                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Weiner, David
       Patel, Ami
 
<120>  CORONAVIRUS DISEASE 2019 (COVID-19) COMBINATION VACCINE

<130>  206194-0043-00WO

<150>  US 63/036,696
<151>  2020-06-09

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  3783
<212>  DNA
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, Spike

<400>  1
agccagtgtg tgaacctgac caccagaaca cagctgcctc ctgcctacac caacagcttc       60

accagaggag tctactaccc agacaaagtc ttcagaagct ctgtgctgca cagcacccag      120

gacctgttcc tgcctttctt cagcaacgtg acctggttcc acgccatcca cgtgtctggc      180

accaacggca ccaagagatt tgacaaccct gttcttcctt tcaatgatgg cgtgtacttt      240

gccagcacag agaagagcaa catcatccga ggctggatct ttggcaccac cctggacagc      300

aaaacccaga gcctgctgat cgtgaacaac gccaccaacg tggtcatcaa ggtgtgtgag      360

ttccagttct gcaatgaccc tttcctgggc gtgtactacc acaagaacaa caagtcctgg      420

atggagtctg agttcagagt ctacagctct gccaacaact gcacatttga atatgtgtcc      480

cagcctttcc tgatggacct ggagggcaag cagggcaact ttaagaacct gagagaattt      540

gtgttcaaga acatcgatgg ctacttcaag atctacagca agcacacacc catcaacctg      600

gtgagagacc tgcctcaggg cttctctgcc ctggagcctc tggtggacct gcccatcggc      660

atcaacatca ccagattcca gaccctgctg gccctgcaca gaagctacct gaccccagga      720

gacagcagca gcggctggac agctggagct gctgcctact acgtgggcta cctgcagccc      780

aggaccttcc tgctgaagta caacgaaaat ggcaccatca cagatgctgt tgactgtgcc      840

ctggaccctc ttagcgagac caagtgcacc ctgaagtcct tcacagtgga gaaaggcatc      900

taccagacca gcaacttccg agtgcagcca acagagagca tcgtgagatt tccaaacatc      960

accaacctgt gcccttttgg agaagtcttc aatgccacca gatttgcttc tgtgtacgcc     1020

tggaacagaa aaagaatcag caactgtgtg gctgactact ctgtgctgta caactctgcc     1080

tccttctcca ccttcaagtg ctatggagtc tctccaacca agctgaatga cctgtgcttc     1140

accaacgtgt atgctgacag ctttgtgatc agaggagatg aagtgcggca gattgctcct     1200

ggccagacag gcaagattgc tgactacaac tacaagctgc ctgatgactt cacaggctgt     1260

gtcatcgcct ggaacagcaa caacctggac agcaaggtgg gcggcaacta caactacctg     1320

tacagacttt tcaggaagag caacctgaag ccttttgaaa gagacatctc cacagagatc     1380

taccaggctg gcagcacacc ctgcaatggt gtggaaggct tcaactgcta cttccctctg     1440

cagagctacg gcttccagcc aacaaatggc gtgggctacc agccttacag agtggtggtg     1500

ctgtcctttg agctgctgca cgcccctgcc acagtgtgtg gccccaagaa gagcaccaac     1560

ctggtgaaga acaaatgtgt gaacttcaat ttcaatggcc tgacaggcac aggagtgctg     1620

acagagagca acaagaagtt tcttcctttc cagcagtttg gaagagacat tgctgacacc     1680

acagatgctg tgagagatcc tcagaccctg gagatcctgg atatcacacc ctgctccttt     1740

ggaggagttt ctgtcatcac acctggcacc aataccagca accaagtggc tgtgctgtac     1800

caagatgtga attgcacaga agtgcctgtg gccatccacg ctgaccagct gacacccacc     1860

tggagagtgt acagcacagg cagcaatgtt ttccagacaa gagctggctg cctgattgga     1920

gcagagcacg tgaacaacag ctatgaatgt gacatcccta ttggagctgg catctgtgcc     1980

agctaccaga cccaaaccaa cagcccaaga agagccagat ctgtggccag ccagagcatc     2040

atcgcctaca ccatgagcct gggagctgag aactctgtgg cctacagcaa caacagcatc     2100

gccatcccca ccaacttcac catctctgtg accacagaga tcctgcctgt gtccatgacc     2160

aagacatctg tggactgcac catgtacatc tgtggagaca gcacagaatg cagcaacctg     2220

ctgctgcagt acggctcctt ctgcacccag ctgaacagag ccctgacagg catcgctgtg     2280

gagcaggaca agaacacaca ggaagtgttt gcccaggtga agcagatcta caaaacacca     2340

cccatcaagg actttggagg cttcaatttc tcccaaatcc tgcctgaccc cagcaagcct     2400

tccaagagaa gcttcattga agacctgctg ttcaacaaag tgaccctggc tgatgctggc     2460

ttcatcaagc agtatggaga ctgcctggga gacattgctg ccagagacct gatctgtgcc     2520

cagaagttta atggcctgac tgtgctgcct cctctgctga cagatgaaat gatcgcccag     2580

tacacatctg ccctgctggc tggcaccatc accagtggct ggacatttgg agctggagct     2640

gccctgcaga tcccttttgc catgcagatg gcctacagat ttaatggcat cggcgtgacc     2700

cagaacgtgc tgtacgagaa ccagaagctg atcgccaacc agttcaactc tgccatcggc     2760

aagatccagg acagcctgag cagcacagcc tctgccctgg gcaagctgca ggatgtggtg     2820

aaccaaaacg cccaggccct gaacaccctg gtgaagcagc tgagcagcaa ctttggagcc     2880

atctcctctg tgctgaatga catcctgagc cggctggaca aggtggaagc agaagtgcag     2940

atcgacagac tcatcacagg ccgcctgcag agcctgcaga cctacgtgac ccagcagctg     3000

atcagagctg ctgagatccg ggcctctgcc aacctggctg ccaccaagat gtcagaatgt     3060

gtgctgggcc agagcaaaag agtggacttc tgtggcaaag gctaccacct gatgtccttc     3120

cctcagtctg ctcctcacgg cgtggtgttc ctgcacgtga cctacgtgcc tgcccaggag     3180

aagaacttca ccacagctcc tgccatctgc cacgatggca aggcccactt cccaagagaa     3240

ggtgtctttg tgtccaatgg cacccactgg ttcgtgaccc agagaaactt ctacgagcct     3300

cagatcatca ccacagacaa cacatttgtg tctggcaact gtgatgtggt catcggcatc     3360

gtgaacaaca cagtttatga ccctctgcag cctgagctgg acagcttcaa agaagagctg     3420

gacaagtact tcaagaacca cacatctcca gatgtggacc tgggagacat ctctggcatc     3480

aatgcctctg tggtgaacat ccagaaggaa attgacaggc tgaacgaagt ggccaagaac     3540

ctgaacgaaa gcctcatcga cctgcaggag ctgggcaagt acgagcagta catcaagtgg     3600

ccttggtaca tctggctggg cttcatcgct ggcctcatcg ccatcgtgat ggtgaccatc     3660

atgctgtgct gcatgaccag ctgctgctct tgcctgaagg gctgctgcag ctgtggcagc     3720

tgctgcaagt ttgatgaaga tgactctgag cctgtgctga agggcgtgaa gctgcactac     3780

aca                                                                   3783


<210>  2
<211>  1261
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, Spike

<400>  2

Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
1               5                   10                  15      


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
            20                  25                  30          


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
        35                  40                  45              


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
    50                  55                  60                  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
65                  70                  75                  80  


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
                85                  90                  95      


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
            100                 105                 110         


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
        115                 120                 125             


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
    130                 135                 140                 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
145                 150                 155                 160 


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
                165                 170                 175     


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
            180                 185                 190         


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
        195                 200                 205             


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
    210                 215                 220                 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
225                 230                 235                 240 


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
                245                 250                 255     


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
            260                 265                 270         


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
        275                 280                 285             


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
    290                 295                 300                 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
305                 310                 315                 320 


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
                325                 330                 335     


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
            340                 345                 350         


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        355                 360                 365             


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    370                 375                 380                 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                405                 410                 415     


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            420                 425                 430         


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
        435                 440                 445             


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
    450                 455                 460                 


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
465                 470                 475                 480 


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
                485                 490                 495     


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
            500                 505                 510         


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
        515                 520                 525             


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
    530                 535                 540                 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
545                 550                 555                 560 


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
                565                 570                 575     


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
            580                 585                 590         


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
        595                 600                 605             


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
    610                 615                 620                 


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
625                 630                 635                 640 


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
                645                 650                 655     


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala 
            660                 665                 670         


Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
        675                 680                 685             


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
    690                 695                 700                 


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
705                 710                 715                 720 


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
                725                 730                 735     


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
            740                 745                 750         


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
        755                 760                 765             


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
    770                 775                 780                 


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
785                 790                 795                 800 


Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
                805                 810                 815     


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
            820                 825                 830         


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
        835                 840                 845             


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
    850                 855                 860                 


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
865                 870                 875                 880 


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
                885                 890                 895     


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
            900                 905                 910         


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
        915                 920                 925             


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
    930                 935                 940                 


Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala 
945                 950                 955                 960 


Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu 
                965                 970                 975     


Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu 
            980                 985                 990         


Gln Thr Tyr Val Thr Gln Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala 
        995                 1000                 1005             


Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly 
    1010                 1015                 1020             


Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met 
    1025                 1030                 1035             


Ser Phe  Pro Gln Ser Ala Pro  His Gly Val Val Phe  Leu His Val 
    1040                 1045                 1050             


Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala 
    1055                 1060                 1065             


Ile Cys  His Asp Gly Lys Ala  His Phe Pro Arg Glu  Gly Val Phe 
    1070                 1075                 1080             


Val Ser  Asn Gly Thr His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr 
    1085                 1090                 1095             


Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn 
    1100                 1105                 1110             


Cys Asp  Val Val Ile Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro 
    1115                 1120                 1125             


Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr 
    1130                 1135                 1140             


Phe Lys  Asn His Thr Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser 
    1145                 1150                 1155             


Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg 
    1160                 1165                 1170             


Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu 
    1175                 1180                 1185             


Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr 
    1190                 1195                 1200             


Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile Ala Ile  Val Met Val 
    1205                 1210                 1215             


Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys 
    1220                 1225                 1230             


Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp 
    1235                 1240                 1245             


Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu His Tyr  Thr 
    1250                 1255                 1260     


<210>  3
<211>  3843
<212>  DNA
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, Spike with IgE leader

<400>  3
atggattgga cttggattct ctttctcgtt gctgcagcca cacgcgttca tagcagccag       60

tgtgtgaacc tgaccaccag aacacagctg cctcctgcct acaccaacag cttcaccaga      120

ggagtctact acccagacaa agtcttcaga agctctgtgc tgcacagcac ccaggacctg      180

ttcctgcctt tcttcagcaa cgtgacctgg ttccacgcca tccacgtgtc tggcaccaac      240

ggcaccaaga gatttgacaa ccctgttctt cctttcaatg atggcgtgta ctttgccagc      300

acagagaaga gcaacatcat ccgaggctgg atctttggca ccaccctgga cagcaaaacc      360

cagagcctgc tgatcgtgaa caacgccacc aacgtggtca tcaaggtgtg tgagttccag      420

ttctgcaatg accctttcct gggcgtgtac taccacaaga acaacaagtc ctggatggag      480

tctgagttca gagtctacag ctctgccaac aactgcacat ttgaatatgt gtcccagcct      540

ttcctgatgg acctggaggg caagcagggc aactttaaga acctgagaga atttgtgttc      600

aagaacatcg atggctactt caagatctac agcaagcaca cacccatcaa cctggtgaga      660

gacctgcctc agggcttctc tgccctggag cctctggtgg acctgcccat cggcatcaac      720

atcaccagat tccagaccct gctggccctg cacagaagct acctgacccc aggagacagc      780

agcagcggct ggacagctgg agctgctgcc tactacgtgg gctacctgca gcccaggacc      840

ttcctgctga agtacaacga aaatggcacc atcacagatg ctgttgactg tgccctggac      900

cctcttagcg agaccaagtg caccctgaag tccttcacag tggagaaagg catctaccag      960

accagcaact tccgagtgca gccaacagag agcatcgtga gatttccaaa catcaccaac     1020

ctgtgccctt ttggagaagt cttcaatgcc accagatttg cttctgtgta cgcctggaac     1080

agaaaaagaa tcagcaactg tgtggctgac tactctgtgc tgtacaactc tgcctccttc     1140

tccaccttca agtgctatgg agtctctcca accaagctga atgacctgtg cttcaccaac     1200

gtgtatgctg acagctttgt gatcagagga gatgaagtgc ggcagattgc tcctggccag     1260

acaggcaaga ttgctgacta caactacaag ctgcctgatg acttcacagg ctgtgtcatc     1320

gcctggaaca gcaacaacct ggacagcaag gtgggcggca actacaacta cctgtacaga     1380

cttttcagga agagcaacct gaagcctttt gaaagagaca tctccacaga gatctaccag     1440

gctggcagca caccctgcaa tggtgtggaa ggcttcaact gctacttccc tctgcagagc     1500

tacggcttcc agccaacaaa tggcgtgggc taccagcctt acagagtggt ggtgctgtcc     1560

tttgagctgc tgcacgcccc tgccacagtg tgtggcccca agaagagcac caacctggtg     1620

aagaacaaat gtgtgaactt caatttcaat ggcctgacag gcacaggagt gctgacagag     1680

agcaacaaga agtttcttcc tttccagcag tttggaagag acattgctga caccacagat     1740

gctgtgagag atcctcagac cctggagatc ctggatatca caccctgctc ctttggagga     1800

gtttctgtca tcacacctgg caccaatacc agcaaccaag tggctgtgct gtaccaagat     1860

gtgaattgca cagaagtgcc tgtggccatc cacgctgacc agctgacacc cacctggaga     1920

gtgtacagca caggcagcaa tgttttccag acaagagctg gctgcctgat tggagcagag     1980

cacgtgaaca acagctatga atgtgacatc cctattggag ctggcatctg tgccagctac     2040

cagacccaaa ccaacagccc aagaagagcc agatctgtgg ccagccagag catcatcgcc     2100

tacaccatga gcctgggagc tgagaactct gtggcctaca gcaacaacag catcgccatc     2160

cccaccaact tcaccatctc tgtgaccaca gagatcctgc ctgtgtccat gaccaagaca     2220

tctgtggact gcaccatgta catctgtgga gacagcacag aatgcagcaa cctgctgctg     2280

cagtacggct ccttctgcac ccagctgaac agagccctga caggcatcgc tgtggagcag     2340

gacaagaaca cacaggaagt gtttgcccag gtgaagcaga tctacaaaac accacccatc     2400

aaggactttg gaggcttcaa tttctcccaa atcctgcctg accccagcaa gccttccaag     2460

agaagcttca ttgaagacct gctgttcaac aaagtgaccc tggctgatgc tggcttcatc     2520

aagcagtatg gagactgcct gggagacatt gctgccagag acctgatctg tgcccagaag     2580

tttaatggcc tgactgtgct gcctcctctg ctgacagatg aaatgatcgc ccagtacaca     2640

tctgccctgc tggctggcac catcaccagt ggctggacat ttggagctgg agctgccctg     2700

cagatccctt ttgccatgca gatggcctac agatttaatg gcatcggcgt gacccagaac     2760

gtgctgtacg agaaccagaa gctgatcgcc aaccagttca actctgccat cggcaagatc     2820

caggacagcc tgagcagcac agcctctgcc ctgggcaagc tgcaggatgt ggtgaaccaa     2880

aacgcccagg ccctgaacac cctggtgaag cagctgagca gcaactttgg agccatctcc     2940

tctgtgctga atgacatcct gagccggctg gacaaggtgg aagcagaagt gcagatcgac     3000

agactcatca caggccgcct gcagagcctg cagacctacg tgacccagca gctgatcaga     3060

gctgctgaga tccgggcctc tgccaacctg gctgccacca agatgtcaga atgtgtgctg     3120

ggccagagca aaagagtgga cttctgtggc aaaggctacc acctgatgtc cttccctcag     3180

tctgctcctc acggcgtggt gttcctgcac gtgacctacg tgcctgccca ggagaagaac     3240

ttcaccacag ctcctgccat ctgccacgat ggcaaggccc acttcccaag agaaggtgtc     3300

tttgtgtcca atggcaccca ctggttcgtg acccagagaa acttctacga gcctcagatc     3360

atcaccacag acaacacatt tgtgtctggc aactgtgatg tggtcatcgg catcgtgaac     3420

aacacagttt atgaccctct gcagcctgag ctggacagct tcaaagaaga gctggacaag     3480

tacttcaaga accacacatc tccagatgtg gacctgggag acatctctgg catcaatgcc     3540

tctgtggtga acatccagaa ggaaattgac aggctgaacg aagtggccaa gaacctgaac     3600

gaaagcctca tcgacctgca ggagctgggc aagtacgagc agtacatcaa gtggccttgg     3660

tacatctggc tgggcttcat cgctggcctc atcgccatcg tgatggtgac catcatgctg     3720

tgctgcatga ccagctgctg ctcttgcctg aagggctgct gcagctgtgg cagctgctgc     3780

aagtttgatg aagatgactc tgagcctgtg ctgaagggcg tgaagctgca ctacacataa     3840

tga                                                                   3843


<210>  4
<211>  1279
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, Spike with IgE leader

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
                245                 250                 255     


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
            260                 265                 270         


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
        275                 280                 285             


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
    290                 295                 300                 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
305                 310                 315                 320 


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
                325                 330                 335     


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
            340                 345                 350         


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
        355                 360                 365             


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
    370                 375                 380                 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
385                 390                 395                 400 


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
                405                 410                 415     


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
            420                 425                 430         


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
        435                 440                 445             


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
    450                 455                 460                 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
465                 470                 475                 480 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
                485                 490                 495     


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
            500                 505                 510         


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
        515                 520                 525             


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
    530                 535                 540                 


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala 
                565                 570                 575     


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
            580                 585                 590         


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
        595                 600                 605             


Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
    610                 615                 620                 


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
625                 630                 635                 640 


Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu 
                645                 650                 655     


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
            660                 665                 670         


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg 
        675                 680                 685             


Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser 
    690                 695                 700                 


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
705                 710                 715                 720 


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
                725                 730                 735     


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
            740                 745                 750         


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
        755                 760                 765             


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
    770                 775                 780                 


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
785                 790                 795                 800 


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
                805                 810                 815     


Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
            820                 825                 830         


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
        835                 840                 845             


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
    850                 855                 860                 


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
865                 870                 875                 880 


Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala 
                885                 890                 895     


Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe 
            900                 905                 910         


Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
        915                 920                 925             


Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
    930                 935                 940                 


Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
945                 950                 955                 960 


Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe 
                965                 970                 975     


Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys 
            980                 985                 990         


Val Glu Ala Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
        995                 1000                 1005             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1010                 1015                 1020             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1025                 1030                 1035             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1040                 1045                 1050             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1055                 1060                 1065             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1070                 1075                 1080             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1085                 1090                 1095             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1100                 1105                 1110             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1115                 1120                 1125             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1130                 1135                 1140             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1145                 1150                 1155             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1160                 1165                 1170             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1175                 1180                 1185             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1190                 1195                 1200             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1205                 1210                 1215             


Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile 
    1220                 1225                 1230             


Val Met  Val Thr Ile Met Leu  Cys Cys Met Thr Ser  Cys Cys Ser 
    1235                 1240                 1245             


Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp 
    1250                 1255                 1260             


Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly Val Lys  Leu His Tyr 
    1265                 1270                 1275             


Thr 
    


<210>  5
<211>  3783
<212>  DNA
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, Spike OL

<400>  5
agccagtgtg tgaacctgac caccagaaca cagctgcctc ctgcctacac caacagcttc       60

accagaggag tctactaccc agacaaggtg ttcagaagct ctgtgctgca cagcacccag      120

gacctcttcc tgcctttctt cagcaacgtg acctggttcc acgccatcca cgtgtctggc      180

accaacggca ccaagagatt tgacaaccct gtgctgcctt tcaatgatgg tgtgtacttt      240

gccagcacag agaagagcaa catcatccga ggctggatct ttggcaccac cctggacagc      300

aaaacacaga gcctgctgat cgtgaataat gccaccaacg tggtcatcaa ggtgtgtgag      360

ttccagttct gcaatgaccc tttcctgggc gtgtactacc acaagaacaa caagtcctgg      420

atggagtctg agttccgagt gtacagctct gccaacaact gcacatttga atatgtgtcc      480

cagcctttcc tgatggacct ggagggcaag cagggcaatt tcaagaacct gagagaattt      540

gtgttcaaga acatcgatgg ctacttcaag atctacagca agcacacacc catcaacctg      600

gtgagagatc ttcctcaggg cttctctgcc ctggagcctc tggtggacct gcccatcggc      660

atcaacatca cccgctttca gaccctgctg gccctgcaca gaagctacct gaccccagga      720

gacagcagca gcggctggac agctggagct gctgcctact acgtgggcta cctgcagcca      780

agaaccttcc tgctgaagta caacgaaaat ggcaccatca ctgtggctgt ggcctgtgcc      840

ctggaccctc tttctgagac caagtgcacc ctgaagtcct tcacagtgga gaaaggcatc      900

taccagacca gcaacttcag agttcagcca acagagagca tcgtgagatt tccaaacatc      960

accaacctgt gtccttttgg agaagtcttc aatgccacca gatttgcttc tgtgtacgcc     1020

tggaacagaa aaagaatcag caactgtgtg gctgactact ctgtgctgta caactctgcc     1080

tccttctcca ccttcaagtg ctacggtgtg tctcctacca agctgaatga cctgtgcttc     1140

accaacgtgt atgctgacag ctttgtcatc agaggagatg aagtgcggca gatcgcccct     1200

ggccagacag gcaagattgc tgactacaac tacaagctgc ctgatgactt cacaggctgt     1260

gtcatcgcct ggaacagcaa caacctggac agcaaggtgg gcggcaacta caactacctg     1320

tacagacttt tcaggaagag caacctgaag ccttttgaaa gagacatctc cacagagatc     1380

taccaggctg gcagcacacc ctgcaatgga gtggaaggct tcaactgcta cttccctctg     1440

cagagctacg gcttccagcc caccaatggc gtgggctacc agccttacag agtggtggtg     1500

ctgtcctttg agctgctgca cgcccctgcc acagtgtgtg gccccaagaa gagcaccaac     1560

ctggtgaaga acaaatgtgt gaacttcaat ttcaatggcc tgacaggcac aggagtgctg     1620

acagagagca acaagaagtt cctgcctttc cagcagtttg gaagagacat tgctgacacc     1680

acagatgctg tgagagatcc tcagaccctg gagatcctgg acatcacacc ctgctccttt     1740

ggaggagttt ctgtcatcac acctggagcc aacaccagca accaagtgac agtgctgtac     1800

caagatgtga actgcacaga agttcctgtg gccatccacg ctgaccagct gaccccaacc     1860

tggagagtct acagcacagg cagcaacgtg tttaaaacaa gagctggctg cctgattgga     1920

gcagagcacg tgaacaacag ctatgaatgt gacatcccta ttggagctgg catctgtgcc     1980

agctaccaga cccaaaccaa cagcccaaga agagccagga gcacagccag ccagagcatc     2040

atcgcctaca ccatgagcct gggagcagag aactctgtgg cctacagcaa caacagcatc     2100

gtcatcccca ccaacttcac catctctgtg accacagaga tcctgcctgt gtccatgacc     2160

aagacatctg tggactgcac catgtacatc tgcagtgaca gcacagaatg cagcaaccct     2220

ctgctgcagt acggctcctt ctgcacccag ctgaacagag ccctgacagg catcgctgtg     2280

gagcaggaca agaacacaca ggaagtgttt gcccaggtga agcagatcta caaaacacca     2340

cccatcaagg actttggagg cttcaacttc tcccagatcc tgcctgaccc cagcaagccc     2400

agcaagagaa gcttcattga agacctgctg ttcaacaaag tgaccctggc tgatgctggc     2460

ttcatcaaac aatatggaga ctgcctggga gacattgctg ccagagacct gatctgtgcc     2520

cagaagttta atggcctgac tgtgctgcct cctctgctga cagatgaaat gatcgcccag     2580

tacacatctg ccctgctggc tggcaccatc acatctggct ggacatttgg agctggagct     2640

gccctgcaga tcccttttgc catgcagatg gcctacagat ttaatggcat cagagtgacc     2700

cagaacgtgc tgtatgaaaa ccagaagctg atcgccaacc agttcaactc tgccatcggc     2760

aagatccagg acagcctgag cagcacagcc tctgccctgg gcaagctgca ggatgtggtg     2820

aaccaaaatg cccaggccct gaacaccctg gtgaagcagc tgagcagcac cttctccacc     2880

atctccagcg tgctgaatga catcctgagc cggctggaca aggtggaagc tgaggtgcag     2940

atcgacagac tcatcacagg ccggctgcag agcctgcaga cctacgtgac ccagcagctg     3000

atcagagctg ctgagatcag agcttctgcc aacctgaagg ccaccaagat gtcagaatgt     3060

gtgctgggcc agagcaagag agtggacttc tgtggcaaag gctaccacct gatgtccttc     3120

cctcagtctg ctcctcacgg cgtggtgttc ctgcacgtga cctacgtgcc tgcccaggag     3180

aagaacttca ccacagctcc tgccacctgc cacgatggca aagcccactt cccaagagaa     3240

ggcgtctttg tgtccaatgg cacccactgg ttcgtgaccc agagaaactt tgatgagcct     3300

cagatcatca ccacagacaa cacatttgtt tctggcaact gtgatgtggt catcggcatc     3360

gtgaacaaca cagtttatga ccctctgcag cctgagctgg acagcttcaa agaagagctg     3420

gacaagtact tcaagaacca cacatctcca gatgtggacc tgggagacat ctctggcatc     3480

aatgcctctg tggtgaacat ccagaaggaa attgacaggc tgaacgaagt ggccaagaac     3540

ctgaacgaaa gcctcatcga cctgcaggag ctgggcaagt acgagcagta catcaagtgg     3600

ccttggtaca tctggctggg cttcattgct ggcctcatcg ccatcgtgat ggtgaccatc     3660

atgctgtgct gcatgaccag ctgctgctct tgcctgaagg gctgctgcag ctgtggcagc     3720

tgctgcaagt ttgatgaaga tgactctgag cctgtgctga agggcgtgaa gctgcactac     3780

aca                                                                   3783


<210>  6
<211>  1261
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, Spike OL

<400>  6

Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
1               5                   10                  15      


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
            20                  25                  30          


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
        35                  40                  45              


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
    50                  55                  60                  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
65                  70                  75                  80  


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
                85                  90                  95      


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
            100                 105                 110         


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
        115                 120                 125             


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
    130                 135                 140                 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
145                 150                 155                 160 


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
                165                 170                 175     


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
            180                 185                 190         


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
        195                 200                 205             


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
    210                 215                 220                 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
225                 230                 235                 240 


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
                245                 250                 255     


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
            260                 265                 270         


Ile Thr Val Ala Val Ala Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
        275                 280                 285             


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
    290                 295                 300                 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
305                 310                 315                 320 


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
                325                 330                 335     


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
            340                 345                 350         


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        355                 360                 365             


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    370                 375                 380                 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                405                 410                 415     


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            420                 425                 430         


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
        435                 440                 445             


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
    450                 455                 460                 


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
465                 470                 475                 480 


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
                485                 490                 495     


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
            500                 505                 510         


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
        515                 520                 525             


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
    530                 535                 540                 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
545                 550                 555                 560 


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
                565                 570                 575     


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Ala Asn Thr 
            580                 585                 590         


Ser Asn Gln Val Thr Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
        595                 600                 605             


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
    610                 615                 620                 


Ser Thr Gly Ser Asn Val Phe Lys Thr Arg Ala Gly Cys Leu Ile Gly 
625                 630                 635                 640 


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
                645                 650                 655     


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala 
            660                 665                 670         


Arg Ser Thr Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
        675                 680                 685             


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Val Ile Pro Thr 
    690                 695                 700                 


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
705                 710                 715                 720 


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Ser Asp Ser Thr Glu 
                725                 730                 735     


Cys Ser Asn Pro Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
            740                 745                 750         


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
        755                 760                 765             


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
    770                 775                 780                 


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
785                 790                 795                 800 


Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
                805                 810                 815     


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
            820                 825                 830         


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
        835                 840                 845             


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
    850                 855                 860                 


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
865                 870                 875                 880 


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
                885                 890                 895     


Ile Arg Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
            900                 905                 910         


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
        915                 920                 925             


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
    930                 935                 940                 


Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Thr Phe Ser Thr 
945                 950                 955                 960 


Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu 
                965                 970                 975     


Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu 
            980                 985                 990         


Gln Thr Tyr Val Thr Gln Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala 
        995                 1000                 1005             


Ser Ala  Asn Leu Lys Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly 
    1010                 1015                 1020             


Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met 
    1025                 1030                 1035             


Ser Phe  Pro Gln Ser Ala Pro  His Gly Val Val Phe  Leu His Val 
    1040                 1045                 1050             


Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala 
    1055                 1060                 1065             


Thr Cys  His Asp Gly Lys Ala  His Phe Pro Arg Glu  Gly Val Phe 
    1070                 1075                 1080             


Val Ser  Asn Gly Thr His Trp  Phe Val Thr Gln Arg  Asn Phe Asp 
    1085                 1090                 1095             


Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn 
    1100                 1105                 1110             


Cys Asp  Val Val Ile Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro 
    1115                 1120                 1125             


Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr 
    1130                 1135                 1140             


Phe Lys  Asn His Thr Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser 
    1145                 1150                 1155             


Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg 
    1160                 1165                 1170             


Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu 
    1175                 1180                 1185             


Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr 
    1190                 1195                 1200             


Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile Ala Ile  Val Met Val 
    1205                 1210                 1215             


Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys 
    1220                 1225                 1230             


Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp 
    1235                 1240                 1245             


Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu His Tyr  Thr 
    1250                 1255                 1260     


<210>  7
<211>  3843
<212>  DNA
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, Spike OL with IgE leader

<400>  7
atggattgga cctggattct ttttctcgtt gcagctgcta cacgcgttca tagcagccag       60

tgtgtgaacc tgaccaccag aacacagctg cctcctgcct acaccaacag cttcaccaga      120

ggagtctact acccagacaa ggtgttcaga agctctgtgc tgcacagcac ccaggacctc      180

ttcctgcctt tcttcagcaa cgtgacctgg ttccacgcca tccacgtgtc tggcaccaac      240

ggcaccaaga gatttgacaa ccctgtgctg cctttcaatg atggtgtgta ctttgccagc      300

acagagaaga gcaacatcat ccgaggctgg atctttggca ccaccctgga cagcaaaaca      360

cagagcctgc tgatcgtgaa taatgccacc aacgtggtca tcaaggtgtg tgagttccag      420

ttctgcaatg accctttcct gggcgtgtac taccacaaga acaacaagtc ctggatggag      480

tctgagttcc gagtgtacag ctctgccaac aactgcacat ttgaatatgt gtcccagcct      540

ttcctgatgg acctggaggg caagcagggc aatttcaaga acctgagaga atttgtgttc      600

aagaacatcg atggctactt caagatctac agcaagcaca cacccatcaa cctggtgaga      660

gatcttcctc agggcttctc tgccctggag cctctggtgg acctgcccat cggcatcaac      720

atcacccgct ttcagaccct gctggccctg cacagaagct acctgacccc aggagacagc      780

agcagcggct ggacagctgg agctgctgcc tactacgtgg gctacctgca gccaagaacc      840

ttcctgctga agtacaacga aaatggcacc atcactgtgg ctgtggcctg tgccctggac      900

cctctttctg agaccaagtg caccctgaag tccttcacag tggagaaagg catctaccag      960

accagcaact tcagagttca gccaacagag agcatcgtga gatttccaaa catcaccaac     1020

ctgtgtcctt ttggagaagt cttcaatgcc accagatttg cttctgtgta cgcctggaac     1080

agaaaaagaa tcagcaactg tgtggctgac tactctgtgc tgtacaactc tgcctccttc     1140

tccaccttca agtgctacgg tgtgtctcct accaagctga atgacctgtg cttcaccaac     1200

gtgtatgctg acagctttgt catcagagga gatgaagtgc ggcagatcgc ccctggccag     1260

acaggcaaga ttgctgacta caactacaag ctgcctgatg acttcacagg ctgtgtcatc     1320

gcctggaaca gcaacaacct ggacagcaag gtgggcggca actacaacta cctgtacaga     1380

cttttcagga agagcaacct gaagcctttt gaaagagaca tctccacaga gatctaccag     1440

gctggcagca caccctgcaa tggagtggaa ggcttcaact gctacttccc tctgcagagc     1500

tacggcttcc agcccaccaa tggcgtgggc taccagcctt acagagtggt ggtgctgtcc     1560

tttgagctgc tgcacgcccc tgccacagtg tgtggcccca agaagagcac caacctggtg     1620

aagaacaaat gtgtgaactt caatttcaat ggcctgacag gcacaggagt gctgacagag     1680

agcaacaaga agttcctgcc tttccagcag tttggaagag acattgctga caccacagat     1740

gctgtgagag atcctcagac cctggagatc ctggacatca caccctgctc ctttggagga     1800

gtttctgtca tcacacctgg agccaacacc agcaaccaag tgacagtgct gtaccaagat     1860

gtgaactgca cagaagttcc tgtggccatc cacgctgacc agctgacccc aacctggaga     1920

gtctacagca caggcagcaa cgtgtttaaa acaagagctg gctgcctgat tggagcagag     1980

cacgtgaaca acagctatga atgtgacatc cctattggag ctggcatctg tgccagctac     2040

cagacccaaa ccaacagccc aagaagagcc aggagcacag ccagccagag catcatcgcc     2100

tacaccatga gcctgggagc agagaactct gtggcctaca gcaacaacag catcgtcatc     2160

cccaccaact tcaccatctc tgtgaccaca gagatcctgc ctgtgtccat gaccaagaca     2220

tctgtggact gcaccatgta catctgcagt gacagcacag aatgcagcaa ccctctgctg     2280

cagtacggct ccttctgcac ccagctgaac agagccctga caggcatcgc tgtggagcag     2340

gacaagaaca cacaggaagt gtttgcccag gtgaagcaga tctacaaaac accacccatc     2400

aaggactttg gaggcttcaa cttctcccag atcctgcctg accccagcaa gcccagcaag     2460

agaagcttca ttgaagacct gctgttcaac aaagtgaccc tggctgatgc tggcttcatc     2520

aaacaatatg gagactgcct gggagacatt gctgccagag acctgatctg tgcccagaag     2580

tttaatggcc tgactgtgct gcctcctctg ctgacagatg aaatgatcgc ccagtacaca     2640

tctgccctgc tggctggcac catcacatct ggctggacat ttggagctgg agctgccctg     2700

cagatccctt ttgccatgca gatggcctac agatttaatg gcatcagagt gacccagaac     2760

gtgctgtatg aaaaccagaa gctgatcgcc aaccagttca actctgccat cggcaagatc     2820

caggacagcc tgagcagcac agcctctgcc ctgggcaagc tgcaggatgt ggtgaaccaa     2880

aatgcccagg ccctgaacac cctggtgaag cagctgagca gcaccttctc caccatctcc     2940

agcgtgctga atgacatcct gagccggctg gacaaggtgg aagctgaggt gcagatcgac     3000

agactcatca caggccggct gcagagcctg cagacctacg tgacccagca gctgatcaga     3060

gctgctgaga tcagagcttc tgccaacctg aaggccacca agatgtcaga atgtgtgctg     3120

ggccagagca agagagtgga cttctgtggc aaaggctacc acctgatgtc cttccctcag     3180

tctgctcctc acggcgtggt gttcctgcac gtgacctacg tgcctgccca ggagaagaac     3240

ttcaccacag ctcctgccac ctgccacgat ggcaaagccc acttcccaag agaaggcgtc     3300

tttgtgtcca atggcaccca ctggttcgtg acccagagaa actttgatga gcctcagatc     3360

atcaccacag acaacacatt tgtttctggc aactgtgatg tggtcatcgg catcgtgaac     3420

aacacagttt atgaccctct gcagcctgag ctggacagct tcaaagaaga gctggacaag     3480

tacttcaaga accacacatc tccagatgtg gacctgggag acatctctgg catcaatgcc     3540

tctgtggtga acatccagaa ggaaattgac aggctgaacg aagtggccaa gaacctgaac     3600

gaaagcctca tcgacctgca ggagctgggc aagtacgagc agtacatcaa gtggccttgg     3660

tacatctggc tgggcttcat tgctggcctc atcgccatcg tgatggtgac catcatgctg     3720

tgctgcatga ccagctgctg ctcttgcctg aagggctgct gcagctgtgg cagctgctgc     3780

aagtttgatg aagatgactc tgagcctgtg ctgaagggcg tgaagctgca ctacacataa     3840

tga                                                                   3843


<210>  8
<211>  1279
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, Spike OL with IgE leader

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
                245                 250                 255     


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
            260                 265                 270         


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
        275                 280                 285             


Gly Thr Ile Thr Val Ala Val Ala Cys Ala Leu Asp Pro Leu Ser Glu 
    290                 295                 300                 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
305                 310                 315                 320 


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
                325                 330                 335     


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
            340                 345                 350         


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
        355                 360                 365             


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
    370                 375                 380                 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
385                 390                 395                 400 


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
                405                 410                 415     


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
            420                 425                 430         


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
        435                 440                 445             


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
    450                 455                 460                 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
465                 470                 475                 480 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
                485                 490                 495     


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
            500                 505                 510         


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
        515                 520                 525             


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
    530                 535                 540                 


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala 
                565                 570                 575     


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
            580                 585                 590         


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Ala 
        595                 600                 605             


Asn Thr Ser Asn Gln Val Thr Val Leu Tyr Gln Asp Val Asn Cys Thr 
    610                 615                 620                 


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
625                 630                 635                 640 


Val Tyr Ser Thr Gly Ser Asn Val Phe Lys Thr Arg Ala Gly Cys Leu 
                645                 650                 655     


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
            660                 665                 670         


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg 
        675                 680                 685             


Arg Ala Arg Ser Thr Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser 
    690                 695                 700                 


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Val Ile 
705                 710                 715                 720 


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
                725                 730                 735     


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Ser Asp Ser 
            740                 745                 750         


Thr Glu Cys Ser Asn Pro Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
        755                 760                 765             


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
    770                 775                 780                 


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
785                 790                 795                 800 


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
                805                 810                 815     


Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
            820                 825                 830         


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
        835                 840                 845             


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
    850                 855                 860                 


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
865                 870                 875                 880 


Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala 
                885                 890                 895     


Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe 
            900                 905                 910         


Asn Gly Ile Arg Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
        915                 920                 925             


Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
    930                 935                 940                 


Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
945                 950                 955                 960 


Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Thr Phe 
                965                 970                 975     


Ser Thr Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys 
            980                 985                 990         


Val Glu Ala Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
        995                 1000                 1005             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1010                 1015                 1020             


Ile Arg  Ala Ser Ala Asn Leu  Lys Ala Thr Lys Met  Ser Glu Cys 
    1025                 1030                 1035             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1040                 1045                 1050             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1055                 1060                 1065             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1070                 1075                 1080             


Ala Pro  Ala Thr Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1085                 1090                 1095             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1100                 1105                 1110             


Asn Phe  Asp Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1115                 1120                 1125             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1130                 1135                 1140             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1145                 1150                 1155             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1160                 1165                 1170             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1175                 1180                 1185             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1190                 1195                 1200             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1205                 1210                 1215             


Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile 
    1220                 1225                 1230             


Val Met  Val Thr Ile Met Leu  Cys Cys Met Thr Ser  Cys Cys Ser 
    1235                 1240                 1245             


Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp 
    1250                 1255                 1260             


Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly Val Lys  Leu His Tyr 
    1265                 1270                 1275             


Thr 
    


<210>  9
<211>  18
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, IgE leader

<400>  9

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, H2-Kd epitope

<400>  10

Pro His Gly Val Val Phe Leu His Val 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, peptide 71663

<400>  11

Val Val Phe Leu His Val Thr Tyr Val 
1               5                   


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, peptide 86

<400>  12

Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, peptide 90

<400>  13

Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, peptide 87

<400>  14

Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, peptide 176

<400>  15

Ser Phe Pro Gln Ser Ala Pro His Gly Val Val Phe Leu His Val 
1               5                   10                  15  


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, peptide 180

<400>  16

Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His Phe 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, peptide 177

<400>  17

Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln 
1               5                   10                  15  


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, peptide 71

<400>  18

Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, peptide 75

<400>  19

Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequnce

<220>
<223>  Chemically Synthesized, peptide 72

<400>  20

Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
1               5                   10                  15  


