                         SEQUENCE LISTING

<110>  The Wistar Institute of Anatomy and Biology
       Muthumani, Kar
       Abdel-Mohsen, Mohamed
       Somasundaram, Shyam
       Weiner, David B
 
<120>  Monoclonal Antibodies Against Human Siglec-9 and Use Thereof for 
       Immunotherapy

<130>  206193-0040-00WO

<150>  US 63/033,916
<151>  2020-06-03

<150>  US 63/047,123
<151>  2020-07-01

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Heavy Chain CDR1

<400>  1

Ser Tyr Ala Met Ser 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Heavy Chain CDR2

<400>  2

Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Heavy Chain CDR3

<400>  3

Trp Tyr Tyr Gly Ser Ser Arg Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Light Chain CDR1

<400>  4

Thr Leu Ser Ser Gln His Ser Thr Tyr Thr Ile Glu 
1               5                   10          


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Light Chain CDR2

<400>  5

Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp 
1               5                   10      


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Light Chain CDR3

<400>  6

Gly Val Gly Asp Thr Ile Lys Glu Gln Phe Val Tyr Val 
1               5                   10              


<210>  7
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Heavy Chain

<400>  7

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Asp Trp Val Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Ser 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Tyr Tyr Gly Ser Ser Arg Tyr Trp Tyr Phe 
        115                 120                 125             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140     


<210>  8
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Light Chain

<400>  8

Met Ala Trp Thr Pro Leu Phe Phe Phe Phe Val Leu His Cys Ser Gly 
1               5                   10                  15      


Ser Phe Ser Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser 
            20                  25                  30          


Leu Gly Ala Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser 
        35                  40                  45              


Thr Tyr Thr Ile Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys 
    50                  55                  60                  


Tyr Val Met Asp Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly 
65                  70                  75                  80  


Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu 
                85                  90                  95      


Ser Ile Ser Asn Ile Gln Pro Glu Asp Glu Ala Ile Tyr Ile Cys Gly 
            100                 105                 110         


Val Gly Asp Thr Ile Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Val Thr Val Leu 
    130                 


<210>  9
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Heavy Chain CDR1

<400>  9
agctatgcca tgtct                                                        15


<210>  10
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Heavy Chain CDR2

<400>  10
accattagta gtggtggtag ttacacctac tattcagaca gtgtgaaggg g                51


<210>  11
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Heavy Chain CDR3

<400>  11
tggtactacg gtagtagccg ctactggtac ttcgatgtc                              39


<210>  12
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Light Chain CDR1

<400>  12
accttgagta gtcagcacag tacgtacacc attgaa                                 36


<210>  13
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Light Chain CDR2

<400>  13
cttaagaaag atggaagcca cagcacaggt gat                                    33


<210>  14
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Light Chain CDR3

<400>  14
ggtgtgggtg atacaattaa ggaacaattt gtgtatgtt                              39


<210>  15
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Heavy Chain

<400>  15
atgaacttcg ggctcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgatgctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcac tttcagtagc tatgccatgt cttgggttcg ccagactccg      180

gagaagaggc tggactgggt cgcaaccatt agtagtggtg gtagttacac ctactattca      240

gacagtgtga aggggcgatt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

caaatgagca gtctgaggtc tgaggacacg gccatgtatt actgtgcaag atggtactac      360

ggtagtagcc gctactggta cttcgatgtc tggggcgcag ggaccacggt caccgtctcc      420

tca                                                                    423


<210>  16
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, 8A1E9 Light Chain

<400>  16
atggcctgga ctcctctctt cttcttcttt gttcttcatt gctcaggttc tttctcccaa       60

cttgtgctca ctcagtcatc ttcagcctct ttctccctgg gagcctcagc aaaactcacg      120

tgcaccttga gtagtcagca cagtacgtac accattgaat ggtatcagca acagccactc      180

aagcctccta agtatgtgat ggaccttaag aaagatggaa gccacagcac aggtgatggg      240

attcctgatc gcttctctgg atccagctct ggtgctgatc gctaccttag catttccaac      300

atccagcctg aagatgaagc aatatacatc tgtggtgtgg gtgatacaat taaggaacaa      360

tttgtgtatg ttttcggcgg tggaaccaag gtcactgtcc ta                         402


