                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  COMPOSITIONS AND METHODS FOR EPIGENOME EDITING

<130>  048536-690001WO

<140>  PCT/US21/35937
<141>  2021-06-04

<150>  US 63/118,832
<151>  2020-11-27

<150>  US 63/035,431
<151>  2020-06-05

<160>  120   

<170>  PatentIn version 3.5

<210>  1
<211>  2136
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Arg Ser Arg His Ala Arg Pro Ser Arg Leu Val Arg Lys Glu 
1               5                   10                  15      


Asp Val Asn Lys Lys Lys Lys Asn Ser Gln Leu Arg Lys Thr Thr Lys 
            20                  25                  30          


Gly Ala Asn Lys Asn Val Ala Ser Val Lys Thr Leu Ser Pro Gly Lys 
        35                  40                  45              


Leu Lys Gln Leu Ile Gln Glu Arg Asp Val Lys Lys Lys Thr Glu Pro 
    50                  55                  60                  


Lys Pro Pro Val Pro Val Arg Ser Leu Leu Thr Arg Ala Gly Ala Ala 
65                  70                  75                  80  


Arg Met Asn Leu Asp Arg Thr Glu Val Leu Phe Gln Asn Pro Glu Ser 
                85                  90                  95      


Leu Thr Cys Asn Gly Phe Thr Met Ala Leu Arg Ser Thr Ser Leu Ser 
            100                 105                 110         


Arg Arg Leu Ser Gln Pro Pro Leu Val Val Ala Lys Ser Lys Lys Val 
        115                 120                 125             


Pro Leu Ser Lys Gly Leu Glu Lys Gln His Asp Cys Asp Tyr Lys Ile 
    130                 135                 140                 


Leu Pro Ala Leu Gly Val Lys His Ser Glu Asn Asp Ser Val Pro Met 
145                 150                 155                 160 


Gln Asp Thr Gln Val Leu Pro Asp Ile Glu Thr Leu Ile Gly Val Gln 
                165                 170                 175     


Asn Pro Ser Leu Leu Lys Gly Lys Ser Gln Glu Thr Thr Gln Phe Trp 
            180                 185                 190         


Ser Gln Arg Val Glu Asp Ser Lys Ile Asn Ile Pro Thr His Ser Gly 
        195                 200                 205             


Pro Ala Ala Glu Ile Leu Pro Gly Pro Leu Glu Gly Thr Arg Cys Gly 
    210                 215                 220                 


Glu Gly Leu Phe Ser Glu Glu Thr Leu Asn Asp Thr Ser Gly Ser Pro 
225                 230                 235                 240 


Lys Met Phe Ala Gln Asp Thr Val Cys Ala Pro Phe Pro Gln Arg Ala 
                245                 250                 255     


Thr Pro Lys Val Thr Ser Gln Gly Asn Pro Ser Ile Gln Leu Glu Glu 
            260                 265                 270         


Leu Gly Ser Arg Val Glu Ser Leu Lys Leu Ser Asp Ser Tyr Leu Asp 
        275                 280                 285             


Pro Ile Lys Ser Glu His Asp Cys Tyr Pro Thr Ser Ser Leu Asn Lys 
    290                 295                 300                 


Val Ile Pro Asp Leu Asn Leu Arg Asn Cys Leu Ala Leu Gly Gly Ser 
305                 310                 315                 320 


Thr Ser Pro Thr Ser Val Ile Lys Phe Leu Leu Ala Gly Ser Lys Gln 
                325                 330                 335     


Ala Thr Leu Gly Ala Lys Pro Asp His Gln Glu Ala Phe Glu Ala Thr 
            340                 345                 350         


Ala Asn Gln Gln Glu Val Ser Asp Thr Thr Ser Phe Leu Gly Gln Ala 
        355                 360                 365             


Phe Gly Ala Ile Pro His Gln Trp Glu Leu Pro Gly Ala Asp Pro Val 
    370                 375                 380                 


His Gly Glu Ala Leu Gly Glu Thr Pro Asp Leu Pro Glu Ile Pro Gly 
385                 390                 395                 400 


Ala Ile Pro Val Gln Gly Glu Val Phe Gly Thr Ile Leu Asp Gln Gln 
                405                 410                 415     


Glu Thr Leu Gly Met Ser Gly Ser Val Val Pro Asp Leu Pro Val Phe 
            420                 425                 430         


Leu Pro Val Pro Pro Asn Pro Ile Ala Thr Phe Asn Ala Pro Ser Lys 
        435                 440                 445             


Trp Pro Glu Pro Gln Ser Thr Val Ser Tyr Gly Leu Ala Val Gln Gly 
    450                 455                 460                 


Ala Ile Gln Ile Leu Pro Leu Gly Ser Gly His Thr Pro Gln Ser Ser 
465                 470                 475                 480 


Ser Asn Ser Glu Lys Asn Ser Leu Pro Pro Val Met Ala Ile Ser Asn 
                485                 490                 495     


Val Glu Asn Glu Lys Gln Val His Ile Ser Phe Leu Pro Ala Asn Thr 
            500                 505                 510         


Gln Gly Phe Pro Leu Ala Pro Glu Arg Gly Leu Phe His Ala Ser Leu 
        515                 520                 525             


Gly Ile Ala Gln Leu Ser Gln Ala Gly Pro Ser Lys Ser Asp Arg Gly 
    530                 535                 540                 


Ser Ser Gln Val Ser Val Thr Ser Thr Val His Val Val Asn Thr Thr 
545                 550                 555                 560 


Val Val Thr Met Pro Val Pro Met Val Ser Thr Ser Ser Ser Ser Tyr 
                565                 570                 575     


Thr Thr Leu Leu Pro Thr Leu Glu Lys Lys Lys Arg Lys Arg Cys Gly 
            580                 585                 590         


Val Cys Glu Pro Cys Gln Gln Lys Thr Asn Cys Gly Glu Cys Thr Tyr 
        595                 600                 605             


Cys Lys Asn Arg Lys Asn Ser His Gln Ile Cys Lys Lys Arg Lys Cys 
    610                 615                 620                 


Glu Glu Leu Lys Lys Lys Pro Ser Val Val Val Pro Leu Glu Val Ile 
625                 630                 635                 640 


Lys Glu Asn Lys Arg Pro Gln Arg Glu Lys Lys Pro Lys Val Leu Lys 
                645                 650                 655     


Ala Asp Phe Asp Asn Lys Pro Val Asn Gly Pro Lys Ser Glu Ser Met 
            660                 665                 670         


Asp Tyr Ser Arg Cys Gly His Gly Glu Glu Gln Lys Leu Glu Leu Asn 
        675                 680                 685             


Pro His Thr Val Glu Asn Val Thr Lys Asn Glu Asp Ser Met Thr Gly 
    690                 695                 700                 


Ile Glu Val Glu Lys Trp Thr Gln Asn Lys Lys Ser Gln Leu Thr Asp 
705                 710                 715                 720 


His Val Lys Gly Asp Phe Ser Ala Asn Val Pro Glu Ala Glu Lys Ser 
                725                 730                 735     


Lys Asn Ser Glu Val Asp Lys Lys Arg Thr Lys Ser Pro Lys Leu Phe 
            740                 745                 750         


Val Gln Thr Val Arg Asn Gly Ile Lys His Val His Cys Leu Pro Ala 
        755                 760                 765             


Glu Thr Asn Val Ser Phe Lys Lys Phe Asn Ile Glu Glu Phe Gly Lys 
    770                 775                 780                 


Thr Leu Glu Asn Asn Ser Tyr Lys Phe Leu Lys Asp Thr Ala Asn His 
785                 790                 795                 800 


Lys Asn Ala Met Ser Ser Val Ala Thr Asp Met Ser Cys Asp His Leu 
                805                 810                 815     


Lys Gly Arg Ser Asn Val Leu Val Phe Gln Gln Pro Gly Phe Asn Cys 
            820                 825                 830         


Ser Ser Ile Pro His Ser Ser His Ser Ile Ile Asn His His Ala Ser 
        835                 840                 845             


Ile His Asn Glu Gly Asp Gln Pro Lys Thr Pro Glu Asn Ile Pro Ser 
    850                 855                 860                 


Lys Glu Pro Lys Asp Gly Ser Pro Val Gln Pro Ser Leu Leu Ser Leu 
865                 870                 875                 880 


Met Lys Asp Arg Arg Leu Thr Leu Glu Gln Val Val Ala Ile Glu Ala 
                885                 890                 895     


Leu Thr Gln Leu Ser Glu Ala Pro Ser Glu Asn Ser Ser Pro Ser Lys 
            900                 905                 910         


Ser Glu Lys Asp Glu Glu Ser Glu Gln Arg Thr Ala Ser Leu Leu Asn 
        915                 920                 925             


Ser Cys Lys Ala Ile Leu Tyr Thr Val Arg Lys Asp Leu Gln Asp Pro 
    930                 935                 940                 


Asn Leu Gln Gly Glu Pro Pro Lys Leu Asn His Cys Pro Ser Leu Glu 
945                 950                 955                 960 


Lys Gln Ser Ser Cys Asn Thr Val Val Phe Asn Gly Gln Thr Thr Thr 
                965                 970                 975     


Leu Ser Asn Ser His Ile Asn Ser Ala Thr Asn Gln Ala Ser Thr Lys 
            980                 985                 990         


Ser His Glu Tyr Ser Lys Val Thr  Asn Ser Leu Ser Leu  Phe Ile Pro 
        995                 1000                 1005             


Lys Ser  Asn Ser Ser Lys Ile  Asp Thr Asn Lys Ser  Ile Ala Gln 
    1010                 1015                 1020             


Gly Ile  Ile Thr Leu Asp Asn  Cys Ser Asn Asp Leu  His Gln Leu 
    1025                 1030                 1035             


Pro Pro  Arg Asn Asn Glu Val  Glu Tyr Cys Asn Gln  Leu Leu Asp 
    1040                 1045                 1050             


Ser Ser  Lys Lys Leu Asp Ser  Asp Asp Leu Ser Cys  Gln Asp Ala 
    1055                 1060                 1065             


Thr His  Thr Gln Ile Glu Glu  Asp Val Ala Thr Gln  Leu Thr Gln 
    1070                 1075                 1080             


Leu Ala  Ser Ile Ile Lys Ile  Asn Tyr Ile Lys Pro  Glu Asp Lys 
    1085                 1090                 1095             


Lys Val  Glu Ser Thr Pro Thr  Ser Leu Val Thr Cys  Asn Val Gln 
    1100                 1105                 1110             


Gln Lys  Tyr Asn Gln Glu Lys  Gly Thr Ile Gln Gln  Lys Pro Pro 
    1115                 1120                 1125             


Ser Ser  Val His Asn Asn His  Gly Ser Ser Leu Thr  Lys Gln Lys 
    1130                 1135                 1140             


Asn Pro  Thr Gln Lys Lys Thr  Lys Ser Thr Pro Ser  Arg Asp Arg 
    1145                 1150                 1155             


Arg Lys  Lys Lys Pro Thr Val  Val Ser Tyr Gln Glu  Asn Asp Arg 
    1160                 1165                 1170             


Gln Lys  Trp Glu Lys Leu Ser  Tyr Met Tyr Gly Thr  Ile Cys Asp 
    1175                 1180                 1185             


Ile Trp  Ile Ala Ser Lys Phe  Gln Asn Phe Gly Gln  Phe Cys Pro 
    1190                 1195                 1200             


His Asp  Phe Pro Thr Val Phe  Gly Lys Ile Ser Ser  Ser Thr Lys 
    1205                 1210                 1215             


Ile Trp  Lys Pro Leu Ala Gln  Thr Arg Ser Ile Met  Gln Pro Lys 
    1220                 1225                 1230             


Thr Val  Phe Pro Pro Leu Thr  Gln Ile Lys Leu Gln  Arg Tyr Pro 
    1235                 1240                 1245             


Glu Ser  Ala Glu Glu Lys Val  Lys Val Glu Pro Leu  Asp Ser Leu 
    1250                 1255                 1260             


Ser Leu  Phe His Leu Lys Thr  Glu Ser Asn Gly Lys  Ala Phe Thr 
    1265                 1270                 1275             


Asp Lys  Ala Tyr Asn Ser Gln  Val Gln Leu Thr Val  Asn Ala Asn 
    1280                 1285                 1290             


Gln Lys  Ala His Pro Leu Thr  Gln Pro Ser Ser Pro  Pro Asn Gln 
    1295                 1300                 1305             


Cys Ala  Asn Val Met Ala Gly  Asp Asp Gln Ile Arg  Phe Gln Gln 
    1310                 1315                 1320             


Val Val  Lys Glu Gln Leu Met  His Gln Arg Leu Pro  Thr Leu Pro 
    1325                 1330                 1335             


Gly Ile  Ser His Glu Thr Pro  Leu Pro Glu Ser Ala  Leu Thr Leu 
    1340                 1345                 1350             


Arg Asn  Val Asn Val Val Cys  Ser Gly Gly Ile Thr  Val Val Ser 
    1355                 1360                 1365             


Thr Lys  Ser Glu Glu Glu Val  Cys Ser Ser Ser Phe  Gly Thr Ser 
    1370                 1375                 1380             


Glu Phe  Ser Thr Val Asp Ser  Ala Gln Lys Asn Phe  Asn Asp Tyr 
    1385                 1390                 1395             


Ala Met  Asn Phe Phe Thr Asn  Pro Thr Lys Asn Leu  Val Ser Ile 
    1400                 1405                 1410             


Thr Lys  Asp Ser Glu Leu Pro  Thr Cys Ser Cys Leu  Asp Arg Val 
    1415                 1420                 1425             


Ile Gln  Lys Asp Lys Gly Pro  Tyr Tyr Thr His Leu  Gly Ala Gly 
    1430                 1435                 1440             


Pro Ser  Val Ala Ala Val Arg  Glu Ile Met Glu Asn  Arg Tyr Gly 
    1445                 1450                 1455             


Gln Lys  Gly Asn Ala Ile Arg  Ile Glu Ile Val Val  Tyr Thr Gly 
    1460                 1465                 1470             


Lys Glu  Gly Lys Ser Ser His  Gly Cys Pro Ile Ala  Lys Trp Val 
    1475                 1480                 1485             


Leu Arg  Arg Ser Ser Asp Glu  Glu Lys Val Leu Cys  Leu Val Arg 
    1490                 1495                 1500             


Gln Arg  Thr Gly His His Cys  Pro Thr Ala Val Met  Val Val Leu 
    1505                 1510                 1515             


Ile Met  Val Trp Asp Gly Ile  Pro Leu Pro Met Ala  Asp Arg Leu 
    1520                 1525                 1530             


Tyr Thr  Glu Leu Thr Glu Asn  Leu Lys Ser Tyr Asn  Gly His Pro 
    1535                 1540                 1545             


Thr Asp  Arg Arg Cys Thr Leu  Asn Glu Asn Arg Thr  Cys Thr Cys 
    1550                 1555                 1560             


Gln Gly  Ile Asp Pro Glu Thr  Cys Gly Ala Ser Phe  Ser Phe Gly 
    1565                 1570                 1575             


Cys Ser  Trp Ser Met Tyr Phe  Asn Gly Cys Lys Phe  Gly Arg Ser 
    1580                 1585                 1590             


Pro Ser  Pro Arg Arg Phe Arg  Ile Asp Pro Ser Ser  Pro Leu His 
    1595                 1600                 1605             


Glu Lys  Asn Leu Glu Asp Asn  Leu Gln Ser Leu Ala  Thr Arg Leu 
    1610                 1615                 1620             


Ala Pro  Ile Tyr Lys Gln Tyr  Ala Pro Val Ala Tyr  Gln Asn Gln 
    1625                 1630                 1635             


Val Glu  Tyr Glu Asn Val Ala  Arg Glu Cys Arg Leu  Gly Ser Lys 
    1640                 1645                 1650             


Glu Gly  Arg Pro Phe Ser Gly  Val Thr Ala Cys Leu  Asp Phe Cys 
    1655                 1660                 1665             


Ala His  Pro His Arg Asp Ile  His Asn Met Asn Asn  Gly Ser Thr 
    1670                 1675                 1680             


Val Val  Cys Thr Leu Thr Arg  Glu Asp Asn Arg Ser  Leu Gly Val 
    1685                 1690                 1695             


Ile Pro  Gln Asp Glu Gln Leu  His Val Leu Pro Leu  Tyr Lys Leu 
    1700                 1705                 1710             


Ser Asp  Thr Asp Glu Phe Gly  Ser Lys Glu Gly Met  Glu Ala Lys 
    1715                 1720                 1725             


Ile Lys  Ser Gly Ala Ile Glu  Val Leu Ala Pro Arg  Arg Lys Lys 
    1730                 1735                 1740             


Arg Thr  Cys Phe Thr Gln Pro  Val Pro Arg Ser Gly  Lys Lys Arg 
    1745                 1750                 1755             


Ala Ala  Met Met Thr Glu Val  Leu Ala His Lys Ile  Arg Ala Val 
    1760                 1765                 1770             


Glu Lys  Lys Pro Ile Pro Arg  Ile Lys Arg Lys Asn  Asn Ser Thr 
    1775                 1780                 1785             


Thr Thr  Asn Asn Ser Lys Pro  Ser Ser Leu Pro Thr  Leu Gly Ser 
    1790                 1795                 1800             


Asn Thr  Glu Thr Val Gln Pro  Glu Val Lys Ser Glu  Thr Glu Pro 
    1805                 1810                 1815             


His Phe  Ile Leu Lys Ser Ser  Asp Asn Thr Lys Thr  Tyr Ser Leu 
    1820                 1825                 1830             


Met Pro  Ser Ala Pro His Pro  Val Lys Glu Ala Ser  Pro Gly Phe 
    1835                 1840                 1845             


Ser Trp  Ser Pro Lys Thr Ala  Ser Ala Thr Pro Ala  Pro Leu Lys 
    1850                 1855                 1860             


Asn Asp  Ala Thr Ala Ser Cys  Gly Phe Ser Glu Arg  Ser Ser Thr 
    1865                 1870                 1875             


Pro His  Cys Thr Met Pro Ser  Gly Arg Leu Ser Gly  Ala Asn Ala 
    1880                 1885                 1890             


Ala Ala  Ala Asp Gly Pro Gly  Ile Ser Gln Leu Gly  Glu Val Ala 
    1895                 1900                 1905             


Pro Leu  Pro Thr Leu Ser Ala  Pro Val Met Glu Pro  Leu Ile Asn 
    1910                 1915                 1920             


Ser Glu  Pro Ser Thr Gly Val  Thr Glu Pro Leu Thr  Pro His Gln 
    1925                 1930                 1935             


Pro Asn  His Gln Pro Ser Phe  Leu Thr Ser Pro Gln  Asp Leu Ala 
    1940                 1945                 1950             


Ser Ser  Pro Met Glu Glu Asp  Glu Gln His Ser Glu  Ala Asp Glu 
    1955                 1960                 1965             


Pro Pro  Ser Asp Glu Pro Leu  Ser Asp Asp Pro Leu  Ser Pro Ala 
    1970                 1975                 1980             


Glu Glu  Lys Leu Pro His Ile  Asp Glu Tyr Trp Ser  Asp Ser Glu 
    1985                 1990                 1995             


His Ile  Phe Leu Asp Ala Asn  Ile Gly Gly Val Ala  Ile Ala Pro 
    2000                 2005                 2010             


Ala His  Gly Ser Val Leu Ile  Glu Cys Ala Arg Arg  Glu Leu His 
    2015                 2020                 2025             


Ala Thr  Thr Pro Val Glu His  Pro Asn Arg Asn His  Pro Thr Arg 
    2030                 2035                 2040             


Leu Ser  Leu Val Phe Tyr Gln  His Lys Asn Leu Asn  Lys Pro Gln 
    2045                 2050                 2055             


His Gly  Phe Glu Leu Asn Lys  Ile Lys Phe Glu Ala  Lys Glu Ala 
    2060                 2065                 2070             


Lys Asn  Lys Lys Met Lys Ala  Ser Glu Gln Lys Asp  Gln Ala Ala 
    2075                 2080                 2085             


Asn Glu  Gly Pro Glu Gln Ser  Ser Glu Val Asn Glu  Leu Asn Gln 
    2090                 2095                 2100             


Ile Pro  Ser His Lys Ala Leu  Thr Leu Thr His Asp  Asn Val Val 
    2105                 2110                 2115             


Thr Val  Ser Pro Tyr Ala Leu  Thr His Val Ala Gly  Pro Tyr Asn 
    2120                 2125                 2130             


His Trp  Val 
    2135     


<210>  2
<211>  1942
<212>  PRT
<213>  Homo sapiens

<400>  2

Tyr Gly Ile Pro Cys Met Lys Gly Ser Gln Asn Ser Arg Val Ser Pro 
1               5                   10                  15      


Asp Phe Thr Gln Glu Ser Arg Gly Tyr Ser Lys Cys Leu Gln Asn Gly 
            20                  25                  30          


Gly Ile Lys Arg Thr Val Ser Glu Pro Ser Leu Ser Gly Leu Leu Gln 
        35                  40                  45              


Ile Lys Lys Leu Lys Gln Asp Gln Lys Ala Asn Gly Glu Arg Arg Asn 
    50                  55                  60                  


Phe Gly Val Ser Gln Glu Arg Asn Pro Gly Glu Ser Ser Gln Pro Asn 
65                  70                  75                  80  


Val Ser Asp Leu Ser Asp Lys Lys Glu Ser Val Ser Ser Val Ala Gln 
                85                  90                  95      


Glu Asn Ala Val Lys Asp Phe Thr Ser Phe Ser Thr His Asn Cys Ser 
            100                 105                 110         


Gly Pro Glu Asn Pro Glu Leu Gln Ile Leu Asn Glu Gln Glu Gly Lys 
        115                 120                 125             


Ser Ala Asn Tyr His Asp Lys Asn Ile Val Leu Leu Lys Asn Lys Ala 
    130                 135                 140                 


Val Leu Met Pro Asn Gly Ala Thr Val Ser Ala Ser Ser Val Glu His 
145                 150                 155                 160 


Thr His Gly Glu Leu Leu Glu Lys Thr Leu Ser Gln Tyr Tyr Pro Asp 
                165                 170                 175     


Cys Val Ser Ile Ala Val Gln Lys Thr Thr Ser His Ile Asn Ala Ile 
            180                 185                 190         


Asn Ser Gln Ala Thr Asn Glu Leu Ser Cys Glu Ile Thr His Pro Ser 
        195                 200                 205             


His Thr Ser Gly Gln Ile Asn Ser Ala Gln Thr Ser Asn Ser Glu Leu 
    210                 215                 220                 


Pro Pro Lys Pro Ala Ala Val Val Ser Glu Ala Cys Asp Ala Asp Asp 
225                 230                 235                 240 


Ala Asp Asn Ala Ser Lys Leu Ala Ala Met Leu Asn Thr Cys Ser Phe 
                245                 250                 255     


Gln Lys Pro Glu Gln Leu Gln Gln Gln Lys Ser Val Phe Glu Ile Cys 
            260                 265                 270         


Pro Ser Pro Ala Glu Asn Asn Ile Gln Gly Thr Thr Lys Leu Ala Ser 
        275                 280                 285             


Gly Glu Glu Phe Cys Ser Gly Ser Ser Ser Asn Leu Gln Ala Pro Gly 
    290                 295                 300                 


Gly Ser Ser Glu Arg Tyr Leu Lys Gln Asn Glu Met Asn Gly Ala Tyr 
305                 310                 315                 320 


Phe Lys Gln Ser Ser Val Phe Thr Lys Asp Ser Phe Ser Ala Thr Thr 
                325                 330                 335     


Thr Pro Pro Pro Pro Ser Gln Leu Leu Leu Ser Pro Pro Pro Pro Leu 
            340                 345                 350         


Pro Gln Val Pro Gln Leu Pro Ser Glu Gly Lys Ser Thr Leu Asn Gly 
        355                 360                 365             


Gly Val Leu Glu Glu His His His Tyr Pro Asn Gln Ser Asn Thr Thr 
    370                 375                 380                 


Leu Leu Arg Glu Val Lys Ile Glu Gly Lys Pro Glu Ala Pro Pro Ser 
385                 390                 395                 400 


Gln Ser Pro Asn Pro Ser Thr His Val Cys Ser Pro Ser Pro Met Leu 
                405                 410                 415     


Ser Glu Arg Pro Gln Asn Asn Cys Val Asn Arg Asn Asp Ile Gln Thr 
            420                 425                 430         


Ala Gly Thr Met Thr Val Pro Leu Cys Ser Glu Lys Thr Arg Pro Met 
        435                 440                 445             


Ser Glu His Leu Lys His Asn Pro Pro Ile Phe Gly Ser Ser Gly Glu 
    450                 455                 460                 


Leu Gln Asp Asn Cys Gln Gln Leu Met Arg Asn Lys Glu Gln Glu Ile 
465                 470                 475                 480 


Leu Lys Gly Arg Asp Lys Glu Gln Thr Arg Asp Leu Val Pro Pro Thr 
                485                 490                 495     


Gln His Tyr Leu Lys Pro Gly Trp Ile Glu Leu Lys Ala Pro Arg Phe 
            500                 505                 510         


His Gln Ala Glu Ser His Leu Lys Arg Asn Glu Ala Ser Leu Pro Ser 
        515                 520                 525             


Ile Leu Gln Tyr Gln Pro Asn Leu Ser Asn Gln Met Thr Ser Lys Gln 
    530                 535                 540                 


Tyr Thr Gly Asn Ser Asn Met Pro Gly Gly Leu Pro Arg Gln Ala Tyr 
545                 550                 555                 560 


Thr Gln Lys Thr Thr Gln Leu Glu His Lys Ser Gln Met Tyr Gln Val 
                565                 570                 575     


Glu Met Asn Gln Gly Gln Ser Gln Gly Thr Val Asp Gln His Leu Gln 
            580                 585                 590         


Phe Gln Lys Pro Ser His Gln Val His Phe Ser Lys Thr Asp His Leu 
        595                 600                 605             


Pro Lys Ala His Val Gln Ser Leu Cys Gly Thr Arg Phe His Phe Gln 
    610                 615                 620                 


Gln Arg Ala Asp Ser Gln Thr Glu Lys Leu Met Ser Pro Val Leu Lys 
625                 630                 635                 640 


Gln His Leu Asn Gln Gln Ala Ser Glu Thr Glu Pro Phe Ser Asn Ser 
                645                 650                 655     


His Leu Leu Gln His Lys Pro His Lys Gln Ala Ala Gln Thr Gln Pro 
            660                 665                 670         


Ser Gln Ser Ser His Leu Pro Gln Asn Gln Gln Gln Gln Gln Lys Leu 
        675                 680                 685             


Gln Ile Lys Asn Lys Glu Glu Ile Leu Gln Thr Phe Pro His Pro Gln 
    690                 695                 700                 


Ser Asn Asn Asp Gln Gln Arg Glu Gly Ser Phe Phe Gly Gln Thr Lys 
705                 710                 715                 720 


Val Glu Glu Cys Phe His Gly Glu Asn Gln Tyr Ser Lys Ser Ser Glu 
                725                 730                 735     


Phe Glu Thr His Asn Val Gln Met Gly Leu Glu Glu Val Gln Asn Ile 
            740                 745                 750         


Asn Arg Arg Asn Ser Pro Tyr Ser Gln Thr Met Lys Ser Ser Ala Cys 
        755                 760                 765             


Lys Ile Gln Val Ser Cys Ser Asn Asn Thr His Leu Val Ser Glu Asn 
    770                 775                 780                 


Lys Glu Gln Thr Thr His Pro Glu Leu Phe Ala Gly Asn Lys Thr Gln 
785                 790                 795                 800 


Asn Leu His His Met Gln Tyr Phe Pro Asn Asn Val Ile Pro Lys Gln 
                805                 810                 815     


Asp Leu Leu His Arg Cys Phe Gln Glu Gln Glu Gln Lys Ser Gln Gln 
            820                 825                 830         


Ala Ser Val Leu Gln Gly Tyr Lys Asn Arg Asn Gln Asp Met Ser Gly 
        835                 840                 845             


Gln Gln Ala Ala Gln Leu Ala Gln Gln Arg Tyr Leu Ile His Asn His 
    850                 855                 860                 


Ala Asn Val Phe Pro Val Pro Asp Gln Gly Gly Ser His Thr Gln Thr 
865                 870                 875                 880 


Pro Pro Gln Lys Asp Thr Gln Lys His Ala Ala Leu Arg Trp His Leu 
                885                 890                 895     


Leu Gln Lys Gln Glu Gln Gln Gln Thr Gln Gln Pro Gln Thr Glu Ser 
            900                 905                 910         


Cys His Ser Gln Met His Arg Pro Ile Lys Val Glu Pro Gly Cys Lys 
        915                 920                 925             


Pro His Ala Cys Met His Thr Ala Pro Pro Glu Asn Lys Thr Trp Lys 
    930                 935                 940                 


Lys Val Thr Lys Gln Glu Asn Pro Pro Ala Ser Cys Asp Asn Val Gln 
945                 950                 955                 960 


Gln Lys Ser Ile Ile Glu Thr Met Glu Gln His Leu Lys Gln Phe His 
                965                 970                 975     


Ala Lys Ser Leu Phe Asp His Lys Ala Leu Thr Leu Lys Ser Gln Lys 
            980                 985                 990         


Gln Val Lys Val Glu Met Ser Gly  Pro Val Thr Val Leu  Thr Arg Gln 
        995                 1000                 1005             


Thr Thr  Ala Ala Glu Leu Asp  Ser His Thr Pro Ala  Leu Glu Gln 
    1010                 1015                 1020             


Gln Thr  Thr Ser Ser Glu Lys  Thr Pro Thr Lys Arg  Thr Ala Ala 
    1025                 1030                 1035             


Ser Val  Leu Asn Asn Phe Ile  Glu Ser Pro Ser Lys  Leu Leu Asp 
    1040                 1045                 1050             


Thr Pro  Ile Lys Asn Leu Leu  Asp Thr Pro Val Lys  Thr Gln Tyr 
    1055                 1060                 1065             


Asp Phe  Pro Ser Cys Arg Cys  Val Glu Gln Ile Ile  Glu Lys Asp 
    1070                 1075                 1080             


Glu Gly  Pro Phe Tyr Thr His  Leu Gly Ala Gly Pro  Asn Val Ala 
    1085                 1090                 1095             


Ala Ile  Arg Glu Ile Met Glu  Glu Arg Phe Gly Gln  Lys Gly Lys 
    1100                 1105                 1110             


Ala Ile  Arg Ile Glu Arg Val  Ile Tyr Thr Gly Lys  Glu Gly Lys 
    1115                 1120                 1125             


Ser Ser  Gln Gly Cys Pro Ile  Ala Lys Trp Val Val  Arg Arg Ser 
    1130                 1135                 1140             


Ser Ser  Glu Glu Lys Leu Leu  Cys Leu Val Arg Glu  Arg Ala Gly 
    1145                 1150                 1155             


His Thr  Cys Glu Ala Ala Val  Ile Val Ile Leu Ile  Leu Val Trp 
    1160                 1165                 1170             


Glu Gly  Ile Pro Leu Ser Leu  Ala Asp Lys Leu Tyr  Ser Glu Leu 
    1175                 1180                 1185             


Thr Glu  Thr Leu Arg Lys Tyr  Gly Thr Leu Thr Asn  Arg Arg Cys 
    1190                 1195                 1200             


Ala Leu  Asn Glu Glu Arg Thr  Cys Ala Cys Gln Gly  Leu Asp Pro 
    1205                 1210                 1215             


Glu Thr  Cys Gly Ala Ser Phe  Ser Phe Gly Cys Ser  Trp Ser Met 
    1220                 1225                 1230             


Tyr Tyr  Asn Gly Cys Lys Phe  Ala Arg Ser Lys Ile  Pro Arg Lys 
    1235                 1240                 1245             


Phe Lys  Leu Leu Gly Asp Asp  Pro Lys Glu Glu Glu  Lys Leu Glu 
    1250                 1255                 1260             


Ser His  Leu Gln Asn Leu Ser  Thr Leu Met Ala Pro  Thr Tyr Lys 
    1265                 1270                 1275             


Lys Leu  Ala Pro Asp Ala Tyr  Asn Asn Gln Ile Glu  Tyr Glu His 
    1280                 1285                 1290             


Arg Ala  Pro Glu Cys Arg Leu  Gly Leu Lys Glu Gly  Arg Pro Phe 
    1295                 1300                 1305             


Ser Gly  Val Thr Ala Cys Leu  Asp Phe Cys Ala His  Ala His Arg 
    1310                 1315                 1320             


Asp Leu  His Asn Met Gln Asn  Gly Ser Thr Leu Val  Cys Thr Leu 
    1325                 1330                 1335             


Thr Arg  Glu Asp Asn Arg Glu  Phe Gly Gly Lys Pro  Glu Asp Glu 
    1340                 1345                 1350             


Gln Leu  His Val Leu Pro Leu  Tyr Lys Val Ser Asp  Val Asp Glu 
    1355                 1360                 1365             


Phe Gly  Ser Val Glu Ala Gln  Glu Glu Lys Lys Arg  Ser Gly Ala 
    1370                 1375                 1380             


Ile Gln  Val Leu Ser Ser Phe  Arg Arg Lys Val Arg  Met Leu Ala 
    1385                 1390                 1395             


Glu Pro  Val Lys Thr Cys Arg  Gln Arg Lys Leu Glu  Ala Lys Lys 
    1400                 1405                 1410             


Ala Ala  Ala Glu Lys Leu Ser  Ser Leu Glu Asn Ser  Ser Asn Lys 
    1415                 1420                 1425             


Asn Glu  Lys Glu Lys Ser Ala  Pro Ser Arg Thr Lys  Gln Thr Glu 
    1430                 1435                 1440             


Asn Ala  Ser Gln Ala Lys Gln  Leu Ala Glu Leu Leu  Arg Leu Ser 
    1445                 1450                 1455             


Gly Pro  Val Met Gln Gln Ser  Gln Gln Pro Gln Pro  Leu Gln Lys 
    1460                 1465                 1470             


Gln Pro  Pro Gln Pro Gln Gln  Gln Gln Arg Pro Gln  Gln Gln Gln 
    1475                 1480                 1485             


Pro His  His Pro Gln Thr Glu  Ser Val Asn Ser Tyr  Ser Ala Ser 
    1490                 1495                 1500             


Gly Ser  Thr Asn Pro Tyr Met  Arg Arg Pro Asn Pro  Val Ser Pro 
    1505                 1510                 1515             


Tyr Pro  Asn Ser Ser His Thr  Ser Asp Ile Tyr Gly  Ser Thr Ser 
    1520                 1525                 1530             


Pro Met  Asn Phe Tyr Ser Thr  Ser Ser Gln Ala Ala  Gly Ser Tyr 
    1535                 1540                 1545             


Leu Asn  Ser Ser Asn Pro Met  Asn Pro Tyr Pro Gly  Leu Leu Asn 
    1550                 1555                 1560             


Gln Asn  Thr Gln Tyr Pro Ser  Tyr Gln Cys Asn Gly  Asn Leu Ser 
    1565                 1570                 1575             


Val Asp  Asn Cys Ser Pro Tyr  Leu Gly Ser Tyr Ser  Pro Gln Ser 
    1580                 1585                 1590             


Gln Pro  Met Asp Leu Tyr Arg  Tyr Pro Ser Gln Asp  Pro Leu Ser 
    1595                 1600                 1605             


Lys Leu  Ser Leu Pro Pro Ile  His Thr Leu Tyr Gln  Pro Arg Phe 
    1610                 1615                 1620             


Gly Asn  Ser Gln Ser Phe Thr  Ser Lys Tyr Leu Gly  Tyr Gly Asn 
    1625                 1630                 1635             


Gln Asn  Met Gln Gly Asp Gly  Phe Ser Ser Cys Thr  Ile Arg Pro 
    1640                 1645                 1650             


Asn Val  His His Val Gly Lys  Leu Pro Pro Tyr Pro  Thr His Glu 
    1655                 1660                 1665             


Met Asp  Gly His Phe Met Gly  Ala Thr Ser Arg Leu  Pro Pro Asn 
    1670                 1675                 1680             


Leu Ser  Asn Pro Asn Met Asp  Tyr Lys Asn Gly Glu  His His Ser 
    1685                 1690                 1695             


Pro Ser  His Ile Ile His Asn  Tyr Ser Ala Ala Pro  Gly Met Phe 
    1700                 1705                 1710             


Asn Ser  Ser Leu His Ala Leu  His Leu Gln Asn Lys  Glu Asn Asp 
    1715                 1720                 1725             


Met Leu  Ser His Thr Ala Asn  Gly Leu Ser Lys Met  Leu Pro Ala 
    1730                 1735                 1740             


Leu Asn  His Asp Arg Thr Ala  Cys Val Gln Gly Gly  Leu His Lys 
    1745                 1750                 1755             


Leu Ser  Asp Ala Asn Gly Gln  Glu Lys Gln Pro Leu  Ala Leu Val 
    1760                 1765                 1770             


Gln Gly  Val Ala Ser Gly Ala  Glu Asp Asn Asp Glu  Val Trp Ser 
    1775                 1780                 1785             


Asp Ser  Glu Gln Ser Phe Leu  Asp Pro Asp Ile Gly  Gly Val Ala 
    1790                 1795                 1800             


Val Ala  Pro Thr His Gly Ser  Ile Leu Ile Glu Cys  Ala Lys Arg 
    1805                 1810                 1815             


Glu Leu  His Ala Thr Thr Pro  Leu Lys Asn Pro Asn  Arg Asn His 
    1820                 1825                 1830             


Pro Thr  Arg Ile Ser Leu Val  Phe Tyr Gln His Lys  Ser Met Asn 
    1835                 1840                 1845             


Glu Pro  Lys His Gly Leu Ala  Leu Trp Glu Ala Lys  Met Ala Glu 
    1850                 1855                 1860             


Lys Ala  Arg Glu Lys Glu Glu  Glu Cys Glu Lys Tyr  Gly Pro Asp 
    1865                 1870                 1875             


Tyr Val  Pro Gln Lys Ser His  Gly Lys Lys Val Lys  Arg Glu Pro 
    1880                 1885                 1890             


Ala Glu  Pro His Glu Thr Ser  Glu Pro Thr Tyr Leu  Arg Phe Ile 
    1895                 1900                 1905             


Lys Ser  Leu Ala Glu Arg Thr  Met Ser Val Thr Thr  Asp Ser Thr 
    1910                 1915                 1920             


Val Thr  Thr Ser Pro Tyr Ala  Phe Thr Arg Val Thr  Gly Pro Tyr 
    1925                 1930                 1935             


Asn Arg  Tyr Ile 
    1940         


<210>  3
<211>  1795
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Gln Phe Gln Val Pro Leu Ala Val Gln Pro Asp Leu Pro Gly 
1               5                   10                  15      


Leu Tyr Asp Phe Pro Gln Arg Gln Val Met Val Gly Ser Phe Pro Gly 
            20                  25                  30          


Ser Gly Leu Ser Met Ala Gly Ser Glu Ser Gln Leu Arg Gly Gly Gly 
        35                  40                  45              


Asp Gly Arg Lys Lys Arg Lys Arg Cys Gly Thr Cys Glu Pro Cys Arg 
    50                  55                  60                  


Arg Leu Glu Asn Cys Gly Ala Cys Thr Ser Cys Thr Asn Arg Arg Thr 
65                  70                  75                  80  


His Gln Ile Cys Lys Leu Arg Lys Cys Glu Val Leu Lys Lys Lys Val 
                85                  90                  95      


Gly Leu Leu Lys Glu Val Glu Ile Lys Ala Gly Glu Gly Ala Gly Pro 
            100                 105                 110         


Trp Gly Gln Gly Ala Ala Val Lys Thr Gly Ser Glu Leu Ser Pro Val 
        115                 120                 125             


Asp Gly Pro Val Pro Gly Gln Met Asp Ser Gly Pro Val Tyr His Gly 
    130                 135                 140                 


Asp Ser Arg Gln Leu Ser Ala Ser Gly Val Pro Val Asn Gly Ala Arg 
145                 150                 155                 160 


Glu Pro Ala Gly Pro Ser Leu Leu Gly Thr Gly Gly Pro Trp Arg Val 
                165                 170                 175     


Asp Gln Lys Pro Asp Trp Glu Ala Ala Pro Gly Pro Ala His Thr Ala 
            180                 185                 190         


Arg Leu Glu Asp Ala His Asp Leu Val Ala Phe Ser Ala Val Ala Glu 
        195                 200                 205             


Ala Val Ser Ser Tyr Gly Ala Leu Ser Thr Arg Leu Tyr Glu Thr Phe 
    210                 215                 220                 


Asn Arg Glu Met Ser Arg Glu Ala Gly Asn Asn Ser Arg Gly Pro Arg 
225                 230                 235                 240 


Pro Gly Pro Glu Gly Cys Ser Ala Gly Ser Glu Asp Leu Asp Thr Leu 
                245                 250                 255     


Gln Thr Ala Leu Ala Leu Ala Arg His Gly Met Lys Pro Pro Asn Cys 
            260                 265                 270         


Asn Cys Asp Gly Pro Glu Cys Pro Asp Tyr Leu Glu Trp Leu Glu Gly 
        275                 280                 285             


Lys Ile Lys Ser Val Val Met Glu Gly Gly Glu Glu Arg Pro Arg Leu 
    290                 295                 300                 


Pro Gly Pro Leu Pro Pro Gly Glu Ala Gly Leu Pro Ala Pro Ser Thr 
305                 310                 315                 320 


Arg Pro Leu Leu Ser Ser Glu Val Pro Gln Ile Ser Pro Gln Glu Gly 
                325                 330                 335     


Leu Pro Leu Ser Gln Ser Ala Leu Ser Ile Ala Lys Glu Lys Asn Ile 
            340                 345                 350         


Ser Leu Gln Thr Ala Ile Ala Ile Glu Ala Leu Thr Gln Leu Ser Ser 
        355                 360                 365             


Ala Leu Pro Gln Pro Ser His Ser Thr Pro Gln Ala Ser Cys Pro Leu 
    370                 375                 380                 


Pro Glu Ala Leu Ser Pro Pro Ala Pro Phe Arg Ser Pro Gln Ser Tyr 
385                 390                 395                 400 


Leu Arg Ala Pro Ser Trp Pro Val Val Pro Pro Glu Glu His Ser Ser 
                405                 410                 415     


Phe Ala Pro Asp Ser Ser Ala Phe Pro Pro Ala Thr Pro Arg Thr Glu 
            420                 425                 430         


Phe Pro Glu Ala Trp Gly Thr Asp Thr Pro Pro Ala Thr Pro Arg Ser 
        435                 440                 445             


Ser Trp Pro Met Pro Arg Pro Ser Pro Asp Pro Met Ala Glu Leu Glu 
    450                 455                 460                 


Gln Leu Leu Gly Ser Ala Ser Asp Tyr Ile Gln Ser Val Phe Lys Arg 
465                 470                 475                 480 


Pro Glu Ala Leu Pro Thr Lys Pro Lys Val Lys Val Glu Ala Pro Ser 
                485                 490                 495     


Ser Ser Pro Ala Pro Ala Pro Ser Pro Val Leu Gln Arg Glu Ala Pro 
            500                 505                 510         


Thr Pro Ser Ser Glu Pro Asp Thr His Gln Lys Ala Gln Thr Ala Leu 
        515                 520                 525             


Gln Gln His Leu His His Lys Arg Ser Leu Phe Leu Glu Gln Val His 
    530                 535                 540                 


Asp Thr Ser Phe Pro Ala Pro Ser Glu Pro Ser Ala Pro Gly Trp Trp 
545                 550                 555                 560 


Pro Pro Pro Ser Ser Pro Val Pro Arg Leu Pro Asp Arg Pro Pro Lys 
                565                 570                 575     


Glu Lys Lys Lys Lys Leu Pro Thr Pro Ala Gly Gly Pro Val Gly Thr 
            580                 585                 590         


Glu Lys Ala Ala Pro Gly Ile Lys Pro Ser Val Arg Lys Pro Ile Gln 
        595                 600                 605             


Ile Lys Lys Ser Arg Pro Arg Glu Ala Gln Pro Leu Phe Pro Pro Val 
    610                 615                 620                 


Arg Gln Ile Val Leu Glu Gly Leu Arg Ser Pro Ala Ser Gln Glu Val 
625                 630                 635                 640 


Gln Ala His Pro Pro Ala Pro Leu Pro Ala Ser Gln Gly Ser Ala Val 
                645                 650                 655     


Pro Leu Pro Pro Glu Pro Ser Leu Ala Leu Phe Ala Pro Ser Pro Ser 
            660                 665                 670         


Arg Asp Ser Leu Leu Pro Pro Thr Gln Glu Met Arg Ser Pro Ser Pro 
        675                 680                 685             


Met Thr Ala Leu Gln Pro Gly Ser Thr Gly Pro Leu Pro Pro Ala Asp 
    690                 695                 700                 


Asp Lys Leu Glu Glu Leu Ile Arg Gln Phe Glu Ala Glu Phe Gly Asp 
705                 710                 715                 720 


Ser Phe Gly Leu Pro Gly Pro Pro Ser Val Pro Ile Gln Asp Pro Glu 
                725                 730                 735     


Asn Gln Gln Thr Cys Leu Pro Ala Pro Glu Ser Pro Phe Ala Thr Arg 
            740                 745                 750         


Ser Pro Lys Gln Ile Lys Ile Glu Ser Ser Gly Ala Val Thr Val Leu 
        755                 760                 765             


Ser Thr Thr Cys Phe His Ser Glu Glu Gly Gly Gln Glu Ala Thr Pro 
    770                 775                 780                 


Thr Lys Ala Glu Asn Pro Leu Thr Pro Thr Leu Ser Gly Phe Leu Glu 
785                 790                 795                 800 


Ser Pro Leu Lys Tyr Leu Asp Thr Pro Thr Lys Ser Leu Leu Asp Thr 
                805                 810                 815     


Pro Ala Lys Arg Ala Gln Ala Glu Phe Pro Thr Cys Asp Cys Val Glu 
            820                 825                 830         


Gln Ile Val Glu Lys Asp Glu Gly Pro Tyr Tyr Thr His Leu Gly Ser 
        835                 840                 845             


Gly Pro Thr Val Ala Ser Ile Arg Glu Leu Met Glu Glu Arg Tyr Gly 
    850                 855                 860                 


Glu Lys Gly Lys Ala Ile Arg Ile Glu Lys Val Ile Tyr Thr Gly Lys 
865                 870                 875                 880 


Glu Gly Lys Ser Ser Arg Gly Cys Pro Ile Ala Lys Trp Val Ile Arg 
                885                 890                 895     


Arg His Thr Leu Glu Glu Lys Leu Leu Cys Leu Val Arg His Arg Ala 
            900                 905                 910         


Gly His His Cys Gln Asn Ala Val Ile Val Ile Leu Ile Leu Ala Trp 
        915                 920                 925             


Glu Gly Ile Pro Arg Ser Leu Gly Asp Thr Leu Tyr Gln Glu Leu Thr 
    930                 935                 940                 


Asp Thr Leu Arg Lys Tyr Gly Asn Pro Thr Ser Arg Arg Cys Gly Leu 
945                 950                 955                 960 


Asn Asp Asp Arg Thr Cys Ala Cys Gln Gly Lys Asp Pro Asn Thr Cys 
                965                 970                 975     


Gly Ala Ser Phe Ser Phe Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly 
            980                 985                 990         


Cys Lys Tyr Ala Arg Ser Lys Thr  Pro Arg Lys Phe Arg  Leu Ala Gly 
        995                 1000                 1005             


Asp Asn  Pro Lys Glu Glu Glu  Val Leu Arg Lys Ser  Phe Gln Asp 
    1010                 1015                 1020             


Leu Ala  Thr Glu Val Ala Pro  Leu Tyr Lys Arg Leu  Ala Pro Gln 
    1025                 1030                 1035             


Ala Tyr  Gln Asn Gln Val Thr  Asn Glu Glu Ile Ala  Ile Asp Cys 
    1040                 1045                 1050             


Arg Leu  Gly Leu Lys Glu Gly  Arg Pro Phe Ala Gly  Val Thr Ala 
    1055                 1060                 1065             


Cys Met  Asp Phe Cys Ala His  Ala His Lys Asp Gln  His Asn Leu 
    1070                 1075                 1080             


Tyr Asn  Gly Cys Thr Val Val  Cys Thr Leu Thr Lys  Glu Asp Asn 
    1085                 1090                 1095             


Arg Cys  Val Gly Lys Ile Pro  Glu Asp Glu Gln Leu  His Val Leu 
    1100                 1105                 1110             


Pro Leu  Tyr Lys Met Ala Asn  Thr Asp Glu Phe Gly  Ser Glu Glu 
    1115                 1120                 1125             


Asn Gln  Asn Ala Lys Val Gly  Ser Gly Ala Ile Gln  Val Leu Thr 
    1130                 1135                 1140             


Ala Phe  Pro Arg Glu Val Arg  Arg Leu Pro Glu Pro  Ala Lys Ser 
    1145                 1150                 1155             


Cys Arg  Gln Arg Gln Leu Glu  Ala Arg Lys Ala Ala  Ala Glu Lys 
    1160                 1165                 1170             


Lys Lys  Ile Gln Lys Glu Lys  Leu Ser Thr Pro Glu  Lys Ile Lys 
    1175                 1180                 1185             


Gln Glu  Ala Leu Glu Leu Ala  Gly Ile Thr Ser Asp  Pro Gly Leu 
    1190                 1195                 1200             


Ser Leu  Lys Gly Gly Leu Ser  Gln Gln Gly Leu Lys  Pro Ser Leu 
    1205                 1210                 1215             


Lys Val  Glu Pro Gln Asn His  Phe Ser Ser Phe Lys  Tyr Ser Gly 
    1220                 1225                 1230             


Asn Ala  Val Val Glu Ser Tyr  Ser Val Leu Gly Asn  Cys Arg Pro 
    1235                 1240                 1245             


Ser Asp  Pro Tyr Ser Met Asn  Ser Val Tyr Ser Tyr  His Ser Tyr 
    1250                 1255                 1260             


Tyr Ala  Gln Pro Ser Leu Thr  Ser Val Asn Gly Phe  His Ser Lys 
    1265                 1270                 1275             


Tyr Ala  Leu Pro Ser Phe Ser  Tyr Tyr Gly Phe Pro  Ser Ser Asn 
    1280                 1285                 1290             


Pro Val  Phe Pro Ser Gln Phe  Leu Gly Pro Gly Ala  Trp Gly His 
    1295                 1300                 1305             


Ser Gly  Ser Ser Gly Ser Phe  Glu Lys Lys Pro Asp  Leu His Ala 
    1310                 1315                 1320             


Leu His  Asn Ser Leu Ser Pro  Ala Tyr Gly Gly Ala  Glu Phe Ala 
    1325                 1330                 1335             


Glu Leu  Pro Ser Gln Ala Val  Pro Thr Asp Ala His  His Pro Thr 
    1340                 1345                 1350             


Pro His  His Gln Gln Pro Ala  Tyr Pro Gly Pro Lys  Glu Tyr Leu 
    1355                 1360                 1365             


Leu Pro  Lys Ala Pro Leu Leu  His Ser Val Ser Arg  Asp Pro Ser 
    1370                 1375                 1380             


Pro Phe  Ala Gln Ser Ser Asn  Cys Tyr Asn Arg Ser  Ile Lys Gln 
    1385                 1390                 1395             


Glu Pro  Val Asp Pro Leu Thr  Gln Ala Glu Pro Val  Pro Arg Asp 
    1400                 1405                 1410             


Ala Gly  Lys Met Gly Lys Thr  Pro Leu Ser Glu Val  Ser Gln Asn 
    1415                 1420                 1425             


Gly Gly  Pro Ser His Leu Trp  Gly Gln Tyr Ser Gly  Gly Pro Ser 
    1430                 1435                 1440             


Met Ser  Pro Lys Arg Thr Asn  Gly Val Gly Gly Ser  Trp Gly Val 
    1445                 1450                 1455             


Phe Ser  Ser Gly Glu Ser Pro  Ala Ile Val Pro Asp  Lys Leu Ser 
    1460                 1465                 1470             


Ser Phe  Gly Ala Ser Cys Leu  Ala Pro Ser His Phe  Thr Asp Gly 
    1475                 1480                 1485             


Gln Trp  Gly Leu Phe Pro Gly  Glu Gly Gln Gln Ala  Ala Ser His 
    1490                 1495                 1500             


Ser Gly  Gly Arg Leu Arg Gly  Lys Pro Trp Ser Pro  Cys Lys Phe 
    1505                 1510                 1515             


Gly Asn  Ser Thr Ser Ala Leu  Ala Gly Pro Ser Leu  Thr Glu Lys 
    1520                 1525                 1530             


Pro Trp  Ala Leu Gly Ala Gly  Asp Phe Asn Ser Ala  Leu Lys Gly 
    1535                 1540                 1545             


Ser Pro  Gly Phe Gln Asp Lys  Leu Trp Asn Pro Met  Lys Gly Glu 
    1550                 1555                 1560             


Glu Gly  Arg Ile Pro Ala Ala  Gly Ala Ser Gln Leu  Asp Arg Ala 
    1565                 1570                 1575             


Trp Gln  Ser Phe Gly Leu Pro  Leu Gly Ser Ser Glu  Lys Leu Phe 
    1580                 1585                 1590             


Gly Ala  Leu Lys Ser Glu Glu  Lys Leu Trp Asp Pro  Phe Ser Leu 
    1595                 1600                 1605             


Glu Glu  Gly Pro Ala Glu Glu  Pro Pro Ser Lys Gly  Ala Val Lys 
    1610                 1615                 1620             


Glu Glu  Lys Gly Gly Gly Gly  Ala Glu Glu Glu Glu  Glu Glu Leu 
    1625                 1630                 1635             


Trp Ser  Asp Ser Glu His Asn  Phe Leu Asp Glu Asn  Ile Gly Gly 
    1640                 1645                 1650             


Val Ala  Val Ala Pro Ala His  Gly Ser Ile Leu Ile  Glu Cys Ala 
    1655                 1660                 1665             


Arg Arg  Glu Leu His Ala Thr  Thr Pro Leu Lys Lys  Pro Asn Arg 
    1670                 1675                 1680             


Cys His  Pro Thr Arg Ile Ser  Leu Val Phe Tyr Gln  His Lys Asn 
    1685                 1690                 1695             


Leu Asn  Gln Pro Asn His Gly  Leu Ala Leu Trp Glu  Ala Lys Met 
    1700                 1705                 1710             


Lys Gln  Leu Ala Glu Arg Ala  Arg Ala Arg Gln Glu  Glu Ala Ala 
    1715                 1720                 1725             


Arg Leu  Gly Leu Gly Gln Gln  Glu Ala Lys Leu Tyr  Gly Lys Lys 
    1730                 1735                 1740             


Arg Lys  Trp Gly Gly Thr Val  Val Ala Glu Pro Gln  Gln Lys Glu 
    1745                 1750                 1755             


Lys Lys  Gly Val Val Pro Thr  Arg Gln Ala Leu Ala  Val Pro Thr 
    1760                 1765                 1770             


Asp Ser  Ala Val Thr Val Ser  Ser Tyr Ala Tyr Thr  Lys Val Thr 
    1775                 1780                 1785             


Gly Pro  Tyr Ser Arg Trp Ile  
    1790                 1795 


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
1               5                   10                  15      


<210>  6
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser Pro Ala 
1               5                   10                  15      


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
            20                  25                  30          


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
        35                  40                  45              


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 
    50                  55                  60                  


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 
65                  70                  75                  80  


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  8
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu Gly 
1               5                   10                  15      


Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly Lys 
            20                  25                  30          


Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly Gly 
        35                  40                  45              


Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr Gly 
    50                  55                  60                  


Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe Lys 
65                  70                  75                  80  


Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr Glu 
                85                  90                  95      


Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly 
            100                 105                 110         


Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser Asn 
        115                 120                 125             


Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr Glu 
    130                 135                 140                 


Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met Ala 
145                 150                 155                 160 


Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr Thr 
                165                 170                 175     


Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val Tyr 
            180                 185                 190         


Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu Thr 
        195                 200                 205             


Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu Pro 
    210                 215                 220                 


Ser Lys Leu Gly His Lys Leu Asn 
225                 230         


<210>  9
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  10
<211>  1307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Ala Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  11
<211>  1228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Ala 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Ala Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  12
<211>  1314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Gly Ser Gly Met Ser 
1               5                   10                  15      


Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr Leu Arg 
            20                  25                  30          


Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys Ala Arg 
        35                  40                  45              


Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys Lys Ala 
    50                  55                  60                  


Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu Ile Leu 
65                  70                  75                  80  


Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser Asp Val 
                85                  90                  95      


Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys Asp Phe 
            100                 105                 110         


Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr Ile Lys 
        115                 120                 125             


Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile Asp Ala 
    130                 135                 140                 


Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln Ser Lys 
145                 150                 155                 160 


Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr Asp Ile 
                165                 170                 175     


Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr Thr Tyr 
            180                 185                 190         


Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser Asn Asp 
        195                 200                 205             


Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu Pro Lys 
    210                 215                 220                 


Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys Ala Pro 
225                 230                 235                 240 


Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu Glu Leu 
                245                 250                 255     


Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg Val Phe 
            260                 265                 270         


Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr Leu Asn 
        275                 280                 285             


Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys Phe Val 
    290                 295                 300                 


Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile Asn Leu 
305                 310                 315                 320 


Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys Met Ser 
                325                 330                 335     


Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser Phe Val 
            340                 345                 350         


Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met Gln Ser 
        355                 360                 365             


Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys Ser Ile 
    370                 375                 380                 


Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln Lys Leu 
385                 390                 395                 400 


Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr Asp Leu 
                405                 410                 415     


Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala Val Leu 
            420                 425                 430         


Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn Pro Ser 
        435                 440                 445             


Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala Lys Tyr 
    450                 455                 460                 


Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn Lys His 
465                 470                 475                 480 


Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala Asn Phe 
                485                 490                 495     


Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys Asp Asn 
            500                 505                 510         


Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys Asp Leu 
        515                 520                 525             


Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp Leu Leu 
    530                 535                 540                 


Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His Ile Ser 
545                 550                 555                 560 


Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His Phe Tyr 
                565                 570                 575     


Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val Pro Leu 
            580                 585                 590         


Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser Asp Glu 
        595                 600                 605             


Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly Trp Asp 
    610                 615                 620                 


Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys Asp Asp 
625                 630                 635                 640 


Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile Phe Asp 
                645                 650                 655     


Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys Ile Val 
            660                 665                 670         


Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Phe 
        675                 680                 685             


Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile Leu Arg 
    690                 695                 700                 


Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln Lys Gly 
705                 710                 715                 720 


Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe Ile Asp 
                725                 730                 735     


Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp Phe Gly 
            740                 745                 750         


Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu Phe Tyr 
        755                 760                 765             


Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn Ile Ser 
    770                 775                 780                 


Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr Leu Phe 
785                 790                 795                 800 


Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg Pro Asn 
                805                 810                 815     


Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn Leu Gln 
            820                 825                 830         


Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr Arg Lys 
        835                 840                 845             


Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala Ile Ala 
    850                 855                 860                 


Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu Tyr Asp 
865                 870                 875                 880 


Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe His Cys 
                885                 890                 895     


Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe Asn Asp 
            900                 905                 910         


Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His Ile Leu 
        915                 920                 925             


Ser Ile Ala Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu Val Asp 
    930                 935                 940                 


Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile Gly Asn 
945                 950                 955                 960 


Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile Glu Lys 
                965                 970                 975     


Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn Ile Lys 
            980                 985                 990         


Glu Met Lys Glu Gly Tyr Leu Ser  Gln Val Val His Glu  Ile Ala Lys 
        995                 1000                 1005             


Leu Val  Ile Glu Tyr Asn Ala  Ile Val Val Phe Glu  Asp Leu Asn 
    1010                 1015                 1020             


Phe Gly  Phe Lys Arg Gly Arg  Phe Lys Val Glu Lys  Gln Val Tyr 
    1025                 1030                 1035             


Gln Lys  Leu Glu Lys Met Leu  Ile Glu Lys Leu Asn  Tyr Leu Val 
    1040                 1045                 1050             


Phe Lys  Asp Asn Glu Phe Asp  Lys Thr Gly Gly Val  Leu Arg Ala 
    1055                 1060                 1065             


Tyr Gln  Leu Thr Ala Pro Phe  Glu Thr Phe Lys Lys  Met Gly Lys 
    1070                 1075                 1080             


Gln Thr  Gly Ile Ile Tyr Tyr  Val Pro Ala Gly Phe  Thr Ser Lys 
    1085                 1090                 1095             


Ile Cys  Pro Val Thr Gly Phe  Val Asn Gln Leu Tyr  Pro Lys Tyr 
    1100                 1105                 1110             


Glu Ser  Val Ser Lys Ser Gln  Glu Phe Phe Ser Lys  Phe Asp Lys 
    1115                 1120                 1125             


Ile Cys  Tyr Asn Leu Asp Lys  Gly Tyr Phe Glu Phe  Ser Phe Asp 
    1130                 1135                 1140             


Tyr Lys  Asn Phe Gly Asp Lys  Ala Ala Lys Gly Lys  Trp Thr Ile 
    1145                 1150                 1155             


Ala Ser  Phe Gly Ser Arg Leu  Ile Asn Phe Arg Asn  Ser Asp Lys 
    1160                 1165                 1170             


Asn His  Asn Trp Asp Thr Arg  Glu Val Tyr Pro Thr  Lys Glu Leu 
    1175                 1180                 1185             


Glu Lys  Leu Leu Lys Asp Tyr  Ser Ile Glu Tyr Gly  His Gly Glu 
    1190                 1195                 1200             


Cys Ile  Lys Ala Ala Ile Cys  Gly Glu Ser Asp Lys  Lys Phe Phe 
    1205                 1210                 1215             


Ala Lys  Leu Thr Ser Val Leu  Asn Thr Ile Leu Gln  Met Arg Asn 
    1220                 1225                 1230             


Ser Lys  Thr Gly Thr Glu Leu  Asp Tyr Leu Ile Ser  Pro Val Ala 
    1235                 1240                 1245             


Asp Val  Asn Gly Asn Phe Phe  Asp Ser Arg Gln Ala  Pro Lys Asn 
    1250                 1255                 1260             


Met Pro  Gln Asp Ala Asp Ala  Asn Gly Ala Tyr His  Ile Gly Leu 
    1265                 1270                 1275             


Lys Gly  Leu Met Leu Leu Gly  Arg Ile Lys Asn Asn  Gln Glu Gly 
    1280                 1285                 1290             


Lys Lys  Leu Asn Leu Val Ile  Lys Asn Glu Glu Tyr  Phe Glu Phe 
    1295                 1300                 1305             


Val Gln  Asn Arg Asn Asn 
    1310                 


<210>  13
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asp Glu Leu Phe Pro Leu Ile Phe Pro Ala Glu Pro Ala Gln Ala 
1               5                   10                  15      


Ser Gly Pro Tyr Val Glu Ile Ile Glu Gln Pro Lys Gln Arg Gly Met 
            20                  25                  30          


Arg Phe Arg Tyr Lys Cys Glu Gly Arg Ser Ala Gly Ser Ile Pro Gly 
        35                  40                  45              


Glu Arg Ser Thr Asp Thr Thr Lys Thr His Pro Thr Ile Lys Ile Asn 
    50                  55                  60                  


Gly Tyr Thr Gly Pro Gly Thr Val Arg Ile Ser Leu Val Thr Lys Asp 
65                  70                  75                  80  


Pro Pro His Arg Pro His Pro His Glu Leu Val Gly Lys Asp Cys Arg 
                85                  90                  95      


Asp Gly Phe Tyr Glu Ala Glu Leu Cys Pro Asp Arg Cys Ile His Ser 
            100                 105                 110         


Phe Gln Asn Leu Gly Ile Gln Cys Val Lys Lys Arg Asp Leu Glu Gln 
        115                 120                 125             


Ala Ile Ser Gln Arg Ile Gln Thr Asn Asn Asn Pro Phe Gln Val Pro 
    130                 135                 140                 


Ile Glu Glu Gln Arg Gly Asp Tyr Asp Leu Asn Ala Val Arg Leu Cys 
145                 150                 155                 160 


Phe Gln Val Thr Val Arg Asp Pro Ser Gly Arg Pro Leu Arg Leu Pro 
                165                 170                 175     


Pro Val Leu Ser His Pro Ile Phe Asp Asn Arg Ala Pro Asn Thr Ala 
            180                 185                 190         


Glu Leu Lys Ile Cys Arg Val Asn Arg Asn Ser Gly Ser Cys Leu Gly 
        195                 200                 205             


Gly Asp Glu Ile Phe Leu Leu Cys Asp Lys Val Gln Lys Glu Asp Ile 
    210                 215                 220                 


Glu Val Tyr Phe Thr Gly Pro Gly Trp Glu Ala Arg Gly Ser Phe Ser 
225                 230                 235                 240 


Gln Ala Asp Val His Arg Gln Val Ala Ile Val Phe Arg Thr Pro Pro 
                245                 250                 255     


Tyr Ala Asp Pro Ser Leu Gln Ala Pro Val Arg Val Ser Met Gln Leu 
            260                 265                 270         


Arg Arg Pro Ser Asp Arg Glu Leu Ser Glu Pro Met Glu Phe Gln Tyr 
        275                 280                 285             


Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg 
    290                 295                 300                 


Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly 
305                 310                 315                 320 


Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg 
                325                 330                 335     


Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr 
            340                 345                 350         


Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe 
        355                 360                 365             


Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro 
    370                 375                 380                 


Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val 
385                 390                 395                 400 


Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly 
                405                 410                 415     


Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly 
            420                 425                 430         


Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu 
        435                 440                 445             


Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr 
    450                 455                 460                 


Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln 
465                 470                 475                 480 


Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr 
                485                 490                 495     


Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp 
            500                 505                 510         


Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu 
        515                 520                 525             


Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala 
    530                 535                 540                 


Leu Leu Ser Gln Ile Ser Ser 
545                 550     


<210>  14
<211>  119
<212>  PRT
<213>  Pan paniscus

<400>  14

Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu 
1               5                   10                  15      


Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp 
            20                  25                  30          


Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln 
        35                  40                  45              


Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro 
    50                  55                  60                  


Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala 
65                  70                  75                  80  


Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu 
                85                  90                  95      


Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp 
            100                 105                 110         


Met Asp Phe Ser Ala Leu Leu 
        115                 


<210>  15
<211>  190
<212>  PRT
<213>  Human gammaherpesvirus 4

<400>  15

Arg Asp Ser Arg Glu Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser 
1               5                   10                  15      


Ala Ile Ser Asp Val Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg 
            20                  25                  30          


Ile Arg Pro Phe His Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu 
        35                  40                  45              


Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val 
    50                  55                  60                  


Gly Ser Leu Thr Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro 
65                  70                  75                  80  


Ala Val Thr Pro Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu 
                85                  90                  95      


Thr Ser Gln Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile 
            100                 105                 110         


Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His 
        115                 120                 125             


Pro Pro Pro Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser 
    130                 135                 140                 


Met Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn 
145                 150                 155                 160 


Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met 
                165                 170                 175     


His Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr Ser Leu Phe 
            180                 185                 190 


<210>  16
<211>  605
<212>  PRT
<213>  Human gammaherpesvirus 4

<400>  16

Met Arg Pro Lys Lys Asp Gly Leu Glu Asp Phe Leu Arg Leu Thr Pro 
1               5                   10                  15      


Glu Ile Lys Lys Gln Leu Gly Ser Leu Val Ser Asp Tyr Cys Asn Val 
            20                  25                  30          


Leu Asn Lys Glu Phe Thr Ala Gly Ser Val Glu Ile Thr Leu Arg Ser 
        35                  40                  45              


Tyr Lys Ile Cys Lys Ala Phe Ile Asn Glu Ala Lys Ala His Gly Arg 
    50                  55                  60                  


Glu Trp Gly Gly Leu Met Ala Thr Leu Asn Ile Cys Asn Phe Trp Ala 
65                  70                  75                  80  


Ile Leu Arg Asn Asn Arg Val Arg Arg Arg Ala Glu Asn Ala Gly Asn 
                85                  90                  95      


Asp Ala Cys Ser Ile Ala Cys Pro Ile Val Met Arg Tyr Val Leu Asp 
            100                 105                 110         


His Leu Ile Val Val Thr Asp Arg Phe Phe Ile Gln Ala Pro Ser Asn 
        115                 120                 125             


Arg Val Met Ile Pro Ala Thr Ile Gly Thr Ala Met Tyr Lys Leu Leu 
    130                 135                 140                 


Lys His Ser Arg Val Arg Ala Tyr Thr Tyr Ser Lys Val Leu Gly Val 
145                 150                 155                 160 


Asp Arg Ala Ala Ile Met Ala Ser Gly Lys Gln Val Val Glu His Leu 
                165                 170                 175     


Asn Arg Met Glu Lys Glu Gly Leu Leu Ser Ser Lys Phe Lys Ala Phe 
            180                 185                 190         


Cys Lys Trp Val Phe Thr Tyr Pro Val Leu Glu Glu Met Phe Gln Thr 
        195                 200                 205             


Met Val Ser Ser Lys Thr Gly His Leu Thr Asp Asp Val Lys Asp Val 
    210                 215                 220                 


Arg Ala Leu Ile Lys Thr Leu Pro Arg Ala Ser Tyr Ser Ser His Ala 
225                 230                 235                 240 


Gly Gln Arg Ser Tyr Val Ser Gly Val Leu Pro Ala Cys Leu Leu Ser 
                245                 250                 255     


Thr Lys Ser Lys Ala Val Glu Thr Pro Ile Leu Val Ser Gly Ala Asp 
            260                 265                 270         


Arg Met Asp Glu Glu Leu Met Gly Asn Asp Gly Gly Ala Ser His Thr 
        275                 280                 285             


Glu Ala Arg Tyr Ser Glu Ser Gly Gln Phe His Ala Phe Thr Asp Glu 
    290                 295                 300                 


Leu Glu Ser Leu Pro Ser Pro Thr Met Pro Leu Lys Pro Gly Ala Gln 
305                 310                 315                 320 


Ser Ala Asp Cys Gly Asp Ser Ser Ser Ser Ser Ser Asp Ser Gly Asn 
                325                 330                 335     


Ser Asp Thr Glu Gln Ser Glu Arg Glu Glu Ala Arg Ala Glu Ala Pro 
            340                 345                 350         


Arg Leu Arg Ala Pro Lys Ser Arg Arg Thr Ser Arg Pro Asn Arg Gly 
        355                 360                 365             


Gln Thr Pro Cys Pro Ser Asn Ala Ala Glu Pro Glu Gln Pro Trp Ile 
    370                 375                 380                 


Ala Ala Val His Gln Glu Ser Asp Glu Arg Pro Ile Phe Pro His Pro 
385                 390                 395                 400 


Ser Lys Pro Thr Phe Leu Pro Pro Val Lys Arg Lys Lys Gly Leu Arg 
                405                 410                 415     


Asp Ser Arg Glu Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala 
            420                 425                 430         


Ile Ser Asp Val Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile 
        435                 440                 445             


Arg Pro Phe His Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro 
    450                 455                 460                 


Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val Gly 
465                 470                 475                 480 


Ser Leu Thr Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala 
                485                 490                 495     


Val Thr Pro Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr 
            500                 505                 510         


Ser Gln Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro 
        515                 520                 525             


Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro 
    530                 535                 540                 


Pro Pro Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met 
545                 550                 555                 560 


Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu 
                565                 570                 575     


Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met His 
            580                 585                 590         


Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr Ser Leu Phe 
        595                 600                 605 


<210>  17
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
1               5                   10                  15      


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            20                  25                  30          


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        35                  40                  45              


Met Leu 
    50  


<210>  18
<211>  490
<212>  PRT
<213>  Human herpesvirus 1

<400>  18

Met Asp Leu Leu Val Asp Glu Leu Phe Ala Asp Met Asn Ala Asp Gly 
1               5                   10                  15      


Ala Ser Pro Pro Pro Pro Arg Pro Ala Gly Gly Pro Lys Asn Thr Pro 
            20                  25                  30          


Ala Ala Pro Pro Leu Tyr Ala Thr Gly Arg Leu Ser Gln Ala Gln Leu 
        35                  40                  45              


Met Pro Ser Pro Pro Met Pro Val Pro Pro Ala Ala Leu Phe Asn Arg 
    50                  55                  60                  


Leu Leu Asp Asp Leu Gly Phe Ser Ala Gly Pro Ala Leu Cys Thr Met 
65                  70                  75                  80  


Leu Asp Thr Trp Asn Glu Asp Leu Phe Ser Ala Leu Pro Thr Asn Ala 
                85                  90                  95      


Asp Leu Tyr Arg Glu Cys Lys Phe Leu Ser Thr Leu Pro Ser Asp Val 
            100                 105                 110         


Val Glu Trp Gly Asp Ala Tyr Val Pro Glu Arg Thr Gln Ile Asp Ile 
        115                 120                 125             


Arg Ala His Gly Asp Val Ala Phe Pro Thr Leu Pro Ala Thr Arg Asp 
    130                 135                 140                 


Gly Leu Gly Leu Tyr Tyr Glu Ala Leu Ser Arg Phe Phe His Ala Glu 
145                 150                 155                 160 


Leu Arg Ala Arg Glu Glu Ser Tyr Arg Thr Val Leu Ala Asn Phe Cys 
                165                 170                 175     


Ser Ala Leu Tyr Arg Tyr Leu Arg Ala Ser Val Arg Gln Leu His Arg 
            180                 185                 190         


Gln Ala His Met Arg Gly Arg Asp Arg Asp Leu Gly Glu Met Leu Arg 
        195                 200                 205             


Ala Thr Ile Ala Asp Arg Tyr Tyr Arg Glu Thr Ala Arg Leu Ala Arg 
    210                 215                 220                 


Val Leu Phe Leu His Leu Tyr Leu Phe Leu Thr Arg Glu Ile Leu Trp 
225                 230                 235                 240 


Ala Ala Tyr Ala Glu Gln Met Met Arg Pro Asp Leu Phe Asp Cys Leu 
                245                 250                 255     


Cys Cys Asp Leu Glu Ser Trp Arg Gln Leu Ala Gly Leu Phe Gln Pro 
            260                 265                 270         


Phe Met Phe Val Asn Gly Ala Leu Thr Val Arg Gly Val Pro Ile Glu 
        275                 280                 285             


Ala Arg Arg Leu Arg Glu Leu Asn His Ile Arg Glu His Leu Asn Leu 
    290                 295                 300                 


Pro Leu Val Arg Ser Ala Ala Thr Glu Glu Pro Gly Ala Pro Leu Thr 
305                 310                 315                 320 


Thr Pro Pro Thr Leu His Gly Asn Gln Ala Arg Ala Ser Gly Tyr Phe 
                325                 330                 335     


Met Val Leu Ile Arg Ala Lys Leu Asp Ser Tyr Ser Ser Phe Thr Thr 
            340                 345                 350         


Ser Pro Ser Glu Ala Val Met Arg Glu His Ala Tyr Ser Arg Ala Arg 
        355                 360                 365             


Thr Lys Asn Asn Tyr Gly Ser Thr Ile Glu Gly Leu Leu Asp Leu Pro 
    370                 375                 380                 


Asp Asp Asp Ala Pro Glu Glu Ala Gly Leu Ala Ala Pro Arg Leu Ser 
385                 390                 395                 400 


Phe Leu Pro Ala Gly His Thr Arg Arg Leu Ser Thr Ala Pro Pro Thr 
                405                 410                 415     


Asp Val Ser Leu Gly Asp Glu Leu His Leu Asp Gly Glu Asp Val Ala 
            420                 425                 430         


Met Ala His Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
        435                 440                 445             


Asp Gly Asp Ser Pro Gly Pro Gly Phe Thr Pro His Asp Ser Ala Pro 
    450                 455                 460                 


Tyr Gly Ala Leu Asp Met Ala Asp Phe Glu Phe Glu Gln Met Phe Thr 
465                 470                 475                 480 


Asp Ala Leu Gly Ile Asp Glu Tyr Gly Gly 
                485                 490 


<210>  19
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  19
agccaacatg aggatcaccc atgtctgcag ggc                                    33


<210>  20
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  20
ggccaacatg aggatcaccc atgtctgcag ggcc                                   34


<210>  21
<211>  130
<212>  PRT
<213>  Bacteriophage MS2

<400>  21

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr 
    130 


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
actgcggaaa tttgagcgt                                                    19


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
acgctcaaat ttccgcagt                                                    19


<210>  24
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
aggcaatggc tgcacatgc                                                    19


<210>  25
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
gcatgtgcag ccattgcct                                                    19


<210>  26
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
gacgcttggt tctgaggag                                                    19


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
ctcctcagaa ccaagcgtc                                                    19


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
tccggaaacg cattcctct                                                    19


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
agaggaatgc gtttccgga                                                    19


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
ccgcgtcagc ccggcccgg                                                    19


<210>  31
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  31
ccgggccggg ctgacgcgg                                                    19


<210>  32
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  32
cgactcccgc tgggcctct                                                    19


<210>  33
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  33
agaggcccag cgggagtcg                                                    19


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  34
ccgttgcgcg ctcgctctc                                                    19


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  35
gagagcgagc gcgcaacgg                                                    19


<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  36
ccgcgcatcc tgccaggcc                                                    19


<210>  37
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  37
actgcggaaa tttgagcgt                                                    19


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  38
acgcucaaau uuccgcagu                                                    19


<210>  39
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  39
aggcaatggc tgcacatgc                                                    19


<210>  40
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  40
gcaugugcag ccauugccu                                                    19


<210>  41
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  41
gacgcttggt tctgaggag                                                    19


<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  42
cuccucagaa ccaagcguc                                                    19


<210>  43
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  43
tccggaaacg cattcctct                                                    19


<210>  44
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  44
agaggaaugc guuuccgga                                                    19


<210>  45
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  45
ccgcgtcagc ccggcccgg                                                    19


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  46
ccgggccggg cugacgcgg                                                    19


<210>  47
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  47
cgactcccgc tgggcctct                                                    19


<210>  48
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  48
agaggcccag cgggagucg                                                    19


<210>  49
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  49
ccgttgcgcg ctcgctctc                                                    19


<210>  50
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  50
gagagcgagc gcgcaacgg                                                    19


<210>  51
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  51
ccgcgcatcc tgccaggcc                                                    19


<210>  52
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  52
ggccuggcag gaugcgcgg                                                    19


<210>  53
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  53
ccaacttggc gcgtttcgg                                                    19


<210>  54
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  54
ccgaaacgcg ccaaguugg                                                    19


<210>  55
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  55
accacgcgtc cgagtccgg                                                    19


<210>  56
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  56
ccggacucgg acgcguggu                                                    19


<210>  57
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  57
tgctcattgt ccctggaca                                                    19


<210>  58
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  58
uguccaggga caaugagca                                                    19


<210>  59
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  59
ggacaccctg ctcattgtc                                                    19


<210>  60
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  60
gacaaugagc agggugucc                                                    19


<210>  61
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  61
accggcagcc tgcgcgtcc                                                    19


<210>  62
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  62
ggacgcgcag gcugccggu                                                    19


<210>  63
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  63
cgatgggcac ccactgctc                                                    19


<210>  64
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  64
gagcaguggg ugcccaucg                                                    19


<210>  65
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  65
ccttcacgtg gacgcgcag                                                    19


<210>  66
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  66
cugcgcgucc acgugaagg                                                    19


<210>  67
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  67
cgtgaaggtg gaagccttc                                                    19


<210>  68
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  68
gaaggcuucc accuucacg                                                    19


<210>  69
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  69
ctccttggtc aggcgccgg                                                    19


<210>  70
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  70
ccggcgccug accaaggag                                                    19


<210>  71
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  71
tggtcaggcg ccggttccg                                                    19


<210>  72
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  72
cggaaccggc gccugacca                                                    19


<210>  73
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  73
tagaggtcgc cttctcctc                                                    19


<210>  74
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  74
gaggagaagg cgaccucua                                                    19


<210>  75
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  75
cgacgctcgg gtcgcggtg                                                    19


<210>  76
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  76
caccgcgacc cgagcgucg                                                    19


<210>  77
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  77
atgctgtcgc cgcgcgggg                                                    19


<210>  78
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  78
ccccgcgcgg cgacagcau                                                    19


<210>  79
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  79
ctcaccctca ccggagcca                                                    19


<210>  80
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  80
uggcuccggu gagggugag                                                    19


<210>  81
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  81
ccgcaaactt tactcctta                                                    19


<210>  82
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  82
uaaggaguaa aguuugcgg                                                    19


<210>  83
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  83
ctcctaagat tggcttcac                                                    19


<210>  84
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  84
gugaagccaa ucuuaggag                                                    19


<210>  85
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  85
ccggagccac tcctaagat                                                    19


<210>  86
<211>  718
<212>  PRT
<213>  Homo sapiens

<400>  86

Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys Asp Lys Gly 
1               5                   10                  15      


Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser Val Ala Ala Val Arg 
            20                  25                  30          


Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala Ile Arg Ile 
        35                  40                  45              


Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser His Gly Cys 
    50                  55                  60                  


Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu Glu Lys Val 
65                  70                  75                  80  


Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro Thr Ala Val 
                85                  90                  95      


Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu Pro Met Ala 
            100                 105                 110         


Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser Tyr Asn Gly 
        115                 120                 125             


His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg Thr Cys Thr 
    130                 135                 140                 


Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe Ser Phe Gly 
145                 150                 155                 160 


Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly Arg Ser Pro 
                165                 170                 175     


Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu His Glu Lys 
            180                 185                 190         


Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu Ala Pro Ile 
        195                 200                 205             


Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val Glu Tyr Glu 
    210                 215                 220                 


Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly Arg Pro Phe 
225                 230                 235                 240 


Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro His Arg Asp 
                245                 250                 255     


Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr Leu Thr Arg 
            260                 265                 270         


Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu Gln Leu His 
        275                 280                 285             


Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe Gly Ser Lys 
    290                 295                 300                 


Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala Ile Glu Val Leu Ala 
305                 310                 315                 320 


Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val Pro Arg Ser 
                325                 330                 335     


Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala His Lys Ile 
            340                 345                 350         


Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg Lys Asn Asn 
        355                 360                 365             


Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro Thr Leu Gly 
    370                 375                 380                 


Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu Thr Glu Pro 
385                 390                 395                 400 


His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr Ser Leu Met 
                405                 410                 415     


Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser Pro Gly Phe Ser Trp 
            420                 425                 430         


Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys Asn Asp Ala 
        435                 440                 445             


Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro His Cys Thr 
    450                 455                 460                 


Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala Ala Asp Gly 
465                 470                 475                 480 


Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro Leu Pro Thr Leu Ser 
                485                 490                 495     


Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser Thr Gly Val 
            500                 505                 510         


Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro Ser Phe Leu 
        515                 520                 525             


Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu Asp Glu Gln 
    530                 535                 540                 


His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu Ser Asp Asp 
545                 550                 555                 560 


Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp Glu Tyr Trp 
                565                 570                 575     


Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly Gly Val Ala 
            580                 585                 590         


Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala Arg Arg Glu 
        595                 600                 605             


Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn His Pro Thr 
    610                 615                 620                 


Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn Lys Pro Gln 
625                 630                 635                 640 


His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys Glu Ala Lys 
                645                 650                 655     


Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala Ala Asn Glu 
            660                 665                 670         


Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln Ile Pro Ser 
        675                 680                 685             


His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr Val Ser Pro 
    690                 695                 700                 


Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp Val 
705                 710                 715             


<210>  87
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  87
ttctctaccc tacgtctca                                                    19


<210>  88
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  88
ugagacguag gguagagaa                                                    19


<210>  89
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  89
tacgtctcat tctccgcaa                                                    19


<210>  90
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  90
uugcggagaa ugagacgua                                                    19


<210>  91
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  91
gctaggcctc cagcccttc                                                    19


<210>  92
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  92
gaagggcugg aggccuagc                                                    19


<210>  93
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  93
acaggtggcg ccgcaactt                                                    19


<210>  94
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  94
aaguugcggc gccaccugu                                                    19


<210>  95
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  95
agccggaggc gcgagagtc                                                    19


<210>  96
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  96
gacucucgcg ccuccggcu                                                    19


<210>  97
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  97

Met Ala Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys Asp 
1               5                   10                  15      


Lys Gly Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser Val Ala Ala 
            20                  25                  30          


Val Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala Ile 
        35                  40                  45              


Arg Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser His 
    50                  55                  60                  


Gly Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu Glu 
65                  70                  75                  80  


Lys Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro Thr 
                85                  90                  95      


Ala Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu Pro 
            100                 105                 110         


Met Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser Tyr 
        115                 120                 125             


Asn Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg Thr 
    130                 135                 140                 


Cys Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe Ser 
145                 150                 155                 160 


Phe Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly Arg 
                165                 170                 175     


Ser Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu His 
            180                 185                 190         


Glu Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu Ala 
        195                 200                 205             


Pro Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val Glu 
    210                 215                 220                 


Tyr Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly Arg 
225                 230                 235                 240 


Pro Phe Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro His 
                245                 250                 255     


Arg Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr Leu 
            260                 265                 270         


Thr Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu Gln 
        275                 280                 285             


Leu His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe Gly 
    290                 295                 300                 


Ser Lys Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala Ile Glu Val 
305                 310                 315                 320 


Leu Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val Pro 
                325                 330                 335     


Arg Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala His 
            340                 345                 350         


Lys Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg Lys 
        355                 360                 365             


Asn Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro Thr 
    370                 375                 380                 


Leu Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu Thr 
385                 390                 395                 400 


Glu Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr Ser 
                405                 410                 415     


Leu Met Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser Pro Gly Phe 
            420                 425                 430         


Ser Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys Asn 
        435                 440                 445             


Asp Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro His 
    450                 455                 460                 


Cys Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala Ala 
465                 470                 475                 480 


Asp Gly Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro Leu Pro Thr 
                485                 490                 495     


Leu Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser Thr 
            500                 505                 510         


Gly Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro Ser 
        515                 520                 525             


Phe Leu Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu Asp 
    530                 535                 540                 


Glu Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu Ser 
545                 550                 555                 560 


Asp Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp Glu 
                565                 570                 575     


Tyr Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly Gly 
            580                 585                 590         


Val Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala Arg 
        595                 600                 605             


Arg Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn His 
    610                 615                 620                 


Pro Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn Lys 
625                 630                 635                 640 


Pro Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys Glu 
                645                 650                 655     


Ala Lys Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala Ala 
            660                 665                 670         


Asn Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln Ile 
        675                 680                 685             


Pro Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr Val 
    690                 695                 700                 


Ser Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp Val 
705                 710                 715                 720 


<210>  98
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  98

Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
1               5                   10                  15      


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
            20                  25                  30          


Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 
        35                  40                  45              


Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 
    50                  55                  60                  


Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 
65                  70                  75                  80  


Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 
                85                  90                  95      


Pro Gly Ser Glu 
            100 


<210>  99
<211>  2483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  99

Met Ala Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys Asp 
1               5                   10                  15      


Lys Gly Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser Val Ala Ala 
            20                  25                  30          


Val Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala Ile 
        35                  40                  45              


Arg Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser His 
    50                  55                  60                  


Gly Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu Glu 
65                  70                  75                  80  


Lys Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro Thr 
                85                  90                  95      


Ala Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu Pro 
            100                 105                 110         


Met Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser Tyr 
        115                 120                 125             


Asn Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg Thr 
    130                 135                 140                 


Cys Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe Ser 
145                 150                 155                 160 


Phe Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly Arg 
                165                 170                 175     


Ser Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu His 
            180                 185                 190         


Glu Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu Ala 
        195                 200                 205             


Pro Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val Glu 
    210                 215                 220                 


Tyr Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly Arg 
225                 230                 235                 240 


Pro Phe Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro His 
                245                 250                 255     


Arg Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr Leu 
            260                 265                 270         


Thr Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu Gln 
        275                 280                 285             


Leu His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe Gly 
    290                 295                 300                 


Ser Lys Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala Ile Glu Val 
305                 310                 315                 320 


Leu Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val Pro 
                325                 330                 335     


Arg Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala His 
            340                 345                 350         


Lys Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg Lys 
        355                 360                 365             


Asn Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro Thr 
    370                 375                 380                 


Leu Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu Thr 
385                 390                 395                 400 


Glu Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr Ser 
                405                 410                 415     


Leu Met Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser Pro Gly Phe 
            420                 425                 430         


Ser Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys Asn 
        435                 440                 445             


Asp Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro His 
    450                 455                 460                 


Cys Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala Ala 
465                 470                 475                 480 


Asp Gly Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro Leu Pro Thr 
                485                 490                 495     


Leu Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser Thr 
            500                 505                 510         


Gly Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro Ser 
        515                 520                 525             


Phe Leu Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu Asp 
    530                 535                 540                 


Glu Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu Ser 
545                 550                 555                 560 


Asp Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp Glu 
                565                 570                 575     


Tyr Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly Gly 
            580                 585                 590         


Val Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala Arg 
        595                 600                 605             


Arg Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn His 
    610                 615                 620                 


Pro Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn Lys 
625                 630                 635                 640 


Pro Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys Glu 
                645                 650                 655     


Ala Lys Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala Ala 
            660                 665                 670         


Asn Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln Ile 
        675                 680                 685             


Pro Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr Val 
    690                 695                 700                 


Ser Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp Val 
705                 710                 715                 720 


Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
                725                 730                 735     


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
            740                 745                 750         


Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 
        755                 760                 765             


Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 
    770                 775                 780                 


Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 
785                 790                 795                 800 


Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 
                805                 810                 815     


Pro Gly Ser Glu Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
            820                 825                 830         


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
        835                 840                 845             


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
    850                 855                 860                 


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
865                 870                 875                 880 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
                885                 890                 895     


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
            900                 905                 910         


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
        915                 920                 925             


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
    930                 935                 940                 


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
945                 950                 955                 960 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
                965                 970                 975     


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
            980                 985                 990         


Asp Leu Asn Pro Asp Asn Ser Asp  Val Asp Lys Leu Phe  Ile Gln Leu 
        995                 1000                 1005             


Val Gln  Thr Tyr Asn Gln Leu  Phe Glu Glu Asn Pro  Ile Asn Ala 
    1010                 1015                 1020             


Ser Gly  Val Asp Ala Lys Ala  Ile Leu Ser Ala Arg  Leu Ser Lys 
    1025                 1030                 1035             


Ser Arg  Arg Leu Glu Asn Leu  Ile Ala Gln Leu Pro  Gly Glu Lys 
    1040                 1045                 1050             


Lys Asn  Gly Leu Phe Gly Asn  Leu Ile Ala Leu Ser  Leu Gly Leu 
    1055                 1060                 1065             


Thr Pro  Asn Phe Lys Ser Asn  Phe Asp Leu Ala Glu  Asp Ala Lys 
    1070                 1075                 1080             


Leu Gln  Leu Ser Lys Asp Thr  Tyr Asp Asp Asp Leu  Asp Asn Leu 
    1085                 1090                 1095             


Leu Ala  Gln Ile Gly Asp Gln  Tyr Ala Asp Leu Phe  Leu Ala Ala 
    1100                 1105                 1110             


Lys Asn  Leu Ser Asp Ala Ile  Leu Leu Ser Asp Ile  Leu Arg Val 
    1115                 1120                 1125             


Asn Thr  Glu Ile Thr Lys Ala  Pro Leu Ser Ala Ser  Met Ile Lys 
    1130                 1135                 1140             


Arg Tyr  Asp Glu His His Gln  Asp Leu Thr Leu Leu  Lys Ala Leu 
    1145                 1150                 1155             


Val Arg  Gln Gln Leu Pro Glu  Lys Tyr Lys Glu Ile  Phe Phe Asp 
    1160                 1165                 1170             


Gln Ser  Lys Asn Gly Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser 
    1175                 1180                 1185             


Gln Glu  Glu Phe Tyr Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met 
    1190                 1195                 1200             


Asp Gly  Thr Glu Glu Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu 
    1205                 1210                 1215             


Leu Arg  Lys Gln Arg Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln 
    1220                 1225                 1230             


Ile His  Leu Gly Glu Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp 
    1235                 1240                 1245             


Phe Tyr  Pro Phe Leu Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile 
    1250                 1255                 1260             


Leu Thr  Phe Arg Ile Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly 
    1265                 1270                 1275             


Asn Ser  Arg Phe Ala Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile 
    1280                 1285                 1290             


Thr Pro  Trp Asn Phe Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala 
    1295                 1300                 1305             


Gln Ser  Phe Ile Glu Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro 
    1310                 1315                 1320             


Asn Glu  Lys Val Leu Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe 
    1325                 1330                 1335             


Thr Val  Tyr Asn Glu Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly 
    1340                 1345                 1350             


Met Arg  Lys Pro Ala Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile 
    1355                 1360                 1365             


Val Asp  Leu Leu Phe Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln 
    1370                 1375                 1380             


Leu Lys  Glu Asp Tyr Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val 
    1385                 1390                 1395             


Glu Ile  Ser Gly Val Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr 
    1400                 1405                 1410             


Tyr His  Asp Leu Leu Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp 
    1415                 1420                 1425             


Asn Glu  Glu Asn Glu Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu 
    1430                 1435                 1440             


Thr Leu  Phe Glu Asp Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr 
    1445                 1450                 1455             


Tyr Ala  His Leu Phe Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg 
    1460                 1465                 1470             


Arg Arg  Tyr Thr Gly Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn 
    1475                 1480                 1485             


Gly Ile  Arg Asp Lys Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu 
    1490                 1495                 1500             


Lys Ser  Asp Gly Phe Ala Asn  Arg Asn Phe Met Gln  Leu Ile His 
    1505                 1510                 1515             


Asp Asp  Ser Leu Thr Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val 
    1520                 1525                 1530             


Ser Gly  Gln Gly Asp Ser Leu  His Glu His Ile Ala  Asn Leu Ala 
    1535                 1540                 1545             


Gly Ser  Pro Ala Ile Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val 
    1550                 1555                 1560             


Val Asp  Glu Leu Val Lys Val  Met Gly Arg His Lys  Pro Glu Asn 
    1565                 1570                 1575             


Ile Val  Ile Glu Met Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly 
    1580                 1585                 1590             


Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile 
    1595                 1600                 1605             


Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His Pro  Val Glu Asn 
    1610                 1615                 1620             


Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn 
    1625                 1630                 1635             


Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu 
    1640                 1645                 1650             


Ser Asp  Tyr Asp Val Asp Ala  Ile Val Pro Gln Ser  Phe Leu Lys 
    1655                 1660                 1665             


Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn 
    1670                 1675                 1680             


Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu Val  Val Lys Lys 
    1685                 1690                 1695             


Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr 
    1700                 1705                 1710             


Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu 
    1715                 1720                 1725             


Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu 
    1730                 1735                 1740             


Thr Arg  Gln Ile Thr Lys His  Val Ala Gln Ile Leu  Asp Ser Arg 
    1745                 1750                 1755             


Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val 
    1760                 1765                 1770             


Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys 
    1775                 1780                 1785             


Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn Asn  Tyr His His 
    1790                 1795                 1800             


Ala His  Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile 
    1805                 1810                 1815             


Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr 
    1820                 1825                 1830             


Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu 
    1835                 1840                 1845             


Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met 
    1850                 1855                 1860             


Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg 
    1865                 1870                 1875             


Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val 
    1880                 1885                 1890             


Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser 
    1895                 1900                 1905             


Met Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1910                 1915                 1920             


Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys 
    1925                 1930                 1935             


Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly 
    1940                 1945                 1950             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Val Ala Lys 
    1955                 1960                 1965             


Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu 
    1970                 1975                 1980             


Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro 
    1985                 1990                 1995             


Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp 
    2000                 2005                 2010             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    2015                 2020                 2025             


Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly 
    2030                 2035                 2040             


Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu 
    2045                 2050                 2055             


Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu 
    2060                 2065                 2070             


Gln Lys  Gln Leu Phe Val Glu  Gln His Lys His Tyr  Leu Asp Glu 
    2075                 2080                 2085             


Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala 
    2090                 2095                 2100             


Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg 
    2105                 2110                 2115             


Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe 
    2120                 2125                 2130             


Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp 
    2135                 2140                 2145             


Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    2150                 2155                 2160             


Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    2165                 2170                 2175             


Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp Gly Gly  Pro Ser Ser 
    2180                 2185                 2190             


Gly Ala  Pro Pro Pro Ser Gly  Gly Ser Pro Ala Gly  Ser Pro Thr 
    2195                 2200                 2205             


Ser Thr  Glu Glu Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 
    2210                 2215                 2220             


Pro Gly  Thr Ser Thr Glu Pro  Ser Glu Gly Ser Ala  Pro Gly Ser 
    2225                 2230                 2235             


Pro Ala  Gly Ser Pro Thr Ser  Thr Glu Glu Gly Thr  Ser Thr Glu 
    2240                 2245                 2250             


Pro Ser  Glu Gly Ser Ala Pro  Gly Thr Ser Thr Glu  Pro Ser Glu 
    2255                 2260                 2265             


Gly Ser  Gly Pro Lys Lys Lys  Arg Lys Val Ala Gly  Ser Arg Asp 
    2270                 2275                 2280             


Ser Arg  Glu Gly Met Phe Leu  Pro Lys Pro Glu Ala  Gly Ser Ala 
    2285                 2290                 2295             


Ile Ser  Asp Val Phe Glu Gly  Arg Glu Val Cys Gln  Pro Lys Arg 
    2300                 2305                 2310             


Ile Arg  Pro Phe His Pro Pro  Gly Ser Pro Trp Ala  Asn Arg Pro 
    2315                 2320                 2325             


Leu Pro  Ala Ser Leu Ala Pro  Thr Pro Thr Gly Pro  Val His Glu 
    2330                 2335                 2340             


Pro Val  Gly Ser Leu Thr Pro  Ala Pro Val Pro Gln  Pro Leu Asp 
    2345                 2350                 2355             


Pro Ala  Pro Ala Val Thr Pro  Glu Ala Ser His Leu  Leu Glu Asp 
    2360                 2365                 2370             


Pro Asp  Glu Glu Thr Ser Gln  Ala Val Lys Ala Leu  Arg Glu Met 
    2375                 2380                 2385             


Ala Asp  Thr Val Ile Pro Gln  Lys Glu Glu Ala Ala  Ile Cys Gly 
    2390                 2395                 2400             


Gln Met  Asp Leu Ser His Pro  Pro Pro Arg Gly His  Leu Asp Glu 
    2405                 2410                 2415             


Leu Thr  Thr Thr Leu Glu Ser  Met Thr Glu Asp Leu  Asn Leu Asp 
    2420                 2425                 2430             


Ser Pro  Leu Thr Pro Glu Leu  Asn Glu Ile Leu Asp  Thr Phe Leu 
    2435                 2440                 2445             


Asn Asp  Glu Cys Leu Leu His  Ala Met His Ile Ser  Thr Gly Leu 
    2450                 2455                 2460             


Ser Ile  Phe Asp Thr Ser Leu  Phe Ala Ser Gly Ser  Gly Pro Lys 
    2465                 2470                 2475             


Lys Lys  Arg Lys Val 
    2480             


<210>  100
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  100

Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys 
1               5                   10                  15      


Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro 
            20                  25                  30          


Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val 
        35                  40                  45              


Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr 
    50                  55                  60                  


Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr 
65                  70                  75                  80  


Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro 
                85                  90                  95      


Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro 
            100                 105                 110         


Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu 
        115                 120                 125             


Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr 
    130                 135                 140                 


Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe 
145                 150                 155                 160 


Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala 
                165                 170                 175     


Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu 
            180                 185                 190         


Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu 
        195                 200                 205             


Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg 
    210                 215                 220                 


Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn 
225                 230                 235                 240 


Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp 
                245                 250                 255     


Phe Ser Ala Leu Leu 
            260     


<210>  101
<211>  2750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  101

Met Ala Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys Asp 
1               5                   10                  15      


Lys Gly Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser Val Ala Ala 
            20                  25                  30          


Val Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala Ile 
        35                  40                  45              


Arg Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser His 
    50                  55                  60                  


Gly Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu Glu 
65                  70                  75                  80  


Lys Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro Thr 
                85                  90                  95      


Ala Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu Pro 
            100                 105                 110         


Met Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser Tyr 
        115                 120                 125             


Asn Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg Thr 
    130                 135                 140                 


Cys Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe Ser 
145                 150                 155                 160 


Phe Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly Arg 
                165                 170                 175     


Ser Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu His 
            180                 185                 190         


Glu Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu Ala 
        195                 200                 205             


Pro Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val Glu 
    210                 215                 220                 


Tyr Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly Arg 
225                 230                 235                 240 


Pro Phe Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro His 
                245                 250                 255     


Arg Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr Leu 
            260                 265                 270         


Thr Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu Gln 
        275                 280                 285             


Leu His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe Gly 
    290                 295                 300                 


Ser Lys Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala Ile Glu Val 
305                 310                 315                 320 


Leu Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val Pro 
                325                 330                 335     


Arg Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala His 
            340                 345                 350         


Lys Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg Lys 
        355                 360                 365             


Asn Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro Thr 
    370                 375                 380                 


Leu Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu Thr 
385                 390                 395                 400 


Glu Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr Ser 
                405                 410                 415     


Leu Met Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser Pro Gly Phe 
            420                 425                 430         


Ser Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys Asn 
        435                 440                 445             


Asp Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro His 
    450                 455                 460                 


Cys Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala Ala 
465                 470                 475                 480 


Asp Gly Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro Leu Pro Thr 
                485                 490                 495     


Leu Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser Thr 
            500                 505                 510         


Gly Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro Ser 
        515                 520                 525             


Phe Leu Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu Asp 
    530                 535                 540                 


Glu Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu Ser 
545                 550                 555                 560 


Asp Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp Glu 
                565                 570                 575     


Tyr Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly Gly 
            580                 585                 590         


Val Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala Arg 
        595                 600                 605             


Arg Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn His 
    610                 615                 620                 


Pro Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn Lys 
625                 630                 635                 640 


Pro Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys Glu 
                645                 650                 655     


Ala Lys Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala Ala 
            660                 665                 670         


Asn Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln Ile 
        675                 680                 685             


Pro Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr Val 
    690                 695                 700                 


Ser Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp Val 
705                 710                 715                 720 


Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
                725                 730                 735     


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
            740                 745                 750         


Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 
        755                 760                 765             


Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 
    770                 775                 780                 


Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 
785                 790                 795                 800 


Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 
                805                 810                 815     


Pro Gly Ser Glu Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
            820                 825                 830         


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
        835                 840                 845             


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
    850                 855                 860                 


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
865                 870                 875                 880 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
                885                 890                 895     


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
            900                 905                 910         


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
        915                 920                 925             


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
    930                 935                 940                 


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
945                 950                 955                 960 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
                965                 970                 975     


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
            980                 985                 990         


Asp Leu Asn Pro Asp Asn Ser Asp  Val Asp Lys Leu Phe  Ile Gln Leu 
        995                 1000                 1005             


Val Gln  Thr Tyr Asn Gln Leu  Phe Glu Glu Asn Pro  Ile Asn Ala 
    1010                 1015                 1020             


Ser Gly  Val Asp Ala Lys Ala  Ile Leu Ser Ala Arg  Leu Ser Lys 
    1025                 1030                 1035             


Ser Arg  Arg Leu Glu Asn Leu  Ile Ala Gln Leu Pro  Gly Glu Lys 
    1040                 1045                 1050             


Lys Asn  Gly Leu Phe Gly Asn  Leu Ile Ala Leu Ser  Leu Gly Leu 
    1055                 1060                 1065             


Thr Pro  Asn Phe Lys Ser Asn  Phe Asp Leu Ala Glu  Asp Ala Lys 
    1070                 1075                 1080             


Leu Gln  Leu Ser Lys Asp Thr  Tyr Asp Asp Asp Leu  Asp Asn Leu 
    1085                 1090                 1095             


Leu Ala  Gln Ile Gly Asp Gln  Tyr Ala Asp Leu Phe  Leu Ala Ala 
    1100                 1105                 1110             


Lys Asn  Leu Ser Asp Ala Ile  Leu Leu Ser Asp Ile  Leu Arg Val 
    1115                 1120                 1125             


Asn Thr  Glu Ile Thr Lys Ala  Pro Leu Ser Ala Ser  Met Ile Lys 
    1130                 1135                 1140             


Arg Tyr  Asp Glu His His Gln  Asp Leu Thr Leu Leu  Lys Ala Leu 
    1145                 1150                 1155             


Val Arg  Gln Gln Leu Pro Glu  Lys Tyr Lys Glu Ile  Phe Phe Asp 
    1160                 1165                 1170             


Gln Ser  Lys Asn Gly Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser 
    1175                 1180                 1185             


Gln Glu  Glu Phe Tyr Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met 
    1190                 1195                 1200             


Asp Gly  Thr Glu Glu Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu 
    1205                 1210                 1215             


Leu Arg  Lys Gln Arg Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln 
    1220                 1225                 1230             


Ile His  Leu Gly Glu Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp 
    1235                 1240                 1245             


Phe Tyr  Pro Phe Leu Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile 
    1250                 1255                 1260             


Leu Thr  Phe Arg Ile Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly 
    1265                 1270                 1275             


Asn Ser  Arg Phe Ala Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile 
    1280                 1285                 1290             


Thr Pro  Trp Asn Phe Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala 
    1295                 1300                 1305             


Gln Ser  Phe Ile Glu Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro 
    1310                 1315                 1320             


Asn Glu  Lys Val Leu Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe 
    1325                 1330                 1335             


Thr Val  Tyr Asn Glu Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly 
    1340                 1345                 1350             


Met Arg  Lys Pro Ala Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile 
    1355                 1360                 1365             


Val Asp  Leu Leu Phe Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln 
    1370                 1375                 1380             


Leu Lys  Glu Asp Tyr Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val 
    1385                 1390                 1395             


Glu Ile  Ser Gly Val Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr 
    1400                 1405                 1410             


Tyr His  Asp Leu Leu Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp 
    1415                 1420                 1425             


Asn Glu  Glu Asn Glu Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu 
    1430                 1435                 1440             


Thr Leu  Phe Glu Asp Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr 
    1445                 1450                 1455             


Tyr Ala  His Leu Phe Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg 
    1460                 1465                 1470             


Arg Arg  Tyr Thr Gly Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn 
    1475                 1480                 1485             


Gly Ile  Arg Asp Lys Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu 
    1490                 1495                 1500             


Lys Ser  Asp Gly Phe Ala Asn  Arg Asn Phe Met Gln  Leu Ile His 
    1505                 1510                 1515             


Asp Asp  Ser Leu Thr Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val 
    1520                 1525                 1530             


Ser Gly  Gln Gly Asp Ser Leu  His Glu His Ile Ala  Asn Leu Ala 
    1535                 1540                 1545             


Gly Ser  Pro Ala Ile Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val 
    1550                 1555                 1560             


Val Asp  Glu Leu Val Lys Val  Met Gly Arg His Lys  Pro Glu Asn 
    1565                 1570                 1575             


Ile Val  Ile Glu Met Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly 
    1580                 1585                 1590             


Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile 
    1595                 1600                 1605             


Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His Pro  Val Glu Asn 
    1610                 1615                 1620             


Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn 
    1625                 1630                 1635             


Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu 
    1640                 1645                 1650             


Ser Asp  Tyr Asp Val Asp Ala  Ile Val Pro Gln Ser  Phe Leu Lys 
    1655                 1660                 1665             


Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn 
    1670                 1675                 1680             


Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu Val  Val Lys Lys 
    1685                 1690                 1695             


Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr 
    1700                 1705                 1710             


Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu 
    1715                 1720                 1725             


Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu 
    1730                 1735                 1740             


Thr Arg  Gln Ile Thr Lys His  Val Ala Gln Ile Leu  Asp Ser Arg 
    1745                 1750                 1755             


Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val 
    1760                 1765                 1770             


Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys 
    1775                 1780                 1785             


Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn Asn  Tyr His His 
    1790                 1795                 1800             


Ala His  Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile 
    1805                 1810                 1815             


Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr 
    1820                 1825                 1830             


Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu 
    1835                 1840                 1845             


Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met 
    1850                 1855                 1860             


Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg 
    1865                 1870                 1875             


Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val 
    1880                 1885                 1890             


Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser 
    1895                 1900                 1905             


Met Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1910                 1915                 1920             


Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys 
    1925                 1930                 1935             


Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly 
    1940                 1945                 1950             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Val Ala Lys 
    1955                 1960                 1965             


Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu 
    1970                 1975                 1980             


Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro 
    1985                 1990                 1995             


Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp 
    2000                 2005                 2010             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    2015                 2020                 2025             


Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly 
    2030                 2035                 2040             


Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu 
    2045                 2050                 2055             


Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu 
    2060                 2065                 2070             


Gln Lys  Gln Leu Phe Val Glu  Gln His Lys His Tyr  Leu Asp Glu 
    2075                 2080                 2085             


Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala 
    2090                 2095                 2100             


Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg 
    2105                 2110                 2115             


Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe 
    2120                 2125                 2130             


Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp 
    2135                 2140                 2145             


Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    2150                 2155                 2160             


Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    2165                 2170                 2175             


Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp Gly Gly  Pro Ser Ser 
    2180                 2185                 2190             


Gly Ala  Pro Pro Pro Ser Gly  Gly Ser Pro Ala Gly  Ser Pro Thr 
    2195                 2200                 2205             


Ser Thr  Glu Glu Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Gly 
    2210                 2215                 2220             


Pro Gly  Thr Ser Thr Glu Pro  Ser Glu Gly Ser Ala  Pro Gly Ser 
    2225                 2230                 2235             


Pro Ala  Gly Ser Pro Thr Ser  Thr Glu Glu Gly Thr  Ser Thr Glu 
    2240                 2245                 2250             


Pro Ser  Glu Gly Ser Ala Pro  Gly Thr Ser Thr Glu  Pro Ser Glu 
    2255                 2260                 2265             


Gly Ser  Gly Pro Lys Lys Lys  Arg Lys Val Ala Gly  Ser Ser Gln 
    2270                 2275                 2280             


Tyr Leu  Pro Asp Thr Asp Asp  Arg His Arg Ile Glu  Glu Lys Arg 
    2285                 2290                 2295             


Lys Arg  Thr Tyr Glu Thr Phe  Lys Ser Ile Met Lys  Lys Ser Pro 
    2300                 2305                 2310             


Phe Ser  Gly Pro Thr Asp Pro  Arg Pro Pro Pro Arg  Arg Ile Ala 
    2315                 2320                 2325             


Val Pro  Ser Arg Ser Ser Ala  Ser Val Pro Lys Pro  Ala Pro Gln 
    2330                 2335                 2340             


Pro Tyr  Pro Phe Thr Ser Ser  Leu Ser Thr Ile Asn  Tyr Asp Glu 
    2345                 2350                 2355             


Phe Pro  Thr Met Val Phe Pro  Ser Gly Gln Ile Ser  Gln Ala Ser 
    2360                 2365                 2370             


Ala Leu  Ala Pro Ala Pro Pro  Gln Val Leu Pro Gln  Ala Pro Ala 
    2375                 2380                 2385             


Pro Ala  Pro Ala Pro Ala Met  Val Ser Ala Leu Ala  Gln Ala Pro 
    2390                 2395                 2400             


Ala Pro  Val Pro Val Leu Ala  Pro Gly Pro Pro Gln  Ala Val Ala 
    2405                 2410                 2415             


Pro Pro  Ala Pro Lys Pro Thr  Gln Ala Gly Glu Gly  Thr Leu Ser 
    2420                 2425                 2430             


Glu Ala  Leu Leu Gln Leu Gln  Phe Asp Asp Glu Asp  Leu Gly Ala 
    2435                 2440                 2445             


Leu Leu  Gly Asn Ser Thr Asp  Pro Ala Val Phe Thr  Asp Leu Ala 
    2450                 2455                 2460             


Ser Val  Asp Asn Ser Glu Phe  Gln Gln Leu Leu Asn  Gln Gly Ile 
    2465                 2470                 2475             


Pro Val  Ala Pro His Thr Thr  Glu Pro Met Leu Met  Glu Tyr Pro 
    2480                 2485                 2490             


Glu Ala  Ile Thr Arg Leu Val  Thr Gly Ala Gln Arg  Pro Pro Asp 
    2495                 2500                 2505             


Pro Ala  Pro Ala Pro Leu Gly  Ala Pro Gly Leu Pro  Asn Gly Leu 
    2510                 2515                 2520             


Leu Ser  Gly Asp Glu Asp Phe  Ser Ser Ile Ala Asp  Met Asp Phe 
    2525                 2530                 2535             


Ser Ala  Leu Leu Gly Ser Gly  Ser Gly Ser Arg Asp  Ser Arg Glu 
    2540                 2545                 2550             


Gly Met  Phe Leu Pro Lys Pro  Glu Ala Gly Ser Ala  Ile Ser Asp 
    2555                 2560                 2565             


Val Phe  Glu Gly Arg Glu Val  Cys Gln Pro Lys Arg  Ile Arg Pro 
    2570                 2575                 2580             


Phe His  Pro Pro Gly Ser Pro  Trp Ala Asn Arg Pro  Leu Pro Ala 
    2585                 2590                 2595             


Ser Leu  Ala Pro Thr Pro Thr  Gly Pro Val His Glu  Pro Val Gly 
    2600                 2605                 2610             


Ser Leu  Thr Pro Ala Pro Val  Pro Gln Pro Leu Asp  Pro Ala Pro 
    2615                 2620                 2625             


Ala Val  Thr Pro Glu Ala Ser  His Leu Leu Glu Asp  Pro Asp Glu 
    2630                 2635                 2640             


Glu Thr  Ser Gln Ala Val Lys  Ala Leu Arg Glu Met  Ala Asp Thr 
    2645                 2650                 2655             


Val Ile  Pro Gln Lys Glu Glu  Ala Ala Ile Cys Gly  Gln Met Asp 
    2660                 2665                 2670             


Leu Ser  His Pro Pro Pro Arg  Gly His Leu Asp Glu  Leu Thr Thr 
    2675                 2680                 2685             


Thr Leu  Glu Ser Met Thr Glu  Asp Leu Asn Leu Asp  Ser Pro Leu 
    2690                 2695                 2700             


Thr Pro  Glu Leu Asn Glu Ile  Leu Asp Thr Phe Leu  Asn Asp Glu 
    2705                 2710                 2715             


Cys Leu  Leu His Ala Met His  Ile Ser Thr Gly Leu  Ser Ile Phe 
    2720                 2725                 2730             


Asp Thr  Ser Leu Phe Ala Ser  Gly Ser Gly Pro Lys  Lys Lys Arg 
    2735                 2740                 2745             


Lys Val  
    2750 


<210>  102
<211>  2216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  102

Met Ala Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys Asp 
1               5                   10                  15      


Lys Gly Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser Val Ala Ala 
            20                  25                  30          


Val Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala Ile 
        35                  40                  45              


Arg Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser His 
    50                  55                  60                  


Gly Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu Glu 
65                  70                  75                  80  


Lys Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro Thr 
                85                  90                  95      


Ala Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu Pro 
            100                 105                 110         


Met Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser Tyr 
        115                 120                 125             


Asn Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg Thr 
    130                 135                 140                 


Cys Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe Ser 
145                 150                 155                 160 


Phe Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly Arg 
                165                 170                 175     


Ser Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu His 
            180                 185                 190         


Glu Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu Ala 
        195                 200                 205             


Pro Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val Glu 
    210                 215                 220                 


Tyr Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly Arg 
225                 230                 235                 240 


Pro Phe Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro His 
                245                 250                 255     


Arg Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr Leu 
            260                 265                 270         


Thr Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu Gln 
        275                 280                 285             


Leu His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe Gly 
    290                 295                 300                 


Ser Lys Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala Ile Glu Val 
305                 310                 315                 320 


Leu Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val Pro 
                325                 330                 335     


Arg Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala His 
            340                 345                 350         


Lys Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg Lys 
        355                 360                 365             


Asn Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro Thr 
    370                 375                 380                 


Leu Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu Thr 
385                 390                 395                 400 


Glu Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr Ser 
                405                 410                 415     


Leu Met Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser Pro Gly Phe 
            420                 425                 430         


Ser Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys Asn 
        435                 440                 445             


Asp Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro His 
    450                 455                 460                 


Cys Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala Ala 
465                 470                 475                 480 


Asp Gly Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro Leu Pro Thr 
                485                 490                 495     


Leu Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser Thr 
            500                 505                 510         


Gly Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro Ser 
        515                 520                 525             


Phe Leu Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu Asp 
    530                 535                 540                 


Glu Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu Ser 
545                 550                 555                 560 


Asp Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp Glu 
                565                 570                 575     


Tyr Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly Gly 
            580                 585                 590         


Val Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala Arg 
        595                 600                 605             


Arg Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn His 
    610                 615                 620                 


Pro Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn Lys 
625                 630                 635                 640 


Pro Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys Glu 
                645                 650                 655     


Ala Lys Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala Ala 
            660                 665                 670         


Asn Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln Ile 
        675                 680                 685             


Pro Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr Val 
    690                 695                 700                 


Ser Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp Val 
705                 710                 715                 720 


Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 
                725                 730                 735     


Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 
            740                 745                 750         


Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 
        755                 760                 765             


Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 
    770                 775                 780                 


Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 
785                 790                 795                 800 


Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 
                805                 810                 815     


Pro Gly Ser Glu Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly 
            820                 825                 830         


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
        835                 840                 845             


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
    850                 855                 860                 


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
865                 870                 875                 880 


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
                885                 890                 895     


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
            900                 905                 910         


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
        915                 920                 925             


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
    930                 935                 940                 


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
945                 950                 955                 960 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
                965                 970                 975     


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
            980                 985                 990         


Asp Leu Asn Pro Asp Asn Ser Asp  Val Asp Lys Leu Phe  Ile Gln Leu 
        995                 1000                 1005             


Val Gln  Thr Tyr Asn Gln Leu  Phe Glu Glu Asn Pro  Ile Asn Ala 
    1010                 1015                 1020             


Ser Gly  Val Asp Ala Lys Ala  Ile Leu Ser Ala Arg  Leu Ser Lys 
    1025                 1030                 1035             


Ser Arg  Arg Leu Glu Asn Leu  Ile Ala Gln Leu Pro  Gly Glu Lys 
    1040                 1045                 1050             


Lys Asn  Gly Leu Phe Gly Asn  Leu Ile Ala Leu Ser  Leu Gly Leu 
    1055                 1060                 1065             


Thr Pro  Asn Phe Lys Ser Asn  Phe Asp Leu Ala Glu  Asp Ala Lys 
    1070                 1075                 1080             


Leu Gln  Leu Ser Lys Asp Thr  Tyr Asp Asp Asp Leu  Asp Asn Leu 
    1085                 1090                 1095             


Leu Ala  Gln Ile Gly Asp Gln  Tyr Ala Asp Leu Phe  Leu Ala Ala 
    1100                 1105                 1110             


Lys Asn  Leu Ser Asp Ala Ile  Leu Leu Ser Asp Ile  Leu Arg Val 
    1115                 1120                 1125             


Asn Thr  Glu Ile Thr Lys Ala  Pro Leu Ser Ala Ser  Met Ile Lys 
    1130                 1135                 1140             


Arg Tyr  Asp Glu His His Gln  Asp Leu Thr Leu Leu  Lys Ala Leu 
    1145                 1150                 1155             


Val Arg  Gln Gln Leu Pro Glu  Lys Tyr Lys Glu Ile  Phe Phe Asp 
    1160                 1165                 1170             


Gln Ser  Lys Asn Gly Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser 
    1175                 1180                 1185             


Gln Glu  Glu Phe Tyr Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met 
    1190                 1195                 1200             


Asp Gly  Thr Glu Glu Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu 
    1205                 1210                 1215             


Leu Arg  Lys Gln Arg Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln 
    1220                 1225                 1230             


Ile His  Leu Gly Glu Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp 
    1235                 1240                 1245             


Phe Tyr  Pro Phe Leu Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile 
    1250                 1255                 1260             


Leu Thr  Phe Arg Ile Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly 
    1265                 1270                 1275             


Asn Ser  Arg Phe Ala Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile 
    1280                 1285                 1290             


Thr Pro  Trp Asn Phe Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala 
    1295                 1300                 1305             


Gln Ser  Phe Ile Glu Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro 
    1310                 1315                 1320             


Asn Glu  Lys Val Leu Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe 
    1325                 1330                 1335             


Thr Val  Tyr Asn Glu Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly 
    1340                 1345                 1350             


Met Arg  Lys Pro Ala Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile 
    1355                 1360                 1365             


Val Asp  Leu Leu Phe Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln 
    1370                 1375                 1380             


Leu Lys  Glu Asp Tyr Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val 
    1385                 1390                 1395             


Glu Ile  Ser Gly Val Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr 
    1400                 1405                 1410             


Tyr His  Asp Leu Leu Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp 
    1415                 1420                 1425             


Asn Glu  Glu Asn Glu Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu 
    1430                 1435                 1440             


Thr Leu  Phe Glu Asp Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr 
    1445                 1450                 1455             


Tyr Ala  His Leu Phe Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg 
    1460                 1465                 1470             


Arg Arg  Tyr Thr Gly Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn 
    1475                 1480                 1485             


Gly Ile  Arg Asp Lys Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu 
    1490                 1495                 1500             


Lys Ser  Asp Gly Phe Ala Asn  Arg Asn Phe Met Gln  Leu Ile His 
    1505                 1510                 1515             


Asp Asp  Ser Leu Thr Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val 
    1520                 1525                 1530             


Ser Gly  Gln Gly Asp Ser Leu  His Glu His Ile Ala  Asn Leu Ala 
    1535                 1540                 1545             


Gly Ser  Pro Ala Ile Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val 
    1550                 1555                 1560             


Val Asp  Glu Leu Val Lys Val  Met Gly Arg His Lys  Pro Glu Asn 
    1565                 1570                 1575             


Ile Val  Ile Glu Met Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly 
    1580                 1585                 1590             


Gln Lys  Asn Ser Arg Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile 
    1595                 1600                 1605             


Lys Glu  Leu Gly Ser Gln Ile  Leu Lys Glu His Pro  Val Glu Asn 
    1610                 1615                 1620             


Thr Gln  Leu Gln Asn Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn 
    1625                 1630                 1635             


Gly Arg  Asp Met Tyr Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu 
    1640                 1645                 1650             


Ser Asp  Tyr Asp Val Asp Ala  Ile Val Pro Gln Ser  Phe Leu Lys 
    1655                 1660                 1665             


Asp Asp  Ser Ile Asp Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn 
    1670                 1675                 1680             


Arg Gly  Lys Ser Asp Asn Val  Pro Ser Glu Glu Val  Val Lys Lys 
    1685                 1690                 1695             


Met Lys  Asn Tyr Trp Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr 
    1700                 1705                 1710             


Gln Arg  Lys Phe Asp Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu 
    1715                 1720                 1725             


Ser Glu  Leu Asp Lys Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu 
    1730                 1735                 1740             


Thr Arg  Gln Ile Thr Lys His  Val Ala Gln Ile Leu  Asp Ser Arg 
    1745                 1750                 1755             


Met Asn  Thr Lys Tyr Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val 
    1760                 1765                 1770             


Lys Val  Ile Thr Leu Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys 
    1775                 1780                 1785             


Asp Phe  Gln Phe Tyr Lys Val  Arg Glu Ile Asn Asn  Tyr His His 
    1790                 1795                 1800             


Ala His  Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile 
    1805                 1810                 1815             


Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr 
    1820                 1825                 1830             


Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu 
    1835                 1840                 1845             


Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met 
    1850                 1855                 1860             


Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg 
    1865                 1870                 1875             


Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val 
    1880                 1885                 1890             


Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser 
    1895                 1900                 1905             


Met Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1910                 1915                 1920             


Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys 
    1925                 1930                 1935             


Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly 
    1940                 1945                 1950             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Val Ala Lys 
    1955                 1960                 1965             


Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu 
    1970                 1975                 1980             


Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro 
    1985                 1990                 1995             


Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp 
    2000                 2005                 2010             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    2015                 2020                 2025             


Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly 
    2030                 2035                 2040             


Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu 
    2045                 2050                 2055             


Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu 
    2060                 2065                 2070             


Gln Lys  Gln Leu Phe Val Glu  Gln His Lys His Tyr  Leu Asp Glu 
    2075                 2080                 2085             


Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala 
    2090                 2095                 2100             


Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg 
    2105                 2110                 2115             


Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe 
    2120                 2125                 2130             


Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp 
    2135                 2140                 2145             


Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    2150                 2155                 2160             


Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    2165                 2170                 2175             


Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp Gly Gly  Gly Gly Ser 
    2180                 2185                 2190             


Pro Lys  Lys Lys Arg Lys Val  Asp Pro Lys Lys Lys  Arg Lys Val 
    2195                 2200                 2205             


Asp Pro  Lys Lys Lys Arg Lys  Val 
    2210                 2215     


<210>  103
<211>  2116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  103

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Gly  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  Asp Pro Lys 
    1370                 1375                 1380             


Lys Lys  Arg Lys Val Asp Pro  Lys Lys Lys Arg Lys  Val Gly Ser 
    1385                 1390                 1395             


Leu Pro  Thr Cys Ser Cys Leu  Asp Arg Val Ile Gln  Lys Asp Lys 
    1400                 1405                 1410             


Gly Pro  Tyr Tyr Thr His Leu  Gly Ala Gly Pro Ser  Val Ala Ala 
    1415                 1420                 1425             


Val Arg  Glu Ile Met Glu Asn  Arg Tyr Gly Gln Lys  Gly Asn Ala 
    1430                 1435                 1440             


Ile Arg  Ile Glu Ile Val Val  Tyr Thr Gly Lys Glu  Gly Lys Ser 
    1445                 1450                 1455             


Ser His  Gly Cys Pro Ile Ala  Lys Trp Val Leu Arg  Arg Ser Ser 
    1460                 1465                 1470             


Asp Glu  Glu Lys Val Leu Cys  Leu Val Arg Gln Arg  Thr Gly His 
    1475                 1480                 1485             


His Cys  Pro Thr Ala Val Met  Val Val Leu Ile Met  Val Trp Asp 
    1490                 1495                 1500             


Gly Ile  Pro Leu Pro Met Ala  Asp Arg Leu Tyr Thr  Glu Leu Thr 
    1505                 1510                 1515             


Glu Asn  Leu Lys Ser Tyr Asn  Gly His Pro Thr Asp  Arg Arg Cys 
    1520                 1525                 1530             


Thr Leu  Asn Glu Asn Arg Thr  Cys Thr Cys Gln Gly  Ile Asp Pro 
    1535                 1540                 1545             


Glu Thr  Cys Gly Ala Ser Phe  Ser Phe Gly Cys Ser  Trp Ser Met 
    1550                 1555                 1560             


Tyr Phe  Asn Gly Cys Lys Phe  Gly Arg Ser Pro Ser  Pro Arg Arg 
    1565                 1570                 1575             


Phe Arg  Ile Asp Pro Ser Ser  Pro Leu His Glu Lys  Asn Leu Glu 
    1580                 1585                 1590             


Asp Asn  Leu Gln Ser Leu Ala  Thr Arg Leu Ala Pro  Ile Tyr Lys 
    1595                 1600                 1605             


Gln Tyr  Ala Pro Val Ala Tyr  Gln Asn Gln Val Glu  Tyr Glu Asn 
    1610                 1615                 1620             


Val Ala  Arg Glu Cys Arg Leu  Gly Ser Lys Glu Gly  Arg Pro Phe 
    1625                 1630                 1635             


Ser Gly  Val Thr Ala Cys Leu  Asp Phe Cys Ala His  Pro His Arg 
    1640                 1645                 1650             


Asp Ile  His Asn Met Asn Asn  Gly Ser Thr Val Val  Cys Thr Leu 
    1655                 1660                 1665             


Thr Arg  Glu Asp Asn Arg Ser  Leu Gly Val Ile Pro  Gln Asp Glu 
    1670                 1675                 1680             


Gln Leu  His Val Leu Pro Leu  Tyr Lys Leu Ser Asp  Thr Asp Glu 
    1685                 1690                 1695             


Phe Gly  Ser Lys Glu Gly Met  Glu Ala Lys Ile Lys  Ser Gly Ala 
    1700                 1705                 1710             


Ile Glu  Val Leu Ala Pro Arg  Arg Lys Lys Arg Thr  Cys Phe Thr 
    1715                 1720                 1725             


Gln Pro  Val Pro Arg Ser Gly  Lys Lys Arg Ala Ala  Met Met Thr 
    1730                 1735                 1740             


Glu Val  Leu Ala His Lys Ile  Arg Ala Val Glu Lys  Lys Pro Ile 
    1745                 1750                 1755             


Pro Arg  Ile Lys Arg Lys Asn  Asn Ser Thr Thr Thr  Asn Asn Ser 
    1760                 1765                 1770             


Lys Pro  Ser Ser Leu Pro Thr  Leu Gly Ser Asn Thr  Glu Thr Val 
    1775                 1780                 1785             


Gln Pro  Glu Val Lys Ser Glu  Thr Glu Pro His Phe  Ile Leu Lys 
    1790                 1795                 1800             


Ser Ser  Asp Asn Thr Lys Thr  Tyr Ser Leu Met Pro  Ser Ala Pro 
    1805                 1810                 1815             


His Pro  Val Lys Glu Ala Ser  Pro Gly Phe Ser Trp  Ser Pro Lys 
    1820                 1825                 1830             


Thr Ala  Ser Ala Thr Pro Ala  Pro Leu Lys Asn Asp  Ala Thr Ala 
    1835                 1840                 1845             


Ser Cys  Gly Phe Ser Glu Arg  Ser Ser Thr Pro His  Cys Thr Met 
    1850                 1855                 1860             


Pro Ser  Gly Arg Leu Ser Gly  Ala Asn Ala Ala Ala  Ala Asp Gly 
    1865                 1870                 1875             


Pro Gly  Ile Ser Gln Leu Gly  Glu Val Ala Pro Leu  Pro Thr Leu 
    1880                 1885                 1890             


Ser Ala  Pro Val Met Glu Pro  Leu Ile Asn Ser Glu  Pro Ser Thr 
    1895                 1900                 1905             


Gly Val  Thr Glu Pro Leu Thr  Pro His Gln Pro Asn  His Gln Pro 
    1910                 1915                 1920             


Ser Phe  Leu Thr Ser Pro Gln  Asp Leu Ala Ser Ser  Pro Met Glu 
    1925                 1930                 1935             


Glu Asp  Glu Gln His Ser Glu  Ala Asp Glu Pro Pro  Ser Asp Glu 
    1940                 1945                 1950             


Pro Leu  Ser Asp Asp Pro Leu  Ser Pro Ala Glu Glu  Lys Leu Pro 
    1955                 1960                 1965             


His Ile  Asp Glu Tyr Trp Ser  Asp Ser Glu His Ile  Phe Leu Asp 
    1970                 1975                 1980             


Ala Asn  Ile Gly Gly Val Ala  Ile Ala Pro Ala His  Gly Ser Val 
    1985                 1990                 1995             


Leu Ile  Glu Cys Ala Arg Arg  Glu Leu His Ala Thr  Thr Pro Val 
    2000                 2005                 2010             


Glu His  Pro Asn Arg Asn His  Pro Thr Arg Leu Ser  Leu Val Phe 
    2015                 2020                 2025             


Tyr Gln  His Lys Asn Leu Asn  Lys Pro Gln His Gly  Phe Glu Leu 
    2030                 2035                 2040             


Asn Lys  Ile Lys Phe Glu Ala  Lys Glu Ala Lys Asn  Lys Lys Met 
    2045                 2050                 2055             


Lys Ala  Ser Glu Gln Lys Asp  Gln Ala Ala Asn Glu  Gly Pro Glu 
    2060                 2065                 2070             


Gln Ser  Ser Glu Val Asn Glu  Leu Asn Gln Ile Pro  Ser His Lys 
    2075                 2080                 2085             


Ala Leu  Thr Leu Thr His Asp  Asn Val Val Thr Val  Ser Pro Tyr 
    2090                 2095                 2100             


Ala Leu  Thr His Val Ala Gly  Pro Tyr Asn His Trp  Val 
    2105                 2110                 2115     


<210>  104
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  104

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser 
    130                 135                 140                 


Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 
145                 150                 155                 160 


Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 
                165                 170                 175     


Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 
            180                 185                 190         


Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 
        195                 200                 205             


Ser Glu Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Gly Ser Asp 
    210                 215                 220                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
225                 230                 235                 240 


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
                245                 250                 255     


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
            260                 265                 270         


Leu Ala Ser Gly Ser Gly Pro Lys Lys Lys Arg Lys Val 
        275                 280                 285 


<210>  105
<211>  562
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  105

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser 
    130                 135                 140                 


Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 
145                 150                 155                 160 


Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 
                165                 170                 175     


Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 
            180                 185                 190         


Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 
        195                 200                 205             


Ser Glu Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Gly Ser Asp 
    210                 215                 220                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
225                 230                 235                 240 


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
                245                 250                 255     


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
            260                 265                 270         


Leu Ile Asn Ser Arg Ser Ser Gly Ser Pro Lys Lys Lys Arg Lys Val 
        275                 280                 285             


Gly Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu 
    290                 295                 300                 


Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser 
305                 310                 315                 320 


Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala 
                325                 330                 335     


Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro 
            340                 345                 350         


Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro 
        355                 360                 365             


Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala 
    370                 375                 380                 


Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala 
385                 390                 395                 400 


Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val 
                405                 410                 415     


Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro 
            420                 425                 430         


Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln 
        435                 440                 445             


Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro 
    450                 455                 460                 


Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln 
465                 470                 475                 480 


Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met 
                485                 490                 495     


Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln 
            500                 505                 510         


Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro 
        515                 520                 525             


Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met 
    530                 535                 540                 


Asp Phe Ser Ala Leu Leu Ala Ser Gly Ser Gly Pro Lys Lys Lys Arg 
545                 550                 555                 560 


Lys Val 
        


<210>  106
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  106

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser 
    130                 135                 140                 


Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 
145                 150                 155                 160 


Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 
                165                 170                 175     


Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 
            180                 185                 190         


Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 
        195                 200                 205             


Ser Glu Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Gly Ser Asp 
    210                 215                 220                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
225                 230                 235                 240 


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
                245                 250                 255     


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
            260                 265                 270         


Leu Ile Asn Ser Arg Ser Ser Gly Ser Pro Lys Lys Lys Arg Lys Val 
        275                 280                 285             


Gly Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu 
    290                 295                 300                 


Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser 
305                 310                 315                 320 


Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala 
                325                 330                 335     


Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro 
            340                 345                 350         


Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro 
        355                 360                 365             


Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala 
    370                 375                 380                 


Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala 
385                 390                 395                 400 


Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val 
                405                 410                 415     


Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro 
            420                 425                 430         


Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln 
        435                 440                 445             


Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro 
    450                 455                 460                 


Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln 
465                 470                 475                 480 


Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met 
                485                 490                 495     


Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln 
            500                 505                 510         


Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro 
        515                 520                 525             


Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met 
    530                 535                 540                 


Asp Phe Ser Ala Leu Leu Gly Ser Gly Ser Gly Ser Arg Asp Ser Arg 
545                 550                 555                 560 


Glu Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp 
                565                 570                 575     


Val Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile Arg Pro Phe 
            580                 585                 590         


His Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu 
        595                 600                 605             


Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val Gly Ser Leu Thr 
    610                 615                 620                 


Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala Val Thr Pro 
625                 630                 635                 640 


Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala 
                645                 650                 655     


Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro Gln Lys Glu 
            660                 665                 670         


Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro Pro Pro Arg 
        675                 680                 685             


Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met Thr Glu Asp 
    690                 695                 700                 


Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp 
705                 710                 715                 720 


Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met His Ile Ser Thr 
                725                 730                 735     


Gly Leu Ser Ile Phe Asp Thr Ser Leu Phe Ala Ser Gly Ser Gly Pro 
            740                 745                 750         


Lys Lys Lys Arg Lys Val 
        755             


<210>  107
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  107

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser 
    130                 135                 140                 


Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 
145                 150                 155                 160 


Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 
                165                 170                 175     


Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 
            180                 185                 190         


Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 
        195                 200                 205             


Ser Glu Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Gly Ser Ser 
    210                 215                 220                 


Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg 
225                 230                 235                 240 


Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe 
                245                 250                 255     


Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro 
            260                 265                 270         


Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro 
        275                 280                 285             


Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met 
    290                 295                 300                 


Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala 
305                 310                 315                 320 


Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala 
                325                 330                 335     


Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala 
            340                 345                 350         


Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln 
        355                 360                 365             


Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp 
    370                 375                 380                 


Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val 
385                 390                 395                 400 


Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu 
                405                 410                 415     


Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met 
            420                 425                 430         


Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro 
        435                 440                 445             


Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly 
    450                 455                 460                 


Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe 
465                 470                 475                 480 


Ser Ala Leu Leu Ala Ser Gly Ser Gly Pro Lys Lys Lys Arg Lys Val 
                485                 490                 495     


<210>  108
<211>  425
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  108

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser 
    130                 135                 140                 


Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 
145                 150                 155                 160 


Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 
                165                 170                 175     


Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 
            180                 185                 190         


Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 
        195                 200                 205             


Ser Glu Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Gly Ser Arg 
    210                 215                 220                 


Asp Ser Arg Glu Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala 
225                 230                 235                 240 


Ile Ser Asp Val Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile 
                245                 250                 255     


Arg Pro Phe His Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro 
            260                 265                 270         


Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val Gly 
        275                 280                 285             


Ser Leu Thr Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala 
    290                 295                 300                 


Val Thr Pro Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr 
305                 310                 315                 320 


Ser Gln Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro 
                325                 330                 335     


Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro 
            340                 345                 350         


Pro Pro Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met 
        355                 360                 365             


Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu 
    370                 375                 380                 


Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met His 
385                 390                 395                 400 


Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr Ser Leu Phe Ala Ser Gly 
                405                 410                 415     


Ser Gly Pro Lys Lys Lys Arg Lys Val 
            420                 425 


<210>  109
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  109

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser 
    130                 135                 140                 


Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 
145                 150                 155                 160 


Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 
                165                 170                 175     


Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 
            180                 185                 190         


Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 
        195                 200                 205             


Ser Glu Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Gly Ser Ser 
    210                 215                 220                 


Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg 
225                 230                 235                 240 


Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe 
                245                 250                 255     


Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro 
            260                 265                 270         


Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro 
        275                 280                 285             


Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met 
    290                 295                 300                 


Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala 
305                 310                 315                 320 


Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala 
                325                 330                 335     


Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala 
            340                 345                 350         


Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln 
        355                 360                 365             


Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp 
    370                 375                 380                 


Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val 
385                 390                 395                 400 


Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu 
                405                 410                 415     


Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met 
            420                 425                 430         


Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro 
        435                 440                 445             


Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly 
    450                 455                 460                 


Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe 
465                 470                 475                 480 


Ser Ala Leu Leu Gly Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly 
                485                 490                 495     


Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe 
            500                 505                 510         


Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro 
        515                 520                 525             


Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro 
    530                 535                 540                 


Thr Pro Thr Gly Pro Val His Glu Pro Val Gly Ser Leu Thr Pro Ala 
545                 550                 555                 560 


Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala 
                565                 570                 575     


Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys 
            580                 585                 590         


Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala 
        595                 600                 605             


Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly His 
    610                 615                 620                 


Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn 
625                 630                 635                 640 


Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe 
                645                 650                 655     


Leu Asn Asp Glu Cys Leu Leu His Ala Met His Ile Ser Thr Gly Leu 
            660                 665                 670         


Ser Ile Phe Asp Thr Ser Leu Phe Ala Ser Gly Ser Gly Pro Lys Lys 
        675                 680                 685             


Lys Arg Lys Val 
    690         


<210>  110
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  110

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu 
            20                  25                  30          


Trp Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser 
        35                  40                  45              


Val Arg Gln Ser Ser Ala Gln Lys Arg Lys Tyr Thr Ile Lys Val Glu 
    50                  55                  60                  


Val Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val 
65                  70                  75                  80  


Ala Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe 
                85                  90                  95      


Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu 
            100                 105                 110         


Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly 
        115                 120                 125             


Ile Tyr Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser 
    130                 135                 140                 


Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 
145                 150                 155                 160 


Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 
                165                 170                 175     


Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 
            180                 185                 190         


Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 
        195                 200                 205             


Ser Glu Gly Ser Gly Pro Lys Lys Lys Arg Lys Val Ala Gly Ser Ala 
    210                 215                 220                 


Ser Gly Ser Gly Pro Lys Lys Lys Arg Lys Val 
225                 230                 235 


<210>  111
<211>  2132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  111

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Gly Gly  Gly Gly Ser Pro Lys  Lys Lys Arg Lys Val  Asp Pro Lys 
    1370                 1375                 1380             


Lys Lys  Arg Lys Val Asp Pro  Lys Lys Lys Arg Lys  Val Gly Ser 
    1385                 1390                 1395             


Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 
    1400                 1405                 1410             


Ser Leu  Pro Thr Cys Ser Cys  Leu Asp Arg Val Ile  Gln Lys Asp 
    1415                 1420                 1425             


Lys Gly  Pro Tyr Tyr Thr His  Leu Gly Ala Gly Pro  Ser Val Ala 
    1430                 1435                 1440             


Ala Val  Arg Glu Ile Met Glu  Asn Arg Tyr Gly Gln  Lys Gly Asn 
    1445                 1450                 1455             


Ala Ile  Arg Ile Glu Ile Val  Val Tyr Thr Gly Lys  Glu Gly Lys 
    1460                 1465                 1470             


Ser Ser  His Gly Cys Pro Ile  Ala Lys Trp Val Leu  Arg Arg Ser 
    1475                 1480                 1485             


Ser Asp  Glu Glu Lys Val Leu  Cys Leu Val Arg Gln  Arg Thr Gly 
    1490                 1495                 1500             


His His  Cys Pro Thr Ala Val  Met Val Val Leu Ile  Met Val Trp 
    1505                 1510                 1515             


Asp Gly  Ile Pro Leu Pro Met  Ala Asp Arg Leu Tyr  Thr Glu Leu 
    1520                 1525                 1530             


Thr Glu  Asn Leu Lys Ser Tyr  Asn Gly His Pro Thr  Asp Arg Arg 
    1535                 1540                 1545             


Cys Thr  Leu Asn Glu Asn Arg  Thr Cys Thr Cys Gln  Gly Ile Asp 
    1550                 1555                 1560             


Pro Glu  Thr Cys Gly Ala Ser  Phe Ser Phe Gly Cys  Ser Trp Ser 
    1565                 1570                 1575             


Met Tyr  Phe Asn Gly Cys Lys  Phe Gly Arg Ser Pro  Ser Pro Arg 
    1580                 1585                 1590             


Arg Phe  Arg Ile Asp Pro Ser  Ser Pro Leu His Glu  Lys Asn Leu 
    1595                 1600                 1605             


Glu Asp  Asn Leu Gln Ser Leu  Ala Thr Arg Leu Ala  Pro Ile Tyr 
    1610                 1615                 1620             


Lys Gln  Tyr Ala Pro Val Ala  Tyr Gln Asn Gln Val  Glu Tyr Glu 
    1625                 1630                 1635             


Asn Val  Ala Arg Glu Cys Arg  Leu Gly Ser Lys Glu  Gly Arg Pro 
    1640                 1645                 1650             


Phe Ser  Gly Val Thr Ala Cys  Leu Asp Phe Cys Ala  His Pro His 
    1655                 1660                 1665             


Arg Asp  Ile His Asn Met Asn  Asn Gly Ser Thr Val  Val Cys Thr 
    1670                 1675                 1680             


Leu Thr  Arg Glu Asp Asn Arg  Ser Leu Gly Val Ile  Pro Gln Asp 
    1685                 1690                 1695             


Glu Gln  Leu His Val Leu Pro  Leu Tyr Lys Leu Ser  Asp Thr Asp 
    1700                 1705                 1710             


Glu Phe  Gly Ser Lys Glu Gly  Met Glu Ala Lys Ile  Lys Ser Gly 
    1715                 1720                 1725             


Ala Ile  Glu Val Leu Ala Pro  Arg Arg Lys Lys Arg  Thr Cys Phe 
    1730                 1735                 1740             


Thr Gln  Pro Val Pro Arg Ser  Gly Lys Lys Arg Ala  Ala Met Met 
    1745                 1750                 1755             


Thr Glu  Val Leu Ala His Lys  Ile Arg Ala Val Glu  Lys Lys Pro 
    1760                 1765                 1770             


Ile Pro  Arg Ile Lys Arg Lys  Asn Asn Ser Thr Thr  Thr Asn Asn 
    1775                 1780                 1785             


Ser Lys  Pro Ser Ser Leu Pro  Thr Leu Gly Ser Asn  Thr Glu Thr 
    1790                 1795                 1800             


Val Gln  Pro Glu Val Lys Ser  Glu Thr Glu Pro His  Phe Ile Leu 
    1805                 1810                 1815             


Lys Ser  Ser Asp Asn Thr Lys  Thr Tyr Ser Leu Met  Pro Ser Ala 
    1820                 1825                 1830             


Pro His  Pro Val Lys Glu Ala  Ser Pro Gly Phe Ser  Trp Ser Pro 
    1835                 1840                 1845             


Lys Thr  Ala Ser Ala Thr Pro  Ala Pro Leu Lys Asn  Asp Ala Thr 
    1850                 1855                 1860             


Ala Ser  Cys Gly Phe Ser Glu  Arg Ser Ser Thr Pro  His Cys Thr 
    1865                 1870                 1875             


Met Pro  Ser Gly Arg Leu Ser  Gly Ala Asn Ala Ala  Ala Ala Asp 
    1880                 1885                 1890             


Gly Pro  Gly Ile Ser Gln Leu  Gly Glu Val Ala Pro  Leu Pro Thr 
    1895                 1900                 1905             


Leu Ser  Ala Pro Val Met Glu  Pro Leu Ile Asn Ser  Glu Pro Ser 
    1910                 1915                 1920             


Thr Gly  Val Thr Glu Pro Leu  Thr Pro His Gln Pro  Asn His Gln 
    1925                 1930                 1935             


Pro Ser  Phe Leu Thr Ser Pro  Gln Asp Leu Ala Ser  Ser Pro Met 
    1940                 1945                 1950             


Glu Glu  Asp Glu Gln His Ser  Glu Ala Asp Glu Pro  Pro Ser Asp 
    1955                 1960                 1965             


Glu Pro  Leu Ser Asp Asp Pro  Leu Ser Pro Ala Glu  Glu Lys Leu 
    1970                 1975                 1980             


Pro His  Ile Asp Glu Tyr Trp  Ser Asp Ser Glu His  Ile Phe Leu 
    1985                 1990                 1995             


Asp Ala  Asn Ile Gly Gly Val  Ala Ile Ala Pro Ala  His Gly Ser 
    2000                 2005                 2010             


Val Leu  Ile Glu Cys Ala Arg  Arg Glu Leu His Ala  Thr Thr Pro 
    2015                 2020                 2025             


Val Glu  His Pro Asn Arg Asn  His Pro Thr Arg Leu  Ser Leu Val 
    2030                 2035                 2040             


Phe Tyr  Gln His Lys Asn Leu  Asn Lys Pro Gln His  Gly Phe Glu 
    2045                 2050                 2055             


Leu Asn  Lys Ile Lys Phe Glu  Ala Lys Glu Ala Lys  Asn Lys Lys 
    2060                 2065                 2070             


Met Lys  Ala Ser Glu Gln Lys  Asp Gln Ala Ala Asn  Glu Gly Pro 
    2075                 2080                 2085             


Glu Gln  Ser Ser Glu Val Asn  Glu Leu Asn Gln Ile  Pro Ser His 
    2090                 2095                 2100             


Lys Ala  Leu Thr Leu Thr His  Asp Asn Val Val Thr  Val Ser Pro 
    2105                 2110                 2115             


Tyr Ala  Leu Thr His Val Ala  Gly Pro Tyr Asn His  Trp Val 
    2120                 2125                 2130         


<210>  112
<211>  2132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  112

Met Ala Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys Asp 
1               5                   10                  15      


Lys Gly Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser Val Ala Ala 
            20                  25                  30          


Val Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala Ile 
        35                  40                  45              


Arg Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser His 
    50                  55                  60                  


Gly Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu Glu 
65                  70                  75                  80  


Lys Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro Thr 
                85                  90                  95      


Ala Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu Pro 
            100                 105                 110         


Met Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser Tyr 
        115                 120                 125             


Asn Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg Thr 
    130                 135                 140                 


Cys Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe Ser 
145                 150                 155                 160 


Phe Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly Arg 
                165                 170                 175     


Ser Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu His 
            180                 185                 190         


Glu Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu Ala 
        195                 200                 205             


Pro Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val Glu 
    210                 215                 220                 


Tyr Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly Arg 
225                 230                 235                 240 


Pro Phe Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro His 
                245                 250                 255     


Arg Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr Leu 
            260                 265                 270         


Thr Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu Gln 
        275                 280                 285             


Leu His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe Gly 
    290                 295                 300                 


Ser Lys Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala Ile Glu Val 
305                 310                 315                 320 


Leu Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val Pro 
                325                 330                 335     


Arg Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala His 
            340                 345                 350         


Lys Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg Lys 
        355                 360                 365             


Asn Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro Thr 
    370                 375                 380                 


Leu Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu Thr 
385                 390                 395                 400 


Glu Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr Ser 
                405                 410                 415     


Leu Met Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser Pro Gly Phe 
            420                 425                 430         


Ser Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys Asn 
        435                 440                 445             


Asp Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro His 
    450                 455                 460                 


Cys Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala Ala 
465                 470                 475                 480 


Asp Gly Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro Leu Pro Thr 
                485                 490                 495     


Leu Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser Thr 
            500                 505                 510         


Gly Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro Ser 
        515                 520                 525             


Phe Leu Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu Asp 
    530                 535                 540                 


Glu Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu Ser 
545                 550                 555                 560 


Asp Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp Glu 
                565                 570                 575     


Tyr Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly Gly 
            580                 585                 590         


Val Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala Arg 
        595                 600                 605             


Arg Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn His 
    610                 615                 620                 


Pro Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn Lys 
625                 630                 635                 640 


Pro Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys Glu 
                645                 650                 655     


Ala Lys Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala Ala 
            660                 665                 670         


Asn Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln Ile 
        675                 680                 685             


Pro Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr Val 
    690                 695                 700                 


Ser Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp Val 
705                 710                 715                 720 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
                725                 730                 735     


Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            740                 745                 750         


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        755                 760                 765             


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    770                 775                 780                 


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
785                 790                 795                 800 


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                805                 810                 815     


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            820                 825                 830         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        835                 840                 845             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    850                 855                 860                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
865                 870                 875                 880 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                885                 890                 895     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            900                 905                 910         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        915                 920                 925             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    930                 935                 940                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
945                 950                 955                 960 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                965                 970                 975     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            980                 985                 990         


Asp Leu Ala Glu Asp Ala Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp 
        995                 1000                 1005             


Asp Asp  Leu Asp Asn Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala 
    1010                 1015                 1020             


Asp Leu  Phe Leu Ala Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu 
    1025                 1030                 1035             


Ser Asp  Ile Leu Arg Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu 
    1040                 1045                 1050             


Ser Ala  Ser Met Ile Lys Arg  Tyr Asp Glu His His  Gln Asp Leu 
    1055                 1060                 1065             


Thr Leu  Leu Lys Ala Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr 
    1070                 1075                 1080             


Lys Glu  Ile Phe Phe Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr 
    1085                 1090                 1095             


Ile Asp  Gly Gly Ala Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys 
    1100                 1105                 1110             


Pro Ile  Leu Glu Lys Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys 
    1115                 1120                 1125             


Leu Asn  Arg Glu Asp Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn 
    1130                 1135                 1140             


Gly Ser  Ile Pro His Gln Ile  His Leu Gly Glu Leu  His Ala Ile 
    1145                 1150                 1155             


Leu Arg  Arg Gln Glu Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg 
    1160                 1165                 1170             


Glu Lys  Ile Glu Lys Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val 
    1175                 1180                 1185             


Gly Pro  Leu Ala Arg Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg 
    1190                 1195                 1200             


Lys Ser  Glu Glu Thr Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val 
    1205                 1210                 1215             


Asp Lys  Gly Ala Ser Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn 
    1220                 1225                 1230             


Phe Asp  Lys Asn Leu Pro Asn  Glu Lys Val Leu Pro  Lys His Ser 
    1235                 1240                 1245             


Leu Leu  Tyr Glu Tyr Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val 
    1250                 1255                 1260             


Lys Tyr  Val Thr Glu Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly 
    1265                 1270                 1275             


Glu Gln  Lys Lys Ala Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg 
    1280                 1285                 1290             


Lys Val  Thr Val Lys Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile 
    1295                 1300                 1305             


Glu Cys  Phe Asp Ser Val Glu  Ile Ser Gly Val Glu  Asp Arg Phe 
    1310                 1315                 1320             


Asn Ala  Ser Leu Gly Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys 
    1325                 1330                 1335             


Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu 
    1340                 1345                 1350             


Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile 
    1355                 1360                 1365             


Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val 
    1370                 1375                 1380             


Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu 
    1385                 1390                 1395             


Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys 
    1400                 1405                 1410             


Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn 
    1415                 1420                 1425             


Phe Met  Gln Leu Ile His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp 
    1430                 1435                 1440             


Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly Asp Ser  Leu His Glu 
    1445                 1450                 1455             


His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile 
    1460                 1465                 1470             


Leu Gln  Thr Val Lys Val Val  Asp Glu Leu Val Lys  Val Met Gly 
    1475                 1480                 1485             


Arg His  Lys Pro Glu Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn 
    1490                 1495                 1500             


Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys 
    1505                 1510                 1515             


Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys 
    1520                 1525                 1530             


Glu His  Pro Val Glu Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr 
    1535                 1540                 1545             


Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu 
    1550                 1555                 1560             


Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp Val Asp  Ala Ile Val 
    1565                 1570                 1575             


Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
    1580                 1585                 1590             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1595                 1600                 1605             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1610                 1615                 1620             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1625                 1630                 1635             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1640                 1645                 1650             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1655                 1660                 1665             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1670                 1675                 1680             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1685                 1690                 1695             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1700                 1705                 1710             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1715                 1720                 1725             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1730                 1735                 1740             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1745                 1750                 1755             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1760                 1765                 1770             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1775                 1780                 1785             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1790                 1795                 1800             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1805                 1810                 1815             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1820                 1825                 1830             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1835                 1840                 1845             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1850                 1855                 1860             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1865                 1870                 1875             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1880                 1885                 1890             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1895                 1900                 1905             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1910                 1915                 1920             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1925                 1930                 1935             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1940                 1945                 1950             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1955                 1960                 1965             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1970                 1975                 1980             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1985                 1990                 1995             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    2000                 2005                 2010             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    2015                 2020                 2025             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    2030                 2035                 2040             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    2045                 2050                 2055             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    2060                 2065                 2070             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    2075                 2080                 2085             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    2090                 2095                 2100             


Asp Gly  Gly Gly Gly Ser Pro  Lys Lys Lys Arg Lys  Val Asp Pro 
    2105                 2110                 2115             


Lys Lys  Lys Arg Lys Val Asp  Pro Lys Lys Lys Arg  Lys Val 
    2120                 2125                 2130         


<210>  113
<211>  2196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  113

Met Ala Leu Pro Thr Cys Ser Cys Leu Asp Arg Val Ile Gln Lys Asp 
1               5                   10                  15      


Lys Gly Pro Tyr Tyr Thr His Leu Gly Ala Gly Pro Ser Val Ala Ala 
            20                  25                  30          


Val Arg Glu Ile Met Glu Asn Arg Tyr Gly Gln Lys Gly Asn Ala Ile 
        35                  40                  45              


Arg Ile Glu Ile Val Val Tyr Thr Gly Lys Glu Gly Lys Ser Ser His 
    50                  55                  60                  


Gly Cys Pro Ile Ala Lys Trp Val Leu Arg Arg Ser Ser Asp Glu Glu 
65                  70                  75                  80  


Lys Val Leu Cys Leu Val Arg Gln Arg Thr Gly His His Cys Pro Thr 
                85                  90                  95      


Ala Val Met Val Val Leu Ile Met Val Trp Asp Gly Ile Pro Leu Pro 
            100                 105                 110         


Met Ala Asp Arg Leu Tyr Thr Glu Leu Thr Glu Asn Leu Lys Ser Tyr 
        115                 120                 125             


Asn Gly His Pro Thr Asp Arg Arg Cys Thr Leu Asn Glu Asn Arg Thr 
    130                 135                 140                 


Cys Thr Cys Gln Gly Ile Asp Pro Glu Thr Cys Gly Ala Ser Phe Ser 
145                 150                 155                 160 


Phe Gly Cys Ser Trp Ser Met Tyr Phe Asn Gly Cys Lys Phe Gly Arg 
                165                 170                 175     


Ser Pro Ser Pro Arg Arg Phe Arg Ile Asp Pro Ser Ser Pro Leu His 
            180                 185                 190         


Glu Lys Asn Leu Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu Ala 
        195                 200                 205             


Pro Ile Tyr Lys Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val Glu 
    210                 215                 220                 


Tyr Glu Asn Val Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly Arg 
225                 230                 235                 240 


Pro Phe Ser Gly Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro His 
                245                 250                 255     


Arg Asp Ile His Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr Leu 
            260                 265                 270         


Thr Arg Glu Asp Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu Gln 
        275                 280                 285             


Leu His Val Leu Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe Gly 
    290                 295                 300                 


Ser Lys Glu Gly Met Glu Ala Lys Ile Lys Ser Gly Ala Ile Glu Val 
305                 310                 315                 320 


Leu Ala Pro Arg Arg Lys Lys Arg Thr Cys Phe Thr Gln Pro Val Pro 
                325                 330                 335     


Arg Ser Gly Lys Lys Arg Ala Ala Met Met Thr Glu Val Leu Ala His 
            340                 345                 350         


Lys Ile Arg Ala Val Glu Lys Lys Pro Ile Pro Arg Ile Lys Arg Lys 
        355                 360                 365             


Asn Asn Ser Thr Thr Thr Asn Asn Ser Lys Pro Ser Ser Leu Pro Thr 
    370                 375                 380                 


Leu Gly Ser Asn Thr Glu Thr Val Gln Pro Glu Val Lys Ser Glu Thr 
385                 390                 395                 400 


Glu Pro His Phe Ile Leu Lys Ser Ser Asp Asn Thr Lys Thr Tyr Ser 
                405                 410                 415     


Leu Met Pro Ser Ala Pro His Pro Val Lys Glu Ala Ser Pro Gly Phe 
            420                 425                 430         


Ser Trp Ser Pro Lys Thr Ala Ser Ala Thr Pro Ala Pro Leu Lys Asn 
        435                 440                 445             


Asp Ala Thr Ala Ser Cys Gly Phe Ser Glu Arg Ser Ser Thr Pro His 
    450                 455                 460                 


Cys Thr Met Pro Ser Gly Arg Leu Ser Gly Ala Asn Ala Ala Ala Ala 
465                 470                 475                 480 


Asp Gly Pro Gly Ile Ser Gln Leu Gly Glu Val Ala Pro Leu Pro Thr 
                485                 490                 495     


Leu Ser Ala Pro Val Met Glu Pro Leu Ile Asn Ser Glu Pro Ser Thr 
            500                 505                 510         


Gly Val Thr Glu Pro Leu Thr Pro His Gln Pro Asn His Gln Pro Ser 
        515                 520                 525             


Phe Leu Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu Asp 
    530                 535                 540                 


Glu Gln His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu Ser 
545                 550                 555                 560 


Asp Asp Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp Glu 
                565                 570                 575     


Tyr Trp Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly Gly 
            580                 585                 590         


Val Ala Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala Arg 
        595                 600                 605             


Arg Glu Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn His 
    610                 615                 620                 


Pro Thr Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn Lys 
625                 630                 635                 640 


Pro Gln His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys Glu 
                645                 650                 655     


Ala Lys Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala Ala 
            660                 665                 670         


Asn Glu Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln Ile 
        675                 680                 685             


Pro Ser His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr Val 
    690                 695                 700                 


Ser Pro Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp Val 
705                 710                 715                 720 


Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Gly Gly Ser Pro Ala 
                725                 730                 735     


Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 
            740                 745                 750         


Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 
        755                 760                 765             


Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 
    770                 775                 780                 


Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 
785                 790                 795                 800 


Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
                805                 810                 815     


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            820                 825                 830         


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        835                 840                 845             


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    850                 855                 860                 


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
865                 870                 875                 880 


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                885                 890                 895     


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            900                 905                 910         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        915                 920                 925             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    930                 935                 940                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
945                 950                 955                 960 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                965                 970                 975     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            980                 985                 990         


Asn Gln Leu Phe Glu Glu Asn Pro  Ile Asn Ala Ser Gly  Val Asp Ala 
        995                 1000                 1005             


Lys Ala  Ile Leu Ser Ala Arg  Leu Ser Lys Ser Arg  Arg Leu Glu 
    1010                 1015                 1020             


Asn Leu  Ile Ala Gln Leu Pro  Gly Glu Lys Lys Asn  Gly Leu Phe 
    1025                 1030                 1035             


Gly Asn  Leu Ile Ala Leu Ser  Leu Gly Leu Thr Pro  Asn Phe Lys 
    1040                 1045                 1050             


Ser Asn  Phe Asp Leu Ala Glu  Asp Ala Lys Leu Gln  Leu Ser Lys 
    1055                 1060                 1065             


Asp Thr  Tyr Asp Asp Asp Leu  Asp Asn Leu Leu Ala  Gln Ile Gly 
    1070                 1075                 1080             


Asp Gln  Tyr Ala Asp Leu Phe  Leu Ala Ala Lys Asn  Leu Ser Asp 
    1085                 1090                 1095             


Ala Ile  Leu Leu Ser Asp Ile  Leu Arg Val Asn Thr  Glu Ile Thr 
    1100                 1105                 1110             


Lys Ala  Pro Leu Ser Ala Ser  Met Ile Lys Arg Tyr  Asp Glu His 
    1115                 1120                 1125             


His Gln  Asp Leu Thr Leu Leu  Lys Ala Leu Val Arg  Gln Gln Leu 
    1130                 1135                 1140             


Pro Glu  Lys Tyr Lys Glu Ile  Phe Phe Asp Gln Ser  Lys Asn Gly 
    1145                 1150                 1155             


Tyr Ala  Gly Tyr Ile Asp Gly  Gly Ala Ser Gln Glu  Glu Phe Tyr 
    1160                 1165                 1170             


Lys Phe  Ile Lys Pro Ile Leu  Glu Lys Met Asp Gly  Thr Glu Glu 
    1175                 1180                 1185             


Leu Leu  Val Lys Leu Asn Arg  Glu Asp Leu Leu Arg  Lys Gln Arg 
    1190                 1195                 1200             


Thr Phe  Asp Asn Gly Ser Ile  Pro His Gln Ile His  Leu Gly Glu 
    1205                 1210                 1215             


Leu His  Ala Ile Leu Arg Arg  Gln Glu Asp Phe Tyr  Pro Phe Leu 
    1220                 1225                 1230             


Lys Asp  Asn Arg Glu Lys Ile  Glu Lys Ile Leu Thr  Phe Arg Ile 
    1235                 1240                 1245             


Pro Tyr  Tyr Val Gly Pro Leu  Ala Arg Gly Asn Ser  Arg Phe Ala 
    1250                 1255                 1260             


Trp Met  Thr Arg Lys Ser Glu  Glu Thr Ile Thr Pro  Trp Asn Phe 
    1265                 1270                 1275             


Glu Glu  Val Val Asp Lys Gly  Ala Ser Ala Gln Ser  Phe Ile Glu 
    1280                 1285                 1290             


Arg Met  Thr Asn Phe Asp Lys  Asn Leu Pro Asn Glu  Lys Val Leu 
    1295                 1300                 1305             


Pro Lys  His Ser Leu Leu Tyr  Glu Tyr Phe Thr Val  Tyr Asn Glu 
    1310                 1315                 1320             


Leu Thr  Lys Val Lys Tyr Val  Thr Glu Gly Met Arg  Lys Pro Ala 
    1325                 1330                 1335             


Phe Leu  Ser Gly Glu Gln Lys  Lys Ala Ile Val Asp  Leu Leu Phe 
    1340                 1345                 1350             


Lys Thr  Asn Arg Lys Val Thr  Val Lys Gln Leu Lys  Glu Asp Tyr 
    1355                 1360                 1365             


Phe Lys  Lys Ile Glu Cys Phe  Asp Ser Val Glu Ile  Ser Gly Val 
    1370                 1375                 1380             


Glu Asp  Arg Phe Asn Ala Ser  Leu Gly Thr Tyr His  Asp Leu Leu 
    1385                 1390                 1395             


Lys Ile  Ile Lys Asp Lys Asp  Phe Leu Asp Asn Glu  Glu Asn Glu 
    1400                 1405                 1410             


Asp Ile  Leu Glu Asp Ile Val  Leu Thr Leu Thr Leu  Phe Glu Asp 
    1415                 1420                 1425             


Arg Glu  Met Ile Glu Glu Arg  Leu Lys Thr Tyr Ala  His Leu Phe 
    1430                 1435                 1440             


Asp Asp  Lys Val Met Lys Gln  Leu Lys Arg Arg Arg  Tyr Thr Gly 
    1445                 1450                 1455             


Trp Gly  Arg Leu Ser Arg Lys  Leu Ile Asn Gly Ile  Arg Asp Lys 
    1460                 1465                 1470             


Gln Ser  Gly Lys Thr Ile Leu  Asp Phe Leu Lys Ser  Asp Gly Phe 
    1475                 1480                 1485             


Ala Asn  Arg Asn Phe Met Gln  Leu Ile His Asp Asp  Ser Leu Thr 
    1490                 1495                 1500             


Phe Lys  Glu Asp Ile Gln Lys  Ala Gln Val Ser Gly  Gln Gly Asp 
    1505                 1510                 1515             


Ser Leu  His Glu His Ile Ala  Asn Leu Ala Gly Ser  Pro Ala Ile 
    1520                 1525                 1530             


Lys Lys  Gly Ile Leu Gln Thr  Val Lys Val Val Asp  Glu Leu Val 
    1535                 1540                 1545             


Lys Val  Met Gly Arg His Lys  Pro Glu Asn Ile Val  Ile Glu Met 
    1550                 1555                 1560             


Ala Arg  Glu Asn Gln Thr Thr  Gln Lys Gly Gln Lys  Asn Ser Arg 
    1565                 1570                 1575             


Glu Arg  Met Lys Arg Ile Glu  Glu Gly Ile Lys Glu  Leu Gly Ser 
    1580                 1585                 1590             


Gln Ile  Leu Lys Glu His Pro  Val Glu Asn Thr Gln  Leu Gln Asn 
    1595                 1600                 1605             


Glu Lys  Leu Tyr Leu Tyr Tyr  Leu Gln Asn Gly Arg  Asp Met Tyr 
    1610                 1615                 1620             


Val Asp  Gln Glu Leu Asp Ile  Asn Arg Leu Ser Asp  Tyr Asp Val 
    1625                 1630                 1635             


Asp Ala  Ile Val Pro Gln Ser  Phe Leu Lys Asp Asp  Ser Ile Asp 
    1640                 1645                 1650             


Asn Lys  Val Leu Thr Arg Ser  Asp Lys Asn Arg Gly  Lys Ser Asp 
    1655                 1660                 1665             


Asn Val  Pro Ser Glu Glu Val  Val Lys Lys Met Lys  Asn Tyr Trp 
    1670                 1675                 1680             


Arg Gln  Leu Leu Asn Ala Lys  Leu Ile Thr Gln Arg  Lys Phe Asp 
    1685                 1690                 1695             


Asn Leu  Thr Lys Ala Glu Arg  Gly Gly Leu Ser Glu  Leu Asp Lys 
    1700                 1705                 1710             


Ala Gly  Phe Ile Lys Arg Gln  Leu Val Glu Thr Arg  Gln Ile Thr 
    1715                 1720                 1725             


Lys His  Val Ala Gln Ile Leu  Asp Ser Arg Met Asn  Thr Lys Tyr 
    1730                 1735                 1740             


Asp Glu  Asn Asp Lys Leu Ile  Arg Glu Val Lys Val  Ile Thr Leu 
    1745                 1750                 1755             


Lys Ser  Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
    1760                 1765                 1770             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1775                 1780                 1785             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1790                 1795                 1800             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1805                 1810                 1815             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1820                 1825                 1830             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1835                 1840                 1845             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1850                 1855                 1860             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1865                 1870                 1875             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1880                 1885                 1890             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1895                 1900                 1905             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1910                 1915                 1920             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1925                 1930                 1935             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1940                 1945                 1950             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1955                 1960                 1965             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1970                 1975                 1980             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1985                 1990                 1995             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    2000                 2005                 2010             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    2015                 2020                 2025             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    2030                 2035                 2040             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    2045                 2050                 2055             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    2060                 2065                 2070             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    2075                 2080                 2085             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    2090                 2095                 2100             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    2105                 2110                 2115             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    2120                 2125                 2130             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    2135                 2140                 2145             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    2150                 2155                 2160             


Gln Leu  Gly Gly Asp Gly Gly  Gly Gly Ser Pro Lys  Lys Lys Arg 
    2165                 2170                 2175             


Lys Val  Asp Pro Lys Lys Lys  Arg Lys Val Asp Pro  Lys Lys Lys 
    2180                 2185                 2190             


Arg Lys  Val 
    2195     


<210>  114
<211>  113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  114
gacgctcaaa tttccgcagt gtttaagagc taagctggaa acagcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt ttt             113


<210>  115
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  115
gtttaagagc taagctggaa acagcatagc aagtttaaat aaggctagtc cgttatcaac       60

ttgaaaaagt ggcaccgagt cggtgctttt ttt                                    93


<210>  116
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  116
gacgctcaaa tttccgcagt                                                   20


<210>  117
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  117
gtttaagagc taagccaaca tgaggatcac ccatgtctgc agggcatagc aagtttaaat       60

aaggctagtc cgttatcaac ttggccaaca tgaggatcac ccatgtctgc agggccaagt      120

ggcaccgagt cggtgctttt ttt                                              143


<210>  118
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  118
taatacgact cactatagg                                                    19


<210>  119
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  119
agatcggaag agcacacgtc tgaactc                                           27


<210>  120
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  120
aucuuaggag uggcuccgg                                                    19


