                         SEQUENCE LISTING

<110>  Columbia University in the City of New York
 
<120>  Compositions and Methods for Inhibition of Lineage Specific 
       Antigens using CRISPR-Based Base Editors

<130>  01001/006850-WO)

<140>  Filed Herewith
<141>  2021-06-03

<150>  63/033,966
<151>  2020-03-06

<150>  63/033,970
<151>  2020-03-06

<150>  63/183,791
<151>  2021-04-05

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  1
gggcccctgt ggggaaacga ggg                                               23


<210>  2
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  2
agggcccctg tggggaaacg agg                                               23


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  3
ccccacaggg gccctggcta tgg                                               23


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  4
agcactcaca cggtgggaga agg                                               23


<210>  5
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  5

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  6
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  6
caggtgcagc tgcagcagcc cggcgccgag gtggtgaagc ccggcgccag cgtgaagatg       60

agctgcaagg ccagcggcta caccttcacc agctactaca tccactggat caagcagacc      120

cccggccagg gcctggagtg ggtgggcgtg atctaccccg gcaacgacga catcagctac      180

aaccagaagt tccagggcaa ggccaccctg accgccgaca agagcagcac caccgcctac      240

atgcagctga gcagcctgac cagcgaggac agcgccgtgt actactgcgc cagggaggtg      300

aggctgaggt acttcgacgt gtggggccag ggcaccaccg tgaccgtgag cagc            354


<210>  7
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe Ser 
            20                  25                  30          


Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln 
        35                  40                  45              


Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  8
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  8
gagatcgtgc tgacccagag ccccggcagc ctggccgtga gccccggcga gagggtgacc       60

atgagctgca agagcagcca gagcgtgttc ttcagcagca gccagaagaa ctacctggcc      120

tggtaccagc agatccccgg ccagagcccc aggctgctga tctactgggc cagcaccagg      180

gagagcggcg tgcccgacag gttcaccggc agcggcagcg gcaccgactt caccctgacc      240

atcagcagcg tgcagcccga ggacctggcc atctactact gccaccagta cctgagcagc      300

aggaccttcg gccagggcac caagctggag atcaagagg                             339


<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  9

Gly Ser Thr Ser Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser 
1               5                   10                  15      


Thr Lys Gly 
            


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  10

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


<210>  11
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  11

Leu Ser Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly 
1               5                   10                  15      


Tyr Leu His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp 
            20                  25                  30          


Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys 
        35                  40                  45              


Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His 
    50                  55                  60                  


Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys 
65                  70                  75                  80  


Lys Ser Arg Leu Thr Asp Val Thr Leu 
                85                  


<210>  12
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  12

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  13
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  13

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Phe 
65                  70                  75                  80  


Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr 
                85                  90                  95      


Leu 
    


<210>  14
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  14

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  15
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  15
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc       60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt      120

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc      180

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgaac      240

atgactcccc gccgccccgg gcccacccgc aagcattacc agccctatgc cccaccacgc      300

gacttcgcag cctatcgctc cagagtgaag ttcagcagga gcgcagacgc ccccgcgtac      360

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat      420

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac      480

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag      540

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc      600

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgc         657


<210>  16
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  16
ctatcaattt ttgatcctcc tccttttaaa gtaactctta caggaggata tttgcatatt       60

tatgaatcac aactttgttg ccagctgaag ttctggttac ccataggatg tgcagccttt      120

gttgtagtct gcattttggg atgcatactt atttgttggc ttacaaaaaa gaagtattca      180

tccagtgtgc acgaccctaa cggtgaatac atgttcatga gagcagtgaa cacagccaaa      240

aaatctagac tcacagatgt gaccctaaga gtgaagttca gcaggagcgc agacgccccc      300

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag      360

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg      420

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac      480

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag      540

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct      600

cgc                                                                    603


<210>  17
<211>  627
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  17
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc       60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagcccttt      120

tgggtgctgg tggtggttgg tggagtcctg gcttgctata gcttgctagt aacagtggcc      180

tttattattt tctgggtgag gagtaagagg agcaggctcc tgcacagtga ctacatgttc      240

atgagagcag tgaacacagc caaaaaatct agactcacag atgtgaccct aagagtgaag      300

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag      360

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct      420

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag      480

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc      540

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc      600

cttcacatgc aggccctgcc ccctcgc                                          627


<210>  18
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  18

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Pro 
            20                  25                  30          


Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe 
        35                  40                  45              


Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly 
    50                  55                  60                  


Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys His 
            100                 105                 110         


Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Val Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr 
        195                 200                 205             


Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
    210                 215                 220                 


Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Leu Ser Asn Ser Ile 
            260                 265                 270         


Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
                325                 330                 335     


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Lys Arg Gly 
            340                 345                 350         


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
        355                 360                 365             


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
    370                 375                 380                 


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            420                 425                 430         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        435                 440                 445             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    450                 455                 460                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
465                 470                 475                 480 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                485                 490                 495     


Met Gln Ala Leu Pro Pro Arg 
            500             


<210>  19
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  19

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Pro 
            20                  25                  30          


Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe 
        35                  40                  45              


Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly 
    50                  55                  60                  


Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys His 
            100                 105                 110         


Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Val Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr 
        195                 200                 205             


Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
    210                 215                 220                 


Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Thr Val Thr Val Ser Ala Leu Ser Asn Ser Ile Met 
            260                 265                 270         


Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr 
        275                 280                 285             


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
    290                 295                 300                 


Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly Ala 
305                 310                 315                 320 


Val His Thr Arg Gly Leu Asp Lys Pro Phe Trp Val Leu Val Val Val 
                325                 330                 335     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            340                 345                 350         


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
        355                 360                 365             


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
    370                 375                 380                 


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys 
385                 390                 395                 400 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
                405                 410                 415     


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
            420                 425                 430         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        435                 440                 445             


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
    450                 455                 460                 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
465                 470                 475                 480 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
                485                 490                 495     


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 


<210>  20
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  20

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Pro 
            20                  25                  30          


Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe 
        35                  40                  45              


Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly 
    50                  55                  60                  


Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys His 
            100                 105                 110         


Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Val Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr 
        195                 200                 205             


Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
    210                 215                 220                 


Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Leu Ser Asn Ser Ile 
            260                 265                 270         


Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Lys Pro Phe Trp Val Leu Val Val 
                325                 330                 335     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            340                 345                 350         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        355                 360                 365             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    370                 375                 380                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg 
385                 390                 395                 400 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
                405                 410                 415     


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
            420                 425                 430         


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
        435                 440                 445             


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
    450                 455                 460                 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
465                 470                 475                 480 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
                485                 490                 495     


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
            500                 505                 510         


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
        515                 520                 525             


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
    530                 535                 540                 


His Met Gln Ala Leu Pro Pro Arg 
545                 550         


<210>  21
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  21

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Pro 
            20                  25                  30          


Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe 
        35                  40                  45              


Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly 
    50                  55                  60                  


Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys His 
            100                 105                 110         


Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Val Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr 
        195                 200                 205             


Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
    210                 215                 220                 


Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Leu Ser Asn Ser Ile 
            260                 265                 270         


Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Trp Leu Pro Ile Gly Cys Ala 
                325                 330                 335     


Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu 
            340                 345                 350         


Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
        355                 360                 365             


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
    370                 375                 380                 


Val Thr Leu Thr Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
385                 390                 395                 400 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                405                 410                 415     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            420                 425                 430         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        435                 440                 445             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    450                 455                 460                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
465                 470                 475                 480 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                485                 490                 495     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            500                 505                 510         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        515                 520                 525             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    530                 535                 540         


<210>  22
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  22

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
            20                  25                  30          


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
        35                  40                  45              


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
    50                  55                  60                  


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
                85                  90                  95      


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
            100                 105                 110         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Gly Ser Thr Ser Gly Ser 
        115                 120                 125             


Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Leu Gln Glu Ser 
    130                 135                 140                 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
145                 150                 155                 160 


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
                165                 170                 175     


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
            180                 185                 190         


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
        195                 200                 205             


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
    210                 215                 220                 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
225                 230                 235                 240 


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
                245                 250                 255     


Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe 
            260                 265                 270         


Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Lys Pro 
305                 310                 315                 320 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
                325                 330                 335     


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Val Lys Phe Ser 
            340                 345                 350         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        355                 360                 365             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    370                 375                 380                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
385                 390                 395                 400 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                405                 410                 415     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            420                 425                 430         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        435                 440                 445             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 


<210>  23
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  23

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Pro 
            20                  25                  30          


Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe 
        35                  40                  45              


Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly 
    50                  55                  60                  


Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys His 
            100                 105                 110         


Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Val Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr 
        195                 200                 205             


Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
    210                 215                 220                 


Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Leu Ser Asn Ser Ile 
            260                 265                 270         


Met Tyr Phe Ser His Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Lys Pro Phe Trp Val Leu Val Val 
                325                 330                 335     


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
            340                 345                 350         


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        355                 360                 365             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    370                 375                 380                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
385                 390                 395             


<210>  24
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  24

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
            20                  25                  30          


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
        35                  40                  45              


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
    50                  55                  60                  


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
                85                  90                  95      


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
            100                 105                 110         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Gly Ser Thr Ser Gly Ser 
        115                 120                 125             


Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Leu Gln Glu Ser 
    130                 135                 140                 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
145                 150                 155                 160 


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
                165                 170                 175     


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
            180                 185                 190         


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
        195                 200                 205             


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
    210                 215                 220                 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
225                 230                 235                 240 


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
                245                 250                 255     


Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe Val Pro Val Phe 
            260                 265                 270         


Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Lys Pro 
305                 310                 315                 320 


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
                325                 330                 335     


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            340                 345                 350         


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        355                 360                 365             


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    370                 375                 380                 


Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  25
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  25

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Ser Leu Ala Val Ser Pro 
            20                  25                  30          


Gly Glu Arg Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe 
        35                  40                  45              


Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly 
    50                  55                  60                  


Gln Ser Pro Arg Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Val Gln Pro Glu Asp Leu Ala Ile Tyr Tyr Cys His 
            100                 105                 110         


Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly 
    130                 135                 140                 


Ser Thr Lys Gly Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val 
145                 150                 155                 160 


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
                165                 170                 175     


Phe Thr Ser Tyr Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly 
            180                 185                 190         


Leu Glu Trp Val Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr 
        195                 200                 205             


Asn Gln Lys Phe Gln Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser 
    210                 215                 220                 


Thr Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ile Glu Val Met Tyr Pro 
            260                 265                 270         


Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His Val 
        275                 280                 285             


Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys 
    290                 295                 300                 


Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
305                 310                 315                 320 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                325                 330                 335     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            340                 345                 350         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        355                 360                 365             


Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
    370                 375                 380                 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
385                 390                 395                 400 


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
                405                 410                 415     


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
            420                 425                 430         


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
        435                 440                 445             


Met Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg 
                


<210>  26
<211>  1568
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  26
ggtgtcgtga gcggccgctg aactggccac catgtggctg cagtctctgc tgctgctggg       60

caccgtggcc tgtagcatca gcgagatcgt gctgacccag agccctggct ctctggctgt      120

gtctcctggc gagcgcgtga ccatgagctg caagagcagc cagagcgtgt tcttcagcag      180

ctcccagaag aactacctgg cctggtatca gcagatcccc ggccagagcc ccagactgct      240

gatctactgg gccagcacca gagaaagcgg cgtgcccgat agattcaccg gcagcggctc      300

tggcaccgac ttcaccctga caatcagcag cgtgcagccc gaggacctgg ccatctacta      360

ctgccaccag tacctgagca gccggacctt tggccagggc accaagctgg aaatcaagcg      420

gggcagcaca agcggcagcg gaaagcctgg atctggcgag ggctctacca agggccaggt      480

gcagctgcag cagcctggcg ccgaagtcgt gaaacctggc gcctccgtga agatgtcctg      540

caaggccagc ggctacacct tcaccagcta ctacatccac tggatcaagc agacccctgg      600

acagggcctg gaatgggtgg gagtgatcta ccccggcaac gacgacatca gctacaacca      660

gaagttccag ggcaaggcca ccctgaccgc cgacaagtct agcaccaccg cctacatgca      720

gctgtccagc ctgaccagcg aggacagcgc cgtgtactac tgcgccagag aagtgcggct      780

gcggtacttc gatgtgtggg gccagggaac caccgtgacc gtgtctagcg ccctgagcaa      840

cagcatcatg tacttcagcc acttcgtgcc cgtgtttctg cccgccaagc ctaccacaac      900

ccctgcccct agacctccta ccccagcccc tacaatcgcc agccagcctc tgtctctgag      960

gcccgaggct tctagaccag ctgctggcgg agccgtgcac accagaggcc tggatatcta     1020

catctgggcc ccactggccg gcacctgtgg cgtgctgctg ctgtctctcg tgatcaccaa     1080

gagaggccgg aagaagctgc tgtacatctt caagcagccc ttcatgcggc ccgtgcagac     1140

cacccaggaa gaggacggct gtagctgccg gttccccgag gaagaagaag ggggctgcga     1200

gctgagagtg aagttcagca gaagcgccga cgcccctgcc tatcagcagg gccagaacca     1260

gctgtacaac gagctgaacc tgggcagacg ggaagagtac gacgtgctgg acaagcggag     1320

aggcagggac cctgagatgg gcggcaagcc cagacggaag aaccctcagg aaggcctgta     1380

taacgaactg cagaaagaca agatggccga ggcctactcc gagatcggaa tgaagggcga     1440

gcggagaaga ggcaagggcc acgatggact gtaccagggc ctgagcaccg ccaccaagga     1500

cacctatgac gccctgcaca tgcaggccct gccccccaga tgaaattcat cgacgttaac     1560

tattctag                                                              1568


<210>  27
<211>  1586
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  27
ggtgtcgtga gcggccgctg aactggccac catgtggctg cagtctctgc tgctgctggg       60

caccgtggcc tgtagcatca gcgagatcgt gctgacccag agccctggct ctctggctgt      120

gtctcctggc gagcgcgtga ccatgagctg caagagcagc cagagcgtgt tcttcagcag      180

ctcccagaag aactacctgg cctggtatca gcagatcccc ggccagagcc ccagactgct      240

gatctactgg gccagcacca gagaaagcgg cgtgcccgat agattcaccg gcagcggctc      300

tggcaccgac ttcaccctga caatcagcag cgtgcagccc gaggacctgg ccatctacta      360

ctgccaccag tacctgagca gccggacctt tggccagggc accaagctgg aaatcaagcg      420

gggcagcaca agcggcagcg gaaagcctgg atctggcgag ggctctacca agggccaggt      480

gcagctgcag cagcctggcg ccgaagtcgt gaaacctggc gcctccgtga agatgtcctg      540

caaggccagc ggctacacct tcaccagcta ctacatccac tggatcaagc agacccctgg      600

acagggcctg gaatgggtgg gagtgatcta ccccggcaac gacgacatca gctacaacca      660

gaagttccag ggcaaggcca ccctgaccgc cgacaagtct agcaccaccg cctacatgca      720

gctgtccagc ctgaccagcg aggacagcgc cgtgtactac tgcgccagag aagtgcggct      780

gcggtacttc gatgtgtggg gccagggaac caccgtgacc gtgtctgccc tgagcaacag      840

catcatgtac ttcagccact tcgtgcccgt gtttctgccc gccaagccta ccacaacccc      900

tgcccctaga cctcctaccc cagcccctac aatcgccagc cagcctctgt ctctgaggcc      960

cgaggcttct agaccagctg ctggcggagc cgtgcacacc agaggactgg acaagccctt     1020

ctgggtgctg gtggtcgtgg gcggagtgct ggcctgttac agcctgctcg tgacagtggc     1080

cttcatcatc ttttgggtgc gcagcaagcg gtctagactg ctgcacagcg actacatgaa     1140

catgaccccc agaaggccag gccccacccg gaagcactat cagccttacg cccctcccag     1200

agacttcgcc gcctaccggt ccagagtgaa gttcagcaga agcgccgacg cccctgccta     1260

tcagcagggc cagaaccagc tgtacaacga gctgaacctg ggcagacggg aagagtacga     1320

cgtgctggac aagagaagag gccgggaccc tgagatgggc ggcaagccca gacggaagaa     1380

ccctcaggaa ggcctgtata acgaactgca gaaagacaag atggccgagg cctactccga     1440

gatcggcatg aagggcgaac ggcggagagg caagggacac gatggactgt accagggcct     1500

gagcaccgcc accaaggaca cctatgacgc cctgcacatg caggccctgc cccccagatg     1560

aaattcatcg acgttaacta ttctag                                          1586


<210>  28
<211>  1715
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  28
ggtgtcgtga gcggccgctg aactggccac catgtggctg cagtctctgc tgctgctggg       60

caccgtggcc tgtagcatca gcgagatcgt gctgacccag agccctggct ctctggctgt      120

gtctcctggc gagcgcgtga ccatgagctg caagagcagc cagagcgtgt tcttcagcag      180

ctcccagaag aactacctgg cctggtatca gcagatcccc ggccagagcc ccagactgct      240

gatctactgg gccagcacca gagaaagcgg cgtgcccgat agattcaccg gcagcggctc      300

tggcaccgac ttcaccctga caatcagcag cgtgcagccc gaggacctgg ccatctacta      360

ctgccaccag tacctgagca gccggacctt tggccagggc accaagctgg aaatcaagcg      420

gggcagcaca agcggcagcg gaaagcctgg atctggcgag ggctctacca agggccaggt      480

gcagctgcag cagcctggcg ccgaagtcgt gaaacctggc gcctccgtga agatgtcctg      540

caaggccagc ggctacacct tcaccagcta ctacatccac tggatcaagc agacccctgg      600

acagggcctg gaatgggtgg gagtgatcta ccccggcaac gacgacatca gctacaacca      660

gaagttccag ggcaaggcca ccctgaccgc cgacaagtct agcaccaccg cctacatgca      720

gctgtccagc ctgaccagcg aggacagcgc cgtgtactac tgcgccagag aagtgcggct      780

gcggtacttc gatgtgtggg gccagggaac caccgtgacc gtgtctagcg ccctgagcaa      840

cagcatcatg tacttcagcc acttcgtgcc cgtgtttctg cccgccaagc ctaccacaac      900

ccctgcccct agacctccta ccccagcccc tacaatcgcc agccagcctc tgtctctgag      960

gcccgaggct tctagaccag ctgctggcgg agccgtgcac accagaggac tggacaagcc     1020

cttctgggtg ctggtggtcg tgggcggagt gctggcctgt tacagcctgc tcgtgacagt     1080

ggccttcatc atcttttggg tgcgcagcaa gcggtctaga ctgctgcaca gcgactacat     1140

gaacatgacc cccagaaggc caggccccac ccggaagcac tatcagcctt acgcccctcc     1200

cagagacttc gccgcctaca gatccaagag aggccggaag aagctgctgt acatcttcaa     1260

gcagcccttc atgcggcccg tgcagaccac ccaggaagag gacggctgta gctgccggtt     1320

ccccgaggaa gaagaagggg gctgcgagct gagagtgaag ttcagcagaa gcgccgacgc     1380

ccctgcctat cagcagggcc agaaccagct gtacaacgag ctgaacctgg gcagacggga     1440

agagtacgac gtgctggaca agagaagagg ccgggaccct gagatgggcg gcaagcccag     1500

acggaagaac cctcaggaag gcctgtataa cgaactgcag aaagacaaga tggccgaggc     1560

ctactccgag atcggaatga agggcgagcg gcggagaggc aagggacacg atggactgta     1620

ccagggcctg agcaccgcca ccaaggacac ctatgacgcc ctgcacatgc aggccctgcc     1680

ccccagatga aattcatcga cgttaactat tctag                                1715


<210>  29
<211>  1436
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  29
ggtgtcgtga gcggccgctg aactggccac catgtggctg cagtctctgc tgctgctggg       60

caccgtggcc tgcagcatca gcatccagat gacccagacc accagcagcc tgagcgccag      120

cctgggcgat agagtgacca tcagctgcag agccagccag gacatcagca agtacctgaa      180

ctggtatcag cagaaacccg acggcaccgt gaagctgctg atctaccaca ccagcagact      240

gcacagcggc gtgccctcta gattttccgg cagcggctcc ggcaccgact acagcctgac      300

catctccaac ctggaacagg aagatatcgc tacctacttc tgtcagcaag gcaacaccct      360

gccctacacc ttcggcggag gcaccaagct ggaaatcggc agcacaagcg gctctggcaa      420

gcctggatct ggcgagggct ctaccaaggg cctgcaggaa tctggccctg gactggtggc      480

ccctagccag agcctgtctg tgacctgtac cgtgtccggc gtgtccctgc ctgactatgg      540

cgtgtcctgg atcagacagc cccccagaaa gggcctggaa tggctgggag tgatctgggg      600

cagcgagaca acctactaca acagcgccct gaagtcccgg ctgaccatca tcaaggacaa      660

ctccaagagc caggtgttcc tgaagatgaa cagcctgcag accgacgaca ccgccatcta      720

ctactgcgcc aagcactact actacggcgg cagctacgcc atggactact ggggccaggg      780

cacaagcgtg accgtgtctg ccctgagcaa cagcatcatg tacttcagcc acttcgtgcc      840

cgtgtttctg cccgccaagc ctaccacaac ccctgcccct agacctccta ccccagcccc      900

tacaatcgcc agccagcctc tgtctctgag gcccgaggct tctagaccag ctgctggcgg      960

agccgtgcac accagaggac tggacaagcc cttctgggtg ctggtggtcg tgggcggagt     1020

gctggcctgt tatagcctgc tcgtgacagt ggccttcatc atcttttggg tgcgcgtgaa     1080

gttcagccgc agcgccgatg cccctgccta tcagcaggga cagaaccagc tgtacaacga     1140

gctgaacctg ggcagacggg aagagtacga cgtgctggac aagagaagag gccgggaccc     1200

tgagatgggc ggcaagccca gaagaaagaa cccccaggaa ggcctgtata acgaactgca     1260

gaaagacaag atggccgagg cctacagcga gatcggcatg aagggcgaac ggcggagagg     1320

caagggccac gatggactgt atcagggcct gagcaccgcc accaaggaca cctatgacgc     1380

cctgcacatg caggctctgc cccctcgctg aaattcatcg acgttaacta ttctag         1436


<210>  30
<211>  1253
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  30
ggtgtcgtga gcggccgctg aactggccac catgtggctg cagtctctgc tgctgctggg       60

caccgtggcc tgtagcatca gcgagatcgt gctgacccag agccctggct ctctggctgt      120

gtctcctggc gagcgcgtga ccatgagctg caagagcagc cagagcgtgt tcttcagcag      180

ctcccagaag aactacctgg cctggtatca gcagatcccc ggccagagcc ccagactgct      240

gatctactgg gccagcacca gagaaagcgg cgtgcccgat agattcaccg gcagcggctc      300

tggcaccgac ttcaccctga caatcagcag cgtgcagccc gaggacctgg ccatctacta      360

ctgccaccag tacctgagca gccggacctt tggccagggc accaagctgg aaatcaagcg      420

gggcagcaca agcggcagcg gaaagcctgg atctggcgag ggctctacca agggccaggt      480

gcagctgcag cagcctggcg ccgaagtcgt gaaacctggc gcctccgtga agatgtcctg      540

caaggccagc ggctacacct tcaccagcta ctacatccac tggatcaagc agacccctgg      600

acagggcctg gaatgggtgg gagtgatcta ccccggcaac gacgacatca gctacaacca      660

gaagttccag ggcaaggcca ccctgaccgc cgacaagtct agcaccaccg cctacatgca      720

gctgtccagc ctgaccagcg aggacagcgc cgtgtactac tgcgccagag aagtgcggct      780

gcggtacttc gatgtgtggg gccagggaac caccgtgacc gtgtctagcg ccctgagcaa      840

cagcatcatg tacttcagcc acttcgtgcc cgtgtttctg cccgccaagc ctaccacaac      900

ccctgcccct agacctccta ccccagcccc tacaatcgcc agccagcctc tgtctctgag      960

gcccgaggct tctagaccag ctgctggcgg agccgtgcac accagaggac tggacaagcc     1020

cttctgggtg ctggtggtcg tgggcggagt gctggcctgt tacagcctgc tcgtgacagt     1080

ggccttcatc atcttttggg tgcgcagcaa gcggtctaga ctgctgcaca gcgactacat     1140

gaacatgacc cccagaaggc caggccccac ccggaagcac tatcagcctt acgcccctcc     1200

cagagacttc gccgcctaca gaagctgaaa ttcatcgacg ttaactattc tag            1253


<210>  31
<211>  1559
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  31
ggtgtcgtga gcggccgctg aactggccac catgtggctg cagtctctgc tgctgctggg       60

caccgtggcc tgcagcatca gcatccagat gacccagacc accagcagcc tgagcgccag      120

cctgggcgat agagtgacca tcagctgcag agccagccag gacatcagca agtacctgaa      180

ctggtatcag cagaaacccg acggcaccgt gaagctgctg atctaccaca ccagcagact      240

gcacagcggc gtgccctcta gattttccgg cagcggctcc ggcaccgact acagcctgac      300

catctccaac ctggaacagg aagatatcgc tacctacttc tgtcagcaag gcaacaccct      360

gccctacacc ttcggcggag gcaccaagct ggaaatcggc agcacaagcg gctctggcaa      420

gcctggatct ggcgagggct ctaccaaggg cctgcaggaa tctggccctg gactggtggc      480

ccctagccag agcctgtctg tgacctgtac cgtgtccggc gtgtccctgc ctgactatgg      540

cgtgtcctgg atcagacagc cccccagaaa gggcctggaa tggctgggag tgatctgggg      600

cagcgagaca acctactaca acagcgccct gaagtcccgg ctgaccatca tcaaggacaa      660

ctccaagagc caggtgttcc tgaagatgaa cagcctgcag accgacgaca ccgccatcta      720

ctactgcgcc aagcactact actacggcgg cagctacgcc atggactact ggggccaggg      780

cacaagcgtg accgtgtctg ccctgagcaa cagcatcatg tacttcagcc acttcgtgcc      840

cgtgtttctg cccgccaagc ctaccacaac ccctgcccct agacctccta ccccagcccc      900

tacaatcgcc agccagcctc tgtctctgag gcccgaggct tctagaccag ctgctggcgg      960

agccgtgcac accagaggac tggacaagcc cttctgggtg ctggtggtcg tgggcggagt     1020

gctggcctgt tatagcctgc tcgtgacagt ggccttcatc atcttttggg tgcgcagcaa     1080

gcggagccgg ctgctgcact ccgactacat gaacatgacc cccagacggc caggccccac     1140

ccggaaacac tatcagcctt acgcccctcc cagagacttc gccgcctacc ggtccagagt     1200

gaagttcagc agatccgccg acgcccctgc ctatcagcag ggacagaacc agctgtacaa     1260

cgagctgaac ctgggcagac gggaagagta cgacgtgctg gacaagagaa gaggccggga     1320

ccctgagatg ggcggcaagc ccagaagaaa gaacccccag gaaggcctgt ataacgaact     1380

gcagaaagac aagatggccg aggcctacag cgagatcggc atgaagggcg aacggcggag     1440

aggcaagggc cacgatggac tgtatcaggg cctgagcacc gccaccaagg acacctatga     1500

cgccctgcac atgcaggctc tgccccctcg ctgaaattca tcgacgttaa ctattctag      1559


<210>  32
<211>  1514
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  32
ggtgtcgtga gcggccgctg aactggccac catgtggctg cagtctctgc tgctgctggg       60

caccgtggcc tgtagcatca gcgagatcgt gctgacccag agccctggct ctctggctgt      120

gtctcctggc gagcgcgtga ccatgagctg caagagcagc cagagcgtgt tcttcagcag      180

ctcccagaag aactacctgg cctggtatca gcagatcccc ggccagagcc ccagactgct      240

gatctactgg gccagcacca gagaaagcgg cgtgcccgat agattcaccg gcagcggctc      300

tggcaccgac ttcaccctga caatcagcag cgtgcagccc gaggacctgg ccatctacta      360

ctgccaccag tacctgagca gccggacctt tggccagggc accaagctgg aaatcaagcg      420

gggcagcaca agcggcagcg gaaagcctgg atctggcgag ggctctacca agggccaggt      480

gcagctgcag cagcctggcg ccgaagtcgt gaaacctggc gcctccgtga agatgtcctg      540

caaggccagc ggctacacct tcaccagcta ctacatccac tggatcaagc agacccctgg      600

acagggcctg gaatgggtgg gagtgatcta ccccggcaac gacgacatca gctacaacca      660

gaagttccag ggcaaggcca ccctgaccgc cgacaagtct agcaccaccg cctacatgca      720

gctgtccagc ctgaccagcg aggacagcgc cgtgtactac tgcgccagag aagtgcggct      780

gcggtacttc gatgtgtggg gccagggaac caccgtgacc gtgtccagca tcgaagtgat      840

gtacccccct ccctacctgg acaacgagaa gtccaacggc accatcatcc acgtgaaggg      900

caagcacctg tgccccagcc ctctgtttcc tggccctagc aagcccttct gggtgctggt      960

ggtcgtgggc ggagtgctgg cctgttacag cctgctcgtg acagtggcct tcatcatctt     1020

ttgggtgcgc agcaagcggt ctagactgct gcacagcgac tacatgaaca tgacccccag     1080

aaggccaggc cccacccgga agcactatca gccttacgcc cctcccagag acttcgccgc     1140

ctaccggtcc agagtgaagt tcagcagaag cgccgacgcc cctgcctatc agcagggcca     1200

gaaccagctg tacaacgagc tgaacctggg cagacgggaa gagtacgacg tgctggacaa     1260

gcggagaggc agggaccctg agatgggcgg caagcccaga cggaagaacc ctcaggaagg     1320

cctgtataac gaactgcaga aagacaagat ggccgaggcc tactccgaga tcggcatgaa     1380

gggcgagcgg agaagaggca agggccacga tggactgtac cagggcctga gcaccgccac     1440

caaggacacc tatgacgccc tgcacatgca ggccctgccc cccagatgaa attcatcgac     1500

gttaactatt ctag                                                       1514


<210>  33
<211>  850
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  33
ggtgtcgtga gcggccgctg aactggccac catggacatg agggtccctg ctcagctcct       60

ggggctcctg ctgctctggc tctcaggtgc cagatgtgag atcgtgctga cccagagccc      120

cggcagcctg gccgtgagcc ccggcaagag ggtgaccatg agctgcaaga gcagccagag      180

cgtgttcttc agcagcagcc agaagaacta cctggcctgg taccagcaga tccccggcca      240

gagccccagg ctgctgatct actgggccag caccagggag agcggcgtgc ccgacaggtt      300

caccggcagc ggcagcggca gcggcaccga cttcaccctg accatcagca gcgtgcagcc      360

cgaggacctg gccatctact actgccacca gtacctgagc agcaggacct tcggccaggg      420

caccaagctg gagatcaaga ggggcagcac cagcggcagc ggcaagcccg gcagcggcga      480

gggcagcacc aagggccagg tgcagctgca gcagcccggc gccgaggtgg tgaagcccgg      540

cgccagcgtg aagatgagct gcaaggccag cggctacacc ttcaccagct actacatcca      600

ctggatcaag cagacccccg gccagggcct ggagtgggtg ggcgtgatct accccggcaa      660

cgacgacatc agctacaacc agaagttcca gggcaaggcc accctgaccg ccgacaagag      720

cagcaccacc gcctacatgc agctgagcag cctgaccagc gaggacagcg ccgtgtacta      780

ctgcgccagg gaggtgaggc tgaggtactt cgacgtgtgg ggccagggca ccaccgtgac      840

cgtgagcagc                                                             850


<210>  34
<211>  695
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  34
gcggccgcaa ttgaagttat gtatcctcct ccttacctag acaatgagaa gagcaatgga       60

accattatcc atgtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      120

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      180

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      240

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc      300

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc      360

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag      420

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga      480

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc      540

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac      600

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc      660

cctcgctaac gcccctctcc ctcccccccc cctaa                                 695


<210>  35
<211>  641
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  35
gcggccgcac tatcaatttt tgatcctcct ccttttaaag taactcttac aggaggatat       60

ttgcatattt atgaatcaca actttgttgc cagctgaagt tctggttacc cataggatgt      120

gcagcctttg ttgtagtctg cattttggga tgcatactta tttgttggct tacaaaaaag      180

aagtattcat ccagtgtgca cgaccctaac ggtgaataca tgttcatgag agcagtgaac      240

acagccaaaa aatctagact cacagatgtg accctaagag tgaagttcag caggagcgca      300

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga      360

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag      420

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg      480

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc      540

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc      600

ctgccccctc gctaacgccc ctctccctcc ccccccccta a                          641


<210>  36
<211>  665
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  36
gcggccgcaa ttgaagttat gtatcctcct ccttacctag acaatgagaa gagcaatgga       60

accattatcc atgtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      120

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      180

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      240

tacatgttca tgagagcagt gaacacagcc aaaaaatcta gactcacaga tgtgacccta      300

agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc      360

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      420

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      480

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      540

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      600

tacgacgccc ttcacatgca ggccctgccc cctcgctaac gcccctctcc ctcccccccc      660

cctaa                                                                  665


<210>  37
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  37
ccctcgtttc cccacagggg ccctggctat gg                                     32


<210>  38
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  38
gggagcaaag gggtgtcccc gggaccgata cc                                     32


<210>  39
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  39
ccccacaggg gccctgg                                                      17


<210>  40
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  40
tcaccttctc ccaccgtgtg agtgctggtg ga                                     32


<210>  41
<211>  32
<212>  DNA
<213>  Homo sapiens

<400>  41
agtggaagag ggtggcacac tcacgaccac ct                                     32


<210>  42
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  42
gggcttttct ccccaaacga ggg                                               23


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  43
agggctttgt ggggaaacga gg                                                22


<210>  44
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  44
ccccgcgggg gccctggcta tgg                                               23


<210>  45
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  45
agcgctcgca cggtgggaga agg                                               23


<210>  46
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  46
atcttacctt gtgttccgga ggg                                               23


<210>  47
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Oligonucleotide

<400>  47
gtggtacctg ctggctgagg agg                                               23


