                               SEQUENCE LISTING

<110> ACTIVE MOTIF SHANGHAI LIMITED
      FUDAN UNIVERSITY
      SHANGHAI PUBLIC HEALTH CLINICAL CENTER
 
<120> ANTIBODIES AGAINST SARS-COV-2 S1 SPIKE PROTEIN

<130> ACTIVE-012-PCT

<140> PCT/CN2020/094953
<141> 2020-06-08

<160> 61    

<170> PatentIn version 3.5

<210> 1
<211> 366
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 413-2 HCVR1

<400> 1
gaggtgcagc tgttggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcaat aactatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcca taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgacgac acggctgtgt attactgtgc gagagataat      300

aactaccgta actactacta ctacatggac gtctggggca aagggaccac ggtcaccgtc      360

tcctca                                                                 366


<210> 2
<211> 390
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 413-3 HCVR2

<400> 2
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctacgaca tgcactgggt ccgccaagct      120

acaggaaaag gtctggaatg ggtctcagct actggtactg ctggtgacac atactatcca      180

ggctccgtga agggccgatt caccatctcc agagaaaatg ccaagaactc cttgtatctt      240

caaatgaaca gcctgagagc cggggacacg gctgtgtatt actgtgcaag agcggactcc      300

cggggcgatt tttggagtgg ttattaccac tcctactact actactacat ggacgtctgg      360

ggcaaaggga ccacggtcac cgtctcctca                                       390


<210> 3
<211> 354
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-1 HCVR3

<400> 3
caggtgcagc tggtggagtc ggacccagga ctggtgaagc cttcggagac cctgtccctc       60

acccgcactg tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatct attatagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaatc tgaactctgt gaccgccgca gacacggctg tgtattactg tgcgaacttc      300

tacaactatg gaaacgacta ctggggccag ggaaccctgg tcaccgtctc ctca            354


<210> 4
<211> 357
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-3 HCVR4

<400> 4
caggtgcagc aggtgcagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agttatgaaa tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagagatttt      300

atttcccgcc ccaggggtta tcggtggggc cagggaaccc tggtcaccgt ctcctca         357


<210> 5
<211> 357
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-5 HCVR5

<400> 5
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agttatgaaa tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagagatttt      300

atttcccgcc ccaggggtta tcggtggggc cagggaaccc tggtcaccgt ctcctca         357


<210> 6
<211> 375
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 515-5 HCVR6

<400> 6
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgaaactc       60

tcctgtgcag cctctgggtt caccttcagt ggctctgcta tgcactgggt ccgccaggct      120

tccgggaaag ggctggagtg ggttggccgt attagaagca aagctaacag ttacgcgaca      180

gcatatgctg cgtcggtgaa aggcaggttc accatctcca gagatgattc aaagaacacg      240

gcgtatctgc aaatgaacag cctgaaaacc gaggacacgg ccgtgtatta ctgtactaga      300

ggaagtcagt gggctacgat taacgacgcc aggtttgact actggggcca gggaaccctg      360

gtcaccgtct cctca                                                       375


<210> 7
<211> 351
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-13 HCVR7

<400> 7
caggtgcagc tggtgcaatc tggggctgag gtgaagaggc ctgggacctc agtgaaggtt       60

tcctgcaagg catctggata caccttcagt aattactatt tacactgggt gcgacaggcc      120

cctggccaag gacttgagtg ggtgggaata atcgaccccc gcggaggtag gacaagtcac      180

gcacagaagt tacagggaag agtcaccctg accagggaca cgtccacgag cacaggttat      240

atggaattga ggaatctaag gtctgacgac acggccgtgt attactgtgc gagaaccctc      300

agttttgatg atgacgtctg gggccaggga accctggtca ccgtctcctc a               351


<210> 8
<211> 357
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-15 HCVR8

<400> 8
gaggtgcagc tggtgcagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaggtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgttt      240

ctgcaaatga acagtgtgag agccgaggac acggctgtgt acttctgtgc gagagtctgg      300

tattactatg gtccacggga ctactggggc cagggaaccc tggtcaccgt ctcctca         357


<210> 9
<211> 351
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-17 HCVR9

<400> 9
caggtgcagc tgcagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc      120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacacc      180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgatcgc cgcggacacg gctgtgtatt actgtgcgag agccccacag      300

gtagctgcta ttgactactg gggccaggga accctggtca ccgtctcctc a               351


<210> 10
<211> 372
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-18 HCVR10

<400> 10
gaagtgcagc tggtggagtc tgggggaggc ttggtacagc cagggcggtc cctgagactc       60

tcctgtacag cttctggatt cacctttggt gattatgcta tgagctggtt ccgccaggct      120

ccagggaaga ggctggagtg ggtaggtttc attagaagca aagcttatgg tgggacaaca      180

gaatacgccg cgtctgtgaa aggcagattc accatctcaa gagatgattc caaaagcatc      240

gcctatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtactaga      300

atagatgagg gggagcccga atcggggtgg ttcgacccct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210> 11
<211> 360
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-20 HCVR11

<400> 11
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg tttccggata caccctcatt gaattatcca tgcactgggt gcgacaggct      120

cctggaaaag ggcttgagtg gatgggaggt tttgatcctg aagatggtga aacaatctac      180

gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacagcctac      240

atggagctga gcagcctgag atctgttgac acggccgtgt attactgtgc aacagccccc      300

gttcggaggc taggctggtt cgacccctgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 12
<211> 351
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-27 HCVR12

<400> 12
caggtgcagc tggtgcaatc tggggctgag gtgaagaggc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctgggta cagtattacc gggaactata tacagtgggt gcgacaggcc      120

cctggacaag ggctggaatg ggtggggata atcgacccca gtgacggtcg cacaagttac      180

gcagagaagt tgcggggcag agtcactatg accagggaca cgtccaggaa cacagtatat      240

ttggagctga gaagcctgaa atatgaagat acggccgtat atttctgtgg gagaaccctc      300

actgatgact ttgactactg gggccaggga accctggtca ccgtctcctc a               351


<210> 13
<211> 360
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-60 HCVR13

<400> 13
caggtgcagc tggtgcaatc tggggctgag gtgaagaggc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggaga caccttcatc aactatgctt tcagctgggt gcgacaggcc      120

cctgggcaag ggcttgagtg gatgggaagg atcatcccta tccttgatat agcacactac      180

gcacaaaaat tccagggcag acttacgatt accgcggaca agtccacgga cacagcctat      240

atggaactga ccagcctgaa atctgacgac acggccgtat atttctgtgc gagagttttc      300

cgagggagcc aatactggtt cgacccctgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 14
<211> 360
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-63 HCVR14

<400> 14
caggtgcagc tgcaggagtc tggtcctgcg ctggtgaaac ccacacagac cctcacactg       60

acctgcacct tctctgggtt ctcactcagc actagtggaa tgtgtgtgag ctggatccgt      120

cagcccccag ggaaggccct ggagtggctt gcacgcattg attgggatga tgataaatac      180

tacagcacat ctctgaagac caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca cgtattactg tgcacggatg      300

gaggccccaa aattaacgct cgacccctgg ggccagggaa ccctggtcac cgtctcctca      360


<210> 15
<211> 122
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 413-2 HCVR1

<400> 15
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser His Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Asn Tyr Arg Asn Tyr Tyr Tyr Tyr Met Asp Val Trp 
            100                 105                 110         


Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210> 16
<211> 130
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 413-3 HCVR2

<400> 16
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Thr Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Asp Ser Arg Gly Asp Phe Trp Ser Gly Tyr Tyr His Ser Tyr 
            100                 105                 110         


Tyr Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210> 17
<211> 118
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-1 HCVR3

<400> 17
Gln Val Gln Leu Val Glu Ser Asp Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Arg Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Asn Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Asn Phe Tyr Asn Tyr Gly Asn Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210> 18
<211> 119
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-3 HCVR4

<400> 18
Gln Val Gln Gln Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Phe Ile Ser Arg Pro Arg Gly Tyr Arg Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 19
<211> 119
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-5 HCVR5

<400> 19
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Phe Ile Ser Arg Pro Arg Gly Tyr Arg Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 20
<211> 125
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 515-5 HCVR6

<400> 20
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ala Asn Ser Tyr Ala Thr Ala Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Gly Ser Gln Trp Ala Thr Ile Asn Asp Ala Arg Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210> 21
<211> 117
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-13 HCVR7

<400> 21
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asp Pro Arg Gly Gly Arg Thr Ser His Ala Gln Lys Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Thr Ser Thr Ser Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Leu Ser Phe Asp Asp Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 22
<211> 119
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-15 HCVR8

<400> 22
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Gly Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Val Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Trp Tyr Tyr Tyr Gly Pro Arg Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210> 23
<211> 117
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-17 HCVR9

<400> 23
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Thr Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Ile Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Pro Gln Val Ala Ala Ile Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 24
<211> 124
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-18 HCVR10

<400> 24
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Ile Asp Glu Gly Glu Pro Glu Ser Gly Trp Phe Asp 
            100                 105                 110         


Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210> 25
<211> 120
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-20 HCVR11

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Ile Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ala Pro Val Arg Arg Leu Gly Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 26
<211> 117
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-27 HCVR12

<400> 26
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Gly Asn 
            20                  25                  30          


Tyr Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Asp Pro Ser Asp Gly Arg Thr Ser Tyr Ala Glu Lys Leu 
    50                  55                  60                  


Arg Gly Arg Val Thr Met Thr Arg Asp Thr Ser Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Gly Arg Thr Leu Thr Asp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 27
<211> 120
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-60 HCVR13

<400> 27
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ile Asn Tyr 
            20                  25                  30          


Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Asp Ile Ala His Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Ile Thr Ala Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Lys Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Phe Arg Gly Ser Gln Tyr Trp Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 28
<211> 120
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-63 HCVR14

<400> 28
Gln Val Gln Leu Gln Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met Glu Ala Pro Lys Leu Thr Leu Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210> 29
<211> 327
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 413-2 LCVR1

<400> 29
gaaattgtgt tgacacagtc tccaggcacc ctgcctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcc gctcactttc      300

ggcggaggga ccaaggtgga gatcaaa                                          327


<210> 30
<211> 324
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 413-3 LCVR2

<400> 30
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctccgtg gacttttggc      300

caggggacca aggtggaaat caaa                                             324


<210> 31
<211> 333
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-1 LCVR3

<400> 31
caggcagggc tgactcagtc gccctctgcc tctgcctccc tgggagcctc ggtcaagctc       60

acctgcactc tgagcagtgg gcacagcagc tacgccatcg catggcatca gcagcagcca      120

gagaagggcc ctcggtactt gatgaagctt aacagtgatg gcagccacag caagggggac      180

gggatccctg atcgcttctc aggctccagc tctggggctg agcgctacct caccatctcc      240

agcctccagt ctgaggatga ggctgactat tactgtcaga cctgggacac tggcattcag      300

gtgttcggcg gagggaccaa ggtcaccgtc cta                                   333


<210> 32
<211> 336
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-3 LCVR4

<400> 32
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aggcctcgta tacagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcct      300

ccgactttcg gcggagggac caagctggag atcaaa                                336


<210> 33
<211> 336
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-5 LCVR5

<400> 33
gatgttgtga tgacacagtc tccactctcc ctgcccgtca cccttggaca gccggcctcc       60

atctcctgca ggtctagtca aagcctcgta tacagtgatg gaaacaccta cttgaattgg      120

tttcagcaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac      180

tctggggtcc cagacagatt cagcggcagt gggtcaggca ctgatttcac actgaaaatc      240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcct      300

ccgactttcg gcggagggac caaggtggaa atcaaa                                336


<210> 34
<211> 321
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 515-5 LCVR6

<400> 34
gccatccgga tgacccagtc tccatctgcc atgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggcattagc aattatttag cctggtttca gcagaaacca      120

gggaaagtcc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtctacag cataatagtt accctatcac cttcggccaa      300

gggacacgac tggagattaa a                                                321


<210> 35
<211> 324
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-13 LCVR7

<400> 35
gaaatagtga tgacgcagtc tccaggcacc ctgtctttgt ctccagggga tagagccacc       60

ctctcctgta ggaccagtca aagtgttccc aacaactatg tagcctggta ccagcagaaa      120

cctggccaga ctcctaggct cttcatctat gcctcatcca gcagggccac tggcatccca      180

gacaggttcc gtggcggtgg gtctgagaca gacttcactc tcaccatcac tagagtggag      240

cctgaagatt ttgcagtata ctactgtcag cagtatggta gttcaacgta cacttttggc      300

caggggacca aagtggatat caaa                                             324


<210> 36
<211> 336
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-15 LCVR8

<400> 36
gacatcgtga tgacccagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc       60

tcctgcaccc gcagcagtgg cagcattgcc agcaactatg tgcagtggta ccagcagcgc      120

ccgggcagtt cccccaccac tgtgatctat gaggataacc aaagaccctc tggggtccct      180

gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga      240

ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatggcag caatcataat      300

gtggtattcg gcggagggac cgagctgacc gtccta                                336


<210> 37
<211> 333
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-17 LCVR9

<400> 37
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaagcggcc ctcaggggtt      180

tctaatcggt tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caaccagcag cacacatgtg      300

gtattcggcg gagggaccga gctgaccgtc cta                                   333


<210> 38
<211> 336
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-18 LCVR10

<400> 38
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaacccgc      300

ctcactttcg gcggagggac caaggtggag atcaaa                                336


<210> 39
<211> 339
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-20 LCVR11

<400> 39
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgatgttggg agttataacc ttgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca ctaagcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgacaat ctctgggctc      240

caggctgagg acgaggctga ttattactgc tgctcatatg caggtagtag cactttcggt      300

ttttatgtct tcggaactgg gaccaaggtc accgtccta                             339


<210> 40
<211> 324
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-27 LCVR12

<400> 40
gatgttgtga tgactcagtc tccaggcacc ctatctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gactgttagc aacaactact tggcctggta ccagcaaaaa      120

cctggccagg cgcccaaact cctcatctat ggtgcatcca gcagggccgc tggcacccca      180

gacaggttca gtggcggtgg gtctgggaca ggcttcactc tcattatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtctg caatatggtg gctcaacgta cagttttggc      300

caggggacca aggtggagat caaa                                             324


<210> 41
<211> 324
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-60 LCVR13

<400> 41
gaaattgtgt tgacacagtc tccaggcacg ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtattaac aacaggcact tagcctggta ccagcagaaa      120

cgtggccagg cccccaggtt tctcatttat ggtgcagcca gtagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctcc cacgttcggc      300

caagggacca aggtggaaat caaa                                             324


<210> 42
<211> 321
<212> DNA
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-63 LCVR14

<400> 42
gaaatagtga tgacgcagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattcgc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta tccctcggac ttttggcctg      300

gggaccaagc tggagatcaa a                                                321


<210> 43
<211> 109
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 413-2 LCVR1

<400> 43
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Pro Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210> 44
<211> 108
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 413-3 LCVR2

<400> 44
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 45
<211> 111
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-1 LCVR3

<400> 45
Gln Ala Gly Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Leu Asn Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Asp 
                85                  90                  95      


Thr Gly Ile Gln Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210> 46
<211> 112
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-3 LCVR4

<400> 46
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210> 47
<211> 112
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 505-5 LCVR5

<400> 47
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 48
<211> 107
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 515-5 LCVR6

<400> 48
Ala Ile Arg Met Thr Gln Ser Pro Ser Ala Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Val Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210> 49
<211> 108
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-13 LCVR7

<400> 49
Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Asp Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ser Val Pro Asn Asn 
            20                  25                  30          


Tyr Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Thr Pro Arg Leu Phe 
        35                  40                  45              


Ile Tyr Ala Ser Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Arg 
    50                  55                  60                  


Gly Gly Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Thr Arg Val Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Thr 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210> 50
<211> 112
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-15 LCVR8

<400> 50
Asp Ile Val Met Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly 
                85                  90                  95      


Ser Asn His Asn Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 
            100                 105                 110         


<210> 51
<211> 111
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-17 LCVR9

<400> 51
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Thr Ser 
                85                  90                  95      


Ser Thr His Val Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu 
            100                 105                 110     


<210> 52
<211> 112
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-18 LCVR10

<400> 52
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Arg Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210> 53
<211> 113
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-20 LCVR11

<400> 53
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Leu Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Thr Phe Gly Phe Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val 
            100                 105                 110         


Leu 
    


<210> 54
<211> 108
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-27 LCVR12

<400> 54
Asp Val Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Asn Asn 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Ala Gly Thr Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Gly Gly Ser Gly Thr Gly Phe Thr Leu Ile Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Leu Gln Tyr Gly Gly Ser Thr 
                85                  90                  95      


Tyr Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 55
<211> 108
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-60 LCVR13

<400> 55
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Asn Asn Arg 
            20                  25                  30          


His Leu Ala Trp Tyr Gln Gln Lys Arg Gly Gln Ala Pro Arg Phe Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ala Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 56
<211> 107
<212> PRT
<213> Homo sapiens

<220>
<223> Original Clone ID: 553-63 LCVR14

<400> 56
Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ile Pro Arg 
                85                  90                  95      


Thr Phe Gly Leu Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 57
<211> 993
<212> DNA
<213> Homo sapiens

<220>
<223> Heavy Chain Constant Region

<400> 57
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa tga                                   993


<210> 58
<211> 330
<212> PRT
<213> Homo sapiens

<220>
<223> Heavy Chain Constant Region

<400> 58
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 59
<211> 324
<212> DNA
<213> Homo sapiens

<220>
<223> Light Chain Constant Region

<400> 59
cgaacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct       60

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag      120

tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac      180

agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag      240

aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag      300

agcttcaaca ggggagagtg ttag                                             324


<210> 60
<211> 107
<212> PRT
<213> Homo sapiens

<220>
<223> Light Chain Constant Region

<400> 60
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 61
<211> 1273
<212> PRT
<213> Severe acute respiratory syndrome coronavirus 2

<220>
<223> COVID19 Spike Glycoprotein Receptor Binding Domain

<400> 61
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


