                         SEQUENCE LISTING

<110>  University of Utah Research Foundation
 
<120>  CONFORMATIONALLY-CONSTRAINED Alpha-RGIA ANALOGUES

<130>  00846-U6996.PCT

<150>  63/034,395
<151>  2020-06-03

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Gly Cys Cys Ser Asp Pro Arg Cys Arg Tyr Arg Cys Arg 
1               5                   10              


<210>  2
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-Iodo-tyrosine

<400>  2

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr 
1               5                   10              


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (10)..(12)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (14)..(15)
<223>  Any Amino acid other than Cysteine

<400>  3

Xaa Xaa Cys Cys Xaa Asp Pro Arg Cys Xaa Xaa Xaa Cys Xaa Xaa 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  E or D

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (10)..(12)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  K or Dap

<400>  4

Xaa Xaa Cys Cys Xaa Asp Pro Arg Cys Xaa Xaa Xaa Cys Xaa Xaa 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  E or D

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (10)..(11)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  K or Dap

<400>  5

Xaa Xaa Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr Xaa 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  E or D

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  G or bA

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  R or (Cit)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Y or (iY)

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  K or Dap

<400>  6

Xaa Xaa Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr Xaa 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  L-2,3-diaminopropionic acid

<400>  7

Asp Gly Cys Cys Thr Asp Pro Arg Cys Xaa Tyr Gln Cys Tyr Xaa 
1               5                   10                  15  


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Citrulline

<400>  8

Asp Gly Cys Cys Thr Asp Pro Arg Cys Xaa Tyr Gln Cys Tyr Lys 
1               5                   10                  15  


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Citrulline

<400>  9

Glu Gly Cys Cys Thr Asp Pro Arg Cys Xaa Tyr Gln Cys Tyr Lys 
1               5                   10                  15  


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  beta-alanine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Citrulline

<400>  10

Glu Xaa Cys Cys Thr Asp Pro Arg Cys Xaa Tyr Gln Cys Tyr Lys 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  3-Iodo-tyrosine

<400>  11

Glu Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr Lys 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  3-Iodo-tyrosine

<400>  12

Glu Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Tyr Lys 
1               5                   10                  15  


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (9)..(11)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Any Amino acid other than Cysteine

<400>  13

Xaa Cys Cys Xaa Asp Pro Arg Cys Xaa Xaa Xaa Cys Xaa 
1               5                   10              


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  (Cit) or positive amino acid (His, Arg, or Lys)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  aromatic amino acid (Phe, Tyr, or Trp)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  positive amino acid (His, Arg, or Lys)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  aromatic amino acid (Phe, Tyr, or Trp)

<400>  14

Xaa Cys Cys Xaa Asp Pro Arg Cys Xaa Xaa Xaa Cys Xaa 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (9)..(10)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Any Amino acid other than Cysteine

<400>  15

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Xaa 
1               5                   10              


<210>  16
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline or Arg

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  iY or Y

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  bhY, Y, or bA

<400>  16

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Xaa 
1               5                   10              


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-Iodo-tyrosine

<400>  17

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-Iodo-tyrosine

<400>  18

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr 
1               5                   10              


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-Iodo-tyrosine

<400>  19

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Tyr 
1               5                   10              


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (9)..(11)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  Any Amino acid other than Cysteine

<400>  20

Xaa Cys Cys Xaa Asp Pro Arg Cys Xaa Xaa Xaa Cys Xaa Xaa 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  (Cit) or positive amino acid (His, Arg, or Lys)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  aromatic amino acid (Phe, Tyr, or Trp)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  positive amino acid (His, Arg, or Lys)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  aromatic amino acid (Phe, Tyr, or Trp)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Any Amino acid other than Cysteine

<400>  21

Xaa Cys Cys Xaa Asp Pro Arg Cys Xaa Xaa Xaa Cys Xaa Xaa 
1               5                   10                  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (9)..(10)
<223>  Any Amino acid other than Cysteine

<220>
<221>  MISC_FEATURE
<222>  (13)..(14)
<223>  Any Amino acid other than Cysteine

<400>  22

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Xaa Xaa 
1               5                   10                  


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Citrulline or Arg

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  iY or Y

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  bhY, Y, or bA

<400>  23

Gly Cys Cys Thr Asp Pro Arg Cys Xaa Xaa Gln Cys Xaa Arg 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-Iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  L-beta-homo-tyrosine

<400>  24

Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Arg 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  3-Iodo-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  beta-alanine

<400>  25

Gly Cys Cys Thr Asp Pro Arg Cys Arg Xaa Gln Cys Xaa Arg 
1               5                   10                  


