                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  Methods and Compositions for Modulating Toll-Like Receptor 3 
       (TLR3) Function

<130>  034044.205WO3

<150>  US 63/038,582
<151>  2020-06-12

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  598
<212>  PRT
<213>  Mus musculus

<400>  1

Met Glu Val Glu Pro Pro Leu Tyr Pro Val Ala Gly Ala Ala Gly Pro 
1               5                   10                  15      


Gln Gly Asp Glu Asp Arg His Gly Val Pro Asp Gly Pro Glu Ala Pro 
            20                  25                  30          


Leu Asp Glu Leu Val Gly Ala Tyr Pro Asn Tyr Asn Glu Glu Glu Glu 
        35                  40                  45              


Glu Arg Arg Tyr Tyr Arg Arg Lys Arg Leu Gly Val Val Lys Asn Val 
    50                  55                  60                  


Leu Ala Ala Ser Thr Gly Val Thr Leu Thr Tyr Gly Val Tyr Leu Gly 
65                  70                  75                  80  


Leu Leu Gln Met Gln Leu Ile Leu His Tyr Asp Glu Thr Tyr Arg Glu 
                85                  90                  95      


Val Lys Tyr Gly Asn Met Gly Leu Pro Asp Ile Asp Ser Lys Met Leu 
            100                 105                 110         


Met Gly Ile Asn Val Thr Pro Ile Ala Ala Leu Leu Tyr Thr Pro Val 
        115                 120                 125             


Leu Ile Arg Phe Phe Gly Thr Lys Trp Met Met Phe Leu Ala Val Gly 
    130                 135                 140                 


Ile Tyr Ala Leu Phe Val Ser Thr Asn Tyr Trp Glu Arg Tyr Tyr Thr 
145                 150                 155                 160 


Leu Val Pro Ser Ala Val Ala Leu Gly Met Ala Ile Val Pro Leu Trp 
                165                 170                 175     


Ala Ser Met Gly Asn Tyr Ile Thr Arg Met Ser Gln Lys Tyr Tyr Glu 
            180                 185                 190         


Tyr Ser His Tyr Lys Glu Gln Asp Glu Gln Gly Pro Gln Gln Arg Pro 
        195                 200                 205             


Pro Arg Gly Ser His Ala Pro Tyr Leu Leu Val Phe Gln Ala Ile Phe 
    210                 215                 220                 


Tyr Ser Phe Phe His Leu Ser Phe Ala Cys Ala Gln Leu Pro Met Ile 
225                 230                 235                 240 


Tyr Phe Leu Asn Asn Tyr Leu Tyr Asp Leu Asn His Thr Leu Ile Asn 
                245                 250                 255     


Val Gln Ser Cys Gly Thr Lys Ser Gln Gly Ile Leu Asn Gly Phe Asn 
            260                 265                 270         


Lys Thr Val Leu Arg Thr Leu Pro Arg Ser Lys Asn Leu Ile Val Val 
        275                 280                 285             


Glu Ser Val Leu Met Ala Val Ala Phe Leu Ala Met Leu Met Val Leu 
    290                 295                 300                 


Gly Leu Cys Gly Ala Ala Tyr Arg Pro Thr Glu Glu Ile Asp Leu Arg 
305                 310                 315                 320 


Ser Val Gly Trp Gly Asn Ile Phe Gln Leu Pro Phe Lys His Val Arg 
                325                 330                 335     


Asp Phe Arg Leu Arg His Leu Val Pro Phe Phe Ile Tyr Ser Gly Phe 
            340                 345                 350         


Glu Val Leu Phe Ala Cys Thr Gly Phe Ala Leu Gly Tyr Gly Val Cys 
        355                 360                 365             


Ser Met Gly Leu Glu Arg Leu Ala Tyr Leu Leu Ile Ala Tyr Ser Leu 
    370                 375                 380                 


Gly Ala Ser Ala Ser Ser Val Leu Gly Leu Leu Gly Leu Trp Leu Pro 
385                 390                 395                 400 


Arg Ser Val Pro Leu Val Ala Gly Ala Gly Leu His Leu Leu Leu Thr 
                405                 410                 415     


Leu Ser Leu Phe Phe Trp Ala Pro Ala Pro Arg Val Leu Gln His Ser 
            420                 425                 430         


Trp Ile Phe Tyr Phe Val Ala Ala Leu Trp Gly Val Gly Ser Ala Leu 
        435                 440                 445             


Asn Lys Thr Gly Leu Ser Thr Leu Leu Gly Ile Leu Tyr Glu Asp Lys 
    450                 455                 460                 


Glu Arg Gln Asp Phe Ile Phe Thr Ile Tyr His Trp Trp Gln Ala Val 
465                 470                 475                 480 


Ala Ile Phe Val Val Tyr Leu Gly Ser Ser Leu Pro Met Lys Ala Lys 
                485                 490                 495     


Leu Ala Val Leu Leu Val Thr Leu Val Ala Ala Ala Ala Ser Tyr Leu 
            500                 505                 510         


Trp Met Glu Gln Lys Leu Gln Gln Gly Leu Val Pro Arg Gln Pro Arg 
        515                 520                 525             


Ile Pro Lys Pro Gln His Lys Val Arg Gly Tyr Arg Tyr Leu Glu Glu 
    530                 535                 540                 


Asp Asn Ser Asp Glu Ser Asp Met Glu Gly Glu Gln Gly Gln Gly Asp 
545                 550                 555                 560 


Cys Ala Glu Asp Glu Ala Pro Gln Ala Gly Pro Leu Gly Ala Glu Pro 
                565                 570                 575     


Ala Gly Pro Cys Arg Lys Pro Cys Pro Tyr Glu Gln Ala Leu Gly Gly 
            580                 585                 590         


Asp Gly Pro Glu Glu Gln 
        595             


<210>  2
<211>  597
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Ala Glu Pro Pro Leu Tyr Pro Met Ala Gly Ala Ala Gly Pro 
1               5                   10                  15      


Gln Gly Asp Glu Asp Leu Leu Gly Val Pro Asp Gly Pro Glu Ala Pro 
            20                  25                  30          


Leu Asp Glu Leu Val Gly Ala Tyr Pro Asn Tyr Asn Glu Glu Glu Glu 
        35                  40                  45              


Glu Arg Arg Tyr Tyr Arg Arg Lys Arg Leu Gly Val Leu Lys Asn Val 
    50                  55                  60                  


Leu Ala Ala Ser Ala Gly Gly Met Leu Thr Tyr Gly Val Tyr Leu Gly 
65                  70                  75                  80  


Leu Leu Gln Met Gln Leu Ile Leu His Tyr Asp Glu Thr Tyr Arg Glu 
                85                  90                  95      


Val Lys Tyr Gly Asn Met Gly Leu Pro Asp Ile Asp Ser Lys Met Leu 
            100                 105                 110         


Met Gly Ile Asn Val Thr Pro Ile Ala Ala Leu Leu Tyr Thr Pro Val 
        115                 120                 125             


Leu Ile Arg Phe Phe Gly Thr Lys Trp Met Met Phe Leu Ala Val Gly 
    130                 135                 140                 


Ile Tyr Ala Leu Phe Val Ser Thr Asn Tyr Trp Glu Arg Tyr Tyr Thr 
145                 150                 155                 160 


Leu Val Pro Ser Ala Val Ala Leu Gly Met Ala Ile Val Pro Leu Trp 
                165                 170                 175     


Ala Ser Met Gly Asn Tyr Ile Thr Arg Met Ala Gln Lys Tyr His Glu 
            180                 185                 190         


Tyr Ser His Tyr Lys Glu Gln Asp Gly Gln Gly Met Lys Gln Arg Pro 
        195                 200                 205             


Pro Arg Gly Ser His Ala Pro Tyr Leu Leu Val Phe Gln Ala Ile Phe 
    210                 215                 220                 


Tyr Ser Phe Phe His Leu Ser Phe Ala Cys Ala Gln Leu Pro Met Ile 
225                 230                 235                 240 


Tyr Phe Leu Asn His Tyr Leu Tyr Asp Leu Asn His Thr Leu Tyr Asn 
                245                 250                 255     


Val Gln Ser Cys Gly Thr Asn Ser His Gly Ile Leu Ser Gly Phe Asn 
            260                 265                 270         


Lys Thr Val Leu Arg Thr Leu Pro Arg Ser Gly Asn Leu Ile Val Val 
        275                 280                 285             


Glu Ser Val Leu Met Ala Val Ala Phe Leu Ala Met Leu Leu Val Leu 
    290                 295                 300                 


Gly Leu Cys Gly Ala Ala Tyr Arg Pro Thr Glu Glu Ile Asp Leu Arg 
305                 310                 315                 320 


Ser Val Gly Trp Gly Asn Ile Phe Gln Leu Pro Phe Lys His Val Arg 
                325                 330                 335     


Asp Tyr Arg Leu Arg His Leu Val Pro Phe Phe Ile Tyr Ser Gly Phe 
            340                 345                 350         


Glu Val Leu Phe Ala Cys Thr Gly Ile Ala Leu Gly Tyr Gly Val Cys 
        355                 360                 365             


Ser Val Gly Leu Glu Arg Leu Ala Tyr Leu Leu Val Ala Tyr Ser Leu 
    370                 375                 380                 


Gly Ala Ser Ala Ala Ser Leu Leu Gly Leu Leu Gly Leu Trp Leu Pro 
385                 390                 395                 400 


Arg Pro Val Pro Leu Val Ala Gly Ala Gly Val His Leu Leu Leu Thr 
                405                 410                 415     


Phe Ile Leu Phe Phe Trp Ala Pro Val Pro Arg Val Leu Gln His Ser 
            420                 425                 430         


Trp Ile Leu Tyr Val Ala Ala Ala Leu Trp Gly Val Gly Ser Ala Leu 
        435                 440                 445             


Asn Lys Thr Gly Leu Ser Thr Leu Leu Gly Ile Leu Tyr Glu Asp Lys 
    450                 455                 460                 


Glu Arg Gln Asp Phe Ile Phe Thr Ile Tyr His Trp Trp Gln Ala Val 
465                 470                 475                 480 


Ala Ile Phe Thr Val Tyr Leu Gly Ser Ser Leu His Met Lys Ala Lys 
                485                 490                 495     


Leu Ala Val Leu Leu Val Thr Leu Val Ala Ala Ala Val Ser Tyr Leu 
            500                 505                 510         


Arg Met Glu Gln Lys Leu Arg Arg Gly Val Ala Pro Arg Gln Pro Arg 
        515                 520                 525             


Ile Pro Arg Pro Gln His Lys Val Arg Gly Tyr Arg Tyr Leu Glu Glu 
    530                 535                 540                 


Asp Asn Ser Asp Glu Ser Asp Ala Glu Gly Glu His Gly Asp Gly Ala 
545                 550                 555                 560 


Glu Glu Glu Ala Pro Pro Ala Gly Pro Arg Pro Gly Pro Glu Pro Ala 
                565                 570                 575     


Gly Leu Gly Arg Arg Pro Cys Pro Tyr Glu Gln Ala Gln Gly Gly Asp 
            580                 585                 590         


Gly Pro Glu Glu Gln 
        595         


<210>  3
<211>  623
<212>  PRT
<213>  Danio rerio

<400>  3

Met Ala Ala Leu Ile Ala Asp Asp Asn Val Tyr Arg Glu Ala Glu Leu 
1               5                   10                  15      


Asp Gly Ala Pro Pro Ala Glu Ala Glu Asp Pro Pro Gln Leu Pro Gly 
            20                  25                  30          


Pro Glu Gly Asn Ile Gln Gly Gln Val Glu Glu Phe Leu Gly Pro His 
        35                  40                  45              


Pro Asp Tyr Asp Glu Glu Glu Glu Glu Arg Lys Tyr Tyr Arg Arg Lys 
    50                  55                  60                  


Arg Leu Gly Val Val Lys Asn Val Val Gly Ala Ser Cys Gly Gly Met 
65                  70                  75                  80  


Ile Ile Tyr Ser Val Tyr Met Gly Leu Leu Gln Met Gln Leu Ile Leu 
                85                  90                  95      


His Tyr Asp Glu Thr Tyr Arg Glu Val Lys Tyr Gly Thr Leu Gly Leu 
            100                 105                 110         


Glu Asp Ile Asp Asn Lys Met Leu Met Gly Ile Asn Val Thr Pro Ile 
        115                 120                 125             


Val Gly Leu Leu Tyr Thr Pro Val Leu Ile Arg Phe Leu Gly Thr Lys 
    130                 135                 140                 


Trp Met Met Phe Leu Ala Ser Gly Ile Tyr Ala Leu Phe Val Ser Thr 
145                 150                 155                 160 


Asn Tyr Trp Glu Arg Tyr Tyr Thr Leu Val Pro Ser Ala Val Ala Ile 
                165                 170                 175     


Gly Val Val Ile Val Pro Leu Trp Ala Ser Met Gly Asn Tyr Ile Thr 
            180                 185                 190         


Arg Met Ala Gln Gln Tyr Tyr Glu Phe Val Asn Tyr Lys Asp Glu Asn 
        195                 200                 205             


Val Gln Glu Gln Lys Lys Pro Pro Lys Gly Ala Phe His Ser Tyr Ile 
    210                 215                 220                 


Ile Ile Phe Gln Ser Val Phe Tyr Ile Ile Phe His Leu Ser Phe Val 
225                 230                 235                 240 


Phe Ala Glu Phe Pro Thr Val Leu Phe Leu Asn Asn Tyr Leu Asn Asp 
                245                 250                 255     


Tyr Arg His Thr Leu Phe Lys Val Ser Gln Cys Gly Ala Gly Gly Lys 
            260                 265                 270         


Gly Val Ile Glu Asn Phe Asn Lys Thr Val Leu Lys Ser Leu Pro Arg 
        275                 280                 285             


Ser Leu Leu Leu Ile Glu Val Glu Ser Ala Leu Met Gly Ala Ala Phe 
    290                 295                 300                 


Leu Ser Met Leu Ile Phe Leu Leu Leu Cys Gly Ala Ala Tyr Arg Pro 
305                 310                 315                 320 


Thr Glu Glu Ile Asp Leu Arg Ser Ile Gly Trp Gly Asn Ile Phe Gln 
                325                 330                 335     


Leu Pro Phe Lys His Leu Arg Asp Tyr Arg Ile Arg Leu Leu Cys Pro 
            340                 345                 350         


Phe Phe Ile Tyr Ser Gly Phe Glu Val Leu Phe Ala Val Gln Gly Leu 
        355                 360                 365             


Thr Leu Ser Tyr Gly Val Cys Ala Val Gly Met Glu Lys Leu Trp Leu 
    370                 375                 380                 


Leu Val Met Val Tyr Gly Leu Ser Ser Ser Ile Cys Ser Ala Leu Ala 
385                 390                 395                 400 


Leu Ala Leu Leu Arg Leu Pro Arg Pro Val Ile Leu Leu Ala Gly Ala 
                405                 410                 415     


Phe Val His Phe Val Leu Ile Ile Ala Leu Met Cys Trp Ser Pro Thr 
            420                 425                 430         


Pro Arg Asp Thr Ser Arg Leu Pro Tyr Leu Leu Val Val Ser Ala Leu 
        435                 440                 445             


Trp Gly Leu Gly Thr Ala Leu Asn Lys Thr Gly Leu Ser Thr Leu Leu 
    450                 455                 460                 


Gly Met Leu Tyr Glu Asp Lys Glu Arg Leu Asp Phe Val Tyr Thr Ile 
465                 470                 475                 480 


Tyr His Trp Trp Gln Ala Ile Ala Ile Phe Ile Val Tyr Leu Trp Ser 
                485                 490                 495     


Ala Leu Pro Met Arg Ala Lys Leu Gly Leu Leu Leu Leu Thr Leu Leu 
            500                 505                 510         


Val Ala Ser Leu Cys Tyr Val Gln Met Glu Arg Arg Leu Ala Lys Lys 
        515                 520                 525             


Ile Pro Phe Arg Leu Pro Arg Ile Pro Arg Pro Arg His Lys Val Lys 
    530                 535                 540                 


Gly Tyr Arg Tyr Leu Glu Glu Glu Asn Ser Asp Glu Ser Asp Thr Asp 
545                 550                 555                 560 


Leu Ser Asp Ala Asp Asp Asp Asp Asp Lys Glu Glu Asp Glu Arg Met 
                565                 570                 575     


Leu Val Glu Glu Asp Arg Asn Thr Asp Gly Asp Ser Gln Gly Ser Pro 
            580                 585                 590         


Gly Pro Glu Arg Lys Arg Val Arg Asp Arg Arg Arg Lys His Asp Asn 
        595                 600                 605             


Thr Ala Tyr Glu Gln Ala Gly Glu Arg Asp Asp Tyr Val Gln His 
    610                 615                 620             


<210>  4
<211>  568
<212>  PRT
<213>  Columba livia

<400>  4

Met Glu Lys Asp Pro Asn Tyr Leu Gln Glu Ala Ala Lys Gly Leu Ala 
1               5                   10                  15      


Gly Asp Arg Leu Gly Ala Glu Gly Thr Glu Ala Gln Leu Asp Asp Phe 
            20                  25                  30          


Val Gly Ala Gln Ser Asp Tyr Asn Glu Glu Glu Glu Glu Gln Lys Tyr 
        35                  40                  45              


Phe Arg Arg Lys Arg Leu Gly Ile Val Lys Asn Val Val Ala Ala Ser 
    50                  55                  60                  


Leu Ala Gly Met Leu Thr Tyr Gly Val Tyr Leu Gly Leu Leu Gln Met 
65                  70                  75                  80  


Gln Leu Ile Leu His Tyr Asp Glu Thr Tyr Arg Glu Val Lys Tyr Ser 
                85                  90                  95      


Asn Ile Gln Leu Glu Asp Ile Asp Arg Lys Val Leu Met Gly Ile Asn 
            100                 105                 110         


Val Thr Pro Ile Ala Ala Leu Leu Tyr Thr Pro Val Leu Ile Arg Phe 
        115                 120                 125             


Phe Gly Thr Lys Trp Ala Met Phe Leu Ala Val Gly Ile Tyr Ala Leu 
    130                 135                 140                 


Phe Val Ser Ser Asn Tyr Trp Glu Arg Tyr Tyr Thr Leu Val Pro Ser 
145                 150                 155                 160 


Ala Val Ala Ile Gly Val Ala Ile Val Pro Leu Trp Ala Ser Met Gly 
                165                 170                 175     


Asn Tyr Ile Met Arg Met Ala Gln Lys Tyr Tyr Glu Tyr Val Asn Tyr 
            180                 185                 190         


Lys Glu Asp His Val Gln Glu Gln Gln Arg Pro Pro Arg Gly Ala Cys 
        195                 200                 205             


Asn Thr Tyr Ile Ile Val Phe Gln Thr Val Phe Tyr Ala Cys Phe His 
    210                 215                 220                 


Leu Ser Phe Val Cys Ala Gln Met Pro Met Leu Phe Phe Leu Asn Asn 
225                 230                 235                 240 


Tyr Leu Tyr Gln Leu Asn His Thr Leu Tyr Asn Ile Lys His Cys Gly 
                245                 250                 255     


Thr Leu Ser His Gly Thr Leu Ser Gly Phe Asn Thr Thr Val Leu Gln 
            260                 265                 270         


Ser Leu Pro Arg Ser Val Asn Leu Ile Ile Val Glu Ser Ala Leu Met 
        275                 280                 285             


Ala Ala Ala Phe Leu Ala Met Leu Thr Val Leu Val Leu Cys Gly Ser 
    290                 295                 300                 


Ala Tyr Gln Pro Met Glu Glu Ile Asp Leu Arg Ser Ile Gly Trp Gly 
305                 310                 315                 320 


Asn Ile Phe Gln Leu Pro Phe Lys His Met Arg Asp Tyr Arg Leu Arg 
                325                 330                 335     


His Leu Phe Pro Leu Phe Ile Tyr Ser Gly Phe Glu Glu Leu Phe Val 
            340                 345                 350         


Cys Thr Gly Phe Ser Leu Asn Tyr Gly Val Cys Ala Leu Gly Leu Glu 
        355                 360                 365             


Lys Leu Ala Tyr Leu Leu Met Ala Tyr Gly Phe Ser Ala Ser Leu Cys 
    370                 375                 380                 


Ser Ser Leu Ala Leu Ser Met Leu Arg Leu Arg Arg Gln Ile Pro Leu 
385                 390                 395                 400 


Leu Ala Gly Ala Phe Ile His Ala Ala Leu Leu Val Thr Leu Phe Cys 
                405                 410                 415     


Trp Ala Pro Gln Pro Arg Leu Val Val Gln Ala Pro Leu Leu Tyr Thr 
            420                 425                 430         


Ile Ala Val Leu Trp Gly Thr Gly Ser Ala Leu Asn Lys Thr Ser Ile 
        435                 440                 445             


Ser Ile Leu Leu Gly Met Leu Tyr Glu Asp Lys Glu Arg Gln Asp Phe 
    450                 455                 460                 


Ile Phe Thr Ile Tyr His Trp Trp Gln Ala Leu Ala Ile Phe Thr Val 
465                 470                 475                 480 


Tyr Leu Trp Ser Glu Leu Pro Met Lys Ala Lys Leu Ser Ile Met Leu 
                485                 490                 495     


Ala Thr Leu Ala Val Ala Thr Gly Ala Tyr Leu Trp Met Glu His Lys 
            500                 505                 510         


Leu Ala Gln His Val Ala Tyr Arg Leu Pro Arg Ile Pro Arg Pro Arg 
        515                 520                 525             


Leu Arg Met His Gly Tyr Cys Tyr Leu Glu Glu Asp Asp Ser Asp Glu 
    530                 535                 540                 


Thr Gly Ser Glu Arg Arg Pro Thr Glu Ser Ala Ser Arg Asp Glu Leu 
545                 550                 555                 560 


Pro Glu Asp Glu Asn Gln Leu Gly 
                565             


<210>  5
<211>  595
<212>  PRT
<213>  Xenopus tropicalis

<400>  5

Met Ala Asp Ile Tyr Pro Glu Ala Ser Ile Asn Gly Ile Ala Ala Asp 
1               5                   10                  15      


Arg Gly Arg Asn Tyr Ala Val Gln Asp Asp Thr Pro Val Leu Asp Gly 
            20                  25                  30          


Ala Asn Ala Gln Val Glu Asp Phe Leu Gly Glu Lys Pro Asp Tyr Asp 
        35                  40                  45              


Glu Glu Ala Glu Glu Lys Arg Tyr Tyr Arg Arg Lys Arg Leu Leu Thr 
    50                  55                  60                  


Val Lys Ser Val Val Phe Ala Ser Leu Gly Ala Ala Leu Thr Tyr Gly 
65                  70                  75                  80  


Val Tyr Leu Gly Leu Leu Gln Met Gln Leu Ile Leu His Tyr Asp Glu 
                85                  90                  95      


Thr Tyr Arg Asp Val Lys Tyr Ser Asn Ile Gly Leu Gln Asp Ile Asp 
            100                 105                 110         


Ser Lys Met Leu Met Gly Ile Asn Val Thr Pro Ile Val Ala Leu Leu 
        115                 120                 125             


Tyr Thr Pro Val Leu Ile Arg Phe Phe Gly Thr Lys Trp Met Met Phe 
    130                 135                 140                 


Leu Ser Ser Gly Ile Tyr Ala Leu Phe Val Ser Thr Asn Tyr Trp Glu 
145                 150                 155                 160 


Arg Tyr Tyr Thr Leu Val Pro Ser Ala Thr Val Ile Gly Val Met Ile 
                165                 170                 175     


Val Pro Phe Trp Ala Ser Leu Gly Asn Tyr Ile Thr Arg Met Ala Gln 
            180                 185                 190         


Lys Tyr Tyr Glu Phe Val Asn Tyr Lys Glu Glu Asn Val Arg Glu Gln 
        195                 200                 205             


Arg Arg Val Pro Arg Gly Ala Ser His Arg Tyr Ile Ile Ile Phe Gln 
    210                 215                 220                 


Ser Ile Phe Tyr Ser Leu Phe His Ile Ser Phe Val Leu Ala Gln Leu 
225                 230                 235                 240 


Pro Val His Phe Phe Leu Ser Lys Phe Phe Tyr Ser Tyr Asn His Thr 
                245                 250                 255     


Leu Phe Asn Val Arg Asp Cys Gly Ala Ala Ile Gln His Gly Ile Leu 
            260                 265                 270         


Pro Asn Phe Asn Leu Thr Val Leu His Thr Leu Pro Pro Ser Leu Asn 
        275                 280                 285             


Leu Ile Tyr Val Glu Ser Ala Leu Met Gly Ala Ala Leu Val Ser Met 
    290                 295                 300                 


Leu Leu Ile Leu Leu Leu Cys Gly Ser Ala Tyr Arg Pro Thr Glu Glu 
305                 310                 315                 320 


Ile Asp Leu Arg Ser Ile Gly Trp Gly Asn Ile Phe Gln Leu Pro Phe 
                325                 330                 335     


Lys His Ala Arg Asp Tyr Arg Leu Arg Cys Leu Ala Pro Tyr Phe Leu 
            340                 345                 350         


Tyr Ser Gly Phe Glu Val Leu Phe Ala Cys Thr Cys Phe Ala Leu Cys 
        355                 360                 365             


Tyr Gly Val Cys Ser Leu Gly Leu Glu Ser Leu Pro Phe Leu Leu Thr 
    370                 375                 380                 


Ala Tyr Gly Ile Ser Ala Ser Phe Ser Ser Ser Leu Ala Leu Cys Met 
385                 390                 395                 400 


Leu Arg Phe Pro Arg Gln Ile Pro Leu Val Gly Gly Thr Leu Leu His 
                405                 410                 415     


Cys Cys Ile Leu Ile Gly Leu Phe Phe Trp Ser Pro Thr Pro Lys Leu 
            420                 425                 430         


Gln Ser Gln Lys Pro Leu Leu Tyr Leu Val Ala Ile Leu Trp Gly Val 
        435                 440                 445             


Gly Ser Ala Leu Asn Lys Ser Gly Leu Ser Ile Ile Ile Gly Val Phe 
    450                 455                 460                 


Tyr Glu Asp Lys Glu Arg Gln Asp Phe Val Phe Thr Ile Tyr His Trp 
465                 470                 475                 480 


Leu Gln Ala Leu Ala Ile Phe Ile Val Tyr Leu Trp Ser Gly Ile Pro 
                485                 490                 495     


Val Thr Ala Lys Leu Gly Ile Met Leu Ala Ser Ala Leu Ile Ser Val 
            500                 505                 510         


Leu Ser Tyr Leu Trp Met Glu His Lys Leu Ser Cys Lys Val Pro Tyr 
        515                 520                 525             


Arg Val Pro Lys Ile Pro Ala Pro Arg His Lys Val Lys Gly Tyr Arg 
    530                 535                 540                 


Tyr Met Glu Glu Glu Asn Ser Asp Glu Ser Gly Ser Glu Gly Glu Lys 
545                 550                 555                 560 


Glu Gln Ser Glu Gly Gly Glu Ser Glu Glu Glu Asp Lys Thr Val Pro 
                565                 570                 575     


Cys Tyr Arg Gln Pro Gly Arg Lys Glu Cys Tyr Glu Gln Ala Val Gly 
            580                 585                 590         


Asp Glu Glu 
        595 


<210>  6
<211>  570
<212>  PRT
<213>  Callorhinchus milii

<400>  6

Met Glu Asn Asp Arg Asp Ala Thr Glu Thr Gly Asn Val Ile Arg Asn 
1               5                   10                  15      


Ser Ser Pro Ala Glu Ile Leu Glu Asp Arg Ser Thr Glu Ile Asp Asp 
            20                  25                  30          


Phe Ile Gly Pro Asn Leu Glu Tyr Asp Ala Glu Ile Glu Glu Glu Arg 
        35                  40                  45              


His Phe Trp Arg Lys Arg Val Ala Val Val Lys Asn Leu Val Cys Val 
    50                  55                  60                  


Ser Val Ala Cys Met Leu Thr Tyr Gly Ile Tyr Leu Gly Leu Leu Gln 
65                  70                  75                  80  


Met Gln Leu Ile Leu His Tyr Asp Glu Thr Tyr Arg Glu Val Lys Tyr 
                85                  90                  95      


Gly Asn Met Gly Leu Gln Asp Ile Asp Gln Lys Met Leu Met Gly Ile 
            100                 105                 110         


Asn Val Thr Pro Val Val Ala Leu Leu Tyr Thr Pro Val Leu Ile Arg 
        115                 120                 125             


Phe Leu Gly Thr Lys Trp Leu Leu Phe Leu Cys Val Gly Val Tyr Ala 
    130                 135                 140                 


Leu Phe Val Ser Thr Asn Tyr Trp Glu Arg Tyr Tyr Thr Leu Val Pro 
145                 150                 155                 160 


Ser Ala Ile Ala Ile Gly Phe Ser Ile Val Pro Leu Trp Thr Ser Ile 
                165                 170                 175     


Gly Asn Tyr Ile Thr Arg Met Ala Gln Lys Tyr Tyr Glu Tyr Ser Asn 
            180                 185                 190         


Tyr Lys Ala Ile Asp Val Gln Gln Gln Lys Lys Ala Pro Lys Gly Ala 
        195                 200                 205             


Tyr Glu Lys Tyr Ile Val Ile Phe His Ser Val Phe Tyr Ala Ile Phe 
    210                 215                 220                 


Ser Leu Ser Leu Val Cys Ala Glu Leu Pro Met Ile Cys Phe Leu Thr 
225                 230                 235                 240 


Asp Tyr Leu Tyr Pro Tyr Asp His Thr Leu Tyr Asn Val Lys His Cys 
                245                 250                 255     


Gly Pro Gln Met Lys Gly Cys Leu Glu Gly Leu Asn Lys Thr Val Leu 
            260                 265                 270         


Ile Lys Leu Pro Arg Ser Thr Ser Leu Ile Ile Val Glu Ser Val Met 
        275                 280                 285             


Met Gly Val Ala Phe Leu Ser Met Leu Leu Val Leu Met Leu Cys Gly 
    290                 295                 300                 


Ala Ala Tyr Arg Pro Thr Glu Glu Ile Asp Leu Arg Ser Ile Gly Trp 
305                 310                 315                 320 


Gly Asn Ile Phe Gln Leu Pro Phe Lys His Leu Arg Asp Phe Arg Leu 
                325                 330                 335     


Arg Leu Leu Ile Pro Phe Phe Val Phe Ser Gly Leu Glu Met Val Phe 
            340                 345                 350         


Ala Cys Thr Gly Phe Ala Leu Ser Tyr Gly Val Cys Ser Leu Gly Leu 
        355                 360                 365             


Glu Arg Leu Ser Ser Leu Ile Met Val Tyr Gly Leu Ser Trp Ser Leu 
    370                 375                 380                 


Trp Ser Leu Leu Ser Leu Ser Leu Pro Arg Arg Gly Ile Leu Val Ala 
385                 390                 395                 400 


Gly Gly Val Leu His Leu Thr Leu Leu Leu Thr Leu Met Val Trp Ala 
                405                 410                 415     


Pro Ala Pro Arg Lys Pro Thr Thr Gly Asn Met Val Thr Leu His Ile 
            420                 425                 430         


Ile Ala Gly Leu Trp Gly Leu Gly Thr Ala Phe Asn Lys Ser Gly Leu 
        435                 440                 445             


Ser Ala Leu Leu Gly Ile Leu Tyr Ser Asp Lys Gly Arg Gln Asp Phe 
    450                 455                 460                 


Ile Phe Ala Val Tyr His Trp Cys Gln Ser Met Ala Ile Phe Gly Tyr 
465                 470                 475                 480 


Tyr Leu Leu Ser Asn Leu Gln Met Gln Val Lys Leu Ser Ile Leu Leu 
                485                 490                 495     


Ile Cys Leu Val Ile Ser Leu Leu Ser Phe Gly Trp Met Glu Arg Lys 
            500                 505                 510         


Ile Lys Arg Gln Val Pro Tyr Arg Ile Pro Arg Ile Pro Lys Pro Arg 
        515                 520                 525             


His Lys Thr Lys Gly Tyr Arg Tyr Leu Glu Glu Glu Asn Ser Asp Glu 
    530                 535                 540                 


Glu Glu Asp Gly Ala Glu Glu Lys Glu Met Glu Gln Asp Gly Gly Glu 
545                 550                 555                 560 


Asp Glu Arg Glu Thr Leu Arg Arg Arg Asp 
                565                 570 


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized phospho-peptide

<400>  7

Tyr Leu Glu Glu Asp Asn Ser Asp Glu Ser Asp Met Glu Gly Glu Gln 
1               5                   10                  15      


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG-B

<400>  8
tccatgacgt tcctgatgct                                                   20


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  9
tgctgtggct tcggaatgcg cgg                                               23


<210>  10
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3xFLAG peptide

<400>  10

Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys 
            20          


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA peptide

<400>  11

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  12
ctcacctacg gcgtctacc                                                    19


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  13
ggcgcttgcg gcggtagtag cgg                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  14
cggagtggtc aagaacgtgc tgg                                               23


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  15
ttcggaatgc gcggctgccg cgg                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  16
agtccgcggc taccgctacc tgg                                               23


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  17
ggttcaagaa cagcgatagg                                                   20


