
                                SEQUENCE LISTING

<110> Vir Biotechnology, Inc.
      Humabs BioMed SA
      University of Washington

<120> STRUCTURE-GUIDED IMMUNOTHERAPY AGAINST 
      SARS-COV-2

<130> 930585.412WO

<140> PCT
<141> 2021-06-03

<150> US 63/166,874
<151> 2021-03-26

<150> US 63/078,157
<151> 2020-09-14

<150> US 63/070,803
<151> 2020-08-26

<150> US 63/066,093
<151> 2020-08-14

<150> US 63/058,368
<151> 2020-07-29

<150> US 63/055,861
<151> 2020-07-23

<150> US 63/034,326
<151> 2020-06-03

<160> 170

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 29902
<212> DNA
<213> betacoronavirus SARS coronavirus 2

<400> 1
attaaaggtt tataccttcc caggtaacaa accaaccaac tttcgatctc ttgtagatct      60
gttctctaaa cgaactttaa aatctgtgtg gctgtcactc ggctgcatgc ttagtgcact     120
cacgcagtat aattaataac taattactgt cgttgacagg acacgagtaa ctcgtctatc     180
ttctgcaggc tgcttacggt ttcgtccgtg ttgcagccga tcatcagcac atctaggttt     240
cgtccgggtg tgaccgaaag gtaagatgga gagccttgtc cctggtttca acgagaaaac     300
acacgtccaa ctcagtttgc ctgttttaca ggttcgcgac gtgctcgtac gtggctttgg     360
agactccgtg gaggaggtct tatcagaggc cgtcaacatc ttaaagatgg cacttgtggc     420
ttagtagaag ttgaaaaagg cgttttgcct caacttgaac agccctatgt gttcatcaaa     480
cgttcggatg ctcgaactgc acctcatggt catgttatgg ttgagctggt agcagaactc     540
gaaggcattc agtacggtcg tagtggtgag acacttggtg tccttgtccc tcatgtgggc     600
gaaataccag tggcttaccg caaggttctt cttcgtaaga acggtaataa aggagctggt     660
ggccatagtt acggcgccga tctaaagtca tttgacttag gcgacgagct tggcactgat     720
ccttatgaag attttcaaga aaactggaac actaaacata gcagtggtgt tacccgtgaa     780
ctcatgcgtg agcttaacgg aggggcatac actcgctatg tcgataacaa cttctgtggc     840
cctgatggct accctcttga gtgcattaaa gaccttctag cacgtgctgg taaagcttca     900
tgcactttgt ccgaacaact ggactttatt gacactaaga ggggtgtata ctgctgccgt     960
gaacatgagc atgaaattgc ttggtacacg gaacgttctg aaaagagcta tgaattgcag    1020
acaccttttg aaattaaatt ggcaaagaaa tttgacacct tcaatgggga atgtccaaat    1080
tttgtatttc ccttaaattc cataatcaag actattcaac caagggttga aaagaaaaag    1140
cttgatggct ttatgggtag aattcgatct gtctatccag ttgcgtcacc aaatgaatgc    1200
aaccaaatgt gcctttcaac tctcatgaag tgtgatcatt gtggtgaaac ttcatggcag    1260
acgggcgatt ttgttaaagc cacttgcgaa ttttgtggca ctgagaattt gactaaagaa    1320
ggtgccacta cttgtggtta cttaccccaa aatgctgttg ttaaaattta ttgtccagca    1380
tgtcacaatt cagaagtagg acctgagcat agtcttgccg aataccataa tgaatctggc    1440
ttgaaaacca ttcttcgtaa gggtggtcgc actattgcct ttggaggctg tgtgttctct    1500
tatgttggtt gccataacaa gtgtgcctat tgggttccac gtgctagcgc taacataggt    1560
tgtaaccata caggtgttgt tggagaaggt tccgaaggtc ttaatgacaa ccttcttgaa    1620
atactccaaa aagagaaagt caacatcaat attgttggtg actttaaact taatgaagag    1680
atcgccatta ttttggcatc tttttctgct tccacaagtg cttttgtgga aactgtgaaa    1740
ggtttggatt ataaagcatt caaacaaatt gttgaatcct gtggtaattt taaagttaca    1800
aaaggaaaag ctaaaaaagg tgcctggaat attggtgaac agaaatcaat actgagtcct    1860
ctttatgcat ttgcatcaga ggctgctcgt gttgtacgat caattttctc ccgcactctt    1920
gaaactgctc aaaattctgt gcgtgtttta cagaaggccg ctataacaat actagatgga    1980
atttcacagt attcactgag actcattgat gctatgatgt tcacatctga tttggctact    2040
aacaatctag ttgtaatggc ctacattaca ggtggtgttg ttcagttgac ttcgcagtgg    2100
ctaactaaca tctttggcac tgtttatgaa aaactcaaac ccgtccttga ttggcttgaa    2160
gagaagttta aggaaggtgt agagtttctt agagacggtt gggaaattgt taaatttatc    2220
tcaacctgtg cttgtgaaat tgtcggtgga caaattgtca cctgtgcaaa ggaaattaag    2280
gagagtgttc agacattctt taagcttgta aataaatttt tggctttgtg tgctgactct    2340
atcattattg gtggagctaa acttaaagcc ttgaatttag gtgaaacatt tgtcacgcac    2400
tcaaagggat tgtacagaaa gtgtgttaaa tccagagaag aaactggcct actcatgcct    2460
ctaaaagccc caaaagaaat tatcttctta gagggagaaa cacttcccac agaagtgtta    2520
acagaggaag ttgtcttgaa aactggtgat ttacaaccat tagaacaacc tactagtgaa    2580
gctgttgaag ctccattggt tggtacacca gtttgtatta acgggcttat gttgctcgaa    2640
atcaaagaca cagaaaagta ctgtgccctt gcacctaata tgatggtaac aaacaatacc    2700
ttcacactca aaggcggtgc accaacaaag gttacttttg gtgatgacac tgtgatagaa    2760
gtgcaaggtt acaagagtgt gaatatcact tttgaacttg atgaaaggat tgataaagta    2820
cttaatgaga agtgctctgc ctatacagtt gaactcggta cagaagtaaa tgagttcgcc    2880
tgtgttgtgg cagatgctgt cataaaaact ttgcaaccag tatctgaatt acttacacca    2940
ctgggcattg atttagatga gtggagtatg gctacatact acttatttga tgagtctggt    3000
gagtttaaat tggcttcaca tatgtattgt tctttctacc ctccagatga ggatgaagaa    3060
gaaggtgatt gtgaagaaga agagtttgag ccatcaactc aatatgagta tggtactgaa    3120
gatgattacc aaggtaaacc tttggaattt ggtgccactt ctgctgctct tcaacctgaa    3180
gaagagcaag aagaagattg gttagatgat gatagtcaac aaactgttgg tcaacaagac    3240
ggcagtgagg acaatcagac aactactatt caaacaattg ttgaggttca acctcaatta    3300
gagatggaac ttacaccagt tgttcagact attgaagtga atagttttag tggttattta    3360
aaacttactg acaatgtata cattaaaaat gcagacattg tggaagaagc taaaaaggta    3420
aaaccaacag tggttgttaa tgcagccaat gtttacctta aacatggagg aggtgttgca    3480
ggagccttaa ataaggctac taacaatgcc atgcaagttg aatctgatga ttacatagct    3540
actaatggac cacttaaagt gggtggtagt tgtgttttaa gcggacacaa tcttgctaaa    3600
cactgtcttc atgttgtcgg cccaaatgtt aacaaaggtg aagacattca acttcttaag    3660
agtgcttatg aaaattttaa tcagcacgaa gttctacttg caccattatt atcagctggt    3720
atttttggtg ctgaccctat acattcttta agagtttgtg tagatactgt tcgcacaaat    3780
gtctacttag ctgtctttga taaaaatctc tatgacaaac ttgtttcaag ctttttggaa    3840
atgaagagtg aaaagcaagt tgaacaaaag atcgctgaga ttcctaaaga ggaagttaag    3900
ccatttataa ctgaaagtaa accttcagtt gaacagagaa aacaagatga taagaaaatc    3960
aaagcttgtg ttgaagaagt tacaacaact ctggaagaaa ctaagttcct cacagaaaac    4020
ttgttacttt atattgacat taatggcaat cttcatccag attctgccac tcttgttagt    4080
gacattgaca tcactttctt aaagaaagat gctccatata tagtgggtga tgttgttcaa    4140
gagggtgttt taactgctgt ggttatacct actaaaaagg ctggtggcac tactgaaatg    4200
ctagcgaaag ctttgagaaa agtgccaaca gacaattata taaccactta cccgggtcag    4260
ggtttaaatg gttacactgt agaggaggca aagacagtgc ttaaaaagtg taaaagtgcc    4320
ttttacattc taccatctat tatctctaat gagaagcaag aaattcttgg aactgtttct    4380
tggaatttgc gagaaatgct tgcacatgca gaagaaacac gcaaattaat gcctgtctgt    4440
gtggaaacta aagccatagt ttcaactata cagcgtaaat ataagggtat taaaatacaa    4500
gagggtgtgg ttgattatgg tgctagattt tacttttaca ccagtaaaac aactgtagcg    4560
tcacttatca acacacttaa cgatctaaat gaaactcttg ttacaatgcc acttggctat    4620
gtaacacatg gcttaaattt ggaagaagct gctcggtata tgagatctct caaagtgcca    4680
gctacagttt ctgtttcttc acctgatgct gttacagcgt ataatggtta tcttacttct    4740
tcttctaaaa cacctgaaga acattttatt gaaaccatct cacttgctgg ttcctataaa    4800
gattggtcct attctggaca atctacacaa ctaggtatag aatttcttaa gagaggtgat    4860
aaaagtgtat attacactag taatcctacc acattccacc tagatggtga agttatcacc    4920
tttgacaatc ttaagacact tctttctttg agagaagtga ggactattaa ggtgtttaca    4980
acagtagaca acattaacct ccacacgcaa gttgtggaca tgtcaatgac atatggacaa    5040
cagtttggtc caacttattt ggatggagct gatgttacta aaataaaacc tcataattca    5100
catgaaggta aaacatttta tgttttacct aatgatgaca ctctacgtgt tgaggctttt    5160
gagtactacc acacaactga tcctagtttt ctgggtaggt acatgtcagc attaaatcac    5220
actaaaaagt ggaaataccc acaagttaat ggtttaactt ctattaaatg ggcagataac    5280
aactgttatc ttgccactgc attgttaaca ctccaacaaa tagagttgaa gtttaatcca    5340
cctgctctac aagatgctta ttacagagca agggctggtg aagctgctaa cttttgtgca    5400
cttatcttag cctactgtaa taagacagta ggtgagttag gtgatgttag agaaacaatg    5460
agttacttgt ttcaacatgc caatttagat tcttgcaaaa gagtcttgaa cgtggtgtgt    5520
aaaacttgtg gacaacagca gacaaccctt aagggtgtag aagctgttat gtacatgggc    5580
acactttctt atgaacaatt taagaaaggt gttcagatac cttgtacgtg tggtaaacaa    5640
gctacaaaat atctagtaca acaggagtca ccttttgtta tgatgtcagc accacctgct    5700
cagtatgaac ttaagcatgg tacatttact tgtgctagtg agtacactgg taattaccag    5760
tgtggtcact ataaacatat aacttctaaa gaaactttgt attgcataga cggtgcttta    5820
cttacaaagt cctcagaata caaaggtcct attacggatg ttttctacaa agaaaacagt    5880
tacacaacaa ccataaaacc agttacttat aaattggatg gtgttgtttg tacagaaatt    5940
gaccctaagt tggacaatta ttataagaaa gacaattctt atttcacaga gcaaccaatt    6000
gatcttgtac caaaccaacc atatccaaac gcaagcttcg ataattttaa gtttgtatgt    6060
gataatatca aatttgctga tgatttaaac cagttaactg gttataagaa acctgcttca    6120
agagagctta aagttacatt tttccctgac ttaaatggtg atgtggtggc tattgattat    6180
aaacactaca caccctcttt taagaaagga gctaaattgt tacataaacc tattgtttgg    6240
catgttaaca atgcaactaa taaagccacg tataaaccaa atacctggtg tatacgttgt    6300
ctttggagca caaaaccagt tgaaacatca aattcgtttg atgtactgaa gtcagaggac    6360
gcgcagggaa tggataatct tgcctgcgaa gatctaaaac cagtctctga agaagtagtg    6420
gaaaatccta ccatacagaa agacgttctt gagtgtaatg tgaaaactac cgaagttgta    6480
ggagacatta tacttaaacc agcaaataat agtttaaaaa ttacagaaga ggttggccac    6540
acagatctaa tggctgctta tgtagacaat tctagtctta ctattaagaa acctaatgaa    6600
ttatctagag tattaggttt gaaaaccctt gctactcatg gtttagctgc tgttaatagt    6660
gtcccttggg atactatagc taattatgct aagccttttc ttaacaaagt tgttagtaca    6720
actactaaca tagttacacg gtgtttaaac cgtgtttgta ctaattatat gccttatttc    6780
tttactttat tgctacaatt gtgtactttt actagaagta caaattctag aattaaagca    6840
tctatgccga ctactatagc aaagaatact gttaagagtg tcggtaaatt ttgtctagag    6900
gcttcattta attatttgaa gtcacctaat ttttctaaac tgataaatat tataatttgg    6960
tttttactat taagtgtttg cctaggttct ttaatctact caaccgctgc tttaggtgtt    7020
ttaatgtcta atttaggcat gccttcttac tgtactggtt acagagaagg ctatttgaac    7080
tctactaatg tcactattgc aacctactgt actggttcta taccttgtag tgtttgtctt    7140
agtggtttag attctttaga cacctatcct tctttagaaa ctatacaaat taccatttca    7200
tcttttaaat gggatttaac tgcttttggc ttagttgcag agtggttttt ggcatatatt    7260
cttttcacta ggtttttcta tgtacttgga ttggctgcaa tcatgcaatt gtttttcagc    7320
tattttgcag tacattttat tagtaattct tggcttatgt ggttaataat taatcttgta    7380
caaatggccc cgatttcagc tatggttaga atgtacatct tctttgcatc attttattat    7440
gtatggaaaa gttatgtgca tgttgtagac ggttgtaatt catcaacttg tatgatgtgt    7500
tacaaacgta atagagcaac aagagtcgaa tgtacaacta ttgttaatgg tgttagaagg    7560
tccttttatg tctatgctaa tggaggtaaa ggcttttgca aactacacaa ttggaattgt    7620
gttaattgtg atacattctg tgctggtagt acatttatta gtgatgaagt tgcgagagac    7680
ttgtcactac agtttaaaag accaataaat cctactgacc agtcttctta catcgttgat    7740
agtgttacag tgaagaatgg ttccatccat ctttactttg ataaagctgg tcaaaagact    7800
tatgaaagac attctctctc tcattttgtt aacttagaca acctgagagc taataacact    7860
aaaggttcat tgcctattaa tgttatagtt tttgatggta aatcaaaatg tgaagaatca    7920
tctgcaaaat cagcgtctgt ttactacagt cagcttatgt gtcaacctat actgttacta    7980
gatcaggcat tagtgtctga tgttggtgat agtgcggaag ttgcagttaa aatgtttgat    8040
gcttacgtta atacgttttc atcaactttt aacgtaccaa tggaaaaact caaaacacta    8100
gttgcaactg cagaagctga acttgcaaag aatgtgtcct tagacaatgt cttatctact    8160
tttatttcag cagctcggca agggtttgtt gattcagatg tagaaactaa agatgttgtt    8220
gaatgtctta aattgtcaca tcaatctgac atagaagtta ctggcgatag ttgtaataac    8280
tatatgctca cctataacaa agttgaaaac atgacacccc gtgaccttgg tgcttgtatt    8340
gactgtagtg cgcgtcatat taatgcgcag gtagcaaaaa gtcacaacat tgctttgata    8400
tggaacgtta aagatttcat gtcattgtct gaacaactac gaaaacaaat acgtagtgct    8460
gctaaaaaga ataacttacc ttttaagttg acatgtgcaa ctactagaca agttgttaat    8520
gttgtaacaa caaagatagc acttaagggt ggtaaaattg ttaataattg gttgaagcag    8580
ttaattaaag ttacacttgt gttccttttt gttgctgcta ttttctattt aataacacct    8640
gttcatgtca tgtctaaaca tactgacttt tcaagtgaaa tcataggata caaggctatt    8700
gatggtggtg tcactcgtga catagcatct acagatactt gttttgctaa caaacatgct    8760
gattttgaca catggtttag ccagcgtggt ggtagttata ctaatgacaa agcttgccca    8820
ttgattgctg cagtcataac aagagaagtg ggttttgtcg tgcctggttt gcctggcacg    8880
atattacgca caactaatgg tgactttttg catttcttac ctagagtttt tagtgcagtt    8940
ggtaacatct gttacacacc atcaaaactt atagagtaca ctgactttgc aacatcagct    9000
tgtgttttgg ctgctgaatg tacaattttt aaagatgctt ctggtaagcc agtaccatat    9060
tgttatgata ccaatgtact agaaggttct gttgcttatg aaagtttacg ccctgacaca    9120
cgttatgtgc tcatggatgg ctctattatt caatttccta acacctacct tgaaggttct    9180
gttagagtgg taacaacttt tgattctgag tactgtaggc acggcacttg tgaaagatca    9240
gaagctggtg tttgtgtatc tactagtggt agatgggtac ttaacaatga ttattacaga    9300
tctttaccag gagttttctg tggtgtagat gctgtaaatt tacttactaa tatgtttaca    9360
ccactaattc aacctattgg tgctttggac atatcagcat ctatagtagc tggtggtatt    9420
gtagctatcg tagtaacatg ccttgcctac tattttatga ggtttagaag agcttttggt    9480
gaatacagtc atgtagttgc ctttaatact ttactattcc ttatgtcatt cactgtactc    9540
tgtttaacac cagtttactc attcttacct ggtgtttatt ctgttattta cttgtacttg    9600
acattttatc ttactaatga tgtttctttt ttagcacata ttcagtggat ggttatgttc    9660
acacctttag tacctttctg gataacaatt gcttatatca tttgtatttc cacaaagcat    9720
ttctattggt tctttagtaa ttacctaaag agacgtgtag tctttaatgg tgtttccttt    9780
agtacttttg aagaagctgc gctgtgcacc tttttgttaa ataaagaaat gtatctaaag    9840
ttgcgtagtg atgtgctatt acctcttacg caatataata gatacttagc tctttataat    9900
aagtacaagt attttagtgg agcaatggat acaactagct acagagaagc tgcttgttgt    9960
catctcgcaa aggctctcaa tgacttcagt aactcaggtt ctgatgttct ttaccaacca   10020
ccacaaacct ctatcacctc agctgttttg cagagtggtt ttagaaaaat ggcattccca   10080
tctggtaaag ttgagggttg tatggtacaa gtaacttgtg gtacaactac acttaacggt   10140
ctttggcttg atgacgtagt ttactgtcca agacatgtga tctgcacctc tgaagacatg   10200
cttaacccta attatgaaga tttactcatt cgtaagtcta atcataattt cttggtacag   10260
gctggtaatg ttcaactcag ggttattgga cattctatgc aaaattgtgt acttaagctt   10320
aaggttgata cagccaatcc taagacacct aagtataagt ttgttcgcat tcaaccagga   10380
cagacttttt cagtgttagc ttgttacaat ggttcaccat ctggtgttta ccaatgtgct   10440
atgaggccca atttcactat taagggttca ttccttaatg gttcatgtgg tagtgttggt   10500
tttaacatag attatgactg tgtctctttt tgttacatgc accatatgga attaccaact   10560
ggagttcatg ctggcacaga cttagaaggt aacttttatg gaccttttgt tgacaggcaa   10620
acagcacaag cagctggtac ggacacaact attacagtta atgttttagc ttggttgtac   10680
gctgctgtta taaatggaga caggtggttt ctcaatcgat ttaccacaac tcttaatgac   10740
tttaaccttg tggctatgaa gtacaattat gaacctctaa cacaagacca tgttgacata   10800
ctaggacctc tttctgctca aactggaatt gccgttttag atatgtgtgc ttcattaaaa   10860
gaattactgc aaaatggtat gaatggacgt accatattgg gtagtgcttt attagaagat   10920
gaatttacac cttttgatgt tgttagacaa tgctcaggtg ttactttcca aagtgcagtg   10980
aaaagaacaa tcaagggtac acaccactgg ttgttactca caattttgac ttcactttta   11040
gttttagtcc agagtactca atggtctttg ttcttttttt tgtatgaaaa tgccttttta   11100
ccttttgcta tgggtattat tgctatgtct gcttttgcaa tgatgtttgt caaacataag   11160
catgcatttc tctgtttgtt tttgttacct tctcttgcca ctgtagctta ttttaatatg   11220
gtctatatgc ctgctagttg ggtgatgcgt attatgacat ggttggatat ggttgatact   11280
agtttgtctg gttttaagct aaaagactgt gttatgtatg catcagctgt agtgttacta   11340
atccttatga cagcaagaac tgtgtatgat gatggtgcta ggagagtgtg gacacttatg   11400
aatgtcttga cactcgttta taaagtttat tatggtaatg ctttagatca agccatttcc   11460
atgtgggctc ttataatctc tgttacttct aactactcag gtgtagttac aactgtcatg   11520
tttttggcca gaggtattgt ttttatgtgt gttgagtatt gccctatttt cttcataact   11580
ggtaatacac ttcagtgtat aatgctagtt tattgtttct taggctattt ttgtacttgt   11640
tactttggcc tcttttgttt actcaaccgc tactttagac tgactcttgg tgtttatgat   11700
tacttagttt ctacacagga gtttagatat atgaattcac agggactact cccacccaag   11760
aatagcatag atgccttcaa actcaacatt aaattgttgg gtgttggtgg caaaccttgt   11820
atcaaagtag ccactgtaca gtctaaaatg tcagatgtaa agtgcacatc agtagtctta   11880
ctctcagttt tgcaacaact cagagtagaa tcatcatcta aattgtgggc tcaatgtgtc   11940
cagttacaca atgacattct cttagctaaa gatactactg aagcctttga aaaaatggtt   12000
tcactacttt ctgttttgct ttccatgcag ggtgctgtag acataaacaa gctttgtgaa   12060
gaaatgctgg acaacagggc aaccttacaa gctatagcct cagagtttag ttcccttcca   12120
tcatatgcag cttttgctac tgctcaagaa gcttatgagc aggctgttgc taatggtgat   12180
tctgaagttg ttcttaaaaa gttgaagaag tctttgaatg tggctaaatc tgaatttgac   12240
cgtgatgcag ccatgcaacg taagttggaa aagatggctg atcaagctat gacccaaatg   12300
tataaacagg ctagatctga ggacaagagg gcaaaagtta ctagtgctat gcagacaatg   12360
cttttcacta tgcttagaaa gttggataat gatgcactca acaacattat caacaatgca   12420
agagatggtt gtgttccctt gaacataata cctcttacaa cagcagccaa actaatggtt   12480
gtcataccag actataacac atataaaaat acgtgtgatg gtacaacatt tacttatgca   12540
tcagcattgt gggaaatcca acaggttgta gatgcagata gtaaaattgt tcaacttagt   12600
gaaattagta tggacaattc acctaattta gcatggcctc ttattgtaac agctttaagg   12660
gccaattctg ctgtcaaatt acagaataat gagcttagtc ctgttgcact acgacagatg   12720
tcttgtgctg ccggtactac acaaactgct tgcactgatg acaatgcgtt agcttactac   12780
aacacaacaa agggaggtag gtttgtactt gcactgttat ccgatttaca ggatttgaaa   12840
tgggctagat tccctaagag tgatggaact ggtactatct atacagaact ggaaccacct   12900
tgtaggtttg ttacagacac acctaaaggt cctaaagtga agtatttata ctttattaaa   12960
ggattaaaca acctaaatag aggtatggta cttggtagtt tagctgccac agtacgtcta   13020
caagctggta atgcaacaga agtgcctgcc aattcaactg tattatcttt ctgtgctttt   13080
gctgtagatg ctgctaaagc ttacaaagat tatctagcta gtgggggaca accaatcact   13140
aattgtgtta agatgttgtg tacacacact ggtactggtc aggcaataac agttacaccg   13200
gaagccaata tggatcaaga atcctttggt ggtgcatcgt gttgtctgta ctgccgttgc   13260
cacatagatc atccaaatcc taaaggattt tgtgacttaa aaggtaagta tgtacaaata   13320
cctacaactt gtgctaatga ccctgtgggt tttacactta aaaacacagt ctgtaccgtc   13380
tgcggtatgt ggaaaggtta tggctgtagt tgtgatcaac tccgcgaacc catgcttcag   13440
tcagctgatg cacaatcgtt tttaaacggg tttgcggtgt aagtgcagcc cgtcttacac   13500
cgtgcggcac aggcactagt actgatgtcg tatacagggc ttttgacatc tacaatgata   13560
aagtagctgg ttttgctaaa ttcctaaaaa ctaattgttg tcgcttccaa gaaaaggacg   13620
aagatgacaa tttaattgat tcttactttg tagttaagag acacactttc tctaactacc   13680
aacatgaaga aacaatttat aatttactta aggattgtcc agctgttgct aaacatgact   13740
tctttaagtt tagaatagac ggtgacatgg taccacatat atcacgtcaa cgtcttacta   13800
aatacacaat ggcagacctc gtctatgctt taaggcattt tgatgaaggt aattgtgaca   13860
cattaaaaga aatacttgtc acatacaatt gttgtgatga tgattatttc aataaaaagg   13920
actggtatga ttttgtagaa aacccagata tattacgcgt atacgccaac ttaggtgaac   13980
gtgtacgcca agctttgtta aaaacagtac aattctgtga tgccatgcga aatgctggta   14040
ttgttggtgt actgacatta gataatcaag atctcaatgg taactggtat gatttcggtg   14100
atttcataca aaccacgcca ggtagtggag ttcctgttgt agattcttat tattcattgt   14160
taatgcctat attaaccttg accagggctt taactgcaga gtcacatgtt gacactgact   14220
taacaaagcc ttacattaag tgggatttgt taaaatatga cttcacggaa gagaggttaa   14280
aactctttga ccgttatttt aaatattggg atcagacata ccacccaaat tgtgttaact   14340
gtttggatga cagatgcatt ctgcattgtg caaactttaa tgttttattc tctacagtgt   14400
tcccacctac aagttttgga ccactagtga gaaaaatatt tgttgatggt gttccatttg   14460
tagtttcaac tggataccac ttcagagagc taggtgttgt acataatcag gatgtaaact   14520
tacatagctc tagacttagt tttaaggaat tacttgtgta tgctgctgac cctgctatgc   14580
acgctgcttc tggtaatcta ttactagata aacgcactac gtgcttttca gtagctgcac   14640
ttactaacaa tgttgctttt caaactgtca aacccggtaa ttttaacaaa gacttctatg   14700
actttgctgt gtctaagggt ttctttaagg aaggaagttc tgttgaatta aaacacttct   14760
tctttgctca ggatggtaat gctgctatca gcgattatga ctactatcgt tataatctac   14820
caacaatgtg tgatatcaga caactactat ttgtagttga agttgttgat aagtactttg   14880
attgttacga tggtggctgt attaatgcta accaagtcat cgtcaacaac ctagacaaat   14940
cagctggttt tccatttaat aaatggggta aggctagact ttattatgat tcaatgagtt   15000
atgaggatca agatgcactt ttcgcatata caaaacgtaa tgtcatccct actataactc   15060
aaatgaatct taagtatgcc attagtgcaa agaatagagc tcgcaccgta gctggtgtct   15120
ctatctgtag tactatgacc aatagacagt ttcatcaaaa attattgaaa tcaatagccg   15180
ccactagagg agctactgta gtaattggaa caagcaaatt ctatggtggt tggcacaaca   15240
tgttaaaaac tgtttatagt gatgtagaaa accctcacct tatgggttgg gattatccta   15300
aatgtgatag agccatgcct aacatgctta gaattatggc ctcacttgtt cttgctcgca   15360
aacatacaac gtgttgtagc ttgtcacacc gtttctatag attagctaat gagtgtgctc   15420
aagtattgag tgaaatggtc atgtgtggcg gttcactata tgttaaacca ggtggaacct   15480
catcaggaga tgccacaact gcttatgcta atagtgtttt taacatttgt caagctgtca   15540
cggccaatgt taatgcactt ttatctactg atggtaacaa aattgccgat aagtatgtcc   15600
gcaatttaca acacagactt tatgagtgtc tctatagaaa tagagatgtt gacacagact   15660
ttgtgaatga gttttacgca tatttgcgta aacatttctc aatgatgata ctctctgacg   15720
atgctgttgt gtgtttcaat agcacttatg catctcaagg tctagtggct agcataaaga   15780
actttaagtc agttctttat tatcaaaaca atgtttttat gtctgaagca aaatgttgga   15840
ctgagactga ccttactaaa ggacctcatg aattttgctc tcaacataca atgctagtta   15900
aacagggtga tgattatgtg taccttcctt acccagatcc atcaagaatc ctaggggccg   15960
gctgttttgt agatgatatc gtaaaaacag atggtacact tatgattgaa cggttcgtgt   16020
ctttagctat agatgcttac ccacttacta aacatcctaa tcaggagtat gctgatgtct   16080
ttcatttgta cttacaatac ataagaaagc tacatgatga gttaacagga cacatgttag   16140
acatgtattc tgttatgctt actaatgata acacttcaag gtattgggaa cctgagtttt   16200
atgaggctat gtacacaccg catacagtct tacaggctgt tggggcttgt gttctttgca   16260
attcacagac ttcattaaga tgtggtgctt gcatacgtag accattctta tgttgtaaat   16320
gctgttacga ccatgtcata tcaacatcac ataaattagt cttgtctgtt aatccgtatg   16380
tttgcaatgc tccaggttgt gatgtcacag atgtgactca actttactta ggaggtatga   16440
gctattattg taaatcacat aaaccaccca ttagttttcc attgtgtgct aatggacaag   16500
tttttggttt atataaaaat acatgtgttg gtagcgataa tgttactgac tttaatgcaa   16560
ttgcaacatg tgactggaca aatgctggtg attacatttt agctaacacc tgtactgaaa   16620
gactcaagct ttttgcagca gaaacgctca aagctactga ggagacattt aaactgtctt   16680
atggtattgc tactgtacgt gaagtgctgt ctgacagaga attacatctt tcatgggaag   16740
ttggtaaacc tagaccacca cttaaccgaa attatgtctt tactggttat cgtgtaacta   16800
aaaacagtaa agtacaaata ggagagtaca cctttgaaaa aggtgactat ggtgatgctg   16860
ttgtttaccg aggtacaaca acttacaaat taaatgttgg tgattatttt gtgctgacat   16920
cacatacagt aatgccatta agtgcaccta cactagtgcc acaagagcac tatgttagaa   16980
ttactggctt atacccaaca ctcaatatct cagatgagtt ttctagcaat gttgcaaatt   17040
atcaaaaggt tggtatgcaa aagtattcta cactccaggg accacctggt actggtaaga   17100
gtcattttgc tattggccta gctctctact acccttctgc tcgcatagtg tatacagctt   17160
gctctcatgc cgctgttgat gcactatgtg agaaggcatt aaaatatttg cctatagata   17220
aatgtagtag aattatacct gcacgtgctc gtgtagagtg ttttgataaa ttcaaagtga   17280
attcaacatt agaacagtat gtcttttgta ctgtaaatgc attgcctgag acgacagcag   17340
atatagttgt ctttgatgaa atttcaatgg ccacaaatta tgatttgagt gttgtcaatg   17400
ccagattacg tgctaagcac tatgtgtaca ttggcgaccc tgctcaatta cctgcaccac   17460
gcacattgct aactaagggc acactagaac cagaatattt caattcagtg tgtagactta   17520
tgaaaactat aggtccagac atgttcctcg gaacttgtcg gcgttgtcct gctgaaattg   17580
ttgacactgt gagtgctttg gtttatgata ataagcttaa agcacataaa gacaaatcag   17640
ctcaatgctt taaaatgttt tataagggtg ttatcacgca tgatgtttca tctgcaatta   17700
acaggccaca aataggcgtg gtaagagaat tccttacacg taaccctgct tggagaaaag   17760
ctgtctttat ttcaccttat aattcacaga atgctgtagc ctcaaagatt ttgggactac   17820
caactcaaac tgttgattca tcacagggct cagaatatga ctatgtcata ttcactcaaa   17880
ccactgaaac agctcactct tgtaatgtaa acagatttaa tgttgctatt accagagcaa   17940
aagtaggcat actttgcata atgtctgata gagaccttta tgacaagttg caatttacaa   18000
gtcttgaaat tccacgtagg aatgtggcaa ctttacaagc tgaaaatgta acaggactct   18060
ttaaagattg tagtaaggta atcactgggt tacatcctac acaggcacct acacacctca   18120
gtgttgacac taaattcaaa actgaaggtt tatgtgttga catacctggc atacctaagg   18180
acatgaccta tagaagactc atctctatga tgggttttaa aatgaattat caagttaatg   18240
gttaccctaa catgtttatc acccgcgaag aagctataag acatgtacgt gcatggattg   18300
gcttcgatgt cgaggggtgt catgctacta gagaagctgt tggtaccaat ttacctttac   18360
agctaggttt ttctacaggt gttaacctag ttgctgtacc tacaggttat gttgatacac   18420
ctaataatac agatttttcc agagttagtg ctaaaccacc gcctggagat caatttaaac   18480
acctcatacc acttatgtac aaaggacttc cttggaatgt agtgcgtata aagattgtac   18540
aaatgttaag tgacacactt aaaaatctct ctgacagagt cgtatttgtc ttatgggcac   18600
atggctttga gttgacatct atgaagtatt ttgtgaaaat aggacctgag cgcacctgtt   18660
gtctatgtga tagacgtgcc acatgctttt ccactgcttc agacacttat gcctgttggc   18720
atcattctat tggatttgat tacgtctata atccgtttat gattgatgtt caacaatggg   18780
gttttacagg taacctacaa agcaaccatg atctgtattg tcaagtccat ggtaatgcac   18840
atgtagctag ttgtgatgca atcatgacta ggtgtctagc tgtccacgag tgctttgtta   18900
agcgtgttga ctggactatt gaatatccta taattggtga tgaactgaag attaatgcgg   18960
cttgtagaaa ggttcaacac atggttgtta aagctgcatt attagcagac aaattcccag   19020
ttcttcacga cattggtaac cctaaagcta ttaagtgtgt acctcaagct gatgtagaat   19080
ggaagttcta tgatgcacag ccttgtagtg acaaagctta taaaatagaa gaattattct   19140
attcttatgc cacacattct gacaaattca cagatggtgt atgcctattt tggaattgca   19200
atgtcgatag atatcctgct aattccattg tttgtagatt tgacactaga gtgctatcta   19260
accttaactt gcctggttgt gatggtggca gtttgtatgt aaataaacat gcattccaca   19320
caccagcttt tgataaaagt gcttttgtta atttaaaaca attaccattt ttctattact   19380
ctgacagtcc atgtgagtct catggaaaac aagtagtgtc agatatagat tatgtaccac   19440
taaagtctgc tacgtgtata acacgttgca atttaggtgg tgctgtctgt agacatcatg   19500
ctaatgagta cagattgtat ctcgatgctt ataacatgat gatctcagct ggctttagct   19560
tgtgggttta caaacaattt gatacttata acctctggaa cacttttaca agacttcaga   19620
gtttagaaaa tgtggctttt aatgttgtaa ataagggaca ctttgatgga caacagggtg   19680
aagtaccagt ttctatcatt aataacactg tttacacaaa agttgatggt gttgatgtag   19740
aattgtttga aaataaaaca acattacctg ttaatgtagc atttgagctt tgggctaagc   19800
gcaacattaa accagtacca gaggtgaaaa tactcaataa tttgggtgtg gacattgctg   19860
ctaatactgt gatctgggac tacaaaagag atgctccagc acatatatct actattggtg   19920
tttgttctat gactgacata gccaagaaac caactgaaac gatttgtgca ccactcactg   19980
tcttttttga tggtagagtt gatggtcaag tagacttatt tagaaatgcc cgtaatggtg   20040
ttcttattac agaaggtagt gttaaaggtt tacaaccatc tgtaggtccc aaacaagcta   20100
gtcttaatgg agtcacatta attggagaag ccgtaaaaac acagttcaat tattataaga   20160
aagttgatgg tgttgtccaa caattacctg aaacttactt tactcagagt agaaatttac   20220
aagaatttaa acccaggagt caaatggaaa ttgatttctt agaattagct atggatgaat   20280
tcattgaacg gtataaatta gaaggctatg ccttcgaaca tatcgtttat ggagatttta   20340
gtcatagtca gttaggtggt ttacatctac tgattggact agctaaacgt tttaaggaat   20400
caccttttga attagaagat tttattccta tggacagtac agttaaaaac tatttcataa   20460
cagatgcgca aacaggttca tctaagtgtg tgtgttctgt tattgattta ttacttgatg   20520
attttgttga aataataaaa tcccaagatt tatctgtagt ttctaaggtt gtcaaagtga   20580
ctattgacta tacagaaatt tcatttatgc tttggtgtaa agatggccat gtagaaacat   20640
tttacccaaa attacaatct agtcaagcgt ggcaaccggg tgttgctatg cctaatcttt   20700
acaaaatgca aagaatgcta ttagaaaagt gtgaccttca aaattatggt gatagtgcaa   20760
cattacctaa aggcataatg atgaatgtcg caaaatatac tcaactgtgt caatatttaa   20820
acacattaac attagctgta ccctataata tgagagttat acattttggt gctggttctg   20880
ataaaggagt tgcaccaggt acagctgttt taagacagtg gttgcctacg ggtacgctgc   20940
ttgtcgattc agatcttaat gactttgtct ctgatgcaga ttcaactttg attggtgatt   21000
gtgcaactgt acatacagct aataaatggg atctcattat tagtgatatg tacgacccta   21060
agactaaaaa tgttacaaaa gaaaatgact ctaaagaggg ttttttcact tacatttgtg   21120
ggtttataca acaaaagcta gctcttggag gttccgtggc tataaagata acagaacatt   21180
cttggaatgc tgatctttat aagctcatgg gacacttcgc atggtggaca gcctttgtta   21240
ctaatgtgaa tgcgtcatca tctgaagcat ttttaattgg atgtaattat cttggcaaac   21300
cacgcgaaca aatagatggt tatgtcatgc atgcaaatta catattttgg aggaatacaa   21360
atccaattca gttgtcttcc tattctttat ttgacatgag taaatttccc cttaaattaa   21420
ggggtactgc tgttatgtct ttaaaagaag gtcaaatcaa tgatatgatt ttatctcttc   21480
ttagtaaagg tagacttata attagagaaa acaacagagt tgttatttct agtgatgttc   21540
ttgttaacaa ctaaacgaac aatgtttgtt tttcttgttt tattgccact agtctctagt   21600
cagtgtgtta atcttacaac cagaactcaa ttaccccctg catacactaa ttctttcaca   21660
cgtggtgttt attaccctga caaagttttc agatcctcag ttttacattc aactcaggac   21720
ttgttcttac ctttcttttc caatgttact tggttccatg ctatacatgt ctctgggacc   21780
aatggtacta agaggtttga taaccctgtc ctaccattta atgatggtgt ttattttgct   21840
tccactgaga agtctaacat aataagaggc tggatttttg gtactacttt agattcgaag   21900
acccagtccc tacttattgt taataacgct actaatgttg ttattaaagt ctgtgaattt   21960
caattttgta atgatccatt tttgggtgtt tattaccaca aaaacaacaa aagttggatg   22020
gaaagtgagt tcagagttta ttctagtgcg aataattgca cttttgaata tgtctctcag   22080
ccttttctta tggaccttga aggaaaacag ggtaatttca aaaatcttag ggaatttgtg   22140
tttaagaata ttgatggtta ttttaaaata tattctaagc acacgcctat taatttagtg   22200
cgtgatctcc ctcagggttt ttcggcttta gaaccattgg tagatttgcc aataggtatt   22260
aacatcacta ggtttcaaac tttacttgct ttacatagaa gttatttgac tcctggtgat   22320
tcttcttcag gttggacagc tggtgctgca gcttattatg tgggttatct tcaacctagg   22380
acttttctat taaaatataa tgaaaatgga accattacag atgctgtaga ctgtgcactt   22440
gaccctctct cagaaacaaa gtgtacgttg aaatccttca ctgtagaaaa aggaatctat   22500
caaacttcta actttagagt ccaaccaaca gaatctattg ttagatttcc taatattaca   22560
aacttgtgcc cttttggtga agtttttaac gccaccagat ttgcatctgt ttatgcttgg   22620
aacaggaaga gaatcagcaa ctgtgttgct gattattctg tcctatataa ttccgcatca   22680
ttttccactt ttaagtgtta tggagtgtct cctactaaat taaatgatct ctgctttact   22740
aatgtctatg cagattcatt tgtaattaga ggtgatgaag tcagacaaat cgctccaggg   22800
caaactggaa agattgctga ttataattat aaattaccag atgattttac aggctgcgtt   22860
atagcttgga attctaacaa tcttgattct aaggttggtg gtaattataa ttacctgtat   22920
agattgttta ggaagtctaa tctcaaacct tttgagagag atatttcaac tgaaatctat   22980
caggccggta gcacaccttg taatggtgtt gaaggtttta attgttactt tcctttacaa   23040
tcatatggtt tccaacccac taatggtgtt ggttaccaac catacagagt agtagtactt   23100
tcttttgaac ttctacatgc accagcaact gtttgtggac ctaaaaagtc tactaatttg   23160
gttaaaaaca aatgtgtcaa tttcaacttc aatggtttaa caggcacagg tgttcttact   23220
gagtctaaca aaaagtttct gcctttccaa caatttggca gagacattgc tgacactact   23280
gatgctgtcc gtgatccaca gacacttgag attcttgaca ttacaccatg ttcttttggt   23340
ggtgtcagtg ttataacacc aggaacaaat acttctaacc aggttgctgt tctttatcag   23400
gatgttaact gcacagaagt ccctgttgct attcatgcag atcaacttac tcctacttgg   23460
cgtgtttatt ctacaggttc taatgttttt caaacacgtg caggctgttt aataggggct   23520
gaacatgtca acaactcata tgagtgtgac atacccattg gtgcaggtat atgcgctagt   23580
tatcagactc agactaattc tcctcggcgg gcacgtagtg tagctagtca atccatcatt   23640
gcctacacta tgtcacttgg tgcagaaaat tcagttgctt actctaataa ctctattgcc   23700
atacccacaa attttactat tagtgttacc acagaaattc taccagtgtc tatgaccaag   23760
acatcagtag attgtacaat gtacatttgt ggtgattcaa ctgaatgcag caatcttttg   23820
ttgcaatatg gcagtttttg tacacaatta aaccgtgctt taactggaat agctgttgaa   23880
caagacaaaa acacccaaga agtttttgca caagtcaaac aaatttacaa aacaccacca   23940
attaaagatt ttggtggttt taatttttca caaatattac cagatccatc aaaaccaagc   24000
aagaggtcat ttattgaaga tctacttttc aacaaagtga cacttgcaga tgctggcttc   24060
atcaaacaat atggtgattg ccttggtgat attgctgcta gagacctcat ttgtgcacaa   24120
aagtttaacg gccttactgt tttgccacct ttgctcacag atgaaatgat tgctcaatac   24180
acttctgcac tgttagcggg tacaatcact tctggttgga cctttggtgc aggtgctgca   24240
ttacaaatac catttgctat gcaaatggct tataggttta atggtattgg agttacacag   24300
aatgttctct atgagaacca aaaattgatt gccaaccaat ttaatagtgc tattggcaaa   24360
attcaagact cactttcttc cacagcaagt gcacttggaa aacttcaaga tgtggtcaac   24420
caaaatgcac aagctttaaa cacgcttgtt aaacaactta gctccaattt tggtgcaatt   24480
tcaagtgttt taaatgatat cctttcacgt cttgacaaag ttgaggctga agtgcaaatt   24540
gataggttga tcacaggcag acttcaaagt ttgcagacat atgtgactca acaattaatt   24600
agagctgcag aaatcagagc ttctgctaat cttgctgcta ctaaaatgtc agagtgtgta   24660
cttggacaat caaaaagagt tgatttttgt ggaaagggct atcatcttat gtccttccct   24720
cagtcagcac ctcatggtgt agtcttcttg catgtgactt atgtccctgc acaagaaaag   24780
aacttcacaa ctgctcctgc catttgtcat gatggaaaag cacactttcc tcgtgaaggt   24840
gtctttgttt caaatggcac acactggttt gtaacacaaa ggaattttta tgaaccacaa   24900
atcattacta cagacaacac atttgtgtct ggtaactgtg atgttgtaat aggaattgtc   24960
aacaacacag tttatgatcc tttgcaacct gaattagact cattcaagga ggagttagat   25020
aaatatttta agaatcatac atcaccagat gttgatttag gtgacatctc tggcattaat   25080
gcttcagttg taaacattca aaaagaaatt gaccgcctca atgaggttgc caagaattta   25140
aatgaatctc tcatcgatct ccaagaactt ggaaagtatg agcagtatat aaaatggcca   25200
tggtacattt ggctaggttt tatagctggc ttgattgcca tagtaatggt gacaattatg   25260
ctttgctgta tgaccagttg ctgtagttgt ctcaagggct gttgttcttg tggatcctgc   25320
tgcaaatttg atgaagacga ctctgagcca gtgctcaaag gagtcaaatt acattacaca   25380
taaacgaact tatggatttg tttatgagaa tcttcacaat tggaactgta actttgaagc   25440
aaggtgaaat caaggatgct actccttcag attttgttcg cgctactgca acgataccga   25500
tacaagcctc actccctttc ggatggctta ttgttggcgt tgcacttctt gctgtttttc   25560
agagcgcttc caaaatcata accctcaaaa agagatggca actagcactc tccaagggtg   25620
ttcactttgt ttgcaacttg ctgttgttgt ttgtaacagt ttactcacac cttttgctcg   25680
ttgctgctgg ccttgaagcc ccttttctct atctttatgc tttagtctac ttcttgcaga   25740
gtataaactt tgtaagaata ataatgaggc tttggctttg ctggaaatgc cgttccaaaa   25800
acccattact ttatgatgcc aactattttc tttgctggca tactaattgt tacgactatt   25860
gtatacctta caatagtgta acttcttcaa ttgtcattac ttcaggtgat ggcacaacaa   25920
gtcctatttc tgaacatgac taccagattg gtggttatac tgaaaaatgg gaatctggag   25980
taaaagactg tgttgtatta cacagttact tcacttcaga ctattaccag ctgtactcaa   26040
ctcaattgag tacagacact ggtgttgaac atgttacctt cttcatctac aataaaattg   26100
ttgatgagcc tgaagaacat gtccaaattc acacaatcga cggttcatcc ggagttgtta   26160
atccagtaat ggaaccaatt tatgatgaac cgacgacgac tactagcgtg cctttgtaag   26220
cacaagctga tgagtacgaa cttatgtact cattcgtttc ggaagagaca ggtacgttaa   26280
tagttaatag cgtacttctt tttcttgctt tcgtggtatt cttgctagtt acactagcca   26340
tccttactgc gcttcgattg tgtgcgtact gctgcaatat tgttaacgtg agtcttgtaa   26400
aaccttcttt ttacgtttac tctcgtgtta aaaatctgaa ttcttctaga gttcctgatc   26460
ttctggtcta aacgaactaa atattatatt agtttttctg tttggaactt taattttagc   26520
catggcagat tccaacggta ctattaccgt tgaagagctt aaaaagctcc ttgaacaatg   26580
gaacctagta ataggtttcc tattccttac atggatttgt cttctacaat ttgcctatgc   26640
caacaggaat aggtttttgt atataattaa gttaattttc ctctggctgt tatggccagt   26700
aactttagct tgttttgtgc ttgctgctgt ttacagaata aattggatca ccggtggaat   26760
tgctatcgca atggcttgtc ttgtaggctt gatgtggctc agctacttca ttgcttcttt   26820
cagactgttt gcgcgtacgc gttccatgtg gtcattcaat ccagaaacta acattcttct   26880
caacgtgcca ctccatggca ctattctgac cagaccgctt ctagaaagtg aactcgtaat   26940
cggagctgtg atccttcgtg gacatcttcg tattgctgga caccatctag gacgctgtga   27000
catcaaggac ctgcctaaag aaatcactgt tgctacatca cgaacgcttt cttattacaa   27060
attgggagct tcgcagcgtg tagcaggtga ctcaggtttt gctgcataca gtcgctacag   27120
gattggcaac tataaattaa acacagacca ttccagtagc agtgacaata ttgctttgct   27180
tgtacagtaa gtgacaacag atgtttcatc tcgttgactt tcaggttact atagcagaga   27240
tattactaat tattatgagg acttttaaag tttccatttg gaatcttgat tacatcataa   27300
acctcataat taaaaattta tctaagtcac taactgagaa taaatattct caattagatg   27360
aagagcaacc aatggagatt gattaaacga acatgaaaat tattcttttc ttggcactga   27420
taacactcgc tacttgtgag ctttatcact accaagagtg tgttagaggt acaacagtac   27480
ttttaaaaga accttgctct tctggaacat acgagggcaa ttcaccattt catcctctag   27540
ctgataacaa atttgcactg acttgcttta gcactcaatt tgcttttgct tgtcctgacg   27600
gcgtaaaaca cgtctatcag ttacgtgcca gatcagtttc acctaaactg ttcatcagac   27660
aagaggaagt tcaagaactt tactctccaa tttttcttat tgttgcggca atagtgttta   27720
taacactttg cttcacactc aaaagaaaga cagaatgatt gaactttcat taattgactt   27780
ctatttgtgc tttttagcct ttctgctatt ccttgtttta attatgctta ttatcttttg   27840
gttctcactt gaactgcaag atcataatga aacttgtcac gcctaaacga acatgaaatt   27900
tcttgttttc ttaggaatca tcacaactgt agctgcattt caccaagaat gtagtttaca   27960
gtcatgtact caacatcaac catatgtagt tgatgacccg tgtcctattc acttctattc   28020
taaatggtat attagagtag gagctagaaa atcagcacct ttaattgaat tgtgcgtgga   28080
tgaggctggt tctaaatcac ccattcagta catcgatatc ggtaattata cagtttcctg   28140
tttacctttt acaattaatt gccaggaacc taaattgggt agtcttgtag tgcgttgttc   28200
gttctatgaa gactttttag agtatcatga cgttcgtgtt gttttagatt tcatctaaac   28260
gaacaaacta aaatgtctga taatggaccc caaaatcagc gaaatgcacc ccgcattacg   28320
tttggtggac cctcagattc aactggcagt aaccagaatg gagaacgcag tggggcgcga   28380
tcaaaacaac gtcggcccca aggtttaccc aataatactg cgtcttggtt caccgctctc   28440
actcaacatg gcaaggaaga ccttaaattc cctcgaggac aaggcgttcc aattaacacc   28500
aatagcagtc cagatgacca aattggctac taccgaagag ctaccagacg aattcgtggt   28560
ggtgacggta aaatgaaaga tctcagtcca agatggtatt tctactacct aggaactggg   28620
ccagaagctg gacttcccta tggtgctaac aaagacggca tcatatgggt tgcaactgag   28680
ggagccttga atacaccaaa agatcacatt ggcacccgca atcctgctaa caatgctgca   28740
atcgtgctac aacttcctca aggaacaaca ttgccaaaag gcttctacgc agaagggagc   28800
agaggcggca gtcaagcctc ttctcgttcc tcatcacgta gtcgcaacag ttcaagaaat   28860
tcaactccag gcagcagtag gggaacttct cctgctagaa tggctggcaa tggcggtgat   28920
gctgctcttg ctttgctgct gcttgacaga ttgaaccagc ttgagagcaa aatgtctggt   28980
aaaggccaac aacaacaagg ccaaactgtc actaagaaat ctgctgctga ggcttctaag   29040
aagcctcggc aaaaacgtac tgccactaaa gcatacaatg taacacaagc tttcggcaga   29100
cgtggtccag aacaaaccca aggaaatttt ggggaccagg aactaatcag acaaggaact   29160
gattacaaac attggccgca aattgcacaa tttgccccca gcgcttcagc gttcttcgga   29220
atgtcgcgca ttggcatgga agtcacacct tcgggaacgt ggttgaccta cacaggtgcc   29280
atcaaattgg atgacaaaga tccaaatttc aaagatcaag tcattttgct gaataagcat   29340
attgacgcat acaaaacatt cccaccaaca gagcctaaaa aggacaaaaa gaagaaggct   29400
gatgaaactc aagccttacc gcagagacag aagaaacagc aaactgtgac tcttcttcct   29460
gctgcagatt tggatgattt ctccaaacaa ttgcaacaat ccatgagcag tgctgactca   29520
actcaggcct aaactcatgc agaccacaca aggcagatgg gctatataaa cgttttcgct   29580
tttccgttta cgatatatag tctactcttg tgcagaatga attctcgtaa ctacatagca   29640
caagtagatg tagttaactt taatctcaca tagcaatctt taatcagtgt gtaacattag   29700
ggaggacttg aaagagccac cacattttca ccgaggccac gcggagtacg atcgagtgta   29760
cagtgaacaa tgctagggag agctgcctat atggaagagc cctaatgtgt aaaattaatt   29820
ttagtagtgc tatccccatg tgattttaat agcttcttag gagaatgaca aaaaaaaaaa   29880
aaaaaaaaaa aaaaaaaaaa aa                                            29902



<210>  2
<211>  7096
<212>  PRT
<213>  betacoronavirus SARS coronavirus 2

<400>  2

Met Glu Ser Leu Val Pro Gly Phe Asn Glu Lys Thr His Val Gln Leu 
1               5                   10                  15      


Ser Leu Pro Val Leu Gln Val Arg Asp Val Leu Val Arg Gly Phe Gly 
            20                  25                  30          


Asp Ser Val Glu Glu Val Leu Ser Glu Ala Arg Gln His Leu Lys Asp 
        35                  40                  45              


Gly Thr Cys Gly Leu Val Glu Val Glu Lys Gly Val Leu Pro Gln Leu 
    50                  55                  60                  


Glu Gln Pro Tyr Val Phe Ile Lys Arg Ser Asp Ala Arg Thr Ala Pro 
65                  70                  75                  80  


His Gly His Val Met Val Glu Leu Val Ala Glu Leu Glu Gly Ile Gln 
                85                  90                  95      


Tyr Gly Arg Ser Gly Glu Thr Leu Gly Val Leu Val Pro His Val Gly 
            100                 105                 110         


Glu Ile Pro Val Ala Tyr Arg Lys Val Leu Leu Arg Lys Asn Gly Asn 
        115                 120                 125             


Lys Gly Ala Gly Gly His Ser Tyr Gly Ala Asp Leu Lys Ser Phe Asp 
    130                 135                 140                 


Leu Gly Asp Glu Leu Gly Thr Asp Pro Tyr Glu Asp Phe Gln Glu Asn 
145                 150                 155                 160 


Trp Asn Thr Lys His Ser Ser Gly Val Thr Arg Glu Leu Met Arg Glu 
                165                 170                 175     


Leu Asn Gly Gly Ala Tyr Thr Arg Tyr Val Asp Asn Asn Phe Cys Gly 
            180                 185                 190         


Pro Asp Gly Tyr Pro Leu Glu Cys Ile Lys Asp Leu Leu Ala Arg Ala 
        195                 200                 205             


Gly Lys Ala Ser Cys Thr Leu Ser Glu Gln Leu Asp Phe Ile Asp Thr 
    210                 215                 220                 


Lys Arg Gly Val Tyr Cys Cys Arg Glu His Glu His Glu Ile Ala Trp 
225                 230                 235                 240 


Tyr Thr Glu Arg Ser Glu Lys Ser Tyr Glu Leu Gln Thr Pro Phe Glu 
                245                 250                 255     


Ile Lys Leu Ala Lys Lys Phe Asp Thr Phe Asn Gly Glu Cys Pro Asn 
            260                 265                 270         


Phe Val Phe Pro Leu Asn Ser Ile Ile Lys Thr Ile Gln Pro Arg Val 
        275                 280                 285             


Glu Lys Lys Lys Leu Asp Gly Phe Met Gly Arg Ile Arg Ser Val Tyr 
    290                 295                 300                 


Pro Val Ala Ser Pro Asn Glu Cys Asn Gln Met Cys Leu Ser Thr Leu 
305                 310                 315                 320 


Met Lys Cys Asp His Cys Gly Glu Thr Ser Trp Gln Thr Gly Asp Phe 
                325                 330                 335     


Val Lys Ala Thr Cys Glu Phe Cys Gly Thr Glu Asn Leu Thr Lys Glu 
            340                 345                 350         


Gly Ala Thr Thr Cys Gly Tyr Leu Pro Gln Asn Ala Val Val Lys Ile 
        355                 360                 365             


Tyr Cys Pro Ala Cys His Asn Ser Glu Val Gly Pro Glu His Ser Leu 
    370                 375                 380                 


Ala Glu Tyr His Asn Glu Ser Gly Leu Lys Thr Ile Leu Arg Lys Gly 
385                 390                 395                 400 


Gly Arg Thr Ile Ala Phe Gly Gly Cys Val Phe Ser Tyr Val Gly Cys 
                405                 410                 415     


His Asn Lys Cys Ala Tyr Trp Val Pro Arg Ala Ser Ala Asn Ile Gly 
            420                 425                 430         


Cys Asn His Thr Gly Val Val Gly Glu Gly Ser Glu Gly Leu Asn Asp 
        435                 440                 445             


Asn Leu Leu Glu Ile Leu Gln Lys Glu Lys Val Asn Ile Asn Ile Val 
    450                 455                 460                 


Gly Asp Phe Lys Leu Asn Glu Glu Ile Ala Ile Ile Leu Ala Ser Phe 
465                 470                 475                 480 


Ser Ala Ser Thr Ser Ala Phe Val Glu Thr Val Lys Gly Leu Asp Tyr 
                485                 490                 495     


Lys Ala Phe Lys Gln Ile Val Glu Ser Cys Gly Asn Phe Lys Val Thr 
            500                 505                 510         


Lys Gly Lys Ala Lys Lys Gly Ala Trp Asn Ile Gly Glu Gln Lys Ser 
        515                 520                 525             


Ile Leu Ser Pro Leu Tyr Ala Phe Ala Ser Glu Ala Ala Arg Val Val 
    530                 535                 540                 


Arg Ser Ile Phe Ser Arg Thr Leu Glu Thr Ala Gln Asn Ser Val Arg 
545                 550                 555                 560 


Val Leu Gln Lys Ala Ala Ile Thr Ile Leu Asp Gly Ile Ser Gln Tyr 
                565                 570                 575     


Ser Leu Arg Leu Ile Asp Ala Met Met Phe Thr Ser Asp Leu Ala Thr 
            580                 585                 590         


Asn Asn Leu Val Val Met Ala Tyr Ile Thr Gly Gly Val Val Gln Leu 
        595                 600                 605             


Thr Ser Gln Trp Leu Thr Asn Ile Phe Gly Thr Val Tyr Glu Lys Leu 
    610                 615                 620                 


Lys Pro Val Leu Asp Trp Leu Glu Glu Lys Phe Lys Glu Gly Val Glu 
625                 630                 635                 640 


Phe Leu Arg Asp Gly Trp Glu Ile Val Lys Phe Ile Ser Thr Cys Ala 
                645                 650                 655     


Cys Glu Ile Val Gly Gly Gln Ile Val Thr Cys Ala Lys Glu Ile Lys 
            660                 665                 670         


Glu Ser Val Gln Thr Phe Phe Lys Leu Val Asn Lys Phe Leu Ala Leu 
        675                 680                 685             


Cys Ala Asp Ser Ile Ile Ile Gly Gly Ala Lys Leu Lys Ala Leu Asn 
    690                 695                 700                 


Leu Gly Glu Thr Phe Val Thr His Ser Lys Gly Leu Tyr Arg Lys Cys 
705                 710                 715                 720 


Val Lys Ser Arg Glu Glu Thr Gly Leu Leu Met Pro Leu Lys Ala Pro 
                725                 730                 735     


Lys Glu Ile Ile Phe Leu Glu Gly Glu Thr Leu Pro Thr Glu Val Leu 
            740                 745                 750         


Thr Glu Glu Val Val Leu Lys Thr Gly Asp Leu Gln Pro Leu Glu Gln 
        755                 760                 765             


Pro Thr Ser Glu Ala Val Glu Ala Pro Leu Val Gly Thr Pro Val Cys 
    770                 775                 780                 


Ile Asn Gly Leu Met Leu Leu Glu Ile Lys Asp Thr Glu Lys Tyr Cys 
785                 790                 795                 800 


Ala Leu Ala Pro Asn Met Met Val Thr Asn Asn Thr Phe Thr Leu Lys 
                805                 810                 815     


Gly Gly Ala Pro Thr Lys Val Thr Phe Gly Asp Asp Thr Val Ile Glu 
            820                 825                 830         


Val Gln Gly Tyr Lys Ser Val Asn Ile Thr Phe Glu Leu Asp Glu Arg 
        835                 840                 845             


Ile Asp Lys Val Leu Asn Glu Lys Cys Ser Ala Tyr Thr Val Glu Leu 
    850                 855                 860                 


Gly Thr Glu Val Asn Glu Phe Ala Cys Val Val Ala Asp Ala Val Ile 
865                 870                 875                 880 


Lys Thr Leu Gln Pro Val Ser Glu Leu Leu Thr Pro Leu Gly Ile Asp 
                885                 890                 895     


Leu Asp Glu Trp Ser Met Ala Thr Tyr Tyr Leu Phe Asp Glu Ser Gly 
            900                 905                 910         


Glu Phe Lys Leu Ala Ser His Met Tyr Cys Ser Phe Tyr Pro Pro Asp 
        915                 920                 925             


Glu Asp Glu Glu Glu Gly Asp Cys Glu Glu Glu Glu Phe Glu Pro Ser 
    930                 935                 940                 


Thr Gln Tyr Glu Tyr Gly Thr Glu Asp Asp Tyr Gln Gly Lys Pro Leu 
945                 950                 955                 960 


Glu Phe Gly Ala Thr Ser Ala Ala Leu Gln Pro Glu Glu Glu Gln Glu 
                965                 970                 975     


Glu Asp Trp Leu Asp Asp Asp Ser Gln Gln Thr Val Gly Gln Gln Asp 
            980                 985                 990         


Gly Ser Glu Asp Asn Gln Thr Thr  Thr Ile Gln Thr Ile  Val Glu Val 
        995                 1000                 1005             


Gln Pro  Gln Leu Glu Met Glu  Leu Thr Pro Val Val  Gln Thr Ile 
    1010                 1015                 1020             


Glu Val  Asn Ser Phe Ser Gly  Tyr Leu Lys Leu Thr  Asp Asn Val 
    1025                 1030                 1035             


Tyr Ile  Lys Asn Ala Asp Ile  Val Glu Glu Ala Lys  Lys Val Lys 
    1040                 1045                 1050             


Pro Thr  Val Val Val Asn Ala  Ala Asn Val Tyr Leu  Lys His Gly 
    1055                 1060                 1065             


Gly Gly  Val Ala Gly Ala Leu  Asn Lys Ala Thr Asn  Asn Ala Met 
    1070                 1075                 1080             


Gln Val  Glu Ser Asp Asp Tyr  Ile Ala Thr Asn Gly  Pro Leu Lys 
    1085                 1090                 1095             


Val Gly  Gly Ser Cys Val Leu  Ser Gly His Asn Leu  Ala Lys His 
    1100                 1105                 1110             


Cys Leu  His Val Val Gly Pro  Asn Val Asn Lys Gly  Glu Asp Ile 
    1115                 1120                 1125             


Gln Leu  Leu Lys Ser Ala Tyr  Glu Asn Phe Asn Gln  His Glu Val 
    1130                 1135                 1140             


Leu Leu  Ala Pro Leu Leu Ser  Ala Gly Ile Phe Gly  Ala Asp Pro 
    1145                 1150                 1155             


Ile His  Ser Leu Arg Val Cys  Val Asp Thr Val Arg  Thr Asn Val 
    1160                 1165                 1170             


Tyr Leu  Ala Val Phe Asp Lys  Asn Leu Tyr Asp Lys  Leu Val Ser 
    1175                 1180                 1185             


Ser Phe  Leu Glu Met Lys Ser  Glu Lys Gln Val Glu  Gln Lys Ile 
    1190                 1195                 1200             


Ala Glu  Ile Pro Lys Glu Glu  Val Lys Pro Phe Ile  Thr Glu Ser 
    1205                 1210                 1215             


Lys Pro  Ser Val Glu Gln Arg  Lys Gln Asp Asp Lys  Lys Ile Lys 
    1220                 1225                 1230             


Ala Cys  Val Glu Glu Val Thr  Thr Thr Leu Glu Glu  Thr Lys Phe 
    1235                 1240                 1245             


Leu Thr  Glu Asn Leu Leu Leu  Tyr Ile Asp Ile Asn  Gly Asn Leu 
    1250                 1255                 1260             


His Pro  Asp Ser Ala Thr Leu  Val Ser Asp Ile Asp  Ile Thr Phe 
    1265                 1270                 1275             


Leu Lys  Lys Asp Ala Pro Tyr  Ile Val Gly Asp Val  Val Gln Glu 
    1280                 1285                 1290             


Gly Val  Leu Thr Ala Val Val  Ile Pro Thr Lys Lys  Ala Gly Gly 
    1295                 1300                 1305             


Thr Thr  Glu Met Leu Ala Lys  Ala Leu Arg Lys Val  Pro Thr Asp 
    1310                 1315                 1320             


Asn Tyr  Ile Thr Thr Tyr Pro  Gly Gln Gly Leu Asn  Gly Tyr Thr 
    1325                 1330                 1335             


Val Glu  Glu Ala Lys Thr Val  Leu Lys Lys Cys Lys  Ser Ala Phe 
    1340                 1345                 1350             


Tyr Ile  Leu Pro Ser Ile Ile  Ser Asn Glu Lys Gln  Glu Ile Leu 
    1355                 1360                 1365             


Gly Thr  Val Ser Trp Asn Leu  Arg Glu Met Leu Ala  His Ala Glu 
    1370                 1375                 1380             


Glu Thr  Arg Lys Leu Met Pro  Val Cys Val Glu Thr  Lys Ala Ile 
    1385                 1390                 1395             


Val Ser  Thr Ile Gln Arg Lys  Tyr Lys Gly Ile Lys  Ile Gln Glu 
    1400                 1405                 1410             


Gly Val  Val Asp Tyr Gly Ala  Arg Phe Tyr Phe Tyr  Thr Ser Lys 
    1415                 1420                 1425             


Thr Thr  Val Ala Ser Leu Ile  Asn Thr Leu Asn Asp  Leu Asn Glu 
    1430                 1435                 1440             


Thr Leu  Val Thr Met Pro Leu  Gly Tyr Val Thr His  Gly Leu Asn 
    1445                 1450                 1455             


Leu Glu  Glu Ala Ala Arg Tyr  Met Arg Ser Leu Lys  Val Pro Ala 
    1460                 1465                 1470             


Thr Val  Ser Val Ser Ser Pro  Asp Ala Val Thr Ala  Tyr Asn Gly 
    1475                 1480                 1485             


Tyr Leu  Thr Ser Ser Ser Lys  Thr Pro Glu Glu His  Phe Ile Glu 
    1490                 1495                 1500             


Thr Ile  Ser Leu Ala Gly Ser  Tyr Lys Asp Trp Ser  Tyr Ser Gly 
    1505                 1510                 1515             


Gln Ser  Thr Gln Leu Gly Ile  Glu Phe Leu Lys Arg  Gly Asp Lys 
    1520                 1525                 1530             


Ser Val  Tyr Tyr Thr Ser Asn  Pro Thr Thr Phe His  Leu Asp Gly 
    1535                 1540                 1545             


Glu Val  Ile Thr Phe Asp Asn  Leu Lys Thr Leu Leu  Ser Leu Arg 
    1550                 1555                 1560             


Glu Val  Arg Thr Ile Lys Val  Phe Thr Thr Val Asp  Asn Ile Asn 
    1565                 1570                 1575             


Leu His  Thr Gln Val Val Asp  Met Ser Met Thr Tyr  Gly Gln Gln 
    1580                 1585                 1590             


Phe Gly  Pro Thr Tyr Leu Asp  Gly Ala Asp Val Thr  Lys Ile Lys 
    1595                 1600                 1605             


Pro His  Asn Ser His Glu Gly  Lys Thr Phe Tyr Val  Leu Pro Asn 
    1610                 1615                 1620             


Asp Asp  Thr Leu Arg Val Glu  Ala Phe Glu Tyr Tyr  His Thr Thr 
    1625                 1630                 1635             


Asp Pro  Ser Phe Leu Gly Arg  Tyr Met Ser Ala Leu  Asn His Thr 
    1640                 1645                 1650             


Lys Lys  Trp Lys Tyr Pro Gln  Val Asn Gly Leu Thr  Ser Ile Lys 
    1655                 1660                 1665             


Trp Ala  Asp Asn Asn Cys Tyr  Leu Ala Thr Ala Leu  Leu Thr Leu 
    1670                 1675                 1680             


Gln Gln  Ile Glu Leu Lys Phe  Asn Pro Pro Ala Leu  Gln Asp Ala 
    1685                 1690                 1695             


Tyr Tyr  Arg Ala Arg Ala Gly  Glu Ala Ala Asn Phe  Cys Ala Leu 
    1700                 1705                 1710             


Ile Leu  Ala Tyr Cys Asn Lys  Thr Val Gly Glu Leu  Gly Asp Val 
    1715                 1720                 1725             


Arg Glu  Thr Met Ser Tyr Leu  Phe Gln His Ala Asn  Leu Asp Ser 
    1730                 1735                 1740             


Cys Lys  Arg Val Leu Asn Val  Val Cys Lys Thr Cys  Gly Gln Gln 
    1745                 1750                 1755             


Gln Thr  Thr Leu Lys Gly Val  Glu Ala Val Met Tyr  Met Gly Thr 
    1760                 1765                 1770             


Leu Ser  Tyr Glu Gln Phe Lys  Lys Gly Val Gln Ile  Pro Cys Thr 
    1775                 1780                 1785             


Cys Gly  Lys Gln Ala Thr Lys  Tyr Leu Val Gln Gln  Glu Ser Pro 
    1790                 1795                 1800             


Phe Val  Met Met Ser Ala Pro  Pro Ala Gln Tyr Glu  Leu Lys His 
    1805                 1810                 1815             


Gly Thr  Phe Thr Cys Ala Ser  Glu Tyr Thr Gly Asn  Tyr Gln Cys 
    1820                 1825                 1830             


Gly His  Tyr Lys His Ile Thr  Ser Lys Glu Thr Leu  Tyr Cys Ile 
    1835                 1840                 1845             


Asp Gly  Ala Leu Leu Thr Lys  Ser Ser Glu Tyr Lys  Gly Pro Ile 
    1850                 1855                 1860             


Thr Asp  Val Phe Tyr Lys Glu  Asn Ser Tyr Thr Thr  Thr Ile Lys 
    1865                 1870                 1875             


Pro Val  Thr Tyr Lys Leu Asp  Gly Val Val Cys Thr  Glu Ile Asp 
    1880                 1885                 1890             


Pro Lys  Leu Asp Asn Tyr Tyr  Lys Lys Asp Asn Ser  Tyr Phe Thr 
    1895                 1900                 1905             


Glu Gln  Pro Ile Asp Leu Val  Pro Asn Gln Pro Tyr  Pro Asn Ala 
    1910                 1915                 1920             


Ser Phe  Asp Asn Phe Lys Phe  Val Cys Asp Asn Ile  Lys Phe Ala 
    1925                 1930                 1935             


Asp Asp  Leu Asn Gln Leu Thr  Gly Tyr Lys Lys Pro  Ala Ser Arg 
    1940                 1945                 1950             


Glu Leu  Lys Val Thr Phe Phe  Pro Asp Leu Asn Gly  Asp Val Val 
    1955                 1960                 1965             


Ala Ile  Asp Tyr Lys His Tyr  Thr Pro Ser Phe Lys  Lys Gly Ala 
    1970                 1975                 1980             


Lys Leu  Leu His Lys Pro Ile  Val Trp His Val Asn  Asn Ala Thr 
    1985                 1990                 1995             


Asn Lys  Ala Thr Tyr Lys Pro  Asn Thr Trp Cys Ile  Arg Cys Leu 
    2000                 2005                 2010             


Trp Ser  Thr Lys Pro Val Glu  Thr Ser Asn Ser Phe  Asp Val Leu 
    2015                 2020                 2025             


Lys Ser  Glu Asp Ala Gln Gly  Met Asp Asn Leu Ala  Cys Glu Asp 
    2030                 2035                 2040             


Leu Lys  Pro Val Ser Glu Glu  Val Val Glu Asn Pro  Thr Ile Gln 
    2045                 2050                 2055             


Lys Asp  Val Leu Glu Cys Asn  Val Lys Thr Thr Glu  Val Val Gly 
    2060                 2065                 2070             


Asp Ile  Ile Leu Lys Pro Ala  Asn Asn Ser Leu Lys  Ile Thr Glu 
    2075                 2080                 2085             


Glu Val  Gly His Thr Asp Leu  Met Ala Ala Tyr Val  Asp Asn Ser 
    2090                 2095                 2100             


Ser Leu  Thr Ile Lys Lys Pro  Asn Glu Leu Ser Arg  Val Leu Gly 
    2105                 2110                 2115             


Leu Lys  Thr Leu Ala Thr His  Gly Leu Ala Ala Val  Asn Ser Val 
    2120                 2125                 2130             


Pro Trp  Asp Thr Ile Ala Asn  Tyr Ala Lys Pro Phe  Leu Asn Lys 
    2135                 2140                 2145             


Val Val  Ser Thr Thr Thr Asn  Ile Val Thr Arg Cys  Leu Asn Arg 
    2150                 2155                 2160             


Val Cys  Thr Asn Tyr Met Pro  Tyr Phe Phe Thr Leu  Leu Leu Gln 
    2165                 2170                 2175             


Leu Cys  Thr Phe Thr Arg Ser  Thr Asn Ser Arg Ile  Lys Ala Ser 
    2180                 2185                 2190             


Met Pro  Thr Thr Ile Ala Lys  Asn Thr Val Lys Ser  Val Gly Lys 
    2195                 2200                 2205             


Phe Cys  Leu Glu Ala Ser Phe  Asn Tyr Leu Lys Ser  Pro Asn Phe 
    2210                 2215                 2220             


Ser Lys  Leu Ile Asn Ile Ile  Ile Trp Phe Leu Leu  Leu Ser Val 
    2225                 2230                 2235             


Cys Leu  Gly Ser Leu Ile Tyr  Ser Thr Ala Ala Leu  Gly Val Leu 
    2240                 2245                 2250             


Met Ser  Asn Leu Gly Met Pro  Ser Tyr Cys Thr Gly  Tyr Arg Glu 
    2255                 2260                 2265             


Gly Tyr  Leu Asn Ser Thr Asn  Val Thr Ile Ala Thr  Tyr Cys Thr 
    2270                 2275                 2280             


Gly Ser  Ile Pro Cys Ser Val  Cys Leu Ser Gly Leu  Asp Ser Leu 
    2285                 2290                 2295             


Asp Thr  Tyr Pro Ser Leu Glu  Thr Ile Gln Ile Thr  Ile Ser Ser 
    2300                 2305                 2310             


Phe Lys  Trp Asp Leu Thr Ala  Phe Gly Leu Val Ala  Glu Trp Phe 
    2315                 2320                 2325             


Leu Ala  Tyr Ile Leu Phe Thr  Arg Phe Phe Tyr Val  Leu Gly Leu 
    2330                 2335                 2340             


Ala Ala  Ile Met Gln Leu Phe  Phe Ser Tyr Phe Ala  Val His Phe 
    2345                 2350                 2355             


Ile Ser  Asn Ser Trp Leu Met  Trp Leu Ile Ile Asn  Leu Val Gln 
    2360                 2365                 2370             


Met Ala  Pro Ile Ser Ala Met  Val Arg Met Tyr Ile  Phe Phe Ala 
    2375                 2380                 2385             


Ser Phe  Tyr Tyr Val Trp Lys  Ser Tyr Val His Val  Val Asp Gly 
    2390                 2395                 2400             


Cys Asn  Ser Ser Thr Cys Met  Met Cys Tyr Lys Arg  Asn Arg Ala 
    2405                 2410                 2415             


Thr Arg  Val Glu Cys Thr Thr  Ile Val Asn Gly Val  Arg Arg Ser 
    2420                 2425                 2430             


Phe Tyr  Val Tyr Ala Asn Gly  Gly Lys Gly Phe Cys  Lys Leu His 
    2435                 2440                 2445             


Asn Trp  Asn Cys Val Asn Cys  Asp Thr Phe Cys Ala  Gly Ser Thr 
    2450                 2455                 2460             


Phe Ile  Ser Asp Glu Val Ala  Arg Asp Leu Ser Leu  Gln Phe Lys 
    2465                 2470                 2475             


Arg Pro  Ile Asn Pro Thr Asp  Gln Ser Ser Tyr Ile  Val Asp Ser 
    2480                 2485                 2490             


Val Thr  Val Lys Asn Gly Ser  Ile His Leu Tyr Phe  Asp Lys Ala 
    2495                 2500                 2505             


Gly Gln  Lys Thr Tyr Glu Arg  His Ser Leu Ser His  Phe Val Asn 
    2510                 2515                 2520             


Leu Asp  Asn Leu Arg Ala Asn  Asn Thr Lys Gly Ser  Leu Pro Ile 
    2525                 2530                 2535             


Asn Val  Ile Val Phe Asp Gly  Lys Ser Lys Cys Glu  Glu Ser Ser 
    2540                 2545                 2550             


Ala Lys  Ser Ala Ser Val Tyr  Tyr Ser Gln Leu Met  Cys Gln Pro 
    2555                 2560                 2565             


Ile Leu  Leu Leu Asp Gln Ala  Leu Val Ser Asp Val  Gly Asp Ser 
    2570                 2575                 2580             


Ala Glu  Val Ala Val Lys Met  Phe Asp Ala Tyr Val  Asn Thr Phe 
    2585                 2590                 2595             


Ser Ser  Thr Phe Asn Val Pro  Met Glu Lys Leu Lys  Thr Leu Val 
    2600                 2605                 2610             


Ala Thr  Ala Glu Ala Glu Leu  Ala Lys Asn Val Ser  Leu Asp Asn 
    2615                 2620                 2625             


Val Leu  Ser Thr Phe Ile Ser  Ala Ala Arg Gln Gly  Phe Val Asp 
    2630                 2635                 2640             


Ser Asp  Val Glu Thr Lys Asp  Val Val Glu Cys Leu  Lys Leu Ser 
    2645                 2650                 2655             


His Gln  Ser Asp Ile Glu Val  Thr Gly Asp Ser Cys  Asn Asn Tyr 
    2660                 2665                 2670             


Met Leu  Thr Tyr Asn Lys Val  Glu Asn Met Thr Pro  Arg Asp Leu 
    2675                 2680                 2685             


Gly Ala  Cys Ile Asp Cys Ser  Ala Arg His Ile Asn  Ala Gln Val 
    2690                 2695                 2700             


Ala Lys  Ser His Asn Ile Ala  Leu Ile Trp Asn Val  Lys Asp Phe 
    2705                 2710                 2715             


Met Ser  Leu Ser Glu Gln Leu  Arg Lys Gln Ile Arg  Ser Ala Ala 
    2720                 2725                 2730             


Lys Lys  Asn Asn Leu Pro Phe  Lys Leu Thr Cys Ala  Thr Thr Arg 
    2735                 2740                 2745             


Gln Val  Val Asn Val Val Thr  Thr Lys Ile Ala Leu  Lys Gly Gly 
    2750                 2755                 2760             


Lys Ile  Val Asn Asn Trp Leu  Lys Gln Leu Ile Lys  Val Thr Leu 
    2765                 2770                 2775             


Val Phe  Leu Phe Val Ala Ala  Ile Phe Tyr Leu Ile  Thr Pro Val 
    2780                 2785                 2790             


His Val  Met Ser Lys His Thr  Asp Phe Ser Ser Glu  Ile Ile Gly 
    2795                 2800                 2805             


Tyr Lys  Ala Ile Asp Gly Gly  Val Thr Arg Asp Ile  Ala Ser Thr 
    2810                 2815                 2820             


Asp Thr  Cys Phe Ala Asn Lys  His Ala Asp Phe Asp  Thr Trp Phe 
    2825                 2830                 2835             


Ser Gln  Arg Gly Gly Ser Tyr  Thr Asn Asp Lys Ala  Cys Pro Leu 
    2840                 2845                 2850             


Ile Ala  Ala Val Ile Thr Arg  Glu Val Gly Phe Val  Val Pro Gly 
    2855                 2860                 2865             


Leu Pro  Gly Thr Ile Leu Arg  Thr Thr Asn Gly Asp  Phe Leu His 
    2870                 2875                 2880             


Phe Leu  Pro Arg Val Phe Ser  Ala Val Gly Asn Ile  Cys Tyr Thr 
    2885                 2890                 2895             


Pro Ser  Lys Leu Ile Glu Tyr  Thr Asp Phe Ala Thr  Ser Ala Cys 
    2900                 2905                 2910             


Val Leu  Ala Ala Glu Cys Thr  Ile Phe Lys Asp Ala  Ser Gly Lys 
    2915                 2920                 2925             


Pro Val  Pro Tyr Cys Tyr Asp  Thr Asn Val Leu Glu  Gly Ser Val 
    2930                 2935                 2940             


Ala Tyr  Glu Ser Leu Arg Pro  Asp Thr Arg Tyr Val  Leu Met Asp 
    2945                 2950                 2955             


Gly Ser  Ile Ile Gln Phe Pro  Asn Thr Tyr Leu Glu  Gly Ser Val 
    2960                 2965                 2970             


Arg Val  Val Thr Thr Phe Asp  Ser Glu Tyr Cys Arg  His Gly Thr 
    2975                 2980                 2985             


Cys Glu  Arg Ser Glu Ala Gly  Val Cys Val Ser Thr  Ser Gly Arg 
    2990                 2995                 3000             


Trp Val  Leu Asn Asn Asp Tyr  Tyr Arg Ser Leu Pro  Gly Val Phe 
    3005                 3010                 3015             


Cys Gly  Val Asp Ala Val Asn  Leu Leu Thr Asn Met  Phe Thr Pro 
    3020                 3025                 3030             


Leu Ile  Gln Pro Ile Gly Ala  Leu Asp Ile Ser Ala  Ser Ile Val 
    3035                 3040                 3045             


Ala Gly  Gly Ile Val Ala Ile  Val Val Thr Cys Leu  Ala Tyr Tyr 
    3050                 3055                 3060             


Phe Met  Arg Phe Arg Arg Ala  Phe Gly Glu Tyr Ser  His Val Val 
    3065                 3070                 3075             


Ala Phe  Asn Thr Leu Leu Phe  Leu Met Ser Phe Thr  Val Leu Cys 
    3080                 3085                 3090             


Leu Thr  Pro Val Tyr Ser Phe  Leu Pro Gly Val Tyr  Ser Val Ile 
    3095                 3100                 3105             


Tyr Leu  Tyr Leu Thr Phe Tyr  Leu Thr Asn Asp Val  Ser Phe Leu 
    3110                 3115                 3120             


Ala His  Ile Gln Trp Met Val  Met Phe Thr Pro Leu  Val Pro Phe 
    3125                 3130                 3135             


Trp Ile  Thr Ile Ala Tyr Ile  Ile Cys Ile Ser Thr  Lys His Phe 
    3140                 3145                 3150             


Tyr Trp  Phe Phe Ser Asn Tyr  Leu Lys Arg Arg Val  Val Phe Asn 
    3155                 3160                 3165             


Gly Val  Ser Phe Ser Thr Phe  Glu Glu Ala Ala Leu  Cys Thr Phe 
    3170                 3175                 3180             


Leu Leu  Asn Lys Glu Met Tyr  Leu Lys Leu Arg Ser  Asp Val Leu 
    3185                 3190                 3195             


Leu Pro  Leu Thr Gln Tyr Asn  Arg Tyr Leu Ala Leu  Tyr Asn Lys 
    3200                 3205                 3210             


Tyr Lys  Tyr Phe Ser Gly Ala  Met Asp Thr Thr Ser  Tyr Arg Glu 
    3215                 3220                 3225             


Ala Ala  Cys Cys His Leu Ala  Lys Ala Leu Asn Asp  Phe Ser Asn 
    3230                 3235                 3240             


Ser Gly  Ser Asp Val Leu Tyr  Gln Pro Pro Gln Thr  Ser Ile Thr 
    3245                 3250                 3255             


Ser Ala  Val Leu Gln Ser Gly  Phe Arg Lys Met Ala  Phe Pro Ser 
    3260                 3265                 3270             


Gly Lys  Val Glu Gly Cys Met  Val Gln Val Thr Cys  Gly Thr Thr 
    3275                 3280                 3285             


Thr Leu  Asn Gly Leu Trp Leu  Asp Asp Val Val Tyr  Cys Pro Arg 
    3290                 3295                 3300             


His Val  Ile Cys Thr Ser Glu  Asp Met Leu Asn Pro  Asn Tyr Glu 
    3305                 3310                 3315             


Asp Leu  Leu Ile Arg Lys Ser  Asn His Asn Phe Leu  Val Gln Ala 
    3320                 3325                 3330             


Gly Asn  Val Gln Leu Arg Val  Ile Gly His Ser Met  Gln Asn Cys 
    3335                 3340                 3345             


Val Leu  Lys Leu Lys Val Asp  Thr Ala Asn Pro Lys  Thr Pro Lys 
    3350                 3355                 3360             


Tyr Lys  Phe Val Arg Ile Gln  Pro Gly Gln Thr Phe  Ser Val Leu 
    3365                 3370                 3375             


Ala Cys  Tyr Asn Gly Ser Pro  Ser Gly Val Tyr Gln  Cys Ala Met 
    3380                 3385                 3390             


Arg Pro  Asn Phe Thr Ile Lys  Gly Ser Phe Leu Asn  Gly Ser Cys 
    3395                 3400                 3405             


Gly Ser  Val Gly Phe Asn Ile  Asp Tyr Asp Cys Val  Ser Phe Cys 
    3410                 3415                 3420             


Tyr Met  His His Met Glu Leu  Pro Thr Gly Val His  Ala Gly Thr 
    3425                 3430                 3435             


Asp Leu  Glu Gly Asn Phe Tyr  Gly Pro Phe Val Asp  Arg Gln Thr 
    3440                 3445                 3450             


Ala Gln  Ala Ala Gly Thr Asp  Thr Thr Ile Thr Val  Asn Val Leu 
    3455                 3460                 3465             


Ala Trp  Leu Tyr Ala Ala Val  Ile Asn Gly Asp Arg  Trp Phe Leu 
    3470                 3475                 3480             


Asn Arg  Phe Thr Thr Thr Leu  Asn Asp Phe Asn Leu  Val Ala Met 
    3485                 3490                 3495             


Lys Tyr  Asn Tyr Glu Pro Leu  Thr Gln Asp His Val  Asp Ile Leu 
    3500                 3505                 3510             


Gly Pro  Leu Ser Ala Gln Thr  Gly Ile Ala Val Leu  Asp Met Cys 
    3515                 3520                 3525             


Ala Ser  Leu Lys Glu Leu Leu  Gln Asn Gly Met Asn  Gly Arg Thr 
    3530                 3535                 3540             


Ile Leu  Gly Ser Ala Leu Leu  Glu Asp Glu Phe Thr  Pro Phe Asp 
    3545                 3550                 3555             


Val Val  Arg Gln Cys Ser Gly  Val Thr Phe Gln Ser  Ala Val Lys 
    3560                 3565                 3570             


Arg Thr  Ile Lys Gly Thr His  His Trp Leu Leu Leu  Thr Ile Leu 
    3575                 3580                 3585             


Thr Ser  Leu Leu Val Leu Val  Gln Ser Thr Gln Trp  Ser Leu Phe 
    3590                 3595                 3600             


Phe Phe  Leu Tyr Glu Asn Ala  Phe Leu Pro Phe Ala  Met Gly Ile 
    3605                 3610                 3615             


Ile Ala  Met Ser Ala Phe Ala  Met Met Phe Val Lys  His Lys His 
    3620                 3625                 3630             


Ala Phe  Leu Cys Leu Phe Leu  Leu Pro Ser Leu Ala  Thr Val Ala 
    3635                 3640                 3645             


Tyr Phe  Asn Met Val Tyr Met  Pro Ala Ser Trp Val  Met Arg Ile 
    3650                 3655                 3660             


Met Thr  Trp Leu Asp Met Val  Asp Thr Ser Leu Ser  Gly Phe Lys 
    3665                 3670                 3675             


Leu Lys  Asp Cys Val Met Tyr  Ala Ser Ala Val Val  Leu Leu Ile 
    3680                 3685                 3690             


Leu Met  Thr Ala Arg Thr Val  Tyr Asp Asp Gly Ala  Arg Arg Val 
    3695                 3700                 3705             


Trp Thr  Leu Met Asn Val Leu  Thr Leu Val Tyr Lys  Val Tyr Tyr 
    3710                 3715                 3720             


Gly Asn  Ala Leu Asp Gln Ala  Ile Ser Met Trp Ala  Leu Ile Ile 
    3725                 3730                 3735             


Ser Val  Thr Ser Asn Tyr Ser  Gly Val Val Thr Thr  Val Met Phe 
    3740                 3745                 3750             


Leu Ala  Arg Gly Ile Val Phe  Met Cys Val Glu Tyr  Cys Pro Ile 
    3755                 3760                 3765             


Phe Phe  Ile Thr Gly Asn Thr  Leu Gln Cys Ile Met  Leu Val Tyr 
    3770                 3775                 3780             


Cys Phe  Leu Gly Tyr Phe Cys  Thr Cys Tyr Phe Gly  Leu Phe Cys 
    3785                 3790                 3795             


Leu Leu  Asn Arg Tyr Phe Arg  Leu Thr Leu Gly Val  Tyr Asp Tyr 
    3800                 3805                 3810             


Leu Val  Ser Thr Gln Glu Phe  Arg Tyr Met Asn Ser  Gln Gly Leu 
    3815                 3820                 3825             


Leu Pro  Pro Lys Asn Ser Ile  Asp Ala Phe Lys Leu  Asn Ile Lys 
    3830                 3835                 3840             


Leu Leu  Gly Val Gly Gly Lys  Pro Cys Ile Lys Val  Ala Thr Val 
    3845                 3850                 3855             


Gln Ser  Lys Met Ser Asp Val  Lys Cys Thr Ser Val  Val Leu Leu 
    3860                 3865                 3870             


Ser Val  Leu Gln Gln Leu Arg  Val Glu Ser Ser Ser  Lys Leu Trp 
    3875                 3880                 3885             


Ala Gln  Cys Val Gln Leu His  Asn Asp Ile Leu Leu  Ala Lys Asp 
    3890                 3895                 3900             


Thr Thr  Glu Ala Phe Glu Lys  Met Val Ser Leu Leu  Ser Val Leu 
    3905                 3910                 3915             


Leu Ser  Met Gln Gly Ala Val  Asp Ile Asn Lys Leu  Cys Glu Glu 
    3920                 3925                 3930             


Met Leu  Asp Asn Arg Ala Thr  Leu Gln Ala Ile Ala  Ser Glu Phe 
    3935                 3940                 3945             


Ser Ser  Leu Pro Ser Tyr Ala  Ala Phe Ala Thr Ala  Gln Glu Ala 
    3950                 3955                 3960             


Tyr Glu  Gln Ala Val Ala Asn  Gly Asp Ser Glu Val  Val Leu Lys 
    3965                 3970                 3975             


Lys Leu  Lys Lys Ser Leu Asn  Val Ala Lys Ser Glu  Phe Asp Arg 
    3980                 3985                 3990             


Asp Ala  Ala Met Gln Arg Lys  Leu Glu Lys Met Ala  Asp Gln Ala 
    3995                 4000                 4005             


Met Thr  Gln Met Tyr Lys Gln  Ala Arg Ser Glu Asp  Lys Arg Ala 
    4010                 4015                 4020             


Lys Val  Thr Ser Ala Met Gln  Thr Met Leu Phe Thr  Met Leu Arg 
    4025                 4030                 4035             


Lys Leu  Asp Asn Asp Ala Leu  Asn Asn Ile Ile Asn  Asn Ala Arg 
    4040                 4045                 4050             


Asp Gly  Cys Val Pro Leu Asn  Ile Ile Pro Leu Thr  Thr Ala Ala 
    4055                 4060                 4065             


Lys Leu  Met Val Val Ile Pro  Asp Tyr Asn Thr Tyr  Lys Asn Thr 
    4070                 4075                 4080             


Cys Asp  Gly Thr Thr Phe Thr  Tyr Ala Ser Ala Leu  Trp Glu Ile 
    4085                 4090                 4095             


Gln Gln  Val Val Asp Ala Asp  Ser Lys Ile Val Gln  Leu Ser Glu 
    4100                 4105                 4110             


Ile Ser  Met Asp Asn Ser Pro  Asn Leu Ala Trp Pro  Leu Ile Val 
    4115                 4120                 4125             


Thr Ala  Leu Arg Ala Asn Ser  Ala Val Lys Leu Gln  Asn Asn Glu 
    4130                 4135                 4140             


Leu Ser  Pro Val Ala Leu Arg  Gln Met Ser Cys Ala  Ala Gly Thr 
    4145                 4150                 4155             


Thr Gln  Thr Ala Cys Thr Asp  Asp Asn Ala Leu Ala  Tyr Tyr Asn 
    4160                 4165                 4170             


Thr Thr  Lys Gly Gly Arg Phe  Val Leu Ala Leu Leu  Ser Asp Leu 
    4175                 4180                 4185             


Gln Asp  Leu Lys Trp Ala Arg  Phe Pro Lys Ser Asp  Gly Thr Gly 
    4190                 4195                 4200             


Thr Ile  Tyr Thr Glu Leu Glu  Pro Pro Cys Arg Phe  Val Thr Asp 
    4205                 4210                 4215             


Thr Pro  Lys Gly Pro Lys Val  Lys Tyr Leu Tyr Phe  Ile Lys Gly 
    4220                 4225                 4230             


Leu Asn  Asn Leu Asn Arg Gly  Met Val Leu Gly Ser  Leu Ala Ala 
    4235                 4240                 4245             


Thr Val  Arg Leu Gln Ala Gly  Asn Ala Thr Glu Val  Pro Ala Asn 
    4250                 4255                 4260             


Ser Thr  Val Leu Ser Phe Cys  Ala Phe Ala Val Asp  Ala Ala Lys 
    4265                 4270                 4275             


Ala Tyr  Lys Asp Tyr Leu Ala  Ser Gly Gly Gln Pro  Ile Thr Asn 
    4280                 4285                 4290             


Cys Val  Lys Met Leu Cys Thr  His Thr Gly Thr Gly  Gln Ala Ile 
    4295                 4300                 4305             


Thr Val  Thr Pro Glu Ala Asn  Met Asp Gln Glu Ser  Phe Gly Gly 
    4310                 4315                 4320             


Ala Ser  Cys Cys Leu Tyr Cys  Arg Cys His Ile Asp  His Pro Asn 
    4325                 4330                 4335             


Pro Lys  Gly Phe Cys Asp Leu  Lys Gly Lys Tyr Val  Gln Ile Pro 
    4340                 4345                 4350             


Thr Thr  Cys Ala Asn Asp Pro  Val Gly Phe Thr Leu  Lys Asn Thr 
    4355                 4360                 4365             


Val Cys  Thr Val Cys Gly Met  Trp Lys Gly Tyr Gly  Cys Ser Cys 
    4370                 4375                 4380             


Asp Gln  Leu Arg Glu Pro Met  Leu Gln Ser Ala Asp  Ala Gln Ser 
    4385                 4390                 4395             


Phe Leu  Asn Arg Val Cys Gly  Val Ser Ala Ala Arg  Leu Thr Pro 
    4400                 4405                 4410             


Cys Gly  Thr Gly Thr Ser Thr  Asp Val Val Tyr Arg  Ala Phe Asp 
    4415                 4420                 4425             


Ile Tyr  Asn Asp Lys Val Ala  Gly Phe Ala Lys Phe  Leu Lys Thr 
    4430                 4435                 4440             


Asn Cys  Cys Arg Phe Gln Glu  Lys Asp Glu Asp Asp  Asn Leu Ile 
    4445                 4450                 4455             


Asp Ser  Tyr Phe Val Val Lys  Arg His Thr Phe Ser  Asn Tyr Gln 
    4460                 4465                 4470             


His Glu  Glu Thr Ile Tyr Asn  Leu Leu Lys Asp Cys  Pro Ala Val 
    4475                 4480                 4485             


Ala Lys  His Asp Phe Phe Lys  Phe Arg Ile Asp Gly  Asp Met Val 
    4490                 4495                 4500             


Pro His  Ile Ser Arg Gln Arg  Leu Thr Lys Tyr Thr  Met Ala Asp 
    4505                 4510                 4515             


Leu Val  Tyr Ala Leu Arg His  Phe Asp Glu Gly Asn  Cys Asp Thr 
    4520                 4525                 4530             


Leu Lys  Glu Ile Leu Val Thr  Tyr Asn Cys Cys Asp  Asp Asp Tyr 
    4535                 4540                 4545             


Phe Asn  Lys Lys Asp Trp Tyr  Asp Phe Val Glu Asn  Pro Asp Ile 
    4550                 4555                 4560             


Leu Arg  Val Tyr Ala Asn Leu  Gly Glu Arg Val Arg  Gln Ala Leu 
    4565                 4570                 4575             


Leu Lys  Thr Val Gln Phe Cys  Asp Ala Met Arg Asn  Ala Gly Ile 
    4580                 4585                 4590             


Val Gly  Val Leu Thr Leu Asp  Asn Gln Asp Leu Asn  Gly Asn Trp 
    4595                 4600                 4605             


Tyr Asp  Phe Gly Asp Phe Ile  Gln Thr Thr Pro Gly  Ser Gly Val 
    4610                 4615                 4620             


Pro Val  Val Asp Ser Tyr Tyr  Ser Leu Leu Met Pro  Ile Leu Thr 
    4625                 4630                 4635             


Leu Thr  Arg Ala Leu Thr Ala  Glu Ser His Val Asp  Thr Asp Leu 
    4640                 4645                 4650             


Thr Lys  Pro Tyr Ile Lys Trp  Asp Leu Leu Lys Tyr  Asp Phe Thr 
    4655                 4660                 4665             


Glu Glu  Arg Leu Lys Leu Phe  Asp Arg Tyr Phe Lys  Tyr Trp Asp 
    4670                 4675                 4680             


Gln Thr  Tyr His Pro Asn Cys  Val Asn Cys Leu Asp  Asp Arg Cys 
    4685                 4690                 4695             


Ile Leu  His Cys Ala Asn Phe  Asn Val Leu Phe Ser  Thr Val Phe 
    4700                 4705                 4710             


Pro Pro  Thr Ser Phe Gly Pro  Leu Val Arg Lys Ile  Phe Val Asp 
    4715                 4720                 4725             


Gly Val  Pro Phe Val Val Ser  Thr Gly Tyr His Phe  Arg Glu Leu 
    4730                 4735                 4740             


Gly Val  Val His Asn Gln Asp  Val Asn Leu His Ser  Ser Arg Leu 
    4745                 4750                 4755             


Ser Phe  Lys Glu Leu Leu Val  Tyr Ala Ala Asp Pro  Ala Met His 
    4760                 4765                 4770             


Ala Ala  Ser Gly Asn Leu Leu  Leu Asp Lys Arg Thr  Thr Cys Phe 
    4775                 4780                 4785             


Ser Val  Ala Ala Leu Thr Asn  Asn Val Ala Phe Gln  Thr Val Lys 
    4790                 4795                 4800             


Pro Gly  Asn Phe Asn Lys Asp  Phe Tyr Asp Phe Ala  Val Ser Lys 
    4805                 4810                 4815             


Gly Phe  Phe Lys Glu Gly Ser  Ser Val Glu Leu Lys  His Phe Phe 
    4820                 4825                 4830             


Phe Ala  Gln Asp Gly Asn Ala  Ala Ile Ser Asp Tyr  Asp Tyr Tyr 
    4835                 4840                 4845             


Arg Tyr  Asn Leu Pro Thr Met  Cys Asp Ile Arg Gln  Leu Leu Phe 
    4850                 4855                 4860             


Val Val  Glu Val Val Asp Lys  Tyr Phe Asp Cys Tyr  Asp Gly Gly 
    4865                 4870                 4875             


Cys Ile  Asn Ala Asn Gln Val  Ile Val Asn Asn Leu  Asp Lys Ser 
    4880                 4885                 4890             


Ala Gly  Phe Pro Phe Asn Lys  Trp Gly Lys Ala Arg  Leu Tyr Tyr 
    4895                 4900                 4905             


Asp Ser  Met Ser Tyr Glu Asp  Gln Asp Ala Leu Phe  Ala Tyr Thr 
    4910                 4915                 4920             


Lys Arg  Asn Val Ile Pro Thr  Ile Thr Gln Met Asn  Leu Lys Tyr 
    4925                 4930                 4935             


Ala Ile  Ser Ala Lys Asn Arg  Ala Arg Thr Val Ala  Gly Val Ser 
    4940                 4945                 4950             


Ile Cys  Ser Thr Met Thr Asn  Arg Gln Phe His Gln  Lys Leu Leu 
    4955                 4960                 4965             


Lys Ser  Ile Ala Ala Thr Arg  Gly Ala Thr Val Val  Ile Gly Thr 
    4970                 4975                 4980             


Ser Lys  Phe Tyr Gly Gly Trp  His Asn Met Leu Lys  Thr Val Tyr 
    4985                 4990                 4995             


Ser Asp  Val Glu Asn Pro His  Leu Met Gly Trp Asp  Tyr Pro Lys 
    5000                 5005                 5010             


Cys Asp  Arg Ala Met Pro Asn  Met Leu Arg Ile Met  Ala Ser Leu 
    5015                 5020                 5025             


Val Leu  Ala Arg Lys His Thr  Thr Cys Cys Ser Leu  Ser His Arg 
    5030                 5035                 5040             


Phe Tyr  Arg Leu Ala Asn Glu  Cys Ala Gln Val Leu  Ser Glu Met 
    5045                 5050                 5055             


Val Met  Cys Gly Gly Ser Leu  Tyr Val Lys Pro Gly  Gly Thr Ser 
    5060                 5065                 5070             


Ser Gly  Asp Ala Thr Thr Ala  Tyr Ala Asn Ser Val  Phe Asn Ile 
    5075                 5080                 5085             


Cys Gln  Ala Val Thr Ala Asn  Val Asn Ala Leu Leu  Ser Thr Asp 
    5090                 5095                 5100             


Gly Asn  Lys Ile Ala Asp Lys  Tyr Val Arg Asn Leu  Gln His Arg 
    5105                 5110                 5115             


Leu Tyr  Glu Cys Leu Tyr Arg  Asn Arg Asp Val Asp  Thr Asp Phe 
    5120                 5125                 5130             


Val Asn  Glu Phe Tyr Ala Tyr  Leu Arg Lys His Phe  Ser Met Met 
    5135                 5140                 5145             


Ile Leu  Ser Asp Asp Ala Val  Val Cys Phe Asn Ser  Thr Tyr Ala 
    5150                 5155                 5160             


Ser Gln  Gly Leu Val Ala Ser  Ile Lys Asn Phe Lys  Ser Val Leu 
    5165                 5170                 5175             


Tyr Tyr  Gln Asn Asn Val Phe  Met Ser Glu Ala Lys  Cys Trp Thr 
    5180                 5185                 5190             


Glu Thr  Asp Leu Thr Lys Gly  Pro His Glu Phe Cys  Ser Gln His 
    5195                 5200                 5205             


Thr Met  Leu Val Lys Gln Gly  Asp Asp Tyr Val Tyr  Leu Pro Tyr 
    5210                 5215                 5220             


Pro Asp  Pro Ser Arg Ile Leu  Gly Ala Gly Cys Phe  Val Asp Asp 
    5225                 5230                 5235             


Ile Val  Lys Thr Asp Gly Thr  Leu Met Ile Glu Arg  Phe Val Ser 
    5240                 5245                 5250             


Leu Ala  Ile Asp Ala Tyr Pro  Leu Thr Lys His Pro  Asn Gln Glu 
    5255                 5260                 5265             


Tyr Ala  Asp Val Phe His Leu  Tyr Leu Gln Tyr Ile  Arg Lys Leu 
    5270                 5275                 5280             


His Asp  Glu Leu Thr Gly His  Met Leu Asp Met Tyr  Ser Val Met 
    5285                 5290                 5295             


Leu Thr  Asn Asp Asn Thr Ser  Arg Tyr Trp Glu Pro  Glu Phe Tyr 
    5300                 5305                 5310             


Glu Ala  Met Tyr Thr Pro His  Thr Val Leu Gln Ala  Val Gly Ala 
    5315                 5320                 5325             


Cys Val  Leu Cys Asn Ser Gln  Thr Ser Leu Arg Cys  Gly Ala Cys 
    5330                 5335                 5340             


Ile Arg  Arg Pro Phe Leu Cys  Cys Lys Cys Cys Tyr  Asp His Val 
    5345                 5350                 5355             


Ile Ser  Thr Ser His Lys Leu  Val Leu Ser Val Asn  Pro Tyr Val 
    5360                 5365                 5370             


Cys Asn  Ala Pro Gly Cys Asp  Val Thr Asp Val Thr  Gln Leu Tyr 
    5375                 5380                 5385             


Leu Gly  Gly Met Ser Tyr Tyr  Cys Lys Ser His Lys  Pro Pro Ile 
    5390                 5395                 5400             


Ser Phe  Pro Leu Cys Ala Asn  Gly Gln Val Phe Gly  Leu Tyr Lys 
    5405                 5410                 5415             


Asn Thr  Cys Val Gly Ser Asp  Asn Val Thr Asp Phe  Asn Ala Ile 
    5420                 5425                 5430             


Ala Thr  Cys Asp Trp Thr Asn  Ala Gly Asp Tyr Ile  Leu Ala Asn 
    5435                 5440                 5445             


Thr Cys  Thr Glu Arg Leu Lys  Leu Phe Ala Ala Glu  Thr Leu Lys 
    5450                 5455                 5460             


Ala Thr  Glu Glu Thr Phe Lys  Leu Ser Tyr Gly Ile  Ala Thr Val 
    5465                 5470                 5475             


Arg Glu  Val Leu Ser Asp Arg  Glu Leu His Leu Ser  Trp Glu Val 
    5480                 5485                 5490             


Gly Lys  Pro Arg Pro Pro Leu  Asn Arg Asn Tyr Val  Phe Thr Gly 
    5495                 5500                 5505             


Tyr Arg  Val Thr Lys Asn Ser  Lys Val Gln Ile Gly  Glu Tyr Thr 
    5510                 5515                 5520             


Phe Glu  Lys Gly Asp Tyr Gly  Asp Ala Val Val Tyr  Arg Gly Thr 
    5525                 5530                 5535             


Thr Thr  Tyr Lys Leu Asn Val  Gly Asp Tyr Phe Val  Leu Thr Ser 
    5540                 5545                 5550             


His Thr  Val Met Pro Leu Ser  Ala Pro Thr Leu Val  Pro Gln Glu 
    5555                 5560                 5565             


His Tyr  Val Arg Ile Thr Gly  Leu Tyr Pro Thr Leu  Asn Ile Ser 
    5570                 5575                 5580             


Asp Glu  Phe Ser Ser Asn Val  Ala Asn Tyr Gln Lys  Val Gly Met 
    5585                 5590                 5595             


Gln Lys  Tyr Ser Thr Leu Gln  Gly Pro Pro Gly Thr  Gly Lys Ser 
    5600                 5605                 5610             


His Phe  Ala Ile Gly Leu Ala  Leu Tyr Tyr Pro Ser  Ala Arg Ile 
    5615                 5620                 5625             


Val Tyr  Thr Ala Cys Ser His  Ala Ala Val Asp Ala  Leu Cys Glu 
    5630                 5635                 5640             


Lys Ala  Leu Lys Tyr Leu Pro  Ile Asp Lys Cys Ser  Arg Ile Ile 
    5645                 5650                 5655             


Pro Ala  Arg Ala Arg Val Glu  Cys Phe Asp Lys Phe  Lys Val Asn 
    5660                 5665                 5670             


Ser Thr  Leu Glu Gln Tyr Val  Phe Cys Thr Val Asn  Ala Leu Pro 
    5675                 5680                 5685             


Glu Thr  Thr Ala Asp Ile Val  Val Phe Asp Glu Ile  Ser Met Ala 
    5690                 5695                 5700             


Thr Asn  Tyr Asp Leu Ser Val  Val Asn Ala Arg Leu  Arg Ala Lys 
    5705                 5710                 5715             


His Tyr  Val Tyr Ile Gly Asp  Pro Ala Gln Leu Pro  Ala Pro Arg 
    5720                 5725                 5730             


Thr Leu  Leu Thr Lys Gly Thr  Leu Glu Pro Glu Tyr  Phe Asn Ser 
    5735                 5740                 5745             


Val Cys  Arg Leu Met Lys Thr  Ile Gly Pro Asp Met  Phe Leu Gly 
    5750                 5755                 5760             


Thr Cys  Arg Arg Cys Pro Ala  Glu Ile Val Asp Thr  Val Ser Ala 
    5765                 5770                 5775             


Leu Val  Tyr Asp Asn Lys Leu  Lys Ala His Lys Asp  Lys Ser Ala 
    5780                 5785                 5790             


Gln Cys  Phe Lys Met Phe Tyr  Lys Gly Val Ile Thr  His Asp Val 
    5795                 5800                 5805             


Ser Ser  Ala Ile Asn Arg Pro  Gln Ile Gly Val Val  Arg Glu Phe 
    5810                 5815                 5820             


Leu Thr  Arg Asn Pro Ala Trp  Arg Lys Ala Val Phe  Ile Ser Pro 
    5825                 5830                 5835             


Tyr Asn  Ser Gln Asn Ala Val  Ala Ser Lys Ile Leu  Gly Leu Pro 
    5840                 5845                 5850             


Thr Gln  Thr Val Asp Ser Ser  Gln Gly Ser Glu Tyr  Asp Tyr Val 
    5855                 5860                 5865             


Ile Phe  Thr Gln Thr Thr Glu  Thr Ala His Ser Cys  Asn Val Asn 
    5870                 5875                 5880             


Arg Phe  Asn Val Ala Ile Thr  Arg Ala Lys Val Gly  Ile Leu Cys 
    5885                 5890                 5895             


Ile Met  Ser Asp Arg Asp Leu  Tyr Asp Lys Leu Gln  Phe Thr Ser 
    5900                 5905                 5910             


Leu Glu  Ile Pro Arg Arg Asn  Val Ala Thr Leu Gln  Ala Glu Asn 
    5915                 5920                 5925             


Val Thr  Gly Leu Phe Lys Asp  Cys Ser Lys Val Ile  Thr Gly Leu 
    5930                 5935                 5940             


His Pro  Thr Gln Ala Pro Thr  His Leu Ser Val Asp  Thr Lys Phe 
    5945                 5950                 5955             


Lys Thr  Glu Gly Leu Cys Val  Asp Ile Pro Gly Ile  Pro Lys Asp 
    5960                 5965                 5970             


Met Thr  Tyr Arg Arg Leu Ile  Ser Met Met Gly Phe  Lys Met Asn 
    5975                 5980                 5985             


Tyr Gln  Val Asn Gly Tyr Pro  Asn Met Phe Ile Thr  Arg Glu Glu 
    5990                 5995                 6000             


Ala Ile  Arg His Val Arg Ala  Trp Ile Gly Phe Asp  Val Glu Gly 
    6005                 6010                 6015             


Cys His  Ala Thr Arg Glu Ala  Val Gly Thr Asn Leu  Pro Leu Gln 
    6020                 6025                 6030             


Leu Gly  Phe Ser Thr Gly Val  Asn Leu Val Ala Val  Pro Thr Gly 
    6035                 6040                 6045             


Tyr Val  Asp Thr Pro Asn Asn  Thr Asp Phe Ser Arg  Val Ser Ala 
    6050                 6055                 6060             


Lys Pro  Pro Pro Gly Asp Gln  Phe Lys His Leu Ile  Pro Leu Met 
    6065                 6070                 6075             


Tyr Lys  Gly Leu Pro Trp Asn  Val Val Arg Ile Lys  Ile Val Gln 
    6080                 6085                 6090             


Met Leu  Ser Asp Thr Leu Lys  Asn Leu Ser Asp Arg  Val Val Phe 
    6095                 6100                 6105             


Val Leu  Trp Ala His Gly Phe  Glu Leu Thr Ser Met  Lys Tyr Phe 
    6110                 6115                 6120             


Val Lys  Ile Gly Pro Glu Arg  Thr Cys Cys Leu Cys  Asp Arg Arg 
    6125                 6130                 6135             


Ala Thr  Cys Phe Ser Thr Ala  Ser Asp Thr Tyr Ala  Cys Trp His 
    6140                 6145                 6150             


His Ser  Ile Gly Phe Asp Tyr  Val Tyr Asn Pro Phe  Met Ile Asp 
    6155                 6160                 6165             


Val Gln  Gln Trp Gly Phe Thr  Gly Asn Leu Gln Ser  Asn His Asp 
    6170                 6175                 6180             


Leu Tyr  Cys Gln Val His Gly  Asn Ala His Val Ala  Ser Cys Asp 
    6185                 6190                 6195             


Ala Ile  Met Thr Arg Cys Leu  Ala Val His Glu Cys  Phe Val Lys 
    6200                 6205                 6210             


Arg Val  Asp Trp Thr Ile Glu  Tyr Pro Ile Ile Gly  Asp Glu Leu 
    6215                 6220                 6225             


Lys Ile  Asn Ala Ala Cys Arg  Lys Val Gln His Met  Val Val Lys 
    6230                 6235                 6240             


Ala Ala  Leu Leu Ala Asp Lys  Phe Pro Val Leu His  Asp Ile Gly 
    6245                 6250                 6255             


Asn Pro  Lys Ala Ile Lys Cys  Val Pro Gln Ala Asp  Val Glu Trp 
    6260                 6265                 6270             


Lys Phe  Tyr Asp Ala Gln Pro  Cys Ser Asp Lys Ala  Tyr Lys Ile 
    6275                 6280                 6285             


Glu Glu  Leu Phe Tyr Ser Tyr  Ala Thr His Ser Asp  Lys Phe Thr 
    6290                 6295                 6300             


Asp Gly  Val Cys Leu Phe Trp  Asn Cys Asn Val Asp  Arg Tyr Pro 
    6305                 6310                 6315             


Ala Asn  Ser Ile Val Cys Arg  Phe Asp Thr Arg Val  Leu Ser Asn 
    6320                 6325                 6330             


Leu Asn  Leu Pro Gly Cys Asp  Gly Gly Ser Leu Tyr  Val Asn Lys 
    6335                 6340                 6345             


His Ala  Phe His Thr Pro Ala  Phe Asp Lys Ser Ala  Phe Val Asn 
    6350                 6355                 6360             


Leu Lys  Gln Leu Pro Phe Phe  Tyr Tyr Ser Asp Ser  Pro Cys Glu 
    6365                 6370                 6375             


Ser His  Gly Lys Gln Val Val  Ser Asp Ile Asp Tyr  Val Pro Leu 
    6380                 6385                 6390             


Lys Ser  Ala Thr Cys Ile Thr  Arg Cys Asn Leu Gly  Gly Ala Val 
    6395                 6400                 6405             


Cys Arg  His His Ala Asn Glu  Tyr Arg Leu Tyr Leu  Asp Ala Tyr 
    6410                 6415                 6420             


Asn Met  Met Ile Ser Ala Gly  Phe Ser Leu Trp Val  Tyr Lys Gln 
    6425                 6430                 6435             


Phe Asp  Thr Tyr Asn Leu Trp  Asn Thr Phe Thr Arg  Leu Gln Ser 
    6440                 6445                 6450             


Leu Glu  Asn Val Ala Phe Asn  Val Val Asn Lys Gly  His Phe Asp 
    6455                 6460                 6465             


Gly Gln  Gln Gly Glu Val Pro  Val Ser Ile Ile Asn  Asn Thr Val 
    6470                 6475                 6480             


Tyr Thr  Lys Val Asp Gly Val  Asp Val Glu Leu Phe  Glu Asn Lys 
    6485                 6490                 6495             


Thr Thr  Leu Pro Val Asn Val  Ala Phe Glu Leu Trp  Ala Lys Arg 
    6500                 6505                 6510             


Asn Ile  Lys Pro Val Pro Glu  Val Lys Ile Leu Asn  Asn Leu Gly 
    6515                 6520                 6525             


Val Asp  Ile Ala Ala Asn Thr  Val Ile Trp Asp Tyr  Lys Arg Asp 
    6530                 6535                 6540             


Ala Pro  Ala His Ile Ser Thr  Ile Gly Val Cys Ser  Met Thr Asp 
    6545                 6550                 6555             


Ile Ala  Lys Lys Pro Thr Glu  Thr Ile Cys Ala Pro  Leu Thr Val 
    6560                 6565                 6570             


Phe Phe  Asp Gly Arg Val Asp  Gly Gln Val Asp Leu  Phe Arg Asn 
    6575                 6580                 6585             


Ala Arg  Asn Gly Val Leu Ile  Thr Glu Gly Ser Val  Lys Gly Leu 
    6590                 6595                 6600             


Gln Pro  Ser Val Gly Pro Lys  Gln Ala Ser Leu Asn  Gly Val Thr 
    6605                 6610                 6615             


Leu Ile  Gly Glu Ala Val Lys  Thr Gln Phe Asn Tyr  Tyr Lys Lys 
    6620                 6625                 6630             


Val Asp  Gly Val Val Gln Gln  Leu Pro Glu Thr Tyr  Phe Thr Gln 
    6635                 6640                 6645             


Ser Arg  Asn Leu Gln Glu Phe  Lys Pro Arg Ser Gln  Met Glu Ile 
    6650                 6655                 6660             


Asp Phe  Leu Glu Leu Ala Met  Asp Glu Phe Ile Glu  Arg Tyr Lys 
    6665                 6670                 6675             


Leu Glu  Gly Tyr Ala Phe Glu  His Ile Val Tyr Gly  Asp Phe Ser 
    6680                 6685                 6690             


His Ser  Gln Leu Gly Gly Leu  His Leu Leu Ile Gly  Leu Ala Lys 
    6695                 6700                 6705             


Arg Phe  Lys Glu Ser Pro Phe  Glu Leu Glu Asp Phe  Ile Pro Met 
    6710                 6715                 6720             


Asp Ser  Thr Val Lys Asn Tyr  Phe Ile Thr Asp Ala  Gln Thr Gly 
    6725                 6730                 6735             


Ser Ser  Lys Cys Val Cys Ser  Val Ile Asp Leu Leu  Leu Asp Asp 
    6740                 6745                 6750             


Phe Val  Glu Ile Ile Lys Ser  Gln Asp Leu Ser Val  Val Ser Lys 
    6755                 6760                 6765             


Val Val  Lys Val Thr Ile Asp  Tyr Thr Glu Ile Ser  Phe Met Leu 
    6770                 6775                 6780             


Trp Cys  Lys Asp Gly His Val  Glu Thr Phe Tyr Pro  Lys Leu Gln 
    6785                 6790                 6795             


Ser Ser  Gln Ala Trp Gln Pro  Gly Val Ala Met Pro  Asn Leu Tyr 
    6800                 6805                 6810             


Lys Met  Gln Arg Met Leu Leu  Glu Lys Cys Asp Leu  Gln Asn Tyr 
    6815                 6820                 6825             


Gly Asp  Ser Ala Thr Leu Pro  Lys Gly Ile Met Met  Asn Val Ala 
    6830                 6835                 6840             


Lys Tyr  Thr Gln Leu Cys Gln  Tyr Leu Asn Thr Leu  Thr Leu Ala 
    6845                 6850                 6855             


Val Pro  Tyr Asn Met Arg Val  Ile His Phe Gly Ala  Gly Ser Asp 
    6860                 6865                 6870             


Lys Gly  Val Ala Pro Gly Thr  Ala Val Leu Arg Gln  Trp Leu Pro 
    6875                 6880                 6885             


Thr Gly  Thr Leu Leu Val Asp  Ser Asp Leu Asn Asp  Phe Val Ser 
    6890                 6895                 6900             


Asp Ala  Asp Ser Thr Leu Ile  Gly Asp Cys Ala Thr  Val His Thr 
    6905                 6910                 6915             


Ala Asn  Lys Trp Asp Leu Ile  Ile Ser Asp Met Tyr  Asp Pro Lys 
    6920                 6925                 6930             


Thr Lys  Asn Val Thr Lys Glu  Asn Asp Ser Lys Glu  Gly Phe Phe 
    6935                 6940                 6945             


Thr Tyr  Ile Cys Gly Phe Ile  Gln Gln Lys Leu Ala  Leu Gly Gly 
    6950                 6955                 6960             


Ser Val  Ala Ile Lys Ile Thr  Glu His Ser Trp Asn  Ala Asp Leu 
    6965                 6970                 6975             


Tyr Lys  Leu Met Gly His Phe  Ala Trp Trp Thr Ala  Phe Val Thr 
    6980                 6985                 6990             


Asn Val  Asn Ala Ser Ser Ser  Glu Ala Phe Leu Ile  Gly Cys Asn 
    6995                 7000                 7005             


Tyr Leu  Gly Lys Pro Arg Glu  Gln Ile Asp Gly Tyr  Val Met His 
    7010                 7015                 7020             


Ala Asn  Tyr Ile Phe Trp Arg  Asn Thr Asn Pro Ile  Gln Leu Ser 
    7025                 7030                 7035             


Ser Tyr  Ser Leu Phe Asp Met  Ser Lys Phe Pro Leu  Lys Leu Arg 
    7040                 7045                 7050             


Gly Thr  Ala Val Met Ser Leu  Lys Glu Gly Gln Ile  Asn Asp Met 
    7055                 7060                 7065             


Ile Leu  Ser Leu Leu Ser Lys  Gly Arg Leu Ile Ile  Arg Glu Asn 
    7070                 7075                 7080             


Asn Arg  Val Val Ile Ser Ser  Asp Val Leu Val Asn  Asn 
    7085                 7090                 7095     



<210> 3
<211> 1273
<212> PRT
<213> betacoronavirus SARS coronavirus 2

<400> 3
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val
 1               5                  10                  15
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe
            20                  25                  30
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu
        35                  40                  45
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp
    50                  55                  60
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp
65                  70                  75                  80
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu
                85                  90                  95
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser
            100                 105                 110
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile
        115                 120                 125
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr
    130                 135                 140
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr
145                 150                 155                 160
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu
                165                 170                 175
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe
            180                 185                 190
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr
        195                 200                 205
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu
    210                 215                 220
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr
225                 230                 235                 240
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser
                245                 250                 255
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro
            260                 265                 270
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala
        275                 280                 285
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys
    290                 295                 300
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val
305                 310                 315                 320
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys
                325                 330                 335
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala
            340                 345                 350
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu
        355                 360                 365
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro
    370                 375                 380
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe
385                 390                 395                 400
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly
                405                 410                 415
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys
            420                 425                 430
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn
        435                 440                 445
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe
    450                 455                 460
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys
465                 470                 475                 480
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly
                485                 490                 495
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val
            500                 505                 510
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys
        515                 520                 525
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn
    530                 535                 540
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu
545                 550                 555                 560
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val
                565                 570                 575
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe
            580                 585                 590
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val
        595                 600                 605
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile
    610                 615                 620
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser
625                 630                 635                 640
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val
                645                 650                 655
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala
            660                 665                 670
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala
        675                 680                 685
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser
    690                 695                 700
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile
705                 710                 715                 720
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val
                725                 730                 735
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu
            740                 745                 750
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr
        755                 760                 765
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln
    770                 775                 780
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe
785                 790                 795                 800
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser
                805                 810                 815
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly
            820                 825                 830
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp
        835                 840                 845
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu
    850                 855                 860
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly
865                 870                 875                 880
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile
                885                 890                 895
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr
            900                 905                 910
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn
        915                 920                 925
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala
    930                 935                 940
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn
945                 950                 955                 960
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val
                965                 970                 975
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln
            980                 985                 990
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val
        995                 1000                1005
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu
    1010                1015                1020
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val
1025                1030                1035                1040
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala
                1045                1050                1055
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu
            1060                1065                1070
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His
        1075                1080                1085
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val
    1090                1095                1100
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr
1105                1110                1115                1120
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr
                1125                1130                1135
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu
            1140                1145                1150
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp
        1155                1160                1165
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp
    1170                1175                1180
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu
1185                1190                1195                1200
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile
                1205                1210                1215
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile
            1220                1225                1230
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys
        1235                1240                1245
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val
    1250                1255                1260
Leu Lys Gly Val Lys Leu His Tyr Thr
1265                1270

<210> 4
<211> 220
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic surface glycoprotein RBD [SARS-CoV-2
      Wuhan seafood market pneumonia virus]; GenBank:
      QHD43416.1; January 23, 2020

<400> 4
Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg
 1               5                  10                  15
Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val
            20                  25                  30
Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys
        35                  40                  45
Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn
    50                  55                  60
Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile
65                  70                  75                  80
Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro
                85                  90                  95
Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp
            100                 105                 110
Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys
        115                 120                 125
Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln
    130                 135                 140
Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe
145                 150                 155                 160
Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln
                165                 170                 175
Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala
            180                 185                 190
Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys
        195                 200                 205
Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly
    210                 215                 220

<210> 5
<211> 72
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Receptor Binding Motif (RBM) in surface
      glycoprotein RBD [SARS-CoV-2 Wuhan seafood market
      pneumonia virus]; GenBank: QHD43416.1; January 23,
      2020

<400> 5
Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu
 1               5                  10                  15
Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile
            20                  25                  30
Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu
        35                  40                  45
Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr
    50                  55                  60
Asn Gly Val Gly Tyr Gln Pro Tyr
65                  70

<210> 6
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic SARS-CoV-2 CH1-CH3 LS G1m17 IgHG1*01

<400> 6
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300
Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr
305                 310                 315                 320
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330

<210> 7
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic SARS-CoV-2 CH1-CH3 LS, ALE G1m17
      IgHG1*01

<400> 7
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110
Pro Ala Pro Glu Leu Leu Ala Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205
Lys Ala Leu Pro Leu Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300
Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser His Tyr Thr
305                 310                 315                 320
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330

<210> 8
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic SARS-CoV-2 CL IgLC*01

<400> 8
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser
 1               5                  10                  15
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp
            20                  25                  30
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro
        35                  40                  45
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn
    50                  55                  60
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys
65                  70                  75                  80
Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val
                85                  90                  95
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser
            100                 105

<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic SARS-CoV-2 CL (CK) k1m3 IgKC*01

<400> 9
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
 1               5                  10                  15
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
            20                  25                  30
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
        35                  40                  45
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
    50                  55                  60
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65                  70                  75                  80
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                85                  90                  95
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105

<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 CDRH1

<400> 10
Gly Gly Ile Phe Asn Thr Tyr Thr
 1               5

<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 variant_1 CDRH1

<400> 11
Gly Gly Ile Phe Ser Thr Tyr Thr
 1               5

<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 CDRH2

<400> 12
Ile Ile Leu Met Ser Gly Met Ala
 1               5

<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 variant_1 CDRH2

<400> 13
Ile Ile Leu Ile Ser Gly Ile Ala
 1               5

<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 variant_2 CDRH2

<400> 14
Ile Ile Leu Met Ser Gly Lys Ala
 1               5

<210> 15
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 CDRH3

<400> 15
Ala Arg Gly Phe Asn Gly Asn Tyr Tyr Gly Trp Gly Asp Asp Asp Ala
 1               5                  10                  15
Phe Asp Ile


<210> 16
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 VH

<400> 16
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Asn Thr Tyr
            20                  25                  30
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Arg Ile Ile Leu Met Ser Gly Met Ala Asn Tyr Ala Gln Lys Ile
    50                  55                  60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Gly Phe Asn Gly Asn Tyr Tyr Gly Trp Gly Asp Asp Asp Ala
            100                 105                 110
Phe Asp Ile Ser Gly Gln Gly Thr Leu Val Thr Val Tyr Ser
        115                 120                 125

<210> 17
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 VH_v1

<400> 17
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Asn Thr Tyr
            20                  25                  30
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Arg Ile Ile Leu Met Ser Gly Met Ala Asn Tyr Ala Gln Lys Ile
    50                  55                  60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Gly Phe Asn Gly Asn Tyr Tyr Gly Trp Gly Asp Asp Asp Ala
            100                 105                 110
Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Tyr Ser
        115                 120                 125

<210> 18
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 VH_v2

<400> 18
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Asn Thr Tyr
            20                  25                  30
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Arg Ile Ile Leu Ile Ser Gly Ile Ala Asn Tyr Ala Gln Lys Ile
    50                  55                  60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Gly Phe Asn Gly Asn Tyr Tyr Gly Trp Gly Asp Asp Asp Ala
            100                 105                 110
Phe Asp Ile Ser Gly Gln Gly Thr Leu Val Thr Val Tyr Ser
        115                 120                 125

<210> 19
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 VH_v3

<400> 19
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Ser Thr Tyr
            20                  25                  30
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Arg Ile Ile Leu Met Ser Gly Met Ala Asn Tyr Ala Gln Lys Ile
    50                  55                  60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Gly Phe Asn Gly Asn Tyr Tyr Gly Trp Gly Asp Asp Asp Ala
            100                 105                 110
Phe Asp Ile Ser Gly Gln Gly Thr Leu Val Thr Val Tyr Ser
        115                 120                 125

<210> 20
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 VH_v4

<400> 20
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Asn Thr Tyr
            20                  25                  30
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Arg Ile Ile Leu Met Ser Gly Met Ala Asn Tyr Ala Gln Lys Ile
    50                  55                  60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Gly Phe Asn Gly Asn Tyr Tyr Gly Trp Gly Asp Asp Asp Ala
            100                 105                 110
Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 21
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 VH_v5

<400> 21
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Asn Thr Tyr
            20                  25                  30
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Arg Ile Ile Leu Met Ser Gly Lys Ala Asn Tyr Ala Gln Lys Ile
    50                  55                  60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Gly Phe Asn Gly Asn Tyr Tyr Gly Trp Gly Asp Asp Asp Ala
            100                 105                 110
Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 22
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 VH_v6

<400> 22
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Asn Thr Tyr
            20                  25                  30
Thr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Arg Ile Ile Leu Ile Ser Gly Ile Ala Asn Tyr Ala Gln Lys Ile
    50                  55                  60
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Gly Phe Asn Gly Asn Tyr Tyr Gly Trp Gly Asp Asp Asp Ala
            100                 105                 110
Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 CDRL1

<400> 23
Asn Ser Asn Ile Gly Ala Gly Tyr Asp
 1               5

<210> 24
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic S2X259 CDRL2

<400> 24
Gly Asn Ser
 1

<210> 25
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X259 CDRL3

<400> 25
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Pro Asn Trp Val
 1               5                  10

<210> 26
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X259 VL

<400> 26
Gln Thr Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15
Arg Val Thr Ile Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Ala Gly
            20                  25                  30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45
Leu Ile Cys Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95
Leu Ser Gly Pro Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105                 110
Leu


<210> 27
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X259 VL_v1

<400> 27
Gln Thr Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15
Arg Val Thr Ile Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Ala Gly
            20                  25                  30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45
Leu Ile Ser Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95
Leu Ser Gly Pro Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105                 110
Leu


<210> 28
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X259 VL_v2

<400> 28
Gln Thr Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15
Arg Val Thr Ile Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Ala Gly
            20                  25                  30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45
Leu Ile Ala Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95
Leu Ser Gly Pro Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105                 110
Leu


<210> 29
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X259 VL_v3

<400> 29
Gln Thr Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15
Arg Val Thr Ile Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Ala Gly
            20                  25                  30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95
Leu Ser Gly Pro Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105                 110
Leu


<210> 30
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X259 VL_v4

<400> 30
Gln Thr Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15
Arg Val Thr Ile Ser Cys Thr Gly Ser Asn Ser Asn Ile Gly Ala Gly
            20                  25                  30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45
Leu Ile Val Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95
Leu Ser Gly Pro Asn Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105                 110
Leu


<210> 31
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v1 mAb VH

<400> 31
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Ser Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Leu Ser Ser Gly Tyr Ser Gly Tyr Ala Gly Asn Tyr Trp Gly Gln
            100                 105                 110
Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 32
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v1 mAb CDRH1

<400> 32
Gly Phe Thr Phe Ser Ser Tyr Trp
 1               5

<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v1 mAb CDRH2

<400> 33
Ile Lys Gln Asp Gly Ser Glu Lys
 1               5

<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v1 mAb CDRH3

<400> 34
Ala Leu Ser Ser Gly Tyr Ser Gly Tyr Ala Gly Asn Tyr
 1               5                  10

<210> 35
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v1 mAb VL

<400> 35
Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly
 1               5                  10                  15
Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ser Gly
            20                  25                  30
His Tyr Pro Tyr Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Thr
        35                  40                  45
Leu Ile Tyr Asp Thr Ser Asn Lys His Ser Trp Thr Pro Ala Arg Phe
    50                  55                  60
Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Ala
65                  70                  75                  80
Arg Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Ser Tyr Ser Gly
                85                  90                  95
Ala Arg Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110

<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v1 mAb CDRL1

<400> 36
Thr Gly Ala Val Thr Ser Gly His Tyr
 1               5

<210> 37
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v1 mAb CDRL2

<400> 37
Asp Thr Ser
 1

<210> 38
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v1 mAb CDRL3

<400> 38
Leu Leu Ser Tyr Ser Gly Ala Arg Gly Val
 1               5                  10

<210> 39
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v2 mAb VH

<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Ser Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Phe Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Leu Ser Ser Gly Tyr Ser Gly Tyr Ala Gly Asn Tyr Trp Gly Gln
            100                 105                 110
Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 40
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v2 mAb CDRH1

<400> 40
Gly Phe Thr Phe Ser Ser Tyr Phe Met Asn
 1               5                  10

<210> 41
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v3 mAb VH

<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Ser Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Leu Ser Ser Gly Tyr Ser Gly Tyr Ala Gly Asn Tyr Trp Gly Gln
            100                 105                 110
Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 42
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v3 mAb CDRH2

<400> 42
Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys
 1               5                  10                  15
Gly


<210> 43
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v4 mAb VH

<400> 43
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Ser Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Phe Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Leu Ser Ser Gly Tyr Ser Gly Tyr Ala Gly Asn Tyr Trp Gly Gln
            100                 105                 110
Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 44
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v5 mAb VH

<400> 44
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Ser Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Phe Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Asn Ile Lys Gln Asp Ala Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Leu Ser Ser Gly Tyr Ser Gly Tyr Ala Gly Asn Tyr Trp Gly Gln
            100                 105                 110
Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 45
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v5 mAb CDRH2

<400> 45
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Ser Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Leu Ser Ser Gly Tyr Ser Gly Tyr Ala Gly Asn Tyr Trp Gly Gln
            100                 105                 110
Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 46
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H13-v6 mAb CDRH1

<400> 46
Gly Phe Thr Phe Ser Ser Tyr Tyr Met Asn
 1               5                  10

<210> 47
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v1 mAb VH

<400> 47
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Thr Gly Ser Glu Thr Tyr Tyr Tyr Asp Ser Ser Gly Pro
            100                 105                 110
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 48
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v1 mAb CDRH1

<400> 48
Gly Phe Thr Phe Ser Asn Ala Trp Met Ser
 1               5                  10

<210> 49
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v1 mAb CDRH2

<400> 49
Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala Pro
 1               5                  10                  15
Val Lys Gly


<210> 50
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v1 mAb CDRH3

<400> 50
Gly Ser Glu Thr Tyr Tyr Tyr Asp Ser Ser Gly Pro Phe Asp Tyr
 1               5                  10                  15

<210> 51
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v1 mAb VL

<400> 51
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
 1               5                  10                  15
Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn
            20                  25                  30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val
        35                  40                  45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65                  70                  75                  80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
                85                  90                  95
Ser Asn Gln Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110

<210> 52
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v1 mAb CDRL1

<400> 52
Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln
 1               5                  10

<210> 53
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v1 mAb CDRL2

<400> 53
Glu Asp Asn Gln Arg Pro Ser
 1               5

<210> 54
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v1 mAb CDRL3

<400> 54
Gln Ser Tyr Asp Ser Ser Asn Gln Val
 1               5

<210> 55
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v2 mAb VH

<400> 55
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Thr Gly Ser Glu Thr Tyr Tyr Tyr Asp Ser Ser Gly Pro
            100                 105                 110
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 56
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v2 mAb CDRH1

<400> 56
Gly Phe Thr Phe Ser Asn Ala Phe Met Ser
 1               5                  10

<210> 57
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v3 mAb VH

<400> 57
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Arg Ile Lys Ser Lys Thr Glu Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Thr Gly Ser Glu Thr Tyr Tyr Tyr Asp Ser Ser Gly Pro
            100                 105                 110
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 58
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v3 mAb CDRH2

<400> 58
Arg Ile Lys Ser Lys Thr Glu Gly Gly Thr Thr Asp Tyr Ala Ala Pro
 1               5                  10                  15
Val Lys Gly


<210> 59
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v4 mAb VH

<400> 59
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Arg Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Thr Gly Ser Glu Thr Tyr Tyr Tyr Asp Ser Ser Gly Pro
            100                 105                 110
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 60
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v4 mAb CDRH2

<400> 60
Arg Ile Lys Ser Lys Thr Asp Ala Gly Thr Thr Asp Tyr Ala Ala Pro
 1               5                  10                  15
Val Lys Gly


<210> 61
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v5 mAb VH

<400> 61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Arg Ile Lys Ser Lys Thr Glu Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Thr Gly Ser Glu Thr Tyr Tyr Tyr Asp Ser Ser Gly Pro
            100                 105                 110
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 62
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v6 mAb VH

<400> 62
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Arg Ile Lys Ser Lys Thr Glu Gly Gly Thr Thr Asp Tyr Ala Ala
    50                  55                  60
Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Thr Gly Ser Glu Thr Tyr Tyr Tyr Asp Ser Ser Gly Pro
            100                 105                 110
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 63
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2H14-v6 mAb CDRH1

<400> 63
Gly Phe Thr Phe Ser Asn Ala Tyr Met Ser
 1               5                  10

<210> 64
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2A4-v1 mAb VH

<400> 64
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Val Trp Trp Leu Arg Gly Ser Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110
Thr Leu Val Thr Val Ser Ser
        115

<210> 65
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2A4-v1 mAb CDRH1

<400> 65
Gly Phe Thr Phe Ser Ser Tyr Trp
 1               5

<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2A4-v1 mAb CDRH2

<400> 66
Ile Lys Gln Asp Gly Ser Glu Lys
 1               5

<210> 67
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2A4-v1 mAb CDRH3

<400> 67
Ala Arg Val Trp Trp Leu Arg Gly Ser Phe Asp Tyr
 1               5                  10

<210> 68
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2A4-v1 mAb VL

<400> 68
Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys
 1               5                  10                  15
Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn
            20                  25                  30
Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val
        35                  40                  45
Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60
Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly
65                  70                  75                  80
Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser
                85                  90                  95
Ser Asn His Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110

<210> 69
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2A4-v1 mAb CDRL1

<400> 69
Ser Gly Ser Ile Ala Ser Asn Tyr
 1               5

<210> 70
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2A4-v1 mAb CDRL2

<400> 70
Glu Asp Asn
 1

<210> 71
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2A4-v1 mAb CDRL3

<400> 71
Gln Ser Tyr Asp Ser Ser Asn His Val Val
 1               5                  10

<210> 72
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v1 VH

<400> 72
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Trp Ile Ser Ala Tyr Lys Gly Asn Thr Asn Tyr Ala Gln Lys Leu
    50                  55                  60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Pro Asp Tyr Gln Val Leu Gly Tyr Asp Phe Trp Ile Gly Tyr
            100                 105                 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Ile Val Ser Ser
        115                 120                 125

<210> 73
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v1 CDRH1

<400> 73
Gly Tyr Thr Phe Thr Asn Tyr Gly
 1               5

<210> 74
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v1 CDRH2

<400> 74
Ile Ser Ala Tyr Lys Gly Asn Thr
 1               5

<210> 75
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v1 CDRH3

<400> 75
Ala Arg Pro Asp Tyr Gln Val Leu Gly Tyr Asp Phe Trp Ile Gly Tyr
 1               5                  10                  15
Tyr Gly Met Asp Val
            20

<210> 76
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v1 VL

<400> 76
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
        35                  40                  45
Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95
Leu Ser Gly Ser Glu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105                 110
Leu


<210> 77
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v1 CDRL1

<400> 77
Ser Ser Asn Ile Gly Ala Gly Tyr Asp
 1               5

<210> 78
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v1 CDRL2

<400> 78
Gly Asn Thr
 1

<210> 79
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v1 CDRL3

<400> 79
Gln Ser Tyr Asp Ser Ser Leu Ser Gly Ser Glu Val Val
 1               5                  10

<210> 80
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v2 CDRH1

<400> 80
Gly Tyr Thr Phe Thr Asn Tyr Gly Ile Ser
 1               5                  10

<210> 81
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v2 CDRH2

<400> 81
Trp Ile Ser Ala Tyr Lys Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln
 1               5                  10                  15
Gly


<210> 82
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v2 mAb CDRH3

<400> 82
Pro Asp Tyr Gln Val Leu Gly Tyr Asp Phe Trp Ile Gly Tyr Tyr Gly
 1               5                  10                  15
Met Asp Val


<210> 83
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v3 VH

<400> 83
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Phe Ile Ser Ala Tyr Lys Gly Asn Thr Asn Tyr Ala Gln Lys Leu
    50                  55                  60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Pro Asp Tyr Gln Val Leu Gly Tyr Asp Phe Trp Ile Gly Tyr
            100                 105                 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Ile Val Ser Ser
        115                 120                 125

<210> 84
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v3 CDRH1

<400> 84
Phe Ile Ser Ala Tyr Lys Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln
 1               5                  10                  15
Gly


<210> 85
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v4 VH

<400> 85
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Trp Ile Ser Ala Tyr Lys Gly Asn Thr Asn Tyr Ala Gln Lys Leu
    50                  55                  60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Pro Asp Tyr Gln Val Leu Gly Tyr Asp Phe Phe Ile Gly Tyr
            100                 105                 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Ile Val Ser Ser
        115                 120                 125

<210> 86
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v4 CDRH3

<400> 86
Ala Arg Pro Asp Tyr Gln Val Leu Gly Tyr Asp Phe Phe Ile Gly Tyr
 1               5                  10                  15
Tyr Gly Met Asp Val
            20

<210> 87
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v5 CDRH3

<400> 87
Pro Asp Tyr Gln Val Leu Gly Tyr Asp Phe Phe Ile Gly Tyr Tyr Gly
 1               5                  10                  15
Met Asp Val


<210> 88
<211> 128
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v6 VH

<400> 88
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Phe Ile Ser Ala Tyr Lys Gly Asn Thr Asn Tyr Ala Gln Lys Leu
    50                  55                  60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Pro Asp Tyr Gln Val Leu Gly Tyr Asp Phe Phe Ala Gly Tyr
            100                 105                 110
Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Ile Val Ser Ser
        115                 120                 125

<210> 89
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v6 CDRH3

<400> 89
Ala Arg Pro Asp Tyr Gln Val Leu Gly Tyr Asp Phe Phe Ala Gly Tyr
 1               5                  10                  15
Tyr Gly Met Asp Val
            20

<210> 90
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v7 CDRH3

<400> 90
Pro Asp Tyr Gln Val Leu Gly Tyr Asp Phe Phe Ala Gly Tyr Tyr Gly
 1               5                  10                  15
Met Asp Val


<210> 91
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v8 CDRL1

<400> 91
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His
 1               5                  10

<210> 92
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2X35-v8 CDRL2

<400> 92
Gly Asn Thr Asn Arg Pro Ser
 1               5

<210> 93
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309-v2 VH

<400> 93
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr
            20                  25                  30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Trp Ile Ser Thr Tyr Gln Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr
65                  70                  75                  80
Met Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly
            100                 105                 110
Gly Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 94
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309-v2 CDRH1

<400> 94
Gly Tyr Pro Phe Thr Ser Tyr Gly
 1               5

<210> 95
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309-v2 CDRH2

<400> 95
Ile Ser Thr Tyr Gln Gly Asn Thr
 1               5

<210> 96
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309-v2 CDRH3

<400> 96
Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly
 1               5                  10                  15
Gly Phe Asp Asn
            20

<210> 97
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309-v2 VL

<400> 97
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Thr
            20                  25                  30
Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asp Thr Ser Leu
                85                  90                  95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 98
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309-v2 CDRL1

<400> 98
Gln Thr Val Ser Ser Thr Ser
 1               5

<210> 99
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309-v2 CDRL2

<400> 99
Gly Ala Ser
 1

<210> 100
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309-v2 CDRL3

<400> 100
Gln Gln His Asp Thr Ser Leu Thr
 1               5

<210> 101
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309 VH

<400> 101
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Pro Phe Thr Ser Tyr
            20                  25                  30
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Trp Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Thr Thr Gly Tyr
65                  70                  75                  80
Met Glu Leu Arg Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly
            100                 105                 110
Gly Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 102
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309 CDRH1

<400> 102
Gly Tyr Pro Phe Thr Ser Tyr Gly
 1               5

<210> 103
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309 CDRH2

<400> 103
Ile Ser Thr Tyr Asn Gly Asn Thr
 1               5

<210> 104
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309 CDRH3

<400> 104
Ala Arg Asp Tyr Thr Arg Gly Ala Trp Phe Gly Glu Ser Leu Ile Gly
 1               5                  10                  15
Gly Phe Asp Asn
            20

<210> 105
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309 VL

<400> 105
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Ser Thr
            20                  25                  30
Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Asp Thr Ser Leu
                85                  90                  95
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 106
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309 CDRL1

<400> 106
Gln Thr Val Ser Ser Thr Ser
 1               5

<210> 107
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309 CDRL2

<400> 107
Gly Ala Ser
 1

<210> 108
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S309 CDRL3

<400> 108
Gln Gln His Asp Thr Ser Leu Thr
 1               5

<210> 109
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH1

<400> 109
Gly Phe Thr Phe Thr Ser Ser Ala
 1               5

<210> 110
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH2

<400> 110
Ile Val Val Gly Ser Gly Asn Thr
 1               5

<210> 111
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3

<400> 111
Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Gly Phe Asp Ile
 1               5                  10

<210> 112
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3 variant 1

<400> 112
Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Ala Phe Asp Ile
 1               5                  10

<210> 113
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3 variant 2

<400> 113
Pro Tyr Ser Ser Gly Gly Ser Ser Ser Asp Gly Phe Asp Ile
 1               5                  10

<210> 114
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3 variant 3

<400> 114
Pro Tyr Pro Ser Gly Gly Ser Pro Ser Asp Gly Phe Asp Ile
 1               5                  10

<210> 115
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3 variant 4

<400> 115
Pro Tyr Ala Ser Gly Gly Ser Ala Ser Asp Gly Phe Asp Ile
 1               5                  10

<210> 116
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3 variant 5

<400> 116
Pro Tyr Cys Ser Gly Gly Ser Cys Ser Glu Gly Phe Asp Ile
 1               5                  10

<210> 117
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3 with N-terminal
      adjacent alanine and serine amino acids

<400> 117
Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Gly Phe Asp Ile
 1               5                  10                  15

<210> 118
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3 variant 1 with
      N-terminal adjacent alanine and serine amino acids

<400> 118
Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Ala Phe Asp Ile
 1               5                  10                  15

<210> 119
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3 variant 2 with
      N-terminal adjacent alanine and serine amino acids

<400> 119
Ala Ser Pro Tyr Ser Ser Gly Gly Ser Ser Ser Asp Gly Phe Asp Ile
 1               5                  10                  15

<210> 120
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3 variant 3 with
      N-terminal adjacent alanine and serine amino acids

<400> 120
Ala Ser Pro Tyr Pro Ser Gly Gly Ser Pro Ser Asp Gly Phe Asp Ile
 1               5                  10                  15

<210> 121
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3 variant 4 with
      N-terminal adjacent alanine and serine amino acids

<400> 121
Ala Ser Pro Tyr Ala Ser Gly Gly Ser Ala Ser Asp Gly Phe Asp Ile
 1               5                  10                  15

<210> 122
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRH3 variant 5 with
      N-terminal adjacent alanine and serine amino acids

<400> 122
Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Glu Gly Phe Asp Ile
 1               5                  10                  15

<210> 123
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VH

<400> 123
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
            20                  25                  30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val
        35                  40                  45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
His Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Gly Phe Asp Ile
            100                 105                 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 124
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VH_v1

<400> 124
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
            20                  25                  30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
His Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Gly Phe Asp Ile
            100                 105                 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 125
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VH_v2

<400> 125
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
            20                  25                  30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val
        35                  40                  45
Gly Tyr Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
His Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Gly Phe Asp Ile
            100                 105                 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 126
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VH_v3

<400> 126
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
            20                  25                  30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val
        35                  40                  45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
His Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Ala Phe Asp Ile
            100                 105                 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 127
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VH_v4

<400> 127
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
            20                  25                  30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val
        35                  40                  45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
His Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ser Pro Tyr Ser Ser Gly Gly Ser Ser Ser Asp Gly Phe Asp Ile
            100                 105                 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 128
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VH_v5

<400> 128
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
            20                  25                  30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val
        35                  40                  45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
His Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ser Pro Tyr Pro Ser Gly Gly Ser Pro Ser Asp Gly Phe Asp Ile
            100                 105                 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 129
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VH_v6

<400> 129
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
            20                  25                  30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val
        35                  40                  45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
His Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Met
65                  70                  75                  80
Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95
Ser Pro Tyr Ala Ser Gly Gly Ser Ala Ser Asp Gly Phe Asp Ile Trp
            100                 105                 110
Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 130
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VH_v7

<400> 130
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
            20                  25                  30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val
        35                  40                  45
Gly Phe Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
His Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Glu Gly Phe Asp Ile
            100                 105                 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 131
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VH_v8

<400> 131
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
            20                  25                  30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val
        35                  40                  45
Gly Trp Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
His Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Glu Gly Phe Asp Ile
            100                 105                 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 132
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VH_v9

<400> 132
Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Pro Gly Thr
 1               5                  10                  15
Ser Val Arg Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Ser Ser
            20                  25                  30
Ala Val Gln Trp Val Arg Gln Ala Arg Gly Gln Arg Leu Glu Trp Val
        35                  40                  45
Gly Ala Ile Val Val Gly Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe
    50                  55                  60
His Glu Arg Val Thr Ile Thr Arg Asp Met Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Ser Pro Tyr Cys Ser Gly Gly Ser Cys Ser Asp Gly Phe Asp Ile
            100                 105                 110
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 133
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRL1

<400> 133
Gln Ser Val Ser Ser Ser Tyr
 1               5

<210> 134
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRL2

<400> 134
Gly Ala Ser
 1

<210> 135
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRL3

<400> 135
Gln Gln Tyr Val Gly Leu Thr Gly Trp Thr
 1               5                  10

<210> 136
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRL3 variant 1

<400> 136
Gln Gln Tyr Val Gly Leu Thr Gly Phe Thr
 1               5                  10

<210> 137
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 CDRL3 variant 2

<400> 137
Gln Gln Tyr Val Gly Leu Thr Gly Tyr Thr
 1               5                  10

<210> 138
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VL

<400> 138
Asp Ile Val Leu Thr Gln Thr Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
            20                  25                  30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Gly Leu Thr
                85                  90                  95
Gly Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 139
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VL_v1

<400> 139
Asp Ile Val Leu Thr Gln Thr Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
            20                  25                  30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu
        35                  40                  45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Gly Leu Thr
                85                  90                  95
Gly Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 140
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VL_v2

<400> 140
Asp Ile Val Leu Thr Gln Thr Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
            20                  25                  30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Gly Leu Thr
                85                  90                  95
Gly Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 141
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2E12 VL_v3

<400> 141
Asp Ile Val Leu Thr Gln Thr Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
            20                  25                  30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Val Gly Leu Thr
                85                  90                  95
Gly Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 142
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2M11-v1 VH

<400> 142
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr
            20                  25                  30
Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Trp Ile Asn Pro Ile Ser Ser Gly Thr Ser Tyr Ala Gln Thr Phe
    50                  55                  60
Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Ile Thr Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Ala Ala Pro Phe Tyr Asp Phe Trp Ser Gly Tyr Ser Tyr Phe
            100                 105                 110
Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125

<210> 143
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2M11-v1 CDRH1

<400> 143
Gly Tyr Thr Phe Thr Gly Tyr Tyr
 1               5

<210> 144
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2M11-v1 CDRH2

<400> 144
Ile Asn Pro Ile Ser Ser Gly Thr
 1               5

<210> 145
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2M11-v1 CDRH3

<400> 145
Ala Arg Ala Ala Pro Phe Tyr Asp Phe Trp Ser Gly Tyr Ser Tyr Phe
 1               5                  10                  15
Asp Tyr


<210> 146
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2M11-v1 VL

<400> 146
Glu Ile Val Met Met Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser
            20                  25                  30
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Ala
                85                  90                  95
Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 147
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2M11-v1 CDRL1

<400> 147
Gln Ser Val Ser Ser Ser Tyr
 1               5

<210> 148
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2M11-v1 CDRL2

<400> 148
Gly Ala Ser
 1

<210> 149
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S2M11-v1 CDRL3

<400> 149
Gln Gln Tyr Gly Ser Ser Ala Trp Thr
 1               5

<210> 150
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S304 VH

<400> 150
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Asp Met His Trp Val Arg Gln Thr Thr Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ser Thr Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Asp Ser Val Lys
    50                  55                  60
Gly Arg Phe Thr Ile Ser Arg Glu Asp Ala Lys Asn Ser Leu Tyr Leu
65                  70                  75                  80
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95
Arg Gly Asp Ser Ser Gly Tyr Tyr Tyr Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110
Gly Thr Leu Leu Thr Val Ser Ser
        115                 120

<210> 151
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S304 CDRH1

<400> 151
Gly Phe Thr Phe Ser Ser Tyr Asp
 1               5

<210> 152
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S304 CDRH2

<400> 152
Ile Gly Thr Ala Gly Asp Thr
 1               5

<210> 153
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S304 CDRH3

<400> 153
Ala Arg Gly Asp Ser Ser Gly Tyr Tyr Tyr Tyr Phe Asp Tyr
 1               5                  10

<210> 154
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S304 VL

<400> 154
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ala Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Tyr
            20                  25                  30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Val Ser Pro Thr
                85                  90                  95
Tyr Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys
            100                 105

<210> 155
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S304 CDRL1

<400> 155
Gln Ser Ile Gly Ser Tyr
 1               5

<210> 156
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S304 CDRL2

<400> 156
Ala Ala Ser
 1

<210> 157
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S304 CDRL3

<400> 157
Gln Gln Ser Tyr Val Ser Pro Thr Tyr Thr
 1               5                  10

<210> 158
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CR3022 heavy chain variable
      domain

<400> 158
Gln Met Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Glu
 1               5                  10                  15
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Gly Phe Ile Thr Tyr
            20                  25                  30
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met
        35                  40                  45
Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe
    50                  55                  60
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr
65                  70                  75                  80
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95
Ala Gly Gly Ser Gly Ile Ser Thr Pro Met Asp Val Trp Gly Gln Gly
            100                 105                 110
Thr Thr Val Thr Val Ser Ser
        115

<210> 159
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CR3022 light chain variable
      domain

<400> 159
Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30
Ser Ile Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95
Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile
            100                 105                 110
Lys


<210> 160
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence signal peptide from
      Mu-phosphatase

<400> 160
Met Gly Ile Leu Pro Ser Pro Gly Met Pro Ala Leu Leu Ser Leu Val
 1               5                  10                  15
Ser Leu Leu Ser Val Leu Leu Met Gly Cys Val Ala Glu Thr Gly Thr
            20                  25                  30

<210> 161
<211> 71
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Synthetic C-terminal extension
      sequence of SARS-CoV-2 S ectodomain

<400> 161
Gly Ser Gly Arg Glu Asn Leu Tyr Phe Gln Gly Gly Gly Gly Ser Gly
 1               5                  10                  15
Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp
            20                  25                  30
Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Gly Gly Leu Asn
        35                  40                  45
Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly Ser Gly His
    50                  55                  60
His His His His His His His
65                  70

<210> 162
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence S315 VH

<400> 162
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
            20                  25                  30
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Asp Leu Trp Trp Asn Asp Gln Ala His Tyr Tyr Gly Met Asp
            100                 105                 110
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120

<210> 163
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - S315 VL

<400> 163
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
 1               5                  10                  15
Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Phe Pro Asn Gln Tyr Ala
            20                  25                  30
Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Met Leu Ile Tyr
        35                  40                  45
Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Phe Gly Ser
    50                  55                  60
Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Arg Gly Val Gln Ala Glu
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr Val
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105

<210> 164
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - S303 VH

<400> 164
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Thr Tyr
            20                  25                  30
Ser Met Asn Trp Val Arg Gln Thr Pro Gly Lys Arg Leu Gln Trp Val
        35                  40                  45
Ser Ala Ile Ser Gly Ser Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Thr Val Thr Ala Asp Asp Thr Ala Ile Tyr Phe Cys
                85                  90                  95
Ala Arg Glu Arg Asp Asp Ile Phe Pro Met Gly Leu Asn Ala Phe Asp
            100                 105                 110
Ile Trp Gly Gln Gly Ala Met Val Ile Val Ser Ser
        115                 120

<210> 165
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - S303 VL

<400> 165
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Trp
            20                  25                  30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Asp Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Thr Tyr Ser Trp
                85                  90                  95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 166
<211> 129
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - S2D22 VH

<400> 166
Glu Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser
            20                  25                  30
Ala Met His Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Gly Arg Ile Arg Thr Lys Ala Asn Thr Tyr Ala Thr Ala Tyr Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Arg Pro Ala Pro Tyr Asp Phe Leu Ser Asp Tyr Tyr Thr
            100                 105                 110
Gly Glu Gln Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125
Ser


<210> 167
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - S2D22 VL

<400> 167
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
 1               5                  10                  15
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
            20                  25                  30
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu
        35                  40                  45
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
    50                  55                  60
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
65                  70                  75                  80
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                85                  90                  95
Leu Ser Gly Pro Glu Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
            100                 105                 110

<210> 168
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - S2A10 VH

<400> 168
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly
            20                  25                  30
Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser
    50                  55                  60
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Ser Ser Lys Asn Gln Phe
65                  70                  75                  80
Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  95
Cys Ala Arg Gly Ile Lys Asp Ala Tyr Cys Gly Gly Asp Cys Tyr His
            100                 105                 110
Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120                 125

<210> 169
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence -- S2A10 VL

<400> 169
Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln
 1               5                  10                  15
Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
            20                  25                  30
His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
        35                  40                  45
Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
65                  70                  75                  80
Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Thr Ser Asp His
                85                  90                  95
Pro Asn Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
            100                 105

<210> 170
<211> 419
<212> PRT
<213> betacoronavirus SARS coronavirus 2

<400> 170
Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr
 1               5                  10                  15
Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg
            20                  25                  30
Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn
        35                  40                  45
Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu
    50                  55                  60
Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro
65                  70                  75                  80
Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly
                85                  90                  95
Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr
            100                 105                 110
Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp
        115                 120                 125
Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp
    130                 135                 140
His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln
145                 150                 155                 160
Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser
                165                 170                 175
Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn
            180                 185                 190
Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala
        195                 200                 205
Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu
    210                 215                 220
Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln
225                 230                 235                 240
Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys
                245                 250                 255
Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln
            260                 265                 270
Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp
        275                 280                 285
Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile
    290                 295                 300
Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile
305                 310                 315                 320
Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala
                325                 330                 335
Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu
            340                 345                 350
Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro
        355                 360                 365
Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln
    370                 375                 380
Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu
385                 390                 395                 400
Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser
                405                 410                 415
Thr Gln Ala

