                         SEQUENCE LISTING

<110>  ZOETIS SERVICES LLC
       LISA, BERGERON
       HENRY, CAMPOS
       BAMMERT, GARY
       LIGHTLE, SANDRA
       STRIETZEL, CATHERINE
 
<120>  ANTI-TGFB MONOCLONAL ANTIBODIES AND THERAPEUTIC USES THEREOF

<130>  ZP000348

<160>  293   

<170>  PatentIn version 3.5

<210>  1
<211>  351
<212>  DNA
<213>  Mus musculus

<400>  1
caggtccagc tacagcagtc tggggctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttctggcta cgcattcagt agctcctgga tgaactgggt gaagcagagg      120

cctggaaagg gtcttgagtg gattggacag atttatcctg gagatggtga tactaactac      180

aatggaaagt tcaagggtaa agccacactg actgcagaca aatcctccag cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgcggtct atttctgtgc aagacactat      300

gatggttcca ctgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  2
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  2

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  3
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  3
gacatccaga tgactcagtc tccagcctcc ctatctgtat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga aaatatttac agtaatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctatgct gcaacaaact tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag tattccctca agatcaatag tctgcagtct      240

gaagattttg ggagttatta ctgtcaacat ttttggggta ctccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  4
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  5
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  5

Ser Ser Trp Met Asn 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  7

Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr 
1               5                   10  


<210>  8
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  8

Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  9

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  10

Gln His Phe Trp Gly Thr Pro Tyr Thr 
1               5                   


<210>  11
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Can04H09-VH1

<400>  11
gaggtgcagc tggtgcagtc cggagctgag gtgaagaagc caggagcttc cgtgaaggtg       60

agctgcaaga catctggcta caccttcatc tccagctgga tgaactgggt gagacaggct      120

ccaggagctg gcctggactg gatgggccag atctaccctg gcgacggcga tacaaactat      180

aatggcaagt ttaagggaag ggtgaccctg acagctgaca ccagcacatc taccgcttac      240

atggagctgt cttccctgag ggccggcgat atcgccgtgt actattgtgc ccggcactat      300

gacggctcca ccgattactg gggccagggc acactggtga ccgtctcgag c               351


<210>  12
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can04H09-VH1

<400>  12

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  13
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Can04H09-VH2

<400>  13
gaggtgcagc tggtgcagtc cgccgctgag gtgaagaagc caggcgcctc tgtgaaggtg       60

tcctgcaaga cctccggcta cagcttcaca tccagctgga tgaactgggt gcagcaggct      120

ccaggcaagg gcctggactg gatgggacag atctaccctg gcgacggcga taccaactat      180

aatggcaagt ttaagggcag ggtgaccctg acagccgaca agagcacctc tacagcttac      240

atggagctgt cttccctgag gagcgaggat gccgccgtgt actattgtgc ccggcactat      300

gacggctcta cagattactg gggccagggc accctggtga cagtctcgag c               351


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can04H09-VH2

<400>  14

Glu Val Gln Leu Val Gln Ser Ala Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Can04H09-VH3

<400>  15
gaggtgcagc tggtgcagtc cgccgctgag gtgaagaagc caggcgcctc cgtgaaggtg       60

agctgcaaga catctggcta caccttcaca tccagctgga tgaactgggt gcagcaggct      120

ccaggagctg gcctggactg gatgggccag atctaccctg gcgacggcga taccaactat      180

aatggcaagt ttaagggcag ggtgaccctg acagccgaca ccagcacatc taccgcttac      240

atggagctgt cttccctgag ggccgaggat acagccgtgt actattgtgc tcggcactat      300

gacggctcca ccgattactg gggccagggc acactggtga ccgtctcgag c               351


<210>  16
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can04H09-VH3

<400>  16

Glu Val Gln Leu Val Gln Ser Ala Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Gln Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  17
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Can04H09-VK1

<400>  17
gacatcgtga tgacccagaa cccactgtcc ctgagcgtgt ctcccggcga gacagcctcc       60

atcagctgca gggcttctga gaacatctac tccaatctgg cctggttcag acagaagcca      120

ggacagagcc ctcagcgcct gatctatgcc gctaccaatc tggctgacgg cgtgcctgat      180

agattctctg gatccggaag cggcaccgac ttcaccctga ggatctctcg ggtggaggcc      240

gacgatacag gcgtgtacta ttgtcagcac ttctggggca ccccatacac atttggccag      300

ggtacc                                                                 306


<210>  18
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can04H09-VK1

<400>  18

Asp Ile Val Met Thr Gln Asn Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Arg Gln Lys Pro Gly Gln Ser Pro Gln Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val Glu Ala 
65                  70                  75                  80  


Asp Asp Thr Gly Val Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys 
            100             


<210>  19
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Can04H09-VK2

<400>  19
gacaccgtgc tgacccagac acccccttcc ctgagcctgt ctccaggaga gccagcttcc       60

atcagctgca gagcttctga gaacatctac tccaatctgg cctggttcag gcagaagcct      120

ggacagtccc cacagcggct gatcaacgcc gctaccaatc tggctgacgg cgtgcccgac      180

aggttctccg gatccggaag cggcacagac ttctccctga agatcaactc tgtggccgct      240

gacgatgccg gcatctacta ttgtcagcac ttctggggca ccccttatac cttctcccag      300

ggtacc                                                                 306


<210>  20
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can04H09-VK2

<400>  20

Asp Thr Val Leu Thr Gln Thr Pro Pro Ser Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Phe Arg Gln Lys Pro Gly Gln Ser Pro Gln Arg Leu Ile 
        35                  40                  45              


Asn Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Lys Ile Asn Ser Val Ala Ala 
65                  70                  75                  80  


Asp Asp Ala Gly Ile Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Ser Gln Gly Thr Lys 
            100             


<210>  21
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Can04H09-VK3

<400>  21
gagatcgtga tgacccagtc ccctgcttct ctgtccctga gccaggagga gaaggtgacc       60

atcacatgca gggcctctga gaacatctac tccaatctgg cttggtatca gcagaagccc      120

ggccaggccc ctaagctgct gatctacgcc gctacaaacc tggctgacgg cgtgccaagc      180

cggttctctg gatccggaag cggcaccgac ttctctttta caatctccag cctggagcca      240

gaggatgtgg ccgtgtacta ttgtcagcac ttctggggca ccccctatac atttggccag      300

ggtacc                                                                 306


<210>  22
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can04H09-VK3

<400>  22

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys 
            100             


<210>  23
<211>  306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Can04H09-VK4

<400>  23
gagatcgtga tgacccagtc ccctgcttct ctgtccctga gccagggcga gaaggtgacc       60

atcacatgca gggcctctga gaacatctac tccaatctgg cttggtatca gcagcggccc      120

ggacaggctc ctaagctgct gatctacgcc gctacaaacc tggctgacgg cgtgccaagc      180

aggttctctg gatccggaag cggcaccgac ttttctctga caatctccag cctggagcca      240

gaggatgtgg ccgtgtacta ttgtcagcac ttctggggca ccccctatac atttggccag      300

ggtacc                                                                 306


<210>  24
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can04H09-VK4

<400>  24

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys 
            100             


<210>  25
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fel04H09-H636

<400>  25
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggtgctgaag ttcgcagacc aggcgccagc      120

gtgaagattt tctgtaaagc cagcggctac agcttcacca gcagctggat gaactggctg      180

agacaggccc ctgctcaggg ctttgagtgg atgggacaaa tctaccctgg cgacggcgac      240

accaactaca acggcaagtt taagggcaga ctgaccctga ccgccgacac cagcacagat      300

acagcctaca tggaactgag cagcctgaga agcgccgata ccgccgtgta ctactgcgcc      360

agacactacg atggcagcac cgattattgg ggccacggca ccattgtgac agtctcgagc      420


<210>  26
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fel04H09-H636

<400>  26

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Leu Arg Gln Ala Pro Ala Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr Trp Gly His Gly Thr Ile 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  27
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fel04H09-H1-2

<400>  27
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggcgccgaag tgcggaaacc tgaggccagc      120

gtgaagattt tctgcaaggc cagcggctac agcttcacca gcagctggat gaactgggtc      180

cgacaggctc ctgctcaggg ctttgagtgg atgggccaaa tctatcctgg cgacggcgac      240

accaactaca acggcaagtt taagggcaga ctgaccctga ccgccgacac cagcacaaac      300

acagcctaca tggaactgag cagcctgaga agcaccgaca tggccgtgta ctactgcgcc      360

agacactacg acggcagcac agattattgg ggccagggcg ctctggtcac agtctcgagc      420


<210>  28
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fel04H09-H1-2

<400>  28

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Glu Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Ala Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Thr Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr Trp Gly Gln Gly Ala Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  29
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fel04H09-H618

<400>  29
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggcgccgaag ttcggaaacc aggcgccagc      120

gtgaagattt tctgcaaggc cagcggctac agcttcacca gcagctggat gaactggctg      180

agacaggccc ctgaacaggg cctcgaatgg atgggacaaa tctaccctgg cgacggcgac      240

accaactaca acggcaagtt taagggcaga ctgaccctga ccgccgacac cagcacaaac      300

acagcctaca tggaactgag cagcctgaga agcgccgata ccgccatgta ctactgcgcc      360

agacactacg acggcagcac agattattgg ggccagggcg ctctggtcac agtctcgagc      420


<210>  30
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fel04H09-H618

<400>  30

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Ser 
            20                  25                  30          


Trp Met Asn Trp Leu Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Gly Ser Thr Asp Tyr Trp Gly Gln Gly Ala Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  31
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fel04H09-K4-1

<400>  31
aagcttggcc accatgagtg ttcctaccca agtgctggga ctgctgctgc tgtggctgac       60

agatgctcgg tgcgccatca caatgacaca gagccctgga tctctggccg gctctcctgg      120

acagcaagtg accatgaatt gccgggccag cgagaacatc tacagcaacc tggcctggta      180

tcagcagaag cccggacagc accctaagct gctgatctac gccgccacaa atctggccga      240

tggcgtgcca gatagatttt ctggcagcgg ctctggcacc gacttcaccc tgacaattag      300

caacctgcag gccgaggacg tggccagcta ctactgtcag cacttttggg gcacccctta      360

cacctttggc ggaggtacc                                                   379


<210>  32
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fel04H09-K4-1

<400>  32

Ala Ile Thr Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Pro Gly 
1               5                   10                  15      


Gln Gln Val Thr Met Asn Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln His Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Ser Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr 
            100         


<210>  33
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fel04H09-K36

<400>  33
aagcttggcc accatgagtg ttcctaccca agtgctggga ctgctgctgc tgtggctgac       60

agatgctcgg tgcgacatcg tgatgaccca gacacctctg agcctgcctg ttacacctgg      120

cgagcctgcc agcatctctt gcagagccag cgagaacatc tacagcaacc tggcctggta      180

tctgcagaag cccggacagt ctcccagact gctgatctac gccgccacaa atctggccga      240

tggcgtgcca agcagatttt ctggcagcgg ctctggcacc gacttcaccc tgagaattag      300

cagcgtggaa gccgacgacg tgggcgtgta ctactgtcag cacttttggg gcacccctta      360

caccttcgga cagggtacc                                                   379


<210>  34
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fel04H09-K36

<400>  34

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Ser Val Glu Ala 
65                  70                  75                  80  


Asp Asp Val Gly Val Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr 
            100         


<210>  35
<211>  379
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fel04H09-K1-1

<400>  35
aagcttggcc accatgagtg ttcctaccca agtgctggga ctgctgctgc tgtggctgac       60

agatgctcgg tgcgagatcc agatgacaca gagccctagc agcctgtctg cctctcctgg      120

cgatagagtg accatcacct gtcgggccag cgagaacatc tacagcaacc tggcctggta      180

tcagcagaaa cccggcaagg tgcccaagct gctgatctac gctgccacaa atctggccga      240

tggcgtgcca agcagatttt ctggaagcgg cagcggcacc gacttcaccc tgaccatatc      300

tagcctggaa cctgaggacg ccgccaccta ctactgtcag cacttttggg gcacccctta      360

cacctttggc ggcggtacc                                                   379


<210>  36
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fel04H09-K1-1

<400>  36

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Phe Trp Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr 
            100         


<210>  37
<211>  369
<212>  DNA
<213>  Mus musculus

<400>  37
gaggtccagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg agctggagtg ggtggcagtt atatcatatg atggaagtat taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gcgaactggt      300

gaatatagtg gctacgatac ggacccccag tactcctggg ggcaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  38
<211>  123
<212>  PRT
<213>  Mus musculus

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  39
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  39
gaaattgtgc tgactcagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattgga gatgatttgg gctggtatca gcagaagcca      120

gggaaagccc ctatcctcct gatctatggt acatccactt tacaaagtgg ggtcccgtca      180

aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcaacag cctgcagcct      240

gaagattttg caacttatta ctgtctacaa gattccaatt acccgctcac tttcggcgga      300

ggtaccaagc tcgagatcaa a                                                321


<210>  40
<211>  103
<212>  PRT
<213>  Mus musculus

<400>  40

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Asp Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Ile Leu Leu Ile 
        35                  40                  45              


Tyr Gly Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  41
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  41

Phe Ser Ser Tyr Gly Met His 
1               5           


<210>  42
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  42

Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr 
1               5                   10      


<210>  43
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  43

Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Ser 
1               5                   10                  


<210>  44
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  44

Arg Ala Ser Gln Gly Ile Gly Asp Asp Leu Gly 
1               5                   10      


<210>  45
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  45

Gly Thr Ser Thr Leu Gln Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  46

Leu Gln Asp Ser Asn Tyr Pro Leu Thr 
1               5                   


<210>  47
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can SL501-VH1

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Thr Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  48
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can SL501-VH2

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  49
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can SL501-VK1

<400>  49

Glu Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Leu Ser Gln Glu 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Asp Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Asp Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys 
            100             


<210>  50
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Can SL501-VK2

<400>  50
gagatcgtga tgacccagag ccctggctct ctggccggat ctgctggcga gagcgtgtcc       60

atcaactgca gagcctctca gggcatcggc gacgacctgg gctggtatca gcagaagccc      120

ggcgagaggc ccaagctgct gatctacggc accagcaccc tgcagagcgg agtgcctgcc      180

agattttcca gcagcggcag cggcaccgac ttcaccctga ccatcaacaa cctgcaggcc      240

gaggacgtgg gcgactacta ctgtctgcaa gacagcaact accccctgac ctttggcgcc      300

ggtaccaag                                                              309


<210>  51
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can SL501-VK2

<400>  51

Glu Ile Val Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Ala Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Asn Cys Arg Ala Ser Gln Gly Ile Gly Asp Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Glu Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Thr Ser Thr Leu Gln Ser Gly Val Pro Ala Arg Phe Ser Ser 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Asn Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Asp Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys 
            100             


<210>  52
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Can SL501-VK-Hybrid

<400>  52
gagatcgtgc tgacccagtc cccttccagc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacctgtc gggcctctca gggcatcggc gacgatctgg gatggtatca gcagaagcca      120

ggccaggccc ccaagctgct gatctacggc acctccacac tgcagtccgg cgtgccctct      180

agattctccg gctctggctc cggcaccgac ttcagcttca ccatctccag cctggaaccc      240

gaggacgtgg ccgtgtacta ctgtctgcaa gactccaact accccctgac cttcggcgga      300

ggtaccaag                                                              309


<210>  53
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can SL501-VK-Hybrid

<400>  53

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Asp Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Phe Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Asp Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  54
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Can SL501-VH3

<400>  54
gaagtgcagc tggtggaatc tggcggcgac ctcgtgaagc ctggcggctc tctgagactg       60

tcctgtgtgg cctccggctt caccttctcc agctacggca tgcactgggt gcgacaggcc      120

cctggaaaag gcctgcagtg ggtggccgtg atctcctacg acggctccat caagtactac      180

gccgacgccg tgaagggccg gttcaccatc agcagagaca acgccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tagaaccggc      300

gagtactccg gctacgatac cgacccccag tactcttggg gccagggcac cacagtgacc      360

gtctcgagc                                                              369


<210>  55
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Can SL501-VH3

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Gln Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  56
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SL501-VH3-FW2

<400>  56
gaagtgcagc tggtggaatc tggcggcgac ctcgtgaagc ctggcggctc tctgagactg       60

tcctgtgtgg cctccggctt caccttctcc agctacggca tgcactgggt gcgacaggcc      120

cctggaaaag agctggagtg ggtggccgtg atctcctacg acggctccat caagtactac      180

gccgacgccg tgaagggccg gttcaccatc agcagagaca acgccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tagaaccggc      300

gagtactccg gctacgatac cgacccccag tactcttggg gccagggcac cacagtgacc      360

gtctcgagc                                                              369


<210>  57
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SL501-VH3-FW2

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  58
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fel SL501-VH3-9

<400>  58
gacgtacaac tcgtggaaag cggtggggat ctcgtcaaac cagggggttc cctccgtctc       60

acttgcgtag catcaggttt cactttctcc agttacggaa tgcattgggt gaggcaggcc      120

cccggcaagg aattggaatg ggtagcagta atatcctacg atgggtccat caagtactac      180

gcagatgcag tcaagggacg gttcactatc agtcgtgaca atgccaaaaa caccctgtac      240

ttgcagatga acagcctcaa gactgaggat accgcaactt attattgcgc tcgtacagga      300

gaatacagtg ggtacgatac tgaccctcaa tactcatggg gacaaggcac aacagtaaca      360

gtctcgagc                                                              369


<210>  59
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fel SL501-VH3-9

<400>  59

Asp Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  60
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fel SL501-VK1-1

<400>  60
gaaattcaga tgacccagag tccttccagt cttagtgcct cacccggaga tagggtcacc       60

attacttgta gggcaagcca ggggatcgga gacgatcttg ggtggtatca gcaaaaacca      120

ggtaaggttc caaaactttt gatctatggt actagcaccc tccaatctgg ggtgccaagt      180

cggttctccg gtagcggctc agggactgac ttcactttga caatttcaag tctggaacca      240

gaagacgcag ctacatatta ttgccttcag gattccaatt acccacttac cttcggaggg      300

ggtaccaaa                                                              309


<210>  61
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fel SL501-VK1-1

<400>  61

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Asp Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gln Asp Ser Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  62
<211>  345
<212>  DNA
<213>  Mus musculus

<400>  62
caggtgcagc tggaggagtc aggacctgag ctggtgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta tatcttcatc acctactgga tgaactgggt gaagcagagg      120

cctggacagg gccttgagtg gattggacag atttttcctg caagtggtag tactaactac      180

aatgagatgt tcgagggcaa ggccacattg actgtagaca catcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagaggagat      300

ggtaactacg ccctggatgc tatggactac tggggtcaag gaacc                      345


<210>  63
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  63

Leu Pro Gln Val Gln Leu Glu Glu Ser Gly Pro Glu Leu Val Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile 
            20                  25                  30          


Thr Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu 
    50                  55                  60                  


Met Phe Glu Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr 
        115         


<210>  64
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  64
gacattgtgc tgacacagac tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac      120

cagcagaaat caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattgat      240

cctgtggagg ctgatgatgc tgcaacctat tactgtcagc aaaataatga ggatccgctc      300

acgttcggtg ctgggaccaa g                                                321


<210>  65
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  65

Asp Ile Val Leu Thr Gln Thr Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Ser Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            100                 105         


<210>  66
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  66

Gly Tyr Ile Phe Ile Thr Tyr 
1               5           


<210>  67
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  67

Phe Pro Ala Ser Gly Ser 
1               5       


<210>  68
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  68

Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr 
1               5                   10          


<210>  69
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  69

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  70
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  70

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  71
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  71

Gln Gln Asn Asn Glu Asp Pro Leu Thr 
1               5                   


<210>  72
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VH1

<400>  72
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatc acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag caagcggatc taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggcgac      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gaca            354


<210>  73
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VH1

<400>  73

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr 
        115             


<210>  74
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VH2

<400>  74
gaagtgcagc tggtgcagtc tgccgcagaa gttaagaagc ccggtgccag cgtgaaagtc       60

agctgcaaga catctggcta ttcattcacc acctactgga tgaactgggt gcaacaggct      120

cccggaaaag gcctcgattg gatgggtcag atctttcccg cttctggctc cacaaattat      180

aatgaaatgt tcgaagggag agtgaccctg accgttgaca ctagtactag taccgcctac      240

atggagctca gcagcctgcg cgccgaggac gctgccgtgt actattgcgc tcgcggtgat      300

ggtaactacg ctcttgatgc aatggattat tggggtcagg gaaccttggt cacc            354


<210>  75
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VH2

<400>  75

Glu Val Gln Leu Val Gln Ser Ala Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr 
        115             


<210>  76
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VH3

<400>  76
gaggtccagc tcgtccagtc tggtgcagaa gtcaaaaagc ctggtgcctc cgtgaaggtt       60

tcttgtaaga cttctggcta cacatttatc acctactgga tgaattgggt gagacaggcc      120

cccggggccg gccttgactg gatgggccaa atctttcctg cctccgggag tacaaactac      180

aacgaaatgt ttgaaggtag agtgacactg accgcagata cctccacatc caccgcatac      240

atggagctta gctctcttag ggcaggggat attgccgttt actactgtgc tcgcggtgat      300

gggaactacg cactggacgc catggactac tgggggcagg gaaccttggt caca            354


<210>  77
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VH3

<400>  77

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr 
        115             


<210>  78
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VK1

<400>  78
gacatcgtaa tgactcaaac ccccctgagt ctttctgtct cccctggcga gccagcatct       60

atttcttgcc gcgcatccga gtcagtggat tcttatggaa atagtttcat gcattggttc      120

caacagaagc ccgggcagtc cccccaacgc ctcatatacc tggcttcaaa tcttgagtcc      180

ggggttcccg acaggtttag cgggtccggg tcagggacag acttcaccct caggatttca      240

cgagtcgaag cagatgatgc cggtgtgtat tattgtcaac agaataacga ggaccctctg      300

acttttggcc ag                                                          312


<210>  79
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VK1

<400>  79

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Arg Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gln 
            100                 


<210>  80
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VK2

<400>  80
gacatcgtga tgacccaaac tccattgtcc ctgtccgtgt cccccggaga gactgctagc       60

atatcctgtc gcgccagtga gtctgtggac tcatacggca acagcttcat gcattggttt      120

cggcaaaagc ctggccagtc ccctcagggg ctgatttatc ttgcttccaa ccttgaatct      180

ggcgtccctg atagattctc tggaagcggg tccggtactg actttacact caggatctca      240

cgggtggaag ctgatgacgc aggggtttac tattgccagc agaacaacga ggaccctctg      300

acatttggac aa                                                          312


<210>  81
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VK2

<400>  81

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Arg Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Gly Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gln 
            100                 


<210>  82
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VK3

<400>  82
gatatcgtga tgacacaaac tccactctca ttgagcgtaa gccccggaga gacagccagc       60

atatcatgcc gggctagtga aagcgtggat tcttatggga actcatttat gcactggttc      120

cggcagaagc caggacagag tccccagaga ctcatctacc tggcaagtaa cctcgaatct      180

ggtgtgccag accgttttag tggtagcggt agcgggaccg acttcacact gagaatcagc      240

cgtgtggaag ctgacgatac tggggtttat tactgtcagc agaacaacga ggaccctctg      300

accttcggcc aa                                                          312


<210>  83
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VK3

<400>  83

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Arg Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Arg Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Thr Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gln 
            100                 


<210>  84
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VK4

<400>  84
gatattgtga tgacacagac tccaccctcc ctttctgtca gccctcggga gaccgcctcc       60

attagctgtc gcgccagtga gtccgtcgat tcctacggaa atagcttcat gcactggtat      120

ctgcagaaac caggtcagtc tcctcaattg ctgatctacc tggcttctaa cctggaaagc      180

ggtgtgtcag ataggttttc cggaagtggt agcggaactg actttaccct gcgtatttcc      240

cgagtggaag ccaatgacac tggtgtttac tactgtcagc agaataacga agaccccctg      300

acctttggcc ag                                                          312


<210>  85
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VK4

<400>  85

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Ser Val Ser Pro Arg 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Ser Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asn Asp Thr Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gln 
            100                 


<210>  86
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VK5

<400>  86
gatattgtca tgactcagac cccactgagt ttgagtgtca gtcctggaga gcctgccagc       60

ataagttgcc gcgcatcaga gagtgtggat tcttacggca attctttcat gcattggttc      120

cagcagaagc ccggccagag cccacagagg ctgatttact tggcttcaaa cttggaaagt      180

ggagttcctg accggtttag cggctctggg tccggcaccg actttacact ccgtatcagt      240

cgcgtggaag ccgatgacgc tggggtctat tactgtcagc agaacaatga ggacccactg      300

acctttggtc ag                                                          312


<210>  87
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CanHcLb-VK5

<400>  87

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Arg Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Ala Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gln 
            100                 


<210>  88
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  canHcLb-VK4-S71P

<400>  88
gatattgtga tgacacagac tccaccctcc ctttctgtca gccctcggga gaccgcctcc       60

attagctgtc gcgccagtga gtccgtcgat tcctacggaa atagcttcat gcactggtat      120

ctgcagaaac caggtcagcc tcctcaattg ctgatctacc tggcttctaa cctggaaagc      180

ggtgtgtcag ataggttttc cggaagtggt agcggaactg actttaccct gcgtatttcc      240

cgagtggaag ccaatgacac tggtgtttac tactgtcagc agaataacga agaccccctg      300

acctttggcc ag                                                          312


<210>  89
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canHcLb-VK4-S71P

<400>  89

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Ser Val Ser Pro Arg 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Ser Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asn Asp Thr Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe 
            100         


<210>  90
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  canHcLb-VK4-Q73K

<400>  90
gatattgtga tgacacagac tccaccctcc ctttctgtca gccctcggga gaccgcctcc       60

attagctgtc gcgccagtga gtccgtcgat tcctacggaa atagcttcat gcactggtat      120

ctgcagaaac caggtcagtc tcctaaattg ctgatctacc tggcttctaa cctggaaagc      180

ggtgtgtcag ataggttttc cggaagtggt agcggaactg actttaccct gcgtatttcc      240

cgagtggaag ccaatgacac tggtgtttac tactgtcagc agaataacga agaccccctg      300

acctttggcc ag                                                          312


<210>  91
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canHcLb-VK4-Q73K

<400>  91

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Ser Val Ser Pro Arg 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Ser Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asn Asp Thr Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gln 
            100                 


<210>  92
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  canHcLb-VK4-S71P-Q73K

<400>  92
gatattgtga tgacacagac tccaccctcc ctttctgtca gccctcggga gaccgcctcc       60

attagctgtc gcgccagtga gtccgtcgat tcctacggaa atagcttcat gcactggtat      120

ctgcagaaac caggtcagcc tcctaaattg ctgatctacc tggcttctaa cctggaaagc      180

ggtgtgtcag ataggttttc cggaagtggt agcggaactg actttaccct gcgtatttcc      240

cgagtggaag ccaatgacac tggtgtttac tactgtcagc agaataacga agaccccctg      300

acctttggcc ag                                                          312


<210>  93
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  canHcLb-VK4-S71P-Q73K

<400>  93

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Ser Val Ser Pro Arg 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Ser Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asn Asp Thr Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gln 
            100                 


<210>  94
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H636

<400>  94
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggtgctgaag ttcgcagacc aggcgccagc      120

gtgaagattt tctgtaaagc cagcggctac atcttcatca cctactacat gcactggctg      180

cggcaggccc ctgctcaggg atttgagtgg atgggcagca tctttcctgc cagcggcagc      240

acaagctacg cccagaaatt tcaggggaga ctgaccctga ccgccgacac aagcacagac      300

acagcctaca tggaactgag cagcctgaga agcgccgaca ccgccgtgta ttattgtgcc      360

agaggcgacg gcaactacgc cctggatgct atggattatt ggggccacgg caccatcgtg      420

acagtctcga gc                                                          432


<210>  95
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H636

<400>  95

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Ala Pro Ala Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Phe Pro Ala Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


His Gly Thr Ile Val Thr Val Ser Ser 
        115                 120     


<210>  96
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1

<400>  96
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggcgctgaag ttcggactcc tggcgcctcc      120

gtgaagattt tctgtaaagc cagcggctac atcttcatca cctactacat gcactgggtc      180

cgacagagcc ctgctcaggg acttgagtgg atgggcagca tctttcctgc cagcggcagc      240

acaagctacg cccagaaatt tcaggggaga ctgaccctga ccgccgacac aagcacaaac      300

accgcctaca tggaactgag cagcctgaga agcgccgaca ccgccatgta ttattgtgcc      360

agaggcgacg gcaactacgc cctggatgct atggattatt ggggccaggg caccagcgtg      420

acagtctcga gc                                                          432


<210>  97
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1

<400>  97

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Thr Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ser Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Phe Pro Ala Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  98
<211>  391
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-K1-1

<400>  98
aagcttggcc accatgagtg ttcctaccca agtgctggga ctgctgctgc tgtggctgac       60

agatgctcgg tgcgagatcc agatgacaca gagccctagc agcctgtctg cctctcctgg      120

cgatagagtg accatcacct gtagagccag cgagtccgtg gacagctacg gcaatagctt      180

catgcactgg tatcagcaga aacccggcaa ggtgcccaag ctgctgatct acctggccag      240

caatctggaa agcggcgtgc caagcagatt ttctggcagc ggctctggca ccgacttcac      300

cctgaccatt tctagcctgg aacctgagga cgccgccacc tactactgcc agcagaacaa      360

tgaggaccct ctgacctttg gcgccggtac c                                     391


<210>  99
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-K1-1

<400>  99

Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr 
            100                 105     


<210>  100
<211>  391
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-K36

<400>  100
aagcttggcc accatgagtg ttcctaccca agtgctggga ctgctgctgc tgtggctgac       60

agatgctcgg tgcgacatcg tgatgaccca gacacctctg agcctgcctg ttacacctgg      120

cgagcctgcc agcatctctt gtagagccag cgagtctgtg gacagctacg gcaacagctt      180

catgcactgg tatctgcaga agcccggaca gagccccaga ctgctgatct acctggccag      240

caatctggaa agcggcgtgc caagcagatt ttctggcagc ggctctggca ccgacttcac      300

cctgagaatt agcagcgtgg aagccgacga cgtgggcgtg tactactgcc agcagaacaa      360

tgaggaccct ctgacctttg gcgccggtac c                                     391


<210>  101
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-K36

<400>  101

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Ser Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr 
            100                 105     


<210>  102
<211>  391
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-K4-1

<400>  102
aagcttggcc accatgagtg ttcctaccca agtgctggga ctgctgctgc tgtggctgac       60

agatgctcgg tgcgccatca caatgacaca gagccctgga tctctggccg gctctcctgg      120

acagcaagtg accatgaatt gcagagccag cgagagcgtg gacagctacg gcaatagctt      180

catgcactgg tatcagcaga agcccggaca gcaccccaag ctgctgatct acctggccag      240

caatctggaa agcggcgtgc cagatagatt ttctggcagc ggctctggca ccgacttcac      300

cctgacaatt agcaacctgc aggccgagga cgtggccagc tactactgtc agcagaacaa      360

cgaggaccct ctgacctttg gagccggtac c                                     391


<210>  103
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb- K4-1

<400>  103

Ala Ile Thr Met Thr Gln Ser Pro Gly Ser Leu Ala Gly Ser Pro Gly 
1               5                   10                  15      


Gln Gln Val Thr Met Asn Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln His Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Asn Leu Gln Ala Glu Asp Val Ala Ser Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr 
            100                 105     


<210>  104
<211>  391
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb- K2D-2

<400>  104
aagcttggcc accatgagtg ttcctaccca agtgctggga ctgctgctgc tgtggctgac       60

agatgctcgg tgcgacgtgg tcatgacaca gacacctctg agcctgcctg tgacacctgg      120

cgaacctgcc tctatctctt gtagagccag cgagtccgtg gacagctacg gcaatagctt      180

catgcactgg tatctgcaga agcccggaca gagccccaga aggctgatct acctggccag      240

caatctggaa agcggcgtgc cagatagatt ttctggcagc ggctctggca ccgacttcac      300

cctgagaatc agcagagtgg aagccgacga cgtgggcgtg tactactgcc agcagaacaa      360

tgaggaccct ctgacctttg gcgccggtac c                                     391


<210>  105
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb- K2D-2

<400>  105

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Arg Arg Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr 
            100                 105     


<210>  106
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H618s

<400>  106
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggcgccgaag ttcggaaacc aggcgccagc      120

gtgaagattt tctgcaaggc cagcggctac accttcatca cctactacat gcactggctg      180

cggcaggccc ctgaacaagg acttgagtgg atgggcagaa tcttccctgc cagcggcagc      240

acaagctacg cccagaaatt tcaggggaga ctgaccctga ccgccgacac aagcacaaac      300

accgcctaca tggaactgag cagcctgaga agcgccgaca ccgccatgta ttattgtgcc      360

agaggcgacg gcaactacgc cctggatgct atggattatt ggggccaggg cgctctggtc      420

acagtctcga gc                                                          432


<210>  107
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H618s

<400>  107

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Ala Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120     


<210>  108
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H636x

<400>  108
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggtgctgaag ttcgcagacc aggcgccagc      120

gtgaagattt tctgtaaagc cagcggctac atcttcatca cctactacat gcactggctg      180

cggcaggccc ctgctcaggg atttgaatgg atgggccaga ttttccctgc cagcggcagc      240

accaactaca acgagatgtt tgagggcaga ctgaccctga ccgccgatac cagcacagac      300

acagcctaca tggaactgag cagcctgaga agcgccgaca ccgccgtgta ttattgtgcc      360

agaggcgacg gcaactacgc cctggatgct atggattatt ggggccacgg caccatcgtg      420

acagtctcga gc                                                          432


<210>  109
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H636x

<400>  109

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Ala Pro Ala Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


His Gly Thr Ile Val Thr Val Ser Ser 
        115                 120     


<210>  110
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1x

<400>  110
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggcgctgaag ttcggactcc tggcgcctcc      120

gtgaagattt tctgtaaagc cagcggctac atcttcatca cctactacat gcactgggtc      180

cgacagagcc ctgctcaggg acttgagtgg atgggccaga tttttcctgc cagcggcagc      240

accaactaca acgagatgtt tgagggcaga ctgaccctga ccgccgacac aagcacaaac      300

accgcctaca tggaactgag cagcctgaga agcgccgaca ccgccatgta ttattgtgcc      360

agaggcgacg gcaactacgc cctggatgct atggattatt ggggccaggg caccagcgtg      420

acagtctcga gc                                                          432


<210>  111
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1x

<400>  111

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Thr Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ser Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  112
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H618x

<400>  112
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggcgccgaag ttcggaaacc aggcgccagc      120

gtgaagattt tctgcaaggc cagcggctac accttcatca cctactacat gcactggctg      180

cggcaggccc ctgaacaagg acttgagtgg atgggccaga ttttccctgc cagcggcagc      240

accaactaca acgagatgtt tgagggcaga ctgaccctga ccgccgacac aagcacaaac      300

accgcctaca tggaactgag cagcctgaga agcgccgaca ccgccatgta ttattgtgcc      360

agaggcgacg gcaactacgc cctggatgct atggattatt ggggccaggg cgctctggtc      420

acagtctcga gc                                                          432


<210>  113
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H618x

<400>  113

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Ala Pro Glu Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120     


<210>  114
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H634x

<400>  114
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggcgccgaag ttcggaaacc aggcgccagc      120

gtgaagattt tctgcaagac cagcggctac accttcatca cctactacgt gcactggctg      180

agacaggccc ctgctcaggg atttgagtgg atgggccaga tttttcctgc cagcggcagc      240

accaactaca acgagatgtt tgagggcaga ctgaccctga ccgccgacac aagcacaaac      300

accgcctaca tggaactgag cagcctgaga agcgccgaca ccgccgtgta ttattgtgcc      360

agaggcgacg gcaactacgc cctggatgct atggattatt ggggccaggg cgctctggtc      420

acagtctcga gc                                                          432


<210>  115
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H634x

<400>  115

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Thr Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Tyr Val His Trp Leu Arg Gln Ala Pro Ala Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120     


<210>  116
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mHcLb CDR-H2x

<400>  116

Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  as mHcLb CDR-H1-WMN

<400>  117

Gly Tyr Ile Phe Ile Thr Tyr Trp Met Asn 
1               5                   10  


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mHcLb CDR-H1-MN

<400>  118

Gly Tyr Ile Phe Ile Thr Tyr Tyr Met Asn 
1               5                   10  


<210>  119
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1WMN

<400>  119
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggcgctgaag ttcggactcc tggcgcctcc      120

gtgaagattt tctgtaaagc cagcggctac atcttcatca cctactggat gaactgggtc      180

cgacagagcc ctgctcaggg acttgagtgg atgggcagca tctttcctgc cagcggcagc      240

acaagctacg cccagaaatt tcaggggaga ctgaccctga ccgccgacac aagcacaaac      300

accgcctaca tggaactgag cagcctgaga agcgccgaca ccgccatgta ttattgtgcc      360

agaggcgacg gcaactacgc cctggatgct atggattatt ggggccaggg caccagcgtg      420

acagtctcga gc                                                          432


<210>  120
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1WMN

<400>  120

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Thr Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Phe Pro Ala Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  121
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1xWMN

<400>  121
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggcgctgaag ttcggactcc tggcgcctcc      120

gtgaagattt tctgtaaagc cagcggctac atcttcatca cctactggat gaactgggtc      180

cgacagagcc ctgctcaggg acttgagtgg atgggccaga tttttcctgc cagcggcagc      240

accaactaca acgagatgtt tgagggcaga ctgaccctga ccgccgacac aagcacaaac      300

accgcctaca tggaactgag cagcctgaga agcgccgaca ccgccatgta ttattgtgcc      360

agaggcgacg gcaactacgc cctggatgct atggattatt ggggccaggg caccagcgtg      420

acagtctcga gc                                                          432


<210>  122
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1xWMN

<400>  122

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Thr Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  123
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1MN

<400>  123
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggcgctgaag ttcggactcc tggcgcctcc      120

gtgaagattt tctgtaaagc cagcggctac atcttcatca cctactacat gaactgggtc      180

cgacagagcc ctgctcaggg acttgagtgg atgggcagca tctttcctgc cagcggcagc      240

acaagctacg cccagaaatt tcaggggaga ctgaccctga ccgccgacac aagcacaaac      300

accgcctaca tggaactgag cagcctgaga agcgccgaca ccgccatgta ttattgtgcc      360

agaggcgacg gcaactacgc cctggatgct atggattatt ggggccaggg caccagcgtg      420

acagtctcga gc                                                          432


<210>  124
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1MN

<400>  124

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Thr Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ser Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ser Ile Phe Pro Ala Ser Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  125
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1xMN

<400>  125
aagcttgcca ccatggagtg gtcttgggtc tttctgttct ttctgagtgt taccaccggc       60

gtgcactcac aggtgctgct tgttcagtct ggcgctgaag ttcggactcc tggcgcctcc      120

gtgaagattt tctgtaaagc cagcggctac atcttcatca cctactacat gaactgggtc      180

cgacagagcc ctgctcaggg acttgagtgg atgggccaga tttttcctgc cagcggcagc      240

accaactaca acgagatgtt tgagggcaga ctgaccctga ccgccgacac aagcacaaac      300

accgcctaca tggaactgag cagcctgaga agcgccgaca ccgccatgta ttattgtgcc      360

agaggcgacg gcaactacgc cctggatgct atggattatt ggggccaggg caccagcgtg      420

acagtctcga gc                                                          432


<210>  126
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FelHcLb-H1-1xMN

<400>  126

Gln Val Leu Leu Val Gln Ser Gly Ala Glu Val Arg Thr Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Phe Cys Lys Ala Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ser Pro Ala Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Leu Thr Leu Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Ala Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  127
<211>  335
<212>  PRT
<213>  Canis familiaris

<400>  127

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln 
145                 150                 155                 160 


Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys 
        195                 200                 205             


Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser 
225                 230                 235                 240 


Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys 
                245                 250                 255     


Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln 
            260                 265                 270         


Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu 
        275                 280                 285             


Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg 
    290                 295                 300                 


Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu 
305                 310                 315                 320 


His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335 


<210>  128
<211>  1011
<212>  DNA
<213>  Canis familiaris

<400>  128
gcctcaacaa ctgctcctag cgtgtttccc ctggccccta gctgcggaag tacctcaggc       60

agcacagtgg ccctggcttg tctggtgtct ggatatttcc ctgagccagt gaccgtgagt      120

tggaacagcg gctctctgac ctccggggtg cacacatttc catctgtgct gcagtctagt      180

ggcctgtact ccctgtcaag catggtgact gtgccttcct ctaggtggcc atcagaaact      240

ttcacctgca acgtggccca tcccgccagc aagaccaaag tggacaagcc cgtgcctaaa      300

agggagaatg gaagggtgcc aagaccacct gattgcccta agtgtccagc tccagaagcg      360

gcgggagcac caagcgtgtt catctttcca cccaagccca aagacacact gctgattgct      420

agaactcccg aggtgacctg cgtggtggtg gacctggatc cagaggaccc cgaagtgcag      480

atctcctggt tcgtggatgg gaagcagatg cagacagcca aaactcagcc tcgggaggaa      540

cagtttaacg gaacctatag agtggtgtct gtgctgccaa ttggacacca ggactggctg      600

aagggcaaac agtttacatg caaggtgaac aacaaggccc tgcctagtcc aatcgagagg      660

actatttcaa aagctagggg acaggctcat cagccttccg tgtatgtgct gcctccatcc      720

cgggaggaac tgtctaagaa cacagtgagt ctgacttgtc tgatcaaaga tttctttccc      780

cctgacattg atgtggagtg gcagagcaat gggcagcagg agccagaatc caagtacaga      840

accacaccac cccagctgga cgaagatggc tcctatttcc tgtacagtaa gctgtcagtg      900

gacaaatcta ggtggcagcg cggggatacc tttatctgcg ccgtgatgca cgaggctctg      960

cacaatcatt acacacaaga aagtctgtca catagccccg gcaagtagta g              1011


<210>  129
<211>  106
<212>  PRT
<213>  Canis familiaris

<400>  129

Arg Asn Asp Ala Gln Pro Ala Val Tyr Leu Phe Gln Pro Ser Pro Asp 
1               5                   10                  15      


Gln Leu His Thr Gly Ser Ala Ser Val Val Cys Leu Leu Asn Ser Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Val Asp Gly Val Ile Gln 
        35                  40                  45              


Asp Thr Gly Ile Gln Glu Ser Val Thr Glu Gln Asp Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Leu Ser 
65                  70                  75                  80  


His Glu Leu Tyr Ser Cys Glu Ile Thr His Lys Ser Leu Pro Ser Thr 
                85                  90                  95      


Leu Ile Lys Ser Phe Gln Arg Ser Glu Cys 
            100                 105     


<210>  130
<211>  324
<212>  DNA
<213>  Canis familiaris

<400>  130
cggaacgacg cccagcccgc cgtgtacctg ttccagccca gccccgatca gctgcacacc       60

ggcagcgctt cagtcgtctg cctgctgaac agcttctacc ccaaggacat caacgtgaag      120

tggaaggtgg acggcgtgat ccaggacacc ggcatccagg aaagcgtcac cgagcaggac      180

aaggacagca cctacagcct gagcagcacc ctgaccatgt ccagcaccga gtacctgagc      240

cacgagctgt atagctgcga gatcacccac aagagcctgc ctagcaccct gatcaagagc      300

ttccagcgga gcgagtgcta gtag                                             324


<210>  131
<211>  335
<212>  PRT
<213>  Felis catus

<400>  131

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu Val Leu Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Pro Pro Glu Ala Ala Gly Ala Pro Ser Ile Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln 
145                 150                 155                 160 


Ile Thr Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys 
        195                 200                 205             


Val Asn Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala 
225                 230                 235                 240 


Gln Glu Glu Leu Ser Arg Asn Lys Val Ser Val Thr Cys Leu Ile Lys 
                245                 250                 255     


Ser Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln 
            260                 265                 270         


Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser 
        275                 280                 285             


Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His 
    290                 295                 300                 


Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu 
305                 310                 315                 320 


His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
                325                 330                 335 


<210>  132
<211>  1011
<212>  DNA
<213>  Felis catus

<400>  132
gcctccacca cggccccatc ggtgttccca ctggccccca gctgcgggac cacatctggc       60

gccaccgtgg ccctggcctg cctggtgtta ggctacttcc ctgagccggt gaccgtgtcc      120

tggaactccg gcgccctgac cagcggtgtg cacaccttcc cggccgtcct gcaggcctcg      180

gggctgtact ctctcagcag catggtgaca gtgccctcca gcaggtggct cagtgacacc      240

ttcacctgca acgtggccca cccgcccagc aacaccaagg tggacaagac cgtgcgcaaa      300

acagaccacc caccgggacc caaaccctgc gactgtccca aatgcccacc ccctgagatg      360

cttggaggac cgtccatctt catcttcccc ccaaaaccca aggacaccct ctcgatttcc      420

cggacgcccg aggtcacatg cttggtggtg gacttgggcc cagatgactc cgatgtccag      480

atcacatggt ttgtggataa cacccaggtg tacacagcca agacgagtcc gcgtgaggag      540

cagttcaaca gcacctaccg tgtggtcagt gtcctcccca tcctacacca ggactggctc      600

aaggggaagg agttcaagtg caaggtcaac agcaaatccc tcccctcccc catcgagagg      660

accatctcca aggccaaagg acagccccac gagccccagg tgtacgtcct gcctccagcc      720

caggaggagc tcagcaggaa caaagtcagt gtgacctgcc tgatcaaatc cttccacccg      780

cctgacattg ccgtcgagtg ggagatcacc ggacagccgg agccagagaa caactaccgg      840

acgaccccgc cccagctgga cagcgacggg acctacttcg tgtacagcaa gctctcggtg      900

gacaggtccc actggcagag gggaaacacc tacacctgct cggtgtcaca cgaagctctg      960

cacagccacc acacacagaa atccctcacc cagtctccgg gtaaatagta g              1011


<210>  133
<211>  110
<212>  PRT
<213>  Felis catus

<400>  133

Arg Ser Asp Ala Gln Pro Ser Val Phe Leu Phe Gln Pro Ser Leu Asp 
1               5                   10                  15      


Glu Leu His Thr Gly Ser Ala Ser Ile Val Cys Ile Leu Asn Asp Phe 
            20                  25                  30          


Tyr Pro Lys Glu Val Asn Val Lys Trp Lys Val Asp Gly Val Val Gln 
        35                  40                  45              


Asn Lys Gly Ile Gln Glu Ser Thr Thr Glu Gln Asn Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Met Ser Ser Thr Glu Tyr Gln 
65                  70                  75                  80  


Ser His Glu Lys Phe Ser Cys Glu Val Thr His Lys Ser Leu Ala Ser 
                85                  90                  95      


Thr Leu Val Lys Ser Phe Gln Arg Ser Glu Cys Gln Arg Glu 
            100                 105                 110 


<210>  134
<211>  336
<212>  DNA
<213>  Felis catus

<400>  134
cggagtgatg ctcagccatc tgtctttctc ttccaaccat ctctggacga gttacataca       60

ggaagtgcct ctatcgtgtg catattgaat gacttctacc ccaaagaggt caatgtcaag      120

tggaaagtgg atggcgtagt ccaaaacaaa ggcatccagg agagcaccac agagcagaac      180

agcaaggaca gcacctacag cctcagcagc accctgacga tgtccagtac ggagtaccaa      240

agtcatgaaa agttctcctg cgaggtcact cacaagagcc tggcctccac cctcgtcaag      300

agcttccaga ggagcgagtg tcagagagag tgatga                                336


<210>  135
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D108E amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  135

Gly Glu Tyr Ser Gly Tyr Asp Thr Glu Pro Gln Tyr Ser 
1               5                   10              


<210>  136
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D108P amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  136

Gly Glu Tyr Ser Gly Tyr Asp Thr Pro Pro Gln Tyr Ser 
1               5                   10              


<210>  137
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D108Q amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  137

Gly Glu Tyr Ser Gly Tyr Asp Thr Gln Pro Gln Tyr Ser 
1               5                   10              


<210>  138
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D108N amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  138

Gly Glu Tyr Ser Gly Tyr Asp Thr Asn Pro Gln Tyr Ser 
1               5                   10              


<210>  139
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D108S amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  139

Gly Glu Tyr Ser Gly Tyr Asp Thr Ser Pro Gln Tyr Ser 
1               5                   10              


<210>  140
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D108T amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  140

Gly Glu Tyr Ser Gly Tyr Asp Thr Thr Pro Gln Tyr Ser 
1               5                   10              


<210>  141
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D108K amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  141

Gly Glu Tyr Ser Gly Tyr Asp Thr Lys Pro Gln Tyr Ser 
1               5                   10              


<210>  142
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D108R amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  142

Gly Glu Tyr Ser Gly Tyr Asp Thr Arg Pro Gln Tyr Ser 
1               5                   10              


<210>  143
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D108H amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  143

Gly Glu Tyr Ser Gly Tyr Asp Thr His Pro Gln Tyr Ser 
1               5                   10              


<210>  144
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P109S amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  144

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Ser Gln Tyr Ser 
1               5                   10              


<210>  145
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P109H amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  145

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp His Gln Tyr Ser 
1               5                   10              


<210>  146
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P109Y amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  146

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Tyr Gln Tyr Ser 
1               5                   10              


<210>  147
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P109W amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  147

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Trp Gln Tyr Ser 
1               5                   10              


<210>  148
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P109F amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  148

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Phe Gln Tyr Ser 
1               5                   10              


<210>  149
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P109T amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  149

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Thr Gln Tyr Ser 
1               5                   10              


<210>  150
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P109A amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  150

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Ala Gln Tyr Ser 
1               5                   10              


<210>  151
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P109G amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  151

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Gly Gln Tyr Ser 
1               5                   10              


<210>  152
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q110S amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  152

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Ser Tyr Ser 
1               5                   10              


<210>  153
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q110N amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  153

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Asn Tyr Ser 
1               5                   10              


<210>  154
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q110D amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  154

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Asp Tyr Ser 
1               5                   10              


<210>  155
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q110E amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  155

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Glu Tyr Ser 
1               5                   10              


<210>  156
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q110K amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  156

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Lys Tyr Ser 
1               5                   10              


<210>  157
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q110R amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  157

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Arg Tyr Ser 
1               5                   10              


<210>  158
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q110H amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  158

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro His Tyr Ser 
1               5                   10              


<210>  159
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q110T amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  159

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Thr Tyr Ser 
1               5                   10              


<210>  160
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q110V amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  160

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Val Tyr Ser 
1               5                   10              


<210>  161
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y111P amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  161

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Pro Ser 
1               5                   10              


<210>  162
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y111F amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  162

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Phe Ser 
1               5                   10              


<210>  163
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y111W amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  163

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Trp Ser 
1               5                   10              


<210>  164
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y111H amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  164

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln His Ser 
1               5                   10              


<210>  165
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y111M amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  165

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Met Ser 
1               5                   10              


<210>  166
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y111I amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  166

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Ile Ser 
1               5                   10              


<210>  167
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y111L amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  167

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Leu Ser 
1               5                   10              


<210>  168
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y111V amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  168

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Val Ser 
1               5                   10              


<210>  169
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y111T amino acid sequence in CDR H3  in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  169

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Thr Ser 
1               5                   10              


<210>  170
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Y111E amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  170

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Glu Ser 
1               5                   10              


<210>  171
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S112E) amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  171

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Glu 
1               5                   10              


<210>  172
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S112Q amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  172

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Gln 
1               5                   10              


<210>  173
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S112N amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  173

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Asn 
1               5                   10              


<210>  174
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S112T amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  174

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Thr 
1               5                   10              


<210>  175
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S112A amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  175

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Ala 
1               5                   10              


<210>  176
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S112G amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  176

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Gly 
1               5                   10              


<210>  177
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S112P amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  177

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Pro 
1               5                   10              


<210>  178
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S112D amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  178

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Asp 
1               5                   10              


<210>  179
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S112L amino acid sequence in CDR H3 in the heavy chain variable 
       region (VH) of Can SL501-VH3

<400>  179

Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Leu 
1               5                   10              


<210>  180
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   (VH) of affinity matured caninized Hclb H1K4 antibody  
       HcLb/mat/P/H3/100/DY

<400>  180
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatc acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag caagcggatc taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  181
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody  
       HcLb/mat/P/H3/100/DY

<400>  181

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  182
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       HcLb/mat/P/H2/55/SW

<400>  182
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatc acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggatc taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggcgac      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  183
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody  
       HcLb/mat/P/H2/55/SW

<400>  183

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  184
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/54AG/100DY

<400>  184
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatc acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag gaagcggatc taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  185
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/54AG/100DY

<400>  185

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Gly Ser Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  186
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY

<400>  186
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatc acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggatc taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  187
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody  
       canHcLb/55SW/100DY

<400>  187

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  188
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/28/TI

<400>  188
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tatatttatc acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggatc taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  189
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/28/TI

<400>  189

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Ile Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  190
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/30/IM

<400>  190
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatg acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggatc taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  191
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/30/IM

<400>  191

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Met Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  192
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody  
       CanHcLb/55SW/100DY/57/SM

<400>  192
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatc acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggaat gaccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  193
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       CanHcLb/55SW/100DY/57/SM

<400>  193

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Met Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  194
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/57/SV

<400>  194
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatc acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggagt taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  195
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody referred to
       herein as canHcLb/55SW/100DY/57/SV

<400>  195

Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Thr 
            20                  25                  30          


Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp 
        35                  40                  45              


Met Gly Gln Ile Phe Pro Ala Trp Gly Val Thr Asn Tyr Asn Glu Met 
    50                  55                  60                  


Phe Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  196
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/31/TK

<400>  196
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatc aaatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggatc taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  197
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/31/TK

<400>  197

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Ile Lys Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  198
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/30IM/31TK

<400>  198
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatg aaatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggatc taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  199
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/30IM/31TK

<400>  199

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Met Lys Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  200
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/30IM/31TK/28TI

<400>  200
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tatatttatg aaatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggatc taccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  201
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/30IM/31TK/28TI

<400>  201

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Ile Phe Met Lys Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Ser Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  202
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/30IM/31TK/57SM

<400>  202
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatg aaatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggaat gaccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  203
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/30IM/31TK/57SM

<400>  203

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Met Lys Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Met Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  204
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/30IM/31TK/28TI/57SM

<400>  204
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tatatttatg aaatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggaat gaccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  205
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/30IM/31TK/28TI/57SM

<400>  205

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Ile Phe Met Lys Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Met Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  206
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody  
       canHcLb/55SW/100DY/57SM/30IM

<400>  206
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatg acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggaat gaccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  207
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/57SM/30IM

<400>  207

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Met Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Met Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  208
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/57SV/30IM

<400>  208
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatg acatactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggaat gaccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  209
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/57SV/30IM

<400>  209

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Met Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Met Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  210
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/57SM/30IM/31TF

<400>  210
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata tacatttatg ttctactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggaat gaccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  211
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/57SM/30IM/31TF

<400>  211

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Thr Phe Met Phe Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Met Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  212
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/57SM/30IM/31TF/28TK

<400>  212
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata taaatttatg ttctactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggaat gaccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  213
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/57SM/30IM/31TF/28TK

<400>  213

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Lys Phe Met Phe Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Met Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  214
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/57SM/30IW/31TF/28TK

<400>  214
gaggtgcagt tggttcagtc cggcgccgag gtgaagaagc ccggggcctc tgtaaaggtc       60

agctgcaaga ctagcggata taaattttgg ttctactgga tgaactgggt ccgacaagcc      120

cctggtgccg gcctggattg gatgggccag atcttcccag catggggaat gaccaattac      180

aatgagatgt tcgagggtag ggtgaccctc acagctgata ccagtacttc aactgcatac      240

atggaactga gttccctgag agcaggcgac atcgcagttt actattgtgc ccgaggctat      300

ggcaattatg cactggatgc tatggactac tggggtcagg gaaccctggt gacagtctcg      360

agc                                                                    363


<210>  215
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/55SW/100DY/57SM/30IW/31TF/28TK

<400>  215

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Thr Ser Gly Tyr Lys Phe Trp Phe Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Ala Gly Leu Asp Trp Met 
        35                  40                  45              


Gly Gln Ile Phe Pro Ala Trp Gly Met Thr Asn Tyr Asn Glu Met Phe 
    50                  55                  60                  


Glu Gly Arg Val Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ala Gly Asp Ile Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  216
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VL) of affinity matured caninized Hclb H1K4 antibody 
       HcLb/mat/K3/237/ND

<400>  216
gatattgtga tgacacagac tccaccctcc ctttctgtca gccctcggga gaccgcctcc       60

attagctgtc gcgccagtga gtccgtcgat tcctacggaa atagcttcat gcactggtat      120

ctgcagaaac caggtcagtc tcctcaattg ctgatctacc tggcttctaa cctggaaagc      180

ggtgtgtcag ataggttttc cggaagtggt agcggaactg actttaccct gcgtatttcc      240

cgagtggaag ccaatgacac tggtgtttac tactgtcagc agaatgacga agaccccctg      300

acctttggcc agggtaccaa g                                                321


<210>  217
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VL) of affinity matured caninized Hclb H1K4 antibody 
       HcLb/mat/K3/237/ND

<400>  217

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Ser Val Ser Pro Arg 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Ser Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asn Asp Thr Gly Val Tyr Tyr Cys Gln Gln Asn Asp 
                85                  90                  95      


Glu Asp Pro Leu Thr Phe Gly Gln Gly Thr Lys 
            100                 105         


<210>  218
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  (VL) of affinity matured caninized Hclb H1K4 antibody 
       canHcLb/237ND/242TS

<400>  218
gatattgtga tgacacagac tccaccctcc ctttctgtca gccctcggga gaccgcctcc       60

attagctgtc gcgccagtga gtccgtcgat tcctacggaa atagcttcat gcactggtat      120

ctgcagaaac caggtcagtc tcctcaattg ctgatctacc tggcttctaa cctggaaagc      180

ggtgtgtcag ataggttttc cggaagtggt agcggaactg actttaccct gcgtatttcc      240

cgagtggaag ccaatgacac tggtgtttac tactgtcagc agaatgacga agaccccctg      300

agctttggcc agggtaccaa g                                                321


<210>  219
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VL) of affinity matured caninized Hclb H1K4 antibody  
       canHcLb/237ND/242TS

<400>  219

Asp Ile Val Met Thr Gln Thr Pro Pro Ser Leu Ser Val Ser Pro Arg 
1               5                   10                  15      


Glu Thr Ala Ser Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Ser Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Asn Asp Thr Gly Val Tyr Tyr Cys Gln Gln Asn Asp 
                85                  90                  95      


Glu Asp Pro Leu Ser Phe Gly Gln Gly Thr Lys 
            100                 105         


<210>  220
<211>  390
<212>  PRT
<213>  Canis familiaris

<400>  220

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Arg Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ser Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Val Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Asn Thr Asn Lys Ile Tyr Glu Lys Val Lys Lys Ser Pro 
        115                 120                 125             


His Ser Ile Tyr Met Leu Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Ala Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asp Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Thr 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser His Gly Gly Glu Val Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Lys Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Ser 
225                 230                 235                 240 


Ser Ser Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu His 
            260                 265                 270         


Ser Ser Arg Gln Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  221
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  222
<211>  390
<212>  PRT
<213>  Felis catus

<400>  222

Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Asn Thr Asn Lys Ile Tyr Glu Lys Val Gln Arg Thr Pro 
        115                 120                 125             


His Ser Ile Tyr Met Leu Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Ala Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Thr 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser His Gly Gly Glu Val Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Lys Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Ser 
225                 230                 235                 240 


Ser Ser Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu His 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  223
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGFB1 FRAGMENT CONTAINING EPITOPE AS IN FIGURE 1

<400>  223

Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210>  224
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 of the SL501 antibody: "TGEYSGYDT(X1)( X2) (X3)( X4)"  
       wherein (X1) can be (K or R),  wherein (X2) can be (T or A), 
       wherein (X3) can be (Q, N, D, E or K) and wherein X4 can be (S, 
       E, Q or D)


<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  REPLACE="R"

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  REPLACE="A"

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  REPLACE="N" or "D" or "E" or "K"

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  REPLACE="E" or "Q" or "D"

<400>  224

Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Lys Thr Gln Ser 
1               5                   10              


<210>  225
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the D108E point 
       mutation

<400>  225

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Glu Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  226
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the D108P point 
       mutation

<400>  226

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Pro Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  227
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the D108Q point 
       mutation

<400>  227

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Gln Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  228
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the D108N point 
       mutation

<400>  228

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asn Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  229
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the D108S point 
       mutation

<400>  229

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Ser Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  230
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the D108T point 
       mutation

<400>  230

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Thr Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  231
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the D108K point 
       mutation

<400>  231

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Lys Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  232
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the D108R point 
       mutation

<400>  232

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Arg Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  233
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the D108H point 
       mutation

<400>  233

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr His Pro Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  234
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the P109S point 
       mutation

<400>  234

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Ser Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  235
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the P109H point 
       mutation

<400>  235

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp His Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  236
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the P109Y point 
       mutation

<400>  236

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Tyr Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  237
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the P109W point 
       mutation

<400>  237

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Trp Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  238
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the P109F point 
       mutation

<400>  238

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Phe Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  239
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the P109T point 
       mutation

<400>  239

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Thr Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  240
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the P109A point 
       mutation

<400>  240

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Ala Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  241
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the P109G point 
       mutation

<400>  241

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Gly Gln Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  242
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Q110S point 
       mutation

<400>  242

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Ser Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  243
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Q110N point 
       mutation

<400>  243

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Asn Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  244
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Q110D point 
       mutation

<400>  244

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Asp Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  245
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Q110E point 
       mutation

<400>  245

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Glu Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  246
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Q110K point 
       mutation

<400>  246

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Lys Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  247
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Q110R point 
       mutation

<400>  247

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Arg Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  248
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Q110H point 
       mutation

<400>  248

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro His Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  249
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Q110T point 
       mutation

<400>  249

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Thr Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  250
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Q110V point 
       mutation

<400>  250

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Val Tyr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  251
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Y111P point 
       mutation

<400>  251

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Pro Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  252
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Y111F point 
       mutation

<400>  252

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Phe Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  253
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Y111W point 
       mutation

<400>  253

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Trp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  254
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Y111H point 
       mutation

<400>  254

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln His Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  255
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Y111M point 
       mutation

<400>  255

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Met Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  256
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Y111I point 
       mutation

<400>  256

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Ile Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  257
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Y111L point 
       mutation

<400>  257

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Leu Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  258
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Y111V point 
       mutation

<400>  258

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Val Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  259
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Y111T point 
       mutation

<400>  259

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Thr Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  260
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the Y111E point 
       mutation

<400>  260

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Glu Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  261
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the S112E point 
       mutation

<400>  261

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Glu 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  262
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the S112Q point 
       mutation

<400>  262

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Gln 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  263
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the S112N point 
       mutation

<400>  263

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Asn 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  264
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the S112T point 
       mutation

<400>  264

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Thr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  265
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the S112A point 
       mutation

<400>  265

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Ala 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  266
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the S112G point 
       mutation

<400>  266

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Gly 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  267
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the S112P point 
       mutation

<400>  267

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  268
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the S112D point 
       mutation

<400>  268

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Asp 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  269
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) of caninized SL501 antibody comprising the S112L point 
       mutation

<400>  269

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Glu Tyr Ser Gly Tyr Asp Thr Asp Pro Gln Tyr Leu 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  270
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) CDR1 of the HcLB mAb comprising the amino acid sequence of: 
       G-Y-(X1)-F-(X2)-(X3)-Y wherein (X1) comprises T or I, (X2) 
       comprises I or M and (X3) comprises T or K.


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  REPLACE= I

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  REPLACE= M

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  REPLACE= K

<400>  270

Gly Tyr Thr Phe Ile Thr Tyr 
1               5           


<210>  271
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) CDR2 of the HcLB mAb comprising the amino acid sequence of: 
       F-P-(X4)-(X5)-G-(X6) wherein (X4) comprises A or G, (X5) 
       comprises S or W and (X6) comprises S, M or V


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  REPLACE= G

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  REPLACE= W

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  REPLACE= M or V

<400>  271

Phe Pro Ala Ser Gly Ser 
1               5       


<210>  272
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VH) CDR3 of the HcLB  mAb comprising the amino acid sequence of:
       G-(X7)-G-N-Y-A-L-D-A-M-D-Y wherein (X7) comprises D or Y.


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  REPLACE= Y

<400>  272

Gly Asp Gly Asn Tyr Ala Leu Asp 
1               5               


<210>  273
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (VL) CDR3 of the HcLB mAb comprising the amino acid sequence of: 
       Q-Q-N-(X8)-E-D-P-L-(X9) wherein (X8) comprises N or D and (X9) 
       comprises T or S


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  REPLACE= D

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  REPLACE= D

<400>  273

Gln Gln Asn Asn Glu Asp Pro Leu Thr 
1               5                   


<210>  274
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of the variable region of the heavy chain (VH) the HcLB 
       antibody comprising the T28I point mutation

<400>  274

Gly Tyr Ile Phe Ile Thr Tyr 
1               5           


<210>  275
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of the variable region of the heavy chain (VH) of the HcLB 
       antibody comprising the I30M point mutation

<400>  275

Gly Tyr Ile Phe Met Thr Tyr 
1               5           


<210>  276
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1of the variable region of the heavy chain (VH) of the HcLB 
       antibody comprising the T31K point mutation

<400>  276

Gly Tyr Thr Phe Ile Lys Tyr 
1               5           


<210>  277
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1of the variable region of the heavy chain (VH) of the HcLB 
       antibody comprising the I30M and T31K point mutation

<400>  277

Gly Tyr Ile Phe Met Lys Tyr 
1               5           


<210>  278
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1of the variable region of the heavy chain (VH) of the HcLB 
       antibody comprising the T28I, I30M and T31K point mutations

<400>  278

Gly Tyr Ile Phe Met Lys Tyr 
1               5           


<210>  279
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2of the variable region of the heavy chain (VH) of the HcLB 
       antibody comprising the A54G point mutation

<400>  279

Phe Pro Gly Ser Gly Ser 
1               5       


<210>  280
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of the variable region of the heavy chain (VH) of the HcLB 
       antibody comprising the S55W point mutation

<400>  280

Phe Pro Ala Trp Gly Ser 
1               5       


<210>  281
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of the variable region of the heavy chain (VH) of the HcLB 
       antibody comprising the S57M point mutation

<400>  281

Phe Pro Ala Ser Gly Met 
1               5       


<210>  282
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of the variable region of the heavy chain (VH) of the HcLB 
       antibody comprising the S55W and S57M point mutations

<400>  282

Phe Pro Ala Trp Gly Met 
1               5       


<210>  283
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the variable region of the heavy chain (VH) of the HcLB 
       antibody comprising the D100Y point mutation

<400>  283

Gly Tyr Gly Asn Tyr Ala Leu Asp Ala Met Asp Tyr 
1               5                   10          


<210>  284
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the variable region of the light chain (VL) of the HcLB 
       antibody comprising the N237D point mutation

<400>  284

Gln Gln Asn Asp Glu Asp Pro Leu Thr 
1               5                   


<210>  285
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the variable region of the light chain (VH) of the HcLB 
       antibody comprising the T242S point mutation

<400>  285

Gln Gln Asn Asn Glu Asp Pro Leu Ser 
1               5                   


<210>  286
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of the variable region of the light chain (VL) of the HcLB 
       antibody comprising the N237D and T242S point mutations

<400>  286

Gln Gln Asn Asp Glu Asp Pro Leu Ser 
1               5                   


<210>  287
<211>  1005
<212>  DNA
<213>  Canis familiaris

<400>  287
gcctcaacaa ctgctcctag cgtgtttccc ctggccccta gctgcggaag tacctcaggc       60

agcacagtgg ccctggcttg tctggtgtct ggatatttcc ctgagccagt gaccgtgagt      120

tggaacagcg gctctctgac ctccggggtg cacacatttc catctgtgct gcagtctagt      180

ggcctgtact ccctgtcaag catggtgact gtgccttcct ctaggtggcc atcagaaact      240

ttcacctgca acgtggccca tcccgccagc aagaccaaag tggacaagcc cgtgcctaaa      300

agggagaatg gaagggtgcc aagaccacct gattgcccta agtgtccagc tccagaagcg      360

gcgggagcac caagcgtgtt catctttcca cccaagccca aagacacact gctgattgct      420

agaactcccg aggtgacctg cgtggtggtg gacctggatc cagaggaccc cgaagtgcag      480

atctcctggt tcgtggatgg gaagcagatg cagacagcca aaactcagcc tcgggaggaa      540

cagtttaacg gaacctatag agtggtgtct gtgctgccaa ttggacacca ggactggctg      600

aagggcaaac agtttacatg caaggtgaac aacaaggccc tgcctagtcc aatcgagagg      660

actatttcaa aagctagggg acaggctcat cagccttccg tgtatgtgct gcctccatcc      720

cgggaggaac tgtctaagaa cacagtgagt ctgacttgtc tgatcaaaga tttctttccc      780

cctgacattg atgtggagtg gcagagcaat gggcagcagg agccagaatc caagtacaga      840

accacaccac cccagctgga cgaagatggc tcctatttcc tgtacagtaa gctgtcagtg      900

gacaaatcta ggtggcagcg cggggatacc tttatctgcg ccgtgatgca cgaggctctg      960

cacaatcatt acacacaaga aagtctgtca catagccccg gcaag                     1005


<210>  288
<211>  335
<212>  PRT
<213>  Canis familiaris

<400>  288

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln 
145                 150                 155                 160 


Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys 
        195                 200                 205             


Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser 
225                 230                 235                 240 


Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys 
                245                 250                 255     


Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln 
            260                 265                 270         


Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu 
        275                 280                 285             


Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg 
    290                 295                 300                 


Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu 
305                 310                 315                 320 


His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335 


<210>  289
<211>  1005
<212>  DNA
<213>  Felis catus

<400>  289
gcctccacca cggccccatc ggtgttccca ctggccccca gctgcgggac cacatctggc       60

gccaccgtgg ccctggcctg cctggtgtta ggctacttcc ctgagccggt gaccgtgtcc      120

tggaactccg gcgccctgac cagcggtgtg cacaccttcc cggccgtcct gcaggcctcg      180

gggctgtact ctctcagcag catggtgaca gtgccctcca gcaggtggct cagtgacacc      240

ttcacctgca acgtggccca cccgcccagc aacaccaagg tggacaagac cgtgcgcaaa      300

acagaccacc caccgggacc caaaccctgc gactgtccca aatgcccacc ccctgagatg      360

cttggaggac cgtccatctt catcttcccc ccaaaaccca aggacaccct ctcgatttcc      420

cggacgcccg aggtcacatg cttggtggtg gacttgggcc cagatgactc cgatgtccag      480

atcacatggt ttgtggataa cacccaggtg tacacagcca agacgagtcc gcgtgaggag      540

cagttcaaca gcacctaccg tgtggtcagt gtcctcccca tcctacacca ggactggctc      600

aaggggaagg agttcaagtg caaggtcaac agcaaatccc tcccctcccc catcgagagg      660

accatctcca aggccaaagg acagccccac gagccccagg tgtacgtcct gcctccagcc      720

caggaggagc tcagcaggaa caaagtcagt gtgacctgcc tgatcaaatc cttccacccg      780

cctgacattg ccgtcgagtg ggagatcacc ggacagccgg agccagagaa caactaccgg      840

acgaccccgc cccagctgga cagcgacggg acctacttcg tgtacagcaa gctctcggtg      900

gacaggtccc actggcagag gggaaacacc tacacctgct cggtgtcaca cgaagctctg      960

cacagccacc acacacagaa atccctcacc cagtctccgg gtaaa                     1005


<210>  290
<211>  335
<212>  PRT
<213>  Felis catus

<400>  290

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Thr Thr Ser Gly Ala Thr Val Ala Leu Ala Cys Leu Val Leu Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ala Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Leu Ser Asp Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Arg Lys Thr Asp His Pro Pro Gly Pro Lys Pro Cys Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Pro Pro Glu Met Leu Gly Gly Pro Ser Ile Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Ser Ile Ser Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Leu Val Val Asp Leu Gly Pro Asp Asp Ser Asp Val Gln 
145                 150                 155                 160 


Ile Thr Trp Phe Val Asp Asn Thr Gln Val Tyr Thr Ala Lys Thr Ser 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Leu His Gln Asp Trp Leu Lys Gly Lys Glu Phe Lys Cys Lys 
        195                 200                 205             


Val Asn Ser Lys Ser Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Lys Gly Gln Pro His Glu Pro Gln Val Tyr Val Leu Pro Pro Ala 
225                 230                 235                 240 


Gln Glu Glu Leu Ser Arg Asn Lys Val Ser Val Thr Cys Leu Ile Lys 
                245                 250                 255     


Ser Phe His Pro Pro Asp Ile Ala Val Glu Trp Glu Ile Thr Gly Gln 
            260                 265                 270         


Pro Glu Pro Glu Asn Asn Tyr Arg Thr Thr Pro Pro Gln Leu Asp Ser 
        275                 280                 285             


Asp Gly Thr Tyr Phe Val Tyr Ser Lys Leu Ser Val Asp Arg Ser His 
    290                 295                 300                 


Trp Gln Arg Gly Asn Thr Tyr Thr Cys Ser Val Ser His Glu Ala Leu 
305                 310                 315                 320 


His Ser His His Thr Gln Lys Ser Leu Thr Gln Ser Pro Gly Lys 
                325                 330                 335 


<210>  291
<211>  1008
<212>  DNA
<213>  Canis familiaris

<400>  291
gcctcaacaa ctgctcctag cgtgtttccc ctggccccta gctgcggaag tacctcaggc       60

agcacagtgg ccctggcttg tctggtgtct ggatatttcc ctgagccagt gaccgtgagt      120

tggaacagcg gctctctgac ctccggggtg cacacatttc catctgtgct gcagtctagt      180

ggcctgtact ccctgtcaag catggtgact gtgccttcct ctaggtggcc atcagaaact      240

ttcacctgca acgtggccca tcccgccagc aagaccaaag tggacaagcc cgtgcctaaa      300

agggagaatg gaagggtgcc aagaccacct gattgcccta agtgtccagc tccagaaatg      360

ctgggaggac caagcgtgtt catctttcca cccaagccca aagacacact gctgattgct      420

agaactcccg aggtgacctg cgtggtggtg gacctggatc cagaggaccc cgaagtgcag      480

atctcctggt tcgtggatgg gaagcagatg cagacagcca aaactcagcc tcgggaggaa      540

cagtttaacg gaacctatag agtggtgtct gtgctgccaa ttggacacca ggactggctg      600

aagggcaaac agtttacatg caaggtgaac aacaaggccc tgcctagtcc aatcgagagg      660

actatttcaa aagctagggg acaggctcat cagccttccg tgtatgtgct gcctccatcc      720

cgggaggaac tgtctaagaa cacagtgagt ctgacttgtc tgatcaaaga tttctttccc      780

cctgacattg atgtggagtg gcagagcaat gggcagcagg agccagaatc caagtacaga      840

accacaccac cccagctgga cgaagatggc tcctatttcc tgtacagtaa gctgtcagtg      900

gacaaatcta ggtggcagcg cggggatacc tttatctgcg ccgtgatgca cgaggctctg      960

cacaatcatt acacacaaga aagtctgtca catagccccg gcaagtag                  1008


<210>  292
<211>  335
<212>  PRT
<213>  Canis familiaris

<400>  292

Ala Ser Thr Thr Ala Pro Ser Val Phe Pro Leu Ala Pro Ser Cys Gly 
1               5                   10                  15      


Ser Thr Ser Gly Ser Thr Val Ala Leu Ala Cys Leu Val Ser Gly Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ser Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Met Val Thr Val Pro Ser Ser Arg Trp Pro Ser Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Asn Val Ala His Pro Ala Ser Lys Thr Lys Val Asp Lys 
                85                  90                  95      


Pro Val Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys 
            100                 105                 110         


Pro Lys Cys Pro Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile 
        115                 120                 125             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu 
    130                 135                 140                 


Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln 
145                 150                 155                 160 


Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln 
                165                 170                 175     


Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu 
            180                 185                 190         


Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys 
        195                 200                 205             


Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys 
    210                 215                 220                 


Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser 
225                 230                 235                 240 


Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys 
                245                 250                 255     


Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln 
            260                 265                 270         


Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu 
        275                 280                 285             


Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg 
    290                 295                 300                 


Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu 
305                 310                 315                 320 


His Asn His Tyr Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
                325                 330                 335 


<210>  293
<211>  309
<212>  DNA
<213>  artificial sequence

<220>
<223>  Can SL501-VK1

<400>  293
gaaattgtga tgacccagag cccggcgagc ctgagcctga gccaggaaga aaaagtgacc       60

attacctgcc gcgcgagcca gggcattggc gatgatctgg gctggtatca gcagaaaccg      120

ggccaggcgc cgaaactgct gatttatggc accagcaccc tgcagagcgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttagcttta ccattagcag cctggaaccg      240

gaagatgtgg cggtgtatta ttgcctgcag gatagcaact atccgctgac ctttggcgcg      300

ggcaccaaa                                                              309


