                               SEQUENCE LISTING

<110> INOZYME PHARMA, INC.
 
<120> SOLUBLE ENPP1 PROTEINS AND USES THEREOF

<130> 1886569-001-WO1

<140> PCT/US2021/036494
<141> 2021-06-08

<150> 63/036,833
<151> 2020-06-09

<160> 134   

<170> PatentIn version 3.5

<210> 1
<211> 925
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu 
65                  70                  75                  80  


Val Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
        915                 920                 925 


<210> 2
<211> 827
<212> PRT
<213> Homo sapiens

<400> 2
Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
            820                 825         


<210> 3
<211> 736
<212> PRT
<213> Homo sapiens

<400> 3
Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala 
1               5                   10                  15      


Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg 
            20                  25                  30          


Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys 
        35                  40                  45              


Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro 
    50                  55                  60                  


Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro 
65                  70                  75                  80  


Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn 
                85                  90                  95      


Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr 
            100                 105                 110         


Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser 
        115                 120                 125             


Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe 
    130                 135                 140                 


Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg 
145                 150                 155                 160 


Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro 
                165                 170                 175     


His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser 
            180                 185                 190         


Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp 
        195                 200                 205             


Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His 
    210                 215                 220                 


Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly 
225                 230                 235                 240 


Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys 
                245                 250                 255     


Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp 
            260                 265                 270         


Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn 
        275                 280                 285             


Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His 
    290                 295                 300                 


Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro 
305                 310                 315                 320 


Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser 
                325                 330                 335     


Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe 
            340                 345                 350         


Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His 
        355                 360                 365             


Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met 
    370                 375                 380                 


Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly 
385                 390                 395                 400 


Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro 
                405                 410                 415     


Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg 
            420                 425                 430         


Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp 
        435                 440                 445             


Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys 
    450                 455                 460                 


His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn 
465                 470                 475                 480 


Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln 
                485                 490                 495     


Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp 
            500                 505                 510         


Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg 
        515                 520                 525             


Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr 
    530                 535                 540                 


Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser 
545                 550                 555                 560 


Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met 
                565                 570                 575     


Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu 
            580                 585                 590         


Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro 
        595                 600                 605             


Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu 
    610                 615                 620                 


Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr 
625                 630                 635                 640 


His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro 
                645                 650                 655     


Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg 
            660                 665                 670         


Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp 
        675                 680                 685             


Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu 
    690                 695                 700                 


His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser 
705                 710                 715                 720 


Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
                725                 730                 735     


<210> 4
<211> 735
<212> PRT
<213> Mus musculus

<400> 4
Trp Val Glu Glu Thr Cys Glu Ser Ile Asp Thr Pro Glu Cys Pro Ala 
1               5                   10                  15      


Glu Phe Glu Ser Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg 
            20                  25                  30          


Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys 
        35                  40                  45              


Leu Lys Asn Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Met Tyr Pro 
    50                  55                  60                  


Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro 
65                  70                  75                  80  


Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn 
                85                  90                  95      


Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Leu Trp Tyr 
            100                 105                 110         


Lys Gly Gln Pro Ile Trp Val Thr Ala Asn His Gln Glu Val Lys Ser 
        115                 120                 125             


Gly Thr Tyr Phe Trp Pro Gly Ser Asp Val Glu Ile Asp Gly Ile Leu 
    130                 135                 140                 


Pro Asp Ile Tyr Lys Val Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg 
145                 150                 155                 160 


Ile Leu Ala Val Leu Glu Trp Leu Gln Leu Pro Ser His Glu Arg Pro 
                165                 170                 175     


His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser 
            180                 185                 190         


His Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Lys Val Asp 
        195                 200                 205             


Arg Leu Val Gly Met Leu Met Asp Gly Leu Lys Asp Leu Gly Leu Asp 
    210                 215                 220                 


Lys Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly 
225                 230                 235                 240 


Ser Cys Lys Lys Tyr Val Tyr Leu Asn Lys Tyr Leu Gly Asp Val Asn 
                245                 250                 255     


Asn Val Lys Val Val Tyr Gly Pro Ala Ala Arg Leu Arg Pro Thr Asp 
            260                 265                 270         


Val Pro Glu Thr Tyr Tyr Ser Phe Asn Tyr Glu Ala Leu Ala Lys Asn 
        275                 280                 285             


Leu Ser Cys Arg Glu Pro Asn Gln His Phe Arg Pro Tyr Leu Lys Pro 
    290                 295                 300                 


Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro 
305                 310                 315                 320 


Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser 
                325                 330                 335     


Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Leu Phe 
            340                 345                 350         


Ser Asn Met Gln Ala Leu Phe Ile Gly Tyr Gly Pro Ala Phe Lys His 
        355                 360                 365             


Gly Ala Glu Val Asp Ser Phe Glu Asn Ile Glu Val Tyr Asn Leu Met 
    370                 375                 380                 


Cys Asp Leu Leu Gly Leu Ile Pro Ala Pro Asn Asn Gly Ser His Gly 
385                 390                 395                 400 


Ser Leu Asn His Leu Leu Lys Lys Pro Ile Tyr Asn Pro Ser His Pro 
                405                 410                 415     


Lys Glu Glu Gly Phe Leu Ser Gln Cys Pro Ile Lys Ser Thr Ser Asn 
            420                 425                 430         


Asp Leu Gly Cys Thr Cys Asp Pro Trp Ile Val Pro Ile Lys Asp Phe 
        435                 440                 445             


Glu Lys Gln Leu Asn Leu Thr Thr Glu Asp Val Asp Asp Ile Tyr His 
    450                 455                 460                 


Met Thr Val Pro Tyr Gly Arg Pro Arg Ile Leu Leu Lys Gln His Arg 
465                 470                 475                 480 


Val Cys Leu Leu Gln Gln Gln Gln Phe Leu Thr Gly Tyr Ser Leu Asp 
                485                 490                 495     


Leu Leu Met Pro Leu Trp Ala Ser Tyr Thr Phe Leu Ser Asn Asp Gln 
            500                 505                 510         


Phe Ser Arg Asp Asp Phe Ser Asn Cys Leu Tyr Gln Asp Leu Arg Ile 
        515                 520                 525             


Pro Leu Ser Pro Val His Lys Cys Ser Tyr Tyr Lys Ser Asn Ser Lys 
    530                 535                 540                 


Leu Ser Tyr Gly Phe Leu Thr Pro Pro Arg Leu Asn Arg Val Ser Asn 
545                 550                 555                 560 


His Ile Tyr Ser Glu Ala Leu Leu Thr Ser Asn Ile Val Pro Met Tyr 
                565                 570                 575     


Gln Ser Phe Gln Val Ile Trp His Tyr Leu His Asp Thr Leu Leu Gln 
            580                 585                 590         


Arg Tyr Ala His Glu Arg Asn Gly Ile Asn Val Val Ser Gly Pro Val 
        595                 600                 605             


Phe Asp Phe Asp Tyr Asp Gly Arg Tyr Asp Ser Leu Glu Ile Leu Lys 
    610                 615                 620                 


Gln Asn Ser Arg Val Ile Arg Ser Gln Glu Ile Leu Ile Pro Thr His 
625                 630                 635                 640 


Phe Phe Ile Val Leu Thr Ser Cys Lys Gln Leu Ser Glu Thr Pro Leu 
                645                 650                 655     


Glu Cys Ser Ala Leu Glu Ser Ser Ala Tyr Ile Leu Pro His Arg Pro 
            660                 665                 670         


Asp Asn Ile Glu Ser Cys Thr His Gly Lys Arg Glu Ser Ser Trp Val 
        675                 680                 685             


Glu Glu Leu Leu Thr Leu His Arg Ala Arg Val Thr Asp Val Glu Leu 
    690                 695                 700                 


Ile Thr Gly Leu Ser Phe Tyr Gln Asp Arg Gln Glu Ser Val Ser Glu 
705                 710                 715                 720 


Leu Leu Arg Leu Lys Thr His Leu Pro Ile Phe Ser Gln Glu Asp 
                725                 730                 735 


<210> 5
<211> 735
<212> PRT
<213> Bos taurus

<400> 5
Trp Ala Glu Glu Glu Cys Asp Ser Ile Asp Glu Pro Gln Cys Pro Ala 
1               5                   10                  15      


Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg 
            20                  25                  30          


Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys 
        35                  40                  45              


Leu Lys Thr Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro 
    50                  55                  60                  


Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro 
65                  70                  75                  80  


Glu Ser His Gly Ile Ile Asp Asn Asn Ile Tyr Asp Pro Gln Met Asn 
                85                  90                  95      


Ala Asn Phe Ala Leu Lys Asn Lys Glu Lys Phe Asn Pro Glu Trp Tyr 
            100                 105                 110         


Lys Gly Glu Pro Ile Trp Leu Thr Ala Lys Tyr Gln Gly Leu Lys Thr 
        115                 120                 125             


Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Lys Ile Asn Gly Ile Phe 
    130                 135                 140                 


Pro Asp Ile Tyr Lys Ile Tyr Asn Val Ser Val Pro Phe Glu Glu Arg 
145                 150                 155                 160 


Ile Leu Ala Ile Leu Lys Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro 
                165                 170                 175     


His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser 
            180                 185                 190         


Tyr Gly Pro Val Ser Ser Glu Val Ile Arg Ala Leu Gln Arg Val Asp 
        195                 200                 205             


Asn Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His 
    210                 215                 220                 


Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly 
225                 230                 235                 240 


Ser Cys Lys Lys Tyr Val Tyr Leu Asn Lys Tyr Leu Gly Asp Thr Lys 
                245                 250                 255     


Asp Tyr Lys Val Val Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp 
            260                 265                 270         


Val Pro Asp Lys Tyr Tyr Ser Phe Asp Tyr Glu Gly Ile Ala Lys Asn 
        275                 280                 285             


Leu Ser Cys Gln Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His 
    290                 295                 300                 


Phe Leu Pro Lys Arg Leu His Phe Ala Lys Asn Asp Arg Ile Glu Arg 
305                 310                 315                 320 


Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser 
                325                 330                 335     


Glu Arg Lys Tyr Cys Gly Gly Gly Phe His Gly Ser Asp Asn Thr Phe 
            340                 345                 350         


Leu Asn Met Gln Ala Leu Phe Ile Gly Tyr Gly Pro Gly Phe Lys His 
        355                 360                 365             


Ser Thr Glu Val Asp Ser Phe Glu Asn Ile Glu Val Tyr Asn Leu Met 
    370                 375                 380                 


Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly 
385                 390                 395                 400 


Ser Leu Asn His Leu Leu Ser Asn Pro Val Tyr Thr Pro Lys His Pro 
                405                 410                 415     


Lys Glu Val Arg Pro Leu Val Gln Cys Pro Phe Thr Arg Ala Pro Arg 
            420                 425                 430         


Glu Ser Leu Asp Cys Ser Cys Asp Pro Ser Ile Leu Pro Ile Val Asp 
        435                 440                 445             


Phe Gln Thr Gln Leu Asn Leu Thr Met Ala Glu Glu Lys Thr Ile Lys 
    450                 455                 460                 


Arg Gly Ala Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Asn Ser Thr 
465                 470                 475                 480 


Val Cys Leu Leu Tyr Gln His Gln Phe Val Ser Gly Tyr Ser Arg Asp 
                485                 490                 495     


Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Ile Gly Arg Asn Asp Ser 
            500                 505                 510         


Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Leu Arg Ile 
        515                 520                 525             


Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Ala Lys 
    530                 535                 540                 


Leu Ser Tyr Gly Leu Leu Ser Pro Pro Gln Leu His Lys Gly Ser Ser 
545                 550                 555                 560 


Gln Val Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr 
                565                 570                 575     


Gln Ser Phe Gln Val Ile Trp His Tyr Leu His Gly Thr Leu Leu Gln 
            580                 585                 590         


Arg Tyr Ala Glu Glu Arg Asn Gly Leu Asn Val Val Ser Gly Pro Val 
        595                 600                 605             


Phe Asp Ser Asp Tyr Asp Gly Arg Tyr Asp Ser Leu Glu Thr Leu Lys 
    610                 615                 620                 


Gln Asn Ser Lys Ile Ile Arg Asn Leu Glu Val Leu Ile Pro Thr His 
625                 630                 635                 640 


Phe Phe Leu Val Leu Thr Ser Cys Lys Asn Thr Ser Gln Thr Pro Leu 
                645                 650                 655     


Gln Cys Glu Asn Leu Asp Ala Met Ala Phe Ile Leu Pro His Lys Thr 
            660                 665                 670         


Asp Asn Ser Glu Ser Cys Ala His Gly Lys His Glu Ser Leu Trp Val 
        675                 680                 685             


Glu Glu Leu Leu Lys Leu His Thr Ala Arg Ile Thr Asp Val Glu His 
    690                 695                 700                 


Ile Thr Gly Leu Ser Phe Tyr Gln Glu Arg Lys Glu Pro Ile Ser Asp 
705                 710                 715                 720 


Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Asn Gln Glu Asp 
                725                 730                 735 


<210> 6
<211> 736
<212> PRT
<213> Oryctolagus cuniculus

<400> 6
Trp Val Glu Glu Thr Cys Glu Asn Ile Asn Glu Pro Gln Cys Pro Glu 
1               5                   10                  15      


Gly Phe Glu Met Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg 
            20                  25                  30          


Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys 
        35                  40                  45              


Leu Lys Lys Cys Gly Thr Tyr Ala Lys Asn Met Arg Pro Val Tyr Pro 
    50                  55                  60                  


Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro 
65                  70                  75                  80  


Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn 
                85                  90                  95      


Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr 
            100                 105                 110         


Lys Gly Glu Pro Ile Trp Leu Thr Ala Lys Tyr Gln Gly Leu Arg Ser 
        115                 120                 125             


Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Lys Ile Asn Gly Ile Phe 
    130                 135                 140                 


Pro Asp Ile Tyr Lys Ile Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg 
145                 150                 155                 160 


Ile Leu Ala Ile Leu Lys Trp Leu Arg Leu Pro Lys Asp Glu Arg Pro 
                165                 170                 175     


His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser 
            180                 185                 190         


Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp 
        195                 200                 205             


Asn Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His 
    210                 215                 220                 


Gln Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly 
225                 230                 235                 240 


Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Thr Lys 
                245                 250                 255     


Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp 
            260                 265                 270         


Val Pro Glu Lys Tyr Tyr Ser Phe Asn Tyr Glu Asn Ile Ala Arg Asn 
        275                 280                 285             


Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His 
    290                 295                 300                 


Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro 
305                 310                 315                 320 


Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Ser Pro Ser 
                325                 330                 335     


Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe 
            340                 345                 350         


Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Gln His 
        355                 360                 365             


Gly Ile Glu Val Asp Ser Phe Glu Asn Ile Glu Val Tyr Asn Leu Met 
    370                 375                 380                 


Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly 
385                 390                 395                 400 


Ser Leu Asn His Leu Leu Lys Asn Pro Ile Tyr Thr Pro Lys His Pro 
                405                 410                 415     


Lys Glu Val Gln Pro Ser Val Gln Cys Pro Leu Ala Gly Ser Pro Arg 
            420                 425                 430         


Asp Ser Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Val Asp 
        435                 440                 445             


Phe Gln Thr Gln Phe Asn Leu Thr Thr Ala Glu Glu Lys Asn Ile Asn 
    450                 455                 460                 


Arg Ala Ser Leu Pro Tyr Gly Arg Pro Arg Leu Leu Gln Lys Lys Ser 
465                 470                 475                 480 


Ser Val Cys Leu Leu Tyr Gln His Gln Phe Val Ser Gly Tyr Ser His 
                485                 490                 495     


Asp Val Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asn Arg Asn Asp 
            500                 505                 510         


Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Leu Arg 
        515                 520                 525             


Ile Ser Phe Ser Pro Ile His Asn Cys Ser Phe Tyr Lys Asn Asn Ala 
    530                 535                 540                 


Lys Leu Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Ser Lys Asp Ser 
545                 550                 555                 560 


Ser Gln Ile Tyr Ser Glu Ala Leu Leu Thr Ser Asn Ile Val Pro Met 
                565                 570                 575     


Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu 
            580                 585                 590         


Gln Arg Tyr Ala Glu Glu Arg Asn Ser Ile Asn Val Val Ser Gly Pro 
        595                 600                 605             


Val Phe Asp Ser Asp Tyr Asp Gly Arg Tyr Asp Ser Ser Glu Ala Leu 
    610                 615                 620                 


Lys Arg Asn Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr 
625                 630                 635                 640 


His Phe Phe Ile Val Ile Thr Ser Cys Lys Asn Thr Ser Gln Thr Pro 
                645                 650                 655     


Leu Gln Cys Asp Asn Leu Asp Pro Leu Ala Phe Ile Leu Pro His Arg 
            660                 665                 670         


Ser Asp Asn Ser Glu Ser Cys Val His Glu Lys Arg Glu Ser Ser Trp 
        675                 680                 685             


Ile Glu Glu Leu Leu Met Met His Arg Ala Arg Ile Met Asp Val Glu 
    690                 695                 700                 


His Ile Thr Gly Leu Ser Phe Tyr Gln Glu Arg Lys Glu Pro Val Ser 
705                 710                 715                 720 


Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Val Ser Gln Glu Asp 
                725                 730                 735     


<210> 7
<211> 736
<212> PRT
<213> Homo sapiens

<400> 7
Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala 
1               5                   10                  15      


Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg 
            20                  25                  30          


Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys 
        35                  40                  45              


Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro 
    50                  55                  60                  


Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro 
65                  70                  75                  80  


Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn 
                85                  90                  95      


Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr 
            100                 105                 110         


Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser 
        115                 120                 125             


Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe 
    130                 135                 140                 


Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg 
145                 150                 155                 160 


Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro 
                165                 170                 175     


His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser 
            180                 185                 190         


Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp 
        195                 200                 205             


Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His 
    210                 215                 220                 


Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly 
225                 230                 235                 240 


Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys 
                245                 250                 255     


Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp 
            260                 265                 270         


Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn 
        275                 280                 285             


Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His 
    290                 295                 300                 


Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro 
305                 310                 315                 320 


Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser 
                325                 330                 335     


Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe 
            340                 345                 350         


Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His 
        355                 360                 365             


Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met 
    370                 375                 380                 


Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly 
385                 390                 395                 400 


Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro 
                405                 410                 415     


Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg 
            420                 425                 430         


Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp 
        435                 440                 445             


Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys 
    450                 455                 460                 


His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn 
465                 470                 475                 480 


Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln 
                485                 490                 495     


Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp 
            500                 505                 510         


Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg 
        515                 520                 525             


Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr 
    530                 535                 540                 


Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser 
545                 550                 555                 560 


Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met 
                565                 570                 575     


Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu 
            580                 585                 590         


Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro 
        595                 600                 605             


Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu 
    610                 615                 620                 


Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr 
625                 630                 635                 640 


His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro 
                645                 650                 655     


Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg 
            660                 665                 670         


Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp 
        675                 680                 685             


Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu 
    690                 695                 700                 


His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser 
705                 710                 715                 720 


Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
                725                 730                 735     


<210> 8
<211> 736
<212> PRT
<213> Papio anubis

<400> 8
Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala 
1               5                   10                  15      


Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg 
            20                  25                  30          


Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys 
        35                  40                  45              


Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro 
    50                  55                  60                  


Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro 
65                  70                  75                  80  


Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn 
                85                  90                  95      


Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr 
            100                 105                 110         


Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser 
        115                 120                 125             


Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe 
    130                 135                 140                 


Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg 
145                 150                 155                 160 


Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro 
                165                 170                 175     


His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser 
            180                 185                 190         


Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp 
        195                 200                 205             


Asn Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His 
    210                 215                 220                 


Arg Cys Leu Asn Leu Ile Leu Val Ser Asp His Gly Met Glu Gln Gly 
225                 230                 235                 240 


Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys 
                245                 250                 255     


Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp 
            260                 265                 270         


Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn 
        275                 280                 285             


Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His 
    290                 295                 300                 


Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro 
305                 310                 315                 320 


Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser 
                325                 330                 335     


Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Ile Phe 
            340                 345                 350         


Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His 
        355                 360                 365             


Gly Ile Glu Val Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met 
    370                 375                 380                 


Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly 
385                 390                 395                 400 


Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro 
                405                 410                 415     


Lys Glu Val His Pro Leu Ile Gln Cys Pro Phe Thr Arg Asn Pro Arg 
            420                 425                 430         


Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp 
        435                 440                 445             


Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Asn Ile Lys 
    450                 455                 460                 


His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Lys Asn 
465                 470                 475                 480 


Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln 
                485                 490                 495     


Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp 
            500                 505                 510         


Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg 
        515                 520                 525             


Ile Ser Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr 
    530                 535                 540                 


Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser 
545                 550                 555                 560 


Arg Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met 
                565                 570                 575     


Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu 
            580                 585                 590         


Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro 
        595                 600                 605             


Val Phe Asp Phe Asp Tyr Asp Gly Arg Tyr Asp Ser Leu Glu Ile Leu 
    610                 615                 620                 


Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr 
625                 630                 635                 640 


His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Ala Ser Gln Thr Pro 
                645                 650                 655     


Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg 
            660                 665                 670         


Thr Asp Asn Ser Glu Ser Cys Leu His Gly Lys His Glu Ser Ser Trp 
        675                 680                 685             


Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu 
    690                 695                 700                 


His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser 
705                 710                 715                 720 


Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
                725                 730                 735     


<210> 9
<211> 966
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala 
1               5                   10                  15      


Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg 
            20                  25                  30          


Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys 
        35                  40                  45              


Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro 
    50                  55                  60                  


Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro 
65                  70                  75                  80  


Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn 
                85                  90                  95      


Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr 
            100                 105                 110         


Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser 
        115                 120                 125             


Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Thr Phe 
    130                 135                 140                 


Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg 
145                 150                 155                 160 


Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro 
                165                 170                 175     


His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser 
            180                 185                 190         


Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp 
        195                 200                 205             


Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His 
    210                 215                 220                 


Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly 
225                 230                 235                 240 


Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys 
                245                 250                 255     


Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp 
            260                 265                 270         


Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn 
        275                 280                 285             


Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His 
    290                 295                 300                 


Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro 
305                 310                 315                 320 


Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser 
                325                 330                 335     


Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe 
            340                 345                 350         


Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His 
        355                 360                 365             


Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met 
    370                 375                 380                 


Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly 
385                 390                 395                 400 


Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro 
                405                 410                 415     


Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg 
            420                 425                 430         


Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp 
        435                 440                 445             


Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys 
    450                 455                 460                 


His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn 
465                 470                 475                 480 


Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln 
                485                 490                 495     


Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp 
            500                 505                 510         


Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg 
        515                 520                 525             


Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr 
    530                 535                 540                 


Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser 
545                 550                 555                 560 


Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met 
                565                 570                 575     


Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu 
            580                 585                 590         


Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro 
        595                 600                 605             


Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu 
    610                 615                 620                 


Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr 
625                 630                 635                 640 


His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro 
                645                 650                 655     


Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg 
            660                 665                 670         


Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp 
        675                 680                 685             


Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu 
    690                 695                 700                 


His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser 
705                 710                 715                 720 


Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
                725                 730                 735     


Leu Ile Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            740                 745                 750         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        755                 760                 765             


Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp 
    770                 775                 780                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
785                 790                 795                 800 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                805                 810                 815     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            820                 825                 830         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        835                 840                 845             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    850                 855                 860                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
865                 870                 875                 880 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                885                 890                 895     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            900                 905                 910         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        915                 920                 925             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    930                 935                 940                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
945                 950                 955                 960 


Ser Leu Ser Pro Gly Lys 
                965     


<210> 10
<211> 987
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Unprocessed ENPP1(190-925)-hFc protein sequence"

<400> 10
Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Lys Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu 
            20                  25                  30          


Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser 
        35                  40                  45              


Leu Asp Gly Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu 
    50                  55                  60                  


Pro Val Ile Ser Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met 
65                  70                  75                  80  


Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val 
                85                  90                  95      


Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr 
            100                 105                 110         


Asp Pro Lys Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe 
        115                 120                 125             


Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr 
    130                 135                 140                 


Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu 
145                 150                 155                 160 


Ile Asn Gly Thr Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val 
                165                 170                 175     


Pro Phe Glu Glu Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro 
            180                 185                 190         


Lys Asp Glu Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp 
        195                 200                 205             


Ser Ser Gly His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala 
    210                 215                 220                 


Leu Gln Arg Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys 
225                 230                 235                 240 


Glu Leu Asn Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His 
                245                 250                 255     


Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr 
            260                 265                 270         


Leu Gly Asp Val Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg 
        275                 280                 285             


Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu 
    290                 295                 300                 


Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys 
305                 310                 315                 320 


Pro Tyr Leu Lys His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser 
                325                 330                 335     


Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu 
            340                 345                 350         


Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly 
        355                 360                 365             


Ser Asp Asn Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly 
    370                 375                 380                 


Pro Gly Phe Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu 
385                 390                 395                 400 


Val Tyr Asn Leu Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn 
                405                 410                 415     


Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr 
            420                 425                 430         


Thr Pro Lys His Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe 
        435                 440                 445             


Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile 
    450                 455                 460                 


Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu 
465                 470                 475                 480 


Glu Lys Ile Ile Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val 
                485                 490                 495     


Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met 
            500                 505                 510         


Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr 
        515                 520                 525             


Val Asp Arg Asn Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu 
    530                 535                 540                 


Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe 
545                 550                 555                 560 


Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln 
                565                 570                 575     


Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr 
            580                 585                 590         


Asn Ile Val Pro Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe 
        595                 600                 605             


His Asp Thr Leu Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn 
    610                 615                 620                 


Val Val Ser Gly Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp 
625                 630                 635                 640 


Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu 
                645                 650                 655     


Ile Leu Ile Pro Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp 
            660                 665                 670         


Thr Ser Gln Thr Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe 
        675                 680                 685             


Ile Leu Pro His Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys 
    690                 695                 700                 


His Asp Ser Ser Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg 
705                 710                 715                 720 


Ile Thr Asp Val Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg 
                725                 730                 735     


Lys Glu Pro Val Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr 
            740                 745                 750         


Phe Ser Gln Glu Asp Leu Ile Asn Asp Lys Thr His Thr Cys Pro Pro 
        755                 760                 765             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    770                 775                 780                 


Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr 
785                 790                 795                 800 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                805                 810                 815     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            820                 825                 830         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        835                 840                 845             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    850                 855                 860                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
865                 870                 875                 880 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                885                 890                 895     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            900                 905                 910         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        915                 920                 925             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    930                 935                 940                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
945                 950                 955                 960 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                965                 970                 975     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 985         


<210> 11
<211> 966
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 11
Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala 
1               5                   10                  15      


Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg 
            20                  25                  30          


Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys 
        35                  40                  45              


Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro 
    50                  55                  60                  


Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro 
65                  70                  75                  80  


Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn 
                85                  90                  95      


Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr 
            100                 105                 110         


Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser 
        115                 120                 125             


Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Thr Phe 
    130                 135                 140                 


Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg 
145                 150                 155                 160 


Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro 
                165                 170                 175     


His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser 
            180                 185                 190         


Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp 
        195                 200                 205             


Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His 
    210                 215                 220                 


Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly 
225                 230                 235                 240 


Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys 
                245                 250                 255     


Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp 
            260                 265                 270         


Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn 
        275                 280                 285             


Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His 
    290                 295                 300                 


Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro 
305                 310                 315                 320 


Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser 
                325                 330                 335     


Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe 
            340                 345                 350         


Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His 
        355                 360                 365             


Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met 
    370                 375                 380                 


Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly 
385                 390                 395                 400 


Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro 
                405                 410                 415     


Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg 
            420                 425                 430         


Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp 
        435                 440                 445             


Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys 
    450                 455                 460                 


His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn 
465                 470                 475                 480 


Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln 
                485                 490                 495     


Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp 
            500                 505                 510         


Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg 
        515                 520                 525             


Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr 
    530                 535                 540                 


Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser 
545                 550                 555                 560 


Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met 
                565                 570                 575     


Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu 
            580                 585                 590         


Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro 
        595                 600                 605             


Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu 
    610                 615                 620                 


Arg Gln Lys Arg His Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr 
625                 630                 635                 640 


His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro 
                645                 650                 655     


Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg 
            660                 665                 670         


Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp 
        675                 680                 685             


Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu 
    690                 695                 700                 


His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser 
705                 710                 715                 720 


Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
                725                 730                 735     


Leu Ile Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            740                 745                 750         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        755                 760                 765             


Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp 
    770                 775                 780                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
785                 790                 795                 800 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                805                 810                 815     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            820                 825                 830         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        835                 840                 845             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    850                 855                 860                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
865                 870                 875                 880 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                885                 890                 895     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            900                 905                 910         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        915                 920                 925             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    930                 935                 940                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
945                 950                 955                 960 


Ser Leu Ser Pro Gly Lys 
                965     


<210> 12
<211> 987
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Lys Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu 
            20                  25                  30          


Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser 
        35                  40                  45              


Leu Asp Gly Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu 
    50                  55                  60                  


Pro Val Ile Ser Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met 
65                  70                  75                  80  


Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val 
                85                  90                  95      


Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr 
            100                 105                 110         


Asp Pro Lys Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe 
        115                 120                 125             


Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr 
    130                 135                 140                 


Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu 
145                 150                 155                 160 


Ile Asn Gly Thr Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val 
                165                 170                 175     


Pro Phe Glu Glu Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro 
            180                 185                 190         


Lys Asp Glu Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp 
        195                 200                 205             


Ser Ser Gly His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala 
    210                 215                 220                 


Leu Gln Arg Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys 
225                 230                 235                 240 


Glu Leu Asn Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His 
                245                 250                 255     


Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr 
            260                 265                 270         


Leu Gly Asp Val Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg 
        275                 280                 285             


Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu 
    290                 295                 300                 


Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys 
305                 310                 315                 320 


Pro Tyr Leu Lys His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser 
                325                 330                 335     


Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu 
            340                 345                 350         


Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly 
        355                 360                 365             


Ser Asp Asn Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly 
    370                 375                 380                 


Pro Gly Phe Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu 
385                 390                 395                 400 


Val Tyr Asn Leu Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn 
                405                 410                 415     


Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr 
            420                 425                 430         


Thr Pro Lys His Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe 
        435                 440                 445             


Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile 
    450                 455                 460                 


Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu 
465                 470                 475                 480 


Glu Lys Ile Ile Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val 
                485                 490                 495     


Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met 
            500                 505                 510         


Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr 
        515                 520                 525             


Val Asp Arg Asn Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu 
    530                 535                 540                 


Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe 
545                 550                 555                 560 


Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln 
                565                 570                 575     


Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr 
            580                 585                 590         


Asn Ile Val Pro Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe 
        595                 600                 605             


His Asp Thr Leu Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn 
    610                 615                 620                 


Val Val Ser Gly Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp 
625                 630                 635                 640 


Ser Leu Glu Asn Leu Arg Gln Lys Arg His Val Ile Arg Asn Gln Glu 
                645                 650                 655     


Ile Leu Ile Pro Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp 
            660                 665                 670         


Thr Ser Gln Thr Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe 
        675                 680                 685             


Ile Leu Pro His Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys 
    690                 695                 700                 


His Asp Ser Ser Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg 
705                 710                 715                 720 


Ile Thr Asp Val Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg 
                725                 730                 735     


Lys Glu Pro Val Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr 
            740                 745                 750         


Phe Ser Gln Glu Asp Leu Ile Asn Asp Lys Thr His Thr Cys Pro Pro 
        755                 760                 765             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    770                 775                 780                 


Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr 
785                 790                 795                 800 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                805                 810                 815     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            820                 825                 830         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        835                 840                 845             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    850                 855                 860                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
865                 870                 875                 880 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                885                 890                 895     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            900                 905                 910         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        915                 920                 925             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    930                 935                 940                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
945                 950                 955                 960 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                965                 970                 975     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 985         


<210> 13
<211> 227
<212> PRT
<213> Homo sapiens

<400> 13
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
            20                  25                  30          


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 14
<211> 2985
<212> DNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      ENPP1-Fc nucleotide sequence"

<400> 14
ggtaccgcca ccatgacaag actgacagtg ctggctctgc tggccggact gttggcctct       60

tctagagcta agtcctgggt tgaagaaccc tgcgagtcca tcaacgagcc tcagtgtcct      120

gccggcttcg agacacctcc tactctgctg ttctccctgg atggcttcag agccgagtac      180

ctgcatactt ggggaggcct gctgccagtg atctccaagc tgaagaagtg cggcacctac      240

accaagaaca tgaggcctgt gtaccctacc aagacattcc ccaaccacta ctccatcgtg      300

accggcctgt atcctgagag ccacggcatc atcgacaaca agatgtacga ccccaagatg      360

aacgcctcct tcagcctgaa gtccaaagag aagttcaacc ccgagtggta taagggcgag      420

cctatctggg tcaccgctaa gtaccaggga ctgaagtctg gcaccttctt ttggcctggc      480

tccgacgtgg aaatcaacgg caccttcccc gacatctata agatgtacaa cggctccgtg      540

cctttcgagg aacgcattct ggctgttctg cagtggctgc agctgcctaa ggatgagagg      600

cctcacttct acaccctgta cctggaagaa cctgactcct ccggccactc ttatggccct      660

gtgtcctctg aagtgatcaa ggccctgcag cgagtggacg gaatggtcgg aatgctgatg      720

gacggcctga aagagctgaa cctgcacaga tgcctgaacc tgatcctgat ctccgaccac      780

ggcatggaac aggggagctg caagaagtac atctacctga acaagtacct gggcgacgtg      840

aagaacatca aagtgatcta cggcccagcc gccagactga ggccttctga tgtgcctgac      900

aagtactact ccttcaacta cgagggaatc gcccggaacc tgtcctgcag agagcctaac      960

cagcacttca agccctacct gaagcacttt ctgcctaagc ggctgcactt cgccaagtct     1020

gacagaatcg agcccctgac cttctatctg gaccctcagt ggcagctggc cctgaatcct     1080

agcgagagaa agtactgtgg ctccggcttc cacggctccg acaacgtgtt ctctaatatg     1140

caggccctgt tcgtcggcta cggccctggc tttaaacacg gcatcgaggc cgacaccttc     1200

gagaacatcg aggtgtacaa tctgatgtgt gacctgctga atctgacccc tgctcctaac     1260

aacggcaccc acggatctct gaaccatctg ctgaagaatc ccgtgtacac ccctaagcac     1320

cccaaagagg ttcaccctct ggtccagtgt cctttcacca gaaatcctcg ggacaacctg     1380

ggctgctctt gcaacccttc tatcctgcct atcgaggact ttcagaccca gttcaacctg     1440

accgtggccg aggaaaagat catcaagcac gagacactgc cctacggcag acctagagtg     1500

ctgcagaaag agaacaccat ctgcctgctg tcccagcacc agttcatgtc cggctactcc     1560

caggacatcc tgatgcctct gtggacctcc tacaccgtgg accggaacga tagcttctcc     1620

accgaggact tcagcaactg cctgtaccag gatttcagaa tccctctgag ccccgtgcac     1680

aagtgcagct tctacaagaa caacaccaag gtgtcctacg gcttcctgtc tcctccacag     1740

ctgaacaaga actccagcgg catctactct gaggccctgc tgaccaccaa catcgtgccc     1800

atgtaccagt ccttccaagt gatctggcgg tacttccacg acaccctgct gaggaagtac     1860

gccgaagaaa gaaacggcgt gaacgtggtg tctggccccg tgttcgactt cgactacgac     1920

ggcagatgcg actctctgga aaacctgcgg cagaaaagac gagtgatccg gaatcaagag     1980

atcctgattc ctacacactt ctttatcgtg ctgaccagct gcaaggatac ctctcagacc     2040

cctctgcact gcgagaatct ggacaccctg gccttcattc tgcctcacag aaccgacaac     2100

tccgagtcct gtgtgcacgg caagcacgac tcctcttggg tcgaagaact gctgatgctg     2160

caccgggcca gaatcaccga tgtggaacac atcaccggcc tgagcttcta ccagcagcgg     2220

aaagaacctg tgtccgatat cctgaagctg aaaacccatc tgccaacctt cagccaagag     2280

gacctgatca acgacaagac ccacacctgt cctccatgtc ctgctccaga actgctcgga     2340

ggcccctctg tgttcctgtt tccacctaag ccaaaggaca cactgtacat cactcgggag     2400

cctgaagtga cctgcgtggt ggtggatgtg tctcacgaag atcccgaagt caagttcaat     2460

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagtac     2520

aactccacct acagagtggt gtccgtgctg actgtgctgc accaggattg gctgaacggc     2580

aaagagtaca agtgcaaagt gtccaacaag gctctgcccg ctcctatcga aaagaccatc     2640

tccaaggcta agggccagcc tcgggaacct caggtttaca ccctgcctcc atctcgggaa     2700

gagatgacca agaaccaggt gtccctgacc tgcctggtca agggcttcta cccttccgat     2760

atcgccgtgg aatgggagtc caatggccag cctgagaaca actacaagac aacccctcct     2820

gtgctggaca gcgacggctc attcttcctg tactctaagc tgacagtgga caagtcccgg     2880

tggcagcaag gcaatgtgtt ttcctgctct gtgatgcacg aggccctcca caatcactac     2940

acccagaagt ccctgtctct gtcccctggc aaatgatagc tcgag                     2985


<210> 15
<211> 2985
<212> DNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      ENPP1-Fc nucleotide sequence"

<400> 15
ggtaccgcca ccatgacaag actgacagtg ctggctctgc tggccggact gttggcctct       60

tctagagcta agtcctgggt tgaagaaccc tgcgagtcca tcaacgagcc tcagtgtcct      120

gccggcttcg agacacctcc tactctgctg ttctccctgg atggcttcag agccgagtac      180

ctgcatactt ggggaggcct gctgccagtg atctccaagc tgaagaagtg cggcacctac      240

accaagaaca tgaggcctgt gtaccctacc aagacattcc ccaaccacta ctccatcgtg      300

accggcctgt atcctgagag ccacggcatc atcgacaaca agatgtacga ccccaagatg      360

aacgcctcct tcagcctgaa gtccaaagag aagttcaacc ccgagtggta taagggcgag      420

cctatctggg tcaccgctaa gtaccaggga ctgaagtctg gcaccttctt ttggcctggc      480

tccgacgtgg aaatcaacgg caccttcccc gacatctata agatgtacaa cggctccgtg      540

cctttcgagg aacgcattct ggctgttctg cagtggctgc agctgcctaa ggatgagagg      600

cctcacttct acaccctgta cctggaagaa cctgactcct ccggccactc ttatggccct      660

gtgtcctctg aagtgatcaa ggccctgcag cgagtggacg gaatggtcgg aatgctgatg      720

gacggcctga aagagctgaa cctgcacaga tgcctgaacc tgatcctgat ctccgaccac      780

ggcatggaac aggggagctg caagaagtac atctacctga acaagtacct gggcgacgtg      840

aagaacatca aagtgatcta cggcccagcc gccagactga ggccttctga tgtgcctgac      900

aagtactact ccttcaacta cgagggaatc gcccggaacc tgtcctgcag agagcctaac      960

cagcacttca agccctacct gaagcacttt ctgcctaagc ggctgcactt cgccaagtct     1020

gacagaatcg agcccctgac cttctatctg gaccctcagt ggcagctggc cctgaatcct     1080

agcgagagaa agtactgtgg ctccggcttc cacggctccg acaacgtgtt ctctaatatg     1140

caggccctgt tcgtcggcta cggccctggc tttaaacacg gcatcgaggc cgacaccttc     1200

gagaacatcg aggtgtacaa tctgatgtgt gacctgctga atctgacccc tgctcctaac     1260

aacggcaccc acggatctct gaaccatctg ctgaagaatc ccgtgtacac ccctaagcac     1320

cccaaagagg ttcaccctct ggtccagtgt cctttcacca gaaatcctcg ggacaacctg     1380

ggctgctctt gcaacccttc tatcctgcct atcgaggact ttcagaccca gttcaacctg     1440

accgtggccg aggaaaagat catcaagcac gagacactgc cctacggcag acctagagtg     1500

ctgcagaaag agaacaccat ctgcctgctg tcccagcacc agttcatgtc cggctactcc     1560

caggacatcc tgatgcctct gtggacctcc tacaccgtgg accggaacga tagcttctcc     1620

accgaggact tcagcaactg cctgtaccag gatttcagaa tccctctgag ccccgtgcac     1680

aagtgcagct tctacaagaa caacaccaag gtgtcctacg gcttcctgtc tcctccacag     1740

ctgaacaaga actccagcgg catctactct gaggccctgc tgaccaccaa catcgtgccc     1800

atgtaccagt ccttccaagt gatctggcgg tacttccacg acaccctgct gaggaagtac     1860

gccgaagaaa gaaacggcgt gaacgtggtg tctggccccg tgttcgactt cgactacgac     1920

ggcagatgcg actctctgga aaacctgcgg cagaaaagac acgtgatccg gaatcaagag     1980

atcctgattc ctacacactt ctttatcgtg ctgaccagct gcaaggatac ctctcagacc     2040

cctctgcact gcgagaatct ggacaccctg gccttcattc tgcctcacag aaccgacaac     2100

tccgagtcct gtgtgcacgg caagcacgac tcctcttggg tcgaagaact gctgatgctg     2160

caccgggcca gaatcaccga tgtggaacac atcaccggcc tgagcttcta ccagcagcgg     2220

aaagaacctg tgtccgatat cctgaagctg aaaacccatc tgccaacctt cagccaagag     2280

gacctgatca acgacaagac ccacacctgt cctccatgtc ctgctccaga actgctcgga     2340

ggcccctctg tgttcctgtt tccacctaag ccaaaggaca cactgtacat cactcgggag     2400

cctgaagtga cctgcgtggt ggtggatgtg tctcacgaag atcccgaagt caagttcaat     2460

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagtac     2520

aactccacct acagagtggt gtccgtgctg actgtgctgc accaggattg gctgaacggc     2580

aaagagtaca agtgcaaagt gtccaacaag gctctgcccg ctcctatcga aaagaccatc     2640

tccaaggcta agggccagcc tcgggaacct caggtttaca ccctgcctcc atctcgggaa     2700

gagatgacca agaaccaggt gtccctgacc tgcctggtca agggcttcta cccttccgat     2760

atcgccgtgg aatgggagtc caatggccag cctgagaaca actacaagac aacccctcct     2820

gtgctggaca gcgacggctc attcttcctg tactctaagc tgacagtgga caagtcccgg     2880

tggcagcaag gcaatgtgtt ttcctgctct gtgatgcacg aggccctcca caatcactac     2940

acccagaagt ccctgtctct gtcccctggc aaatgatagc tcgag                     2985


<210> 16
<211> 227
<212> PRT
<213> Homo sapiens

<400> 16
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 17
<211> 24
<212> PRT
<213> Homo sapiens


<220>
<221> VARIANT
<222> (23)..(23)
<223> /replace=" "

<220>
<221> VARIANT
<222> (24)..(24)
<223> /replace=" "

<220>
<221> SITE
<222> (1)..(24)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 17
Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser Leu Gln 
            20                  


<210> 18
<211> 22
<212> PRT
<213> Homo sapiens

<400> 18
Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Ala 
            20          


<210> 19
<211> 20
<212> PRT
<213> Homo sapiens

<400> 19
Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala 
            20  


<210> 20
<211> 19
<212> PRT
<213> Homo sapiens

<400> 20
Ile Ile Ser Leu Phe Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly 
1               5                   10                  15      


Phe Thr Ala 
            


<210> 21
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Gly Ala 
1       


<210> 22
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 22
Gly Ser 
1       


<210> 23
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Gly Gly 
1       


<210> 24
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Gly Gly Ala 
1           


<210> 25
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Gly Gly Ser 
1           


<210> 26
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Gly Gly Gly 
1           


<210> 27
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Gly Gly Gly Ala 
1               


<210> 28
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Gly Gly Gly Ser 
1               


<210> 29
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Gly Gly Gly Gly 
1               


<210> 30
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Gly Gly Gly Gly Ala 
1               5   


<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Gly Gly Gly Gly Ser 
1               5   


<210> 32
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Gly Gly Gly Gly Gly 
1               5   


<210> 33
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Gly Gly Ala Gly 
1               


<210> 34
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Gly Gly Ser Gly 
1               


<210> 35
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Ala Gly Gly Gly 
1               


<210> 36
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Ser Gly Gly Gly Gly 
1               5   


<210> 37
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Ser Gly Gly Gly 
1               


<210> 38
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Gly Ala Gly Ala 
1               


<210> 39
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Gly Ser Gly Ser 
1               


<210> 40
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Gly Ala Gly Ala Gly Ala 
1               5       


<210> 41
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Gly Ser Gly Ser Gly Ser 
1               5       


<210> 42
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Gly Ala Gly Ala Gly Ala Gly Ala 
1               5               


<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210> 44
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10  


<210> 45
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210> 46
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10          


<210> 47
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10          


<210> 48
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Gly Gly Ala Gly Gly Ala 
1               5       


<210> 49
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Gly Gly Ser Gly Gly Ser 
1               5       


<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Gly Gly Ala Gly Gly Ala Gly Gly Ala 
1               5                   


<210> 51
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   


<210> 52
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Ala 
1               5                   10          


<210> 53
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210> 54
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Gly Gly Ala Gly 
1               


<210> 55
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Gly Gly Ser Gly 
1               


<210> 56
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Gly Gly Ala Gly 
1               


<210> 57
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Gly Gly Ser Gly 
1               


<210> 58
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Gly Gly Ala Gly Gly Gly Ala Gly 
1               5               


<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Gly Gly Ser Gly Gly Gly Ser Gly 
1               5               


<210> 60
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly Ala Gly 
1               5                   10          


<210> 61
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 61
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10          


<210> 62
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
Gly Gly Gly Gly Ala 
1               5   


<210> 63
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Gly Gly Gly Gly Ser 
1               5   


<210> 64
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala 
1               5                   10                  15  


<210> 65
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 65
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 66
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Gly Gly Gly Ala Gly 
1               5   


<210> 67
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 67
Gly Gly Gly Ala Gly Gly 
1               5       


<210> 68
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 68
Gly Gly Gly Ala Gly Gly Gly 
1               5           


<210> 69
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 69
Leu Ile Asn 
1           


<210> 70
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 70
Thr Gly Gly Gly Gly 
1               5   


<210> 71
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 71
Ala Ala Ala Leu 
1               


<210> 72
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 72
Ala Ala Ala Lys 
1               


<210> 73
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Ala Ala Ala Arg 
1               


<210> 74
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 74
Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210> 75
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 75
Gly Ser Ala Gly Ser Ala Ala Gly Ser Gly Glu Phe 
1               5                   10          


<210> 76
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 76
Ala Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Ala 
1               5                   10          


<210> 77
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 77
Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210> 78
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 78
Gly Glu Asn Leu Tyr Phe Gln Ser Gly Gly 
1               5                   10  


<210> 79
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 79
Ser Ala Cys Tyr Cys Glu Leu Ser 
1               5               


<210> 80
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 80
Arg Ser Ile Ala Thr 
1               5   


<210> 81
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 81
Arg Pro Ala Cys Lys Ile Pro Asn Asp Leu Lys Gln Lys Val Met Asn 
1               5                   10                  15      


His 
    


<210> 82
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 82
Gly Gly Ser Ala Gly Gly Ser Gly Ser Gly Ser Ser Gly Gly Ser Ser 
1               5                   10                  15      


Gly Ala Ser Gly Thr Gly Thr Ala Gly Gly Thr Gly Ser Gly Ser Gly 
            20                  25                  30          


Thr Gly Ser Gly 
        35      


<210> 83
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 83
Ala Ala Ala Asn Ser Ser Ile Asp Leu Ile Ser Val Pro Val Asp Ser 
1               5                   10                  15      


Arg 
    


<210> 84
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 84
Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly 
1               5                   10                  15      


Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser 
        35      


<210> 85
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 85
Glu Ala Ala Ala Lys 
1               5   


<210> 86
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 86
Pro Ala Pro Ala Pro 
1               5   


<210> 87
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 87
Asn Ser Ser 
1           


<210> 88
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 88
Glu Ser Ser 
1           


<210> 89
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 89
Arg Gln Gln 
1           


<210> 90
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 90
Lys Arg 
1       


<210> 91
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(15)
<223> /note="This sequence may encompass 0-15 residues"

<400> 91
Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15  


<210> 92
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 92
Asp Ser Ser Ser Glu Glu Lys Phe Leu Arg Arg Ile Gly Arg Phe Gly 
1               5                   10                  15      


<210> 93
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 93
Glu Glu Glu Glu Glu Glu Glu Pro Arg Gly Asp Thr 
1               5                   10          


<210> 94
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 94
Ala Pro Trp His Leu Ser Ser Gln Tyr Ser Arg Thr 
1               5                   10          


<210> 95
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 95
Ser Thr Leu Pro Ile Pro His Glu Phe Ser Arg Glu 
1               5                   10          


<210> 96
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 96
Val Thr Lys His Leu Asn Gln Ile Ser Gln Ser Tyr 
1               5                   10          


<210> 97
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(15)
<223> /note="This sequence may encompass 1-15 residues"

<400> 97
Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
1               5                   10                  15  


<210> 98
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 98
Arg Ser Gly Ser Gly Gly Ser 
1               5           


<210> 99
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(15)
<223> /note="This sequence may encompass 1-15 residues"

<400> 99
Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
1               5                   10                  15  


<210> 100
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 100
Leu Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10                  15      


<210> 101
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 101
Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10                  15  


<210> 102
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 102
Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10                  


<210> 103
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 103
Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10              


<210> 104
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 104
Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10          


<210> 105
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 105
Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10      


<210> 106
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 106
Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10  


<210> 107
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 107
Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   


<210> 108
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 108
Gly Leu Gly Leu Gly Leu Arg Lys 
1               5               


<210> 109
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 109
Leu Gly Leu Gly Leu Arg Lys 
1               5           


<210> 110
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 110
Gly Leu Gly Leu Arg Lys 
1               5       


<210> 111
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 111
Leu Gly Leu Arg Lys 
1               5   


<210> 112
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 112
Gly Leu Arg Lys 
1               


<210> 113
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 113
Leu Arg Lys 
1           


<210> 114
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 114
Arg Lys 
1       


<210> 115
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(15)
<223> /note="This sequence may encompass 1-15 residues"

<400> 115
Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15  


<210> 116
<211> 875
<212> PRT
<213> Homo sapiens

<400> 116
Met Glu Ser Thr Leu Thr Leu Ala Thr Glu Gln Pro Val Lys Lys Asn 
1               5                   10                  15      


Thr Leu Lys Lys Tyr Lys Ile Ala Cys Ile Val Leu Leu Ala Leu Leu 
            20                  25                  30          


Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys Leu 
        35                  40                  45              


Glu Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg 
    50                  55                  60                  


Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp 
65                  70                  75                  80  


Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp 
                85                  90                  95      


Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu Ala Ser Leu 
            100                 105                 110         


Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Ala Asp 
        115                 120                 125             


Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys 
    130                 135                 140                 


Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro 
145                 150                 155                 160 


Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr 
                165                 170                 175     


Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile 
            180                 185                 190         


His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn 
        195                 200                 205             


His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile 
    210                 215                 220                 


Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser 
225                 230                 235                 240 


Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp 
                245                 250                 255     


Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro 
            260                 265                 270         


Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro 
        275                 280                 285             


Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys 
    290                 295                 300                 


Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr 
305                 310                 315                 320 


Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala 
                325                 330                 335     


Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu 
            340                 345                 350         


Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile 
        355                 360                 365             


Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu 
    370                 375                 380                 


Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu 
385                 390                 395                 400 


Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe 
                405                 410                 415     


Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro 
            420                 425                 430         


Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
        435                 440                 445             


His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp 
    450                 455                 460                 


Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly 
465                 470                 475                 480 


Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe 
                485                 490                 495     


Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe 
            500                 505                 510         


Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln 
        515                 520                 525             


Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys 
    530                 535                 540                 


Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser 
545                 550                 555                 560 


Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe 
                565                 570                 575     


Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met 
            580                 585                 590         


Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu 
        595                 600                 605             


Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu 
    610                 615                 620                 


Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met 
625                 630                 635                 640 


Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro 
                645                 650                 655     


Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro 
            660                 665                 670         


Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile 
        675                 680                 685             


Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser 
    690                 695                 700                 


Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu 
705                 710                 715                 720 


Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His 
                725                 730                 735     


Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
            740                 745                 750         


Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His 
        755                 760                 765             


Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu 
    770                 775                 780                 


Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp 
785                 790                 795                 800 


Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu 
                805                 810                 815     


Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe 
            820                 825                 830         


Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu 
        835                 840                 845             


Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu 
    850                 855                 860                 


Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile 
865                 870                 875 


<210> 117
<211> 1057
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 117
Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Asn Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Val Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Ile Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Val Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Ile Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Asn Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Leu Ile Asn Asp Lys 
            820                 825                 830         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        835                 840                 845             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    850                 855                 860                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
865                 870                 875                 880 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                885                 890                 895     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            900                 905                 910         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        915                 920                 925             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    930                 935                 940                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
945                 950                 955                 960 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                965                 970                 975     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            980                 985                 990         


Ser Asn Gly Gln Pro Glu Asn Asn  Tyr Lys Thr Thr Pro  Pro Val Leu 
        995                 1000                 1005             


Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser Lys Leu  Thr Val Asp 
    1010                 1015                 1020             


Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe Ser Cys  Ser Val Met 
    1025                 1030                 1035             


His Glu  Ala Leu His Asn His  Tyr Thr Gln Lys Ser  Leu Ser Leu 
    1040                 1045                 1050             


Ser Pro  Gly Lys 
    1055         


<210> 118
<211> 1057
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 118
Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Lys Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Ser Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Tyr Asp Ser Leu Glu Ile Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Ala Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Glu Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Leu Ile Asn Asp Lys 
            820                 825                 830         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        835                 840                 845             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    850                 855                 860                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
865                 870                 875                 880 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                885                 890                 895     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            900                 905                 910         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        915                 920                 925             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    930                 935                 940                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
945                 950                 955                 960 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                965                 970                 975     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            980                 985                 990         


Ser Asn Gly Gln Pro Glu Asn Asn  Tyr Lys Thr Thr Pro  Pro Val Leu 
        995                 1000                 1005             


Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser Lys Leu  Thr Val Asp 
    1010                 1015                 1020             


Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe Ser Cys  Ser Val Met 
    1025                 1030                 1035             


His Glu  Ala Leu His Asn His  Tyr Thr Gln Lys Ser  Leu Ser Leu 
    1040                 1045                 1050             


Ser Pro  Gly Lys 
    1055         


<210> 119
<211> 1059
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 119
Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Gly Gly Gly Gly Ser 
            820                 825                 830         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        835                 840                 845             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    850                 855                 860                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
865                 870                 875                 880 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                885                 890                 895     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            900                 905                 910         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        915                 920                 925             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    930                 935                 940                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
945                 950                 955                 960 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                965                 970                 975     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            980                 985                 990         


Trp Glu Ser Asn Gly Gln Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro 
        995                 1000                 1005             


Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr 
    1010                 1015                 1020             


Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser 
    1025                 1030                 1035             


Val Met  His Glu Ala Leu His  Asn His Tyr Thr Gln  Lys Ser Leu 
    1040                 1045                 1050             


Ser Leu  Ser Pro Gly Lys 
    1055                 


<210> 120
<211> 1059
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 120
Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu 
1               5                   10                  15      


Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly 
            20                  25                  30          


Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile 
        35                  40                  45              


Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser 
    50                  55                  60                  


Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile 
65                  70                  75                  80  


Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro 
                85                  90                  95      


Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro 
            100                 105                 110         


Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His 
        115                 120                 125             


Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly 
    130                 135                 140                 


Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro 
145                 150                 155                 160 


Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile 
                165                 170                 175     


Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu 
            180                 185                 190         


Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile 
        195                 200                 205             


Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp 
    210                 215                 220                 


Pro Gly Ser Asp Val Glu Ile Asn Gly Thr Phe Pro Asp Ile Tyr Lys 
225                 230                 235                 240 


Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala Val Leu 
                245                 250                 255     


Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr Thr Leu 
            260                 265                 270         


Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro Val Ser 
        275                 280                 285             


Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val Gly Met 
    290                 295                 300                 


Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu Asn Leu 
305                 310                 315                 320 


Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr 
                325                 330                 335     


Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys Val Ile 
            340                 345                 350         


Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr 
        355                 360                 365             


Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu 
    370                 375                 380                 


Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro Lys Arg 
385                 390                 395                 400 


Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu 
                405                 410                 415     


Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys 
            420                 425                 430         


Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met Gln Ala 
        435                 440                 445             


Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu Ala Asp 
    450                 455                 460                 


Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Asn 
465                 470                 475                 480 


Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
                485                 490                 495     


Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val His Pro 
            500                 505                 510         


Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys 
        515                 520                 525             


Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe 
    530                 535                 540                 


Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr Leu Pro 
545                 550                 555                 560 


Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu 
                565                 570                 575     


Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro 
            580                 585                 590         


Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser Thr Glu 
        595                 600                 605             


Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro 
    610                 615                 620                 


Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly 
625                 630                 635                 640 


Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser 
                645                 650                 655     


Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser Phe Gln 
            660                 665                 670         


Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr Ala Glu 
        675                 680                 685             


Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp Phe Asp 
    690                 695                 700                 


Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg 
705                 710                 715                 720 


Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe Ile Val 
                725                 730                 735     


Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys Glu Asn 
            740                 745                 750         


Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn Ser Glu 
        755                 760                 765             


Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu Leu Leu 
    770                 775                 780                 


Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr Gly Leu 
785                 790                 795                 800 


Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu Lys Leu 
                805                 810                 815     


Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Gly Gly Gly Gly Ser 
            820                 825                 830         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        835                 840                 845             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
    850                 855                 860                 


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
865                 870                 875                 880 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                885                 890                 895     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            900                 905                 910         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        915                 920                 925             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    930                 935                 940                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
945                 950                 955                 960 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                965                 970                 975     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            980                 985                 990         


Trp Glu Ser Asn Gly Gln Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro 
        995                 1000                 1005             


Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr 
    1010                 1015                 1020             


Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser 
    1025                 1030                 1035             


Val Met  His Glu Ala Leu His  Asn His Tyr Thr Gln  Lys Ser Leu 
    1040                 1045                 1050             


Ser Leu  Ser Pro Gly Lys 
    1055                 


<210> 121
<211> 968
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 121
Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala 
1               5                   10                  15      


Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg 
            20                  25                  30          


Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys 
        35                  40                  45              


Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro 
    50                  55                  60                  


Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro 
65                  70                  75                  80  


Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn 
                85                  90                  95      


Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr 
            100                 105                 110         


Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser 
        115                 120                 125             


Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Thr Phe 
    130                 135                 140                 


Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg 
145                 150                 155                 160 


Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro 
                165                 170                 175     


His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser 
            180                 185                 190         


Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp 
        195                 200                 205             


Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His 
    210                 215                 220                 


Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly 
225                 230                 235                 240 


Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys 
                245                 250                 255     


Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp 
            260                 265                 270         


Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn 
        275                 280                 285             


Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His 
    290                 295                 300                 


Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro 
305                 310                 315                 320 


Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser 
                325                 330                 335     


Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe 
            340                 345                 350         


Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His 
        355                 360                 365             


Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met 
    370                 375                 380                 


Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly 
385                 390                 395                 400 


Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro 
                405                 410                 415     


Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg 
            420                 425                 430         


Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp 
        435                 440                 445             


Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys 
    450                 455                 460                 


His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn 
465                 470                 475                 480 


Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln 
                485                 490                 495     


Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp 
            500                 505                 510         


Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg 
        515                 520                 525             


Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr 
    530                 535                 540                 


Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser 
545                 550                 555                 560 


Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met 
                565                 570                 575     


Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu 
            580                 585                 590         


Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro 
        595                 600                 605             


Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu 
    610                 615                 620                 


Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr 
625                 630                 635                 640 


His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro 
                645                 650                 655     


Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg 
            660                 665                 670         


Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp 
        675                 680                 685             


Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu 
    690                 695                 700                 


His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser 
705                 710                 715                 720 


Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
                725                 730                 735     


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
            740                 745                 750         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        755                 760                 765             


Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val 
    770                 775                 780                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
785                 790                 795                 800 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                805                 810                 815     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            820                 825                 830         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        835                 840                 845             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    850                 855                 860                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
865                 870                 875                 880 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                885                 890                 895     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            900                 905                 910         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        915                 920                 925             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    930                 935                 940                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
945                 950                 955                 960 


Ser Leu Ser Leu Ser Pro Gly Lys 
                965             


<210> 122
<211> 966
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 122
Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala 
1               5                   10                  15      


Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg 
            20                  25                  30          


Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys 
        35                  40                  45              


Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro 
    50                  55                  60                  


Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro 
65                  70                  75                  80  


Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn 
                85                  90                  95      


Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr 
            100                 105                 110         


Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser 
        115                 120                 125             


Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe 
    130                 135                 140                 


Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg 
145                 150                 155                 160 


Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro 
                165                 170                 175     


His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser 
            180                 185                 190         


Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp 
        195                 200                 205             


Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His 
    210                 215                 220                 


Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly 
225                 230                 235                 240 


Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys 
                245                 250                 255     


Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp 
            260                 265                 270         


Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn 
        275                 280                 285             


Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His 
    290                 295                 300                 


Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro 
305                 310                 315                 320 


Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser 
                325                 330                 335     


Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe 
            340                 345                 350         


Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His 
        355                 360                 365             


Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met 
    370                 375                 380                 


Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly 
385                 390                 395                 400 


Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro 
                405                 410                 415     


Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg 
            420                 425                 430         


Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp 
        435                 440                 445             


Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys 
    450                 455                 460                 


His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn 
465                 470                 475                 480 


Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln 
                485                 490                 495     


Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp 
            500                 505                 510         


Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg 
        515                 520                 525             


Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr 
    530                 535                 540                 


Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser 
545                 550                 555                 560 


Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met 
                565                 570                 575     


Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu 
            580                 585                 590         


Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro 
        595                 600                 605             


Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu 
    610                 615                 620                 


Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr 
625                 630                 635                 640 


His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro 
                645                 650                 655     


Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg 
            660                 665                 670         


Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp 
        675                 680                 685             


Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu 
    690                 695                 700                 


His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser 
705                 710                 715                 720 


Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
                725                 730                 735     


Leu Ile Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            740                 745                 750         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        755                 760                 765             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    770                 775                 780                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
785                 790                 795                 800 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                805                 810                 815     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            820                 825                 830         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        835                 840                 845             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    850                 855                 860                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
865                 870                 875                 880 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                885                 890                 895     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            900                 905                 910         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        915                 920                 925             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    930                 935                 940                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
945                 950                 955                 960 


Ser Leu Ser Pro Gly Lys 
                965     


<210> 123
<211> 1076
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 123
Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg 
            20                  25                  30          


Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val 
        35                  40                  45              


Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro 
    50                  55                  60                  


Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu 
65                  70                  75                  80  


Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp 
                85                  90                  95      


Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val 
            100                 105                 110         


Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe 
        115                 120                 125             


Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu 
    130                 135                 140                 


Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys 
145                 150                 155                 160 


Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys 
                165                 170                 175     


Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser 
            180                 185                 190         


His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser 
        195                 200                 205             


Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly 
    210                 215                 220                 


Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr 
225                 230                 235                 240 


Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp 
                245                 250                 255     


Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu 
            260                 265                 270         


Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe 
        275                 280                 285             


Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly 
    290                 295                 300                 


Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Asn Met 
305                 310                 315                 320 


Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys 
                325                 330                 335     


Leu Asn Leu Ile Leu Val Ser Asp His Gly Met Glu Gln Gly Ser Cys 
            340                 345                 350         


Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile 
        355                 360                 365             


Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro 
    370                 375                 380                 


Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser 
385                 390                 395                 400 


Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu 
                405                 410                 415     


Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr 
            420                 425                 430         


Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg 
        435                 440                 445             


Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Ile Phe Ser Asn 
    450                 455                 460                 


Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile 
465                 470                 475                 480 


Glu Val Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp 
                485                 490                 495     


Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu 
            500                 505                 510         


Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu 
        515                 520                 525             


Val His Pro Leu Ile Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn 
    530                 535                 540                 


Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln 
545                 550                 555                 560 


Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Asn Ile Lys His Glu 
                565                 570                 575     


Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile 
            580                 585                 590         


Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile 
        595                 600                 605             


Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe 
    610                 615                 620                 


Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro 
625                 630                 635                 640 


Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val 
                645                 650                 655     


Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly 
            660                 665                 670         


Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln 
        675                 680                 685             


Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys 
    690                 695                 700                 


Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe 
705                 710                 715                 720 


Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln 
                725                 730                 735     


Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe 
            740                 745                 750         


Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His 
        755                 760                 765             


Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp 
    770                 775                 780                 


Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu 
785                 790                 795                 800 


Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile 
                805                 810                 815     


Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile 
            820                 825                 830         


Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Leu Ile 
        835                 840                 845             


Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    850                 855                 860                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
865                 870                 875                 880 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                885                 890                 895     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            900                 905                 910         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        915                 920                 925             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    930                 935                 940                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
945                 950                 955                 960 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                965                 970                 975     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            980                 985                 990         


Ser Leu Thr Cys Leu Val Lys Gly  Phe Tyr Pro Ser Asp  Ile Ala Val 
        995                 1000                 1005             


Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn Asn Tyr  Lys Thr Thr 
    1010                 1015                 1020             


Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe Phe Leu  Tyr Ser Lys 
    1025                 1030                 1035             


Leu Thr  Val Asp Lys Ser Arg  Trp Gln Gln Gly Asn  Val Phe Ser 
    1040                 1045                 1050             


Cys Ser  Val Met His Glu Ala  Leu His Asn His Tyr  Thr Gln Lys 
    1055                 1060                 1065             


Ser Leu  Ser Leu Ser Pro Gly  Lys 
    1070                 1075     


<210> 124
<211> 1076
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 124
Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg 
            20                  25                  30          


Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val 
        35                  40                  45              


Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro 
    50                  55                  60                  


Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu 
65                  70                  75                  80  


Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp 
                85                  90                  95      


Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val 
            100                 105                 110         


Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe 
        115                 120                 125             


Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu 
    130                 135                 140                 


Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys 
145                 150                 155                 160 


Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys 
                165                 170                 175     


Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser 
            180                 185                 190         


His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser 
        195                 200                 205             


Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly 
    210                 215                 220                 


Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr 
225                 230                 235                 240 


Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp 
                245                 250                 255     


Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu 
            260                 265                 270         


Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe 
        275                 280                 285             


Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly 
    290                 295                 300                 


Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met 
305                 310                 315                 320 


Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys 
                325                 330                 335     


Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys 
            340                 345                 350         


Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile 
        355                 360                 365             


Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro 
    370                 375                 380                 


Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser 
385                 390                 395                 400 


Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu 
                405                 410                 415     


Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr 
            420                 425                 430         


Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg 
        435                 440                 445             


Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn 
    450                 455                 460                 


Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile 
465                 470                 475                 480 


Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp 
                485                 490                 495     


Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu 
            500                 505                 510         


Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu 
        515                 520                 525             


Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn 
    530                 535                 540                 


Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln 
545                 550                 555                 560 


Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu 
                565                 570                 575     


Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Lys Asn Thr Ile 
            580                 585                 590         


Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile 
        595                 600                 605             


Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe 
    610                 615                 620                 


Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Ser 
625                 630                 635                 640 


Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val 
                645                 650                 655     


Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly 
            660                 665                 670         


Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln 
        675                 680                 685             


Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys 
    690                 695                 700                 


Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe 
705                 710                 715                 720 


Asp Phe Asp Tyr Asp Gly Arg Tyr Asp Ser Leu Glu Ile Leu Arg Gln 
                725                 730                 735     


Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe 
            740                 745                 750         


Phe Ile Val Leu Thr Ser Cys Lys Asp Ala Ser Gln Thr Pro Leu His 
        755                 760                 765             


Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp 
    770                 775                 780                 


Asn Ser Glu Ser Cys Val His Gly Lys His Glu Ser Ser Trp Val Glu 
785                 790                 795                 800 


Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile 
                805                 810                 815     


Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile 
            820                 825                 830         


Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Leu Ile 
        835                 840                 845             


Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    850                 855                 860                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
865                 870                 875                 880 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                885                 890                 895     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            900                 905                 910         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        915                 920                 925             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    930                 935                 940                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
945                 950                 955                 960 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                965                 970                 975     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            980                 985                 990         


Ser Leu Thr Cys Leu Val Lys Gly  Phe Tyr Pro Ser Asp  Ile Ala Val 
        995                 1000                 1005             


Glu Trp  Glu Ser Asn Gly Gln  Pro Glu Asn Asn Tyr  Lys Thr Thr 
    1010                 1015                 1020             


Pro Pro  Val Leu Asp Ser Asp  Gly Ser Phe Phe Leu  Tyr Ser Lys 
    1025                 1030                 1035             


Leu Thr  Val Asp Lys Ser Arg  Trp Gln Gln Gly Asn  Val Phe Ser 
    1040                 1045                 1050             


Cys Ser  Val Met His Glu Ala  Leu His Asn His Tyr  Thr Gln Lys 
    1055                 1060                 1065             


Ser Leu  Ser Leu Ser Pro Gly  Lys 
    1070                 1075     


<210> 125
<211> 1078
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 125
Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg 
            20                  25                  30          


Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val 
        35                  40                  45              


Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro 
    50                  55                  60                  


Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu 
65                  70                  75                  80  


Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp 
                85                  90                  95      


Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val 
            100                 105                 110         


Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe 
        115                 120                 125             


Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu 
    130                 135                 140                 


Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys 
145                 150                 155                 160 


Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys 
                165                 170                 175     


Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser 
            180                 185                 190         


His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser 
        195                 200                 205             


Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly 
    210                 215                 220                 


Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr 
225                 230                 235                 240 


Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp 
                245                 250                 255     


Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu 
            260                 265                 270         


Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe 
        275                 280                 285             


Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly 
    290                 295                 300                 


Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met 
305                 310                 315                 320 


Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys 
                325                 330                 335     


Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys 
            340                 345                 350         


Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile 
        355                 360                 365             


Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro 
    370                 375                 380                 


Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser 
385                 390                 395                 400 


Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu 
                405                 410                 415     


Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr 
            420                 425                 430         


Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg 
        435                 440                 445             


Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn 
    450                 455                 460                 


Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile 
465                 470                 475                 480 


Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp 
                485                 490                 495     


Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu 
            500                 505                 510         


Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu 
        515                 520                 525             


Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn 
    530                 535                 540                 


Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln 
545                 550                 555                 560 


Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu 
                565                 570                 575     


Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile 
            580                 585                 590         


Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile 
        595                 600                 605             


Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe 
    610                 615                 620                 


Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro 
625                 630                 635                 640 


Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val 
                645                 650                 655     


Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly 
            660                 665                 670         


Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln 
        675                 680                 685             


Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys 
    690                 695                 700                 


Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe 
705                 710                 715                 720 


Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln 
                725                 730                 735     


Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe 
            740                 745                 750         


Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His 
        755                 760                 765             


Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp 
    770                 775                 780                 


Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu 
785                 790                 795                 800 


Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile 
                805                 810                 815     


Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile 
            820                 825                 830         


Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Gly Gly 
        835                 840                 845             


Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    850                 855                 860                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
865                 870                 875                 880 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                885                 890                 895     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            900                 905                 910         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        915                 920                 925             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    930                 935                 940                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
945                 950                 955                 960 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                965                 970                 975     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            980                 985                 990         


Gln Val Ser Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 
        995                 1000                 1005             


Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
    1010                 1015                 1020             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    1025                 1030                 1035             


Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 
    1040                 1045                 1050             


Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 
    1055                 1060                 1065             


Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1070                 1075             


<210> 126
<211> 1078
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 126
Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg 
            20                  25                  30          


Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val 
        35                  40                  45              


Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro 
    50                  55                  60                  


Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu 
65                  70                  75                  80  


Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp 
                85                  90                  95      


Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val 
            100                 105                 110         


Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe 
        115                 120                 125             


Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu 
    130                 135                 140                 


Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys 
145                 150                 155                 160 


Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys 
                165                 170                 175     


Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser 
            180                 185                 190         


His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser 
        195                 200                 205             


Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly 
    210                 215                 220                 


Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr 
225                 230                 235                 240 


Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Thr Phe Pro Asp 
                245                 250                 255     


Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu 
            260                 265                 270         


Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe 
        275                 280                 285             


Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly 
    290                 295                 300                 


Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met 
305                 310                 315                 320 


Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys 
                325                 330                 335     


Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys 
            340                 345                 350         


Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile 
        355                 360                 365             


Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro 
    370                 375                 380                 


Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser 
385                 390                 395                 400 


Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu 
                405                 410                 415     


Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr 
            420                 425                 430         


Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg 
        435                 440                 445             


Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn 
    450                 455                 460                 


Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile 
465                 470                 475                 480 


Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp 
                485                 490                 495     


Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu 
            500                 505                 510         


Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu 
        515                 520                 525             


Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn 
    530                 535                 540                 


Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln 
545                 550                 555                 560 


Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu 
                565                 570                 575     


Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile 
            580                 585                 590         


Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile 
        595                 600                 605             


Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe 
    610                 615                 620                 


Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro 
625                 630                 635                 640 


Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val 
                645                 650                 655     


Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly 
            660                 665                 670         


Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln 
        675                 680                 685             


Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys 
    690                 695                 700                 


Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe 
705                 710                 715                 720 


Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln 
                725                 730                 735     


Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe 
            740                 745                 750         


Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His 
        755                 760                 765             


Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp 
    770                 775                 780                 


Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu 
785                 790                 795                 800 


Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile 
                805                 810                 815     


Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile 
            820                 825                 830         


Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Gly Gly 
        835                 840                 845             


Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    850                 855                 860                 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
865                 870                 875                 880 


Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp 
                885                 890                 895     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            900                 905                 910         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        915                 920                 925             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    930                 935                 940                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
945                 950                 955                 960 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                965                 970                 975     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
            980                 985                 990         


Gln Val Ser Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 
        995                 1000                 1005             


Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
    1010                 1015                 1020             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    1025                 1030                 1035             


Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 
    1040                 1045                 1050             


Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 
    1055                 1060                 1065             


Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1070                 1075             


<210> 127
<211> 989
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 127
Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Lys Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu 
            20                  25                  30          


Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser 
        35                  40                  45              


Leu Asp Gly Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu 
    50                  55                  60                  


Pro Val Ile Ser Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met 
65                  70                  75                  80  


Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val 
                85                  90                  95      


Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr 
            100                 105                 110         


Asp Pro Lys Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe 
        115                 120                 125             


Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr 
    130                 135                 140                 


Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu 
145                 150                 155                 160 


Ile Asn Gly Thr Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val 
                165                 170                 175     


Pro Phe Glu Glu Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro 
            180                 185                 190         


Lys Asp Glu Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp 
        195                 200                 205             


Ser Ser Gly His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala 
    210                 215                 220                 


Leu Gln Arg Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys 
225                 230                 235                 240 


Glu Leu Asn Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His 
                245                 250                 255     


Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr 
            260                 265                 270         


Leu Gly Asp Val Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg 
        275                 280                 285             


Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu 
    290                 295                 300                 


Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys 
305                 310                 315                 320 


Pro Tyr Leu Lys His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser 
                325                 330                 335     


Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu 
            340                 345                 350         


Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly 
        355                 360                 365             


Ser Asp Asn Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly 
    370                 375                 380                 


Pro Gly Phe Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu 
385                 390                 395                 400 


Val Tyr Asn Leu Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn 
                405                 410                 415     


Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr 
            420                 425                 430         


Thr Pro Lys His Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe 
        435                 440                 445             


Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile 
    450                 455                 460                 


Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu 
465                 470                 475                 480 


Glu Lys Ile Ile Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val 
                485                 490                 495     


Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met 
            500                 505                 510         


Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr 
        515                 520                 525             


Val Asp Arg Asn Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu 
    530                 535                 540                 


Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe 
545                 550                 555                 560 


Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln 
                565                 570                 575     


Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr 
            580                 585                 590         


Asn Ile Val Pro Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe 
        595                 600                 605             


His Asp Thr Leu Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn 
    610                 615                 620                 


Val Val Ser Gly Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp 
625                 630                 635                 640 


Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu 
                645                 650                 655     


Ile Leu Ile Pro Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp 
            660                 665                 670         


Thr Ser Gln Thr Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe 
        675                 680                 685             


Ile Leu Pro His Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys 
    690                 695                 700                 


His Asp Ser Ser Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg 
705                 710                 715                 720 


Ile Thr Asp Val Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg 
                725                 730                 735     


Lys Glu Pro Val Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr 
            740                 745                 750         


Phe Ser Gln Glu Asp Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys 
        755                 760                 765             


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
    770                 775                 780                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu 
785                 790                 795                 800 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                805                 810                 815     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            820                 825                 830         


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        835                 840                 845             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    850                 855                 860                 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
865                 870                 875                 880 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                885                 890                 895     


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            900                 905                 910         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        915                 920                 925             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    930                 935                 940                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
945                 950                 955                 960 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                965                 970                 975     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 985                 


<210> 128
<211> 987
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 128
Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Lys Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu 
            20                  25                  30          


Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser 
        35                  40                  45              


Leu Asp Gly Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu 
    50                  55                  60                  


Pro Val Ile Ser Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met 
65                  70                  75                  80  


Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val 
                85                  90                  95      


Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr 
            100                 105                 110         


Asp Pro Lys Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe 
        115                 120                 125             


Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr 
    130                 135                 140                 


Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu 
145                 150                 155                 160 


Ile Asn Gly Ile Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val 
                165                 170                 175     


Pro Phe Glu Glu Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro 
            180                 185                 190         


Lys Asp Glu Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp 
        195                 200                 205             


Ser Ser Gly His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala 
    210                 215                 220                 


Leu Gln Arg Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys 
225                 230                 235                 240 


Glu Leu Asn Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His 
                245                 250                 255     


Gly Met Glu Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr 
            260                 265                 270         


Leu Gly Asp Val Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg 
        275                 280                 285             


Leu Arg Pro Ser Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu 
    290                 295                 300                 


Gly Ile Ala Arg Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys 
305                 310                 315                 320 


Pro Tyr Leu Lys His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser 
                325                 330                 335     


Asp Arg Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu 
            340                 345                 350         


Ala Leu Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly 
        355                 360                 365             


Ser Asp Asn Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly 
    370                 375                 380                 


Pro Gly Phe Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu 
385                 390                 395                 400 


Val Tyr Asn Leu Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn 
                405                 410                 415     


Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr 
            420                 425                 430         


Thr Pro Lys His Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe 
        435                 440                 445             


Thr Arg Asn Pro Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile 
    450                 455                 460                 


Leu Pro Ile Glu Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu 
465                 470                 475                 480 


Glu Lys Ile Ile Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val 
                485                 490                 495     


Leu Gln Lys Glu Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met 
            500                 505                 510         


Ser Gly Tyr Ser Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr 
        515                 520                 525             


Val Asp Arg Asn Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu 
    530                 535                 540                 


Tyr Gln Asp Phe Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe 
545                 550                 555                 560 


Tyr Lys Asn Asn Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln 
                565                 570                 575     


Leu Asn Lys Asn Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr 
            580                 585                 590         


Asn Ile Val Pro Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe 
        595                 600                 605             


His Asp Thr Leu Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn 
    610                 615                 620                 


Val Val Ser Gly Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp 
625                 630                 635                 640 


Ser Leu Glu Asn Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu 
                645                 650                 655     


Ile Leu Ile Pro Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp 
            660                 665                 670         


Thr Ser Gln Thr Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe 
        675                 680                 685             


Ile Leu Pro His Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys 
    690                 695                 700                 


His Asp Ser Ser Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg 
705                 710                 715                 720 


Ile Thr Asp Val Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg 
                725                 730                 735     


Lys Glu Pro Val Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr 
            740                 745                 750         


Phe Ser Gln Glu Asp Leu Ile Asn Asp Lys Thr His Thr Cys Pro Pro 
        755                 760                 765             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    770                 775                 780                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
785                 790                 795                 800 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                805                 810                 815     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            820                 825                 830         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        835                 840                 845             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    850                 855                 860                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
865                 870                 875                 880 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                885                 890                 895     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            900                 905                 910         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        915                 920                 925             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    930                 935                 940                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
945                 950                 955                 960 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                965                 970                 975     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            980                 985         


<210> 129
<211> 19
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      N-terminal leader sequence"

<400> 129
Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala 
            


<210> 130
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 130
His His His His His His 
1               5       


<210> 131
<211> 10
<212> DNA
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Kozak sequence"

<400> 131
gccaccatgg                                                              10


<210> 132
<211> 6
<212> PRT
<213> Homo sapiens

<400> 132
Trp Val Glu Glu Pro Cys 
1               5       


<210> 133
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 133
Ser Arg Ala Lys Ser 
1               5   


<210> 134
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Any amino acid

<220>
<221> SITE
<222> (1)..(10)
<223> /note="This sequence may encompass 1-5 'Xaa Pro'
      repeating units"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 134
Xaa Pro Xaa Pro Xaa Pro Xaa Pro Xaa Pro 
1               5                   10  


