                         SEQUENCE LISTING

<110>  National Institute of Biological Sciences, Beijing
 
<120>  A molecular glue regulating CDK12-DDB1 interaction to trigger 
       Cyclin K degradation

<130>  RYP2016258.4UC

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  1
gggagcaaac aggattagat accct                                             25


<210>  2
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  prirmer

<400>  2
tgcaccatct gtcactctgt taacctc                                           27


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting NRF2

<400>  3
tatttgactt cagtcagcga                                                   20


<210>  4
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer


<220>
<221>  misc_feature
<222>  (24)..(41)
<223>  n is a, c, g, or t

<400>  4
cctacacgac gctcttccga tctnnnnnnn nnnnnnnnnn ngctttatat atcttgtgga       60

aaggacgaaa cacc                                                         74


<210>  5
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  5
cagacgtgtg ctcttccgat ctccgactcg gtgccacttt ttcaa                       45


<210>  6
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  6
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatct         58


<210>  7
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  7
caagcagaag acggcatacg agatgtgact ggagttcaga cgtgtgctct tccgatct         58


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for DDB1

<400>  8
cattgtcgat atgtgcgtgg                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for DDB1

<400>  9
ctaccaacct gcgatcacca                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for RBX1

<400>  10
agtacactct tctgaagtag                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for RBX1

<400>  11
atggatgtgg ataccccgag                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for UBE2G1

<400>  12
acttactaaa gtgtatctgg                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for UBE2G1

<400>  13
atgaaaagcc agaggaacgc                                                   20


<210>  14
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
gtaaaacgac ggccagtgtt gtcctcgtta tggagaaaga a                           41


<210>  15
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
ctgtgtcttt gtccttggct ttat                                              24


<210>  16
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
gtaaaacgac ggccagt                                                      17


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA for CDK12

<400>  17
gtggacaagt ttgacattat                                                   20


<210>  18
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  single-stranded oligodeoxynucleotides for G731E

<400>  18
ttatatactt ggccataggt tccttctcca ataatttcaa taatgtcaaa cttgtccaca       60

cagcgtttcc cccagtc                                                      77


<210>  19
<211>  77
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  single-stranded oligodeoxynucleotides for G731R

<400>  19
ttatatactt ggccataggt tccttctcca ataatgcgaa taatgtcaaa cttgtccaca       60

cagcgtttcc cccagtc                                                      77


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  20
gcccaattca gagagacatg                                                   20


