                         SEQUENCE LISTING

<110>  EmendoBio Inc.
 
<120>  NOVEL OMNI-59, 61, 67, 76, 79, 80, 81 AND 82 CRISPR NUCLEASES

<130>  91412-A-PCT/GJG/AWG

<150>  63/034,610
<151>  2020-06-04

<150>  63/122,564
<151>  2020-12-08

<160>  243   

<170>  PatentIn version 3.5

<210>  1
<211>  1049
<212>  PRT
<213>  Comamonadaceae bacterium NML00-0135

<400>  1

Met Asn Val Trp Lys Gly Thr Gly Phe Val Ser Arg Lys Arg Asn Ile 
1               5                   10                  15      


Ile Arg Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr Ser Leu Gly Trp 
            20                  25                  30          


Ala Ile Leu Arg Leu Asn Ala Asp Asn Gln Pro Thr Ala Ile Leu Lys 
        35                  40                  45              


Ala Gly Val Arg Ile Phe Ser Asp Gly Arg Asn Pro Lys Asp Gly Ser 
    50                  55                  60                  


Ser Leu Ala Val Thr Arg Arg Ala Ala Arg Ala Met Arg Arg Arg Arg 
65                  70                  75                  80  


Asp Arg Leu Leu Lys Arg Lys Ala Arg Met Leu Asp Lys Leu Ile Ala 
                85                  90                  95      


His Gly Phe Phe Pro Gln Asp Glu Ala Ala Arg Lys Ala Leu Glu Val 
            100                 105                 110         


Leu Asn Pro Tyr Gln Leu Arg Ala Glu Gly Leu Gln Arg Ala Leu Met 
        115                 120                 125             


Pro Gly Glu Phe Ala Arg Ala Met Phe His Ile Asn Gln Arg Arg Gly 
    130                 135                 140                 


Phe Lys Ser Asn Arg Lys Thr Asp Lys Lys Asp Ser Asp Ser Gly Ala 
145                 150                 155                 160 


Leu Lys Thr Ala Ile Ser Gln Leu Arg Gln Gln Leu Gln Asn Glu Asn 
                165                 170                 175     


Ala Arg Thr Val Gly Glu Trp Leu Trp Gln Arg Leu Gln Ala Gly Gln 
            180                 185                 190         


Gly Thr Arg Ala Arg Tyr Arg Glu Thr Arg Ile Ala Thr Asp Thr Gly 
        195                 200                 205             


Lys Gly Lys Ile Asp Lys Ser Tyr Asp Leu Tyr Ile Asp Arg Gln Met 
    210                 215                 220                 


Val Ala Asp Glu Phe Asp Ala Leu Trp Ala Val Gln Ala Ala Phe Asn 
225                 230                 235                 240 


Pro Val Leu Phe Asn Glu Gln Ala Arg Ala Glu Leu Arg Asp Thr Leu 
                245                 250                 255     


Leu His Gln Arg Pro Leu Arg Pro Ala Lys Pro Gly Arg Cys Thr Leu 
            260                 265                 270         


Leu Pro Glu Glu Glu Arg Ala Pro Leu Ala Leu Pro Ser Thr Gln Arg 
        275                 280                 285             


Phe Arg Ile Leu Gln Glu Val Asn His Leu Arg Ile Leu His Pro Asp 
    290                 295                 300                 


Leu Arg Glu Glu Ala Leu Thr Leu Asp Arg Arg Asn Ala Ile Val Ala 
305                 310                 315                 320 


Leu Leu Glu Asn Arg Gly Lys Val Thr Phe Gln Ala Met Arg Arg Thr 
                325                 330                 335     


Leu Asn Leu Gly Asp Ala Val Gln Phe Asn Leu Glu Asp Ala Lys Arg 
            340                 345                 350         


Arg Glu Leu Lys Gly Asn Ala Thr Thr Ala Ala Leu Ser Lys Lys Glu 
        355                 360                 365             


Leu Phe Gly Ala Ala Trp His Asp Phe Asp Glu Ala Leu Gln Asp Asp 
    370                 375                 380                 


Ile Val Leu Arg Leu Val Thr Glu Glu Ser Glu Ala Glu Leu Val Gln 
385                 390                 395                 400 


Trp Leu Ile Glu Asn Thr Gly Val Asp Glu Ala Arg Ala Thr Ala Ile 
                405                 410                 415     


Ala Asn Thr Gly Leu Pro Glu Gly Tyr Gly Ser Leu Ser Arg Lys Ala 
            420                 425                 430         


Leu Ala Arg Ile Val Pro Ala Leu Arg Ala Glu Val Ile Thr Tyr Asp 
        435                 440                 445             


Lys Ala Val Gln Ala Ala Gly Phe Ala His His Ser Asp Leu Arg Phe 
    450                 455                 460                 


Ser Phe Glu Tyr Asp Ser Ala Asp Val Glu Gln Val Gly Glu Arg Ile 
465                 470                 475                 480 


Asp Lys Thr Thr Gly Glu Ile Leu Pro Val Ser Ala Phe Lys Gln Leu 
                485                 490                 495     


Pro Tyr Tyr Gly Lys Ala Leu Gln Arg His Val Ala Phe Gly Ser Gly 
            500                 505                 510         


Asn Pro Gln Asp Pro Glu Glu Lys Arg Tyr Gly Lys Ile Ala Asn Pro 
        515                 520                 525             


Thr Val His Ile Gly Leu Asn Gln Val Arg Arg Val Val Asn Asp Leu 
    530                 535                 540                 


Ile Arg Arg Tyr Gly Arg Pro Thr Glu Ile Val Val Glu Leu Ala Arg 
545                 550                 555                 560 


Glu Leu Lys Gln Ser Arg Glu Gln Lys Leu Glu Ala Gln Arg Lys Gln 
                565                 570                 575     


Ala Asp Asn Gln Lys Arg Asn Ala Arg Ile Arg Ala Glu Ile Ala Pro 
            580                 585                 590         


Ile Leu Gly Ile Ser Glu Glu Arg Val Lys His Ala Asp Ile Gln Lys 
        595                 600                 605             


Trp Ile Leu Trp Glu Glu Leu Ser Phe Asp Val Ala Asp Arg Arg Cys 
    610                 615                 620                 


Pro Tyr Ser Gly Val Gln Ile Ser Ala Arg Met Leu Leu Ser Asp Glu 
625                 630                 635                 640 


Val Glu Ile Glu His Ile Leu Pro Phe Ser Gln Thr Leu Asp Asp Ser 
                645                 650                 655     


Leu Asn Asn Lys Thr Val Ser Met Arg Gln Ala Asn Arg Ile Lys Gly 
            660                 665                 670         


Asn Arg Thr Pro Trp Gln Ala Arg Gln Asp Phe Glu Ala Gln Gly Trp 
        675                 680                 685             


Pro Tyr Glu Gly Met Gln Gln Arg Ala Glu Arg Met Pro Arg Ala Lys 
    690                 695                 700                 


Arg Tyr Arg Phe Ala Pro Asp Gly Tyr Glu Arg Trp Leu Gly Glu Asp 
705                 710                 715                 720 


Gln Gly Phe Leu Ala Arg Ala Leu Asn Asp Thr Arg Tyr Leu Ser Arg 
                725                 730                 735     


Ile Ala Arg Asp Tyr Leu Thr Leu Val Cys Pro Gly Gly Val Arg Val 
            740                 745                 750         


Ile Pro Gly Arg Met Thr Ala Leu Leu Arg Ala Lys Phe Gly Leu Asn 
        755                 760                 765             


Gly Val Leu Ser Leu Ser Gly Glu Lys Asn Arg Asp Asp His Arg His 
    770                 775                 780                 


His Ala Val Asp Ala Cys Val Ile Gly Val Thr Asp Gln Gly Leu Leu 
785                 790                 795                 800 


Gln Arg Phe Ala Glu Ala Ser Ala Met Ala Arg Gln Gln Gly Leu Glu 
                805                 810                 815     


Lys Leu Val Glu Thr Met Pro Leu Pro Trp Glu Thr Tyr Pro Ala His 
            820                 825                 830         


Val Gln Arg Ala Val Gln Asn Ile Trp Val Ser His Arg Pro Asp His 
        835                 840                 845             


Gly His Glu Gly Gly Met Met Glu Glu Thr Ser Tyr Gly Ile Ser Lys 
    850                 855                 860                 


Asp Gly Arg Ile Lys Gln Arg Arg Lys Ala Asp Gly Ser Gln Gly Arg 
865                 870                 875                 880 


Glu Ile Ser Asn Leu Ile Arg Ile Ser Glu Pro Ser Gln Pro Glu Arg 
                885                 890                 895     


His Gly Val Asp Ala Glu Gly Gln Pro Leu Pro Tyr Lys Gly Tyr Val 
            900                 905                 910         


Gly Gly Ser Asn Tyr Cys Ile Glu Ile Thr Arg Asn Asp Lys Gly Lys 
        915                 920                 925             


Trp Glu Gly Glu Val Ile Ser Thr Phe Arg Ala Tyr Gln Ile Val Arg 
    930                 935                 940                 


Lys His Gly Val Ala Arg Leu Arg His Pro Glu Met Ala Gln Asn Gly 
945                 950                 955                 960 


Lys Ala Leu Val Met Arg Leu Met Ile Asp Asp Cys Val Arg Leu Glu 
                965                 970                 975     


Leu Asp Gly Arg Glu Glu Thr Met Arg Val Val Val Ile Pro Arg Asn 
            980                 985                 990         


Gly Gln Val Phe Met Ala Pro Leu  His Glu Ala Asn Val  Asp Ala Arg 
        995                 1000                 1005             


Asn Arg  Asp Lys Asn Asp Pro  Phe Ser Tyr Ile Ser  Lys Met Ala 
    1010                 1015                 1020             


Gly Ser  Phe Leu Lys Ala Lys  Ala Arg His Ile Thr  Ile Ser Pro 
    1025                 1030                 1035             


Ile Gly  Glu Leu His Asp Pro  Gly Phe Lys Gly 
    1040                 1045                 


<210>  2
<211>  1021
<212>  PRT
<213>  Demequina sediminicola

<400>  2

Met Thr Gly Thr Asp Ala Thr Ala His Ser His Thr Pro Tyr Arg Leu 
1               5                   10                  15      


Gly Leu Asp Val Gly Thr Gly Ser Leu Gly Trp Ala Val Val Glu Leu 
            20                  25                  30          


Asp Thr Asp Gly Asn Pro Val Arg Ile Val Arg Thr Gly Ser Arg Ile 
        35                  40                  45              


Tyr Gly Ser Gly Arg Lys Pro Lys Asp Phe Ser Ser Leu Ala Ala Asp 
    50                  55                  60                  


Arg Arg Ala Ala Arg Gln Met Arg Lys Gln Arg Asp Arg Tyr Leu Gln 
65                  70                  75                  80  


Arg Arg Thr Arg Leu Met His Glu Leu Val Ala Ala Gly Leu Met Pro 
                85                  90                  95      


Glu Ala Glu Val Glu Arg Gln Lys Leu Lys Asp Leu Asn Pro Tyr Leu 
            100                 105                 110         


Leu Arg Ala Arg Gly Val Lys Glu Glu Leu Thr Ala His Glu Leu Gly 
        115                 120                 125             


Arg Ala Leu Phe His Leu Gln Gln Arg Arg Gly Phe Lys Ser Asn Arg 
    130                 135                 140                 


Lys Thr Asp Arg Lys Asp Asp Asp Arg Ser Ala Met Lys Ser Ala Ile 
145                 150                 155                 160 


Ala Ser Leu Gln Ser Asp Leu Gly Asp Asp Thr Leu Gly Thr Tyr Met 
                165                 170                 175     


Trp Lys Arg Ile Gln Asn Gly Glu Ser Val Arg Ser Arg Pro Arg Lys 
            180                 185                 190         


Val Gly Ser Lys Asn Glu Tyr Asp Phe Tyr Val Asn Arg Ala Met Val 
        195                 200                 205             


Glu Asp Glu Phe Asn Gln Leu Trp Asp Tyr Gln Ser Gln Ser His Gly 
    210                 215                 220                 


Asp Leu Leu Thr Asp Glu Ala Arg Ile Arg Val His Asp Ala Ile Phe 
225                 230                 235                 240 


Ser Gln Arg Pro Leu Lys Pro Val Asp Pro Gly Arg Cys Thr Phe Glu 
                245                 250                 255     


Thr Asp Gln Arg Arg Ala Pro Lys Ala Leu Pro Ser Ser Gln Leu Phe 
            260                 265                 270         


Arg Ile Tyr Gln Glu Leu Asn Ala Ile Arg Val Ile Asp Pro Phe Ser 
        275                 280                 285             


Ser Asp Gln Ala Asp Arg Pro Leu Thr Arg Gln Glu Arg Asp Ala Gly 
    290                 295                 300                 


Ala Ser Phe Leu Leu Gly Arg Val Lys Ala Thr Phe Pro Gln Leu Lys 
305                 310                 315                 320 


Lys Ala Met Phe Gly Pro Thr Lys Leu Gln Leu Ser Leu Glu Tyr Gly 
                325                 330                 335     


Glu Arg Lys Asn Ile Leu Gly Asp Val Val Gly Ser Glu Leu Arg Lys 
            340                 345                 350         


Ala Gln His Ile Gly Pro Asp Trp Glu Thr Tyr Asp Leu Ala Thr Gln 
        355                 360                 365             


Asp Leu Ile Val Thr Ile Leu Leu Glu Ala Asp Thr Asp Asp Glu Val 
    370                 375                 380                 


Ile Glu Arg Leu Gln Ala Glu Ser Ser Leu Ser Leu Asp Gln Val His 
385                 390                 395                 400 


Gly Ala Leu Glu Ala Pro Leu Pro Asp Asp Tyr Leu Arg Leu Ser His 
                405                 410                 415     


Arg Ala Ile Gly Lys Ile Leu Pro His Leu Lys Asp Glu Trp Asn Glu 
            420                 425                 430         


Glu Gly Asn Ala Pro Val Met Tyr Asp Ala Ala Val Arg Ala Ala Gly 
        435                 440                 445             


Tyr Gln Ser His Ser Glu Phe His Ser Gly Val Leu Glu Asp Thr Leu 
    450                 455                 460                 


Pro Tyr Tyr Gly Lys Val Leu Lys Arg Tyr Thr Gln Glu Val Ser Gly 
465                 470                 475                 480 


Ser Ser Gln Ala Ala Thr Asn Pro Asp Glu Trp Glu Phe Gly Lys Ile 
                485                 490                 495     


Ala Asn Pro Thr Val His Ile Gly Leu Asn Gln Ile Arg Thr Val Val 
            500                 505                 510         


Asn Ser Leu Ile Asp Arg Tyr Gly Leu Pro Thr Gln Ile His Val Glu 
        515                 520                 525             


Val Ala Arg Asp Leu Gly Gln Ser Ala Glu Gly Arg Arg Glu Ala Ala 
    530                 535                 540                 


Ser Asn Arg Ala Lys Asn Glu Arg Ala Asn Glu Ala Leu Asn Ala Arg 
545                 550                 555                 560 


Leu Thr Glu Leu Gly Gln Arg Thr Asn Phe Ala Asn Arg Glu Arg Leu 
                565                 570                 575     


Arg Leu Tyr Asp Glu Ile Ser Val Leu Asn His Arg Cys Val Leu Thr 
            580                 585                 590         


Gly Ile Pro Ile Glu Met Ser Arg Leu Phe Thr Asn Asp Tyr Gln Val 
        595                 600                 605             


Asp His Ile Leu Pro Phe Ser Arg Thr Leu Asp Asp Ser Arg Gly Asn 
    610                 615                 620                 


Lys Ile Leu Val His His Thr Ala Asn Gln Phe Lys Gly Ala Arg Ser 
625                 630                 635                 640 


Pro Phe Glu Ala Tyr Ser Glu Thr Ala Asp Trp Asp His Ile Leu Gln 
                645                 650                 655     


Arg Ala Ser Asp Ala Phe Gly Ala Thr Ser Pro Lys Phe Lys Arg Phe 
            660                 665                 670         


Ser Ala Asp Ala Met Asp Arg Tyr Ser Asn Gly Glu Gln Asp Phe Ile 
        675                 680                 685             


Ala Arg Gln Leu Asn Asp Thr Ser Tyr Leu Ala Arg Val Thr Arg Glu 
    690                 695                 700                 


Tyr Leu Gly Ser Ile Val Asp Pro Asp Arg Ile Leu Ala Thr Pro Gly 
705                 710                 715                 720 


Arg Leu Thr Ser Leu Leu Arg His His Trp Gly Leu Asn Gly Leu Leu 
                725                 730                 735     


Ser Asp Ala Ala Glu Lys Asn Arg Ser Asp His Arg His His Ala Ile 
            740                 745                 750         


Asp Ala Leu Val Val Ala Leu Ser Glu Arg Val Thr Leu Lys Ala Val 
        755                 760                 765             


Thr Asp Ala Asn Arg Arg Ala Gly Asp Gln Gly Ile Glu Arg Leu Leu 
    770                 775                 780                 


Val Asp Leu Pro Gln Pro Trp Glu Gly Phe Ala Asp His Ala Arg Glu 
785                 790                 795                 800 


Ser Val Asp Arg Ile Val Val Ser His Lys Pro Asp His Asn Glu Lys 
                805                 810                 815     


Gly Gln Leu His Glu Glu Thr Ala Tyr Gly Val Leu Glu Gly Pro Asp 
            820                 825                 830         


Lys Lys Gly Arg Phe Leu Thr Arg Lys Arg Ile Thr Asp Pro Ala Lys 
        835                 840                 845             


Gly Val Val Gly Ser Trp Glu Gln Pro Lys Trp Arg Asp Val Ile Pro 
    850                 855                 860                 


Leu Tyr Arg Arg Gly Glu Gly Pro Asp Ser Thr Leu Pro Tyr Lys Ala 
865                 870                 875                 880 


Tyr Ile Gly Gly Ser Asn Tyr Cys Ile Glu Ile Val Arg Thr Ala Lys 
                885                 890                 895     


Gly Lys Trp Ala Gly Glu Val Val Ser Thr His Thr Ala Asn Thr Ala 
            900                 905                 910         


Glu Tyr Arg Ala Phe Met Ala Glu Pro Gly Ala Tyr Arg Ala Gln Ser 
        915                 920                 925             


Tyr Ala Gly Gly Asp Leu Val Met Arg Leu Ile Ala Asn Asp Thr Ile 
    930                 935                 940                 


Ala Ile Glu Val Gly Asp Ala Gly Arg Gln Ile Met Arg Leu Cys Gln 
945                 950                 955                 960 


Leu Glu Thr Val Gly Ala Met Tyr Phe Ala Asn Val Arg Glu Gly Asn 
                965                 970                 975     


Val Ala Ala Arg Ser Arg Ala Arg Asp Asn Asp Phe Ser Leu Leu Lys 
            980                 985                 990         


Lys Ala Ala Ser Thr Leu Gln Pro  Leu Lys Ala Arg Arg  Val Phe Val 
        995                 1000                 1005             


Asp Pro  Ile Gly Arg Val Phe  Asp Pro Asp Phe Lys  Glu 
    1010                 1015                 1020     


<210>  3
<211>  1046
<212>  PRT
<213>  Fuerstia marisgermanicae

<400>  3

Met Asn Tyr Ile Leu Gly Leu Asp Leu Gly Ser Ala Ser Leu Gly Trp 
1               5                   10                  15      


Ala Val Leu Glu Cys Thr Glu Val Asp Gly Ser Leu Gln Pro Thr Arg 
            20                  25                  30          


Ile Glu Arg Thr Gly Val Arg Ile Phe Glu Ala Gly Val Glu Gly Asp 
        35                  40                  45              


Ile Glu Gln Gly Arg Asp Ala Ser Arg Ala Ala Lys Arg Arg Glu Ala 
    50                  55                  60                  


Arg Gln Pro Arg Arg Gln Asn Trp Arg Thr Gln Gln Arg Lys Arg Lys 
65                  70                  75                  80  


Leu Phe Arg Leu Leu Gln Gln His Gly Leu Leu Pro Ala Ser Glu Lys 
                85                  90                  95      


Asp Asp Ala Ile Ser Arg Lys Ala Val Phe Asp Gln Leu Asp Lys Glu 
            100                 105                 110         


Leu Thr Glu Lys His Ile Thr Glu Gly Asp His Thr Ala His Gln His 
        115                 120                 125             


Leu Pro Tyr Leu Leu Arg Met Leu Ala Ser Gly Ala Lys Val Lys Pro 
    130                 135                 140                 


Phe Glu Leu Gly Arg Ala Ile Tyr Ser Leu Ala Gln Arg Arg Gly Phe 
145                 150                 155                 160 


Leu Ser Asn Arg Lys Ala Asp Thr Asp Glu Lys Glu Asp Gly Val Val 
                165                 170                 175     


Lys Ala Ser Ile Ser Glu Leu Gly Gly Gln Ile Ala Gly Arg Thr Ile 
            180                 185                 190         


Ala Gln Thr Phe Val Glu Asp Ile Ser Pro Asp His Glu Asp Pro Gly 
        195                 200                 205             


Arg Gln Arg Ile Arg Gln Arg Tyr Thr Ala Arg Glu Met Phe His Asp 
    210                 215                 220                 


Glu Phe Asn Arg Ile Arg Lys Gln Gln Gln Pro His Phe Asp Leu Ala 
225                 230                 235                 240 


Asp Asn Asp Trp Asp Thr Val Tyr Lys Thr Ile Phe Phe Gln Arg Pro 
                245                 250                 255     


Leu Lys Ser Gln Arg His Arg Ile Gly Arg Cys Glu Ile Asp Gly Gly 
            260                 265                 270         


Gln Arg Cys Leu Asp Ala Leu Asp Val Phe Gln Gln Phe Arg Ile Trp 
        275                 280                 285             


His Ala Val Gln Asn Leu Arg Leu Ala Asp Ala Tyr Ser Leu Gly Arg 
    290                 295                 300                 


Asp Gly Arg Leu Thr Leu Glu Glu Gln Gln Lys Ile Val Asp Ala Leu 
305                 310                 315                 320 


Gln Thr Gln Ala Thr Met Thr Trp Gly Lys Val Val Thr Leu Leu Gly 
                325                 330                 335     


Leu Lys Arg Gly Thr Lys Phe Thr Ile Gln Glu Trp Asn Thr Lys Gly 
            340                 345                 350         


Leu Thr Gly His Arg Thr Asn Ser Ala Met Met His Val Phe Gly Asp 
        355                 360                 365             


Glu Trp Leu Asp Arg Pro Leu Glu Glu Arg Asp Ala Ile Thr Lys Glu 
    370                 375                 380                 


Val Val Tyr Phe Arg Lys Pro Ser Ala Met Arg Lys Arg Gly Gln Glu 
385                 390                 395                 400 


Ala Trp Gly Leu Ser Glu Glu Gln Ala Ala Leu Leu Pro Ser Thr Arg 
                405                 410                 415     


Leu Glu Glu Ala His Ala Arg His Ser Ala Ala Thr Leu Ala Ile Phe 
            420                 425                 430         


Val Glu Arg Met Ser Arg Gly Glu Asp Tyr Ser Thr Ile Arg Lys Asp 
        435                 440                 445             


Ile Thr Gly Lys Asp Asp Ser Glu Pro Leu Asp Gln Leu Pro Pro Leu 
    450                 455                 460                 


Ser Lys Ala Gly Leu Asp Ile Thr Asn Pro Ala Val Ile Arg Gly Leu 
465                 470                 475                 480 


Thr Glu Leu Arg Lys Val Val Asn Glu Leu Val Arg Gln Tyr Gly Lys 
                485                 490                 495     


Pro Ile Gly Ile Arg Ile Glu Leu Ser Arg Ser Leu Lys Asn Ser Arg 
            500                 505                 510         


Asp Lys Arg Ile Lys Leu His Lys Asp Asn Glu Asp Arg Arg Lys Arg 
        515                 520                 525             


Arg Glu Lys Ala Ile Glu Gly Ile Leu Lys Gln Ile Pro Gly Arg Tyr 
    530                 535                 540                 


Ser Gly Asn Asp Ile Glu Lys Trp Leu Leu Ala Glu Glu Cys Gly Trp 
545                 550                 555                 560 


His Cys Pro Tyr Thr Gly Arg Pro Ile Ser Pro Ser Thr Leu Leu Gly 
                565                 570                 575     


Ser Gln Pro Gln Phe Asp Ile Glu His Ile Phe Pro Arg Arg Tyr Leu 
            580                 585                 590         


Asp Asn Ser Phe Ser Asn Lys Thr Leu Cys Tyr His Glu Phe Asn Arg 
        595                 600                 605             


Asn Val Lys Lys Asn Gln Thr Ala Phe Asp Ala Cys Ser Gly Leu Asp 
    610                 615                 620                 


Ser Trp Asp Glu Ile Leu Gln Arg Val Asn Asn Phe Asp Gly Pro Val 
625                 630                 635                 640 


Ala Ala Leu Lys Arg Lys Arg Phe Leu Thr Ala Ala Lys Glu Ile Pro 
                645                 650                 655     


Asp Gly Phe Thr Ser Lys His Leu Asn Asp Asn Arg Tyr Asn Ala Val 
            660                 665                 670         


Val Ala Lys Lys Tyr Val Ala Met Leu Tyr Gly Gly Leu Ser Asp Ala 
        675                 680                 685             


Asp Gly Ser Gln Arg Val Phe Ala Val Thr Gly Gly His Thr Ala Leu 
    690                 695                 700                 


Leu Arg Arg Glu Trp Gly Leu Asn Ser Ile Leu Ser Gly Thr Glu Glu 
705                 710                 715                 720 


Lys Thr Arg Asp Asp His Arg His His Ala Val Asp Ala Val Val Ile 
                725                 730                 735     


Ala Leu Thr Asp Pro Ala Arg Ile Gln Ala Leu Val Asn Ala Ala Glu 
            740                 745                 750         


Leu Ala Glu Lys Lys Ala Ser Arg Arg Phe Tyr Glu Ala Val Gln Asp 
        755                 760                 765             


Pro Trp Pro Lys Phe Ser Ser Lys Val Ala Asp Ser Ile Asn Glu Ile 
    770                 775                 780                 


Val Val Ser His Arg Pro Thr Arg Thr Leu Pro Gly Ala Leu His Ala 
785                 790                 795                 800 


Glu Ser Ile Tyr Ser Lys Pro His Ile Asp Lys Asp Gly Asn Thr Asn 
                805                 810                 815     


His Arg Ile Arg Lys His Ile Thr Lys Leu Ser Ala Thr Glu Leu Lys 
            820                 825                 830         


Lys Asp Lys Ile Val Asp Pro Ala Ile Arg Asp Leu Val Lys Ala Lys 
        835                 840                 845             


Leu Lys Glu Leu Gly Glu Ser Asn Pro Ala Lys Ala Phe Ala Glu Glu 
    850                 855                 860                 


Lys Asn His Pro Phe Leu Thr Ala Lys Asp Gly Arg Lys Ile Pro Ile 
865                 870                 875                 880 


His Lys Val Arg Val Phe Ala Asp Lys Lys Pro Arg Ala Ile Ala Lys 
                885                 890                 895     


Asn Glu Arg Gln Arg Tyr Val Ala Ser Gly Lys Asp Ser Asn Phe Ala 
            900                 905                 910         


Ser Met Ile Tyr Ala Val Val Asp Lys Asp Gly His Glu Ile Lys Trp 
        915                 920                 925             


Glu His Lys Val Ile Thr Arg Leu Glu Ala His Glu Arg Lys Thr Arg 
    930                 935                 940                 


Asn Arg Thr Val Asn Gly Glu Lys Val Leu Leu Pro Asp Pro Thr Asp 
945                 950                 955                 960 


Phe Asn Asp Asp Lys Lys Arg Val Phe Lys Phe Ala Leu Cys Lys Asn 
                965                 970                 975     


Asp Thr Val Met Leu Glu Gly Pro Asp Gly Asp Asp Val Ile Cys Arg 
            980                 985                 990         


Ile Gln Lys Ile Ser Gln Ala Glu  Ile Gln Leu Cys Pro  Leu Ala Thr 
        995                 1000                 1005             


Pro Ser  Val Gln Gly Lys Ala  Arg Ser Lys Trp Asn  Gln Ile Gln 
    1010                 1015                 1020             


Ser Ile  Asp Asn Leu Arg Lys  Trp Asn Leu Arg Thr  Val Leu Ile 
    1025                 1030                 1035             


Ser Pro  Thr Gly Ile Glu His  Arg 
    1040                 1045     


<210>  4
<211>  1036
<212>  PRT
<213>  Nitrosomonas sp. Nm33

<400>  4

Met Leu His Lys Met Arg Tyr Arg Leu Ala Leu Asp Leu Gly Ser Thr 
1               5                   10                  15      


Ser Leu Gly Trp Ala Met Ile Arg Leu Asp Ala Asn Gln Arg Pro Cys 
            20                  25                  30          


Ala Val Ile Lys Ala Gly Val Arg Ile Phe Ser Asn Gly Arg Asn Pro 
        35                  40                  45              


Lys Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Glu Ala Arg Ala Met 
    50                  55                  60                  


Arg Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Ala Arg Met Met Arg 
65                  70                  75                  80  


Thr Leu Ile Glu Tyr Gly Phe Phe Pro Ala Glu Glu Ala Gln Arg Lys 
                85                  90                  95      


Ala Leu Glu Thr Leu Asn Pro Tyr Lys Leu Arg Ala Asp Gly Leu Asp 
            100                 105                 110         


Lys Ala Leu Thr Pro Ala Glu Phe Gly Arg Val Leu Phe His Ile Asn 
        115                 120                 125             


Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Lys Lys Asp Thr 
    130                 135                 140                 


Asp Ser Gly Ala Leu Lys Thr Ala Ile Ser Lys Leu Arg Glu Ile Leu 
145                 150                 155                 160 


Lys Thr Glu Asn Cys Arg Thr Val Gly Glu Trp Leu His Lys Arg Asn 
                165                 170                 175     


Gln Ala Gly Gln Thr Val Arg Ala Arg Tyr Arg Gln Asp Lys Thr Ile 
            180                 185                 190         


Lys Asp Asp Gly Lys Ala Lys Ile Asp Lys Tyr Tyr Asp Leu Tyr Ile 
        195                 200                 205             


Asp Arg Ala Met Ile Glu His Glu Phe Asn Glu Leu Trp Arg Lys Gln 
    210                 215                 220                 


Ala Glu Phe Asn Pro Ala Leu Phe Ser Ser Ala Ala Tyr Thr Asp Leu 
225                 230                 235                 240 


Lys Asp Val Leu Leu Tyr Gln Arg Pro Leu Lys Pro Val Lys Pro Gly 
                245                 250                 255     


Arg Cys Thr Phe Met Ser Asp Glu Glu Arg Ala Pro Leu Ala Leu Pro 
            260                 265                 270         


Ser Thr Gln Arg Phe Arg Met Tyr Gln Glu Val Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Arg Glu Gly Leu Lys Glu Glu Pro Leu Thr Leu Gln Gln Arg Asp 
    290                 295                 300                 


Asp Leu Ile Val Val Leu Glu Arg Asn Asn Lys Arg Thr Phe Thr Gln 
305                 310                 315                 320 


Ile Lys Lys Leu Leu Gly Val Gly Gly Ala Val Gln Phe Asn Phe Glu 
                325                 330                 335     


Asp Pro Lys Arg Glu Glu Leu Lys Gly Asn Thr Thr Asn Ala Ile Leu 
            340                 345                 350         


Gly Lys Lys Glu His Phe Gly Glu Ala Trp Ile Ala Phe Asp Glu Ala 
        355                 360                 365             


Lys Gln Asp Ala Ile Val Met Gln Leu Ile Lys Glu Glu Asn Glu Ala 
    370                 375                 380                 


Lys Leu Ile Gln Trp Leu Gln Asp Glu Thr Gly Ile Glu Glu Glu Arg 
385                 390                 395                 400 


Ala Glu Ile Ile Ala Asn Val Gly Leu Pro Glu Gly Tyr Gly Ser Leu 
                405                 410                 415     


Gly Thr Lys Ala Leu Ala Arg Ile Leu Pro Glu Leu Arg Arg Asp Val 
            420                 425                 430         


Val Thr Tyr Asp Lys Ala Val Gln Ala Ala Gly Phe Glu His His Ser 
        435                 440                 445             


Lys Leu Asn Gln Asn Arg Gly Ile Pro Gly Ile Thr Phe Lys Ile Glu 
    450                 455                 460                 


Ser Ile Asp Gln Asp Thr Gly Glu Ile Lys Glu Phe His Ile His Lys 
465                 470                 475                 480 


Glu Leu Pro Tyr Tyr Gly Glu Tyr Leu Gln Arg His Val Gly Phe Gly 
                485                 490                 495     


Ser Gly Lys Pro Glu Asp Pro Ile Glu Lys Arg Tyr Gly Lys Ile Ala 
            500                 505                 510         


Asn Pro Thr Val His Ile Gly Leu Asn Gln Val Arg Leu Ala Val Asn 
        515                 520                 525             


Ala Leu Ile Lys Arg Tyr Gly His Pro Ser Glu Val Ile Val Glu Val 
    530                 535                 540                 


Ala Arg Asp Leu Lys Gln Ser Lys Glu Gln Arg Ser Glu Glu Asn Lys 
545                 550                 555                 560 


Arg Gln Ala Glu Asn Gln Gln Arg Asn Asn Arg Leu Arg Thr Glu Ile 
                565                 570                 575     


Ala Arg Ile Leu Gln Ile Asn Glu Glu Gly Ile Arg Arg Asp Asp Ile 
            580                 585                 590         


Glu Lys Met Ile Leu Trp Ile Glu Leu Ser Ala Asp Val Ala Asp Arg 
        595                 600                 605             


Lys Cys Pro Tyr Ser Gly Val Pro Ile Ser Ala Thr Met Leu Leu Ser 
    610                 615                 620                 


Asp Glu Val Glu Ile Glu His Ile Leu Pro Phe Ser Gln Thr Leu Asp 
625                 630                 635                 640 


Asp Ser Leu Asn Asn Lys Thr Val Ala Leu Arg Lys Ala Asn Arg Val 
                645                 650                 655     


Lys Gly Asp Arg Thr Pro Trp Glu Ala Gln Gln Asp Phe Ala Ala Gln 
            660                 665                 670         


Gly Trp Ser Tyr Ala Asp Ile Leu Ala Arg Ala Glu Asn Met Arg Lys 
        675                 680                 685             


Glu Lys Arg Tyr Arg Phe Ala Glu Asp Gly Tyr Lys Arg Trp Leu Lys 
    690                 695                 700                 


Asp Asp Ala Gly Phe Leu Pro Arg Ala Leu Asn Asp Thr Arg Tyr Leu 
705                 710                 715                 720 


Ser Arg Val Ala Arg Glu Tyr Leu His Leu Ile Cys Pro Asn Thr Arg 
                725                 730                 735     


Val Ile Pro Gly Arg Ile Thr Ala Met Leu Arg Ser Gln Phe Gly Leu 
            740                 745                 750         


Asn Lys Val Leu Gly Leu Asn Gly Glu Lys Asn Arg Asn Asp His Arg 
        755                 760                 765             


His His Ala Val Asp Ala Cys Val Ile Gly Val Thr Asp Gln Gly Leu 
    770                 775                 780                 


Leu Gln Lys Phe Ala Lys Ala Ser Ala Ser Ala Arg Glu Lys Gln Leu 
785                 790                 795                 800 


Asn Arg Leu Val Asp Asn Met Glu Ser Pro Trp Lys Asn Tyr Gln Glu 
                805                 810                 815     


His Val Gln Arg Ala Ile Asp Ala Ile Trp Val Ser His Lys Pro Asp 
            820                 825                 830         


His Ser His Glu Gly Ala Met His Asn Asp Thr Ala Tyr Gly Leu Arg 
        835                 840                 845             


Gly Asn Gly Lys Val Ser Phe His Lys Met Met Asp Gly Lys Arg Glu 
    850                 855                 860                 


Tyr Ile Glu Asp Asn Leu Lys Val Ile Glu Ile Ala Asp Thr Lys Ala 
865                 870                 875                 880 


Ala Glu Arg His Gly Leu Leu Pro Asn Gly Lys Pro Lys Pro Tyr Lys 
                885                 890                 895     


Gly Tyr Lys Gly Asp Ser Asn Tyr Cys Ile Glu Ile Val Arg Asn Glu 
            900                 905                 910         


Lys Gly Arg Trp Glu Gly Glu Val Ile Ser Thr Phe Glu Ala Tyr Gln 
        915                 920                 925             


Leu Val Arg Glu Gln Gly Ala Ala Gln Leu Arg His Pro Ala Leu Gly 
    930                 935                 940                 


Ile Ser Gly Lys Pro Leu Val Met Arg Leu Met Ile Asp Asp Thr Val 
945                 950                 955                 960 


Arg Leu Asp Val Asp Gly Gln Ser Cys Thr Met Arg Ile Ala Lys Leu 
                965                 970                 975     


Ser Ser Asn Gly Gln Ile Phe Met Ala Asp Ile Cys Glu Ala Asn Val 
            980                 985                 990         


Asp Ala Arg Asn Arg Asn Lys Glu  Asp Ser Phe Ala Tyr  Ile Ser Lys 
        995                 1000                 1005             


Met Ala  Gly Ser Leu Gln Thr  Ala Lys Ala Arg Arg  Val Thr Ile 
    1010                 1015                 1020             


Ser Pro  Ile Gly Glu Leu Arg  Asp Ser Gly Phe Lys  Gly 
    1025                 1030                 1035     


<210>  5
<211>  1062
<212>  PRT
<213>  Novosphingobium sp. SYSU G00007

<400>  5

Met Glu Lys Arg Leu Gly Leu Asp Ile Gly Thr Asn Ser Ile Gly Trp 
1               5                   10                  15      


Cys Leu Tyr Glu Gly Asp Ser Ile Leu Asp Ile Gly Val Arg Ile Phe 
            20                  25                  30          


Ser Asp Gly Arg Asp Pro Lys Ser Gly Ala Ser Leu Ala Val Asp Arg 
        35                  40                  45              


Arg Asn Ala Arg Ala Met Arg Arg Arg Arg Asp Arg Tyr Leu Gly Arg 
    50                  55                  60                  


Arg Ser Ala Leu Ile Lys Ala Leu Lys Ala His Gly Leu Phe Pro Ala 
65                  70                  75                  80  


Glu Gln Asp Ala Ala Lys Ala Leu Glu Arg Glu Asp Pro Tyr Ser Leu 
                85                  90                  95      


Arg Val Arg Ala Leu Asp His Arg Leu Asp Pro His Gln Ile Gly Arg 
            100                 105                 110         


Ala Ile Phe His Leu Asn Gln Arg Arg Gly Phe Arg Ser Asn Arg Lys 
        115                 120                 125             


Ala Asp Arg Val Leu Gly Asp Gln Glu Ser Gly Leu Ile Ser Thr Ala 
    130                 135                 140                 


Thr Arg Val Leu Asp Glu Ala Met Ala Lys Ser Gly Ala Arg Thr Leu 
145                 150                 155                 160 


Gly Glu Phe Leu Ala Ser Arg Asp Thr Arg Arg Val Arg Met Arg Pro 
                165                 170                 175     


Asp Val Lys Gly Tyr Asp Phe Tyr Pro Asn Arg Gln His Tyr Leu Glu 
            180                 185                 190         


Glu Phe Glu Lys Ile Trp Asp Ala Gln Ser Gln Tyr His Pro Asp Leu 
        195                 200                 205             


Leu Ser Gln Gln Ala Lys Ser Ala Ile His Arg Ile Ile Phe His Gln 
    210                 215                 220                 


Arg Pro Leu Lys Pro Gln Ala Val Gly Thr Cys Thr Phe Ala Gly Leu 
225                 230                 235                 240 


His Gly Ile Pro Gly Asp Glu Thr Arg Leu Pro Lys Ala His Pro Leu 
                245                 250                 255     


Phe Gln Gln Arg Arg Leu Tyr Glu Glu Val Asn Gln Leu Glu Ile Val 
            260                 265                 270         


Cys Ala Ser Ala Pro Ala Arg Lys Leu Thr Arg Asp Glu Arg Asp Ala 
        275                 280                 285             


Leu Ile Leu Lys Leu Gln Asp Lys Lys Lys Val Thr Phe Ser Thr Leu 
    290                 295                 300                 


Ala Arg Thr Ile Arg Leu Lys Glu Gly Glu Arg Phe Asn Lys Glu Ser 
305                 310                 315                 320 


Glu Asn Arg Lys Asp Leu Ala Gly Asp Glu Val Arg Ala Glu Met Ser 
                325                 330                 335     


Asp Lys Thr Arg Phe Gly Arg Arg Trp Phe His Leu Ser Leu Asp Glu 
            340                 345                 350         


Gln Trp Ser Val Ile Asp Arg Leu Leu Asn Glu Glu Ser Thr Glu Asp 
        355                 360                 365             


Leu Leu Ala Trp Leu Glu Lys Glu Trp Ser Leu Pro Ser Asp Val Ala 
    370                 375                 380                 


Glu Ala Val Ala Asn Ala His Leu Pro Asp Gly His Gly Arg Phe Gly 
385                 390                 395                 400 


Leu Thr Ala Thr Val Arg Leu Leu Glu His Leu Lys Ala Asp Val Val 
                405                 410                 415     


Thr Tyr Ala Glu Ala Ala Arg Arg Ala Gly Phe His His Ser Asp Phe 
            420                 425                 430         


Arg Asp Gly Ala Cys Tyr Asp Glu Leu Pro Tyr Tyr Gly Glu Ile Leu 
        435                 440                 445             


Ser Arg Glu Ile Ala Pro Gly Lys Asp Glu Tyr Gly Asp Pro Leu Glu 
    450                 455                 460                 


Arg Gln Trp Gly Lys Ile Thr Asn Pro Thr Val His Ile Gly Leu Asn 
465                 470                 475                 480 


Gln Leu Arg Arg Leu Ile Asn Ala Leu Val Arg Arg His Gly Arg Pro 
                485                 490                 495     


Asp Phe Ile Phe Val Glu Leu Ala Arg Glu Leu Lys Leu Asn Glu Lys 
            500                 505                 510         


Gln Lys Ala Asp His Lys Arg Arg Ile Lys Gln Thr Thr Asp Ala Ala 
        515                 520                 525             


Arg Ala Arg Ala Glu Lys Leu Arg Glu Ile Gly Gln Arg Asp Ser Gly 
    530                 535                 540                 


Ser Asn Arg Met Leu Leu Arg Ile Trp Glu Glu Leu Asn Pro Ser Asn 
545                 550                 555                 560 


Pro Leu Asp Arg Arg Cys Pro Tyr Cys Ala Glu Pro Ile Ser Ile Glu 
                565                 570                 575     


Met Leu Met Ser Gly Ser Ala Asp Ile Asp His Ile Val Pro Tyr Ser 
            580                 585                 590         


Arg Cys Leu Asp Asp Ser Ala Ala Asn Lys Val Val Ala His Asn His 
        595                 600                 605             


Cys Asn Arg Gln Lys Gly Asn Arg Thr Pro Trp Glu Gln Trp Gly Gln 
    610                 615                 620                 


Thr Thr Arg Trp Pro Leu Ile Gln Glu Gln Val Ala Arg Met His Arg 
625                 630                 635                 640 


Ser Lys Gln Trp Arg Phe Gly Pro Asp Ala Met Glu Arg Val Asp Arg 
                645                 650                 655     


Asp Gly Gly Phe Ile Ala Arg Gln Leu Thr Asp Thr Gln Tyr Leu Ser 
            660                 665                 670         


Arg Ile Ala Ala Gln Tyr Leu Ser Ala Leu Tyr Thr Pro Asp Glu Gly 
        675                 680                 685             


Arg Arg Val Tyr Ala Val Thr Gly Arg Leu Thr Ala Met Leu Arg Arg 
    690                 695                 700                 


Leu Trp Gly Leu Asn Asp Ile Leu Pro Asp His Asn Trp Val Leu Asn 
705                 710                 715                 720 


Pro His Ser Asn Ala Pro Lys Asn Arg Leu Asp His Arg His His Ala 
                725                 730                 735     


Ile Asp Ala Ala Val Val Gly Ala Thr Thr Pro Ala Met Ile Gln Gln 
            740                 745                 750         


Val Ala Arg Ala Ala Ala Arg Ala Glu Glu Gln Asp Leu Asp Arg Leu 
        755                 760                 765             


Phe Ala Asp Leu Pro Pro Pro Trp Pro Gly Phe Arg Glu Glu Leu Gln 
    770                 775                 780                 


Gly Arg Ile Met Ala Ala Val Val Ser His Lys Pro Asp His Gly Arg 
785                 790                 795                 800 


Lys Gly Arg Pro Leu Pro Gly Arg Asp Ser Thr Ser Gly Arg Leu His 
                805                 810                 815     


Asn Asp Thr Ala Tyr Gly Phe Thr Gly Arg Arg Asn Ala Lys Gly Met 
            820                 825                 830         


Pro Ile Val Val Thr Arg Lys Pro Leu Leu Ala Leu Lys Pro Glu Asp 
        835                 840                 845             


Leu Thr Asp Pro Glu Arg Ile Pro Asp Pro Ala Leu Gln Gly Ala Leu 
    850                 855                 860                 


Phe Glu Ala Thr Arg Gly Ala Thr Gly Lys Asp Phe Glu Lys Ala Leu 
865                 870                 875                 880 


Arg Asp Phe Ser Arg Arg Asp Gly Pro Tyr Gln Gly Ile Arg Arg Ile 
                885                 890                 895     


Arg Leu Thr Glu Ala Leu Asn Val Ile Pro Ile Arg Asp Arg Thr Gly 
            900                 905                 910         


His Ala Tyr Lys Gly Val Lys Gly Asp Ala Asn Ala Arg Phe Asp Val 
        915                 920                 925             


Trp Arg Leu Pro Asp Gly Lys Trp Ile Thr Arg Trp Lys Asp Arg Asp 
    930                 935                 940                 


Gly Ile Glu His Ser Gly Ile Val Ser Leu Phe Asp Ala His Gln Pro 
945                 950                 955                 960 


Ser Gln Val Tyr His Arg Pro His Pro Ala Ala Lys Lys Val Leu Ser 
                965                 970                 975     


Leu Arg Gln Asn Asp Leu Val Ala Val Glu His Asp Gly Asp Pro Gly 
            980                 985                 990         


Lys Ile Met Arg Val Val Lys Phe  Ser Ala Asn Gly Ser  Ile Thr Phe 
        995                 1000                 1005             


Ala Pro  His Asn Glu Ala Gly  Pro Leu Lys Thr Arg  Asp Thr Asp 
    1010                 1015                 1020             


Pro Ala  Asp Pro Phe Arg Tyr  Val Thr Thr Val Ala  Ser Gly Leu 
    1025                 1030                 1035             


Lys Lys  Met Arg Ala Arg Gln  Val Arg Ile Asp Glu  Leu Gly Lys 
    1040                 1045                 1050             


Val His  Asp Pro Gly Pro Arg  Glu Asp 
    1055                 1060         


<210>  6
<211>  1075
<212>  PRT
<213>  Paracoccus bengalensis

<400>  6

Met Thr Thr Thr Leu Gly Ile Asp Leu Gly Thr Ser Ser Leu Gly Trp 
1               5                   10                  15      


Cys Leu Ile Glu Asp Glu His Arg Ile Leu Asp Leu Gly Val Ile Ile 
            20                  25                  30          


Phe Ser Ala Ala Ala Gly Ala Gly Arg Asp Pro Gln Ser Gly Ala Pro 
        35                  40                  45              


Leu Ala Glu Ala Arg Arg Glu Ala Arg Ser Ala Arg Arg Arg Arg Asp 
    50                  55                  60                  


Arg Phe Ile Gly Arg Arg Ser Ala Leu Leu Asp Lys Leu Ile Ala Leu 
65                  70                  75                  80  


Gly Leu Leu Pro Gly Asp Pro Pro Ala Gly His Gly Arg Arg Arg Asn 
                85                  90                  95      


Gln Ala Leu Pro Asn Ala Glu Thr Lys Ala Leu Ala Asp Thr Asp Pro 
            100                 105                 110         


His Val Leu Arg Arg Arg Ala Leu Ser Glu Pro Leu Ser Pro His Glu 
        115                 120                 125             


Ile Gly Arg Ala Ile Phe His Leu Asn Thr Arg Arg Gly Phe Lys Ser 
    130                 135                 140                 


Asn Arg Lys Ala Asp Arg Gly Arg Asn Glu Pro Glu Thr Gly Lys Ile 
145                 150                 155                 160 


Ala Thr Ala Gly Gln Ala Leu Asp Ala Ala Leu Gly Lys Arg Thr Leu 
                165                 170                 175     


Gly Gln Phe Leu Ala Asp Arg Ile Asp Ala Gly Gln Pro Ala Arg Val 
            180                 185                 190         


Arg Met Gly Gly Glu Asn Gln Ala Tyr Asp Phe Tyr Pro Gln Arg Ser 
        195                 200                 205             


His Leu Glu Ala Glu Phe Ala Ala Ile Trp Glu Ala Gln Glu His His 
    210                 215                 220                 


His Pro Glu Leu Leu Thr Asp Thr Ala Arg Thr Ala Ile His Arg Ile 
225                 230                 235                 240 


Leu Phe Phe Gln Arg Pro Leu Lys Thr Pro Glu Val Gly Phe Cys Thr 
                245                 250                 255     


Phe Ala Gly Met Ser Gly Val Pro His Asp Glu Arg Arg Leu Pro Lys 
            260                 265                 270         


Ala His Pro Leu Phe Gln Glu Arg Arg Leu Tyr Glu Glu Val Asn Asn 
        275                 280                 285             


Leu Lys Val Val Ala Ala Gly Ala Ala Ala Arg Asp Leu Thr Leu Asp 
    290                 295                 300                 


Glu Arg Asp Arg Leu Ile Leu Lys Leu Arg Asp Asn Lys Lys Val Thr 
305                 310                 315                 320 


Phe Ala Thr Leu Ala Lys Lys Val Leu Lys Leu Ala Glu Gly Glu Arg 
                325                 330                 335     


Phe Asn Lys Glu Ser Glu Ala Arg Lys Asp Leu Ala Gly Asp Glu Val 
            340                 345                 350         


Arg Ala Glu Met Ala Asp Lys Lys Arg Phe Gly Asn Arg Trp Thr His 
        355                 360                 365             


Phe Pro Leu Glu Arg Gln Leu Gln Ile Ile Asp Arg Val Gln Asn Glu 
    370                 375                 380                 


Glu Asn Pro Asp Ile Leu Leu Ala Trp Leu Gln Ser Asp Cys Gly Leu 
385                 390                 395                 400 


Asp Lys Ala Ala Ala Val Ala Val Ala Arg Thr Asn Leu Pro Glu Gly 
                405                 410                 415     


His Gly Arg Phe Gly Glu Thr Ala Thr Arg Arg Leu Ile Ala Ala Leu 
            420                 425                 430         


Lys Ala Glu Val Val Thr Tyr Asp Lys Ala Ala Leu Ala Ala Gly Phe 
        435                 440                 445             


His His Ser Asp His Arg Thr Gly Glu Val Tyr Asp Leu Leu Pro Tyr 
    450                 455                 460                 


Tyr Gly Glu Val Leu Thr Arg Glu Ile Ala Pro Gly Lys Ala Glu Tyr 
465                 470                 475                 480 


Gly Asp Pro Leu Glu Arg Gln Tyr Gly Lys Val Thr Asn Pro Thr Val 
                485                 490                 495     


His Ile Gly Leu Arg Gln Leu Gln Lys Leu Val Asn Ala Val Ile Ala 
            500                 505                 510         


Arg His Gly Arg Pro Asp Arg Ile Val Ile Glu Leu Ala Arg Glu Leu 
        515                 520                 525             


Lys Leu Asn Asp Lys Gln Lys Asp Glu His Gln Arg Arg Ile Arg Arg 
    530                 535                 540                 


Asp Thr Glu Ala Ala Ile Arg Arg Gly Glu Lys Leu Val Glu Ala Gly 
545                 550                 555                 560 


Ile Ala Asp Thr Gly Ala Asn Arg Ala Leu Met Arg Gln Trp Glu Glu 
                565                 570                 575     


Leu Asn Pro Ser Asn Pro Leu Asp Arg Arg Cys Pro Tyr Cys Gly Glu 
            580                 585                 590         


Pro Ile Gly Met Ala Gln Ile Phe Asn Ser Leu Ala Asp Ile Asp His 
        595                 600                 605             


Ile Ile Pro Tyr Ser Arg Ser Leu Asp Asp Ser Pro Ala Asn Lys Val 
    610                 615                 620                 


Leu Val His Arg Asn Cys Asn Arg Gln Lys Gly Asn Lys Thr Pro Trp 
625                 630                 635                 640 


Asp Arg Trp His Glu Asp Glu Ala Lys Trp Glu Ile Ile Ser Ala Gln 
                645                 650                 655     


Val Ala Arg Met His Pro Ser Lys Gln Trp Arg Phe Gly Pro Asp Ala 
            660                 665                 670         


Met Glu Arg Leu Glu Arg Asp Gly Gly Phe Ala Ala Arg Gln Leu Thr 
        675                 680                 685             


Asp Thr Gln Tyr Leu Ala Arg Ile Ala Asp Lys Tyr Leu Arg Gly Leu 
    690                 695                 700                 


Tyr Pro Thr Ala Asp Glu Gly Arg Val Asp Val Ile Pro Gly Arg Met 
705                 710                 715                 720 


Thr Ala Met Leu Arg Arg Val Trp Gly Leu Asn Ser Leu Leu Pro Asp 
                725                 730                 735     


His Asn Phe Val Glu Asn Glu His Ser Ser Ala Pro Lys Asn Arg Leu 
            740                 745                 750         


Asp His Arg His His Ala Ile Asp Ala Thr Val Ala Ala Val Thr Ser 
        755                 760                 765             


Leu Ser Arg Met Gln Gln Ile Ala Ala Ala Ala Ala Arg Ser Glu Glu 
    770                 775                 780                 


Lys Glu Leu Glu Arg Leu Phe Asp Asp Leu Pro His Pro Trp Asp Gly 
785                 790                 795                 800 


Phe Arg Glu Asp Leu Gly Ala Cys Leu Ala Arg Thr Val Ala Thr His 
                805                 810                 815     


Lys Pro Asp His Gly Arg Ser Ala Lys Pro Ser Arg His Arg Asp Val 
            820                 825                 830         


Thr Ala Gly Lys Leu His Asn Asp Thr Ala Tyr Gly Leu Thr Gly Leu 
        835                 840                 845             


Lys Thr Thr Asp Gly Lys Thr Pro Ile Val Val His Arg Val Leu Leu 
    850                 855                 860                 


Ala Ser Leu Lys Pro Thr Gln Ile Ala Asp Pro Asp Cys Ile Pro Asp 
865                 870                 875                 880 


Glu Thr Leu Arg Asn Ala Leu Trp Leu Ala Thr Arg Asp Cys Ser Gly 
                885                 890                 895     


Lys Ala Phe Asp Gln Ala Leu Ala Arg Phe Ala Lys Glu His Pro Val 
            900                 905                 910         


Phe Lys Gly Ile Arg Arg Val Arg Ile Arg Glu Pro Leu Asn Val Ile 
        915                 920                 925             


Pro Ile His Asp Arg Glu Gly Lys Pro Tyr Lys Ser Tyr Ala Gly Ala 
    930                 935                 940                 


Ser Asn Asp Arg Tyr Asn Val Trp Arg Met Pro Asp Ala Ser Trp Arg 
945                 950                 955                 960 


His Asp Val Val Ser Thr Phe Asn Ala His Arg Ser Asp Tyr Arg Asp 
                965                 970                 975     


Leu Arg Pro His Pro Ala Ala Lys Lys Val Leu Ser Leu Arg Gln Asn 
            980                 985                 990         


Asp Met Ile Ala Val Glu Arg Asn  Gly Gly Leu Arg Glu  Ile Met Arg 
        995                 1000                 1005             


Val Val  Lys Phe Asn Gln Ala  Gly Arg Leu Thr Leu  Cys Pro Pro 
    1010                 1015                 1020             


Asn Glu  Gly Gly Lys Leu Gln  Asn Arg Asp Ala Ala  Pro Asn Asp 
    1025                 1030                 1035             


Ala Asp  Pro Phe Lys Tyr Thr  Tyr Leu Ser Pro Ser  Ser Leu Lys 
    1040                 1045                 1050             


Asn Ala  Lys Ala Arg Gln Val  Arg Ile Asp Pro Leu  Gly Arg Val 
    1055                 1060                 1065             


Phe Asp  Pro Gly Pro Arg Glu  
    1070                 1075 


<210>  7
<211>  1045
<212>  PRT
<213>  Parvibium lacunae

<400>  7

Met Lys Asn Lys Met Gln Tyr Arg Leu Ala Leu Asp Leu Gly Thr Thr 
1               5                   10                  15      


Ser Leu Gly Trp Ala Met Leu Arg Val Lys Pro Asn Pro Glu Gly Arg 
            20                  25                  30          


Leu Glu Pro Phe Ala Val Val Lys Ala Gly Val Arg Ile Phe Ser Asp 
        35                  40                  45              


Gly Arg Asn Pro Lys Asp Gly Ser Ser Leu Ala Val Thr Arg Arg Glu 
    50                  55                  60                  


Ala Arg Ala Met Arg Arg Arg Arg Asp Arg Leu Leu Lys Arg Lys Ala 
65                  70                  75                  80  


Arg Met Leu Gln Gln Leu Thr Ala Phe Gly Phe Phe Pro Thr Asp Leu 
                85                  90                  95      


Ala Glu Arg Lys Ala Leu Glu Thr Leu Asn Pro Tyr Glu Leu Arg Ala 
            100                 105                 110         


Lys Gly Leu Asp Glu Pro Leu Ser Pro Tyr Glu Phe Gly Arg Ser Leu 
        115                 120                 125             


Phe His Ile Asn Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp 
    130                 135                 140                 


Lys Lys Glu Asn Asp Ser Ser Ala Leu Lys Ala Ala Ile Arg Arg Val 
145                 150                 155                 160 


Ala Ser Glu Ile Asp Gly Asn Gln Ala Arg Thr Val Gly Glu Trp Leu 
                165                 170                 175     


Tyr Lys Arg Met Leu Asn Gly Gln Pro Val Arg Gly Arg Tyr Arg Glu 
            180                 185                 190         


Thr Lys Val Gln Lys Glu Asp Gly Lys Thr Lys Ile Asp Lys Ser Tyr 
        195                 200                 205             


Asp Leu Tyr Ile Asp Arg Ala Met Val Glu Ala Glu Phe Glu Ala Leu 
    210                 215                 220                 


Trp Ala Lys Gln Ala Ser Leu Asn Pro Ala Val Tyr Ser Glu Gln Ala 
225                 230                 235                 240 


Lys Ala Thr Leu Lys Asp Val Leu Leu Phe Gln Arg Asn Leu Arg Pro 
                245                 250                 255     


Val Lys Pro Gly Arg Cys Thr Leu Ile Pro Thr Glu Glu Arg Ala Pro 
            260                 265                 270         


Leu Ala Leu Pro Ser Thr Gln Arg Phe Arg Ile Tyr Gln Glu Val Asn 
        275                 280                 285             


Asn Leu Arg Ile Leu Arg Glu Gly Leu Lys Asp Glu Ala Leu Thr Leu 
    290                 295                 300                 


Val Gln Arg Asp Ala Leu Val Thr Ala Leu Glu Gln Asn Asn Lys Arg 
305                 310                 315                 320 


Thr Phe Ala Gln Ile Lys Lys Leu Leu Gly Leu Asp Gly Gln Thr Gln 
                325                 330                 335     


Phe Asn Phe Glu Asp Pro Lys Arg Gln Glu Leu Lys Gly Asn Thr Thr 
            340                 345                 350         


Ser Ala Ile Leu Ser His Pro Lys His Phe Gly Asp Ala Trp Phe Gly 
        355                 360                 365             


Phe Asp Glu Ala Lys Gln Asp Gly Ile Val Cys Gln Leu Leu Asn Glu 
    370                 375                 380                 


Glu Asn Glu Ser Ala Leu Ile Arg Trp Leu Met Asp His Thr Gly Val 
385                 390                 395                 400 


Asp Glu Ala His Ala Glu Ala Ile Ala Asn Ala Ala Leu Pro Glu Gly 
                405                 410                 415     


Tyr Gly Ser Leu Ser Arg Ala Ala Leu Ala Lys Ile Leu Pro Glu Leu 
            420                 425                 430         


Arg Lys Ala Val Ile Thr Tyr Asp Lys Ala Ala Gln Ala Ala Gly Phe 
        435                 440                 445             


Asp His His Ser His Ile Ser Pro Ser Thr Thr Gly Glu Ile Leu Pro 
    450                 455                 460                 


Glu Leu Pro Tyr Tyr Gly Glu Ala Leu Gln Arg His Val Gly Phe Gly 
465                 470                 475                 480 


Thr Gly Asn Pro Asp Asp Val Pro Glu Lys Arg Tyr Gly Lys Ile Ala 
                485                 490                 495     


Asn Pro Thr Val His Ile Gly Leu Asn Gln Val Arg Lys Val Val Asn 
            500                 505                 510         


Ala Leu Ile Lys Arg Tyr Gly His Pro Ser Glu Val Ile Val Glu Val 
        515                 520                 525             


Ala Arg Asp Leu Lys Gln Ser Lys Lys Gln Arg Asp Glu Glu Asn Lys 
    530                 535                 540                 


Arg Gln Ala Glu Asn Gln Lys Arg Asn Glu Arg Ile Arg Gln Asp Ile 
545                 550                 555                 560 


Ala Ala Met Arg Pro Asp Arg Ser Glu Glu Arg Val Thr Arg Thr Asp 
                565                 570                 575     


Ile Gln Lys Trp Ile Leu Trp Glu Glu Leu Ser Phe Asp Pro Ala Asn 
            580                 585                 590         


Arg Cys Cys Pro Tyr Ser Gly Val Gln Ile Ser Ala Glu Met Leu Met 
        595                 600                 605             


Ser Asp Ala Val Glu Ile Glu His Ile Leu Pro Phe Ser Arg Thr Leu 
    610                 615                 620                 


Asp Asp Ser Leu Asn Asn Lys Thr Val Ser Met Arg Gln Ala Asn Arg 
625                 630                 635                 640 


Ile Lys Gly Asn Gln Thr Pro Phe Glu Ala Phe Gly Lys Asp Asn Ala 
                645                 650                 655     


Leu Gly Val Asn Tyr Ser Asp Ile Leu Met Arg Ala Gln Gln Met Pro 
            660                 665                 670         


Lys Ala Lys Arg Lys Arg Phe Ala Glu Asn Ala Leu Glu Glu Trp Leu 
        675                 680                 685             


Gln Asn Glu Lys Asn Phe Leu Ala Arg Ala Leu Asn Asp Thr Arg Tyr 
    690                 695                 700                 


Leu Ser Arg Val Ala Arg Glu Tyr Val Ser Leu Ile Cys Pro Gln Ala 
705                 710                 715                 720 


Thr Arg Val Ile Pro Gly Gln Met Thr Ala Gln Leu Arg Ala Lys Phe 
                725                 730                 735     


Gly Leu Asn Asp Ile Leu Gly Leu Asp Gly Glu Lys Asn Arg Asn Asp 
            740                 745                 750         


His Arg His His Ala Val Asp Ala Cys Val Ile Gly Val Thr Asp Gln 
        755                 760                 765             


Gly Leu Leu Gln Arg Phe Ala Tyr Ala Ser Ala Ser Ala Arg Ala Asn 
    770                 775                 780                 


Gly Leu Ala Arg Leu Val Asp Thr Met Pro Asp Pro Trp Pro Ser Tyr 
785                 790                 795                 800 


Arg Gln His Val Gln Arg Ala Val Gln Asn Ile Tyr Val Ser His Lys 
                805                 810                 815     


Pro Asp His Ser His Glu Gly Ala Met Phe Asp Glu Thr Ile Tyr Ser 
            820                 825                 830         


Ala Thr Gly Lys Ser Arg Ser Ala Ala Lys Asp Arg Thr Val Ile Pro 
        835                 840                 845             


Phe Ile Ala Lys Asn Trp Ser His Pro Asp Asp His Asn Lys Gln Arg 
    850                 855                 860                 


Pro Phe Lys Gly Leu Ile Thr Asp Val Ser Gln Arg His Gln Asn Lys 
865                 870                 875                 880 


Pro Tyr Lys Gly Leu Leu Ser Asn Ser Asn Tyr Cys Ile Glu Ile Tyr 
                885                 890                 895     


Ser Asp Glu Ala Gly Trp Gly Gly His Val Leu Lys Thr Phe Asp Ala 
            900                 905                 910         


Tyr Gln Ile Val Arg Ala His Lys Asn Ala Ser Glu Gly Met Gln Ala 
        915                 920                 925             


Leu Arg Asn Lys His Ser Ser Gln Asn Gly His Pro Leu Val Met Arg 
    930                 935                 940                 


Leu Met Ile Gly Asp Tyr Ile Arg Ala Glu Ile Asp Gly Phe Leu Leu 
945                 950                 955                 960 


Leu Leu Gln Val Leu Lys Ile Asn Ser Ser Gly Ser Ile Thr Phe Ile 
                965                 970                 975     


Lys Pro Asn Glu Thr Asn Ile Ser Ala Arg Tyr Leu Ala Lys Leu Ala 
            980                 985                 990         


Ala Gln Lys Ala Gln Lys Glu Gly  Lys Pro Phe Asp Asp  Ile Ala Leu 
        995                 1000                 1005             


Asn Asp  Val Phe Phe Gln Lys  Ala Ile Ser Ala Asp  Ser Leu Arg 
    1010                 1015                 1020             


Leu Phe  Lys Ala Arg Pro Val  Thr Leu Ser Pro Ile  Gly Glu Leu 
    1025                 1030                 1035             


Arg Asp  Pro Gly Phe Lys Gly  
    1040                 1045 


<210>  8
<211>  1071
<212>  PRT
<213>  Pelagicola sp. LXJ1103

<400>  8

Met Arg Leu Gly Leu Asp Ile Gly Thr Asn Ser Ile Gly Trp Trp Leu 
1               5                   10                  15      


Tyr Arg Thr Glu Asn Asp Gln Ile Thr Cys Val Val Asp Gly Gly Val 
            20                  25                  30          


Arg Val Phe Ser Asp Gly Arg Asp Pro Gln Ser Lys Glu Ser Leu Ala 
        35                  40                  45              


Val Asp Arg Arg Val Ala Arg Ala Gln Arg Arg Arg Arg Asp Arg Tyr 
    50                  55                  60                  


Leu Arg Arg Lys Ala Ala Leu Met Lys Arg Met Ala Glu Ala Gly Leu 
65                  70                  75                  80  


Met Pro Ala Asp Pro Val Gln Ala Lys Ala Leu Gln Ala Leu Asp Pro 
                85                  90                  95      


Tyr Asp Leu Arg Ala Arg Gly Leu Asp Glu Ala Leu Pro Leu Ala His 
            100                 105                 110         


Phe Gly Arg Ala Leu Phe His Leu Asn Gln Arg Arg Gly Phe Lys Ser 
        115                 120                 125             


Asn Arg Lys Ala Asp Arg Gly Asp Asn Glu Ser Gly Lys Ile Lys Asp 
    130                 135                 140                 


Ala Thr Ala Arg Leu Asp Trp Ala Met Arg Asp Ala Arg Ala Arg Thr 
145                 150                 155                 160 


Tyr Gly Glu Phe Leu His Met Arg Gln Asp Lys Ala Asp Asp Pro Arg 
                165                 170                 175     


Arg Val Pro Thr Val Arg Thr Arg Leu Ser Val Ala Arg Arg Asp Asn 
            180                 185                 190         


Ala Glu Lys Glu Glu Ala Gly Tyr Asp Phe Tyr Pro Asp Arg Arg His 
        195                 200                 205             


Leu Ser Glu Glu Phe Asp Ala Leu Trp Ala Ala Gln Ala Glu His His 
    210                 215                 220                 


Thr Thr Leu Thr Asp Asp Leu Arg Asp Gln Ile Lys Thr Ile Ile Phe 
225                 230                 235                 240 


His Gln Arg Pro Leu Lys Ala Pro Glu Val Gly Leu Cys Leu Phe Thr 
                245                 250                 255     


Asp Glu Arg Arg Ile Pro Ser Ala His Pro Leu Asn Gln Arg Arg Ile 
            260                 265                 270         


Leu Leu Glu Thr Val Asn Gly Leu Arg Ile Val Ala Arg Gly Glu Ala 
        275                 280                 285             


Ala Arg Gly Leu Thr Arg Glu Glu Arg Asp Gln Ile Val His Gly Leu 
    290                 295                 300                 


Asp Asn Lys Gly His Thr Lys Thr Leu Ser Gly Met Ser Met Lys Leu 
305                 310                 315                 320 


Arg Ala Ile Gly Lys Val Ile Lys Leu Arg Ser Asp Gln Ser Phe Thr 
                325                 330                 335     


Leu Glu Thr Ala Asn Arg Asp Ala Ile Ala Cys Asp Pro Val Arg Ala 
            340                 345                 350         


Ser Leu Ser His Pro Glu Arg Met Gly Gly Val Trp Thr Thr Leu Asp 
        355                 360                 365             


Glu Asp Ala Gln Trp Asp Val Val Gln Arg Leu Arg Ala Val Gln Ser 
    370                 375                 380                 


Asp Thr Glu His Glu Ala Leu Val Asp Trp Leu Met Ala Thr His Gly 
385                 390                 395                 400 


Leu Gly Gln Asp Tyr Ala Gln Ala Thr Ala Asn Ala Pro Leu Pro Glu 
                405                 410                 415     


Gly Tyr Gly Arg Leu Gly Leu Thr Ala Thr Arg Lys Ile Leu Ala Ala 
            420                 425                 430         


Leu Glu Ala Asp Val Met Ser Tyr Ser Asp Ala Val Ala Ala Cys Gly 
        435                 440                 445             


Trp Ser His Ser Gly Gly Pro Thr Gly Glu Val Leu Glu Ala Leu Pro 
    450                 455                 460                 


Tyr Tyr Gly Glu Ile Leu Asp Arg His Val Ile Pro Gly Thr Gly Val 
465                 470                 475                 480 


Lys Thr Asp Glu Asp Val Lys Arg Phe Gly Arg Ile Thr Asn Pro Thr 
                485                 490                 495     


Val His Ile Gly Leu Asn Gln Ile Arg Arg Leu Val Asn Arg Ile Ile 
            500                 505                 510         


Cys Val His Gly Lys Pro Asp Gln Ile Val Val Glu Val Ala Arg Asp 
        515                 520                 525             


Leu Lys Asn Ser Glu Asp Gln Lys Arg Glu Ile Gln Lys Thr Ile Arg 
    530                 535                 540                 


Lys Asn Thr Asp Asp Ala Ile Lys Arg Gly Lys Lys Leu Val Glu Glu 
545                 550                 555                 560 


Leu Gly Gln Lys Asp Thr Gly Ala Asn Arg Leu Ile Leu Arg Leu Trp 
                565                 570                 575     


Glu Asn Leu Gly Asn Asp Val Met Thr Arg Gln Cys Pro Tyr Ser Gly 
            580                 585                 590         


Lys Arg Ile Ser Ala Ala Met Leu Phe Asp Gly Ser Cys Asp Val Asp 
        595                 600                 605             


His Ile Leu Pro Phe Ser Arg Thr Leu Asp Asp Ser Ile Trp Asn Lys 
    610                 615                 620                 


Thr Leu Cys Leu Lys Glu Glu Asn Arg Lys Lys Ala Asn Lys Thr Pro 
625                 630                 635                 640 


Trp Glu Val Trp Gly Glu Thr Asp Gln Trp Asp Val Ile Val Ala Asn 
                645                 650                 655     


Leu Lys Asn Leu Asp Arg Lys Gln Ala Trp Arg Phe Ala Pro Asp Ala 
            660                 665                 670         


Val Glu Arg Phe Glu Gly Glu Asn Asp Phe Ser Ala Arg Ala Leu Lys 
        675                 680                 685             


Asp Thr Gln Tyr Leu Ser Arg Val Ala Arg Ala Tyr Leu Asp Ala Leu 
    690                 695                 700                 


Tyr Asp Gly Ala Asp Gly Lys Ser His Val Trp Val Val Pro Gly Arg 
705                 710                 715                 720 


Leu Thr Glu Met Leu Arg Arg His Trp Gly Leu Asn Gly Ile Glu Val 
                725                 730                 735     


Leu Thr Asp Ser Asp Ala Gln Thr Val Lys Ser Lys Asn Arg Gln Asp 
            740                 745                 750         


His Arg His His Ala Ile Asp Ala Ala Val Val Ala Ala Thr Asp Arg 
        755                 760                 765             


Ser Leu Ile Gln Arg Ile Ser Lys Ile Ala Lys His Asp Glu Gln Ala 
    770                 775                 780                 


Gly Ala Glu Gln Val Ala Arg Ser Val Pro Pro Pro Trp Asp Gly Phe 
785                 790                 795                 800 


Arg Asp Asp Val Ala Gly Gln Ile Gly Arg Ile Ile Val Ser His Arg 
                805                 810                 815     


Ala Asp His Gly Arg Ile Asp Pro Thr Ala Arg Ala Gln Gly Ser Asp 
            820                 825                 830         


Thr Thr Ala Gly Gln Leu His Met Asp Thr Ala Tyr Gly Ile Val Asp 
        835                 840                 845             


Gly Gly His Val Val Ser Arg Lys Pro Leu Met Ser Leu Gly Ala Gly 
    850                 855                 860                 


Asp Ile Arg Lys Ile Arg Asp Pro Asp Leu Gln Arg His Leu Thr Arg 
865                 870                 875                 880 


Val Thr Arg Gly Leu Asp Lys Lys Glu Phe Glu Gln Ala Leu Ala Ser 
                885                 890                 895     


Phe Ala Ala Ser Arg Lys Leu Pro Asp Gln Ser Glu Asn Pro Tyr Phe 
            900                 905                 910         


Gly Leu Arg Arg Val Arg Leu Leu Asp Ala Leu Gln Asp Ser Ala Arg 
        915                 920                 925             


Val Pro Val Arg Asn Ala Thr Gly Asn Ile Tyr Lys Ala Tyr Lys Ala 
    930                 935                 940                 


Gly Ser Asn His Cys Tyr Glu Val Trp Arg Met Pro Asp Gly Lys Val 
945                 950                 955                 960 


Lys Pro Trp Ala Ile Ser Thr Phe Glu Ala His Gln Ser Gly Asp Gly 
                965                 970                 975     


Ser Lys Pro His Pro Ala Ala Lys Arg Leu Leu Arg Val Phe Lys Arg 
            980                 985                 990         


Asp Met Val Val Ile Glu Arg Lys  Gly Ile Thr Val Ile  Cys Tyr Val 
        995                 1000                 1005             


Gln Lys  Met Asp Val Ala Asn  Gly Leu Phe Leu Val  Pro His Thr 
    1010                 1015                 1020             


Glu Gly  Asn Ala Asp Ala Arg  Asn Arg Asp Lys Glu  Asp Asp Phe 
    1025                 1030                 1035             


Lys Phe  Ile Gln Met Ser Ala  Ala Ser Leu Ile Lys  Ala Arg Ile 
    1040                 1045                 1050             


Arg Arg  Val His Val Asp Glu  Met Gly Arg Met Arg  Asp Pro Gly 
    1055                 1060                 1065             


Pro Pro  Arg 
    1070     


<210>  9
<211>  3147
<212>  DNA
<213>  Comamonadaceae bacterium NML00-0135

<400>  9
atgaatgtgt ggaaagggac tggtttcgtg tcaagaaaaa gaaacatcat tcgttaccga       60

ctggctttgg atctgggctc cacctcgctg ggctgggcca tcctgcgcct gaatgctgac      120

aaccagccca ccgccatcct caaggctggc gtgcgcatct tcagcgatgg ccgaaaccca      180

aaggatggct cctctctggc cgtgacccgc cgcgccgccc gcgccatgcg ccgccgtcgc      240

gaccgcctgc tcaagcgcaa ggcgcgcatg ctggacaagc tgattgcaca tggcttcttc      300

ccacaggacg aggccgcgcg caaagcattg gaggtgctca atccctacca gttgcgcgcc      360

gagggcttgc agcgcgcact gatgccgggc gagttcgccc gcgcaatgtt tcatatcaac      420

cagcgccgcg gcttcaagag caaccgcaag accgacaaga aagacagcga cagcggcgcc      480

ctcaaaaccg ccatcagcca actgcgccag caactgcaaa acgaaaacgc ccgcacggta      540

ggcgaatggc tgtggcaacg cctgcaagcc ggccaaggca cgcgtgcccg ctaccgggaa      600

acgcgcatcg ccaccgacac aggcaagggc aagatcgaca aaagctacga cctctatatc      660

gaccgccaga tggtggccga tgagttcgat gcgctgtggg ccgtgcaggc ggccttcaac      720

cccgtactgt tcaacgagca ggcacgggcc gaactgcgcg acaccctgct gcatcaacgc      780

ccgttgcgcc cggccaagcc agggcgctgc accttgctgc cggaagaaga gcgcgccccg      840

ctggccctgc ccagcacgca gcgttttcgc atcctgcaag aggtgaatca cctgcgcatt      900

ctgcacccag acttgcgtga agaagcattg acgctggatc ggcgcaatgc catcgtggcc      960

ttgctggaga acaggggaaa agtcacgttc caggccatgc gcagaacact caacctgggt     1020

gatgccgtgc aattcaattt ggaagacgcc aagcgccgtg aactcaaggg caatgccacc     1080

acggcggcac tgtcgaaaaa ggaactgttc ggggcagcgt ggcacgactt tgacgaagcc     1140

ttgcaggacg acatcgtgct gcgcctggtc acggaagaaa gcgaagccga actggtgcaa     1200

tggctgatcg aaaacactgg cgtggatgag gcacgcgcca cggccattgc caacactggc     1260

ctgccagaag gctacggcag cctcagccgc aaggcactgg cgcgcatcgt gcctgcgctg     1320

cgcgccgagg tcatcaccta cgacaaggcg gtgcaggccg ccggctttgc ccatcacagc     1380

gatttgcgat tcagtttcga gtacgacagc gccgatgtgg agcaggtggg agagcgtatc     1440

gacaaaacca ccggcgaaat cctgcctgtg tctgccttca agcagttgcc ctactacggc     1500

aaggcgctgc aacgtcacgt ggcctttggc agtggcaacc cgcaagaccc ggaagaaaaa     1560

cgctacggca agatcgccaa ccccaccgta catatcggcc tgaaccaggt gcgccgcgtg     1620

gtcaacgatt tgatccgacg ttatggccgg ccaaccgaaa tcgtggtgga actggcgcgc     1680

gagctcaagc aaagccgtga gcaaaagctg gaggcgcaac gcaagcaagc cgacaaccaa     1740

aagcgcaatg cgcgcattcg cgcggaaatt gcgcctatct tgggcatcag cgaagagcgg     1800

gtgaagcatg cagacattca gaaatggatc ctgtgggagg agttgagctt tgacgtcgcc     1860

gaccgccgct gcccctacag cggcgtgcag atcagcgcgc gcatgctgct cagcgatgag     1920

gtggaaatcg agcacatcct gcccttctct caaacgctgg atgacagcct gaacaacaaa     1980

accgtttcca tgcggcaagc caaccgcatc aaaggcaacc gcacgccttg gcaggcgcgg     2040

caggactttg aggcgcaggg ctggccgtac gagggcatgc agcaacgcgc cgaacgcatg     2100

ccccgcgcca aacgctaccg cttcgcgccc gatggttacg aacgctggct gggtgaggac     2160

caaggctttc tggcgcgcgc gctgaatgac acgcgctatc tctcgcgcat cgcccgggat     2220

tacctcaccc ttgtctgccc cggcggtgtg cgggtgattc cggggcggat gacggctttg     2280

ctgcgcgcca agttcggcct gaatggggtc ttgagcctga gcggcgagaa aaaccgcgat     2340

gaccatcgtc accatgccgt ggacgcctgt gtcattggcg ttactgacca gggtctgttg     2400

cagcgctttg ccgaggccag cgcgatggct cgccagcaag gactggaaaa gctggtggaa     2460

acgatgccct tgccttggga aacctaccca gcgcatgtgc agcgcgccgt acaaaacatc     2520

tgggtcagcc accgccccga ccatgggcat gagggcggca tgatggaaga gacttcctac     2580

ggcatcagca aggatgggcg catcaagcag cggcgcaagg ccgatggcag tcaagggcgt     2640

gagatcagca atctgatccg catcagcgaa ccaagccagc ccgagcgcca cggcgtagac     2700

gccgaaggcc agcctttgcc ctacaaaggc tatgtcggcg gcagcaacta ctgcatcgaa     2760

atcacgcgca atgacaaagg caaatgggag ggcgaagtga tctcgacctt ccgcgcctat     2820

caaatcgtgc gcaaacatgg cgtggcgcgc ctgcgacatc cagagatggc acagaacggg     2880

aaggcgctgg tgatgcgcct gatgattgac gactgcgtgc gcctagaatt ggacggacgg     2940

gaagagacga tgcgtgtggt ggtaattccc aggaacggac aggtcttcat ggcgccactg     3000

cacgaagcca atgtggatgc ccgcaaccgg gataagaatg atccgttctc ctatatctcg     3060

aagatggccg gctccttcct aaaagccaaa gcccgccaca tcaccatctc gcccatcggc     3120

gagctgcacg accccggctt caagggc                                         3147


<210>  10
<211>  3063
<212>  DNA
<213>  Demequina sediminicola

<400>  10
atgactggca ctgacgccac agcacactcg cacacgccgt accgcctcgg gctcgatgta       60

gggacaggat ctttgggttg ggccgtcgtt gaactcgata ccgacggcaa tcctgtccgc      120

atcgtgcgca ccggctcgcg gatctatggg agcgggcgca aacccaagga cttttcatcg      180

ttagcggccg accggcgtgc cgcacgtcag atgcgcaagc aacgcgaccg ctatcttcaa      240

cgccgcacgc gcctcatgca tgaactggtg gccgccggtc tgatgcccga ggccgaggtg      300

gagcggcaga agctcaagga tctcaacccc tacctgctac gcgctcgtgg ggttaaagag      360

gaactgaccg cccacgaact tggcagggct ctctttcatc tccagcagcg ccgtggcttc      420

aagtcaaatc gcaagacaga ccgcaaggac gacgaccgca gcgcgatgaa gagcgccatc      480

gcatcgctcc aatccgactt gggcgacgac acccttggca cgtacatgtg gaagcggatc      540

cagaacggcg aatctgtgcg gtcccgtccg cgaaaggtcg ggtcaaagaa cgagtacgac      600

ttttacgtga accgcgcgat ggtcgaggat gagttcaatc agttgtggga ctaccaaagc      660

cagtcccacg gcgacctcct cacggacgaa gcccgcatcc gcgttcatga cgccatcttt      720

agccaacgtc cgctcaagcc ggtggacccg gggcgctgca cgttcgaaac agatcagcga      780

cgcgcaccga aggcactccc gagctctcaa ctgttccgca tctaccaaga acttaacgcg      840

atcagagtga tcgatccgtt ctcatcagac caagcagatc gacccctgac gcgtcaggag      900

cgcgatgccg gcgcatcgtt cctcctgggc agggtgaagg ccaccttccc tcaactcaag      960

aaggcgatgt ttgggcccac aaagctccaa ctctcacttg agtacggaga acgcaagaac     1020

atcctgggtg acgtcgtagg aagcgagttg cgcaaagcgc agcacatcgg cccagactgg     1080

gagacgtatg acctcgccac ccaggacctc atcgtgacga tcctgctcga ggcagacact     1140

gacgatgaag tgatcgagcg gcttcaggct gagtcgtcgc tatcgctcga tcaggtccac     1200

ggcgcgcttg aggcaccact cccggacgac tacctacggc tgagccatcg tgcgattggc     1260

aagatcctgc ctcatctcaa ggatgaatgg aatgaagagg gcaatgcacc ggtgatgtat     1320

gacgcggccg tccgtgccgc gggataccaa tcgcactcag agttccacag cggtgttctt     1380

gaagacacgc tcccctatta cgggaaggtg ctgaagcgat acacgcaaga ggtctccggg     1440

agcagccaag ctgctacgaa ccctgacgaa tgggagttcg gcaagatcgc caatccgacc     1500

gtgcacatcg gcctcaatca gatccgcacc gtcgtgaact cactgattga ccgctacggc     1560

ctgcccacac agattcatgt cgaggtagcc cgcgacttgg gccagtcggc tgagggaagg     1620

cgtgaagcag cgtccaaccg tgccaagaat gaacgagcaa acgaagcgct caacgcccgc     1680

ctgaccgaac tgggacaacg caccaacttt gccaatcggg agcggctgcg cctctacgat     1740

gagatctcag tcctcaatca caggtgtgtc ctgacaggca tccccatcga gatgtcgcga     1800

ctgttcacca atgactatca ggttgaccac atcctgccgt tctcccggac cctggacgac     1860

tcgcgcggaa acaagattct ggttcaccac acggccaatc agttcaaggg cgcccggagc     1920

cccttcgagg catactcgga gacggcagac tgggatcaca tccttcaacg cgcaagcgat     1980

gcctttggcg ctacgagccc caagttcaag cgcttttctg ccgacgccat ggacaggtac     2040

tcgaacggcg agcaagactt catcgcccgc caactcaacg acaccagcta cctggcacga     2100

gtgacacgcg agtatctagg gagcatcgtg gatcccgacc ggatcctagc cacaccgggc     2160

agacttactt cgctcttgcg ccaccactgg gggctcaatg gcctgctatc cgatgccgcg     2220

gagaagaacc gctcagatca ccggcaccac gccatcgatg cccttgtcgt tgcactcagt     2280

gagcgagtaa ctctaaaggc cgtcaccgac gccaaccgtc gtgccggtga ccaaggcatc     2340

gaacgcttgc tagtcgacct cccccagccg tgggagggct ttgcggatca tgcccgtgag     2400

tctgttgatc gcattgtggt gtctcacaag ccagatcaca atgagaaagg ccagctccac     2460

gaagagaccg cctatggagt cctggaaggg cccgacaaaa agggcaggtt cctcacccgc     2520

aagcgcatca cggaccctgc caaaggtgtg gtaggcagtt gggagcaacc caagtggcgt     2580

gacgtcattc cgctgtacag gcgcggcgag gggccagact cgacccttcc ctacaaggct     2640

tacattggcg gctccaacta ctgcatcgag atcgtccgaa ctgccaaggg gaaatgggct     2700

ggggaggtag tctccacgca caccgccaac acggccgagt atcgcgcttt catggcagag     2760

ccgggcgcgt atcgcgccca gagttacgcc ggtggtgacc tcgtcatgcg gctcatcgcc     2820

aatgacacca tcgcaatcga agtcggcgat gcgggtcgcc agatcatgag gctgtgccag     2880

ttggagacgg tcggagctat gtacttcgca aatgtgcgtg aaggcaacgt cgcagcacgt     2940

tcacgggctc gagacaacga cttttcgttg ctcaagaagg cggcaagcac acttcagcca     3000

ctcaaggctc ggagagtctt tgttgatccc attggcaggg tttttgaccc tgatttcaag     3060

gag                                                                   3063


<210>  11
<211>  3138
<212>  DNA
<213>  Fuerstia marisgermanicae

<400>  11
atgaactaca ttcttgggct ggatcttggt tccgcctcac ttggctgggc agttttggaa       60

tgcaccgaag tcgacggcag cctgcagccg actcgcatcg aacgcacggg tgtgcgaatt      120

ttcgaagccg gcgtggaagg cgacatcgaa cagggccgcg acgcctctcg agcagccaaa      180

cggcgagaag ctcgtcaacc gcgtcgtcaa aactggcgga cgcagcaacg aaaacgcaaa      240

ctgttccgac tattacagca acacggactg ctgccggctt cagaaaagga cgacgcgatc      300

agccgcaaag ccgtgttcga tcaacttgac aaggaactga ccgaaaaaca catcacggaa      360

ggcgatcaca cagcccatca gcacctgccg tacctgctgc gaatgctggc atctggcgca      420

aaggtgaagc catttgaact tggacgagcg atctacagcc tcgctcagcg ccgtggcttt      480

ctcagcaacc gcaaagctga cacagatgaa aaagaagacg gcgttgtcaa agcgagcatc      540

tccgaacttg gcggtcaaat agctggtcgc acgatcgctc agacgtttgt cgaagacatc      600

agtccggacc atgaagatcc tggtcgtcaa cgcatacggc aacgctacac agcccgtgag      660

atgtttcatg acgaattcaa tcgaattcga aaacagcagc aaccgcactt cgacctcgcg      720

gacaatgact gggataccgt ttataaaaca atcttctttc agcgtccgtt gaagtcgcag      780

cgtcaccgca tcggccgttg cgaaatcgat ggcggtcagc gttgtcttga tgctcttgat      840

gtctttcagc agtttcgtat ctggcacgcg gtgcagaatc tgcgactcgc ggacgcctac      900

agtttggggc gggacggtcg gctgacgctg gaagaacagc agaagattgt cgacgcattg      960

cagactcagg ccacgatgac gtggggaaaa gtcgttacgc tgctgggtct aaaacgcggc     1020

acgaagttca caattcagga atggaacacg aaagggctaa cagggcatcg caccaactct     1080

gcgatgatgc acgtcttcgg cgatgaatgg ctggacaggc cattggaaga acgagacgcc     1140

atcacaaagg aagtcgtcta cttccgcaaa ccatcagcga tgagaaaacg gggccaggaa     1200

gcatggggac tgtcagagga acaggccgcc ctgctaccgt caactcggct ggaagaagct     1260

cacgcccgac attccgccgc gacattggcc atctttgtcg aacgcatgag tcgtggcgaa     1320

gactattcca ccattcgcaa agacattacc ggcaaagacg acagcgaacc actcgaccag     1380

cttccaccgc tcagcaaagc cgggctggac atcaccaacc ccgccgtcat tcgtggcctg     1440

acagaacttc gcaaggttgt gaacgaactg gtgcggcaat acggcaagcc catcggcatc     1500

cgcatcgaac tgtctcggtc gctaaagaat tcgcgagaca aacgcatcaa gctgcacaaa     1560

gataacgaag atcgtcgtaa gcgtcgcgag aaggcgatcg aaggtattct gaagcaaatc     1620

cctggccggt actcgggcaa cgatatcgaa aaatggctac tcgcagaaga atgcggctgg     1680

cactgtccgt acaccggaag accgatttcg ccttccacac tgcttgggtc gcaaccacaa     1740

ttcgacatcg agcacatttt cccgcgccga tatctcgaca acagcttcag caataagacg     1800

ttgtgctatc acgaattcaa tcgcaacgtc aaaaagaacc aaaccgcctt cgatgcgtgt     1860

tccggcctcg atagctggga cgaaatcctg cagcgtgtca acaactttga tgggccggtc     1920

gcagcattaa aacgtaaacg ctttctgacc gcagcgaaag aaattccgga cggtttcact     1980

tcaaaacacc tcaacgataa tcgctacaac gcagttgtcg cgaagaaata cgtggccatg     2040

ctgtatggcg ggctgtcaga cgcggatggt agtcagcgag tctttgctgt cacgggcgga     2100

cacacggcac tgctgcggcg agaatggggc ctgaattcga ttttaagcgg aaccgaagag     2160

aaaacacgag acgaccatcg gcaccacgcc gtcgatgcgg tggtgatcgc attgacagac     2220

ccggcaagaa ttcaggcttt ggtaaacgct gcagagcttg ccgaaaagaa agcgtctcgc     2280

cgcttttacg aagccgtcca ggacccgtgg ccgaagttca gcagcaaagt cgctgattca     2340

atcaatgaaa tagtggtttc ccaccgtccg accagaactc ttccgggagc tctgcatgcg     2400

gaatcgattt atagcaaacc gcacatcgac aaagacggca acacgaacca tcgcattcgg     2460

aaacacatca ccaagctgtc tgcaaccgaa ttgaagaagg acaagattgt cgacccagcg     2520

attcgcgatc tggtgaaggc caaactgaaa gaactcggcg aatccaatcc ggcgaaagcc     2580

ttcgccgagg agaagaacca cccgttctta accgcaaaag acggtcgcaa aataccgatt     2640

cacaaagtgc gagtgtttgc cgacaagaaa cctcgggcaa tcgccaaaaa cgagcggcag     2700

cgctatgtcg ccagcggaaa agattccaac tttgcgtcca tgatttacgc cgtcgtcgac     2760

aaagacggcc acgaaatcaa atgggaacac aaagtcatca cccgcctgga ggcgcacgaa     2820

cgtaagactc gtaatcgtac ggtgaacgga gagaaagtgc tgctaccaga tcccaccgac     2880

ttcaacgacg acaagaagcg ggtcttcaaa ttcgcgttgt gtaagaacga tacagtgatg     2940

ctggaaggcc ccgacggaga cgacgtgatt tgtcggatac agaagatcag tcaagccgaa     3000

attcagctgt gtccactggc gacgccgtct gttcaaggaa aagctcgttc gaaatggaac     3060

caaatccaat caatcgacaa tctgcgaaaa tggaacctca gaacggttct aatttctccg     3120

acgggtattg agcatagg                                                   3138


<210>  12
<211>  3108
<212>  DNA
<213>  Nitrosomonas sp. Nm33

<400>  12
atgctgcata agatgcgcta tcgactggca cttgatttag gatcaacttc actgggctgg       60

gcgatgatta gattagatgc caatcagcga ccctgtgcgg ttatcaaagc gggggtgcgt      120

attttttcga acggccgcaa tccgaaagat ggttcttctt tggctgtaac ccgcagagaa      180

gcccgcgcca tgcgtcgtcg tcgtgatcgt ctgctcaaac gcaaggcacg catgatgcgt      240

acactcatag aatatggctt ttttcctgcc gaagaagcgc agcggaaggc actagaaaca      300

ctcaatcctt ataaattacg tgctgatgga ttggataaag cactcactcc ggctgaattt      360

ggccgtgtat tgtttcacat caaccaacga cgcggattca agagtaaccg caaaactgat      420

aaaaaagata ctgatagtgg tgcgctaaaa accgctatca gcaaattgcg cgaaatactg      480

aaaacagaaa actgccgcac cgtgggtgaa tggctgcaca aacgcaatca agcaggtcaa      540

actgttcgcg ctcgctaccg ccaagacaaa actatcaagg atgatggcaa ggcaaaaatt      600

gacaagtatt acgatctcta tattgaccgc gccatgattg agcatgagtt taatgaatta      660

tggagaaagc aggcagaatt caatccagcc ctattcagca gtgcagccta caccgacttg      720

aaagacgtat tgttgtatca acgtccgctt aaacctgtca aacctgggcg ttgcaccttt      780

atgtccgatg aagaacgtgc accgttagca ttacctagca cccaacgctt ccgtatgtat      840

caggaggtta ataatctgcg tatcctgcgg gaaggcttga aggaagaacc tctgacattg      900

cagcaacgcg atgatctaat tgttgtgcta gaaagaaaca ataaacgcac ctttacgcaa      960

attaagaaat tgcttggcgt tggcggtgca gttcagttca actttgaaga tccgaaacgt     1020

gaggaactta aaggtaatac caccaacgcc attcttggca aaaaagaaca ttttggtgag     1080

gcttggattg cgttcgacga agctaaacaa gacgccattg tcatgcaatt aatcaaagag     1140

gaaaacgaag ctaaactcat ccagtggctg caagatgaaa ccggcattga ggaagaacgt     1200

gctgaaatca ttgccaatgt tggattaccg gaaggctatg gcagtttagg tacaaaggca     1260

ttagcacgaa ttctgccaga actgcgccgt gatgtggtga catacgacaa ggcggtacaa     1320

gctgcaggct tcgagcacca cagtaaactc aatcaaaata gaggaattcc cggcatcacg     1380

ttcaaaatcg aaagcattga tcaagatact ggtgagatca aagaatttca cattcacaag     1440

gaattgcctt attacggtga atatctgcaa cgccacgttg gatttggcag cggcaaaccg     1500

gaagatccca tcgaaaaacg atacggcaaa attgctaacc ccaccgtgca tatcgggtta     1560

aatcaggtac gccttgcagt aaacgcgctc attaagcgct acggtcatcc cagcgaagtc     1620

atagtcgagg tggcgcgtga cttgaaacaa agcaaagagc agcgcagcga agaaaataag     1680

cggcaagctg aaaatcagca acgcaacaat cggttacgca ctgaaattgc tagaatttta     1740

cagattaatg aagagggcat ccgtcgcgac gacattgaga agatgatttt atggatcgaa     1800

ctcagtgctg atgtcgctga ccggaaatgc ccttattcag gtgtaccgat cagcgcaacc     1860

atgctcctga gcgacgaagt ggaaattgag cacattttgc ccttctcaca aacgctcgat     1920

gacagtctca acaacaaaac ggtggcgctc cgtaaagcca atcgcgttaa aggagaccgg     1980

acaccgtggg aagcacagca agattttgct gctcaaggct ggagctatgc ggatatcctc     2040

gccagggcag aaaacatgcg caaagaaaaa cgctatcgtt ttgccgaaga tggttataaa     2100

cgctggctga aggatgatgc gggattccta ccgcgcgcac tgaatgacac gcgctattta     2160

agcagagtgg cacgcgaata cctgcacctg atttgcccca atactcgtgt catccctggt     2220

cgcataaccg ccatgctgcg cagtcaattt ggtctcaaca aggtgctcgg cttgaacgga     2280

gaaaagaacc gcaatgacca ccgccaccac gcggtggatg cctgcgtaat tggcgtgact     2340

gatcagggtt tgttgcaaaa attcgcaaaa gccagtgcca gcgcgcgtga aaagcaactc     2400

aaccggctcg tggacaacat ggagtcaccg tggaaaaact accaagagca tgtacaacgc     2460

gccattgatg ctatttgggt tagccacaag ccggatcaca gccacgaagg cgcaatgcac     2520

aatgacacag cttatggctt gcgaggcaat ggcaaagtca gtttccataa aatgatggat     2580

ggtaagcgtg aatacattga agataatctc aaagtcattg aaattgccga tacaaaagct     2640

gcagaacgcc atggcttgtt gcccaatggt aaacctaaac cctataaagg ctacaaaggt     2700

gacagcaact actgcattga aattgttcgc aatgaaaaag gcagatggga aggagaggtt     2760

atttctacct ttgaggctta tcagctcgtg cgtgaacagg gtgccgcaca gcttcggcat     2820

ccggctttgg gtatcagcgg gaaacctttg gtaatgcggt taatgattga tgacacagtt     2880

cgtttagatg ttgacggtca atcttgcaca atgcgaatag cgaaattaag tagtaatggg     2940

caaatattca tggcagacat atgtgaagca aacgttgatg caagaaatcg aaataaagaa     3000

gattcatttg cctacatttc caaaatggca ggttctcttc aaacagccaa agcacgccgc     3060

gtcaccattt ctccgattgg cgaactccgc gattccggtt tcaagggg                  3108


<210>  13
<211>  3186
<212>  DNA
<213>  Novosphingobium sp. SYSU G00007

<400>  13
atggagaagc gcctgggact ggatatcggg acaaactcga tcggttggtg cctgtatgaa       60

ggcgacagca ttctcgatat cggcgtgaga atcttctcgg acggacgaga cccgaaatcc      120

ggggcaagtc ttgccgttga tcgccggaat gcgcgtgcca tgcgtcggcg ccgcgatcgt      180

tatcttggtc gtcgatccgc tctcatcaag gcgctcaaag cccatggcct tttccccgca      240

gaacaggatg cggcaaaggc gctcgaacgc gaggatccat acagcttgag ggttcgtgcg      300

ctcgatcatc ggctggatcc gcatcagatc ggcagggcga tctttcacct gaaccagcgt      360

cgtggtttcc gctctaaccg caaggccgac agggtattgg gcgatcagga aagcggactg      420

atttccaccg ccactcgtgt tctggatgag gcgatggcca aaagcggcgc gcgcaccctc      480

ggcgagtttc tcgcttcacg cgacacccgc agagtgcgca tgcggcctga cgtcaagggc      540

tatgatttct atcctaatcg gcaacactat ctcgaagagt tcgagaagat ctgggacgcg      600

caatcgcaat accaccccga tctgctgagc caacaggcga aatccgccat ccaccgaatc      660

atctttcacc agcgcccgct taagccgcag gctgtcggca catgcacttt cgccgggtta      720

cacggcatcc ctggcgatga aacgcgcttg cccaaagccc atcccctgtt ccagcagcgc      780

aggctttacg aggaagtcaa ccagcttgag atcgtttgtg caagcgcccc tgcccgcaag      840

ctgacgcgcg acgaacgcga tgccctcatc ctcaagctgc aggacaaaaa gaaggtcact      900

ttctccaccc tcgcgcgcac cataagattg aaggagggtg aacgcttcaa caaggaaagc      960

gagaaccgga aggatctggc aggcgacgaa gtgcgtgccg agatgagtga caagacgcgc     1020

tttggcaggc gatggtttca cctttccctt gatgagcagt ggtctgttat cgaccgcttg     1080

ctgaacgagg aaagcaccga agacctgctg gcctggctcg aaaaggaatg gtcgctgccc     1140

agcgatgtcg ccgaggcagt agccaatgcg catctgccag acggccatgg caggtttggc     1200

cttactgcca ccgttcgcct gttggaacac ctcaaggctg acgtggtgac ttatgccgaa     1260

gcagcaagac gtgcaggctt ccaccacagc gactttcgcg atggcgcgtg ctacgatgag     1320

cttccctact acggggagat actttcccgc gagatcgcgc caggcaagga cgaatacggc     1380

gatccgctgg aacggcaatg gggcaagatt accaatccca ccgttcacat cggactgaac     1440

cagttgcgac ggctgatcaa cgcgcttgtc agacggcacg gtcgtcccga tttcattttc     1500

gtcgaactgg cgcgtgagct gaagctgaac gaaaagcaga aggccgacca caagcgccgg     1560

atcaagcaga caaccgatgc cgcccgcgcc agggcagaaa agctgcgcga gatcggccag     1620

cgcgacagtg gcagcaaccg gatgctcctg cgcatatggg aagaactgaa tccctccaat     1680

ccacttgacc ggcggtgccc ctattgcgcc gaacccattt cgatcgagat gctgatgagc     1740

ggatcagccg atatcgatca cattgttccc tattcgcgtt gccttgatga cagcgccgcg     1800

aacaaggttg tcgcgcataa ccactgcaat cggcagaaag gaaaccgcac cccatgggaa     1860

caatgggggc aaacgacgcg ctggcccttg atccaggagc aggtcgctcg catgcatcgg     1920

tccaagcaat ggcgctttgg ccccgatgcg atggaacggg tggaccggga tggtggcttc     1980

atcgctcgcc agcttaccga cacccagtat ctttcgcgca ttgcggcgca gtatctttcc     2040

gctctctata cacccgatga gggacggcgg gtctatgccg tgactggccg gttgacggcg     2100

atgctccgcc gactgtgggg actgaatgac atcctgcccg atcacaactg ggttctgaac     2160

ccgcacagca acgcacccaa gaaccggctt gatcaccgcc accatgccat tgatgctgcg     2220

gtggttggtg ccacaactcc ggcaatgatc cagcaggttg ctagagcggc agcacgcgcg     2280

gaagagcagg atcttgaccg gctctttgcc gatctgccac cgccatggcc aggcttccgc     2340

gaggaactgc agggccgcat catggccgct gttgtcagtc acaagccgga tcatgggcgc     2400

aaggggcgtc cccttccagg gcgagacagc acctcaggcc gcctgcacaa cgatacggcc     2460

tatggcttca ccggaaggcg caatgccaag ggcatgccga tcgtggtcac gcgaaagccg     2520

ctgctggccc tcaagcccga agacctgacc gatccggaaa gaatacccga cccggcactg     2580

cagggcgcgt tgtttgaagc cacgcggggc gcaaccggca aggactttga aaaggcgctg     2640

cgcgactttt cgcgaaggga cggcccttat cagggcatcc ggcgcatacg gttgaccgaa     2700

gcgctcaacg tgattccgat ccgtgatcga acaggacacg cctataaggg tgtaaagggc     2760

gatgccaatg cgcgtttcga tgtctggcgg cttcctgatg gcaaatggat cacgcggtgg     2820

aaggaccggg acggcatcga acattccggc atagtatcgc tgttcgatgc acatcagccg     2880

agccaagtct atcaccgccc ccaccctgcc gcgaagaagg tgcttagcct gcggcagaat     2940

gatctcgttg cggttgaaca cgatggcgac ccaggcaaga tcatgcgtgt ggtcaagttt     3000

tctgccaatg gctcgatcac cttcgcccca cataacgaag ccgggccgct aaagacgcgt     3060

gataccgacc ctgccgatcc gttccgttat gtcaccactg ttgcgagcgg actgaagaag     3120

atgcgcgcgc ggcaggtgcg gatcgacgaa ctaggaaaag tccacgatcc ggggccgcgc     3180

gaagac                                                                3186


<210>  14
<211>  3225
<212>  DNA
<213>  Paracoccus bengalensis

<400>  14
atgaccacta cactcggcat tgatcttggc acgtcgtcgt tgggctggtg tctcatcgaa       60

gacgaacacc gcatcctcga tctcggcgtg atcatcttca gcgccgccgc cggtgccggg      120

cgcgacccgc aatcgggcgc acccctcgcc gaagcgcggc gcgaggcccg ttcggcgcgg      180

cggcggcggg acaggttcat cggtcgccgc tcggctcttc tggacaagct gatcgcgctc      240

ggcctgctgc ccggagaccc gcccgcgggc catgggcggc ggcgcaacca ggcgctgccg      300

aatgccgaga cgaaggcgct ggccgacacc gatccccatg tcctgcgccg ccgggctttg      360

tcggagccac tttcgccgca cgagatcggc cgggcgatct tccacctcaa cacccggcgc      420

ggcttcaagt cgaaccgtaa ggccgaccgg ggccgaaacg agcccgaaac cggcaagatc      480

gccaccgccg gccaggcgct ggacgcggcc ttgggcaagc gcaccctcgg ccaatttctg      540

gccgaccgga tcgacgccgg gcaaccggcg cgggtgcgga tgggtggcga gaaccaggcc      600

tatgatttct atccccagcg cagccatctc gaggcggagt tcgcggcgat ctgggaggcg      660

caggaacacc accaccccga gttgctgacc gacacggccc ggaccgcgat ccatcgcatc      720

ctgttctttc agcgcccgct gaaaacgccc gaggtgggtt tttgcacctt cgccggcatg      780

agcggtgtgc ctcacgacga gcgccggctg ccaaaggcgc atccgctgtt ccaggaacgg      840

cggctctacg aggaggtgaa caacctcaag gtagtcgccg ccggagccgc tgcgcgcgac      900

ctgacgctgg atgaacggga ccggctgatc ctcaagttgc gcgacaacaa gaaagtcacc      960

ttcgccactt tggccaagaa ggtgctgaaa ctggccgagg gcgagcggtt caacaaggaa     1020

agcgaagccc gcaaggacct ggcgggcgac gaggtccggg ccgagatggc ggacaagaag     1080

cgcttcggca atcgctggac gcatttcccg ctggagcggc agttgcagat catcgaccgt     1140

gtgcagaacg aggaaaatcc cgatatcctg ctggcctggc tgcaatccga ctgcgggctg     1200

gacaaggcgg cggcggtcgc ggtggccagg acgaacctgc ccgaggggca cggccgcttc     1260

ggcgagaccg cgacccggcg gctgatcgcg gctctaaagg ccgaggtcgt tacctatgac     1320

aaggccgcgc tggcggcagg gttccaccat agcgatcacc ggacgggcga ggtttacgac     1380

ctcctgccct attacggcga ggtcctgacc cgtgagatcg cgcccggcaa ggcggagtac     1440

ggcgatccgc tcgaacgcca atatggcaag gtcaccaatc ccaccgtcca tattggcctg     1500

cgccagttgc aaaagctggt gaatgcggtg atcgcccggc atggcaggcc cgaccggatc     1560

gtcatcgaac tcgcccgcga actgaagctc aatgacaagc agaaggacga gcatcagcga     1620

cggatcaggc gggataccga ggcggcgatc cgcaggggcg agaagcttgt tgaggcgggt     1680

attgccgata ccggcgccaa ccgcgccctg atgcggcaat gggaggagct gaacccgtcg     1740

aaccccctcg accgtcgctg cccctactgc ggcgagccga ttggcatggc gcagattttc     1800

aatagcctag cggatatcga ccatatcatc ccctattcca ggtcgctcga cgacagcccg     1860

gcgaacaaag ttttggtcca tcgcaactgc aaccgccaga agggcaacaa gacgccctgg     1920

gatcggtggc acgaggacga ggcgaaatgg gaaatcatct cggcccaggt tgcgcggatg     1980

cacccttcga aacaatggcg ctttggcccc gacgcgatgg agcggctgga acgcgacggc     2040

ggcttcgccg cccgccaact gactgatacc cagtatctgg cgcggatcgc ggacaaatac     2100

ctgcgcggcc tttatccgac tgctgatgag ggccgggtcg atgtcatccc cgggcgcatg     2160

accgcgatgc tgcgccgggt ctggggcctg aacagcctgc tgcccgacca taacttcgtc     2220

gagaacgaac attccagcgc accgaagaac cggctggatc accgccacca tgcgattgac     2280

gccacggtcg cggcggtgac atctctgtcc cggatgcagc agatcgcagc cgcagcggcc     2340

cggtcggagg aaaaggaatt ggagcgcctg ttcgacgatc tgccgcatcc ttgggacggc     2400

ttccgcgagg acctgggcgc gtgccttgcc cgcacagtcg ccacgcacaa gcccgatcat     2460

ggacgcagcg cgaaaccctc gcgccaccgc gatgtgacgg cgggcaagct gcacaacgac     2520

accgcctatg gcctgaccgg cctgaagacc accgatggca agacccctat cgtcgtgcac     2580

cgcgttctcc tggcctcgct gaagcccacg cagatcgccg accccgactg tattcccgac     2640

gaaaccctcc gcaacgccct gtggctcgcc acccgggact gttccggcaa ggccttcgat     2700

caggccctag cgcgcttcgc caaggagcat ccggtgttca agggcatccg ccgggtgagg     2760

atacgcgagc cgctgaacgt catcccgatc cacgacaggg aaggaaaacc ttacaaaagc     2820

tatgccgggg cgtccaacga ccgatacaat gtctggcgga tgcccgacgc ttcctggcgg     2880

catgatgttg tgtccacctt caacgcgcac cggagcgatt atcgcgacct tcgcccgcac     2940

ccagcggcga aaaaggtttt atcgctacgc cagaacgata tgatcgcggt ggagcgtaat     3000

ggtgggcttc gggagattat gcgggtcgtt aagttcaacc aagccgggcg gctgactctt     3060

tgtccgccga acgagggcgg caagcttcag aaccgggacg cggcaccgaa cgacgccgat     3120

ccgttcaaat acacttatct ttctcccagc tccctaaaaa acgccaaggc ccgtcaggtc     3180

cgcatcgatc cactcggtcg cgtcttcgat cccggcccac gcgaa                     3225


<210>  15
<211>  3135
<212>  DNA
<213>  Parvibium lacunae

<400>  15
atgaaaaaca aaatgcaata ccgtttggcc cttgatttag gcaccacctc acttggctgg       60

gccatgcttc gtgtaaaacc caatcccgaa ggccgtttag agccttttgc cgtcgtaaaa      120

gcaggtgtgc gaatcttttc agatggccgc aacccgaaag atggttcctc attagccgtg      180

acccgccgcg aagcgcgtgc catgcgccgc cgccgcgacc gcttactgaa acgcaaagca      240

cgtatgctgc aacagctcac tgcctttggc tttttcccca ccgatctggc cgagcgcaaa      300

gcactggaaa cgctcaaccc ctacgaactc cgcgccaaag gcctagatga accactcagc      360

ccttatgagt ttggccggtc gctcttccac attaaccaac gccgtggctt taaaagtaac      420

cgcaaaaccg acaaaaaaga aaacgatagc agcgccctca aagccgccat tcggcgtgtg      480

gcgagcgaaa tcgacggcaa tcaggcgcgt accgtcggcg aatggctcta caagcggatg      540

ctcaatggtc agcccgtaag aggtcggtat cgcgaaacca aggtacaaaa agaagacggc      600

aaaaccaaaa tcgataaaag ctacgatctc tacatcgacc gcgccatggt agaggccgaa      660

tttgaagcgc tctgggccaa gcaagcctcg ctaaatcccg ccgtctacag cgagcaagcc      720

aaggccacgc taaaagatgt tttactgttc caacgcaatt tgcgcccagt taaacctggc      780

cgctgcacac tgattcccac tgaagaacgt gcgccactgg ccctaccgag tacgcaacgc      840

tttcggattt atcaagaagt aaataacctg cgcatactac gtgaaggttt aaaagacgaa      900

gcacttacac tggtgcagcg tgatgcgctc gtcaccgcgc tggaacagaa caacaagcgg      960

acttttgctc aaattaaaaa attgctcggt cttgatgggc aaacccaatt taattttgaa     1020

gaccccaaac gccaagaact caaaggcaat accaccagcg ctattctgag ccaccccaaa     1080

cattttggtg acgcttggtt tggttttgat gaagccaagc aagacgggat tgtgtgtcag     1140

cttctcaacg aagaaaacga aagcgcgctg attcgctggc tgatggatca cacaggggtg     1200

gatgaggccc atgccgaagc tattgccaat gcggcactcc ccgaaggcta tggctcgctc     1260

agccgcgctg ccctcgccaa gattctgccc gagctccgca aagcggtgat tacctatgac     1320

aaagcggcgc aagccgccgg gtttgaccac cacagccaca ttagccccag taccaccggc     1380

gaaattttgc ccgaacttcc ctattacggc gaggcgctgc aacgccatgt gggctttggc     1440

acgggcaacc ccgatgatgt gcctgaaaaa cgctacggca aaatcgccaa ccccaccgta     1500

cacattggtt taaaccaagt gcgcaaggtg gtgaatgcgc tcattaaacg ctatgggcac     1560

cccagcgagg tgattgtaga agtggcacgc gacctcaagc aaagcaaaaa gcagcgcgat     1620

gaagaaaaca aacgccaggc cgaaaaccaa aaacgtaatg agcggattcg tcaagatatt     1680

gccgccatgc gtcctgatag aagtgaagag cgcgtgaccc gtacagatat tcaaaaatgg     1740

atcttatggg aagagctaag ctttgatcca gcgaatcgat gctgtcccta ctcgggcgta     1800

caaatcagcg ctgaaatgct aatgagtgat gcggtggaaa tcgaacacat cttgcccttc     1860

tctcgcacct tggatgacag cctgaataac aaaacggtgt ccatgcgcca agccaaccgc     1920

attaaaggca accaaacacc ctttgaggcc tttggtaaag acaatgctct gggcgtgaac     1980

tacagcgaca ttctgatgcg cgcgcagcag atgcccaaag ccaagcgcaa acgtttcgct     2040

gaaaatgctt tggaagaatg gctgcaaaat gaaaaaaatt ttcttgcccg cgcgctgaac     2100

gacacccgct acctcagccg cgtggcacgc gaatacgtca gcctgatttg cccacaagcc     2160

acacgcgtga ttccgggaca aatgacggca cagctccgcg ccaaatttgg cctgaatgac     2220

atactcggtt tagatggcga aaagaaccgc aacgatcacc gccaccatgc cgttgatgcc     2280

tgcgtgattg gcgtcaccga ccaaggcttg ctccagcgat ttgcctatgc cagcgccagc     2340

gcccgcgcaa atggactagc gcgtttggta gacaccatgc ctgacccttg gcccagctac     2400

cgccagcacg tacaacgggc ggtacaaaat atttatgtca gccacaaacc cgaccacagc     2460

catgaaggcg caatgtttga cgaaaccatc tacagcgcca ctgggaaaag tcgcagcgca     2520

gctaaagatc gcacagtcat tccttttatt gctaaaaatt ggagccatcc tgacgaccac     2580

aacaaacagc gtccgttcaa gggcttgata acagatgttt ctcaacggca tcaaaacaaa     2640

ccctacaaag gattactatc aaacagcaat tactgcatcg aaatttattc ggatgaagca     2700

ggctggggtg ggcatgtact caaaactttt gatgcctatc aaatcgtcag ggcacacaaa     2760

aatgctagtg agggtatgca agcgctacgt aataaacata gcagccagaa tgggcaccca     2820

ctagttatgc gtttgatgat cggggactac attcgcgcag aaatagatgg tttcttattg     2880

ctgctccaag tacttaaaat caatagttca ggctcgatca ccttcattaa gccgaatgaa     2940

accaatatca gcgcacggta cttagcaaag ctagcagcac aaaaagctca aaaagaaggt     3000

aagccattcg atgacattgc gctgaatgat gttttctttc agaaagcaat atctgccgat     3060

agtttacggt tatttaaagc taggcctgtc accctctccc ccatcggtga gctacgcgac     3120

cccggcttta aaggc                                                      3135


<210>  16
<211>  3213
<212>  DNA
<213>  Pelagicola sp. LXJ1103

<400>  16
atgcgacttg gccttgatat tggaacgaac tccatcggct ggtggcttta ccggacggaa       60

aatgaccaga taacgtgcgt cgtcgatggc ggagtgaggg ttttctcgga tgggcgggat      120

ccgcagtcaa aggagtcgct ggccgtcgat aggcgcgtgg cccgtgcgca gcgccgtcgc      180

cgtgacagat acttgcgccg caaggctgct ttgatgaaac ggatggctga ggcaggcttg      240

atgccagccg atcccgtgca ggccaaagcg ttgcaagctc ttgatcccta tgaccttcgg      300

gcacgggggc tcgatgaggc tttgccgctg gcgcatttcg ggcgggcgct gtttcacctc      360

aaccagcgac gtgggttcaa atccaatcga aaggccgacc gcggcgataa cgaaagtggt      420

aagatcaagg atgcgactgc acggctggat tgggcgatgc gcgatgcacg cgcacgcacc      480

tatggcgagt ttctgcatat gcggcaggac aaggccgatg atccgcgtcg cgtcccgacg      540

gtgcgcacgc gcttgtccgt ggcgcggcgt gacaatgccg aaaaagagga ggcagggtat      600

gatttttacc ccgaccggcg gcacctgtca gaggagtttg acgcgctatg ggccgcacag      660

gcggaacatc acaccaccct gacggacgat ctgcgcgacc agatcaagac gatcatcttt      720

caccagcgcc ccctgaaggc gcctgaggtc ggtctgtgtc tattcacgga tgaacggcgt      780

attccgtctg cgcatccctt gaaccagcgg cggatcctgt tggagacggt gaatgggctg      840

cgaattgttg cgcgagggga ggcggcacgt gggttgactc gtgaagaacg tgaccagatc      900

gttcatgggc tagataacaa aggacatacg aaaaccctgt cgggaatgtc gatgaaactc      960

agggcaattg gcaaggtgat caaacttagg agtgaccaaa gtttcacgtt ggagactgcc     1020

aaccgggatg ccattgcctg cgaccccgtc cgtgctagcc tgtcgcatcc agaaaggatg     1080

ggcggggtct ggaccacact ggacgaagac gctcaatggg acgtggtgca acgcctccgt     1140

gcggtgcaga gtgataccga gcatgaggcg ctggttgatt ggttgatggc cacccacggg     1200

cttggccagg attatgcgca agcaacggcg aatgcgccgc tgcccgaagg ttacggacgg     1260

cttgggctga cggcaacgcg caagattctg gcggcattgg aggctgatgt gatgtcctat     1320

agcgatgctg tggccgcctg tggttggtcc cattctggcg gaccaacggg tgaggtgttg     1380

gaggctctgc catactacgg tgaaattctg gaccggcatg taatcccggg aacaggtgtg     1440

aaaactgacg aggacgtcaa acgcttcggt cgtattacca accctacggt ccatatcggg     1500

ttgaaccaga tcaggcgact ggtgaaccgg atcatttgtg tgcacggcaa gccggaccag     1560

atcgtggtgg aggttgcccg cgacctaaag aactccgagg atcaaaagcg tgagattcag     1620

aagacgatca ggaaaaatac ggatgacgcg atcaagcgcg gcaaaaagct ggttgaagaa     1680

ctggggcaaa aagacacagg cgcaaaccgg ttaatcctgc ggctgtggga aaaccttggc     1740

aatgacgtta tgacccgcca atgcccctat tctggcaagc gtatcagtgc ggcgatgttg     1800

tttgacgggt cgtgtgatgt tgatcatatc cttcctttct cacgtacgtt ggatgatagc     1860

atttggaaca agaccctatg cttgaaagag gaaaatcgga aaaaggctaa caagacgccg     1920

tgggaggtct ggggcgaaac agaccagtgg gacgtgatcg tcgccaacct caagaatctt     1980

gatagaaagc aggcatggcg ctttgccccc gatgcggtgg aacggtttga gggcgagaac     2040

gacttttccg cccgtgcact aaaagatacc caatacctgt ctcgtgtggc acgggcttat     2100

ctggatgcgt tgtatgacgg ggcggacggc aaatcccatg tttgggttgt gccgggccgg     2160

ttgacggaaa tgctgcgccg ccattggggg ttgaacggga tcgaggtgct gacggacagc     2220

gacgcgcaaa ccgtgaaatc caagaaccgg caggaccacc ggcatcacgc catcgacgcc     2280

gccgtggtcg cagccaccga ccgcagcctg atccagcgga tcagcaagat agccaagcac     2340

gacgaacagg cgggcgccga acaggtcgcg cggtccgtcc cgccgccttg ggacggtttc     2400

cgtgatgatg tcgccggaca gatcgggcgg atcatcgtca gccacagggc agatcacggg     2460

cgcattgatc cgaccgcgcg cgcacaaggc agtgacacga cagcggggca gttgcatatg     2520

gatacggctt acgggatcgt tgacggtggg catgtggtca gccgcaaacc gctgatgtcg     2580

cttggtgcag gtgatatcag gaaaatccgc gatcccgatt tgcagcgtca tctcacgcgt     2640

gtcacgcgcg gtttggacaa gaaggaattt gaacaggctc tggcctcttt tgcggcgtcg     2700

cgcaaactgc cggaccaaag cgaaaaccct tatttcgggc tgcgacgtgt gcggcttctg     2760

gatgccttgc aagacagtgc ccgtgtgccg gttagaaacg ccacaggcaa tatctacaag     2820

gcctacaagg caggtagcaa ccattgctac gaggtgtggc ggatgcctga tggcaaggtc     2880

aagccttggg caatctcaac gtttgaggcg caccaatccg gcgatgggtc caagccccat     2940

ccggctgcaa aacggctctt gcgggtgttc aagcgggata tggtggtaat tgaacgtaaa     3000

gggataacgg tgatctgcta cgtccagaaa atggacgttg ccaacggcct gtttctggtg     3060

ccgcataccg aggggaatgc cgatgcgcgc aaccgcgaca aggaggatga tttcaaattc     3120

atccagatgt ctgcggcgtc tttgattaag gccagaatcc gccgcgttca cgttgatgaa     3180

atgggccgga tgcgcgaccc gggcccgccc cgt                                  3213


<210>  17
<211>  3144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-59 DNA optimized for expression in human cells

<400>  17
aacgtgtgga aaggcaccgg cttcgtgtcc cggaagcgga acatcatcag atacagactg       60

gccctggatc tgggcagcac atctcttgga tgggccatcc tgagactgaa cgccgataat      120

cagcccaccg ccattctgaa agccggcgtg cggatcttca gcgacggcag aaatcctaag      180

gatggcagca gcctggccgt gactagaagg gctgctagag ccatgcggcg gagaagagac      240

agactgctga agcggaaggc ccggatgctg gataagctga tcgcccacgg attcttccca      300

caagacgaag ccgccagaaa ggccctggaa gtgctgaacc cttatcagct gagagccgag      360

ggactgcaga gggctcttat gcctggcgaa tttgccagag ccatgttcca catcaaccag      420

cggagaggct tcaagagcaa cagaaagacc gacaagaagg acagcgactc tggcgccctg      480

aaaacagcca ttagccagct gagacagcag ctgcagaacg agaatgccag aacagttggc      540

gagtggctgt ggcagagact gcaagctgga cagggcacca gagccagata cagggaaacc      600

agaatcgcca ccgataccgg caagggcaag atcgacaaga gctacgacct gtacatcgac      660

cggcagatgg tggccgatga gtttgatgct ctgtgggccg tgcaggccgc cttcaatcct      720

gtgctgttta atgagcaggc cagagccgag ctgagagaca ctctgctgca tcagaggcca      780

ctgaggcctg ccaagcctgg aagatgtaca ctgctgcccg aggaagaaag agccccactg      840

gctctgccta gcacacagcg gttcagaatc ctgcaagaag tgaaccacct gaggattctg      900

caccccgacc tgagagaaga ggccctgaca ctggatcgga gaaatgccat tgtggccctg      960

ctggaaaacc ggggcaaagt gacattccag gccatgcgga gaacactgaa cctgggagat     1020

gccgtgcagt tcaacctcga ggacgccaag agaagagagc tgaagggcaa cgccacaacc     1080

gccgctctga gcaagaaaga actgtttgga gccgcctggc acgacttcga tgaagccctg     1140

caggatgaca tcgtgctgag actggtcaca gaggaatctg aggccgaact ggtgcagtgg     1200

ctgatcgaga atactggcgt ggacgaagcc agagctaccg ccattgctaa taccggcctg     1260

cctgaaggct acggcagcct gtctagaaaa gccctggcca gaatcgtgcc agctctgagg     1320

gccgaagtga tcacctacga taaggctgtg caggcagccg gctttgccca ccactctgat     1380

ctgagattca gcttcgagta cgacagcgcc gacgtggaac aagtgggcga gagaatcgat     1440

aagaccaccg gcgagattct gcccgtgtcc gcctttaagc agctgcctta ttatggcaag     1500

gccctgcaga gacacgtggc ctttggatct ggaaaccctc aggaccccga ggaaaagaga     1560

tacggcaaga ttgccaatcc taccgtgcac atcggcctga atcaagtgcg gagagtggtc     1620

aacgacctga tcagaagata tggcagaccc accgagatcg tggtggaact ggccagagaa     1680

ctgaagcaga gcagagagca gaagctggaa gcccagagaa agcaggccga caaccagaag     1740

agaaacgcca gaatcagggc cgagatcgcc cctatcctgg gcatctctga ggaaagagtg     1800

aagcacgccg acatccaaaa gtggattctc tgggaagaac tgagcttcga cgtggccgac     1860

agaagatgtc cttacagcgg agtgcagatc agcgccagaa tgctgctgag cgacgaggtg     1920

gaaatcgagc acatcctgcc tttcagccag acactggacg acagcctgaa caacaagacc     1980

gtgtccatgc ggcaggccaa ccggatcaag ggcaatagaa caccctggca ggccaggcag     2040

gattttgaag cccaaggctg gccttacgag ggaatgcagc aacgggccga aagaatgccc     2100

agagccaaga gatacagatt cgcccctgac ggctatgagc ggtggctggg agaagatcag     2160

ggattcctgg ctagagccct gaacgacacc agatacctga gccggatcgc cagagactac     2220

ctgacacttg tgtgtcctgg cggcgttaga gtgatccctg gaagaatgac agccctgctg     2280

agggctaagt ttggcctgaa tggcgtgctg agcctgtccg gcgagaagaa tagagatgac     2340

cacagacacc acgccgtgga tgcctgtgtg attggagtga ctgatcaggg cctgctgcag     2400

agatttgccg aagcctctgc catggccaga cagcagggac tcgagaagct ggtggaaacc     2460

atgcctctgc cttgggagac ataccccgct catgtgcaga gagctgtgca gaacatctgg     2520

gtgtcccaca gaccagatca cggccacgaa ggcggcatga tggaagagac aagctacggc     2580

atcagcaagg acggcaggat caagcagaga agaaaggccg atggcagcca gggcagagag     2640

atcagcaacc tgattcggat cagcgagccc tctcagcctg aaagacatgg cgttgacgcc     2700

gaaggccaac cactgcctta caagggctat gtcggcggca gcaactactg catcgagatc     2760

acccggaacg acaaaggcaa gtgggaaggc gaagtgatta gcaccttccg ggcctaccag     2820

attgtgcgga aacatggcgt ggccagactg aggcatcccg agatggctca gaatgggaaa     2880

gccctcgtga tgcggctgat gatcgatgac tgcgtgcggc tggaactgga tggccgggaa     2940

gaaaccatga gagtggttgt gatccccaga aacggccagg tgttcatggc ccctctgcac     3000

gaagccaacg tggacgccag aaacagagac aagaacgacc ctttcagcta catctccaag     3060

atggccggca gcttcctgaa ggccaaagcc aggcacatca caatcagccc tatcggcgag     3120

ctgcacgacc ctggctttaa aggc                                            3144


<210>  18
<211>  3060
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-61 DNA optimized for expression in human cells

<400>  18
accggaacag atgccaccgc tcacagccac acaccttaca gactgggcct cgatgtcggc       60

acaggatctc ttggatgggc cgtcgtggaa ctggacaccg atggaaatcc tgtgcggatc      120

gtgcggaccg gcagcagaat ctatggcagc ggcagaaagc ccaaggactt tagctctctg      180

gccgccgata gaagggccgc cagacagatg agaaagcagc gggatagata cctgcagcgg      240

cggacaagac tgatgcatga actggtggct gccggactga tgcctgaggc tgaggtggaa      300

agacagaagc tgaaggatct gaacccctac ctgctgagag ccagaggcgt gaaagaagaa      360

ctgacagccc acgaactggg cagagccctg tttcatctgc aacagcggag aggcttcaag      420

agcaacagaa agaccgaccg gaaggacgac gacagatccg ccatgaagtc tgccattgcc      480

agcctgcagt ctgacctggg agatgataca ctgggcacct acatgtggaa gagaatccag      540

aatggcgaga gcgtgcggag cagacctaga aaagtgggca gcaagaacga gtacgacttc      600

tacgtgaacc gcgccatggt ggaagatgag ttcaaccagc tgtgggacta ccagagccag      660

tctcacggcg atctgctgac cgatgaggcc agaattagag tgcacgacgc catctttagc      720

cagcggcctc tgaagcctgt ggaccctggc agatgcacct tcgagacaga tcagagaagg      780

gcccctaagg ctctgcctag cagccagctg ttccggatct accaagagct gaacgccatc      840

agagtgatcg acccctttag cagcgaccag gccgatagac ctctgaccag acaagaaaga      900

gatgccggcg ctagtttcct gctgggaaga gtgaaggcca cctttccaca gctgaagaaa      960

gccatgttcg gccccaccaa actgcagctg tctctggaat acggcgagcg gaagaatatc     1020

ctgggcgacg ttgtgggctc tgagctgaga aaagcccagc acatcggccc cgactgggag     1080

acatatgatc tggccactca ggacctgatc gtgaccatcc tgctggaagc cgacaccgac     1140

gacgaagtga ttgaaaggct gcaggccgag agcagcctgt cactggatca agttcatggc     1200

gccctggaag cccctctgcc tgatgattat ctgagactga gccacagagc catcggcaag     1260

atcctgcctc acctgaagga cgagtggaac gaagagggca acgcccctgt gatgtatgat     1320

gccgctgtta gagccgccgg atatcagagc cacagcgagt ttcatagcgg cgtgctggaa     1380

gataccctgc cttactacgg caaggtgctg aagcggtaca cacaagaggt gtccggatct     1440

tcccaggccg ccacaaatcc tgatgagtgg gagtttggca agatcgccaa tcctaccgtg     1500

cacatcggac tgaaccagat cagaaccgtg gtcaacagcc tgatcgacag atacggcctg     1560

cctacacaga ttcacgtcga ggtggcaaga gatctgggcc agtctgccga gggaagaaga     1620

gaggctgcca gcaacagagc caagaatgag agagccaacg aggccctgaa tgccagactg     1680

acagagctgg gccagcgcac caatttcgcc aacagagaga gactgcggct gtacgacgag     1740

atcagcgtgc tgaatcacag atgcgtgctg acaggcatcc ccatcgagat gagcagactg     1800

ttcaccaacg actaccaggt ggaccacatc ctgcctttca gcagaaccct ggacgacagc     1860

cggggcaaca agattctggt gcatcacacc gccaaccagt tcaagggcgc cagatctcca     1920

ttcgaggcct actctgagac agccgattgg gatcacattc tgcagagagc ctctgacgcc     1980

tttggcgcca cctctcctaa gttcaagaga ttcagcgccg acgccatgga cagatacagc     2040

aacggcgagc aggactttat cgccaggcag ctgaacgaca ccagctacct ggccagagtg     2100

acaagagagt acctgggcag catcgtggac cccgacagaa tccttgctac acctggcaga     2160

ctgactagcc tgctgaggca ccattggggc ctgaatggac tgctgtctga cgccgccgag     2220

aagaacagaa gcgatcacag acaccacgcc atcgatgctc tggtggtggc cctgtctgag     2280

agagtgacac tgaaagccgt gaccgacgct aatcggagag ccggcgatca gggaatcgaa     2340

agactgctgg ttgacctgcc tcagccttgg gagggatttg ccgatcacgc cagagaaagc     2400

gtggaccgga ttgtggtgtc ccacaagcct gaccacaacg agaaaggcca gctgcacgaa     2460

gagacagcct atggcgttct ggaaggcccc gacaagaagg gcagattcct gaccagaaag     2520

cggatcaccg atcctgccaa gggcgttgtc ggatcttggg aacagcctaa gtggcgggac     2580

gtgatcccac tgtatagaag aggcgagggc cctgacagca cactgcctta caaggcctac     2640

atcggcggca gcaactactg catcgaaatt gtgcggacag ccaaaggcaa gtgggctggc     2700

gaagtggtgt ctacccatac agccaacaca gccgagtacc gggcctttat ggctgagcct     2760

ggtgcctaca gagcccagtc ttatgctggc ggcgatctcg tgatgaggct gatcgccaac     2820

gacacaatcg ccatcgaagt gggagatgct ggccggcaga tcatgagact gtgtcagctg     2880

gaaaccgtgg gagccatgta cttcgccaac gttcgcgagg gaaacgtggc cgcaagaagc     2940

agagccaggg acaacgattt cagtctgctg aagaaggccg cctccacact gcagccactg     3000

aaggctagaa gagtgtttgt ggaccccatc ggcagagtgt tcgatcccga cttcaaagag     3060


<210>  19
<211>  3135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 DNA optimized for expression in human cells

<400>  19
aactacatcc tgggcctcga tctgggatct gcctctcttg gatgggccgt gctggaatgt       60

accgaggttg acggaagcct gcagcctacc agaatcgaaa gaaccggcgt gcggatcttt      120

gaagccggcg tggaaggcga tatcgagcag ggaagagatg cctctagagc cgccaagaga      180

agagaggcca gacagcccag acggcagaat tggagaaccc agcagcggaa gcggaagctg      240

tttagactgc tgcaacagca cggactgctg cccgcctctg agaaggatga tgccatcagc      300

agaaaggccg tgttcgacca gctggacaaa gagctgaccg agaagcacat caccgagggc      360

gatcacacag cccaccagca tctgccttac ctgctgagaa tgctggcctc cggcgccaaa      420

gtgaagcctt ttgaactggg cagagccatc tacagcctgg ctcagagaag aggcttcctg      480

agcaatagga aggccgacac cgacgagaaa gaggatggcg tcgtcaaggc ctctatcagc      540

gaactcggag gacagatcgc cggcagaaca atcgcccaga ccttcgtgga agatatcagc      600

cccgatcacg aggaccccgg cagacagaga atcagacaga ggtacaccgc cagagagatg      660

ttccacgacg agttcaaccg gatcagaaag cagcagcagc cccacttcga cctggccgac      720

aatgattggg acaccgtgta caagaccatc ttcttccagc ggcctctgaa gtcccagcgg      780

cacagaatcg gaagatgcga gatcgatggc ggccagagat gtctggatgc cctggatgtg      840

ttccagcagt tcagaatctg gcacgccgtg cagaacctga gactggccga tgcctattct      900

ctggggagag atggcagact gaccctggaa gaacagcaga aaatcgtgga cgccctgcag      960

acccaggcca ccatgacatg gggaaaagtg gttaccctgc tgggcctgaa gcggggcacc     1020

aagtttacaa tccaagagtg gaacaccaag ggcctgaccg gccacagaac aaactctgcc     1080

atgatgcacg tgttcggcga cgagtggctg gacagacctc tggaagagag ggacgccatc     1140

accaaagaag tggtgtactt cagaaagccc agcgccatga gaaagcgggg acaagaagct     1200

tggggcctgt ctgaagaaca ggccgctctg ctgcctagca ccagacttga agaagcccac     1260

gccagacatt ctgctgccac actggccatc tttgtggaac ggatgagcag aggcgaggac     1320

tacagcacca tcagaaagga catcaccggc aaggacgaca gcgagcctct tgatcaactg     1380

cctcctctga gcaaggccgg actggatatc accaatcctg ccgtgatcag aggcctgaca     1440

gagctgagaa aggtggtcaa cgaactcgtg cggcagtacg gcaagcctat cggaatcaga     1500

atcgagctga gcagaagcct gaagaactcc cgggacaagc ggatcaagct gcacaaggac     1560

aacgaggacc gcagaaagcg gagagagaag gccatcgagg gaatcctgaa gcagatccct     1620

ggcagataca gcggcaacga catcgagaaa tggctgctgg ccgaggaatg tggctggcac     1680

tgtccttata ccggcagacc tatcagccct agcacactgc tgggcagcca gcctcagttt     1740

gacatcgagc acatcttccc tcggcgctac ctggacaaca gcttcagcaa caagaccctg     1800

tgctaccacg agtttaatcg gaacgtgaag aagaaccaga ccgccttcga tgcctgtagc     1860

ggcctggatt cttgggacga gatcctgcag agagtgaaca acttcgacgg acccgtggct     1920

gccctgaaga gaaagagatt tctgaccgcc gccaaagaga tccccgacgg ctttaccagc     1980

aagcacctga acgacaaccg gtacaacgcc gtggtggcca agaaatacgt ggccatgctg     2040

tatggcggcc tgtccgatgc tgatggatct cagagagtgt ttgccgtcac cggcggacat     2100

acagcactgc ttagaagaga gtggggcctg aacagcatcc tgagcggcac cgaagagaaa     2160

accagggacg atcacagaca ccacgccgtg gatgccgtgg ttattgccct gacagatcct     2220

gccaggattc aggccctggt taatgccgcc gagctggccg aaaagaaggc cagcagacgg     2280

ttttatgagg ccgtgcagga cccctggcct aagtttagct ctaaggtggc cgacagcatc     2340

aacgagattg tggtgtccca ccggcctaca agaacactgc ctggtgctct gcacgccgag     2400

agcatctact ccaagcctca catcgacaag gacggcaaca ccaaccacag gattcggaag     2460

cacattacca agctgtccgc caccgagctg aagaaagaca agatcgtgga ccccgccatc     2520

agggacctcg tgaaggccaa actgaaagag ctgggcgaga gcaaccctgc caaggccttt     2580

gccgaggaaa agaatcaccc atttctgaca gccaaggatg gccggaagat ccccattcac     2640

aaagtgcggg tgttcgccga taagaagcct cgggccattg ccaagaacga gcggcagaga     2700

tatgtggcca gcggcaagga tagcaacttc gccagcatga tctacgctgt ggtggataag     2760

gacggccacg agatcaagtg ggagcacaaa gtgatcaccc ggctggaagc ccatgagaga     2820

aagacccgga acagaaccgt gaacggcgag aaggtgctgc tgcctgatcc taccgacttc     2880

aacgacgaca agaaacgggt gttcaagttc gccctgtgca agaacgacac cgtgatgctg     2940

gaaggcccag atggcgacga cgtgatctgc agaatccaga agatcagcca ggccgagatc     3000

cagctgtgtc ctctggctac acctagcgtg cagggcaaag ccagatccaa gtggaaccag     3060

atccagagca tcgacaacct gcggaagtgg aatctgcgga ccgtgctgat ctctcccacc     3120

ggaattgagc acaga                                                      3135


<210>  20
<211>  3105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-76 DNA optimized for expression in human cells

<400>  20
ctgcacaaga tgagatacag actggccctg gatctgggca gcacatctct cggatgggcc       60

atgatcagac tggacgccaa tcagaggcct tgcgccgtga ttaaggccgg cgtgcggatc      120

ttcagcaacg gcagaaatcc taaggacggc agcagcctgg ccgtgactag aagagaagcc      180

agagccatgc ggcggagaag agacagactg ctgaagcgga aggcccggat gatgagaacc      240

ctgatcgagt acggattctt cccagccgag gaagcccaga gaaaggccct ggaaacactg      300

aacccctaca agctgagagc cgacggcctg gataaggctc tgacaccagc cgagttcggc      360

agagtgctgt tccacatcaa ccagcggaga ggcttcaaga gcaacagaaa gaccgacaag      420

aaggacaccg actctggcgc cctgaaaacc gccatcagca agctgcgcga gatcctgaaa      480

acagagaact gcagaaccgt cggcgagtgg ctgcacaaaa gaaatcaggc cggccagaca      540

gtgcgggcca gatatagaca ggacaagacc atcaaggacg acggcaaggc caagatcgac      600

aagtactacg acctgtacat cgaccgcgcc atgatcgagc acgagttcaa tgagctgtgg      660

cggaagcagg ccgagttcaa ccctgctctg tttagcagcg ccgcctacac cgatctgaag      720

gacgttctgc tgtaccagcg gcctctgaag cctgtgaagc ccggcagatg taccttcatg      780

agcgacgagg aaagagcccc tctggctctg cctagcacac agcggttccg gatgtaccaa      840

gaagtgaaca acctgagaat cctgcgcgag ggactgaaag aggaacccct gacactgcag      900

cagagggacg atctgatcgt ggtgctggaa cggaacaaca agcggacctt cacacagatc      960

aagaagctgc tcggagttgg cggagccgtg cagttcaatt tcgaggaccc caagagagag     1020

gaactgaagg gcaacaccac caacgccatc ctgggcaaga aagagcactt tggagaggcc     1080

tggatcgcct tcgatgaggc caaacaggat gccatcgtga tgcagctgat caaagaggaa     1140

aacgaggcca agctgatcca gtggctccag gacgagacag gcattgagga agagagagcc     1200

gagatcattg ccaacgtggg cctgcctgaa ggctatggct ctctgggaac aaaggctctg     1260

gccaggattc tgcccgagct gagaagagat gtggtcacct acgataaggc cgtgcaggct     1320

gccggatttg agcaccactc caagctgaat cagaaccggg gcatccccgg catcaccttc     1380

aagatcgaga gcatcgatca ggacaccggc gaaatcaaag agtttcacat ccacaaagag     1440

ctgccctact acggcgagta cctgcagaga cacgttggct ttggcagcgg aaagcctgag     1500

gaccctatcg agaaaagata cggcaagatc gccaatccta ccgtgcacat cggcctgaat     1560

caagtgcggc tggctgtgaa cgccctgatc aagagatacg gacaccccag cgaagtgatc     1620

gtggaagtgg ccagagatct gaagcagagc aaagagcagc ggagcgaaga gaacaagaga     1680

caggccgaga accagcagcg gaacaatcgg ctgagaaccg agattgcccg catcctgcag     1740

atcaacgagg aaggcatcag acgggacgac atcgagaaga tgatcctgtg gatcgagctg     1800

agcgccgatg tggccgatag aaagtgtcct tacagcggcg tgccaatcag cgccaccatg     1860

ctgctgtctg acgaggtgga aatcgagcac atcctgcctt tcagccagac actggacgac     1920

agcctgaaca acaaaacagt ggccctgaga aaagccaaca gagtgaaggg cgacagaacc     1980

ccttgggaag ctcagcagga ttttgccgct caaggctggt cctacgccga cattctggct     2040

cgggccgaga atatgcggaa agagaagcgg tacagattcg ccgaggacgg ctacaagaga     2100

tggctgaagg atgacgccgg cttcctgcct agagcactga acgataccag atacctgagc     2160

agagtggccc gggaatacct gcacctgatc tgccccaata ccagagtgat ccctggcaga     2220

atcaccgcca tgctgagatc ccagttcgga ctgaacaagg tgctgggcct gaacggcgag     2280

aagaaccgga atgatcacag acaccacgcc gtggatgcct gtgtgatcgg agttacagat     2340

cagggcctgc tgcagaagtt tgccaaggct tctgccagcg ccagagagaa gcagctgaac     2400

agactggtgg acaacatgga aagcccttgg aagaactacc aagagcacgt gcagagggcc     2460

atcgatgcca tctgggtgtc ccacaagcct gatcattctc acgagggcgc catgcacaat     2520

gataccgcct atggcctgag aggcaacggc aaggtgtcct ttcacaaaat gatggacggc     2580

aaacgcgagt acatcgagga caacctgaaa gtgatcgaga tcgccgatac caaggccgcc     2640

gaaagacacg gactgctgcc taatggcaag cccaagcctt acaagggcta caaaggcgac     2700

agcaactact gcatcgagat tgtgcggaac gagaaaggca gatgggaggg cgaagtcatc     2760

agcacctttg aggcctacca gctcgttaga gaacagggcg ctgcacagct gagacaccca     2820

gctctgggaa tctctggcaa gcctctggtc atgcggctga tgatcgatga caccgtcagg     2880

ctggatgtgg acggccagag ctgtaccatg agaatcgcca agctgtcctc caacggccag     2940

atcttcatgg ccgacatctg cgaggccaat gtggacgccc ggaacagaaa caaagaggac     3000

tccttcgcct acatctccaa gatggccggc tctctgcaga ccgccaaggc cagaagagtg     3060

acaatctctc ccatcggaga gctgagagac agcggcttca aaggc                     3105


<210>  21
<211>  3183
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79 DNA optimized for expression in human cells

<400>  21
gagaagagac tgggcctcga catcggcaca aatagcatcg gctggtgcct gtacgagggc       60

gactctatcc tggatatcgg cgtgcggatc ttcagcgacg gcagagatcc taaatctggc      120

gcctctctgg ccgtggacag acggaatgct agagccatgc ggcggagaag ggatagatac      180

ctgggaagaa gaagcgccct gatcaaggcc ctgaaggccc atggactgtt tccagccgaa      240

caggatgccg ccaaggctct ggaaagagag gacccttaca gcctgagagt cagagccctg      300

gatcacagac tggaccctca tcagatcggc agagccatct tccacctgaa ccagcggaga      360

ggcttcagaa gcaacagaaa ggccgacaga gtgctgggcg atcaagagag cggactgatc      420

agcacagcca ccagagttct ggacgaagcc atggccaaaa gcggcgctag aacactggga      480

gagtttctgg ccagccggga cactagaaga gtgcggatga ggcctgacgt gaagggctac      540

gacttctacc ccaaccggca gcactacctg gaagagttcg agaagatctg ggacgcccag      600

agccagtatc accctgatct gctgtctcag caggccaaga gcgccatcca ccggatcatt      660

tttcaccaga ggccactgaa gccacaggcc gtgggaacat gtacatttgc cggactgcat      720

ggcatccccg gcgacgagac aagactgcct aaagctcacc ctctgttcca gcagcggcgg      780

ctgtatgagg aagtgaacca gctggaaatc gtgtgcgcca gcgctcctgc cagaaagctg      840

accagagatg agagagatgc cctgatcctg aagctgcagg acaagaaaaa agtgaccttc      900

agcacactgg cccggaccat cagactgaaa gagggcgaga gattcaacaa agagagcgag      960

aaccggaagg acctggctgg ggatgaagtg cgggccgaga tgagcgataa gaccagattc     1020

ggcagacggt ggtttcacct gagcctggat gagcagtggt ccgtgatcga cagactgctg     1080

aacgaggaaa gcaccgagga tctgctggcc tggctggaaa aagagtggtc cctgccttct     1140

gatgtggccg aagccgtggc taatgcccat ctgcctgatg gccacggaag atttggcctg     1200

acagccaccg ttagactgct cgaacacctg aaagccgacg tggtcacata tgccgaagct     1260

gctcggagag ccggcttcca ccactctgat ttcagagatg gcgcctgcta cgacgagctg     1320

ccttactatg gcgagatcct gagcagagag atcgcccctg gaaaggacga gtacggcgat     1380

ccactggaaa gacagtgggg caagatcaca aaccccaccg tgcacatcgg cctgaatcag     1440

ctgagaaggc tgattaacgc cctcgtgcgg agacacggca gacccgattt catcttcgtg     1500

gaactggccc gcgagctgaa gctgaatgag aagcagaagg ccgaccacaa gcggcggatc     1560

aagcagacaa cagatgccgc tagagctaga gccgagaagc tgagagaaat cggacagaga     1620

gacagcggct ccaaccggat gctgctgcgg atttgggaag aactgaaccc cagcaatccc     1680

ctggacagaa gatgccctta ttgcgccgag cctatctcca tcgagatgct gatgagcggc     1740

agcgccgaca tcgatcacat cgtgccttac agcagatgcc tggacgatag cgccgccaac     1800

aaagtggtgg cccacaacca ctgcaacaga cagaagggca acagaacccc ttgggagcag     1860

tggggacaga ccacaagatg gcccctgatt caagaacagg tggcccggat gcacagatcc     1920

aaacaatggc gcttcggccc cgacgccatg gaacgagttg atcgagatgg cggctttatc     1980

gcccggcagc tgacagatac ccagtacctg tctagaatcg ccgcacagta cctgagcgcc     2040

ctgtacacac ctgatgaagg cagacgggtg tacgccgtga caggcagact gactgctatg     2100

cttagacggc tgtggggcct gaacgacatc ctgcctgatc acaactgggt gctgaaccct     2160

cacagcaacg cccctaagaa caggctggat catagacacc acgccatcga tgccgccgtt     2220

gtgggagcta caacacccgc catgattcag caggttgcca gagctgctgc aagagccgag     2280

gaacaggacc tggatagact gttcgctgac ctgcctcctc catggccagg ctttagagag     2340

gaactgcagg gcagaattat ggccgctgtg gtgtctcaca agcccgacca tggaagaaag     2400

ggcagaccac tgcctggcag agatagcaca tccggcagac tgcacaatga caccgcctac     2460

ggctttactg gccgcagaaa tgccaagggc atgcctatcg tggtcaccag aaaacccctg     2520

ctggccctga aacctgagga cctgacagac cccgagagaa tcccagatcc tgctctgcag     2580

ggcgcactgt ttgaagccac tagaggcgct accggcaagg acttcgagaa agccctgcgg     2640

gacttcagca gaagagatgg cccttaccag ggcatcagac ggattagact gaccgaggct     2700

ctgaacgtga tccccatcag agatagaacc ggccacgcct acaaaggcgt gaaaggcgac     2760

gccaacgcca gattcgatgt ttggagactg cccgacggca agtggatcac cagatggaag     2820

gatagagatg gcatcgagca cagcggcatc gtgtccctgt ttgatgctca ccagcctagc     2880

caggtgtacc acagacctca tcctgccgcc aaaaaggtgc tgagcctgag acagaatgac     2940

ctggtggcag tggaacacga tggcgacccc ggaaagatca tgcgggtcgt gaagtttagc     3000

gccaacggca gcatcacatt cgccccacat aatgaggccg gacctctgaa aacccgggac     3060

accgatcctg ccgatccttt cagatacgtg acaacagtgg ccagcggcct gaagaagatg     3120

agagccagac aagtgcggat cgatgagctg ggcaaagtgc acgatcccgg acctagagag     3180

gat                                                                   3183


<210>  22
<211>  3222
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-80 DNA optimized for expression in human cells

<400>  22
accaccacac tgggcatcga tctgggcaca tcttctctcg gctggtgcct gatcgaggac       60

gagcacagaa tcctggacct gggcgtgatc attttttctg ccgctgccgg cgctggaaga      120

gatcctcaat ctggtgctcc tctggccgag gccagaagag aagccagaag cgctcggcgg      180

agaagagaca gattcatcgg cagaagaagc gccctgctgg acaagctgat tgctctggga      240

cttctgcctg gcgatccacc agctggacac ggaagaagaa gaaatcaggc cctgcctaac      300

gccgagacaa aggcccttgc cgatacagat ccccacgtgc tgagaagaag ggctctgtct      360

gaacctctga gccctcacga gatcggcaga gccatcttcc acctgaacac cagacggggc      420

ttcaagagca acagaaaggc cgacagaggc cggaatgagc ccgagacagg caaaattgct      480

acagccggac aggccctgga tgccgctctg ggaaaaagaa cactgggcca gtttctggcc      540

gatcggattg atgctggaca gcctgccaga gttagaatgg gcggcgagaa tcaggcctac      600

gacttctatc ctcagcggag ccacctggaa gccgagtttg ctgccatttg ggaagcccaa      660

gagcaccacc atcctgagct gctgaccgat acagccagaa ccgccatcca ccgcatcctg      720

ttcttccaga ggccactgaa aacccctgaa gtgggcttct gcacctttgc cggaatgtct      780

ggcgtgcccc atgatgagag aaggctgcct aaggctcacc ctctgttcca agagcggaga      840

ctgtacgagg aagtgaacaa cctgaaagtg gtggccgctg gcgctgccgc tagagatctt      900

acactggacg agcgggacag actgatcctg aagctgcggg acaacaagaa agtgaccttc      960

gccacactgg ccaagaaggt gctgaagctg gccgaaggcg agcggttcaa caaagagagc     1020

gaggctagaa aggacctggc tggggatgaa gtgcgggccg aaatggccga taagaagaga     1080

ttcggcaacc ggtggaccca ctttccactc gagagacagc tgcagatcat cgaccgggtg     1140

cagaacgagg aaaaccccga tattctgctg gcctggctgc agagcgattg cggacttgat     1200

aaggctgctg ctgtggccgt ggccaggaca aatcttcctg aaggccacgg cagattcggc     1260

gagacagcca caagaaggct gatcgccgct ctgaaggccg aggtggtcac atatgataag     1320

gccgcactgg ctgccggctt ccaccactct gatcatagaa ccggcgaggt gtacgacctg     1380

ctgccttatt atggcgaggt gctgaccaga gagatcgccc ctggaaaagc cgagtatggc     1440

gaccctctgg aacggcagta cggcaaagtg accaatccta ccgtgcacat cggcctgagg     1500

cagctccaga aactcgtgaa tgccgtgatc gccagacacg gcagacccga cagaattgtg     1560

attgagctgg cccgggaact gaagctgaac gacaagcaga aagacgagca ccagcggcgg     1620

atcagaagag ataccgaggc cgccattaga cggggcgaga aactggttga agccggaatt     1680

gctgacaccg gcgccaatag agcactgatg agacagtggg aagaactgaa ccccagcaat     1740

cccctggaca gaagatgtcc ttactgcggc gagcctatcg gcatggccca gatctttaac     1800

agcctggccg acatcgacca catcatccct tacagcagaa gcctggacga cagccccgct     1860

aacaaagtgc tggtgcaccg gaactgcaac cggcagaagg gaaacaagac cccttgggac     1920

agatggcacg aggatgaggc caagtgggag atcatttctg cccaggtggc cagaatgcac     1980

cctagcaaac aatggcgctt cggccccgat gccatggaaa gacttgagag agatggcggc     2040

tttgccgcca gacagctgac cgacacacag tacctggctc ggatcgccga caagtacctg     2100

agaggactgt accctacagc cgacgagggc agagtggatg tgatccctgg aagaatgacc     2160

gccatgctgc gaagagtgtg gggcctcaat tctctgctgc ccgaccacaa cttcgtggaa     2220

aacgagcact ctagcgcccc taagaaccgg ctggatcaca gacaccacgc cattgatgct     2280

acagtggccg ccgtgacaag cctgagcaga atgcaacaga ttgccgccgc agccgccaga     2340

tccgaggaaa aagagctgga aaggctgttc gacgatctgc cccatccttg ggacggcttt     2400

agagaggatc tgggcgcctg tctggctaga acagtggcca cacacaagcc cgatcacgga     2460

agatctgcca agccaagcag acacagagat gtgacagccg gcaagctgca caatgatacc     2520

gcctatggcc tgaccggcct gaaaaccacc gatggcaaga cacccatcgt ggtgcataga     2580

gtgctgctgg cttccctgaa gcctacacag atcgccgatc ctgactgcat ccccgacgag     2640

acactgagaa atgccctgtg gctggccaca agagattgca gcggcaaggc ttttgaccag     2700

gcactggcca gattcgccaa agaacacccc gtgttcaagg gcattagaag agtgcggatc     2760

agggaaccac tgaacgtgat ccccatccac gacagagagg gcaagcccta caaaagctac     2820

gctggcgcct ccaacgacag atacaatgtg tggcggatgc ccgacgcctc ttggagacac     2880

gatgtcgtgt ccaccttcaa cgcccacaga agcgactaca gagatctgag gccacatcct     2940

gccgccaaaa aagtgctgtc cctgcggcag aacgacatga tcgccgtgga aagaaacggc     3000

ggcctgcgcg agatcatgcg ggtcgtgaag tttaatcagg ccggcagact gaccctgtgt     3060

cctcctaatg aaggcggaaa gctgcagaac agggacgccg ctccaaacga cgccgatcca     3120

ttcaagtaca cctatctgag ccccagcagc ctgaagaacg ccaaagccag acaagtgcgc     3180

atcgacccac tgggaagagt gttcgatccc ggacctagag ag                        3222


<210>  23
<211>  3132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-81 DNA optimized for expression in human cells

<400>  23
aagaacaaga tgcagtaccg gctggccctg gatctgggca caacatctct tggatgggcc       60

atgctgagag tgaagcccaa tcctgagggc agactggaac cttttgccgt ggttaaggcc      120

ggcgtgcgga tcttctctga cggcagaaat cctaaggacg gcagcagcct ggccgtgact      180

agaagagaag ccagagccat gcggcggaga agagacagac tgctgaagcg gaaagcccgg      240

atgctgcaac agctgaccgc cttcggcttc tttcctaccg atctggccga gcggaaggcc      300

ctggaaacac tgaatcctta cgagctgaga gccaaaggcc tggacgagcc tctgagccct      360

tacgagtttg gcagaagcct gttccacatc aaccagcgga gaggcttcaa gagcaaccgc      420

aagaccgaca agaaagagaa cgacagctct gccctgaagg ccgccattag aagagtggcc      480

agcgagatcg atggcaacca ggccagaaca gtcggcgagt ggctgtacaa gagaatgctg      540

aacggccagc ctgtgcgggg cagatacaga gaaacaaagg tgcagaaaga ggacggcaag      600

accaagatcg acaagtccta cgacctgtac atcgatagag ccatggtgga agccgagttt      660

gaggccctgt gggctaagca ggcttctctg aatcctgccg tgtacagcga gcaggccaag      720

gccacactga aggatgtgct gctgttccag agaaacctgc ggcctgtgaa gcctggcaga      780

tgcacactga tccccacaga ggaaagagcc cctctggctc tgcctagcac acagcggttc      840

cggatctacc aagaagtgaa caacctgaga atcctgagag agggcctgaa ggacgaagcc      900

ctgacactgg ttcagagaga tgccctggtt acagccctgg aacagaacaa caagcggaca      960

ttcgcccaga tcaagaagct gctgggactc gacggccaga cacagttcaa cttcgaggac     1020

cccaagcggc aagagctgaa gggcaatacc acaagcgcca tcctgtctca ccctaagcac     1080

ttcggcgacg cttggtttgg cttcgacgag gccaagcagg atggcatcgt gtgccagctg     1140

ctgaacgagg aaaatgagag cgccctgatc cggtggctga tggatcatac aggcgtggac     1200

gaagctcacg ccgaggctat tgctaatgcc gctctgccag aaggctacgg ctctctgtct     1260

agagctgccc tggccaagat tctgcctgag ctgagaaagg ccgtgatcac ctacgataag     1320

gctgcccagg ccgctggctt tgatcaccac tctcacatca gccctagcac cacaggcgag     1380

atcctgccag agctgcctta ttatggcgag gccctgcaga gacacgttgg ctttggaacc     1440

ggcaatcccg acgatgtgcc tgagaagaga tacggcaaga tcgccaatcc aaccgtgcac     1500

atcggcctga atcaagtgcg gaaggtggtc aatgccctga tcaagagata tggacacccc     1560

agcgaagtga tcgtggaagt ggccagagat ctgaagcaga gcaagaagca gcgcgacgaa     1620

gagaacaaga gacaggccga gaaccagaag cggaacgagc ggatcagaca ggatattgcc     1680

gccatgaggc ccgacagatc cgaagagaga gtgacccgga ccgacatcca gaaatggatt     1740

ctgtgggaag aactgagctt cgaccccgcc aacagatgct gtccttactc tggcgtgcag     1800

atcagcgccg agatgctgat gtctgacgcc gtggaaatcg agcacattct gcctttcagc     1860

agaaccctgg acgacagcct gaacaacaaa accgtgtcca tgaggcaggc caatcggatc     1920

aagggcaatc agaccccttt cgaggccttc ggcaaggata acgccctggg cgtgaactac     1980

agcgacatcc tgatgagagc ccagcagatg cccaaggcca agagaaagag attcgccgag     2040

aacgccctcg aggaatggct gcagaacgag aagaacttcc tggctagagc cctgaacgac     2100

accagatacc tttccagagt ggcccgggaa tacgtgtccc tgatctgtcc tcaagccacc     2160

agagtgatcc ctggccagat gacagcacag ctgagggcca agtttggcct gaacgatatc     2220

ctcggcctgg atggcgagaa gaatcggaac gatcacagac accatgccgt ggatgcctgt     2280

gtgatcggag tgacagatca aggcctgctg cagagatttg cctacgcctc tgccagcgcc     2340

agagctaatg gactggctag actggtggac acaatgcccg atccttggcc tagctacaga     2400

cagcacgtgc agagggccgt gcagaacatc tatgtgtccc acaagcctga ccacagccac     2460

gagggcgcca tgttcgatga gacaatctac agcgccaccg gcaagtctag aagcgccgcc     2520

aaggatagaa cagtgatccc ctttatcgcc aagaactggt cacaccccga cgaccacaac     2580

aagcagaggc cttttaaggg cctgatcacc gacgtgtccc agagacacca gaacaagcct     2640

tacaagggcc tgctgagcaa cagcaactac tgcatcgaga tctactccga tgaggccgga     2700

tggggcggac acgtgctgaa aacattcgac gcctatcaga tcgtgcgggc ccacaagaat     2760

gcctctgagg gaatgcaggc cctgcggaac aagcacagca gccagaatgg ccatcctctg     2820

gtcatgagac tgatgatcgg cgactacatc cgggccgaga ttgatggctt tctgctgctg     2880

ctccaagtgc tgaagatcaa cagcagcggc agcatcacct tcatcaagcc caacgagaca     2940

aacatcagcg cccggtatct ggccaagctg gctgctcaga aagcccagaa agaaggcaag     3000

cccttcgacg atatcgccct gaatgacgtg ttctttcaga aggccatctc cgccgatagc     3060

ctgcggctgt ttaaagccag acctgtgaca ctgagcccca tcggcgaact gagagatccc     3120

ggctttaaag gc                                                         3132


<210>  24
<211>  3210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 DNA optimized for expression in human cells

<400>  24
agactgggcc tcgatatcgg caccaattct atcggctggt ggctgtacag aaccgagaac       60

gaccagatca cctgtgtggt ggatggcgga gtgcgggtgt tctctgatgg cagagatccc      120

cagagcaaag aaagcctggc cgtggacaga agagtggcta gagcccagcg gcggagaaga      180

gacagatacc tgagaagaaa ggccgctctg atgaagagaa tggccgaggc tggactgatg      240

cctgctgatc ctgttcaggc caaagctctg caggctctgg acccctatga tctgagagcc      300

agaggactgg atgaagccct gccactggct catttcggca gagccctgtt ccacctgaac      360

cagagaagag gcttcaagag caaccggaag gccgacagag gcgacaatga gagcggaaag      420

atcaaggacg ccaccgccag actggactgg gccatgagag atgccagagc cagaacctac      480

ggcgagttcc tgcacatgag acaggacaag gccgacgatc ctagaagagt gcctaccgtg      540

cggaccagac tgtctgtggc cagaagagat aacgccgaga aagaggaagc cggctacgac      600

ttctaccccg acagaaggca cctgagcgaa gagtttgatg ccctgtgggc cgctcaggcc      660

gaacaccata caaccctgac cgacgacctg cgggatcaga tcaagaccat catcttccac      720

cagcggcctc tgaaggctcc tgaagtgggc ctgtgtctgt tcaccgacga gagaagaatc      780

cccagcgctc accctctgaa ccagcggaga atcctgctgg aaaccgtgaa cggcctgaga      840

atcgtggcaa gaggcgaagc cgctagaggc ctgacaagag aggaacgcga tcagatcgtg      900

cacggcctgg ataacaaggg ccacacaaag acactgagcg gcatgagcat gaagctgcgc      960

gccatcggca aagtgatcaa gctgagatcc gaccagagct tcaccctgga aacagccaac     1020

agggacgcca ttgcttgcga tcctgtcaga gcctctctgt ctcaccctga gagaatgggc     1080

ggagtgtgga caacactgga tgaggatgcc cagtgggacg tcgtgcagag actgagagct     1140

gtgcagagcg atacagagca cgaagccctg gtggattggc tgatggccac acacggactc     1200

ggacaggatt atgcccaggc cacagctaat gcccctctgc ctgaaggata tggcagactg     1260

ggactgaccg ccaccagaaa gattctggct gccctggaag ccgacgtgat gagctattct     1320

gatgccgtgg ctgcctgtgg atggtcccat tctggtggac ctacaggcga agtgctggaa     1380

gctctgccct actatggcga gatcctggac agacacgtga tccctggcac cggcgtgaaa     1440

accgacgagg atgtgaagag attcggccgg atcacaaacc ccacagtgca catcggactg     1500

aatcagatcc ggcggctggt caacagaatc atctgtgtgc acggcaagcc tgaccagatc     1560

gtggtggaag tggccaggga cctgaagaac agcgaggatc agaagagaga gatccagaaa     1620

accatccgga agaacaccga cgacgccatc aagagaggca agaagctggt tgaggaactg     1680

ggccagaagg acaccggcgc caatagactg attctgcggc tgtgggagaa cctgggcaac     1740

gatgtgatga ccagacagtg cccctacagc ggcaagagaa ttagcgccgc catgctgttc     1800

gacggcagct gtgatgtgga ccacattctg cccttcagca gaaccctgga cgacagcatc     1860

tggaacaaga ccctgtgcct gaaagaagag aatcgcaaga aggccaacaa gacaccctgg     1920

gaagtgtggg gcgagacaga ccagtgggat gtgatcgtgg ccaatctgaa gaacctggac     1980

cggaagcagg cttggagatt tgcccctgac gccgtggaaa gattcgaggg cgagaacgat     2040

ttcagcgctc gggccctgaa agacacccag tacctgtcta gagtggctcg ggcctatctg     2100

gacgctctgt atgatggcgc cgatggcaag tctcacgtgt gggttgtgcc aggcagactg     2160

accgaaatgc tgagaaggca ctggggcctg aatggcatcg aggtgctgac agactctgac     2220

gcccagaccg tgaagtccaa gaacagacag gaccacagac accacgccat tgatgctgct     2280

gtggtggccg ctaccgatcg gagcctgatc cagaggatct ccaagatcgc caagcacgat     2340

gaacaggctg gcgccgaaca ggtggcaaga tctgttcctc ctccttggga cggcttcaga     2400

gatgatgtgg ccggacagat cggcaggatc attgtgtctc acagagccga ccacggcaga     2460

atcgatccta cagccagagc acagggcagc gatacaacag ccggacagct gcacatggat     2520

accgcctatg gaattgtgga cggcggccac gtcgtgtcca gaaagcctct tatgtctctc     2580

ggagccggcg acatcagaaa gatcagagat cctgacctgc agcggcatct gaccagagtg     2640

acacgcggac tggacaagaa agagttcgaa caggccctgg cctccttcgc cgcttctaga     2700

aaactgcccg atcagagcga gaacccctac ttcggactgc ggagagttag actgctggac     2760

gcactgcagg atagcgccag agtgcctgtt agaaacgcca ccggcaacat ctacaaggcc     2820

tataaggccg gcagcaacca ctgctacgaa gtgtggcgga tgcccgacgg aaaagtgaag     2880

ccttgggcca tctctacctt tgaggcccac cagagcggag atggctctaa acctcatcct     2940

gccgccaagc ggctgctgag agtgttcaag cgcgatatgg tggtcatcga gcggaagggc     3000

atcaccgtga tctgctacgt gcagaaaatg gacgtggcca acggcctgtt tctggtgcct     3060

cacacagagg gcaacgccga cgccagaaat agggacaaag aggacgactt caagttcatc     3120

cagatgagcg ccgcctctct gatcaaggcc agaattagaa gggtgcacgt ggacgagatg     3180

ggaagaatga gagatcccgg acctcctcgg                                      3210


<210>  25
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-59 crRNA (Repeat)

<400>  25
guuccgguca                                                              10


<210>  26
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-59 tracrRNA (Antirepeat)

<400>  26
uggucgcuaa c                                                            11


<210>  27
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-59 TracrRNA Portion 1

<400>  27
aagcugaugc uuuuguagcu agaugcaaaa aaug                                   34


<210>  28
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-59 TracrRNA Portion 2

<400>  28
gaaagccggg caugcccggc uuucggcuuu u                                      31


<210>  29
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-59 sgRNA Scaffold V1

<400>  29
guuccgguca gaaauggucg cuaacaagcu gaugcuuuug uagcuagaug caaaaaaugg       60

aaagccgggc augcccggcu uucggcuuuu                                        90


<210>  30
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-61 crRNA (Repeat)

<400>  30
guugcggcca gagcu                                                        15


<210>  31
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-61 Partial crRNA 2

<400>  31
guugcggcca ga                                                           12


<210>  32
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-61 Partial crRNA 3

<400>  32
guugcggcca                                                              10


<210>  33
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-61 tracrRNA (Antirepeat)

<400>  33
ggcucugccg cuaac                                                        15


<210>  34
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-61 Partial tracrRNA 2

<400>  34
ucugccgcua ac                                                           12


<210>  35
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-61 Partial tracrRNA 3

<400>  35
ugccgcuaac                                                              10


<210>  36
<211>  35
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-61 TracrRNA Portion 1

<400>  36
aaggagaaac uuguuggauc aggacuccac aagau                                  35


<210>  37
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-61 tracrRNA Portion 1-partial

<400>  37
aaggagaaac uuguu                                                        15


<210>  38
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-61 TracrRNA Portion 2

<400>  38
gagacggcuc ccucgugggg ccguuuu                                           27


<210>  39
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-61 sgRNA Scaffold V1

<400>  39
guugcggcca gagcugaaag gcucugccgc uaacaaggag aaacuuguug gaucaggacu       60

ccacaagaug agacggcucc cucguggggc cguuuu                                 96


<210>  40
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 crRNA (Repeat)

<400>  40
gcugugguuc gucggg                                                       16


<210>  41
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 Partial crRNA 1

<400>  41
gcugugguuc gucgg                                                        15


<210>  42
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 Partial crRNA 2

<400>  42
gcugugguuc gu                                                           12


<210>  43
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 Partial crRNA 3

<400>  43
gcugugguuc                                                              10


<210>  44
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 tracrRNA (Antirepeat)

<400>  44
ccugacuuau cacagu                                                       16


<210>  45
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 Partial tracrRNA 1

<400>  45
cugacuuauc acagu                                                        15


<210>  46
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 Partial tracrRNA 2

<400>  46
acuuaucaca gu                                                           12


<210>  47
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 Partial tracrRNA 3

<400>  47
uuaucacagu                                                              10


<210>  48
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 TracrRNA Portion 1

<400>  48
aagguucucu accgc                                                        15


<210>  49
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 tracrRNA Portion 1-partial

<400>  49
gguucucuac c                                                            11


<210>  50
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 TracrRNA Portion 2

<400>  50
acggcaaugu guuuacacau ccguu                                             25


<210>  51
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 TracrRNA Portion 3

<400>  51
aaggacgguc cuggaccguc cuuuuuuu                                          28


<210>  52
<211>  104
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-67 sgRNA Scaffold V1

<400>  52
gcugugguuc gucggggaaa ccugacuuau cacaguaagg uucucuaccg cacggcaaug       60

uguuuacaca uccguuaagg acgguccugg accguccuuu uuuu                       104


<210>  53
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-76 crRNA (Repeat)

<400>  53
guuccggcua gag                                                          13


<210>  54
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-76 Partial crRNA 2

<400>  54
guuccggcua ga                                                           12


<210>  55
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-76 Partial crRNA 3

<400>  55
guuccggcua                                                              10


<210>  56
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-76 tracrRNA (Antirepeat)

<400>  56
cucuggacgc uaac                                                         14


<210>  57
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-76 Partial tracrRNA 2

<400>  57
ucuggacgcu aac                                                          13


<210>  58
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-76 Partial tracrRNA 3

<400>  58
uggacgcuaa c                                                            11


<210>  59
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-76 TracrRNA Portion 1

<400>  59
aagcugaaag augcaccaaa ugau                                              24


<210>  60
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-76 tracrRNA Portion 1-partial

<400>  60
gcugaaagau gc                                                           12


<210>  61
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-76 TracrRNA Portion 2

<400>  61
agggucgcua uaggcgaccc uuuuu                                             25


<210>  62
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-76 sgRNA Scaffold V1

<400>  62
guuccggcua gaggaaacuc uggacgcuaa caagcugaaa gaugcaccaa augauagggu       60

cgcuauaggc gacccuuuuu                                                   80


<210>  63
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-1 crRNA (Repeat)

<400>  63
guugccgcug ga                                                           12


<210>  64
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-1 Partial crRNA 3

<400>  64
guugccgcug                                                              10


<210>  65
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-1 tracrRNA (Antirepeat)

<400>  65
uccaguuguu aac                                                          13


<210>  66
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-1 Partial tracrRNA 3

<400>  66
caguuguuaa c                                                            11


<210>  67
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-1 TracrRNA Portion 1

<400>  67
aagcagcuug acugcaccaa au                                                22


<210>  68
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-1 tracrRNA Portion 1-partial

<400>  68
gcagcuugac ugc                                                          13


<210>  69
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-1 TracrRNA Portion 2

<400>  69
aaggcggggg cugcggcccu cgcuuuuuu                                         29


<210>  70
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-1 sgRNA Scaffold V1

<400>  70
guugccgcug gagaaaucca guuguuaaca agcagcuuga cugcaccaaa uaaggcgggg       60

gcugcggccc ucgcuuuuuu                                                   80


<210>  71
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-2 crRNA (Repeat)

<400>  71
guugccgcug gaccg                                                        15


<210>  72
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-2 Partial crRNA 2

<400>  72
guugccgcug ga                                                           12


<210>  73
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-2 Partial crRNA 3

<400>  73
guugccgcug                                                              10


<210>  74
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-2 tracrRNA (Antirepeat)

<400>  74
cggucuggca guuaac                                                       16


<210>  75
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-2 Partial tracrRNA 2

<400>  75
ucuggcaguu aac                                                          13


<210>  76
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-2 Partial tracrRNA 3

<400>  76
uggcaguuaa c                                                            11


<210>  77
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-2 TracrRNA Portion 1

<400>  77
aagugucagu acgcaacaga u                                                 21


<210>  78
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-2 tracrRNA Portion 1-partial

<400>  78
gugucaguac gc                                                           12


<210>  79
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-2 TracrRNA Portion 2

<400>  79
aagggcgacg cuccggcguc gccuuuuuu                                         29


<210>  80
<211>  85
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-2 sgRNA Scaffold V1

<400>  80
guugccgcug gaccggaaac ggucuggcag uuaacaagug ucaguacgca acagauaagg       60

gcgacgcucc ggcgucgccu uuuuu                                             85


<210>  81
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-3 crRNA (Repeat)

<400>  81
guugccgcug gac                                                          13


<210>  82
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-3 Partial crRNA 2

<400>  82
guugccgcug ga                                                           12


<210>  83
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-3 Partial crRNA 3

<400>  83
guugccgcug                                                              10


<210>  84
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-3 tracrRNA (Antirepeat)

<400>  84
gucuggcggu uaac                                                         14


<210>  85
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-3 Partial tracrRNA 2

<400>  85
ucuggcgguu aac                                                          13


<210>  86
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-3 Partial tracrRNA 3

<400>  86
uggcgguuaa c                                                            11


<210>  87
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-3 TracrRNA Portion 1

<400>  87
aagcagccag ucugcaccag au                                                22


<210>  88
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-3 tracrRNA Portion 1-partial

<400>  88
gcagccaguc ugc                                                          13


<210>  89
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-3 TracrRNA Portion 2

<400>  89
aagggcggcg cuccggcgcc gccuuuuuu                                         29


<210>  90
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79-3 sgRNA Scaffold V1

<400>  90
guugccgcug gacgaaaguc uggcgguuaa caagcagcca gucugcacca gauaagggcg       60

gcgcuccggc gccgccuuuu uu                                                82


<210>  91
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-80 crRNA (Repeat)

<400>  91
guugcgguug g                                                            11


<210>  92
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-80 Partial crRNA 3

<400>  92
guugcgguug                                                              10


<210>  93
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-80 tracrRNA (Antirepeat)

<400>  93
cuggcuguua ac                                                           12


<210>  94
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-80 Partial tracrRNA 3

<400>  94
uggcuguuaa c                                                            11


<210>  95
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-80 TracrRNA Portion 1

<400>  95
aagcagcuug acugcaccaa au                                                22


<210>  96
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-80 tracrRNA Portion 1-partial

<400>  96
gcagcuugac ugc                                                          13


<210>  97
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-80 TracrRNA Portion 2

<400>  97
aagggcaggg cugcggcccu gccuuuu                                           27


<210>  98
<211>  76
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-80 sgRNA Scaffold V1

<400>  98
guugcgguug ggaaacuggc uguuaacaag cagcuugacu gcaccaaaua agggcagggc       60

ugcggcccug ccuuuu                                                       76


<210>  99
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-81 crRNA (Repeat)

<400>  99
guuccggcua gag                                                          13


<210>  100
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-81 Partial crRNA 2

<400>  100
guuccggcua ga                                                           12


<210>  101
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-81 Partial crRNA 3

<400>  101
guuccggcua                                                              10


<210>  102
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-81 tracrRNA (Antirepeat)

<400>  102
cucuagacgc uaac                                                         14


<210>  103
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-81 Partial tracrRNA 2

<400>  103
ucuagacgcu aac                                                          13


<210>  104
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-81 Partial tracrRNA 3

<400>  104
uagacgcuaa c                                                            11


<210>  105
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-81 TracrRNA Portion 1

<400>  105
aagcugaaag augcaccaaa ug                                                22


<210>  106
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-81 tracrRNA Portion 1-partial

<400>  106
gcugaaagau gc                                                           12


<210>  107
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-81 TracrRNA Portion 2

<400>  107
gaaagccgcu auaugcggcu uucgucuuuu                                        30


<210>  108
<211>  83
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-81 sgRNA Scaffold V1

<400>  108
guuccggcua gaggaaacuc uagacgcuaa caagcugaaa gaugcaccaa auggaaagcc       60

gcuauaugcg gcuuucgucu uuu                                               83


<210>  109
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 crRNA (Repeat)

<400>  109
guugcggcug gaccgc                                                       16


<210>  110
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 Partial crRNA 1

<400>  110
guugcggcug gaccg                                                        15


<210>  111
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 Partial crRNA 2

<400>  111
guugcggcug ga                                                           12


<210>  112
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 Partial crRNA 3

<400>  112
guugcggcug                                                              10


<210>  113
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 tracrRNA (Antirepeat)

<400>  113
gcggucgagc uguuaac                                                      17


<210>  114
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 Partial tracrRNA 1

<400>  114
cggucgagcu guuaac                                                       16


<210>  115
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 Partial tracrRNA 2

<400>  115
ucgagcuguu aac                                                          13


<210>  116
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 Partial tracrRNA 3

<400>  116
gagcuguuaa c                                                            11


<210>  117
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 TracrRNA Portion 1

<400>  117
aagcauucga uugcaccaca uu                                                22


<210>  118
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 tracrRNA Portion 1-partial

<400>  118
gcauucgauu gc                                                           12


<210>  119
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 TracrRNA Portion 2

<400>  119
gaagcgcagg gccacggccc ugcguuuu                                          28


<210>  120
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-82 sgRNA Scaffold V1

<400>  120
guugcggcug gaccgcgaaa gcggucgagc uguuaacaag cauucgauug caccacauug       60

aagcgcaggg ccacggcccu gcguuuu                                           87


<210>  121
<211>  6616
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pbNNC-3

<400>  121
gttgtgccac gcggttggga atgtaattca gctccgccat cgccgcttcc actttttccc       60

gcgttttcgc agaaacgtgg ctggcctggt tcaccacgcg ggaaacggtc tgataagaga      120

caccggcata ctctgcgaca tcgtataacg ttactggttt cacattcacc accctgaatt      180

gactctcttc cgggcgctat catgccatac cgcgaaaggt tttgcgccat tcgatggtgt      240

cgggatctcg acgctaaatt aatacgactc actatagggg aattgtgagc ggataacaat      300

tcccctgtag aaataatttt gtttaactaa agaggagaaa tttcatatgt acccatacga      360

tgtgccagat tacgctggca ccgagctcgg taccgagaag agactgggcc tcgacatcgg      420

cacaaatagc atcggctggt gcctgtacga gggcgactct atcctggata tcggcgtgcg      480

gatcttcagc gacggcagag atcctaaatc tggcgcctct ctggccgtgg acagacggaa      540

tgctagagcc atgcggcgga gaagggatag atacctggga agaagaagcg ccctgatcaa      600

ggccctgaag gcccatggac tgtttccagc cgaacaggat gccgccaagg ctctggaaag      660

agaggaccct tacagcctga gagtcagagc cctggatcac agactggacc ctcatcagat      720

cggcagagcc atcttccacc tgaaccagcg gagaggcttc agaagcaaca gaaaggccga      780

cagagtgctg ggcgatcaag agagcggact gatcagcaca gccaccagag ttctggacga      840

agccatggcc aaaagcggcg ctagaacact gggagagttt ctggccagcc gggacactag      900

aagagtgcgg atgaggcctg acgtgaaggg ctacgacttc taccccaacc ggcagcacta      960

cctggaagag ttcgagaaga tctgggacgc ccagagccag tatcaccctg atctgctgtc     1020

tcagcaggcc aagagcgcca tccaccggat catttttcac cagaggccac tgaagccaca     1080

ggccgtggga acatgtacat ttgccggact gcatggcatc cccggcgacg agacaagact     1140

gcctaaagct caccctctgt tccagcagcg gcggctgtat gaggaagtga accagctgga     1200

aatcgtgtgc gccagcgctc ctgccagaaa gctgaccaga gatgagagag atgccctgat     1260

cctgaagctg caggacaaga aaaaagtgac cttcagcaca ctggcccgga ccatcagact     1320

gaaagagggc gagagattca acaaagagag cgagaaccgg aaggacctgg ctggggatga     1380

agtgcgggcc gagatgagcg ataagaccag attcggcaga cggtggtttc acctgagcct     1440

ggatgagcag tggtccgtga tcgacagact gctgaacgag gaaagcaccg aggatctgct     1500

ggcctggctg gaaaaagagt ggtccctgcc ttctgatgtg gccgaagccg tggctaatgc     1560

ccatctgcct gatggccacg gaagatttgg cctgacagcc accgttagac tgctcgaaca     1620

cctgaaagcc gacgtggtca catatgccga agctgctcgg agagccggct tccaccactc     1680

tgatttcaga gatggcgcct gctacgacga gctgccttac tatggcgaga tcctgagcag     1740

agagatcgcc cctggaaagg acgagtacgg cgatccactg gaaagacagt ggggcaagat     1800

cacaaacccc accgtgcaca tcggcctgaa tcagctgaga aggctgatta acgccctcgt     1860

gcggagacac ggcagacccg atttcatctt cgtggaactg gcccgcgagc tgaagctgaa     1920

tgagaagcag aaggccgacc acaagcggcg gatcaagcag acaacagatg ccgctagagc     1980

tagagccgag aagctgagag aaatcggaca gagagacagc ggctccaacc ggatgctgct     2040

gcggatttgg gaagaactga accccagcaa tcccctggac agaagatgcc cttattgcgc     2100

cgagcctatc tccatcgaga tgctgatgag cggcagcgcc gacatcgatc acatcgtgcc     2160

ttacagcaga tgcctggacg atagcgccgc caacaaagtg gtggcccaca accactgcaa     2220

cagacagaag ggcaacagaa ccccttggga gcagtgggga cagaccacaa gatggcccct     2280

gattcaagaa caggtggccc ggatgcacag atccaaacaa tggcgcttcg gccccgacgc     2340

catggaacga gttgatcgag atggcggctt tatcgcccgg cagctgacag atacccagta     2400

cctgtctaga atcgccgcac agtacctgag cgccctgtac acacctgatg aaggcagacg     2460

ggtgtacgcc gtgacaggca gactgactgc tatgcttaga cggctgtggg gcctgaacga     2520

catcctgcct gatcacaact gggtgctgaa ccctcacagc aacgccccta agaacaggct     2580

ggatcataga caccacgcca tcgatgccgc cgttgtggga gctacaacac ccgccatgat     2640

tcagcaggtt gccagagctg ctgcaagagc cgaggaacag gacctggata gactgttcgc     2700

tgacctgcct cctccatggc caggctttag agaggaactg cagggcagaa ttatggccgc     2760

tgtggtgtct cacaagcccg accatggaag aaagggcaga ccactgcctg gcagagatag     2820

cacatccggc agactgcaca atgacaccgc ctacggcttt actggccgca gaaatgccaa     2880

gggcatgcct atcgtggtca ccagaaaacc cctgctggcc ctgaaacctg aggacctgac     2940

agaccccgag agaatcccag atcctgctct gcagggcgca ctgtttgaag ccactagagg     3000

cgctaccggc aaggacttcg agaaagccct gcgggacttc agcagaagag atggccctta     3060

ccagggcatc agacggatta gactgaccga ggctctgaac gtgatcccca tcagagatag     3120

aaccggccac gcctacaaag gcgtgaaagg cgacgccaac gccagattcg atgtttggag     3180

actgcccgac ggcaagtgga tcaccagatg gaaggataga gatggcatcg agcacagcgg     3240

catcgtgtcc ctgtttgatg ctcaccagcc tagccaggtg taccacagac ctcatcctgc     3300

cgccaaaaag gtgctgagcc tgagacagaa tgacctggtg gcagtggaac acgatggcga     3360

ccccggaaag atcatgcggg tcgtgaagtt tagcgccaac ggcagcatca cattcgcccc     3420

acataatgag gccggacctc tgaaaacccg ggacaccgat cctgccgatc ctttcagata     3480

cgtgacaaca gtggccagcg gcctgaagaa gatgagagcc agacaagtgc ggatcgatga     3540

gctgggcaaa gtgcacgatc ccggacctag agaggatgga tccccaaaaa agaaaagaaa     3600

agttgctgcc gcactcgagc atcatcacca tcaccatcat cattaagcgg ccgcctagca     3660

taaccccttg gggcctctaa acgggtcttg aggggttttt tgacctaggc taggggatat     3720

attccgcttc ctcgctcact gactcgctac gctcggtcgt tcgactgcgg cgagcggaaa     3780

tggcttacga acggggcgga gatttcctgg aagatgccag gaagatactt aacagggaag     3840

tgagagggcc gcggcaaagc cgtttttcca taggctccgc ccccctgaca agcatcacga     3900

aatctgacgc tcaaatcagt ggtggcgaaa cccgacagga ctataaagat accaggcgtt     3960

tccccctggc ggctccctcg tgcgctctcc tgttcctgcc tttcggttta ccggtgtcat     4020

tccgctgtta tggccgcgtt tgtctcattc cacgcctgac actcagttcc gggtaggcag     4080

ttcgctccaa gctggactgt atgcacgaac cccccgttca gtccgaccgc tgcgccttat     4140

ccggtaacta tcgtcttgag tccaacccgg aaagacatgc aaaagcacca ctggcagcag     4200

ccactggtaa ttgatttaga ggagttagtc ttgaagtcat gcgccggtta aggctaaact     4260

gaaaggacaa gttttggtga ctgcgctcct ccaagccagt tacctcggtt caaagagttg     4320

gtagctcaga gaaccttcga aaaaccgccc tgcaaggcgg ttttttcgtt ttcagagcaa     4380

gagattacgc gcagaccaaa acgatctcaa gaagatcatc ttattaatca gataaaatat     4440

ttctagattt cagtgcaatt tatctcttca aatgtagcac ctgaagtcag ccccatacga     4500

tataagttgt tactagtgct tggattctca ccaataaaaa acgcccggcg gcaaccgagc     4560

gttctgaaca aatccagatg gagttctgag gtcattactg gatctatcaa caggagtcca     4620

agcgagctcg taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     4680

agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac     4740

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcggg agccacgctc     4800

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg     4860

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag     4920

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc     4980

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac     5040

atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag     5100

aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac     5160

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg     5220

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc     5280

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact     5340

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg     5400

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa     5460

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt     5520

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg     5580

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga     5640

cgtcctcgag tcccggtgcc taatgagtga gctaacttac attaattgcg ttgcgctcac     5700

tgcccgcttt ccagtcggga aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg     5760

cggggagagg cggtttgcgt attgggcgcc agggtggttt ttcttttcac cagtgacacg     5820

ggcaacagct gattgccctt caccgcctgg ccctgagaga gttgcagcaa gcggtccacg     5880

ctggtttgcc ccagcaggcg aaaatcctgt ttgatggtgg ttaacggcgg gatataacat     5940

gagctgtctt cggtatcgtc gtatcccact accgagatgt ccgcaccaac gcgcagcccg     6000

gactcggtaa tggcgcgcat tgcgcccagc gccatctgat cgttggcaac cagcatcgca     6060

gtgggaacga tgccctcatt cagcatttgc atggtttgtt gaaaaccgga catggcactc     6120

cagtcgcctt cccgttccgc tatcggctga atttgattgc gagtgagata tttatgccag     6180

ccagccagac gcagacgcgc cgagacagaa cttaatgggc ccgctaacag cgcgatttgc     6240

tggtgaccca atgcgaccag atgctccacg cccagtcgcg taccgtcttc atgggagaaa     6300

ataatactgt tgatgggtgt ctggtcagag acatcaagaa ataacgccgg aacattagtg     6360

caggcagctt ccacagcaat ggcatcctgg tcatccagcg gatagttaat gatcagccca     6420

ctgacgcgtt gcgcgagaag attgtgcacc gccgctttac aggcttcgac gccgcttcgt     6480

tctaccatcg acaccaccac gctggcaccc agttgatcgg cgcgagattt aatcgccgcg     6540

acaatttgcg acggcgcgtg cagggccaga ctggaggtgg caacgccaat cagcaacgac     6600

tgtttgcccg ccagtt                                                     6616


<210>  122
<211>  2549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  122
gcataaccaa gcctatgcct acagcatcca gggtgacggt gccgaggatg acgatgagcg       60

cattgttaga tttcatacac ggtgcctgac tgcgttagca atttaactgt gataaactac      120

cgcattaaag cttatcgatg ataagctgtc aacacatttc cccgaaaagt gccacctgac      180

gtcctcgagt cccgcataat cgaaattaat acgactcact atagggaaga gcagagcctt      240

ggtctcgttg ccgctggaga aatccagttg ttaacaagca gcttgactgc accaaataag      300

gcgggggctg cggccctcgc ttttttgaat tcttccgctg agcaataact agcataaccc      360

cttggggcct ctaaacgggt cttgaggggt tttttgacct aggctagggg atatattccg      420

cttcctcgcg gtaccccgct tcctcgctca ctgactcgct acgctcggtc gttcgactgc      480

ggcgagcgga aatggcttac gaacggggcg gagatttcct ggaagatgcc aggaagatac      540

ttaacaggga agtgagaggg ccgcggcaaa gccgtttttc cataggctcc gcccccctga      600

caagcatcac gaaatctgac gctcaaatca gtggtggcga aacccgacag gactataaag      660

ataccaggcg tttccccctg gcggctccct cgtgcgctct cctgttcctg cctttcggtt      720

taccggtgtc attccgctgt tatggccgcg tttgtctcat tccacgcctg acactcagtt      780

ccgggtaggc agttcgctcc aagctggact gtatgcacga accccccgtt cagtccgacc      840

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggaaagacat gcaaaagcac      900

cactggcagc agccactggt aattgattta gaggagttag tcttgaagtc atgcgccggt      960

taaggctaaa ctgaaaggac aagttttggt gactgcgctc ctccaagcca gttacctcgg     1020

ttcaaagagt tggtagctca gagaaccttc gaaaaaccgc cctgcaaggc ggttttttcg     1080

ttttcagagc aagagattac gcgcagacca aaacgatctc aagaagatca tcttattaat     1140

cagataaaat atttctagat ttcagtgcaa tttatctctt caaatgtagc acctgaagtc     1200

agccccatac gatataagtt gttactagtg cttggattct caccaataaa aaacgcccgg     1260

cggcaaccga gcgttctgaa caaatccaga tggagttctg aggtcattac tggatctatc     1320

aacaggagtc caagcgagaa gggttggttt gcgcattcac agttctccgc aagaattgat     1380

tggctccaat tcttggagtg gtgaatccgt tagcgaggtg ccgccggctt ccattcaggt     1440

cgaggtggcc cggctccatg caccgcgacg caacgcgggg aggcagacaa ggtatagggc     1500

ggcgcctaca atccatgcca acccgttcca tgtgctcgcc gaggcggcat aaatcgccgt     1560

gacgatcagc ggtccaatga tcgaagttag gctggtaaga gccgcgagcg atccttgaag     1620

ctgtccctga tggtcgtcat ctacctgcct ggacagcatg gcctgcaacg cgggcatccc     1680

gatgccgccg gaagcgagaa gaatcataat ggggaaggcc atccagcctc gcgtcgcgaa     1740

cgccagcaag acgtagccca gcgcgtcggc cgccatgccg gcgataatgg cctgcttctc     1800

gccgaaacgt ttggtggcgg gaccagtgac gaaggcttga gcgagggcgt gcaagattcc     1860

gaataccgca agcgacaggc cgatcatcgt cgcgctccag cgaaagcggt cctcgccgaa     1920

aatgacccag agcgctgccg gcacctgtcc tacgagttgc atgataaaga agacagtcat     1980

aagtgcggcg acgatagtca tgccccgcgc ccaccggaag gagctgactg ggttgaaggc     2040

tctcaagggc atcggtcgac gctctccctt atgcgactcc tgcattagga agcagcccag     2100

tagtaggttg aggccgttga gcaccgccgc cgcaaggaat ggtgcatgca aggagatggc     2160

gcccaacagt cccccggcca cggggcctgc caccataccc acgccgaaac aagcgctcat     2220

gagcccgaag tggcgagccc gatcttcccc atcggtgatg tcggcgatat aggcgccagc     2280

aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt ccggcgtaga ggatccacag     2340

gacgggtgtg gtcgccatga tcgcgtagtc gatagtggct ccaagtagcg aagcgagcag     2400

gactgggcgg cggccaaagc ggtcggacag tgctccgaga acgggtgcgc atagaaattg     2460

catcaacgca tatagcgcta gcagcacgcc atagtgactg gcgatgctgt cggaatggac     2520

gatatcccgc aagaggcccg gcagtaccg                                       2549


<210>  123
<211>  5009
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pbPOS T2 library


<220>
<221>  misc_feature
<222>  (3040)..(3047)
<223>  n is a, c, g, or t

<400>  123
tcgagtcttt acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac       60

aatttcacac atgattacgg attcaacgtc gtgactggta aaacccgggc gttacccaac      120

ttaatcgcct tgcagcacat ccccctttcg ccagcaggcg taataaggaa aggattcatg      180

tactatttga aaaacacaaa cttttggatg ttcggtttat tctttttctt ttactttttt      240

atcatgggag cctacttccc gtttttcccg atttggctac atgatatcaa ccatatcagc      300

aaaagtgata cgggtattat ttttgccgct atttctctgt tctcgctatt attccaaccg      360

ctgtttggtc tgctttctga caaactcggt ctacgcaaat acctgctgtg gattattacc      420

ggcatgttag tgatgtttgc gccgttcttt atttttatct tcgggccact gctgcagtac      480

aacattttag tagggtcgat tgttggtggt atttatctag gctttagttt taacgccggt      540

gcgccagcag tagaggcatt tattgagaaa gtcagccggc gcagtaattt cgaatttggt      600

cgcgcgcgga tgtttggcag tgttggctgg gcgctggttg cctcgattgt cgggatcatg      660

ttcaccatta ataatcagtt tgttttctgg ctgggctctg gcagttgtct catcctcgcc      720

gttttactct ttttcgccaa aacggacgcg ccctcaagtg ccacggttgc caatgcggta      780

ggtgccaacc attcggcatt tagccttaag ctggcactgg aactgttcag acagccaaaa      840

ctgtggtttt tgtcactgta tgttattggc gtttcctcca cctacgatgt ttttgaccaa      900

cagtttgcta atttctttac ttcgttcttt gctaccggtg aacagggtac ccgcgtattt      960

ggctacgtaa cgacaatggg cgaattactt aacgcctcga ttatgttctt tgcgccactg     1020

atcattaatc gcatcggtgg gaagaatgcc ctgctgctgg ctggcactat tatgtctgta     1080

cgtattattg gctcatcgtt cgccacctca gcgctggaag tggttattct gaaaacgctg     1140

catatgtttg aagtaccgtt cctgctggtg ggctccttta aatatattac tagtcagttt     1200

gaagtgcgtt tttcagcgac gatttatctg gtcagtttca gcttctttaa gcaactggcg     1260

atgattttta tgtctgtact ggcgggcaat atgtatgaaa gcataggttt ccaaggcgct     1320

tatctggtgc tgggtctggt ggcgctgggc ttcaccttaa tttccgtgtt cacgcttagc     1380

ggcccgggcc cgctttccct gctgcgtcgt caggtgaatg aagtcgctta aaggcctcga     1440

tgcagctagc atgctaatct gattcgttac caattatgac aacttgacgg ctacatcatt     1500

cactttttct tcacaaccgg cacggaactc gctcgggctg gccccggtgc attttttaaa     1560

tacccgcgag aaatagagtt gatcgtcaaa accaacattg cgaccgacgg tggcgatagg     1620

catccgggtg gtgctcaaaa gcagcttcgc ctggctgata cgttggtcct cgcgccagct     1680

taagacgcta atccctaact gctggcggaa aagatgtgac agacgcgacg gcgacaagca     1740

aacatgctgt gcgacgctgg cgatatcaaa attgctgtct gccaggtgat cgctgatgta     1800

ctgacaagcc tcgcgtaccc gattatccat cggtggatgg agcgactcgt taatcgcttc     1860

catgcgccgc agtaacaatt gctcaagcag atttatcgcc agcagctccg aatagcgccc     1920

ttccccttgc ccggcgttaa tgatttgccc aaacaggtcg ctgaaatgcg gctggtgcgc     1980

ttcatccggg cgaaagaacc ccgtattggc aaatattgac ggccagttaa gccattcatg     2040

ccagtaggcg cgcggacgaa agtaaaccca ctggtgatac cattcgcgag cctccggatg     2100

acgaccgtag tgatgaatct ctcctggcgg gaacagcaaa atatcacccg gtcggcaaac     2160

aaattctcgt ccctgatttt tcaccacccc ctgaccgcga atggtgagat tgagaatata     2220

acctttcatt cccagcggtc ggtcgataaa aaaatcgaga taaccgttgg cctcaatcgg     2280

cgttaaaccc gccaccagat gggcattaaa cgagtatccc ggcagcaggg gatcattttg     2340

cgcttcagcc atacttttca tactcccgcc attcagagaa gaaaccaatt gtccatattg     2400

catcagacat tgccgtcact gcgtctttta ctggctcttc tcgctaacca aaccggtaac     2460

cccgcttatt aaaagcattc tgtaacaaag cgggaccaaa gccatgacaa aaacgcgtaa     2520

caaaagtgtc tataatcacg gcagaaaagt ccacattgat tatttgcacg gcgtcacact     2580

ttgctatgcc atagcatttt tatccataag attagcggat cctacctgac gctttttatc     2640

gcaactctct actgtttctc catacccgtt tttttggggt agcgattgaa aacgatgcag     2700

tttaaggttt acacctataa aagagagagc cgttatcgtc tgtttgtgga tgtacagagt     2760

gatattattg acacgcccgg gcgacggatg gtgatccccc tggccagtgc acgtctgctg     2820

tcagataaag tctcccgtga actttacccg gtggtgcata tcggggatga aagctggcgc     2880

atgatgacca ccgatatggc cagtgtgccg gtctccgtta tcggggaaga agtggctgat     2940

ctcagccacc gcgaaaatga catcaaaaac gccattaacc tgatgttttg gggaatataa     3000

tcttctagac atacaatgga agagcagagc cttggtctcn nnnnnnnaag cttgatatcg     3060

aattcctgca gcccggggga tcccatggta cgcgtgctag aggcatcaaa taaaacgaaa     3120

ggctcagtcg aaagactggg cctttcgttt tatctgttgt ttgtcggtga acgctctcct     3180

gagtaggaca aatccgccgc cctagaccta ggcgttcggc tgcggcgagc ggtatcagct     3240

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     3300

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     3360

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     3420

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     3480

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     3540

gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     3600

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     3660

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     3720

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     3780

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc     3840

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     3900

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     3960

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     4020

actagtgctt ggattctcac caataaaaaa cgcccggcgg caaccgagcg ttctgaacaa     4080

atccagatgg agttctgagg tcattactgg atctatcaac aggagtccaa gcgagctcga     4140

tatcaaatta cgccccgccc tgccactcat cgcagtactg ttgtaattca ttaagcattc     4200

tgccgacatg gaagccatca cagacggcat gatgaacctg aatcgccagc ggcatcagca     4260

ccttgtcgcc ttgcgtataa tatttgccca tggtgaaaac gggggcgaag aagttgtcca     4320

tattggccac gtttaaatca aaactggtga aactcaccca gggattggct gagacgaaaa     4380

acatattctc aataaaccct ttagggaaat aggccaggtt ttcaccgtaa cacgccacat     4440

cttgcgaata tatgtgtaga aactgccgga aatcgtcgtg gtattcactc cagagcgatg     4500

aaaacgtttc agtttgctca tggaaaacgg tgtaacaagg gtgaacacta tcccatatca     4560

ccagctcacc gtctttcatt gccatacgga attccggatg agcattcatc aggcgggcaa     4620

gaatgtgaat aaaggccgga taaaacttgt gcttattttt ctttacggtc tttaaaaagg     4680

ccgtaatatc cagctgaacg gtctggttat aggtacattg agcaactgac tgaaatgcct     4740

caaaatgttc tttacgatgc cattgggata tatcaacggt ggtatatcca gtgatttttt     4800

tctccatttt agcttcctta gctcctgaaa atctcgataa ctcaaaaaat acgcccggta     4860

gtgatcttat ttcattatgg tgaaagttgg aacctcttac gtgccgatca acgtctcatt     4920

ttcgccagat atcgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag     4980

gcgtatcacg aggccctttc gtcttcacc                                       5009


<210>  124
<211>  5515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pET9a

<400>  124
taatacgact cactataggg agaccacaac ggtttccctc tagagagaca ataaccctga       60

taatgcttca ataatattga aaaaggaaga gtatgcctaa gaagaagaga aaggtgggta      120

ccgagaagag actgggcctc gacatcggca caaatagcat cggctggtgc ctgtacgagg      180

gcgactctat cctggatatc ggcgtgcgga tcttcagcga cggcagagat cctaaatctg      240

gcgcctctct ggccgtggac agacggaatg ctagagccat gcggcggaga agggatagat      300

acctgggaag aagaagcgcc ctgatcaagg ccctgaaggc ccatggactg tttccagccg      360

aacaggatgc cgccaaggct ctggaaagag aggaccctta cagcctgaga gtcagagccc      420

tggatcacag actggaccct catcagatcg gcagagccat cttccacctg aaccagcgga      480

gaggcttcag aagcaacaga aaggccgaca gagtgctggg cgatcaagag agcggactga      540

tcagcacagc caccagagtt ctggacgaag ccatggccaa aagcggcgct agaacactgg      600

gagagtttct ggccagccgg gacactagaa gagtgcggat gaggcctgac gtgaagggct      660

acgacttcta ccccaaccgg cagcactacc tggaagagtt cgagaagatc tgggacgccc      720

agagccagta tcaccctgat ctgctgtctc agcaggccaa gagcgccatc caccggatca      780

tttttcacca gaggccactg aagccacagg ccgtgggaac atgtacattt gccggactgc      840

atggcatccc cggcgacgag acaagactgc ctaaagctca ccctctgttc cagcagcggc      900

ggctgtatga ggaagtgaac cagctggaaa tcgtgtgcgc cagcgctcct gccagaaagc      960

tgaccagaga tgagagagat gccctgatcc tgaagctgca ggacaagaaa aaagtgacct     1020

tcagcacact ggcccggacc atcagactga aagagggcga gagattcaac aaagagagcg     1080

agaaccggaa ggacctggct ggggatgaag tgcgggccga gatgagcgat aagaccagat     1140

tcggcagacg gtggtttcac ctgagcctgg atgagcagtg gtccgtgatc gacagactgc     1200

tgaacgagga aagcaccgag gatctgctgg cctggctgga aaaagagtgg tccctgcctt     1260

ctgatgtggc cgaagccgtg gctaatgccc atctgcctga tggccacgga agatttggcc     1320

tgacagccac cgttagactg ctcgaacacc tgaaagccga cgtggtcaca tatgccgaag     1380

ctgctcggag agccggcttc caccactctg atttcagaga tggcgcctgc tacgacgagc     1440

tgccttacta tggcgagatc ctgagcagag agatcgcccc tggaaaggac gagtacggcg     1500

atccactgga aagacagtgg ggcaagatca caaaccccac cgtgcacatc ggcctgaatc     1560

agctgagaag gctgattaac gccctcgtgc ggagacacgg cagacccgat ttcatcttcg     1620

tggaactggc ccgcgagctg aagctgaatg agaagcagaa ggccgaccac aagcggcgga     1680

tcaagcagac aacagatgcc gctagagcta gagccgagaa gctgagagaa atcggacaga     1740

gagacagcgg ctccaaccgg atgctgctgc ggatttggga agaactgaac cccagcaatc     1800

ccctggacag aagatgccct tattgcgccg agcctatctc catcgagatg ctgatgagcg     1860

gcagcgccga catcgatcac atcgtgcctt acagcagatg cctggacgat agcgccgcca     1920

acaaagtggt ggcccacaac cactgcaaca gacagaaggg caacagaacc ccttgggagc     1980

agtggggaca gaccacaaga tggcccctga ttcaagaaca ggtggcccgg atgcacagat     2040

ccaaacaatg gcgcttcggc cccgacgcca tggaacgagt tgatcgagat ggcggcttta     2100

tcgcccggca gctgacagat acccagtacc tgtctagaat cgccgcacag tacctgagcg     2160

ccctgtacac acctgatgaa ggcagacggg tgtacgccgt gacaggcaga ctgactgcta     2220

tgcttagacg gctgtggggc ctgaacgaca tcctgcctga tcacaactgg gtgctgaacc     2280

ctcacagcaa cgcccctaag aacaggctgg atcatagaca ccacgccatc gatgccgccg     2340

ttgtgggagc tacaacaccc gccatgattc agcaggttgc cagagctgct gcaagagccg     2400

aggaacagga cctggataga ctgttcgctg acctgcctcc tccatggcca ggctttagag     2460

aggaactgca gggcagaatt atggccgctg tggtgtctca caagcccgac catggaagaa     2520

agggcagacc actgcctggc agagatagca catccggcag actgcacaat gacaccgcct     2580

acggctttac tggccgcaga aatgccaagg gcatgcctat cgtggtcacc agaaaacccc     2640

tgctggccct gaaacctgag gacctgacag accccgagag aatcccagat cctgctctgc     2700

agggcgcact gtttgaagcc actagaggcg ctaccggcaa ggacttcgag aaagccctgc     2760

gggacttcag cagaagagat ggcccttacc agggcatcag acggattaga ctgaccgagg     2820

ctctgaacgt gatccccatc agagatagaa ccggccacgc ctacaaaggc gtgaaaggcg     2880

acgccaacgc cagattcgat gtttggagac tgcccgacgg caagtggatc accagatgga     2940

aggatagaga tggcatcgag cacagcggca tcgtgtccct gtttgatgct caccagccta     3000

gccaggtgta ccacagacct catcctgccg ccaaaaaggt gctgagcctg agacagaatg     3060

acctggtggc agtggaacac gatggcgacc ccggaaagat catgcgggtc gtgaagttta     3120

gcgccaacgg cagcatcaca ttcgccccac ataatgaggc cggacctctg aaaacccggg     3180

acaccgatcc tgccgatcct ttcagatacg tgacaacagt ggccagcggc ctgaagaaga     3240

tgagagccag acaagtgcgg atcgatgagc tgggcaaagt gcacgatccc ggacctagag     3300

aggatggatc ctacccatac gatgttccag attacgcggc cgctccaaaa aagaaaagaa     3360

aagttgcggc tagccatcat caccatcacc atcatcatta aggctgctaa caaagcccga     3420

aaggaagctg agttggctgc tgccaccgct gagcaataac tagcataacc ccttggggcc     3480

tctaaacggg tcttgagggg ttttttgctg aaaggaggaa ctatatccgg atatccacag     3540

gacgggtgtg gtcgccatga tcgcgtagtc gatagtggct ccaagtagcg aagcgagcag     3600

gactgggcgg cggccaaagc ggtcggacag tgctccgaga acgggtgcgc atagaaattg     3660

catcaacgca tatagcgcta gcagcacgcc atagtgactg gcgatgctgt cggaatggac     3720

gatatcccgc aagaggcccg gcagtaccgg cataaccaag cctatgccta cagcatccag     3780

ggtgacggtg ccgaggatga cgatgagcgc attgttagat ttcatacacg gtgcctgact     3840

gcgttagcaa tttaactgtg ataaactacc gcattaaagc ttatcgatga taagctgtca     3900

aacatgagaa ttcttagaaa aactcatcga gcatcaaatg aaactgcaat ttattcatat     3960

caggattatc aataccatat ttttgaaaaa gccgtttctg taatgaagga gaaaactcac     4020

cgaggcagtt ccataggatg gcaagatcct ggtatcggtc tgcgattccg actcgtccaa     4080

catcaataca acctattaat ttcccctcgt caaaaataag gttatcaagt gagaaatcac     4140

catgagtgac gactgaatcc ggtgagaatg gcaaaagctt atgcatttct ttccagactt     4200

gttcaacagg ccagccatta cgctcgtcat caaaatcact cgcatcaacc aaaccgttat     4260

tcattcgtga ttgcgcctga gcgagacgaa atacgcgatc gctgttaaaa ggacaattac     4320

aaacaggaat cgaatgcaac cggcgcagga acactgccag cgcatcaaca atattttcac     4380

ctgaatcagg atattcttct aatacctgga atgctgtttt cccggggatc gcagtggtga     4440

gtaaccatgc atcatcagga gtacggataa aatgcttgat ggtcggaaga ggcataaatt     4500

ccgtcagcca gtttagtctg accatctcat ctgtaacatc attggcaacg ctacctttgc     4560

catgtttcag aaacaactct ggcgcatcgg gcttcccata caatcgatag attgtcgcac     4620

ctgattgccc gacattatcg cgagcccatt tatacccata taaatcagca tccatgttgg     4680

aatttaatcg cggcctcgag caagacgttt cccgttgaat atggctcata acaccccttg     4740

tattactgtt tatgtaagca gacagtttta ttgttcatga ccaaaatccc ttaacgtgag     4800

ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct     4860

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt     4920

tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg     4980

cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt caagaactct     5040

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc     5100

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg     5160

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa     5220

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg     5280

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg     5340

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga     5400

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt     5460

ttacggttcc tggccttttg ctggcctttt gctcacatgt tcgatcccgc gaaat          5515


<210>  125
<211>  9428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pmOMNI

<400>  125
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttgcca ccatgcctaa gaagaagaga aaggtgggta ccgagaagag      960

actgggcctc gacatcggca caaatagcat cggctggtgc ctgtacgagg gcgactctat     1020

cctggatatc ggcgtgcgga tcttcagcga cggcagagat cctaaatctg gcgcctctct     1080

ggccgtggac agacggaatg ctagagccat gcggcggaga agggatagat acctgggaag     1140

aagaagcgcc ctgatcaagg ccctgaaggc ccatggactg tttccagccg aacaggatgc     1200

cgccaaggct ctggaaagag aggaccctta cagcctgaga gtcagagccc tggatcacag     1260

actggaccct catcagatcg gcagagccat cttccacctg aaccagcgga gaggcttcag     1320

aagcaacaga aaggccgaca gagtgctggg cgatcaagag agcggactga tcagcacagc     1380

caccagagtt ctggacgaag ccatggccaa aagcggcgct agaacactgg gagagtttct     1440

ggccagccgg gacactagaa gagtgcggat gaggcctgac gtgaagggct acgacttcta     1500

ccccaaccgg cagcactacc tggaagagtt cgagaagatc tgggacgccc agagccagta     1560

tcaccctgat ctgctgtctc agcaggccaa gagcgccatc caccggatca tttttcacca     1620

gaggccactg aagccacagg ccgtgggaac atgtacattt gccggactgc atggcatccc     1680

cggcgacgag acaagactgc ctaaagctca ccctctgttc cagcagcggc ggctgtatga     1740

ggaagtgaac cagctggaaa tcgtgtgcgc cagcgctcct gccagaaagc tgaccagaga     1800

tgagagagat gccctgatcc tgaagctgca ggacaagaaa aaagtgacct tcagcacact     1860

ggcccggacc atcagactga aagagggcga gagattcaac aaagagagcg agaaccggaa     1920

ggacctggct ggggatgaag tgcgggccga gatgagcgat aagaccagat tcggcagacg     1980

gtggtttcac ctgagcctgg atgagcagtg gtccgtgatc gacagactgc tgaacgagga     2040

aagcaccgag gatctgctgg cctggctgga aaaagagtgg tccctgcctt ctgatgtggc     2100

cgaagccgtg gctaatgccc atctgcctga tggccacgga agatttggcc tgacagccac     2160

cgttagactg ctcgaacacc tgaaagccga cgtggtcaca tatgccgaag ctgctcggag     2220

agccggcttc caccactctg atttcagaga tggcgcctgc tacgacgagc tgccttacta     2280

tggcgagatc ctgagcagag agatcgcccc tggaaaggac gagtacggcg atccactgga     2340

aagacagtgg ggcaagatca caaaccccac cgtgcacatc ggcctgaatc agctgagaag     2400

gctgattaac gccctcgtgc ggagacacgg cagacccgat ttcatcttcg tggaactggc     2460

ccgcgagctg aagctgaatg agaagcagaa ggccgaccac aagcggcgga tcaagcagac     2520

aacagatgcc gctagagcta gagccgagaa gctgagagaa atcggacaga gagacagcgg     2580

ctccaaccgg atgctgctgc ggatttggga agaactgaac cccagcaatc ccctggacag     2640

aagatgccct tattgcgccg agcctatctc catcgagatg ctgatgagcg gcagcgccga     2700

catcgatcac atcgtgcctt acagcagatg cctggacgat agcgccgcca acaaagtggt     2760

ggcccacaac cactgcaaca gacagaaggg caacagaacc ccttgggagc agtggggaca     2820

gaccacaaga tggcccctga ttcaagaaca ggtggcccgg atgcacagat ccaaacaatg     2880

gcgcttcggc cccgacgcca tggaacgagt tgatcgagat ggcggcttta tcgcccggca     2940

gctgacagat acccagtacc tgtctagaat cgccgcacag tacctgagcg ccctgtacac     3000

acctgatgaa ggcagacggg tgtacgccgt gacaggcaga ctgactgcta tgcttagacg     3060

gctgtggggc ctgaacgaca tcctgcctga tcacaactgg gtgctgaacc ctcacagcaa     3120

cgcccctaag aacaggctgg atcatagaca ccacgccatc gatgccgccg ttgtgggagc     3180

tacaacaccc gccatgattc agcaggttgc cagagctgct gcaagagccg aggaacagga     3240

cctggataga ctgttcgctg acctgcctcc tccatggcca ggctttagag aggaactgca     3300

gggcagaatt atggccgctg tggtgtctca caagcccgac catggaagaa agggcagacc     3360

actgcctggc agagatagca catccggcag actgcacaat gacaccgcct acggctttac     3420

tggccgcaga aatgccaagg gcatgcctat cgtggtcacc agaaaacccc tgctggccct     3480

gaaacctgag gacctgacag accccgagag aatcccagat cctgctctgc agggcgcact     3540

gtttgaagcc actagaggcg ctaccggcaa ggacttcgag aaagccctgc gggacttcag     3600

cagaagagat ggcccttacc agggcatcag acggattaga ctgaccgagg ctctgaacgt     3660

gatccccatc agagatagaa ccggccacgc ctacaaaggc gtgaaaggcg acgccaacgc     3720

cagattcgat gtttggagac tgcccgacgg caagtggatc accagatgga aggatagaga     3780

tggcatcgag cacagcggca tcgtgtccct gtttgatgct caccagccta gccaggtgta     3840

ccacagacct catcctgccg ccaaaaaggt gctgagcctg agacagaatg acctggtggc     3900

agtggaacac gatggcgacc ccggaaagat catgcgggtc gtgaagttta gcgccaacgg     3960

cagcatcaca ttcgccccac ataatgaggc cggacctctg aaaacccggg acaccgatcc     4020

tgccgatcct ttcagatacg tgacaacagt ggccagcggc ctgaagaaga tgagagccag     4080

acaagtgcgg atcgatgagc tgggcaaagt gcacgatccc ggacctagag aggatggatc     4140

ctacccatac gatgttccag attacgcggc cgctccaaaa aagaaaagaa aagttgaatt     4200

cggcggcagc ggcgccacca acttcagcct gctgaagcag gccggcgacg tggaggagaa     4260

ccccggcccc atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat     4320

gcgcttcaag gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga     4380

gggcgagggc cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg     4440

ccccctgccc ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta     4500

cgtgaagcac cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa     4560

gtgggagcgc gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc     4620

cctgcaggac ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga     4680

cggccccgta atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc     4740

cgaggacggc gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca     4800

ctacgacgct gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc     4860

ctacaacgtc aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga     4920

acagtacgaa cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaagta     4980

gctcgagtct agagggcccg tttaaacccg ctgatcagcc tcgactgtgc cttctagttg     5040

ccagccatct gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc     5100

cactgtcctt tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc     5160

tattctgggg ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag     5220

gcatgctggg gatgcggtgg gctctatggc ttctgaggcg gaaagaacca gctggggctc     5280

tagggggtat ccccacgcgc cctgtagcgg cgcattaagc gcggcgggtg tggtggttac     5340

gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg ctttcttccc     5400

ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg ggctcccttt     5460

agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt agggtgatgg     5520

ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt tggagtccac     5580

gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta tctcggtcta     5640

ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa atgagctgat     5700

ttaacaaaaa tttaacgcga attaattctg tggaatgtgt gtcagttagg gtgtggaaag     5760

tccccaggct ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc     5820

aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat     5880

tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt     5940

tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc     6000

gcctctgcct ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt     6060

tgcaaaaagc tcccgggagc ttgtatatcc attttcggat ctgatcaaga gacaggatga     6120

ggatcgtttc gcatgattga acaagatgga ttgcacgcag gttctccggc cgcttgggtg     6180

gagaggctat tcggctatga ctgggcacaa cagacaatcg gctgctctga tgccgccgtg     6240

ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca agaccgacct gtccggtgcc     6300

ctgaatgaac tgcaggacga ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct     6360

tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg actggctgct attgggcgaa     6420

gtgccggggc aggatctcct gtcatctcac cttgctcctg ccgagaaagt atccatcatg     6480

gctgatgcaa tgcggcggct gcatacgctt gatccggcta cctgcccatt cgaccaccaa     6540

gcgaaacatc gcatcgagcg agcacgtact cggatggaag ccggtcttgt cgatcaggat     6600

gatctggacg aagagcatca ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg     6660

cgcatgcccg acggcgagga tctcgtcgtg acccatggcg atgcctgctt gccgaatatc     6720

atggtggaaa atggccgctt ttctggattc atcgactgtg gccggctggg tgtggcggac     6780

cgctatcagg acatagcgtt ggctacccgt gatattgctg aagagcttgg cggcgaatgg     6840

gctgaccgct tcctcgtgct ttacggtatc gccgctcccg attcgcagcg catcgccttc     6900

tatcgccttc ttgacgagtt cttctgagcg ggactctggg gttcgaaatg accgaccaag     6960

cgacgcccaa cctgccatca cgagatttcg attccaccgc cgccttctat gaaaggttgg     7020

gcttcggaat cgttttccgg gacgccggct ggatgatcct ccagcgcggg gatctcatgc     7080

tggagttctt cgcccacccc aacttgttta ttgcagctta taatggttac aaataaagca     7140

atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt     7200

ccaaactcat caatgtatct tatcatgtct gtataccgtc gacctctagc tagagcttgg     7260

cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca     7320

acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca     7380

cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc     7440

attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt     7500

cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact     7560

caaaggcggt aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag     7620

caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata     7680

ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc     7740

cgacaggact ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg     7800

ttccgaccct gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc     7860

tttctcatag ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg     7920

gctgtgtgca cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc     7980

ttgagtccaa cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga     8040

ttagcagagc gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg     8100

gctacactag aagaacagta tttggtatct gcgctctgct gaagccagtt accttcggaa     8160

aaagagttgg tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg     8220

tttgcaagca gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt     8280

ctacggggtc tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat     8340

tatcaaaaag gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct     8400

aaagtatata tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta     8460

tctcagcgat ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa     8520

ctacgatacg ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac     8580

gctcaccggc tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa     8640

gtggtcctgc aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag     8700

taagtagttc gccagttaat agtttgcgca acgttgttgc cattgctaca ggcatcgtgg     8760

tgtcacgctc gtcgtttggt atggcttcat tcagctccgg ttcccaacga tcaaggcgag     8820

ttacatgatc ccccatgttg tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg     8880

tcagaagtaa gttggccgca gtgttatcac tcatggttat ggcagcactg cataattctc     8940

ttactgtcat gccatccgta agatgctttt ctgtgactgg tgagtactca accaagtcat     9000

tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc ggcgtcaata cgggataata     9060

ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa     9120

aactctcaag gatcttaccg ctgttgagat ccagttcgat gtaacccact cgtgcaccca     9180

actgatcttc agcatctttt actttcacca gcgtttctgg gtgagcaaaa acaggaaggc     9240

aaaatgccgc aaaaaaggga ataagggcga cacggaaatg ttgaatactc atactcttcc     9300

tttttcaata ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg     9360

aatgtattta gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac     9420

ctgacgtc                                                              9428


<210>  126
<211>  2726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pmGuide T2/Endogenic site

<400>  126
ggaagagcag agccttggtc tcgttccggc tagaggaaac tctggacgct aacaagctga       60

aagatgcacc aaatgatagg gtcgctatag gcgacccttt ttgaattctt ccgctgagca      120

ataactagca taaccccttg gggcctctaa acgggtcttg aggggttttt tgacctaggc      180

taggggatat attccgcttc ctcgcggtac cccgcttcct cgctcactga ctcgctacgc      240

tcggtcgttc gactgcggcg agcggaaatg gcttacgaac ggggcggaga tttcctggaa      300

gatgccagga agatacttaa cagggaagtg agagggccgc ggcaaagccg tttttccata      360

ggctccgccc ccctgacaag catcacgaaa tctgacgctc aaatcagtgg tggcgaaacc      420

cgacaggact ataaagatac caggcgtttc cccctggcgg ctccctcgtg cgctctcctg      480

ttcctgcctt tcggtttacc ggtgtcattc cgctgttatg gccgcgtttg tctcattcca      540

cgcctgacac tcagttccgg gtaggcagtt cgctccaagc tggactgtat gcacgaaccc      600

cccgttcagt ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggaa      660

agacatgcaa aagcaccact ggcagcagcc actggtaatt gatttagagg agttagtctt      720

gaagtcatgc gccggttaag gctaaactga aaggacaagt tttggtgact gcgctcctcc      780

aagccagtta cctcggttca aagagttggt agctcagaga accttcgaaa aaccgccctg      840

caaggcggtt ttttcgtttt cagagcaaga gattacgcgc agaccaaaac gatctcaaga      900

agatcatctt attaatcaga taaaatattt ctagatttca gtgcaattta tctcttcaaa      960

tgtagcacct gaagtcagcc ccatacgata taagttgtta ctagtgcttg gattctcacc     1020

aataaaaaac gcccggcggc aaccgagcgt tctgaacaaa tccagatgga gttctgaggt     1080

cattactgga tctatcaaca ggagtccaag cgagaagggt tggtttgcgc attcacagtt     1140

ctccgcaaga attgattggc tccaattctt ggagtggtga atccgttagc gaggtgccgc     1200

cggcttccat tcaggtcgag gtggcccggc tccatgcacc gcgacgcaac gcggggaggc     1260

agacaaggta tagggcggcg cctacaatcc atgccaaccc gttccatgtg ctcgccgagg     1320

cggcataaat cgccgtgacg atcagcggtc caatgatcga agttaggctg gtaagagccg     1380

cgagcgatcc ttgaagctgt ccctgatggt cgtcatctac ctgcctggac agcatggcct     1440

gcaacgcggg catcccgatg ccgccggaag cgagaagaat cataatgggg aaggccatcc     1500

agcctcgcgt cgcgaacgcc agcaagacgt agcccagcgc gtcggccgcc atgccggcga     1560

taatggcctg cttctcgccg aaacgtttgg tggcgggacc agtgacgaag gcttgagcga     1620

gggcgtgcaa gattccgaat accgcaagcg acaggccgat catcgtcgcg ctccagcgaa     1680

agcggtcctc gccgaaaatg acccagagcg ctgccggcac ctgtcctacg agttgcatga     1740

taaagaagac agtcataagt gcggcgacga tagtcatgcc ccgcgcccac cggaaggagc     1800

tgactgggtt gaaggctctc aagggcatcg gtcgacgctc tcccttatgc gactcctgca     1860

ttaggaagca gcccagtagt aggttgaggc cgttgagcac cgccgccgca aggaatggtg     1920

catgcaagga gatggcgccc aacagtcccc cggccacggg gcctgccacc atacccacgc     1980

cgaaacaagc gctcatgagc ccgaagtggc gagcccgatc ttccccatcg gtgatgtcgg     2040

cgatataggc gccagcaacc gcacctgtgg cgccggtgat gccggccacg atgcgtccgg     2100

cgtagaggat ccacaggacg ggtgtggtcg ccatgatcgc gtagtcgata gtggctccaa     2160

gtagcgaagc gagcaggact gggcggcggc caaagcggtc ggacagtgct ccgagaacgg     2220

gtgcgcatag aaattgcatc aacgcatata gcgctagcag cacgccatag tgactggcga     2280

tgctgtcgga atggacgata tcccgcaaga ggcccggcag taccggcata accaagccta     2340

tgcctacagc atccagggtg acggtgccga ggatgacgat gagcgcattg ttagatttca     2400

tacacggtgc ctgactgcgt tagcaattta actgtgataa actaccgcat taaagcttat     2460

cgatgataag ctgtcaagag ggcctatttc ccatgattcc ttcatatttg catatacgat     2520

acaaggctgt tagagagata attagaatta atttgactgt aaacacaaag atattagtac     2580

aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta aaattatgtt     2640

ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc ttggctttat     2700

atatcttgtg gaaaggacga aacacc                                          2726


<210>  127
<211>  4194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPML3.1


<220>
<221>  misc_feature
<222>  (2256)..(2261)
<223>  n is a, c, g, or t

<400>  127
gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca       60

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      120

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc      180

agtggcgccc gaacagggac ttgaaagcga aagggaaacc agaggagctc tctcgacgca      240

ggactcggct tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc      300

caaaaatttt gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta      360

agcgggggag aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa      420

aatataaatt aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc      480

ctggcctgtt agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc      540

ttcagacagg atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg      600

tgcatcaaag gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc      660

aaaacaaaag taagaccacc gcacagcaag cggccgctga tcttcagacc tggaggagga      720

gatatgaggg acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca      780

ttaggagtag cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg      840

ggaataggag ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg      900

tcaatgacgc tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac      960

aatttgctga gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc     1020

aagcagctcc aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg     1080

gggatttggg gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt     1140

tggagtaata aatctctgga acagatttgg aatcacacga cctggatgga gtgggacaga     1200

gaaattaaca attacacaag cttaatacac tccttaattg aagaatcgca aaaccagcaa     1260

gaaaagaatg aacaagaatt attggaatta gataaatggg caagtttgtg gaattggttt     1320

aacataacaa attggctgtg gtatataaaa ttattcataa tgatagtagg aggcttggta     1380

ggtttaagaa tagtttttgc tgtactttct atagtgaata gagttaggca gggatattca     1440

ccattatcgt ttcagaccca cctcccaacc ccgaggggac ccgacaggcc cgaaggaata     1500

gaagaagaag gtggagagag agacagagac agatccattc gattagtgaa cggatctcga     1560

cggtatcgat aagcttggga gttccgcgtt acataactta cggtaaatgg cccgcctggc     1620

tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg     1680

ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg     1740

gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa     1800

tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac     1860

atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg     1920

cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg     1980

agtttgtttt ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca     2040

ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta     2100

gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac     2160

cgactctaga ggatccacta gtccagtgtg gtggaattct gcagatatca aagcttgcca     2220

ccatgcatac aatggaagag cagagccttg gtctcnnnnn ngcgggtctg gtggcgctag     2280

cgtgtccaag ggcgaggagc tgttcaccgg cgtggtgccc atcctggtgg agctggacgg     2340

cgacgtgaac ggccacaagt tcagcgtgag cggcgagggc gaaggggacg ctacttacgg     2400

caaactgact ctcaagttta tctgtactac cgggaagctc cctgtccctt ggcctacact     2460

ggtcacaact ctcacatatg gggtccagtg cttcagcaga taccccgacc acatgaagca     2520

gcacgacttc ttcaagagcg ccatgcccga gggctacgtg caggagagaa ccatcttctt     2580

caaggacgac ggcaactaca agaccagagc tgaggtcaag tttgagggtg acaccctggt     2640

gaacagaatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tgggccacaa     2700

gctggagtac aactacaaca gccacaacgt gtacatcatg gctgataaac agaagaatgg     2760

gattaaggtg aacttcaaga tcagacacaa catcgaggac ggcagcgtgc agctggccga     2820

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     2880

cctgagcacc cagagcgctc tcagtaagga ccctaatgag aagagagacc acatggtgct     2940

gctggagttc gtgaccgccg ccggcatcac cctgggcatg gacgagctgt acaagtgagg     3000

gcctaatgag tttggaatta attctgtgga atgtgtgtca gttagggtgt ggaaagtccc     3060

caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccaggt     3120

gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt     3180

cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg cccagttccg     3240

cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc gaggccgcct     3300

ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta ggcttttgca     3360

aaaagctccc gggagcttgt atatccattt tcggatctga tcagcacgtg ttgacaatta     3420

atcatcggca tagtatatcg gcatagtata atacgacaag gtgaggaact aaaccatggc     3480

caagcctttg tctcaagaag aatccaccct cattgaaaga gcaacggcta caatcaacag     3540

catccccatc tctgaagact acagcgtcgc cagcgcagct ctctctagcg acggccgcat     3600

cttcactggt gtcaatgtat atcattttac tgggggacct tgtgcagaac tcgtggtgct     3660

gggcactgct gctgctgcgg cagctggcaa cctgacttgt atcgtcgcga tcggaaatga     3720

gaacaggggc atcttgagcc cctgcggacg gtgccgacag gtgcttctcg atctgcatcc     3780

tgggatcaaa gccatagtga aggacagtga tggacagccg acggcagttg ggattcgtga     3840

attgctgccc tctggttatg tgtgggaggg ctaagcacaa ttcgagctcg gtacctttaa     3900

gaccaatgac ttacaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac     3960

tggaagggct aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc     4020

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta     4080

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact     4140

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct agca           4194


<210>  128
<211>  4566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV

<400>  128
tctagacaac tttgtataga aaagttggag ggcctatttc ccatgattcc ttcatatttg       60

catatacgat acaaggctgt tagagagata attggaatta atttgactgt aaacacaaag      120

atattagtac aaaatacgtg acgtagaaag taataatttc ttgggtagtt tgcagtttta      180

aaattatgtt ttaaaatgga ctatcatatg cttaccgtaa cttgaaagta tttcgatttc      240

ttggctttat atatcttgtg gaaaggacga aacaccggtg gaccaggtga ccaccgtgag      300

ttgccgctgg agaaatccag ttgttaacaa gcagcttgac tgcaccaaat aaggcggggg      360

ctgcggccct cgctttttca agtttgtaca aaaaagcagg cttagttatt aatagtaatc      420

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt      480

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta      540

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg      600

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      660

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt      720

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg      780

gcagtacatc aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc      840

cattgacgtc aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg      900

taacaactcc gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat      960

aagcagagct ggtttagtga accgtcagat cacccagctt tcttgtacaa agtgggccac     1020

catggcccct aagaagaaga gaaaggtggg taccgagaag agactgggcc tcgacatcgg     1080

cacaaatagc atcggctggt gcctgtacga gggcgactct atcctggata tcggcgtgcg     1140

gatcttcagc gacggcagag atcctaaatc tggcgcctct ctggccgtgg acagacggaa     1200

tgctagagcc atgcggcgga gaagggatag atacctggga agaagaagcg ccctgatcaa     1260

ggccctgaag gcccatggac tgtttccagc cgaacaggat gccgccaagg ctctggaaag     1320

agaggaccct tacagcctga gagtcagagc cctggatcac agactggacc ctcatcagat     1380

cggcagagcc atcttccacc tgaaccagcg gagaggcttc agaagcaaca gaaaggccga     1440

cagagtgctg ggcgatcaag agagcggact gatcagcaca gccaccagag ttctggacga     1500

agccatggcc aaaagcggcg ctagaacact gggagagttt ctggccagcc gggacactag     1560

aagagtgcgg atgaggcctg acgtgaaggg ctacgacttc taccccaacc ggcagcacta     1620

cctggaagag ttcgagaaga tctgggacgc ccagagccag tatcaccctg atctgctgtc     1680

tcagcaggcc aagagcgcca tccaccggat catttttcac cagaggccac tgaagccaca     1740

ggccgtggga acatgtacat ttgccggact gcatggcatc cccggcgacg agacaagact     1800

gcctaaagct caccctctgt tccagcagcg gcggctgtat gaggaagtga accagctgga     1860

aatcgtgtgc gccagcgctc ctgccagaaa gctgaccaga gatgagagag atgccctgat     1920

cctgaagctg caggacaaga aaaaagtgac cttcagcaca ctggcccgga ccatcagact     1980

gaaagagggc gagagattca acaaagagag cgagaaccgg aaggacctgg ctggggatga     2040

agtgcgggcc gagatgagcg ataagaccag attcggcaga cggtggtttc acctgagcct     2100

ggatgagcag tggtccgtga tcgacagact gctgaacgag gaaagcaccg aggatctgct     2160

ggcctggctg gaaaaagagt ggtccctgcc ttctgatgtg gccgaagccg tggctaatgc     2220

ccatctgcct gatggccacg gaagatttgg cctgacagcc accgttagac tgctcgaaca     2280

cctgaaagcc gacgtggtca catatgccga agctgctcgg agagccggct tccaccactc     2340

tgatttcaga gatggcgcct gctacgacga gctgccttac tatggcgaga tcctgagcag     2400

agagatcgcc cctggaaagg acgagtacgg cgatccactg gaaagacagt ggggcaagat     2460

cacaaacccc accgtgcaca tcggcctgaa tcagctgaga aggctgatta acgccctcgt     2520

gcggagacac ggcagacccg atttcatctt cgtggaactg gcccgcgagc tgaagctgaa     2580

tgagaagcag aaggccgacc acaagcggcg gatcaagcag acaacagatg ccgctagagc     2640

tagagccgag aagctgagag aaatcggaca gagagacagc ggctccaacc ggatgctgct     2700

gcggatttgg gaagaactga accccagcaa tcccctggac agaagatgcc cttattgcgc     2760

cgagcctatc tccatcgaga tgctgatgag cggcagcgcc gacatcgatc acatcgtgcc     2820

ttacagcaga tgcctggacg atagcgccgc caacaaagtg gtggcccaca accactgcaa     2880

cagacagaag ggcaacagaa ccccttggga gcagtgggga cagaccacaa gatggcccct     2940

gattcaagaa caggtggccc ggatgcacag atccaaacaa tggcgcttcg gccccgacgc     3000

catggaacga gttgatcgag atggcggctt tatcgcccgg cagctgacag atacccagta     3060

cctgtctaga atcgccgcac agtacctgag cgccctgtac acacctgatg aaggcagacg     3120

ggtgtacgcc gtgacaggca gactgactgc tatgcttaga cggctgtggg gcctgaacga     3180

catcctgcct gatcacaact gggtgctgaa ccctcacagc aacgccccta agaacaggct     3240

ggatcataga caccacgcca tcgatgccgc cgttgtggga gctacaacac ccgccatgat     3300

tcagcaggtt gccagagctg ctgcaagagc cgaggaacag gacctggata gactgttcgc     3360

tgacctgcct cctccatggc caggctttag agaggaactg cagggcagaa ttatggccgc     3420

tgtggtgtct cacaagcccg accatggaag aaagggcaga ccactgcctg gcagagatag     3480

cacatccggc agactgcaca atgacaccgc ctacggcttt actggccgca gaaatgccaa     3540

gggcatgcct atcgtggtca ccagaaaacc cctgctggcc ctgaaacctg aggacctgac     3600

agaccccgag agaatcccag atcctgctct gcagggcgca ctgtttgaag ccactagagg     3660

cgctaccggc aaggacttcg agaaagccct gcgggacttc agcagaagag atggccctta     3720

ccagggcatc agacggatta gactgaccga ggctctgaac gtgatcccca tcagagatag     3780

aaccggccac gcctacaaag gcgtgaaagg cgacgccaac gccagattcg atgtttggag     3840

actgcccgac ggcaagtgga tcaccagatg gaaggataga gatggcatcg agcacagcgg     3900

catcgtgtcc ctgtttgatg ctcaccagcc tagccaggtg taccacagac ctcatcctgc     3960

cgccaaaaag gtgctgagcc tgagacagaa tgacctggtg gcagtggaac acgatggcga     4020

ccccggaaag atcatgcggg tcgtgaagtt tagcgccaac ggcagcatca cattcgcccc     4080

acataatgag gccggacctc tgaaaacccg ggacaccgat cctgccgatc ctttcagata     4140

cgtgacaaca gtggccagcg gcctgaagaa gatgagagcc agacaagtgc ggatcgatga     4200

gctgggcaaa gtgcacgatc ccggacctag agaggatgga tcctacccat acgatgttcc     4260

agattacgcg gccgctccaa aaaagaaaag aaaagtttga caactttatt atacatagtt     4320

ggaattccta gagctcgctg atcagcctcg actgtgcctt ctagttgcca gccatctgtt     4380

gtttgcccct cccccgtgcc ttccttgacc ctggaaggtg ccactcccac tgtcctttcc     4440

taataaaatg aggaaattgc atcgcattgt ctgagtaggt gtcattctat tctggggggt     4500

ggggtggggc aggacagcaa gggggaggat tgggaagaga atagcaggca tgctggggag     4560

ggccgc                                                                4566


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-tag

<400>  129

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  130

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  131
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  131

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  132
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mCherry

<400>  132

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210>  133
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA-tag

<400>  133
tacccatacg atgttccaga ttacgct                                           27


<210>  134
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NLS

<400>  134
ccaaaaaaga aaagaaaagt t                                                 21


<210>  135
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  135
gccaccaact tcagcctgct gaagcaggcc ggcgacgtgg aggagaaccc cggcccc          57


<210>  136
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mCherry

<400>  136
atggtgagca agggcgagga ggataacatg gccatcatca aggagttcat gcgcttcaag       60

gtgcacatgg agggctccgt gaacggccac gagttcgaga tcgagggcga gggcgagggc      120

cgcccctacg agggcaccca gaccgccaag ctgaaggtga ccaagggtgg ccccctgccc      180

ttcgcctggg acatcctgtc ccctcagttc atgtacggct ccaaggccta cgtgaagcac      240

cccgccgaca tccccgacta cttgaagctg tccttccccg agggcttcaa gtgggagcgc      300

gtgatgaact tcgaggacgg cggcgtggtg accgtgaccc aggactcctc cctgcaggac      360

ggcgagttca tctacaaggt gaagctgcgc ggcaccaact tcccctccga cggccccgta      420

atgcagaaga agaccatggg ctgggaggcc tcctccgagc ggatgtaccc cgaggacggc      480

gccctgaagg gcgagatcaa gcagaggctg aagctgaagg acggcggcca ctacgacgct      540

gaggtcaaga ccacctacaa ggccaagaag cccgtgcagc tgcccggcgc ctacaacgtc      600

aacatcaagt tggacatcac ctcccacaac gaggactaca ccatcgtgga acagtacgaa      660

cgcgccgagg gccgccactc caccggcggc atggacgagc tgtacaagta g               711


<210>  137
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_CXCR4_S1

<400>  137
agcgcccgct tgggggagga gg                                                22


<210>  138
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_CXCR4_S2

<400>  138
caatataccc caagcaccga ag                                                22


<210>  139
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_PDCD1_S1

<400>  139
taagaaccat cctggccgcc ag                                                22


<210>  140
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_PDCD1_S2

<400>  140
gtaccagttt agcacgaagc tc                                                22


<210>  141
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_TRAC_S1

<400>  141
ctggaataat gctgttgttg aa                                                22


<210>  142
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_TRAC_S2

<400>  142
tgatgtcaag ctggtcgaga aa                                                22


<210>  143
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_CXCR4_S3

<400>  143
cgccaagtga taaacacgag ga                                                22


<210>  144
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_CXCR4_S4

<400>  144
ttgggcggga gtgtcagaaa at                                                22


<210>  145
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_PDCD1_S3

<400>  145
atcctggccg ccagcccagt tg                                                22


<210>  146
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_PDCD1_S4

<400>  146
taaactggta ccgcatgagc cc                                                22


<210>  147
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_TRAC_S3

<400>  147
agctgagaga ctctaaatcc ag                                                22


<210>  148
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_TRAC_S4

<400>  148
gacttcaaga gcaacagtgc tg                                                22


<210>  149
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_CXCR4_S25

<400>  149
tggcaagaga cccacacacc gg                                                22


<210>  150
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_CXCR4_S26

<400>  150
acacaccgga ggagcgcccg ct                                                22


<210>  151
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_g58_Ref

<400>  151
cagctgcggg aaagggattc cc                                                22


<210>  152
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_g35

<400>  152
gcagtccggg ctgggagcgg gt                                                22


<210>  153
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_CXCR4_S6

<400>  153
gggtatattg ggcgggagtg tc                                                22


<210>  154
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_CXCR4_S7

<400>  154
ccactacaag ttgcttgaag cc                                                22


<210>  155
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_PDCD1_S7

<400>  155
ggtcaccacg agcagggctg gg                                                22


<210>  156
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_PDCD1_S8

<400>  156
cacgaagctc tccgatgtgt tg                                                22


<210>  157
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_TRAC_S6

<400>  157
ttactttgtg acacatttgt tt                                                22


<210>  158
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_TRAC_S7

<400>  158
ggctggggaa gaaggtgtct tc                                                22


<210>  159
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_CXCR4_S1 3' (PAM containing) genomic seq

<400>  159
gccaagtgat aaacacgagg atggcaagag acccacacac cggaggagcg cccgcttggg       60

ggaggaggtg ccgtttgttc attttctgac actcccgccc aatatacccc aagcaccgaa      120

gggccttcgt tttaagaccg cattctcttt acccactaca agttgcttga agcccagaat      180

ggtttgtatt taggcaggcg tgggaaaatt aagtttttgc gctttaggag aatgagtctt      240

tgcaacgccc ccgccctccc cccgtgatcc tcccttctcc cctcttccct ccctgggcga      300

aaaacttctt acaaaaagtt aatcactgcc c                                     331


<210>  160
<211>  331
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_CXCR4_S2 3' (PAM containing) genomic seq

<400>  160
gccaagtgat aaacacgagg atggcaagag acccacacac cggaggagcg cccgcttggg       60

ggaggaggtg ccgtttgttc attttctgac actcccgccc aatatacccc aagcaccgaa      120

gggccttcgt tttaagaccg cattctcttt acccactaca agttgcttga agcccagaat      180

ggtttgtatt taggcaggcg tgggaaaatt aagtttttgc gctttaggag aatgagtctt      240

tgcaacgccc ccgccctccc cccgtgatcc tcccttctcc cctcttccct ccctgggcga      300

aaaacttctt acaaaaagtt aatcactgcc c                                     331


<210>  161
<211>  370
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_PDCD1_S1 3' (PAM containing) genomic seq

<400>  161
gctgctccag gcatgcagat cccacaggcg ccctggccag tcgtctgggc ggtgctacaa       60

ctgggctggc ggccaggatg gttcttaggt aggtggggtc ggcggtcagg tgtcccagag      120

ccaggggtct ggagggacct tccaccctca gtccctggca ggtcgggggg tgctgaggcg      180

ggcctggccc tggcagccca ggggtcccgg agcgaggggt ctggagggac ctttcactct      240

cagtccctgg caggtcgggg ggtgctgtgg caggcccagc cttggccccc agctctgccc      300

cttaccctga gctgtgtggc tttgggcagc tcgaactcct gggttcctct ctgggcccca      360

actcctcccc                                                             370


<210>  162
<211>  494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_PDCD1_S2 3' (PAM containing) genomic seq

<400>  162
ccctgctcgt ggtgaccgaa ggggacaacg ccaccttcac ctgcagcttc tccaacacat       60

cggagagctt cgtgctaaac tggtaccgca tgagccccag caaccagacg gacaagctgg      120

ccgccttccc cgaggaccgc agccagcccg gccaggactg ccgcttccgt gtcacacaac      180

tgcccaacgg gcgtgacttc cacatgagcg tggtcagggc ccggcgcaat gacagcggca      240

cctacctctg tggggccatc tccctggccc ccaaggcgca gatcaaagag agcctgcggg      300

cagagctcag ggtgacaggt gcggcctcgg aggccccggg gcaggggtga gctgagccgg      360

tcctggggtg ggtgtcccct cctgcacagg atcaggagct ccagggtcgt agggcaggga      420

ccccccagct ccagtccagg gctctgtcct gcacctgggg aatggtgacc ggcatctctg      480

tcctctagct ctgg                                                        494


<210>  163
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_TRAC_S1 3' (PAM containing) genomic seq

<400>  163
gtggcctgga gcaacaaatc tgactttgca tgtgcaaacg ccttcaacaa cagcattatt       60

ccagaagaca ccttcttccc cagcccaggt aagggcagct ttggtgcctt cgcaggctgt      120

ttccttgctt caggaatggc caggttctgc ccagagctct ggtcaatgat gtctaaaact      180

cctctgattg gtggtctcgg ccttatccat tgccaccaaa accctctttt tactaagaaa      240

cagtgagcct tgttctggca gtccagagaa tgacacggga aaaaagcaga tgaagagaag      300

gtggcaggag agggcacgtg gcccagcctc agtctctcca actgagttcc tgcctgcctg      360

cctttgctca gactgtttgc cccttactgc tcttctaggc ctcattctaa gccccttctc      420

caagttgcc                                                              429


<210>  164
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI59_TRAC_S2 3' (PAM containing) genomic seq

<400>  164
gcctgctctg gatgctgaaa gaatgtctgt ttttcctttt agaaagttcc tgtgatgtca       60

agctggtcga gaaaagcttt gaaacaggta agacaggggt ctagcctggg tttgcacagg      120

attgcggaag tgatgaaccc gcaataaccc tgcctggatg agggagtggg aagaaattag      180

tagatgtggg aatgaatgat gaggaatgga aacagcggtt caagacctgc ccagagctgg      240

gtggggtctc tcctgaatcc ctctcaccat ctctgacttt ccattctaag cactttgagg      300

atgagtttct agcttcaata gaccaaggac tctctcctag gcctctgtat tcctttcaac      360

agctccactg tcaagagagc cagagagagc ttctgggtgg cccagctgtg aaatttctga      420

gtcccttagg gatagcccta aacgaac                                          447


<210>  165
<211>  421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_CXCR4_S3 3' (PAM containing) genomic seq

<400>  165
ggaaatgaaa cttggggcga ggaccacggg tgcagacccc gttaccttct ccacccagga       60

aaatgccccg ctccctaacg tcccaaacgc gccaagtgat aaacacgagg atggcaagag      120

acccacacac cggaggagcg cccgcttggg ggaggaggtg ccgtttgttc attttctgac      180

actcccgccc aatatacccc aagcaccgaa gggccttcgt tttaagaccg cattctcttt      240

acccactaca agttgcttga agcccagaat ggtttgtatt taggcaggcg tgggaaaatt      300

aagtttttgc gctttaggag aatgagtctt tgcaacgccc ccgccctccc cccgtgatcc      360

tcccttctcc cctcttccct ccctgggcga aaaacttctt acaaaaagtt aatcactgcc      420

c                                                                      421


<210>  166
<211>  439
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_CXCR4_S4 3' (PAM containing) genomic seq

<400>  166
gatggcaaga gacccacaca ccggaggagc gcccgcttgg gggaggaggt gccgtttgtt       60

cattttctga cactcccgcc caatataccc caagcaccga agggccttcg ttttaagacc      120

gcattctctt tacccactac aagttgcttg aagcccagaa tggtttgtat ttaggcaggc      180

gtgggaaaat taagtttttg cgctttagga gaatgagtct ttgcaacgcc cccgccctcc      240

ccccgtgatc ctcccttctc ccctcttccc tccctgggcg aaaaacttct tacaaaaagt      300

taatcactgc ccctcctagc agcacccacc ccacccccca cgccgcctgg gagtggcctc      360

tttgtgtgta tttttttttt cctcctaagg aaggtttttt ttcttccctc tagtgggcgg      420

ggcagaggag ttagccaag                                                   439


<210>  167
<211>  386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_PDCD1_S3 3' (PAM containing) genomic seq

<400>  167
gctcacctcc gcctgagcag tggagaaggc ggcactctgg tggggctgct ccaggcatgc       60

agatcccaca ggcgccctgg ccagtcgtct gggcggtgct acaactgggc tggcggccag      120

gatggttctt aggtaggtgg ggtcggcggt caggtgtccc agagccaggg gtctggaggg      180

accttccacc ctcagtccct ggcaggtcgg ggggtgctga ggcgggcctg gccctggcag      240

cccaggggtc ccggagcgag gggtctggag ggacctttca ctctcagtcc ctggcaggtc      300

ggggggtgct gtggcaggcc cagccttggc ccccagctct gccccttacc ctgagctgtg      360

tggctttggg cagctcgaac tcctgg                                           386


<210>  168
<211>  494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_PDCD1_S4 3' (PAM containing) genomic seq

<400>  168
ccctgctcgt ggtgaccgaa ggggacaacg ccaccttcac ctgcagcttc tccaacacat       60

cggagagctt cgtgctaaac tggtaccgca tgagccccag caaccagacg gacaagctgg      120

ccgccttccc cgaggaccgc agccagcccg gccaggactg ccgcttccgt gtcacacaac      180

tgcccaacgg gcgtgacttc cacatgagcg tggtcagggc ccggcgcaat gacagcggca      240

cctacctctg tggggccatc tccctggccc ccaaggcgca gatcaaagag agcctgcggg      300

cagagctcag ggtgacaggt gcggcctcgg aggccccggg gcaggggtga gctgagccgg      360

tcctggggtg ggtgtcccct cctgcacagg atcaggagct ccagggtcgt agggcaggga      420

ccccccagct ccagtccagg gctctgtcct gcacctgggg aatggtgacc ggcatctctg      480

tcctctagct ctgg                                                        494


<210>  169
<211>  463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_TRAC_S3 3' (PAM containing) genomic seq

<400>  169
cctgggttgg ggcaaagagg gaaatgagat catgtcctaa ccctgatcct cttgtcccac       60

agatatccag aaccctgacc ctgccgtgta ccagctgaga gactctaaat ccagtgacaa      120

gtctgtctgc ctattcaccg attttgattc tcaaacaaat gtgtcacaaa gtaaggattc      180

tgatgtgtat atcacagaca aaactgtgct agacatgagg tctatggact tcaagagcaa      240

cagtgctgtg gcctggagca acaaatctga ctttgcatgt gcaaacgcct tcaacaacag      300

cattattcca gaagacacct tcttccccag cccaggtaag ggcagctttg gtgccttcgc      360

aggctgtttc cttgcttcag gaatggccag gttctgccca gagctctggt caatgatgtc      420

taaaactcct ctgattggtg gtctcggcct tatccattgc cac                        463


<210>  170
<211>  463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI67_TRAC_S4 3' (PAM containing) genomic seq

<400>  170
cctgggttgg ggcaaagagg gaaatgagat catgtcctaa ccctgatcct cttgtcccac       60

agatatccag aaccctgacc ctgccgtgta ccagctgaga gactctaaat ccagtgacaa      120

gtctgtctgc ctattcaccg attttgattc tcaaacaaat gtgtcacaaa gtaaggattc      180

tgatgtgtat atcacagaca aaactgtgct agacatgagg tctatggact tcaagagcaa      240

cagtgctgtg gcctggagca acaaatctga ctttgcatgt gcaaacgcct tcaacaacag      300

cattattcca gaagacacct tcttccccag cccaggtaag ggcagctttg gtgccttcgc      360

aggctgtttc cttgcttcag gaatggccag gttctgccca gagctctggt caatgatgtc      420

taaaactcct ctgattggtg gtctcggcct tatccattgc cac                        463


<210>  171
<211>  421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_CXCR4_S25 3' (PAM containing) genomic seq

<400>  171
ggaaatgaaa cttggggcga ggaccacggg tgcagacccc gttaccttct ccacccagga       60

aaatgccccg ctccctaacg tcccaaacgc gccaagtgat aaacacgagg atggcaagag      120

acccacacac cggaggagcg cccgcttggg ggaggaggtg ccgtttgttc attttctgac      180

actcccgccc aatatacccc aagcaccgaa gggccttcgt tttaagaccg cattctcttt      240

acccactaca agttgcttga agcccagaat ggtttgtatt taggcaggcg tgggaaaatt      300

aagtttttgc gctttaggag aatgagtctt tgcaacgccc ccgccctccc cccgtgatcc      360

tcccttctcc cctcttccct ccctgggcga aaaacttctt acaaaaagtt aatcactgcc      420

c                                                                      421


<210>  172
<211>  382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_CXCR4_S26 3' (PAM containing) genomic seq

<400>  172
cgttaccttc tccacccagg aaaatgcccc gctccctaac gtcccaaacg cgccaagtga       60

taaacacgag gatggcaaga gacccacaca ccggaggagc gcccgcttgg gggaggaggt      120

gccgtttgtt cattttctga cactcccgcc caatataccc caagcaccga agggccttcg      180

ttttaagacc gcattctctt tacccactac aagttgcttg aagcccagaa tggtttgtat      240

ttaggcaggc gtgggaaaat taagtttttg cgctttagga gaatgagtct ttgcaacgcc      300

cccgccctcc ccccgtgatc ctcccttctc ccctcttccc tccctgggcg aaaaacttct      360

tacaaaaagt taatcactgc cc                                               382


<210>  173
<211>  350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_g58_Ref 3' (PAM containing) genomic seq

<400>  173
agggccattg tctccctaac ccgagagcca tgggggtcca cttgcctgtg gtcacgtcag       60

gactccagcc tggcccaggc tctgcgtgtc cccgggtgcc ctcgccccgc ctattcctgg      120

agacaggccc gttggttccc ttcccctccc cttgtcctgg agccaggagg acgttggttc      180

ttgcgacagc cttggcccgg ccgttgcagc tggaacatcg tgggggagat gggaagagga      240

acggggcccg gagcccgggg ctgggtcctg ggaatccctt tcccgcagct gggactccag      300

ctcccctgcc agttcctcca ggcggaagcc ctcaggcttg gtcctcactc                 350


<210>  174
<211>  443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_g35 3' (PAM containing) genomic seq

<400>  174
ggcgtctgtt tcgtacgtgc cctgggtgtc cctctgctcc ccacccgctc ccagcccgga       60

ctgcagcaac aggcaccgtg gctagaccct aggagggact tcccaaccct gacaggcggc      120

gggcaggtgg gcagggcctc gcagtccagc ttccccacct tgtctgcctc cacaggggga      180

ctccggcagc cccttggtct gcaacgggct aatccacgga attgcctcct tcgtccgggg      240

aggctgcgcc tcagggctct accccgatgc ctttgccccg gtggcacagt ttgtaaactg      300

gatcgactct atcatccaac gctccgagga caacccctgt ccccaccccc gggacccgga      360

cccggccagc aggacccact gagaagggct gcccgggtca cctcagctgc ccacacccac      420

actctccagc atctggcaca ata                                              443


<210>  175
<211>  439
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_CXCR4_S6 3' (PAM containing) genomic seq

<400>  175
gatggcaaga gacccacaca ccggaggagc gcccgcttgg gggaggaggt gccgtttgtt       60

cattttctga cactcccgcc caatataccc caagcaccga agggccttcg ttttaagacc      120

gcattctctt tacccactac aagttgcttg aagcccagaa tggtttgtat ttaggcaggc      180

gtgggaaaat taagtttttg cgctttagga gaatgagtct ttgcaacgcc cccgccctcc      240

ccccgtgatc ctcccttctc ccctcttccc tccctgggcg aaaaacttct tacaaaaagt      300

taatcactgc ccctcctagc agcacccacc ccacccccca cgccgcctgg gagtggcctc      360

tttgtgtgta tttttttttt cctcctaagg aaggtttttt ttcttccctc tagtgggcgg      420

ggcagaggag ttagccaag                                                   439


<210>  176
<211>  422
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_CXCR4_S7 3' (PAM containing) genomic seq

<400>  176
ggaggaggtg ccgtttgttc attttctgac actcccgccc aatatacccc aagcaccgaa       60

gggccttcgt tttaagaccg cattctcttt acccactaca agttgcttga agcccagaat      120

ggtttgtatt taggcaggcg tgggaaaatt aagtttttgc gctttaggag aatgagtctt      180

tgcaacgccc ccgccctccc cccgtgatcc tcccttctcc cctcttccct ccctgggcga      240

aaaacttctt acaaaaagtt aatcactgcc cctcctagca gcacccaccc caccccccac      300

gccgcctggg agtggcctct ttgtgtgtat tttttttttc ctcctaagga aggttttttt      360

tcttccctct agtgggcggg gcagaggagt tagccaagat gtgactttga aaccctcagc      420

gt                                                                     422


<210>  177
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_PDCD1_S7 3' (PAM containing) genomic seq

<400>  177
cccttcctca cctctctcca tctctcagac tccccagaca ggccctggaa cccccccacc       60

ttctccccag ccctgctcgt ggtgaccgaa ggggacaacg ccaccttcac ctgcagcttc      120

tccaacacat cggagagctt cgtgctaaac tggtaccgca tgagccccag caaccagacg      180

gacaagctgg ccgccttccc cgaggaccgc agccagcccg gccaggactg ccgcttccgt      240

gtcacacaac tgcccaacgg gcgtgacttc cacatgagcg tggtcagggc ccggcgcaat      300

gacagcggca cctacctctg tggggccatc tccctggccc ccaaggcgca gatcaaagag      360

agcctgcggg cagagctcag ggtgacaggt gcggcctcgg aggccccggg gcaggggtga      420

gctgagccgg tcctg                                                       435


<210>  178
<211>  494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_PDCD1_S8 3' (PAM containing) genomic seq

<400>  178
ccctgctcgt ggtgaccgaa ggggacaacg ccaccttcac ctgcagcttc tccaacacat       60

cggagagctt cgtgctaaac tggtaccgca tgagccccag caaccagacg gacaagctgg      120

ccgccttccc cgaggaccgc agccagcccg gccaggactg ccgcttccgt gtcacacaac      180

tgcccaacgg gcgtgacttc cacatgagcg tggtcagggc ccggcgcaat gacagcggca      240

cctacctctg tggggccatc tccctggccc ccaaggcgca gatcaaagag agcctgcggg      300

cagagctcag ggtgacaggt gcggcctcgg aggccccggg gcaggggtga gctgagccgg      360

tcctggggtg ggtgtcccct cctgcacagg atcaggagct ccagggtcgt agggcaggga      420

ccccccagct ccagtccagg gctctgtcct gcacctgggg aatggtgacc ggcatctctg      480

tcctctagct ctgg                                                        494


<210>  179
<211>  463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_TRAC_S6 3' (PAM containing) genomic seq

<400>  179
cctgggttgg ggcaaagagg gaaatgagat catgtcctaa ccctgatcct cttgtcccac       60

agatatccag aaccctgacc ctgccgtgta ccagctgaga gactctaaat ccagtgacaa      120

gtctgtctgc ctattcaccg attttgattc tcaaacaaat gtgtcacaaa gtaaggattc      180

tgatgtgtat atcacagaca aaactgtgct agacatgagg tctatggact tcaagagcaa      240

cagtgctgtg gcctggagca acaaatctga ctttgcatgt gcaaacgcct tcaacaacag      300

cattattcca gaagacacct tcttccccag cccaggtaag ggcagctttg gtgccttcgc      360

aggctgtttc cttgcttcag gaatggccag gttctgccca gagctctggt caatgatgtc      420

taaaactcct ctgattggtg gtctcggcct tatccattgc cac                        463


<210>  180
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_TRAC_S7 3' (PAM containing) genomic seq

<400>  180
gtggcctgga gcaacaaatc tgactttgca tgtgcaaacg ccttcaacaa cagcattatt       60

ccagaagaca ccttcttccc cagcccaggt aagggcagct ttggtgcctt cgcaggctgt      120

ttccttgctt caggaatggc caggttctgc ccagagctct ggtcaatgat gtctaaaact      180

cctctgattg gtggtctcgg ccttatccat tgccaccaaa accctctttt tactaagaaa      240

cagtgagcct tgttctggca gtccagagaa tgacacggga aaaaagcaga tgaagagaag      300

gtggcaggag agggcacgtg gcccagcctc agtctctcca actgagttcc tgcctgcctg      360

cctttgctca gactgtttgc cccttactgc tcttctaggc ctcattctaa gccccttctc      420

caagttgcc                                                              429


<210>  181
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_PDCD1_S24

<400>  181
gtcgtctggg cggtgctaca ac                                                22


<210>  182
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_PDCD1_S25

<400>  182
tgctacaact gggctggcgg cc                                                22


<210>  183
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_TRAC_S21

<400>  183
actgtgctag acatgaggtc ta                                                22


<210>  184
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_TRAC_S24

<400>  184
ggccactttc aggaggagga tt                                                22


<210>  185
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_EMX_S2

<400>  185
cttctgtgaa tgttagaccc at                                                22


<210>  186
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_EMX_S3

<400>  186
acccatggga gcagctggtc ag                                                22


<210>  187
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9_rs070_1

<400>  187
ttagagtaga aatcgtctca tt                                                22


<210>  188
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9_rs070_2

<400>  188
gtagaaatcg tctcatttgg tg                                                22


<210>  189
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9_rs201_alt

<400>  189
tttaatctgg aagtaatcat at                                                22


<210>  190
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9_rs499_1

<400>  190
ggatctcttg ggtcatccac ag                                                22


<210>  191
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9_rs499_2

<400>  191
gtatttctat tactgtcctc tg                                                22


<210>  192
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9L_rs532_1

<400>  192
ctttttgatc attacattga ag                                                22


<210>  193
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9L_rs532_2

<400>  193
attacattga agtggtcaat ga                                                22


<210>  194
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S12

<400>  194
gtggaccagg tgaccaccgt ga                                                22


<210>  195
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S13

<400>  195
cacggtggtc acctggtcca cg                                                22


<210>  196
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S14

<400>  196
aggcaccttc acggtggtca cc                                                22


<210>  197
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S22

<400>  197
gactccaaaa cctgctctct cc                                                22


<210>  198
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S23

<400>  198
gttttggagt cctgatgtta ta                                                22


<210>  199
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S32

<400>  199
attgcaaaac tgatactgat tc                                                22


<210>  200
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S33

<400>  200
cagttttgca atctgaaaga cc                                                22


<210>  201
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S34

<400>  201
agttttgcaa tctgaaagac ct                                                22


<210>  202
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S38

<400>  202
acagcagcac caccacacgt tc                                                22


<210>  203
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S39

<400>  203
ttggttctgc cagaacgtgt gg                                                22


<210>  204
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S40

<400>  204
tttttggttc tgccagaacg tgtgg                                             25


<210>  205
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S49

<400>  205
acacaaaagc ctcagccttt ca                                                22


<210>  206
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S50

<400>  206
gctgaggctt ttgtgttgct ct                                                22


<210>  207
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S51

<400>  207
aggcttttgt gttgctcttg gt                                                22


<210>  208
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_EMX_S11

<400>  208
gctcccatgg gtctaacatt ca                                                22


<210>  209
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_EMX_S12

<400>  209
tacaaacggc agaagctgga gg                                                22


<210>  210
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_B2M_S8

<400>  210
cggcccgaat gctgtcagct tc                                                22


<210>  211
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI81_B2M_S9

<400>  211
actacactga attcaccccc ac                                                22


<210>  212
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9_rs070_1 3' (PAM containing) genomic seq

<400>  212
tggtgtggtt ttct                                                         14


<210>  213
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9_rs070_2 3' (PAM containing) genomic seq

<400>  213
tggttttctg ttctacata                                                    19


<210>  214
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9_rs201_alt 3' (PAM containing) genomic seq

<400>  214
tggcattcag agaactgtg                                                    19


<210>  215
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9_rs499_1 3' (PAM containing) genomic seq

<400>  215
aggacagtaa tagaaatac                                                    19


<210>  216
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9_rs499_2 3' (PAM containing) genomic seq

<400>  216
tggatgaccc aagagatc                                                     18


<210>  217
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9L_rs532_1 3' (PAM containing) genomic seq

<400>  217
tggtcaatga aggcagcc                                                     18


<210>  218
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_SAMD9L_rs532_2 3' (PAM containing) genomic seq

<400>  218
aggcagcctt actggtga                                                     18


<210>  219
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S12 3' (PAM containing) genomic seq

<400>  219
aggtgcctat gatgaag                                                      17


<210>  220
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S13 3' (PAM containing) genomic seq

<400>  220
tggaagtcct cttcctcggt                                                   20


<210>  221
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S14 3' (PAM containing) genomic seq

<400>  221
tggtccacgt ggaagtcctc t                                                 21


<210>  222
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S22 3' (PAM containing) genomic seq

<400>  222
tggcccttct atca                                                         14


<210>  223
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S23 3' (PAM containing) genomic seq

<400>  223
aggaacagct tgggagg                                                      17


<210>  224
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S32 3' (PAM containing) genomic seq

<400>  224
tgggacacta gagtcgtgt                                                    19


<210>  225
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S33 3' (PAM containing) genomic seq

<400>  225
tgggttcaaa tcctgcct                                                     18


<210>  226
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S34 3' (PAM containing) genomic seq

<400>  226
gggttcaaat cctgcctc                                                     18


<210>  227
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S38 3' (PAM containing) genomic seq

<400>  227
tggcagaacc aaaaaggaac                                                   20


<210>  228
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S39 3' (PAM containing) genomic seq

<400>  228
tggtgctgct gtccctgccc tgg                                               23


<210>  229
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S40 3' (PAM containing) genomic seq

<400>  229
tggtggtgct gctgtccctg                                                   20


<210>  230
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S49 3' (PAM containing) genomic seq

<400>  230
aggagcactt ggggtgtttg                                                   20


<210>  231
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S50 3' (PAM containing) genomic seq

<400>  231
tggttggatt attcacaggc                                                   20


<210>  232
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI79_Serpina_S51 3' (PAM containing) genomic seq

<400>  232
tggattattc acaggc                                                       16


<210>  233
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ELANE g35 19nt

<400>  233
guccgggcug ggagcgggu                                                    19


<210>  234
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ELANE g35 20nt

<400>  234
aguccgggcu gggagcgggu                                                   20


<210>  235
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ELANE g35 21nt

<400>  235
caguccgggc ugggagcggg u                                                 21


<210>  236
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ELANE g35 22nt

<400>  236
gcaguccggg cugggagcgg gu                                                22


<210>  237
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ELANE g35 23nt

<400>  237
ugcaguccgg gcugggagcg ggu                                               23


<210>  238
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ELANE g35 24nt

<400>  238
cugcaguccg ggcugggagc gggu                                              24


<210>  239
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ELANE g35 25nt

<400>  239
gcugcagucc gggcugggag cgggu                                             25


<210>  240
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  ELANE g35 26nt

<400>  240
ugcugcaguc cgggcuggga gcgggu                                            26


<210>  241
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-79 scaffold sequence

<400>  241
guugccgcug gagaaaucca guuguuaaca agcagcuuga cugcaccaaa uaaggcgggg       60

gcugcggccc ucgcuuuuuu                                                   80


<210>  242
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T1 sequence

<400>  242
ggtgcggttc accagggtgt cg                                                22


<210>  243
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2 sequence

<400>  243
ggaagagcag agccttggtc tc                                                22


