                         SEQUENCE LISTING

<110>  Erber Aktiengesellschaft
 
<120>  IMPROVED POLYPEPTIDES CAPABLE OF CONVERTING SUBSTRATE 3-KETO- 
       DEOXYNIVALENOL INTO 3-EPI- DEOXYNIVALENOL

<130>  ERB17006PCT

<150>  EP20178702
<151>  2020-06-08

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  1

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser His Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Lys Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


His Leu Leu Leu Asp Asp Tyr Val Ala Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Thr Gly Val Ser Glu Thr Ile Ile Gly Asn 
    50                  55                  60                  


Trp Leu Lys Ala Lys Pro Gly Arg Glu Leu Asn Leu Val Ile Ala Ser 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Asn Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Gly Ala Ala Leu Asp Ala Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu Arg Ile Asp Leu Tyr Gln Met His Ala Phe Asp Ala Leu Thr 
        115                 120                 125             


Pro Met Asp Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Arg Asn Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Phe Thr Gly Trp Gln Leu Thr 
145                 150                 155                 160 


Lys Ala Val Tyr Leu Ala Lys Leu Asn Gly Tyr Gln Pro Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Ser Leu Asp Ala Gln Ile Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Ala Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala 
225                 230                 235                 240 


Phe Glu Ala Arg Asn Ala Lys Asp Ala Thr Trp Ser Ile Ile Gly Ala 
                245                 250                 255     


Val Glu Asp Ile Ala Lys Ala His Asn Val Ser Met Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Val Ala Gln Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Lys Ser Val Ser Leu 
    290                 295                 300                 


Lys Leu Ser Ala Ala Asp Leu Ala Thr Leu Ser Glu Ala Ser Lys Pro 
305                 310                 315                 320 


Ala Met Ser Asp Tyr Pro Tyr Gly Ala Gly Gly Ile Asn Gln Arg His 
                325                 330                 335     


Arg Lys Leu Glu Gly Gly Arg 
            340             


<210>  2
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  2

Met Glu Tyr Arg Lys Leu Gly Asn Ser Gly Thr Ile Val Thr Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Thr Thr Ser 
            20                  25                  30          


His Leu Ile Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Val Ser Glu Glu Ile Val Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Arg Pro Glu Ala Ala Ser Gln Val Val Leu Ala Thr 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Ile Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Glu Asp Ser Leu Arg Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Val Thr 
145                 150                 155                 160 


Lys Ala Val His Val Ala Lys Ala Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ala Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ser 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Glu Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Glu Ile Ala Lys Asp Arg Gly Ala Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Ser Lys Val 
    290                 295                 300                 


Lys Leu Ser Ala Glu Glu Thr Asp Lys Leu Thr Arg Ile Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Val Ser Gln Arg Phe 
                325                 330                 335     


Arg Lys Met Glu Gly Gly Arg 
            340             


<210>  3
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  3

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Asn Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Asp Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Val Leu Met Asp Gln Tyr Val Glu Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Ala Gly Leu Ser Glu Glu Ile Val Gly Arg 
    50                  55                  60                  


Trp Leu Lys Gly Lys Lys Leu Arg Asp Leu Val Ile Ala Thr Lys Gly 
65                  70                  75                  80  


Arg Phe Pro Met Gly Gln Gly Pro Asn His Leu Gly Leu Ser Arg Lys 
                85                  90                  95      


His Leu Gly Glu Ala Leu Asp Ala Ser Leu Gln Arg Leu Gly Val Glu 
            100                 105                 110         


Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro Leu 
        115                 120                 125             


Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Arg Ser Gly Lys Ile 
    130                 135                 140                 


Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp His Ile Thr Lys Ala 
145                 150                 155                 160 


Val Trp Met Ala Arg Ala Gln Gly Tyr Ala Ala Pro Val Thr Leu Gln 
                165                 170                 175     


Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Val Val Pro 
            180                 185                 190         


Ala Cys Glu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro Glu Gly 
    210                 215                 220                 


Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala Tyr Glu 
225                 230                 235                 240 


Gly Arg Asn Ala Gln Glu Arg Thr Trp Ala Ile Ile Gly Ala Val Glu 
                245                 250                 255     


Asp Ile Ala Lys Ala Gln Asp Val Thr Met Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Thr Ala Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly Ala Arg 
        275                 280                 285             


Thr Ala Glu Gln Leu Lys Asp Asn Leu Gly Ala Ala Asp Leu Val Leu 
    290                 295                 300                 


Ser Glu Ala Asp Met Glu Arg Leu Asn Ala Val Ser Ala Pro Gln Met 
305                 310                 315                 320 


Ala Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Gly Gln Arg Asn Arg Lys 
                325                 330                 335     


Ile Glu Gly Gly Arg 
            340     


<210>  4
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  4

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser His Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ser Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Lys Leu Leu Asp Asp Tyr Val Ala Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Ala Gly Val Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Asp Lys Pro Gly Arg Ala Gln Asn Leu Val Ile Ala Thr 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Gln Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Gly Ala Ala Leu Asp Ala Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Phe Asp Val Leu Thr 
        115                 120                 125             


Pro Leu Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Arg Asn Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Phe Thr Gly Trp Gln Leu Thr 
145                 150                 155                 160 


Lys Ala Val Trp Leu Ala Lys Leu Asn Gly Tyr Gln Pro Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Ser Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Ser Leu Asp Ala Gly Ile Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro 
    210                 215                 220                 


Thr Gly Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala 
225                 230                 235                 240 


Phe Glu Ala Arg Asn Ala Lys Asp Ser Thr Trp Ala Val Ile Gly Ala 
                245                 250                 255     


Val Glu Asp Ile Ala Lys Ala Arg Gly Val Ser Met Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Ala Ala Gln Pro Ala Val Ala Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Gln Glu Gln Leu Ala Asp Asn Leu Lys Ser Ala Ala Leu 
    290                 295                 300                 


Lys Leu Ser Ala Gly Asp Leu Gln Thr Leu Gly Asp Val Ser Lys Pro 
305                 310                 315                 320 


Val Met Ala Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Asn Gln Arg Asn 
                325                 330                 335     


Arg Asn Ile Glu Gly Gly Arg 
            340             


<210>  5
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  5

Met Lys Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Ala Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ser Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Arg Leu Met Asp Asp Tyr Val Ala Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Ala Gly Val Ser Glu Glu Ile Val Gly Arg 
    50                  55                  60                  


Trp Leu Lys Thr Lys Pro Thr Gly Leu Arg Asp Leu Val Ile Thr Thr 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Asp Gly Pro Asn His Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys Asn Leu Arg Glu Ala Leu Asp Ala Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu His Ile Asp Leu Tyr Gln Met His Ala Phe Asp Ala Leu Thr 
        115                 120                 125             


Pro Leu Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Arg Asn Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp Gln Leu Thr 
145                 150                 155                 160 


Lys Ala Val Trp Ile Ala Arg Ala Asn Gly Tyr Gln Pro Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Ser Leu Asp Ala Gly Ile Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ser Gly Lys Tyr Arg Arg Asp Glu Met Pro 
    210                 215                 220                 


Thr Gly Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Gly Glu Ala 
225                 230                 235                 240 


Tyr Glu Arg Arg Asn Ala Lys Ser Ala Thr Trp Asp Ile Ile Gly Val 
                245                 250                 255     


Val Glu Asp Val Ala Lys Thr Arg Gly Val Ser Met Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Ala Gln Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Thr Glu Gln Leu Lys Asp Asn Leu Gly Ala Ile Asp Leu 
    290                 295                 300                 


Ala Leu Ser Thr Glu Glu Ile Glu Lys Leu Asn Ala Ala Ser Lys Pro 
305                 310                 315                 320 


Ala Val Gly Asp Tyr Pro Tyr Gly Ala Gly Gly Ile Asn Gln Arg Asn 
                325                 330                 335     


Arg Lys Ile Glu Gly Gly Arg 
            340             


<210>  6
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  6

Met Gln Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Thr Gln 
1               5                   10                  15      


Thr Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Gln Leu Met Asp Asp Tyr Val Ala Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Ala Gly Thr Ser Glu Glu Ile Val Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Arg Pro Glu Ala Ala Arg Gln Val Leu Ile Thr Thr 
65                  70                  75                  80  


Lys Ala Arg Phe Pro Met Gly Ser Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Arg His Leu Asn Gln Ala Leu Asp Ala Ser Leu Gly Arg Leu Gly 
            100                 105                 110         


Val Glu His Ile Asp Leu Tyr Gln Met His Ala Phe Asp Ala Leu Thr 
        115                 120                 125             


Pro Leu Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Ile Arg Asn Gly 
    130                 135                 140                 


Lys Ile Gly Tyr Tyr Gly Phe Ser Asn Phe Ile Gly Trp Gln Leu Thr 
145                 150                 155                 160 


Lys Ala Thr Trp Ile Ala Lys Ala Gly Gly Leu Ala Pro Pro Ile Thr 
                165                 170                 175     


Leu Gln Pro His Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Ala Leu Asp Ala Asp Ile Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Thr Gly Lys Tyr Lys Arg Asp Gln Leu Pro 
    210                 215                 220                 


Thr Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Gln Glu Ser 
225                 230                 235                 240 


Tyr Gly Pro Arg Asn Glu Gln Glu Arg Thr Trp Arg Ile Ile Ala Ala 
                245                 250                 255     


Val Glu Ala Val Ala Lys Ala Leu Gly Val Ser Met Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Leu Ala Asp Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Ala Ala Ala Asp Leu 
    290                 295                 300                 


Arg Leu Asp Ala Glu His Ala Gln Gln Leu Thr Asp Ala Ser Ala Pro 
305                 310                 315                 320 


Glu Val Ala Asp Tyr Pro Tyr Gly Lys Gly Gly Val Asn Gln Arg His 
                325                 330                 335     


Arg Lys Ile Ala Gly Gly Arg 
            340             


<210>  7
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  7

Met Glu Tyr Arg Lys Leu Gly Asn Ser Gly Ala Ile Val Thr Asn Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Lys Glu Ser Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Arg Leu Met Asp Asp Tyr Val Ala Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Asp Gly Leu Ser Glu Gln Ile Ile Gly Gly 
    50                  55                  60                  


Trp Leu Lys Ser Lys Pro Gly Ile Leu Arg Asp Leu Val Ile Thr Thr 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Asp Gly Pro Asn His Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys Asn Leu Ser Glu Ala Leu Asp Ala Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu His Ile Asp Leu Tyr Gln Leu His Ala Phe Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Arg Asn Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp Gln Met Thr 
145                 150                 155                 160 


Lys Ala Val Trp Ile Ala Lys Ala Gly Asn Phe Gln Pro Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Ala Arg Asp Ile Glu His Glu Val 
            180                 185                 190         


Val Pro Ala Ala Leu Asp Ala Gly Ile Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Leu Glu Ala 
225                 230                 235                 240 


Phe Glu Lys Arg Asn Ala Asn Pro Ala Thr Trp Gln Val Ile Gly Ala 
                245                 250                 255     


Leu Glu Asp Ile Ala Lys Ala Arg Gly Ala Ser Met Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Leu Val Lys Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Ala Glu Gln Leu Ala Asp Asn Leu Gly Ala Ala Asp Val 
    290                 295                 300                 


Thr Leu Ser Asp Asp Glu Met Arg Thr Leu Thr Glu Met Ser Ala Pro 
305                 310                 315                 320 


Gln Val Ala Asp Tyr Pro Tyr Gly Glu Gly Gly Asn Arg Gln Arg Asn 
                325                 330                 335     


Arg Arg Met Glu Gly Gly Arg 
            340             


<210>  8
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  8

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


His Leu Leu Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Val Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Lys Pro Glu Ala Ala Ser Asn Leu Val Ile Ala Ser 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Asp Asp Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Val Thr 
145                 150                 155                 160 


Lys Ala Val His Val Ala Lys Ala Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ala Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ser 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Glu Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Glu Ile Ala Lys Asp Arg Gly Ala Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Ser Lys Val 
    290                 295                 300                 


Lys Leu Ser Ala Glu Glu Thr Asp Lys Leu Thr Arg Ile Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Val Ser Gln Arg Phe 
                325                 330                 335     


Arg Lys Met Glu Gly Gly Arg 
            340             


<210>  9
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  9

Met Glu Tyr Arg Lys Leu Gly Asn Ser Gly Thr Ile Val Thr Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Thr Thr Ser 
            20                  25                  30          


His Leu Ile Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Val Ser Glu Glu Ile Val Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Arg Pro Glu Ala Ala Ser Gln Val Val Leu Ala Ser 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Asp Asp Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Leu Thr 
145                 150                 155                 160 


Lys Ala Val His Leu Ala Lys Leu Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ala Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ser 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Asp Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Asp Ile Ala Lys Asp Arg Gly Val Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Ser Lys Leu 
    290                 295                 300                 


Lys Leu Ser Ala Glu Asp Thr Asp Lys Leu Ser Arg Ala Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Ile Ser Gln Arg Phe 
                325                 330                 335     


Arg Lys Met Glu Gly Gly Arg 
            340             


<210>  10
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  10

Met Glu Tyr Arg Lys Leu Gly Asn Ser Gly Thr Ile Val Thr Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Thr Thr Ser 
            20                  25                  30          


His Leu Leu Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Val Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Lys Pro Glu Ala Ala Ser Gln Val Val Ile Ala Ser 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Asp Asp Ser Leu Arg Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Leu Thr 
145                 150                 155                 160 


Lys Ala Val His Leu Ala Lys Leu Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ser Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ser 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Glu Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Glu Ile Ala Lys Asp Arg Gly Ala Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Ser Lys Val 
    290                 295                 300                 


Lys Leu Ser Ala Glu Glu Thr Asp Lys Leu Thr Arg Ile Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Val Ser Gln Arg Phe 
                325                 330                 335     


Arg Lys Met Glu Gly Gly Arg 
            340             


<210>  11
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  11

Met Glu Tyr Arg Lys Leu Gly Asn Ser Gly Thr Ile Val Ser Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


His Leu Ile Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Val Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Arg Pro Glu Ala Ala Ser Asn Val Val Leu Ala Ser 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Glu Asp Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Leu Thr 
145                 150                 155                 160 


Lys Ala Val His Leu Ala Lys Ala Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ala Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ala 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Asp Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Asp Ile Ala Lys Asp Arg Gly Val Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Ser Lys Leu 
    290                 295                 300                 


Lys Leu Ser Ala Glu Asp Thr Asp Lys Leu Ser Arg Ile Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Ile Ser Gln Arg Phe 
                325                 330                 335     


Arg Lys Met Glu Gly Gly Arg 
            340             


<210>  12
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/sequence

<400>  12

Met Glu Tyr Arg Lys Leu Gly Asn Ser Gly Thr Ile Val Thr Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Thr Thr Ser 
            20                  25                  30          


His Leu Ile Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Val Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Lys Pro Glu Ala Ala Ser Asn Leu Val Ile Ala Ser 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Asp Asp Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Leu Thr 
145                 150                 155                 160 


Lys Ala Val His Leu Ala Lys Leu Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ala Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ser 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Asp Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Asp Ile Ala Lys Asp Arg Gly Val Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Ser Lys Val 
    290                 295                 300                 


Lys Leu Ser Ala Glu Glu Thr Asp Lys Leu Thr Arg Ile Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Val Ser Gln Arg Phe 
                325                 330                 335     


Arg Lys Met Glu Gly Gly Arg 
            340             


<210>  13
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  13

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Thr Val Val Thr Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


His Leu Ile Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Val Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Arg Pro Glu Ala Ala Ser Asn Val Val Ile Ala Thr 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Glu Asp Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Ile Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Val Thr 
145                 150                 155                 160 


Lys Ala Val His Leu Ala Lys Ala Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ser Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ala 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Asp Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Glu Ile Ala Lys Asp Arg Gly Val Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Ser Lys Val 
    290                 295                 300                 


Lys Leu Ser Ala Glu Asp Thr Asp Lys Leu Thr Arg Ala Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Val Ser Gln Arg Phe 
                325                 330                 335     


Arg Lys Met Glu Gly Gly Arg 
            340             


<210>  14
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  14

Met Glu Tyr Arg Lys Leu Gly Asn Ser Gly Ala Ile Val Thr Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Thr Thr Ser 
            20                  25                  30          


His Leu Leu Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Val Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Arg Pro Glu Ala Ala Ser Asn Val Val Leu Ala Thr 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Glu Asp Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Val Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Val Thr 
145                 150                 155                 160 


Lys Ala Val His Leu Ala Lys Ala Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ser Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ala 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Asp Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Glu Ile Ala Lys Asp Arg Gly Val Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Ser Lys Val 
    290                 295                 300                 


Lys Leu Ser Ala Glu Asp Thr Asp Lys Leu Thr Arg Ala Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Val Ser Gln Arg Phe 
                325                 330                 335     


Arg Lys Met Glu Gly Gly Arg 
            340             


<210>  15
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  15

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


His Leu Leu Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Val Ser Glu Glu Ile Val Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Arg Pro Glu Ala Ala Ser Gln Val Val Leu Ala Thr 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Ile Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Glu Asp Ser Leu Arg Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Leu Thr 
145                 150                 155                 160 


Lys Ala Val His Leu Ala Lys Leu Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ser Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ser 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Glu Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Glu Ile Ala Lys Asp Arg Gly Ala Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Ser Lys Ser 
    290                 295                 300                 


Lys Leu Ser Ala Glu Asp Thr Asp Lys Leu Thr Arg Ile Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Ile Ser Gln Arg Phe 
                325                 330                 335     


Arg Lys Met Glu Gly Gly Arg 
            340             


<210>  16
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  16

Met Glu Tyr Arg Lys Leu Gly Asn Ser Gly Thr Ile Val Thr Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Thr Thr Ser 
            20                  25                  30          


His Leu Ile Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Val Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Lys Pro Glu Ala Ala Ser Asn Leu Val Ile Ala Ser 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Asp Asp Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Val Thr 
145                 150                 155                 160 


Lys Ala Val His Val Ala Lys Ala Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ala Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ala 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Asp Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Asp Ile Ala Lys Asp Arg Gly Val Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Ser Lys Val 
    290                 295                 300                 


Lys Leu Ser Ala Glu Glu Thr Asp Lys Leu Thr Arg Ile Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Val Ser Gln Arg Phe 
                325                 330                 335     


Arg Lys Met Glu Gly Gly Arg 
            340             


<210>  17
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  17

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Thr Ile Val Thr Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


His Leu Leu Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Val Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Lys Pro Glu Ala Ala Ser Asn Leu Val Ile Ala Ser 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Asp Asp Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Val Thr 
145                 150                 155                 160 


Lys Ala Val His Val Ala Lys Ala Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ser Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ser 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Asp Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Glu Ile Ala Lys Asp Arg Gly Val Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Ser Lys Leu 
    290                 295                 300                 


Lys Leu Ser Ala Glu Glu Thr Asp Lys Leu Thr Arg Ile Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Val Ser Gln Arg Phe 
                325                 330                 335     


Arg Lys Met Glu Gly Gly Arg 
            340             


<210>  18
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  18

Met Glu Tyr Arg Lys Leu Gly Asn Ser Gly Thr Ile Val Thr Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Ala Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


His Leu Leu Leu Asp Asp Tyr Val Glu Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Leu Gly Leu Ser Glu Gln Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Lys Pro Glu Ala Ala Ser Gln Val Val Ile Ala Ser 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Lys His Leu Asn Arg Ala Leu Asp Asp Ser Leu Lys Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Gly Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Leu Thr 
145                 150                 155                 160 


Lys Ala Val His Val Ala Lys Ala Asn His Trp Ser Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Ala Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Leu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ala Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Thr Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ala 
225                 230                 235                 240 


Phe Gly Pro Arg Asn Ala Gln Glu Arg Thr Trp Gln Ile Ile Asp Ala 
                245                 250                 255     


Val Ala Glu Ile Ala Lys Asp Arg Gly Ala Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Glu Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ser Val Lys Val 
    290                 295                 300                 


Lys Leu Ser Ala Glu Glu Thr Asp Lys Leu Thr Arg Ile Ser Met Pro 
305                 310                 315                 320 


Gln Met Ser Asp Tyr Pro Tyr Gly Glu Arg Gly Val Ser Gln Arg Phe 
                325                 330                 335     


Arg Arg Met Glu Gly Gly Arg 
            340             


<210>  19
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  19

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Asn Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Asp Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Leu Leu Met Asp Gln Tyr Val Glu Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Thr Gly Val Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Lys Arg Leu Arg Asn Leu Val Ile Ala Ser Lys Gly 
65                  70                  75                  80  


Arg Phe Pro Met Gly Asn Gly Pro Asn His Leu Gly Leu Ser Arg Lys 
                85                  90                  95      


His Leu Gly Glu Ala Leu Asp Ala Ser Leu Gln Arg Leu Gly Val Glu 
            100                 105                 110         


Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro Leu 
        115                 120                 125             


Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Arg Ser Gly Lys Ile 
    130                 135                 140                 


Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp His Leu Thr Lys Ala 
145                 150                 155                 160 


Val Trp Met Ala Lys Leu Asn Gly Tyr Ala Ala Pro Val Thr Leu Gln 
                165                 170                 175     


Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Val Val Pro 
            180                 185                 190         


Ala Cys Glu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro Glu Gly 
    210                 215                 220                 


Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala Tyr Glu 
225                 230                 235                 240 


Gly Arg Asn Ala Gln Asp Arg Thr Trp Ser Ile Ile Gly Ala Val Glu 
                245                 250                 255     


Asp Ile Ala Lys Ala Gln Asp Val Thr Met Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Thr Ala Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly Ala Arg 
        275                 280                 285             


Thr Ala Glu Gln Leu Lys Asp Asn Leu Gly Ala Ala Asp Leu Val Leu 
    290                 295                 300                 


Ser Glu Ala Asp Met Glu Arg Leu Asn Ala Val Ser Ala Pro Gln Met 
305                 310                 315                 320 


Ala Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Gly Gln Arg Asn Arg Lys 
                325                 330                 335     


Ile Glu Gly Gly Arg 
            340     


<210>  20
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  20

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Asn Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Asp Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Val Leu Met Asp Gln Tyr Val Glu Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Ala Gly Leu Ser Glu Glu Ile Val Gly Arg 
    50                  55                  60                  


Trp Leu Lys Gly Lys Lys Leu Arg Asp Leu Val Ile Ala Thr Lys Gly 
65                  70                  75                  80  


Arg Phe Pro Met Gly Asn Gly Pro Asn His Leu Gly Leu Ser Arg Lys 
                85                  90                  95      


His Leu Gly Glu Ala Leu Asp Ala Ser Leu Gln Arg Leu Gly Val Glu 
            100                 105                 110         


Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro Leu 
        115                 120                 125             


Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Arg Ser Gly Lys Ile 
    130                 135                 140                 


Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp His Leu Thr Lys Ala 
145                 150                 155                 160 


Val Trp Met Ala Lys Leu Asn Gly Tyr Ala Ala Pro Val Thr Leu Gln 
                165                 170                 175     


Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Val Val Pro 
            180                 185                 190         


Ala Cys Glu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro Glu Gly 
    210                 215                 220                 


Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala Tyr Glu 
225                 230                 235                 240 


Gly Arg Asn Ala Gln Asp Arg Thr Trp Ser Ile Ile Gly Ala Val Glu 
                245                 250                 255     


Asp Ile Ala Lys Ala Gln Asn Val Ser Met Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Thr Val Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly Ala Arg 
        275                 280                 285             


Thr Ala Glu Gln Leu Lys Asp Asn Leu Gly Ser Val Asp Leu Val Leu 
    290                 295                 300                 


Ser Glu Ala Asp Met Glu Arg Leu Asn Ala Ala Ser Ala Pro Gln Met 
305                 310                 315                 320 


Ser Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Gly Gln Arg Asn Arg Lys 
                325                 330                 335     


Leu Glu Gly Gly Arg 
            340     


<210>  21
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  21

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Asn Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Asp Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Leu Leu Met Asp Gln Tyr Val Glu Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Thr Gly Val Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Gly Lys Lys Leu Arg Asp Leu Val Ile Ala Thr Lys Gly 
65                  70                  75                  80  


Arg Phe Pro Met Gly Gln Gly Pro Asn His Leu Gly Leu Ser Arg Lys 
                85                  90                  95      


His Leu Gly Glu Ala Leu Asp Ala Ser Leu Gln Arg Leu Gly Val Glu 
            100                 105                 110         


Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro Leu 
        115                 120                 125             


Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Arg Ser Gly Lys Ile 
    130                 135                 140                 


Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp His Leu Thr Lys Ala 
145                 150                 155                 160 


Val Trp Met Ala Lys Leu Asn Gly Tyr Ala Ala Pro Val Thr Leu Gln 
                165                 170                 175     


Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Val Val Pro 
            180                 185                 190         


Ala Cys Glu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro Glu Gly 
    210                 215                 220                 


Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala Tyr Glu 
225                 230                 235                 240 


Gly Arg Asn Ala Gln Asp Arg Thr Trp Ser Ile Ile Gly Ala Val Glu 
                245                 250                 255     


Asp Ile Ala Lys Ala Gln Asp Val Thr Met Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Thr Ala Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly Ala Arg 
        275                 280                 285             


Thr Ala Glu Gln Leu Lys Asp Asn Leu Gly Ser Val Asp Leu Val Leu 
    290                 295                 300                 


Ser Glu Ala Asp Met Glu Arg Leu Asn Ala Ala Ser Ala Pro Gln Met 
305                 310                 315                 320 


Ser Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Gly Gln Arg Asn Arg Lys 
                325                 330                 335     


Leu Glu Gly Gly Arg 
            340     


<210>  22
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  22

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Asn Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Asp Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Val Leu Met Asp Gln Tyr Val Glu Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Ala Gly Leu Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Lys Arg Leu Arg Asn Leu Val Ile Ala Ser Lys Gly 
65                  70                  75                  80  


Arg Phe Pro Met Gly Asn Gly Pro Asn His Leu Gly Leu Ser Arg Lys 
                85                  90                  95      


His Leu Gly Glu Ala Leu Asp Ala Ser Leu Gln Arg Leu Gly Val Glu 
            100                 105                 110         


Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro Leu 
        115                 120                 125             


Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Ile Arg Ser Gly Lys Ile 
    130                 135                 140                 


Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp His Ile Thr Lys Ala 
145                 150                 155                 160 


Val Trp Met Ala Arg Ala Gln Gly Tyr Ala Ala Pro Val Thr Leu Gln 
                165                 170                 175     


Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Val Val Pro 
            180                 185                 190         


Ala Cys Glu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro Glu Gly 
    210                 215                 220                 


Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala Tyr Glu 
225                 230                 235                 240 


Gly Arg Asn Ala Gln Asp Arg Thr Trp Ser Ile Ile Gly Ala Val Glu 
                245                 250                 255     


Asp Ile Ala Lys Ala Gln Asn Val Ser Met Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Thr Ala Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly Ala Arg 
        275                 280                 285             


Thr Ala Glu Gln Leu Lys Asp Asn Leu Gly Ser Val Asp Leu Val Leu 
    290                 295                 300                 


Ser Glu Ala Asp Met Glu Arg Leu Asn Ala Ala Ser Ala Pro Gln Met 
305                 310                 315                 320 


Ser Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Gly Gln Arg Asn Arg Lys 
                325                 330                 335     


Leu Glu Gly Gly Arg 
            340     


<210>  23
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  23

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Asn Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Asp Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Leu Leu Met Asp Gln Tyr Val Glu Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Ala Gly Val Ser Glu Glu Ile Val Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Lys Lys Leu Arg Asn Leu Val Ile Ala Thr Lys Gly 
65                  70                  75                  80  


Arg Phe Pro Met Gly Asn Gly Pro Asn His Leu Gly Leu Ser Arg Lys 
                85                  90                  95      


His Leu Gly Glu Ala Leu Asp Ala Ser Leu Gln Arg Leu Gly Val Glu 
            100                 105                 110         


Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro Leu 
        115                 120                 125             


Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Ile Arg Ser Gly Lys Ile 
    130                 135                 140                 


Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp His Ile Thr Lys Ala 
145                 150                 155                 160 


Val Trp Met Ala Lys Ala Asn Gly Tyr Ala Ala Pro Val Thr Leu Gln 
                165                 170                 175     


Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Val Val Pro 
            180                 185                 190         


Ala Cys Glu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro Glu Gly 
    210                 215                 220                 


Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala Tyr Glu 
225                 230                 235                 240 


Gly Arg Asn Ala Gln Glu Arg Thr Trp Ser Ile Ile Gly Ala Val Glu 
                245                 250                 255     


Asp Ile Ala Lys Ala Gln Asp Val Ser Met Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Thr Ala Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly Ala Arg 
        275                 280                 285             


Thr Ala Glu Gln Leu Lys Asp Asn Leu Gly Ser Ala Asp Leu Val Leu 
    290                 295                 300                 


Ser Glu Ala Asp Met Glu Arg Leu Asn Ala Ala Ser Ala Pro Gln Met 
305                 310                 315                 320 


Ala Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Gly Gln Arg Asn Arg Lys 
                325                 330                 335     


Leu Glu Gly Gly Arg 
            340     


<210>  24
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  24

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Asn Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Asp Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Val Leu Met Asp Gln Tyr Val Glu Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Thr Gly Leu Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Gly Lys Arg Leu Arg Asp Leu Val Ile Ala Ser Lys Gly 
65                  70                  75                  80  


Arg Phe Pro Met Gly Gln Gly Pro Asn His Leu Gly Leu Ser Arg Lys 
                85                  90                  95      


His Leu Gly Glu Ala Leu Asp Ala Ser Leu Gln Arg Leu Gly Val Glu 
            100                 105                 110         


Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro Leu 
        115                 120                 125             


Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Val Arg Ser Gly Lys Ile 
    130                 135                 140                 


Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp His Leu Thr Lys Ala 
145                 150                 155                 160 


Val Trp Met Ala Arg Leu Gln Gly Tyr Ala Ala Pro Val Thr Leu Gln 
                165                 170                 175     


Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Val Val Pro 
            180                 185                 190         


Ala Cys Glu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro Glu Gly 
    210                 215                 220                 


Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala Tyr Glu 
225                 230                 235                 240 


Gly Arg Asn Ala Gln Asp Arg Thr Trp Ala Ile Ile Gly Ala Val Glu 
                245                 250                 255     


Asp Ile Ala Lys Ala Gln Asn Val Thr Met Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Thr Val Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly Ala Arg 
        275                 280                 285             


Thr Ala Glu Gln Leu Lys Asp Asn Leu Gly Ala Val Asp Leu Val Leu 
    290                 295                 300                 


Ser Glu Ala Asp Met Glu Arg Leu Asn Ala Val Ser Ala Pro Gln Met 
305                 310                 315                 320 


Ser Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Gly Gln Arg Asn Arg Lys 
                325                 330                 335     


Ile Glu Gly Gly Arg 
            340     


<210>  25
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  25

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Asn Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Asp Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Leu Leu Met Asp Gln Tyr Val Glu Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Ala Gly Leu Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Lys Arg Leu Arg Asp Leu Val Ile Ala Thr Lys Gly 
65                  70                  75                  80  


Arg Phe Pro Met Gly Asn Gly Pro Asn His Leu Gly Leu Ser Arg Lys 
                85                  90                  95      


His Leu Gly Glu Ala Leu Asp Ala Ser Leu Gln Arg Leu Gly Val Glu 
            100                 105                 110         


Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro Leu 
        115                 120                 125             


Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Arg Ser Gly Lys Ile 
    130                 135                 140                 


Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp His Leu Thr Lys Ala 
145                 150                 155                 160 


Val Trp Met Ala Lys Ala Gln Gly Tyr Ala Ala Pro Val Thr Leu Gln 
                165                 170                 175     


Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Val Val Pro 
            180                 185                 190         


Ala Cys Glu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro Glu Gly 
    210                 215                 220                 


Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala Tyr Glu 
225                 230                 235                 240 


Gly Arg Asn Ala Gln Asp Arg Thr Trp Ala Ile Ile Gly Ala Val Glu 
                245                 250                 255     


Asp Ile Ala Lys Ala Gln Asp Val Ser Met Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Thr Val Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly Ala Arg 
        275                 280                 285             


Thr Ala Glu Gln Leu Lys Asp Asn Leu Gly Ser Ala Asp Leu Val Leu 
    290                 295                 300                 


Ser Glu Ala Asp Met Glu Arg Leu Asn Ala Val Ser Ala Pro Gln Met 
305                 310                 315                 320 


Ser Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Gly Gln Arg Asn Arg Lys 
                325                 330                 335     


Leu Glu Gly Gly Arg 
            340     


<210>  26
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  26

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Asn Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Asp Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Leu Leu Met Asp Gln Tyr Val Glu Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Thr Gly Val Ser Glu Glu Ile Val Gly Arg 
    50                  55                  60                  


Trp Leu Lys Gly Lys Lys Leu Arg Asp Leu Val Ile Ala Thr Lys Gly 
65                  70                  75                  80  


Arg Phe Pro Met Gly Gln Gly Pro Asn His Leu Gly Leu Ser Arg Lys 
                85                  90                  95      


His Leu Gly Glu Ala Leu Asp Ala Ser Leu Gln Arg Leu Gly Val Glu 
            100                 105                 110         


Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro Leu 
        115                 120                 125             


Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Arg Ser Gly Lys Ile 
    130                 135                 140                 


Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp His Leu Thr Lys Ala 
145                 150                 155                 160 


Val Trp Met Ala Lys Leu Asn Gly Tyr Ala Ala Pro Val Thr Leu Gln 
                165                 170                 175     


Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Val Val Pro 
            180                 185                 190         


Ala Cys Glu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro Glu Gly 
    210                 215                 220                 


Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala Tyr Glu 
225                 230                 235                 240 


Gly Arg Asn Ala Gln Glu Arg Thr Trp Ala Ile Ile Gly Ala Val Glu 
                245                 250                 255     


Asp Ile Ala Lys Ala Gln Asp Val Thr Met Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Thr Val Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly Ala Arg 
        275                 280                 285             


Thr Ala Glu Gln Leu Lys Asp Asn Leu Gly Ser Val Asp Leu Val Leu 
    290                 295                 300                 


Ser Glu Ala Asp Met Glu Arg Leu Asn Ala Ala Ser Ala Pro Gln Met 
305                 310                 315                 320 


Ala Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Gly Gln Arg Asn Arg Lys 
                325                 330                 335     


Ile Glu Gly Gly Arg 
            340     


<210>  27
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  27

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Asn Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Asp Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Leu Leu Met Asp Gln Tyr Val Glu Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Thr Gly Leu Ser Glu Glu Ile Ile Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Lys Lys Leu Arg Asp Leu Val Ile Ala Ser Lys Gly 
65                  70                  75                  80  


Arg Phe Pro Met Gly Asn Gly Pro Asn His Leu Gly Leu Ser Arg Lys 
                85                  90                  95      


His Leu Gly Glu Ala Leu Asp Ala Ser Leu Gln Arg Leu Gly Val Glu 
            100                 105                 110         


Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro Leu 
        115                 120                 125             


Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Arg Ser Gly Lys Ile 
    130                 135                 140                 


Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp His Leu Thr Lys Ala 
145                 150                 155                 160 


Val Trp Met Ala Arg Ala Asn Gly Tyr Ala Ala Pro Val Thr Leu Gln 
                165                 170                 175     


Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Val Val Pro 
            180                 185                 190         


Ala Cys Glu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro Glu Gly 
    210                 215                 220                 


Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala Tyr Glu 
225                 230                 235                 240 


Gly Arg Asn Ala Gln Asp Arg Thr Trp Ser Ile Ile Gly Ala Val Glu 
                245                 250                 255     


Asp Ile Ala Lys Ala Gln Asp Val Thr Met Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Thr Val Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly Ala Arg 
        275                 280                 285             


Thr Ala Glu Gln Leu Lys Asp Asn Leu Gly Ala Ala Asp Leu Val Leu 
    290                 295                 300                 


Ser Glu Ala Asp Met Glu Arg Leu Asn Ala Val Ser Ala Pro Gln Met 
305                 310                 315                 320 


Ala Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Gly Gln Arg Asn Arg Lys 
                325                 330                 335     


Ile Glu Gly Gly Arg 
            340     


<210>  28
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  28

Met Asp Tyr Arg Lys Leu Gly Asn Ser Gly Ala Val Val Ser Asn Leu 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Asp Glu Ala Asp Glu Ala Thr Ser 
            20                  25                  30          


Phe Val Leu Met Asp Gln Tyr Val Glu Ala Gly Gly Asn Phe Leu Asp 
        35                  40                  45              


Thr Ala Asp Val Tyr Ser Thr Gly Val Ser Glu Glu Ile Asn Gly Arg 
    50                  55                  60                  


Trp Leu Lys Gly Lys Lys Leu Arg Asp Leu Val Ile Ala Thr Lys Gly 
65                  70                  75                  80  


Arg Phe Pro Met Gly Asn Gly Pro Asn His Leu Gly Leu Ser Arg Lys 
                85                  90                  95      


His Leu Gly Glu Ala Leu Asp Ala Ser Leu Gln Arg Leu Gly Val Glu 
            100                 105                 110         


Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro Leu 
        115                 120                 125             


Glu Glu Thr Leu Arg Phe Leu Asp Asp Ser Ile Arg Ser Gly Lys Ile 
    130                 135                 140                 


Ala Tyr Tyr Gly Phe Ser Asn Phe Leu Gly Trp His Leu Thr Lys Ala 
145                 150                 155                 160 


Val Trp Met Ala Lys Leu Asn Gly Tyr Ala Ala Pro Val Thr Leu Gln 
                165                 170                 175     


Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Val Val Pro 
            180                 185                 190         


Ala Cys Glu Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu Gly 
        195                 200                 205             


Gly Gly Trp Leu Ser Gly Lys Tyr Lys Arg Asp Gln Met Pro Glu Gly 
    210                 215                 220                 


Ala Thr Arg Leu Gly Glu Asn Pro Lys Arg Gly Met Glu Ala Tyr Glu 
225                 230                 235                 240 


Gly Arg Asn Ala Gln Glu Arg Thr Trp Ala Ile Ile Gly Ala Val Glu 
                245                 250                 255     


Asp Ile Ala Lys Ala Gln Asp Val Thr Met Ala Gln Val Ala Leu Ala 
            260                 265                 270         


Trp Thr Ala Ala Arg Pro Ala Val Thr Ser Val Ile Leu Gly Ala Arg 
        275                 280                 285             


Thr Ala Glu Gln Leu Lys Asp Asn Leu Gly Ala Val Asp Leu Val Leu 
    290                 295                 300                 


Ser Glu Ala Asp Met Glu Arg Leu Asn Ala Ala Ser Ala Pro Gln Met 
305                 310                 315                 320 


Ser Asp Tyr Pro Tyr Gly Thr Gly Gly Ile Gly Gln Arg Asn Arg Lys 
                325                 330                 335     


Ile Glu Gly Gly Arg 
            340     


<210>  29
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  29

Met Glu Tyr Arg Lys Leu Gly Asn Ser Gly Thr Val Val Thr Ser Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Phe Gly Gln Glu Thr Asp Glu Ala Thr Ser 
            20                  25                  30          


His Leu Ile Met Asp Asp Tyr Ile Lys Ala Gly Gly Asn Phe Ile Asp 
        35                  40                  45              


Thr Ala Asn Val Tyr Ser Ala Gly Val Ser Glu Glu Ile Val Gly Arg 
    50                  55                  60                  


Trp Leu Lys Ala Arg Pro Ser Glu Ala Arg Gln Val Val Val Ala Thr 
65                  70                  75                  80  


Lys Gly Arg Phe Pro Met Gly Ala Gly Pro Asn Asp Leu Gly Leu Ser 
                85                  90                  95      


Arg Thr Asn Leu Asn Arg Ala Leu Asn Asp Ser Leu Arg Arg Leu Gly 
            100                 105                 110         


Val Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Val Thr 
        115                 120                 125             


Pro Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Ser Ala Gly 
    130                 135                 140                 


Lys Ile Ala Tyr Tyr Gly Phe Ser Asn Tyr Leu Gly Trp Gln Val Thr 
145                 150                 155                 160 


Lys Ala Val His Val Ala Arg Ala Asn His Trp Thr Ala Pro Val Thr 
                165                 170                 175     


Leu Gln Pro Gln Tyr Asn Leu Leu Val Arg Asp Ile Glu His Glu Ile 
            180                 185                 190         


Val Pro Ala Cys Gln Asp Ala Ala Met Gly Leu Leu Pro Trp Ser Pro 
        195                 200                 205             


Leu Gly Gly Gly Trp Leu Ala Gly Lys Tyr Gln Arg Asp Val Met Pro 
    210                 215                 220                 


Ser Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Met Glu Ser 
225                 230                 235                 240 


Tyr Gly Pro Arg Asn Ala Gln Glu Arg Thr Trp Gln Ile Ile Asp Met 
                245                 250                 255     


Val Ala Glu Ile Ala Lys Glu Arg Gly Val Ser Ala Ala Gln Val Ala 
            260                 265                 270         


Leu Ala Trp Val Val Ala Arg Pro Ala Val Thr Ala Val Ile Leu Gly 
        275                 280                 285             


Ala Arg Thr Arg Glu Gln Leu Ala Asp Asn Leu Gly Ala Val Ala Val 
    290                 295                 300                 


Thr Leu Ser Thr Glu Glu Met Glu Arg Leu Asn Arg Val Ser Ala Pro 
305                 310                 315                 320 


Ala Met Ala Asp Tyr Pro Tyr Gly Glu Arg Gly Val Ser Gln Arg His 
                325                 330                 335     


Arg Lys Met Asp Gly Gly Arg 
            340             


<210>  30
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  30

Met Asp Tyr Arg Lys Leu Gly Pro Ser Gly Thr Val Val Thr Ala Tyr 
1               5                   10                  15      


Cys Leu Gly Thr Met Thr Gly Ala Glu Ala Asp Glu Ala Ala Ser His 
            20                  25                  30          


Lys Leu Leu Asp Asp Tyr Phe Ala Trp Gly Gly Asn Phe Ile Asp Thr 
        35                  40                  45              


Ala Asp Val Tyr Ser Ala Gly Lys Ser Glu Glu Ile Ile Gly Arg Trp 
    50                  55                  60                  


Leu Lys Ala Arg Pro Thr Glu Ala Arg Gln Ala Ile Val Ala Thr Lys 
65                  70                  75                  80  


Gly Arg Phe Pro Met Gly Asn Gly Pro Asn Asp Ile Gly Leu Ser Arg 
                85                  90                  95      


Arg His Leu Ser Gln Ala Leu Asp Asp Ser Leu Arg Arg Leu Gly Leu 
            100                 105                 110         


Glu Gln Ile Asp Leu Tyr Gln Met His Ala Trp Asp Ala Leu Thr Pro 
        115                 120                 125             


Ile Glu Glu Thr Leu Arg Phe Leu Asp Asp Ala Val Ser Ser Gly Lys 
    130                 135                 140                 


Ile Gly Tyr Tyr Gly Phe Ser Asn Tyr Val Gly Trp His Ile Ala Lys 
145                 150                 155                 160 


Ala Ser Glu Ile Ala Lys Ala Arg Gly Tyr Thr Arg Pro Val Thr Leu 
                165                 170                 175     


Gln Pro Gln Tyr Asn Leu Leu Met Arg Asp Ile Glu Leu Glu Ile Val 
            180                 185                 190         


Ala Ala Cys Gln Asp Ala Gly Met Gly Leu Leu Pro Trp Ser Pro Leu 
        195                 200                 205             


Gly Gly Gly Trp Leu Thr Gly Lys Tyr Lys Arg Asp Glu Met Pro Thr 
    210                 215                 220                 


Gly Ala Thr Arg Leu Gly Glu Asn Pro Asn Arg Gly Gly Glu Ser Tyr 
225                 230                 235                 240 


Ala Pro Arg Asn Ala Gln Glu Arg Thr Trp Ala Ile Ile Gly Thr Val 
                245                 250                 255     


Glu Glu Ile Ala Lys Ala Arg Gly Val Ser Met Ala Gln Val Ala Leu 
            260                 265                 270         


Ala Trp Thr Ala Ala Arg Pro Ala Ile Thr Ser Val Ile Leu Gly Ala 
        275                 280                 285             


Arg Thr Pro Glu Gln Leu Ala Asp Asn Leu Gly Ala Met Lys Val Glu 
    290                 295                 300                 


Leu Ser Gly Glu Glu Met Ala Arg Leu Asn Glu Val Ser Ala Pro Gln 
305                 310                 315                 320 


Pro Leu Asp Tyr Pro Tyr Gly Lys Gly Gly Ile Asn Gln Arg His Arg 
                325                 330                 335     


Lys Ile Glu Gly Gly Arg 
            340         


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  31

Tyr Arg Lys Leu Gly Asn Ser Gly 
1               5               


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  32

Leu Gly Thr Met Thr Phe Gly 
1               5           


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is I or L

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is N or D

<400>  33

Ala Gly Gly Asn Phe Xaa Asp Thr Ala Xaa Val Tyr Ser 
1               5                   10              


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  34

Glu Thr Leu Arg Phe Leu Asp Asp 
1               5               


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is A or G

<400>  35

Gly Lys Ile Xaa Tyr Tyr Gly Phe Ser Asn 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is I or V

<400>  36

Arg Asp Ile Glu His Glu Xaa Val Pro Ala 
1               5                   10  


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  37

Gly Leu Leu Pro Trp Ser Pro Leu Gly Gly Gly Trp Leu 
1               5                   10              


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  38

Gly Ala Thr Arg Leu Gly Glu Asn Pro 
1               5                   


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif

<400>  39

Ala Gln Val Ala Leu Ala Trp 
1               5           


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  motif


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is T or A

<400>  40

Pro Ala Val Xaa Ser Val Ile Leu Gly Ala Arg Thr 
1               5                   10          


<210>  41
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  41

Met Arg Phe Glu Tyr Leu Arg Gln Asn Val Val Gly Leu Ala Leu Ser 
1               5                   10                  15      


Thr Ala Leu Ile Ala Ser Leu Ser Gly Pro Ala Phe Ala Gln His Asp 
            20                  25                  30          


Ala Asn Ala Ala Ala Glu Pro Ser Lys Ala Gly Gln Ser Ala Ile Glu 
        35                  40                  45              


Asn Phe Gln Pro Val Thr Ala Asp Asp Leu Ala Gly Lys Asn Pro Ala 
    50                  55                  60                  


Asn Trp Pro Ile Leu Arg Gly Asn Tyr Gln Gly Trp Gly Tyr Ser Pro 
65                  70                  75                  80  


Leu Asp Gln Ile Asn Lys Asp Asn Val Gly Asp Leu Gln Leu Val Trp 
                85                  90                  95      


Ser Arg Thr Met Glu Pro Gly Ser Asn Glu Gly Ala Ala Ile Ala Tyr 
            100                 105                 110         


Asn Gly Val Ile Phe Leu Gly Asn Thr Asn Asp Val Ile Gln Ala Ile 
        115                 120                 125             


Asp Gly Lys Thr Gly Ser Leu Ile Trp Glu Tyr Arg Arg Lys Leu Pro 
    130                 135                 140                 


Ser Ala Ser Lys Phe Ile Asn Ser Leu Gly Ala Ala Lys Arg Ser Ile 
145                 150                 155                 160 


Ala Leu Phe Gly Asp Lys Val Tyr Phe Val Ser Trp Asp Asn Phe Val 
                165                 170                 175     


Val Ala Leu Asp Ala Lys Thr Gly Lys Leu Ala Trp Glu Thr Asn Arg 
            180                 185                 190         


Gly Gln Gly Val Glu Glu Gly Val Ala Asn Ser Ser Gly Pro Ile Val 
        195                 200                 205             


Val Asp Gly Val Val Ile Ala Gly Ser Thr Cys Gln Phe Ser Gly Phe 
    210                 215                 220                 


Gly Cys Tyr Val Thr Gly Thr Asp Ala Glu Ser Gly Glu Glu Leu Trp 
225                 230                 235                 240 


Arg Asn Thr Phe Ile Pro Arg Pro Gly Glu Glu Gly Asp Asp Thr Trp 
                245                 250                 255     


Gly Gly Ala Pro Tyr Glu Asn Arg Trp Met Thr Gly Ala Trp Gly Gln 
            260                 265                 270         


Ile Thr Tyr Asp Pro Glu Leu Asp Leu Val Tyr Tyr Gly Ser Thr Gly 
        275                 280                 285             


Ala Gly Pro Ala Ser Glu Val Gln Arg Gly Thr Glu Gly Gly Thr Leu 
    290                 295                 300                 


Ala Gly Thr Asn Thr Arg Phe Ala Val Lys Pro Lys Thr Gly Glu Val 
305                 310                 315                 320 


Val Trp Lys His Gln Thr Leu Pro Arg Asp Asn Trp Asp Ser Glu Cys 
                325                 330                 335     


Thr Phe Glu Met Met Val Val Ser Thr Ser Val Asn Pro Asp Ala Lys 
            340                 345                 350         


Ala Asp Gly Met Met Ser Val Gly Ala Asn Val Pro Arg Gly Glu Thr 
        355                 360                 365             


Arg Lys Val Leu Thr Gly Val Pro Cys Lys Thr Gly Val Ala Trp Gln 
    370                 375                 380                 


Phe Asp Ala Lys Thr Gly Asp Tyr Phe Trp Ser Lys Ala Thr Val Glu 
385                 390                 395                 400 


Gln Asn Ser Ile Ala Ser Ile Asp Asp Thr Gly Leu Val Thr Val Asn 
                405                 410                 415     


Glu Asp Met Ile Leu Lys Glu Pro Gly Lys Thr Tyr Asn Tyr Cys Pro 
            420                 425                 430         


Thr Phe Leu Gly Gly Arg Asp Trp Pro Ser Ala Gly Tyr Leu Pro Lys 
        435                 440                 445             


Ser Asn Leu Tyr Val Ile Pro Leu Ser Asn Ala Cys Tyr Asp Val Met 
    450                 455                 460                 


Ala Arg Thr Thr Glu Ala Thr Pro Ala Asp Val Tyr Asn Thr Asp Ala 
465                 470                 475                 480 


Thr Leu Val Leu Ala Pro Gly Lys Thr Asn Met Gly Arg Val Asp Ala 
                485                 490                 495     


Ile Asp Leu Ala Thr Gly Glu Thr Lys Trp Ser Tyr Glu Thr Arg Ala 
            500                 505                 510         


Ala Leu Tyr Asp Pro Val Leu Thr Thr Gly Gly Asp Leu Val Phe Val 
        515                 520                 525             


Gly Gly Ile Asp Arg Asp Phe Arg Ala Leu Asp Ala Glu Ser Gly Lys 
    530                 535                 540                 


Glu Val Trp Ser Thr Arg Leu Pro Gly Ala Val Ser Gly Tyr Thr Thr 
545                 550                 555                 560 


Ser Tyr Ser Ile Asp Gly Arg Gln Tyr Val Ala Val Val Ser Gly Gly 
                565                 570                 575     


Ser Leu Gly Gly Pro Thr Phe Gly Pro Thr Thr Pro Asp Val Asp Ser 
            580                 585                 590         


Ala Ser Gly Ala Asn Gly Ile Tyr Val Phe Ala Leu Pro Glu Lys Lys 
        595                 600                 605             


<210>  42
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide/enzyme

<400>  42

Met Lys Lys Arg Thr Ser Ile Leu Leu Ala Ser Val Ala Met Leu Gly 
1               5                   10                  15      


Met Gly Ser Thr Ala Phe Ala Gln Val Asp Ile Asn Ala Leu Pro Ala 
            20                  25                  30          


Val Thr Asp Ala Ile Leu Ala Asn Pro Asp Ala Gly Asp Trp Pro Ser 
        35                  40                  45              


Tyr Gly Arg Asp Ile Thr Asn Tyr Arg Phe Ser Pro Leu Asp Gln Val 
    50                  55                  60                  


Asn Lys Asp Asn Val Gly Gln Leu Thr Leu Ala Trp Ala Arg Ala Leu 
65                  70                  75                  80  


Glu Pro Gly Asn Leu Gln Ser Ala Pro Leu Glu Phe Gly Gly Val Leu 
                85                  90                  95      


Phe Thr Ala Ala Pro Gly Asp Val Val Gln Ala Met Asp Ala Ala Thr 
            100                 105                 110         


Gly Gln Leu Ile Trp Glu Tyr Arg Arg Gln Leu Pro Asp Arg Ala Thr 
        115                 120                 125             


Leu Asn Ser Leu Gly Glu Asn Lys Arg Gly Ile Ala Leu Tyr Glu Asp 
    130                 135                 140                 


Lys Ile Tyr Val Ala Thr Trp Asp Asn Phe Ile Val Ala Leu Asp Ala 
145                 150                 155                 160 


Lys Thr Gly Gln Val Ala Trp Glu Ser Asp Arg Gly Gly Gly Ala Asp 
                165                 170                 175     


Leu Ile Ser Asn Thr Thr Gly Pro Ile Val Ala Asn Gly Val Val Val 
            180                 185                 190         


Ala Gly Ser Thr Cys Gln Phe Ser Glu Phe Gly Cys Tyr Val Thr Gly 
        195                 200                 205             


His Asp Ala Ala Thr Gly Glu Glu Leu Trp Arg Asn Asn Phe Ile Pro 
    210                 215                 220                 


Lys Lys Gly Glu Glu Gly Asp Asp Thr Trp Gly Asp Ser Thr Glu Asp 
225                 230                 235                 240 


Gln Arg Trp Met Thr Gly Ala Trp Gly Gln Met Thr Tyr Asp Pro Glu 
                245                 250                 255     


Leu Asp Leu Val Tyr Tyr Gly Ser Thr Gly Ala Gly Pro Ala Ala Glu 
            260                 265                 270         


Phe Gln Arg Asn Thr Val Gly Gly Thr Leu Phe Gly Ser Asn Thr Arg 
        275                 280                 285             


Phe Ala Val Lys Pro Lys Thr Gly Glu Ile Val Trp Arg His Gln Val 
    290                 295                 300                 


Leu Pro Arg Asp Asn Trp Asp Gln Glu Cys Thr Tyr Glu Met Val Pro 
305                 310                 315                 320 


Val Asp Ile Asp Ser Ala Pro Ala Ala Asp Met Glu Gly Leu Leu Ala 
                325                 330                 335     


Leu Gly Thr Ala Ala Pro Gly Lys Lys Arg Val Leu Thr Gly Val Pro 
            340                 345                 350         


Cys Lys Thr Gly Val Met Trp Gln Phe Asp Ala Gln Thr Gly Glu Phe 
        355                 360                 365             


Ile Tyr Ala Arg Asp Thr Val Gln Gln Thr Leu Ile Glu Ser Val Asp 
    370                 375                 380                 


Asn Thr Gly Leu Val Thr Val Asn Glu Ala Ala Ile Pro Thr Glu Val 
385                 390                 395                 400 


Asp Val Ala Thr Pro Met Cys Pro Thr Tyr Leu Gly Gly Arg Asp Trp 
                405                 410                 415     


Ser Pro Thr Ala Phe Asn Pro Thr Ser Lys Val Met Phe Val Pro Leu 
            420                 425                 430         


Thr Asn Met Cys Ala Asp Val Thr Val Leu Asp Gln Glu Pro Thr Gly 
        435                 440                 445             


Leu Asp Val Tyr Asn Thr Glu Leu Thr Tyr Lys Met Pro Glu Gly Val 
    450                 455                 460                 


Thr Asp Ala Gly Arg Ile Asp Ala Ile Asn Val Glu Thr Gly Lys Thr 
465                 470                 475                 480 


Leu Trp Ser Trp Thr Gln Gln Thr Pro Gln Tyr Ala Ser Ile Thr Ala 
                485                 490                 495     


Thr Ala Gly Gly Leu Ile Phe Thr Gly Gly Ala Asp Arg Arg Phe Lys 
            500                 505                 510         


Ala Ile Asp Gln Glu Thr Gly Glu Leu Val Trp Ser Val Thr Leu Gly 
        515                 520                 525             


Ser Arg Ala Thr Gly His Pro Ile Ser Tyr Glu Val Asp Gly Arg Gln 
    530                 535                 540                 


Tyr Ile Ala Ile Pro Ala Gly Gly Pro Gly Tyr Ala Thr Asp Leu Ile 
545                 550                 555                 560 


Thr Ala Ser Gly Ser Thr Val Asp Val Val Ser Gly Ser Asn Met Leu 
                565                 570                 575     


Tyr Val Phe Ala Leu Pro Glu Gln Lys Lys 
            580                 585     


