                         SEQUENCE LISTING

<110>  Amplyx Pharmaceuticals, Inc.
       Novartis AG
 
<120>  DOSING OF POLYOMAVIRUS NEUTRALIZING ANTIBODIES

<130>  AMPX-003/01WO

<150>  US 63/038,433
<151>  2020-06-12

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  362
<212>  PRT
<213>  Human polyomavirus 1

<400>  1

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Glu Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Lys Gln Gly Gln Leu Gln Thr Lys Met Leu 
        355                 360         


<210>  2
<211>  362
<212>  PRT
<213>  Human polyomavirus 1

<400>  2

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asp Asn Leu Arg 
    50                  55                  60                  


Gly Tyr Ser Leu Lys Leu Thr Ala Glu Asn Ala Phe Asp Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Lys Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro 
    130                 135                 140                 


Val Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Gln Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Tyr Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Lys Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Gln Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Arg Gln Gly Gln Leu Gln Thr Lys Met Val 
        355                 360         


<210>  3
<211>  362
<212>  PRT
<213>  Human polyomavirus 1

<400>  3

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asp His Leu Arg 
    50                  55                  60                  


Gly Tyr Ser Gln His Leu Ser Ala Glu Asn Ala Phe Asp Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Lys Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro 
    130                 135                 140                 


Val Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Gln Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Lys Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Tyr Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Lys Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Gln Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Arg Gln Gly Gln Leu Gln Thr Lys Met Val 
        355                 360         


<210>  4
<211>  362
<212>  PRT
<213>  Human polyomavirus 1

<400>  4

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asn Asp Leu Arg 
    50                  55                  60                  


Gly Tyr Ser Leu Arg Leu Thr Ala Glu Thr Ala Phe Asp Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Val Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Tyr Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Pro Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Gln Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Arg Gln Gly Gln Leu Gln Thr Lys Met Val 
        355                 360         


<210>  5
<211>  354
<212>  PRT
<213>  Human polyomavirus 2

<400>  5

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Lys Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Thr Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Val Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Arg Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - heavy CDR1 from MAU868 monoclonal antibody

<400>  6

Gly Phe Thr Phe Asn Asn Tyr Trp Met Thr 
1               5                   10  


<210>  7
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - heavy CDR2 from MAU868 monoclonal antibody

<400>  7

Asn Ile Lys Lys Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - heavy CDR3 from MAU868 monoclonal antibody

<400>  8

Val Arg Ser Gly Arg Tyr Phe Ala Leu Asp Asp 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - light CDR1 from MAU868 monoclonal antibody

<400>  9

Gly Gly Asp Asn Ile Gly Ser Arg Pro Val His 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - light CDR2 from MAU868 monoclonal antibody

<400>  10

Asp Asp Ser Asn Arg Pro Ser 
1               5           


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - light CDR3 from MAU868 monoclonal antibody

<400>  11

Gln Val Trp Ser Ser Ser Thr Asp His Pro 
1               5                   10  


<210>  12
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - heavy chain variable region from MAU868 monoclonal 
       antibody

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Lys Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Val Arg Ser Gly Arg Tyr Phe Ala Leu Asp Asp Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  13
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - light chain variable region from MAU868 monoclonal 
       antibody

<400>  13

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Ser Arg Pro Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Ile Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Ser Ser Ser Thr Asp His 
                85                  90                  95      


Pro Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


