Asn Phe Glu Asp Gly Glu Ile Gly Ser 
                485                 490                 495     


Val Tyr Leu Asn Val Val Ile Asp Phe Glu Pro Leu Gln Glu Val Lys 
            500                 505                 510         


Asn Gly Arg Val Gln Ala Pro Tyr Gly Gln Val Leu Gln Leu Ile Arg 
        515                 520                 525             


Arg Pro Asn Glu Phe Pro Lys Val Thr Thr Tyr Lys Ser Glu Gln Leu 
    530                 535                 540                 


Val Glu Trp Ile Lys Ala Ser Pro Gln His Ser Ala Gly Val Glu Ser 
545                 550                 555                 560 


Leu Ala Ser Gly Phe Arg Val Met Ser Ile Asp Leu Gly Leu Arg Ala 
                565                 570                 575     


Ala Ala Ala Thr Ser Ile Phe Ser Val Glu Glu Ser Ser Asp Lys Asn 
            580                 585                 590         


Ala Ala Asp Phe Ser Tyr Trp Ile Glu Gly Thr Pro Leu Val Ala Val 
        595                 600                 605             


His Gln Arg Ser Tyr Met Leu Arg Leu Pro Gly Glu Gln Val Glu Lys 
    610                 615                 620                 


Gln Val Met Glu Lys Arg Asp Glu Arg Phe Gln Leu His Gln Arg Val 
625                 630                 635                 640 


Lys Phe Gln Ile Arg Val Leu Ala Gln Ile Met Arg Met Ala Asn Lys 
                645                 650                 655     


Gln Tyr Gly Asp Arg Trp Asp Glu Leu Asp Ser Leu Lys Gln Ala Val 
            660                 665                 670         


Glu Gln Lys Lys Ser Pro Leu Asp Gln Thr Asp Arg Thr Phe Trp Glu 
        675                 680                 685             


Gly Ile Val Cys Asp Leu Thr Lys Val Leu Pro Arg Asn Glu Ala Asp 
    690                 695                 700                 


Trp Glu Gln Ala Val Val Gln Ile His Arg Lys Ala Glu Glu Tyr Val 
705                 710                 715                 720 


Gly Lys Ala Val Gln Ala Trp Arg Lys Arg Phe Ala Ala Asp Glu Arg 
                725                 730                 735     


Lys Gly Ile Ala Gly Leu Ser Met Trp Asn Ile Glu Glu Leu Glu Gly 
            740                 745                 750         


Leu Arg Lys Leu Leu Ile Ser Trp Ser Arg Arg Thr Arg Asn Pro Gln 
        755                 760                 765             


Glu Val Asn Arg Phe Glu Arg Gly His Thr Ser His Gln Arg Leu Leu 
    770                 775                 780                 


Thr His Ile Gln Asn Val Lys Glu Asp Arg Leu Lys Gln Leu Ser His 
785                 790                 795                 800 


Ala Ile Val Met Thr Ala Leu Gly Tyr Val Tyr Asp Glu Arg Lys Gln 
                805                 810                 815     


Glu Trp Cys Ala Glu Tyr Pro Ala Cys Gln Val Ile Leu Phe Glu Asn 
            820                 825                 830         


Leu Ser Gln Tyr Arg Ser Asn Leu Asp Arg Ser Thr Lys Glu Asn Ser 
        835                 840                 845             


Thr Leu Met Lys Trp Ala His Arg Ser Ile Pro Lys Tyr Val His Met 
    850                 855                 860                 


Gln Ala Glu Pro Tyr Gly Ile Gln Ile Gly Asp Val Arg Ala Glu Tyr 
865                 870                 875                 880 


Ser Ser Arg Phe Tyr Ala Lys Thr Gly Thr Pro Gly Ile Arg Cys Lys 
                885                 890                 895     


Lys Val Arg Gly Gln Asp Leu Gln Gly Arg Arg Phe Glu Asn Leu Gln 
            900                 905                 910         


Lys Arg Leu Val Asn Glu Gln Phe Leu Thr Glu Glu Gln Val Lys Gln 
        915                 920                 925             


Leu Arg Pro Gly Asp Ile Val Pro Asp Asp Ser Gly Glu Leu Phe Met 
    930                 935                 940                 


Thr Leu Thr Asp Gly Ser Gly Ser Lys Glu Val Val Phe Leu Gln Ala 
945                 950                 955                 960 


Asp Ile Asn Ala Ala His Asn Leu Gln Lys Arg Phe Trp Gln Arg Tyr 
                965                 970                 975     


Asn Glu Leu Phe Lys Val Ser Cys Arg Val Ile Val Arg Asp Glu Glu 
            980                 985                 990         


Glu Tyr Leu Val Pro Lys Thr Lys  Ser Val Gln Ala Lys  Leu Gly Lys 
        995                 1000                 1005             


Gly Leu  Phe Val Lys Lys Ser  Asp Thr Ala Trp Lys  Asp Val Tyr 
    1010                 1015                 1020             


Val Trp  Asp Ser Gln Ala Lys  Leu Lys Gly Lys Thr  Thr Phe Thr 
    1025                 1030                 1035             


Glu Glu  Ser Glu Ser Pro Glu  Gln Leu Glu Asp Phe  Gln Glu Ile 
    1040                 1045                 1050             


Ile Glu  Glu Ala Glu Glu Ala  Lys Gly Thr Tyr Arg  Thr Leu Phe 
    1055                 1060                 1065             


Arg Asp  Pro Ser Gly Val Phe  Phe Pro Glu Ser Val  Trp Tyr Pro 
    1070                 1075                 1080             


Gln Lys  Asp Phe Trp Gly Glu  Val Lys Arg Lys Leu  Tyr Gly Lys 
    1085                 1090                 1095             


Leu Arg  Glu Arg Phe Leu Thr  Lys Ala Arg 
    1100                 1105             


<210> 597
<211> 1098
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 597
Met Pro Val Arg Ser Ile Asn Leu Lys Ile Val Ile Ser Arg Asn Thr 
1               5                   10                  15      


Gln Gly Glu Lys Ser Arg Gln Ser Ile Trp Thr Thr His Ala Ala Val 
            20                  25                  30          


Asn Asp Ala Val Arg Tyr Tyr Glu Glu Gln Leu Leu Ile Met Arg Gly 
        35                  40                  45              


Leu Gly Tyr His Ile Ser Asp Lys Asp Val Val Ser Lys Glu Ser Ile 
    50                  55                  60                  


Gln Gln Glu Arg Leu Ser Arg Ile Arg Arg Ala Gln Leu Glu Asn Gly 
65                  70                  75                  80  


Leu Pro Glu Pro Leu Gly Thr Asp Ala Glu Leu Asn Ser Leu Val Arg 
                85                  90                  95      


Lys Phe Tyr Glu Phe Ile Val Pro Ser Ser Val Lys Glu Asp Gly Asn 
            100                 105                 110         


Ala Gln Gln Ala Asn Gly Phe Leu Ser Pro Leu Thr Asp Pro Ile Ser 
        115                 120                 125             


Ile Gly Tyr Leu Ser Ile Phe Glu Lys Leu Gly Thr Ile Pro Asp Trp 
    130                 135                 140                 


Val Gly Gln Leu Lys Ala Gly Asp Pro Gln Ala Val Glu Asn Ala Lys 
145                 150                 155                 160 


Lys Trp Ser Ala Thr Ser Ala Gly Ile Lys Arg Leu Ser Glu Thr Gly 
                165                 170                 175     


Ala Pro Pro Lys Trp Lys Lys Leu Phe Leu Thr Gly Asp Pro Ser Trp 
            180                 185                 190         


Pro Gln Ser Phe Ser Glu Asp Ile Asp Lys Lys Ile Lys Glu Ile Glu 
        195                 200                 205             


Gly Ala Pro Lys Val Ile Cys Gln Leu Met Glu Met Gly Val Leu Pro 
    210                 215                 220                 


Leu Phe Pro Ala Tyr Phe Ala Asp Lys Leu Glu Gly Ser Asp Gly Ser 
225                 230                 235                 240 


Leu Ser Arg Trp Asp Arg Leu Ala Phe Arg Leu Ala Val Gly His Met 
                245                 250                 255     


Leu Ser Trp Glu Ser Trp Cys Ile Lys Ser Ala Glu Asp His Phe Glu 
            260                 265                 270         


Arg Lys Arg Arg Val Glu Ser Phe Ser Glu Lys His Thr Thr Pro Ser 
        275                 280                 285             


Leu Ile Ile Cys Phe Glu Thr Leu Glu Lys Tyr Gln Lys Glu Arg Gln 
    290                 295                 300                 


Glu Lys Glu Leu Gly Gln Asn Arg Ser Leu Pro Met Gln Arg Pro Phe 
305                 310                 315                 320 


Arg Ile Thr Arg Arg Gln Ile Arg Gly Trp Glu Asp Leu Arg Asp Lys 
                325                 330                 335     


Trp Leu Lys Asn Thr Thr Arg Thr Tyr Asp Ser Leu Lys Ser Ile Ala 
            340                 345                 350         


Ser Lys Glu Gln Thr Lys Lys Gly Gly Arg Phe Gly Asp Pro His Leu 
        355                 360                 365             


Phe Leu Trp Leu Ala Lys Pro Glu Asn His Ala Val Trp Asp Ala Asp 
    370                 375                 380                 


Glu Asp Ala Leu Ser Ile Phe Ala Lys Met Asn Ala Met Arg Gly Leu 
385                 390                 395                 400 


Leu Glu Arg Ser Arg Glu Thr Ala Tyr Met Thr Leu Pro Asp Pro Ile 
                405                 410                 415     


Glu His Pro Arg Ser Ile Gln Trp Glu Ala Glu Gly Gly Ser Asn Phe 
            420                 425                 430         


Lys Asn Tyr Val Ile Thr His Ser Pro Val Glu Gly Leu His Val Gln 
        435                 440                 445             


Leu Pro Leu Leu Cys Lys Ser Glu Ser Gly Lys Leu Ile Asp Gln Thr 
    450                 455                 460                 


Phe Glu Phe Pro Leu Ala Pro Ser Asp Gln Phe Lys Val Ala Gln Ile 
465                 470                 475                 480 


Ser Lys Thr Lys Ser Glu Val Thr Ile Thr His Gln Ser Val Leu Asp 
                485                 490                 495     


Glu Glu Tyr Arg Ser Lys Val Gly Ala Ala Asp Leu Leu Met Asp Trp 
            500                 505                 510         


Pro Tyr Leu Lys Asn Arg Arg Phe Glu Ser Val Glu His Gly Asp Ile 
        515                 520                 525             


Gly Pro Val Phe Leu Lys Leu Ser Leu Asp Ile Glu Arg Ile Leu Pro 
    530                 535                 540                 


Asp Gly Trp Thr Pro Lys Arg Pro Gln Ala Ile Ser His Phe Ser Ser 
545                 550                 555                 560 


Ala Ser Gly Asn Ser Lys His Lys Leu Ser Val Val Ser Gly Leu Arg 
                565                 570                 575     


Val Leu Ser Val Asp Leu Gly Ile Arg Ser Phe Gly Ala Cys Ser Val 
            580                 585                 590         


Phe Glu Leu Ser Glu His Lys Pro Thr Ser Gly Met Ser Phe Glu Ile 
        595                 600                 605             


Glu Gly Leu Asn Leu Trp Ala Asn His Glu Arg Ser Phe Met Leu Asn 
    610                 615                 620                 


Leu Pro Asp Glu Asp Val Gly Asn Lys Gly Arg Gln Leu Gln Lys Thr 
625                 630                 635                 640 


Lys Asp Ala Glu Leu Arg Ala Met Arg Arg Val Leu Gly Arg Tyr Arg 
                645                 650                 655     


Lys Ile Tyr Ala Leu Ala Gly Ile Asp Pro Glu Asp Arg Lys Asp Ile 
            660                 665                 670         


Leu Glu Leu Leu Cys Gln Asp Gln Asp Ile Phe Glu Phe Glu Arg Thr 
        675                 680                 685             


Ile Tyr Lys Gly Leu Val Thr Ser Thr Ser Val Ser Gln Pro Leu Trp 
    690                 695                 700                 


Glu Gly Lys Ile Lys Glu Ser Leu Lys Ala Leu Arg Asn Ala Phe Gly 
705                 710                 715                 720 


Arg Lys Val Arg Glu Trp Arg Arg Ala Asn Arg Leu Asn Ser Asn Leu 
                725                 730                 735     


Lys Tyr Ala Gly Lys Thr Met Trp Ala Ile Gln His Leu Glu Asp Thr 
            740                 745                 750         


Arg Arg Phe Leu His Ser Trp Ser His Leu Gly Arg Phe Ser Gly Glu 
        755                 760                 765             


Ile Arg Arg Ala Asp Arg Val Lys Arg Gly Val Phe Ala Thr Arg Leu 
    770                 775                 780                 


Leu Gln His Leu Asp Ser Val Lys Arg Asp Arg Leu Lys Thr Gly Ala 
785                 790                 795                 800 


Asp Leu Leu Val Gln Ser Ala Arg Gly Phe Leu Arg Asp Asn Gln Gly 
                805                 810                 815     


Asn Trp Lys Lys Ser Tyr Ala Pro Cys Gln Val Ile Leu Phe Glu Asp 
            820                 825                 830         


Leu Ser Arg Tyr Leu Met Gln Thr Asp Arg Pro Arg Arg Glu Asn Ser 
        835                 840                 845             


Gln Leu Met Lys Trp Ser His Arg Ser Ile Pro Leu Glu Val Ala Met 
    850                 855                 860                 


Gln Gly Glu Leu Tyr Gly Ile His Val Cys Asp Thr Ser Ala Ala Phe 
865                 870                 875                 880 


Ser Ser Arg Tyr His Ala Arg Leu Ala Thr Pro Gly Ile Arg Cys His 
                885                 890                 895     


Ala Leu Arg Lys Glu Asp Leu Ser Asn Gln Phe Leu Ile Glu Ser Leu 
            900                 905                 910         


Gln Lys Glu Asn Pro Asp Ile Asp Phe Gly Ile Cys Lys Ala Gly Asp 
        915                 920                 925             


Leu Ile Pro Arg Gly Gly Gly Glu Ile Phe Val Ser Cys Asp Gly Asn 
    930                 935                 940                 


Gly Gly Ile Ser Arg Ile His Ala Asp Ile Asn Ala Ala Gln Asn Leu 
945                 950                 955                 960 


Gln Arg Arg Phe Trp Leu Arg His Gly Glu Ala Ile Arg Ile Pro Ala 
                965                 970                 975     


Arg Lys Ile Thr Leu Lys Gly Asp Glu Ile Trp Val Pro Arg Ser Ile 
            980                 985                 990         


Gly Lys Arg Leu Gln Gly Ala Met  Ser Gly Cys Gly Tyr  Leu Ile Pro 
        995                 1000                 1005             


Thr Gly  His Glu Ser Gly Ser  Cys Arg Trp Glu Arg  Ile Thr Ala 
    1010                 1015                 1020             


Ser Lys  Trp Glu Ser Ile Ser  Arg Ser Ser Val Ala  Gln Lys Glu 
    1025                 1030                 1035             


Glu Val  Asn Glu Asp Leu Leu  Asp Ile Ala Leu Leu  Glu Glu Glu 
    1040                 1045                 1050             


Ala Leu  Glu Leu Ser Asn Glu  Tyr Thr Thr Phe Phe  Arg Asp Pro 
    1055                 1060                 1065             


Ser Gly  Ile Thr Leu Pro Ser  Asp Leu Trp Phe Pro  Met Lys Thr 
    1070                 1075                 1080             


Phe Trp  Gly Met Thr Arg Ala  Lys Ile Lys Ser Ala  Ile Lys Gln 
    1085                 1090                 1095             


<210> 598
<211> 1130
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 598
Met Thr Val Lys Ser Ile Lys Val Lys Leu Arg Leu Asp Asn Met Pro 
1               5                   10                  15      


Glu Ile Arg Ala Gly Leu Trp Lys Leu His Thr Glu Val Asn Ala Gly 
            20                  25                  30          


Val Arg Tyr Tyr Thr Glu Trp Leu Ser Leu Leu Arg Gln Glu Asn Leu 
        35                  40                  45              


Tyr Arg Arg Ser Pro Asn Gly Asp Gly Glu Gln Glu Cys Tyr Lys Thr 
    50                  55                  60                  


Ala Glu Glu Cys Lys Val Glu Leu Leu Glu Arg Leu Arg Ala Arg Gln 
65                  70                  75                  80  


Val Glu Asn Gly His Arg Asp Pro Ala Gly Ser Asp Asp Glu Leu Leu 
                85                  90                  95      


Gln Leu Ala Arg Gln Leu Tyr Glu Leu Leu Val Pro Gln Ala Ile Gly 
            100                 105                 110         


Ala Lys Gly Asp Ala Gln Gln Ile Ala Arg Lys Phe Leu Ser Pro Leu 
        115                 120                 125             


Ala Asp Lys Asp Ala Val Gly Gly Leu Gly Ile Ala Lys Ala Gly Asn 
    130                 135                 140                 


Lys Pro Arg Trp Val Arg Met Arg Asp Ala Gly Glu Pro Gly Trp Glu 
145                 150                 155                 160 


Glu Glu Lys Ala Lys Ala Glu Ala Arg Lys Ser Thr Asp Arg Thr Ala 
                165                 170                 175     


Asp Val Leu Arg Ala Leu Ala Asp Phe Gly Leu Lys Pro Leu Met Arg 
            180                 185                 190         


Val Tyr Thr Asp Ser Asp Met Ser Ser Val Gln Trp Lys Pro Leu Arg 
        195                 200                 205             


Lys Gly Gln Ala Val Arg Thr Trp Asp Arg Asp Met Phe Gln Gln Ala 
    210                 215                 220                 


Ile Glu Arg Met Met Ser Trp Glu Ser Trp Asn Gln Arg Val Gly Glu 
225                 230                 235                 240 


Ala Tyr Ala Lys Leu Val Glu Gln Lys Ser Arg Phe Glu Gln Lys Asn 
                245                 250                 255     


Phe Val Gly Gln Glu His Leu Val Gln Leu Val Asn Gln Leu Gln Gln 
            260                 265                 270         


Asp Met Lys Glu Ala Ser His Gly Leu Glu Ser Lys Glu Gln Thr Ala 
        275                 280                 285             


His Tyr Leu Thr Gly Arg Ala Leu Arg Gly Ser Asp Lys Val Phe Glu 
    290                 295                 300                 


Lys Trp Glu Lys Leu Asp Pro Asp Ala Pro Phe Asp Leu Tyr Asp Thr 
305                 310                 315                 320 


Glu Ile Lys Asn Val Gln Arg Arg Asn Thr Arg Arg Phe Gly Ser His 
                325                 330                 335     


Asp Leu Phe Ala Lys Leu Ala Glu Pro Lys Tyr Gln Ala Leu Trp Arg 
            340                 345                 350         


Glu Asp Ala Ser Phe Leu Thr Arg Tyr Ala Ala Tyr Asn Ser Ile Leu 
        355                 360                 365             


Arg Lys Leu Asn His Ala Lys Met Phe Ala Thr Phe Thr Leu Pro Asp 
    370                 375                 380                 


Ala Thr Ala His Pro Ile Trp Thr Arg Phe Asp Lys Leu Gly Gly Asn 
385                 390                 395                 400 


Leu His Gln Tyr Thr Phe Leu Phe Asn Glu Phe Gly Glu Gly Arg His 
                405                 410                 415     


Ala Ile Arg Phe Gln Lys Leu Leu Thr Ile Glu His Gly Val Ala Lys 
            420                 425                 430         


Glu Val Asp Asp Val Thr Val Pro Ile Ser Met Ser Ala Gln Leu Asp 
        435                 440                 445             


Asp Leu Leu Pro Gly Glu Ser Asn Glu Pro Thr Glu Leu Ser Phe Arg 
    450                 455                 460                 


Asp His Gly Thr Asp Gln His Phe Thr Gly Glu Phe Gly Gly Ala Lys 
465                 470                 475                 480 


Ile Gln Tyr Arg Arg Asp Gln Leu Asp His Val His Arg Arg Arg Gly 
                485                 490                 495     


Ala Arg Asp Val Tyr Leu Asn Leu Ser Val Arg Val Gln Ser Gln Ser 
            500                 505                 510         


Glu Ala Arg Gly Glu Arg Arg Pro Pro Tyr Ala Ala Val Phe Arg Leu 
        515                 520                 525             


Val Gly Asp Thr His Arg Ala Phe Ala His Phe Asp Lys Leu Ser Asn 
    530                 535                 540                 


Tyr Leu Ala Glu His Pro Asp Asp Gly Lys Leu Gly Ser Glu Gly Leu 
545                 550                 555                 560 


Leu Ser Gly Leu Arg Val Met Ser Val Asp Leu Gly Leu Arg Thr Ser 
                565                 570                 575     


Ala Ser Ile Ser Ile Phe Arg Val Ala Arg Lys Asp Glu Leu Lys Pro 
            580                 585                 590         


Asn Ser Glu Gly Arg Val Pro Phe Phe Phe Pro Ile Lys Gly Asn Asp 
        595                 600                 605             


Asn Leu Val Ala Val His Glu Arg Ser Gln Leu Leu Lys Leu Pro Gly 
    610                 615                 620                 


Glu Thr Glu Ser Lys Asp Leu Arg Ala Ile Arg Glu Glu Arg Gln Arg 
625                 630                 635                 640 


Ile Leu Arg Gln Leu Arg Thr Gln Leu Ala Tyr Leu Arg Leu Leu Val 
                645                 650                 655     


Arg Cys Gly Ser Glu Asp Val Gly Arg Arg Glu Arg Ser Trp Ala Lys 
            660                 665                 670         


Leu Ile Glu Gln Ser Val Asp Ala Ala Asn His Met Thr Pro Asp Trp 
        675                 680                 685             


Arg Glu Ala Phe Glu Gly Glu Leu Gln Lys Leu Lys Ser Leu Tyr Gly 
    690                 695                 700                 


Ile Cys Gly Asp Arg Glu Trp Thr Glu Ala Val Tyr Glu Ser Val Arg 
705                 710                 715                 720 


Arg Val Trp Arg His Met Gly Lys Gln Val Arg Asp Trp Arg Lys Asp 
                725                 730                 735     


Val Arg Ser Gly Glu Arg Pro Lys Ile Arg Gly Tyr Gln Lys Asp Val 
            740                 745                 750         


Val Gly Gly Asn Ser Ile Glu Gln Ile Glu Tyr Leu Glu Arg Gln Tyr 
        755                 760                 765             


Lys Phe Leu Lys Ser Trp Ser Phe Phe Gly Lys Val Ser Gly Gln Val 
    770                 775                 780                 


Ile Arg Ala Glu Lys Gly Ser Arg Phe Ala Thr Thr Leu Arg Glu His 
785                 790                 795                 800 


Ile Asp His Ala Lys Glu Asp Arg Leu Lys Lys Leu Ala Asp Arg Ile 
                805                 810                 815     


Ile Met Glu Ala Leu Gly Tyr Val Tyr Ala Leu Asp Ala Glu Arg Gly 
            820                 825                 830         


Lys Gly Thr Trp Val Ala Lys Tyr Pro Pro Cys Gln Leu Ile Leu Leu 
        835                 840                 845             


Glu Glu Leu Ser Glu Tyr Arg Phe Asn Asn Asp Arg Pro Pro Ser Glu 
    850                 855                 860                 


Asn Asn Gln Leu Met Gln Trp Ser His Arg Gly Val Phe Gln Glu Leu 
865                 870                 875                 880 


Leu Asn Gln Ala Gln Val His Asp Leu Leu Val Gly Thr Met Tyr Ala 
                885                 890                 895     


Ala Phe Ser Ser Arg Phe Asp Ala Arg Thr Gly Ala Pro Gly Ile Arg 
            900                 905                 910         


Cys Arg Arg Val Pro Ala Arg Cys Ala Arg Glu Gln Asn Pro Glu Pro 
        915                 920                 925             


Phe Pro Trp Trp Leu Asn Lys Phe Val Ala Glu His Lys Leu Asp Gly 
    930                 935                 940                 


Cys Pro Leu Arg Ala Asp Asp Leu Ile Pro Thr Gly Glu Gly Glu Phe 
945                 950                 955                 960 


Phe Val Ser Pro Phe Ser Ala Glu Glu Gly Asp Phe His Gln Ile His 
                965                 970                 975     


Ala Asp Leu Asn Ala Ala Gln Asn Leu Gln Arg Arg Leu Trp Ser Asp 
            980                 985                 990         


Phe Asp Ile Ser Gln Ile Arg Leu  Arg Cys Asp Trp Gly  Glu Val Asp 
        995                 1000                 1005             


Gly Glu  Pro Val Leu Ile Pro  Arg Leu Thr Gly Lys  Arg Thr Ala 
    1010                 1015                 1020             


Asp Ser  Tyr Gly Asn Lys Val  Phe Tyr Thr Asn Thr  Gly Val Thr 
    1025                 1030                 1035             


Tyr Tyr  Glu Arg Glu Arg Gly  Lys Lys Arg Arg Lys  Ala Phe Ala 
    1040                 1045                 1050             


Gln Glu  Glu Leu Ser Glu Glu  Glu Ala Glu Leu Leu  Val Glu Ala 
    1055                 1060                 1065             


Asp Glu  Ala Arg Glu Lys Ser  Val Val Leu Met Arg  Asp Pro Ser 
    1070                 1075                 1080             


Gly Ile  Ile Asn Arg Gly Asp  Trp Thr Arg Gln Lys  Glu Phe Trp 
    1085                 1090                 1095             


Ser Met  Val Asn Gln Arg Ile  Glu Gly Tyr Leu Val  Lys Gln Ile 
    1100                 1105                 1110             


Arg Ser  Arg Val Cys Leu Pro  Glu Ser Ala Cys Glu  Asn Thr Gly 
    1115                 1120                 1125             


Asp Ile  
    1130 


<210> 599
<211> 1333
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 599
Met Lys Asn Phe Gln Asp Phe Thr Asn Leu Tyr Glu Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Ile Gly Gly Thr Lys Lys Leu Ile Glu 
            20                  25                  30          


Glu Lys Asn Ile Leu Lys Leu Asp Lys Lys Lys Arg Glu Asn Tyr Glu 
        35                  40                  45              


Lys Val Lys Pro Tyr Phe Asn Lys Ile His Gln Glu Phe Ile Asn Phe 
    50                  55                  60                  


Ala Leu Arg Asn Pro Asn Phe Asp Phe Ser Gln Phe Glu Glu Lys Tyr 
65                  70                  75                  80  


Leu Asn Trp Leu Lys Asp Lys Lys Asn Lys Asp Leu Leu Lys Glu Lys 
                85                  90                  95      


Glu Ser Ile Asp Lys Ile Phe Leu Glu Lys Ile Gly Lys Leu Phe Glu 
            100                 105                 110         


Asn Ser Val Lys Asp Phe Leu Lys Glu Asn Gly Phe Glu Ser Ile Val 
        115                 120                 125             


Lys Glu Glu Asp Gln Asn Leu Lys Phe Phe Arg Arg Lys Glu Ile Phe 
    130                 135                 140                 


Glu Val Leu Gln Glu Lys Tyr Gly Ser Glu Leu Glu Thr Gln Met Val 
145                 150                 155                 160 


Asn Lys Asp Gly Glu Ile Lys Ser Ile Phe Asn Gly Trp Glu Lys Trp 
                165                 170                 175     


Leu Gly Tyr Phe Asp Lys Phe Phe Asn Thr Arg Asp Asn Phe Tyr Lys 
            180                 185                 190         


Thr Asp Gly Thr Ser Thr Ala Ile Ala Thr Arg Ile Ile Lys Asp Asn 
        195                 200                 205             


Leu Lys Ile Phe Leu Glu Asn Ile Val Ala Phe Gly Lys Ile Lys Asn 
    210                 215                 220                 


Lys Lys Ile Asp Phe Ser Glu Val Glu Lys Asn Phe Ser Val Ser Ile 
225                 230                 235                 240 


Asp Thr Phe Phe Glu Ile Asn Asn Phe Asn Asn Cys Phe Leu Gln Asp 
                245                 250                 255     


Gly Ile Asp Phe Tyr Asn Lys Val Ile Gly Gly Glu Thr Leu Glu Asn 
            260                 265                 270         


Gly Glu Lys Leu Lys Gly Leu Asn Glu Ile Ile Asn Lys Tyr Arg Gln 
        275                 280                 285             


Asp Thr Gly Glu Lys Ile Pro Tyr Phe Lys Lys Leu Gln Lys Gln Ile 
    290                 295                 300                 


Leu Ser Glu Lys Asp Gly Val Phe Ile Asp Lys Ile Glu Asp Asp Gly 
305                 310                 315                 320 


Gly Phe Tyr Glu Val Leu Lys Asn Phe Tyr Lys Asn Ala Ala Glu Lys 
                325                 330                 335     


Glu Gly Phe Leu Lys Asn Ile Phe Glu Asn Phe Tyr Thr Ile Ser Asp 
            340                 345                 350         


Lys Asn Leu Glu Lys Ile Tyr Phe Asn Lys Ile Ala Phe Asn Thr Ile 
        355                 360                 365             


Ser His Lys Phe Gly Ser Ala Leu Glu Phe Glu Arg Ile Leu Tyr Glu 
    370                 375                 380                 


Glu Met Lys Lys Glu Lys Ala Asp Gly Ile Lys Phe Glu Lys Lys Glu 
385                 390                 395                 400 


Asn Lys Tyr Lys Phe Pro Asp Phe Ile Gln Ile Ile Phe Ile Lys Arg 
                405                 410                 415     


Ser Leu Glu Asn Tyr Asp Ser Glu Asn Leu Phe Trp Lys Glu Arg Tyr 
            420                 425                 430         


Tyr Lys Ser Glu Glu Asn Val Asp Gly Phe Leu Glu Lys Asn Asn Asn 
        435                 440                 445             


Asn Leu Trp Gly Gln Phe Cys Lys Ile Leu Asn Phe Glu Phe Leu Asn 
    450                 455                 460                 


Ile Leu Lys Arg Arg Ile Ile Asp Glu Ala Gly Glu Glu Tyr Glu Val 
465                 470                 475                 480 


Gly Phe Glu Ile Ser Lys Asn Ile Leu Gly Glu Lys Leu Glu Asn Phe 
                485                 490                 495     


Glu Leu Asn Gln Glu Asn Lys Gly Ile Ile Lys Asp Phe Ala Asp Tyr 
            500                 505                 510         


Ser Leu Ala Leu Tyr Ser Phe Gly Lys Tyr Phe Ala Val Glu Lys Gly 
        515                 520                 525             


Arg Asn Trp Asp Leu Asn Ile Asp Ile Ser Asp Asp Phe Tyr Gly Gly 
    530                 535                 540                 


Glu Asp Gly Tyr Ile Glu Lys Phe Tyr Asn Thr Gly Tyr Asp Glu Ile 
545                 550                 555                 560 


Val Lys Pro Tyr Asn Leu Met Arg Asn Tyr Ile Ser Lys Lys Pro Trp 
                565                 570                 575     


Glu Asp Asn Lys Lys Trp Lys Ile Asn Phe Glu Thr Ser Ser Leu Leu 
            580                 585                 590         


Ser Gly Trp Asp Lys Asn Leu Glu Ser Asn Gly Ser Tyr Ile Phe Gln 
        595                 600                 605             


Lys Gly Asn Lys Tyr Tyr Leu Gly Ile Ile Asn Gly Ser Lys Pro Ala 
    610                 615                 620                 


Lys Glu Ile Leu Glu Lys Leu Tyr Ser Gly Asp Gly Glu Lys Ile Lys 
625                 630                 635                 640 


Arg Phe Ile Tyr Asp Phe Gln Lys Pro Asp Asn Lys Asn Thr Pro Arg 
                645                 650                 655     


Met Phe Ile Arg Ser Lys Lys Asp Ser Phe Ser Pro Ala Val Glu Lys 
            660                 665                 670         


Tyr Asn Leu Pro Ile Asn Asp Ile Leu Glu Ile Tyr Asp Asn Gly Leu 
        675                 680                 685             


Phe Lys Thr Glu Asn Lys Gly Asn Pro Asn Tyr Lys Glu Ser Leu Arg 
    690                 695                 700                 


Lys Leu Ile Asp Tyr Phe Lys Leu Gly Phe Ser Arg His Glu Ser Phe 
705                 710                 715                 720 


Lys His Phe Asn Phe Val Trp Lys Asp Ser Lys Ser Tyr Glu Asn Ile 
                725                 730                 735     


Ala Asp Phe Tyr Arg Asp Val Glu Lys Ser Cys Tyr Lys Ile Asp Phe 
            740                 745                 750         


Glu Phe Leu Asn Phe Glu Glu Leu Lys Lys Leu Thr Phe Glu Lys His 
        755                 760                 765             


Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Glu Leu Asp Glu Ser 
    770                 775                 780                 


Leu Gln Glu Lys Gly Tyr Asn Phe Lys Gly Glu Gly Gln Lys Asn Ile 
785                 790                 795                 800 


His Thr Lys Tyr Phe Glu Ala Leu Phe Leu Glu Glu Asn Ile Ser Arg 
                805                 810                 815     


Lys Ser Gly Ala Val Phe Lys Leu Ser Gly Gly Gly Glu Val Phe Phe 
            820                 825                 830         


Arg Lys Lys Ser Ile Lys Ala Lys Lys Glu Lys Arg Asn Ser Val Glu 
        835                 840                 845             


Val Ile Lys Asn Lys Arg Tyr Thr Glu Cys Lys Tyr Phe Leu His Phe 
    850                 855                 860                 


Pro Ile Gln Val Asn Phe Lys Glu Glu Ile Ser Gly Asn Phe Asn Gln 
865                 870                 875                 880 


Glu Ile Asn Lys Phe Leu Ala Asn Asn Pro Asp Ile Asn Val Ile Gly 
                885                 890                 895     


Ile Asp Arg Gly Glu Lys His Leu Ala Tyr Phe Ser Val Ile Asn Gln 
            900                 905                 910         


Lys Gly Glu Ile Leu Glu Ser Gly Ser Phe Asn Lys Ile Glu Asn Tyr 
        915                 920                 925             


Asn Lys Asn Gly Glu Lys Leu Leu Phe Pro Glu Arg Glu Ile Lys Glu 
    930                 935                 940                 


Ile His Lys Asp Gly Ser Leu Ile Asp Leu Glu Leu Val Glu Thr Gly 
945                 950                 955                 960 


Arg Lys Val Asp Tyr Val Asp Tyr Lys Leu Leu Leu Glu Tyr Lys Glu 
                965                 970                 975     


Arg Lys Arg Leu Leu Gln Arg Gln Ser Trp Lys Glu Val Glu Gln Ile 
            980                 985                 990         


Lys Asp Leu Lys Lys Gly Tyr Ile  Ser Ala Leu Val Arg  Lys Ile Ala 
        995                 1000                 1005             


Asp Leu  Ile Ile Lys His Asn  Ala Ile Val Ile Phe  Glu Asp Leu 
    1010                 1015                 1020             


Asn Phe  Arg Phe Lys Gln Ile  Arg Gly Gly Ile Glu  Lys Ser Ile 
    1025                 1030                 1035             


Tyr Gln  Gln Leu Glu Lys Ala  Leu Ile Asp Lys Leu  Asn Phe Leu 
    1040                 1045                 1050             


Val Asn  Lys Asn Glu Ile Asn  Leu Glu Lys Ala Gly  Ser Ile Leu 
    1055                 1060                 1065             


Lys Ala  Tyr Gln Leu Thr Val  Pro Val Asp Ser Leu  Lys Glu Ile 
    1070                 1075                 1080             


Gly Lys  Gln Thr Gly Val Ile  Phe Tyr Thr Glu Ala  Ala Tyr Thr 
    1085                 1090                 1095             


Ser Lys  Ile Asp Pro Ile Thr  Gly Trp Arg Pro Asn  Leu Tyr Leu 
    1100                 1105                 1110             


Lys Lys  Asn Asn Ser Lys Ile  Asn Lys Glu Asn Ile  Leu Lys Phe 
    1115                 1120                 1125             


Asp Asn  Ile Val Phe Asn Ser  Lys Glu Asn Arg Phe  Glu Phe Thr 
    1130                 1135                 1140             


Tyr Asp  Leu Lys Lys Phe Phe  Gly Lys Asp Ser Lys  Phe Pro Ala 
    1145                 1150                 1155             


Lys Thr  Val Asn Thr Val Cys  Ser Cys Val Glu Arg  Phe Lys Trp 
    1160                 1165                 1170             


Asn Arg  Asn Leu Asn Asn Asn  Lys Gly Gly Tyr Ile  His Tyr Glu 
    1175                 1180                 1185             


Asn Leu  Thr Asp Gly Lys Leu  Ala Asn Lys Glu Gln  Lys Glu Asp 
    1190                 1195                 1200             


Glu Phe  Ser Asn Phe Lys Glu  Leu Phe Glu Lys Tyr  Phe Ile Asp 
    1205                 1210                 1215             


Ile Asn  Gly Asn Ile Leu Glu  Gln Ile Lys Asn Leu  Asp Thr Lys 
    1220                 1225                 1230             


Asn Asn  Glu Lys Phe Phe Ser  Ser Phe Ile Asp Leu  Phe Thr Leu 
    1235                 1240                 1245             


Val Cys  Gln Ile Arg Asn Thr  Asn Gln Asn Ala Lys  Gly Asp Glu 
    1250                 1255                 1260             


Asn Asp  Phe Ile Leu Ser Pro  Val Glu Pro Phe Phe  Asp Ser Arg 
    1265                 1270                 1275             


Lys Ser  Gln Asn Phe Gly Lys  Ser Leu Pro Lys Asn  Gly Asp Glu 
    1280                 1285                 1290             


Asn Gly  Ala Phe Asn Ile Ala  Arg Lys Gly Leu Ile  Ile Leu Asn 
    1295                 1300                 1305             


Arg Ile  Ser Glu Asn Pro Glu  Lys Pro Asp Leu Leu  Ile Phe Asn 
    1310                 1315                 1320             


Ala Asp  Trp Asp Asn Phe Ala  Arg Asn Ile 
    1325                 1330             


<210> 600
<211> 606
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 600
Met Ala Gln Ala Glu Ala Pro Arg Arg Leu Arg Ala Tyr Lys Phe Ala 
1               5                   10                  15      


Leu Asp Pro Thr Glu Ala Gln Leu Arg Glu Phe Glu Gln His Ala Gly 
            20                  25                  30          


Ser Ala Arg Trp Ala Tyr Asn His Ala Asn Ala Ile Leu Ser Arg Tyr 
        35                  40                  45              


Ser Asp Thr Leu Arg Asn Arg Trp Asn Ala Trp Ile Ala Gln His His 
    50                  55                  60                  


Gly Leu Ser Arg Glu Gln Leu Tyr Ala Leu Pro Asp Arg Glu Arg Thr 
65                  70                  75                  80  


Ala Ile Gln Ala Ala Ala Arg Ala Ala Val Lys Ala Glu Asn Ala Gln 
                85                  90                  95      


Leu Ala Ala Glu Leu Arg Ile Ile Asp Asp His Arg Lys Arg Val Thr 
            100                 105                 110         


His Lys Gly Lys Pro Ser Val Glu Pro Gly Glu Gln Pro Ala Glu Asp 
        115                 120                 125             


Ala Pro Glu Arg Ala Tyr Gln Leu Trp Arg Glu Arg Val Glu Leu Ala 
    130                 135                 140                 


Arg Leu His Ala Glu Asp Pro Gln Ala Tyr Arg Ala Glu Arg Lys Arg 
145                 150                 155                 160 


Ile Leu Asp Glu Ile Arg Pro Leu Val Asn Ala Thr Lys Arg Lys Leu 
                165                 170                 175     


Ile Glu Gln Gly Ala Tyr Arg Pro Thr Ala Met Asp Ile Ser Thr Leu 
            180                 185                 190         


Trp Arg Glu Ile Arg Asp Leu Pro Pro Asp Glu Gly Gly Ser Pro Trp 
        195                 200                 205             


Trp Pro Glu Val Ser Ile Tyr Ala Phe Thr Ser Gly Phe Ala His Ala 
    210                 215                 220                 


Glu Thr Ala Trp Lys Asn Tyr Leu Glu Ser Leu Ala Gly Arg Arg Ala 
225                 230                 235                 240 


Gly Arg Pro Val Gly Lys Pro Arg Phe Lys Lys Lys Arg Arg Ser Arg 
                245                 250                 255     


Arg Ser Phe Thr Leu Tyr Gly Ser Val Lys Leu Val Thr Tyr Arg Arg 
            260                 265                 270         


Ile Gln Val Pro Ser Ile Gly Ser Val Arg Leu His Gly Ser Ala Lys 
        275                 280                 285             


Arg Leu His Arg Ala Leu Glu Arg Arg Gly Gly Ile Ile Lys Ser Ile 
    290                 295                 300                 


Thr Ile Ser Gln Gly Gly His Arg Trp Tyr Ala Ser Val Leu Val Asp 
305                 310                 315                 320 


Glu Leu Asp Ile Thr Pro Gly Arg Glu Thr Gln Arg Gly Pro Ser Arg 
                325                 330                 335     


Arg Gln Arg Asp Arg Gly Ala Val Gly Val Asp Leu Gly Val His His 
            340                 345                 350         


Leu Val Ala Leu Ser Asp Pro Asn Glu Lys Thr Leu Asp Asn Pro Arg 
        355                 360                 365             


His Leu Arg Lys Ala Arg Lys Arg Leu Leu Lys Ala Gln Arg Ala Met 
    370                 375                 380                 


Ser Arg Arg Arg Gly Pro Asp Lys Arg Thr Gly Gln Glu Pro Ser Arg 
385                 390                 395                 400 


Arg Trp Val Lys Ala Arg Asn Arg Val Ala Arg Leu His His Glu Leu 
                405                 410                 415     


Ala Val Arg Arg Ala Gly His Leu His Glu Ile Thr Lys Arg Leu Ala 
            420                 425                 430         


Thr Ser Tyr Glu Leu Val Ala Ile Glu Asp Leu Asn Val Ala Gly Met 
        435                 440                 445             


Thr Arg Ser Ala Arg Gly Thr Ile Asp Gln Pro Gly Arg Gly Val Arg 
    450                 455                 460                 


Ala Lys Ala Gly Leu Asn Arg Ser Ile Leu Asp Thr Ser Pro Ala Glu 
465                 470                 475                 480 


Phe Arg Arg Gln Leu Gln Tyr Lys Ala Ser Trp Tyr Gly Ala Thr Val 
                485                 490                 495     


Ala Val Ile Asp Arg Trp Ala Pro Thr Ser Arg Thr Cys Ser Ser Cys 
            500                 505                 510         


Gly Ala Val Lys Ala Lys Leu Ser Leu Ala Glu Arg Thr Phe Phe Cys 
        515                 520                 525             


Glu His Cys Gly Met Glu Leu Asp Arg Asp Ile Asn Ala Ala Arg Asn 
    530                 535                 540                 


Ile Leu Ala Phe Ala Gln Ser Ala Tyr Pro Gly Glu Gly Lys Ala Leu 
545                 550                 555                 560 


Asn Ala Cys Gly Gly Ser Val Ser Pro Gly Ser Gln Ser Val Val Gln 
                565                 570                 575     


Ala Gly Ala Asp Glu Ala Gly Arg Pro Ala Arg Lys Pro Arg Arg Ser 
            580                 585                 590         


Ser Arg Gly Ser Asp Pro Pro Ala Thr Pro Thr Thr Arg Ala 
        595                 600                 605     


<210> 601
<211> 1193
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 601
Met Lys Arg Ile Ala Lys Phe Arg His Asp Lys Pro Val Lys Arg Glu 
1               5                   10                  15      


Ala Trp Ser Lys Gly Tyr Arg Val His Lys Asn Arg Ile Ile Asn Lys 
            20                  25                  30          


Val Thr Arg Ser Ile Lys Tyr Pro Leu Val Val Lys Asp Glu Trp Lys 
        35                  40                  45              


Lys Arg Leu Ile Asp Asp Ala Ala His Asp Tyr Arg Trp Leu Val Gly 
    50                  55                  60                  


Pro Ile Asn Tyr Ser Asp Trp Cys Arg Asp Pro Asn Gln Tyr Ser Ile 
65                  70                  75                  80  


Leu Glu Phe Trp Ile Asp Phe Leu Cys Val Gly Gly Val Phe Gln Ser 
                85                  90                  95      


Ser His Ser Asn Ile Cys Arg Leu Ala Ile Gln Leu Ser Gly Gly Ser 
            100                 105                 110         


Val Phe Glu Gln Glu Trp Lys Asp Leu Ser Pro Phe Val Arg Ala Asn 
        115                 120                 125             


Leu Ile Gln Gly Ile Lys Pro Ala Glu Phe Ile Gly Phe Leu Thr Ala 
    130                 135                 140                 


Glu Phe Arg Ser Ser Ser Asn Pro Lys Asn Phe Ile Ser Lys Phe Phe 
145                 150                 155                 160 


Glu Gly Ser Asn Glu Asp Leu Glu Ser Leu Thr Asn Glu Phe Ala Ser 
                165                 170                 175     


Ile Val Asp Phe Ile Lys Ala Lys Asp Ile Ser Leu Leu Arg Lys Ser 
            180                 185                 190         


Leu Pro Ser Cys Lys Lys Ile Ala Pro Asn Leu Trp Glu Lys Ala Val 
        195                 200                 205             


Gly Ser His Ser Thr Asn Glu Leu Leu Lys Leu Leu Thr Lys Tyr Thr 
    210                 215                 220                 


Arg Val Met Leu Val Ala Glu Pro Ser His Ser Asp Arg Val Phe Ser 
225                 230                 235                 240 


Gln Thr Val Leu Gln Ser Asn Asp Gln Asp Asp Pro Glu Leu Thr Gly 
                245                 250                 255     


Pro Leu Pro Ser His Lys Val Gly Lys Ala Ser Tyr Leu Phe Ile Pro 
            260                 265                 270         


Glu Phe Ile Arg Glu Val Asn Leu Asp Lys Ile Ser Lys Leu Asp Leu 
        275                 280                 285             


Ser Ala Lys Ser Lys Leu Ala Val Glu Gln Val Lys Lys Leu Ser Glu 
    290                 295                 300                 


Leu Thr Ser Asp Phe Lys Gln Ile Glu Asn Gln Ser Glu Ala Tyr Phe 
305                 310                 315                 320 


Gly Leu Ser Thr Ser Phe Asn Glu Leu Ser Asn Phe Leu Gly Ile Leu 
                325                 330                 335     


Ile Arg Thr Leu Arg Asn Ala Pro Glu Ala Ile Leu Lys Asp Gln Ile 
            340                 345                 350         


Ala Leu Cys Ala Pro Leu Asp Lys Asp Ile Leu Lys Ile Thr Leu Asp 
        355                 360                 365             


Trp Leu Cys Asp Arg Ala Gln Ala Leu Pro Glu Asn Pro Arg Phe Glu 
    370                 375                 380                 


Thr Asn Trp Ala Glu Tyr Arg Ser Tyr Leu Gly Gly Lys Ile Lys Ser 
385                 390                 395                 400 


Trp Phe Ser Asn Tyr Glu Asn Phe Phe Glu Ile Pro Gln Ala Ala Ser 
                405                 410                 415     


Ser Gln Gln Asn Asn Asn Arg Glu Lys Lys Leu Gly Asn Arg Ser Ala 
            420                 425                 430         


Ile Arg Ala Leu Asn Leu Lys Lys Glu Ala Phe Glu Lys Ala Arg Glu 
        435                 440                 445             


Thr Phe Lys Gly Asp Lys Gly Thr Leu Glu Lys Ile Asp Leu Ala Tyr 
    450                 455                 460                 


Arg Leu Leu Gly Ser Ile Ser Pro Glu Val Leu Gln Cys Asp Glu Gly 
465                 470                 475                 480 


Leu Lys Leu Tyr Gln Gln Phe Asn Asp Glu Leu Leu Val Leu Asn Glu 
                485                 490                 495     


Thr Ile Asn Gln Lys Phe Gln Asp Ala Lys Arg Asp Ile Lys Ala Lys 
            500                 505                 510         


Lys Glu Lys Glu Ser Phe Glu Lys Leu Gln Arg Asn Leu Ser Ser Pro 
        515                 520                 525             


Leu Pro Arg Ile Pro Glu Phe Phe Gly Glu Arg Ala Lys Lys Gly Tyr 
    530                 535                 540                 


Gln Lys Ala Arg Val Ser Pro Lys Leu Ala Arg His Leu Leu Glu Cys 
545                 550                 555                 560 


Leu Asn Asp Trp Leu Ala Arg Phe Ala Lys Val Glu Glu Ser Ala Phe 
                565                 570                 575     


Ser Glu Lys Glu Phe Gln Arg Ile Leu Asp Trp Leu Arg Thr Ser Asp 
            580                 585                 590         


Phe Leu Pro Val Phe Ile Arg Lys Ser Lys Asp Pro Pro Ser Trp Leu 
        595                 600                 605             


Arg Tyr Ile Ala Arg Val Ala Thr Gly Lys Tyr Tyr Phe Trp Val Ser 
    610                 615                 620                 


Glu Tyr Ser Arg Lys Arg Val Gln Ile Ile Asp Lys Pro Ile Ala Gln 
625                 630                 635                 640 


Asn Pro Leu Lys Glu Leu Ile Ser Trp Phe Leu Leu Asn Lys Asp Ala 
                645                 650                 655     


Phe Ser Arg Asp Asn Glu Leu Phe Lys Gly Leu Ser Ser Lys Met Val 
            660                 665                 670         


Thr Leu Ala Arg Ile Met Ala Gly Ile Leu Arg Asp Arg Gly Glu Gly 
        675                 680                 685             


Leu Lys Glu Leu Gln Ala Met Thr Ser Lys Leu Asp Asn Ile Gly Leu 
    690                 695                 700                 


Leu His Pro Ser Phe Ser Val Pro Val Thr Asp Ser Leu Lys Asp Ala 
705                 710                 715                 720 


Ala Phe Tyr Arg Ala Phe Phe Ser Glu Leu Glu Gly Leu Leu Asn Ile 
                725                 730                 735     


Gly Arg Ser Arg Leu Ile Ile Glu Arg Ile Thr Leu Gln Ser Gln Gln 
            740                 745                 750         


Ser Lys Asn Lys Lys Thr Arg Arg Pro Leu Met Pro Glu Pro Phe Ile 
        755                 760                 765             


Asn Glu Asp Lys Glu Val Phe Leu Ala Phe Pro Lys Phe Glu Thr Lys 
    770                 775                 780                 


Asn Lys Val Lys Gly Thr Arg Val Val Tyr Asn Ser Pro Asp Glu Val 
785                 790                 795                 800 


Asn Trp Leu Leu Ser Pro Ile Arg Ser Ser Lys Gly Gln Leu Ser Phe 
                805                 810                 815     


Met Phe Arg Cys Leu Ser Glu Asp Ala Lys Ile Met Thr Thr Ser Gly 
            820                 825                 830         


Gly Cys Ser Tyr Ile Val Glu Phe Lys Lys Leu Leu Glu Ala Gln Glu 
        835                 840                 845             


Glu Val Leu Ser Ile His Asp Cys Asp Ile Ile Pro Arg Ala Phe Val 
    850                 855                 860                 


Ser Ile Pro Phe Thr Leu Glu Arg Glu Ser Glu Glu Thr Lys Pro Asp 
865                 870                 875                 880 


Trp Lys Pro Asn Arg Phe Met Gly Val Asp Ile Gly Glu Tyr Ala Val 
                885                 890                 895     


Ala Tyr Cys Val Ile Glu Lys Gly Thr Asp Ser Ile Glu Ile Leu Asp 
            900                 905                 910         


Cys Gly Ile Val Arg Asn Gly Ala His Arg Val Leu Lys Glu Lys Val 
        915                 920                 925             


Asp Arg Leu Lys Arg Arg Gln Arg Ser Met Thr Phe Gly Ala Met Asp 
    930                 935                 940                 


Thr Ser Ile Ala Ala Ala Arg Glu Ser Leu Val Gly Asn Tyr Arg Asn 
945                 950                 955                 960 


Arg Leu His Ala Ile Ala Leu Lys His Gly Ala Lys Leu Val Tyr Glu 
                965                 970                 975     


Tyr Glu Val Ser Ala Phe Glu Ser Gly Gly Asn Arg Ile Lys Lys Val 
            980                 985                 990         


Tyr Glu Thr Leu Lys Lys Ser Asp  Cys Thr Gly Glu Thr  Glu Ala Asp 
        995                 1000                 1005             


Lys Asn  Ala Arg Lys His Ile  Trp Gly Glu Thr Asn  Ala Val Gly 
    1010                 1015                 1020             


Asp Gln  Ile Gly Ala Gly Trp  Thr Ser Gln Thr Cys  Ala Lys Cys 
    1025                 1030                 1035             


Gly Arg  Ser Phe Gly Ala Asp  Leu Lys Ala Gly Asn  Phe Gly Val 
    1040                 1045                 1050             


Ala Val  Pro Val Pro Glu Lys  Val Glu Asp Ser Lys  Gly His Tyr 
    1055                 1060                 1065             


Ala Tyr  His Glu Phe Pro Phe  Glu Asp Gly Leu Lys  Val Arg Gly 
    1070                 1075                 1080             


Phe Leu  Lys Pro Asn Lys Ile  Ile Ser Asp Gln Lys  Glu Leu Ala 
    1085                 1090                 1095             


Lys Ala  Val His Ala Tyr Met  Arg Pro Pro Leu Val  Ala Leu Gly 
    1100                 1105                 1110             


Lys Arg  Lys Leu Pro Lys Asn  Ala Arg Tyr Arg Arg  Gly Asn Ser 
    1115                 1120                 1125             


Ser Leu  Phe Arg Cys Pro Phe  Ser Asp Cys Gly Phe  Thr Ala Asp 
    1130                 1135                 1140             


Ala Asp  Ile Gln Ala Ala Tyr  Asn Ile Ala Val Lys  Gln Leu Tyr 
    1145                 1150                 1155             


Lys Pro  Lys Lys Gly Tyr Pro  Lys Glu Arg Lys Trp  Gln Asp Phe 
    1160                 1165                 1170             


Val Ile  Leu Lys Pro Lys Glu  Pro Ser Lys Leu Phe  Asp Lys Gln 
    1175                 1180                 1185             


Phe Tyr  Arg Pro Asn 
    1190             


<210> 602
<211> 606
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 602
Met Ala Gln Ala Glu Ala Pro Arg Arg Leu Arg Ala Tyr Lys Phe Ala 
1               5                   10                  15      


Leu Asp Pro Thr Glu Ala Gln Leu Arg Glu Phe Glu Gln His Ala Gly 
            20                  25                  30          


Ser Ala Arg Trp Ala Tyr Asn His Ala Asn Ala Ile Leu Ser Arg Tyr 
        35                  40                  45              


Ser Asp Thr Leu Arg Asn Arg Trp Asn Ala Trp Ile Ala Gln His His 
    50                  55                  60                  


Gly Leu Ser Arg Glu Gln Leu Tyr Ala Leu Pro Asp Arg Glu Arg Thr 
65                  70                  75                  80  


Ala Ile Gln Ala Ala Ala Arg Ala Ala Val Lys Ala Glu Asn Ala Gln 
                85                  90                  95      


Leu Ala Ala Glu Leu Arg Ile Ile Asp Asp His Arg Lys Arg Val Thr 
            100                 105                 110         


His Lys Gly Lys Pro Ser Val Glu Pro Gly Glu Gln Pro Ala Glu Asp 
        115                 120                 125             


Ala Pro Glu Arg Ala Tyr Gln Leu Trp Arg Glu Arg Val Glu Leu Ala 
    130                 135                 140                 


Arg Leu His Ala Glu Asp Pro Gln Ala Tyr Arg Ala Glu Arg Lys Arg 
145                 150                 155                 160 


Ile Leu Asp Glu Ile Arg Pro Leu Val Asn Ala Thr Lys Arg Lys Leu 
                165                 170                 175     


Ile Glu Gln Gly Ala Tyr Arg Pro Thr Ala Met Asp Ile Ser Thr Leu 
            180                 185                 190         


Trp Arg Glu Ile Arg Asp Leu Pro Pro Asp Glu Gly Gly Ser Pro Trp 
        195                 200                 205             


Trp Pro Glu Val Ser Ile Tyr Ala Phe Thr Ser Gly Phe Ala His Ala 
    210                 215                 220                 


Glu Thr Ala Trp Lys Asn Tyr Leu Glu Ser Leu Ala Gly Arg Arg Ala 
225                 230                 235                 240 


Gly Arg Pro Val Gly Lys Pro Arg Phe Lys Lys Lys Arg Arg Ser Arg 
                245                 250                 255     


Arg Ser Phe Thr Leu Tyr Gly Ser Val Lys Leu Val Thr Tyr Arg Arg 
            260                 265                 270         


Ile Gln Val Pro Ser Ile Gly Ser Val Arg Leu His Gly Ser Ala Lys 
        275                 280                 285             


Arg Leu His Arg Ala Leu Glu Arg Arg Gly Gly Ile Ile Lys Ser Ile 
    290                 295                 300                 


Thr Ile Ser Gln Gly Gly His Arg Trp Tyr Ala Ser Val Leu Val Asp 
305                 310                 315                 320 


Glu Leu Asp Ile Thr Pro Gly Arg Glu Thr Gln Arg Gly Pro Ser Arg 
                325                 330                 335     


Arg Gln Arg Asp Arg Gly Ala Val Gly Val Asp Leu Gly Val His His 
            340                 345                 350         


Leu Val Ala Leu Ser Asp Pro Asn Glu Lys Thr Leu Asp Asn Pro Arg 
        355                 360                 365             


His Leu Arg Lys Ala Arg Lys Arg Leu Leu Lys Ala Gln Arg Ala Met 
    370                 375                 380                 


Ser Arg Arg Arg Gly Pro Asp Lys Arg Thr Gly Gln Glu Pro Ser Arg 
385                 390                 395                 400 


Arg Trp Val Lys Ala Arg Asn Arg Val Ala Arg Leu His His Glu Leu 
                405                 410                 415     


Ala Val Arg Arg Ala Gly His Leu His Glu Ile Thr Lys Arg Leu Ala 
            420                 425                 430         


Thr Ser Tyr Glu Leu Val Ala Ile Glu Asp Leu Asn Val Ala Gly Met 
        435                 440                 445             


Thr Arg Ser Ala Arg Gly Thr Ile Asp Gln Pro Gly Arg Gly Val Arg 
    450                 455                 460                 


Ala Lys Ala Gly Leu Asn Arg Ser Ile Leu Asp Thr Ser Pro Ala Glu 
465                 470                 475                 480 


Phe Arg Arg Gln Leu Gln Tyr Lys Ala Ser Trp Tyr Gly Ala Thr Val 
                485                 490                 495     


Ala Val Ile Asp Arg Trp Ala Pro Thr Ser Arg Thr Cys Ser Ser Cys 
            500                 505                 510         


Gly Ala Val Lys Ala Lys Leu Ser Leu Ala Glu Arg Thr Phe Phe Cys 
        515                 520                 525             


Glu His Cys Gly Met Glu Leu Asp Arg Asp Ile Asn Ala Ala Arg Asn 
    530                 535                 540                 


Ile Leu Ala Phe Ala Gln Ser Ala Tyr Pro Gly Glu Gly Lys Ala Leu 
545                 550                 555                 560 


Asn Ala Cys Gly Gly Ser Val Ser Pro Gly Ser Gln Ser Val Val Gln 
                565                 570                 575     


Ala Gly Ala Asp Glu Ala Gly Arg Pro Ala Arg Lys Pro Arg Arg Ser 
            580                 585                 590         


Ser Arg Gly Ser Asp Pro Pro Ala Thr Pro Thr Thr Arg Ala 
        595                 600                 605     


<210> 603
<211> 1108
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 603
Met Ala Ile Arg Ser Ile Lys Leu Lys Leu Lys Thr His Thr Gly Pro 
1               5                   10                  15      


Glu Ala Gln Asn Leu Arg Lys Gly Ile Trp Arg Thr His Arg Leu Leu 
            20                  25                  30          


Asn Glu Gly Val Ala Tyr Tyr Met Lys Met Leu Leu Leu Phe Arg Gln 
        35                  40                  45              


Glu Ser Thr Gly Glu Arg Pro Lys Glu Glu Leu Gln Glu Glu Leu Ile 
    50                  55                  60                  


Cys His Ile Arg Glu Gln Gln Gln Arg Asn Gln Ala Asp Lys Asn Thr 
65                  70                  75                  80  


Gln Ala Leu Pro Leu Asp Lys Ala Leu Glu Ala Leu Arg Gln Leu Tyr 
                85                  90                  95      


Glu Leu Leu Val Pro Ser Ser Val Gly Gln Ser Gly Asp Ala Gln Ile 
            100                 105                 110         


Ile Ser Arg Lys Phe Leu Ser Pro Leu Val Asp Pro Asn Ser Glu Gly 
        115                 120                 125             


Gly Lys Gly Thr Ser Lys Ala Gly Ala Lys Pro Thr Trp Gln Lys Lys 
    130                 135                 140                 


Lys Glu Ala Asn Asp Pro Thr Trp Glu Gln Asp Tyr Glu Lys Trp Lys 
145                 150                 155                 160 


Lys Arg Arg Glu Glu Asp Pro Thr Ala Ser Val Ile Thr Thr Leu Glu 
                165                 170                 175     


Glu Tyr Gly Ile Arg Pro Ile Phe Pro Leu Tyr Thr Asn Thr Val Thr 
            180                 185                 190         


Asp Ile Ala Trp Leu Pro Leu Gln Ser Asn Gln Phe Val Arg Thr Trp 
        195                 200                 205             


Asp Arg Asp Met Leu Gln Gln Ala Ile Glu Arg Leu Leu Ser Trp Glu 
    210                 215                 220                 


Ser Trp Asn Lys Arg Val Gln Glu Glu Tyr Ala Lys Leu Lys Glu Lys 
225                 230                 235                 240 


Met Ala Gln Leu Asn Glu Gln Leu Glu Gly Gly Gln Glu Trp Ile Ser 
                245                 250                 255     


Leu Leu Glu Gln Tyr Glu Glu Asn Arg Glu Arg Glu Leu Arg Glu Asn 
            260                 265                 270         


Met Thr Ala Ala Asn Asp Lys Tyr Arg Ile Thr Lys Arg Gln Met Lys 
        275                 280                 285             


Gly Trp Asn Glu Leu Tyr Glu Leu Trp Ser Thr Phe Pro Ala Ser Ala 
    290                 295                 300                 


Ser His Glu Gln Tyr Lys Glu Ala Leu Lys Arg Val Gln Gln Arg Leu 
305                 310                 315                 320 


Arg Gly Arg Phe Gly Asp Ala His Phe Phe Gln Tyr Leu Met Glu Glu 
                325                 330                 335     


Lys Asn Arg Leu Ile Trp Lys Gly Asn Pro Gln Arg Ile His Tyr Phe 
            340                 345                 350         


Val Ala Arg Asn Glu Leu Thr Lys Arg Leu Glu Glu Ala Lys Gln Ser 
        355                 360                 365             


Ala Thr Met Thr Leu Pro Asn Ala Arg Lys His Pro Leu Trp Val Arg 
    370                 375                 380                 


Phe Asp Ala Arg Gly Gly Asn Leu Gln Asp Tyr Tyr Leu Thr Ala Glu 
385                 390                 395                 400 


Ala Asp Lys Pro Arg Ser Arg Arg Phe Val Thr Phe Ser Gln Leu Ile 
                405                 410                 415     


Trp Pro Ser Glu Ser Gly Trp Met Glu Lys Lys Asp Val Glu Val Glu 
            420                 425                 430         


Leu Ala Leu Ser Arg Gln Phe Tyr Gln Gln Val Lys Leu Leu Lys Asn 
        435                 440                 445             


Asp Lys Gly Lys Gln Lys Ile Glu Phe Lys Asp Lys Gly Ser Gly Ser 
    450                 455                 460                 


Thr Phe Asn Gly His Leu Gly Gly Ala Lys Leu Gln Leu Glu Arg Gly 
465                 470                 475                 480 


Asp Leu Glu Lys Glu Glu Lys Asn Phe Glu Asp Gly Glu Ile Gly Ser 
                485                 490                 495     


Val Tyr Leu Asn Val Val Ile Asp Phe Glu Pro Leu Gln Glu Val Lys 
            500                 505                 510         


Asn Gly Arg Val Gln Ala Pro Tyr Gly Gln Val Leu Gln Leu Ile Arg 
        515                 520                 525             


Arg Pro Asn Glu Phe Pro Lys Val Thr Thr Tyr Lys Ser Glu Gln Leu 
    530                 535                 540                 


Val Glu Trp Ile Lys Ala Ser Pro Gln His Ser Ala Gly Val Glu Ser 
545                 550                 555                 560 


Leu Ala Ser Gly Phe Arg Val Met Ser Ile Asp Leu Gly Leu Arg Ala 
                565                 570                 575     


Ala Ala Ala Thr Ser Ile Phe Ser Val Glu Glu Ser Ser Asp Lys Asn 
            580                 585                 590         


Ala Ala Asp Phe Ser Tyr Trp Ile Glu Gly Thr Pro Leu Val Ala Val 
        595                 600                 605             


His Gln Arg Ser Tyr Met Leu Arg Leu Pro Gly Glu Gln Val Glu Lys 
    610                 615                 620                 


Gln Val Met Glu Lys Arg Asp Glu Arg Phe Gln Leu His Gln Arg Val 
625                 630                 635                 640 


Lys Phe Gln Ile Arg Val Leu Ala Gln Ile Met Arg Met Ala Asn Lys 
                645                 650                 655     


Gln Tyr Gly Asp Arg Trp Asp Glu Leu Asp Ser Leu Lys Gln Ala Val 
            660                 665                 670         


Glu Gln Lys Lys Ser Pro Leu Asp Gln Thr Asp Arg Thr Phe Trp Glu 
        675                 680                 685             


Gly Ile Val Cys Asp Leu Thr Lys Val Leu Pro Arg Asn Glu Ala Asp 
    690                 695                 700                 


Trp Glu Gln Ala Val Val Gln Ile His Arg Lys Ala Glu Glu Tyr Val 
705                 710                 715                 720 


Gly Lys Ala Val Gln Ala Trp Arg Lys Arg Phe Ala Ala Asp Glu Arg 
                725                 730                 735     


Lys Gly Ile Ala Gly Leu Ser Met Trp Asn Ile Glu Glu Leu Glu Gly 
            740                 745                 750         


Leu Arg Lys Leu Leu Ile Ser Trp Ser Arg Arg Thr Arg Asn Pro Gln 
        755                 760                 765             


Glu Val Asn Arg Phe Glu Arg Gly His Thr Ser His Gln Arg Leu Leu 
    770                 775                 780                 


Thr His Ile Gln Asn Val Lys Glu Asp Arg Leu Lys Gln Leu Ser His 
785                 790                 795                 800 


Ala Ile Val Met Thr Ala Leu Gly Tyr Val Tyr Asp Glu Arg Lys Gln 
                805                 810                 815     


Glu Trp Cys Ala Glu Tyr Pro Ala Cys Gln Val Ile Leu Phe Glu Asn 
            820                 825                 830         


Leu Ser Gln Tyr Arg Ser Asn Leu Asp Arg Ser Thr Lys Glu Asn Ser 
        835                 840                 845             


Thr Leu Met Lys Trp Ala His Arg Ser Ile Pro Lys Tyr Val His Met 
    850                 855                 860                 


Gln Ala Glu Pro Tyr Gly Ile Gln Ile Gly Asp Val Arg Ala Glu Tyr 
865                 870                 875                 880 


Ser Ser Arg Phe Tyr Ala Lys Thr Gly Thr Pro Gly Ile Arg Cys Lys 
                885                 890                 895     


Lys Val Arg Gly Gln Asp Leu Gln Gly Arg Arg Phe Glu Asn Leu Gln 
            900                 905                 910         


Lys Arg Leu Val Asn Glu Gln Phe Leu Thr Glu Glu Gln Val Lys Gln 
        915                 920                 925             


Leu Arg Pro Gly Asp Ile Val Pro Asp Asp Ser Gly Glu Leu Phe Met 
    930                 935                 940                 


Thr Leu Thr Asp Gly Ser Gly Ser Lys Glu Val Val Phe Leu Gln Ala 
945                 950                 955                 960 


Asp Ile Asn Ala Ala His Asn Leu Gln Lys Arg Phe Trp Gln Arg Tyr 
                965                 970                 975     


Asn Glu Leu Phe Lys Val Ser Cys Arg Val Ile Val Arg Asp Glu Glu 
            980                 985                 990         


Glu Tyr Leu Val Pro Lys Thr Lys  Ser Val Gln Ala Lys  Leu Gly Lys 
        995                 1000                 1005             


Gly Leu  Phe Val Lys Lys Ser  Asp Thr Ala Trp Lys  Asp Val Tyr 
    1010                 1015                 1020             


Val Trp  Asp Ser Gln Ala Lys  Leu Lys Gly Lys Thr  Thr Phe Thr 
    1025                 1030                 1035             


Glu Glu  Ser Glu Ser Pro Glu  Gln Leu Glu Asp Phe  Gln Glu Ile 
    1040                 1045                 1050             


Ile Glu  Glu Ala Glu Glu Ala  Lys Gly Thr Tyr Arg  Thr Leu Phe 
    1055                 1060                 1065             


Arg Asp  Pro Ser Gly Val Phe  Phe Pro Glu Ser Val  Trp Tyr Pro 
    1070                 1075                 1080             


Gln Lys  Asp Phe Trp Gly Glu  Val Lys Arg Lys Leu  Tyr Gly Lys 
    1085                 1090                 1095             


Leu Arg  Glu Arg Phe Leu Thr  Lys Ala Arg 
    1100                 1105             


<210> 604
<211> 1110
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 604
Met Val Val Arg Ser Ile Lys Leu Lys Met Lys Thr Asn Ser Gly Thr 
1               5                   10                  15      


Asp Ser Ile Tyr Leu Arg Lys Ala Leu Trp Arg Thr His Arg Leu Ile 
            20                  25                  30          


Asn Glu Gly Ile Val Tyr Tyr Met Ser Leu Leu Thr Leu Tyr Arg Gln 
        35                  40                  45              


Asp Thr Leu Gly Asp Arg Thr Lys Glu Glu Ile Gln Ser Glu Leu Ile 
    50                  55                  60                  


Lys Lys Ile Arg Glu Gln Gln Arg Asn Asn Gly Leu Ser Glu Glu Leu 
65                  70                  75                  80  


Gly Ser Asp Gln Glu Ile Leu Ser Leu Leu Arg His Leu Tyr Glu Leu 
                85                  90                  95      


Ile Ile Pro Ser Ile Asn Gly Glu Ser Gly Asp Ala Asn Gln Leu Gly 
            100                 105                 110         


Asn Lys Phe Leu Tyr Pro Leu Val Asp Pro Asn Ser Gln Ser Gly Lys 
        115                 120                 125             


Gly Thr Ser Asn Ala Gly Arg Lys Ser Lys Trp Lys Arg Met Lys Glu 
    130                 135                 140                 


Glu Gly Asn Pro Asp Trp Glu Val Glu Phe Lys Lys Asp Glu Glu Arg 
145                 150                 155                 160 


Lys Ala Asn Asp Pro Thr Ile Lys Val Phe Asp His Leu Lys Lys Tyr 
                165                 170                 175     


Ser Leu Leu Pro Leu Phe Pro Leu Phe Thr Asn Asn Gln Lys Asp Ile 
            180                 185                 190         


Glu Trp Leu Pro Met Gly Lys Arg Gln Ser Val Arg Lys Trp Asp Lys 
        195                 200                 205             


Asp Met Phe Ile Gln Ala Ile Glu Arg Leu Leu Ser Trp Glu Ser Trp 
    210                 215                 220                 


Asn Arg Arg Leu Gly Ala Glu Arg Glu Lys Leu Glu Glu Lys Ile Glu 
225                 230                 235                 240 


Asn Phe Tyr Lys Glu His Leu Ser Gly Gly Gln Ile Trp Ile Glu Lys 
                245                 250                 255     


Ile Arg Glu Phe Glu Arg Val Arg Asp Arg Glu Leu Gly Glu Thr Ser 
            260                 265                 270         


Phe Ser Ser Asn Asp Gly Tyr Leu Ile Thr Ser Arg Gln Ile Arg Gly 
        275                 280                 285             


Trp Asp Arg Val Tyr Glu Lys Trp Ser Lys Ile Ser Glu Ser Ala Ser 
    290                 295                 300                 


Lys Glu Glu Leu Trp Arg Val Val Ala Glu Gln Gln Ser Lys Met Arg 
305                 310                 315                 320 


Glu Gly Phe Gly Asp Pro Lys Val Phe Ser Phe Leu Ala Glu Leu Glu 
                325                 330                 335     


Asn Met Asp Ile Trp Arg Lys His Pro Glu Arg Ile Tyr His Ile Ala 
            340                 345                 350         


Thr Tyr Asn Gly Leu Leu Lys Lys Leu Ser His Thr Lys Ala Gln Ala 
        355                 360                 365             


Thr Phe Thr Leu Pro Asp Ala Val Lys His Pro Leu Trp Ile Arg Tyr 
    370                 375                 380                 


Glu Ala Gln Gly Gly Thr Asn Leu Asn Leu Phe Lys Leu Glu Glu Thr 
385                 390                 395                 400 


Thr Lys Lys Asn Cys Lys Val Ile Leu Ser Lys Ile Ile Trp Pro Thr 
                405                 410                 415     


Glu Asp Gly Trp Phe Glu Lys Glu Asn Val Glu Val Asp Leu Ala Pro 
            420                 425                 430         


Ser Lys Gln Phe Tyr Arg Gln Ile Lys Leu Gln Asp His Ile Lys Gly 
        435                 440                 445             


Lys Gln Glu Ile Ser Phe Ser Asp Tyr Ser Ser Gly Ile Ser Leu Lys 
    450                 455                 460                 


Gly Val Leu Gly Gly Ser Arg Ile Gln Phe Asp Arg Lys Tyr Ile Glu 
465                 470                 475                 480 


Asn His Gln Glu Leu Leu Pro Ser Gly Asp Ile Gly Pro Val Phe Phe 
                485                 490                 495     


Asn Leu Val Ile Asp Leu Leu Pro Ile Gln Glu Thr Arg Asn Gly Arg 
            500                 505                 510         


Leu Lys Ser Pro Ile Gly Lys Thr Leu Lys Val Val Ser Ser Glu Phe 
        515                 520                 525             


Pro Lys Val Ile Asp Tyr Lys Pro Lys Glu Leu Thr Glu Trp Ile Asn 
    530                 535                 540                 


Val Ser Ser Val Thr Gly Lys Val Gly Val Glu Ser Ile Thr Glu Gly 
545                 550                 555                 560 


Met Arg Val Met Ser Ile Asp Leu Gly Gln Arg Thr Ser Ala Ser Val 
                565                 570                 575     


Ser Ile Phe Glu Val Val Lys Glu Leu Pro Lys Asp Lys Glu Lys Met 
            580                 585                 590         


Leu Tyr Tyr Asn Ile Lys Asp Thr Glu Leu Phe Ala Leu His Lys Arg 
        595                 600                 605             


Ser Phe Leu Leu Asn Leu Pro Gly Glu Glu Val Thr Lys Arg Asn Arg 
    610                 615                 620                 


Gln Lys Arg Lys Asp Arg Arg Lys Lys Leu Leu Phe Ile Arg Ser Gln 
625                 630                 635                 640 


Ile Arg Met Leu Ala Ser Val Leu Lys Leu Glu Thr Lys Asn Thr Pro 
                645                 650                 655     


Asp Glu Arg Lys Lys Ala Ile Asn Lys Leu Val Glu Ile Val Asp Ser 
            660                 665                 670         


Tyr Glu Trp Thr Glu Ser Glu Lys Glu Ile Trp Asn Ser Glu Phe Glu 
        675                 680                 685             


Tyr Leu Thr Asn Lys Ala Val Phe Lys Gln Glu Ile Trp Arg Glu Ser 
    690                 695                 700                 


Leu Ile Lys Ser His His Arg Met Glu Pro His Val Gly Gln Leu Val 
705                 710                 715                 720 


Ser Glu Trp Arg Lys Ser Leu Asn Glu Gly Arg Arg Asn Leu Ala Gly 
                725                 730                 735     


Ile Thr Met Trp Asn Ile Glu Glu Leu Glu Asp Thr Arg Arg Leu Leu 
            740                 745                 750         


Ile Ser Trp Ser Lys Arg Ser Arg Thr Pro Gly Glu Ala Asn Arg Ile 
        755                 760                 765             


Asn Asn Asp Glu Pro Phe Gly Ala Lys Leu Leu Glu His Ile Gln Asn 
    770                 775                 780                 


Val Lys Asp Asp Arg Leu Lys Gln Leu Ala Asn Leu Ile Val Met Thr 
785                 790                 795                 800 


Ala Leu Gly Tyr Lys Tyr Asp Lys Glu Glu Lys Ser Arg Asp Lys Arg 
                805                 810                 815     


Trp Lys Glu Lys Tyr Pro Ala Cys Gln Val Ile Leu Phe Glu Asn Leu 
            820                 825                 830         


Asn Arg Tyr Leu Phe Ser Leu Asp Arg Ser Lys Arg Glu Asn Ser Lys 
        835                 840                 845             


Leu Met Lys Trp Ala His Arg Ser Ile Pro Arg Thr Val Trp Met Gln 
    850                 855                 860                 


Gly Glu Met Phe Gly Leu Gln Val Gly Asp Val Arg Ser Glu Tyr Ser 
865                 870                 875                 880 


Ser Arg Phe His Ala Lys Ser Gly Ala Pro Gly Ile Arg Cys His Ser 
                885                 890                 895     


Leu Asn Asp Glu Asp Leu Lys Glu Glu Ser Phe Lys Leu Lys His Leu 
            900                 905                 910         


Ile Glu Thr Gly Phe Ile Ser Glu Glu Glu Ile Ser Ser Leu Lys Lys 
        915                 920                 925             


Gly Asp Ile Val Pro Trp Pro Gly Gly Glu Leu Phe Val Thr Leu Ser 
    930                 935                 940                 


Lys Pro Tyr Lys Lys Gly Lys Asp Ile Glu Leu Thr Val Ile His Ala 
945                 950                 955                 960 


Asp Ile Asn Ala Ala Gln Asn Leu Gln Lys Arg Phe Trp Gln Gln Asn 
                965                 970                 975     


Ser Glu Val Tyr Arg Ile Pro Cys Gln Leu Glu Lys Ala Gly Asp Asp 
            980                 985                 990         


Glu Phe Phe Ile Pro Lys Ser Gln  Thr Glu Ile Val Lys  Lys Tyr Phe 
        995                 1000                 1005             


Gly Lys  Gly Arg Phe Val Lys  Ile Asn Asp Lys Lys  Glu Val Tyr 
    1010                 1015                 1020             


Asn Trp  Glu Glu Ser Glu Lys  Met Lys Ile Lys Thr  Glu Ser Thr 
    1025                 1030                 1035             


Ile Thr  Leu Gln Asp Leu Glu  Gly Phe Glu Asp Ile  Phe Gln Thr 
    1040                 1045                 1050             


Leu Glu  Leu Ala Gln Glu Gln  Gln Lys Lys Tyr Ser  Thr Leu Phe 
    1055                 1060                 1065             


Arg Asp  Pro Ser Gly Tyr Phe  Phe Asn Glu Lys Asn  Trp Arg Pro 
    1070                 1075                 1080             


Gln Lys  Glu Phe Trp Ser Ile  Val Asn Asn Ile Ile  Arg Ser Ser 
    1085                 1090                 1095             


Leu Lys  Lys Lys Ile Leu Lys  Asn Lys Val Glu Val  
    1100                 1105                 1110 


<210> 605
<211> 687
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"


<220>
<221> MOD_RES
<222> (156)..(527)
<223> Any amino acid

<400> 605
Met Ser Asn Pro Asn Ile Pro Asn Ile Ser Pro Asn Ile Thr Leu Thr 
1               5                   10                  15      


Arg Asp Asp Val Val Asn Leu Leu Met Ser Ser Ile Ala Met Glu Glu 
            20                  25                  30          


Leu Gly Leu Ala His Ile Ile Asn Ala Glu Gly Glu Lys Ile Gln Phe 
        35                  40                  45              


Ala Leu Gly Thr Leu Gln Gly Ala Ser Gly Pro Pro Ala Thr Leu Gln 
    50                  55                  60                  


Gln Val Leu Glu Val Asn Gln Ser Thr Gln Ala Met Leu Asp Thr Ile 
65                  70                  75                  80  


Phe Arg Gln Glu Met Met Leu Asp Ser Lys Leu Lys Thr Ala Thr Asn 
                85                  90                  95      


Ile Pro Thr Leu Arg Gly Pro Thr Gly Pro Val Gly Pro Thr Gly Ala 
            100                 105                 110         


Pro Gly Gly Val Ile Ser Ile Asn Gly Gln Thr Gly Val Val Thr Leu 
        115                 120                 125             


Asp Ala Ser Asn Gly Val Met Pro Phe Met Arg Glu Gln Ser Thr Ser 
    130                 135                 140                 


Ser Leu Asp Asp Tyr Lys Asp Pro Gly Ile Tyr Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly 
        515                 520                 525             


Ala Thr Gly Ala Thr Gly Ala Thr Gly Ala Thr Gly Pro Gln Glu Pro 
    530                 535                 540                 


Arg Ala Leu Arg Glu Pro Arg Ala Pro Gln Ala Arg Arg Glu Pro Arg 
545                 550                 555                 560 


Gly Leu Leu Glu Pro Gln Val Leu Arg Gly Pro Gln Glu Pro Arg Ala 
                565                 570                 575     


Leu Arg Glu Pro Arg Ala Pro Arg Ala Leu Arg Glu Pro Arg Ala Leu 
            580                 585                 590         


Arg Ala Leu Arg Ala Leu Gln Glu Leu Arg Ala Pro Arg Ala Leu Arg 
        595                 600                 605             


Gly Leu Gln Glu Pro Arg Val Leu Gln Gly Pro Arg Glu Arg Gln Val 
    610                 615                 620                 


Arg Pro Glu Pro Arg Val Leu Gln Gly Pro Arg Glu Arg Gln Val Arg 
625                 630                 635                 640 


Gln Gly Leu Gln Gly Leu Leu Glu Pro Arg Ala Lys Arg Glu Arg Gln 
                645                 650                 655     


Val Arg Pro Glu Pro Arg Glu Pro Gln Glu Arg Gln Ala Pro Leu Val 
            660                 665                 670         


Gln Gln Ala Leu Leu Glu Pro Gln Ala Leu Leu Gly Gln Ala Leu 
        675                 680                 685         


<210> 606
<211> 1380
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 606
Met Asn Arg Ile Tyr Gln Gly Arg Val Ser Lys Val Glu Ile Pro Asn 
1               5                   10                  15      


Pro Gly Asp Lys Gly Lys Pro Trp Gln Pro Leu Pro Asn Trp Gln Asp 
            20                  25                  30          


Ile Leu Trp Gln His His Glu Leu Phe Gln Asp Ala Val Asn Tyr Tyr 
        35                  40                  45              


Leu Leu Ala Leu Leu Ser Leu Ala Arg Asp Ser Ala Asn Pro Ala Thr 
    50                  55                  60                  


Pro Ile Arg Lys Arg Met Asp Asp Pro Ala Ser Glu His Gln Ile Trp 
65                  70                  75                  80  


Thr Ser Phe Arg Arg Arg Gly Gln Met Arg Ser Gly Met Arg Asp Ser 
                85                  90                  95      


Val Ala Lys Tyr Leu Cys Pro Val Lys Thr Glu Pro Thr Leu Asp Glu 
            100                 105                 110         


Cys Phe Ala Ala Val Leu Glu Gly Asn Lys Glu Asn Pro Asp Val Leu 
        115                 120                 125             


Asp Leu Ala Leu Gln Glu Leu Leu Asp Glu Cys Asp Gly Asp Gly Ala 
    130                 135                 140                 


Ile Gln Gln Glu Gly Arg Ser Met Leu Pro Arg Phe Cys Ser Pro Ser 
145                 150                 155                 160 


Tyr Lys Gly Asp Phe Pro Gln Ser Ala Ala Ala Lys Asp Lys Lys Ser 
                165                 170                 175     


Ala Lys Glu Trp Leu Pro Thr Phe Leu His Ser Ala Glu Asn Ala Ser 
            180                 185                 190         


Asn Leu Lys Leu Val Arg Gln Arg Leu Lys Phe Glu Leu Phe Ala Asn 
        195                 200                 205             


Arg Asp Leu Thr Gly Arg Ile Leu Asp Ala Val Glu Ser Arg Lys Arg 
    210                 215                 220                 


Leu Thr Glu Met Leu Gly Trp Leu Thr Glu Arg Asn Pro Ser Leu Ala 
225                 230                 235                 240 


Ala Glu Arg Glu Arg Leu Gln Lys Ile Ile Ala Ala Leu Pro Asp Thr 
                245                 250                 255     


Phe Asn Leu Pro Ala Trp Arg Gly Gly Ser Val Asn Lys Glu Ala Leu 
            260                 265                 270         


Lys Gln Arg Phe Tyr Ala Trp Leu Ile Phe Glu His Val Glu Ser Ser 
        275                 280                 285             


Arg Ile Thr Phe Asp Ile Leu Arg Asp Ser Phe Pro Thr Pro Lys Glu 
    290                 295                 300                 


Lys Arg Lys Ser Val Ser Glu Thr Ile Gln Ser Glu Lys Pro Ser Leu 
305                 310                 315                 320 


Glu Leu Ser Asp Asp Pro Ile Lys Leu Ala Arg Gly Thr Arg Gly Tyr 
                325                 330                 335     


Val Phe Arg Ala Phe Thr Ser Leu Pro Cys Trp Gly Ala Asp Asn Ala 
            340                 345                 350         


Asn Leu Leu Ala Trp Lys Glu Phe Asp Val Ala Ala Phe Lys Glu Ala 
        355                 360                 365             


Leu Lys Ala Leu His Gln Val Glu Ser Lys Ser Glu Glu Arg Asn Lys 
    370                 375                 380                 


Glu Arg Glu Arg Leu Leu Gln Arg His Ser Val Met Arg Gly Ser Ile 
385                 390                 395                 400 


Lys Trp Lys Pro Ser Pro Glu Ser Glu Glu Lys Glu Pro Asp Val Leu 
                405                 410                 415     


Ala Gly Asp Pro Arg Ile Glu Arg Leu Glu Lys Leu Leu Lys Thr Glu 
            420                 425                 430         


Leu Ala Ser Glu Tyr Glu Met Ser Glu Gly Gln Thr Val Glu Tyr Gly 
        435                 440                 445             


Leu Gln Pro Arg Thr Ile Arg Gly Phe Arg Asp Leu Arg Lys Glu Trp 
    450                 455                 460                 


Asn Lys Ile Val Lys Pro Gly Glu Pro Phe Thr Glu Gln Lys Lys Gly 
465                 470                 475                 480 


Asn Leu Val Thr Ala Leu Arg Ser Tyr Gln Ile Glu Asn Pro Asn Val 
                485                 490                 495     


Ile Gly Ser Val Arg Leu Tyr Glu Ala Leu Leu Glu Lys Gly Asn Trp 
            500                 505                 510         


Leu Val Trp Gln Glu Ala Asp Ser Ala Thr Val Glu Lys Trp Ala Lys 
        515                 520                 525             


Gln Lys Phe Ala Ser Asp Pro Leu Glu Ala Leu Thr Glu Glu Arg Gln 
    530                 535                 540                 


Leu Leu Arg Asp Ile Glu Arg Leu Lys Gln Pro Ile Arg Phe Thr Pro 
545                 550                 555                 560 


Ala Asp Ala Val His Ser Arg Arg Gln Phe Tyr Leu Ala Glu Lys Gly 
                565                 570                 575     


Asp Leu Ser Val Lys Asn Arg Phe Asp Pro Gln Asn Gln Thr Leu Gln 
            580                 585                 590         


Val Pro Ile Ala Ile Lys Asn Asp Asp His Trp Lys Gln Gln Phe Val 
        595                 600                 605             


Lys Ile His Phe Ser Ala Pro Arg Ala Val Arg Asp Gln Leu Ile Asp 
    610                 615                 620                 


Glu Thr Met Glu Glu Ser Lys Glu Ala Arg Trp Gln Gln Pro Met Met 
625                 630                 635                 640 


Glu Ala Leu Gly Leu Ser Leu Lys Leu Thr Lys Asn Asn Ala Glu Val 
                645                 650                 655     


Ser Leu Ser Glu Cys Thr Ala Val Ser Leu Met Pro Glu Glu Leu Ala 
            660                 665                 670         


Ser Gly Asp Arg Arg Ile Leu Leu Asn Phe Pro Ile Thr Leu Glu Thr 
        675                 680                 685             


Ala Pro Met Val Lys Ala Leu Gly Lys Ala Ser Leu Trp Asp Gly Gln 
    690                 695                 700                 


Phe Ala Ala Tyr Gly Asp Asp Asn Phe Tyr Leu Arg Trp Pro Lys Asp 
705                 710                 715                 720 


Lys Trp Pro Ala Glu Lys Glu Ser Asn Ala Trp Tyr Arg Arg Leu Thr 
                725                 730                 735     


Glu Phe Ser Leu Leu Ser Val Asp Leu Gly Gln Arg Asp Ala Gly Ala 
            740                 745                 750         


Phe Ala Val Ile Gly Ala Thr Thr Gly Lys Pro Thr Arg Pro Ala Ser 
        755                 760                 765             


Arg Phe Ile Gly Glu Ala Asn Gly Gln Ser Trp His Ala Ser Val Arg 
    770                 775                 780                 


Ala Thr Gly Val Leu Arg Leu Pro Gly Glu Asp Ala His Val Phe Arg 
785                 790                 795                 800 


Ser Gly Gln Trp Gln Glu Glu Leu Tyr Gly Glu Arg Gly Arg Ser Ala 
                805                 810                 815     


Asp Ala Thr Glu Trp Thr Glu Ala Lys Arg Ile Cys Glu Thr Leu Gly 
            820                 825                 830         


Leu Lys Phe Asp Glu Ile Leu Gly Gly Asp Pro Gln Trp Phe Ser Phe 
        835                 840                 845             


Pro Glu Leu Asn Asp Arg Leu Leu Phe Ala Val Arg Arg Ala Gln Thr 
    850                 855                 860                 


Arg Leu Ala Arg Leu Gln Ser Trp Ser Trp Met Ile Ala Asp Glu Thr 
865                 870                 875                 880 


Arg Arg Glu Asn Ile Arg Glu Ala Ile Leu Ala Ala Asp Asp Asp Glu 
                885                 890                 895     


Leu Ser Leu Lys Ala Ala Ala Glu Lys Ser Leu Trp Pro Val Leu Ala 
            900                 905                 910         


Glu Lys Leu Ala Ser Glu Val Asn Arg Leu Arg Asn Leu Ile Pro Gln 
        915                 920                 925             


Gln Leu Val Leu Leu Ala Asn Arg Ile Leu Pro Leu Arg Gly Arg Arg 
    930                 935                 940                 


Trp Glu Trp Ile Lys Arg Asp Asp Thr Ser Gly Cys His Val Leu Arg 
945                 950                 955                 960 


Glu Thr Asn Pro Gly Thr Asp Thr Thr Ser Lys Lys Val Cys Gly Gln 
                965                 970                 975     


Arg Gly Leu Ser Met Lys Arg Leu Glu Gln Leu Asp Glu Leu Arg Arg 
            980                 985                 990         


Arg Phe Gln Ser Leu Asn Arg Ala  Leu Met Gln Thr Pro  Gly Gln Thr 
        995                 1000                 1005             


Ala Gly  Leu Gly Lys Ser Lys  Arg Gly Ile Glu Leu  Pro Asp Pro 
    1010                 1015                 1020             


Cys Pro  Asp Leu Leu Asp Lys  Thr Glu Gln Leu Arg  Glu Gln Arg 
    1025                 1030                 1035             


Val Asn  Gln Thr Ala His Leu  Ile Leu Ala Gln Ala  Leu Gly Val 
    1040                 1045                 1050             


Arg Leu  Arg Thr Pro Gln Lys  Gly Asp Ala Leu Arg  Glu Gln Asn 
    1055                 1060                 1065             


Asn Val  His Gly Glu Tyr Glu  Thr Phe Arg Leu Pro  Val Asp Phe 
    1070                 1075                 1080             


Ile Val  Leu Glu Asp Leu Ser  Arg Tyr Leu Ser Ser  Gln Gly Arg 
    1085                 1090                 1095             


Gly Arg  Asn Glu Asn Ser Arg  Leu Met Lys Trp Cys  His Arg Ala 
    1100                 1105                 1110             


Ile Leu  Leu Lys Leu Lys Gln  Leu Cys Glu Ser Tyr  Gly Leu Lys 
    1115                 1120                 1125             


Ile Leu  Glu Thr Asn Ala Ala  Tyr Ser Ser Arg Phe  Cys Ser Arg 
    1130                 1135                 1140             


Thr Gly  Val Ala Gly Phe Arg  Ala Val Glu Leu Thr  Pro Asp Ala 
    1145                 1150                 1155             


Arg Lys  Glu Phe Arg Trp Arg  Lys His Leu Asn Arg  Leu Glu Lys 
    1160                 1165                 1170             


Ala Ala  Ser Gly Glu Ile Lys  Leu Asp Arg Glu Ala  Arg Ala Glu 
    1175                 1180                 1185             


Ser Glu  His Val Lys Arg Leu  Phe Asp Met Leu Asp  Gln Leu Asn 
    1190                 1195                 1200             


Ala Gly  Arg Lys Glu Ala Gly  Lys Pro Leu Arg Thr  Leu Leu Ala 
    1205                 1210                 1215             


Pro Ile  Ala Gly Gly Gln Ile  Phe Ile Pro Met Gln  Gly His Ala 
    1220                 1225                 1230             


Thr Gln  Ala Asp Ile Asn Ala  Ala Ile Asn Leu Gly  Leu Arg Ala 
    1235                 1240                 1245             


Ile Ala  Ala Pro Asp Cys His  Ala Ile His Val Arg  Ile Arg Thr 
    1250                 1255                 1260             


Glu Arg  Lys Asp Lys Thr Leu  Arg Val Arg Thr Gly  Ser Asn Arg 
    1265                 1270                 1275             


Glu Lys  Val Arg Trp Glu Gly  Lys Asn Pro Glu Ile  Gln Met Asn 
    1280                 1285                 1290             


Lys Ala  Ala Asp Leu Ala Ser  Leu Thr Gly Asp Arg  Gln Pro Asn 
    1295                 1300                 1305             


Phe Phe  Pro Asp Pro Ser Ala  Ile Ala Cys Tyr Asp  Arg Ala Lys 
    1310                 1315                 1320             


Ile Glu  Gly Val Gln Leu Pro  Phe Ala Ser Gly Arg  Gly Leu Trp 
    1325                 1330                 1335             


Gly Thr  Met Asn Ile Glu Leu  Gln Trp Thr Arg Val  Asn Gln Leu 
    1340                 1345                 1350             


Asn Asn  Asp Arg Ala Glu Lys  Lys Trp Asn Leu Thr  Arg Ser Leu 
    1355                 1360                 1365             


Pro Glu  Gln Ser Ser Glu Glu  Asp Tyr Ile Pro Met  
    1370                 1375                 1380 


<210> 607
<211> 1144
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 607
Met Ala Val Lys Ser Ile Lys Val Lys Leu Met Leu Gly His Leu Pro 
1               5                   10                  15      


Glu Ile Arg Glu Gly Leu Trp His Leu His Glu Ala Val Asn Leu Gly 
            20                  25                  30          


Val Arg Tyr Tyr Thr Glu Trp Leu Ala Leu Leu Arg Gln Gly Asn Leu 
        35                  40                  45              


Tyr Arg Arg Gly Lys Asp Gly Ala Gln Glu Cys Tyr Met Thr Ala Glu 
    50                  55                  60                  


Gln Cys Arg Gln Glu Leu Leu Val Arg Leu Arg Asp Arg Gln Lys Arg 
65                  70                  75                  80  


Asn Gly His Thr Gly Asp Pro Gly Thr Asp Glu Glu Leu Leu Gly Val 
                85                  90                  95      


Ala Arg Arg Leu Tyr Glu Leu Leu Val Pro Gln Ser Val Gly Lys Lys 
            100                 105                 110         


Gly Gln Ala Gln Met Leu Ala Ser Gly Phe Leu Ser Pro Leu Ala Asp 
        115                 120                 125             


Pro Lys Ser Glu Gly Gly Lys Gly Thr Ser Lys Ser Gly Arg Lys Pro 
    130                 135                 140                 


Ala Trp Met Gly Met Lys Glu Ala Gly Asp Ser Arg Trp Val Glu Ala 
145                 150                 155                 160 


Lys Ala Arg Tyr Glu Ala Asn Lys Ala Lys Asp Pro Thr Lys Gln Val 
                165                 170                 175     


Ile Ala Ser Leu Glu Met Tyr Gly Leu Arg Pro Leu Phe Asp Val Phe 
            180                 185                 190         


Thr Glu Thr Tyr Lys Thr Ile Arg Trp Met Pro Leu Gly Lys His Gln 
        195                 200                 205             


Gly Val Arg Ala Trp Asp Arg Asp Met Phe Gln Gln Ser Leu Glu Arg 
    210                 215                 220                 


Leu Met Ser Trp Glu Ser Trp Asn Glu Arg Val Gly Ala Glu Phe Ala 
225                 230                 235                 240 


Arg Leu Val Asp Arg Arg Asp Arg Phe Arg Glu Lys His Phe Thr Gly 
                245                 250                 255     


Gln Glu His Leu Val Ala Leu Ala Gln Arg Leu Glu Gln Glu Met Lys 
            260                 265                 270         


Glu Ala Ser Pro Gly Phe Glu Ser Lys Ser Ser Gln Ala His Arg Ile 
        275                 280                 285             


Thr Lys Arg Ala Leu Arg Gly Ala Asp Gly Ile Ile Asp Asp Trp Leu 
    290                 295                 300                 


Lys Leu Ser Glu Gly Glu Pro Val Asp Arg Phe Asp Glu Ile Leu Arg 
305                 310                 315                 320 


Lys Arg Gln Ala Gln Asn Pro Arg Arg Phe Gly Ser His Asp Leu Phe 
                325                 330                 335     


Leu Lys Leu Ala Glu Pro Val Phe Gln Pro Leu Trp Arg Glu Asp Pro 
            340                 345                 350         


Ser Phe Leu Ser Arg Trp Ala Ser Tyr Asn Glu Val Leu Asn Lys Leu 
        355                 360                 365             


Glu Asp Ala Lys Gln Phe Ala Thr Phe Thr Leu Pro Ser Pro Cys Ser 
    370                 375                 380                 


Asn Pro Val Trp Ala Arg Phe Glu Asn Ala Glu Gly Thr Asn Ile Phe 
385                 390                 395                 400 


Lys Tyr Asp Phe Leu Phe Asp His Phe Gly Lys Gly Arg His Gly Val 
                405                 410                 415     


Arg Phe Gln Arg Met Ile Val Met Arg Asp Gly Val Pro Thr Glu Val 
            420                 425                 430         


Glu Gly Ile Val Val Pro Ile Ala Pro Ser Arg Gln Leu Asp Ala Leu 
        435                 440                 445             


Ala Pro Asn Asp Ala Ala Ser Pro Ile Asp Val Phe Val Gly Asp Pro 
    450                 455                 460                 


Ala Ala Pro Gly Ala Phe Arg Gly Gln Phe Gly Gly Ala Lys Ile Gln 
465                 470                 475                 480 


Tyr Arg Arg Ser Ala Leu Val Arg Lys Gly Arg Arg Glu Glu Lys Ala 
                485                 490                 495     


Tyr Leu Cys Gly Phe Arg Leu Pro Ser Gln Arg Arg Thr Gly Thr Pro 
            500                 505                 510         


Ala Asp Asp Ala Gly Glu Val Phe Leu Asn Leu Ser Leu Arg Val Glu 
        515                 520                 525             


Ser Gln Ser Glu Gln Ala Gly Arg Arg Asn Pro Pro Tyr Ala Ala Val 
    530                 535                 540                 


Phe His Ile Ser Asp Gln Thr Arg Arg Val Ile Val Arg Tyr Gly Glu 
545                 550                 555                 560 


Ile Glu Arg Tyr Leu Ala Glu His Pro Asp Thr Gly Ile Pro Gly Ser 
                565                 570                 575     


Arg Gly Leu Thr Ser Gly Leu Arg Val Met Ser Val Asp Leu Gly Leu 
            580                 585                 590         


Arg Thr Ser Ala Ala Ile Ser Val Phe Arg Val Ala His Arg Asp Glu 
        595                 600                 605             


Leu Thr Pro Asp Ala His Gly Arg Gln Pro Phe Phe Phe Pro Ile His 
    610                 615                 620                 


Gly Met Asp His Leu Val Ala Leu His Glu Arg Ser His Leu Ile Arg 
625                 630                 635                 640 


Leu Pro Gly Glu Thr Glu Ser Lys Lys Val Arg Ser Ile Arg Glu Gln 
                645                 650                 655     


Arg Leu Asp Arg Leu Asn Arg Leu Arg Ser Gln Met Ala Ser Leu Arg 
            660                 665                 670         


Leu Leu Val Arg Thr Gly Val Leu Asp Glu Gln Lys Arg Asp Arg Asn 
        675                 680                 685             


Trp Glu Arg Leu Gln Ser Ser Met Glu Arg Gly Gly Glu Arg Met Pro 
    690                 695                 700                 


Ser Asp Trp Trp Asp Leu Phe Gln Ala Gln Val Arg Tyr Leu Ala Gln 
705                 710                 715                 720 


His Arg Asp Ala Ser Gly Glu Ala Trp Gly Arg Met Val Gln Ala Ala 
                725                 730                 735     


Val Arg Thr Leu Trp Arg Gln Leu Ala Lys Gln Val Arg Asp Trp Arg 
            740                 745                 750         


Lys Glu Val Arg Arg Asn Ala Asp Lys Val Lys Ile Arg Gly Ile Ala 
        755                 760                 765             


Arg Asp Val Pro Gly Gly His Ser Leu Ala Gln Leu Asp Tyr Leu Glu 
    770                 775                 780                 


Arg Gln Tyr Arg Phe Leu Arg Ser Trp Ser Ala Phe Ser Val Gln Ala 
785                 790                 795                 800 


Gly Gln Val Val Arg Ala Glu Arg Asp Ser Arg Phe Ala Val Ala Leu 
                805                 810                 815     


Arg Glu His Ile Asp Asn Gly Lys Lys Asp Arg Leu Lys Lys Leu Ala 
            820                 825                 830         


Asp Arg Ile Leu Met Glu Ala Leu Gly Tyr Val Tyr Val Thr Asp Gly 
        835                 840                 845             


Arg Arg Ala Gly Gln Trp Gln Ala Val Tyr Pro Pro Cys Gln Leu Val 
    850                 855                 860                 


Leu Leu Glu Glu Leu Ser Glu Tyr Arg Phe Ser Asn Asp Arg Pro Pro 
865                 870                 875                 880 


Ser Glu Asn Ser Gln Leu Met Val Trp Ser His Arg Gly Val Leu Glu 
                885                 890                 895     


Glu Leu Ile His Gln Ala Gln Val His Asp Val Leu Val Gly Thr Ile 
            900                 905                 910         


Pro Ala Ala Phe Ser Ser Arg Phe Asp Ala Arg Thr Gly Ala Pro Gly 
        915                 920                 925             


Ile Arg Cys Arg Arg Val Pro Ser Ile Pro Leu Lys Asp Ala Pro Ser 
    930                 935                 940                 


Ile Pro Ile Trp Leu Ser His Tyr Leu Lys Gln Thr Glu Arg Asp Ala 
945                 950                 955                 960 


Ala Ala Leu Arg Pro Gly Glu Leu Ile Pro Thr Gly Asp Gly Glu Phe 
                965                 970                 975     


Leu Val Thr Pro Ala Gly Arg Gly Ala Ser Gly Val Arg Val Val His 
            980                 985                 990         


Ala Asp Ile Asn Ala Ala His Asn  Leu Gln Arg Arg Leu  Trp Glu Asn 
        995                 1000                 1005             


Phe Asp  Leu Ser Asp Ile Arg  Val Arg Cys Asp Arg  Arg Glu Gly 
    1010                 1015                 1020             


Lys Asp  Gly Thr Val Val Leu  Ile Pro Arg Leu Thr  Asn Gln Arg 
    1025                 1030                 1035             


Val Lys  Glu Arg Tyr Ser Gly  Val Ile Phe Thr Ser  Glu Asp Gly 
    1040                 1045                 1050             


Val Ser  Phe Thr Val Gly Asp  Ala Lys Thr Arg Arg  Arg Ser Ser 
    1055                 1060                 1065             


Ala Ser  Gln Gly Glu Gly Asp  Asp Leu Ser Asp Glu  Glu Gln Glu 
    1070                 1075                 1080             


Leu Leu  Ala Glu Ala Asp Asp  Ala Arg Glu Arg Ser  Val Val Leu 
    1085                 1090                 1095             


Phe Arg  Asp Pro Ser Gly Phe  Val Asn Gly Gly Arg  Trp Thr Ala 
    1100                 1105                 1110             


Gln Arg  Ala Phe Trp Gly Met  Val His Asn Arg Ile  Glu Thr Leu 
    1115                 1120                 1125             


Leu Ala  Glu Arg Phe Ser Val  Ser Gly Ala Ala Glu  Lys Val Arg 
    1130                 1135                 1140             


Gly 
    


<210> 608
<211> 647
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"


<220>
<221> MOD_RES
<222> (35)..(498)
<223> Any amino acid

<400> 608
Met Gly Leu Val Asp Thr Ala Gly Gly Phe Leu Ile Pro Ala Ala Leu 
1               5                   10                  15      


Asp Pro Ala Ile Leu Leu Ser Gly Asp Gly Ser Thr Asn Pro Ile Arg 
            20                  25                  30          


Gln Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Pro Ser Arg Cys Arg Cys Leu Ala Phe Gly Arg Ser Ser Ser 
            500                 505                 510         


Ala Ile Arg Arg Pro Ala Ala Ser Ser Ser Glu Gly Val Lys Ser Leu 
        515                 520                 525             


Arg Ser Val Phe Ser Glu Arg Ser Ala Leu Ala Arg Ser Thr Thr Ser 
    530                 535                 540                 


Ala Ile Val Trp His Thr Cys Thr Gly Met Arg Ser His Pro Ser Ser 
545                 550                 555                 560 


Arg Ala Ala Ser Ser Arg Arg Trp Pro Asn Thr Ser Arg Leu Ser Gly 
                565                 570                 575     


Val Thr Pro Ile Gly Cys Ser Lys Arg Gln Gly Asp Ser Pro Cys Gly 
            580                 585                 590         


Cys Cys Cys Gly Ala His Leu Val Val Ala Gln Arg Cys Val Ala Phe 
        595                 600                 605             


Cys Cys His Asp Arg Gly Val Thr Glu Lys Leu Leu Tyr Ser Ser Gln 
    610                 615                 620                 


Val Val Gly Ala Ala Val Gly Ala Gly Gly Val Ser Val Pro Gln Gly 
625                 630                 635                 640 


Val His Gly Arg Val Thr Gly 
                645         


<210> 609
<211> 1262
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 609
Met Arg Arg Gln His His Gly Gly Gln Asn Ala Arg Asp Trp Arg Arg 
1               5                   10                  15      


Lys Val Ala Ala Ala Ala Leu Arg Gln Lys Glu Ser Val Phe Thr Tyr 
            20                  25                  30          


Lys Phe Gly Leu Ser Val Asn Asp Gly Asp Phe Asp Phe Asp Ala Ala 
        35                  40                  45              


Ala Arg Thr Tyr Asp Ile Thr Glu Gly Ile Glu Arg Gly Ser Leu Ile 
    50                  55                  60                  


Gly Leu Val Cys Ala Val His Leu Ser Gly Phe Arg Leu Phe Ser Lys 
65                  70                  75                  80  


Val Ala Glu Thr Arg Gln Phe Leu Asn Arg Ser Arg Tyr Pro Glu Asn 
                85                  90                  95      


Glu Phe Ala Gln Ala Leu Ala Ala His Thr Glu Ile Glu Asn Pro Ser 
            100                 105                 110         


Val Thr Val Gln Ser Ile Glu Ser Val Phe Val Thr Pro Pro Arg Lys 
        115                 120                 125             


Gln Asp Gly Val Ala Arg Leu Trp Ser Ala Asp Glu Leu Ala Lys Arg 
    130                 135                 140                 


Leu Phe Gln Thr Trp Asn Asn Arg Ser Pro Arg Glu Gly Glu Arg Asn 
145                 150                 155                 160 


His Pro Glu Leu Leu Leu Ala Gln Gly Ile Ala Arg Ala Val Thr Lys 
                165                 170                 175     


Ala Phe Ser Gly Trp Lys Glu Leu Ala Asp Asn Ala Val His Ala Leu 
            180                 185                 190         


Thr Cys Ala Asp Asn Tyr Leu Ala Thr Leu Gly Asn Arg Phe Pro Lys 
        195                 200                 205             


Leu Ser Asp Leu Pro Pro Leu Thr Ala Gly Ser Thr Gln Thr Gly Thr 
    210                 215                 220                 


Leu Ala Phe Asp Pro Glu Ser Pro Phe Leu Asn Met Thr Gly Asn Glu 
225                 230                 235                 240 


Asp Ile Trp Leu His Gln Val Val Ala Val Cys Ala Gly Arg Leu Lys 
                245                 250                 255     


Arg Tyr Met Pro Glu Ile Asp Pro Ser Ser Arg Lys Phe Ala Ser Arg 
            260                 265                 270         


Leu Thr Asp Ser Ile Val Ser Ser Gln Asn Asn Gly Leu Ser Trp Leu 
        275                 280                 285             


Phe Gly Asn Gly Leu Arg Phe Leu Arg Gln Ser Ser Ile Ala Gln Ile 
    290                 295                 300                 


Ala Glu Thr Leu Ser Val Ser Gln Asn Glu His Arg Arg Val Glu Gln 
305                 310                 315                 320 


Leu Lys Glu Phe Ala Asp Ala Ile Pro Val Asn Pro Phe Phe Ala Thr 
                325                 330                 335     


Asp Gly Tyr Ala Glu Phe Arg Gly Ser Val Gly Gly Lys Ile Ser Ser 
            340                 345                 350         


Trp Val Ser Asn Tyr Trp Lys Arg Ile Cys Glu Leu Thr Val Leu His 
        355                 360                 365             


Ser Gln Pro Pro Asp Ile Thr Ile Pro Glu Gly Leu Leu Ala Ser Glu 
    370                 375                 380                 


Asn Ala Thr Leu Phe Ser Gly Gln His Thr Ala Ala Ala Gly Leu Val 
385                 390                 395                 400 


Ala Leu Ser Ala Arg Leu Pro Ser Gln Val Arg Asp Ala Gly Lys Ala 
                405                 410                 415     


Leu Phe Val Leu Ser Gly Asp Gly Val Pro Arg Ala Asp Asp Ile Ala 
            420                 425                 430         


Thr Val Glu Asp Val Ala Gly Glu Leu Ala Glu Leu Thr Gly Gln Leu 
        435                 440                 445             


Ala Met Leu Asp Asn Arg Ile Gln Gln Glu Ile Glu Arg Ala Gln Asp 
    450                 455                 460                 


Ala Asn Asp Glu Gly Arg Val Gly Ser Leu Ala Ser Leu Arg Pro Asn 
465                 470                 475                 480 


Pro Thr Lys Glu Leu Lys Glu Pro Pro Lys Leu Asn Arg Ile Ser Gly 
                485                 490                 495     


Gly Thr Ala Asp Ala Ala Gly Glu Leu Ala Arg Leu Glu Thr Ser Leu 
            500                 505                 510         


Asn Asp Leu Ile Arg Ala Arg Arg Glu His Phe Tyr Arg Leu Ala Glu 
        515                 520                 525             


Trp Thr Gly Asn Thr Ala Ser Leu Asp Pro Leu Pro Ala Leu Ala Glu 
    530                 535                 540                 


Arg Glu Arg Lys Ala Leu Thr Asp Arg Gly Met Asp Pro Thr Leu Ala 
545                 550                 555                 560 


Glu Ala Asp Glu Tyr Ala Leu Arg Arg Leu Leu His Arg Ile Ala Gly 
                565                 570                 575     


Met Ala Arg Arg Leu Ser Pro Asn Glu Ala Lys Arg Val Arg Glu Thr 
            580                 585                 590         


Met Thr Pro Leu Phe Leu Lys Lys Arg Glu Ala Asn Leu Tyr Phe His 
        595                 600                 605             


Asn Arg Ala Gly Ala Leu Tyr Arg His Pro Phe Ser Asn Ser Arg His 
    610                 615                 620                 


Gln Pro Tyr Ser Ile Asp Leu Asn Arg Ala Arg Ala Thr Asp Trp Leu 
625                 630                 635                 640 


Ala Trp Leu Glu Glu Arg Ala Arg Glu Met Leu Gly Leu Leu Gly Ser 
                645                 650                 655     


Gly Ala Pro Ala Asn His Glu Tyr Leu Arg Asp Leu Leu Ser Ile Glu 
            660                 665                 670         


Thr Phe Val Phe Thr Thr Arg Leu Ser Gly Leu Pro Ala Gln Val Pro 
        675                 680                 685             


Gly Tyr Leu Ala Lys Pro Lys Ser Asp Leu Thr Asn Ile Pro Pro Leu 
    690                 695                 700                 


Leu Ala Ala Gln Leu Asp Val Asp Glu Val Ser Arg Asp Val Ala Leu 
705                 710                 715                 720 


Arg Ala Phe Asn Leu Phe Asn Ser Ala Ile Asn Gly Leu Ser Phe Arg 
                725                 730                 735     


Ala Phe Arg Asp Ser Phe Ile Val Arg Thr Lys Phe Leu Arg Leu Gly 
            740                 745                 750         


His Asp Glu Leu Phe Tyr Val Pro Lys Ala Arg Ala Trp Lys Pro Pro 
        755                 760                 765             


Ala Asp Tyr Arg Ser Ala Lys Gly Lys Ile Ser Lys Gly Leu Ala Leu 
    770                 775                 780                 


Pro Ala Val Lys Arg Asn Glu Ala Gly Ser Ile Leu Pro Arg Glu Thr 
785                 790                 795                 800 


Thr Gln Gly Leu Ser Arg Ala Lys Phe Pro Glu Gly Ser His Ala Leu 
                805                 810                 815     


Leu Ser Gln Ala Pro His Asp Trp Phe Val Glu Leu Asp Leu Arg His 
            820                 825                 830         


Asp Lys Met Pro Gln Leu Ala Gly Leu Pro Val Lys Met Asn Ala Asp 
        835                 840                 845             


Gly Leu Lys Gly Trp Arg Ala Arg Arg Arg Pro Thr Phe Arg Leu Ala 
    850                 855                 860                 


Gly Pro Pro Ser Phe Lys Thr Trp Leu Asp Arg Ala Leu Thr Ser Thr 
865                 870                 875                 880 


Ala Val Lys Leu Gly Asp Tyr Thr Leu Ile Leu Asp Gln Ser Phe Lys 
                885                 890                 895     


Gln Ser Leu Arg Val Glu Asp Gly Glu Val Arg Leu Ser Ala Glu Pro 
            900                 905                 910         


Ala Gly Ile Lys Ala Glu Ile Ala Val Pro Val Ile Asp Ala Arg Pro 
        915                 920                 925             


Phe Pro Glu Thr Glu Ala Glu Ala Leu Phe Asp Asn Ile Ile Gly Ile 
    930                 935                 940                 


Asp Leu Gly Glu Arg Arg Ile Gly Tyr Ala Val Phe Ser Leu Pro Ala 
945                 950                 955                 960 


Leu Leu Lys Ser Gly Asn Pro Thr Arg Val Lys Pro Thr Val Val Gly 
                965                 970                 975     


Ser Val Ala Ile Pro Ala Phe Arg Arg Leu Met Ala Ala Val Arg Arg 
            980                 985                 990         


His Arg Gly Ser Arg Gln Pro Asn  Gln Lys Val Ser Gln  Thr Tyr Ser 
        995                 1000                 1005             


Thr Ala  Leu Gln Gln Phe Arg  Glu Asn Val Val Gly  Asp Val Cys 
    1010                 1015                 1020             


Asn Arg  Ile Asp Thr Leu Cys  Glu Arg Tyr Arg Ala  Phe Pro Val 
    1025                 1030                 1035             


Leu Glu  Ser Ser Val Ala Asn  Phe Glu Thr Gly Ala  Asn Gln Leu 
    1040                 1045                 1050             


Lys Leu  Ile Tyr Gly Thr Val  Leu Arg Arg Tyr Thr  Phe Ser Asn 
    1055                 1060                 1065             


Val Asp  Ala His Lys Ser Ala  Arg Ser Ala Tyr Trp  Tyr Ser Ala 
    1070                 1075                 1080             


Asn Arg  Trp Gln His Pro Tyr  Leu Phe Val Arg Glu  Trp Asn Lys 
    1085                 1090                 1095             


Ala Gln  Arg Thr Phe Thr Gly  Ser Ala Lys Pro Leu  Ala Ile Tyr 
    1100                 1105                 1110             


Pro Gly  Val Thr Ile His Pro  Ala Gly Thr Ser Gln  Ile Cys His 
    1115                 1120                 1125             


Arg Cys  Gly Arg Asn Ala Leu  Arg Ala Leu Arg Asn  Met Pro Asp 
    1130                 1135                 1140             


Arg Thr  Ile Arg Val Gly Lys  Asp Gly Leu Ile Val  Leu Ala Asp 
    1145                 1150                 1155             


Ser Thr  Ile Arg Leu Leu Glu  Arg Ala Asp Tyr Ser  Asp Arg Glu 
    1160                 1165                 1170             


Leu Lys  Thr Phe Lys Arg Arg  Lys Gln Arg Pro Pro  Leu Asn Met 
    1175                 1180                 1185             


Pro Val  Pro Glu Gly Ala Arg  Pro Arg Asp Gln Leu  Glu Arg Val 
    1190                 1195                 1200             


Leu Arg  Arg Asn Met Arg Gln  Gln Pro Gln Ser Glu  Met Ser Pro 
    1205                 1210                 1215             


Asp Thr  Thr Gln Ala Arg Phe  Thr Cys Val Tyr Thr  Asp Cys Gly 
    1220                 1225                 1230             


Phe Glu  Gly His Ala Asp Glu  Asn Ala Ala Val Asn  Ile Gly Arg 
    1235                 1240                 1245             


Arg Phe  Leu Glu Arg Ile Asp  Ile Glu Ala Ser Ser  Arg Thr 
    1250                 1255                 1260         


<210> 610
<211> 978
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 610
Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210> 611
<211> 1488
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 611
Met Gly Lys Gln Ser Thr Asn Ser Ser Gly Leu Lys Ala Thr Ser Gly 
1               5                   10                  15      


Ala Pro Ser Ile Glu Lys Pro Val Thr Thr Gln Arg Ala Tyr Thr Leu 
            20                  25                  30          


Arg Leu Arg Gly Ile Glu Gly Asp Lys Thr Trp Arg Asp Ser Leu Trp 
        35                  40                  45              


Ala Thr His Glu Ala Ile Asn Leu Gly Ala Lys Ala Phe Gly Asp Trp 
    50                  55                  60                  


Leu Leu Thr Leu Arg Gly Gly Leu Glu His Thr Leu Ala Asp Ala Thr 
65                  70                  75                  80  


Val Ala Gly Gly Lys Gly Lys Pro Ala Arg Pro Pro Ser Ala Asp Glu 
                85                  90                  95      


Arg Arg Asp Arg Arg Val Leu Leu Ala Leu Ser Trp Leu Thr Val Glu 
            100                 105                 110         


Asp Glu Arg Gly Ala Pro Lys Ala Pro Gly Leu Ile Val Ala Tyr Gly 
        115                 120                 125             


Asp Asp Cys Lys Ser Ala Lys Asp Ser Gln Asp Gly Arg Asp Arg Lys 
    130                 135                 140                 


Val Glu Asp Ala Leu Arg Asp Ile Leu Ile Lys Arg Ser Val Ala Pro 
145                 150                 155                 160 


Gly Ala Val Glu Ser Trp Val Asn Asp Cys Val Val Ser Leu Lys Ala 
                165                 170                 175     


Arg Ile Arg Asp Asp Ala Val Trp Val Asn Arg Ser Ala Ala Phe Asp 
            180                 185                 190         


Ala Leu Arg Ala Ser Trp Arg Gly Leu Thr Cys Pro Asn Ala Arg Thr 
        195                 200                 205             


Val Leu Glu Gln Phe Phe Gly Pro Val Ala Asp Trp Ile Thr Leu Pro 
    210                 215                 220                 


Ala Arg Ala Ala Asp Asp Gly Glu Gly Asp Thr Gly Gly Pro Thr Ala 
225                 230                 235                 240 


Ala Gly Ser Ser Asn Asp Thr Glu Phe Lys Leu Val Ala Arg Ser Phe 
                245                 250                 255     


Leu Ser Glu Asn Phe Gly Thr Gly Leu Lys Ser Ser Lys Ser Asp Ile 
            260                 265                 270         


Ser Asp Ala Leu Met Gln Ala Thr Arg Ser Leu Ala Ala Leu Arg Gly 
        275                 280                 285             


Gly Ser Pro Gly Ser Ala Val Trp Ser His Leu Cys Thr Glu Phe Gly 
    290                 295                 300                 


Leu Leu Ala Ala Asp Asp Glu Ala Arg Ala Lys Ala Leu Arg Val Arg 
305                 310                 315                 320 


Ile Gly Trp Thr Ser Gly Arg Arg Ser Lys Gly Arg Leu Ala Leu Ala 
                325                 330                 335     


Thr Ala Ala Ser Lys Ala Ser Leu Ala Gln Val Asp Ile Glu Leu Leu 
            340                 345                 350         


Ile Lys Lys Leu Ser Glu Glu Ala Gln Glu Lys Leu Ala Gly Ser Thr 
        355                 360                 365             


Lys Leu Pro Leu Pro Trp Val Asn Asp Leu Met Ala Ala Leu Glu Arg 
    370                 375                 380                 


Ser Ile Gly Phe Gly Phe Val Thr Glu Arg Asn Leu Ile Asp Glu Phe 
385                 390                 395                 400 


Gly Val Met Leu Asp His Ala Ala Arg Arg Val Ser Ile Ala Cys Ser 
                405                 410                 415     


Trp Ile Lys Leu Ala Glu Leu Glu Arg Arg Gln Phe Glu Glu Asp Ala 
            420                 425                 430         


Lys Lys Leu Asp Gln Val Arg Thr Gln His Ala Asp Ala Ala Ala Phe 
        435                 440                 445             


Leu Asp Thr Leu Gly Cys Arg Arg Gly Ser Glu Ser Gly Ser Ala Gly 
    450                 455                 460                 


Gly Ala Ser Val Val Ile Arg Lys Arg Ala Val Leu Gly Trp Asn Glu 
465                 470                 475                 480 


Val Val Gly Asp Trp Ala Arg Gln Gly Cys Lys Ser Val Gln Glu Arg 
                485                 490                 495     


Ile Asp Ala Ala Arg Leu Leu Gln Gly Glu Leu Glu Lys Phe Gly Asp 
            500                 505                 510         


Ile Arg Leu Phe Glu Glu Leu Ala Ala Asn Asp Ala Gln Val Val Trp 
        515                 520                 525             


Gln Asn Ala Glu Gly Glu Thr Asp Pro Thr Ile Leu Ala Arg Tyr Ser 
    530                 535                 540                 


Ala Gly Ser Val Ala Lys Ala Asn Gln Gln Arg Phe Lys Val Pro Ala 
545                 550                 555                 560 


Tyr Arg His Pro Asp Pro Leu Arg His Pro Val Phe Gly Asp Phe Gly 
                565                 570                 575     


Lys Ser Arg Trp Lys Ile Asp Phe Ala Val His Glu Ser Asp Arg Ala 
            580                 585                 590         


Gln Ser Gly Gly Lys Arg Val Arg Ser Leu Asp Ala Ala Trp Gln Ser 
        595                 600                 605             


Asp Val Arg Asn Met Arg Met Ala Leu Trp Thr Gly Lys Arg Val Glu 
    610                 615                 620                 


Met Val Pro Leu Arg Trp Ser Ser Lys Arg Leu Ser Lys Asp Leu Gly 
625                 630                 635                 640 


Ile Ser Asp Leu Ser Leu Lys Asp Pro Thr Val Val Thr Arg Gly Asp 
                645                 650                 655     


Arg Leu Gly Arg Ala Ala Val Gly Pro Gly Asp Pro Val Arg Val Ala 
            660                 665                 670         


Ser Val Phe Ala Glu Asp Asn Trp Asn Gly Arg Leu Gln Ala Pro Arg 
        675                 680                 685             


Val Glu Leu Asn Arg Val Ala Arg Leu Thr Gln Ser Gly Asn Leu Val 
    690                 695                 700                 


Gln Ala Arg Arg Leu Arg Asp Arg Leu Ser Trp Leu Val Ser Phe Ser 
705                 710                 715                 720 


Pro Lys Leu Ala Pro Ser Gly Pro Phe Ile Asp Tyr Ala Ala Ala His 
                725                 730                 735     


Gly Ile Glu Pro His Lys Lys Ser Gly Glu Tyr Trp Pro Asn Ser Ala 
            740                 745                 750         


Met Asn Lys Glu Arg Lys Gly His His Ser Lys Leu Ile Tyr Ser Arg 
        755                 760                 765             


Leu Pro Ser Leu Arg Val Leu Ser Val Asp Leu Gly His Arg Phe Ala 
    770                 775                 780                 


Ala Ala Cys Ala Val Trp Glu Ser Met Ser Ala Ala Gln Met Arg Leu 
785                 790                 795                 800 


Ala Ala Ser Lys Gly Lys Val Val Arg Gly Gly Ile Ala Glu Gly Ala 
                805                 810                 815     


Leu Phe Ile His Ile Glu Ser Thr Val Ala Asp Gly Thr Val Arg Thr 
            820                 825                 830         


Thr Val Tyr Arg Arg Ile Gly Glu Asp Ala Leu Pro Asp Gly Ser Pro 
        835                 840                 845             


His Pro Ala Pro Trp Ala Lys Leu Glu Arg Gln Phe Leu Ile Lys Leu 
    850                 855                 860                 


Gln Gly Glu Glu Thr Pro Ser Arg Met Ala Ala Leu Asp Glu Leu Val 
865                 870                 875                 880 


Met Ile Ala Asp Trp Glu Arg Ala Leu Gly Tyr Gln Pro Val Thr Ala 
                885                 890                 895     


Ser Ser Thr Lys Gln Ser Asn Gly Val Ala Gly Leu Met Gly Arg Thr 
            900                 905                 910         


Val Arg Leu Phe Met His Ala Ser Arg Arg His Phe Asp Arg Ala Arg 
        915                 920                 925             


Ile Ala His Asn Leu Thr Ala Glu His Arg Thr Lys Pro Gly Gly Val 
    930                 935                 940                 


Pro Glu Ser Leu Thr Glu Glu Thr Arg Ile Glu Leu Leu Ile Asp Thr 
945                 950                 955                 960 


Leu Ala Leu Trp His Gly Leu Phe Ala Gly Asp Arg Trp Arg Asp Pro 
                965                 970                 975     


Arg Ala Gln Lys Glu Trp Glu Thr Ser Gly Leu Pro Ser Leu Lys Leu 
            980                 985                 990         


Pro Gly Arg Gly Asp Asp Asp Glu  Thr Ala Phe Gly Gly  Pro Gly Arg 
        995                 1000                 1005             


Lys Ala  Ala Met Val Val Tyr  Arg Asn Glu Leu Lys  Pro His Ala 
    1010                 1015                 1020             


Glu Arg  Met Ala His Ser Asp  Leu Ser Asn Leu Ser  Lys Cys Trp 
    1025                 1030                 1035             


Thr Asp  Arg Trp Ala Gln Asp  Asp Arg Glu Trp Thr  Ala Lys Ser 
    1040                 1045                 1050             


Gly Arg  Leu Arg Ser Leu Arg  Arg Trp Ile Thr Pro  Arg Gly Leu 
    1055                 1060                 1065             


Arg Pro  Val Ser Gly Asp Ser  Ala Gln Leu Ile Glu  Arg Lys Ala 
    1070                 1075                 1080             


Ala Ala  Ala Leu Arg Ala Arg  His Val Gly Gly Leu  Ser Met Gln 
    1085                 1090                 1095             


Arg Ile  Asn Thr Leu Thr Asp  Leu Tyr Arg Leu Leu  Lys Ser Phe 
    1100                 1105                 1110             


Lys Asn  Arg Pro Glu Pro Ser  Asn Leu Arg Lys Asn  Ile Pro Glu 
    1115                 1120                 1125             


Lys Gly  Asp Ala Arg Leu Ile  Gly Phe Asn Gln Arg  Leu Leu Asp 
    1130                 1135                 1140             


Val Arg  Asp Arg Leu Arg Glu  Gln Arg Val Lys Gln  Leu Ala Ser 
    1145                 1150                 1155             


Arg Ile  Val Glu Ala Ala Leu  Gly Ile Gly Arg Ile  Lys Ile Arg 
    1160                 1165                 1170             


Arg Val  Ala Ala Gly Ser Pro  Arg Pro Thr Leu Arg  Val Asp Ala 
    1175                 1180                 1185             


Ala Cys  His Ala Val Val Thr  Glu Asn Leu Ser Asn  Tyr Gln Pro 
    1190                 1195                 1200             


Ala Glu  Leu Gln Thr Arg Arg  Glu Asn Arg Gln Leu  Met Ala Trp 
    1205                 1210                 1215             


Ala Ser  Ser Lys Val His Lys  Tyr Leu Ala Glu Ser  Cys Gln Leu 
    1220                 1225                 1230             


His Gly  Leu His Leu Arg Glu  Val Gln Pro Asn Tyr  Thr Ser Arg 
    1235                 1240                 1245             


Gln Cys  Ser Arg Thr Gly Ala  Ala Gly Leu Arg Gly  Val Ala Val 
    1250                 1255                 1260             


Ser Ala  Thr Asp Leu Leu Thr  Asn Pro Trp Trp Met  Arg Asp Val 
    1265                 1270                 1275             


Ala Gln  Ala Lys Ala Arg Ile  Glu Lys Ala Leu Lys  Asn Gly Arg 
    1280                 1285                 1290             


Asn Gly  Ala Val Ala Asp Gln  Leu Leu Val Ser Ala  Glu Ala Trp 
    1295                 1300                 1305             


Ala Leu  Arg Ile Pro Glu Arg  Asp Arg His Asp Arg  Lys Ala Asp 
    1310                 1315                 1320             


Glu Ser  Val Lys Ala Phe His  Ala Glu Arg Val Ile  Leu Pro Arg 
    1325                 1330                 1335             


Lys Gly  Gly Asp Leu Phe Val  Ala Glu Ser Ala Arg  Cys Asn Gly 
    1340                 1345                 1350             


Lys Gly  His Val Pro Ala Leu  Gln Ala Asp Leu Asn  Ala Ala Ala 
    1355                 1360                 1365             


Asn Val  Gly Ile Arg Ala Leu  Leu Asp Pro Asp Trp  Pro Gly Lys 
    1370                 1375                 1380             


Trp Trp  Trp Val Pro Cys Val  Gly Gly Thr Tyr Ser  Pro Ser Pro 
    1385                 1390                 1395             


Glu Lys  Thr Ser Gly Ala Lys  Val Leu Glu His Ile  Asp Gln Leu 
    1400                 1405                 1410             


Pro His  Glu Met Val Asp Pro  Pro Gln Val Ala Pro  Lys Ser Ser 
    1415                 1420                 1425             


Ala Pro  Gln Pro Lys Ser Ser  Arg Ala Ala Lys Val  Lys Ala Lys 
    1430                 1435                 1440             


Glu Phe  Arg Ala Ile Glu Asn  Arg Trp Arg Thr Cys  Ser Ser Glu 
    1445                 1450                 1455             


Leu Leu  Ser Gln Gly Lys Trp  Ile Pro Ser Gly Glu  Tyr Trp Ser 
    1460                 1465                 1470             


Lys Val  Glu Ala Ala Val Cys  Leu Val Leu Asn Asp  Gln Ile Thr 
    1475                 1480                 1485             


<210> 612
<211> 1400
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 612
Met Ala Ala Phe Gln Arg Ser Tyr Thr Met Asn Leu Lys Pro Ala Thr 
1               5                   10                  15      


Ser Glu Gln Asp Lys Phe Ile Leu Trp Asn Arg Leu Phe Leu Thr His 
            20                  25                  30          


Trp Ser Val Asn Glu Gly Ala Lys Ile Phe Gly Glu Leu Phe Leu Asn 
        35                  40                  45              


Leu Arg Gly Gly Leu Ser Pro Glu Leu Asp Ile Phe Asp Leu Asp Lys 
    50                  55                  60                  


Val Lys Asp Asp Lys Lys Lys Lys Ala Phe Val Met Gly Arg Arg Arg 
65                  70                  75                  80  


Leu Leu Ala Leu Gly Trp Leu Ser Val Glu Asp Asn Leu Ser Ala Gly 
                85                  90                  95      


Glu His Pro Phe Arg Ile Arg Glu Ile Pro Val Gly Arg Asn Met Gly 
            100                 105                 110         


Lys Ser Gln Ala Ser Thr Leu Leu Thr Glu Ile Leu Lys Asn Lys Gly 
        115                 120                 125             


Ile Lys Asp Glu Ala Val Ile Lys Glu Trp Ile Asp Asp Cys Thr Pro 
    130                 135                 140                 


Ser Leu Ile Ala Asn Ile Arg Glu Asp Ala Val Trp Ile Asn Arg Ala 
145                 150                 155                 160 


Ser Ser Phe Asn Ser Ile Thr Pro Cys Pro Thr Lys Asp Glu Val Trp 
                165                 170                 175     


Ile Val Leu Ser Gly Leu Leu Gly Leu Arg Phe Leu Asp Leu Ser Leu 
            180                 185                 190         


Glu Glu Val Lys Gly Lys Glu Thr Glu Tyr Leu Tyr Asp Leu Gly Glu 
        195                 200                 205             


Lys Glu Thr Gln Ser Lys Ser Asp Pro Ser Lys Lys Ala Arg Glu Leu 
    210                 215                 220                 


Phe Gly Asn Leu Phe Thr Gln Asn Pro Val Leu Met Lys Asn Ser Arg 
225                 230                 235                 240 


Asp Lys Lys Asp Thr Phe Ala Lys Glu Phe Tyr Leu Ala Phe Lys Glu 
                245                 250                 255     


Phe Lys Asp Tyr Glu Lys Leu Lys Glu Lys Ile Glu Ser Trp Arg Lys 
            260                 265                 270         


Glu Lys Glu Phe Pro Leu Ile Glu Asn Pro Val Ala Glu Lys Tyr Pro 
        275                 280                 285             


Pro Glu Val Thr Phe Thr Gly Ser Pro Cys Thr Val Ser Lys Arg Tyr 
    290                 295                 300                 


Arg Lys Leu Leu Val Ser Leu Glu Leu Trp Pro Ser Ser Gln Asp Glu 
305                 310                 315                 320 


Asn Gly Asn Ile Pro Lys Thr Glu Lys Thr Glu Asp Lys Thr His Asn 
                325                 330                 335     


Gln Val Leu Leu Asp Tyr Leu Leu Lys Ala Cys Asn Glu Gly Asn Lys 
            340                 345                 350         


Gly Thr Gln Lys Ile Ile Thr Pro Val Trp Ala Asn Asn Leu Lys Ala 
        355                 360                 365             


Glu Leu Glu Leu Lys Met Asn Glu Ile Ile Arg Ile Gly Glu Ser Ser 
    370                 375                 380                 


Ser Thr Glu Leu Gln Arg Leu Met Ile Lys Met Ala Ala Arg Arg Ile 
385                 390                 395                 400 


Ser Gln Thr Leu Ser Trp Ile Lys Ile Asn Glu Gln Thr Lys His Asp 
                405                 410                 415     


Ala Tyr Gln Lys Lys Asn Lys Ala Phe Lys Leu Leu Ser Glu Ile Asp 
            420                 425                 430         


Lys Asn Gly Glu Ala Cys Lys Trp Leu Glu Asn Tyr Glu Leu Phe Arg 
        435                 440                 445             


Thr Asp Asp Ser Gly Gly Glu Glu Tyr His Ile Ser Leu Arg Ala Ile 
    450                 455                 460                 


Ser Cys Trp Lys Gln Ile Leu Glu Glu Trp Gln Lys Asn Asp Ser Pro 
465                 470                 475                 480 


Lys Ala Leu Arg Glu Lys Val Lys Glu Val Gln Ala Glu Glu Glu Lys 
                485                 490                 495     


Phe Gly Asp Ala Arg Leu Phe Glu Asp Leu Ala Asp Asp Asn Ala Arg 
            500                 505                 510         


Ser Val Trp Leu Leu Pro Asp Gly Asn Lys Thr Pro Asp Ile Leu Asn 
        515                 520                 525             


Trp Trp Cys Glu Tyr Arg Thr Ala Glu Ile Asp Glu Ser Arg Phe Lys 
    530                 535                 540                 


Ile Pro Cys Tyr Cys His Pro His Pro Phe Lys His Pro Val Tyr Val 
545                 550                 555                 560 


Glu Tyr Gly Lys Ser Asn Pro Lys Val Ile Phe Ala Met Lys Asn Asn 
                565                 570                 575     


Lys Val Lys Lys Gly His Ile Glu His Gly Trp Asn Pro Gln Asn Pro 
            580                 585                 590         


Arg Ser Ile Ala Leu Ser Leu Phe Asn Asn Gly Asn Arg Glu Ser Ser 
        595                 600                 605             


Leu Val Pro Phe Ile Trp Glu Ser Lys Arg Leu Trp Lys Asp Leu Gly 
    610                 615                 620                 


Gly Glu Ala Thr Gln Ile Gly Asp Ile Pro Arg Ser Asp Arg Met Gly 
625                 630                 635                 640 


Leu Ser Gly Lys Arg Glu Ser Val Lys Pro Lys Ala Pro Phe Gln Lys 
                645                 650                 655     


Glu Val Trp Asn Ala Arg Leu Gln Ser Asp Arg Arg Thr Leu Glu Lys 
            660                 665                 670         


Leu Glu Lys Tyr Trp Asn Pro Glu Ser Met Lys Trp Ile Asp Asp Gly 
        675                 680                 685             


Lys Phe Leu Ile Gln Ser Lys Trp Phe Ile Thr Phe Gly Pro Asp Met 
    690                 695                 700                 


Glu Thr Ala Glu Gly Pro Trp Lys Leu Tyr Leu Lys Glu Lys Tyr Val 
705                 710                 715                 720 


Asp Asn Lys Ile Leu Gly Asn Arg Ser Lys Glu Asn Gln Lys Arg Gly 
                725                 730                 735     


Tyr Arg Ala Lys Lys Leu Leu Ser Gly Tyr Pro Ala Gly Met Arg Ile 
            740                 745                 750         


Leu Ser Val Asp Leu Gly His Arg Tyr Ala Ala Ser Cys Ala Val Trp 
        755                 760                 765             


Glu Thr Ile Thr Lys Lys Gln Ile Thr Glu Glu Leu Ala Tyr Gln Pro 
    770                 775                 780                 


Asp Asn Asn Ser Leu Phe Glu His Ser Cys Lys Thr Ile Asp Lys Lys 
785                 790                 795                 800 


Ile Lys Asn Thr Val Tyr Arg Arg Ile Gly Glu Asp Ser Ile Asp Ala 
                805                 810                 815     


Pro Trp Ala Lys Leu Glu Lys Gln Phe Thr Ile Lys Leu Gln Gly Glu 
            820                 825                 830         


Asp Lys Ser Cys Tyr Leu Leu Arg Ser Asp Glu Lys Glu Leu Phe Arg 
        835                 840                 845             


Ser Ile Leu Ser Lys Leu Ser Cys Leu Asn Asn Asp Thr Gly His Asn 
    850                 855                 860                 


Ile Leu Glu Met Ile Glu Asn Leu Leu Arg Ile Val Lys Ala Lys Ile 
865                 870                 875                 880 


Tyr Arg Gln Gly Ile Leu Ala Arg Ile Ser Tyr Ser Met Thr Ala Gln 
                885                 890                 895     


Tyr Lys Pro Gly Lys Gly Gly Gln Lys Ser Pro Leu Ser Asp Glu Asp 
            900                 905                 910         


Lys Ile His Tyr Leu Ser Glu Asn Leu Ala Ala Trp Ser Ala Ile Met 
        915                 920                 925             


Gly Asn Gln Glu Trp Asn Glu Asp Val Ile Ser Asp Trp Tyr Lys Thr 
    930                 935                 940                 


Tyr Ile Ser His Leu Val Ser Gly Pro Lys Pro Lys Glu Gly Asn Arg 
945                 950                 955                 960 


Lys Ser Asp Arg Asp Lys Ile Ile Glu Tyr Phe Leu Pro Ala Ala Arg 
                965                 970                 975     


Lys Leu Tyr Asp Asp Asn Glu Thr Arg Ile Lys Ile His Asp Leu Phe 
            980                 985                 990         


Lys Glu Leu Trp Asp Glu Asn Asn  Lys Gln Leu Ser Ala  Val Leu Lys 
        995                 1000                 1005             


Glu Ile  Lys Lys Ile Ile Leu  Pro Lys Gly Ile Arg  Tyr Phe Asp 
    1010                 1015                 1020             


Lys Asn  Thr Asp Asn Pro Ser  Lys Trp Lys Asn Asn  Gln Ser Lys 
    1025                 1030                 1035             


Leu Lys  Gln Ile Thr His Arg  Gly Gly Leu Ser Met  Gln Arg Ile 
    1040                 1045                 1050             


Val Ala  Ile Glu Glu Tyr Tyr  Lys Leu Ala Lys Ala  Tyr Lys Asn 
    1055                 1060                 1065             


His Pro  Glu Pro Asp Asp Leu  Thr Lys Asn Ile Pro  Leu Pro Gly 
    1070                 1075                 1080             


Asp Asn  Ser Ser Ala Gly Phe  Asn Gln Arg Ile Arg  Asp Thr Leu 
    1085                 1090                 1095             


Glu Arg  Met Lys Glu Gln Arg  Val Lys Gln Ile Ala  Ser Arg Ile 
    1100                 1105                 1110             


Val Glu  Ser Ala Leu Gly Leu  Gly Ile Glu Gly Tyr  Lys Lys Arg 
    1115                 1120                 1125             


Pro Leu  Thr Pro Glu Asn Lys  Pro Cys Gln Ala Ile  Val Ile Glu 
    1130                 1135                 1140             


Asp Leu  Ser His Tyr Arg Pro  Asp Glu Leu Gln Thr  Arg Arg Glu 
    1145                 1150                 1155             


Asn Arg  Arg Leu Met Gln Trp  Ser Ser Ser Lys Val  Lys Lys Tyr 
    1160                 1165                 1170             


Leu Lys  Glu Ala Cys Glu Met  His Asp Val Arg Leu  Val Glu Ile 
    1175                 1180                 1185             


Ser Pro  Glu Tyr Thr Ser Arg  Gln Asp Ser Arg Thr  Gly Ala Ala 
    1190                 1195                 1200             


Gly Leu  Arg Cys Ile Asp Ile  Asn Ile Arg Glu Phe  Leu Lys Asp 
    1205                 1210                 1215             


Ser Ser  Arg Trp Gln Asn Lys  Ile Asn Thr Ile Gln  Lys Lys Pro 
    1220                 1225                 1230             


Ala Asn  Lys Lys Ser Asn Leu  Asp Gln Tyr Leu Ile  Glu Leu Asn 
    1235                 1240                 1245             


Glu Ser  Leu Gly Asn Lys Tyr  Lys Asp Lys Val Ile  Pro Ser Asp 
    1250                 1255                 1260             


Asn Phe  Val Arg Ile Pro Arg  Lys Gly Gly Asp Val  Phe Val Ser 
    1265                 1270                 1275             


Ser Ser  Lys Glu Ser Pro Val  Ser Lys Gly Ile Gln  Ala Asp Leu 
    1280                 1285                 1290             


Asn Ala  Ala Ala Asn Ile Gly  Leu Lys Ala Leu Leu  Asp Pro Asp 
    1295                 1300                 1305             


Trp Ala  Gly Ala Trp Trp Tyr  Ile Leu Ile Glu Val  Lys Ser Asn 
    1310                 1315                 1320             


His Val  Ile Pro Tyr Gly Glu  Lys Tyr Lys Gly Ser  Glu Cys Leu 
    1325                 1330                 1335             


Arg Ala  Trp Lys Phe Ser Gly  Leu Glu Asn Gln Val  Met Lys Asn 
    1340                 1345                 1350             


Asn Met  Asn Leu Trp Arg Asp  Leu Gln Ser Gln Phe  Ser Gly Glu 
    1355                 1360                 1365             


Asp Lys  Trp Met Ser Tyr Lys  Glu Tyr Asn Glu Leu  Thr Glu Lys 
    1370                 1375                 1380             


Arg Val  Ile Asn Ile Leu Arg  Glu Arg Ala Gly Leu  Glu Leu Ile 
    1385                 1390                 1395             


Lys Glu  
    1400 


<210> 613
<211> 1263
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 613
Met Glu Asp Tyr Ser Gly Phe Val Asn Ile Tyr Ser Ile Gln Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Glu His Ile Glu 
            20                  25                  30          


Lys Lys Gly Phe Leu Lys Lys Asp Lys Ile Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Ala Val Lys Lys Ile Ile Asp Lys Tyr His Arg Ala Tyr Ile Glu Glu 
    50                  55                  60                  


Val Phe Asp Ser Val Leu His Gln Lys Lys Lys Lys Asp Lys Thr Arg 
65                  70                  75                  80  


Phe Ser Thr Gln Phe Ile Lys Glu Ile Lys Glu Phe Ser Glu Leu Tyr 
                85                  90                  95      


Tyr Lys Thr Glu Lys Asn Ile Pro Asp Lys Glu Arg Leu Glu Ala Leu 
            100                 105                 110         


Ser Glu Lys Leu Arg Lys Met Leu Val Gly Ala Phe Lys Gly Glu Phe 
        115                 120                 125             


Ser Glu Glu Val Ala Glu Lys Tyr Lys Asn Leu Phe Ser Lys Glu Leu 
    130                 135                 140                 


Ile Arg Asn Glu Ile Glu Lys Phe Cys Glu Thr Asp Glu Glu Arg Lys 
145                 150                 155                 160 


Gln Val Ser Asn Phe Lys Ser Phe Thr Thr Tyr Phe Thr Gly Phe His 
                165                 170                 175     


Ser Asn Arg Gln Asn Ile Tyr Ser Asp Glu Lys Lys Ser Thr Ala Ile 
            180                 185                 190         


Gly Tyr Arg Ile Ile His Gln Asn Leu Pro Lys Phe Leu Asp Asn Leu 
        195                 200                 205             


Lys Ile Ile Glu Ser Ile Gln Arg Arg Phe Lys Asp Phe Pro Trp Ser 
    210                 215                 220                 


Asp Leu Lys Lys Asn Leu Lys Lys Ile Asp Lys Asn Ile Lys Leu Thr 
225                 230                 235                 240 


Glu Tyr Phe Ser Ile Asp Gly Phe Val Asn Val Leu Asn Gln Lys Gly 
                245                 250                 255     


Ile Asp Ala Tyr Asn Thr Ile Leu Gly Gly Lys Ser Glu Glu Ser Gly 
            260                 265                 270         


Glu Lys Ile Gln Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Arg Gln Lys 
        275                 280                 285             


Asn Asn Ile Asp Arg Lys Asn Leu Pro Asn Val Lys Ile Leu Phe Lys 
    290                 295                 300                 


Gln Ile Leu Gly Asp Arg Glu Thr Lys Ser Phe Ile Pro Glu Ala Phe 
305                 310                 315                 320 


Pro Asp Asp Gln Ser Val Leu Asn Ser Ile Thr Glu Phe Ala Lys Tyr 
                325                 330                 335     


Leu Lys Leu Asp Lys Lys Lys Lys Ser Ile Ile Ala Glu Leu Lys Lys 
            340                 345                 350         


Phe Leu Ser Ser Phe Asn Arg Tyr Glu Leu Asp Gly Ile Tyr Leu Ala 
        355                 360                 365             


Asn Asp Asn Ser Leu Ala Ser Ile Ser Thr Phe Leu Phe Asp Asp Trp 
    370                 375                 380                 


Ser Phe Ile Lys Lys Ser Val Ser Phe Lys Tyr Asp Glu Ser Val Gly 
385                 390                 395                 400 


Asp Pro Lys Lys Lys Ile Lys Ser Pro Leu Lys Tyr Glu Lys Glu Lys 
                405                 410                 415     


Glu Lys Trp Leu Lys Gln Lys Tyr Tyr Thr Ile Ser Phe Leu Asn Asp 
            420                 425                 430         


Ala Ile Glu Ser Tyr Ser Lys Ser Gln Asp Glu Lys Arg Val Lys Ile 
        435                 440                 445             


Arg Leu Glu Ala Tyr Phe Ala Glu Phe Lys Ser Lys Asp Asp Ala Lys 
    450                 455                 460                 


Lys Gln Phe Asp Leu Leu Glu Arg Ile Glu Glu Ala Tyr Ala Ile Val 
465                 470                 475                 480 


Glu Pro Leu Leu Gly Ala Glu Tyr Pro Arg Asp Arg Asn Leu Lys Ala 
                485                 490                 495     


Asp Lys Lys Glu Val Gly Lys Ile Lys Asp Phe Leu Asp Ser Ile Lys 
            500                 505                 510         


Ser Leu Gln Phe Phe Leu Lys Pro Leu Leu Ser Ala Glu Ile Phe Asp 
        515                 520                 525             


Glu Lys Asp Leu Gly Phe Tyr Asn Gln Leu Glu Gly Tyr Tyr Glu Glu 
    530                 535                 540                 


Ile Asp Ser Ile Gly His Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr 
545                 550                 555                 560 


Gly Lys Ile Tyr Ser Lys Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser 
                565                 570                 575     


Thr Leu Leu Lys Gly Trp Asp Glu Asn Arg Glu Val Ala Asn Leu Cys 
            580                 585                 590         


Val Ile Phe Arg Glu Asp Gln Lys Tyr Tyr Leu Gly Val Met Asp Lys 
        595                 600                 605             


Glu Asn Asn Thr Ile Leu Ser Asp Ile Pro Lys Val Lys Pro Asn Glu 
    610                 615                 620                 


Leu Phe Tyr Glu Lys Met Val Tyr Lys Leu Ile Pro Thr Pro His Met 
625                 630                 635                 640 


Gln Leu Pro Arg Ile Ile Phe Ser Ser Asp Asn Leu Ser Ile Tyr Asn 
                645                 650                 655     


Pro Ser Lys Ser Ile Leu Lys Ile Arg Glu Ala Lys Ser Phe Lys Glu 
            660                 665                 670         


Gly Lys Asn Phe Lys Leu Lys Asp Cys His Lys Phe Ile Asp Phe Tyr 
        675                 680                 685             


Lys Glu Ser Ile Ser Lys Asn Glu Asp Trp Ser Arg Phe Asp Phe Lys 
    690                 695                 700                 


Phe Ser Lys Thr Ser Ser Tyr Glu Asn Ile Ser Glu Phe Tyr Arg Glu 
705                 710                 715                 720 


Val Glu Arg Gln Gly Tyr Asn Leu Asp Phe Lys Lys Val Ser Lys Phe 
                725                 730                 735     


Tyr Ile Asp Ser Leu Val Glu Asp Gly Lys Leu Tyr Leu Phe Gln Ile 
            740                 745                 750         


Tyr Asn Lys Asp Phe Ser Ile Phe Ser Lys Gly Lys Pro Asn Leu His 
        755                 760                 765             


Thr Ile Tyr Phe Arg Ser Leu Phe Ser Lys Glu Asn Leu Lys Asp Val 
    770                 775                 780                 


Cys Leu Lys Leu Asn Gly Glu Ala Glu Met Phe Phe Arg Lys Lys Ser 
785                 790                 795                 800 


Ile Asn Tyr Asp Glu Lys Lys Lys Arg Glu Gly His His Pro Glu Leu 
                805                 810                 815     


Phe Glu Lys Leu Lys Tyr Pro Ile Leu Lys Asp Lys Arg Tyr Ser Glu 
            820                 825                 830         


Asp Lys Phe Gln Phe His Leu Pro Ile Ser Leu Asn Phe Lys Ser Lys 
        835                 840                 845             


Glu Arg Leu Asn Phe Asn Leu Lys Val Asn Glu Phe Leu Lys Arg Asn 
    850                 855                 860                 


Lys Asp Ile Asn Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu Leu 
865                 870                 875                 880 


Tyr Leu Val Met Ile Asn Gln Lys Gly Glu Ile Leu Lys Gln Thr Leu 
                885                 890                 895     


Leu Asp Ser Met Gln Ser Gly Lys Gly Arg Pro Glu Ile Asn Tyr Lys 
            900                 905                 910         


Glu Lys Leu Gln Glu Lys Glu Ile Glu Arg Asp Lys Ala Arg Lys Ser 
        915                 920                 925             


Trp Gly Thr Val Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Leu Ser 
    930                 935                 940                 


Ile Val Ile His Gln Ile Ser Lys Leu Met Val Glu Asn Asn Ala Ile 
945                 950                 955                 960 


Val Val Leu Glu Asp Leu Asn Ile Gly Phe Lys Arg Gly Arg Gln Lys 
                965                 970                 975     


Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys 
            980                 985                 990         


Leu Asn Phe Leu Val Phe Lys Glu  Asn Lys Pro Thr Glu  Pro Gly Gly 
        995                 1000                 1005             


Val Leu  Lys Ala Tyr Gln Leu  Thr Asp Glu Phe Gln  Ser Phe Glu 
    1010                 1015                 1020             


Lys Leu  Ser Lys Gln Thr Gly  Phe Leu Phe Tyr Val  Pro Ser Trp 
    1025                 1030                 1035             


Asn Thr  Ser Lys Ile Asp Pro  Arg Thr Gly Phe Ile  Asp Phe Leu 
    1040                 1045                 1050             


His Pro  Ala Tyr Glu Asn Ile  Glu Lys Ala Lys Gln  Trp Ile Asn 
    1055                 1060                 1065             


Lys Phe  Asp Ser Ile Arg Phe  Asn Ser Lys Met Asp  Trp Phe Glu 
    1070                 1075                 1080             


Phe Thr  Ala Asp Thr Arg Lys  Phe Ser Glu Asn Leu  Met Leu Gly 
    1085                 1090                 1095             


Lys Asn  Arg Val Trp Val Ile  Cys Thr Thr Asn Val  Glu Arg Tyr 
    1100                 1105                 1110             


Phe Thr  Ser Lys Thr Ala Asn  Ser Ser Ile Gln Tyr  Asn Ser Ile 
    1115                 1120                 1125             


Gln Ile  Thr Glu Lys Leu Lys  Glu Leu Phe Val Asp  Ile Pro Phe 
    1130                 1135                 1140             


Ser Asn  Gly Gln Asp Leu Lys  Pro Glu Ile Leu Arg  Lys Asn Asp 
    1145                 1150                 1155             


Ala Val  Phe Phe Lys Ser Leu  Leu Phe Tyr Ile Lys  Thr Thr Leu 
    1160                 1165                 1170             


Ser Leu  Arg Gln Asn Asn Gly  Lys Lys Gly Glu Glu  Glu Lys Asp 
    1175                 1180                 1185             


Phe Ile  Leu Ser Pro Val Val  Asp Ser Lys Gly Arg  Phe Phe Asn 
    1190                 1195                 1200             


Ser Leu  Glu Ala Ser Asp Asp  Glu Pro Lys Asp Ala  Asp Ala Asn 
    1205                 1210                 1215             


Gly Ala  Tyr His Ile Ala Leu  Lys Gly Leu Met Asn  Leu Leu Val 
    1220                 1225                 1230             


Leu Asn  Glu Thr Lys Glu Glu  Asn Leu Ser Arg Pro  Lys Trp Lys 
    1235                 1240                 1245             


Ile Lys  Asn Lys Asp Trp Leu  Glu Phe Val Trp Glu  Arg Asn Arg 
    1250                 1255                 1260             


<210> 614
<211> 1193
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 614
Met Lys Arg Ile Ala Lys Phe Arg His Asp Lys Pro Val Lys Arg Glu 
1               5                   10                  15      


Ala Trp Ser Lys Gly Tyr Arg Val His Lys Asn Arg Ile Ile Asn Lys 
            20                  25                  30          


Val Thr Arg Ser Ile Lys Tyr Pro Leu Val Val Lys Asp Glu Trp Lys 
        35                  40                  45              


Lys Arg Leu Ile Asp Asp Ala Ala His Asp Tyr Arg Trp Leu Val Gly 
    50                  55                  60                  


Pro Ile Asn Tyr Ser Asp Trp Cys Arg Asp Pro Asn Gln Tyr Ser Ile 
65                  70                  75                  80  


Leu Glu Phe Trp Ile Asp Phe Leu Cys Val Gly Gly Val Phe Gln Ser 
                85                  90                  95      


Ser His Ser Asn Ile Cys Arg Leu Ala Ile Gln Leu Ser Gly Gly Ser 
            100                 105                 110         


Val Phe Glu Gln Glu Trp Lys Asp Leu Ser Pro Phe Val Arg Ala Asn 
        115                 120                 125             


Leu Ile Gln Gly Ile Lys Pro Ala Glu Phe Ile Gly Phe Leu Thr Ala 
    130                 135                 140                 


Glu Phe Arg Ser Ser Ser Asn Pro Lys Asn Phe Ile Ser Lys Phe Phe 
145                 150                 155                 160 


Glu Gly Ser Asn Glu Asp Leu Glu Ser Leu Thr Asn Glu Phe Ala Ser 
                165                 170                 175     


Ile Val Asp Phe Ile Lys Ala Lys Asp Ile Ser Leu Leu Arg Lys Ser 
            180                 185                 190         


Leu Pro Ser Cys Lys Lys Ile Ala Pro Asn Leu Trp Glu Lys Ala Val 
        195                 200                 205             


Gly Ser His Ser Thr Asn Glu Leu Leu Lys Leu Leu Thr Lys Tyr Thr 
    210                 215                 220                 


Arg Val Met Leu Val Ala Glu Pro Ser His Ser Asp Arg Val Phe Ser 
225                 230                 235                 240 


Gln Thr Val Leu Gln Ser Asn Asp Gln Asp Asp Pro Glu Leu Thr Gly 
                245                 250                 255     


Pro Leu Pro Ser His Lys Val Gly Lys Ala Ser Tyr Leu Phe Ile Pro 
            260                 265                 270         


Glu Phe Ile Arg Glu Val Asn Leu Asp Lys Ile Ser Lys Leu Asp Leu 
        275                 280                 285             


Ser Ala Lys Ser Lys Leu Ala Val Glu Gln Val Lys Lys Leu Ser Glu 
    290                 295                 300                 


Leu Thr Ser Asp Phe Lys Gln Ile Glu Asn Gln Ser Glu Ala Tyr Phe 
305                 310                 315                 320 


Gly Leu Ser Thr Ser Phe Asn Glu Leu Ser Asn Phe Leu Gly Ile Leu 
                325                 330                 335     


Ile Arg Thr Leu Arg Asn Ala Pro Glu Ala Ile Leu Lys Asp Gln Ile 
            340                 345                 350         


Ala Leu Cys Ala Pro Leu Asp Lys Asp Ile Leu Lys Ile Thr Leu Asp 
        355                 360                 365             


Trp Leu Cys Asp Arg Ala Gln Ala Leu Pro Glu Asn Pro Arg Phe Glu 
    370                 375                 380                 


Thr Asn Trp Ala Glu Tyr Arg Ser Tyr Leu Gly Gly Lys Ile Lys Ser 
385                 390                 395                 400 


Trp Phe Ser Asn Tyr Glu Asn Phe Phe Glu Ile Pro Gln Ala Ala Ser 
                405                 410                 415     


Ser Gln Gln Asn Asn Asn Arg Glu Lys Lys Leu Gly Asn Arg Ser Ala 
            420                 425                 430         


Ile Arg Ala Leu Asn Leu Lys Lys Glu Ala Phe Glu Lys Ala Arg Glu 
        435                 440                 445             


Thr Phe Lys Gly Asp Lys Gly Thr Leu Glu Lys Ile Asp Leu Ala Tyr 
    450                 455                 460                 


Arg Leu Leu Gly Ser Ile Ser Pro Glu Val Leu Gln Cys Asp Glu Gly 
465                 470                 475                 480 


Leu Lys Leu Tyr Gln Gln Phe Asn Asp Glu Leu Leu Val Leu Asn Glu 
                485                 490                 495     


Thr Ile Asn Gln Lys Phe Gln Asp Ala Lys Arg Asp Ile Lys Ala Lys 
            500                 505                 510         


Lys Glu Lys Glu Ser Phe Glu Lys Leu Gln Arg Asn Leu Ser Ser Pro 
        515                 520                 525             


Leu Pro Arg Ile Pro Glu Phe Phe Gly Glu Arg Ala Lys Lys Gly Tyr 
    530                 535                 540                 


Gln Lys Ala Arg Val Ser Pro Lys Leu Ala Arg His Leu Leu Glu Cys 
545                 550                 555                 560 


Leu Asn Asp Trp Leu Ala Arg Phe Ala Lys Val Glu Glu Ser Ala Phe 
                565                 570                 575     


Ser Glu Lys Glu Phe Gln Arg Ile Leu Asp Trp Leu Arg Thr Ser Asp 
            580                 585                 590         


Phe Leu Pro Val Phe Ile Arg Lys Ser Lys Asp Pro Pro Ser Trp Leu 
        595                 600                 605             


Arg Tyr Ile Ala Arg Val Ala Thr Gly Lys Tyr Tyr Phe Trp Val Ser 
    610                 615                 620                 


Glu Tyr Ser Arg Lys Arg Val Gln Ile Ile Asp Lys Pro Ile Ala Gln 
625                 630                 635                 640 


Asn Pro Leu Lys Glu Leu Ile Ser Trp Phe Leu Leu Asn Lys Asp Ala 
                645                 650                 655     


Phe Ser Arg Asp Asn Glu Leu Phe Lys Gly Leu Ser Ser Lys Met Val 
            660                 665                 670         


Thr Leu Ala Arg Ile Met Ala Gly Ile Leu Arg Asp Arg Gly Glu Gly 
        675                 680                 685             


Leu Lys Glu Leu Gln Ala Met Thr Ser Lys Leu Asp Asn Ile Gly Leu 
    690                 695                 700                 


Leu His Pro Ser Phe Ser Val Pro Val Thr Asp Ser Leu Lys Asp Ala 
705                 710                 715                 720 


Ala Phe Tyr Arg Ala Phe Phe Ser Glu Leu Glu Gly Leu Leu Asn Ile 
                725                 730                 735     


Gly Arg Ser Arg Leu Ile Ile Glu Arg Ile Thr Leu Gln Ser Gln Gln 
            740                 745                 750         


Ser Lys Asn Lys Lys Thr Arg Arg Pro Leu Met Pro Glu Pro Phe Ile 
        755                 760                 765             


Asn Glu Asp Lys Glu Val Phe Leu Ala Phe Pro Lys Phe Glu Thr Lys 
    770                 775                 780                 


Asn Lys Val Lys Gly Thr Arg Val Val Tyr Asn Ser Pro Asp Glu Val 
785                 790                 795                 800 


Asn Trp Leu Leu Ser Pro Ile Arg Ser Ser Lys Gly Gln Leu Ser Phe 
                805                 810                 815     


Met Phe Arg Cys Leu Ser Glu Asp Ala Lys Ile Met Thr Thr Ser Gly 
            820                 825                 830         


Gly Cys Ser Tyr Ile Val Glu Phe Lys Lys Leu Leu Glu Ala Gln Glu 
        835                 840                 845             


Glu Val Leu Ser Ile His Asp Cys Asp Ile Ile Pro Arg Ala Phe Val 
    850                 855                 860                 


Ser Ile Pro Phe Thr Leu Glu Arg Glu Ser Glu Glu Thr Lys Pro Asp 
865                 870                 875                 880 


Trp Lys Pro Asn Arg Phe Met Gly Val Asp Ile Gly Glu Tyr Ala Val 
                885                 890                 895     


Ala Tyr Cys Val Ile Glu Lys Gly Thr Asp Ser Ile Glu Ile Leu Asp 
            900                 905                 910         


Cys Gly Ile Val Arg Asn Gly Ala His Arg Val Leu Lys Glu Lys Val 
        915                 920                 925             


Asp Arg Leu Lys Arg Arg Gln Arg Ser Met Thr Phe Gly Ala Met Asp 
    930                 935                 940                 


Thr Ser Ile Ala Ala Ala Arg Glu Ser Leu Val Gly Asn Tyr Arg Asn 
945                 950                 955                 960 


Arg Leu His Ala Ile Ala Leu Lys His Gly Ala Lys Leu Val Tyr Glu 
                965                 970                 975     


Tyr Glu Val Ser Ala Phe Glu Ser Gly Gly Asn Arg Ile Lys Lys Val 
            980                 985                 990         


Tyr Glu Thr Leu Lys Lys Ser Asp  Cys Thr Gly Glu Thr  Glu Ala Asp 
        995                 1000                 1005             


Lys Asn  Ala Arg Lys His Ile  Trp Gly Glu Thr Asn  Ala Val Gly 
    1010                 1015                 1020             


Asp Gln  Ile Gly Ala Gly Trp  Thr Ser Gln Thr Cys  Ala Lys Cys 
    1025                 1030                 1035             


Gly Arg  Ser Phe Gly Ala Asp  Leu Lys Ala Gly Asn  Phe Gly Val 
    1040                 1045                 1050             


Ala Val  Pro Val Pro Glu Lys  Val Glu Asp Ser Lys  Gly His Tyr 
    1055                 1060                 1065             


Ala Tyr  His Glu Phe Pro Phe  Glu Asp Gly Leu Lys  Val Arg Gly 
    1070                 1075                 1080             


Phe Leu  Lys Pro Asn Lys Ile  Ile Ser Asp Gln Lys  Glu Leu Ala 
    1085                 1090                 1095             


Lys Ala  Val His Ala Tyr Met  Arg Pro Pro Leu Val  Ala Leu Gly 
    1100                 1105                 1110             


Lys Arg  Lys Leu Pro Lys Asn  Ala Arg Tyr Arg Arg  Gly Asn Ser 
    1115                 1120                 1125             


Ser Leu  Phe Arg Cys Pro Phe  Ser Asp Cys Gly Phe  Thr Ala Asp 
    1130                 1135                 1140             


Ala Asp  Ile Gln Ala Ala Tyr  Asn Ile Ala Val Lys  Gln Leu Tyr 
    1145                 1150                 1155             


Lys Pro  Lys Lys Gly Tyr Pro  Lys Glu Arg Lys Trp  Gln Asp Phe 
    1160                 1165                 1170             


Val Ile  Leu Lys Pro Lys Glu  Pro Ser Lys Leu Phe  Asp Lys Gln 
    1175                 1180                 1185             


Phe Tyr  Arg Pro Asn 
    1190             


<210> 615
<211> 1108
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 615
Met Ala Ile Arg Ser Ile Lys Leu Lys Leu Lys Thr His Thr Gly Pro 
1               5                   10                  15      


Glu Ala Gln Asn Leu Arg Lys Gly Ile Trp Arg Thr His Arg Leu Leu 
            20                  25                  30          


Asn Glu Gly Val Ala Tyr Tyr Met Lys Met Leu Leu Leu Phe Arg Gln 
        35                  40                  45              


Glu Ser Thr Gly Glu Arg Pro Lys Glu Glu Leu Gln Glu Glu Leu Ile 
    50                  55                  60                  


Cys His Ile Arg Glu Gln Gln Gln Arg Asn Gln Ala Asp Lys Asn Thr 
65                  70                  75                  80  


Gln Ala Leu Pro Leu Asp Lys Ala Leu Glu Ala Leu Arg Gln Leu Tyr 
                85                  90                  95      


Glu Leu Leu Val Pro Ser Ser Val Gly Gln Ser Gly Asp Ala Gln Ile 
            100                 105                 110         


Ile Ser Arg Lys Phe Leu Ser Pro Leu Val Asp Pro Asn Ser Glu Gly 
        115                 120                 125             


Gly Lys Gly Thr Ser Lys Ala Gly Ala Lys Pro Thr Trp Gln Lys Lys 
    130                 135                 140                 


Lys Glu Ala Asn Asp Pro Thr Trp Glu Gln Asp Tyr Glu Lys Trp Lys 
145                 150                 155                 160 


Lys Arg Arg Glu Glu Asp Pro Thr Ala Ser Val Ile Thr Thr Leu Glu 
                165                 170                 175     


Glu Tyr Gly Ile Arg Pro Ile Phe Pro Leu Tyr Thr Asn Thr Val Thr 
            180                 185                 190         


Asp Ile Ala Trp Leu Pro Leu Gln Ser Asn Gln Phe Val Arg Thr Trp 
        195                 200                 205             


Asp Arg Asp Met Leu Gln Gln Ala Ile Glu Arg Leu Leu Ser Trp Glu 
    210                 215                 220                 


Ser Trp Asn Lys Arg Val Gln Glu Glu Tyr Ala Lys Leu Lys Glu Lys 
225                 230                 235                 240 


Met Ala Gln Leu Asn Glu Gln Leu Glu Gly Gly Gln Glu Trp Ile Ser 
                245                 250                 255     


Leu Leu Glu Gln Tyr Glu Glu Asn Arg Glu Arg Glu Leu Arg Glu Asn 
            260                 265                 270         


Met Thr Ala Ala Asn Asp Lys Tyr Arg Ile Thr Lys Arg Gln Met Lys 
        275                 280                 285             


Gly Trp Asn Glu Leu Tyr Glu Leu Trp Ser Thr Phe Pro Ala Ser Ala 
    290                 295                 300                 


Ser His Glu Gln Tyr Lys Glu Ala Leu Lys Arg Val Gln Gln Arg Leu 
305                 310                 315                 320 


Arg Gly Arg Phe Gly Asp Ala His Phe Phe Gln Tyr Leu Met Glu Glu 
                325                 330                 335     


Lys Asn Arg Leu Ile Trp Lys Gly Asn Pro Gln Arg Ile His Tyr Phe 
            340                 345                 350         


Val Ala Arg Asn Glu Leu Thr Lys Arg Leu Glu Glu Ala Lys Gln Ser 
        355                 360                 365             


Ala Thr Met Thr Leu Pro Asn Ala Arg Lys His Pro Leu Trp Val Arg 
    370                 375                 380                 


Phe Asp Ala Arg Gly Gly Asn Leu Gln Asp Tyr Tyr Leu Thr Ala Glu 
385                 390                 395                 400 


Ala Asp Lys Pro Arg Ser Arg Arg Phe Val Thr Phe Ser Gln Leu Ile 
                405                 410                 415     


Trp Pro Ser Glu Ser Gly Trp Met Glu Lys Lys Asp Val Glu Val Glu 
            420                 425                 430         


Leu Ala Leu Ser Arg Gln Phe Tyr Gln Gln Val Lys Leu Leu Lys Asn 
        435                 440                 445             


Asp Lys Gly Lys Gln Lys Ile Glu Phe Lys Asp Lys Gly Ser Gly Ser 
    450                 455                 460                 


Thr Phe Asn Gly His Leu Gly Gly Ala Lys Leu Gln Leu Glu Arg Gly 
465                 470                 475                 480 


Asp Leu Glu Lys Glu Glu Lys Asn Phe Glu Asp Gly Glu Ile Gly Ser 
                485                 490                 495     


Val Tyr Leu Asn Val Val Ile Asp Phe Glu Pro Leu Gln Glu Val Lys 
            500                 505                 510         


Asn Gly Arg Val Gln Ala Pro Tyr Gly Gln Val Leu Gln Leu Ile Arg 
        515                 520                 525             


Arg Pro Asn Glu Phe Pro Lys Val Thr Thr Tyr Lys Ser Glu Gln Leu 
    530                 535                 540                 


Val Glu Trp Ile Lys Ala Ser Pro Gln His Ser Ala Gly Val Glu Ser 
545                 550                 555                 560 


Leu Ala Ser Gly Phe Arg Val Met Ser Ile Asp Leu Gly Leu Arg Ala 
                565                 570                 575     


Ala Ala Ala Thr Ser Ile Phe Ser Val Glu Glu Ser Ser Asp Lys Asn 
            580                 585                 590         


Ala Ala Asp Phe Ser Tyr Trp Ile Glu Gly Thr Pro Leu Val Ala Val 
        595                 600                 605             


His Gln Arg Ser Tyr Met Leu Arg Leu Pro Gly Glu Gln Val Glu Lys 
    610                 615                 620                 


Gln Val Met Glu Lys Arg Asp Glu Arg Phe Gln Leu His Gln Arg Val 
625                 630                 635                 640 


Lys Phe Gln Ile Arg Val Leu Ala Gln Ile Met Arg Met Ala Asn Lys 
                645                 650                 655     


Gln Tyr Gly Asp Arg Trp Asp Glu Leu Asp Ser Leu Lys Gln Ala Val 
            660                 665                 670         


Glu Gln Lys Lys Ser Pro Leu Asp Gln Thr Asp Arg Thr Phe Trp Glu 
        675                 680                 685             


Gly Ile Val Cys Asp Leu Thr Lys Val Leu Pro Arg Asn Glu Ala Asp 
    690                 695                 700                 


Trp Glu Gln Ala Val Val Gln Ile His Arg Lys Ala Glu Glu Tyr Val 
705                 710                 715                 720 


Gly Lys Ala Val Gln Ala Trp Arg Lys Arg Phe Ala Ala Asp Glu Arg 
                725                 730                 735     


Lys Gly Ile Ala Gly Leu Ser Met Trp Asn Ile Glu Glu Leu Glu Gly 
            740                 745                 750         


Leu Arg Lys Leu Leu Ile Ser Trp Ser Arg Arg Thr Arg Asn Pro Gln 
        755                 760                 765             


Glu Val Asn Arg Phe Glu Arg Gly His Thr Ser His Gln Arg Leu Leu 
    770                 775                 780                 


Thr His Ile Gln Asn Val Lys Glu Asp Arg Leu Lys Gln Leu Ser His 
785                 790                 795                 800 


Ala Ile Val Met Thr Ala Leu Gly Tyr Val Tyr Asp Glu Arg Lys Gln 
                805                 810                 815     


Glu Trp Cys Ala Glu Tyr Pro Ala Cys Gln Val Ile Leu Phe Glu Asn 
            820                 825                 830         


Leu Ser Gln Tyr Arg Ser Asn Leu Asp Arg Ser Thr Lys Glu Asn Ser 
        835                 840                 845             


Thr Leu Met Lys Trp Ala His Arg Ser Ile Pro Lys Tyr Val His Met 
    850                 855                 860                 


Gln Ala Glu Pro Tyr Gly Ile Gln Ile Gly Asp Val Arg Ala Glu Tyr 
865                 870                 875                 880 


Ser Ser Arg Phe Tyr Ala Lys Thr Gly Thr Pro Gly Ile Arg Cys Lys 
                885                 890                 895     


Lys Val Arg Gly Gln Asp Leu Gln Gly Arg Arg Phe Glu Asn Leu Gln 
            900                 905                 910         


Lys Arg Leu Val Asn Glu Gln Phe Leu Thr Glu Glu Gln Val Lys Gln 
        915                 920                 925             


Leu Arg Pro Gly Asp Ile Val Pro Asp Asp Ser Gly Glu Leu Phe Met 
    930                 935                 940                 


Thr Leu Thr Asp Gly Ser Gly Ser Lys Glu Val Val Phe Leu Gln Ala 
945                 950                 955                 960 


Asp Ile Asn Ala Ala His Asn Leu Gln Lys Arg Phe Trp Gln Arg Tyr 
                965                 970                 975     


Asn Glu Leu Phe Lys Val Ser Cys Arg Val Ile Val Arg Asp Glu Glu 
            980                 985                 990         


Glu Tyr Leu Val Pro Lys Thr Lys  Ser Val Gln Ala Lys  Leu Gly Lys 
        995                 1000                 1005             


Gly Leu  Phe Val Lys Lys Ser  Asp Thr Ala Trp Lys  Asp Val Tyr 
    1010                 1015                 1020             


Val Trp  Asp Ser Gln Ala Lys  Leu Lys Gly Lys Thr  Thr Phe Thr 
    1025                 1030                 1035             


Glu Glu  Ser Glu Ser Pro Glu  Gln Leu Glu Asp Phe  Gln Glu Ile 
    1040                 1045                 1050             


Ile Glu  Glu Ala Glu Glu Ala  Lys Gly Thr Tyr Arg  Thr Leu Phe 
    1055                 1060                 1065             


Arg Asp  Pro Ser Gly Val Phe  Phe Pro Glu Ser Val  Trp Tyr Pro 
    1070                 1075                 1080             


Gln Lys  Asp Phe Trp Gly Glu  Val Lys Arg Lys Leu  Tyr Gly Lys 
    1085                 1090                 1095             


Leu Arg  Glu Arg Phe Leu Thr  Lys Ala Arg 
    1100                 1105             


<210> 616
<211> 1283
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 616
Met Thr His Ala Lys Lys Ile Pro Phe Pro Val Leu Lys Arg Ser Thr 
1               5                   10                  15      


Leu Arg Lys Ala Arg Gln Arg Ile Ala Ala Gly Ser Ile Thr Ala Gly 
            20                  25                  30          


Glu Arg Pro Phe Asn Ser Thr Val Thr Arg Val Val Pro Val Lys Asp 
        35                  40                  45              


Pro Val Ser Asp Gln Val Trp Ala Val Ala Arg Glu Ala Ala Met Thr 
    50                  55                  60                  


Leu Arg Gly Phe Gly Gln Gly Ser Leu Phe Asp Met Leu Ile His Leu 
65                  70                  75                  80  


His Ala Asp Gly Phe Arg Leu Phe Pro Ser Gly Arg Glu Arg Glu Ala 
                85                  90                  95      


Phe Phe Leu Lys Asp Leu Phe Asp Pro Thr Glu Phe Asp Asp Gly Ala 
            100                 105                 110         


Arg Arg Ala Phe Gly Asp Val Met Pro Gly Phe Thr Ala Asn Ser Leu 
        115                 120                 125             


Arg Glu Ile Leu Gly Ala Pro Ala Arg Lys Cys Gly Lys Val Thr Ser 
    130                 135                 140                 


Val Glu Ile Leu Leu Pro Arg Leu Ser Lys Gly Leu Gly Val Lys Lys 
145                 150                 155                 160 


Ser Ala Ala Pro Pro Glu Val Leu Ser Ser Leu Ala Ala Ala Leu Cys 
                165                 170                 175     


Glu Ala Phe Pro Thr Trp Ser Leu Leu Thr Ala Val Asp Gly Gly Val 
            180                 185                 190         


Gly Lys Val Ile Asp Asp Val Leu Arg Thr His Gly Ser Arg Leu Pro 
        195                 200                 205             


Ser Leu Glu Lys Ala Trp Ser Thr Asn Leu Pro Glu Val Pro Lys Gly 
    210                 215                 220                 


Leu Gly Val Pro Thr Leu Ala Phe Asp Asp Gln Ala Pro Ala Gln Ser 
225                 230                 235                 240 


Glu Gln Thr Pro Thr Gly Arg Phe Ala Gly Val Val Ala Arg Tyr Leu 
                245                 250                 255     


Ala Glu Thr Phe Ala Ser Asn Pro Glu Ala Thr Ala Gly Asp Ala Ser 
            260                 265                 270         


Lys Ala Val Gln Ala Lys Val Thr Thr Pro Asn Gly Asn Ala Leu Ser 
        275                 280                 285             


Trp Leu Phe Ala Val Gly Arg Arg Ala Met Cys Ser Thr Thr Leu Asp 
    290                 295                 300                 


Glu Leu Ala Ile Gly Leu Asn Ile Thr Ser Pro Arg Gly Arg His Ala 
305                 310                 315                 320 


Leu Ser Ser Leu Lys Glu Arg Met Met Ala Leu Pro Ala Leu Ser Val 
                325                 330                 335     


Leu Gly Glu Arg Ala Tyr Pro Asp Ser Arg Ala Thr Leu Gln Gly Thr 
            340                 345                 350         


Val Asp Ser Leu Ile Ala Asn Tyr Val Asn Arg Leu Phe Glu Leu Ser 
        355                 360                 365             


Ser Ser Ala Thr Ser Ile Ala Gln Thr Lys Leu Ile Leu Pro Ala Ala 
    370                 375                 380                 


Ile Gln Gly Asp Thr Ala Val Phe Asp Gly Met Pro Phe Ser Ala Glu 
385                 390                 395                 400 


Asp Val Gly Ala Leu Phe Glu Gln Leu Pro Ser Glu Ile Ala Lys Leu 
                405                 410                 415     


Glu His Ala Val Lys Val Leu Val Gly Lys Glu Arg Thr Ser Thr Leu 
            420                 425                 430         


Gly Tyr Gln Lys Ala Val Asp Asp Val Asp Glu Phe Gly Val Trp Ala 
        435                 440                 445             


Ser Ser Val Asp Ala Val Ile Gly Gln Ile Asn Ala Arg Leu Lys Thr 
    450                 455                 460                 


Leu Glu Arg Ala Gln Glu Pro Leu Gly Lys Leu Met Gly Asp Gly Lys 
465                 470                 475                 480 


Leu Lys Arg Leu Val Asn Ile His Glu Pro Glu Gly Pro Ala Val Glu 
                485                 490                 495     


Ile Ile Pro Val Leu Asp Gln Glu Leu Gln Asp Val Leu Thr Ser Cys 
            500                 505                 510         


Arg Thr Ala Phe Ala Asp Leu Glu Ala Arg Tyr Pro Met Thr Val Ala 
        515                 520                 525             


Lys Ala Gln Arg His Ala Glu Ala Glu Val Arg Asn Ala Leu Glu Leu 
    530                 535                 540                 


Ala Ser Arg Lys Glu Gly Gly Leu Ser Leu Ala Ser Ala Asp Val Pro 
545                 550                 555                 560 


Ala Leu Ala Lys Arg Lys Ile Leu Glu Pro Ile Ile Ser Ile Ala Arg 
                565                 570                 575     


Arg Ser Ser Pro Ala Met Ala Thr Ala Val Leu Thr Glu Cys Leu Arg 
            580                 585                 590         


Gln Lys Leu Ile Val Lys Gly Thr Gly Ser Glu Arg Ser Leu Arg Gly 
        595                 600                 605             


Tyr Val Leu Ser Gly Glu Gln Val Ile Tyr Ala His Pro Leu Ser Arg 
    610                 615                 620                 


Arg Arg Ser Ile Val Arg Leu Asp Arg Glu Gly Leu Gln Asn Phe Asp 
625                 630                 635                 640 


Ala Leu Glu Phe Leu Asp Ala Leu Gln Lys Asp Ala Thr Gln Arg Thr 
                645                 650                 655     


Asn Val Arg Glu Ser Leu Ile Val Glu Met Ala Arg Gln Ser Leu Leu 
            660                 665                 670         


Leu Ser Ala Leu Pro Asp Arg Ile Glu Ile Gly Ala Ile Ser Trp Gln 
        675                 680                 685             


Thr Pro Ser Gln Asn Gln His Ala Pro Trp Ala Asn Leu Arg Pro Val 
    690                 695                 700                 


Asn Gly Thr Val Gly Arg Ser Glu Thr Ile Lys Ser Phe Thr Ala Val 
705                 710                 715                 720 


Phe His Ser Arg Ile Ser Gly Leu Leu Tyr Arg Leu Asn Arg Gln Lys 
                725                 730                 735     


Phe Met Glu Lys Tyr Asp Leu Arg Cys Phe Ile Gly Ser Thr Leu Leu 
            740                 745                 750         


Phe Ser Pro Lys Asn Ala Asp Trp Ala Pro Pro Pro Gln Tyr Arg His 
        755                 760                 765             


Gly Arg Phe Ser Ala Leu Leu Ala Arg Ser Asp Phe Pro Trp Glu Gly 
    770                 775                 780                 


Ala Glu Gly Thr His Ala Asn Ala Val Arg Leu Ala Lys Phe Leu Ile 
785                 790                 795                 800 


Asp Glu Thr Arg Asn Ala Thr Asp Leu Gln Gln Ala Ile Ala Ala Lys 
                805                 810                 815     


Ala Leu Leu Ala Gln Leu Pro His Asp Trp Val Val Cys Cys Asp Phe 
            820                 825                 830         


Asp Gly Ala Pro Ser Tyr Glu Gly Ala Phe Val Ser Ala Gly Glu Val 
        835                 840                 845             


Ser Ala Trp Ala Lys Arg Ser Gly Tyr Leu Leu Thr Pro Pro Arg His 
    850                 855                 860                 


Phe Ala Gly Ala Phe Leu Glu Gly Phe Lys Ser Thr Lys Ile Ser Pro 
865                 870                 875                 880 


His Gly Leu Thr Phe Glu Arg Met Leu Glu Arg Asp Gly Asp Ser Val 
                885                 890                 895     


Ile Glu Thr Gly Arg Arg Val Thr Ala Ala Phe Pro Ile Thr Gln Glu 
            900                 905                 910         


Val Ala Pro Ala Ala Gln Pro Trp Lys Pro Arg His Leu Ala Gly Leu 
        915                 920                 925             


Asp Leu Gly Glu Ala Gly Leu Gly Val Cys Leu Lys Asn Leu Asp Asn 
    930                 935                 940                 


Gly His Glu Gln Thr Leu Leu Leu Lys Thr Arg Lys Thr Arg Leu Leu 
945                 950                 955                 960 


Ala His Ser Ala Glu His Tyr Arg Arg Lys Asp Gln Pro Arg Gln Val 
                965                 970                 975     


Phe Arg Lys Gln Tyr Asn Gln Ser Ser Glu Asn Ala Ile Lys Ala Ala 
            980                 985                 990         


Ile Gly Glu Val Cys Gly Leu Ile  Asp Asn Leu Ile Ala  Arg Tyr Asp 
        995                 1000                 1005             


Ala Val  Pro Val Phe Glu Ser  Gln Ala Ala Ala Ala  Arg Gly Ser 
    1010                 1015                 1020             


Asn Arg  Met Val Ala Arg Val  Tyr Ala Gly Val Leu  Gln Arg Tyr 
    1025                 1030                 1035             


Thr Tyr  Val Val Gly Asn Gly  Ala Ala Asp Ala Thr  Arg Thr Ser 
    1040                 1045                 1050             


His Trp  Leu Gly Ala Asn Arg  Trp Ser Tyr Ser Phe  Gly Ala Asp 
    1055                 1060                 1065             


Val Ile  Pro Lys Val Arg Asp  Leu Ser Pro Glu Val  Leu Arg Ser 
    1070                 1075                 1080             


Ile Lys  Lys Pro Glu Asn Val  Phe Arg Asp Ala Leu  Gly Phe Pro 
    1085                 1090                 1095             


Gly Val  Leu Ala Asn Ala Trp  Arg Thr Ser Met Ile  Cys Ser Val 
    1100                 1105                 1110             


Cys Gly  Thr Asp Pro Ile Gly  Ala Leu Glu Glu Ala  Ile Ala Ala 
    1115                 1120                 1125             


Asn Gln  Ile Ser Phe Val Thr  Asp Asn Glu Gly Glu  Gly Ser Leu 
    1130                 1135                 1140             


Asp Leu  Gly Asp Gly Arg Lys  Val Thr Leu Arg Val  Glu Val Pro 
    1145                 1150                 1155             


Thr Ser  Ser Ala Leu Thr Lys  Arg Glu Ala Ser Arg  Arg Lys Arg 
    1160                 1165                 1170             


Arg Ala  Pro Trp Glu Ala Lys  Val Gly Thr Val Trp  Thr Leu Thr 
    1175                 1180                 1185             


Arg Lys  Ser His Arg Asp Asp  Leu Leu Thr Thr Ile  Arg Arg Ser 
    1190                 1195                 1200             


Leu Arg  Arg Pro Ser Ser Thr  Phe Gln Gly Ser Thr  Thr Lys Gln 
    1205                 1210                 1215             


Trp Glu  Phe His Cys Pro Cys  Cys Gly Gln Ile Gln  Gln Ala Asp 
    1220                 1225                 1230             


Val Asn  Ala Ala Ser Asn Leu  Val Arg Arg Tyr Phe  Val Arg Ala 
    1235                 1240                 1245             


Ser Asp  Asn Ala Arg Ala Arg  Gln His Trp Ala Asp  Asp Ser Lys 
    1250                 1255                 1260             


Arg Leu  Ala Phe Ile Ala Ser  Met Gly Pro Asp Arg  Ser Ala Arg 
    1265                 1270                 1275             


Glu Glu  Lys Val Ser 
    1280             


<210> 617
<211> 1413
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 617
Met Asn Arg Ile Tyr Gln Gly Arg Val Thr Lys Val Glu Lys Leu Lys 
1               5                   10                  15      


Asn Gly Lys Ser Pro Asp Asp Arg Glu Glu Leu Lys Asp Trp Gln Thr 
            20                  25                  30          


Ala Leu Trp Arg His His Glu Leu Phe Gln Asp Ala Val Ser Tyr Tyr 
        35                  40                  45              


Thr Leu Ala Leu Ala Ala Met Ala Glu Gly Leu Pro Asp Lys His Pro 
    50                  55                  60                  


Ile Asn Val Leu Arg Lys Arg Met Glu Glu Ala Trp Glu Glu Phe Pro 
65                  70                  75                  80  


Arg Lys Thr Val Thr Pro Ala Lys Asn Leu Arg Asp Ser Val Arg Pro 
                85                  90                  95      


Trp Leu Gly Leu Ser Glu Ser Ala Ser Phe Gly Asp Ala Leu Lys Lys 
            100                 105                 110         


Ile Leu Pro Pro Ala Pro Glu Asn Lys Glu Val Arg Ala Leu Ala Val 
        115                 120                 125             


Ala Leu Leu Ala Glu Lys Ala Arg Thr Leu Lys Pro Gln Lys Thr Ser 
    130                 135                 140                 


Ala Ser Tyr Trp Gly Arg Phe Cys Asp Asp Leu Lys Lys Lys Pro Asn 
145                 150                 155                 160 


Trp Asp Tyr Ser Glu Glu Glu Leu Ala Arg Lys Thr Gly Ser Gly Asp 
                165                 170                 175     


Trp Val Ala Gly Leu Trp Ser Glu Asp Ala Leu Asn Lys Ile Asp Glu 
            180                 185                 190         


Leu Ala Lys Ser Leu Lys Leu Ser Ser Leu Val Lys Cys Val Pro Asp 
        195                 200                 205             


Gly Gln Ile Asn Pro Glu Gly Ala Arg Asn Leu Val Lys Glu Ala Leu 
    210                 215                 220                 


Asp His Leu Glu Gly Val Ser Asn Gly Thr Lys Lys Glu Lys Asn Asp 
225                 230                 235                 240 


Pro Gly Pro Ala Lys Lys Thr Asn Asn Trp Leu Arg Gln His Ala Ser 
                245                 250                 255     


Asp Val Arg Asn Phe Ile His Lys Asn Lys Asn Gln Phe Ser Ser Leu 
            260                 265                 270         


Pro Asn Gly Arg Leu Ile Thr Glu Arg Ala Arg Gly Gly Gly Ile Asn 
        275                 280                 285             


Ile Asn Lys Thr Tyr Ala Gly Val Leu Phe Lys Ala Phe Pro Cys Pro 
    290                 295                 300                 


Phe Thr Phe Asp Tyr Val Arg Ala Ala Val Pro Glu Pro Lys Val Lys 
305                 310                 315                 320 


Lys Val Asp Gln Glu Lys Lys Ser Glu Gln Ser Ala Thr Trp Thr Glu 
                325                 330                 335     


Leu Glu Lys Arg Ile Leu Arg Ile Gly Asp Asp Pro Ile Glu Leu Ala 
            340                 345                 350         


Arg Lys Asn Asn Lys Pro Ile Phe Lys Ala Phe Thr Ala Leu Glu Lys 
        355                 360                 365             


Trp Ser Asp Gln Asn Ser Lys Ser Cys Trp Ser Asp Phe Asp Lys Cys 
    370                 375                 380                 


Ala Phe Glu Glu Ala Leu Lys Thr Leu Asn Gln Phe Asn Gln Lys Thr 
385                 390                 395                 400 


Glu Glu Arg Glu Lys Arg Arg Ser Glu Ala Glu Ala Glu Leu Lys Tyr 
                405                 410                 415     


Met Met Asp Glu Asn Pro Glu Trp Lys Pro Lys Lys Glu Thr Glu Gly 
            420                 425                 430         


Asp Asp Val Arg Glu Val Pro Ile Leu Lys Gly Asp Pro Arg Tyr Glu 
        435                 440                 445             


Lys Leu Val Lys Leu Phe Gly Asp Leu Asp Glu Glu Gly Ser Glu His 
    450                 455                 460                 


Ala Thr Gly Lys Ile Tyr Gly Pro Ser Arg Ala Ser Leu Arg Gly Phe 
465                 470                 475                 480 


Gly Lys Leu Arg Asn Glu Trp Val Asp Leu Phe Thr Lys Ala Asn Asp 
                485                 490                 495     


Asn Pro Arg Glu Gln Asp Leu Gln Lys Ala Val Thr Gly Phe Gln Arg 
            500                 505                 510         


Glu His Lys Leu Asp Met Gly Tyr Thr Ala Phe Phe Leu Lys Leu Cys 
        515                 520                 525             


Glu Arg Asp Tyr Trp Asp Ile Trp Arg Asp Asp Thr Glu Val Glu Val 
    530                 535                 540                 


Lys Lys Ile Arg Glu Lys Arg Trp Val Lys Ser Val Val Tyr Ala Ala 
545                 550                 555                 560 


Ala Asp Thr Arg Glu Leu Ala Glu Glu Leu Glu Arg Leu Gln Glu Pro 
                565                 570                 575     


Val Arg Tyr Thr Pro Ala Glu Pro Gln Phe Ser Arg Arg Leu Phe Met 
            580                 585                 590         


Phe Ser Asp Ile Lys Gly Lys Gln Gly Ala Lys His Ile Arg Glu Gly 
        595                 600                 605             


Leu Val Glu Val Ser Leu Ala Val Lys Asp Gln Ser Gly Lys Tyr Gly 
    610                 615                 620                 


Thr Cys Arg Val Arg Leu His Tyr Ser Ala Pro Arg Leu Ile Arg Asp 
625                 630                 635                 640 


His Leu Ser Asp Gly Ser Ser Ser Met Trp Leu Gln Pro Met Met Ala 
                645                 650                 655     


Ala Leu Gly Leu Ser Ser Asp Ala Arg Gly Cys Phe Thr Arg Asp Ser 
            660                 665                 670         


Lys Gly Asn Val Lys Glu Pro Ala Val Ala Leu Met Ser Asp Phe Val 
        675                 680                 685             


Gly Arg Lys Arg Glu Leu Arg Met Leu Leu Asn Phe Pro Val Asp Leu 
    690                 695                 700                 


Asp Ile Ser Lys Leu Glu Glu Asn Ile Gly Lys Lys Ala Arg Trp Glu 
705                 710                 715                 720 


Lys Gln Met Asn Thr Ala Tyr Glu Lys Asn Lys Leu Lys Gln Arg Phe 
                725                 730                 735     


His Leu Ile Trp Pro Gly Met Glu Leu Lys Glu Thr Gln Glu Pro Gly 
            740                 745                 750         


Gln Phe Trp Trp Asp Asn Pro Thr Ile Gln Lys Glu Gly Met Tyr Cys 
        755                 760                 765             


Leu Ala Ile Asp Leu Ser Gln Arg Arg Ala Ala Asp Tyr Ala Leu Leu 
    770                 775                 780                 


His Ala Gly Val Asn Arg Asp Ser Lys Thr Phe Val Glu Leu Gly Gln 
785                 790                 795                 800 


Ala Gly Gly Gln Ser Trp Phe Thr Lys Leu Cys Ala Ala Gly Ser Leu 
                805                 810                 815     


Arg Leu Pro Gly Glu Asp Thr Glu Val Ile Arg Glu Gly Lys Arg Gln 
            820                 825                 830         


Ile Glu Leu Ser Gly Lys Lys Gly Arg Asn Ala Thr Gln Ser Glu Tyr 
        835                 840                 845             


Asp Gln Ala Ile Ala Leu Ala Lys Gln Leu Leu His Asn Glu Asn Ser 
    850                 855                 860                 


Ala Glu Leu Glu Ser Ala Ala Arg Asp Trp Leu Gly Asp Asn Ala Lys 
865                 870                 875                 880 


Arg Phe Ser Phe Pro Glu Gln Asn Asp Lys Leu Ile Asp Leu Tyr Tyr 
                885                 890                 895     


Gly Ala Leu Ser Arg Tyr Lys Thr Trp Leu Arg Trp Ser Trp Arg Leu 
            900                 905                 910         


Thr Glu Gln His Lys Glu Leu Trp Asp Lys Thr Leu Asp Glu Ile Arg 
        915                 920                 925             


Lys Val Pro Tyr Phe Ala Ser Trp Gly Glu Leu Ala Gly Asn Gly Thr 
    930                 935                 940                 


Asn Glu Ala Thr Val Gln Gln Leu Gln Lys Leu Ile Ala Asp Ala Ala 
945                 950                 955                 960 


Val Asp Leu Arg Asn Phe Leu Glu Lys Ala Leu Leu His Ile Ala Tyr 
                965                 970                 975     


Arg Ala Leu Pro Leu Arg Glu Asn Thr Trp Arg Trp Ile Glu Asn Gly 
            980                 985                 990         


Lys Asp Gly Lys Gly Lys Pro Leu  His Leu Leu Val Ser  Asp Gly Gln 
        995                 1000                 1005             


Ser Pro  Ala Glu Ile Pro Trp  Leu Arg Gly Gln Arg  Gly Leu Ser 
    1010                 1015                 1020             


Ile Ala  Arg Ile Glu Gln Leu  Glu Asn Phe Arg Arg  Ala Val Leu 
    1025                 1030                 1035             


Ser Leu  Asn Arg Leu Leu Arg  His Glu Ile Gly Thr  Lys Pro Glu 
    1040                 1045                 1050             


Phe Gly  Ser Ser Thr Cys Gly  Glu Ser Leu Pro Asp  Pro Cys Pro 
    1055                 1060                 1065             


Asp Leu  Thr Asp Lys Ile Val  Arg Leu Lys Glu Glu  Arg Val Asn 
    1070                 1075                 1080             


Gln Thr  Ala His Leu Ile Ile  Ala Gln Ser Leu Gly  Val Arg Leu 
    1085                 1090                 1095             


Lys Gly  His Ser Leu Phe Thr  Glu Glu Arg Glu Lys  Ala Asp Met 
    1100                 1105                 1110             


His Gly  Glu His Glu Val Ile  Pro Gly Arg Ser Pro  Val Asp Phe 
    1115                 1120                 1125             


Val Val  Leu Glu Asp Leu Ser  Arg Tyr Thr Thr Asp  Lys Ser Arg 
    1130                 1135                 1140             


Ser Arg  Ser Glu Asn Ser Arg  Leu Met Lys Trp Cys  His Arg Lys 
    1145                 1150                 1155             


Ile Asn  Glu Lys Val Lys Leu  Leu Ala Glu Pro Phe  Gly Ile Pro 
    1160                 1165                 1170             


Val Ile  Glu Val Phe Ala Ser  Tyr Ser Ser Lys Phe  Asp Ala Arg 
    1175                 1180                 1185             


Thr Gly  Ala Pro Gly Phe Arg  Ala Val Glu Val Thr  Ser Glu Asp 
    1190                 1195                 1200             


Arg Pro  Phe Trp Arg Lys Thr  Ile Glu Lys Gln Ser  Val Ala Arg 
    1205                 1210                 1215             


Glu Val  Phe Asp Cys Leu Asp  Asn Leu Val Gly Lys  Gly Leu Asn 
    1220                 1225                 1230             


Gly Ile  His Leu Val Leu Pro  Gln Asn Gly Gly Pro  Leu Phe Ile 
    1235                 1240                 1245             


Ala Ala  Val Lys Glu Asp Gln  Pro Leu Pro Ala Ile  Arg Gln Ala 
    1250                 1255                 1260             


Asp Ile  Asn Ala Ala Val Asn  Ile Gly Leu Arg Ala  Ile Ala Gly 
    1265                 1270                 1275             


Pro Ser  Cys Tyr His Ala His  Pro Lys Val Arg Leu  Ile Lys Gly 
    1280                 1285                 1290             


Glu Ser  Gly Thr Asp Lys Gly  Lys Trp Leu Pro Arg  Lys Gly Lys 
    1295                 1300                 1305             


Glu Ala  Asn Lys Arg Glu Asn  Ala Gln Phe Gly Asn  Val Asp Leu 
    1310                 1315                 1320             


Asp Leu  Glu Val Lys Phe Asn  Arg Leu Asp Ile Asp  Ser Asp Val 
    1325                 1330                 1335             


Leu Lys  Gly Asp Asn Thr Asn  Leu Phe His Asp Pro  Leu Asn Ile 
    1340                 1345                 1350             


Ala Cys  Tyr Gly Phe Ala Thr  Ile Gln Asn Leu Gln  His Pro Phe 
    1355                 1360                 1365             


Leu Ala  His Ala Ser Ala Val  Phe Ser Arg Gln Lys  Gly Ala Val 
    1370                 1375                 1380             


Ala Arg  Leu Gln Trp Glu Val  Cys Arg Ala Ile Asn  Ser Arg Arg 
    1385                 1390                 1395             


Leu Glu  Ala Trp Gln Lys Lys  Ala Glu Lys Ala Ala  Val Lys Arg 
    1400                 1405                 1410             


<210> 618
<211> 1408
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 618
Met Ser His Glu Leu Ala Glu Gln Pro Ser Pro Pro Lys Asn Lys Glu 
1               5                   10                  15      


Pro Thr Cys Glu Glu Ser Asp Ala Ile Arg Lys Asn Arg Arg Ile Leu 
            20                  25                  30          


Leu Ala Leu Ser Trp Leu Ser Val Glu Asp Asp Cys Ser Ala Pro Thr 
        35                  40                  45              


Gly Thr Phe Arg Val Ala Ser Gly Lys Asp Ser Glu Ala Glu Arg Lys 
    50                  55                  60                  


Asn Lys Val Leu Thr Ala Phe Arg Ser Ile Leu Thr Ala Arg Arg Met 
65                  70                  75                  80  


Arg Ser Gln Asp Val Glu Ser Trp Ile Ala Asp Cys Ala Ala Ser Leu 
                85                  90                  95      


Ser Ala Lys Ile Arg Glu Asp Ala Val Trp Ile Asn Arg Ser Ala Cys 
            100                 105                 110         


Phe Asp Gln Arg Ala Leu Asp Leu Lys Val Leu Ser Arg Glu Tyr Ala 
        115                 120                 125             


Lys Ala Ala Val Met Ser Phe Phe Gly Pro Leu Asp Glu Tyr Phe Lys 
    130                 135                 140                 


Leu Pro Asp Glu Ala Asp Asp Thr Lys Pro Ala Val Gly Gly Asp Gly 
145                 150                 155                 160 


Pro Asp Phe Arg Thr Leu Ala Arg Gln Trp Val Ser Thr Asn Phe Gly 
                165                 170                 175     


Thr Gly Lys Lys Ser Asp Ser Glu Ala Ile Ala Gln Asn Leu Arg Lys 
            180                 185                 190         


Leu Ala Asp Ala Asn Leu Ala Pro Phe Ser Gly Lys Pro Lys Ala Ala 
        195                 200                 205             


Leu Ile Ala His Leu Ser Val Glu Leu Asp Gly Ser Thr Ala Asp Ile 
    210                 215                 220                 


Asp Gly Leu Cys Arg Ala Ile Gly Trp Asn Thr Gly Arg Pro Ser Lys 
225                 230                 235                 240 


Gly Arg Val Ala Ile Glu Arg Leu Pro Asp Pro Pro Thr Glu Thr Ser 
                245                 250                 255     


Ile Gln Thr Met Gln Gln Lys Phe Arg Glu Glu Ala Glu Ala Lys Ala 
            260                 265                 270         


Ser Ser Lys Gly Leu Arg Gln Val Pro Glu Trp Met Pro Ala Phe Gln 
        275                 280                 285             


Lys Ser Ile Glu Arg Asp Cys Gly Met Pro Phe Lys Leu Gly Glu Gly 
    290                 295                 300                 


Arg Asp His Ile Gly Glu Phe Ser Val Met Leu Asp His Ala Ala Arg 
305                 310                 315                 320 


Arg Val Ser Ile Gly His Ser Trp Ile Lys Arg Ala Glu Ala Glu Arg 
                325                 330                 335     


Arg Arg Phe Glu Ala Asp Ala Gln Arg Leu Asn His Ile Pro Ala Ala 
            340                 345                 350         


Ala Lys Asp Trp Leu Asp Gln Phe Val Gln Phe Arg Ser Gly Ser Ser 
        355                 360                 365             


Gly Ala Ala Ala Ala Gly Gly Glu Tyr Arg Ile Arg Arg Arg Ala Ile 
    370                 375                 380                 


Glu Gly Trp Asp Glu Ile Ile Lys Arg Trp Lys Arg Ala Ala Cys Lys 
385                 390                 395                 400 


Ser Pro Glu Asp Arg Val Ala Ala Ala Arg Glu Val Gln Ala Asp Pro 
                405                 410                 415     


Glu Ile Glu Lys Phe Gly Asp Ile Gln Leu Phe Glu Ala Leu Ala Ala 
            420                 425                 430         


Asp Asp Ala Glu Cys Val Trp Arg Gly Asp Gly Asn Gly Thr Pro Asp 
        435                 440                 445             


Pro Leu Lys Asp Tyr Val Ala Ala Thr Asp Ala Leu Asp Lys Met Arg 
    450                 455                 460                 


Arg Phe Lys Val Pro Ala Tyr Arg His Pro Asp Pro Leu Ala His Pro 
465                 470                 475                 480 


Val Phe Gly Asp Phe Gly Asn Ser Arg Gly Asp Ile Arg Phe Ala Val 
                485                 490                 495     


His Glu Ala Ala Lys Ala Thr Arg Gly Thr Lys Arg Ile Ala Lys Asp 
            500                 505                 510         


Gln Lys Glu Trp Ile Arg Glu Arg His Gly Leu Arg Met Gly Leu Trp 
        515                 520                 525             


Asp Gly Gln Ser Val Arg Thr Ala Asp Leu Arg Trp Ser Ser Lys Arg 
    530                 535                 540                 


Leu Val Asp Asp Leu Ala Leu Arg Asn His Val Thr Thr Arg Arg Thr 
545                 550                 555                 560 


Gly Pro Val Ser Arg Ala Asp Arg Leu Gly Arg Ala Ala Ala Gly Leu 
                565                 570                 575     


Gly Ala Asp Glu Ala Ala Cys Val Ala Gly Leu Phe Glu Leu Pro Asp 
            580                 585                 590         


Trp Asn Gly Arg Leu Gln Ala Pro Arg Ala Gln Leu Asp Ala Ile Ala 
        595                 600                 605             


Ala Cys Val Ala Ala Asn Gly Gly Lys Trp Asp Asp Lys Ala Arg Lys 
    610                 615                 620                 


Leu Arg Asp Arg Ile Glu Trp Leu Val Ser Phe Ser Ala Lys Leu Glu 
625                 630                 635                 640 


Cys Cys Gly Pro Phe Met Glu Tyr Ala Ser Gln Asn Gly Ile Gln Pro 
                645                 650                 655     


Asn Gly Lys Gly Glu Tyr Tyr Pro His Ala Glu Arg Asn Lys Gly Arg 
            660                 665                 670         


Thr Gly His Ala Lys Leu Ile Leu Ser Arg Leu Pro Gly Leu Arg Val 
        675                 680                 685             


Leu Ala Val Asp Leu Gly His Arg Phe Ala Ala Ala Cys Ala Val Trp 
    690                 695                 700                 


Glu Ala Leu Ser Lys Ile Ala Phe Asp Ala Glu Thr Lys Gly Arg Glu 
705                 710                 715                 720 


Val Val Ser Gly Gly Arg Ala Ala Asp Asp Leu Tyr Cys His Thr Arg 
                725                 730                 735     


His Leu Asp Cys Ala Gly Lys Ala Arg Thr Thr Ile Tyr Arg Arg Ile 
            740                 745                 750         


Gly Pro Asp Lys Leu Pro Asp Gly Ser Asp His Pro Ala Pro Trp Ala 
        755                 760                 765             


Arg Leu Asp Arg Gln Phe Leu Ile Lys Leu Gln Gly Glu Glu Arg Pro 
    770                 775                 780                 


Ala Arg Ala Ala Gly Pro Ala Glu Thr Ala Ala Val Gln Gln Ile Glu 
785                 790                 795                 800 


Thr Asp Leu Gly Arg Ala Arg Gly Gln Glu Asp Leu Pro Pro Arg Pro 
                805                 810                 815     


Val Asp Ser Leu Met Arg Glu Ala Val Arg Thr Ile Arg Ile Ala Leu 
            820                 825                 830         


Arg Arg His Gly Asp Ala Ala Arg Ile Ala Tyr Ala Phe Lys Pro Gly 
        835                 840                 845             


Ala Lys Arg Leu Lys Pro Gly Gly Gly Ala Gln Asp His Thr Pro Glu 
    850                 855                 860                 


Thr His Ala Asp Ala Ile Leu Glu Ala Leu Leu Arg Trp His Glu Leu 
865                 870                 875                 880 


Ala Thr Gly Ala Arg Trp Arg Asp Pro Trp Ala Glu Thr Gln Trp Lys 
                885                 890                 895     


Asp Trp Val Gln Pro His Ile Ser Ala Thr Leu Pro Glu Leu Ala Asn 
            900                 905                 910         


Asp Ala Asp Arg Trp Glu Arg Lys Arg His Arg Ala Ala Leu Glu Gln 
        915                 920                 925             


Val Leu Arg Pro Val Ala Gln Met Leu Ile Gln Arg Pro Thr Asp Ala 
    930                 935                 940                 


Leu His Gln Val Trp Ser Lys His Trp Ala Asp Glu Asp Leu Lys Trp 
945                 950                 955                 960 


Pro Ser Arg Leu Arg Trp Leu Arg Asn Trp Leu Leu Pro Arg Gly Pro 
                965                 970                 975     


Arg Ala Arg Ser Gly Ala Ala Arg Asn Val Gly Gly Leu Ser Leu Leu 
            980                 985                 990         


Arg Ile Ala Thr Leu Arg Glu Leu  Tyr Gln Thr Gln Lys  Ala Tyr Ala 
        995                 1000                 1005             


Met Arg  Pro Glu Pro Asp Asp  Pro Arg Lys Arg Ile  Ala Gly Arg 
    1010                 1015                 1020             


Asn Asp  Asp Arg Tyr Asp Glu  Leu Gly Arg Ser Val  Leu Gln Val 
    1025                 1030                 1035             


Ile Glu  Arg Leu Arg Glu Gln  Arg Val Lys Gln Leu  Ala Ser Arg 
    1040                 1045                 1050             


Ile Val  Glu Ala Ala Leu Gly  Val Gly Arg Ala Lys  Pro Thr Arg 
    1055                 1060                 1065             


Gly Arg  Gln Arg Pro Gln Ser  Arg Val Asp Val Pro  Cys His Ala 
    1070                 1075                 1080             


Val Ile  Ile Glu Ser Leu Arg  Asn Tyr Arg Pro Asp  Glu Leu Gln 
    1085                 1090                 1095             


Thr Arg  Arg Glu Asn Arg Ala  Ile Met Asn Trp Ser  Ala Gly Lys 
    1100                 1105                 1110             


Val Arg  Lys Tyr Leu Glu Glu  Ala Cys Gln Leu His  Gly Leu His 
    1115                 1120                 1125             


Leu Arg  Glu Val Met Pro Asn  Tyr Thr Ser Arg Glu  Asp Ser Arg 
    1130                 1135                 1140             


Thr Gly  Leu Pro Gly Val Arg  Cys Val Asp Val Pro  Val Asp Pro 
    1145                 1150                 1155             


Lys Leu  Gly Lys Pro Lys Ala  Tyr Trp Trp Asn Ser  Val Leu Ser 
    1160                 1165                 1170             


Thr Ala  Arg Lys Lys Ser Ile  Gly Asp Ala Ala Ser  His Asp Lys 
    1175                 1180                 1185             


Gln Gly  Asp Ala Thr Ser Arg  Phe Ile Val Glu Leu  Ala Gly Cys 
    1190                 1195                 1200             


Leu Asp  Arg Leu Lys Ala Asp  Gly Lys Pro Leu Pro  Lys Thr Val 
    1205                 1210                 1215             


Arg Val  Pro Arg Ile Gly Gly  Asp Leu Phe Val Ala  Ala Pro Pro 
    1220                 1225                 1230             


Thr Ser  Cys Thr Ala Pro Ala  His Gln Pro His Pro  Ala Cys Asp 
    1235                 1240                 1245             


Gly Ala  Arg Ala Leu Gln Ala  Asp Leu Asn Ala Ala  Ala Asn Ile 
    1250                 1255                 1260             


Gly Leu  Arg Ala Leu Leu Asp  Pro Asp Phe Pro Ala  Lys Trp Trp 
    1265                 1270                 1275             


Tyr Val  Pro Cys Ile Asp Asp  Gln Arg Gly Leu Ala  Leu Pro Arg 
    1280                 1285                 1290             


Ala Asp  Lys Val Leu Gly Ser  Ala Cys Phe Pro Gly  Asp Pro Ala 
    1295                 1300                 1305             


Thr Phe  Gly Ser Leu Leu Lys  Thr Arg Thr Ala Ala  Gly Pro Ala 
    1310                 1315                 1320             


Val Asp  Gly Gln Ala Ala Pro  Asp Arg Lys Pro Arg  Thr Gly Thr 
    1325                 1330                 1335             


His Arg  Pro Gly Ser Ala Lys  Ser Arg Ser Leu Gly  Asp Gly Lys 
    1340                 1345                 1350             


Ala Thr  Thr Asn Tyr Trp Ser  Asp Arg Ser Ala Arg  Asp Leu Arg 
    1355                 1360                 1365             


Pro Ala  Asp Glu Gly Gly His  Trp Gln Pro Thr Asn  Val Tyr Trp 
    1370                 1375                 1380             


Asn Trp  Val Arg Lys Arg Ala  Leu Leu Gly Leu Tyr  Ser Phe Asn 
    1385                 1390                 1395             


Gly Leu  Ser Pro Pro Ser Asp  Asp Arg Pro 
    1400                 1405             


<210> 619
<211> 1108
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 619
Met Ala Ile Arg Ser Ile Lys Leu Lys Leu Lys Thr Asn Thr Gly Pro 
1               5                   10                  15      


Glu Ala Gln Asn Leu Arg Lys Gly Ile Trp Arg Thr His Arg Leu Leu 
            20                  25                  30          


Asn Glu Gly Val Ala Tyr Tyr Met Asn Met Leu Leu Leu Phe Arg Gln 
        35                  40                  45              


Glu Ser Thr Asp Lys Lys Thr Lys Gln Glu Ile His Glu Glu Leu Ile 
    50                  55                  60                  


Arg His Ile Arg Ala Gln Gln Gln Arg Asn His Ala Asp Glu Lys Thr 
65                  70                  75                  80  


Gln Ala Leu Pro Leu Glu Lys Ala Leu Glu Ala Leu Arg Lys Leu Tyr 
                85                  90                  95      


Glu Leu Leu Val Pro Ser Ser Val Gly Gln Ser Gly Asp Ser Gln Ile 
            100                 105                 110         


Ile Ser Arg Lys Phe Leu Ser Pro Leu Val Asp Pro Asn Ser Glu Gly 
        115                 120                 125             


Gly Lys Gly Thr Ser Lys Ala Gly Ala Lys Pro Ala Trp Gln Lys Lys 
    130                 135                 140                 


Lys Glu Ala Asn Asp Pro Thr Trp Lys Gln Asp Tyr Glu Lys Trp Lys 
145                 150                 155                 160 


Lys Arg Arg Glu Glu Asp Pro Thr Ala Ser Val Ile Thr Thr Leu Glu 
                165                 170                 175     


Glu Tyr Gly Ile Arg Pro Leu Phe Pro Leu Tyr Thr Asn Thr Val Ala 
            180                 185                 190         


Glu Ile Ala Trp Leu Pro Leu Lys Ser Gly Gln Phe Val Arg Thr Trp 
        195                 200                 205             


Asp Arg Asp Met Phe Gln Gln Ala Ile Glu Gly Met Leu Ser Trp Glu 
    210                 215                 220                 


Ser Trp Asn Arg Arg Val Gln Glu Glu Tyr Ala Lys Leu Glu Gly Lys 
225                 230                 235                 240 


Met Ala Gln Leu Asn Glu Gln Leu Glu Gly Gly Glu Glu Trp Ile Arg 
                245                 250                 255     


Leu Leu Glu Gln Tyr Glu Glu Lys Arg Glu Gln Glu Leu Arg Glu Asn 
            260                 265                 270         


Met Thr Ala Ala Asn Asp Lys Phe Arg Ile Thr Lys Arg Gln Met Lys 
        275                 280                 285             


Gly Trp Lys Glu Leu Tyr Glu Val Trp Ser Thr Phe Leu Pro Ser Ala 
    290                 295                 300                 


Ser Gln Glu Gln Tyr Lys Glu Ala Ile Lys Arg Val Gln Gln Arg Leu 
305                 310                 315                 320 


Arg Gly Lys Phe Gly Asp Phe His Phe Phe Gln Tyr Leu Ser Glu Glu 
                325                 330                 335     


Glu Asn Arg Leu Ile Trp Lys Gly Asn Pro Gln Arg Ile His Tyr Phe 
            340                 345                 350         


Val Ala Arg Asn Glu Leu Thr Lys Lys Leu Glu Lys Ala Lys Gln Ser 
        355                 360                 365             


Ala Arg Arg Thr Leu Pro Asp Ala Asn Lys His Pro Leu Trp Val Arg 
    370                 375                 380                 


Tyr Asp Ala Arg Gly Gly Asn Leu Gln Asp Tyr Tyr Leu Thr Ala Glu 
385                 390                 395                 400 


Ser Asp Lys Pro Arg Ser Arg Arg Phe Val Thr Phe Ser Gln Leu Ile 
                405                 410                 415     


Trp Pro Ser Glu Ser Gly Trp Leu Glu Lys Lys Asp Val Gln Ala Glu 
            420                 425                 430         


Leu Ala Leu Ser Arg Gln Phe Tyr Gln Gln Val Thr Phe Leu Lys Asn 
        435                 440                 445             


Asp Lys Gly Lys Gln Glu Ile Glu Phe Lys Asp Lys Gly Ser Gly Thr 
    450                 455                 460                 


Thr Phe Ser Gly His Leu Gly Gly Ala Lys Leu Gln Leu Glu Arg Ser 
465                 470                 475                 480 


Val Leu Glu Asn Lys Glu Arg Lys Phe Glu Glu Gly Glu Ile Gly Lys 
                485                 490                 495     


Ala Tyr Leu Asn Val Ala Ile Asp Phe Lys Pro Leu Gln Glu Val Lys 
            500                 505                 510         


Asn Gly Arg Val Gln Ala Pro Tyr Gly Gln Val Leu Gln Leu Ile Arg 
        515                 520                 525             


Leu Pro Asn Ala Phe Pro Lys Val Arg Thr Tyr Lys Ser Glu Glu Leu 
    530                 535                 540                 


Val Glu Trp Ile Lys Ala Ser Pro Gln His Leu Ser Gly Val Glu Ser 
545                 550                 555                 560 


Leu Ala Ser Gly Phe Arg Val Met Ser Ile Asp Leu Gly Leu Arg Ala 
                565                 570                 575     


Ala Ala Ala Thr Ser Ile Phe Ser Val Glu Glu Ser Ser Asp Lys Asn 
            580                 585                 590         


Ala Thr Lys Leu Ala Tyr Trp Ile Glu Gly Thr Pro Leu Val Ala Val 
        595                 600                 605             


His Gln Arg Ser Tyr Met Leu Arg Leu Pro Gly Glu Gln Val Glu Gln 
    610                 615                 620                 


His Val Trp Glu Lys Arg Asp Glu Arg Gly Asp Gln His Lys Arg Val 
625                 630                 635                 640 


Arg Phe Gln Ile Arg Arg Leu Ala Glu Ile Ile Arg Leu Ala Asn Lys 
                645                 650                 655     


Gln Tyr Gly Asp Arg Trp Asp Glu Leu Asn Arg Leu Asp Glu Ala Val 
            660                 665                 670         


Ser Lys Glu Lys Ser Pro Leu Asp Gln Ala Asp Arg Thr Phe Trp Glu 
        675                 680                 685             


Gly Ile Val Ser Asp Leu Thr Thr Ala Leu Pro Leu Asn Asp Ala Asp 
    690                 695                 700                 


Trp Thr Glu Ala Val Val Gln Ile His Arg Lys Ala Glu Leu Tyr Val 
705                 710                 715                 720 


Gly Lys Val Val Gln Ala Trp Arg Lys Arg Phe Asn Ala Asp Glu Arg 
                725                 730                 735     


Lys Gly Ile Ala Gly Leu Ser Met Trp Ser Ile Glu Glu Leu Asp Gly 
            740                 745                 750         


Leu Arg Lys Leu Leu Ile Ser Trp Ser Arg Arg Thr Arg Asn Pro Gln 
        755                 760                 765             


Glu Val Asn Arg Phe Glu Pro Glu His Thr Gly His Lys Arg Leu Leu 
    770                 775                 780                 


Thr His Ile Gln Asn Val Lys Lys Asp Arg Leu Lys Gln Val Ser His 
785                 790                 795                 800 


Ala Ile Val Met Thr Ala Leu Gly Tyr Ile Tyr Asp Glu Lys Lys Gln 
                805                 810                 815     


Lys Trp Cys Ala Lys Tyr Pro Ala Cys Gln Val Ile Leu Phe Glu Asn 
            820                 825                 830         


Leu Ser Gln Tyr Arg Ser Asn Leu Asp Arg Ser Ala Lys Glu Asn Ser 
        835                 840                 845             


Thr Leu Met Lys Trp Ala His Arg Ser Ile Pro Lys Tyr Val His Met 
    850                 855                 860                 


Gln Ala Glu Pro Tyr Gly Ile Gln Ile Gly Asp Val Arg Ala Glu Tyr 
865                 870                 875                 880 


Ser Ser Arg Tyr Tyr Ala Lys Thr Gly Thr Pro Gly Ile Arg Cys Lys 
                885                 890                 895     


Lys Leu Arg Glu His Asp Val Lys Gly Trp Arg Leu Asp His Leu Lys 
            900                 905                 910         


Lys Arg Leu Val Asn Glu Gln Phe Leu Thr Glu Ala Gln Val Glu Gln 
        915                 920                 925             


Leu Lys Ala Gly Asp Ile Ile Pro Asp Asp Ser Gly Glu Leu Phe Met 
    930                 935                 940                 


Thr Met Thr Asp Gly Ser Gly Gly Lys Glu Ile Val Phe Leu Gln Ala 
945                 950                 955                 960 


Asp Ile Asn Ala Ala Gln Asn Leu Gln Lys Arg Phe Trp Gln Arg Asn 
                965                 970                 975     


Ser Glu Leu Phe Lys Val Ser Cys Arg Val Ile Val Arg Asp Glu Ala 
            980                 985                 990         


Glu Tyr Leu Val Pro Gln Ala Lys  Lys Val Gln Glu Lys  Leu Gly Lys 
        995                 1000                 1005             


Gly Val  Phe Val Lys Lys Ser  Asp Thr Ala Trp Lys  Glu Val Tyr 
    1010                 1015                 1020             


Val Trp  Asp Ser Gln Ala Lys  Leu Lys Gly Lys Thr  Thr Phe Thr 
    1025                 1030                 1035             


Glu Glu  Ser Glu Ser Pro Glu  Gln Leu Glu Asp Leu  Gln Glu Met 
    1040                 1045                 1050             


Ile Glu  Glu Ala Glu Glu Ala  Lys Gly Thr Tyr Arg  Thr Leu Phe 
    1055                 1060                 1065             


Arg Asp  Pro Ser Gly Val Phe  Phe Pro Asp Phe Val  Trp Asn Thr 
    1070                 1075                 1080             


Pro Lys  Asp Phe Trp Gly Glu  Val Lys Arg Lys Leu  Tyr Gly Lys 
    1085                 1090                 1095             


Leu Arg  Glu Arg Leu Leu Thr  Lys Val Arg 
    1100                 1105             


<210> 620
<211> 1364
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 620
Met Asn Arg Ile Tyr Gln Gly Arg Val Thr Lys Val Glu Val Pro Asp 
1               5                   10                  15      


Gly Lys Asp Glu Lys Gly Asn Ile Lys Trp Lys Lys Leu Glu Asn Trp 
            20                  25                  30          


Ser Asp Ile Leu Trp Gln His His Met Leu Phe Gln Asp Ala Val Asn 
        35                  40                  45              


Tyr Tyr Thr Leu Ala Leu Ala Ala Ile Ser Gly Ser Ala Val Gly Ser 
    50                  55                  60                  


Asp Glu Lys Ser Ile Ile Leu Arg Glu Trp Ala Val Gln Val Gln Asn 
65                  70                  75                  80  


Ile Trp Glu Lys Ala Lys Lys Lys Ala Thr Val Phe Glu Gly Pro Gln 
                85                  90                  95      


Lys Arg Leu Thr Ser Ile Leu Gly Leu Glu Gln Asn Ala Ser Phe Asp 
            100                 105                 110         


Ile Ala Ala Lys His Ile Leu Arg Thr Ser Glu Ala Lys Pro Glu Gln 
        115                 120                 125             


Arg Ala Ser Ala Leu Ile Arg Leu Leu Glu Glu Ile Asp Lys Lys Asn 
    130                 135                 140                 


His Asn Val Val Cys Gly Glu Arg Leu Pro Phe Phe Cys Pro Arg Asn 
145                 150                 155                 160 


Ile Gln Ser Lys Arg Ser Pro Thr Ser Lys Ala Val Ser Ser Val Gln 
                165                 170                 175     


Glu Gln Lys Arg Gln Glu Glu Val Arg Arg Phe His Asn Met Gln Pro 
            180                 185                 190         


Glu Glu Val Val Lys Asn Ala Val Thr Leu Asp Ile Ser Leu Phe Lys 
        195                 200                 205             


Ser Ser Pro Lys Ile Val Phe Leu Glu Asp Pro Lys Lys Ala Arg Ala 
    210                 215                 220                 


Glu Leu Leu Lys Gln Phe Asp Asn Ala Cys Lys Lys His Lys Glu Leu 
225                 230                 235                 240 


Val Gly Ile Lys Lys Ala Phe Thr Glu Ser Ile Asp Lys His Gly Ser 
                245                 250                 255     


Ser Leu Lys Val Pro Ala Pro Gly Ser Lys Pro Ser Gly Leu Tyr Pro 
            260                 265                 270         


Ser Ala Ile Val Phe Lys Tyr Phe Pro Val Asp Ile Thr Lys Thr Val 
        275                 280                 285             


Phe Leu Lys Ala Thr Glu Lys Leu Ala Met Gly Lys Asp Arg Glu Val 
    290                 295                 300                 


Thr Asn Asp Pro Ile Ala Asp Ala Arg Val Asn Asp Lys Pro His Phe 
305                 310                 315                 320 


Asp Tyr Phe Thr Asn Ile Ala Leu Ile Arg Glu Lys Glu Lys Asn Arg 
                325                 330                 335     


Ala Ala Trp Phe Glu Phe Asp Leu Ala Ala Phe Ile Glu Ala Ile Met 
            340                 345                 350         


Ser Pro His Arg Phe Tyr Gln Asp Thr Gln Lys Arg Lys Glu Ala Ala 
        355                 360                 365             


Arg Lys Leu Glu Glu Lys Ile Lys Ala Ile Glu Gly Lys Gly Gly Gln 
    370                 375                 380                 


Phe Lys Glu Ser Asp Ser Glu Asp Asp Asp Val Asp Ser Leu Pro Gly 
385                 390                 395                 400 


Phe Glu Gly Asp Thr Arg Ile Asp Leu Leu Arg Lys Leu Val Thr Asp 
                405                 410                 415     


Thr Leu Gly Trp Leu Gly Glu Ser Glu Thr Pro Asp Asn Asn Glu Gly 
            420                 425                 430         


Lys Lys Thr Glu Tyr Ser Ile Ser Glu Arg Thr Leu Arg Ile Phe Pro 
        435                 440                 445             


Asp Ile Gln Lys Gln Trp Ser Glu Leu Ala Glu Lys Gly Glu Thr Thr 
    450                 455                 460                 


Glu Gly Lys Leu Leu Glu Val Leu Lys His Glu Gln Thr Glu His Gln 
465                 470                 475                 480 


Ser Asp Phe Gly Ser Ala Thr Leu Tyr Gln His Leu Ala Lys Pro Glu 
                485                 490                 495     


Phe His Pro Ile Trp Leu Lys Ser Gly Thr Glu Glu Trp His Ala Glu 
            500                 505                 510         


Asn Pro Leu Lys Ala Trp Leu Asn Tyr Lys Glu Leu Gln Tyr Glu Leu 
        515                 520                 525             


Thr Asp Lys Lys Arg Pro Ile His Phe Thr Pro Ala His Pro Val Tyr 
    530                 535                 540                 


Ser Pro Arg Tyr Phe Asp Phe Pro Lys Lys Ser Glu Thr Glu Glu Lys 
545                 550                 555                 560 


Glu Val Ser Lys Asn Thr His Ser Leu Thr Thr Ser Leu Ala Ser Glu 
                565                 570                 575     


His Ile Lys Asn Ser Leu Gln Phe Thr Ala Gly Leu Ile Arg Lys Thr 
            580                 585                 590         


Asn Val Gly Lys Lys Ala Ile Lys Ala Arg Phe Ser Tyr Ser Ala Pro 
        595                 600                 605             


Arg Leu Arg Arg Asp Cys Leu Arg Ser Glu Asn Asn Glu Asn Leu Tyr 
    610                 615                 620                 


Lys Ala Pro Trp Leu Gln Pro Met Met Arg Ala Leu Gly Ile Asp Glu 
625                 630                 635                 640 


Glu Lys Ala Asp Arg Gln Asn Phe Ala Asn Thr Arg Ile Thr Leu Met 
                645                 650                 655     


Ala Lys Gly Leu Asp Asp Ile Gln Leu Gly Phe Pro Val Glu Ala Asn 
            660                 665                 670         


Ser Gln Glu Leu Gln Lys Glu Val Ser Asn Gly Ile Ser Trp Lys Gly 
        675                 680                 685             


Gln Phe Asn Trp Gly Gly Ile Ala Ser Leu Ser Ala Leu Arg Trp Pro 
    690                 695                 700                 


His Glu Lys Lys Pro Lys Asn Pro Pro Glu Gln Pro Trp Trp Gly Ile 
705                 710                 715                 720 


Asp Ser Phe Ser Cys Leu Ala Val Asp Leu Gly Gln Arg Tyr Ala Gly 
                725                 730                 735     


Ala Phe Ala Arg Leu Asp Val Ser Thr Ile Glu Lys Lys Gly Lys Ser 
            740                 745                 750         


Arg Phe Ile Gly Glu Ala Cys Asp Lys Lys Trp Tyr Ala Lys Val Ser 
        755                 760                 765             


Arg Met Gly Leu Leu Arg Leu Pro Gly Glu Asp Val Lys Val Trp Arg 
    770                 775                 780                 


Asp Ala Ser Lys Ile Asp Lys Glu Asn Gly Phe Ala Phe Arg Lys Glu 
785                 790                 795                 800 


Leu Phe Gly Glu Lys Gly Arg Ser Ala Thr Pro Leu Glu Ala Glu Glu 
                805                 810                 815     


Thr Ala Glu Leu Ile Lys Leu Phe Gly Ala Asn Glu Lys Asp Val Met 
            820                 825                 830         


Pro Asp Asn Trp Ser Lys Glu Leu Ser Phe Pro Glu Gln Asn Asp Lys 
        835                 840                 845             


Leu Leu Ile Val Ala Arg Arg Ala Gln Ala Ala Val Ser Arg Leu His 
    850                 855                 860                 


Arg Trp Ala Trp Phe Phe Asp Glu Ala Lys Arg Ser Asp Asp Ala Ile 
865                 870                 875                 880 


Arg Glu Ile Leu Glu Ser Asp Asp Thr Asp Leu Lys Gln Lys Val Asn 
                885                 890                 895     


Lys Asn Glu Ile Glu Lys Val Lys Glu Thr Ile Ile Ser Leu Leu Lys 
            900                 905                 910         


Val Lys Gln Glu Leu Leu Pro Thr Leu Leu Thr Arg Leu Ala Asn Arg 
        915                 920                 925             


Val Leu Pro Leu Arg Gly Arg Ser Trp Glu Trp Lys Lys His His Gln 
    930                 935                 940                 


Lys Asn Asp Gly Phe Ile Leu Asp Gln Thr Gly Lys Ala Met Pro Asn 
945                 950                 955                 960 


Val Leu Ile Arg Gly Gln Arg Gly Leu Ser Met Asp Arg Ile Glu Gln 
                965                 970                 975     


Ile Thr Glu Leu Arg Lys Arg Phe Gln Ala Leu Asn Gln Ser Leu Arg 
            980                 985                 990         


Arg Gln Ile Gly Lys Lys Ala Pro  Ala Lys Arg Asp Asp  Ser Ile Pro 
        995                 1000                 1005             


Asp Cys  Cys Pro Asp Leu Leu  Glu Lys Leu Asp His  Met Lys Glu 
    1010                 1015                 1020             


Gln Arg  Val Asn Gln Thr Ala  His Met Ile Leu Ala  Glu Ala Leu 
    1025                 1030                 1035             


Gly Leu  Lys Leu Ala Glu Pro  Pro Lys Asp Lys Lys  Glu Leu Asn 
    1040                 1045                 1050             


Glu Thr  Cys Asp Met His Gly  Ala Tyr Ala Lys Val  Asp Asn Pro 
    1055                 1060                 1065             


Val Ser  Phe Ile Val Ile Glu  Asp Leu Ser Arg Tyr  Arg Ser Ser 
    1070                 1075                 1080             


Gln Gly  Arg Ser Pro Arg Glu  Asn Ser Arg Leu Met  Lys Trp Cys 
    1085                 1090                 1095             


His Arg  Ala Val Arg Asp Lys  Leu Lys Glu Met Cys  Glu Val Phe 
    1100                 1105                 1110             


Phe Pro  Leu Cys Glu Arg Arg  Lys Ala Gly Ser Ala  Trp Val Ser 
    1115                 1120                 1125             


Leu Pro  Pro Leu Leu Glu Thr  Pro Ala Ala Tyr Ser  Ser Arg Phe 
    1130                 1135                 1140             


Cys Ser  Arg Ser Gly Val Ala  Gly Phe Arg Ala Val  Glu Val Ile 
    1145                 1150                 1155             


Pro Gly  Phe Glu Leu Lys Tyr  Pro Trp Ser Trp Leu  Lys Asp Lys 
    1160                 1165                 1170             


Lys Asp  Lys Ala Gly Asn Leu  Ala Lys Glu Ala Leu  Asn Ile Arg 
    1175                 1180                 1185             


Thr Val  Ser Glu Gln Leu Lys  Ala Phe Asn Gln Asp  Lys Pro Glu 
    1190                 1195                 1200             


Lys Pro  Arg Thr Leu Leu Val  Pro Ile Ala Gly Gly  Pro Ile Phe 
    1205                 1210                 1215             


Val Pro  Ile Ser Glu Val Gly  Leu Ser Ser Phe Gly  Leu Lys Pro 
    1220                 1225                 1230             


Gln Val  Val Gln Ala Asp Ile  Asn Ala Ala Ile Asn  Leu Gly Leu 
    1235                 1240                 1245             


Arg Ala  Ile Ser Asp Pro Arg  Ile Trp Glu Ile His  Pro Arg Leu 
    1250                 1255                 1260             


Arg Thr  Glu Lys Arg Asp Gly  Arg Leu Phe Ala Arg  Glu Lys Arg 
    1265                 1270                 1275             


Lys Tyr  Gly Glu Glu Lys Val  Glu Val Gln Pro Ser  Lys Asn Glu 
    1280                 1285                 1290             


Lys Ala  Lys Lys Val Lys Asp  Asp Arg Lys Pro Asn  Tyr Phe Ala 
    1295                 1300                 1305             


Asp Phe  Ser Gly Lys Val Asp  Trp Gly Phe Gly Asn  Ile Lys Asn 
    1310                 1315                 1320             


Glu Ser  Gly Leu Thr Leu Val  Ser Gly Lys Ala Leu  Trp Trp Thr 
    1325                 1330                 1335             


Ile Asn  Gln Leu Gln Trp Glu  Arg Cys Phe Asp Ile  Asn Lys Arg 
    1340                 1345                 1350             


His Ile  Glu Asp Trp Ser Asn  Lys Gln Lys Gln 
    1355                 1360                 


<210> 621
<211> 1313
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 621
Met Gly Glu Glu Asn Asn Phe Ser Gln Phe Thr Gly Leu Tyr Glu Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Trp Glu Thr Glu Lys 
            20                  25                  30          


Leu Leu Ile Glu Asn Gln Val Phe Pro Lys Asp Lys Ile Val Tyr Glu 
        35                  40                  45              


Ser Tyr Lys Lys Ile Arg Pro Tyr Leu Asp Lys Leu His Leu Gln Phe 
    50                  55                  60                  


Ile Glu Glu Ser Leu Ser Ser Val Lys Leu Asp Phe Asn Glu Ile Glu 
65                  70                  75                  80  


Lys Lys Phe Leu Glu Trp Asp Lys Glu Lys Asp Lys Thr Thr Lys Asn 
                85                  90                  95      


Lys Leu Lys Glu Glu Ile Phe Trp Lys Asn Lys Lys Trp Trp Leu Asn 
            100                 105                 110         


Ser Asn Leu Arg Lys Asp Met Val Ser Tyr Phe Asn Leu Asn Trp Lys 
        115                 120                 125             


Lys Trp Ile Asn Asn Phe Glu Asn Lys Thr Ile Val Asn Glu Lys Trp 
    130                 135                 140                 


Lys Glu Glu Lys Ile Lys Ile Lys Trp Glu Trp Tyr Lys Ile Leu Leu 
145                 150                 155                 160 


Ser Asp Ser Asn Leu Asn Ile Leu Ser Asp Phe Phe Thr Gln Glu Lys 
                165                 170                 175     


Glu Trp Asp Asn Val Leu Ile Glu Lys Tyr Ile Glu Asn Pro Asn Phe 
            180                 185                 190         


Lys Glu Asn Asp Trp Glu Lys Lys Phe Ile Leu Glu Lys Gln Asn Leu 
        195                 200                 205             


Phe Lys Ser Phe Lys Trp Phe Thr Thr Tyr Phe Thr Asn Phe Asn His 
    210                 215                 220                 


Ser Arg Glu Asn Phe Tyr Lys Asp Asp Trp Lys Ser Trp Arg Ile Ala 
225                 230                 235                 240 


Thr Arg Ile Ile Asp Glu Asn Leu Ile Phe Phe Leu Lys Asn Lys Lys 
                245                 250                 255     


Ala Phe Asp Glu Lys Tyr Lys Asn Asn Ser Glu Ile Thr Val Lys Phe 
            260                 265                 270         


Asn Glu Lys Leu Leu Asn Phe Trp Glu Lys Leu Glu Asp Phe Phe Ser 
        275                 280                 285             


Leu Asp Phe Tyr Asn Arg Cys Tyr Thr Trp Lys Gln Ile Glu Tyr Tyr 
    290                 295                 300                 


Asn Gln Leu Ile Trp Glu Leu Asn Ser Val Val Asn His Glu Lys Gln 
305                 310                 315                 320 


Ala Lys Phe Ser Glu Tyr Thr Gln Asn Lys Lys Val Ser Glu Asn Asn 
                325                 330                 335     


Lys Phe Asn Lys Tyr Asp Phe Pro Ile Phe Lys Glu Leu Tyr Lys Gln 
            340                 345                 350         


Ile Leu Ser Glu Lys Ala Thr Glu Gln Lys Phe Ile Glu Ile Asn Asp 
        355                 360                 365             


Phe Lys Glu Leu Lys Gln Asn Leu Gln Glu Leu Ile Glu Lys Asn Lys 
    370                 375                 380                 


Gln Lys Asn Lys Phe Ala Ile Asn Leu Thr Lys Ser Leu Ile Glu Lys 
385                 390                 395                 400 


Ile Asp Glu Tyr Asp Phe Glu Lys Ile Tyr Ile Ser Lys Leu Ser Leu 
                405                 410                 415     


Asn Thr Ile Ser Ser Lys Phe Phe Trp Ser Asn Lys Trp Phe Phe Ile 
            420                 425                 430         


Gln Glu Asn Leu Glu Lys Asn Ile Trp Lys Lys Asn Lys Asn Trp Lys 
        435                 440                 445             


Ile Asp Leu Pro Asp Phe Ile Lys Leu Ser Asp Ile Lys Thr Ala Leu 
    450                 455                 460                 


Glu Asn Phe Asn Lys Ile Leu Phe Glu Asp Lys Glu Asn Lys Glu Asn 
465                 470                 475                 480 


Ile Phe Lys Glu Glu Phe Asp Asn Ile Thr Glu Asn Asn Ile Phe Ile 
                485                 490                 495     


Lys Phe Met Lys Ile Tyr Glu Asn Glu Phe Ile Asn Leu Ile Glu Trp 
            500                 505                 510         


Lys Lys Asn Asn Lys Trp Asp Tyr Glu Ile Ile Trp Tyr Asn Lys Ser 
        515                 520                 525             


Leu Leu Asp Leu Glu Lys Asn Ile Leu Asn Ile Ser Asp Phe Ser Asp 
    530                 535                 540                 


Lys Lys Glu Glu Lys Glu Lys Gln Ile Glu Tyr Ile Lys Lys Tyr Leu 
545                 550                 555                 560 


Asp Ser Ser Leu Asn Ile Tyr Arg Val Met Lys Tyr Phe Ala Leu Glu 
                565                 570                 575     


Lys Gly Lys Glu Ser Val Glu Trp Glu Phe Glu Thr Asp Asp Ile Phe 
            580                 585                 590         


Tyr Asn Glu Phe Lys Lys Phe Tyr Ile Asp Asn Glu Ile Ile Ser Tyr 
        595                 600                 605             


Tyr Asn Glu Phe Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser Ser Asn 
    610                 615                 620                 


Lys Leu Lys Leu Asn Phe Glu Asn Trp Thr Leu Ile Asp Gly Trp Asp 
625                 630                 635                 640 


Lys Asn Lys Glu Pro Asp Asn Tyr Trp Thr Ile Leu Arg Lys Asn Trp 
                645                 650                 655     


Lys Tyr Phe Leu Ala Leu Gln Ile Lys Trp Lys Asn Asn Ile Phe Tyr 
            660                 665                 670         


Lys Lys Lys Trp Ser Trp Val Ile Asp Ile Glu Glu Ala Tyr Lys Ile 
        675                 680                 685             


Asp Leu Trp Asp Glu Phe Tyr Glu Lys Met Asp Tyr Lys Phe Leu Pro 
    690                 695                 700                 


Asp Pro Lys Lys Met Leu Pro Lys Val Ile Phe Ala Lys Ser Asn Val 
705                 710                 715                 720 


Lys Leu Phe Asn Pro Ser Lys Glu Ile Leu Gln Ile Lys Glu Asn Glu 
                725                 730                 735     


Thr Phe Lys Thr Trp Asp Lys Phe Lys Val Asn Asp Phe Tyr Lys Ile 
            740                 745                 750         


Val Asp Phe Tyr Lys Glu Asn Ile Ile Lys Tyr Pro Asp Trp Lys Ile 
        755                 760                 765             


Phe Asn Phe Lys Phe Ser Asp Thr Lys Thr Tyr Asn Asn Leu Ser Asp 
    770                 775                 780                 


Phe Tyr Lys Glu Ile Glu Leu Trp Ser Tyr Asp Leu Asn Phe Arg Lys 
785                 790                 795                 800 


Val Ser Lys Lys Tyr Ile Leu Lys Ser Ile Glu Glu Lys Asn Ile Tyr 
                805                 810                 815     


Leu Phe Glu Ile Tyr Asn Lys Asp Phe Ala Asp Trp Lys Thr Trp Ser 
            820                 825                 830         


Glu Asn Leu His Thr Met Tyr Phe Lys Trp Leu Phe Glu Glu Asn Asn 
        835                 840                 845             


Leu Asn Asn Ile Val Leu Lys Leu Asn Trp Gln Ala Glu Ile Phe Arg 
    850                 855                 860                 


Arg Glu Ala Ser Leu Lys Glu Lys Glu Val Asn Arg Ala Lys Glu Asn 
865                 870                 875                 880 


Lys Glu Lys Ser His Asn Ile Ile Glu Asn Ala Arg Tyr Thr Lys Asp 
                885                 890                 895     


Lys Leu Phe Phe His Cys Pro Ile Lys Leu Asn Phe Ala Lys His Asn 
            900                 905                 910         


Glu Lys Ile Asn Gln Glu Ile Leu Lys Tyr Ile Ser Asp Asn Lys Glu 
        915                 920                 925             


Ile Asn Ile Ile Trp Ile Asp Arg Trp Glu Lys His Leu Ala Tyr Tyr 
    930                 935                 940                 


Ser Val Ile Asn Arg Asp Trp Asn Ile Ile Lys Asp Lys Asn Trp Asn 
945                 950                 955                 960 


Leu Val Lys Trp Ser Leu Asn Ile Val Trp Asn Asn Gln Asn Tyr His 
                965                 970                 975     


Asp Lys Leu Glu Thr Arg Glu Lys Glu Arg Gln Asp Ala Arg Trp Ser 
            980                 985                 990         


Trp Lys Thr Ile Trp Asn Ile Lys  Asp Leu Lys Gln Gly  Tyr Ile Ser 
        995                 1000                 1005             


Gln Val  Val His Lys Leu Ala  Glu Leu Val Ile Glu  His Asn Ala 
    1010                 1015                 1020             


Ile Ile  Val Phe Glu Asp Leu  Asn Ser Trp Phe Lys  Arg Trp Arg 
    1025                 1030                 1035             


Gln Lys  Ile Glu Arg Gln Val  Tyr Gln Lys Leu Glu  Lys Ala Leu 
    1040                 1045                 1050             


Ile Glu  Lys Leu Asn Tyr Leu  Thr Phe Lys Asp Lys  Asn Phe Trp 
    1055                 1060                 1065             


Glu Asn  Trp His Tyr Leu Lys  Ala Tyr Gln Leu Thr  Ala Pro Phe 
    1070                 1075                 1080             


Glu Thr  Phe Glu Lys Val Trp  Lys Gln Thr Trp Val  Ile Phe Tyr 
    1085                 1090                 1095             


Thr Asp  Pro Ser Tyr Thr Ser  Ser Thr Cys Pro Ala  Cys Trp Phe 
    1100                 1105                 1110             


Arg Lys  Asp Leu Tyr Leu Lys  Tyr Ser Asn Leu Lys  Asn Ala Leu 
    1115                 1120                 1125             


Trp Asp  Ile Glu Lys Ile Asp  Ser Ile Ile Phe Asp  Trp Lys Arg 
    1130                 1135                 1140             


Phe Ile  Phe Glu Tyr Asn Asn  Lys Lys Val Phe Thr  Asp Arg Asp 
    1145                 1150                 1155             


Arg Lys  Arg Asn Ile Ser Ser  Glu Glu Ser Trp Ile  Lys Trp Trp 
    1160                 1165                 1170             


Lys Thr  Ile Asp Asn Asn Ile  Thr Glu Phe Leu Glu  Ile Leu Phe 
    1175                 1180                 1185             


Lys Lys  Ser Asn Ile Asp Tyr  Thr Ser Trp Asn Asn  Leu Ile Leu 
    1190                 1195                 1200             


Asp Ile  Gln Glu Ile Asn Glu  Lys Glu Leu Tyr Lys  Trp Val Phe 
    1205                 1210                 1215             


Asp Asn  Phe Asn Ala Ile Leu  Asn Ile Arg Asn Ser  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asn  Ser Arg Thr Trp Asp  Phe Ile Cys Cys Pro  Ala Cys Asp 
    1235                 1240                 1245             


Phe Asp  Ser Arg Lys Glu Asn  Lys Ile Trp Ile Glu  Asn Trp Asp 
    1250                 1255                 1260             


Asp Asn  Trp Ala Phe Asn Ile  Ala Arg Lys Trp Ile  Ile Ile Leu 
    1265                 1270                 1275             


Asn Lys  Ile Asp Ser Tyr Leu  Asn Glu Lys Trp Ser  Leu Asp Lys 
    1280                 1285                 1290             


Ile Leu  Trp Trp Asp Met Ile  Val Lys Gln Ile Asp  Trp Asp Asp 
    1295                 1300                 1305             


Phe Thr  His Lys Lys 
    1310             


<210> 622
<211> 767
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 622
Met Ala Gln Ala Ser Ser Thr Pro Ala Val Ser Pro Arg Pro Arg Pro 
1               5                   10                  15      


Arg Tyr Arg Glu Glu Arg Thr Leu Val Arg Lys Leu Leu Pro Arg Pro 
            20                  25                  30          


Gly Gln Ser Lys Gln Glu Phe Arg Glu Asn Val Lys Lys Leu Arg Lys 
        35                  40                  45              


Ala Phe Leu Gln Phe Asn Ala Asp Val Ser Gly Val Cys Gln Trp Ala 
    50                  55                  60                  


Ile Gln Phe Arg Pro Arg Tyr Gly Lys Pro Ala Glu Pro Thr Glu Thr 
65                  70                  75                  80  


Phe Trp Lys Phe Phe Leu Glu Pro Glu Thr Ser Leu Pro Pro Asn Asp 
                85                  90                  95      


Ser Arg Ser Pro Glu Phe Arg Arg Leu Gln Ala Phe Glu Ala Ala Ala 
            100                 105                 110         


Gly Ile Asn Gly Ala Ala Ala Leu Asp Asp Pro Ala Phe Thr Asn Glu 
        115                 120                 125             


Leu Arg Asp Ser Ile Leu Ala Val Ala Ser Arg Pro Lys Thr Lys Glu 
    130                 135                 140                 


Ala Gln Arg Leu Phe Ser Arg Leu Lys Asp Tyr Gln Pro Ala His Arg 
145                 150                 155                 160 


Met Ile Leu Ala Lys Val Ala Ala Glu Trp Ile Glu Ser Arg Tyr Arg 
                165                 170                 175     


Arg Ala His Gln Asn Trp Glu Arg Asn Tyr Glu Glu Trp Lys Lys Glu 
            180                 185                 190         


Lys Gln Glu Trp Glu Gln Asn His Pro Glu Leu Thr Pro Glu Ile Arg 
        195                 200                 205             


Glu Ala Phe Asn Gln Ile Phe Gln Gln Leu Glu Val Lys Glu Lys Arg 
    210                 215                 220                 


Val Arg Ile Cys Pro Ala Ala Arg Leu Leu Gln Asn Lys Asp Asn Cys 
225                 230                 235                 240 


Gln Tyr Ala Gly Lys Asn Lys His Ser Val Leu Cys Asn Gln Phe Asn 
                245                 250                 255     


Glu Phe Lys Lys Asn His Leu Gln Gly Lys Ala Ile Lys Phe Phe Tyr 
            260                 265                 270         


Lys Asp Ala Glu Lys Tyr Leu Arg Cys Gly Leu Gln Ser Leu Lys Pro 
        275                 280                 285             


Asn Val Gln Gly Pro Phe Arg Glu Asp Trp Asn Lys Tyr Leu Arg Tyr 
    290                 295                 300                 


Met Asn Leu Lys Glu Glu Thr Leu Arg Gly Lys Asn Gly Gly Arg Leu 
305                 310                 315                 320 


Pro His Cys Lys Asn Leu Gly Gln Glu Cys Glu Phe Asn Pro His Thr 
                325                 330                 335     


Ala Leu Cys Lys Gln Tyr Gln Gln Gln Leu Ser Ser Arg Pro Asp Leu 
            340                 345                 350         


Val Gln His Asp Glu Leu Tyr Arg Lys Trp Arg Arg Glu Tyr Trp Arg 
        355                 360                 365             


Glu Pro Arg Lys Pro Val Phe Arg Tyr Pro Ser Val Lys Arg His Ser 
    370                 375                 380                 


Ile Ala Lys Ile Phe Gly Glu Asn Tyr Phe Gln Ala Asp Phe Lys Asn 
385                 390                 395                 400 


Ser Val Val Gly Leu Arg Leu Asp Ser Met Pro Ala Gly Gln Tyr Leu 
                405                 410                 415     


Glu Phe Ala Phe Ala Pro Trp Pro Arg Asn Tyr Arg Pro Gln Pro Gly 
            420                 425                 430         


Glu Thr Glu Ile Ser Ser Val His Leu His Phe Val Gly Thr Arg Pro 
        435                 440                 445             


Arg Ile Gly Phe Arg Phe Arg Val Pro His Lys Arg Ser Arg Phe Asp 
    450                 455                 460                 


Cys Thr Gln Glu Glu Leu Asp Glu Leu Arg Ser Arg Thr Phe Pro Arg 
465                 470                 475                 480 


Lys Ala Gln Asp Gln Lys Phe Leu Glu Ala Ala Arg Lys Arg Leu Leu 
                485                 490                 495     


Glu Thr Phe Pro Gly Asn Ala Glu Gln Glu Leu Arg Leu Leu Ala Val 
            500                 505                 510         


Asp Leu Gly Thr Asp Ser Ala Arg Ala Ala Phe Phe Ile Gly Lys Thr 
        515                 520                 525             


Phe Gln Gln Ala Phe Pro Leu Lys Ile Val Lys Ile Glu Lys Leu Tyr 
    530                 535                 540                 


Glu Gln Trp Pro Asn Gln Lys Gln Ala Gly Asp Arg Arg Asp Ala Ser 
545                 550                 555                 560 


Ser Lys Gln Pro Arg Pro Gly Leu Ser Arg Asp His Val Gly Arg His 
                565                 570                 575     


Leu Gln Lys Met Arg Ala Gln Ala Ser Glu Ile Ala Gln Lys Arg Gln 
            580                 585                 590         


Glu Leu Thr Gly Thr Pro Ala Pro Glu Thr Thr Thr Asp Gln Ala Ala 
        595                 600                 605             


Lys Lys Ala Thr Leu Gln Pro Phe Asp Leu Arg Gly Leu Thr Val His 
    610                 615                 620                 


Thr Ala Arg Met Ile Arg Asp Trp Ala Arg Leu Asn Ala Arg Gln Ile 
625                 630                 635                 640 


Ile Gln Leu Ala Glu Glu Asn Gln Val Asp Leu Ile Val Leu Glu Ser 
                645                 650                 655     


Leu Arg Gly Phe Arg Pro Pro Gly Tyr Glu Asn Leu Asp Gln Glu Lys 
            660                 665                 670         


Lys Arg Arg Val Ala Phe Phe Ala His Gly Arg Ile Arg Arg Lys Val 
        675                 680                 685             


Thr Glu Lys Ala Val Glu Arg Gly Met Arg Val Val Thr Val Pro Tyr 
    690                 695                 700                 


Leu Ala Ser Ser Lys Val Cys Ala Glu Cys Arg Lys Lys Gln Lys Asp 
705                 710                 715                 720 


Asn Lys Gln Trp Glu Lys Asn Lys Lys Arg Gly Leu Phe Lys Cys Glu 
                725                 730                 735     


Gly Cys Gly Ser Gln Ala Gln Val Asp Glu Asn Ala Ala Arg Val Leu 
            740                 745                 750         


Gly Arg Val Phe Trp Gly Glu Ile Glu Leu Pro Thr Ala Ile Pro 
        755                 760                 765         


<210> 623
<211> 1313
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 623
Met Gly Glu Glu Asn Asn Phe Ser Gln Phe Thr Gly Leu Tyr Glu Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Trp Glu Thr Glu Lys 
            20                  25                  30          


Leu Leu Ile Glu Asn Gln Val Phe Pro Lys Asp Lys Ile Val Tyr Glu 
        35                  40                  45              


Ser Tyr Lys Lys Ile Arg Pro Tyr Leu Asp Lys Leu His Leu Gln Phe 
    50                  55                  60                  


Ile Glu Glu Ser Leu Ser Ser Val Lys Leu Asp Phe Asn Glu Ile Glu 
65                  70                  75                  80  


Lys Lys Phe Leu Glu Trp Asp Lys Glu Lys Asp Lys Thr Thr Lys Asn 
                85                  90                  95      


Lys Leu Lys Glu Glu Ile Phe Trp Lys Asn Lys Lys Trp Trp Leu Asn 
            100                 105                 110         


Ser Asn Leu Arg Lys Asp Met Val Ser Tyr Phe Asn Leu Asn Trp Lys 
        115                 120                 125             


Lys Trp Ile Asn Asn Phe Glu Asn Lys Thr Ile Val Asn Glu Lys Trp 
    130                 135                 140                 


Lys Glu Glu Lys Ile Lys Ile Lys Trp Glu Trp Tyr Lys Ile Leu Leu 
145                 150                 155                 160 


Ser Asp Ser Asn Leu Asn Ile Leu Ser Asp Phe Phe Thr Gln Glu Lys 
                165                 170                 175     


Glu Trp Asp Asn Val Leu Ile Glu Lys Tyr Ile Glu Asn Pro Asn Phe 
            180                 185                 190         


Lys Glu Asn Asp Trp Glu Lys Lys Phe Ile Leu Glu Lys Gln Asn Leu 
        195                 200                 205             


Phe Lys Ser Phe Lys Trp Phe Thr Thr Tyr Phe Thr Asn Phe Asn His 
    210                 215                 220                 


Ser Arg Glu Asn Phe Tyr Lys Asp Asp Trp Lys Ser Trp Arg Ile Ala 
225                 230                 235                 240 


Thr Arg Ile Ile Asp Glu Asn Leu Ile Phe Phe Leu Lys Asn Lys Lys 
                245                 250                 255     


Ala Phe Asp Glu Lys Tyr Lys Asn Asn Ser Glu Ile Thr Val Lys Phe 
            260                 265                 270         


Asn Glu Lys Leu Leu Asn Phe Trp Glu Lys Leu Glu Asp Phe Phe Ser 
        275                 280                 285             


Leu Asp Phe Tyr Asn Arg Cys Tyr Thr Trp Lys Gln Ile Glu Tyr Tyr 
    290                 295                 300                 


Asn Gln Leu Ile Trp Glu Leu Asn Ser Val Val Asn His Glu Lys Gln 
305                 310                 315                 320 


Ala Lys Phe Ser Glu Tyr Thr Gln Asn Lys Lys Val Ser Glu Asn Asn 
                325                 330                 335     


Lys Phe Asn Lys Tyr Asp Phe Pro Ile Phe Lys Glu Leu Tyr Lys Gln 
            340                 345                 350         


Ile Leu Ser Glu Lys Ala Thr Glu Gln Lys Phe Ile Glu Ile Asn Asp 
        355                 360                 365             


Phe Lys Glu Leu Lys Gln Asn Leu Gln Glu Leu Ile Glu Lys Asn Lys 
    370                 375                 380                 


Gln Lys Asn Lys Phe Ala Ile Asn Leu Thr Lys Ser Leu Ile Glu Lys 
385                 390                 395                 400 


Ile Asp Glu Tyr Asp Phe Glu Lys Ile Tyr Ile Ser Lys Leu Ser Leu 
                405                 410                 415     


Asn Thr Ile Ser Ser Lys Phe Phe Trp Ser Asn Lys Trp Phe Phe Ile 
            420                 425                 430         


Gln Glu Asn Leu Glu Lys Asn Ile Trp Lys Lys Asn Lys Asn Trp Lys 
        435                 440                 445             


Ile Asp Leu Pro Asp Phe Ile Lys Leu Ser Asp Ile Lys Thr Ala Leu 
    450                 455                 460                 


Glu Asn Phe Asn Lys Ile Leu Phe Glu Asp Lys Glu Asn Lys Glu Asn 
465                 470                 475                 480 


Ile Phe Lys Glu Glu Phe Asp Asn Ile Thr Glu Asn Asn Ile Phe Ile 
                485                 490                 495     


Lys Phe Met Lys Ile Tyr Glu Asn Glu Phe Ile Asn Leu Ile Glu Trp 
            500                 505                 510         


Lys Lys Asn Asn Lys Trp Asp Tyr Glu Ile Ile Trp Tyr Asn Lys Ser 
        515                 520                 525             


Leu Leu Asp Leu Glu Lys Asn Ile Leu Asn Ile Ser Asp Phe Ser Asp 
    530                 535                 540                 


Lys Lys Glu Glu Lys Glu Lys Gln Ile Glu Tyr Ile Lys Lys Tyr Leu 
545                 550                 555                 560 


Asp Ser Ser Leu Asn Ile Tyr Arg Val Met Lys Tyr Phe Ala Leu Glu 
                565                 570                 575     


Lys Gly Lys Glu Ser Val Glu Trp Glu Phe Glu Thr Asp Asp Ile Phe 
            580                 585                 590         


Tyr Asn Glu Phe Lys Lys Phe Tyr Ile Asp Asn Glu Ile Ile Ser Tyr 
        595                 600                 605             


Tyr Asn Glu Phe Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser Ser Asn 
    610                 615                 620                 


Lys Leu Lys Leu Asn Phe Glu Asn Trp Thr Leu Ile Asp Gly Trp Asp 
625                 630                 635                 640 


Lys Asn Lys Glu Pro Asp Asn Tyr Trp Thr Ile Leu Arg Lys Asn Trp 
                645                 650                 655     


Lys Tyr Phe Leu Ala Leu Gln Ile Lys Trp Lys Asn Asn Ile Phe Tyr 
            660                 665                 670         


Lys Lys Lys Trp Ser Trp Val Ile Asp Ile Glu Glu Ala Tyr Lys Ile 
        675                 680                 685             


Asp Leu Trp Asp Glu Phe Tyr Glu Lys Met Asp Tyr Lys Phe Leu Pro 
    690                 695                 700                 


Asp Pro Lys Lys Met Leu Pro Lys Val Ile Phe Ala Lys Ser Asn Val 
705                 710                 715                 720 


Lys Leu Phe Asn Pro Ser Lys Glu Ile Leu Gln Ile Lys Glu Asn Glu 
                725                 730                 735     


Thr Phe Lys Thr Trp Asp Lys Phe Lys Val Asn Asp Phe Tyr Lys Ile 
            740                 745                 750         


Val Asp Phe Tyr Lys Glu Asn Ile Ile Lys Tyr Pro Asp Trp Lys Ile 
        755                 760                 765             


Phe Asn Phe Lys Phe Ser Asp Thr Lys Thr Tyr Asn Asn Leu Ser Asp 
    770                 775                 780                 


Phe Tyr Lys Glu Ile Glu Leu Trp Ser Tyr Asp Leu Asn Phe Arg Lys 
785                 790                 795                 800 


Val Ser Lys Lys Tyr Ile Leu Lys Ser Ile Glu Glu Lys Asn Ile Tyr 
                805                 810                 815     


Leu Phe Glu Ile Tyr Asn Lys Asp Phe Ala Asp Trp Lys Thr Trp Ser 
            820                 825                 830         


Glu Asn Leu His Thr Met Tyr Phe Lys Trp Leu Phe Glu Glu Asn Asn 
        835                 840                 845             


Leu Asn Asn Ile Val Leu Lys Leu Asn Trp Gln Ala Glu Ile Phe Arg 
    850                 855                 860                 


Arg Glu Ala Ser Leu Lys Glu Lys Glu Val Asn Arg Ala Lys Glu Asn 
865                 870                 875                 880 


Lys Glu Lys Ser His Asn Ile Ile Glu Asn Ala Arg Tyr Thr Lys Asp 
                885                 890                 895     


Lys Leu Phe Phe His Cys Pro Ile Lys Leu Asn Phe Ala Lys His Asn 
            900                 905                 910         


Glu Lys Ile Asn Gln Glu Ile Leu Lys Tyr Ile Ser Asp Asn Lys Glu 
        915                 920                 925             


Ile Asn Ile Ile Trp Ile Asp Arg Trp Glu Lys His Leu Ala Tyr Tyr 
    930                 935                 940                 


Ser Val Ile Asn Arg Asp Trp Asn Ile Ile Lys Asp Lys Asn Trp Asn 
945                 950                 955                 960 


Leu Val Lys Trp Ser Leu Asn Ile Val Trp Asn Asn Gln Asn Tyr His 
                965                 970                 975     


Asp Lys Leu Glu Thr Arg Glu Lys Glu Arg Gln Asp Ala Arg Trp Ser 
            980                 985                 990         


Trp Lys Thr Ile Trp Asn Ile Lys  Asp Leu Lys Gln Gly  Tyr Ile Ser 
        995                 1000                 1005             


Gln Val  Val His Lys Leu Ala  Glu Leu Val Ile Glu  His Asn Ala 
    1010                 1015                 1020             


Ile Ile  Val Phe Glu Asp Leu  Asn Ser Trp Phe Lys  Arg Trp Arg 
    1025                 1030                 1035             


Gln Lys  Ile Glu Arg Gln Val  Tyr Gln Lys Leu Glu  Lys Ala Leu 
    1040                 1045                 1050             


Ile Glu  Lys Leu Asn Tyr Leu  Thr Phe Lys Asp Lys  Asn Phe Trp 
    1055                 1060                 1065             


Glu Asn  Trp His Tyr Leu Lys  Ala Tyr Gln Leu Thr  Ala Pro Phe 
    1070                 1075                 1080             


Glu Thr  Phe Glu Lys Val Trp  Lys Gln Thr Trp Val  Ile Phe Tyr 
    1085                 1090                 1095             


Thr Asp  Pro Ser Tyr Thr Ser  Ser Thr Cys Pro Ala  Cys Trp Phe 
    1100                 1105                 1110             


Arg Lys  Asp Leu Tyr Leu Lys  Tyr Ser Asn Leu Lys  Asn Ala Leu 
    1115                 1120                 1125             


Trp Asp  Ile Glu Lys Ile Asp  Ser Ile Ile Phe Asp  Trp Lys Arg 
    1130                 1135                 1140             


Phe Ile  Phe Glu Tyr Asn Asn  Lys Lys Val Phe Thr  Asp Arg Asp 
    1145                 1150                 1155             


Arg Lys  Arg Asn Ile Ser Ser  Glu Glu Ser Trp Ile  Lys Trp Trp 
    1160                 1165                 1170             


Lys Thr  Ile Asp Asn Asn Ile  Thr Glu Phe Leu Glu  Ile Leu Phe 
    1175                 1180                 1185             


Lys Lys  Ser Asn Ile Asp Tyr  Thr Ser Trp Asn Asn  Leu Ile Leu 
    1190                 1195                 1200             


Asp Ile  Gln Glu Ile Asn Glu  Lys Glu Leu Tyr Lys  Trp Val Phe 
    1205                 1210                 1215             


Asp Asn  Phe Asn Ala Ile Leu  Asn Ile Arg Asn Ser  Thr Ile Lys 
    1220                 1225                 1230             


Asp Asn  Ser Arg Thr Trp Asp  Phe Ile Cys Cys Pro  Ala Cys Asp 
    1235                 1240                 1245             


Phe Asp  Ser Arg Lys Glu Asn  Lys Ile Trp Ile Glu  Asn Trp Asp 
    1250                 1255                 1260             


Asp Asn  Trp Ala Phe Asn Ile  Ala Arg Lys Trp Ile  Ile Ile Leu 
    1265                 1270                 1275             


Asn Lys  Ile Asp Ser Tyr Leu  Asn Glu Lys Trp Ser  Leu Asp Lys 
    1280                 1285                 1290             


Ile Leu  Trp Trp Asp Met Ile  Val Lys Gln Ile Asp  Trp Asp Asp 
    1295                 1300                 1305             


Phe Thr  His Lys Lys 
    1310             


<210> 624
<211> 1500
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 624
Met Ala Thr Ala Ile Asn Tyr Pro Thr Thr Gln Arg Ala Tyr Thr Leu 
1               5                   10                  15      


Arg Leu Arg Gly Ile Asp Pro Gln Asp Gln Ser Trp Arg Asp Ala Leu 
            20                  25                  30          


Trp Ala Thr His Glu Ala Val Asn Arg Gly Ala Lys Val Phe Gly Glu 
        35                  40                  45              


Trp Leu Leu Thr Leu Arg Gly Gly Leu Asp His Gln Leu Ala Asp Ala 
    50                  55                  60                  


Pro Val Lys Val Arg Gly Gly Thr Thr Arg Leu Pro Ser Asp Glu Glu 
65                  70                  75                  80  


Arg Arg Asp Arg Arg Val Leu Leu Ala Leu Ser Trp Leu Ser Val Glu 
                85                  90                  95      


Asp Ala His Gly Ala Pro Pro Asp Ala Ser Leu Ile Val Ala Lys Gly 
            100                 105                 110         


Thr Asp Ser Ala Asp Cys Arg Ala Arg Lys Leu Ala Asp Ala Leu Ile 
        115                 120                 125             


Ala Ile Leu Gln Ala Arg Ser Val Ala Ala Ser Glu Ile Gly Asp Pro 
    130                 135                 140                 


Ser Lys Pro Pro Glu Asp Gln Pro Gly Thr Trp Leu Gly Asp Cys Met 
145                 150                 155                 160 


Gly Ser Leu Ser Ala Ala Ile Arg Asp Asp Ala Val Trp Val Asn Arg 
                165                 170                 175     


Ser Lys Ala Phe Asp Ala Ala Thr Gln Ser Cys Pro Ser Leu Thr Arg 
            180                 185                 190         


Asp Glu Ile Trp Asp Phe Leu Glu Pro Phe Phe Ala Ser Pro Asp Ala 
        195                 200                 205             


Tyr Leu Lys Pro Glu Arg Ala Glu Ser Asp Glu Gly Asp Ser Thr Ser 
    210                 215                 220                 


Ala Ala Thr Glu Asp Lys Ala Lys Asp Leu Val Gln Lys Ala Gly Gly 
225                 230                 235                 240 


Trp Leu Ser Lys Arg Met Gly Ala Gly Gly Gly Ala Asn Phe Gln Asp 
                245                 250                 255     


Leu Ala Arg Ala Tyr Gln Ala Ile Ala Gln Trp Ala Ser Ser Ala Gln 
            260                 265                 270         


Pro Gly Gln Ser Ala Gln Gln Ala Val Gly Ser Leu Ala Gly Tyr Leu 
        275                 280                 285             


Ser Gln His Gly Phe Ser Pro Thr Ala Asn Asp Ala Thr Gly Val Leu 
    290                 295                 300                 


Ala Val Ile Ser Gly Pro Gly Tyr Lys Ser Ala Thr Arg Asn His Ile 
305                 310                 315                 320 


Thr Ala Ile Ala Thr Ser Pro Glu Ile Thr Pro Gln Asp Leu Ser Lys 
                325                 330                 335     


Leu Gln Glu Leu Ala Thr Lys Asp Lys Ala Gly Cys Ser Ser Lys Ile 
            340                 345                 350         


Gly Gly Lys Gly Pro Arg Pro Tyr Ala Thr Met Ile Leu Gln Gln Val 
        355                 360                 365             


Glu Ala Ala Cys Gly Phe Thr Tyr Leu Gln Ser Asp Gly Pro Ala Arg 
    370                 375                 380                 


His Arg Glu Phe Ser Val Met Leu Asp His Ala Ala Arg Arg Val Asn 
385                 390                 395                 400 


Val Ala His Ser Trp Ile Lys Asn Ala Glu Ala Glu Arg Arg Gln Phe 
                405                 410                 415     


Glu Ser Asp Ala Arg Arg Ile Lys Lys Val Pro Gln Asp Ala Leu Asn 
            420                 425                 430         


Trp Leu Arg Gly Tyr Cys Glu Glu Arg Gly Gly Ala Ser Gly Ser Leu 
        435                 440                 445             


Glu Gly Tyr Arg Ile Arg Arg Arg Ala Ile Asp Gly Trp Asp Gln Val 
    450                 455                 460                 


Val Ile Arg Trp Ser Arg Ser Asp Cys Gln Ser Ala Asp Asp Arg Ile 
465                 470                 475                 480 


Ala Ala Ala Arg Gln Leu Gln Asp Asp Pro Glu Ile Asp Lys Phe Gly 
                485                 490                 495     


Asp Ile Gln Leu Phe Glu Ala Leu Ala Ala Glu Glu Ala Leu Cys Val 
            500                 505                 510         


Trp Lys Pro Asp Gly Asn Pro Thr Ala Gln Pro Leu Lys Asp Phe Val 
        515                 520                 525             


Ala Ala Thr Glu Ala Asp Ala Lys Lys Lys Arg Phe Lys Val Pro Ala 
    530                 535                 540                 


Tyr Arg His Pro Asp Pro Leu Arg His Pro Val Phe Thr Asp Phe Gly 
545                 550                 555                 560 


Asn Ser Arg Trp Gly Ile Glu Tyr Ser Ala His Arg Ala Pro Ala Lys 
                565                 570                 575     


Cys Asp Glu Leu Gly Gln Gln Val Asp Arg Leu Thr Gln Ala Val Ala 
            580                 585                 590         


Glu Ala Gln Arg Asn Leu Asp Gly Ala Thr Ala Ala Gln Arg Ala Ser 
        595                 600                 605             


Arg Glu Ser Lys Leu Ala Glu Ala Gln Ser Lys Leu Val Ala Ala Gln 
    610                 615                 620                 


Thr Glu Phe Ala Ala Ile Asn Asp Pro His Arg Val Glu Leu Lys Leu 
625                 630                 635                 640 


Trp Asn Gly Gln Ala Val Ala Ala Ile Pro Met Arg Trp Ser Ser Lys 
                645                 650                 655     


Arg Leu Ile Ala Asp Leu Ser Leu Arg Arg Ala Thr Gln Pro Ser Ser 
            660                 665                 670         


Asp Gln Arg Ile Gly Val Thr Arg Ala Asp Arg Leu Gly Arg Ala Ala 
        675                 680                 685             


Gly Asn Ala Asp Asp Gly Arg Pro Val Thr Ile Thr Gly Leu Phe Gln 
    690                 695                 700                 


Gln Asp His Trp Asn Gly Arg Leu Gln Ala Pro Arg Ala Gln Leu Asp 
705                 710                 715                 720 


Ala Ile Ala Lys His Val Asp Lys His Gly Trp Asp Ala Lys Ala Arg 
                725                 730                 735     


Arg Gln Ile Ala Arg Ile Arg Trp Val Val Ser Phe Ser Ala Glu Leu 
            740                 745                 750         


Ser Gln Gln Gly Pro Trp Phe Glu Phe Cys His Arg Phe Gly Glu Asp 
        755                 760                 765             


Ala Pro Ala Arg Pro Phe Val Ser Arg His Gly Glu Tyr Ala Val Lys 
    770                 775                 780                 


His Arg Asp Asn Asp Gln Arg Lys Gly His Ala Lys Leu Ile Leu Ser 
785                 790                 795                 800 


Arg Leu Pro Gly Leu Arg Val Leu Ala Val Asp Leu Gly His Arg Tyr 
                805                 810                 815     


Ala Ala Ala Cys Ala Val Trp Glu Ala Ile Ser Ser Asp Gln Met Arg 
            820                 825                 830         


Gln Ala Cys Ala Ala Ala Asn Ala Pro Ala Pro His Pro Leu Ala Met 
        835                 840                 845             


Tyr Ile His Leu Lys Ser Thr Thr Ala Lys Gly Lys Pro Thr Thr Thr 
    850                 855                 860                 


Ile Tyr Arg Arg Ile Gly Pro Asp Lys Leu Pro Asp Gly Thr Pro His 
865                 870                 875                 880 


Pro Ala Pro Trp Ala Arg Leu Asp Arg Gln Phe Leu Ile Lys Leu Pro 
                885                 890                 895     


Gly Glu Asp Arg Pro Ala Arg Ala Ala Ser Pro Asp Glu Ile Lys Ala 
            900                 905                 910         


Val Glu Asp Phe Glu Asp Ser Val Gly Arg Val Arg Thr Ala Val Asp 
        915                 920                 925             


Pro Pro Arg Lys Arg Gly Val Asp Leu Leu Met His Asp Ala Val Arg 
    930                 935                 940                 


Thr Ala Arg Leu Ala Leu Ala Arg His Gly Arg Arg Ala Arg Ile Ala 
945                 950                 955                 960 


Phe Gln Leu Ile Ser Gln Val Arg Ile Leu Pro Gly Gly Arg Pro Gln 
                965                 970                 975     


Thr Leu Asp Asp Ala Gly Arg Arg Asp Leu Leu Asn Asp Thr Leu Ala 
            980                 985                 990         


Asp Trp Tyr Ala Leu Ala Thr Asp  Ser Arg Trp Thr Asp  Ala Ala Ala 
        995                 1000                 1005             


Arg Gln  Leu Trp Asn Glu Arg  Leu Ala Ala Leu Asn  Gly Gly Phe 
    1010                 1015                 1020             


Thr Ile  Asp Pro Pro Ala Asp  Ala Ser Gln Pro Glu  Ala Glu Arg 
    1025                 1030                 1035             


Thr Arg  Ala Gln Arg Arg Gln  Ala Glu Gln Glu Leu  Arg His Arg 
    1040                 1045                 1050             


Leu Ala  Ser Leu Val Glu Ala  Leu Phe Cys Asn Pro  Thr Leu Cys 
    1055                 1060                 1065             


Gln Gln  Leu His Gln Ala Trp  Thr Asp Arg Trp Asn  Ala Asp Asp 
    1070                 1075                 1080             


Gln Gln  Trp Arg Ser Arg Leu  Lys Trp Leu Ser Arg  Trp Leu Leu 
    1085                 1090                 1095             


Pro Arg  Gly Gly Ser Arg Arg  Asp Gly Ser Arg Arg  His Val Gly 
    1100                 1105                 1110             


Gly Leu  Ser Leu Thr Arg Ile  Ser Thr Leu Ile Asp  Phe Arg Arg 
    1115                 1120                 1125             


Lys Val  Gln Val Gly Tyr Phe  Thr Arg Leu Arg Pro  Asp Gly Ser 
    1130                 1135                 1140             


Arg Ala  Glu Ile Gly Pro Gln  Phe Gly Gln Ser Thr  Leu Asp Ala 
    1145                 1150                 1155             


Ile Gln  Arg Leu Lys Asp Gln  Arg Ile Lys Gln Leu  Thr Ser Arg 
    1160                 1165                 1170             


Ile Val  Glu Ala Ala Leu Gly  Ile Gly Val Glu Gln  Asp Arg Ile 
    1175                 1180                 1185             


Trp Asp  Ala Ala Lys Arg Lys  Trp Arg Thr Val Lys  Arg Pro Arg 
    1190                 1195                 1200             


Glu Pro  Arg Tyr His Val Asp  Asp Gln Gly Val Gln  Gln Arg Asp 
    1205                 1210                 1215             


Pro Arg  Phe Gln Ala Cys His  Ala Val Val Ile Glu  Asp Leu Ser 
    1220                 1225                 1230             


His Tyr  Arg Pro Glu Glu Thr  Arg Thr Arg Arg Glu  Asn Arg Ala 
    1235                 1240                 1245             


Thr Met  Asp Trp Lys Ser Ala  Glu Thr Arg Lys Arg  Leu Ala Asp 
    1250                 1255                 1260             


His Cys  Gln Leu Tyr Gly Leu  His Leu Arg Asp Val  Asn Pro Gln 
    1265                 1270                 1275             


Tyr Thr  Ser Arg Gln Asp Ser  Arg Thr Gly Ala Pro  Gly Cys Arg 
    1280                 1285                 1290             


Cys Val  Asp Val Ser Val Ala  Asp Phe Leu Thr Lys  Pro Ala Trp 
    1295                 1300                 1305             


Arg Lys  Gln Val Ala Gln Ala  Arg Gly Lys Val Ala  Ser Asn Arg 
    1310                 1315                 1320             


Gly Asp  Ala Arg Asp Arg Leu  Leu Val Glu Leu Asp  His Gln Leu 
    1325                 1330                 1335             


Thr Thr  Ala Asn Ser Leu Arg  Gly Glu Met Asp Ser  Leu Arg Ile 
    1340                 1345                 1350             


Pro Val  Asn Gly Gly Glu Val  Phe Val Ser Ala Asp  Pro Arg Ser 
    1355                 1360                 1365             


Pro Leu  Ala Ala Gly Ile Gln  Ala Asp Leu Asn Ala  Ala Ala Asn 
    1370                 1375                 1380             


Ile Gly  Leu Arg Ala Leu Met  Asp Pro Asp Phe Leu  Gly Thr Trp 
    1385                 1390                 1395             


Trp Tyr  Val Pro Cys Asp Pro  Ser Thr Lys Lys Pro  His Ile Glu 
    1400                 1405                 1410             


Lys Val  Lys Gly Ser Ile Leu  Ala Thr Val Gly Ala  Leu Gln Ala 
    1415                 1420                 1425             


Thr Ser  Glu Glu Ala Ala Ala  Pro Pro Arg Arg Gly  Arg Gly Gly 
    1430                 1435                 1440             


Thr Arg  Ser Ala Ala Pro Arg  Glu Val Ile Asn Leu  Trp Arg Asp 
    1445                 1450                 1455             


Pro Ser  Ala Val Arg Ile Gln  Asp Ala Thr Ala Gly  Glu Val Trp 
    1460                 1465                 1470             


Asp Val  Thr Pro Val Tyr Trp  Ser Ile Val Lys Asp  Arg Val Val 
    1475                 1480                 1485             


Asp Val  Leu Arg Gln Arg Asn  Thr Lys Ser Gly Asp  
    1490                 1495                 1500 


<210> 625
<211> 1202
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 625
Met Ala Val Arg Ser Val Lys Leu Lys Leu Leu Val Pro Arg Asp Gly 
1               5                   10                  15      


Ser Ala Glu Ser Val Arg Lys Arg Lys Ala Leu Trp Ala Thr His Gln 
            20                  25                  30          


Phe Val Asn Asp Ala Ala Ala Ala Tyr Ala Glu Leu Leu Leu Glu Met 
        35                  40                  45              


Arg Gln Glu Asp Val Cys Arg Gly Thr Asp Asp His Gly Lys Asp Val 
    50                  55                  60                  


Ile Glu Pro Ala Ala His Trp Gln Ala Lys Leu Arg Ala Arg Leu Ala 
65                  70                  75                  80  


Ala Lys Gln Leu Pro Pro Val Ala Val Ala Glu Ala Leu Pro Leu Leu 
                85                  90                  95      


Lys Ala Phe Tyr Gly Ser Arg Leu Ile Lys Ser Phe Val Ala Asn Asp 
            100                 105                 110         


Lys Gly Val Ala Gly Thr Gly Asn Ala Thr Asp Leu Asn Thr Trp Leu 
        115                 120                 125             


Ser Gly Leu Val Asp Pro Ala Ser Val Ala Gly Glu Lys Thr Glu Leu 
    130                 135                 140                 


Arg Lys Gln Leu Leu Ala Glu Leu Pro Leu Cys Glu Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Phe Glu Gly Ala Ala Arg Lys Met Leu Ala Lys Ser Asp Ala Arg 
                165                 170                 175     


Glu Ala Leu Leu Glu Gly Pro Gly Thr Gly Val Gly Trp Pro Ala Ala 
            180                 185                 190         


Tyr Asn Ala Asn Pro Thr Asp Ser Val Trp Leu Asp Met Leu His Lys 
        195                 200                 205             


Ala Ala Ala Lys Ala Arg Leu Glu Leu Ala Asp Thr Thr Val Ser Glu 
    210                 215                 220                 


Leu Lys Lys Leu Gly Val Phe Pro Leu Leu Gln Ala Ala Ser Ser Asn 
225                 230                 235                 240 


Arg Val Phe Gly Ser Gly Val Leu Asn Pro Phe Glu Arg Met Ala Ala 
                245                 250                 255     


Ala Gln Ala Ala Ala Ala Leu Leu Pro Trp Glu Thr Lys Arg His Glu 
            260                 265                 270         


Met Arg Lys Arg Arg Asp Lys Phe Ala Asp Gln Leu Asn Gln Trp Asp 
        275                 280                 285             


Thr Glu Phe Gly Ala Ser His Ala Thr Ala Leu Ala Ala Ile Arg Ala 
    290                 295                 300                 


Phe Glu Ala Glu Glu Ser Glu Arg Ala Arg Arg Glu Ser Leu Gly Asn 
305                 310                 315                 320 


Glu Gly Thr Gly Tyr Arg Ile Gly Gly Arg Glu Leu Arg Asp Ala Trp 
                325                 330                 335     


Thr Leu Leu Arg Asp Trp Leu Lys Gly His Ser Thr Ala Thr Ala Ala 
            340                 345                 350         


Ala Arg Glu Asp Lys Val Arg Glu Leu Gln Ala Lys Gln Gly Arg Ser 
        355                 360                 365             


Phe Gly Ser His Arg Leu Leu Ser Trp Leu Ala Lys Pro Ala Gln Gln 
    370                 375                 380                 


Trp Leu Ala Asp His Ser Ala Gly Asp Val Val Thr Arg Ile Ala Val 
385                 390                 395                 400 


Arg Asn Ala Arg Gln Arg Lys Leu Asp Thr Ala Arg Thr Leu Pro Ile 
                405                 410                 415     


Trp Thr Gly Ala Asp Ala Val Lys His Pro Arg Phe Ala Asn Phe Asp 
            420                 425                 430         


Pro Pro Asn Asn Thr Asn Gln Pro Gly Phe Asp Leu Arg Ala Gly Thr 
        435                 440                 445             


Gln Lys Gly Arg Leu Thr Leu Arg Leu Ser Leu Leu Thr Glu Arg Ala 
    450                 455                 460                 


Asp Gly Leu Leu Leu Ala Gln Asp His Asp Phe Gln Leu Val Pro Ser 
465                 470                 475                 480 


Arg Gln Met Ala Glu Ile Val Leu His Lys Asp Gly Lys Glu Arg Ala 
                485                 490                 495     


Leu Ser Trp Gln Ser Gln Asp Gly Ile Gly Arg Gln Val Gly Asp Val 
            500                 505                 510         


Gly Gly Ser Ala Leu Leu Phe Ser Arg Asp His Ala Glu Cys Leu Leu 
        515                 520                 525             


Glu Arg Lys Gln Ile Thr Arg Leu Glu Arg Gly Ala Trp Pro Ala Ala 
    530                 535                 540                 


Leu Pro Val Trp Phe Lys Leu Ser Leu Asp Ile Gly Ala Glu His Lys 
545                 550                 555                 560 


Ala Leu Leu Lys Gln Arg Phe Lys Trp Gly Val Trp Leu Asn Ser Ala 
                565                 570                 575     


Leu Val Thr Arg Asn Ala Lys Asp Ala Lys Gly Val Pro Pro Pro Val 
            580                 585                 590         


Gly Thr Arg Val Leu Ala Val Asp Leu Gly Leu Arg Ser Ala Ala Thr 
        595                 600                 605             


Val Ser Val Trp Gln Val Val Asp Ala Ala Thr Pro Val Val Ala Gly 
    610                 615                 620                 


Lys Trp Arg Val Pro Leu Ser Asp Thr Leu Ser Ala Val His Glu Arg 
625                 630                 635                 640 


Ser Ala Met Leu Ala Leu Pro Gly Glu His Val Asp Ala Gly Val Leu 
                645                 650                 655     


Ala Ala Arg Arg Ala Ala Asn Glu Lys Leu Ala Gly Leu Leu Ala Ala 
            660                 665                 670         


Thr Ser His Leu Ser Thr Val Phe Lys Leu Gly Arg Ala Glu Gln Gly 
        675                 680                 685             


Asp Arg Arg Arg Glu Leu Leu Glu Arg Leu Gly Glu Gly Asp Asp Arg 
    690                 695                 700                 


Arg Ala Arg Ala Ala Val Ala Thr Thr Ala Ala Glu Arg Asp Gly Leu 
705                 710                 715                 720 


Arg Ala Val Leu Gly Ala Thr Gln Asp Ala Trp Ala Gly Ala Val Ala 
                725                 730                 735     


Ala Val Trp Arg Arg Leu Glu Thr Asp Leu Ala Gly Ala Ile Ala Ala 
            740                 745                 750         


Tyr Arg Lys Gln Gln Arg Glu Asp Val Gln Leu Arg Arg Glu Ala Arg 
        755                 760                 765             


His Gly Pro Gly Ala Ser Gln Leu Pro Lys Gln Ala Ala Ala Glu Arg 
    770                 775                 780                 


Leu Leu Gly Gly Lys Ser Ala Trp Gln Ile Glu Tyr Lys Glu Arg Val 
785                 790                 795                 800 


Arg Lys Leu Leu Thr Arg Trp Ile Met Arg Gln Arg Pro Gly Asp Thr 
                805                 810                 815     


Ala Val Arg Arg Leu Ala Arg Lys Asp Leu Gly Lys Tyr Cys Gly Gly 
            820                 825                 830         


Leu Leu Asp His Leu Thr Ala Leu Lys Glu Asp Arg Ala Lys Thr Thr 
        835                 840                 845             


Ala Asp Leu Ile Val Gln Ala Ala Arg Gly Arg Val Arg Ala His Lys 
    850                 855                 860                 


Asp Ala His Gly Arg Gln Gln Asp Arg Glu Leu Trp Leu Ala Lys Tyr 
865                 870                 875                 880 


Ala Pro Cys Asp Leu Ile Val Met Glu Asp Leu Gly Arg Tyr Arg Phe 
                885                 890                 895     


Ala Thr Asp Arg Pro Pro Ser Glu Asn Arg Gln Leu Met Gln Trp Thr 
            900                 905                 910         


His Arg Glu Val Phe Arg Leu Val Gln Met Gln Ala Glu Val Glu Gly 
        915                 920                 925             


Ile Gln Val Leu Glu Thr Gly Ala Glu Phe Ser Ser Lys Phe Asp Ala 
    930                 935                 940                 


Arg Thr Trp Ala Pro Gly Val Arg Cys Glu Pro Ile Thr Lys Leu Trp 
945                 950                 955                 960 


Val Glu Arg Tyr Arg Asn Gly Glu Met Pro Trp Leu Ala Asp Lys Ala 
                965                 970                 975     


Asp Glu Trp Arg Arg Glu Gly Ile Glu Leu Ala Gln Leu Val Pro Gly 
            980                 985                 990         


Gln Leu Leu Pro Thr Gly Ser Gly  Glu Gln Phe Val Ala  Val Ser Ala 
        995                 1000                 1005             


Thr Gly  Gly Leu Arg Val Arg  His Ala Asp Leu Asn  Ala Ala Gln 
    1010                 1015                 1020             


Cys Ile  Ala Leu Arg Ala Leu  Thr Gly His Gly Thr  Ala Phe Arg 
    1025                 1030                 1035             


Leu Thr  Ala Arg Arg Leu Gly  Asp Val Phe Val Ser  Ala Lys Gly 
    1040                 1045                 1050             


Leu Gly  Lys Arg Pro Gln Gly  Ala Leu Trp Arg Glu  Phe Gly Ser 
    1055                 1060                 1065             


Ala Leu  Pro Pro Ala Val Val  Val Leu Arg Pro Ala  Gly Glu Val 
    1070                 1075                 1080             


Arg Tyr  Ala Leu Arg Pro Phe  Ala Ser Ala Arg Asp  Ala Ala Ala 
    1085                 1090                 1095             


Ala Leu  Gly Leu Gln Leu Gly  Ala Leu Arg Asn Val  Asp Ala Thr 
    1100                 1105                 1110             


Asp Ala  Glu Ser Asp Ala Glu  Asp Gly Asp Leu Ala  Glu Leu Leu 
    1115                 1120                 1125             


Ala Gly  Ala Asp Pro Asp Arg  Ala Thr Phe Phe Arg  Asp Pro Ser 
    1130                 1135                 1140             


Gly Asp  Val His Gly Gly Ala  Trp Val Gln Ala Lys  Val Phe Trp 
    1145                 1150                 1155             


Ala Glu  Val Arg Arg His Val  Arg Leu Gly Leu Gln  Ala Gln Gly 
    1160                 1165                 1170             


Leu Leu  Pro Ala Ala Ala Arg  Ser Ser Glu Pro Arg  Gln Met Gln 
    1175                 1180                 1185             


Leu Pro  Leu Ala Gly Ala Leu  Pro Gly Asp Asp Ile  Pro Leu 
    1190                 1195                 1200         


<210> 626
<211> 1397
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 626
Met Ala Ala Phe Gln Arg Ser Tyr Thr Met Asn Leu Lys Pro Ala Thr 
1               5                   10                  15      


Ser Glu Gln Asp Lys Phe Ile Leu Trp Asn Arg Leu Phe Leu Thr His 
            20                  25                  30          


Trp Ser Val Asn Glu Gly Ala Lys Ile Phe Gly Glu Leu Phe Leu Asn 
        35                  40                  45              


Leu Arg Gly Gly Leu Ser Pro Glu Leu Gly Ile Phe Asp Leu Asn Lys 
    50                  55                  60                  


Asp Lys Asp Asp Arg Lys Lys Lys Ala Leu Val Met Gly Arg Arg Arg 
65                  70                  75                  80  


Leu Leu Ala Leu Gly Trp Leu Ser Val Glu Asp Asn Leu Ser Ala Gly 
                85                  90                  95      


Asp His Pro Phe Arg Ile Arg Glu Ile Pro Val Gly Arg Asn Met Glu 
            100                 105                 110         


Ile Lys Gln Ala Thr Thr Leu Leu Thr Glu Ile Leu Lys Asn Lys Gly 
        115                 120                 125             


Val Lys Asp Glu Ala Val Ile Lys Glu Trp Ile Asp Asp Cys Thr Pro 
    130                 135                 140                 


Ser Leu Ile Ala Asn Ile Arg Glu Asp Ala Val Trp Ile Asn Arg Ala 
145                 150                 155                 160 


Lys Ser Phe Tyr Ser Met Asn Pro Cys Pro Thr Lys Asp Glu Val Trp 
                165                 170                 175     


Lys Ile Leu Ser Tyr Val Leu Asn Thr Ser Phe Leu Asp Leu Ser Leu 
            180                 185                 190         


Asn Asp Ser Ser Glu Arg Asp Asn Thr Lys Asn Lys Lys Gly Thr Lys 
        195                 200                 205             


Glu Asn Glu Lys Asp Val Ser Asn Lys Ser Lys Glu Leu Tyr Gly Trp 
    210                 215                 220                 


Leu Phe Thr Lys Asn Pro Asn Lys Met Arg Glu Ala Gly Glu Asn Lys 
225                 230                 235                 240 


Asp Lys Phe Ile Asn Asn Phe Arg Glu Asn Phe Asn Thr Phe Thr Asp 
                245                 250                 255     


Tyr Ala Asn Leu Lys Val Glu Ile Glu Leu Trp Arg Lys Asn Asn Ile 
            260                 265                 270         


Ser Asn Thr Leu Leu Ile Thr Gln Lys Ala Lys Tyr Pro Pro Glu Val 
        275                 280                 285             


Lys Glu Ala Asn His Pro Ser Lys Phe Ser Val Gly Tyr Arg Lys Leu 
    290                 295                 300                 


Leu Val His Leu Glu Leu Trp Pro Ser Ser Lys Asp Glu Asn Gly Asp 
305                 310                 315                 320 


Ile Pro Lys Gly Ile Glu Gly Lys Asp Lys Ser His Asn Gln Ile Leu 
                325                 330                 335     


Leu Asp Tyr Leu Leu Glu Val Cys Asn Glu Gly Asn Lys Thr Thr Lys 
            340                 345                 350         


Lys Val Ile Val Pro Ala Trp Ala Asp Gly Ile Lys Thr Glu Leu Glu 
        355                 360                 365             


Ser Lys Ala Ser Ile Lys Val Gly Asp Ser Thr Ser Ser Val Leu Gln 
    370                 375                 380                 


Arg Leu Met Ile Lys Met Ala Ala Arg Arg Ile Ser Gln Thr Leu Ser 
385                 390                 395                 400 


Trp Ile Lys Ile Asn Glu Gln Val Arg His Asp Ala Tyr Gln Lys Lys 
                405                 410                 415     


Asn Lys Ala Phe Lys Leu Leu Cys Glu Ile Asp Lys Asn Gly Glu Ala 
            420                 425                 430         


Cys Lys Trp Leu Glu Asn Tyr Glu Leu Phe Arg Arg Asp Asp Ser Gly 
        435                 440                 445             


Gly Glu Glu Tyr His Ile Ser Ala Arg Ala Ile Ser Cys Trp Lys Gln 
    450                 455                 460                 


Ile Leu Glu Glu Trp Gln Lys Asn Asp Ser Ser Lys Ala Leu Arg Glu 
465                 470                 475                 480 


Lys Val Lys Val Val Gln Ala Ala Glu Asp Lys Phe Gly Asp Ala Arg 
                485                 490                 495     


Leu Phe Glu Asp Leu Ala Asp Asp Asn Ala Arg Ser Val Trp Leu Leu 
            500                 505                 510         


Pro Asp Gly Asn Lys Thr Pro Asp Ile Leu Asn Trp Trp Cys Glu Tyr 
        515                 520                 525             


Arg Thr Ala Asp Ile Asp Glu Ser Arg Phe Lys Ile Pro Cys Tyr Cys 
    530                 535                 540                 


His Pro His Pro Phe Lys His Pro Val Tyr Val Glu Tyr Gly Lys Ser 
545                 550                 555                 560 


Asn Pro Gln Val Ile Phe Ser Leu Lys His Asp Lys Ala Arg Lys Asn 
                565                 570                 575     


Arg Ile Asp Asn Gly Trp Asn Pro Lys Asn Pro Arg Ile Leu Ala Leu 
            580                 585                 590         


Leu Leu Leu Asp Ile Val Arg Gln Lys Ser Thr Leu Ala Pro Phe Val 
        595                 600                 605             


Trp Glu Ser Lys Arg Leu Trp Lys Asp Leu Gly Gly Asp Ala Thr Val 
    610                 615                 620                 


Thr Tyr Lys Ile Pro Arg Ser Asp Arg Met Gly Leu Ser Ser Ile Gly 
625                 630                 635                 640 


Asn Ile Asp Tyr Ala Arg Pro Glu Val Pro Phe Leu Lys Glu Lys Trp 
                645                 650                 655     


Asn Ala Arg Leu Gln Ser Asp Arg Arg Thr Leu Glu Lys Leu Glu Lys 
            660                 665                 670         


Tyr Trp Asn Pro Glu Ser Met Lys Trp Ile Asp Asp Gly Lys Phe Leu 
        675                 680                 685             


Ile Gln Ser Lys Trp Phe Ile Thr Phe Gly Pro Asp Met Glu Thr Ala 
    690                 695                 700                 


Glu Gly Pro Trp Lys Leu Tyr Leu Lys Glu Asn Ile Asn Asp Asn Asn 
705                 710                 715                 720 


Tyr Leu Gly Asn Arg Ser Lys Glu Asn Gln Lys Arg Gly Tyr Arg Ala 
                725                 730                 735     


Lys Lys Leu Leu Ser Gly Tyr Pro Ala Gly Met Arg Ile Leu Ser Val 
            740                 745                 750         


Asp Leu Gly His Arg Tyr Ala Ala Ser Cys Ala Ile Trp Glu Thr Ile 
        755                 760                 765             


Thr Lys Lys Gln Ile Thr Glu Glu Leu Ala Tyr Gln Pro Asp Lys Asn 
    770                 775                 780                 


Ser Val Phe Glu His Ser Cys Lys Thr Ile Asp Lys Lys Ile Lys Asn 
785                 790                 795                 800 


Thr Val Tyr Arg Arg Ile Gly Asp Asp Ser Ile Asp Ala Pro Trp Ala 
                805                 810                 815     


Lys Leu Glu Lys Gln Phe Thr Ile Lys Leu Gln Gly Glu Asp Lys Ser 
            820                 825                 830         


Cys Tyr Leu Leu Arg Ser Asp Glu Lys Glu Leu Phe Arg Ser Ile Leu 
        835                 840                 845             


Ser Lys Leu Ser Cys Leu Asn Asn Asp Thr Gly His Asn Ile Leu Glu 
    850                 855                 860                 


Met Ile Glu Asn Leu Leu Arg Ile Val Lys Ala Lys Ile Tyr Arg Gln 
865                 870                 875                 880 


Gly Ile Leu Ala Arg Ile Ser Tyr Ser Met Thr Ala Gln Tyr Lys Pro 
                885                 890                 895     


Gly Lys Gly Gly Gln Lys Ser Pro Leu Ser Asp Glu Asp Lys Ile His 
            900                 905                 910         


Tyr Leu Ser Glu Asn Leu Ala Ala Trp Ser Ala Leu Met Gly Asn Gln 
        915                 920                 925             


Glu Trp Asn Glu Asp Gly Ile Ser Asp Trp Tyr Lys Lys Tyr Ile Ser 
    930                 935                 940                 


His Leu Val Ser Gly Pro Lys Pro Lys Glu Gly Asn Arg Lys Ser Asp 
945                 950                 955                 960 


Arg Asp Lys Ile Ile Glu Tyr Phe Leu Pro Ala Ala Arg Lys Leu Tyr 
                965                 970                 975     


Asp Asp Asn Glu Thr Arg Ile Asn Ile His Asp Leu Phe Lys Glu Leu 
            980                 985                 990         


Trp Asp Glu Asn Asn Lys Gln Leu  Ser Ala Val Leu Lys  Glu Ile Lys 
        995                 1000                 1005             


Lys Ile  Ile Leu Pro Lys Gly  Ile Arg Tyr Phe Asp  Lys Asn Asn 
    1010                 1015                 1020             


Asp Ser  Ser Ser Arg Trp Lys  Asn Asn Gln Ser Lys  Leu Lys Gln 
    1025                 1030                 1035             


Ile Thr  His Arg Gly Gly Leu  Ser Leu Arg Arg Ile  Val Ala Ile 
    1040                 1045                 1050             


Glu Gly  Tyr Tyr Lys Leu Ala  Lys Ala Tyr Lys Asn  His Pro Glu 
    1055                 1060                 1065             


Pro Asp  Asn Leu Thr Lys Asn  Ile Pro Leu Pro Gly  Asp Asn Ser 
    1070                 1075                 1080             


Ser Ala  Gly Phe Asn Gln Arg  Ile Arg Asp Thr Leu  Glu Arg Met 
    1085                 1090                 1095             


Lys Glu  Gln Arg Val Lys Gln  Ile Ala Ser Arg Ile  Val Glu Ser 
    1100                 1105                 1110             


Ala Leu  Gly Leu Gly Ile Glu  Gly Tyr Lys Lys Arg  Pro Leu Thr 
    1115                 1120                 1125             


Pro Glu  Ser Lys Pro Cys Gln  Ala Ile Val Ile Glu  Asp Leu Ser 
    1130                 1135                 1140             


His Tyr  Arg Pro Asp Glu Leu  Gln Thr Arg Arg Glu  Asn Arg Arg 
    1145                 1150                 1155             


Leu Met  Gln Trp Ser Ser Ser  Lys Val Lys Lys Tyr  Leu Ser Glu 
    1160                 1165                 1170             


Ala Cys  Glu Met His Asp Val  Leu Leu Val Glu Ile  Ser Pro Glu 
    1175                 1180                 1185             


Tyr Thr  Ser Arg Gln Asp Ser  Arg Thr Gly Val Ala  Gly Leu Arg 
    1190                 1195                 1200             


Cys Ile  Asp Ile Asn Ile Arg  Glu Phe Leu Lys Asp  Ser Ser Ser 
    1205                 1210                 1215             


Trp Gln  Asn Lys Ile Lys Thr  Ile Gln Met Lys Pro  Thr Asn Lys 
    1220                 1225                 1230             


Lys Ser  Asn Leu Asp Gln Tyr  Leu Ile Glu Leu Asn  Glu Ser Leu 
    1235                 1240                 1245             


Gly Glu  Arg Tyr Lys Asp Lys  Val Ile Pro Ser Asp  Lys Phe Val 
    1250                 1255                 1260             


Arg Ile  Pro Arg Lys Gly Gly  Asp Ile Phe Val Ser  Ser Ser Lys 
    1265                 1270                 1275             


Glu Ser  Pro Val Ser Lys Gly  Ile Gln Ala Asp Leu  Asn Ala Ala 
    1280                 1285                 1290             


Ala Asn  Ile Gly Leu Lys Ala  Leu Leu Asp Pro Asp  Trp Ala Gly 
    1295                 1300                 1305             


Ala Trp  Trp Tyr Ile Leu Ile  Glu Ala Lys Ser Asn  His Val Ile 
    1310                 1315                 1320             


Pro Tyr  Gly Lys Lys Tyr Lys  Gly Ala Glu Cys Leu  Arg Asp Phe 
    1325                 1330                 1335             


Lys Phe  Ser Gly Leu Glu Asn  Gln Val Met Lys Asn  Asn Met Asn 
    1340                 1345                 1350             


Leu Trp  Arg Asp Leu Gln Ser  Gln Phe Ser Ser Glu  Asp Lys Trp 
    1355                 1360                 1365             


Met Ser  Tyr Lys Glu Tyr Asn  Glu Leu Thr Glu Lys  Arg Val Ile 
    1370                 1375                 1380             


Asn Ile  Leu Arg Glu Arg Ala  Gly Leu Glu Leu Ile  Glu Glu 
    1385                 1390                 1395         


<210> 627
<211> 1203
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 627
Met Pro Thr Arg Thr Ile Asn Leu Lys Met Val Leu Gly Arg Lys Asp 
1               5                   10                  15      


Asp Thr Ala Glu Leu Arg Arg Ala Leu Trp Thr Thr His Glu His Val 
            20                  25                  30          


Asn Leu Ala Val Ala Glu Val Glu Arg Val Leu Leu Arg Cys Arg Gly 
        35                  40                  45              


Arg Ser Tyr Trp Thr Leu Asp Arg Arg Gly Asp Pro Val His Val Pro 
    50                  55                  60                  


Glu Ser Gln Val Ala Glu Asp Ala Leu Ala Met Ala Arg Glu Ala Gln 
65                  70                  75                  80  


Arg Arg Asn Gly Trp Pro Val Val Gly Glu Asp Glu Glu Ile Leu Leu 
                85                  90                  95      


Ala Leu Arg Tyr Leu Tyr Glu Gln Ile Val Pro Ser Cys Leu Leu Asp 
            100                 105                 110         


Asp Leu Gly Lys Pro Leu Lys Gly Asp Ala Gln Lys Ile Gly Thr Asn 
        115                 120                 125             


Tyr Ala Gly Pro Leu Phe Asp Ser Asp Thr Cys Arg Arg Asp Glu Gly 
    130                 135                 140                 


Lys Asp Val Ala Cys Cys Gly Pro Phe His Glu Val Ala Gly Lys Tyr 
145                 150                 155                 160 


Leu Gly Ala Leu Pro Glu Trp Ala Thr Pro Ile Ser Lys Gln Glu Phe 
                165                 170                 175     


Asp Gly Lys Asp Ala Ser His Leu Arg Phe Lys Ala Thr Gly Gly Asp 
            180                 185                 190         


Asp Ala Phe Phe Arg Val Ser Ile Glu Lys Ala Asn Ala Trp Tyr Glu 
        195                 200                 205             


Asp Pro Ala Asn Gln Asp Ala Leu Lys Asn Lys Ala Tyr Asn Lys Asp 
    210                 215                 220                 


Asp Trp Lys Lys Glu Lys Asp Lys Gly Ile Ser Ser Trp Ala Val Lys 
225                 230                 235                 240 


Tyr Ile Gln Lys Gln Leu Gln Leu Gly Gln Asp Pro Arg Thr Glu Val 
                245                 250                 255     


Arg Arg Lys Leu Trp Leu Glu Leu Gly Leu Leu Pro Leu Phe Ile Pro 
            260                 265                 270         


Val Phe Asp Lys Thr Met Val Gly Asn Leu Trp Asn Arg Leu Ala Val 
        275                 280                 285             


Arg Leu Ala Leu Ala His Leu Leu Ser Trp Glu Ser Trp Asn His Arg 
    290                 295                 300                 


Ala Val Gln Asp Gln Ala Leu Ala Arg Ala Lys Arg Asp Glu Leu Ala 
305                 310                 315                 320 


Ala Leu Phe Leu Gly Met Glu Asp Gly Phe Ala Gly Leu Arg Glu Tyr 
                325                 330                 335     


Glu Leu Arg Arg Asn Glu Ser Ile Lys Gln His Ala Phe Glu Pro Val 
            340                 345                 350         


Asp Arg Pro Tyr Val Val Ser Gly Arg Ala Leu Arg Ser Trp Thr Arg 
        355                 360                 365             


Val Arg Glu Glu Trp Leu Arg His Gly Asp Thr Gln Glu Ser Arg Lys 
    370                 375                 380                 


Asn Ile Cys Asn Arg Leu Gln Asp Arg Leu Arg Gly Lys Phe Gly Asp 
385                 390                 395                 400 


Pro Asp Val Phe His Trp Leu Ala Glu Asp Gly Gln Glu Ala Leu Trp 
                405                 410                 415     


Lys Glu Arg Asp Cys Val Thr Ser Phe Ser Leu Leu Asn Asp Ala Asp 
            420                 425                 430         


Gly Leu Leu Glu Lys Arg Lys Gly Tyr Ala Leu Met Thr Phe Ala Asp 
        435                 440                 445             


Ala Arg Leu His Pro Arg Trp Ala Met Tyr Glu Ala Pro Gly Gly Ser 
    450                 455                 460                 


Asn Leu Arg Thr Tyr Gln Ile Arg Lys Thr Glu Asn Gly Leu Trp Ala 
465                 470                 475                 480 


Asp Val Val Leu Leu Ser Pro Arg Asn Glu Ser Ala Ala Val Glu Glu 
                485                 490                 495     


Lys Thr Phe Asn Val Arg Leu Ala Pro Ser Gly Gln Leu Ser Asn Val 
            500                 505                 510         


Ser Phe Asp Gln Ile Gln Lys Gly Ser Lys Met Val Gly Arg Cys Arg 
        515                 520                 525             


Tyr Gln Ser Ala Asn Gln Gln Phe Glu Gly Leu Leu Gly Gly Ala Glu 
    530                 535                 540                 


Ile Leu Phe Asp Arg Lys Arg Ile Ala Asn Glu Gln His Gly Ala Thr 
545                 550                 555                 560 


Asp Leu Ala Ser Lys Pro Gly His Val Trp Phe Lys Leu Thr Leu Asp 
                565                 570                 575     


Val Arg Pro Gln Ala Pro Gln Gly Trp Leu Asp Gly Lys Gly Arg Pro 
            580                 585                 590         


Ala Leu Pro Pro Glu Ala Lys His Phe Lys Thr Ala Leu Ser Asn Lys 
        595                 600                 605             


Ser Lys Phe Ala Asp Gln Val Arg Pro Gly Leu Arg Val Leu Ser Val 
    610                 615                 620                 


Asp Leu Gly Val Arg Ser Phe Ala Ala Cys Ser Val Phe Glu Leu Val 
625                 630                 635                 640 


Arg Gly Gly Pro Asp Gln Gly Thr Tyr Phe Pro Ala Ala Asp Gly Arg 
                645                 650                 655     


Thr Val Asp Asp Pro Glu Lys Leu Trp Ala Lys His Glu Arg Ser Phe 
            660                 665                 670         


Lys Ile Thr Leu Pro Gly Glu Asn Pro Ser Arg Lys Glu Glu Ile Ala 
        675                 680                 685             


Arg Arg Ala Ala Met Glu Glu Leu Arg Ser Leu Asn Gly Asp Ile Arg 
    690                 695                 700                 


Arg Leu Lys Ala Ile Leu Arg Leu Ser Val Leu Gln Glu Asp Asp Pro 
705                 710                 715                 720 


Arg Thr Glu His Leu Arg Leu Phe Met Glu Ala Ile Val Asp Asp Pro 
                725                 730                 735     


Ala Lys Ser Ala Leu Asn Ala Glu Leu Phe Lys Gly Phe Gly Asp Asp 
            740                 745                 750         


Arg Phe Arg Ser Thr Pro Asp Leu Trp Lys Gln His Cys His Phe Phe 
        755                 760                 765             


His Asp Lys Ala Glu Lys Val Val Ala Glu Arg Phe Ser Arg Trp Arg 
    770                 775                 780                 


Thr Glu Thr Arg Pro Lys Ser Ser Ser Trp Gln Asp Trp Arg Glu Arg 
785                 790                 795                 800 


Arg Gly Tyr Ala Gly Gly Lys Ser Tyr Trp Ala Val Thr Tyr Leu Glu 
                805                 810                 815     


Ala Val Arg Gly Leu Ile Leu Arg Trp Asn Met Arg Gly Arg Thr Tyr 
            820                 825                 830         


Gly Glu Val Asn Arg Gln Asp Lys Lys Gln Phe Gly Thr Val Ala Ser 
        835                 840                 845             


Ala Leu Leu His His Ile Asn Gln Leu Lys Glu Asp Arg Ile Lys Thr 
    850                 855                 860                 


Gly Ala Asp Met Ile Ile Gln Ala Ala Arg Gly Phe Val Pro Arg Lys 
865                 870                 875                 880 


Asn Gly Ala Gly Trp Val Gln Val His Glu Pro Cys Arg Leu Ile Leu 
                885                 890                 895     


Phe Glu Asp Leu Ala Arg Tyr Arg Phe Arg Thr Asp Arg Ser Arg Arg 
            900                 905                 910         


Glu Asn Ser Arg Leu Met Arg Trp Ser His Arg Glu Ile Val Asn Glu 
        915                 920                 925             


Val Gly Met Gln Gly Glu Leu Tyr Gly Leu His Val Asp Thr Thr Glu 
    930                 935                 940                 


Ala Gly Phe Ser Ser Arg Tyr Leu Ala Ser Ser Gly Ala Pro Gly Val 
945                 950                 955                 960 


Arg Cys Arg His Leu Val Glu Glu Asp Phe His Asp Gly Leu Pro Gly 
                965                 970                 975     


Met His Leu Val Gly Glu Leu Asp Trp Leu Leu Pro Lys Asp Lys Asp 
            980                 985                 990         


Arg Thr Ala Asn Glu Ala Arg Arg  Leu Leu Gly Gly Met  Val Arg Pro 
        995                 1000                 1005             


Gly Met  Leu Val Pro Trp Asp  Gly Gly Glu Leu Phe  Ala Thr Leu 
    1010                 1015                 1020             


Asn Ala  Ala Ser Gln Leu His  Val Ile His Ala Asp  Ile Asn Ala 
    1025                 1030                 1035             


Ala Gln  Asn Leu Gln Arg Arg  Phe Trp Gly Arg Cys  Gly Glu Ala 
    1040                 1045                 1050             


Ile Arg  Ile Val Cys Asn Gln  Leu Ser Val Asp Gly  Ser Thr Arg 
    1055                 1060                 1065             


Tyr Glu  Met Ala Lys Ala Pro  Lys Ala Arg Leu Leu  Gly Ala Leu 
    1070                 1075                 1080             


Gln Gln  Leu Lys Asn Gly Asp  Ala Pro Phe His Leu  Thr Ser Ile 
    1085                 1090                 1095             


Pro Asn  Ser Gln Lys Pro Glu  Asn Ser Tyr Val Met  Thr Pro Thr 
    1100                 1105                 1110             


Asn Ala  Gly Lys Lys Tyr Arg  Ala Gly Pro Gly Glu  Lys Ser Ser 
    1115                 1120                 1125             


Gly Glu  Glu Asp Glu Leu Ala  Leu Asp Ile Val Glu  Gln Ala Glu 
    1130                 1135                 1140             


Glu Leu  Ala Gln Gly Arg Lys  Thr Phe Phe Arg Asp  Pro Ser Gly 
    1145                 1150                 1155             


Val Phe  Phe Ala Pro Asp Arg  Trp Leu Pro Ser Glu  Ile Tyr Trp 
    1160                 1165                 1170             


Ser Arg  Ile Arg Arg Arg Ile  Trp Gln Val Thr Leu  Glu Arg Asn 
    1175                 1180                 1185             


Ser Ser  Gly Arg Gln Glu Arg  Ala Glu Met Asp Glu  Met Pro Tyr 
    1190                 1195                 1200             


<210> 628
<211> 1097
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 628
Met Val Thr Arg Ala Leu Asn Leu Lys Leu Val Val Pro Arg Arg Pro 
1               5                   10                  15      


Gly Glu Leu Thr Lys Ala Glu Ala Leu Trp Ser Thr His Asp Ile Val 
            20                  25                  30          


Asn Arg Ala Thr Ser Tyr Tyr Glu Ser Gln Leu Leu Leu Cys Arg Gln 
        35                  40                  45              


Gln Asp Tyr Gln Thr Arg Glu Leu Thr Val Ser Ala Gly Asp Gln Ala 
    50                  55                  60                  


Pro Asp Leu Asp Ala Leu Ile Ala Asn Ala Arg Asp Arg Asn Arg Tyr 
65                  70                  75                  80  


Arg Gly Leu Glu Lys Pro Gln Val Val Arg Glu Lys Leu Arg Asn Leu 
                85                  90                  95      


Tyr Glu Ala Ile Val Pro Pro Ala Ile Gly Lys Thr Gly Thr Ala Gln 
            100                 105                 110         


Ala Val Gly Ala Phe Val Ser Pro Leu Leu Asp Ala Asp Ser Arg Gly 
        115                 120                 125             


Phe Thr Glu Ile Phe Asp Lys Ile Glu Ala Leu Pro Asn Trp Val Asp 
    130                 135                 140                 


Gly Val Arg Ala Glu Glu Pro Asp Ala Leu Glu Ala Ala Ala Asp Trp 
145                 150                 155                 160 


Leu Lys Ser Pro Gln Gly Lys Glu Arg Leu Arg Pro Thr Gly Ala Pro 
                165                 170                 175     


Pro Thr Trp Ile Lys Leu Ala Lys Lys Lys Asp Ala Gly Trp Ala Ala 
            180                 185                 190         


Ala Phe Val Ala Asp Ile Asp Lys Lys Leu Lys Glu Val Glu Gly Thr 
        195                 200                 205             


Pro Thr Leu Met Gln Glu Leu Arg Ala Leu Gly Val Met Pro Leu Phe 
    210                 215                 220                 


Pro Ser Phe Phe Ala Ser Arg Ile Ala Gly His Lys Gly Ala Val Ser 
225                 230                 235                 240 


Thr Trp Asp Arg Leu Ala Leu Arg Leu Ala Val Ala His Leu Leu Ser 
                245                 250                 255     


Trp Glu Ser Trp Val Glu Leu Ala Ala Lys Glu His Ala Ala Arg Val 
            260                 265                 270         


Ala Lys Leu Glu Lys Phe Arg Asp Asp Asn Ile Leu Gly Glu Ile Ala 
        275                 280                 285             


Asp Ala Val Glu Ala Leu Arg Leu Tyr Glu Lys Glu Arg Thr Glu Glu 
    290                 295                 300                 


Leu Gln Gln Lys Ala Gln Leu Asp Ala Glu Glu Val Arg Thr Thr Ser 
305                 310                 315                 320 


Arg Thr Ile Arg Gly Trp Val Asp Leu Arg Glu Lys Trp Leu Lys Thr 
                325                 330                 335     


Asp Ala Ser Pro Asp Ala Leu Ile Ser Leu Val Ala Ala Glu Gln Lys 
            340                 345                 350         


Arg Lys Ser Gly Lys Phe Gly Asp Pro Gln Leu Phe Arg Trp Leu Ala 
        355                 360                 365             


Lys Pro Glu Asn His Phe Val Trp Asn Lys Pro Asp Phe Asp Pro Pro 
    370                 375                 380                 


Ser Leu Phe Ala Ser Leu Arg Met Ile Glu Gly Leu Val Glu Arg Ser 
385                 390                 395                 400 


Lys Glu Thr Ala Trp Met Thr Leu Pro Asp Ala Arg Leu His Pro Arg 
                405                 410                 415     


Ser Ser Gln Trp Glu Pro His Gly Gly Gly Asn Leu Lys Thr Phe Arg 
            420                 425                 430         


Leu Glu Gln Gly Glu Gly Gly Ser Leu Ser Val Thr Leu Pro Leu Leu 
        435                 440                 445             


Arg Lys Ser Gly Asp Asp Ser Tyr Val Glu Glu Glu His Ala Phe Ser 
    450                 455                 460                 


Leu Ala Gly Ser Lys Gln Ile Pro Asn Ala Ser Leu Asp Val Arg Arg 
465                 470                 475                 480 


Asn Lys Tyr Cys Leu Ser Tyr Arg Thr Pro Thr Gly Glu Glu Ala Glu 
                485                 490                 495     


Ala Val Val Gly Ser Ala Asp Leu Leu Leu Asp Trp Tyr Phe Leu Gln 
            500                 505                 510         


Gln Arg Ser Glu His Arg Pro Glu Glu Gly Asp Ile Gly Pro Ala Phe 
        515                 520                 525             


Leu Lys Leu Ala Leu Asp Ile Thr Pro Ile Asp Pro Val Trp Gly Glu 
    530                 535                 540                 


Arg Glu Lys Thr Pro Ala Ile His His Phe Lys Thr Ala Ser Gly Lys 
545                 550                 555                 560 


Asn Thr Arg His Ala Asp Gly Val Ala Pro Gly Phe Arg Met Leu Ala 
                565                 570                 575     


Val Asp Leu Gly Ile Arg Thr Leu Ala Thr Cys Ser Val Phe Glu Leu 
            580                 585                 590         


Lys Ala Thr Ala Pro Ala Gly Arg Leu Ser Phe Pro Ile Ala His Leu 
        595                 600                 605             


Asp Leu His Ala Val His Glu Arg Ser Phe Thr Leu Thr Leu Asp Gly 
    610                 615                 620                 


Glu Asp Pro Asp Arg Asp Ala Glu Arg Trp Arg Glu Asn Lys Ser Ala 
625                 630                 635                 640 


Glu Leu Arg Arg Leu Arg Met Gly Leu Thr Arg Tyr Arg Asn Ile Arg 
                645                 650                 655     


Asn Met Arg Glu Asp Ala Pro Asp Glu Arg Glu Val Leu Leu Glu Asp 
            660                 665                 670         


Leu Gln Glu Lys Val Gln Glu His Gly Trp Ala Phe Glu Glu Pro Leu 
        675                 680                 685             


Leu Arg Glu Leu Ala Lys His Lys Asp Thr Pro Glu Pro Ile Trp Glu 
    690                 695                 700                 


Ala Glu Leu Thr Lys Ala Leu Ala Gln Phe Arg Ser Asp Phe Gly Val 
705                 710                 715                 720 


Ile Val Gly Glu Trp Arg Arg Ser Asn Arg Ala Arg Ser Thr Asp Ser 
                725                 730                 735     


His Ala Gly Lys Ser Met Trp Ala Ile Asp His Leu Thr Asn Ser Arg 
            740                 745                 750         


Arg Phe Leu Met Ser Trp Ser Leu Leu Ser Lys Pro Gly Gln Ile Arg 
        755                 760                 765             


Arg Leu Asp Arg Asp Lys Gln Gly Val Phe Ala Lys His Leu Leu Asp 
    770                 775                 780                 


His Leu Glu Gly Leu Lys Ala Asp Arg Leu Lys Thr Gly Ser Asp Leu 
785                 790                 795                 800 


Ile Val Gln Ala Ala Arg Gly Phe Arg Arg Asp Lys Arg Gly Asn Trp 
                805                 810                 815     


His Lys Ala Tyr Lys Pro Cys His Gly Ile Leu Phe Glu Asp Leu Ser 
            820                 825                 830         


Arg Tyr Arg Met Arg Thr Asp Arg Pro Arg Arg Glu Asn Ser Gln Leu 
        835                 840                 845             


Met Lys Trp Ala His Arg Ala Val Pro Lys Glu Val Gly Met Gln Ala 
    850                 855                 860                 


Glu Val Tyr Gly Ile Arg Val Glu Asp Thr Gly Ala Ala Phe Ser Ser 
865                 870                 875                 880 


Arg Phe His Ala Ala Ser His Thr Pro Gly Ile Arg Met His Pro Ile 
                885                 890                 895     


Cys Gln Lys Asp Leu Glu Asn Glu Trp Leu Leu Asp Glu Ile Glu Lys 
            900                 905                 910         


Gln Asn Ser Gly Val Lys Arg Arg Glu Leu Lys Leu Gly Gln Leu Val 
        915                 920                 925             


Gln Leu Asn Gly Gly Glu Leu Phe Ala Cys Val Thr Ala Ser Gly Val 
    930                 935                 940                 


Lys Thr Leu His Ala Asp Ile Asn Ala Ala Gln Asn Leu Gln Arg Arg 
945                 950                 955                 960 


Phe Phe Thr Arg His Gly Asp Ala Phe Arg Ile Val Ala Arg Lys Val 
                965                 970                 975     


Leu Val Asp Glu Glu Glu Val Trp Val Pro Arg Ser Leu Gly Lys Arg 
            980                 985                 990         


Leu Leu Gly Ala Leu Gly Ser His  Gly Lys Leu Val Pro  Thr Gly His 
        995                 1000                 1005             


Glu Ser  Gly Ser Cys Arg Phe  Glu Glu Ile Thr Thr  Arg Ala Trp 
    1010                 1015                 1020             


Ser Lys  Leu Ser Gly Glu Lys  Leu Ser Asp Asp Arg  Val Gly Asn 
    1025                 1030                 1035             


Glu Glu  Asp Gln Ile Ile Ala  Ser Ile Glu Glu Glu  Ala Leu Glu 
    1040                 1045                 1050             


Arg Thr  Gly Glu Val Val Val  Phe Phe Arg Asp Pro  Ser Gly Gln 
    1055                 1060                 1065             


Val Leu  Pro Arg Asp Leu Trp  Tyr Pro Ser Lys Thr  Phe Trp Ser 
    1070                 1075                 1080             


Ile Val  Lys Ser Thr Thr Leu  Ser Lys Leu Lys Ala  Ala Pro 
    1085                 1090                 1095         


<210> 629
<211> 1272
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 629
Met Glu Asp Lys Gln Phe Leu Glu Arg Tyr Lys Glu Phe Ile Gly Leu 
1               5                   10                  15      


Asn Ser Leu Ser Lys Thr Leu Arg Asn Ser Leu Ile Pro Val Gly Ser 
            20                  25                  30          


Thr Leu Lys His Ile Gln Glu Tyr Gly Ile Leu Glu Glu Asp Ser Leu 
        35                  40                  45              


Arg Ala Gln Lys Arg Glu Glu Leu Lys Gly Ile Met Asp Asp Tyr Tyr 
    50                  55                  60                  


Arg Asn Tyr Ile Glu Met His Leu Arg Asp Val His Asp Ile Asp Trp 
65                  70                  75                  80  


Asn Glu Leu Phe Glu Ala Leu Thr Glu Val Lys Lys Asn Gln Thr Asp 
                85                  90                  95      


Asp Ala Lys Lys Cys Leu Glu Lys Ile Gln Glu Lys Lys Arg Lys Glu 
            100                 105                 110         


Ile Tyr Gln Tyr Leu Ser Asp Asp Ala Val Phe Ser Glu Met Phe Lys 
        115                 120                 125             


Glu Lys Met Ile Ser Gly Ile Leu Pro Asp Phe Ile Arg Cys Asn Glu 
    130                 135                 140                 


Glu Tyr Ser Glu Glu Glu Lys Glu Glu Lys Leu Lys Thr Val Ala Leu 
145                 150                 155                 160 


Phe His Arg Phe Thr Ser Ser Phe Asn Asp Phe Phe Leu Asn Arg Lys 
                165                 170                 175     


Asn Val Phe Thr Lys Glu Ala Ile Ala Thr Ala Ile Gly Tyr Arg Val 
            180                 185                 190         


Val His Glu Asn Ala Glu Ile Phe Leu Glu Asn Met Val Ala Phe Gln 
        195                 200                 205             


Asn Ile Gln Lys Ser Ala Glu Ser Gln Ile Ser Ile Ile Glu Arg Lys 
    210                 215                 220                 


Asn Glu His Tyr Phe Met Glu Trp Lys Leu Ser His Ile Phe Thr Ala 
225                 230                 235                 240 


Asp Tyr Tyr Met Met Leu Met Thr Gln Lys Ala Ile Glu His Tyr Asn 
                245                 250                 255     


Glu Met Cys Gly Val Val Asn Gln His Met Lys Glu Tyr Cys Gln Lys 
            260                 265                 270         


Glu Lys Lys Asn Trp Asn Leu Tyr Arg Met Lys Arg Leu His Lys Gln 
        275                 280                 285             


Ile Leu Ser Asn Ala Ser Thr Ser Phe Lys Ile Pro Glu Lys Tyr Glu 
    290                 295                 300                 


Asn Asp Ala Glu Val Tyr Glu Ser Val Asn Ser Phe Leu Gln Asn Val 
305                 310                 315                 320 


Met Glu Lys Thr Val Met Glu Arg Ile Ala Val Leu Lys Asn Asn Thr 
                325                 330                 335     


Asp Asn Phe Asp Leu Ser Lys Ile Tyr Ile Thr Ala Pro Tyr Tyr Glu 
            340                 345                 350         


Lys Ile Ser Asn Tyr Leu Cys Gly Ser Trp Asn Thr Ile Ala Asp Cys 
        355                 360                 365             


Leu Thr His Tyr Tyr Glu Gln Gln Ile Ala Gly Lys Gly Ala Arg Lys 
    370                 375                 380                 


Asp Gln Lys Val Lys Ala Ala Val Lys Ala Asp Lys Trp Lys Ser Leu 
385                 390                 395                 400 


Ser Glu Ile Glu Gln Leu Leu Lys Glu Tyr Ala Arg Ala Glu Glu Val 
                405                 410                 415     


Lys Arg Lys Pro Glu Glu Tyr Ile Ala Glu Ile Glu Asn Ile Val Ser 
            420                 425                 430         


Leu Lys Glu Val His Leu Leu Glu Tyr His Pro Glu Val Asn Leu Ile 
        435                 440                 445             


Glu Asn Glu Lys Tyr Ala Thr Glu Ile Lys Asp Val Leu Asp Asn Tyr 
    450                 455                 460                 


Met Glu Leu Phe His Trp Met Lys Trp Phe Tyr Ile Glu Glu Ala Val 
465                 470                 475                 480 


Glu Lys Glu Val Asn Phe Tyr Gly Glu Leu Asp Asp Leu Tyr Glu Glu 
                485                 490                 495     


Ile Arg Asp Ile Val Pro Leu Tyr Asn Lys Val Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Asp Thr Lys Ile Lys Leu Asn Phe Gly Thr Pro 
        515                 520                 525             


Thr Leu Ala Asn Gly Trp Ser Lys Ser Lys Glu Tyr Asp Tyr Asn Ala 
    530                 535                 540                 


Ile Leu Leu Gln Lys Asp Gly Lys Tyr Tyr Met Gly Ile Phe Asn Pro 
545                 550                 555                 560 


Val Gln Lys Pro Glu Lys Glu Ile Ile Glu Gly His Ser His Pro Leu 
                565                 570                 575     


Glu Gly Asn Glu Tyr Lys Lys Met Val Tyr Tyr Tyr Leu Pro Ser Ala 
            580                 585                 590         


Asn Lys Met Leu Pro Lys Val Leu Leu Ser Lys Lys Gly Met Glu Ile 
        595                 600                 605             


Tyr Gln Pro Ser Glu Tyr Ile Ile Asn Gly Tyr Lys Glu Arg Arg His 
    610                 615                 620                 


Ile Lys Ser Glu Glu Lys Phe Asp Leu Gln Phe Cys His Asp Leu Ile 
625                 630                 635                 640 


Asp Tyr Phe Lys Ser Gly Ile Glu Arg Asn Pro Asp Trp Lys Val Phe 
                645                 650                 655     


Gly Phe His Phe Ser Asp Thr Asp Thr Tyr Gln Asp Ile Ser Gly Phe 
            660                 665                 670         


Tyr Arg Glu Val Glu Asp Gln Gly Tyr Lys Ile Asp Trp Thr Tyr Ile 
        675                 680                 685             


Lys Glu Ala Asp Ile Asp Arg Leu Asn Glu Glu Gly Lys Leu Tyr Leu 
    690                 695                 700                 


Phe Gln Ile Tyr Asn Lys Asp Phe Ser Glu Lys Ser Thr Gly Arg Glu 
705                 710                 715                 720 


Asn Leu His Thr Met Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn Ile 
                725                 730                 735     


Arg Glu Gln Val Leu Lys Leu Asn Gly Glu Ala Glu Ile Phe Phe Arg 
            740                 745                 750         


Lys Ser Ser Val Lys Lys Pro Ile Ile His Lys Lys Gly Thr Met Leu 
        755                 760                 765             


Val Asn Arg Thr Tyr Met Glu Glu Met His Gly Glu Ser Val Lys Lys 
    770                 775                 780                 


Asn Ile Pro Glu Lys Glu Tyr Gln Glu Ile Tyr Asn Tyr Met Asn His 
785                 790                 795                 800 


Arg Trp Lys Gly Glu Leu Ser Ala Glu Ala Lys Glu Tyr Leu Lys Lys 
                805                 810                 815     


Ala Val Cys His Glu Thr Lys Lys Asp Ile Val Lys Asp Tyr Arg Tyr 
            820                 825                 830         


Ser Val Asp Lys Phe Phe Ile His Leu Pro Ile Thr Ile Asn Tyr Arg 
        835                 840                 845             


Ala Ser Gly Lys Glu Ala Leu Asn Ser Val Ala Gln Arg Tyr Ile Ala 
    850                 855                 860                 


His Gln Asn Asp Met His Val Ile Gly Ile Asp Arg Gly Glu Arg Asn 
865                 870                 875                 880 


Leu Ile Tyr Val Ser Val Ile Asn Met Gln Gly Glu Ile Ile Glu Gln 
                885                 890                 895     


Lys Ser Phe Asn Val Val Asn Lys Tyr Asn Tyr Lys Glu Lys Leu Lys 
            900                 905                 910         


Glu Arg Glu Gln Asn Arg Asp Glu Ala Arg Lys Asn Trp Lys Glu Ile 
        915                 920                 925             


Gly Gln Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ser Gly Val Ile His 
    930                 935                 940                 


Glu Ile Ala Lys Met Met Ile Lys Tyr His Ala Ile Val Ala Met Glu 
945                 950                 955                 960 


Asp Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Arg Gln 
                965                 970                 975     


Val Tyr Gln Lys Phe Glu Asn Met Leu Ile Gln Lys Leu Asn Tyr Leu 
            980                 985                 990         


Val Phe Lys Asp Arg Ser Ala Asp  Glu Asp Gly Gly Val  Leu Arg Gly 
        995                 1000                 1005             


Tyr Gln  Leu Ala Tyr Ile Pro  Asp Ser Val Lys Lys  Leu Gly Arg 
    1010                 1015                 1020             


Gln Cys  Gly Met Ile Phe Tyr  Val Pro Ala Ala Phe  Thr Ser Lys 
    1025                 1030                 1035             


Ile Asp  Pro Ala Thr Gly Phe  Val Asp Ile Phe Asn  His Lys Ala 
    1040                 1045                 1050             


Tyr Thr  Thr Asp Gln Ala Lys  Arg Glu Phe Ile Leu  Ser Phe Asp 
    1055                 1060                 1065             


Glu Ile  Cys Tyr Asp Val Glu  Arg Gln Leu Phe Arg  Phe Thr Phe 
    1070                 1075                 1080             


Asp Tyr  Ala Asn Phe Ala Thr  His Asn Val Thr Leu  Ala Arg Asn 
    1085                 1090                 1095             


Asn Trp  Thr Ile Tyr Thr Asn  Gly Thr Arg Thr Gln  Lys Glu Phe 
    1100                 1105                 1110             


Val Asn  Arg Arg Val Arg Asp  Lys Lys Glu Val Phe  Asp Pro Thr 
    1115                 1120                 1125             


Glu Lys  Met Leu Lys Leu Leu  Glu Leu Glu Gly Val  Glu Tyr Gln 
    1130                 1135                 1140             


Ser Gly  Ala Asn Leu Leu Pro  Lys Leu Glu Lys Ile  Ser Asp Pro 
    1145                 1150                 1155             


His Leu  Phe His Glu Leu Gln  Arg Ile Val Arg Phe  Thr Val Gln 
    1160                 1165                 1170             


Leu Arg  Asn Ser Lys Asn Glu  Glu Asn Asp Val Asp  Tyr Asp His 
    1175                 1180                 1185             


Val Ile  Ser Pro Val Leu Asn  Glu Glu Gly Lys Phe  Phe Asp Ser 
    1190                 1195                 1200             


Ser Lys  Tyr Glu Asn Lys Glu  Glu Lys Lys Glu Ser  Leu Leu Pro 
    1205                 1210                 1215             


Val Asp  Ala Asp Ala Asn Gly  Ala Tyr Cys Ile Ala  Leu Lys Gly 
    1220                 1225                 1230             


Leu Tyr  Ile Met Gln Ala Ile  Gln Lys Asn Trp Ser  Glu Glu Lys 
    1235                 1240                 1245             


Ala Leu  Ser Pro Asp Val Leu  Arg Leu Asn Asn Asn  Asp Trp Phe 
    1250                 1255                 1260             


Asp Tyr  Ile Gln Asn Lys Arg  Tyr Arg 
    1265                 1270         


<210> 630
<211> 767
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 630
Met Ala Gln Ala Ser Ser Thr Pro Ala Val Ser Pro Arg Pro Arg Pro 
1               5                   10                  15      


Arg Tyr Arg Glu Glu Arg Thr Leu Val Arg Lys Leu Leu Pro Arg Pro 
            20                  25                  30          


Gly Gln Ser Lys Gln Glu Phe Arg Glu Asn Val Lys Lys Leu Arg Lys 
        35                  40                  45              


Ala Phe Leu Gln Phe Asn Ala Asp Val Ser Gly Val Cys Gln Trp Ala 
    50                  55                  60                  


Ile Gln Phe Arg Pro Arg Tyr Gly Lys Pro Ala Glu Pro Thr Glu Thr 
65                  70                  75                  80  


Phe Trp Lys Phe Phe Leu Glu Pro Glu Thr Ser Leu Pro Pro Asn Asp 
                85                  90                  95      


Ser Arg Ser Pro Glu Phe Arg Arg Leu Gln Ala Phe Glu Ala Ala Ala 
            100                 105                 110         


Gly Ile Asn Gly Ala Ala Ala Leu Asp Asp Pro Ala Phe Thr Asn Glu 
        115                 120                 125             


Leu Arg Asp Ser Ile Leu Ala Val Ala Ser Arg Pro Lys Thr Lys Glu 
    130                 135                 140                 


Ala Gln Arg Leu Phe Ser Arg Leu Lys Asp Tyr Gln Pro Ala His Arg 
145                 150                 155                 160 


Met Ile Leu Ala Lys Val Ala Ala Glu Trp Ile Glu Ser Arg Tyr Arg 
                165                 170                 175     


Arg Ala His Gln Asn Trp Glu Arg Asn Tyr Glu Glu Trp Lys Lys Glu 
            180                 185                 190         


Lys Gln Glu Trp Glu Gln Asn His Pro Glu Leu Thr Pro Glu Ile Arg 
        195                 200                 205             


Glu Ala Phe Asn Gln Ile Phe Gln Gln Leu Glu Val Lys Glu Lys Arg 
    210                 215                 220                 


Val Arg Ile Cys Pro Ala Ala Arg Leu Leu Gln Asn Lys Asp Asn Cys 
225                 230                 235                 240 


Gln Tyr Ala Gly Lys Asn Lys His Ser Val Leu Cys Asn Gln Phe Asn 
                245                 250                 255     


Glu Phe Lys Lys Asn His Leu Gln Gly Lys Ala Ile Lys Phe Phe Tyr 
            260                 265                 270         


Lys Asp Ala Glu Lys Tyr Leu Arg Cys Gly Leu Gln Ser Leu Lys Pro 
        275                 280                 285             


Asn Val Gln Gly Pro Phe Arg Glu Asp Trp Asn Lys Tyr Leu Arg Tyr 
    290                 295                 300                 


Met Asn Leu Lys Glu Glu Thr Leu Arg Gly Lys Asn Gly Gly Arg Leu 
305                 310                 315                 320 


Pro His Cys Lys Asn Leu Gly Gln Glu Cys Glu Phe Asn Pro His Thr 
                325                 330                 335     


Ala Leu Cys Lys Gln Tyr Gln Gln Gln Leu Ser Ser Arg Pro Asp Leu 
            340                 345                 350         


Val Gln His Asp Glu Leu Tyr Arg Lys Trp Arg Arg Glu Tyr Trp Arg 
        355                 360                 365             


Glu Pro Arg Lys Pro Val Phe Arg Tyr Pro Ser Val Lys Arg His Ser 
    370                 375                 380                 


Ile Ala Lys Ile Phe Gly Glu Asn Tyr Phe Gln Ala Asp Phe Lys Asn 
385                 390                 395                 400 


Ser Val Val Gly Leu Arg Leu Asp Ser Met Pro Ala Gly Gln Tyr Leu 
                405                 410                 415     


Glu Phe Ala Phe Ala Pro Trp Pro Arg Asn Tyr Arg Pro Gln Pro Gly 
            420                 425                 430         


Glu Thr Glu Ile Ser Ser Val His Leu His Phe Val Gly Thr Arg Pro 
        435                 440                 445             


Arg Ile Gly Phe Arg Phe Arg Val Pro His Lys Arg Ser Arg Phe Asp 
    450                 455                 460                 


Cys Thr Gln Glu Glu Leu Asp Glu Leu Arg Ser Arg Thr Phe Pro Arg 
465                 470                 475                 480 


Lys Ala Gln Asp Gln Lys Phe Leu Glu Ala Ala Arg Lys Arg Leu Leu 
                485                 490                 495     


Glu Thr Phe Pro Gly Asn Ala Glu Gln Glu Leu Arg Leu Leu Ala Val 
            500                 505                 510         


Asp Leu Gly Thr Asp Ser Ala Arg Ala Ala Phe Phe Ile Gly Lys Thr 
        515                 520                 525             


Phe Gln Gln Ala Phe Pro Leu Lys Ile Val Lys Ile Glu Lys Leu Tyr 
    530                 535                 540                 


Glu Gln Trp Pro Asn Gln Lys Gln Ala Gly Asp Arg Arg Asp Ala Ser 
545                 550                 555                 560 


Ser Lys Gln Pro Arg Pro Gly Leu Ser Arg Asp His Val Gly Arg His 
                565                 570                 575     


Leu Gln Lys Met Arg Ala Gln Ala Ser Glu Ile Ala Gln Lys Arg Gln 
            580                 585                 590         


Glu Leu Thr Gly Thr Pro Ala Pro Glu Thr Thr Thr Asp Gln Ala Ala 
        595                 600                 605             


Lys Lys Ala Thr Leu Gln Pro Phe Asp Leu Arg Gly Leu Thr Val His 
    610                 615                 620                 


Thr Ala Arg Met Ile Arg Asp Trp Ala Arg Leu Asn Ala Arg Gln Ile 
625                 630                 635                 640 


Ile Gln Leu Ala Glu Glu Asn Gln Val Asp Leu Ile Val Leu Glu Ser 
                645                 650                 655     


Leu Arg Gly Phe Arg Pro Pro Gly Tyr Glu Asn Leu Asp Gln Glu Lys 
            660                 665                 670         


Lys Arg Arg Val Ala Phe Phe Ala His Gly Arg Ile Arg Arg Lys Val 
        675                 680                 685             


Thr Glu Lys Ala Val Glu Arg Gly Met Arg Val Val Thr Val Pro Tyr 
    690                 695                 700                 


Leu Ala Ser Ser Lys Val Cys Ala Glu Cys Arg Lys Lys Gln Lys Asp 
705                 710                 715                 720 


Asn Lys Gln Trp Glu Lys Asn Lys Lys Arg Gly Leu Phe Lys Cys Glu 
                725                 730                 735     


Gly Cys Gly Ser Gln Ala Gln Val Asp Glu Asn Ala Ala Arg Val Leu 
            740                 745                 750         


Gly Arg Val Phe Trp Gly Glu Ile Glu Leu Pro Thr Ala Ile Pro 
        755                 760                 765         


<210> 631
<211> 1147
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 631
Met Ala Val Lys Ser Ile Lys Val Lys Leu Arg Leu Ser Glu Cys Pro 
1               5                   10                  15      


Asp Ile Leu Ala Gly Met Trp Gln Leu His Arg Ala Thr Asn Ala Gly 
            20                  25                  30          


Val Arg Tyr Tyr Thr Glu Trp Val Ser Leu Met Arg Gln Glu Ile Leu 
        35                  40                  45              


Tyr Ser Arg Gly Pro Asp Gly Gly Gln Gln Cys Tyr Met Thr Ala Glu 
    50                  55                  60                  


Asp Cys Gln Arg Glu Leu Leu Arg Arg Leu Arg Asn Arg Gln Leu His 
65                  70                  75                  80  


Asn Gly Arg Gln Asp Gln Pro Gly Thr Asp Ala Asp Leu Leu Ala Ile 
                85                  90                  95      


Ser Arg Arg Leu Tyr Glu Ile Leu Val Leu Gln Ser Ile Gly Lys Arg 
            100                 105                 110         


Gly Asp Ala Gln Gln Ile Ala Ser Ser Phe Leu Ser Pro Leu Val Asp 
        115                 120                 125             


Pro Asn Ser Lys Gly Gly Arg Gly Glu Ala Lys Ser Gly Arg Lys Pro 
    130                 135                 140                 


Ala Trp Gln Lys Met Arg Asp Gln Gly Asp Pro Arg Trp Val Ala Ala 
145                 150                 155                 160 


Arg Glu Lys Tyr Glu Gln Arg Lys Ala Val Asp Pro Ser Lys Glu Ile 
                165                 170                 175     


Leu Asn Ser Leu Asp Ala Leu Gly Leu Arg Pro Leu Phe Ala Val Phe 
            180                 185                 190         


Thr Glu Thr Tyr Arg Ser Gly Val Asp Trp Lys Pro Leu Gly Lys Ser 
        195                 200                 205             


Gln Gly Val Arg Thr Trp Asp Arg Asp Met Phe Gln Gln Ala Leu Glu 
    210                 215                 220                 


Arg Leu Met Ser Trp Glu Ser Trp Asn Arg Arg Val Gly Glu Glu Tyr 
225                 230                 235                 240 


Ala Arg Leu Phe Gln Gln Lys Met Lys Phe Glu Gln Glu His Phe Ala 
                245                 250                 255     


Glu Gln Ser His Leu Val Lys Leu Ala Arg Ala Leu Glu Ala Asp Met 
            260                 265                 270         


Arg Ala Ala Ser Gln Gly Phe Glu Ala Lys Arg Gly Thr Ala His Gln 
        275                 280                 285             


Ile Thr Arg Arg Ala Leu Arg Gly Ala Asp Arg Val Phe Glu Ile Trp 
    290                 295                 300                 


Lys Ser Ile Pro Glu Glu Ala Leu Phe Ser Gln Tyr Asp Glu Val Ile 
305                 310                 315                 320 


Arg Gln Val Gln Ala Glu Lys Arg Arg Asp Phe Gly Ser His Asp Leu 
                325                 330                 335     


Phe Ala Lys Leu Ala Glu Pro Lys Tyr Gln Pro Leu Trp Arg Ala Asp 
            340                 345                 350         


Glu Thr Phe Leu Thr Arg Tyr Ala Leu Tyr Asn Gly Val Leu Arg Asp 
        355                 360                 365             


Leu Glu Lys Ala Arg Gln Phe Ala Thr Phe Thr Leu Pro Asp Ala Cys 
    370                 375                 380                 


Val Asn Pro Ile Trp Thr Arg Phe Glu Ser Ser Gln Gly Ser Asn Leu 
385                 390                 395                 400 


His Lys Tyr Glu Phe Leu Phe Asp His Leu Gly Pro Gly Arg His Ala 
                405                 410                 415     


Val Arg Phe Gln Arg Leu Leu Val Val Glu Ser Glu Gly Ala Lys Glu 
            420                 425                 430         


Arg Asp Ser Val Val Val Pro Val Ala Pro Ser Gly Gln Leu Asp Lys 
        435                 440                 445             


Leu Val Leu Arg Glu Glu Glu Lys Ser Ser Val Ala Leu His Leu His 
    450                 455                 460                 


Asp Thr Ala Arg Pro Asp Gly Phe Met Ala Glu Trp Ala Gly Ala Lys 
465                 470                 475                 480 


Leu Gln Tyr Glu Arg Ser Thr Leu Ala Arg Lys Ala Arg Arg Asp Lys 
                485                 490                 495     


Gln Gly Met Arg Ser Trp Arg Arg Gln Pro Ser Met Leu Met Ser Ala 
            500                 505                 510         


Ala Gln Met Leu Glu Asp Ala Lys Gln Ala Gly Asp Val Tyr Leu Asn 
        515                 520                 525             


Ile Ser Val Arg Val Lys Ser Pro Ser Glu Val Arg Gly Gln Arg Arg 
    530                 535                 540                 


Pro Pro Tyr Ala Ala Leu Phe Arg Ile Asp Asp Lys Gln Arg Arg Val 
545                 550                 555                 560 


Thr Val Asn Tyr Asn Lys Leu Ser Ala Tyr Leu Glu Glu His Pro Asp 
                565                 570                 575     


Lys Gln Ile Pro Gly Ala Pro Gly Leu Leu Ser Gly Leu Arg Val Met 
            580                 585                 590         


Ser Val Asp Leu Gly Leu Arg Thr Ser Ala Ser Ile Ser Val Phe Arg 
        595                 600                 605             


Val Ala Lys Lys Glu Glu Val Glu Ala Leu Gly Asp Gly Arg Pro Pro 
    610                 615                 620                 


His Tyr Tyr Pro Ile His Gly Thr Asp Asp Leu Val Ala Val His Glu 
625                 630                 635                 640 


Arg Ser His Leu Ile Gln Met Pro Gly Glu Thr Glu Thr Lys Gln Leu 
                645                 650                 655     


Arg Lys Leu Arg Glu Glu Arg Gln Ala Val Leu Arg Pro Leu Phe Ala 
            660                 665                 670         


Gln Leu Ala Leu Leu Arg Leu Leu Val Arg Cys Gly Ala Ala Asp Glu 
        675                 680                 685             


Arg Ile Arg Thr Arg Ser Trp Gln Arg Leu Thr Lys Gln Gly Arg Glu 
    690                 695                 700                 


Phe Thr Lys Arg Leu Thr Pro Ser Trp Arg Glu Ala Leu Glu Leu Glu 
705                 710                 715                 720 


Leu Thr Arg Leu Glu Ala Tyr Cys Gly Arg Val Pro Asp Asp Glu Trp 
                725                 730                 735     


Ser Arg Ile Val Asp Arg Thr Val Ile Ala Leu Trp Arg Arg Met Gly 
            740                 745                 750         


Lys Gln Val Arg Asp Trp Arg Lys Gln Val Lys Ser Gly Ala Lys Val 
        755                 760                 765             


Lys Val Lys Gly Tyr Gln Leu Asp Val Val Gly Gly Asn Ser Leu Ala 
    770                 775                 780                 


Gln Ile Asp Tyr Leu Glu Gln Gln Tyr Lys Phe Leu Arg Arg Trp Ser 
785                 790                 795                 800 


Phe Phe Ala Arg Ala Ser Gly Leu Val Val Arg Ala Asp Arg Glu Ser 
                805                 810                 815     


His Phe Ala Val Ala Leu Arg Gln His Ile Glu Asn Ala Lys Arg Asp 
            820                 825                 830         


Arg Leu Lys Lys Leu Ala Asp Arg Ile Leu Met Glu Ala Leu Gly Tyr 
        835                 840                 845             


Val Tyr Glu Ala Ser Gly Pro Arg Glu Gly Gln Trp Thr Ala Gln His 
    850                 855                 860                 


Pro Pro Cys Gln Leu Ile Ile Leu Glu Glu Leu Ser Ala Tyr Arg Phe 
865                 870                 875                 880 


Ser Asp Asp Arg Pro Pro Ser Glu Asn Ser Lys Leu Met Ala Trp Gly 
                885                 890                 895     


His Arg Gly Ile Leu Glu Glu Leu Val Asn Gln Ala Gln Val His Asp 
            900                 905                 910         


Val Leu Val Gly Thr Val Tyr Ala Ala Phe Ser Ser Arg Phe Asp Ala 
        915                 920                 925             


Arg Thr Gly Ala Pro Gly Val Arg Cys Arg Arg Val Pro Ala Arg Phe 
    930                 935                 940                 


Val Gly Ala Thr Val Asp Asp Ser Leu Pro Leu Trp Leu Thr Glu Phe 
945                 950                 955                 960 


Leu Asp Lys His Arg Leu Asp Lys Asn Leu Leu Arg Pro Asp Asp Val 
                965                 970                 975     


Ile Pro Thr Gly Glu Gly Glu Phe Leu Val Ser Pro Cys Gly Glu Glu 
            980                 985                 990         


Ala Ala Arg Val Arg Gln Val His  Ala Asp Ile Asn Ala  Ala Gln Asn 
        995                 1000                 1005             


Leu Gln  Arg Arg Leu Trp Gln  Asn Phe Asp Ile Thr  Glu Leu Arg 
    1010                 1015                 1020             


Leu Arg  Cys Asp Val Lys Met  Gly Gly Glu Gly Thr  Val Leu Val 
    1025                 1030                 1035             


Pro Arg  Val Asn Asn Ala Arg  Ala Lys Gln Leu Phe  Gly Lys Lys 
    1040                 1045                 1050             


Val Leu  Val Ser Gln Asp Gly  Val Thr Phe Phe Glu  Arg Ser Gln 
    1055                 1060                 1065             


Thr Gly  Gly Lys Pro His Ser  Glu Lys Gln Thr Asp  Leu Thr Asp 
    1070                 1075                 1080             


Lys Glu  Leu Glu Leu Ile Ala  Glu Ala Asp Glu Ala  Arg Ala Lys 
    1085                 1090                 1095             


Ser Val  Val Leu Phe Arg Asp  Pro Ser Gly His Ile  Gly Lys Gly 
    1100                 1105                 1110             


His Trp  Ile Arg Gln Arg Glu  Phe Trp Ser Leu Val  Lys Gln Arg 
    1115                 1120                 1125             


Ile Glu  Ser His Thr Ala Glu  Arg Ile Arg Val Arg  Gly Val Gly 
    1130                 1135                 1140             


Ser Ser  Leu Asp 
    1145         


<210> 632
<211> 687
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"


<220>
<221> MOD_RES
<222> (156)..(527)
<223> Any amino acid

<400> 632
Met Ser Asn Pro Asn Ile Pro Asn Ile Ser Pro Asn Ile Thr Leu Thr 
1               5                   10                  15      


Arg Asp Asp Val Val Asn Leu Leu Met Ser Ser Ile Ala Met Glu Glu 
            20                  25                  30          


Leu Gly Leu Ala His Ile Ile Asn Ala Glu Gly Glu Lys Ile Gln Phe 
        35                  40                  45              


Ala Leu Gly Thr Leu Gln Gly Ala Ser Gly Pro Pro Ala Thr Leu Gln 
    50                  55                  60                  


Gln Val Leu Glu Val Asn Gln Ser Thr Gln Ala Met Leu Asp Thr Ile 
65                  70                  75                  80  


Phe Arg Gln Glu Met Met Leu Asp Ser Lys Leu Lys Thr Ala Thr Asn 
                85                  90                  95      


Ile Pro Thr Leu Arg Gly Pro Thr Gly Pro Val Gly Pro Thr Gly Ala 
            100                 105                 110         


Pro Gly Gly Val Ile Ser Ile Asn Gly Gln Thr Gly Val Val Thr Leu 
        115                 120                 125             


Asp Ala Ser Asn Gly Val Met Pro Phe Met Arg Glu Gln Ser Thr Ser 
    130                 135                 140                 


Ser Leu Asp Asp Tyr Lys Asp Pro Gly Ile Tyr Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly 
        515                 520                 525             


Ala Thr Gly Ala Thr Gly Ala Thr Gly Ala Thr Gly Pro Gln Glu Pro 
    530                 535                 540                 


Arg Ala Leu Arg Glu Pro Arg Ala Pro Gln Ala Arg Arg Glu Pro Arg 
545                 550                 555                 560 


Gly Leu Leu Glu Pro Gln Val Leu Arg Gly Pro Gln Glu Pro Arg Ala 
                565                 570                 575     


Leu Arg Glu Pro Arg Ala Pro Arg Ala Leu Arg Glu Pro Arg Ala Leu 
            580                 585                 590         


Arg Ala Leu Arg Ala Leu Gln Glu Leu Arg Ala Pro Arg Ala Leu Arg 
        595                 600                 605             


Gly Leu Gln Glu Pro Arg Val Leu Gln Gly Pro Arg Glu Arg Gln Val 
    610                 615                 620                 


Arg Pro Glu Pro Arg Val Leu Gln Gly Pro Arg Glu Arg Gln Val Arg 
625                 630                 635                 640 


Gln Gly Leu Gln Gly Leu Leu Glu Pro Arg Ala Lys Arg Glu Arg Gln 
                645                 650                 655     


Val Arg Pro Glu Pro Arg Glu Pro Gln Glu Arg Gln Ala Pro Leu Val 
            660                 665                 670         


Gln Gln Ala Leu Leu Glu Pro Gln Ala Leu Leu Gly Gln Ala Leu 
        675                 680                 685         


<210> 633
<211> 1212
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 633
Met Ile Lys Lys Ser Asn Phe Trp Gln Phe Thr Gly Leu Tyr Glu Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Trp Glu Thr Leu Asn 
            20                  25                  30          


Ile Leu Glu Lys Asp Trp Val Ser Gln Lys Asp Lys Glu Val Glu Glu 
        35                  40                  45              


Asn Tyr Asn Lys Ile Lys Val Phe Phe Asp Ser Leu His Arg Glu Phe 
    50                  55                  60                  


Val Lys Gln Ser Leu Glu Asn Trp Tyr Leu Glu Leu Leu Glu Asn Phe 
65                  70                  75                  80  


Tyr Asn Ser Tyr Ile Glu Leu Asn Lys Asn Ile Glu Asn Lys Lys Asn 
                85                  90                  95      


Lys Ser Leu Gln Lys Leu Phe Glu Lys Ser Ser Lys Glu Leu Lys Lys 
            100                 105                 110         


Glu Leu Val Ser Phe Phe Glu Trp Lys Trp Asn Asp Trp Lys Gln Lys 
        115                 120                 125             


Tyr Ser Phe Leu Lys Lys Trp Trp Ile Asp Val Leu Asn Glu Lys Glu 
    130                 135                 140                 


Val Leu Asp Leu Met Trp Glu Phe Tyr Pro Lys Glu Lys Glu Leu Phe 
145                 150                 155                 160 


Lys Lys Phe Asp Lys Phe Phe Thr Tyr Phe Ser Asn Phe Lys Glu Ser 
                165                 170                 175     


Arg Lys Asn Phe Tyr Ala Asp Asp Trp Arg Ala Trp Ala Ile Ala Thr 
            180                 185                 190         


Arg Val Ile Asp Glu Asn Leu Ile Thr Phe Ile Lys Asn Ile Glu Asp 
        195                 200                 205             


Phe Lys Lys Phe Lys Asn Asn Phe Ser Asp Phe Ile Glu Asn Gly Phe 
    210                 215                 220                 


Ser Asp Trp Lys Ile Lys Ile Asn Trp Phe Thr Leu Glu Glu Lys Gln 
225                 230                 235                 240 


Val Phe Asp Leu Asp Phe Tyr Asn Asn Cys Leu Leu Gln Asp Trp Ile 
                245                 250                 255     


Asp Asn Tyr Asn Lys Ile Leu Trp Trp Phe Ser Glu Glu Asn Trp Asn 
            260                 265                 270         


Lys Ile Gln Trp Ile Asn Glu Lys Ile Asn Leu Phe Lys Gln Asn Gln 
        275                 280                 285             


Asn Lys Thr Asn Ser Lys Asp Val Lys Phe Pro Arg Phe Lys Leu Leu 
    290                 295                 300                 


Tyr Lys Gln Ile Leu Ser Glu Lys Glu Lys Leu Ile Phe Val Asp Glu 
305                 310                 315                 320 


Ile Glu Asn Asp Glu Lys Leu Ile Asn Phe Ile Lys Glu Ser Lys Asn 
                325                 330                 335     


Asn Asn Leu Ile Lys Val Glu Lys Ala Ile Glu Ile Thr Glu Asn Phe 
            340                 345                 350         


Ile Lys Asn Asn Glu Thr Phe Glu Leu Asp Lys Ile Tyr Leu Ser Lys 
        355                 360                 365             


Ile Ser Ile Asn Thr Ile Ser Asn Lys Phe Phe Ser Ser Trp Asp Tyr 
    370                 375                 380                 


Ile Leu Lys Glu Gly Phe Asp Lys Trp Glu Ile Lys Glu Phe Ile Ser 
385                 390                 395                 400 


Phe Glu Asp Leu Lys Asn Ala Phe Gly Lys Ile Lys Tyr Glu Asn Leu 
                405                 410                 415     


Glu Asp Ile Phe Lys Ser Asn Tyr Ile Thr Asp Tyr Ile Ala Ile Asn 
            420                 425                 430         


Trp Glu Asp Leu Tyr Lys Asn Phe Leu Asn Ile Phe Leu Tyr Glu Phe 
        435                 440                 445             


Lys Gln Asn Ile Asn Glu Ile Asn Phe Tyr Asn Ser Glu Leu Glu Lys 
    450                 455                 460                 


Leu Phe Leu Glu Lys Phe Glu Lys Thr Glu Thr Gln Val Gln Ile Ile 
465                 470                 475                 480 


Lys Asn Tyr Phe Asp Ser Val Leu Ser Leu Tyr Lys Met Thr Lys Tyr 
                485                 490                 495     


Phe Ala Leu Glu Lys Gly Lys Lys Lys Ile Glu Asp Leu Glu Thr Asp 
            500                 505                 510         


Asn Asn Phe Tyr Asn Asp Phe Phe Val Tyr Tyr Glu Asp Phe Glu Ile 
        515                 520                 525             


Trp Lys Asp Tyr Asn Leu Val Arg Asn Phe Ile Thr Lys Lys Gln Val 
    530                 535                 540                 


Lys Thr Asp Lys Phe Lys Leu Asn Phe Glu Asn Ser Gln Phe Leu Thr 
545                 550                 555                 560 


Gly Trp Asp Lys Asp Lys Glu Lys Glu Arg Leu Trp Ile Ile Leu Lys 
                565                 570                 575     


Lys Asp Glu Lys Tyr Tyr Leu Trp Ile Leu Lys Asn Asn Lys Ile Phe 
            580                 585                 590         


Asn Ser Tyr Asn Tyr Glu Ser Trp Asp Phe Tyr Glu Lys Met Ser Tyr 
        595                 600                 605             


Lys Gln Leu Asn Asn Val Tyr Arg Gln Leu Pro Arg Phe Ala Phe Ser 
    610                 615                 620                 


Lys Ala Lys Arg Glu Val Tyr Trp Ile Thr Pro Glu Leu Glu Gln Ile 
625                 630                 635                 640 


Lys Glu Glu Phe Asp Ile Phe Gln Lys Asn Lys Glu Lys Trp Glu Lys 
                645                 650                 655     


Phe Asp Ile Glu Lys Leu Lys Lys Leu Ile Asn Cys Tyr Lys Lys Trp 
            660                 665                 670         


Phe Ile Lys Thr Tyr Glu Asn Glu Phe Asp Leu Glu Lys Ile Lys Asn 
        675                 680                 685             


Thr Asp Tyr Leu Asp Leu Ala Thr Phe Tyr Asp Glu Ile Glu Gln Lys 
    690                 695                 700                 


Thr Tyr Lys Ile Asp Phe Asn Lys Ile Ser Glu Asn Phe Ile Asn Ala 
705                 710                 715                 720 


Lys Val Asn Ser Trp Glu Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp 
                725                 730                 735     


Phe Ser Glu Thr Lys Lys Ala Trp Ser Lys Glu Asn Ile His Thr Lys 
            740                 745                 750         


Tyr Phe Lys Leu Leu Phe Asp Glu Lys Asn Leu Glu Lys Leu Val Ile 
        755                 760                 765             


Lys Leu Ser Trp Trp Ala Glu Met Phe Phe Arg Glu Lys Thr Glu Lys 
    770                 775                 780                 


Leu Lys Thr Lys Leu Asp Lys Ser Trp Lys Glu Val Leu Glu His Arg 
785                 790                 795                 800 


Arg Tyr Ser Lys Asp Lys Ile Met Leu His Leu Ser Ile Thr Leu Asn 
                805                 810                 815     


Ala Asn Lys Trp Asp Ser Phe Trp Phe Asn Lys Met Val Asn Glu Tyr 
            820                 825                 830         


Leu Asn Lys Asn Glu Asp Ile Lys Ile Ile Trp Ile Asp Arg Gly Glu 
        835                 840                 845             


Lys His Leu Ala Tyr Tyr Ser Val Ile Asp Lys Asn Trp Lys Ile Glu 
    850                 855                 860                 


Glu Ile Asp Thr Leu Asn Ile Ile Lys Ser Ser Asp Trp Lys Ile Thr 
865                 870                 875                 880 


Asn Tyr Leu Glu Lys Leu Glu Lys Ile Glu Ser Ser Arg Lys Asp Ser 
                885                 890                 895     


Arg Val Ser Trp Trp Glu Ile Glu Asn Ile Lys Glu Leu Lys Asn Gly 
            900                 905                 910         


Tyr Ile Ser Gln Val Val Asn Lys Leu Ala Glu Leu Ile Ile Lys Tyr 
        915                 920                 925             


Asn Ala Ile Ile Val Phe Glu Asp Leu Asn Ile Trp Phe Lys Arg Trp 
    930                 935                 940                 


Arg Gln Lys Ile Glu Lys Gln Ile Tyr Gln Lys Leu Glu Leu Ala Leu 
945                 950                 955                 960 


Ala Lys Lys Leu Asn Tyr Leu Thr Gln Lys Asp Lys Asn Asp Asn Glu 
                965                 970                 975     


Val Leu Trp Asn Leu Lys Ala Leu Gln Leu Val Pro Lys Val Asn Asp 
            980                 985                 990         


Tyr Gln Asp Ile Ala Asn Tyr Lys  Gln Ser Gly Ile Met  Phe Tyr Thr 
        995                 1000                 1005             


Arg Ala  Asn Tyr Thr Ser Thr  Thr Cys Pro Cys Cys  Trp Phe Arg 
    1010                 1015                 1020             


Lys Asn  Ile Tyr Ile Ser Asn  Ser Asp Thr Lys Glu  Lys Gln Lys 
    1025                 1030                 1035             


Lys Asp  Phe Glu Lys Ile Asp  Ile Lys Phe Asp Gly  Glu Lys Phe 
    1040                 1045                 1050             


Ile Phe  Ser Tyr Glu Ile Ile  Gln Asp Lys Lys Ala  Lys Gln Lys 
    1055                 1060                 1065             


Ser Asn  Lys Thr Asn Phe Ser  Val Asn Ser Asn Phe  Ser Arg Phe 
    1070                 1075                 1080             


Lys Tyr  Asn Ser Lys Lys Met  Leu Val Glu Glu Val  Asn Leu Asn 
    1085                 1090                 1095             


Leu Glu  Leu Gln Asn Leu Phe  Lys Asp Ile Asp Leu  Lys Trp Asp 
    1100                 1105                 1110             


Ile Asn  Lys Gln Ile Leu Glu  Lys Asp Ser Tyr Phe  Tyr Lys Ser 
    1115                 1120                 1125             


Leu Thr  Tyr Tyr Phe Asn Leu  Ile Leu Gln Leu Arg  Asn Ser Asp 
    1130                 1135                 1140             


Ser Lys  Asn Asp Ile Asp Tyr  Ile Thr Cys Pro Ser  Cys Asn Tyr 
    1145                 1150                 1155             


His Ser  Lys Asp Trp Phe Gln  Gly Leu Glu Tyr Asn  Ala Asp Ala 
    1160                 1165                 1170             


Asn Trp  Ala Tyr Asn Ile Ala  Arg Lys Trp Ile Ile  Met Leu Asp 
    1175                 1180                 1185             


Arg Ile  Glu Lys Asn Phe Glu  Lys Pro Asp Leu Tyr  Val Ser Asp 
    1190                 1195                 1200             


Ile Asp  Trp Asp Asn Phe Thr  Gln Lys 
    1205                 1210         


<210> 634
<211> 1212
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 634
Met Ile Lys Lys Ser Asn Phe Trp Gln Phe Thr Gly Leu Tyr Glu Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Trp Glu Thr Leu Asn 
            20                  25                  30          


Ile Leu Glu Lys Asp Trp Val Ser Gln Lys Asp Lys Glu Val Glu Glu 
        35                  40                  45              


Asn Tyr Asn Lys Ile Lys Val Phe Phe Asp Ser Leu His Arg Glu Phe 
    50                  55                  60                  


Val Lys Gln Ser Leu Glu Asn Trp Tyr Leu Glu Leu Leu Glu Asn Phe 
65                  70                  75                  80  


Tyr Asn Ser Tyr Ile Glu Leu Asn Lys Asn Ile Glu Asn Lys Lys Asn 
                85                  90                  95      


Lys Ser Leu Gln Lys Leu Phe Glu Lys Ser Ser Lys Glu Leu Lys Lys 
            100                 105                 110         


Glu Leu Val Ser Phe Phe Glu Trp Lys Trp Asn Asp Trp Lys Gln Lys 
        115                 120                 125             


Tyr Ser Phe Leu Lys Lys Trp Trp Ile Asp Val Leu Asn Glu Lys Glu 
    130                 135                 140                 


Val Leu Asp Leu Met Trp Glu Phe Tyr Pro Lys Glu Lys Glu Leu Phe 
145                 150                 155                 160 


Lys Lys Phe Asp Lys Phe Phe Thr Tyr Phe Ser Asn Phe Lys Glu Ser 
                165                 170                 175     


Arg Lys Asn Phe Tyr Ala Asp Asp Trp Arg Ala Trp Ala Ile Ala Thr 
            180                 185                 190         


Arg Val Ile Asp Glu Asn Leu Ile Thr Phe Ile Lys Asn Ile Glu Asp 
        195                 200                 205             


Phe Lys Lys Phe Lys Asn Asn Phe Ser Asp Phe Ile Glu Asn Gly Phe 
    210                 215                 220                 


Ser Asp Trp Lys Ile Lys Ile Asn Trp Phe Thr Leu Glu Glu Lys Gln 
225                 230                 235                 240 


Val Phe Asp Leu Asp Phe Tyr Asn Asn Cys Leu Leu Gln Asp Trp Ile 
                245                 250                 255     


Asp Asn Tyr Asn Lys Ile Leu Trp Trp Phe Ser Glu Glu Asn Trp Asn 
            260                 265                 270         


Lys Ile Gln Trp Ile Asn Glu Lys Ile Asn Leu Phe Lys Gln Asn Gln 
        275                 280                 285             


Asn Lys Thr Asn Ser Lys Asp Val Lys Phe Pro Arg Phe Lys Leu Leu 
    290                 295                 300                 


Tyr Lys Gln Ile Leu Ser Glu Lys Glu Lys Leu Ile Phe Val Asp Glu 
305                 310                 315                 320 


Ile Glu Asn Asp Glu Lys Leu Ile Asn Phe Ile Lys Glu Ser Lys Asn 
                325                 330                 335     


Asn Asn Leu Ile Lys Val Glu Lys Ala Ile Glu Ile Thr Glu Asn Phe 
            340                 345                 350         


Ile Lys Asn Asn Glu Thr Phe Glu Leu Asp Lys Ile Tyr Leu Ser Lys 
        355                 360                 365             


Ile Ser Ile Asn Thr Ile Ser Asn Lys Phe Phe Ser Ser Trp Asp Tyr 
    370                 375                 380                 


Ile Leu Lys Glu Gly Phe Asp Lys Trp Glu Ile Lys Glu Phe Ile Ser 
385                 390                 395                 400 


Phe Glu Asp Leu Lys Asn Ala Phe Gly Lys Ile Lys Tyr Glu Asn Leu 
                405                 410                 415     


Glu Asp Ile Phe Lys Ser Asn Tyr Ile Thr Asp Tyr Ile Ala Ile Asn 
            420                 425                 430         


Trp Glu Asp Leu Tyr Lys Asn Phe Leu Asn Ile Phe Leu Tyr Glu Phe 
        435                 440                 445             


Lys Gln Asn Ile Asn Glu Ile Asn Phe Tyr Asn Ser Glu Leu Glu Lys 
    450                 455                 460                 


Leu Phe Leu Glu Lys Phe Glu Lys Thr Glu Thr Gln Val Gln Ile Ile 
465                 470                 475                 480 


Lys Asn Tyr Phe Asp Ser Val Leu Ser Leu Tyr Lys Met Thr Lys Tyr 
                485                 490                 495     


Phe Ala Leu Glu Lys Gly Lys Lys Lys Ile Glu Asp Leu Glu Thr Asp 
            500                 505                 510         


Asn Asn Phe Tyr Asn Asp Phe Phe Val Tyr Tyr Glu Asp Phe Glu Ile 
        515                 520                 525             


Trp Lys Asp Tyr Asn Leu Val Arg Asn Phe Ile Thr Lys Lys Gln Val 
    530                 535                 540                 


Lys Thr Asp Lys Phe Lys Leu Asn Phe Glu Asn Ser Gln Phe Leu Thr 
545                 550                 555                 560 


Gly Trp Asp Lys Asp Lys Glu Lys Glu Arg Leu Trp Ile Ile Leu Lys 
                565                 570                 575     


Lys Asp Glu Lys Tyr Tyr Leu Trp Ile Leu Lys Asn Asn Lys Ile Phe 
            580                 585                 590         


Asn Ser Tyr Asn Tyr Glu Ser Trp Asp Phe Tyr Glu Lys Met Ser Tyr 
        595                 600                 605             


Lys Gln Leu Asn Asn Val Tyr Arg Gln Leu Pro Arg Phe Ala Phe Ser 
    610                 615                 620                 


Lys Ala Lys Arg Glu Val Tyr Trp Ile Thr Pro Glu Leu Glu Gln Ile 
625                 630                 635                 640 


Lys Glu Glu Phe Asp Ile Phe Gln Lys Asn Lys Glu Lys Trp Glu Lys 
                645                 650                 655     


Phe Asp Ile Glu Lys Leu Lys Lys Leu Ile Asn Cys Tyr Lys Lys Trp 
            660                 665                 670         


Phe Ile Lys Thr Tyr Glu Asn Glu Phe Asp Leu Glu Lys Ile Lys Asn 
        675                 680                 685             


Thr Asp Tyr Leu Asp Leu Ala Thr Phe Tyr Asp Glu Ile Glu Gln Lys 
    690                 695                 700                 


Thr Tyr Lys Ile Asp Phe Asn Lys Ile Ser Glu Asn Phe Ile Asn Ala 
705                 710                 715                 720 


Lys Val Asn Ser Trp Glu Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp 
                725                 730                 735     


Phe Ser Glu Thr Lys Lys Ala Trp Ser Lys Glu Asn Ile His Thr Lys 
            740                 745                 750         


Tyr Phe Lys Leu Leu Phe Asp Glu Lys Asn Leu Glu Lys Leu Val Ile 
        755                 760                 765             


Lys Leu Ser Trp Trp Ala Glu Met Phe Phe Arg Glu Lys Thr Glu Lys 
    770                 775                 780                 


Leu Lys Thr Lys Leu Asp Lys Ser Trp Lys Glu Val Leu Glu His Arg 
785                 790                 795                 800 


Arg Tyr Ser Lys Asp Lys Ile Met Leu His Leu Ser Ile Thr Leu Asn 
                805                 810                 815     


Ala Asn Lys Trp Asp Ser Phe Trp Phe Asn Lys Met Val Asn Glu Tyr 
            820                 825                 830         


Leu Asn Lys Asn Glu Asp Ile Lys Ile Ile Trp Ile Asp Arg Gly Glu 
        835                 840                 845             


Lys His Leu Ala Tyr Tyr Ser Val Ile Asp Lys Asn Trp Lys Ile Glu 
    850                 855                 860                 


Glu Ile Asp Thr Leu Asn Ile Ile Lys Ser Ser Asp Trp Lys Ile Thr 
865                 870                 875                 880 


Asn Tyr Leu Glu Lys Leu Glu Lys Ile Glu Ser Ser Arg Lys Asp Ser 
                885                 890                 895     


Arg Val Ser Trp Trp Glu Ile Glu Asn Ile Lys Glu Leu Lys Asn Gly 
            900                 905                 910         


Tyr Ile Ser Gln Val Val Asn Lys Leu Ala Glu Leu Ile Ile Lys Tyr 
        915                 920                 925             


Asn Ala Ile Ile Val Phe Glu Asp Leu Asn Ile Trp Phe Lys Arg Trp 
    930                 935                 940                 


Arg Gln Lys Ile Glu Lys Gln Ile Tyr Gln Lys Leu Glu Leu Ala Leu 
945                 950                 955                 960 


Ala Lys Lys Leu Asn Tyr Leu Thr Gln Lys Asp Lys Asn Asp Asn Glu 
                965                 970                 975     


Val Leu Trp Asn Leu Lys Ala Leu Gln Leu Val Pro Lys Val Asn Asp 
            980                 985                 990         


Tyr Gln Asp Ile Ala Asn Tyr Lys  Gln Ser Gly Ile Met  Phe Tyr Thr 
        995                 1000                 1005             


Arg Ala  Asn Tyr Thr Ser Thr  Thr Cys Pro Cys Cys  Trp Phe Arg 
    1010                 1015                 1020             


Lys Asn  Ile Tyr Ile Ser Asn  Ser Asp Thr Lys Glu  Lys Gln Lys 
    1025                 1030                 1035             


Lys Asp  Phe Glu Lys Ile Asp  Ile Lys Phe Asp Gly  Glu Lys Phe 
    1040                 1045                 1050             


Ile Phe  Ser Tyr Glu Ile Ile  Gln Asp Lys Lys Ala  Lys Gln Lys 
    1055                 1060                 1065             


Ser Asn  Lys Thr Asn Phe Ser  Val Asn Ser Asn Phe  Ser Arg Phe 
    1070                 1075                 1080             


Lys Tyr  Asn Ser Lys Lys Met  Leu Val Glu Glu Val  Asn Leu Asn 
    1085                 1090                 1095             


Leu Glu  Leu Gln Asn Leu Phe  Lys Asp Ile Asp Leu  Lys Trp Asp 
    1100                 1105                 1110             


Ile Asn  Lys Gln Ile Leu Glu  Lys Asp Ser Tyr Phe  Tyr Lys Ser 
    1115                 1120                 1125             


Leu Thr  Tyr Tyr Phe Asn Leu  Ile Leu Gln Leu Arg  Asn Ser Asp 
    1130                 1135                 1140             


Ser Lys  Asn Asp Ile Asp Tyr  Ile Thr Cys Pro Ser  Cys Asn Tyr 
    1145                 1150                 1155             


His Ser  Lys Asp Trp Phe Gln  Gly Leu Glu Tyr Asn  Ala Asp Ala 
    1160                 1165                 1170             


Asn Trp  Ala Tyr Asn Ile Ala  Arg Lys Trp Ile Ile  Met Leu Asp 
    1175                 1180                 1185             


Arg Ile  Glu Lys Asn Phe Glu  Lys Pro Asp Leu Tyr  Val Ser Asp 
    1190                 1195                 1200             


Ile Asp  Trp Asp Asn Phe Thr  Gln Lys 
    1205                 1210         


<210> 635
<211> 1108
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"

<400> 635
Met Ala Thr Arg Ser Phe Ile Leu Lys Ile Glu Pro Asn Glu Glu Val 
1               5                   10                  15      


Lys Lys Gly Leu Trp Lys Thr His Glu Val Leu Asn His Gly Ile Ala 
            20                  25                  30          


Tyr Tyr Met Asn Ile Leu Lys Leu Ile Arg Gln Glu Ala Ile Tyr Glu 
        35                  40                  45              


His His Glu Gln Asp Pro Lys Asn Pro Lys Lys Val Ser Lys Ala Glu 
    50                  55                  60                  


Ile Gln Ala Glu Leu Trp Asp Phe Val Leu Lys Met Gln Lys Cys Asn 
65                  70                  75                  80  


Ser Phe Thr His Glu Val Asp Lys Asp Val Val Phe Asn Ile Leu Arg 
                85                  90                  95      


Glu Leu Tyr Glu Glu Leu Val Pro Ser Ser Val Glu Lys Lys Gly Glu 
            100                 105                 110         


Ala Asn Gln Leu Ser Asn Lys Phe Leu Tyr Pro Leu Val Asp Pro Asn 
        115                 120                 125             


Ser Gln Ser Gly Lys Gly Thr Ala Ser Ser Gly Arg Lys Pro Arg Trp 
    130                 135                 140                 


Tyr Asn Leu Lys Ile Ala Gly Asp Pro Ser Trp Glu Glu Glu Lys Lys 
145                 150                 155                 160 


Lys Trp Glu Glu Asp Lys Lys Lys Asp Pro Leu Ala Lys Ile Leu Gly 
                165                 170                 175     


Lys Leu Ala Glu Tyr Gly Leu Ile Pro Leu Phe Ile Pro Phe Thr Asp 
            180                 185                 190         


Ser Asn Glu Pro Ile Val Lys Glu Ile Lys Trp Met Glu Lys Ser Arg 
        195                 200                 205             


Asn Gln Ser Val Arg Arg Leu Asp Lys Asp Met Phe Ile Gln Ala Leu 
    210                 215                 220                 


Glu Arg Phe Leu Ser Trp Glu Ser Trp Asn Leu Lys Val Lys Glu Glu 
225                 230                 235                 240 


Tyr Glu Lys Val Glu Lys Glu His Lys Thr Leu Glu Glu Arg Ile Lys 
                245                 250                 255     


Glu Asp Ile Gln Ala Phe Lys Ser Leu Glu Gln Tyr Glu Lys Glu Arg 
            260                 265                 270         


Gln Glu Gln Leu Leu Arg Asp Thr Leu Asn Thr Asn Glu Tyr Arg Leu 
        275                 280                 285             


Ser Lys Arg Gly Leu Arg Gly Trp Arg Glu Ile Ile Gln Lys Trp Leu 
    290                 295                 300                 


Lys Met Asp Glu Asn Glu Pro Ser Glu Lys Tyr Leu Glu Val Phe Lys 
305                 310                 315                 320 


Asp Tyr Gln Arg Lys His Pro Arg Glu Ala Gly Asp Tyr Ser Val Tyr 
                325                 330                 335     


Glu Phe Leu Ser Lys Lys Glu Asn His Phe Ile Trp Arg Asn His Pro 
            340                 345                 350         


Glu Tyr Pro Tyr Leu Tyr Ala Thr Phe Cys Glu Ile Asp Lys Lys Lys 
        355                 360                 365             


Lys Asp Ala Lys Gln Gln Ala Thr Phe Thr Leu Ala Asp Pro Ile Asn 
    370                 375                 380                 


His Pro Leu Trp Val Arg Phe Glu Glu Arg Ser Gly Ser Asn Leu Asn 
385                 390                 395                 400 


Lys Tyr Arg Ile Leu Thr Glu Gln Leu His Thr Glu Lys Leu Lys Lys 
                405                 410                 415     


Lys Leu Thr Val Gln Leu Asp Arg Leu Ile Tyr Pro Thr Glu Ser Gly 
            420                 425                 430         


Gly Trp Glu Glu Lys Gly Lys Val Asp Ile Val Leu Leu Pro Ser Arg 
        435                 440                 445             


Gln Phe Tyr Asn Gln Ile Phe Leu Asp Ile Glu Glu Lys Gly Lys His 
    450                 455                 460                 


Ala Phe Thr Tyr Lys Asp Glu Ser Ile Lys Phe Pro Leu Lys Gly Thr 
465                 470                 475                 480 


Leu Gly Gly Ala Arg Val Gln Phe Asp Arg Asp His Leu Arg Arg Tyr 
                485                 490                 495     


Pro His Lys Val Glu Ser Gly Asn Val Gly Arg Ile Tyr Phe Asn Met 
            500                 505                 510         


Thr Val Asn Ile Glu Pro Thr Glu Ser Pro Val Ser Lys Ser Leu Lys 
        515                 520                 525             


Ile His Arg Asp Asp Phe Pro Lys Phe Val Asn Phe Lys Pro Lys Glu 
    530                 535                 540                 


Leu Thr Glu Trp Ile Lys Asp Ser Lys Gly Lys Lys Leu Lys Ser Gly 
545                 550                 555                 560 


Ile Glu Ser Leu Glu Ile Gly Leu Arg Val Met Ser Ile Asp Leu Gly 
                565                 570                 575     


Gln Arg Gln Ala Ala Ala Ala Ser Ile Phe Glu Val Val Asp Gln Lys 
            580                 585                 590         


Pro Asp Ile Glu Gly Lys Leu Phe Phe Pro Ile Lys Gly Thr Glu Leu 
        595                 600                 605             


Tyr Ala Val His Arg Ala Ser Phe Asn Ile Lys Leu Pro Gly Glu Thr 
    610                 615                 620                 


Leu Val Lys Ser Arg Glu Val Leu Arg Lys Ala Arg Glu Asp Asn Leu 
625                 630                 635                 640 


Lys Leu Met Asn Gln Lys Leu Asn Phe Leu Arg Asn Val Leu His Phe 
                645                 650                 655     


Gln Gln Phe Glu Asp Ile Thr Glu Arg Glu Lys Arg Val Thr Lys Trp 
            660                 665                 670         


Ile Ser Arg Gln Glu Asn Ser Asp Val Pro Leu Val Tyr Gln Asp Glu 
        675                 680                 685             


Leu Ile Gln Ile Arg Glu Leu Met Tyr Lys Pro Tyr Lys Asp Trp Val 
    690                 695                 700                 


Ala Phe Leu Lys Gln Leu His Lys Arg Leu Glu Val Glu Ile Gly Lys 
705                 710                 715                 720 


Glu Val Lys His Trp Arg Lys Ser Leu Ser Asp Gly Arg Lys Gly Leu 
                725                 730                 735     


Tyr Gly Ile Ser Leu Lys Asn Ile Asp Glu Ile Asp Arg Thr Arg Lys 
            740                 745                 750         


Phe Leu Leu Arg Trp Ser Leu Arg Pro Thr Glu Pro Gly Glu Val Arg 
        755                 760                 765             


Arg Leu Glu Pro Gly Gln Arg Phe Ala Ile Asp Gln Leu Asn His Leu 
    770                 775                 780                 


Asn Ala Leu Lys Glu Asp Arg Leu Lys Lys Met Ala Asn Thr Ile Ile 
785                 790                 795                 800 


Met His Ala Leu Gly Tyr Cys Tyr Asp Val Arg Lys Lys Lys Trp Gln 
                805                 810                 815     


Ala Lys Asn Pro Ala Cys Gln Ile Ile Leu Phe Glu Asp Leu Ser Asn 
            820                 825                 830         


Tyr Asn Pro Tyr Glu Glu Arg Ser Arg Phe Glu Asn Ser Lys Leu Met 
        835                 840                 845             


Lys Trp Ser Arg Arg Glu Ile Pro Arg Gln Val Ala Leu Gln Gly Glu 
    850                 855                 860                 


Ile Tyr Gly Leu Gln Val Gly Glu Val Gly Ala Gln Phe Ser Ser Arg 
865                 870                 875                 880 


Phe His Ala Lys Thr Gly Ser Pro Gly Ile Arg Cys Ser Val Val Thr 
                885                 890                 895     


Lys Glu Lys Leu Gln Asp Asn Arg Phe Phe Lys Asn Leu Gln Arg Glu 
            900                 905                 910         


Gly Arg Leu Thr Leu Asp Lys Ile Ala Val Leu Lys Glu Gly Asp Leu 
        915                 920                 925             


Tyr Pro Asp Lys Gly Gly Glu Lys Phe Ile Ser Leu Ser Lys Asp Arg 
    930                 935                 940                 


Lys Leu Val Thr Thr His Ala Asp Ile Asn Ala Ala Gln Asn Leu Gln 
945                 950                 955                 960 


Lys Arg Phe Trp Thr Arg Thr His Gly Phe Tyr Lys Val Tyr Cys Lys 
                965                 970                 975     


Ala Tyr Gln Val Asp Gly Gln Thr Val Tyr Ile Pro Glu Ser Lys Asp 
            980                 985                 990         


Gln Lys Gln Lys Ile Ile Glu Glu  Phe Gly Glu Gly Tyr  Phe Ile Leu 
        995                 1000                 1005             


Lys Asp  Gly Val Tyr Glu Trp  Gly Asn Ala Gly Lys  Leu Lys Ile 
    1010                 1015                 1020             


Lys Lys  Gly Ser Ser Lys Gln  Ser Ser Ser Glu Leu  Val Asp Ser 
    1025                 1030                 1035             


Asp Ile  Leu Lys Asp Ser Phe  Asp Leu Ala Ser Glu  Leu Lys Gly 
    1040                 1045                 1050             


Glu Lys  Leu Met Leu Tyr Arg  Asp Pro Ser Gly Asn  Val Phe Pro 
    1055                 1060                 1065             


Ser Asp  Lys Trp Met Ala Ala  Gly Val Phe Phe Gly  Lys Leu Glu 
    1070                 1075                 1080             


Arg Ile  Leu Ile Ser Lys Leu  Thr Asn Gln Tyr Ser  Ile Ser Thr 
    1085                 1090                 1095             


Ile Glu  Asp Asp Ser Ser Lys  Gln Ser Met 
    1100                 1105             


<210> 636
<211> 688
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12 sequence"


<220>
<221> MOD_RES
<222> (276)..(564)
<223> Any amino acid

<400> 636
Met Ala Glu Ser Met Tyr Asn Gln Gln Asn Ile Asn Gln Lys Ser Thr 
1               5                   10                  15      


Glu Thr Pro Thr Glu Glu Asp Ala Leu Gly Ile Lys Asn Pro Leu Leu 
            20                  25                  30          


Thr Pro Thr Thr Leu Gly Gln Asn Phe Leu Ser Leu Gln Ser Ile Ser 
        35                  40                  45              


Pro Leu Gly Ser Arg Ser Ile Asn Leu Ile Asn Trp Ser Leu Ile Ser 
    50                  55                  60                  


Pro Asn Gln Thr Leu Leu Gln Asn Phe Gln Asp Asn Glu Asn Trp Gln 
65                  70                  75                  80  


Asp Ser Ser Ile Ser Glu Phe Arg Pro Phe Ser Lys Asn Ser Leu Thr 
                85                  90                  95      


Glu Asn Ser Pro Ile Ile Glu Pro Gln Ser Asp Lys Thr Leu Pro Ser 
            100                 105                 110         


Ser Val Pro Ile Gln Leu Ser Ser Glu Leu Pro Ile Gln Gln Pro Pro 
        115                 120                 125             


Glu Thr Ser Phe Ile Asp Ser Glu Ser Pro Ile Pro Gln Pro Pro Glu 
    130                 135                 140                 


Thr Pro Ser Ser Asp Ser Glu Ser Pro Ile Gly Gln Thr Glu Asn Ile 
145                 150                 155                 160 


Phe Pro Phe Gln Ile Asp Gln Lys Thr Arg Arg Asn Ser Val Ile Gln 
                165                 170                 175     


Asn Ser Lys Ser Ser Ile Ser His Phe Phe Gln Lys Lys Ser Glu Phe 
            180                 185                 190         


Pro Arg Glu Lys Ile Ser Gln Glu Asn Val Asn Lys Leu Thr Lys Lys 
        195                 200                 205             


Ser Ala Glu Asn Gln Asp Ile Ser Thr Thr Glu Glu Ser Val Ile Asn 
    210                 215                 220                 


Ser Ile Glu Thr Asn Asp Leu Gln Thr Ile Asn Pro Thr Asp Ile Pro 
225                 230                 235                 240 


Asn Pro Glu Ile Pro Val Ser Thr Leu Gln Lys Gln Pro Asp Ser Thr 
                245                 250                 255     


Ile Asp Asn Ile Pro Gln Thr Glu Ser Val Ser Thr Ile Asn Pro Thr 
            260                 265                 270         


Asp Ile Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Ser Lys Asn Asn Arg Ile Pro Gln Leu Ile Thr Phe 
                565                 570                 575     


Leu Lys Leu Asn Gln Tyr Gln Gln Leu Ile Leu Gln Ile Phe Leu Thr 
            580                 585                 590         


Gln Lys Phe Ser Phe Gln Leu Ser Lys Asn Asn Arg Ile Pro Pro Leu 
        595                 600                 605             


Ile Thr Phe Leu Lys Leu Asn Gln Tyr Gln Gln Leu Ile Pro Arg Val 
    610                 615                 620                 


Leu Leu His Gln Lys Phe Leu Phe Gln Leu Phe Lys Asn Asn Arg Ile 
625                 630                 635                 640 


Pro Pro Leu Ile Thr Phe Pro Lys Leu Asn Gln Tyr Gln Gln Leu Ile 
                645                 650                 655     


Pro Arg Ile Phe Leu Thr Gln Lys Phe Pro Phe Gln Ile Ser Arg Asn 
            660                 665                 670         


Asn Arg Ile Pro Gln Leu Ile Thr Phe Pro Lys Leu Asn Gln Tyr Gln 
        675                 680                 685             


<210> 637
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 637
Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 638
<211> 986
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 638
Met Ala Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys 
1               5                   10                  15      


Met Lys Leu Gly Ala Ile Ser Gly Phe Gly Lys Asp Gly Asn Glu Val 
            20                  25                  30          


Asn Asp Ile Asn Lys Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile 
        35                  40                  45              


Glu Asn Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly 
    50                  55                  60                  


Arg Phe Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met 
65                  70                  75                  80  


Phe Tyr Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu 
                85                  90                  95      


Arg Asn Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu 
            100                 105                 110         


Ile Lys Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu 
        115                 120                 125             


Leu Asn Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys 
    130                 135                 140                 


Leu Arg Phe Met Val Gly Glu Asp Glu Val Ala His Leu Arg Arg Cys 
145                 150                 155                 160 


Lys Ala Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe 
                165                 170                 175     


Tyr Tyr Arg Leu Ser Asp Asn Gly Gly Val Thr Glu Lys Gly Val Ile 
            180                 185                 190         


Phe Ile Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu 
        195                 200                 205             


Lys Gln Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu 
    210                 215                 220                 


Thr Leu Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg 
225                 230                 235                 240 


Leu Lys Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu 
                245                 250                 255     


Asn Glu Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr Leu Ser Val 
            260                 265                 270         


Asp Cys Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp Asp Leu Arg 
        275                 280                 285             


Ser Arg Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe 
    290                 295                 300                 


Ile Ser Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr Thr Tyr Val 
305                 310                 315                 320 


Gly Asn Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr 
                325                 330                 335     


Asp Lys Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser 
            340                 345                 350         


Val Asn Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu 
        355                 360                 365             


Ile Lys Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg 
    370                 375                 380                 


Pro His Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn 
385                 390                 395                 400 


Ile Gly Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Ile Val Asn Gly 
                405                 410                 415     


Lys Gly Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu 
            420                 425                 430         


Leu Pro Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys 
        435                 440                 445             


Arg Phe Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Gly Val Glu 
    450                 455                 460                 


Lys Lys Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala 
465                 470                 475                 480 


Arg His Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu 
                485                 490                 495     


Val Lys Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly 
            500                 505                 510         


Arg Val Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp 
        515                 520                 525             


Met Val Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly 
    530                 535                 540                 


Val Asn Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp 
545                 550                 555                 560 


Ile Leu Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His 
                565                 570                 575     


Arg His Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu 
            580                 585                 590         


Arg Asp Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu 
        595                 600                 605             


Asp Val Ala Lys Lys Ile Ala Lys Asn Lys Leu Asn Thr Pro Cys His 
    610                 615                 620                 


Ile Leu Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys 
625                 630                 635                 640 


Asp Val Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Asp Ser Ile 
                645                 650                 655     


Lys Asn Cys Leu Glu Gln Ser Lys Leu Asn Ile Tyr Ile Arg Asn Ala 
            660                 665                 670         


Arg Asn Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu Ile Leu Met 
        675                 680                 685             


Tyr Tyr Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu 
    690                 695                 700                 


Lys Arg Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Ala 
705                 710                 715                 720 


Glu Arg Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val 
                725                 730                 735     


Ser Glu Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Met Arg Lys 
            740                 745                 750         


Arg Tyr His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln 
        755                 760                 765             


Val Gln Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys 
    770                 775                 780                 


Ala Leu Ser Glu Gly Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu 
785                 790                 795                 800 


Asn Gly Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn 
                805                 810                 815     


Ile Lys Leu Thr Ala Thr Gly Ile Lys Ile Lys Asn Tyr Gly Lys Val 
            820                 825                 830         


Cys Arg Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile Lys Ala Phe 
        835                 840                 845             


His Lys Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu 
    850                 855                 860                 


Lys Glu Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu 
865                 870                 875                 880 


Cys Arg Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu 
                885                 890                 895     


Asp Gly Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile Lys Pro Tyr 
            900                 905                 910         


Asn Asp Lys Tyr Asn Val Phe Asn Gly Asp Asp Leu Thr Phe Phe Ile 
        915                 920                 925             


Asn Ala Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val 
    930                 935                 940                 


Lys Tyr Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser 
945                 950                 955                 960 


Phe Ala Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met 
                965                 970                 975     


Arg Lys Lys Thr Gly Leu Arg Ile Asp Ile 
            980                 985     


<210> 639
<211> 1009
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 639
Met Lys Lys Lys Ile Ser Leu Lys Glu Gln Arg Asn Thr Lys Lys Ala 
1               5                   10                  15      


Glu Asn Lys Leu Lys Tyr Gln Lys Ala Gln Ala Glu Arg Ala Ala Ala 
            20                  25                  30          


Ala Gln Gln Thr Ala Ala Gly Ala Glu Ser Glu Glu Asn Pro Cys Phe 
        35                  40                  45              


Asp Val Val Lys Asp Thr Lys Arg Lys Ala Leu Asn Pro Leu His Val 
    50                  55                  60                  


Glu Ile Glu Ala Pro Ser Ala Lys Lys Ser Ser Val Lys Ala Asn Gly 
65                  70                  75                  80  


Leu Lys Ser Leu Leu Leu Thr Asp Gly Lys Thr Val Met Thr Ser Phe 
                85                  90                  95      


Gly Arg Gly Ser Glu Ala Asn Val Glu Lys Arg Phe Asp Glu Thr Gly 
            100                 105                 110         


Thr Lys Thr Phe Asp Arg Asp Pro Glu Leu Phe Ser Ala Lys Pro Leu 
        115                 120                 125             


Glu Thr Gly Tyr Arg Ile Gln Arg Phe Asn Ala Ser Pro Lys Asp Ala 
    130                 135                 140                 


Gly Leu Ala Tyr Arg Pro Ala Gly Val Arg Pro Asp Gln Ile Gly Ala 
145                 150                 155                 160 


Lys Ala Ala Leu Glu Lys Arg Tyr Phe Gly Lys Glu Thr Pro Gly Asp 
                165                 170                 175     


Asn Ile His Val Gln Ile Ala Tyr Gln Ile Gln Asp Ile Glu Lys Leu 
            180                 185                 190         


Leu Ala Val Tyr Ile Ser Asn Ile Ile Tyr Ala Val Asn Asn Val Thr 
        195                 200                 205             


Gly Val Ser Ala Met Lys Asp Ser Lys Gly Arg Pro Val Asp Leu Leu 
    210                 215                 220                 


Gly Asp Tyr Gly Ile Leu Gly Glu Glu Gly Leu Thr Lys Arg Leu Gln 
225                 230                 235                 240 


Arg Ile Pro Glu Gln Ala Asp Glu Glu Ala Lys Ala Leu Gln Ala Phe 
                245                 250                 255     


Leu Cys Ser Glu Arg Leu Ser Tyr Phe Gly Lys Glu Phe Cys Leu Val 
            260                 265                 270         


Arg Asn Ser Pro Lys Gln Pro Asp Lys Glu Glu Lys Arg Gln Tyr Lys 
        275                 280                 285             


Leu Met Arg Val Leu Cys Leu Leu Gly Glu Leu Arg Gln Phe Leu Val 
    290                 295                 300                 


His Gly Lys Lys Lys Glu Lys Glu Phe Ala Trp Leu Tyr Arg Leu Asp 
305                 310                 315                 320 


Arg Gln Leu Ser Gln Glu Tyr Arg Lys Leu Leu Gly Glu Phe Tyr Asp 
                325                 330                 335     


Ala Gln Val Asp Lys Val Asn Lys Ser Phe Leu Thr Asn Ser Thr Val 
            340                 345                 350         


Asn Leu Glu Val Leu Phe Arg Ala Leu Lys Thr Gly Thr Asp Pro Glu 
        355                 360                 365             


Arg Lys Thr Val Thr Gln Glu Tyr Tyr Gln Phe Thr Val Arg Lys Glu 
    370                 375                 380                 


Asp Gly Asn Leu Gly Phe Ser Leu Lys Thr Leu Arg Glu Ile Leu Leu 
385                 390                 395                 400 


Ser Ala Tyr Lys His Glu Val Arg Asp Lys Glu Tyr Asp Ser Ile Arg 
                405                 410                 415     


His Lys Leu Tyr Gln Leu Phe Ser Phe Ala Leu Tyr His Tyr Tyr Lys 
            420                 425                 430         


Thr Gly Val Gly Ala Glu Arg Arg Glu Ala Phe Val Ala Lys Leu Arg 
        435                 440                 445             


Ala Val Met Thr Ala Glu Ala Lys Gln Arg Ala Tyr Ala Asp Glu Ala 
    450                 455                 460                 


Ala Glu Ile Trp Asn Asp Glu Gly Ser Gly Ile Arg Ala Ala Phe Leu 
465                 470                 475                 480 


Glu Ile Leu Glu Ala Val Asp Phe Gly Ser Ala Val Lys Gly Ile Lys 
                485                 490                 495     


Ala Arg Ser Ser Val Ala Gly Asp Lys Arg Phe Ala Glu Trp Leu Glu 
            500                 505                 510         


Glu Val Arg Ile Arg Pro Glu Gly Val Ser Cys Phe Thr Lys Leu Met 
        515                 520                 525             


Tyr Leu Leu Thr Arg Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu Leu 
    530                 535                 540                 


Thr Gly Leu Ile Asn Lys Leu Glu Asn Ile Gln Ser Phe Leu Asp Val 
545                 550                 555                 560 


Met Gln Gln Glu His Ala Glu Thr Gly Leu Ser Asp Ala Phe Ser Phe 
                565                 570                 575     


Phe Glu Tyr Ser Gly Glu Ile Ala Ala Glu Leu Arg Met Thr Arg Ser 
            580                 585                 590         


Phe Ala Arg Met Ala Ala Ala Asp Pro Glu Ala Lys Arg Phe Met Val 
        595                 600                 605             


Val Asp Gly Ala Lys Leu Leu Gly Phe Asn Pro Lys Asp Thr Glu Ser 
    610                 615                 620                 


Glu Asp Glu Gly Ile Ile Arg Ala Ile Tyr Gly Asp Ala Cys Ala Glu 
625                 630                 635                 640 


Tyr Leu Gln Phe Ser Glu Glu Glu Lys Glu Ala Phe Tyr Val Gln Glu 
                645                 650                 655     


Gly Leu Tyr Gly Lys Glu Arg Glu Lys Phe Ser Pro Tyr Ala Tyr Phe 
            660                 665                 670         


His Thr Asp Thr Ser Leu Arg Asn Phe Ile Ala Lys Asn Val Val Glu 
        675                 680                 685             


Ser Ala Arg Phe Arg Tyr Val Ile Arg Tyr Val Ser Pro Glu Ile Ala 
    690                 695                 700                 


Arg Lys Tyr Ala Arg Gln Glu Ala Leu Val Arg Phe Ala Leu His Arg 
705                 710                 715                 720 


Val Pro Leu Leu Gln Leu Arg Arg Tyr Tyr Gln Ser Cys Cys Gly Pro 
                725                 730                 735     


Lys Lys Asp Pro Asp Ala Ala Glu Cys Val Asp Phe Leu Ala Gly Val 
            740                 745                 750         


Val Asn Arg Val Asp Phe Ala Asn Phe Thr Asp Val Arg Thr Gly Asp 
        755                 760                 765             


Ser Ser Lys Ser Glu Gln Glu Lys Lys Gln Lys Tyr Gln Ala Ile Val 
    770                 775                 780                 


Gly Leu Tyr Leu Thr Val Val Tyr Trp Ile Val Lys Asn Leu Val Asn 
785                 790                 795                 800 


Val Asn Ser Arg Tyr Val Met Ala Phe His Ile Leu Glu Arg Asp Thr 
                805                 810                 815     


Val Leu Leu Glu Gly Lys Arg Leu Phe Val Gly Gly Met Lys Ala Glu 
            820                 825                 830         


Asp Pro Phe Leu Leu Thr Asp Gly Tyr Val Ser Arg Gln Asp Ala Tyr 
        835                 840                 845             


Val Arg Lys Arg Ile Gly Glu Asn Lys Arg Ala Asn Arg His Gly Leu 
    850                 855                 860                 


Asn Cys Val Leu Glu Asn Arg Asn Ala Leu Gly Ser Asp Pro Ala Ser 
865                 870                 875                 880 


Thr Asp Ala Ala Ala Ser Leu Ile Trp Ser Tyr Arg Asn Ala Ala Ala 
                885                 890                 895     


His Leu Thr Ala Val Ala Ala Ala Gln Glu Tyr Val Ser Glu Leu Arg 
            900                 905                 910         


Glu Ile His Ser Tyr Phe Glu Val Tyr His Tyr Ala Met Gln Arg Tyr 
        915                 920                 925             


Leu Lys Ser Gly Ala Glu Phe Ala Glu Leu Val Ser Lys Asn Gly Pro 
    930                 935                 940                 


Ala Ser Gly Lys Ile Ala Ala Trp Ala Asn Ala Val Asp Arg Cys His 
945                 950                 955                 960 


Ser Phe Cys Lys Asp Trp Leu Trp Leu Leu Asn Val Pro Phe Ala Tyr 
                965                 970                 975     


Asn Pro Ala Arg Tyr Lys Asn Leu Ser Ile Ala Asn Leu Phe Asp Lys 
            980                 985                 990         


Asn Glu Ala Ala Pro Val Thr Glu  Asp Ala Ser Glu Gln  Lys Glu Asp 
        995                 1000                 1005             


Glu 
    


<210> 640
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 640
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 641
<211> 985
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 641
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210> 642
<211> 1082
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 642
Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile Ala Glu Tyr Gln 
1               5                   10                  15      


Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val Ile Arg Tyr Leu 
            20                  25                  30          


Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val Pro Lys Asn Gln 
        35                  40                  45              


Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser Leu Lys Val Leu 
    50                  55                  60                  


Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr His His Phe His 
65                  70                  75                  80  


Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu Leu Asp Asp Leu 
                85                  90                  95      


Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg Met Lys Thr Asp 
            100                 105                 110         


Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu Glu Leu Ala Gln 
        115                 120                 125             


Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu Lys Arg Glu Gly 
    130                 135                 140                 


Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr Asn Ala Ile Leu 
145                 150                 155                 160 


Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn Thr Ile Ser Lys 
                165                 170                 175     


Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr Glu Asn Gly Val 
            180                 185                 190         


Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly Leu Phe Leu Thr 
        195                 200                 205             


Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys Gly Phe Lys Ala 
    210                 215                 220                 


Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys Lys Asn Asn Ser 
225                 230                 235                 240 


Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr Leu Gly Phe Lys 
                245                 250                 255     


Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys Asp Thr Leu Leu 
            260                 265                 270         


Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp Glu Leu Tyr Gln 
        275                 280                 285             


Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu Asp Met Asn Glu 
    290                 295                 300                 


Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys Ala Thr Val Ile 
305                 310                 315                 320 


His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe Ala Tyr Phe Ala 
                325                 330                 335     


Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr Leu Arg Phe Gln 
            340                 345                 350         


Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu Lys Pro Ile Glu 
        355                 360                 365             


Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu Lys Ile Lys Ala 
    370                 375                 380                 


Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln Lys Tyr Phe Glu 
385                 390                 395                 400 


Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu Tyr Pro Asn Pro 
                405                 410                 415     


Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His Leu Asn Leu Asn 
            420                 425                 430         


Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala Gly Arg Leu Lys 
        435                 440                 445             


Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu Glu Tyr Lys Val 
    450                 455                 460                 


Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu Gln Asp Leu Gly 
465                 470                 475                 480 


Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser Leu Asn Glu Leu 
                485                 490                 495     


Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr Pro Glu Glu Ile 
            500                 505                 510         


Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr Asn Val Leu Thr 
        515                 520                 525             


Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln Ile Thr Lys Asn 
    530                 535                 540                 


Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu Asp Lys Leu Gln 
545                 550                 555                 560 


Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp Lys Leu Gln Thr 
                565                 570                 575     


Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys Gln Lys Arg Lys 
            580                 585                 590         


Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val Thr Trp Leu Ala 
        595                 600                 605             


Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg Gln Asn Trp Arg 
    610                 615                 620                 


Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala Phe Tyr Asp Ile 
625                 630                 635                 640 


Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val Trp Asp Phe Lys 
                645                 650                 655     


Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg Ser Phe Asp Lys 
            660                 665                 670         


Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn Asn Arg Lys Glu 
        675                 680                 685             


Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile Arg Ser Asn Lys 
    690                 695                 700                 


Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu Trp Asn Leu Phe 
705                 710                 715                 720 


His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu Gln Val Glu Lys 
                725                 730                 735     


Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val Phe Asp His Lys 
            740                 745                 750         


Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn Pro Glu Cys Phe 
        755                 760                 765             


Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp Tyr Gln Lys Phe 
    770                 775                 780                 


Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu Ser Gly Glu Gln 
785                 790                 795                 800 


Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly Ser Lys Ile Asn 
                805                 810                 815     


Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met Ala Ser Ile Ile 
            820                 825                 830         


Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His Leu Asp Leu Asn 
        835                 840                 845             


Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys Ala Glu Ile Glu 
    850                 855                 860                 


Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp Asn Ser Ala Asn 
865                 870                 875                 880 


Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val Pro Tyr Cys Ser 
                885                 890                 895     


Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu Leu Gly Lys Phe 
            900                 905                 910         


Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu Phe Glu Tyr Lys 
        915                 920                 925             


Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu Val Leu Glu Leu 
    930                 935                 940                 


Lys Ala Asn Ser Tyr Glu Val Ile Arg Arg Asp Tyr Leu Leu Lys Ser 
945                 950                 955                 960 


Ile Gln Glu Phe Glu Lys Tyr Met Ile Lys Lys Leu Pro Thr Leu Ile 
                965                 970                 975     


Asp Thr Asn Glu His Pro Asn Phe Asn Lys Tyr Leu Thr Thr Phe Leu 
            980                 985                 990         


Lys Ser Leu Glu Leu Val Ser Glu  Glu Asp Ala Lys Trp  Leu Ile Ser 
        995                 1000                 1005             


Lys Lys  Asp Phe Asp Thr Thr  Pro Ile Asp Glu Leu  Lys Lys Gln 
    1010                 1015                 1020             


Ser Lys  Ile Met Glu Lys Ala  Phe Leu Leu Val Met  Ile Arg Asn 
    1025                 1030                 1035             


Lys Phe  Ser His Asn Gln Leu  Pro Arg Lys Ile Tyr  Tyr Asp Glu 
    1040                 1045                 1050             


Ile Tyr  Lys Asn Val Pro Asn  Ala Val Ser Ile Asn  Phe Asn Glu 
    1055                 1060                 1065             


Leu Phe  Leu Glu Tyr Thr Asn  Gln Thr Ile Leu Glu  Phe Lys 
    1070                 1075                 1080         


<210> 643
<211> 708
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 643
Asn Arg Arg Asp Met Glu Ala Ser Pro Gly Arg Leu Ala Arg Tyr Ile 
1               5                   10                  15      


Val Leu Lys Thr Leu Tyr Glu Arg Ala Phe Pro Arg Trp Leu Glu Ala 
            20                  25                  30          


Arg Glu Ala Glu Thr Leu Asn Gly Trp Ile Gly Arg Ala Ala Asp Arg 
        35                  40                  45              


Ala Thr Val Ala Ala Arg His Ile Asn Lys Asp Glu Asn Ala Ala Ala 
    50                  55                  60                  


Arg Met Ala Gly Leu Val Arg Leu Ala Asp Gly Lys Gly Ile Ala Asp 
65                  70                  75                  80  


Phe Thr Asp Arg Leu Ala Ala Glu Thr Ala Ser Glu Tyr Arg Val Gln 
                85                  90                  95      


Arg Gly Tyr Asp Ser Asp Pro Ala Val Ala Arg Lys Gln Ala Lys His 
            100                 105                 110         


Ile Glu Asp Leu Arg Cys Asp Val Val Gly Gln Ala Phe Glu Ala Tyr 
        115                 120                 125             


Leu Ala Asp Val Ala Arg Lys Leu Ala Trp Thr Met Asn Asp Pro Pro 
    130                 135                 140                 


Gly Gly Pro Leu Pro Asp Glu Lys Lys Ala Ser Leu Glu Thr Ala Ala 
145                 150                 155                 160 


Pro Pro Ala Glu Asp Ala Gly Ala Glu Ala Glu Glu Asp Trp Leu Ala 
                165                 170                 175     


Arg Leu Tyr Phe Leu Leu His Met Leu Pro Val Glu Glu Val Gly Gly 
            180                 185                 190         


Leu Arg His Gln Leu Arg Lys Trp Ser Val Leu Glu Arg Glu Pro Asp 
        195                 200                 205             


Ser Val Leu Glu Arg Glu Pro Asp Ala Asp Val Glu Ala Ile Glu Arg 
    210                 215                 220                 


Ile Leu Gly Leu Tyr Leu Asp Met His Asp Ala Lys Phe Glu Gly Gly 
225                 230                 235                 240 


Asp Gly Val Ala Gly Ala Glu Ala Leu Thr Asp Leu Phe Thr Ser Pro 
                245                 250                 255     


Ala Gln Phe Arg Arg Val Cys Pro Glu Asp Gly Ala Gly Asn Gly Gly 
            260                 265                 270         


His Val Pro Trp Arg Gly Leu Arg Glu Met Leu Arg Phe Gly Gly Gly 
        275                 280                 285             


Glu Pro Arg Leu Met Trp Ala Phe Arg Lys Trp Pro Ile Gly Asp Gly 
    290                 295                 300                 


Met Val Asp Gly Leu Asn Ala Leu Glu Ala Thr Val Ala Glu Ala His 
305                 310                 315                 320 


Lys Gln Arg Glu Asp Leu His Ala Lys Trp Ala Gly Lys Lys Gly Phe 
                325                 330                 335     


Ser Arg Lys Asp Lys Asp Glu Tyr Arg Ala Ala Leu Glu Thr Val Val 
            340                 345                 350         


Val His Arg His Leu Ala Ala His Val Gln Leu Val Asn His Ala Arg 
        355                 360                 365             


Leu His Arg Leu Ala Met Ala Val Leu Ala Arg Leu Ala Asp Tyr Ala 
    370                 375                 380                 


Gly Leu Trp Glu Arg Asp Leu Tyr Phe Thr Thr Leu Ala Leu Ile Arg 
385                 390                 395                 400 


Leu Glu Asn Gly Lys Pro Glu Asp Val Phe Arg Ser Arg Glu Leu Glu 
                405                 410                 415     


Trp Leu Arg Glu Gly Arg Ile Val Asp Ala Leu Lys Glu Leu Lys Lys 
            420                 425                 430         


Asn Ala Asp Gly Ser Glu Pro Ala Val Gly Thr Ala Leu Gln Arg Leu 
        435                 440                 445             


Phe Gly Lys Gly Ile Leu Thr Gly Gly Gly Thr Val Ser Val Arg Arg 
    450                 455                 460                 


Asp Leu Leu His Phe Asn Met Leu Gln Arg Lys Ala Asn Glu Pro Phe 
465                 470                 475                 480 


Asn Leu Thr Thr Ala Val Asn Asp Thr Arg Lys Leu Met Ala Tyr Asp 
                485                 490                 495     


Arg Lys Leu Lys Asn Ala Val Ser Arg Ser Ile Ile Glu Leu Leu Ala 
            500                 505                 510         


Arg Glu Gly Leu Asp Leu Ala Trp Glu Met Lys Asp His Gln Leu Ala 
        515                 520                 525             


Gly Ala Val Leu Lys Thr Arg Gln Ala Val His Leu Gly Gly Ala Lys 
    530                 535                 540                 


Val Gly Gly Gly Pro Ile Thr Glu Asp Leu His Gly Pro Glu Phe Thr 
545                 550                 555                 560 


Ala Met Ala Ala Ala Leu Phe Gly Gly Glu Ala Arg Ala Ala Thr Asp 
                565                 570                 575     


Ala Ala Glu Ala Ala Thr Gly Arg Pro Asp Arg Arg Glu Arg Lys Ser 
            580                 585                 590         


Gly Gly Ala Ser Pro Arg Pro Ala Arg Pro Ala Lys Thr Leu Pro Ala 
        595                 600                 605             


Pro Thr Pro Arg Leu Leu Pro Ala Ala Gly Glu Arg Val Glu Gly Val 
    610                 615                 620                 


Leu Val Glu Glu Lys Thr Arg Lys Gly Gly Trp Lys Ala Ala Val Glu 
625                 630                 635                 640 


Ile Gly Gly Pro Arg Ile Val Gly Asp Ile Phe Asn Ser Gly Glu Val 
                645                 650                 655     


Pro Ser Asp Ala Glu Pro Gly Leu Glu Ala Glu Phe Val Val Arg Val 
            660                 665                 670         


Ala Asn Pro Ala Asn Ala Ser Phe Met Trp Leu Ser Pro Asp Val Glu 
        675                 680                 685             


Glu Arg Leu Lys Lys Ala Ala Ala Pro Arg Arg Gly Gly Arg Pro Ala 
    690                 695                 700                 


Gly Arg Gln Arg 
705             


<210> 644
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 644
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 645
<211> 985
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 645
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210> 646
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 646
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 647
<211> 985
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 647
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210> 648
<211> 1000
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 648
Met Glu Glu Ala Asn Arg Tyr Ile Tyr Gly Ala Tyr Phe Asn Met Ala 
1               5                   10                  15      


Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys Met Lys 
            20                  25                  30          


Leu Gly Ala Thr Ser Gly Phe Gly Lys Asp Gly Asn Glu Val Asn Asp 
        35                  40                  45              


Ile Asn Glu Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile Glu Asn 
    50                  55                  60                  


Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met Phe Tyr 
                85                  90                  95      


Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu Arg Asn 
            100                 105                 110         


Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu Ile Lys 
        115                 120                 125             


Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu Leu Asn 
    130                 135                 140                 


Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys Leu Arg 
145                 150                 155                 160 


Phe Met Ala Gly Glu Tyr Glu Val Ala His Leu Arg Arg Cys Lys Ala 
                165                 170                 175     


Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe Tyr Tyr 
            180                 185                 190         


Arg Leu Ser Asp Asn Gly Gly Val Thr Glu Lys Gly Val Ile Phe Ile 
        195                 200                 205             


Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu Lys Gln 
    210                 215                 220                 


Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu Thr Leu 
225                 230                 235                 240 


Glu Thr Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg Leu Lys 
                245                 250                 255     


Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Thr Lys Ile Pro Arg Glu Leu Ser Glu Thr Leu Ser Val Asp Cys 
        275                 280                 285             


Leu Tyr Lys Tyr Leu Thr Ser Asp Gly Glu Asp Asp Leu Arg Ser Arg 
    290                 295                 300                 


Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe Ile Ser 
305                 310                 315                 320 


Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr Thr Tyr Val Gly Asn 
                325                 330                 335     


Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr Asp Lys 
            340                 345                 350         


Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser Val Asn 
        355                 360                 365             


Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu Ile Lys 
    370                 375                 380                 


Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg Pro His 
385                 390                 395                 400 


Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn Ile Gly 
                405                 410                 415     


Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Ile Val Asn Gly Lys Gly 
            420                 425                 430         


Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu Leu Pro 
        435                 440                 445             


Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys Leu Leu 
    450                 455                 460                 


Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Asp Val Glu Lys Lys 
465                 470                 475                 480 


Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala Arg His 
                485                 490                 495     


Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu Val Lys 
            500                 505                 510         


Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly Arg Val 
        515                 520                 525             


Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp Met Val 
    530                 535                 540                 


Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly Ala Asn 
545                 550                 555                 560 


Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp Ile Leu 
                565                 570                 575     


Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His Arg His 
            580                 585                 590         


Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu Arg Asp 
        595                 600                 605             


Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu Asp Val 
    610                 615                 620                 


Ala Lys Lys Ile Ala Lys Asn Lys Leu Asn Thr Pro Cys His Ile Leu 
625                 630                 635                 640 


Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys Asp Val 
                645                 650                 655     


Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Gly Ser Ile Lys Ser 
            660                 665                 670         


Cys Leu Glu Lys Ser Ala Leu Asn Ile Asn Ile Arg Asn Ala Arg Asn 
        675                 680                 685             


Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu Ile Leu Met Tyr Tyr 
    690                 695                 700                 


Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu Lys Arg 
705                 710                 715                 720 


Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Asp Glu Arg 
                725                 730                 735     


Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val Ser Glu 
            740                 745                 750         


Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Met Arg Lys Arg Tyr 
        755                 760                 765             


His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln Val Gln 
    770                 775                 780                 


Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys Ala Leu 
785                 790                 795                 800 


Ser Glu Gly Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu Asn Gly 
                805                 810                 815     


Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn Ile Lys 
            820                 825                 830         


Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr Gly Lys Val Cys Arg 
        835                 840                 845             


Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Val Lys Ala Phe His Lys 
    850                 855                 860                 


Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu Lys Glu 
865                 870                 875                 880 


Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu Cys Arg 
                885                 890                 895     


Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu Asp Gly 
            900                 905                 910         


Lys Ser His Leu Gly Phe Asn Asp Asp Val Ile Lys Pro Tyr Asn Asp 
        915                 920                 925             


Lys Tyr Asn Val Phe Asn Gly Gly Asp Leu Thr Phe Phe Ile Asn Ala 
    930                 935                 940                 


Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val Lys Tyr 
945                 950                 955                 960 


Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser Phe Ala 
                965                 970                 975     


Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met Arg Lys 
            980                 985                 990         


Lys Thr Gly Leu Arg Ile Asp Ile  
        995                 1000 


<210> 649
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 649
Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 650
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 650
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 651
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 651
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 652
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 652
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 653
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 653
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Pro 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 654
<211> 985
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 654
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210> 655
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 655
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 656
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 656
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 657
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 657
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 658
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 658
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Lys Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 659
<211> 1150
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 659
Met Lys His Val Phe Ala Ala Tyr Phe Ser Asp Ala Arg Leu Asn Ile 
1               5                   10                  15      


Met Ala Ser Leu Asn Asp Val Arg Glu Lys Ser Gly Leu Lys Arg Tyr 
            20                  25                  30          


Lys Asn Glu Ala Glu Asn Val Gln Asn Phe Glu Gly Ile Phe Pro Lys 
        35                  40                  45              


Asn Ile Ala Ser Asp Ile Arg Asp Lys Arg Ile Thr Leu Leu Arg Ile 
    50                  55                  60                  


Arg Phe Pro Phe Ile Glu Thr Ile Val Asp Pro Gly Arg Gly Lys Glu 
65                  70                  75                  80  


Asn Pro Ala Ser Lys Tyr Gly Glu Leu Ser Trp Leu Phe Gln Leu Val 
                85                  90                  95      


Asn Asp Met Arg Asn Val Phe Ile His Ser Thr Gly Ser Glu Glu Glu 
            100                 105                 110         


Ile Asp Tyr Gln His His Lys Lys Ile Phe Asn Ala Leu Arg Lys Val 
        115                 120                 125             


Tyr Asp Cys Gly Leu Arg Thr Val Lys Ser Arg Phe Gln Leu Glu Asn 
    130                 135                 140                 


Asp Thr Thr Met Pro Leu Leu Arg Cys Asp Asn Arg Gly Arg Pro Lys 
145                 150                 155                 160 


Pro Phe Asn Lys Phe Ser Leu Ala Leu Cys Thr Ser Pro Glu Arg Asn 
                165                 170                 175     


Gly Asn Lys Lys Gln Ser Asp Val Leu His Asp Phe Gly Arg Val Leu 
            180                 185                 190         


Leu Cys Ser Leu Phe Leu Glu Lys Arg Gln Ile Ser Gly Leu Val Ser 
        195                 200                 205             


His Phe Trp Asp Lys Asn Gly Tyr Gly Thr Asp Trp Asn Asp Ser Glu 
    210                 215                 220                 


Gln Thr Ile Ile Arg Glu Leu Leu Tyr Val Asn Arg Ile Arg Leu Pro 
225                 230                 235                 240 


Ser Gln Arg Leu Arg Thr Asp Ser Thr Leu Thr Ser Val Thr Leu Asp 
                245                 250                 255     


Thr Ile Ser Glu Leu Ala Arg Cys Pro Arg Pro Leu Phe Glu Leu Leu 
            260                 265                 270         


Asp Ala Asp Gly Gln Glu Asn Phe Arg Val Gly Arg Ser Pro Lys Asn 
        275                 280                 285             


Pro Gln Asn Arg Asn Asp Asp Pro Ser Tyr Leu Leu Leu Arg Gly His 
    290                 295                 300                 


Gln Ser Arg Phe Ile Pro Leu Ala Met Arg His Leu Asp Phe Asp Ser 
305                 310                 315                 320 


Lys Cys Lys Leu Arg Phe Ala Val Asp Leu Gly Gln Tyr Tyr His Ser 
                325                 330                 335     


Val Arg Leu Lys Pro Ala Glu Ser Phe Ile Asp Gly Asn Pro Gly Ile 
            340                 345                 350         


Arg Arg Leu Gly Gln Lys Ile Ile Ala Phe Gly Arg Leu Lys Asp Phe 
        355                 360                 365             


Glu Asp Ala Glu Lys Pro Glu Ile Trp Lys Lys Leu Glu Glu Asn Gly 
    370                 375                 380                 


Gln Lys Phe Ala Glu Glu Glu Glu Glu Leu Leu Lys Arg Ala Ser Ile 
385                 390                 395                 400 


Thr Gly Ser Pro Glu Glu Leu Lys Pro Tyr Ile Ile Lys Thr Phe Pro 
                405                 410                 415     


His Tyr His Leu Tyr Arg Asp Lys Ile Gly Phe Cys Ile Asp Trp Glu 
            420                 425                 430         


Glu Lys Lys Asp Gln Lys Val Lys Tyr Pro Asn Leu Gly Val Arg Gly 
        435                 440                 445             


Glu Asp Ser Lys Ser Thr Asp Ser Gly Gly Ile Lys Lys Arg Glu Asn 
    450                 455                 460                 


Arg Gln Leu Ser Arg His Gln Phe Trp Ile Ser Pro Asn Lys Ile Ile 
465                 470                 475                 480 


Asp Leu Ala Phe Tyr His Tyr Leu Gln Thr Glu Ile Lys Gln Glu Ile 
                485                 490                 495     


Thr Ala Ser Val Lys Thr Gly Arg Lys Lys Cys Pro Tyr Pro Ser Val 
            500                 505                 510         


Glu Asn Ile Leu Lys Glu Tyr Tyr Glu Gly Met Val Val Leu Ile Lys 
        515                 520                 525             


Glu Leu Lys Glu Gln Gly Pro Leu Pro Pro Trp Thr Glu Ile Pro Gln 
    530                 535                 540                 


Ile Ser Glu Arg Arg Ala Glu Cys His Arg Trp Ile Asn Lys Glu Ile 
545                 550                 555                 560 


Ile Lys Ala Glu Asn Phe Thr Ile Ser Leu Ala Asp Leu Pro Lys Ala 
                565                 570                 575     


Ile Arg Arg His Leu Lys Val Leu Asp Ser Arg Glu Thr Ser Val Ser 
            580                 585                 590         


Asp Ile Ile Lys Arg Thr Lys Thr Met Ile Glu Glu Thr Cys Lys Lys 
        595                 600                 605             


Gln Lys Glu Ile Glu Tyr Leu Leu Lys Tyr Pro Lys Lys Arg Gly Lys 
    610                 615                 620                 


Lys Gly Phe Arg Pro Ile Lys His Gly Asn Ile Ala Asp Phe Leu Thr 
625                 630                 635                 640 


Glu Asp Leu Leu Arg Phe Gln Pro Lys Asp Ser Ser Lys Lys Asn Gly 
                645                 650                 655     


Gly Lys Leu Thr Ser Lys Asn Tyr Gln Ile Leu Gln Lys Ala Ile Ala 
            660                 665                 670         


Tyr Tyr Asp Lys Pro Tyr Cys Ile Val Asp Leu Leu Lys Lys Ser Gly 
        675                 680                 685             


Leu Leu Glu Gly Glu Phe Lys His Pro Phe Leu Cys Lys Ile Ile Thr 
    690                 695                 700                 


Glu Glu Asn His Glu Gln Tyr Ser Thr Leu Ile Asp Phe Tyr Gln Lys 
705                 710                 715                 720 


Tyr Leu Glu Glu Arg Lys Ala Phe Leu Glu Gly Phe Ile Asp Thr Phe 
                725                 730                 735     


Val Ala Gly Ser Ser Ile Pro Gly Trp Leu Arg Leu Arg Lys Pro Ser 
            740                 745                 750         


Thr Phe Glu Ser Trp Leu Asp Gln Gln Leu Asp Glu Asp Glu Lys Leu 
        755                 760                 765             


Cys Gln Pro Leu Pro Val Pro Lys Ser Leu Phe Tyr Gln Met Leu Leu 
    770                 775                 780                 


Lys Met Thr Ala Glu Lys Leu Asp Leu Thr Pro Glu Met Leu Cys Lys 
785                 790                 795                 800 


Lys Gly Thr Gln Arg Phe Ile Arg Asp Ser Gln Glu Val Glu Val Lys 
                805                 810                 815     


Pro Ser Val Ser Trp Phe Ile Arg Gln Tyr Met Glu His Arg Asp Asp 
            820                 825                 830         


Thr Ala Gln Glu Met Tyr Met Phe Lys Arg Arg His Glu Leu Phe Asp 
        835                 840                 845             


Phe Phe His Asp Lys Lys Lys Thr Thr Lys Lys Leu His Glu Glu Lys 
    850                 855                 860                 


Thr Cys Cys Leu Ser Glu Lys Val Arg Gln Glu Glu Leu Glu Ser Val 
865                 870                 875                 880 


His Lys Gly Ile Glu Lys Leu Lys Lys Leu Leu Arg Thr Tyr Lys Arg 
                885                 890                 895     


Ser Glu Lys Lys Ile Arg His Phe Ser Thr Met Asp Met Val Leu Tyr 
            900                 905                 910         


Leu Leu Ala Lys Lys Asn Phe Glu Lys Leu Ile Leu Cys Asp Glu Thr 
        915                 920                 925             


Ser Gly Pro Asp Trp Ser Leu Lys Thr Leu Glu Thr Lys Ile Leu Ser 
    930                 935                 940                 


Thr Lys Ile Lys Tyr Glu Leu Asn Val Pro Gly Thr Asp Arg Thr Ile 
945                 950                 955                 960 


Val His Arg Ala Cys Ala Ile Lys Lys Thr Gly Glu Leu Arg Leu Leu 
                965                 970                 975     


Val Arg Asp Arg Arg Leu Pro Ser Leu Leu Asp Tyr Tyr Pro Lys Thr 
            980                 985                 990         


Glu Lys Ser Ile Asp Gln Glu Glu  Ile Lys Val Glu Leu  Ala Asp Tyr 
        995                 1000                 1005             


Ser Cys  Lys Arg Ile Glu Ala  Met Lys Leu Ile Ser  Asp Leu Glu 
    1010                 1015                 1020             


Gln Lys  Ile Glu Glu Ser Cys  Asn Arg Gly Phe Cys  Lys Pro Val 
    1025                 1030                 1035             


Pro Asp  Lys Leu Lys Lys Ile  Phe Gly Ala Lys Lys  His Gly Thr 
    1040                 1045                 1050             


Leu Leu  Tyr Ala Leu Tyr His  Arg Phe His Glu Glu  Lys Asp Lys 
    1055                 1060                 1065             


Ser Val  Asp Glu Gln Gly Phe  Asn Lys Asp Cys Phe  Ala His Ala 
    1070                 1075                 1080             


Arg Gln  Ile Arg Asn Ala Phe  Ala His Asn Glu Tyr  Pro Val Ser 
    1085                 1090                 1095             


Glu Gln  Phe Asn Gln Ile Val  Arg Gln Val Asn Glu  Thr Ser Gln 
    1100                 1105                 1110             


Pro His  Asn His Asn Ser Pro  Val Asn His Pro Lys  Ile Ala Asp 
    1115                 1120                 1125             


Gln Leu  Val Lys Glu Leu Asp  Lys Leu Tyr Lys Pro  Trp Arg Asn 
    1130                 1135                 1140             


Phe Leu  Lys Arg Ile Ala Gly  
    1145                 1150 


<210> 660
<211> 985
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 660
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210> 661
<211> 985
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 661
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210> 662
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 662
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 663
<211> 985
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 663
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210> 664
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 664
Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 665
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 665
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Lys Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 666
<211> 985
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 666
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Lys His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg Thr Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Leu Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210> 667
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 667
Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 668
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 668
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 669
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 669
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 670
<211> 985
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 670
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210> 671
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 671
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Ala Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 672
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 672
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Pro 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 673
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 673
Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 674
<211> 1359
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 674
Met Gly Lys Leu Tyr Gly Tyr Lys Arg Trp Tyr Glu Ile Glu Gln Asn 
1               5                   10                  15      


Asn Gly Glu Lys Gly Ser Phe Lys Arg Lys Ile Arg Val Lys Arg Val 
            20                  25                  30          


Tyr Asp Glu Glu Ser Lys Ser Tyr Val Val Arg Arg Asp Glu Val Glu 
        35                  40                  45              


Asp Thr Glu Leu Ile Lys Asn Lys Asn Phe Ile Ile Asn Leu Lys Asp 
    50                  55                  60                  


Tyr Lys Thr Arg Asn Ser Asn Ile Gln Lys Phe Tyr Asp Lys Phe His 
65                  70                  75                  80  


Val Gly Asn Ile Leu Phe Lys Leu Lys Ala Ser Val Lys Lys Gly Lys 
                85                  90                  95      


Lys Thr Phe Tyr Lys Asp Leu Glu Lys Ala Glu Thr Val Leu Thr Asn 
            100                 105                 110         


Val Glu Ile Leu Glu Gln Thr Ile Lys Leu Ala Asn Asn Ser Lys Ile 
        115                 120                 125             


Asn Arg Lys Lys Leu Glu Lys Glu Leu Thr Gln Leu Asn Ile Asn Glu 
    130                 135                 140                 


Lys Ser Glu Glu Val Thr Ile Asp Asn Ile Lys Ile Tyr Leu Arg Gln 
145                 150                 155                 160 


Gly Glu Lys Phe Asp Lys Lys Glu Asn Ile Asn Ala Ile Lys Trp Arg 
                165                 170                 175     


Lys Leu Thr Ser Glu Glu Leu Thr Ile Lys Val Glu Ile Tyr Arg Glu 
            180                 185                 190         


Cys Gln Ser Ile Asn Ser Asn Leu Tyr Ser Leu Leu Asp Tyr Val Leu 
        195                 200                 205             


Ser Asn Glu Glu Tyr Asp Asp Arg Tyr Tyr Leu Glu Glu Val Glu Asn 
    210                 215                 220                 


Lys Leu Leu Ile Phe Gly Thr Gly Asn Lys Asn Lys Asn Gly Arg Asn 
225                 230                 235                 240 


Tyr Tyr Tyr Phe Asp Tyr Val Leu Lys Ser Leu Ser Lys Ile Lys Gly 
                245                 250                 255     


Leu Ile Lys Lys Asp Asp Arg Asn Leu Asn Tyr Leu Met Phe Leu Phe 
            260                 265                 270         


Asn Ile Gln Lys Thr Ser Glu Asn Lys Glu His Phe Ile Asn Lys Ile 
        275                 280                 285             


Phe Asn Tyr Phe Lys Tyr Glu Val Arg Ile Glu Lys Glu Asp Ile Val 
    290                 295                 300                 


Glu Phe Leu Val Gly Glu Leu Glu Tyr Tyr Asp Leu Ile Lys Arg Ile 
305                 310                 315                 320 


Glu Lys Lys Pro Ser Glu Asn Gln Asn Gln Thr Asn Leu Glu Lys Thr 
                325                 330                 335     


Tyr Ile Leu Leu Asp Lys His Glu Lys Leu Lys Glu Thr Ile Asp Thr 
            340                 345                 350         


Lys Asn Glu Ile Val Gln Lys Leu Thr Ile Glu Leu Lys Asn Asn Asn 
        355                 360                 365             


Leu Arg Asn Arg Ile Glu Ile Ile Leu His Lys Tyr Lys Ile Leu Glu 
    370                 375                 380                 


Leu Val Asp Lys Leu Asn Lys Asn Ile Lys Asn Gly Lys Ile Asn Thr 
385                 390                 395                 400 


Glu Leu Tyr Gly Ile Tyr Lys Glu His Tyr Gly Gln Cys Ile Glu Tyr 
                405                 410                 415     


Ile Asn Phe Asn Glu Leu Ala Leu Glu Glu Lys Glu Leu Tyr Lys Ile 
            420                 425                 430         


Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Leu Leu Gln Asn Arg 
        435                 440                 445             


Asn Lys Ile Lys Ile Gly Glu Leu Arg Ile Glu Asp Ile Phe Ile Phe 
    450                 455                 460                 


Gln Lys Leu Leu Glu Lys Ile Glu Ile Arg Val Lys Gln Tyr Leu Leu 
465                 470                 475                 480 


Glu His Ile Leu Tyr Leu Gly Lys Leu Lys His His Asn Ile Asp Glu 
                485                 490                 495     


Val Asn Thr Ile Arg Phe Val Glu Glu His Ala Asn Glu Glu Leu Ser 
            500                 505                 510         


Leu Glu Leu Ile Thr Leu Phe Ser Ala Thr Asn Val Glu Leu Asn Arg 
        515                 520                 525             


Leu Leu Lys Val Lys Gly Glu Asn Gly Ser Tyr Glu Lys Asp Tyr Asp 
    530                 535                 540                 


Phe Phe Ser Ala Lys Pro Asp Lys Gly Lys Ile Lys Ile Lys Asp Thr 
545                 550                 555                 560 


Asn Ser Val Met Lys Phe Glu Leu Leu Lys Lys Leu Lys Phe Ile Asn 
                565                 570                 575     


Ser Glu Ala Thr Glu Thr Asn Gln Glu Ala Ile Asp Phe Leu Lys Glu 
            580                 585                 590         


Ala Tyr Asn Leu Arg Asn Asn Ile Leu His Gly Lys Asn Glu Glu Ile 
        595                 600                 605             


Ile Glu Asp Asn Lys Lys Asn Leu Ser Lys Ser Tyr Lys Asn Ile Asn 
    610                 615                 620                 


Glu Leu Ile Glu Glu Leu Arg Pro Ser Asp Asn Glu Ile Cys Lys Ser 
625                 630                 635                 640 


Leu Asn Leu Asp Ile Ile Phe Lys Gly Asn Arg Lys Ile Asn Asp Ile 
                645                 650                 655     


Asn Ala Lys Leu Phe Gly Asn Asn Arg Glu Lys Ile Tyr Leu Pro Ser 
            660                 665                 670         


Phe Ser Lys Leu Val Pro Glu Ile Lys Asn Ile Ile Glu Ser Tyr Asp 
        675                 680                 685             


Lys Asn Gly Thr Phe Asn Asp Glu Arg Ile Lys Lys Ile Val Leu Asn 
    690                 695                 700                 


Gly Ala Ile Tyr Val Asn Lys Ile Leu Tyr Leu Lys Glu Cys Ser Asn 
705                 710                 715                 720 


Lys Asp Gly Glu Phe Ile Lys Asn Leu Lys Glu Glu Leu Asn Lys Asp 
                725                 730                 735     


Ser Lys Glu Lys Ser Lys Tyr Val Ser Ile Glu Glu Leu Tyr Lys Lys 
            740                 745                 750         


Ser Gln Ile Ser Ala Ser Lys Gly Asn Lys Lys Ala Ile Tyr Lys Tyr 
        755                 760                 765             


Gln Arg Lys Ile Ile Glu Ile Tyr Leu Lys Tyr Leu Lys Glu Asn Tyr 
    770                 775                 780                 


Val Glu Ile Leu Asp Phe Ser Lys Leu Asn Leu Asn Ile Glu Gln Ile 
785                 790                 795                 800 


Glu Asn Asp Ile Lys Asn Arg Lys Asn Ser Glu Asn Lys Val Leu Ile 
                805                 810                 815     


Glu Ser Ile Lys Gln Lys Val Phe Pro Glu Asn Asp Phe Glu Tyr Ile 
            820                 825                 830         


Ile Ser Ile Phe Ala Leu Leu Asn Asp Asn Ile Phe Ile Asn Lys Ile 
        835                 840                 845             


Arg Asn Arg Phe Phe Ser Thr Asp Thr Trp Leu Lys Asn Asn Arg Tyr 
    850                 855                 860                 


Ser Asn Ile Ile Lys Ile Leu Asp Glu Val Ile Ser Val Asn Leu Leu 
865                 870                 875                 880 


Arg Thr Glu Leu Leu Asn Thr Ser Ile Asp Ile Glu Glu Ile Lys Asp 
                885                 890                 895     


Asp Val Leu Thr Glu Asp Ile Glu Asn Ile Ile Pro Glu Ile Arg Glu 
            900                 905                 910         


Glu Ile Leu Gln Arg Thr Lys Lys Asp Phe Lys Thr Leu Leu Gly Asn 
        915                 920                 925             


Asn Ala Ile Ser Lys Glu Gly Leu Ser Asn Glu Asp Ile Asp Lys Ile 
    930                 935                 940                 


Arg Asn Ile Glu Asp Ala Lys Ile Asn Leu Asp Phe Val Asn Asn Glu 
945                 950                 955                 960 


Ile Lys Val Ser Leu Lys Glu Tyr Gly Ser Leu Pro Pro Asn Gly Val 
                965                 970                 975     


Leu Ser Arg Asn Thr Ser Lys Tyr Tyr Asn Asn Glu Ile Ala Lys Lys 
            980                 985                 990         


Ile Asp Gln Ile Ser Ile Leu Thr  Phe Thr Lys Lys Ser  Ile Gly Thr 
        995                 1000                 1005             


Ile Ser  Asp Glu Lys Phe Arg  Asn Ile Tyr Trp Gln  Glu Arg Lys 
    1010                 1015                 1020             


Glu Ser  Asp Glu Ser Lys Lys  Ile Phe Val Tyr Asn  Lys Asn Ile 
    1025                 1030                 1035             


Leu Tyr  Leu Val Thr Lys His  Ser Phe Glu Lys Leu  Tyr Lys Asn 
    1040                 1045                 1050             


Phe Leu  Glu Glu Glu Leu Asn  Asn Leu Lys Leu Glu  Asp Thr Lys 
    1055                 1060                 1065             


Tyr Leu  Arg Asp Leu Asp Leu  Arg Arg Glu Lys Asn  Leu Lys Val 
    1070                 1075                 1080             


Asp Asn  Thr Leu Lys Glu Ile  Asn Glu Lys Val Arg  Gly Tyr Ser 
    1085                 1090                 1095             


Lys Glu  Tyr Lys Lys Lys Phe  Ile Glu Asn Leu Lys  Asn Asn Asp 
    1100                 1105                 1110             


Glu Tyr  Phe Gly Lys Val Val  Ser Gly Arg Phe Lys  Asn Tyr Gln 
    1115                 1120                 1125             


Glu Phe  Lys Glu Ile Tyr Asp  Glu Val Ser Glu Tyr  Lys Lys Ile 
    1130                 1135                 1140             


Arg Asp  Val Val Asn Phe Asn  Pro Leu Asn Lys Val  Tyr Asn Tyr 
    1145                 1150                 1155             


Leu Ile  Glu Ile Asn Trp Lys  Leu Ala Ile Gln Met  Ala Arg Ala 
    1160                 1165                 1170             


Glu Arg  Asp Leu His Tyr Ile  Val Asn Gly Leu Asn  Glu Leu Lys 
    1175                 1180                 1185             


Leu Ile  Glu Leu Asn Gln Gly  Gln Asn Asp Gly Ile  Ser Arg Ala 
    1190                 1195                 1200             


Tyr Pro  Lys Tyr Lys Leu Asn  Lys Glu Lys Asn Lys  Lys Glu Leu 
    1205                 1210                 1215             


Arg Leu  Glu Glu Cys His Tyr  Asn Phe Asp Ile Asp  Asn Tyr Lys 
    1220                 1225                 1230             


Lys Phe  Glu Lys Ile Cys Glu  Lys Leu Gly Ile Asp  Leu Ser Glu 
    1235                 1240                 1245             


Asn Gly  Glu Leu Gln Gln Glu  Asn Glu Thr Asn Ile  Arg Asn Tyr 
    1250                 1255                 1260             


Ile Ser  His Phe Tyr Ile Leu  Arg Lys Pro Phe Val  Asp Ile Ser 
    1265                 1270                 1275             


Ile Ser  Glu Ala Ile Lys Arg  Val Ser Lys Leu Leu  Ser Tyr Arg 
    1280                 1285                 1290             


Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ser Ser Val Phe  Glu Val Phe 
    1295                 1300                 1305             


Lys Lys  Asp Val Glu Leu Asn  Tyr Asp Phe Leu Lys  Lys Lys Ile 
    1310                 1315                 1320             


Glu Leu  Asn Gly Lys Thr Tyr  Asp Glu Val Val Gln  Arg Lys Lys 
    1325                 1330                 1335             


Ile Ser  Cys Leu Glu Leu Glu  Ser Tyr Leu Asp Tyr  Lys Pro Ile 
    1340                 1345                 1350             


Ile Lys  Lys Ile Leu Phe 
    1355                 


<210> 675
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 675
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 676
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 676
Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 677
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 677
Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 678
<211> 1359
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 678
Met Gly Lys Leu Tyr Gly Tyr Lys Arg Trp Tyr Glu Ile Glu Gln Asn 
1               5                   10                  15      


Asn Gly Glu Lys Gly Ser Phe Lys Arg Lys Ile Arg Val Lys Arg Val 
            20                  25                  30          


Tyr Asp Glu Glu Ser Lys Ser Tyr Val Val Arg Arg Asp Glu Val Glu 
        35                  40                  45              


Asp Thr Glu Leu Ile Lys Asn Lys Asn Phe Ile Ile Asn Leu Lys Asp 
    50                  55                  60                  


Tyr Lys Thr Arg Asn Ser Asn Ile Gln Lys Phe Tyr Asp Lys Phe His 
65                  70                  75                  80  


Val Gly Asn Ile Leu Phe Lys Leu Lys Ala Ser Val Lys Lys Gly Lys 
                85                  90                  95      


Lys Thr Phe Tyr Lys Asp Leu Glu Lys Ala Glu Thr Val Leu Thr Asn 
            100                 105                 110         


Val Glu Ile Leu Glu Gln Thr Ile Lys Leu Ala Asn Asn Ser Lys Ile 
        115                 120                 125             


Asn Arg Lys Lys Leu Glu Lys Glu Leu Thr Gln Leu Asn Ile Asn Glu 
    130                 135                 140                 


Lys Ser Glu Glu Val Thr Ile Asp Asn Ile Lys Ile Tyr Leu Arg Gln 
145                 150                 155                 160 


Gly Glu Lys Phe Asp Lys Lys Glu Asn Ile Asn Ala Ile Lys Trp Arg 
                165                 170                 175     


Lys Leu Thr Ser Glu Glu Leu Thr Ile Lys Val Glu Ile Tyr Arg Glu 
            180                 185                 190         


Cys Gln Ser Ile Asn Ser Asn Leu Tyr Ser Leu Leu Asp Tyr Val Leu 
        195                 200                 205             


Ser Asn Glu Glu Tyr Asp Asp Arg Tyr Tyr Leu Glu Glu Val Glu Asn 
    210                 215                 220                 


Lys Leu Leu Ile Phe Gly Thr Gly Asn Lys Asn Lys Asn Gly Arg Asn 
225                 230                 235                 240 


Tyr Tyr Tyr Phe Asp Tyr Val Leu Lys Ser Leu Ser Lys Ile Lys Gly 
                245                 250                 255     


Leu Ile Lys Lys Asp Asp Arg Asn Leu Asn Tyr Leu Met Phe Leu Phe 
            260                 265                 270         


Asn Ile Gln Lys Thr Ser Glu Asn Lys Glu His Phe Ile Asn Lys Ile 
        275                 280                 285             


Phe Asn Tyr Phe Lys Tyr Glu Val Arg Ile Glu Lys Glu Asp Ile Val 
    290                 295                 300                 


Glu Phe Leu Val Gly Glu Leu Glu Tyr Tyr Asp Leu Ile Lys Arg Ile 
305                 310                 315                 320 


Glu Lys Lys Pro Ser Glu Asn Gln Asn Gln Thr Asn Leu Glu Lys Thr 
                325                 330                 335     


Tyr Ile Leu Leu Asp Lys His Glu Lys Leu Lys Glu Thr Ile Asp Thr 
            340                 345                 350         


Lys Asn Glu Ile Val Gln Lys Leu Thr Ile Glu Leu Lys Asn Asn Asn 
        355                 360                 365             


Leu Arg Asn Arg Ile Glu Ile Ile Leu His Lys Tyr Lys Ile Leu Glu 
    370                 375                 380                 


Leu Val Asp Lys Leu Asn Lys Asn Ile Lys Asn Gly Lys Ile Asn Thr 
385                 390                 395                 400 


Glu Leu Tyr Gly Ile Tyr Lys Glu His Tyr Gly Gln Cys Ile Glu Tyr 
                405                 410                 415     


Ile Asn Phe Asn Glu Leu Ala Leu Glu Glu Lys Glu Leu Tyr Lys Ile 
            420                 425                 430         


Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Leu Leu Gln Asn Arg 
        435                 440                 445             


Asn Lys Ile Lys Ile Gly Glu Leu Arg Ile Glu Asp Ile Phe Ile Phe 
    450                 455                 460                 


Gln Lys Leu Leu Glu Lys Ile Glu Ile Arg Val Lys Gln Tyr Leu Leu 
465                 470                 475                 480 


Glu His Ile Leu Tyr Leu Gly Lys Leu Lys His His Asn Ile Asp Glu 
                485                 490                 495     


Val Asn Thr Ile Arg Phe Val Glu Glu His Ala Asn Glu Glu Leu Ser 
            500                 505                 510         


Leu Glu Leu Ile Thr Leu Phe Ser Ala Thr Asn Val Glu Leu Asn Arg 
        515                 520                 525             


Leu Leu Lys Val Lys Gly Glu Asn Gly Ser Tyr Glu Lys Asp Tyr Asp 
    530                 535                 540                 


Phe Phe Ser Ala Lys Pro Asp Lys Gly Lys Ile Lys Ile Lys Asp Thr 
545                 550                 555                 560 


Asn Ser Val Met Lys Phe Glu Leu Leu Lys Lys Leu Lys Phe Ile Asn 
                565                 570                 575     


Ser Glu Ala Thr Glu Thr Asn Gln Glu Ala Ile Asp Phe Leu Lys Glu 
            580                 585                 590         


Ala Tyr Asn Leu Arg Asn Asn Ile Leu His Gly Lys Asn Glu Glu Ile 
        595                 600                 605             


Ile Glu Asp Asn Lys Lys Asn Leu Ser Lys Ser Tyr Lys Asn Ile Asn 
    610                 615                 620                 


Glu Leu Ile Glu Glu Leu Arg Pro Ser Asp Asn Glu Ile Cys Lys Ser 
625                 630                 635                 640 


Leu Asn Leu Asp Ile Ile Phe Lys Gly Asn Arg Lys Ile Asn Asp Ile 
                645                 650                 655     


Asn Ala Lys Leu Phe Gly Asn Asn Arg Glu Lys Ile Tyr Leu Pro Ser 
            660                 665                 670         


Phe Ser Lys Leu Val Pro Glu Ile Lys Asn Ile Ile Glu Ser Tyr Asp 
        675                 680                 685             


Lys Asn Gly Thr Phe Asn Asp Glu Arg Ile Lys Lys Ile Val Leu Asn 
    690                 695                 700                 


Gly Ala Ile Tyr Val Asn Lys Ile Leu Tyr Leu Lys Glu Cys Ser Asn 
705                 710                 715                 720 


Lys Asp Gly Glu Phe Ile Lys Asn Leu Lys Glu Glu Leu Asn Lys Asp 
                725                 730                 735     


Ser Lys Glu Lys Ser Lys Tyr Val Ser Ile Glu Glu Leu Tyr Lys Lys 
            740                 745                 750         


Ser Gln Ile Ser Ala Ser Lys Gly Asn Lys Lys Ala Ile Tyr Lys Tyr 
        755                 760                 765             


Gln Arg Lys Ile Ile Glu Ile Tyr Leu Lys Tyr Leu Lys Glu Asn Tyr 
    770                 775                 780                 


Val Glu Ile Leu Asp Phe Ser Lys Leu Asn Leu Asn Ile Glu Gln Ile 
785                 790                 795                 800 


Glu Asn Asp Ile Lys Asn Arg Lys Asn Ser Glu Asn Lys Val Leu Ile 
                805                 810                 815     


Glu Ser Ile Lys Gln Lys Val Phe Pro Glu Asn Asp Phe Glu Tyr Ile 
            820                 825                 830         


Ile Ser Ile Phe Ala Leu Leu Asn Asp Asn Ile Phe Ile Asn Lys Ile 
        835                 840                 845             


Arg Asn Arg Phe Phe Ser Thr Asp Thr Trp Leu Lys Asn Asn Arg Tyr 
    850                 855                 860                 


Ser Asn Ile Ile Lys Ile Leu Asp Glu Val Ile Ser Val Asn Leu Leu 
865                 870                 875                 880 


Arg Thr Glu Leu Leu Asn Thr Ser Ile Asp Ile Glu Glu Ile Lys Asp 
                885                 890                 895     


Asp Val Leu Thr Glu Asp Ile Glu Asn Ile Ile Pro Glu Ile Arg Glu 
            900                 905                 910         


Glu Ile Leu Gln Arg Thr Lys Lys Asp Phe Lys Thr Leu Leu Gly Asn 
        915                 920                 925             


Asn Ala Ile Ser Lys Glu Gly Leu Ser Asn Glu Asp Ile Asp Lys Ile 
    930                 935                 940                 


Arg Asn Ile Glu Asp Ala Lys Ile Asn Leu Asp Phe Val Asn Asn Glu 
945                 950                 955                 960 


Ile Lys Val Ser Leu Lys Glu Tyr Gly Ser Leu Pro Pro Asn Gly Val 
                965                 970                 975     


Leu Ser Arg Asn Thr Ser Lys Tyr Tyr Asn Asn Glu Ile Ala Lys Lys 
            980                 985                 990         


Ile Asp Gln Ile Ser Ile Leu Thr  Phe Thr Lys Lys Ser  Ile Gly Thr 
        995                 1000                 1005             


Ile Ser  Asp Glu Lys Phe Arg  Asn Ile Tyr Trp Gln  Glu Arg Lys 
    1010                 1015                 1020             


Glu Ser  Asp Glu Ser Lys Lys  Ile Phe Val Tyr Asn  Lys Asn Ile 
    1025                 1030                 1035             


Leu Tyr  Leu Val Thr Lys His  Ser Phe Glu Lys Leu  Tyr Lys Asn 
    1040                 1045                 1050             


Phe Leu  Glu Glu Glu Leu Asn  Asn Leu Lys Leu Glu  Asp Thr Lys 
    1055                 1060                 1065             


Tyr Leu  Arg Asp Leu Asp Leu  Arg Arg Glu Lys Asn  Leu Lys Val 
    1070                 1075                 1080             


Asp Asn  Thr Leu Lys Glu Ile  Asn Glu Lys Val Arg  Gly Tyr Ser 
    1085                 1090                 1095             


Lys Glu  Tyr Lys Lys Lys Phe  Ile Glu Asn Leu Lys  Asn Asn Asp 
    1100                 1105                 1110             


Glu Tyr  Phe Gly Lys Val Val  Ser Gly Arg Phe Lys  Asn Tyr Gln 
    1115                 1120                 1125             


Glu Phe  Lys Glu Ile Tyr Asp  Glu Val Ser Glu Tyr  Lys Lys Ile 
    1130                 1135                 1140             


Arg Asp  Val Val Asn Phe Asn  Pro Leu Asn Lys Val  Tyr Asn Tyr 
    1145                 1150                 1155             


Leu Ile  Glu Ile Asn Trp Lys  Leu Ala Ile Gln Met  Ala Arg Ala 
    1160                 1165                 1170             


Glu Arg  Asp Leu His Tyr Ile  Val Asn Gly Leu Asn  Glu Leu Lys 
    1175                 1180                 1185             


Leu Ile  Glu Leu Asn Gln Gly  Gln Asn Asp Gly Ile  Ser Arg Ala 
    1190                 1195                 1200             


Tyr Pro  Lys Tyr Lys Leu Asn  Lys Glu Lys Asn Lys  Lys Glu Leu 
    1205                 1210                 1215             


Arg Leu  Glu Glu Cys His Tyr  Asn Phe Asp Ile Asp  Asn Tyr Lys 
    1220                 1225                 1230             


Lys Phe  Glu Lys Ile Cys Glu  Lys Leu Gly Ile Asp  Leu Ser Glu 
    1235                 1240                 1245             


Asn Gly  Glu Leu Gln Gln Glu  Asn Glu Thr Asn Ile  Arg Asn Tyr 
    1250                 1255                 1260             


Ile Ser  His Phe Tyr Ile Leu  Arg Lys Pro Phe Val  Asp Ile Ser 
    1265                 1270                 1275             


Ile Ser  Glu Ala Ile Lys Arg  Val Ser Lys Leu Leu  Ser Tyr Arg 
    1280                 1285                 1290             


Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ser Ser Val Phe  Glu Val Phe 
    1295                 1300                 1305             


Lys Lys  Asp Val Glu Leu Asn  Tyr Asp Phe Leu Lys  Lys Lys Ile 
    1310                 1315                 1320             


Glu Leu  Asn Gly Lys Thr Tyr  Asp Glu Val Val Gln  Arg Lys Lys 
    1325                 1330                 1335             


Ile Ser  Cys Leu Glu Leu Glu  Ser Tyr Leu Asp Tyr  Lys Pro Ile 
    1340                 1345                 1350             


Ile Lys  Lys Ile Leu Phe 
    1355                 


<210> 679
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 679
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Arg Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 680
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 680
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 681
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 681
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Ile Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Val Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 682
<211> 985
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 682
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Lys His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg Thr Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Leu Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210> 683
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 683
Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 684
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 684
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 685
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 685
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 686
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 686
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 687
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 687
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 688
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 688
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 689
<211> 1008
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 689
Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210> 690
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 690
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 691
<211> 1224
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 691
Met Glu Asn Lys Thr Ser Leu Gly Asn Asn Ile Tyr Tyr Asn Pro Phe 
1               5                   10                  15      


Lys Pro Gln Asp Lys Ser Tyr Phe Ala Gly Tyr Phe Asn Ala Ala Met 
            20                  25                  30          


Glu Asn Thr Asp Ser Val Phe Arg Glu Leu Gly Lys Arg Leu Lys Gly 
        35                  40                  45              


Lys Glu Tyr Thr Ser Glu Asn Phe Phe Asp Ala Ile Phe Lys Glu Asn 
    50                  55                  60                  


Ile Ser Leu Val Glu Tyr Glu Arg Tyr Val Lys Leu Leu Ser Asp Tyr 
65                  70                  75                  80  


Phe Pro Met Ala Arg Leu Leu Asp Lys Lys Glu Val Pro Ile Lys Glu 
                85                  90                  95      


Arg Lys Glu Asn Phe Lys Lys Asn Phe Lys Gly Ile Ile Lys Ala Val 
            100                 105                 110         


Arg Asp Leu Arg Asn Phe Tyr Thr His Lys Glu His Gly Glu Val Glu 
        115                 120                 125             


Ile Thr Asp Glu Ile Phe Gly Val Leu Asp Glu Met Leu Lys Ser Thr 
    130                 135                 140                 


Val Leu Thr Val Lys Lys Lys Lys Val Lys Thr Asp Lys Thr Lys Glu 
145                 150                 155                 160 


Ile Leu Lys Lys Ser Ile Glu Lys Gln Leu Asp Ile Leu Cys Gln Lys 
                165                 170                 175     


Lys Leu Glu Tyr Leu Arg Asp Thr Ala Arg Lys Ile Glu Glu Lys Arg 
            180                 185                 190         


Arg Asn Gln Arg Glu Arg Gly Glu Lys Glu Leu Val Ala Pro Phe Lys 
        195                 200                 205             


Tyr Ser Asp Lys Arg Asp Asp Leu Ile Ala Ala Ile Tyr Asn Asp Ala 
    210                 215                 220                 


Phe Asp Val Tyr Ile Asp Lys Lys Lys Asp Ser Leu Lys Glu Ser Ser 
225                 230                 235                 240 


Lys Ala Lys Tyr Asn Thr Lys Ser Asp Pro Gln Gln Glu Glu Gly Asp 
                245                 250                 255     


Leu Lys Ile Pro Ile Ser Lys Asn Gly Val Val Phe Leu Leu Ser Leu 
            260                 265                 270         


Phe Leu Thr Lys Gln Glu Ile His Ala Phe Lys Ser Lys Ile Ala Gly 
        275                 280                 285             


Phe Lys Ala Thr Val Ile Asp Glu Ala Thr Val Ser Glu Ala Thr Val 
    290                 295                 300                 


Ser His Gly Lys Asn Ser Ile Cys Phe Met Ala Thr His Glu Ile Phe 
305                 310                 315                 320 


Ser His Leu Ala Tyr Lys Lys Leu Lys Arg Lys Val Arg Thr Ala Glu 
                325                 330                 335     


Ile Asn Tyr Gly Glu Ala Glu Asn Ala Glu Gln Leu Ser Val Tyr Ala 
            340                 345                 350         


Lys Glu Thr Leu Met Met Gln Met Leu Asp Glu Leu Ser Lys Val Pro 
        355                 360                 365             


Asp Val Val Tyr Gln Asn Leu Ser Glu Asp Val Gln Lys Thr Phe Ile 
    370                 375                 380                 


Glu Asp Trp Asn Glu Tyr Leu Lys Glu Asn Asn Gly Asp Val Gly Thr 
385                 390                 395                 400 


Met Glu Glu Glu Gln Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu 
                405                 410                 415     


Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Gln 
            420                 425                 430         


Phe Pro Thr Leu Arg Phe Gln Val His Leu Gly Asn Tyr Leu His Asp 
        435                 440                 445             


Ser Arg Pro Lys Glu Asn Leu Ile Ser Asp Arg Arg Ile Lys Glu Lys 
    450                 455                 460                 


Ile Thr Val Phe Gly Arg Leu Ser Glu Leu Glu His Lys Lys Ala Leu 
465                 470                 475                 480 


Phe Ile Lys Asn Thr Glu Thr Asn Glu Asp Arg Glu His Tyr Trp Glu 
                485                 490                 495     


Ile Phe Pro Asn Pro Asn Tyr Asp Phe Pro Lys Glu Asn Ile Ser Val 
            500                 505                 510         


Asn Asp Lys Asp Phe Pro Ile Ala Gly Ser Ile Leu Asp Arg Glu Lys 
        515                 520                 525             


Gln Pro Val Ala Gly Lys Ile Gly Ile Lys Val Lys Leu Leu Asn Gln 
    530                 535                 540                 


Gln Tyr Val Ser Glu Val Asp Lys Ala Val Lys Ala His Gln Leu Lys 
545                 550                 555                 560 


Gln Arg Lys Ala Ser Lys Pro Ser Ile Gln Asn Ile Ile Glu Glu Ile 
                565                 570                 575     


Val Pro Ile Asn Glu Ser Asn Pro Lys Glu Ala Ile Val Phe Gly Gly 
            580                 585                 590         


Gln Pro Thr Ala Tyr Leu Ser Met Asn Asp Ile His Ser Ile Leu Tyr 
        595                 600                 605             


Glu Phe Phe Asp Lys Trp Glu Lys Lys Lys Glu Lys Leu Glu Lys Lys 
    610                 615                 620                 


Gly Glu Lys Glu Leu Arg Lys Glu Ile Gly Lys Glu Leu Glu Lys Lys 
625                 630                 635                 640 


Ile Val Gly Lys Ile Gln Ala Gln Ile Gln Gln Ile Ile Asp Lys Asp 
                645                 650                 655     


Thr Asn Ala Lys Ile Leu Lys Pro Tyr Gln Asp Gly Asn Ser Thr Ala 
            660                 665                 670         


Ile Asp Lys Glu Lys Leu Ile Lys Asp Leu Lys Gln Glu Gln Asn Ile 
        675                 680                 685             


Leu Gln Lys Leu Lys Asp Glu Gln Thr Val Arg Glu Lys Glu Tyr Asn 
    690                 695                 700                 


Asp Phe Ile Ala Tyr Gln Asp Lys Asn Arg Glu Ile Asn Lys Val Arg 
705                 710                 715                 720 


Asp Arg Asn His Lys Gln Tyr Leu Lys Asp Asn Leu Lys Arg Lys Tyr 
                725                 730                 735     


Pro Glu Ala Pro Ala Arg Lys Glu Val Leu Tyr Tyr Arg Glu Lys Gly 
            740                 745                 750         


Lys Val Ala Val Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Thr 
        755                 760                 765             


Asp Phe Lys Asn Glu Trp Lys Gly Glu Gln His Ser Leu Leu Gln Lys 
    770                 775                 780                 


Ser Leu Ala Tyr Tyr Glu Gln Cys Lys Glu Glu Leu Lys Asn Leu Leu 
785                 790                 795                 800 


Pro Glu Lys Val Phe Gln His Leu Pro Phe Lys Leu Gly Gly Tyr Phe 
                805                 810                 815     


Gln Gln Lys Tyr Leu Tyr Gln Phe Tyr Thr Cys Tyr Leu Asp Lys Arg 
            820                 825                 830         


Leu Glu Tyr Ile Ser Gly Leu Val Gln Gln Ala Glu Asn Phe Lys Ser 
        835                 840                 845             


Glu Asn Lys Val Phe Lys Lys Val Glu Asn Glu Cys Phe Lys Phe Leu 
    850                 855                 860                 


Lys Lys Gln Asn Tyr Thr His Lys Glu Leu Asp Ala Arg Val Gln Ser 
865                 870                 875                 880 


Ile Leu Gly Tyr Pro Ile Phe Leu Glu Arg Gly Phe Met Asp Glu Lys 
                885                 890                 895     


Pro Thr Ile Ile Lys Gly Lys Thr Phe Lys Gly Asn Glu Ala Leu Phe 
            900                 905                 910         


Ala Asp Trp Phe Arg Tyr Tyr Lys Glu Tyr Gln Asn Phe Gln Thr Phe 
        915                 920                 925             


Tyr Asp Thr Glu Asn Tyr Pro Leu Val Glu Leu Glu Lys Lys Gln Ala 
    930                 935                 940                 


Asp Arg Lys Arg Lys Thr Lys Ile Tyr Gln Gln Lys Lys Asn Asp Val 
945                 950                 955                 960 


Phe Thr Leu Leu Met Ala Lys His Ile Phe Lys Ser Val Phe Lys Gln 
                965                 970                 975     


Asp Ser Ile Asp Gln Phe Ser Leu Glu Asp Leu Tyr Gln Ser Arg Glu 
            980                 985                 990         


Glu Arg Leu Gly Asn Gln Glu Arg  Ala Arg Gln Thr Gly  Glu Arg Asn 
        995                 1000                 1005             


Thr Asn  Tyr Ile Trp Asn Lys  Thr Val Asp Leu Lys  Leu Cys Asp 
    1010                 1015                 1020             


Gly Lys  Ile Thr Val Glu Asn  Val Lys Leu Lys Asn  Val Gly Asp 
    1025                 1030                 1035             


Phe Ile  Lys Tyr Glu Tyr Asp  Gln Arg Val Gln Ala  Phe Leu Lys 
    1040                 1045                 1050             


Tyr Glu  Glu Asn Ile Glu Trp  Gln Ala Phe Leu Ile  Lys Glu Ser 
    1055                 1060                 1065             


Lys Glu  Glu Glu Asn Tyr Pro  Tyr Val Val Glu Arg  Glu Ile Glu 
    1070                 1075                 1080             


Gln Tyr  Glu Lys Val Arg Arg  Glu Glu Leu Leu Lys  Glu Val His 
    1085                 1090                 1095             


Leu Ile  Glu Glu Tyr Ile Leu  Glu Lys Val Lys Asp  Lys Glu Ile 
    1100                 1105                 1110             


Leu Lys  Lys Gly Asp Asn Gln  Asn Phe Lys Tyr Tyr  Ile Leu Asn 
    1115                 1120                 1125             


Gly Leu  Leu Lys Gln Leu Lys  Asn Glu Asp Val Glu  Ser Tyr Lys 
    1130                 1135                 1140             


Val Phe  Asn Leu Asn Thr Glu  Pro Glu Asp Val Asn  Ile Asn Gln 
    1145                 1150                 1155             


Leu Lys  Gln Glu Ala Thr Asp  Leu Glu Gln Lys Ala  Phe Val Leu 
    1160                 1165                 1170             


Thr Tyr  Ile Arg Asn Lys Phe  Ala His Asn Gln Leu  Pro Lys Lys 
    1175                 1180                 1185             


Glu Phe  Trp Asp Tyr Cys Gln  Glu Lys Tyr Gly Lys  Ile Glu Lys 
    1190                 1195                 1200             


Glu Lys  Thr Tyr Ala Glu Tyr  Phe Ala Glu Val Phe  Lys Lys Glu 
    1205                 1210                 1215             


Lys Glu  Ala Leu Ile Lys 
    1220                 


<210> 692
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 692
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 693
<211> 1174
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 693
Met Thr Glu Gln Ser Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Gln Asp Val Leu Ser Phe Lys Ala Leu Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ser Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Lys Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Ser Gly Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Tyr His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly His Asn Asp Asn Pro Ser Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Ser Glu Gly Met Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Gly Pro Tyr Glu Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Pro Leu Tyr Asp Arg Leu Arg Glu Lys Asp Arg Ala Cys Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Pro Asp Glu Asp Asp Thr Asp Gly Gly 
                325                 330                 335     


Gly Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Met Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Leu Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Ser Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Thr Thr Arg Thr Gly Arg Ser Lys Cys Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Ile Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Leu Lys 
    530                 535                 540                 


Glu Leu Asp Thr Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Lys Gln Met Ile Thr Ile Leu Ser Gln Glu Arg Lys Asp Met Lys 
                565                 570                 575     


Glu Lys Ile Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Ala Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Arg Ala Arg Lys Ala Phe Leu Glu Arg Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn Cys Pro Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Asp Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Arg Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Glu Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Ser Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Arg Gly 
            820                 825                 830         


Met Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Lys Asp Ala Phe Ala Gly Ile Glu Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Arg Asp Leu Ser Leu Trp Glu Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Arg Ala Asp Lys Ile Asn Leu Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Gln Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Pro 
945                 950                 955                 960 


Asn Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Ala Pro Leu Ala Thr  Val Tyr Ile Glu Glu  Arg Asn Thr 
        995                 1000                 1005             


Lys Leu  Leu Lys Gln Gly Asn  Phe Lys Ser Phe Val  Lys Asp Arg 
    1010                 1015                 1020             


Arg Leu  Asn Gly Leu Phe Ser  Phe Val Asp Thr Gly  Gly Leu Ala 
    1025                 1030                 1035             


Met Glu  Gln Tyr Pro Ile Ser  Lys Leu Arg Val Glu  Tyr Glu Leu 
    1040                 1045                 1050             


Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Val Phe Glu  Leu Thr Leu 
    1055                 1060                 1065             


Arg Leu  Glu Glu Ser Leu Leu  Ser Arg Tyr Pro His  Leu Pro Asp 
    1070                 1075                 1080             


Glu Ser  Phe Arg Glu Met Leu  Glu Ser Trp Ser Asp  Pro Leu Leu 
    1085                 1090                 1095             


Ala Lys  Trp Pro Glu Leu His  Gly Lys Val Arg Leu  Leu Ile Ala 
    1100                 1105                 1110             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  Tyr Asp Glu 
    1115                 1120                 1125             


Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp Pro Ser  Ser Pro Asp 
    1130                 1135                 1140             


Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile Ala His  Arg Leu Ser 
    1145                 1150                 1155             


Glu Glu  Val Lys Gln Ala Lys  Glu Thr Val Glu Arg  Ile Ile Gln 
    1160                 1165                 1170             


Ala 
    


<210> 694
<211> 1103
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 694
Met Glu Lys Pro Leu Pro Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Thr Thr Pro Pro Asn Asp 
        35                  40                  45              


Asp Lys Ile Ala Asp Val Val Cys Gly Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Ala Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly Ser Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Asn Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Glu Leu Ile 
        115                 120                 125             


Lys Ala Leu Lys Thr Leu Val Lys Gln Leu Arg Thr Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Gln Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Lys Phe Asp Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Ser Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Lys Asp 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Ala Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Lys Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Val Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Asp Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Asp 
            580                 585                 590         


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Val 
        595                 600                 605             


Gln Asn Gln Pro Ile Glu Ser Ser Lys Ala Asn Ser Thr Glu Phe Gln 
    610                 615                 620                 


Leu Ile Gln Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
625                 630                 635                 640 


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
                645                 650                 655     


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
            660                 665                 670         


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
        675                 680                 685             


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
    690                 695                 700                 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
705                 710                 715                 720 


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
                725                 730                 735     


Ser Glu Asp Leu Thr Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
            740                 745                 750         


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Arg 
        755                 760                 765             


Glu Arg Tyr Gln Asp Asp His Gln Ser Phe Tyr Asn Leu Pro Tyr Glu 
    770                 775                 780                 


Leu Glu Ala Lys Ala Ser Thr Pro Lys Pro Pro Leu Pro Lys Lys Arg 
785                 790                 795                 800 


Glu Tyr Val Leu Arg Ala Glu His Tyr Glu Tyr Trp Gln Gln Asn Lys 
                805                 810                 815     


Pro Gln Ser Pro Thr Glu Leu Gln Arg Leu Glu Leu His Thr Ser Asp 
            820                 825                 830         


Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp Gln His Leu Glu Lys 
        835                 840                 845             


Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met Leu Trp Leu Met Thr 
    850                 855                 860                 


Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu Lys Leu Asn Tyr His 
865                 870                 875                 880 


Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val Gln Glu Ala Asp Ala 
                885                 890                 895     


Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met Val Leu Pro Val Lys 
            900                 905                 910         


Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln Tyr Gln Glu Thr Pro 
        915                 920                 925             


Ile Arg Thr Val Tyr Ile Arg Glu Glu Gln Thr Lys Ala Leu Lys Met 
    930                 935                 940                 


Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe 
945                 950                 955                 960 


Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys His Pro Ile Ser Gln 
                965                 970                 975     


Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln Ser Leu Arg Val Asp 
            980                 985                 990         


Ala Phe Lys Glu Thr Leu Ser Leu  Glu Glu Lys Leu Leu  Asn Lys His 
        995                 1000                 1005             


Ala Ser  Leu Ser Ser Leu Glu  Asn Glu Phe Arg Thr  Leu Leu Glu 
    1010                 1015                 1020             


Glu Trp  Lys Lys Lys Tyr Ala  Ala Ser Ser Met Val  Thr Asp Glu 
    1025                 1030                 1035             


His Ile  Ala Phe Ile Ala Ser  Val Arg Asn Ala Phe  Cys His Asn 
    1040                 1045                 1050             


Gln Tyr  Pro Phe Tyr Lys Glu  Thr Leu His Ala Pro  Ile Leu Leu 
    1055                 1060                 1065             


Phe Thr  Val Ala Gln Pro Thr  Thr Glu Glu Lys Asp  Gly Leu Gly 
    1070                 1075                 1080             


Ile Ala  Glu Ala Leu Leu Arg  Val Leu Arg Glu Tyr  Cys Glu Ile 
    1085                 1090                 1095             


Val Lys  Ser Gln Ile 
    1100             


<210> 695
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 695
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 696
<211> 1224
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 696
Met Glu Asn Lys Thr Ser Leu Gly Asn Asn Ile Tyr Tyr Asn Pro Phe 
1               5                   10                  15      


Lys Pro Gln Asp Lys Ser Tyr Phe Ala Gly Tyr Phe Asn Ala Ala Met 
            20                  25                  30          


Glu Asn Thr Asp Ser Val Phe Arg Glu Leu Gly Lys Arg Leu Lys Gly 
        35                  40                  45              


Lys Glu Tyr Thr Ser Glu Asn Phe Phe Asp Ala Ile Phe Lys Glu Asn 
    50                  55                  60                  


Ile Ser Leu Val Glu Tyr Glu Arg Tyr Val Lys Leu Leu Ser Asp Tyr 
65                  70                  75                  80  


Phe Pro Met Ala Arg Leu Leu Asp Lys Lys Glu Val Pro Ile Lys Glu 
                85                  90                  95      


Arg Lys Glu Asn Phe Lys Lys Asn Phe Lys Gly Ile Ile Lys Ala Val 
            100                 105                 110         


Arg Asp Leu Arg Asn Phe Tyr Thr His Lys Glu His Gly Glu Val Glu 
        115                 120                 125             


Ile Thr Asp Glu Ile Phe Gly Val Leu Asp Glu Met Leu Lys Ser Thr 
    130                 135                 140                 


Val Leu Thr Val Lys Lys Lys Lys Val Lys Thr Asp Lys Thr Lys Glu 
145                 150                 155                 160 


Ile Leu Lys Lys Ser Ile Glu Lys Gln Leu Asp Ile Leu Cys Gln Lys 
                165                 170                 175     


Lys Leu Glu Tyr Leu Arg Asp Thr Ala Arg Lys Ile Glu Glu Lys Arg 
            180                 185                 190         


Arg Asn Gln Arg Glu Arg Gly Glu Lys Glu Leu Val Ala Pro Phe Lys 
        195                 200                 205             


Tyr Ser Asp Lys Arg Asp Asp Leu Ile Ala Ala Ile Tyr Asn Asp Ala 
    210                 215                 220                 


Phe Asp Val Tyr Ile Asp Lys Lys Lys Asp Ser Leu Lys Glu Ser Ser 
225                 230                 235                 240 


Lys Ala Lys Tyr Asn Thr Lys Ser Asp Pro Gln Gln Glu Glu Gly Asp 
                245                 250                 255     


Leu Lys Ile Pro Ile Ser Lys Asn Gly Val Val Phe Leu Leu Ser Leu 
            260                 265                 270         


Phe Leu Thr Lys Gln Glu Ile His Ala Phe Lys Ser Lys Ile Ala Gly 
        275                 280                 285             


Phe Lys Ala Thr Val Ile Asp Glu Ala Thr Val Ser Glu Ala Thr Val 
    290                 295                 300                 


Ser His Gly Lys Asn Ser Ile Cys Phe Met Ala Thr His Glu Ile Phe 
305                 310                 315                 320 


Ser His Leu Ala Tyr Lys Lys Leu Lys Arg Lys Val Arg Thr Ala Glu 
                325                 330                 335     


Ile Asn Tyr Gly Glu Ala Glu Asn Ala Glu Gln Leu Ser Val Tyr Ala 
            340                 345                 350         


Lys Glu Thr Leu Met Met Gln Met Leu Asp Glu Leu Ser Lys Val Pro 
        355                 360                 365             


Asp Val Val Tyr Gln Asn Leu Ser Glu Asp Val Gln Lys Thr Phe Ile 
    370                 375                 380                 


Glu Asp Trp Asn Glu Tyr Leu Lys Glu Asn Asn Gly Asp Val Gly Thr 
385                 390                 395                 400 


Met Glu Glu Glu Gln Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu 
                405                 410                 415     


Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Gln 
            420                 425                 430         


Phe Pro Thr Leu Arg Phe Gln Val His Leu Gly Asn Tyr Leu His Asp 
        435                 440                 445             


Ser Arg Pro Lys Glu Asn Leu Ile Ser Asp Arg Arg Ile Lys Glu Lys 
    450                 455                 460                 


Ile Thr Val Phe Gly Arg Leu Ser Glu Leu Glu His Lys Lys Ala Leu 
465                 470                 475                 480 


Phe Ile Lys Asn Thr Glu Thr Asn Glu Asp Arg Glu His Tyr Trp Glu 
                485                 490                 495     


Ile Phe Pro Asn Pro Asn Tyr Asp Phe Pro Lys Glu Asn Ile Ser Val 
            500                 505                 510         


Asn Asp Lys Asp Phe Pro Ile Ala Gly Ser Ile Leu Asp Arg Glu Lys 
        515                 520                 525             


Gln Pro Val Ala Gly Lys Ile Gly Ile Lys Val Lys Leu Leu Asn Gln 
    530                 535                 540                 


Gln Tyr Val Ser Glu Val Asp Lys Ala Val Lys Ala His Gln Leu Lys 
545                 550                 555                 560 


Gln Arg Lys Ala Ser Lys Pro Ser Ile Gln Asn Ile Ile Glu Glu Ile 
                565                 570                 575     


Val Pro Ile Asn Glu Ser Asn Pro Lys Glu Ala Ile Val Phe Gly Gly 
            580                 585                 590         


Gln Pro Thr Ala Tyr Leu Ser Met Asn Asp Ile His Ser Ile Leu Tyr 
        595                 600                 605             


Glu Phe Phe Asp Lys Trp Glu Lys Lys Lys Glu Lys Leu Glu Lys Lys 
    610                 615                 620                 


Gly Glu Lys Glu Leu Arg Lys Glu Ile Gly Lys Glu Leu Glu Lys Lys 
625                 630                 635                 640 


Ile Val Gly Lys Ile Gln Ala Gln Ile Gln Gln Ile Ile Asp Lys Asp 
                645                 650                 655     


Thr Asn Ala Lys Ile Leu Lys Pro Tyr Gln Asp Gly Asn Ser Thr Ala 
            660                 665                 670         


Ile Asp Lys Glu Lys Leu Ile Lys Asp Leu Lys Gln Glu Gln Asn Ile 
        675                 680                 685             


Leu Gln Lys Leu Lys Asp Glu Gln Thr Val Arg Glu Lys Glu Tyr Asn 
    690                 695                 700                 


Asp Phe Ile Ala Tyr Gln Asp Lys Asn Arg Glu Ile Asn Lys Val Arg 
705                 710                 715                 720 


Asp Arg Asn His Lys Gln Tyr Leu Lys Asp Asn Leu Lys Arg Lys Tyr 
                725                 730                 735     


Pro Glu Ala Pro Ala Arg Lys Glu Val Leu Tyr Tyr Arg Glu Lys Gly 
            740                 745                 750         


Lys Val Ala Val Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Thr 
        755                 760                 765             


Asp Phe Lys Asn Glu Trp Lys Gly Glu Gln His Ser Leu Leu Gln Lys 
    770                 775                 780                 


Ser Leu Ala Tyr Tyr Glu Gln Cys Lys Glu Glu Leu Lys Asn Leu Leu 
785                 790                 795                 800 


Pro Glu Lys Val Phe Gln His Leu Pro Phe Lys Leu Gly Gly Tyr Phe 
                805                 810                 815     


Gln Gln Lys Tyr Leu Tyr Gln Phe Tyr Thr Cys Tyr Leu Asp Lys Arg 
            820                 825                 830         


Leu Glu Tyr Ile Ser Gly Leu Val Gln Gln Ala Glu Asn Phe Lys Ser 
        835                 840                 845             


Glu Asn Lys Val Phe Lys Lys Val Glu Asn Glu Cys Phe Lys Phe Leu 
    850                 855                 860                 


Lys Lys Gln Asn Tyr Thr His Lys Glu Leu Asp Ala Arg Val Gln Ser 
865                 870                 875                 880 


Ile Leu Gly Tyr Pro Ile Phe Leu Glu Arg Gly Phe Met Asp Glu Lys 
                885                 890                 895     


Pro Thr Ile Ile Lys Gly Lys Thr Phe Lys Gly Asn Glu Ala Leu Phe 
            900                 905                 910         


Ala Asp Trp Phe Arg Tyr Tyr Lys Glu Tyr Gln Asn Phe Gln Thr Phe 
        915                 920                 925             


Tyr Asp Thr Glu Asn Tyr Pro Leu Val Glu Leu Glu Lys Lys Gln Ala 
    930                 935                 940                 


Asp Arg Lys Arg Lys Thr Lys Ile Tyr Gln Gln Lys Lys Asn Asp Val 
945                 950                 955                 960 


Phe Thr Leu Leu Met Ala Lys His Ile Phe Lys Ser Val Phe Lys Gln 
                965                 970                 975     


Asp Ser Ile Asp Gln Phe Ser Leu Glu Asp Leu Tyr Gln Ser Arg Glu 
            980                 985                 990         


Glu Arg Leu Gly Asn Gln Glu Arg  Ala Arg Gln Thr Gly  Glu Arg Asn 
        995                 1000                 1005             


Thr Asn  Tyr Ile Trp Asn Lys  Thr Val Asp Leu Lys  Leu Cys Asp 
    1010                 1015                 1020             


Gly Lys  Ile Thr Val Glu Asn  Val Lys Leu Lys Asn  Val Gly Asp 
    1025                 1030                 1035             


Phe Ile  Lys Tyr Glu Tyr Asp  Gln Arg Val Gln Ala  Phe Leu Lys 
    1040                 1045                 1050             


Tyr Glu  Glu Asn Ile Glu Trp  Gln Ala Phe Leu Ile  Lys Glu Ser 
    1055                 1060                 1065             


Lys Glu  Glu Glu Asn Tyr Pro  Tyr Val Val Glu Arg  Glu Ile Glu 
    1070                 1075                 1080             


Gln Tyr  Glu Lys Val Arg Arg  Glu Glu Leu Leu Lys  Glu Val His 
    1085                 1090                 1095             


Leu Ile  Glu Glu Tyr Ile Leu  Glu Lys Val Lys Asp  Lys Glu Ile 
    1100                 1105                 1110             


Leu Lys  Lys Gly Asp Asn Gln  Asn Phe Lys Tyr Tyr  Ile Leu Asn 
    1115                 1120                 1125             


Gly Leu  Leu Lys Gln Leu Lys  Asn Glu Asp Val Glu  Ser Tyr Lys 
    1130                 1135                 1140             


Val Phe  Asn Leu Asn Thr Glu  Pro Glu Asp Val Asn  Ile Asn Gln 
    1145                 1150                 1155             


Leu Lys  Gln Glu Ala Thr Asp  Leu Glu Gln Lys Ala  Phe Val Leu 
    1160                 1165                 1170             


Thr Tyr  Ile Arg Asn Lys Phe  Ala His Asn Gln Leu  Pro Lys Lys 
    1175                 1180                 1185             


Glu Phe  Trp Asp Tyr Cys Gln  Glu Lys Tyr Gly Lys  Ile Glu Lys 
    1190                 1195                 1200             


Glu Lys  Thr Tyr Ala Glu Tyr  Phe Ala Glu Val Phe  Lys Lys Glu 
    1205                 1210                 1215             


Lys Glu  Ala Leu Ile Lys 
    1220                 


<210> 697
<211> 948
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 697
Met Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn Lys Lys His 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Ser 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Ile 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Gly Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro Leu Met Phe 
                325                 330                 335     


Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu Thr Val 
            340                 345                 350         


Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg Ile Asn 
        355                 360                 365             


Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro Leu Gly 
    370                 375                 380                 


Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln Pro Asp 
385                 390                 395                 400 


Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala Glu Thr 
                405                 410                 415     


Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser Pro Lys 
            420                 425                 430         


Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu Ala Asp 
        435                 440                 445             


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu Phe Trp 
465                 470                 475                 480 


Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
                485                 490                 495     


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
            500                 505                 510         


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
        515                 520                 525             


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
    530                 535                 540                 


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
545                 550                 555                 560 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
                565                 570                 575     


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
            580                 585                 590         


Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
        595                 600                 605             


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Lys 
    610                 615                 620                 


Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser Tyr Lys 
625                 630                 635                 640 


Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His Tyr Glu Tyr 
                645                 650                 655     


Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg Leu Glu 
            660                 665                 670         


Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp 
        675                 680                 685             


Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met 
    690                 695                 700                 


Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu 
705                 710                 715                 720 


Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val 
                725                 730                 735     


Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met 
            740                 745                 750         


Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln 
        755                 760                 765             


Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu His Thr 
    770                 775                 780                 


Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys 
                805                 810                 815     


His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln 
            820                 825                 830         


Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu Glu Lys 
        835                 840                 845             


Leu Leu Asn Lys His Thr Ser Leu Ser Ser Leu Glu Asn Glu Phe Arg 
    850                 855                 860                 


Ala Leu Leu Glu Glu Trp Lys Lys Glu Tyr Ala Ala Ser Ser Met Val 
865                 870                 875                 880 


Thr Asp Glu His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala Phe Cys 
                885                 890                 895     


His Asn Gln Tyr Pro Phe Tyr Lys Glu Ala Leu His Ala Pro Ile Pro 
            900                 905                 910         


Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly Leu Gly 
        915                 920                 925             


Ile Ala Glu Ala Leu Leu Lys Val Leu Arg Glu Tyr Cys Glu Ile Val 
    930                 935                 940                 


Lys Ser Gln Ile 
945             


<210> 698
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 698
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 699
<211> 1106
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 699
Met Glu Lys Pro Leu Pro Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Thr Thr Pro Pro Asn Asp 
        35                  40                  45              


Asp Lys Ile Ala Asp Val Val Cys Gly Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Ala Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly Ser Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Asn Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Glu Leu Ile 
        115                 120                 125             


Lys Ala Leu Lys Thr Leu Val Lys Gln Leu Arg Thr Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Gln Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Lys Phe Asp Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Ser Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Lys Asp 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Ala Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Lys Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Val Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Asp Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Val Gln Asn Gln Pro Ile Glu Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Gln Leu Ile Gln Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Thr Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Arg Glu Arg Tyr Gln Asp Asp His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Pro Tyr Glu Leu Glu Ala Lys Ala Ser Thr Pro Lys Pro Pro Leu Pro 
785                 790                 795                 800 


Lys Lys Arg Glu Tyr Val Leu Arg Ala Glu His Tyr Glu Tyr Trp Gln 
                805                 810                 815     


Gln Asn Lys Pro Gln Ser Pro Thr Glu Leu Gln Arg Leu Glu Leu His 
            820                 825                 830         


Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp Gln His 
        835                 840                 845             


Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met Leu Trp 
    850                 855                 860                 


Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu Lys Leu 
865                 870                 875                 880 


Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val Gln Glu 
                885                 890                 895     


Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met Val Leu 
            900                 905                 910         


Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln Tyr Gln 
        915                 920                 925             


Glu Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu Gln Thr Lys Ala 
    930                 935                 940                 


Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn 
945                 950                 955                 960 


Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys His Pro 
                965                 970                 975     


Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln Ser Leu 
            980                 985                 990         


Arg Val Asp Ala Phe Lys Glu Thr  Leu Ser Leu Glu Glu  Lys Leu Leu 
        995                 1000                 1005             


Asn Lys  His Ala Ser Leu Ser  Ser Leu Glu Asn Glu  Phe Arg Thr 
    1010                 1015                 1020             


Leu Leu  Glu Glu Trp Lys Lys  Lys Tyr Ala Ala Ser  Ser Met Val 
    1025                 1030                 1035             


Thr Asp  Glu His Ile Ala Phe  Ile Ala Ser Val Arg  Asn Ala Phe 
    1040                 1045                 1050             


Cys His  Asn Gln Tyr Pro Phe  Tyr Lys Glu Thr Leu  His Ala Pro 
    1055                 1060                 1065             


Ile Leu  Leu Phe Thr Val Ala  Gln Pro Thr Thr Glu  Glu Lys Asp 
    1070                 1075                 1080             


Gly Leu  Gly Ile Ala Glu Ala  Leu Leu Arg Val Leu  Arg Glu Tyr 
    1085                 1090                 1095             


Cys Glu  Ile Val Lys Ser Gln  Ile 
    1100                 1105     


<210> 700
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 700
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 701
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 701
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 702
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 702
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 703
<211> 948
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 703
Met Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn Lys Lys His 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Ser 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Ile 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Gly Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro Leu Met Phe 
                325                 330                 335     


Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu Thr Val 
            340                 345                 350         


Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg Ile Asn 
        355                 360                 365             


Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro Leu Gly 
    370                 375                 380                 


Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln Pro Asp 
385                 390                 395                 400 


Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala Glu Thr 
                405                 410                 415     


Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser Pro Lys 
            420                 425                 430         


Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu Ala Asp 
        435                 440                 445             


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu Phe Trp 
465                 470                 475                 480 


Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
                485                 490                 495     


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
            500                 505                 510         


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
        515                 520                 525             


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
    530                 535                 540                 


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
545                 550                 555                 560 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
                565                 570                 575     


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
            580                 585                 590         


Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
        595                 600                 605             


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Lys 
    610                 615                 620                 


Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser Tyr Lys 
625                 630                 635                 640 


Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His Tyr Glu Tyr 
                645                 650                 655     


Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg Leu Glu 
            660                 665                 670         


Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp 
        675                 680                 685             


Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met 
    690                 695                 700                 


Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu 
705                 710                 715                 720 


Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val 
                725                 730                 735     


Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met 
            740                 745                 750         


Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln 
        755                 760                 765             


Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu His Thr 
    770                 775                 780                 


Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys 
                805                 810                 815     


His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln 
            820                 825                 830         


Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu Glu Lys 
        835                 840                 845             


Leu Leu Asn Lys His Thr Ser Leu Ser Ser Leu Glu Asn Glu Phe Arg 
    850                 855                 860                 


Ala Leu Leu Glu Glu Trp Lys Lys Glu Tyr Ala Ala Ser Ser Met Val 
865                 870                 875                 880 


Thr Asp Glu His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala Phe Cys 
                885                 890                 895     


His Asn Gln Tyr Pro Phe Tyr Lys Glu Ala Leu His Ala Pro Ile Pro 
            900                 905                 910         


Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly Leu Gly 
        915                 920                 925             


Ile Ala Glu Ala Leu Leu Lys Val Leu Arg Glu Tyr Cys Glu Ile Val 
    930                 935                 940                 


Lys Ser Gln Ile 
945             


<210> 704
<211> 1008
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 704
Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210> 705
<211> 1175
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 705
Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Phe Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Lys His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Arg Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Ser Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Ala  Lys Trp Pro Glu Leu  His Glu Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Pro Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Arg Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210> 706
<211> 1008
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 706
Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210> 707
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 707
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Ala Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 708
<211> 1106
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 708
Met Glu Lys Pro Leu Pro Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Thr Thr Pro Pro Asn Asp 
        35                  40                  45              


Asp Lys Ile Ala Asp Val Val Cys Gly Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Ala Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly Ser Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Asn Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Glu Leu Ile 
        115                 120                 125             


Lys Ala Leu Lys Thr Leu Val Lys Gln Leu Arg Thr Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Gln Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Lys Phe Asp Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Ser Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Lys Asp 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Ala Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Lys Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Val Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Asp Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Val Gln Asn Gln Pro Ile Glu Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Gln Leu Ile Gln Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Thr Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Arg Glu Arg Tyr Gln Asp Asp His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Pro Tyr Glu Leu Glu Ala Lys Ala Ser Thr Pro Lys Pro Pro Leu Pro 
785                 790                 795                 800 


Lys Lys Arg Glu Tyr Val Leu Arg Ala Glu His Tyr Glu Tyr Trp Gln 
                805                 810                 815     


Gln Asn Lys Pro Gln Ser Pro Thr Glu Leu Gln Arg Leu Glu Leu His 
            820                 825                 830         


Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp Gln His 
        835                 840                 845             


Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met Leu Trp 
    850                 855                 860                 


Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu Lys Leu 
865                 870                 875                 880 


Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val Gln Glu 
                885                 890                 895     


Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met Val Leu 
            900                 905                 910         


Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln Tyr Gln 
        915                 920                 925             


Glu Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu Gln Thr Lys Ala 
    930                 935                 940                 


Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn 
945                 950                 955                 960 


Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys His Pro 
                965                 970                 975     


Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln Ser Leu 
            980                 985                 990         


Arg Val Asp Ala Phe Lys Glu Thr  Leu Ser Leu Glu Glu  Lys Leu Leu 
        995                 1000                 1005             


Asn Lys  His Ala Ser Leu Ser  Ser Leu Glu Asn Glu  Phe Arg Thr 
    1010                 1015                 1020             


Leu Leu  Glu Glu Trp Lys Lys  Lys Tyr Ala Ala Ser  Ser Met Val 
    1025                 1030                 1035             


Thr Asp  Glu His Ile Ala Phe  Ile Ala Ser Val Arg  Asn Ala Phe 
    1040                 1045                 1050             


Cys His  Asn Gln Tyr Pro Phe  Tyr Lys Glu Thr Leu  His Ala Pro 
    1055                 1060                 1065             


Ile Leu  Leu Phe Thr Val Ala  Gln Pro Thr Thr Glu  Glu Lys Asp 
    1070                 1075                 1080             


Gly Leu  Gly Ile Ala Glu Ala  Leu Leu Arg Val Leu  Arg Glu Tyr 
    1085                 1090                 1095             


Cys Glu  Ile Val Lys Ser Gln  Ile 
    1100                 1105     


<210> 709
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 709
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 710
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 710
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 711
<211> 948
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 711
Met Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn Lys Lys His 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Ser 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Ile 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Gly Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro Leu Met Phe 
                325                 330                 335     


Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu Thr Val 
            340                 345                 350         


Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg Ile Asn 
        355                 360                 365             


Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro Leu Gly 
    370                 375                 380                 


Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln Pro Asp 
385                 390                 395                 400 


Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala Glu Thr 
                405                 410                 415     


Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser Pro Lys 
            420                 425                 430         


Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu Ala Asp 
        435                 440                 445             


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu Phe Trp 
465                 470                 475                 480 


Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
                485                 490                 495     


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
            500                 505                 510         


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
        515                 520                 525             


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
    530                 535                 540                 


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
545                 550                 555                 560 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
                565                 570                 575     


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
            580                 585                 590         


Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
        595                 600                 605             


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Lys 
    610                 615                 620                 


Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser Tyr Lys 
625                 630                 635                 640 


Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His Tyr Glu Tyr 
                645                 650                 655     


Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg Leu Glu 
            660                 665                 670         


Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp 
        675                 680                 685             


Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met 
    690                 695                 700                 


Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu 
705                 710                 715                 720 


Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val 
                725                 730                 735     


Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met 
            740                 745                 750         


Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln 
        755                 760                 765             


Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu His Thr 
    770                 775                 780                 


Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys 
                805                 810                 815     


His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln 
            820                 825                 830         


Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu Glu Lys 
        835                 840                 845             


Leu Leu Asn Lys His Thr Ser Leu Ser Ser Leu Glu Asn Glu Phe Arg 
    850                 855                 860                 


Ala Leu Leu Glu Glu Trp Lys Lys Glu Tyr Ala Ala Ser Ser Met Val 
865                 870                 875                 880 


Thr Asp Glu His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala Phe Cys 
                885                 890                 895     


His Asn Gln Tyr Pro Phe Tyr Lys Glu Ala Leu His Ala Pro Ile Pro 
            900                 905                 910         


Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly Leu Gly 
        915                 920                 925             


Ile Ala Glu Ala Leu Leu Lys Val Leu Arg Glu Tyr Cys Glu Ile Val 
    930                 935                 940                 


Lys Ser Gln Ile 
945             


<210> 712
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 712
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 713
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 713
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 714
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 714
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 715
<211> 1008
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 715
Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210> 716
<211> 948
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 716
Met Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn Lys Lys His 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Ser 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Ile 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Gly Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro Leu Met Phe 
                325                 330                 335     


Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu Thr Val 
            340                 345                 350         


Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg Ile Asn 
        355                 360                 365             


Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro Leu Gly 
    370                 375                 380                 


Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln Pro Asp 
385                 390                 395                 400 


Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala Glu Thr 
                405                 410                 415     


Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser Pro Lys 
            420                 425                 430         


Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu Ala Asp 
        435                 440                 445             


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu Phe Trp 
465                 470                 475                 480 


Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
                485                 490                 495     


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
            500                 505                 510         


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
        515                 520                 525             


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
    530                 535                 540                 


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
545                 550                 555                 560 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
                565                 570                 575     


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
            580                 585                 590         


Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
        595                 600                 605             


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Lys 
    610                 615                 620                 


Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser Tyr Lys 
625                 630                 635                 640 


Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His Tyr Glu Tyr 
                645                 650                 655     


Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg Leu Glu 
            660                 665                 670         


Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp 
        675                 680                 685             


Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met 
    690                 695                 700                 


Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu 
705                 710                 715                 720 


Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val 
                725                 730                 735     


Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met 
            740                 745                 750         


Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln 
        755                 760                 765             


Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu His Thr 
    770                 775                 780                 


Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys 
                805                 810                 815     


His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln 
            820                 825                 830         


Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu Glu Lys 
        835                 840                 845             


Leu Leu Asn Lys His Thr Ser Leu Ser Ser Leu Glu Asn Glu Phe Arg 
    850                 855                 860                 


Ala Leu Leu Glu Glu Trp Lys Lys Glu Tyr Ala Ala Ser Ser Met Val 
865                 870                 875                 880 


Thr Asp Glu His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala Phe Cys 
                885                 890                 895     


His Asn Gln Tyr Pro Phe Tyr Lys Glu Ala Leu His Ala Pro Ile Pro 
            900                 905                 910         


Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly Leu Gly 
        915                 920                 925             


Ile Ala Glu Ala Leu Leu Lys Val Leu Arg Glu Tyr Cys Glu Ile Val 
    930                 935                 940                 


Lys Ser Gln Ile 
945             


<210> 717
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 717
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 718
<211> 1131
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 718
Met Thr Asn Thr Pro Lys Arg Arg Thr Leu His Arg His Pro Ser Tyr 
1               5                   10                  15      


Phe Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Met Ile Met 
            20                  25                  30          


Glu His Leu Ser Thr Lys Tyr Asp Met Glu Asp Lys Asn Thr Leu Asp 
        35                  40                  45              


Glu Ala Gln Leu Pro Asn Ala Lys Leu Phe Gly Cys Leu Lys Lys Arg 
    50                  55                  60                  


Tyr Gly Lys Pro Asp Val Thr Glu Gly Val Ser Arg Asp Leu Arg Arg 
65                  70                  75                  80  


Tyr Phe Pro Phe Leu Asn Tyr Pro Leu Phe Leu His Leu Glu Lys Gln 
                85                  90                  95      


Gln Asn Ala Glu Gln Ala Ala Thr Tyr Asp Ile Asn Pro Glu Asp Ile 
            100                 105                 110         


Glu Phe Thr Leu Lys Gly Phe Phe Arg Leu Leu Asn Gln Met Arg Asn 
        115                 120                 125             


Asn Tyr Ser His Tyr Ile Ser Asn Thr Asp Tyr Gly Lys Phe Asp Lys 
    130                 135                 140                 


Leu Pro Val Gln Asp Ile Tyr Glu Ala Ala Ile Phe Arg Leu Leu Asp 
145                 150                 155                 160 


Arg Gly Lys His Thr Lys Arg Phe Asp Val Phe Glu Ser Lys His Thr 
                165                 170                 175     


Arg His Leu Glu Ser Asn Asn Ser Glu Tyr Arg Pro Arg Ser Leu Ala 
            180                 185                 190         


Asn Ser Pro Asp His Glu Asn Thr Val Ala Phe Val Thr Cys Leu Phe 
        195                 200                 205             


Leu Glu Arg Lys Tyr Ala Phe Pro Phe Leu Ser Arg Leu Asp Cys Phe 
    210                 215                 220                 


Arg Ser Thr Asn Asp Ala Ala Glu Gly Asp Pro Leu Ile Arg Lys Ala 
225                 230                 235                 240 


Ser His Glu Cys Tyr Thr Met Phe Cys Cys Arg Leu Pro Gln Pro Lys 
                245                 250                 255     


Leu Glu Ser Ser Asp Ile Leu Leu Asp Met Val Asn Glu Leu Gly Arg 
            260                 265                 270         


Cys Pro Ser Ala Leu Tyr Asn Leu Leu Ser Glu Glu Asp Gln Ala Arg 
        275                 280                 285             


Phe His Ile Lys Arg Glu Glu Ile Thr Gly Phe Glu Glu Asp Pro Asp 
    290                 295                 300                 


Glu Glu Leu Glu Gln Glu Ile Val Leu Lys Arg His Ser Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Asp Thr Glu Ala Phe Gln Thr 
                325                 330                 335     


Leu Arg Phe Asp Val Tyr Leu Gly Arg Trp Arg Thr Lys Pro Val Tyr 
            340                 345                 350         


Lys Lys Arg Ile Tyr Gly Gln Glu Arg Asp Arg Val Leu Thr Gln Ser 
        355                 360                 365             


Ile Arg Thr Phe Thr Arg Leu Ser Arg Leu Leu Pro Ile Tyr Glu Asn 
    370                 375                 380                 


Val Lys His Asp Ala Val Arg Gln Asn Glu Glu Asp Gly Lys Leu Val 
385                 390                 395                 400 


Asn Pro Asp Val Thr Ser Gln Phe His Lys Ser Trp Ile Gln Ile Glu 
                405                 410                 415     


Ser Asp Asp Arg Ala Phe Leu Ser Asp Arg Ile Glu His Phe Ser Pro 
            420                 425                 430         


His Tyr Asn Phe Gly Asp Gln Val Ile Gly Leu Lys Phe Ile Asn Pro 
        435                 440                 445             


Asp Arg Tyr Ala Ala Ile Gln Asn Val Phe Pro Lys Leu Pro Gly Glu 
    450                 455                 460                 


Glu Lys Lys Asp Lys Asp Ala Lys Leu Val Asn Glu Thr Ala Asp Ala 
465                 470                 475                 480 


Ile Ile Ser Thr His Glu Ile Arg Ser Leu Phe Leu Tyr His Tyr Leu 
                485                 490                 495     


Ser Lys Lys Pro Ile Ser Ala Gly Asp Glu Arg Arg Phe Ile Gln Val 
            500                 505                 510         


Asp Thr Glu Thr Phe Ile Lys Gln Tyr Ile Asp Thr Ile Lys Leu Phe 
        515                 520                 525             


Phe Glu Asp Ile Lys Ser Gly Glu Leu Gln Pro Ile Ala Asp Pro Pro 
    530                 535                 540                 


Asn Tyr Gln Lys Asn Glu Pro Leu Pro Tyr Val Arg Gly Asp Lys Glu 
545                 550                 555                 560 


Lys Thr Gln Glu Glu Arg Ala Gln Tyr Arg Glu Arg Gln Lys Glu Ile 
                565                 570                 575     


Lys Glu Arg Arg Lys Glu Leu Asn Thr Leu Leu Gln Asn Arg Tyr Gly 
            580                 585                 590         


Leu Ser Ile Gln Tyr Ile Pro Ser Arg Leu Arg Glu Tyr Leu Leu Gly 
        595                 600                 605             


Tyr Lys Lys Val Pro Tyr Glu Lys Leu Ala Leu Gln Lys Leu Arg Ala 
    610                 615                 620                 


Gln Arg Lys Glu Val Lys Lys Arg Ile Lys Asp Ile Glu Lys Met Arg 
625                 630                 635                 640 


Thr Pro Arg Val Gly Glu Gln Ala Thr Trp Leu Ala Glu Asp Ile Val 
                645                 650                 655     


Phe Leu Thr Pro Pro Lys Met His Thr Pro Glu Arg Lys Thr Thr Lys 
            660                 665                 670         


His Pro Gln Lys Leu Asn Asn Asp Gln Phe Arg Ile Met Gln Ser Ser 
        675                 680                 685             


Leu Ala Tyr Phe Ser Val Asn Lys Lys Ala Ile Lys Lys Phe Phe Gln 
    690                 695                 700                 


Lys Glu Thr Gly Ile Gly Leu Ser Asn Arg Glu Thr Ser His Pro Phe 
705                 710                 715                 720 


Leu Tyr Arg Ile Asp Val Gly Arg Cys Arg Gly Ile Leu Asp Phe Tyr 
                725                 730                 735     


Thr Gly Tyr Leu Lys Tyr Lys Met Asp Trp Leu Asp Asp Ala Ile Lys 
            740                 745                 750         


Lys Val Asp Asn Arg Lys His Gly Lys Lys Glu Ala Lys Lys Tyr Glu 
        755                 760                 765             


Lys Tyr Leu Pro Ser Ser Ile Gln His Lys Thr Pro Leu Glu Leu Asp 
    770                 775                 780                 


Tyr Thr Arg Leu Pro Val Tyr Leu Pro Arg Gly Leu Phe Lys Lys Ala 
785                 790                 795                 800 


Ile Val Lys Ala Leu Ala Ala His Ala Asp Phe Gln Val Glu Pro Glu 
                805                 810                 815     


Glu Asp Asn Val Ile Phe Cys Leu Asp Gln Leu Leu Asp Gly Asp Thr 
            820                 825                 830         


Gln Asp Phe Tyr Asn Trp Gln Arg Tyr Tyr Arg Ser Ala Leu Thr Glu 
        835                 840                 845             


Lys Glu Thr Asp Asn Gln Leu Val Leu Ala His Pro Tyr Ala Glu Gln 
    850                 855                 860                 


Ile Leu Gly Thr Ile Lys Thr Leu Glu Gly Lys Gln Lys Asn Asn Lys 
865                 870                 875                 880 


Leu Gly Asn Lys Ala Lys Gln Lys Ile Lys Asp Glu Leu Ile Asp Leu 
                885                 890                 895     


Lys Arg Ala Lys Arg Arg Leu Leu Asp Arg Glu Gln Tyr Leu Arg Ala 
            900                 905                 910         


Val Gln Ala Glu Asp Arg Ala Leu Trp Leu Met Ile Gln Glu Arg Gln 
        915                 920                 925             


Lys Gln Lys Ala Glu His Glu Glu Ile Ala Phe Asp Gln Leu Asp Leu 
    930                 935                 940                 


Lys Asn Ile Thr Lys Ile Leu Thr Glu Ser Ile Asp Ala Arg Leu Arg 
945                 950                 955                 960 


Ile Pro Asp Thr Lys Val Asp Ile Thr Asp Lys Leu Pro Leu Arg Arg 
                965                 970                 975     


Tyr Gly Asp Leu Arg Arg Val Ala Lys Asp Arg Arg Leu Val Asn Leu 
            980                 985                 990         


Ala Ser Tyr Tyr His Val Ala Gly  Leu Ser Glu Ile Pro  Tyr Asp Leu 
        995                 1000                 1005             


Val Lys  Lys Glu Leu Glu Glu  Tyr Asp Arg Arg Arg  Val Ala Phe 
    1010                 1015                 1020             


Phe Glu  His Val Tyr Gln Phe  Glu Lys Glu Val Tyr  Asp Arg Tyr 
    1025                 1030                 1035             


Ala Ala  Glu Leu Arg Asn Glu  Asn Pro Lys Gly Glu  Ser Thr Tyr 
    1040                 1045                 1050             


Phe Ser  His Trp Glu Tyr Val  Ala Val Ala Val Lys  His Ser Ala 
    1055                 1060                 1065             


Asp Thr  His Phe Asn Glu Leu  Phe Lys Glu Lys Val  Met Gln Leu 
    1070                 1075                 1080             


Arg Asn  Lys Phe His His Asn  Glu Phe Pro Tyr Phe  Asp Trp Leu 
    1085                 1090                 1095             


Leu Pro  Glu Val Glu Lys Ala  Ser Ala Ala Leu Tyr  Ala Asp Arg 
    1100                 1105                 1110             


Val Phe  Asp Val Ala Glu Gly  Tyr Tyr Gln Lys Met  Arg Lys Leu 
    1115                 1120                 1125             


Met Arg  Gln 
    1130     


<210> 719
<211> 1131
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 719
Met Thr Asn Thr Pro Lys Arg Arg Thr Leu His Arg His Pro Ser Tyr 
1               5                   10                  15      


Phe Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Met Ile Met 
            20                  25                  30          


Glu His Leu Ser Thr Lys Tyr Asp Met Glu Asp Lys Asn Thr Leu Asp 
        35                  40                  45              


Glu Ala Gln Leu Pro Asn Ala Lys Leu Phe Gly Cys Leu Lys Lys Arg 
    50                  55                  60                  


Tyr Gly Lys Pro Asp Val Thr Glu Gly Val Ser Arg Asp Leu Arg Arg 
65                  70                  75                  80  


Tyr Phe Pro Phe Leu Asn Tyr Pro Leu Phe Leu His Leu Glu Lys Gln 
                85                  90                  95      


Gln Asn Ala Glu Gln Ala Ala Thr Tyr Asp Ile Asn Pro Glu Asp Ile 
            100                 105                 110         


Glu Phe Thr Leu Lys Gly Phe Phe Arg Leu Leu Asn Gln Met Arg Asn 
        115                 120                 125             


Asn Tyr Ser His Tyr Ile Ser Asn Thr Asp Tyr Gly Lys Phe Asp Lys 
    130                 135                 140                 


Leu Pro Val Gln Asp Ile Tyr Glu Ala Ala Ile Phe Arg Leu Leu Asp 
145                 150                 155                 160 


Arg Gly Lys His Thr Lys Arg Phe Asp Val Phe Glu Ser Lys His Thr 
                165                 170                 175     


Arg His Leu Glu Ser Asn Asn Ser Glu Tyr Arg Pro Arg Ser Leu Ala 
            180                 185                 190         


Asn Ser Pro Asp His Glu Asn Thr Val Ala Phe Val Thr Cys Leu Phe 
        195                 200                 205             


Leu Glu Arg Lys Tyr Ala Phe Pro Phe Leu Ser Arg Leu Asp Cys Phe 
    210                 215                 220                 


Arg Ser Thr Asn Asp Ala Ala Glu Gly Asp Pro Leu Ile Arg Lys Ala 
225                 230                 235                 240 


Ser His Glu Cys Tyr Thr Met Phe Cys Cys Arg Leu Pro Gln Pro Lys 
                245                 250                 255     


Leu Glu Ser Ser Asp Ile Leu Leu Asp Met Val Asn Glu Leu Gly Arg 
            260                 265                 270         


Cys Pro Ser Ala Leu Tyr Asn Leu Leu Ser Glu Glu Asp Gln Ala Arg 
        275                 280                 285             


Phe His Ile Lys Arg Glu Glu Ile Thr Gly Phe Glu Glu Asp Pro Asp 
    290                 295                 300                 


Glu Glu Leu Glu Gln Glu Ile Val Leu Lys Arg His Ser Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Asp Thr Glu Ala Phe Gln Thr 
                325                 330                 335     


Leu Arg Phe Asp Val Tyr Leu Gly Arg Trp Arg Thr Lys Pro Val Tyr 
            340                 345                 350         


Lys Lys Arg Ile Tyr Gly Gln Glu Arg Asp Arg Val Leu Thr Gln Ser 
        355                 360                 365             


Ile Arg Thr Phe Thr Arg Leu Ser Arg Leu Leu Pro Ile Tyr Glu Asn 
    370                 375                 380                 


Val Lys His Asp Ala Val Arg Gln Asn Glu Glu Asp Gly Lys Leu Val 
385                 390                 395                 400 


Asn Pro Asp Val Thr Ser Gln Phe His Lys Ser Trp Ile Gln Ile Glu 
                405                 410                 415     


Ser Asp Asp Arg Ala Phe Leu Ser Asp Arg Ile Glu His Phe Ser Pro 
            420                 425                 430         


His Tyr Asn Phe Gly Asp Gln Val Ile Gly Leu Lys Phe Ile Asn Pro 
        435                 440                 445             


Asp Arg Tyr Ala Ala Ile Gln Asn Val Phe Pro Lys Leu Pro Gly Glu 
    450                 455                 460                 


Glu Lys Lys Asp Lys Asp Ala Lys Leu Val Asn Glu Thr Ala Asp Ala 
465                 470                 475                 480 


Ile Ile Ser Thr His Glu Ile Arg Ser Leu Phe Leu Tyr His Tyr Leu 
                485                 490                 495     


Ser Lys Lys Pro Ile Ser Ala Gly Asp Glu Arg Arg Phe Ile Gln Val 
            500                 505                 510         


Asp Thr Glu Thr Phe Ile Lys Gln Tyr Ile Asp Thr Ile Lys Leu Phe 
        515                 520                 525             


Phe Glu Asp Ile Lys Ser Gly Glu Leu Gln Pro Ile Ala Asp Pro Pro 
    530                 535                 540                 


Asn Tyr Gln Lys Asn Glu Pro Leu Pro Tyr Val Arg Gly Asp Lys Glu 
545                 550                 555                 560 


Lys Thr Gln Glu Glu Arg Ala Gln Tyr Arg Glu Arg Gln Lys Glu Ile 
                565                 570                 575     


Lys Glu Arg Arg Lys Glu Leu Asn Thr Leu Leu Gln Asn Arg Tyr Gly 
            580                 585                 590         


Leu Ser Ile Gln Tyr Ile Pro Ser Arg Leu Arg Glu Tyr Leu Leu Gly 
        595                 600                 605             


Tyr Lys Lys Val Pro Tyr Glu Lys Leu Ala Leu Gln Lys Leu Arg Ala 
    610                 615                 620                 


Gln Arg Lys Glu Val Lys Lys Arg Ile Lys Asp Ile Glu Lys Met Arg 
625                 630                 635                 640 


Thr Pro Arg Val Gly Glu Gln Ala Thr Trp Leu Ala Glu Asp Ile Val 
                645                 650                 655     


Phe Leu Thr Pro Pro Lys Met His Thr Pro Glu Arg Lys Thr Thr Lys 
            660                 665                 670         


His Pro Gln Lys Leu Asn Asn Asp Gln Phe Arg Ile Met Gln Ser Ser 
        675                 680                 685             


Leu Ala Tyr Phe Ser Val Asn Lys Lys Ala Ile Lys Lys Phe Phe Gln 
    690                 695                 700                 


Lys Glu Thr Gly Ile Gly Leu Ser Asn Arg Glu Thr Ser His Pro Phe 
705                 710                 715                 720 


Leu Tyr Arg Ile Asp Val Gly Arg Cys Arg Gly Ile Leu Asp Phe Tyr 
                725                 730                 735     


Thr Gly Tyr Leu Lys Tyr Lys Met Asp Trp Leu Asp Asp Ala Ile Lys 
            740                 745                 750         


Lys Val Asp Asn Arg Lys His Gly Lys Lys Glu Ala Lys Lys Tyr Glu 
        755                 760                 765             


Lys Tyr Leu Pro Ser Ser Ile Gln His Lys Thr Pro Leu Glu Leu Asp 
    770                 775                 780                 


Tyr Thr Arg Leu Pro Val Tyr Leu Pro Arg Gly Leu Phe Lys Lys Ala 
785                 790                 795                 800 


Ile Val Lys Ala Leu Ala Ala His Ala Asp Phe Gln Val Glu Pro Glu 
                805                 810                 815     


Glu Asp Asn Val Ile Phe Cys Leu Asp Gln Leu Leu Asp Gly Asp Thr 
            820                 825                 830         


Gln Asp Phe Tyr Asn Trp Gln Arg Tyr Tyr Arg Ser Ala Leu Thr Glu 
        835                 840                 845             


Lys Glu Thr Asp Asn Gln Leu Val Leu Ala His Pro Tyr Ala Glu Gln 
    850                 855                 860                 


Ile Leu Gly Thr Ile Lys Thr Leu Glu Gly Lys Gln Lys Asn Asn Lys 
865                 870                 875                 880 


Leu Gly Asn Lys Ala Lys Gln Lys Ile Lys Asp Glu Leu Ile Asp Leu 
                885                 890                 895     


Lys Arg Ala Lys Arg Arg Leu Leu Asp Arg Glu Gln Tyr Leu Arg Ala 
            900                 905                 910         


Val Gln Ala Glu Asp Arg Ala Leu Trp Leu Met Ile Gln Glu Arg Gln 
        915                 920                 925             


Lys Gln Lys Ala Glu His Glu Glu Ile Ala Phe Asp Gln Leu Asp Leu 
    930                 935                 940                 


Lys Asn Ile Thr Lys Ile Leu Thr Glu Ser Ile Asp Ala Arg Leu Arg 
945                 950                 955                 960 


Ile Pro Asp Thr Lys Val Asp Ile Thr Asp Lys Leu Pro Leu Arg Arg 
                965                 970                 975     


Tyr Gly Asp Leu Arg Arg Val Ala Lys Asp Arg Arg Leu Val Asn Leu 
            980                 985                 990         


Ala Ser Tyr Tyr His Val Ala Gly  Leu Ser Glu Ile Pro  Tyr Asp Leu 
        995                 1000                 1005             


Val Lys  Lys Glu Leu Glu Glu  Tyr Asp Arg Arg Arg  Val Ala Phe 
    1010                 1015                 1020             


Phe Glu  His Val Tyr Gln Phe  Glu Lys Glu Val Tyr  Asp Arg Tyr 
    1025                 1030                 1035             


Ala Ala  Glu Leu Arg Asn Glu  Asn Pro Lys Gly Glu  Ser Thr Tyr 
    1040                 1045                 1050             


Phe Ser  His Trp Glu Tyr Val  Ala Val Ala Val Lys  His Ser Ala 
    1055                 1060                 1065             


Asp Thr  His Phe Asn Glu Leu  Phe Lys Glu Lys Val  Met Gln Leu 
    1070                 1075                 1080             


Arg Asn  Lys Phe His His Asn  Glu Phe Pro Tyr Phe  Asp Trp Leu 
    1085                 1090                 1095             


Leu Pro  Glu Val Glu Lys Ala  Ser Ala Ala Leu Tyr  Ala Asp Arg 
    1100                 1105                 1110             


Val Phe  Asp Val Ala Glu Gly  Tyr Tyr Gln Lys Met  Arg Lys Leu 
    1115                 1120                 1125             


Met Arg  Gln 
    1130     


<210> 720
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 720
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 721
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 721
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 722
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 722
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 723
<211> 1115
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 723
Met Glu Ser Ile Lys Asn Ser Gln Lys Ser Thr Gly Lys Thr Leu Gln 
1               5                   10                  15      


Lys Asp Pro Pro Tyr Phe Gly Leu Tyr Leu Asn Met Ala Leu Leu Asn 
            20                  25                  30          


Val Arg Lys Val Glu Asn His Ile Arg Lys Trp Leu Gly Asp Val Ala 
        35                  40                  45              


Leu Leu Pro Glu Lys Ser Gly Phe His Ser Leu Leu Thr Thr Asp Asn 
    50                  55                  60                  


Leu Ser Ser Ala Lys Trp Thr Arg Phe Tyr Tyr Lys Ser Arg Lys Phe 
65                  70                  75                  80  


Leu Pro Phe Leu Glu Met Phe Asp Ser Asp Lys Lys Ser Tyr Glu Asn 
                85                  90                  95      


Arg Arg Glu Thr Thr Glu Cys Leu Asp Thr Ile Asp Arg Gln Lys Ile 
            100                 105                 110         


Ser Ser Leu Leu Lys Glu Val Tyr Gly Lys Leu Gln Asp Ile Arg Asn 
        115                 120                 125             


Ala Phe Ser His Tyr His Ile Asp Asp Gln Ser Val Lys His Thr Ala 
    130                 135                 140                 


Leu Ile Ile Ser Ser Glu Met His Arg Phe Ile Glu Asn Ala Tyr Ser 
145                 150                 155                 160 


Phe Ala Leu Gln Lys Thr Arg Ala Arg Phe Thr Gly Val Phe Val Glu 
                165                 170                 175     


Thr Asp Phe Leu Gln Ala Glu Glu Lys Gly Asp Asn Lys Lys Phe Phe 
            180                 185                 190         


Ala Ile Gly Gly Asn Glu Gly Ile Lys Leu Lys Asp Asn Ala Leu Ile 
        195                 200                 205             


Phe Leu Ile Cys Leu Phe Leu Asp Arg Glu Glu Ala Phe Lys Phe Leu 
    210                 215                 220                 


Ser Arg Ala Thr Gly Phe Lys Ser Thr Lys Glu Lys Gly Phe Leu Ala 
225                 230                 235                 240 


Val Arg Glu Thr Phe Cys Ala Leu Cys Cys Arg Gln Pro His Glu Arg 
                245                 250                 255     


Leu Leu Ser Val Asn Pro Arg Glu Ala Leu Leu Met Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Asn Arg Cys Pro Asp Ile Leu Phe Glu Met Leu Asp Glu Lys 
        275                 280                 285             


Asp Gln Lys Ser Phe Leu Pro Leu Leu Gly Glu Glu Glu Gln Ala His 
    290                 295                 300                 


Ile Leu Glu Asn Ser Leu Asn Asp Glu Leu Cys Glu Ala Ile Asp Asp 
305                 310                 315                 320 


Pro Phe Glu Met Ile Ala Ser Leu Ser Lys Arg Val Arg Tyr Lys Asn 
                325                 330                 335     


Arg Phe Pro Tyr Leu Met Leu Arg Tyr Ile Glu Glu Lys Asn Leu Leu 
            340                 345                 350         


Pro Phe Ile Arg Phe Arg Ile Asp Leu Gly Cys Leu Glu Leu Ala Ser 
        355                 360                 365             


Tyr Pro Lys Lys Met Gly Glu Glu Asn Asn Tyr Glu Arg Ser Val Thr 
    370                 375                 380                 


Asp His Ala Met Ala Phe Gly Arg Leu Thr Asp Phe His Asn Glu Asp 
385                 390                 395                 400 


Ala Val Leu Gln Gln Ile Thr Lys Gly Ile Thr Asp Glu Val Arg Phe 
                405                 410                 415     


Ser Leu Tyr Ala Pro Arg Tyr Ala Ile Tyr Asn Asn Lys Ile Gly Phe 
            420                 425                 430         


Val Arg Thr Gly Gly Ser Asp Lys Ile Ser Phe Pro Thr Leu Lys Lys 
        435                 440                 445             


Lys Gly Gly Glu Gly His Cys Val Ala Tyr Thr Leu Gln Asn Thr Lys 
    450                 455                 460                 


Ser Phe Gly Phe Ile Ser Ile Tyr Asp Leu Arg Lys Ile Leu Leu Leu 
465                 470                 475                 480 


Ser Phe Leu Asp Lys Asp Lys Ala Lys Asn Ile Val Ser Gly Leu Leu 
                485                 490                 495     


Glu Gln Cys Glu Lys His Trp Lys Asp Leu Ser Glu Asn Leu Phe Asp 
            500                 505                 510         


Ala Ile Arg Thr Glu Leu Gln Lys Glu Phe Pro Val Pro Leu Ile Arg 
        515                 520                 525             


Tyr Thr Leu Pro Arg Ser Lys Gly Gly Lys Leu Val Ser Ser Lys Leu 
    530                 535                 540                 


Ala Asp Lys Gln Glu Lys Tyr Glu Ser Glu Phe Glu Arg Arg Lys Glu 
545                 550                 555                 560 


Lys Leu Thr Glu Ile Leu Ser Glu Lys Asp Phe Asp Leu Ser Gln Ile 
                565                 570                 575     


Pro Arg Arg Met Ile Asp Glu Trp Leu Asn Val Leu Pro Thr Ser Arg 
            580                 585                 590         


Glu Lys Lys Leu Lys Gly Tyr Val Glu Thr Leu Lys Leu Asp Cys Arg 
        595                 600                 605             


Glu Arg Leu Arg Val Phe Glu Lys Arg Glu Lys Gly Glu His Pro Val 
    610                 615                 620                 


Pro Pro Arg Ile Gly Glu Met Ala Thr Asp Leu Ala Lys Asp Ile Ile 
625                 630                 635                 640 


Arg Met Val Ile Asp Gln Gly Val Lys Gln Arg Ile Thr Ser Ala Tyr 
                645                 650                 655     


Tyr Ser Glu Ile Gln Arg Cys Leu Ala Gln Tyr Ala Gly Asp Asp Asn 
            660                 665                 670         


Arg Arg His Leu Asp Ser Ile Ile Arg Glu Leu Arg Leu Lys Asp Thr 
        675                 680                 685             


Lys Asn Gly His Pro Phe Leu Gly Lys Val Leu Arg Pro Gly Leu Gly 
    690                 695                 700                 


His Thr Glu Lys Leu Tyr Gln Arg Tyr Phe Glu Glu Lys Lys Glu Trp 
705                 710                 715                 720 


Leu Glu Ala Thr Phe Tyr Pro Ala Ala Ser Pro Lys Arg Val Pro Arg 
                725                 730                 735     


Phe Val Asn Pro Pro Thr Gly Lys Gln Lys Glu Leu Pro Leu Ile Ile 
            740                 745                 750         


Arg Asn Leu Met Lys Glu Arg Pro Glu Trp Arg Asp Trp Lys Gln Arg 
        755                 760                 765             


Lys Asn Ser His Pro Ile Asp Leu Pro Ser Gln Leu Phe Glu Asn Glu 
    770                 775                 780                 


Ile Cys Arg Leu Leu Lys Asp Lys Ile Gly Lys Glu Pro Ser Gly Lys 
785                 790                 795                 800 


Leu Lys Trp Asn Glu Met Phe Lys Leu Tyr Trp Asp Lys Glu Phe Pro 
                805                 810                 815     


Asn Gly Met Gln Arg Phe Tyr Arg Cys Lys Arg Arg Val Glu Val Phe 
            820                 825                 830         


Asp Lys Val Val Glu Tyr Glu Tyr Ser Glu Glu Gly Gly Asn Tyr Lys 
        835                 840                 845             


Lys Tyr Tyr Glu Ala Leu Ile Asp Glu Val Val Arg Gln Lys Ile Ser 
    850                 855                 860                 


Ser Ser Lys Glu Lys Ser Lys Leu Gln Val Glu Asp Leu Thr Leu Ser 
865                 870                 875                 880 


Val Arg Arg Val Phe Lys Arg Ala Ile Asn Glu Lys Glu Tyr Gln Leu 
                885                 890                 895     


Arg Leu Leu Cys Glu Asp Asp Arg Leu Leu Phe Met Ala Val Arg Asp 
            900                 905                 910         


Leu Tyr Asp Trp Lys Glu Ala Gln Leu Asp Leu Asp Lys Ile Asp Asn 
        915                 920                 925             


Met Leu Gly Glu Pro Val Ser Val Ser Gln Val Ile Gln Leu Glu Gly 
    930                 935                 940                 


Gly Gln Pro Asp Ala Val Ile Lys Ala Glu Cys Lys Leu Lys Asp Val 
945                 950                 955                 960 


Ser Lys Leu Met Arg Tyr Cys Tyr Asp Gly Arg Val Lys Gly Leu Met 
                965                 970                 975     


Pro Tyr Phe Ala Asn His Glu Ala Thr Gln Glu Gln Val Glu Met Glu 
            980                 985                 990         


Leu Arg His Tyr Glu Asp His Arg  Arg Arg Val Phe Asn  Trp Val Phe 
        995                 1000                 1005             


Ala Leu  Glu Lys Ser Val Leu  Lys Asn Glu Lys Leu  Arg Arg Phe 
    1010                 1015                 1020             


Tyr Glu  Glu Ser Gln Gly Gly  Cys Glu His Arg Arg  Cys Ile Asp 
    1025                 1030                 1035             


Ala Leu  Arg Lys Ala Ser Leu  Val Ser Glu Glu Glu  Tyr Glu Phe 
    1040                 1045                 1050             


Leu Val  His Ile Arg Asn Lys  Ser Ala His Asn Gln  Phe Pro Asp 
    1055                 1060                 1065             


Leu Glu  Ile Gly Lys Leu Pro  Pro Asn Val Thr Ser  Gly Phe Cys 
    1070                 1075                 1080             


Glu Cys  Ile Trp Ser Lys Tyr  Lys Ala Ile Ile Cys  Arg Ile Ile 
    1085                 1090                 1095             


Pro Phe  Ile Asp Pro Glu Arg  Arg Phe Phe Gly Lys  Leu Leu Glu 
    1100                 1105                 1110             


Gln Lys  
    1115 


<210> 724
<211> 1099
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 724
Met Glu Lys Pro Leu Pro Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Thr Thr Pro Pro Asn Asp 
        35                  40                  45              


Asp Lys Ile Ala Asp Val Val Cys Gly Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Ala Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly Ser Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Lys Glu Lys Glu Asn Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro 
        115                 120                 125             


Ser Glu Leu Ile Lys Val Leu Lys Thr Ile Val Lys Gln Leu Arg Thr 
    130                 135                 140                 


Leu Arg Asn Tyr Tyr Ser His His Ser His Lys Lys Pro Asp Thr Glu 
145                 150                 155                 160 


Lys Asp Ile Phe Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg 
                165                 170                 175     


Met Val Lys Glu Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg 
            180                 185                 190         


Asp Phe Ala His Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro 
        195                 200                 205             


Asp Phe Asn Arg Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser 
    210                 215                 220                 


Gly Leu Leu Phe Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr 
225                 230                 235                 240 


Trp Met Leu Lys Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg 
                245                 250                 255     


Glu Lys Met Thr Thr Glu Val Phe Cys Arg Ser His Ile Leu Leu Pro 
            260                 265                 270         


Lys Leu Arg Leu Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp 
        275                 280                 285             


Met Leu Ser Glu Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu 
    290                 295                 300                 


Ser Glu Glu Asn Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu 
305                 310                 315                 320 


Asp Glu Ile Glu Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg 
                325                 330                 335     


His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn 
            340                 345                 350         


Glu Ser Phe Lys Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His 
        355                 360                 365             


Tyr Cys Ile Tyr Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His 
    370                 375                 380                 


Leu Thr Arg Thr Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu 
385                 390                 395                 400 


Ile Asn Arg Pro Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr 
                405                 410                 415     


Lys Glu Thr Ser Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr 
            420                 425                 430         


His Ile Thr Asp Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu 
        435                 440                 445             


Leu Tyr Pro Ser Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys 
    450                 455                 460                 


Tyr Pro Tyr Asn Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His 
465                 470                 475                 480 


Glu Leu Leu Pro Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu 
                485                 490                 495     


Asp Leu Leu Lys Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp 
            500                 505                 510         


Phe Glu Glu Glu Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn 
        515                 520                 525             


Gln Gly Arg Leu Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu 
    530                 535                 540                 


Leu Gln Asn Lys Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile 
545                 550                 555                 560 


Glu Lys Leu Ile Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr 
                565                 570                 575     


Lys Leu Lys Ser Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile 
            580                 585                 590         


Lys Thr Gly Val Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe 
        595                 600                 605             


Gln Pro Val Ala Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys 
    610                 615                 620                 


Ala Asn Ser Thr Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr 
625                 630                 635                 640 


Gly Gly Glu Lys Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu 
                645                 650                 655     


Ile Gly Asn Thr Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys 
            660                 665                 670         


Ala Cys Arg Asn Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg 
        675                 680                 685             


Glu Lys Phe Leu Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln 
    690                 695                 700                 


Tyr Cys Leu Leu Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val 
705                 710                 715                 720 


Lys Gly Trp Glu Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr 
                725                 730                 735     


Glu Ala Ile Arg Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro 
            740                 745                 750         


Ile Arg Lys Glu Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg 
        755                 760                 765             


Ala Ile Thr Leu Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser 
    770                 775                 780                 


Phe Tyr Asn Leu Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys 
785                 790                 795                 800 


Arg Glu Glu His Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro 
                805                 810                 815     


Thr Glu Ser Gln Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp 
            820                 825                 830         


Tyr Leu Leu Tyr Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu 
        835                 840                 845             


Tyr Arg Asn Gln Asp Ile Met Leu Trp Leu Met Thr Leu Glu Leu Thr 
    850                 855                 860                 


Lys Asn His Phe Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu 
865                 870                 875                 880 


Glu Asn Leu Ala Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro 
                885                 890                 895     


Leu Asn Gln Thr Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala 
            900                 905                 910         


Thr Ala Phe Gly Glu Val Gln Tyr Gln Glu Thr Pro Ile Arg Thr Val 
        915                 920                 925             


Tyr Ile Arg Glu Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys 
    930                 935                 940                 


Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys 
945                 950                 955                 960 


Glu Glu Asn Asp Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg 
                965                 970                 975     


Arg Glu Leu Glu Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu 
            980                 985                 990         


Thr Leu Asp Leu Glu Glu Lys Leu  Leu Lys Lys His Thr  Ser Leu Ser 
        995                 1000                 1005             


Ser Leu  Glu Asn Lys Phe Arg  Ile Leu Leu Glu Glu  Trp Lys Lys 
    1010                 1015                 1020             


Glu Tyr  Ala Ala Ser Ser Met  Val Thr Asp Glu His  Ile Ala Phe 
    1025                 1030                 1035             


Ile Ala  Ser Val Arg Asn Ala  Phe Cys His Asn Gln  Tyr Pro Phe 
    1040                 1045                 1050             


Tyr Glu  Glu Ala Leu His Ala  Pro Ile Pro Leu Phe  Thr Val Ala 
    1055                 1060                 1065             


Gln Gln  Thr Thr Glu Glu Lys  Asp Gly Leu Gly Ile  Ala Glu Ala 
    1070                 1075                 1080             


Leu Leu  Arg Val Leu Arg Glu  Tyr Cys Glu Ile Val  Lys Ser Gln 
    1085                 1090                 1095             


Ile 
    


<210> 725
<211> 948
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 725
Met Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn Lys Lys His 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Ser 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Ile 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Gly Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro Leu Met Phe 
                325                 330                 335     


Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu Thr Val 
            340                 345                 350         


Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg Ile Asn 
        355                 360                 365             


Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro Leu Gly 
    370                 375                 380                 


Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln Pro Asp 
385                 390                 395                 400 


Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala Glu Thr 
                405                 410                 415     


Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser Pro Lys 
            420                 425                 430         


Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu Ala Asp 
        435                 440                 445             


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu Phe Trp 
465                 470                 475                 480 


Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
                485                 490                 495     


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
            500                 505                 510         


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
        515                 520                 525             


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
    530                 535                 540                 


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
545                 550                 555                 560 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
                565                 570                 575     


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
            580                 585                 590         


Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
        595                 600                 605             


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Lys 
    610                 615                 620                 


Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser Tyr Lys 
625                 630                 635                 640 


Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His Tyr Glu Tyr 
                645                 650                 655     


Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg Leu Glu 
            660                 665                 670         


Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp 
        675                 680                 685             


Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met 
    690                 695                 700                 


Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu 
705                 710                 715                 720 


Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val 
                725                 730                 735     


Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met 
            740                 745                 750         


Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln 
        755                 760                 765             


Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu His Thr 
    770                 775                 780                 


Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys 
                805                 810                 815     


His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln 
            820                 825                 830         


Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu Glu Lys 
        835                 840                 845             


Leu Leu Asn Lys His Thr Ser Leu Ser Ser Leu Glu Asn Glu Phe Arg 
    850                 855                 860                 


Ala Leu Leu Glu Glu Trp Lys Lys Glu Tyr Ala Ala Ser Ser Met Val 
865                 870                 875                 880 


Thr Asp Glu His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala Phe Cys 
                885                 890                 895     


His Asn Gln Tyr Pro Phe Tyr Lys Glu Ala Leu His Ala Pro Ile Pro 
            900                 905                 910         


Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly Leu Gly 
        915                 920                 925             


Ile Ala Glu Ala Leu Leu Lys Val Leu Arg Glu Tyr Cys Glu Ile Val 
    930                 935                 940                 


Lys Ser Gln Ile 
945             


<210> 726
<211> 1099
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 726
Met Glu Lys Pro Leu Pro Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Thr Thr Pro Pro Asn Asp 
        35                  40                  45              


Asp Lys Ile Ala Asp Val Val Cys Gly Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Ala Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly Ser Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Lys Glu Lys Glu Asn Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro 
        115                 120                 125             


Ser Glu Leu Ile Lys Val Leu Lys Thr Ile Val Lys Gln Leu Arg Thr 
    130                 135                 140                 


Leu Arg Asn Tyr Tyr Ser His His Ser His Lys Lys Pro Asp Thr Glu 
145                 150                 155                 160 


Lys Asp Ile Phe Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg 
                165                 170                 175     


Met Val Lys Glu Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg 
            180                 185                 190         


Asp Phe Ala His Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro 
        195                 200                 205             


Asp Phe Asn Arg Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser 
    210                 215                 220                 


Gly Leu Leu Phe Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr 
225                 230                 235                 240 


Trp Met Leu Lys Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg 
                245                 250                 255     


Glu Lys Met Thr Thr Glu Val Phe Cys Arg Ser His Ile Leu Leu Pro 
            260                 265                 270         


Lys Leu Arg Leu Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp 
        275                 280                 285             


Met Leu Ser Glu Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu 
    290                 295                 300                 


Ser Glu Glu Asn Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu 
305                 310                 315                 320 


Asp Glu Ile Glu Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg 
                325                 330                 335     


His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn 
            340                 345                 350         


Glu Ser Phe Lys Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His 
        355                 360                 365             


Tyr Cys Ile Tyr Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His 
    370                 375                 380                 


Leu Thr Arg Thr Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu 
385                 390                 395                 400 


Ile Asn Arg Pro Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr 
                405                 410                 415     


Lys Glu Thr Ser Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr 
            420                 425                 430         


His Ile Thr Asp Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu 
        435                 440                 445             


Leu Tyr Pro Ser Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys 
    450                 455                 460                 


Tyr Pro Tyr Asn Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His 
465                 470                 475                 480 


Glu Leu Leu Pro Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu 
                485                 490                 495     


Asp Leu Leu Lys Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp 
            500                 505                 510         


Phe Glu Glu Glu Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn 
        515                 520                 525             


Gln Gly Arg Leu Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu 
    530                 535                 540                 


Leu Gln Asn Lys Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile 
545                 550                 555                 560 


Glu Lys Leu Ile Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr 
                565                 570                 575     


Lys Leu Lys Ser Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile 
            580                 585                 590         


Lys Thr Gly Val Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe 
        595                 600                 605             


Gln Pro Val Ala Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys 
    610                 615                 620                 


Ala Asn Ser Thr Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr 
625                 630                 635                 640 


Gly Gly Glu Lys Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu 
                645                 650                 655     


Ile Gly Asn Thr Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys 
            660                 665                 670         


Ala Cys Arg Asn Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg 
        675                 680                 685             


Glu Lys Phe Leu Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln 
    690                 695                 700                 


Tyr Cys Leu Leu Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val 
705                 710                 715                 720 


Lys Gly Trp Glu Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr 
                725                 730                 735     


Glu Ala Ile Arg Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro 
            740                 745                 750         


Ile Arg Lys Glu Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg 
        755                 760                 765             


Ala Ile Thr Leu Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser 
    770                 775                 780                 


Phe Tyr Asn Leu Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys 
785                 790                 795                 800 


Arg Glu Glu His Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro 
                805                 810                 815     


Thr Glu Ser Gln Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp 
            820                 825                 830         


Tyr Leu Leu Tyr Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu 
        835                 840                 845             


Tyr Arg Asn Gln Asp Ile Met Leu Trp Leu Met Thr Leu Glu Leu Thr 
    850                 855                 860                 


Lys Asn His Phe Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu 
865                 870                 875                 880 


Glu Asn Leu Ala Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro 
                885                 890                 895     


Leu Asn Gln Thr Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala 
            900                 905                 910         


Thr Ala Phe Gly Glu Val Gln Tyr Gln Glu Thr Pro Ile Arg Thr Val 
        915                 920                 925             


Tyr Ile Arg Glu Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys 
    930                 935                 940                 


Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys 
945                 950                 955                 960 


Glu Glu Asn Asp Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg 
                965                 970                 975     


Arg Glu Leu Glu Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu 
            980                 985                 990         


Thr Leu Asp Leu Glu Glu Lys Leu  Leu Lys Lys His Thr  Ser Leu Ser 
        995                 1000                 1005             


Ser Leu  Glu Asn Lys Phe Arg  Ile Leu Leu Glu Glu  Trp Lys Lys 
    1010                 1015                 1020             


Glu Tyr  Ala Ala Ser Ser Met  Val Thr Asp Glu His  Ile Ala Phe 
    1025                 1030                 1035             


Ile Ala  Ser Val Arg Asn Ala  Phe Cys His Asn Gln  Tyr Pro Phe 
    1040                 1045                 1050             


Tyr Glu  Glu Ala Leu His Ala  Pro Ile Pro Leu Phe  Thr Val Ala 
    1055                 1060                 1065             


Gln Gln  Thr Thr Glu Glu Lys  Asp Gly Leu Gly Ile  Ala Glu Ala 
    1070                 1075                 1080             


Leu Leu  Arg Val Leu Arg Glu  Tyr Cys Glu Ile Val  Lys Ser Gln 
    1085                 1090                 1095             


Ile 
    


<210> 727
<211> 1003
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 727
Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210> 728
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 728
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Asp Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 729
<211> 1106
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 729
Met Glu Lys Pro Leu Pro Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Thr Thr Pro Pro Asn Asp 
        35                  40                  45              


Asp Lys Ile Ala Asp Val Val Cys Gly Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Ala Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly Ser Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Asn Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Glu Leu Ile 
        115                 120                 125             


Lys Ala Leu Lys Thr Leu Val Lys Gln Leu Arg Thr Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Gln Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Lys Phe Asp Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Ser Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Lys Asp 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Ala Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Lys Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Val Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Asp Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Val Gln Asn Gln Pro Ile Glu Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Gln Leu Ile Gln Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Thr Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Arg Glu Arg Tyr Gln Asp Asp His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Pro Tyr Glu Leu Glu Ala Lys Ala Ser Thr Pro Lys Pro Pro Leu Pro 
785                 790                 795                 800 


Lys Lys Arg Glu Tyr Val Leu Arg Ala Glu His Tyr Glu Tyr Trp Gln 
                805                 810                 815     


Gln Asn Lys Pro Gln Ser Pro Thr Glu Leu Gln Arg Leu Glu Leu His 
            820                 825                 830         


Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp Gln His 
        835                 840                 845             


Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met Leu Trp 
    850                 855                 860                 


Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu Lys Leu 
865                 870                 875                 880 


Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val Gln Glu 
                885                 890                 895     


Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met Val Leu 
            900                 905                 910         


Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln Tyr Gln 
        915                 920                 925             


Glu Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu Gln Thr Lys Ala 
    930                 935                 940                 


Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn 
945                 950                 955                 960 


Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys His Pro 
                965                 970                 975     


Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln Ser Leu 
            980                 985                 990         


Arg Val Asp Ala Phe Lys Glu Thr  Leu Ser Leu Glu Glu  Lys Leu Leu 
        995                 1000                 1005             


Asn Lys  His Ala Ser Leu Ser  Ser Leu Glu Asn Glu  Phe Arg Thr 
    1010                 1015                 1020             


Leu Leu  Glu Glu Trp Lys Lys  Lys Tyr Ala Ala Ser  Ser Met Val 
    1025                 1030                 1035             


Thr Asp  Glu His Ile Ala Phe  Ile Ala Ser Val Arg  Asn Ala Phe 
    1040                 1045                 1050             


Cys His  Asn Gln Tyr Pro Phe  Tyr Lys Glu Thr Leu  His Ala Pro 
    1055                 1060                 1065             


Ile Leu  Leu Phe Thr Val Ala  Gln Pro Thr Thr Glu  Glu Lys Asp 
    1070                 1075                 1080             


Gly Leu  Gly Ile Ala Glu Ala  Leu Leu Arg Val Leu  Arg Glu Tyr 
    1085                 1090                 1095             


Cys Glu  Ile Val Lys Ser Gln  Ile 
    1100                 1105     


<210> 730
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 730
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 731
<211> 1095
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas13 sequence"

<400> 731
Met Glu Lys Pro Leu Leu Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Lys Thr Pro Ser Asn Asp 
        35                  40                  45              


Asp Lys Ile Val Asp Val Val Cys Glu Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Thr Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly His Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Ser Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Lys Leu Ile 
        115                 120                 125             


Glu Ala Leu Glu Ile Leu Val Asn Gln Leu His Ser Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Asn Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Ile Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Gly Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val 
            580                 585                 590         


Leu Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala 
        595                 600                 605             


Tyr Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Phe Trp Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys 
625                 630                 635                 640 


Asn Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr 
                645                 650                 655     


Asn Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn 
            660                 665                 670         


Leu Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu 
        675                 680                 685             


Glu Ala Ile Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu 
    690                 695                 700                 


Leu Lys Ile Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu 
705                 710                 715                 720 


Gln Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg 
                725                 730                 735     


Glu Thr Leu Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu 
            740                 745                 750         


Ile Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu 
        755                 760                 765             


Tyr Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu 
    770                 775                 780                 


Ser Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His 
785                 790                 795                 800 


Tyr Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln 
                805                 810                 815     


Arg Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr 
            820                 825                 830         


Lys Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln 
        835                 840                 845             


Asp Val Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe 
    850                 855                 860                 


Lys Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala 
865                 870                 875                 880 


Val Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr 
                885                 890                 895     


Leu Pro Met Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly 
            900                 905                 910         


Glu Val Gln Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu 
        915                 920                 925             


Glu His Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys 
    930                 935                 940                 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp 
945                 950                 955                 960 


Thr Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu 
                965                 970                 975     


Ile Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu 
            980                 985                 990         


Glu Glu Lys Leu Leu Asn Lys His  Thr Ser Leu Ser Ser  Leu Glu Asn 
        995                 1000                 1005             


Glu Phe  Arg Ala Leu Leu Glu  Glu Trp Lys Lys Glu  Tyr Ala Ala 
    1010                 1015                 1020             


Ser Ser  Met Val Thr Asp Glu  His Ile Ala Phe Ile  Ala Ser Val 
    1025                 1030                 1035             


Arg Asn  Ala Phe Cys His Asn  Gln Tyr Pro Phe Tyr  Lys Glu Ala 
    1040                 1045                 1050             


Leu His  Ala Pro Ile Pro Leu  Phe Thr Val Ala Gln  Pro Thr Thr 
    1055                 1060                 1065             


Glu Glu  Lys Asp Gly Leu Gly  Ile Ala Glu Ala Leu  Leu Lys Val 
    1070                 1075                 1080             


Leu Arg  Glu Tyr Cys Glu Ile  Val Lys Ser Gln Ile  
    1085                 1090                 1095 


<210> 732
<211> 1335
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12a sequence"

<400> 732
Met Lys Ser Leu Ala Gln Phe Gln Asn Leu Tyr Ala Leu Gln Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Glu Gly His Thr Arg Glu Thr Phe Asn 
            20                  25                  30          


Arg Trp Leu Glu Glu Ile Glu Lys Glu Gln Ala Ser Glu Asn Glu Asn 
        35                  40                  45              


Ile Val Tyr Gln Asp Leu Leu Arg Ala Lys Lys Tyr Glu Lys Ile Lys 
    50                  55                  60                  


Ile Ile Leu Asp Glu Tyr His Lys Asp Phe Ile Glu Gln Ala Leu Ala 
65                  70                  75                  80  


Tyr Ala Asn Leu Thr Glu Leu Glu Lys Tyr Glu Glu Leu Tyr Arg Lys 
                85                  90                  95      


Ser Asn Arg Thr Ser Glu Glu Glu Glu Glu Phe Glu Asn Thr Lys Glu 
            100                 105                 110         


Ser Leu Arg Lys Gln Ile Ala Asn Ile Phe Ile Lys Asn Pro Asn Lys 
        115                 120                 125             


Thr Val Gln Glu Arg Trp Lys Phe Leu Phe Ser Lys Lys Leu Ile Gln 
    130                 135                 140                 


Asn Glu Leu Ile Val Trp Val Lys Gly Asn Tyr Glu Leu Leu Ser Glu 
145                 150                 155                 160 


Lys Leu Lys Asn Glu Phe Pro Asp Glu Ser Ser Ile Ile Ser Thr Ile 
                165                 170                 175     


Glu Asp Phe Lys Tyr Phe Thr Thr Tyr Phe Arg Asn Tyr His Glu Asn 
            180                 185                 190         


Arg Lys Asn Leu Tyr Ser Asn Glu Asp Lys Phe Ser Thr Ile Ala His 
        195                 200                 205             


Arg Leu Ile His Glu Asn Leu Pro Lys Phe Ile Asp Asn Ile Ala Ile 
    210                 215                 220                 


Tyr Gln Lys Ala Lys Ala Val Leu Asn Ile Asn Glu Val Glu Lys Glu 
225                 230                 235                 240 


Leu Gly Leu Pro Glu Asp Thr Leu Asp Lys Ile Phe Ser Leu Asp Phe 
                245                 250                 255     


Phe Ser Lys Ala Leu Thr Gln Lys Gly Ile Asp Gln Tyr Asn Tyr Phe 
            260                 265                 270         


Leu Gly Gly Lys Thr Glu Asn Glu Val Lys Lys Ile Lys Gly Leu Asn 
        275                 280                 285             


Glu Phe Ile Asn Leu Tyr Asn Gln Gln Gln Gln Asp Lys Asn Gln Arg 
    290                 295                 300                 


Leu Pro Phe Leu Lys Val Leu Tyr Lys Leu Pro Leu Phe Glu Arg Thr 
305                 310                 315                 320 


Ser Thr Ser Phe Arg Phe Glu Pro Ile Glu Asn Asp Arg Asp Leu Ile 
                325                 330                 335     


Glu Arg Ile Gly Lys Phe Tyr Tyr Asn Asp Leu Lys Gln Tyr Arg Asp 
            340                 345                 350         


Asp Ser Gln Gly Asp Thr Thr Asp Ile Leu Ser Gly Ile Asn Thr Leu 
        355                 360                 365             


Leu Arg His Val His Asp Tyr Arg Asp Gly Leu Tyr Val Asn Gly Gly 
    370                 375                 380                 


Ile Thr Leu Thr Gln Ile Ser Gln Lys Ile Phe Gly Ser Trp Ser Tyr 
385                 390                 395                 400 


Ile Asn Asn Ala Leu Ala Tyr Phe Tyr Asp Thr Tyr Ile Asp Ala Ser 
                405                 410                 415     


Gly Val Asp His Gln Gly Glu Arg Lys Pro Lys Lys Gln Lys Gln Ile 
            420                 425                 430         


Gln Glu Lys Thr Lys Trp Leu Lys Gln Lys Gln Phe Pro Val Ile Leu 
        435                 440                 445             


Val Glu Lys Ala Leu Ser Glu Tyr Lys Ser Ile Glu Thr Asn Glu Asp 
    450                 455                 460                 


Leu Lys Thr Arg Ile Ser Asp Thr Thr Leu Cys Asp Phe Phe Lys Arg 
465                 470                 475                 480 


Cys Gly Asn Asp Asp Asn Gly Gln Asp Leu Phe Asp Arg Ile Glu Ala 
                485                 490                 495     


Arg Leu Arg Glu Lys Asn Glu Glu Gly Tyr Ser Leu Glu Asp Leu Leu 
            500                 505                 510         


Lys Lys Glu Phe Thr Thr Glu Arg Lys Leu Met Gln Asp Lys Thr Lys 
        515                 520                 525             


Thr Leu Leu Ile Lys Asn Phe Leu Asp Val Ile Gln Gly Asp Lys Asp 
    530                 535                 540                 


Asp Ile Thr Ala Gly Leu Leu His Phe Val Lys Cys Leu Ile Pro Arg 
545                 550                 555                 560 


Thr Glu Ile Ser Glu Lys Asn Glu Leu Phe Tyr Ser Gly Met Glu Lys 
                565                 570                 575     


Tyr Leu Asn Ile Leu Ser Glu Val Thr Pro Leu Tyr Asn Lys Ala Arg 
            580                 585                 590         


Asn Tyr Leu Thr Gln Lys Pro Tyr Ser Ile Glu Lys Val Lys Leu Asn 
        595                 600                 605             


Phe Glu Asn Ser Thr Leu Leu Asp Gly Trp Asp Glu Asn Glu Glu Ser 
    610                 615                 620                 


Asp Asn Ser Cys Val Leu Leu Arg Lys Arg Gly Tyr Tyr Tyr Leu Gly 
625                 630                 635                 640 


Ile Met Asn Lys Lys His Asn Met Ile Phe Asp Arg Lys Ile Tyr Pro 
                645                 650                 655     


Lys Ala Thr Glu Gly Glu Ala Tyr Tyr Glu Lys Met Ile Tyr Lys Leu 
            660                 665                 670         


Leu Pro Gly Ala Tyr Lys Met Leu Pro Lys Val Phe Phe Ser Glu Lys 
        675                 680                 685             


Asn Ile Asp Tyr Phe Lys Pro Ser Glu Glu Ile Leu Arg Ile Arg Asn 
    690                 695                 700                 


Thr Ala Ser Tyr Ser Lys Asn Gly Gln Pro Gln Glu Gly Tyr Gln Lys 
705                 710                 715                 720 


Ala Ser Phe Ser Ile Glu Asp Cys Arg Lys Tyr Ile Asp Phe Phe Lys 
                725                 730                 735     


Lys Cys Ile Ala Asn His Trp Asp Trp Gln Lys Phe Asn Phe Asn Phe 
            740                 745                 750         


Ser Pro Thr Glu Tyr Tyr Gln Ser Ile Asp Glu Phe Tyr Arg Glu Ile 
        755                 760                 765             


Glu Arg Gln Gly Tyr Lys Ile Asp Phe Val Lys Ile Pro Glu Ser Tyr 
    770                 775                 780                 


Ile Asn Gln Leu Ile Lys Glu Asn Lys Leu Tyr Leu Phe Lys Ile Tyr 
785                 790                 795                 800 


Asn Lys Asp Phe Ser Glu Lys Lys Lys Ser Lys Gly Lys Asp Asn Leu 
                805                 810                 815     


His Thr Leu Tyr Trp Lys Met Leu Phe Asp Glu Lys Asn Leu Lys Asp 
            820                 825                 830         


Val Val Leu Lys Leu Asn Gly Glu Ala Glu Val Phe Phe Arg Gln Lys 
        835                 840                 845             


Ser Ile Leu Tyr Asn Glu Glu Ile Trp Asn Lys Gly His His Tyr Ser 
    850                 855                 860                 


Glu Leu Lys Asp Arg Phe Ser Tyr Pro Ile Ile Ser Asn Lys Arg Tyr 
865                 870                 875                 880 


Ala Glu Asp Lys Phe Phe Leu His Val Pro Ile Thr Leu Asn Phe Lys 
                885                 890                 895     


Ala Asp Gly Ile Asn Asn Val Asn Asn Met Val Asn Glu Phe Ile Lys 
            900                 905                 910         


Asp Asn Arg Asp Ile His Ile Ile Gly Ile Asp Arg Gly Glu Arg His 
        915                 920                 925             


Leu Leu Tyr Val Ser Val Ile Asn Gln Lys Gly Asp Ile Val Glu Gln 
    930                 935                 940                 


Cys Ser Leu Asn Glu Ile Val Thr Glu Tyr Asn Gly Lys Ile Phe Lys 
945                 950                 955                 960 


Lys Asn Tyr His Glu Glu Leu Asp Asn Leu Glu Lys Glu Arg Asp Arg 
                965                 970                 975     


Ala Arg Lys Asp Trp Gln Thr Ile Ala Asn Ile Lys Glu Leu Lys Glu 
            980                 985                 990         


Gly Tyr Leu Ser His Val Ile His  Lys Ile Ser Lys Leu  Ile Leu Lys 
        995                 1000                 1005             


Tyr Asn  Ala Ile Val Val Met  Glu Asp Leu Asn Ser  Gly Phe Lys 
    1010                 1015                 1020             


Arg Gly  Arg Gln Lys Val Glu  Lys Gln Val Tyr Gln  Asn Phe Glu 
    1025                 1030                 1035             


Lys Gln  Leu Ile Glu Lys Leu  Asn Tyr Leu Val Leu  Lys Glu Ser 
    1040                 1045                 1050             


Asn Val  Asp Glu Pro Gly Gly  Val Leu Arg Ala Tyr  Gln Leu Ala 
    1055                 1060                 1065             


Asn Lys  Phe Glu Thr Phe Lys  Lys Leu Gly Lys Gln  Ser Gly Ile 
    1070                 1075                 1080             


Ile Phe  Tyr Val Pro Ala Ala  Tyr Thr Ser Ala Ile  Asp Pro Val 
    1085                 1090                 1095             


Thr Gly  Tyr Ile Gln Tyr Leu  Tyr Pro Leu Lys Gln  Ala Asp Ser 
    1100                 1105                 1110             


Val Glu  Lys Ala Arg Lys Phe  Tyr Ser Gln Phe Lys  Arg Ile Ser 
    1115                 1120                 1125             


Tyr Asn  Pro His Lys Gln Trp  Phe Glu Phe Ser Phe  Asp Tyr Asn 
    1130                 1135                 1140             


Asp Phe  Asn Ile Ile Tyr His  Gly Lys Ser Ser Trp  Thr Ile Cys 
    1145                 1150                 1155             


Thr Thr  Asn Thr Glu Arg Tyr  Met Trp Asn Arg Leu  Leu Asn Asn 
    1160                 1165                 1170             


Gly His  Gly Gly Glu Glu Leu  Val Tyr Val Thr Asn  Glu Leu Glu 
    1175                 1180                 1185             


Leu Leu  Phe Gly Glu Tyr Asn  Ile Ile Tyr Gly Asp  Gly Lys Asp 
    1190                 1195                 1200             


Ile Lys  Gln Gln Ile Thr Asp  Val Gln Asp Ile Asp  Val Asp Arg 
    1205                 1210                 1215             


Thr Ala  Lys Gln Phe Tyr Lys  Arg Ile Asn Glu Leu  Leu Asn Leu 
    1220                 1225                 1230             


Thr Leu  Lys Leu Arg His Asn  Asn Gly Lys Lys Gly  Ala Asp Glu 
    1235                 1240                 1245             


Glu Asp  Tyr Ile Leu Ser Pro  Val Glu Pro Tyr Phe  Asp Ser Arg 
    1250                 1255                 1260             


Phe Glu  Ser Arg Lys Pro Ser  Met Gln Gln Thr Leu  Pro Ile Asn 
    1265                 1270                 1275             


Ala Asp  Ala Asn Gly Ala Phe  Asn Ile Ala Arg Lys  Gly Leu Leu 
    1280                 1285                 1290             


Leu Leu  Glu Arg Leu Asn Gln  Leu Gly Val Glu Glu  Phe Glu Lys 
    1295                 1300                 1305             


Thr Lys  Lys Ser Asn Asn Lys  Lys Thr Gln Trp Leu  Pro His Glu 
    1310                 1315                 1320             


Leu Trp  Val Glu Tyr Ala Gln  Asn His Thr Arg Lys  
    1325                 1330                 1335 


<210> 733
<211> 1273
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12a sequence"

<400> 733
Met Gln Asp Lys Thr Gly Trp Ser Ser Phe Thr Asn Lys Tyr Ser Leu 
1               5                   10                  15      


Ser Lys Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Asn Thr Gln Lys 
            20                  25                  30          


Met Leu Glu Asp Asp Gly Val Phe Gln Lys Asp Arg Glu Arg Gln Glu 
        35                  40                  45              


Asn Tyr Lys Lys Val Lys Pro Phe Met Asp Lys Leu His Arg Glu Phe 
    50                  55                  60                  


Ile Lys Glu Ala Leu Asn Asn Leu Lys Leu Glu Gly Leu Thr Glu Tyr 
65                  70                  75                  80  


Phe Glu Ile Phe Lys Lys Phe Arg Lys Asp Lys Asn Asn Lys Glu Leu 
                85                  90                  95      


Lys Asn Ala Glu Lys Lys Leu Arg Gln Ile Ile Gly Arg Cys Tyr Thr 
            100                 105                 110         


Glu Thr Ala Gln Ile Trp Val Glu Lys Tyr Lys Glu Phe Gly Phe Lys 
        115                 120                 125             


Lys Lys Asn Ile Gly Phe Leu Phe Glu Glu Gly Val Phe Glu Leu Met 
    130                 135                 140                 


Lys Leu Lys Tyr Gly Asn Asp Glu Ala Ser Gln Ile Glu Lys Asn Gly 
145                 150                 155                 160 


Glu Val Leu Ser Ile Phe Asp Gly Trp Lys Gly Phe Leu Gly Tyr Phe 
                165                 170                 175     


Lys Lys Phe Phe Glu Thr Arg Asn Asn Phe Tyr Lys Asp Asp Gly Thr 
            180                 185                 190         


Ser Thr Ala Val Ser Thr Arg Ile Ile Asn Glu Asn Leu Lys Ile Tyr 
        195                 200                 205             


Leu Asp Asn Leu Ile Lys Tyr Asn Lys Ile Lys Asp Lys Val Asp Phe 
    210                 215                 220                 


Lys Glu Ala Asp Ile Leu Gln Glu Asn Lys Leu Asn Leu Ser Asp Phe 
225                 230                 235                 240 


Phe Asn Val Glu Ser Tyr Ala Lys Tyr Ser Leu Gln Lys Gly Ile Asp 
                245                 250                 255     


Tyr Tyr Asn Glu Ile Leu Gly Gly Lys Thr Leu Lys Asn Gly Thr Lys 
            260                 265                 270         


Leu Lys Gly Leu Asn Glu Val Ile Asn Glu Tyr Lys Gln Lys Asn Lys 
        275                 280                 285             


Ser Gly Glu Leu Ser Lys Phe Lys Met Leu Lys Lys Gln Ile Leu Gly 
    290                 295                 300                 


Glu Gly Glu Asp Arg Thr Leu Phe Glu Glu Ile Glu Asn Glu Asp Glu 
305                 310                 315                 320 


Leu Lys Asp Val Leu Lys Asp Phe Phe Tyr Asn Ala Asp Pro Lys Ile 
                325                 330                 335     


Thr Leu Phe Lys Thr Leu Leu Glu Asp Phe Phe Ser Asn Thr Glu Lys 
            340                 345                 350         


Tyr Lys Asp Glu Leu Asp Lys Ile Tyr Phe Asn Thr Val Ala Ile Asn 
        355                 360                 365             


Gly Ile Leu His Arg Trp Val Asp Asp Ser Gly Val Phe Gln Lys Tyr 
    370                 375                 380                 


Leu Phe Glu Val Leu Lys Ser Asn Lys Leu Val Lys Ser Asn His Tyr 
385                 390                 395                 400 


Asp Lys Lys Glu Asp Ser Tyr Lys Phe Pro Asp Phe Ile Ser Phe Glu 
                405                 410                 415     


His Ile Lys Val Ala Leu Glu Asn Cys Glu Arg Asp Gly Leu Lys Asp 
            420                 425                 430         


Lys Phe Trp Lys Glu Lys Tyr Tyr Thr Lys Glu Cys Leu Thr Glu Asn 
        435                 440                 445             


Gly Leu Ala Asn Leu Trp Gln Glu Phe Leu Glu Ile Tyr Lys Cys Glu 
    450                 455                 460                 


Phe Lys Lys Leu Tyr Asp Tyr Lys Thr Asp Asp Asn Asp Cys Tyr Leu 
465                 470                 475                 480 


Gln Tyr Arg Asp Asn Tyr Lys Lys Tyr Ile Leu Asp Ala Asn Phe Asn 
                485                 490                 495     


Pro Lys Glu Lys Ser Ala Lys Asp Ile Ile Lys Asp Tyr Leu Asp Ser 
            500                 505                 510         


Val Leu Ser Ile Tyr Gln Leu Ala Lys Tyr Phe Ala Leu Glu Lys Lys 
        515                 520                 525             


Lys Val Trp Thr Thr Asp Tyr Glu Thr Gly Asp Phe Tyr Tyr Glu Tyr 
    530                 535                 540                 


Ile Lys Phe Tyr Glu Asp Thr Tyr Glu Gln Ile Ile Lys Pro Tyr Asn 
545                 550                 555                 560 


Leu Val Arg Asn Tyr Leu Thr Arg Lys Pro Ile Asn Thr Ala Lys Lys 
                565                 570                 575     


Trp Lys Leu Asn Phe Asp Asn Ala Tyr Leu Ala Ser Gly Trp Asp Lys 
            580                 585                 590         


Asp Lys Glu Val Ser Asn Leu Thr Val Ile Leu Arg Arg Asp Glu Gln 
        595                 600                 605             


Tyr Tyr Leu Ala Ile Met Lys Lys Gly Lys Asn Lys Ile Phe Glu Lys 
    610                 615                 620                 


Lys Phe Ser Cys Gly Glu Phe Glu Lys Met Glu Tyr Lys Gln Ile Ala 
625                 630                 635                 640 


Glu Ala Ser Ser Asp Ile His Asn Leu Val Leu Met Asn Asp Gly Ser 
                645                 650                 655     


Cys Arg Arg Cys Ile Lys Met His Asp Lys Arg Lys Tyr Trp Pro Leu 
            660                 665                 670         


Asp Ile Ser Ile Ile Lys Glu Lys Lys Ser Tyr Ala Lys Glu Asn Phe 
        675                 680                 685             


Val Arg Arg Asp Phe Glu Arg Phe Val Asn Tyr Met Lys Lys Cys Ser 
    690                 695                 700                 


Leu Leu Tyr Trp Lys Glu Tyr Asp Leu Lys Phe Ser Asp Thr Ser Thr 
705                 710                 715                 720 


Tyr Lys Asn Ile Asn Asp Phe Thr Asn Glu Ile Ala Ser Gln Gly Tyr 
                725                 730                 735     


Lys Leu Ser Phe Ser Ala Ile Pro Glu Ser Tyr Ile Asn Glu Lys Asn 
            740                 745                 750         


Asn Asn Gly Glu Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Gly 
        755                 760                 765             


Ile Lys Thr Glu Gly Asn Lys Asn Leu His Thr Met Tyr Trp Glu Ser 
    770                 775                 780                 


Ile Phe Ser Glu Glu Asn Arg Phe Arg Asn Phe Ile Val Lys Leu Asn 
785                 790                 795                 800 


Gly Lys Ala Glu Ile Phe Tyr Arg Pro Lys Ser Glu Gln Val Glu Lys 
                805                 810                 815     


Glu Gln Arg Asn Phe Thr Arg Glu Ile Ile Lys Asn Arg Arg Tyr Thr 
            820                 825                 830         


Glu Asn Lys Ile Tyr Phe His Cys Pro Ile Thr Leu Asn Arg Ile Ser 
        835                 840                 845             


Arg Glu Asn Val Lys Lys Phe Asn Asn Gly Ile Asn Asn Tyr Ile Ala 
    850                 855                 860                 


Thr Asn Pro Asn Ile Asn Ile Leu Gly Val Asp Arg Gly Glu Lys His 
865                 870                 875                 880 


Leu Val Tyr Tyr Ala Ile Val Asp Gln Asp Gly Lys Leu Ile Asp Ala 
                885                 890                 895     


Glu Asp Ala Thr Gly Ser Phe Asn Thr Ile Gly Ser Thr Asp Tyr His 
            900                 905                 910         


Arg Leu Leu Glu Glu Lys Ala Lys Asp Arg Glu Lys Glu Arg Lys Asp 
        915                 920                 925             


Trp Asp Leu Ile Arg Gly Ile Lys Asp Leu Lys Lys Gly Tyr Ile Ser 
    930                 935                 940                 


Leu Val Val Arg Lys Ile Ala Asp Leu Ala Ile Lys Tyr Asn Ala Ile 
945                 950                 955                 960 


Ile Ile Phe Glu Asp Leu Asn Thr Arg Phe Lys Gln Ile Arg Gly Gly 
                965                 970                 975     


Met Glu Lys Ser Val Tyr Gln Gln Leu Glu Lys Ala Leu Ile Asn Lys 
            980                 985                 990         


Leu Ser Phe Leu Val Asn Lys Gly  Glu Lys Asp Pro Glu  Gln Ala Gly 
        995                 1000                 1005             


His Leu  Leu Lys Ala Tyr Gln  Leu Ala Ala Pro Phe  Gln Thr Phe 
    1010                 1015                 1020             


Asp Lys  Met Gly Arg Gln Thr  Gly Ile Ile Phe Tyr  Thr Gln Ala 
    1025                 1030                 1035             


Ser Tyr  Thr Ser Lys Ile Asp  Pro Ile Thr Gly Trp  Arg Pro Asn 
    1040                 1045                 1050             


Leu Tyr  Leu Lys Tyr Arg Asn  Ile Asp Asp Ser Lys  Glu Ser Ile 
    1055                 1060                 1065             


Lys Lys  Phe Lys Ser Ile Leu  Phe Asn Lys Glu Lys  Asn Arg Phe 
    1070                 1075                 1080             


Glu Phe  Thr Tyr Asp Leu Lys  Asp Phe Val Asp Phe  Glu Glu Asp 
    1085                 1090                 1095             


Lys Ile  Pro Glu Lys Thr Glu  Trp Thr Leu Cys Ser  Ser Val Glu 
    1100                 1105                 1110             


Arg His  Lys Trp Asn Arg His  Met Asn Asn Asn Lys  Gly Gly Tyr 
    1115                 1120                 1125             


Glu Val  Tyr Lys Asp Leu Thr  Glu Asn Phe Tyr Lys  Leu Phe Asp 
    1130                 1135                 1140             


Glu Asn  Asn Ile Ser Met Asn  Lys Asp Ile Val Asp  Gln Val Glu 
    1145                 1150                 1155             


Ser Ile  Ser Asn Gly Asn Phe  Phe Arg Gln Phe Ile  Tyr Leu Phe 
    1160                 1165                 1170             


Asn Leu  Val Cys Gln Ile Arg  Asn Thr Asp Glu Lys  Ala Glu Asp 
    1175                 1180                 1185             


Val Asp  Lys Arg Asp Phe Ile  Leu Ser Pro Val Glu  Pro Phe Phe 
    1190                 1195                 1200             


Asp Ser  Arg Arg Ala Lys Asp  Phe Lys Ala Tyr Gly  Asp Asn Leu 
    1205                 1210                 1215             


Pro Lys  Asn Gly Asp Glu Asn  Gly Ala Tyr Asn Ile  Ala Arg Lys 
    1220                 1225                 1230             


Gly Val  Leu Ile Ile Lys Lys  Ile Lys Glu Tyr Tyr  Asn Gln Asn 
    1235                 1240                 1245             


Gly Ser  Cys Asp Lys Leu Gly  Trp Gly Asp Leu Ser  Ile Ser His 
    1250                 1255                 1260             


Lys Glu  Trp Asp Asp Phe Ala  Thr Asn Asn 
    1265                 1270             


<210> 734
<211> 1301
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12a sequence"

<400> 734
Met Asp Ser Tyr Glu Gln Phe Thr Lys Leu Tyr Pro Ile Gln Lys Thr 
1               5                   10                  15      


Ile Arg Phe Glu Leu Lys Pro Gln Gly Arg Thr Lys Glu His Phe Asp 
            20                  25                  30          


Asn Ser Asn Phe Leu Glu Lys Asp Arg Glu Arg Asp Asp Asn Tyr Lys 
        35                  40                  45              


Ile Leu Lys Glu Val Ile Asp Asp Tyr His Arg Glu Phe Ile Asp Glu 
    50                  55                  60                  


Cys Leu Ser Asn Ile Gln Leu Asn Trp Asp Asp Leu Lys Lys Phe Ser 
65                  70                  75                  80  


Glu Glu Tyr Arg Arg Ser Lys Glu Lys Lys Asn Asn Arg Asp Ser Glu 
                85                  90                  95      


Ser Glu Gln Lys Arg Met Ser Thr Thr Ser Glu Thr Arg Ala Ile Asn 
            100                 105                 110         


Lys Lys Asn Leu Glu Ala Glu Gln Lys Arg Met Arg Gly Glu Ile Val 
        115                 120                 125             


Ser Ala Phe Lys Lys Asp Asp Arg Phe Lys His Leu Phe Ser Glu Lys 
    130                 135                 140                 


Leu Phe Ser Ile Leu Leu Lys Asn Gln Ile Tyr Glu Lys Gly Thr Leu 
145                 150                 155                 160 


Glu Glu Ile Glu Ala Phe Asp Cys Phe Asn Lys Phe Ser Gly Tyr Phe 
                165                 170                 175     


Lys Ser Phe His Glu Asn Arg Lys Asn Met Tyr Ser Asp Glu Asp Lys 
            180                 185                 190         


Glu Thr Ala Ile Ser Tyr Arg Ile Ile Asn Glu Asn Phe Pro Lys Leu 
        195                 200                 205             


Leu Asp Asn Phe Glu Lys Tyr Gln Tyr Val Cys Arg Glu Tyr Pro Glu 
    210                 215                 220                 


Gln Ile Arg Glu Ala Glu Ser Thr Leu Ala Glu Ala Gly Cys Tyr Ile 
225                 230                 235                 240 


Lys Met Asp Glu Ile Phe Ser Ile Asp Asn Phe Asn Asn Val Met Met 
                245                 250                 255     


Gln Gly Gly Lys Glu Ser Gly Ile Ser Arg Tyr Asn Leu Ala Ile Gly 
            260                 265                 270         


Gly Ile Val Gln Gly Thr Gly Glu Lys Pro Lys Gly Leu Asn Glu Phe 
        275                 280                 285             


Leu Asn Leu Ala Tyr Gln Asn Glu Pro Asn Gly Arg Lys Lys Ile Arg 
    290                 295                 300                 


Met Glu Pro Leu Tyr Lys Gln Ile Leu Ser Lys Glu Glu Ser Phe Ser 
305                 310                 315                 320 


Tyr Arg Leu Glu Ala Phe Thr Asp Asp Ser Gln Leu Leu Ser Ala Ile 
                325                 330                 335     


Arg Ser Phe Phe Asp Ile Val Glu Lys Asp Lys Asn Gly Asn Ile Phe 
            340                 345                 350         


Asp Arg Ala Val Asn Leu Met Ser Ser Phe Ser Asn Tyr Asp Thr Ser 
        355                 360                 365             


Lys Ile Tyr Ile Arg Lys Ala Tyr Leu Asn Gln Val Ser Lys Glu Ile 
    370                 375                 380                 


Phe Gly Tyr Arg Gly Lys Ser Asp Ser Lys Pro Ala Lys Thr Ala Asp 
385                 390                 395                 400 


Glu Ser Leu Asn Lys Ser Gly Gly Trp Glu Lys Leu Gly Gln Met Leu 
                405                 410                 415     


Arg Asp Tyr Lys Ala Asp Ser Ile Gly Asp Arg Asn Leu Glu Lys Thr 
            420                 425                 430         


Cys Lys Lys Val Asp Lys Trp Leu Asp Ser Asp Glu Phe Thr Leu Ser 
        435                 440                 445             


Asp Ile Leu Gly Ala Ile Ser Leu Ala Gly Ser Asn Glu Thr Phe Glu 
    450                 455                 460                 


Ala Tyr Val Ser Glu Ile Cys Val Ala Arg Arg Asn Ile Asp Lys Glu 
465                 470                 475                 480 


Lys Glu Lys Glu Lys Asn Ile Asn Val Glu Lys Ile Ser Gly Asp Thr 
                485                 490                 495     


Glu Ser Ile Gln Ile Ile Lys Ala Leu Leu Asp Ser Val Gln Glu Phe 
            500                 505                 510         


Phe His Leu Leu Ser Pro Phe Gln Leu His Pro Asn Thr Pro His Asp 
        515                 520                 525             


Trp Thr Phe Tyr Ala Glu Phe Asn Asp Ile Tyr Asp Lys Leu Ser Ala 
    530                 535                 540                 


Ile Thr Pro Leu Tyr Asn Gln Ala Arg Asn His Leu Thr Lys Lys Asn 
545                 550                 555                 560 


Leu Asp Thr Ser Lys Ile Lys Leu Asn Phe Asn Asn Pro Thr Leu Ala 
                565                 570                 575     


Asn Gly Trp Asp Val Asn Lys Glu Tyr Glu Asn Thr Ala Val Ile Leu 
            580                 585                 590         


Ile Arg Asp Gly Lys Tyr Tyr Leu Gly Ile Met Asn Pro Lys Asn Lys 
        595                 600                 605             


Arg Lys Ile Lys Phe Asp Glu Gly Ser Gly Ala Gly Pro Phe Tyr Gln 
    610                 615                 620                 


Lys Met Val Tyr Lys Leu Leu Pro Gly Pro Tyr Arg Met Leu Pro Lys 
625                 630                 635                 640 


Val Phe Phe Ala Lys Lys Asn Ile Asp Tyr Tyr Asn Pro Ser Gln Glu 
                645                 650                 655     


Ile Arg Glu Gly Tyr Lys Ala Gly Lys His Lys Lys Gly Lys Glu Phe 
            660                 665                 670         


Asp Lys Gly Phe Cys His Lys Leu Ile Asp Phe Phe Lys Glu Ser Ile 
        675                 680                 685             


Gln Lys Asn Glu Asn Trp Lys Val Phe Asp Phe Lys Phe Ser Pro Thr 
    690                 695                 700                 


Glu Ser Tyr Asp Asp Ile Ser Glu Phe Tyr Gln Glu Val Glu Lys Gln 
705                 710                 715                 720 


Gly Tyr Arg Met Tyr Phe Val Asn Ile Pro Ser Asp Thr Ile Asp Arg 
                725                 730                 735     


Tyr Val Glu Gly Gly Asp Met Phe Leu Phe Gln Ile Tyr Asn Lys Asp 
            740                 745                 750         


Phe Ala Lys Gly Ala Lys Gly Asn Lys Asp Met His Thr Leu Tyr Trp 
        755                 760                 765             


Asn Ala Val Phe Ser Glu Glu Asn Leu Gln Lys Gly Val Met Lys Leu 
    770                 775                 780                 


Ser Gly Glu Ala Glu Leu Phe Tyr Arg Lys Lys Ser Asp Ile Lys Asp 
785                 790                 795                 800 


Pro Pro His Arg Glu Gly Glu Ile Leu Val Asn Arg Thr Tyr Ile Asp 
                805                 810                 815     


Arg Thr His Val Ser Gly Val Met Gly Glu Gln Asn Thr Val Lys Glu 
            820                 825                 830         


Ser Arg Ile Pro Val Pro Asp Glu Ile His Lys Asn Leu Phe Asp Tyr 
        835                 840                 845             


Tyr Asn His Gly Arg Glu Leu Thr Lys Glu Glu Lys Glu Tyr Cys Asp 
    850                 855                 860                 


Lys Val Gly Ser Phe Lys Ala Tyr Tyr Gly Ile Val Lys Asp Arg Arg 
865                 870                 875                 880 


Tyr Leu Glu Asn Lys Met Tyr Phe His Val Pro Leu Thr Leu Asn Phe 
                885                 890                 895     


Lys Ala Ile Gly Glu Lys Arg Ile Asn Lys Met Ala Ile Glu Lys Phe 
            900                 905                 910         


Leu Thr Asp Glu Asn Ala Cys Ile Ile Gly Ile Asp Arg Gly Glu Arg 
        915                 920                 925             


Asn Leu Leu Tyr Tyr Ser Ile Ile Asp Arg Asn Gly Lys Ile Ile Asp 
    930                 935                 940                 


Gln Lys Ser Leu Asn Val Ile Asp Gly Phe Asp Tyr His Glu Lys Leu 
945                 950                 955                 960 


Ser Gln Arg Gln Thr Glu Arg Glu Val Ala Arg Gln Ser Trp Asn Ser 
                965                 970                 975     


Ile Gly Lys Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ala Lys Ala Val 
            980                 985                 990         


His Glu Ile Ser Lys Met Ala Ile  Lys Tyr Asn Ala Ile  Val Val Leu 
        995                 1000                 1005             


Glu Asp  Leu His Phe Gly Phe  Lys Lys Gly Arg Leu  Lys Val Glu 
    1010                 1015                 1020             


Lys Gln  Ile Tyr Gln Lys Phe  Glu Glu Met Leu Ile  Asn Lys Leu 
    1025                 1030                 1035             


Asn Tyr  Leu Val Phe Lys Asp  Val Ser Asp Ser Ser  Asp Ala Gly 
    1040                 1045                 1050             


Gly Val  Leu Asn Ala Tyr Gln  Leu Thr Ala Pro Leu  Glu Ser Phe 
    1055                 1060                 1065             


Ser Lys  Leu Gly Lys Gln Ser  Gly Ile Leu Phe Tyr  Val Pro Ala 
    1070                 1075                 1080             


Ala Phe  Thr Ser Val Ile Asp  Pro Thr Thr Gly Phe  Val Asp Leu 
    1085                 1090                 1095             


Phe Asn  Ser Ser Ser Ile Thr  Ser Thr Gln Lys Lys  Lys Glu Phe 
    1100                 1105                 1110             


Leu Gln  Arg Phe Glu Ser Ile  Val Tyr Ser Ala Arg  Asp Gly Gly 
    1115                 1120                 1125             


Ile Phe  Ala Phe Thr Phe Asp  Tyr Arg Asn Phe Ser  Lys Ile Ala 
    1130                 1135                 1140             


Thr Asp  His Arg Asn Met Trp  Thr Val Tyr Thr His  Gly Glu Arg 
    1145                 1150                 1155             


Ile Arg  Tyr Val Arg Asp Glu  Lys Cys Tyr Lys Thr  Thr Asp Pro 
    1160                 1165                 1170             


Thr Lys  Arg Ile Lys Glu Ala  Leu Ser Gly Ile Glu  Tyr Asp Asp 
    1175                 1180                 1185             


Gly Ser  Asp Ile Arg Asp Lys  Ile Thr Gln Ser Gly  Asp Asn Asn 
    1190                 1195                 1200             


Leu Ile  Asn Thr Val Tyr His  Ser Phe Met Asp Thr  Ile Lys Met 
    1205                 1210                 1215             


Arg Asn  Lys Asp Gly Arg Ile  Asp Tyr Ile Ile Ser  Pro Val Lys 
    1220                 1225                 1230             


Asn Arg  Asn Gly Glu Phe Phe  Arg Ser Asp Tyr Lys  His Arg Asp 
    1235                 1240                 1245             


Phe Pro  Val Asp Ala Asp Ala  Asn Gly Ala Tyr His  Ile Ala Leu 
    1250                 1255                 1260             


Lys Gly  Glu Leu Leu Met Arg  Met Ile Gly Lys Thr  Tyr Asp Ser 
    1265                 1270                 1275             


Asn Ser  Asp Lys Met Pro Lys  Leu Glu His Lys Asp  Trp Phe Glu 
    1280                 1285                 1290             


Phe Met  Gln Thr Arg Gly Asp  Gln 
    1295                 1300     


<210> 735
<211> 1188
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12b sequence"

<400> 735
Met Cys Val Ser Arg Leu Pro Trp Phe Asn Ile Thr Leu Thr Gly Lys 
1               5                   10                  15      


Leu Asn Arg Gln Arg Leu Asn Gln Met Cys Val Ser Arg Leu Pro Trp 
            20                  25                  30          


Phe Cys Thr Pro Lys Gly Gln Leu Ala Ala Thr Pro Lys Thr Val Val 
        35                  40                  45              


Ala Gln Gln Glu Asn Ala Met Leu Ala Ile Ile Arg Asp Val His Glu 
    50                  55                  60                  


Ala Ala Pro Ala Asp Leu Lys Thr Val Ala Gln Arg Leu Glu Pro Gly 
65                  70                  75                  80  


Tyr Phe Val Thr Gln Phe Pro Lys Gln Gln Met Thr Gly Asp Glu Ala 
                85                  90                  95      


Arg Ala Glu Ala Glu Arg Leu Phe Ala Ala Cys Gln Lys Lys Phe Lys 
            100                 105                 110         


Glu Leu Ala Glu Tyr Glu Asp Gly Tyr Arg Gln Cys Leu Asp Ala Leu 
        115                 120                 125             


Gly Pro Asn Leu Ser Leu Pro Arg Leu Gly Arg Lys Pro Lys Gly Ala 
    130                 135                 140                 


Tyr Pro Tyr Ala Val Val Phe Lys Leu Met Pro Thr Asn Ala Thr Trp 
145                 150                 155                 160 


Glu Cys Phe Lys Arg Val Thr Ala Ser Leu Tyr Lys Arg Ala Gln Lys 
                165                 170                 175     


Gly Val Val Ser Pro Val Ser Ala Asp Ser Ile Ala Asp Val Arg Thr 
            180                 185                 190         


Asn Asp Glu Pro Leu Phe Glu Tyr Phe Thr Asn Leu Ala Leu Val Arg 
        195                 200                 205             


Pro Pro Gly Asn Lys Asp Arg Ala Val Trp Phe Glu Phe Asp Leu Ala 
    210                 215                 220                 


Ala Phe Ile Glu Ala Ile Lys Ser Pro His Gln Phe Phe Gln Asp Thr 
225                 230                 235                 240 


Ile Lys Arg Glu Gln Ala Val Ala Gln Ile Lys Ala Lys Leu Asp Ala 
                245                 250                 255     


Met Asp Gly Gln Gly Arg Ala Ala Ser Gly Glu Glu Asp Ala Leu Pro 
            260                 265                 270         


Gly Phe Glu Gly Asp Asp Arg Ile Thr Leu Leu Arg Glu Leu Val Thr 
        275                 280                 285             


Asp Thr Leu Gly Tyr Leu Ala Glu Ala Asp Ala Ser Thr Ser Pro Gly 
    290                 295                 300                 


Gly Lys Ile Glu Tyr Ser Ile Gln Glu Arg Thr Val Arg Gly Phe Ala 
305                 310                 315                 320 


Glu Val Lys Arg Arg Trp Arg Asp Leu Val Glu Lys Gly Lys Ala Thr 
                325                 330                 335     


Glu Asp Ala Leu Leu Lys Val Leu Ala Glu Glu Gln Thr Glu His Arg 
            340                 345                 350         


Asp Asp Phe Gly Ser Ala Thr Leu Tyr Arg Glu Leu Ala Lys Pro Lys 
        355                 360                 365             


Phe Gln Pro Ile Trp Arg Asp Pro Gly Thr Gln Pro Trp His Ala Asp 
    370                 375                 380                 


Asp Pro Leu Arg Ala Trp Leu Glu Tyr Arg Glu Leu Gly Arg Glu Leu 
385                 390                 395                 400 


Glu Asp Lys Gln Arg Pro Ile Arg Phe Thr Pro Val His Pro Val His 
                405                 410                 415     


Ser Pro Arg Phe Phe Ile Phe Pro Lys Lys Lys Gly Gly Gly Arg Phe 
            420                 425                 430         


Gly Thr Val His Glu Pro Gly Gln Leu Arg Val Met Ala Gly Ile Val 
        435                 440                 445             


Ala Gln Thr Gln His Gly Trp Glu Pro Val Pro Val Arg Ile Thr Tyr 
    450                 455                 460                 


Ala Ala Pro Arg Leu Arg Arg Asp Gln Leu Arg Asp Asp Val Glu Thr 
465                 470                 475                 480 


Asp Leu Glu Ser Arg Pro Trp Leu Gln Pro Met Met Gln Ala Leu Gly 
                485                 490                 495     


Leu Pro Glu Pro Asp Thr Ala Asp Phe Ser Asn Cys Arg Val Thr Leu 
            500                 505                 510         


Gln Pro Ser Ala Pro Asp Asp Ile Gln Leu Thr Phe Pro Val Asp Val 
        515                 520                 525             


Ser Ala Asp Lys Leu Thr Thr Ala Ile Gly Lys Ala Ala Arg Trp Ala 
    530                 535                 540                 


Lys Gln Phe Asn Leu Phe Pro Asp Gly Asp Asn Phe Tyr Asn Ala Ser 
545                 550                 555                 560 


Leu Arg Trp Pro His Glu Lys Lys Pro Ser Lys Pro Pro Val Pro Trp 
                565                 570                 575     


His Glu Ala Leu Asp Asn Phe Ser Val Leu Ala Ala Asp Leu Gly Gln 
            580                 585                 590         


Arg Cys Ala Gly Ala Phe Ala Arg Leu Glu Val Arg Ala Asn Asp Asp 
        595                 600                 605             


Phe Ala Gly Lys Pro Ser Arg Phe Ile Gly Glu Thr Pro Gly Lys Lys 
    610                 615                 620                 


Trp Arg Ala Ala Leu Val Ala Ala Gly Met Leu Arg Leu Pro Gly Glu 
625                 630                 635                 640 


Glu Gln Thr Val Trp Arg Pro Gly Ala Thr Gly Pro Asn Phe His Thr 
                645                 650                 655     


Glu Leu Ser Gly Ser Arg Gly Arg Met Ala Arg Pro His Glu Ala Asp 
            660                 665                 670         


Asp Thr Ala Asp Leu Leu Arg Ala Phe Asp Cys Pro Glu Glu Ser Leu 
        675                 680                 685             


Met Pro Ala Asp Trp Arg Thr Ser Leu Ser Phe Pro Glu Gln Asn Asp 
    690                 695                 700                 


Lys Leu Leu Val Ala Ala Arg Arg Tyr Gln Ser Arg Leu Ala Arg Leu 
705                 710                 715                 720 


His Arg Trp Cys Trp Phe Leu Thr Asp Glu Lys Lys Arg Gln Thr Ala 
                725                 730                 735     


Leu Asp Glu Ile Arg Glu Ala Glu Asp Met Pro Ala Ala Asp Asp Pro 
            740                 745                 750         


Gln Leu Thr Asp Lys Leu Arg Ala Leu Leu Leu Gln Lys Gln Ala Ala 
        755                 760                 765             


Leu Pro Gly Leu Leu Val Arg Leu Ala Asn Arg Ile Leu Pro Leu Arg 
    770                 775                 780                 


Gly Arg Ser Trp Gln Trp Glu Thr His Pro Asp Lys Ala Asp Cys His 
785                 790                 795                 800 


Leu Leu Thr Gln Thr Gly Pro Ala Leu Pro Asp Val Trp Ile Arg Gly 
                805                 810                 815     


Gln Arg Gly Leu Ser Met Gln Arg Ile Glu Gln Ile Glu Glu Leu Arg 
            820                 825                 830         


Arg Arg Phe Gln Ser Leu Asn Gln Met Gln Arg Arg Glu Ile Gly Gly 
        835                 840                 845             


Lys Pro Pro Ile Arg Arg Asp Asp Ser Ile Pro Asp Cys Cys Pro Asp 
    850                 855                 860                 


Leu Leu Asp Lys Leu Asp Gln Ile Lys Glu Gln Arg Ala Asn Gln Ala 
865                 870                 875                 880 


Ala His Met Ile Leu Ala Glu Ala Leu Gly Leu Arg Leu Ala Pro Pro 
                885                 890                 895     


Pro Ala Asp Lys Arg Gln Leu Arg Ala Ser Arg Asp Val His Gly Gln 
            900                 905                 910         


Tyr Val Lys Ser Arg Glu Pro Val Asp Phe Ile Val Ile Glu Asp Leu 
        915                 920                 925             


Ser Arg Tyr Arg Ser Ser Gln Gly Arg Ala Pro Arg Glu Asn Ser Arg 
    930                 935                 940                 


Leu Met Lys Trp Cys His Arg Ala Val Arg Asp Lys Leu Arg Glu Leu 
945                 950                 955                 960 


Cys Glu Pro Phe Gly Ile Pro Val Val Glu Thr Pro Ala Ala Tyr Ser 
                965                 970                 975     


Ser Arg Phe Cys Ser Arg Ser Gly Val Ala Gly Phe Arg Ala Val Glu 
            980                 985                 990         


Val Gly Pro Gly Phe Asp Arg Glu  Phe Pro Trp Met Met  Leu Lys Asp 
        995                 1000                 1005             


Arg Glu  Asp Glu Gly Glu Pro  Val Arg Gln Leu Ile  Leu Gln Val 
    1010                 1015                 1020             


Ala Thr  Leu Asn Gln Gly Arg  Asp Gly Lys Pro Pro  Arg Thr Leu 
    1025                 1030                 1035             


Leu Ala  Pro Leu Ala Gly Gly  Pro Ile Phe Val Pro  Ile Val Asp 
    1040                 1045                 1050             


Lys Leu  Asn Gly Ala Asp Ile  Gln Pro Ala Leu Ala  Gln Ala Asp 
    1055                 1060                 1065             


Ile Asn  Ala Ala Ile Asn Leu  Gly Leu Arg Ala Ile  Ala Asp Pro 
    1070                 1075                 1080             


Arg Leu  Trp Ser Ile His Pro  Arg Cys Arg Thr Gln  Arg Gln Gly 
    1085                 1090                 1095             


Asp Gln  Met Leu Thr Arg Glu  Lys Arg Lys Phe Gly  Glu Thr Gly 
    1100                 1105                 1110             


Gln Pro  Leu Ala Val His Arg  Ala Asp Gly Val Lys  Pro Asp Asp 
    1115                 1120                 1125             


Thr Arg  Asn Pro Asn Phe Phe  Ala Asp Ile Ser Gly  Ser Leu Pro 
    1130                 1135                 1140             


Ala Trp  Glu Ser Ala Thr Leu  Asp Gly Gln His Leu  Leu Ser Gly 
    1145                 1150                 1155             


Arg Cys  Leu Arg Ser Glu Ile  Lys Lys Arg Gln Trp  Gln Arg Cys 
    1160                 1165                 1170             


Ala Glu  Ile Asn Asp Arg Arg  Met Asn Arg Trp Met  Lys Gly Glu 
    1175                 1180                 1185             


<210> 736
<211> 1518
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12b sequence"

<400> 736
Met Thr Glu Leu Gln Thr Gln Arg Ala Tyr Thr Leu Arg Leu Lys Gly 
1               5                   10                  15      


Ile Asp Glu Lys Asp Gln Ser Trp Arg Asp Ala Leu Trp Lys Thr His 
            20                  25                  30          


Glu Ala Val Asn Lys Gly Ala Lys Val Phe Gly Asp Trp Leu Leu Thr 
        35                  40                  45              


Leu Arg Gly Gly Leu Asp His Thr Leu Ala Asp Ala Glu Ile Pro Gly 
    50                  55                  60                  


Glu Lys Gly Lys Pro Asp Arg Ala Pro Thr Gln Glu Glu Arg Lys His 
65                  70                  75                  80  


Arg Arg Ile Leu Leu Ala Leu Ser Trp Leu Ser Val Glu Ser Glu Arg 
                85                  90                  95      


Gly Ala Pro Glu Glu Phe Ile Val Ala Thr Gly Lys Glu Pro Ala Ala 
            100                 105                 110         


Thr Arg Asn Asp Lys Val Ile Ala Ala Leu Lys Asp Ile Leu Arg Gly 
        115                 120                 125             


Arg Asn Leu Thr Glu Glu Lys Ile Ser Glu Trp Thr Glu Val Cys Thr 
    130                 135                 140                 


Pro Ser Leu Ser Ala Ala Ile Arg Glu Asp Ala Val Trp Val Asn Arg 
145                 150                 155                 160 


Ser Arg Ala Phe Asp Glu Ala Val Lys Arg Ile Gly Ser Ser Leu Thr 
                165                 170                 175     


Arg Glu Glu Val Trp Asp Met Leu Glu Cys Phe Phe Gly Ser Arg Asn 
            180                 185                 190         


Ala Tyr Leu Ala Pro Val Lys Ile Ser Glu Asp Glu Ser Ser Asp Gly 
        195                 200                 205             


Glu Gln Glu Glu Lys Ala Lys Asp Leu Val Gln Lys Ala Gly Gln Trp 
    210                 215                 220                 


Leu Ser Ser Arg Phe Gly Thr Gly Glu Gly Ala Asp Phe Ala Lys Met 
225                 230                 235                 240 


Ala Ala Val Tyr Ala Lys Ile Ala Ala Trp Ala Gly Asn Ala Gln Ala 
                245                 250                 255     


Gly Thr Thr Gly Asn Glu Val Ile Asn Asn Leu Ala Thr Ala Leu Arg 
            260                 265                 270         


Glu Phe Thr Pro Lys Ser Asn Asp Leu Lys Gly Val Leu Asp Leu Ile 
        275                 280                 285             


Ser Gly Pro Gly Tyr Lys Ser Ala Thr Arg Asn Leu Leu Lys Gln Ile 
    290                 295                 300                 


Ala Asn Thr Lys Thr Val Thr Arg Glu Asp Ile Ser Lys Leu Gln Glu 
305                 310                 315                 320 


Thr Ala Gly Glu Asp Ser Glu Glu Cys Ala Thr Lys Thr Gly Ser Lys 
                325                 330                 335     


Gly Lys Arg Ala Tyr Ala Asp Ala Ile Leu Lys Asp Val Glu Ser Val 
            340                 345                 350         


Cys Gly Phe Thr Tyr Arg Ile Asp Lys Asp Gly Gln Pro Val Ser Val 
        355                 360                 365             


Ala Asp Tyr Ser Lys Tyr Asp Glu Asp Tyr Lys Trp Gly Ser Ser Arg 
    370                 375                 380                 


His Lys Glu Phe Ala Val Met Leu Asp His Ala Ala Arg Arg Val Ser 
385                 390                 395                 400 


Leu Ala His Thr Trp Ile Lys Arg Ala Glu Ala Glu Arg Arg Lys Phe 
                405                 410                 415     


Glu Glu Asp Ser Lys Lys Ile Met Gln Val Pro Gln Ala Ala Lys Asp 
            420                 425                 430         


Trp Leu Asp Ala Tyr Cys Ala Gln Arg Ser Glu Ala Ser Gly Ala Leu 
        435                 440                 445             


Glu Pro Tyr Arg Ile Arg Lys Arg Ala Ile Gln Gly Trp Lys Glu Ile 
    450                 455                 460                 


Ile Ala Ser Trp Asn Lys Pro Asp Cys Lys Thr Ala Glu Asp Arg Ile 
465                 470                 475                 480 


Ala Ala Ala Arg Gln Leu Gln Asp Asp Pro Glu Ile Glu Lys Phe Gly 
                485                 490                 495     


Asp Ile Gln Leu Phe Glu Ala Leu Ala Glu Asp Asp Ala Gln Cys Val 
            500                 505                 510         


Trp Lys Lys Glu Asp Gly Thr Leu Asp Pro Glu Ile Leu Ile Asn Tyr 
        515                 520                 525             


Thr Leu Ala Ser Glu Ala Met Phe Lys Lys Gln His Phe Lys Val Pro 
    530                 535                 540                 


Ser Tyr Arg His Pro Asp Ala Phe Leu Tyr Pro Val Phe Cys Asp Phe 
545                 550                 555                 560 


Gly Asn Ser Arg Trp Glu Leu Asp Phe Ser Ile Arg Glu Ala Ala Thr 
                565                 570                 575     


Lys Leu Lys Glu Ile Glu Ala Lys Ile Glu Lys Gln Arg Gln Glu Val 
            580                 585                 590         


His Lys Val Gln Gln Ala Leu Glu Lys Cys Glu Asn Asp Glu Lys Arg 
        595                 600                 605             


Pro Lys Met Glu Glu Arg Leu Lys Glu Ala Gln Lys Lys Leu Gln Glu 
    610                 615                 620                 


Ser Gln Asn Tyr Gly Glu Tyr Leu His Ser Asn Asn Lys Ile Thr Met 
625                 630                 635                 640 


Val Leu Phe Asp Gly Thr Phe Val Lys Lys His Ile Phe Ala Trp Gln 
                645                 650                 655     


Ser Lys Arg Leu Thr Lys Asp Leu Ala Leu Tyr Gln Glu Pro Ser Ala 
            660                 665                 670         


Asp Pro Lys Asn Val Val Ser Arg Ala Asp Arg Leu Gly Arg Ala Val 
        675                 680                 685             


Ala Ser Val Gly Ile Asn Asp Ala Val Lys Val Ala Gly Leu Phe Glu 
    690                 695                 700                 


Gln Glu Asn Trp Asn Gly Arg Leu Gln Ala Pro Arg Gln Gln Leu Glu 
705                 710                 715                 720 


Ala Ile Ala Gln Tyr Val Glu Lys His Gly Trp Asp Asn Lys Ala Glu 
                725                 730                 735     


Lys Met Arg Ala Ser Ile Lys Trp Phe Ile Thr Phe Ser Ala Lys Leu 
            740                 745                 750         


Gln Ser Lys Gly Pro Trp Asn Glu Phe Ala Arg Lys His Gly Leu Lys 
        755                 760                 765             


Glu Asp Pro His Tyr Trp Pro His Ala Glu Lys Asn Glu Asn Arg Thr 
    770                 775                 780                 


Ala His Ser Arg Leu Ile Leu Ser Arg Leu Pro Gly Leu Arg Val Leu 
785                 790                 795                 800 


Ser Val Asp Leu Gly His Arg Tyr Ala Ala Ala Cys Ala Val Trp Glu 
                805                 810                 815     


Ala Leu Gly Ser Glu Ala Phe Lys Lys Asp Ile Glu Gly Lys Arg Ile 
            820                 825                 830         


Ile Arg Gly Asp Thr Asp Glu Asn Ala Leu Tyr Cys His Thr Glu His 
        835                 840                 845             


Glu Ala Asn Gly Lys Lys His Ile Thr Ile Tyr Arg Arg Ile Gly Ala 
    850                 855                 860                 


Asp Thr Leu Pro Asp Gly Ala His His Pro Ala Pro Trp Ala Arg Leu 
865                 870                 875                 880 


Asp Arg Gln Phe Leu Ile Lys Leu Gln Gly Glu Asp Glu Gln Ala Arg 
                885                 890                 895     


Glu Ala Ser Asn Glu Glu Ile Trp Lys Val His Gln Leu Glu Asn Thr 
            900                 905                 910         


Leu Gly Arg Arg Thr Pro Leu Ile Asp Arg Leu Ile Ala Gly Gly Trp 
        915                 920                 925             


Gly Tyr Thr Glu Lys Gln Lys Ala Arg Leu Glu Val Leu Thr Asn Leu 
    930                 935                 940                 


Gly Trp Cys Pro Thr Asn Lys Thr Asp Asn Gln Glu Glu Gly Asp Glu 
945                 950                 955                 960 


Glu Glu Thr Ala Ile Leu Ser Lys Pro Ser Leu Leu Val Asp Asp Leu 
                965                 970                 975     


Met Phe Ser Ala Val Arg Thr Leu Arg Leu Ala Leu Lys Arg His Gly 
            980                 985                 990         


Asp Arg Ala Arg Ile Ala His Tyr  Leu Ile Thr Asp Glu  Lys Thr Lys 
        995                 1000                 1005             


Pro Gly  Gly Val Lys Glu Lys  Leu Asp Lys Asn Gly  Arg Val Glu 
    1010                 1015                 1020             


Leu Leu  Leu Asp Ala Leu Gly  Leu Trp His Asp Leu  Phe Ser Ser 
    1025                 1030                 1035             


Pro Gly  Trp His Asp Glu Lys  Ala Lys Gln Leu Trp  Asn Ala Tyr 
    1040                 1045                 1050             


Ile Ala  Gly Leu Leu Pro Glu  Gly Glu Leu Gln Gln  Ala Lys Ser 
    1055                 1060                 1065             


Val Thr  Thr Ser Ala Ala Leu  Gly Gly Gln Gln Lys  Lys Glu Lys 
    1070                 1075                 1080             


Lys Glu  Lys Leu Arg Ala Val  Ala Glu Ala Leu Tyr  Leu Asn Ser 
    1085                 1090                 1095             


Asp Leu  Cys His Ser Leu Asn  Glu Val Trp Arg Lys  Arg Trp Glu 
    1100                 1105                 1110             


Glu Asp  Asp Lys Gln Trp Arg  Ile Tyr Ile Arg Trp  Phe Lys Asp 
    1115                 1120                 1125             


Trp Ile  Met Pro Arg Gly Ala  Asn Ala Lys Ser Pro  Ala Ile Arg 
    1130                 1135                 1140             


His Val  Gly Gly Leu Ser Leu  Thr Arg Leu Ala Thr  Leu Thr Glu 
    1145                 1150                 1155             


Phe Arg  Arg Lys Val Gln Val  Gly Phe Phe Thr Arg  Leu His Pro 
    1160                 1165                 1170             


Asp Gly  Thr Lys Thr Glu Thr  Arg Glu Asp Phe Gly  Gln Lys Thr 
    1175                 1180                 1185             


Leu Asp  Thr Leu Glu His Leu  Arg Glu Gln Arg Val  Lys Gln Leu 
    1190                 1195                 1200             


Ala Ser  Arg Ile Val Glu Ala  Ala Leu Gly Ile Gly  Ser Glu Asp 
    1205                 1210                 1215             


Lys Arg  His Trp Asp Gly Lys  Lys Arg Pro Arg Gln  Arg Ile Ala 
    1220                 1225                 1230             


Asp Pro  Arg Phe Val Pro Cys  His Ala Val Val Ile  Glu Asn Leu 
    1235                 1240                 1245             


Thr His  Tyr Arg Pro Glu Glu  Thr Arg Thr Arg Arg  Glu Asn Arg 
    1250                 1255                 1260             


Gln Ile  Met Glu Trp Ala Ser  Ser Lys Val Lys Lys  Tyr Leu Ser 
    1265                 1270                 1275             


Glu Ile  Cys Gln Leu His Gly  Leu His Leu Arg Glu  Val Ser Ala 
    1280                 1285                 1290             


Ala Tyr  Thr Ser His Gln Asp  Ser Arg Thr Gly Ala  Pro Gly Ile 
    1295                 1300                 1305             


Arg Cys  Gln Asp Val Ser Leu  Ile Glu Phe Met Lys  Ser Pro Phe 
    1310                 1315                 1320             


Trp Arg  Lys Gln Val Ala Gln  Ala Glu Lys Lys Gln  Lys Glu Gly 
    1325                 1330                 1335             


Lys Gly  Asp Ala Val Glu Arg  Tyr Leu Cys Glu Leu  Asn Gln Lys 
    1340                 1345                 1350             


Trp Lys  Gly Ala Ser Glu Glu  Glu Trp Arg Lys Ala  Gly Phe Val 
    1355                 1360                 1365             


Arg Ile  Pro Leu Arg Gly Gly  Glu Ile Phe Val Ser  Ala Ala Gly 
    1370                 1375                 1380             


His Asp  Ser Pro Ala Ala Lys  Gly Ile His Ala Asp  Leu Asn Ala 
    1385                 1390                 1395             


Ala Ala  Asn Ile Gly Leu Arg  Ala Leu Leu Asp Pro  Asp Trp Ser 
    1400                 1405                 1410             


Gly Lys  Trp Trp Tyr Val Pro  Cys Asn Ser Ser Thr  Met Cys Pro 
    1415                 1420                 1425             


Ala Arg  Asp Lys Val Thr Gly  Ser Ala Ala Val Asn  Pro Gly Gln 
    1430                 1435                 1440             


Pro Leu  Gln Val Ser Ala Gln  Leu Glu Ser Asp Asp  Ala Ala Lys 
    1445                 1450                 1455             


Asp Thr  Lys Lys Arg Lys Lys  Lys Gly Asp Gly Lys  Ser Lys Glu 
    1460                 1465                 1470             


Ile Ile  Asn Leu Trp Arg Asp  Ile Ser Ser Tyr Pro  Leu Glu Asp 
    1475                 1480                 1485             


Thr Arg  Gly Gly Thr Trp Ser  Asn Lys Thr Val Tyr  Trp Asn Arg 
    1490                 1495                 1500             


Val Gln  Ser Asn Val Val His  Ile Leu Gln Asn Gln  Met Lys Gly 
    1505                 1510                 1515             


<210> 737
<211> 1374
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12b sequence"

<400> 737
Met Pro Glu Thr Thr Gln Arg Ala Tyr Thr Leu Arg Leu Gln Gly His 
1               5                   10                  15      


Asp Pro Lys Asp Ala Ser Trp Arg Glu Ala Leu Trp Lys Thr His Glu 
            20                  25                  30          


Ala Val Asn Arg Gly Ala Lys Ala Phe Gly Asp Trp Leu Leu Thr Leu 
        35                  40                  45              


Arg Gly Gly Leu Asp His Ser Leu Ala Asp Glu Gly Ala Pro Gly Gln 
    50                  55                  60                  


Thr Pro Thr Glu Glu Gln Arg Lys Gln Arg Arg Ile Leu Leu Ala Leu 
65                  70                  75                  80  


Ser Trp Leu Ser Val Glu Ser Glu Asn Gly Ala Pro Gln Glu Tyr Ile 
                85                  90                  95      


Val Pro His Asp Arg Asp Asn Glu Ser Gly Ala Arg Gln Asn Trp Lys 
            100                 105                 110         


Thr Arg Glu Ala Leu Arg Glu Ile Leu Lys Asn Arg Gly Cys Arg Asp 
        115                 120                 125             


Asp Glu Ile Glu Ser Trp Cys His Asp Cys Glu Pro Ser Leu Thr Ser 
    130                 135                 140                 


Ala Ile Arg Lys Asp Ala Val Trp Val Asn Arg Ser Lys Ala Phe Asp 
145                 150                 155                 160 


Asn Ala Val Gln Ser Ile Pro Asn Phe Ser Arg Glu Glu Ile Trp Asp 
                165                 170                 175     


Leu Leu Gly Cys Phe Phe Val Ser Ser Gln Ala Tyr Leu Ala Pro Leu 
            180                 185                 190         


Glu Ser Pro Lys Asp Asp Lys Pro Asp Ala Ser Lys Lys Asp Ser Ser 
        195                 200                 205             


Lys Asp Leu Ile Gln Ser Ala Gly Gln Trp Leu Ser Arg Arg Phe Gly 
    210                 215                 220                 


Arg Gly Lys Gly Leu Asn Phe Ala Arg Leu Ala Glu Thr Tyr Glu Ala 
225                 230                 235                 240 


Ile Ala Arg Trp Ala Ser Val Ala Asn Pro Gly Asp Thr Asn Asp Leu 
                245                 250                 255     


Ile Ala Asp Leu Ala Lys Thr Leu Asn Ala Glu Thr Pro Glu Leu Asp 
            260                 265                 270         


Gly Ile Leu Lys Val Val Ser Gly Pro Gly His Lys Ser Lys Thr Arg 
        275                 280                 285             


Asn Leu Leu Arg Ser Leu Ser Ala Val Asn His Ile Thr Lys Asp Thr 
    290                 295                 300                 


Leu Gln Arg Leu Lys Asp Thr Ala Asn Glu Asp Ala Lys Lys Ala Lys 
305                 310                 315                 320 


Leu Lys Lys Gly Glu Lys Gly His Arg Ala Tyr Ala Tyr Lys Val Leu 
                325                 330                 335     


Glu Ala Val Glu Asp Ala Cys Gly Phe Thr Tyr Leu Gln Glu Gly Asp 
            340                 345                 350         


Arg Ala Lys His Cys Glu Phe Ala Val Met Leu Asp His Ala Ala Arg 
        355                 360                 365             


Arg Val Ser Ser Leu His Thr Trp Ile Lys Arg Ala Glu Ala Glu Arg 
    370                 375                 380                 


Arg Arg Phe Glu Ile Asp Thr Lys Lys Lys Asp Gln Leu Pro Pro Ser 
385                 390                 395                 400 


Val Lys Glu Trp Leu Asp Thr Tyr Cys Gln Lys Arg Ser Lys Glu Thr 
                405                 410                 415     


Gly Ala Val Glu Pro Tyr Arg Ile Arg Arg Gly Ala Ile Glu Gly Trp 
            420                 425                 430         


Lys Glu Ile Val Glu Ala Trp Ser Lys Ala Gly Thr Thr Thr Ala Glu 
        435                 440                 445             


Asp Arg Lys His Glu Ala Arg Arg Leu Pro Asp Asn Pro His Ile Asp 
    450                 455                 460                 


Lys Ser Gly Asp Ile Lys Leu Phe Glu Asp Leu Ala Leu Glu Asp Ala 
465                 470                 475                 480 


Leu Pro Val Trp His Ala Asn Gly Asp Pro Asn Asn Pro Pro Asp Pro 
                485                 490                 495     


Gln Leu Leu Ile Asp Tyr Val Glu Gly Ser Glu Ala Glu Phe Lys Lys 
            500                 505                 510         


Arg Ala Phe Lys Val Pro Thr Tyr Cys His Pro Asp Pro Leu Val His 
        515                 520                 525             


Pro Val Phe Cys Asp Tyr Gly Cys Ser Arg Trp Asn Val Ser Phe Ala 
    530                 535                 540                 


Ile Gln Pro Val Lys Lys Gln Lys Leu Ser Ser Glu Glu Lys Leu Pro 
545                 550                 555                 560 


Ala Lys Gly Leu Leu Leu Asp Leu Leu His Gly Thr Ala Ile Arg Pro 
                565                 570                 575     


Val Ala Leu Arg Trp Gln Ser Lys Arg Phe Ala Arg Asp Leu Ala Leu 
            580                 585                 590         


Asn Thr Thr Asp Ser Ser Asp Lys Pro Asn Glu Val Thr Arg Ala Asp 
        595                 600                 605             


Arg Phe Gly Cys Ala Leu Ala Lys Cys Pro Ser Ser Gln Lys Ile Arg 
    610                 615                 620                 


Ile Arg Gly Leu Phe Glu Glu Lys Tyr Trp Asn Gly Arg Leu Gln Ala 
625                 630                 635                 640 


Pro Arg Pro Glu Leu Thr Ala Leu Ala Lys Arg Val Ala Lys Tyr Gly 
                645                 650                 655     


Trp Asp Lys Lys Ala Arg Lys Leu Arg Asn Ser Leu Asn Trp Phe Ile 
            660                 665                 670         


Thr Phe Ser Ala Asn Leu Arg Pro Ser Gly Pro Trp Glu Glu Tyr Thr 
        675                 680                 685             


Lys Tyr Ala Glu Lys Ala Phe Ser Ser Asn Ala Ser Ala Lys Pro Ser 
    690                 695                 700                 


Val Ser Arg Gly Gly Phe Trp Val Val His Ala Ser Pro Asn Lys Arg 
705                 710                 715                 720 


Gly Lys Met Ala Gln Leu Arg Leu Cys Arg Leu Pro Glu Leu Arg Val 
                725                 730                 735     


Leu Ser Val Asp Leu Gly His Arg Tyr Ala Ala Ala Cys Ala Val Trp 
            740                 745                 750         


Glu Thr Leu Ser Lys Ser Ala Phe Glu Gln Glu Ile His Glu Arg Lys 
        755                 760                 765             


Ile Leu Arg Gly Gly Thr Gly Pro Asn Asp Leu Phe Cys His Thr Gln 
    770                 775                 780                 


His Asp Thr Asn Gly Gln Ser Lys Val Thr Ile Tyr Arg Arg Ile Gly 
785                 790                 795                 800 


Ala Asp Thr Leu Pro Asn Gly Thr Pro His Pro Ala Pro Trp Ala Arg 
                805                 810                 815     


Leu Asp Arg Gln Phe Leu Ile Lys Leu Pro Gly Glu Glu Arg Glu Ala 
            820                 825                 830         


Arg Lys Ala Ser Pro Thr Glu Leu Ala Asn Val Glu Lys Leu Glu Lys 
        835                 840                 845             


Glu Leu Gly Leu Lys Thr Ser Glu Asn Arg Val Lys Arg Ile Asp Asp 
    850                 855                 860                 


Leu Met Ser Asp Thr Leu Arg Thr Val Arg Gln Ala Leu Arg Arg His 
865                 870                 875                 880 


Ser Leu Arg Ala Arg Ile Ala Phe Asn Leu Ala Thr Leu Arg Asp Gln 
                885                 890                 895     


Ser Asp Gly Asp Glu Glu Ser Gln Ser Lys Gln Lys Arg Asp Thr Arg 
            900                 905                 910         


Trp Asn Asn Thr Val Lys Ile Trp His Ser Leu Leu Glu Ser Asn Glu 
        915                 920                 925             


Trp Thr Asp Asp Trp Ala Lys Ala Leu Trp Asp Glu Leu Gly Pro Leu 
    930                 935                 940                 


Ser Asp Pro Gln Lys Ala Asp Asp Ala Glu Trp Leu Lys Leu Ala Ala 
945                 950                 955                 960 


Glu Lys Phe Tyr Thr Arg Trp Gln Glu Asp Glu Gln Thr Trp Arg Glu 
                965                 970                 975     


Arg Leu Arg Trp Leu Arg Arg Trp Ile Leu Pro Arg Gly Ser Gln Ala 
            980                 985                 990         


Ala Ser Gln Lys Gly Ser Ile Arg  His Val Gly Gly Leu  Ser Leu Thr 
        995                 1000                 1005             


Arg Leu  Ala Thr Ile Lys Thr  Leu Tyr Gln Val Leu  Lys Ala Tyr 
    1010                 1015                 1020             


His Met  Arg Leu Lys Pro Asp  Asn Ser Arg Lys Asn  Ile Pro Ala 
    1025                 1030                 1035             


Glu Gly  Asp Glu Ala Leu Gln  Asn Phe Gly Gln Lys  Ile Leu Asp 
    1040                 1045                 1050             


Asp Leu  Glu His Met Arg Glu  Gln Arg Val Lys Gln  Leu Ala Ser 
    1055                 1060                 1065             


Arg Ile  Val Glu Ala Ala Leu  Gly Leu Gly Arg Met  Lys Gln Val 
    1070                 1075                 1080             


Thr Ile  Gly Lys Asp Pro Lys  Arg Pro Arg Glu Pro  Val Asp Gln 
    1085                 1090                 1095             


Ser Cys  His Ala Val Val Ile  Glu Asn Leu Thr His  Tyr Arg Pro 
    1100                 1105                 1110             


Glu Lys  Arg Gln Thr Arg Arg  Glu Asn Arg Gln Leu  Met Asp Trp 
    1115                 1120                 1125             


Ser Ala  Ala Lys Val Lys Lys  Tyr Leu Lys Glu Cys  Cys Gln Leu 
    1130                 1135                 1140             


His Gly  Leu His Leu Val Glu  Val Ser Ala Ser Tyr  Thr Ser Arg 
    1145                 1150                 1155             


Gln Asp  Ser Arg Thr Gly Ala  Pro Gly Ile Arg Cys  Gln Glu Val 
    1160                 1165                 1170             


Pro Leu  Thr Asp Phe Leu Lys  Lys Asn Phe Trp Arg  Glu Gln Val 
    1175                 1180                 1185             


Lys Gln  Ala Lys Gln Arg Leu  Ser Glu Gly Lys Ala  Asn Ala Arg 
    1190                 1195                 1200             


Asp Arg  Tyr Leu Cys Gln Leu  Asn Glu Arg Trp Gly  Asn Ala Pro 
    1205                 1210                 1215             


Ala Pro  Val Thr Gln Thr Ala  Ile Arg Leu Arg Ile  Pro Leu Asn 
    1220                 1225                 1230             


Gly Gly  Glu Leu Phe Val Ser  Ala Asp Gln Asn Ser  Pro Ala Ser 
    1235                 1240                 1245             


Lys Gly  Ile Gln Ala Asp Leu  Asn Ala Ala Ala Asn  Ile Gly Leu 
    1250                 1255                 1260             


Arg Ala  Ile Thr Asp Pro Asp  Trp Pro Gly Ala Trp  Trp Tyr Val 
    1265                 1270                 1275             


Pro Cys  Glu Ala Asn Thr Phe  Lys Pro Val Lys Asp  Lys Val Ala 
    1280                 1285                 1290             


Gly Ser  Ala Ala Ile Asp Ser  Asn Val Ser Leu Lys  Lys Asp Ser 
    1295                 1300                 1305             


Pro Asn  Ser Glu Lys Pro Ala  Ser Asp Arg Lys Ser  Arg Thr Ser 
    1310                 1315                 1320             


Lys Ser  Met Ile Asn Leu Trp  Cys Asp Thr Ser Ser  Lys Ser Leu 
    1325                 1330                 1335             


Ser Glu  Lys Asp Gln Trp Gln  Glu Ser Ala Pro Tyr  Trp Glu Asp 
    1340                 1345                 1350             


Val Ala  Ala Arg Thr Ile Asn  Ile Leu Gln Ala Ser  Leu Ala Cys 
    1355                 1360                 1365             


Ser Thr  Thr Asn Ser Gln 
    1370                 


<210> 738
<211> 1335
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12a sequence"

<400> 738
Met Lys Ser Leu Ala Gln Phe Gln Asn Leu Tyr Ala Leu Gln Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Glu Gly His Thr Arg Glu Thr Phe Asn 
            20                  25                  30          


Arg Trp Leu Glu Glu Ile Glu Lys Glu Gln Ala Ser Glu Asn Glu Asn 
        35                  40                  45              


Ile Val Tyr Gln Asp Leu Leu Arg Ala Lys Lys Tyr Glu Lys Ile Lys 
    50                  55                  60                  


Ile Ile Leu Asp Glu Tyr His Lys Asp Phe Ile Glu Gln Ala Leu Ala 
65                  70                  75                  80  


Tyr Ala Asn Leu Thr Glu Leu Glu Lys Tyr Glu Glu Leu Tyr Arg Lys 
                85                  90                  95      


Ser Asn Arg Thr Ser Glu Glu Glu Glu Glu Phe Glu Asn Thr Lys Glu 
            100                 105                 110         


Ser Leu Arg Lys Gln Ile Ala Asn Ile Phe Ile Lys Asn Pro Asn Lys 
        115                 120                 125             


Thr Val Gln Glu Arg Trp Lys Phe Leu Phe Ser Lys Lys Leu Ile Gln 
    130                 135                 140                 


Asn Glu Leu Ile Val Trp Val Lys Gly Asn Tyr Glu Leu Leu Ser Glu 
145                 150                 155                 160 


Lys Leu Lys Asn Glu Phe Pro Asp Glu Ser Ser Ile Ile Ser Thr Ile 
                165                 170                 175     


Glu Asp Phe Lys Tyr Phe Thr Thr Tyr Phe Arg Asn Tyr His Glu Asn 
            180                 185                 190         


Arg Lys Asn Leu Tyr Ser Asn Glu Asp Lys Phe Ser Thr Ile Ala His 
        195                 200                 205             


Arg Leu Ile His Glu Asn Leu Pro Lys Phe Ile Asp Asn Ile Ala Ile 
    210                 215                 220                 


Tyr Gln Lys Ala Lys Ala Val Leu Asn Ile Asn Glu Val Glu Lys Glu 
225                 230                 235                 240 


Leu Gly Leu Pro Glu Asp Thr Leu Asp Lys Ile Phe Ser Leu Asp Phe 
                245                 250                 255     


Phe Ser Lys Ala Leu Thr Gln Lys Gly Ile Asp Gln Tyr Asn Tyr Phe 
            260                 265                 270         


Leu Gly Gly Lys Thr Glu Asn Glu Val Lys Lys Ile Lys Gly Leu Asn 
        275                 280                 285             


Glu Phe Ile Asn Leu Tyr Asn Gln Gln Gln Gln Asp Lys Asn Gln Arg 
    290                 295                 300                 


Leu Pro Phe Leu Lys Val Leu Tyr Lys Leu Pro Leu Phe Glu Arg Thr 
305                 310                 315                 320 


Ser Thr Ser Phe Arg Phe Glu Pro Ile Glu Asn Asp Arg Asp Leu Ile 
                325                 330                 335     


Glu Arg Ile Gly Lys Phe Tyr Tyr Asn Asp Leu Lys Gln Tyr Arg Asp 
            340                 345                 350         


Asp Ser Gln Gly Asp Thr Thr Asp Ile Leu Ser Gly Ile Asn Thr Leu 
        355                 360                 365             


Leu Arg His Val His Asp Tyr Arg Asp Gly Leu Tyr Val Asn Gly Gly 
    370                 375                 380                 


Ile Thr Leu Thr Gln Ile Ser Gln Lys Ile Phe Gly Ser Trp Ser Tyr 
385                 390                 395                 400 


Ile Asn Asn Ala Leu Ala Tyr Phe Tyr Asp Thr Tyr Ile Asp Ala Ser 
                405                 410                 415     


Gly Val Asp His Gln Gly Glu Arg Lys Pro Lys Lys Gln Lys Gln Ile 
            420                 425                 430         


Gln Glu Lys Thr Lys Trp Leu Lys Gln Lys Gln Phe Pro Val Ile Leu 
        435                 440                 445             


Val Glu Lys Ala Leu Ser Glu Tyr Lys Ser Ile Glu Thr Asn Glu Asp 
    450                 455                 460                 


Leu Lys Thr Arg Ile Ser Asp Thr Thr Leu Cys Asp Phe Phe Lys Arg 
465                 470                 475                 480 


Cys Gly Asn Asp Asp Asn Gly Gln Asp Leu Phe Asp Arg Ile Glu Ala 
                485                 490                 495     


Arg Leu Arg Glu Lys Asn Glu Glu Gly Tyr Ser Leu Glu Asp Leu Leu 
            500                 505                 510         


Lys Lys Glu Phe Thr Thr Glu Arg Lys Leu Met Gln Asp Lys Thr Lys 
        515                 520                 525             


Thr Leu Leu Ile Lys Asn Phe Leu Asp Val Ile Gln Gly Asp Lys Asp 
    530                 535                 540                 


Asp Ile Thr Ala Gly Leu Leu His Phe Val Lys Cys Leu Ile Pro Arg 
545                 550                 555                 560 


Thr Glu Ile Ser Glu Lys Asn Glu Leu Phe Tyr Ser Gly Met Glu Lys 
                565                 570                 575     


Tyr Leu Asn Ile Leu Ser Glu Val Thr Pro Leu Tyr Asn Lys Ala Arg 
            580                 585                 590         


Asn Tyr Leu Thr Gln Lys Pro Tyr Ser Ile Glu Lys Val Lys Leu Asn 
        595                 600                 605             


Phe Glu Asn Ser Thr Leu Leu Asp Gly Trp Asp Glu Asn Glu Glu Ser 
    610                 615                 620                 


Asp Asn Ser Cys Val Leu Leu Arg Lys Arg Gly Tyr Tyr Tyr Leu Gly 
625                 630                 635                 640 


Ile Met Asn Lys Lys His Asn Met Ile Phe Asp Arg Lys Ile Tyr Pro 
                645                 650                 655     


Lys Ala Thr Glu Gly Glu Ala Tyr Tyr Glu Lys Met Ile Tyr Lys Leu 
            660                 665                 670         


Leu Pro Gly Ala Tyr Lys Met Leu Pro Lys Val Phe Phe Ser Glu Lys 
        675                 680                 685             


Asn Ile Asp Tyr Phe Lys Pro Ser Glu Glu Ile Leu Arg Ile Arg Asn 
    690                 695                 700                 


Thr Ala Ser Tyr Ser Lys Asn Gly Gln Pro Gln Glu Gly Tyr Gln Lys 
705                 710                 715                 720 


Ala Ser Phe Ser Ile Glu Asp Cys Arg Lys Tyr Ile Asp Phe Phe Lys 
                725                 730                 735     


Lys Cys Ile Ala Asn His Trp Asp Trp Gln Lys Phe Asn Phe Asn Phe 
            740                 745                 750         


Ser Pro Thr Glu Tyr Tyr Gln Ser Ile Asp Glu Phe Tyr Arg Glu Ile 
        755                 760                 765             


Glu Arg Gln Gly Tyr Lys Ile Asp Phe Val Lys Ile Pro Glu Ser Tyr 
    770                 775                 780                 


Ile Asn Gln Leu Ile Lys Glu Asn Lys Leu Tyr Leu Phe Lys Ile Tyr 
785                 790                 795                 800 


Asn Lys Asp Phe Ser Glu Lys Lys Lys Ser Lys Gly Lys Asp Asn Leu 
                805                 810                 815     


His Thr Leu Tyr Trp Lys Met Leu Phe Asp Glu Lys Asn Leu Lys Asp 
            820                 825                 830         


Val Val Leu Lys Leu Asn Gly Glu Ala Glu Val Phe Phe Arg Gln Lys 
        835                 840                 845             


Ser Ile Leu Tyr Asn Glu Glu Ile Trp Asn Lys Gly His His Tyr Ser 
    850                 855                 860                 


Glu Leu Lys Asp Arg Phe Ser Tyr Pro Ile Ile Ser Asn Lys Arg Tyr 
865                 870                 875                 880 


Ala Glu Asp Lys Phe Phe Leu His Val Pro Ile Thr Leu Asn Phe Lys 
                885                 890                 895     


Ala Asp Gly Ile Asn Asn Val Asn Asn Met Val Asn Glu Phe Ile Lys 
            900                 905                 910         


Asp Asn Arg Asp Ile His Ile Ile Gly Ile Asp Arg Gly Glu Arg His 
        915                 920                 925             


Leu Leu Tyr Val Ser Val Ile Asn Gln Lys Gly Asp Ile Val Glu Gln 
    930                 935                 940                 


Cys Ser Leu Asn Glu Ile Val Thr Glu Tyr Asn Gly Lys Ile Phe Lys 
945                 950                 955                 960 


Lys Asn Tyr His Glu Glu Leu Asp Asn Leu Glu Lys Glu Arg Asp Arg 
                965                 970                 975     


Ala Arg Lys Asp Trp Gln Thr Ile Ala Asn Ile Lys Glu Leu Lys Glu 
            980                 985                 990         


Gly Tyr Leu Ser His Val Ile His  Lys Ile Ser Lys Leu  Ile Leu Lys 
        995                 1000                 1005             


Tyr Asn  Ala Ile Val Val Met  Glu Asp Leu Asn Ser  Gly Phe Lys 
    1010                 1015                 1020             


Arg Gly  Arg Gln Lys Val Glu  Lys Gln Val Tyr Gln  Asn Phe Glu 
    1025                 1030                 1035             


Lys Gln  Leu Ile Glu Lys Leu  Asn Tyr Leu Val Leu  Lys Glu Ser 
    1040                 1045                 1050             


Asn Val  Asp Glu Pro Gly Gly  Val Leu Arg Ala Tyr  Gln Leu Ala 
    1055                 1060                 1065             


Asn Lys  Phe Glu Thr Phe Lys  Lys Leu Gly Lys Gln  Ser Gly Ile 
    1070                 1075                 1080             


Ile Phe  Tyr Val Pro Ala Ala  Tyr Thr Ser Ala Ile  Asp Pro Val 
    1085                 1090                 1095             


Thr Gly  Tyr Ile Gln Tyr Leu  Tyr Pro Leu Lys Gln  Ala Asp Ser 
    1100                 1105                 1110             


Val Glu  Lys Ala Arg Lys Phe  Tyr Ser Gln Phe Lys  Arg Ile Ser 
    1115                 1120                 1125             


Tyr Asn  Pro His Lys Gln Trp  Phe Glu Phe Ser Phe  Asp Tyr Asn 
    1130                 1135                 1140             


Asp Phe  Asn Ile Ile Tyr His  Gly Lys Ser Ser Trp  Thr Ile Cys 
    1145                 1150                 1155             


Thr Thr  Asn Thr Glu Arg Tyr  Met Trp Asn Arg Leu  Leu Asn Asn 
    1160                 1165                 1170             


Gly His  Gly Gly Glu Glu Leu  Val Tyr Val Thr Asn  Glu Leu Glu 
    1175                 1180                 1185             


Leu Leu  Phe Gly Glu Tyr Asn  Ile Ile Tyr Gly Asp  Gly Lys Asp 
    1190                 1195                 1200             


Ile Lys  Gln Gln Ile Thr Asp  Val Gln Asp Ile Asp  Val Asp Arg 
    1205                 1210                 1215             


Thr Ala  Lys Gln Phe Tyr Lys  Arg Ile Asn Glu Leu  Leu Asn Leu 
    1220                 1225                 1230             


Thr Leu  Lys Leu Arg His Asn  Asn Gly Lys Lys Gly  Ala Asp Glu 
    1235                 1240                 1245             


Glu Asp  Tyr Ile Leu Ser Pro  Val Glu Pro Tyr Phe  Asp Ser Arg 
    1250                 1255                 1260             


Phe Glu  Ser Arg Lys Pro Ser  Met Gln Gln Thr Leu  Pro Ile Asn 
    1265                 1270                 1275             


Ala Asp  Ala Asn Gly Ala Phe  Asn Ile Ala Arg Lys  Gly Leu Leu 
    1280                 1285                 1290             


Leu Leu  Glu Arg Leu Asn Gln  Leu Gly Val Glu Glu  Phe Glu Lys 
    1295                 1300                 1305             


Thr Lys  Lys Ser Asn Asn Lys  Lys Thr Gln Trp Leu  Pro His Glu 
    1310                 1315                 1320             


Leu Trp  Val Glu Tyr Ala Gln  Asn His Thr Arg Lys  
    1325                 1330                 1335 


<210> 739
<211> 1520
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12b sequence"

<400> 739
Met Ala Tyr Gln Asn Gly Lys Glu Gln Pro Thr Val Thr Asn Gln Arg 
1               5                   10                  15      


Ala Tyr Thr Leu Arg Leu Ser Gly Thr Asn Asp Gln Asp Ser Ile Trp 
            20                  25                  30          


Arg Asn Arg Leu Trp His Thr His Glu Ala Val Asn Lys Gly Ala Lys 
        35                  40                  45              


Thr Phe Gly Asp Trp Leu Leu Thr Met Arg Gly Gly Leu Cys His Thr 
    50                  55                  60                  


Leu Ala Glu Ala Asp Val Pro Gly Lys Gly Asn Lys Pro Ala Arg His 
65                  70                  75                  80  


Pro Thr Pro Gln Glu Ile Arg Ser Arg Arg Val Val Leu Ala Leu Ser 
                85                  90                  95      


Trp Leu Ser Val Glu Ser Gln His Gly Ala Pro Glu Arg His Leu Val 
            100                 105                 110         


Ser His Asp Leu Asp Ile Ala Thr Gly Glu Arg Lys Asn Trp Lys Thr 
        115                 120                 125             


Val Glu Ala Leu Arg Glu Ile Leu His Gly Arg Cys Leu Cys Lys Glu 
    130                 135                 140                 


Leu Ile Asp Glu Trp Ala Asn Asp Cys Arg Asp Ser Leu Ser Ala Thr 
145                 150                 155                 160 


Ile Arg Glu Asp Ala Val Trp Val Asn Arg Ser Lys Ala Phe Asp Leu 
                165                 170                 175     


Ala Ala Lys Lys Ile Gly Ala Ser Leu Thr Arg Glu Glu Leu Trp Asp 
            180                 185                 190         


Phe Leu Gln Pro Phe Phe Ala Asn Lys His Gly Tyr Leu Gln Met Asp 
        195                 200                 205             


Thr Val Ala Gly Val Thr Asn Gly Asp Ser Glu Thr Asp Ala Glu Glu 
    210                 215                 220                 


Ala Lys Glu Asp Ser Ser Glu Glu Lys Ala Lys Asp Leu Ser Gln Lys 
225                 230                 235                 240 


Ala Gly Gln Trp Leu Ser Ser Arg Phe Gly Thr Gly Thr Gly Ala Asp 
                245                 250                 255     


Phe Ser Arg Phe Ser Lys Val Tyr Glu Val Leu Ala Ala Arg Cys Gly 
            260                 265                 270         


Ser Val Ala Val Gly Val Ser Gly Val Glu Ala Ile Arg Ile Leu Ala 
        275                 280                 285             


Gly Thr Leu Ala Asp Phe Ser Pro Gly Ser Asn Asp Ile Glu Gly Met 
    290                 295                 300                 


Leu Gly Leu Met Ser Gly Pro Gly Tyr Lys Ser Ala Thr Arg Asn Ile 
305                 310                 315                 320 


Leu Gln Lys Ile Asn Thr Leu Gln Thr Val Ser Gln Gln Asp Leu Asp 
                325                 330                 335     


Arg Leu Arg Glu Ala Ser Glu Lys Asp Ala Leu Gln Ser Lys Gln Lys 
            340                 345                 350         


Val Gly Gly Lys Gly Ser Arg Pro Tyr Ala Asn Ala Ile Leu Gln Asp 
        355                 360                 365             


Val Glu Ala Ala Cys Gly Ile Cys Tyr Ala Gly Thr Gly Glu Ser Pro 
    370                 375                 380                 


Ala Arg His Trp Gln Tyr Ala Val Ile Leu Asp His Ala Ala Arg Arg 
385                 390                 395                 400 


Val Ser Met Ala His Ser Trp Ile Lys Arg Ala Glu Glu Gln Arg Ser 
                405                 410                 415     


Lys Phe Glu Ile Glu Lys Asp Lys Leu Asp His Val Pro Lys Asp Ala 
            420                 425                 430         


Leu Ala Trp Leu Asp Ala Phe Cys Ala Arg Arg Ser Ser Glu Ser Gly 
        435                 440                 445             


Ala Ser Asp Ala Tyr Arg Ile Arg Arg Ser Ala Val Asp Gly Trp Lys 
    450                 455                 460                 


Gln Val Val Ala Ala Trp Ala Ala Leu Pro Pro Lys Pro Glu Asn Gln 
465                 470                 475                 480 


Gly Ser Glu Leu Leu Ser Asp Ala Glu Ser Ala Arg Ile Gln Ala Ala 
                485                 490                 495     


Arg Glu Leu Gln Asp Thr Val Glu Lys Phe Gly Asp Ile Gln Leu Phe 
            500                 505                 510         


Glu Ala Leu Ser Leu Thr Gly Ala Lys Cys Val Trp Gln Pro Asp Gly 
        515                 520                 525             


Arg Pro Asp Ala Gln Pro Leu Leu Asp Tyr Val Ala Gly Thr Asp Ala 
    530                 535                 540                 


Ile Ser Lys Lys Gln Arg Phe Lys Val Pro Ala Tyr Arg His Pro Asp 
545                 550                 555                 560 


Ala Leu Leu His Pro Val Phe Cys Asp Phe Gly Asn Ser Arg Trp Asn 
                565                 570                 575     


Ile Asn Tyr Ala Ile His Arg Ala Pro Glu Lys Leu Thr Pro Ala Gln 
            580                 585                 590         


Gln Leu Leu Glu Lys Lys Lys Ala Glu Ile Asp Lys Ala Glu Leu Thr 
        595                 600                 605             


Leu Ala Lys Ala Gly Asp Ala Ala Lys Gln Ala Asn Ile Ser Glu Lys 
    610                 615                 620                 


Ile Asn Gly Leu Arg Ala Ala Phe Ile Gln Gln Gln Glu Lys Val Ala 
625                 630                 635                 640 


Trp Leu Asn Ser Arg His Ala Met Thr Met Ser Leu Trp Asp Gly Thr 
                645                 650                 655     


His Ile Glu Asp Thr Pro Leu Ile Trp Gln Ser Lys Arg Phe Gly Ser 
            660                 665                 670         


Asp Ile Gly Gln Pro Val Glu Ala Gln Pro Leu Pro Val Ser Arg Ala 
        675                 680                 685             


Asp Arg Phe Gly Arg Ala Val Ala Leu Ala Gln Asp Asn Val Pro Val 
    690                 695                 700                 


Ile Pro Ser Gly Leu Phe Asp Leu Ser Asp Trp Asn Gly Arg Leu Gln 
705                 710                 715                 720 


Ala Pro Arg Arg Gln Leu Glu Ala Ile Ala Ala Ile Arg Asp Ser Ala 
                725                 730                 735     


Lys Leu Ser Val Asn Glu Lys Gln Gln Leu Val Ala Lys Arg Ile Gln 
            740                 745                 750         


Ser Ile Arg Trp Leu Leu Thr Phe Ser Ala Lys Leu Gln Ser His Gly 
        755                 760                 765             


Pro Phe Ile Ala Tyr Ala Ala Gln His Gly Phe Asp Trp Arg Tyr Gly 
    770                 775                 780                 


Ala His Gly Pro Glu Asn Lys Ser Arg Gln Gly Leu Ala Lys Leu Ile 
785                 790                 795                 800 


Leu Cys Arg Leu Pro Gly Leu Arg Ile Leu Ser Val Asp Leu Gly His 
                805                 810                 815     


Arg Tyr Ala Ala Ala Cys Ala Val Trp Glu Thr Leu Asn Ala Gly Gln 
            820                 825                 830         


Ile Gln Lys Ala Cys Leu Asp Ala Gly Lys Glu Ala Pro Gly Pro Cys 
        835                 840                 845             


Thr Leu Tyr Leu His Leu Lys Gln Ile Ala Asn Gly Lys Glu Lys Lys 
    850                 855                 860                 


Thr Ile Phe Arg Arg Ile Ala Ala Asp Thr Leu Pro Asp Gly Ser Pro 
865                 870                 875                 880 


His Pro Ala Pro Trp Ala Arg Leu Asp Arg Gln Phe Leu Ile Lys Leu 
                885                 890                 895     


Gln Gly Glu Asp Arg Asp Ala Arg Leu Ala Thr Ser Glu Glu Ile Ala 
            900                 905                 910         


Ala Val Glu Gln Met Glu Asn Glu Leu Gly Val Val Arg Gln Leu Lys 
        915                 920                 925             


Arg Lys Gly Arg Glu Leu Leu Val Asp Glu Leu Met Ser Asp Ala Leu 
    930                 935                 940                 


Arg Thr Leu Arg Leu Gly Leu Arg Arg His Gly Val Arg Ala Arg Ile 
945                 950                 955                 960 


Ala Phe Asn Leu Thr Ala Asn Lys Arg Ile Arg Pro Gly Gly Lys Glu 
                965                 970                 975     


Glu Val Leu Asp Gln Glu Gly Arg Val Leu Leu Leu Thr Glu Thr Leu 
            980                 985                 990         


Leu Ala Trp Tyr Glu Leu Tyr Thr  Ala Glu Arg Trp Thr  Asp Glu Pro 
        995                 1000                 1005             


Ala Arg  Glu Leu Trp Asn Arg  His Ile Gln Pro Leu  Leu Gly Ala 
    1010                 1015                 1020             


Thr Ile  Leu Gln Asn Thr Val  Asn Gln Glu Asp Thr  Pro Ser Ala 
    1025                 1030                 1035             


Ala Lys  Arg Arg Lys Leu Arg  Glu Glu Thr Ser Gly  Lys Leu Lys 
    1040                 1045                 1050             


His Val  Ala Glu Glu Ile Ala  Lys Asn Asp Ser Leu  Cys Arg Gln 
    1055                 1060                 1065             


Leu His  Val Leu Trp Ser Ala  Gln Trp Gln Thr Glu  Asp Val Ile 
    1070                 1075                 1080             


Trp Arg  Thr Arg Leu Arg Met  Met Arg Arg Trp Leu  Leu Pro Arg 
    1085                 1090                 1095             


Gly Val  Lys Arg Asn Ala Gln  Leu Arg Ile Ser Ile  Arg Asp Val 
    1100                 1105                 1110             


Gly Gly  Leu Ser Leu Thr Arg  Ile Ala Ser Phe Lys  Ser Leu Tyr 
    1115                 1120                 1125             


Gln Val  Gln Lys Ala Tyr Gln  Met Arg Pro His Pro  Glu Asp Pro 
    1130                 1135                 1140             


Arg Leu  Asn Ile Pro Glu Arg  Gly Asp Ser Arg Leu  Glu Asn Phe 
    1145                 1150                 1155             


Gly Gln  Arg Val Leu Asp Ala  Met Glu Arg Met Arg  Glu Asn Arg 
    1160                 1165                 1170             


Val Lys  Gln Leu Ala Ser Arg  Ile Ala Glu Ala Ala  Leu Gly Ile 
    1175                 1180                 1185             


Gly Gly  Glu Thr Gly Ile Ser  Ser Lys Asp Gly Ser  Gln Lys Lys 
    1190                 1195                 1200             


Arg Pro  Thr Glu Arg Ser Ser  Asp Pro Arg Phe Ala  Pro Cys His 
    1205                 1210                 1215             


Ala Val  Val Ile Glu Asp Leu  Thr His Tyr Arg Pro  Asp Glu Thr 
    1220                 1225                 1230             


Gln Thr  Arg Arg Glu Asn Arg  Gln Leu Met Ser Trp  Ser Ser Ser 
    1235                 1240                 1245             


Lys Val  Lys Lys Tyr Leu Gly  Glu Ala Cys Glu Leu  Asn Gly Leu 
    1250                 1255                 1260             


Tyr Leu  Arg Glu Val Ser Pro  Ala Tyr Thr Ser Arg  Gln Asp Ser 
    1265                 1270                 1275             


Arg Thr  Gly Ala Pro Gly Leu  Arg Cys Asn Asp Val  Thr Val Val 
    1280                 1285                 1290             


Glu Phe  Asn Asn Ser Pro Phe  Trp Arg Lys Gln Val  Gly Ala Ala 
    1295                 1300                 1305             


Glu Lys  Asn Gln Lys Glu Gly  Asn Lys Gly Asp Ala  Arg Glu Arg 
    1310                 1315                 1320             


Tyr Leu  Leu Ser Ile Glu Glu  Gly Ile Arg Gly Ala  Ala Asn Asp 
    1325                 1330                 1335             


Arg Asp  Ile Phe Arg Ile Pro  Val Lys Gly Gly Glu  Ile Phe Val 
    1340                 1345                 1350             


Ser Ala  Cys Ile Thr Asp Gly  Gly Asn Asn Ala Lys  Lys Asn Ala 
    1355                 1360                 1365             


Pro Pro  Gly Leu Gln Ala Asp  Leu Asn Ala Ala Ala  Asn Ile Gly 
    1370                 1375                 1380             


Leu Arg  Ala Ile Phe Asp Pro  Asp Trp Glu Gly Arg  Trp Trp Tyr 
    1385                 1390                 1395             


Ile Pro  Cys Asp Ala Ala Thr  Leu Cys Pro Asp Ala  Lys Lys Phe 
    1400                 1405                 1410             


Ile Gly  Cys Lys Ala Val Asp  Pro Thr Lys Pro Leu  Arg Val Val 
    1415                 1420                 1425             


Ala Glu  Glu Gly Ala Ile Ser  Ala Ser Gly Ile Gly  Ser Lys Lys 
    1430                 1435                 1440             


Ser Gly  Arg Lys Lys Asn Ala  Ala Thr Asp Gly Thr  Arg Ile Val 
    1445                 1450                 1455             


Asn Leu  Trp Arg Asp Pro Ser  Gly Ala Pro Ile His  Arg Asp Val 
    1460                 1465                 1470             


Leu Arg  Ser Pro Glu Trp Gln  Asp Tyr Ala Gly Tyr  Trp Asn Glu 
    1475                 1480                 1485             


Val Gln  His Arg Val Ile Arg  Asn Leu Lys Thr Cys  Tyr Glu Gln 
    1490                 1495                 1500             


Thr Ser  Gln Gln Glu Asp Pro  Phe Val Ser Gln Asp  Ala Asp Lys 
    1505                 1510                 1515             


Pro Phe  
    1520 


<210> 740
<211> 1180
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12b sequence"

<400> 740
Met Lys Arg Leu Ala Glu Thr Ala Leu Ala Asp Lys Val Lys Cys Glu 
1               5                   10                  15      


Thr Asn Ser Arg Pro Lys Gly Glu Arg Ala Tyr Ala Asn Ser Ile Leu 
            20                  25                  30          


His Asp Val Glu Ser Ala Cys Gly Phe Thr Tyr Arg Val Asp Lys Gly 
        35                  40                  45              


Glu Gln Pro Val Pro Val Ser Asp Tyr Ser His Tyr Ala Asn Asp Tyr 
    50                  55                  60                  


Arg Trp Gly Pro Ala Asn His Ser Glu Phe Ala Val Met Leu Asp His 
65                  70                  75                  80  


Ala Ala Arg Arg Val Ser Leu Ala His Thr Trp Ile Lys Arg Ala Glu 
                85                  90                  95      


Ala Glu Arg Arg Gln Phe Glu Glu Asn Ala Lys Lys Ile Asp Lys Val 
            100                 105                 110         


Pro Lys Val Ala Arg Glu Trp Leu Asp Ser Leu Cys Ala Glu Arg Ser 
        115                 120                 125             


Ile Val Leu Gly Ala Leu Glu Pro Tyr Arg Ile Arg Arg Arg Ala Val 
    130                 135                 140                 


Asp Gly Trp Lys His Val Val Ala Ala Trp Ser Lys Ser Asp Cys Lys 
145                 150                 155                 160 


Thr Ala Gln Asp Arg Ile Thr Ala Ala Arg Leu Leu Gln Glu Asp Pro 
                165                 170                 175     


Glu Ile Asp Lys Phe Gly Asp Ile Gln Leu Phe Glu Ala Leu Ala Glu 
            180                 185                 190         


Asp His Ala Val Cys Val Trp Gln Arg Asp Gly Glu Ala Gly Lys Thr 
        195                 200                 205             


Ser Asp Pro Gln Leu Leu Ile Asp Tyr Ala Leu Ala Ala Glu Ala Glu 
    210                 215                 220                 


Phe Lys Lys Arg His Phe Lys Val Pro Ala Tyr Arg His Pro Glu Ala 
225                 230                 235                 240 


Phe Trp His Pro Val Phe Cys Asp Phe Gly Gln Ser Arg Trp Lys Ile 
                245                 250                 255     


Cys Phe Asp Val His Lys Asn Arg Gln Ser Arg Arg Gln Arg Ala Cys 
            260                 265                 270         


Ala Asn Arg Ile Ser Arg Lys Ile Cys Phe Asp Val His Lys Lys Arg 
        275                 280                 285             


Gln Thr Leu Arg Leu Ser Leu Glu Val Trp Thr Gly Ser Lys Met Leu 
    290                 295                 300                 


Asp Met Pro Leu Cys Trp Gln Cys Lys Arg Leu Ala Arg Asp Leu Ala 
305                 310                 315                 320 


Leu Gly Gln Asp His Lys Lys Asp Arg Ser Cys Gln Val Thr Arg Ala 
                325                 330                 335     


Asp Arg Leu Gly Arg Ala Val Ser Asn Val Ala Arg Asn Gln Glu Val 
            340                 345                 350         


Gln Ile Leu Gly Leu Phe Glu Gln Glu Tyr Trp Asn Gly Arg Leu Gln 
        355                 360                 365             


Ala Pro Arg Pro Gln Leu Glu Ala Leu Gly Arg Tyr Ile Glu Lys His 
    370                 375                 380                 


Gly Trp Asp Ala Lys Ala Gln Lys Ser Cys Arg Ala Ile Arg Trp Met 
385                 390                 395                 400 


Ile Ser Phe Ser Pro Arg Leu Gln Pro Ala Gly Pro Trp Gly Lys Phe 
                405                 410                 415     


Ala Glu Lys Leu Gln Leu Asn Pro Asn Pro Lys Tyr Trp Pro His Ala 
            420                 425                 430         


Glu Asp Asn Lys Asp Arg Gly Ser Arg Ser Lys Leu Ile Leu Cys Arg 
        435                 440                 445             


Leu Pro Gly Leu Arg Val Leu Ser Val Asp Leu Gly His Arg Tyr Ala 
    450                 455                 460                 


Ala Ala Cys Ala Val Trp Glu Ala Val Asp Ala Glu Gln Val Lys Glu 
465                 470                 475                 480 


Ala Cys Gln Ala Ala Gly His Arg Glu Pro Asn Glu Asn Asp Leu Tyr 
                485                 490                 495     


Leu His Leu Lys Lys Arg Thr Thr Lys Gln Lys Lys Gly Ser Gln Gly 
            500                 505                 510         


Val Val Glu Glu Thr Thr Ile Tyr Arg Arg Ile Gly Ala Asp Thr Leu 
        515                 520                 525             


Pro Asp Cys Thr Pro His Pro Ala Pro Trp Ala Arg Leu Asp Arg Gln 
    530                 535                 540                 


Phe Leu Ile Arg Leu Gln Gly Glu Glu Asp Glu Ala Arg Ala Ala Ser 
545                 550                 555                 560 


Asn Glu Glu Val Trp Ala Val His Lys Leu Glu Ala Glu Leu Gly Arg 
                565                 570                 575     


Thr Ile Pro Leu Ile Asp Arg Leu Leu Gly Ala Gly Trp Gly Gln Thr 
            580                 585                 590         


Glu Lys Gln Lys Ala Arg Leu Lys Ala Leu Arg Glu Leu Gly Trp Thr 
        595                 600                 605             


Pro Ala Asn Lys Cys Gln Ala Phe Asn Ser Thr Asp Glu Thr Glu Leu 
    610                 615                 620                 


Arg Arg Pro Ser Leu Ala Val Asp Glu Leu Met Leu Asp Ala Val Gly 
625                 630                 635                 640 


Thr Leu Arg Leu Ala Leu Lys Arg His Gly Asp Arg Ala Arg Ile Ala 
                645                 650                 655     


Arg Tyr Leu Ile Thr Asp Glu Arg Thr Lys Pro Gly Gly Val Lys Glu 
            660                 665                 670         


Lys Leu Asp Glu Asn Gly Arg Ile Glu Leu Leu Gln Asp Ala Leu Ile 
        675                 680                 685             


Ile Trp His Gly Leu Phe Ser Ser Pro Arg Trp Arg Asp Asp Ala Ala 
    690                 695                 700                 


Lys Gln Leu Trp Asn Glu His Ile Ala Lys Leu Val Gly Glu Gln Asn 
705                 710                 715                 720 


Leu Val Glu Val Ser Glu Asp Ala Ser Gly Ser Glu Arg Arg Thr Lys 
                725                 730                 735     


Gln Lys Gln Asn Arg Glu Lys Leu Arg Glu Ala Ala Lys Ala Leu Val 
            740                 745                 750         


Asp Asp Val Ala Leu Arg Gln Ala Leu His Asp Met Trp Lys Arg Arg 
        755                 760                 765             


Trp Glu Glu Glu Asp Arg Glu Trp Arg Arg Arg Leu Arg Trp Phe Lys 
    770                 775                 780                 


Asp Trp Val Leu Pro Arg Arg Glu Gln Ala Arg Lys Ala Tyr Ser Arg 
785                 790                 795                 800 


Pro Ala Glu Thr Gly Ser Ser Ser His Pro Lys Arg Arg Ala Arg Tyr 
                805                 810                 815     


Ala Ala Ile Arg Arg Val Gly Gly Leu Ser Leu Thr Arg Leu Ala Thr 
            820                 825                 830         


Leu Thr Glu Phe Arg Arg Lys Val Gln Val Gly Phe Phe Thr Arg Leu 
        835                 840                 845             


Lys Pro Asp Gly Thr Lys Ala Glu Ala Lys Glu Gly Phe Gly Gln Ser 
    850                 855                 860                 


Thr Leu Asp Ala Leu Glu His Leu Arg Ala Gln Arg Val Lys Gln Leu 
865                 870                 875                 880 


Ala Ser Arg Ile Val Glu Ala Ala Leu Gly Val Gly Arg Ile Arg Arg 
                885                 890                 895     


Phe Pro Gly Val Lys Asn Pro Lys Arg Pro Asp Thr Pro Val Asp Lys 
            900                 905                 910         


Pro Cys His Ala Ile Val Ile Glu Asn Leu Thr His Tyr Arg Pro Glu 
        915                 920                 925             


Glu Thr Arg Thr Arg Arg Glu Asn Arg Gln Leu Met Thr Trp Ser Ser 
    930                 935                 940                 


Ser Lys Ile Lys Lys Tyr Leu Ala Glu Ala Cys Gln Leu Tyr Gly Leu 
945                 950                 955                 960 


His Leu Arg Glu Val Thr Ala Ala Tyr Thr Ser Arg Gln Asp Ser Arg 
                965                 970                 975     


Thr Gly Ala Pro Gly Leu Arg Cys Gln Asp Val Pro Val Lys Glu Phe 
            980                 985                 990         


Met Arg Ser Leu Phe Trp Arg Lys  Glu Val Ala Gln Ala  Glu Lys Lys 
        995                 1000                 1005             


Leu Thr  Ala Gly Lys Gly Ser  Ser Tyr Glu Arg Leu  Leu Cys Glu 
    1010                 1015                 1020             


Leu Asn  Gln Arg Trp Lys Asp  Asn Ser Pro Gly Asp  Gly Lys Arg 
    1025                 1030                 1035             


Ala Glu  Leu Leu Arg Leu Pro  His Lys Gly Gly Glu  Ile Phe Val 
    1040                 1045                 1050             


Ser Ala  Ala Pro Asp Ser Pro  Ala Ala Arg Gly Leu  Gln Ala Asp 
    1055                 1060                 1065             


Leu Asn  Ala Ala Ala Asn Ile  Gly Leu Arg Ala Leu  Thr Asp Pro 
    1070                 1075                 1080             


Asp Trp  Pro Gly Lys Trp Trp  His Val Pro Cys Asn  Ala Val Thr 
    1085                 1090                 1095             


Phe Arg  Pro Val Glu Asp Lys  Val Lys Gly Ser Ala  Ala Val Lys 
    1100                 1105                 1110             


Leu Asp  Gln Ser Leu Arg Gln  Val Ala His Pro Gln  Ser Lys Asp 
    1115                 1120                 1125             


Pro Gly  Ala Lys Lys Ser Lys  Glu Ile Val Asn Leu  Trp Cys Asp 
    1130                 1135                 1140             


Ile Ser  Ser Leu Pro Leu Glu  His Arg Glu Trp Lys  Leu Asp Trp 
    1145                 1150                 1155             


Glu Pro  Tyr Pro Ala Tyr Trp  Asn Asn Val Gln Cys  Arg Val Ile 
    1160                 1165                 1170             


Arg Val  Leu Gln Gly Lys Val  
    1175                 1180 


<210> 741
<211> 1546
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Cas12b sequence"

<400> 741
Met Ala Asn Ala Lys Val Lys Thr Thr Thr Arg Ser Tyr Thr Leu Ser 
1               5                   10                  15      


Leu Asn Ala Pro Ser Asp Thr Thr Asp Arg Ser Pro Leu Trp His Arg 
            20                  25                  30          


Ile Phe Arg Thr His Tyr Ala Ile Cys Cys Gly Ala Arg Glu Phe Gly 
        35                  40                  45              


Lys Leu Leu Leu Asp Leu Arg Gly Gly Leu Pro Thr Ser Leu Ala Gln 
    50                  55                  60                  


Leu Gly Glu Gly Ile Ala Glu Asn Asp Arg Arg Gln Thr Gln Arg Gly 
65                  70                  75                  80  


Thr Arg Arg Ile Leu Ala Leu Gly Trp Leu Ser Val Glu Asp Leu Asp 
                85                  90                  95      


His Ala Arg Asn Asp Pro His Arg Val Gln Asp Thr Ala Pro Gly Ser 
            100                 105                 110         


Pro Leu Asp Gln Asp Leu Ala Glu Lys Ile Leu Arg Lys Ile Leu Ile 
        115                 120                 125             


Thr Lys Gly Ile Lys Ser Glu Glu Glu Gln Ser Asn Trp Ile Ser Asp 
    130                 135                 140                 


Cys Leu Pro Ala Leu Thr Ala Asn Ile Arg Pro Asp Ala Val Trp Val 
145                 150                 155                 160 


Asn Arg Ala Glu Ser Phe Ala Gln Trp Gln Arg Gly Thr Gln Pro Gly 
                165                 170                 175     


Ala Gln Pro Pro Thr Pro Glu Glu Ala Gln Gln Ile Leu Phe Ser Leu 
            180                 185                 190         


Cys Gly Glu Ser Leu Val Thr Leu Thr Leu Pro Glu Gln Pro Ala Ala 
        195                 200                 205             


Ala Gly Gln Lys Gln Pro Asp Gln Glu Thr Ser Pro Asp Pro Glu Glu 
    210                 215                 220                 


Gln Thr Asp Arg Pro Pro Ala Ala Pro Ser Ala Asp Asp Glu Met Asp 
225                 230                 235                 240 


Pro Ser Asn Ala Ser Arg Gly Ile Phe Gly Asp Leu Phe Gly Glu Asn 
                245                 250                 255     


Ala Glu Gly Lys Arg Ser Arg Ser Gln Gly Lys Asp Asn Phe Ala Cys 
            260                 265                 270         


Ala Val Arg Asp Phe Leu Cys Ala Asn Pro Thr Pro Ser Ala Asp Ala 
        275                 280                 285             


Ile Thr Glu Phe Arg Glu Lys Gln Lys Pro Arg Glu Pro Asn Pro Pro 
    290                 295                 300                 


Gly Pro Glu Lys Tyr Pro Pro Glu Val Ser Thr Ser Gly Ala Pro Thr 
305                 310                 315                 320 


Ala Val Ala Lys Arg Tyr Arg Lys Leu Leu Val Cys Ala Gly Leu Trp 
                325                 330                 335     


Pro Lys Ser Ala Asp Glu Asp Gly Ser Ser Arg Asn Ser Ala Lys Thr 
            340                 345                 350         


Lys Phe Ala Asp Pro Lys Glu Pro Gln Lys Thr Glu Ile Gln Ile Asn 
        355                 360                 365             


Ala Leu Asp Leu Ile Asp Ala Cys Asn Gln Ala Ala Pro Ala Asp Asp 
    370                 375                 380                 


Ser Gly Thr Ser Pro Lys Ala Gly Arg Val Phe Ala Pro Ala Trp Ala 
385                 390                 395                 400 


Ser Asn Ile Ala Glu Lys Val Ala Ser Ala Thr Gln Met Pro Ala Asn 
                405                 410                 415     


Ala Lys Ser Leu Asn Glu Phe Lys Arg Leu Met Phe Ala Leu Ala Ala 
            420                 425                 430         


Arg Arg Phe Ser Gln Thr Gln Ser Trp Thr Arg Arg Asn Glu Ala Glu 
        435                 440                 445             


Arg His Met Ala Ala Ala Arg Gln Asp Ala Ala Val Ala Arg Leu Arg 
    450                 455                 460                 


Glu Ile Asp Pro Asp His Lys Ala Gln Asp Trp Leu Arg Gly Tyr Glu 
465                 470                 475                 480 


Gln Arg Arg Ala Asp Gln Ser Gly Ser Asn Gly Glu Phe Arg Ile Thr 
                485                 490                 495     


Arg Arg Met Ile Gly Glu Ala Glu Ala Val Phe Lys Ala Trp Ala Gly 
            500                 505                 510         


Thr Asn Ser Ala Ala Glu Arg Glu Leu Lys Thr Val Ala Val Gln Thr 
        515                 520                 525             


Thr Ala Glu Lys Phe Gly Asp Ala Ala Leu Tyr Ser Glu Ile Ala Arg 
    530                 535                 540                 


Asn Thr Ala Ala Glu Ala Val Trp Arg Ser Gly Ser Ala Pro Glu Ile 
545                 550                 555                 560 


Leu Asp Gln Trp Val Lys Leu Arg Lys Ala Gln Ser Asp Gln Gln Arg 
                565                 570                 575     


Thr Arg Val Pro Arg Phe Cys His Pro Asn Ala Phe Arg His Pro Thr 
            580                 585                 590         


Trp Cys Glu Phe Gly Glu Ser Ser Lys Pro Gly Val Trp Tyr Ala Trp 
        595                 600                 605             


Asn Pro Lys Ser Lys Pro Arg Lys Pro Glu Val Gly Gly Glu Gly Asp 
    610                 615                 620                 


Gly Thr Arg Arg Leu Trp Val Leu Leu Pro Asp Phe Asn Ser Gly Ile 
625                 630                 635                 640 


Gly Gln Ala Val Pro Leu Arg Trp Arg Ser Lys Arg Leu Ser Lys Asp 
                645                 650                 655     


Leu Gly Glu Ala Leu Gln Pro Ser Asp Ala Pro Ile Pro Arg Ala Asp 
            660                 665                 670         


Arg Val Ser Ile Ala Ala Ala Gly Leu Asn Leu Glu Gly Ala Asn Gly 
        675                 680                 685             


Val Pro Ala Arg Tyr Arg Pro Ser Leu Pro Phe Ser Glu Asn Thr Lys 
    690                 695                 700                 


Gly Trp Asn Ala Arg Leu Gln Ala Asn Arg Thr Ala Leu Leu His Leu 
705                 710                 715                 720 


Glu Ser Lys Trp Asp Ala Glu Ala Ala Thr Trp Arg Asp Gly Gly Arg 
                725                 730                 735     


Ser Leu Leu Ala Leu Lys Trp Phe Thr Thr Phe Ser Pro Glu Leu Ala 
            740                 745                 750         


Met Ser Glu Gly Pro Gly Arg Ala Ile His Pro Lys Leu Gly Trp Asn 
        755                 760                 765             


Ser Glu Pro His Ser Asp Leu Asn Arg Ala Gln Lys Arg Gly Gly Asn 
    770                 775                 780                 


Ala Lys Leu Ile Leu Ser Arg Leu Pro Gly Leu Arg Val Leu Ser Val 
785                 790                 795                 800 


Asp Leu Gly His Arg Tyr Ala Ala Ala Cys Ala Val Trp Glu Thr Leu 
                805                 810                 815     


Thr Thr Glu Gln Met Asn Ala Ala Cys Gln Ala Lys Asn His Thr Gln 
            820                 825                 830         


Pro Ala Glu Ser Asp Met Tyr Val His Leu Ala His Pro Thr Glu Arg 
        835                 840                 845             


Val Val Lys Ser Gly Arg Lys Lys Gly Gln Asn Leu Ile Gln Thr Thr 
    850                 855                 860                 


Val Tyr Arg Arg Ile Ala Ala Asp Thr Leu Pro Asp Gly Thr Pro His 
865                 870                 875                 880 


Pro Ala Pro Trp Gly Arg Leu Asp Arg Gln Phe Leu Ile Lys Leu Gln 
                885                 890                 895     


Gly Glu Gln Arg Pro Thr Arg Ala Ala Ser Lys Asn Glu Ala Asp Leu 
            900                 905                 910         


Ala Asn Ala Leu Phe His Arg Leu Gly Leu Arg Ser Asp Ala Asp Ser 
        915                 920                 925             


Glu Asn Lys Ser Arg Ala Val Asp Lys Leu Met Ala Arg Thr Val Arg 
    930                 935                 940                 


Val Ala Thr Leu Gly Leu Lys Arg His Ala Arg Arg Ala Lys Ile Ala 
945                 950                 955                 960 


Tyr Ala Leu Asp Pro Asn Thr Lys Ala Ile Pro Gly Met Gly Gly Ser 
                965                 970                 975     


Ser Ala Ala Phe Thr Pro Gly Asp Glu Pro His Ile His Leu Leu Thr 
            980                 985                 990         


Asp Ala Leu Phe Asp Trp Gln Ser  Leu Ala Thr Asp Ala  Lys Trp Asp 
        995                 1000                 1005             


Asp Ala  His Ala Arg Ser Leu  Trp Asn His His Ile  Ala Thr Leu 
    1010                 1015                 1020             


Pro Gly  Gly Phe His Leu Glu  Asn Pro Thr Pro Arg  Asp Glu Ser 
    1025                 1030                 1035             


Ala His  Glu Pro Ser Arg Gln  Arg Gln Arg Ser Gly  Asp Asp Ala 
    1040                 1045                 1050             


Leu Arg  Ala Thr Leu Lys Pro  Ile Ala Glu Lys Leu  Ser Lys Ala 
    1055                 1060                 1065             


Asp Arg  Gln Glu Val His Ala  Ala Trp Lys Lys Tyr  Trp Gly Asp 
    1070                 1075                 1080             


Ser Asp  Gly Gln Ser Ala Ile  Val Pro Lys Val Leu  Gln Gly Gln 
    1085                 1090                 1095             


Arg Gly  Pro Glu Lys Thr Thr  Pro Ser Ala Ser Ala  Ser Gly Trp 
    1100                 1105                 1110             


His Gly  Lys Ile Arg Trp Ile  Thr Asp Trp Ile Met  Gly Lys Tyr 
    1115                 1120                 1125             


Leu Glu  Gly Cys Thr Gly His  Ala Trp Lys His Asp  Val Gly Gly 
    1130                 1135                 1140             


Leu Ser  Val Ser Arg Ile Thr  Thr Met Lys Ser Leu  Tyr Gln Leu 
    1145                 1150                 1155             


His Lys  Ala Phe Ala Met Arg  Ala Thr Pro Glu Lys  Pro Arg Gly 
    1160                 1165                 1170             


Ala Pro  Glu Lys Gly Glu Ser  Asn Leu Gly Ala Ala  Gln Gly Ile 
    1175                 1180                 1185             


Leu Thr  Ala Met Glu Ser Met  Arg Gln Gln Arg Val  Lys Gln Leu 
    1190                 1195                 1200             


Ala Ser  Arg Ile Ala Glu Ala  Ala Leu Gly Ala Gly  Ile Glu Arg 
    1205                 1210                 1215             


Arg Ser  Asp Asn Gly Arg Glu  Leu Gln Arg Pro Arg  Glu Arg Val 
    1220                 1225                 1230             


Asp Asp  Pro Arg Phe Ala Ala  Cys His Ala Val Val  Val Glu Asp 
    1235                 1240                 1245             


Leu Thr  Asn Tyr Arg Pro Asp  Glu Met Gln Thr Arg  Arg Glu Asn 
    1250                 1255                 1260             


Arg Gln  Leu Met Gln Trp Ala  Ser Ser Lys Val Lys  Lys Tyr Leu 
    1265                 1270                 1275             


Ser Glu  Ala Cys Gln Leu His  Gly Leu Tyr Leu Arg  Gly Val Pro 
    1280                 1285                 1290             


Ala Gly  Tyr Thr Ser Arg Gln  Asp Ser Arg Thr Gly  Ala Pro Gly 
    1295                 1300                 1305             


Val Arg  Cys Gly Asp Ile Pro  Val Glu Glu Leu Met  Ala Ala Pro 
    1310                 1315                 1320             


Arg Trp  Arg Arg Gln Ile Leu  Thr Ala Glu Lys Thr  Arg Arg Glu 
    1325                 1330                 1335             


Asn Asn  Thr Gly Thr Ala Arg  Asp Arg Tyr Ile Leu  Thr Leu Asp 
    1340                 1345                 1350             


Glu Lys  Tyr Arg Leu Leu Thr  Ala Glu Gln Arg Lys  Lys Thr Pro 
    1355                 1360                 1365             


Pro Ala  Arg Ile Pro Val Lys  Gly Gly Asp Leu Phe  Val Ser Ala 
    1370                 1375                 1380             


Asp Pro  Asp Ser Pro Ala Ala  Ser Gly Ile Gln Ala  Asp Leu Asn 
    1385                 1390                 1395             


Ala Ala  Ala Asn Ile Gly Leu  Lys Ala Leu Ile Asp  Pro Asp Trp 
    1400                 1405                 1410             


Pro Gly  Arg Trp Trp Tyr Ile  Pro Cys Asp Ala Thr  Thr His Lys 
    1415                 1420                 1425             


Pro Ser  Pro Glu Arg Thr Arg  Gly Ser Ala Ala Val  Asp Cys Asp 
    1430                 1435                 1440             


Val Pro  Leu Gly Pro Asp Ser  Thr Gly Thr Pro Glu  Asp Arg Asp 
    1445                 1450                 1455             


Ala Lys  Pro Lys Lys Asn Gln  Arg Asn Ser Lys Ile  Ala Gly Arg 
    1460                 1465                 1470             


Gly Gln  Ser Ala Ile Ile Asn  Leu Trp Arg Asp Pro  Thr His Leu 
    1475                 1480                 1485             


Pro Ile  Lys Glu Asn Pro Ser  Ala Trp Cys Glu Ser  Lys Lys Tyr 
    1490                 1495                 1500             


Trp Asn  Gln Val Glu His Asn  Val Val Lys Val Ile  Glu Ser Lys 
    1505                 1510                 1515             


Gly Gln  Lys Leu Thr Gln Thr  Ala Glu Ala Ala Thr  Gly Glu Ser 
    1520                 1525                 1530             


Ala Ser  Ser Pro Pro Ile Ala  Pro Thr Asp Val Pro  Trp 
    1535                 1540                 1545     


<210> 742
<211> 112
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 742
gtctagagga cagaattttt caacgggtgt gccaatggcc actttccagg tggcaaagcc       60

cgttgagctt ctcaaatctg agaagtggca cagtggagga gtgtcttttc aa              112


<210> 743
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 743
aauuucuacu auuguagauc uccugcuaga auggcuggca auggc                       45


<210> 744
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 744
gcttctacgc agaaggga                                                     18


<210> 745
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 745
gtgacagttt ggccttgt                                                     18


<210> 746
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 746
ctactgctgc ctggagttga attcctcttc tcgttcctca tc                          42


<210> 747
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 747
gctttgctgc tgcttgacag tgttgttggc ctttacca                               38


<210> 748
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 748
cttgaactgt tgcgactacg t                                                 21


<210> 749
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 749
attgaaccag cttgagagca aa                                                22


<210> 750
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 750
ttgatgagct ggagcca                                                      17


<210> 751
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 751
caccctcaat gcagagtc                                                     18


<210> 752
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 752
gtgtgaccct gaagactcgg ttttagccac tgactcggat c                           41


<210> 753
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 753
cctccgtgat atggctcttc gtttttttct tacatggctc tggtc                       45


<210> 754
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 754
atgtggatgg ctgagttgtt                                                   20


<210> 755
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 755
ggcatgctga gtactggacc tc                                                22


<210> 756
<211> 7
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 756
ccccccc                                                                  7


<210> 757
<211> 7
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 757
ttttttt                                                                  7


<210> 758
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 758
caatttgccc ccagcgcttc agcgttct                                          28


<210> 759
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 759
aaagtgtgct tttccatcat gacaaatg                                          28


<210> 760
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 760
gtgtgctttt ccatcatgac aaatggca                                          28


