                         SEQUENCE LISTING

<110>  Pfizer Inc.
       Owen, Dafydd
       Pettersson, Martin
       Reese, Matthew
       Sammons, Matthew
       Tuttle, Jamison
       Yang, Qingyi
       Yang, Xiaojing
       Verhoest, Patrick
 
<120>  Nitrile-Containing Antiviral Compounds

<130>  PC072660A

<150>  US 63/073,982
<151>  2020-09-03

<150>  US 63/143,435
<151>  2021-01-29

<150>  US 63/170,158
<151>  2021-04-02

<150>  US 63/194,241
<151>  2021-05-28

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Gly Phe Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Phe Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Phe 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn Phe Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu 
        195                 200                 205             


Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Phe Thr 
    210                 215                 220                 


Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu 
225                 230                 235                 240 


Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln 
                245                 250                 255     


Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu 
            260                 265                 270         


Gln Asn Gly Met Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr 
    290                 295                 300                 


Phe Gln 
305     


<210>  2
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Gly Phe Arg Lys Met Ala Phe Pro Ser Gly Lys Val Glu Gly Cys 
1               5                   10                  15      


Met Val Gln Val Thr Cys Gly Thr Thr Thr Leu Asn Gly Leu Trp Leu 
            20                  25                  30          


Asp Asp Val Val Tyr Cys Pro Arg His Val Ile Cys Thr Ser Glu Asp 
        35                  40                  45              


Met Leu Asn Pro Asn Tyr Glu Asp Leu Leu Ile Arg Lys Ser Asn His 
    50                  55                  60                  


Asn Phe Leu Val Gln Ala Gly Asn Val Gln Leu Arg Val Ile Gly His 
65                  70                  75                  80  


Ser Met Gln Asn Cys Val Leu Lys Leu Lys Val Asp Thr Ala Asn Pro 
                85                  90                  95      


Lys Thr Pro Lys Tyr Lys Phe Val Arg Ile Gln Pro Gly Gln Thr Phe 
            100                 105                 110         


Ser Val Leu Ala Cys Tyr Asn Gly Ser Pro Ser Gly Val Tyr Gln Cys 
        115                 120                 125             


Ala Met Arg Pro Asn Phe Thr Ile Lys Gly Ser Phe Leu Asn Gly Ser 
    130                 135                 140                 


Cys Gly Ser Val Gly Phe Asn Ile Asp Tyr Asp Cys Val Ser Phe Cys 
145                 150                 155                 160 


Tyr Met His His Met Glu Leu Pro Thr Gly Val His Ala Gly Thr Asp 
                165                 170                 175     


Leu Glu Gly Asn Phe Tyr Gly Pro Phe Val Asp Arg Gln Thr Ala Gln 
            180                 185                 190         


Ala Ala Gly Thr Asp Thr Thr Ile Thr Val Asn Val Leu Ala Trp Leu 
        195                 200                 205             


Tyr Ala Ala Val Ile Asn Gly Asp Arg Trp Phe Leu Asn Arg Phe Thr 
    210                 215                 220                 


Thr Thr Leu Asn Asp Phe Asn Leu Val Ala Met Lys Tyr Asn Tyr Glu 
225                 230                 235                 240 


Pro Leu Thr Gln Asp His Val Asp Ile Leu Gly Pro Leu Ser Ala Gln 
                245                 250                 255     


Thr Gly Ile Ala Val Leu Asp Met Cys Ala Ser Leu Lys Glu Leu Leu 
            260                 265                 270         


Gln Asn Gly Met Asn Gly Arg Thr Ile Leu Gly Ser Ala Leu Leu Glu 
        275                 280                 285             


Asp Glu Phe Thr Pro Phe Asp Val Val Arg Gln Cys Ser Gly Val Thr 
    290                 295                 300                 


Phe Gln 
305     


