                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Craik, Charles S.
       Vincenti, Flavio
 
<120>  METHODS AND ANTIBODIES IN TREATMENT OF FOCAL SEGMENTAL 
       GLOMERULOSCLEROSIS (FSGS)

<130>  UCSF-621WO

<150>  US 63/035,426
<151>  2020-06-05

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Ile Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Pro Gly Gly Pro Leu Asp Asp Ser Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys 
225         


<210>  2
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala 
1               5                   10                  15      


Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Arg Ser Asn Gly Tyr 
            20                  25                  30          


Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu 
        35                  40                  45              


Leu Ile Tyr Leu Gly Ser Ile Arg Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Ser Arg Val 
65                  70                  75                  80  


Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala Leu Gln Thr 
                85                  90                  95      


Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  3
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn 
1               5                   10          


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp 
1               5                   10      


<210>  5
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Pro Gly Gly Pro Leu Asp Asp Ser Phe Asp Ile 
1               5                   10          


<210>  6
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Ser Ser Gln Ser Leu Leu Arg Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  7
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Gly Ser Ile Arg Ala Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gln Ala Leu Gln Thr Pro Phe Thr 
1               5                   


<210>  9
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Arg Cys Met Gln Cys Lys Thr Asn Gly Asp Cys Arg Val Glu Glu 
1               5                   10                  15      


Cys Ala Leu Gly Gln Asp Leu Cys Arg Thr Thr Ile Val Arg Leu Trp 
            20                  25                  30          


Glu Glu Gly Glu Glu Leu Glu Leu Val Glu Lys Ser Cys Thr His Ser 
        35                  40                  45              


Glu Lys Thr Asn Arg Thr Leu Ser Tyr Arg Thr Gly Leu Lys Ile Thr 
    50                  55                  60                  


Ser Leu Thr Glu Val Val Cys Gly Leu Asp Leu Cys Asn Gln Gly Asn 
65                  70                  75                  80  


Ser Gly Arg Ala Val Thr Tyr Ser Arg Ser Arg Tyr Leu Glu Cys Ile 
                85                  90                  95      


Ser Cys Gly Ser Ser Asp Met Ser Cys Glu Arg Gly Arg His Gln Ser 
            100                 105                 110         


Leu Gln Cys Arg Ser Pro Glu Glu Gln Cys Leu Asp Val Val Thr His 
        115                 120                 125             


Trp Ile Gln Glu Gly Glu Glu Gly Arg Pro Lys Asp Asp Arg His Leu 
    130                 135                 140                 


Arg Gly Cys Gly Tyr Leu Pro Gly Cys Pro Gly Ser Asn Gly Phe His 
145                 150                 155                 160 


Asn Asn Asp Thr Phe His Phe Leu Lys Cys Cys Asn Thr Thr Lys Cys 
                165                 170                 175     


Asn Glu Gly Pro Ile Leu Glu Leu Glu Asn Leu Pro Gln Asn Gly Arg 
            180                 185                 190         


Gln Cys Tyr Ser Cys Lys Gly Asn Ser Thr His Gly Cys Ser Ser Glu 
        195                 200                 205             


Glu Thr Phe Leu Ile Asp Cys Arg Gly Pro Met Asn Gln Cys Leu Val 
    210                 215                 220                 


Ala Thr Gly Thr His Glu Pro Lys Asn Gln Ser Tyr Met Val Arg Gly 
225                 230                 235                 240 


Cys Ala Thr Ala Ser Met Cys Gln His Ala His Leu Gly Asp Ala Phe 
                245                 250                 255     


Ser Met Asn His Ile Asp Val Ser Cys Cys Thr Lys Ser Gly Cys Asn 
            260                 265                 270         


His Pro Asp Leu Asp Val Gln Tyr Arg 
        275                 280     


<210>  10
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser 
1               5                   10                  15      


Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser 
        35                  40                  45              


Ser Asn Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly 
    50                  55                  60                  


Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp 
65                  70                  75                  80  


Tyr Ala Val Ser Val Lys Ser Arg Ile Ile Ile Asn Pro Asp Thr Ser 
                85                  90                  95      


Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Asp Pro Gly Gly Pro Leu Asp Asp Ser 
        115                 120                 125             


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  11
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  11

Leu Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Arg 
            20                  25                  30          


Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Ile Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ala Leu Gln Thr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  12
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Glu Asp Tyr Asp Tyr Val Trp Gly Ser Tyr Arg Gln Tyr 
            100                 105                 110         


Pro Ser Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys 
225                 230 


<210>  13
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Leu Gly Tyr Lys Tyr Ala 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Ile Ile Tyr 
        35                  40                  45              


Gln Asp Lys Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr Ser Val 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  14
<211>  681
<212>  DNA
<213>  Homo sapiens

<400>  14
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat      180

aatgattatg cagtatccgt gaaaagtcga ataattatca acccagacac atccaagaac      240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca      300

agagatccgg gggggcctct cgatgatagt tttgatatct ggggccaagg gacaatggtc      360

accgtctcaa gcgcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tccacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtagtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

aaagttgagc ccaaatcttg t                                                681


<210>  15
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  15
cttgatgttg tgatgactca gtctccactc tccctgcccg tcacccctgg agagccggcc       60

tccatctcct gcaggtctag tcagagcctc ctgcgtagta atggatacaa ctatttggat      120

tggtacctgc agaagccagg gcagtctcca cagctcctga tctatttggg ttctattcgg      180

gcctccgggg tccctgacag gttcagtggc agtggatcgg gcacagattt tacactgaga      240

attagcagag tggaggctga ggatgttggg gtttattact gcatgcaagc tctacaaacc      300

ccgttcactt ttggccaggg gaccaagctg gagatcaagc gaactgtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  16
<211>  690
<212>  DNA
<213>  Homo sapiens

<400>  16
caggtgcagc tgcaggagtc ggggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatgag      300

gattatgatt acgtttgggg gagttatcga caatacccca gtcgctactg gggccaggga      360

accctggtca ccgtctcaag cgcctccacc aagggcccat cggtcttccc cctggcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt ccacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtagtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga aagttgagcc caaatcttgt                                       690


<210>  17
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  17
cagtctgtgc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc       60

acctgctctg gagataattt ggggtataaa tatgcttcct ggtatcagca gaagccaggc      120

cagtcccctg tgctgatcat ctatcaagat aagaagcggc cctctgggat ccctgagcga      180

ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccaggctatg      240

gatgaggctg actattactg tcaggcgtgg gacagcagca cttctgtggt attcggcgga      300

gggaccaagc tgaccgtcct aggtcagccc aaggctgccc cctcggtcac tctgttccca      360

ccctcctctg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc      420

tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      480

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc      540

ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      600

agcaccgtgg agaagacagt ggcccctaca gaatgttca                             639


