                         SEQUENCE LISTING

<110>  SanaRx BioTherapeutics, Inc.
       WAGNER, Jeffrey
       NEIER, Steven
       POLISKY, Barry
       MERMELSTEIN, Fred
       NOVINA, Carl
       DISTEL, Robert
 
<120>  ENGINEERED MICROORGANISMS FOR DIAGNOSTIC IMAGING

<130>  SRB-001PC/126517-5001

<150>  63/033,443
<151>  2020-06-02

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  1

Met Val Phe Gln Pro Ile Ser Glu Phe Leu Leu Ile Arg Asn Ala Gly 
1               5                   10                  15      


Met Ser Met Tyr Phe Asn Lys Ile Ile Ser Phe Asn Ile Ile Ser Arg 
            20                  25                  30          


Ile Val Ile Cys Ile Phe Leu Ile Cys Gly Met Phe Met Ala Gly Ala 
        35                  40                  45              


Ser Glu Lys Tyr Asp Ala Asn Ala Pro Gln Gln Val Gln Pro Tyr Ser 
    50                  55                  60                  


Val Ser Ser Ser Ala Phe Glu Asn Leu His Pro Asn Asn Glu Met Glu 
65                  70                  75                  80  


Ser Ser Ile Asn Pro Phe Ser Ala Ser Asp Thr Glu Arg Asn Ala Ala 
                85                  90                  95      


Ile Ile Asp Arg Ala Asn Lys Glu Gln Glu Thr Glu Ala Val Asn Lys 
            100                 105                 110         


Met Ile Ser Thr Gly Ala Arg Leu Ala Ala Ser Gly Arg Ala Ser Asp 
        115                 120                 125             


Val Ala His Ser Met Val Gly Asp Ala Val Asn Gln Glu Ile Lys Gln 
    130                 135                 140                 


Trp Leu Asn Arg Phe Gly Thr Ala Gln Val Asn Leu Asn Phe Asp Lys 
145                 150                 155                 160 


Asn Phe Ser Leu Lys Glu Ser Ser Leu Asp Trp Leu Ala Pro Trp Tyr 
                165                 170                 175     


Asp Ser Ala Ser Phe Leu Phe Phe Ser Gln Leu Gly Ile Arg Asn Lys 
            180                 185                 190         


Asp Ser Arg Asn Thr Leu Asn Leu Gly Val Gly Ile Arg Thr Leu Glu 
        195                 200                 205             


Asn Gly Trp Leu Tyr Gly Leu Asn Thr Phe Tyr Asp Asn Asp Leu Thr 
    210                 215                 220                 


Gly His Asn His Arg Ile Gly Leu Gly Ala Glu Ala Trp Thr Asp Tyr 
225                 230                 235                 240 


Leu Gln Leu Ala Ala Asn Gly Tyr Phe Arg Leu Asn Gly Trp His Ser 
                245                 250                 255     


Ser Arg Asp Phe Ser Asp Tyr Lys Glu Arg Pro Ala Thr Gly Gly Asp 
            260                 265                 270         


Leu Arg Ala Asn Ala Tyr Leu Pro Ala Leu Pro Gln Leu Gly Gly Lys 
        275                 280                 285             


Leu Met Tyr Glu Gln Tyr Thr Gly Glu Arg Val Ala Leu Phe Gly Lys 
    290                 295                 300                 


Asp Asn Leu Gln Arg Asn Pro Tyr Ala Val Thr Ala Gly Ile Asn Tyr 
305                 310                 315                 320 


Thr Pro Val Pro Leu Leu Thr Val Gly Val Asp Gln Arg Met Gly Lys 
                325                 330                 335     


Ser Ser Lys His Glu Thr Gln Trp Asn Leu Gln Met Asn Tyr Arg Leu 
            340                 345                 350         


Gly Glu Ser Phe Gln Ser Gln Leu Ser Pro Ser Ala Val Ala Gly Thr 
        355                 360                 365             


Arg Leu Leu Ala Glu Ser Arg Tyr Asn Leu Val Asp Arg Asn Asn Asn 
    370                 375                 380                 


Ile Val Leu Glu Tyr Gln Lys Gln Gln Val Val Lys Leu Thr Leu Ser 
385                 390                 395                 400 


Pro Ala Thr Ile Ser Gly Leu Pro Gly Gln Val Tyr Gln Val Asn Ala 
                405                 410                 415     


Gln Val Gln Gly Ala Ser Ala Val Arg Glu Ile Val Trp Ser Asp Ala 
            420                 425                 430         


Glu Leu Ile Ala Ala Gly Gly Thr Leu Thr Pro Leu Ser Thr Thr Gln 
        435                 440                 445             


Phe Asn Leu Val Leu Pro Pro Tyr Lys Arg Thr Ala Gln Val Ser Arg 
    450                 455                 460                 


Val Thr Asp Asp Leu Thr Ala Asn Phe Tyr Ser Leu Ser Ala Leu Ala 
465                 470                 475                 480 


Val Asp His Gln Gly Asn Arg Ser Asn Ser Phe Thr Leu Ser Val Thr 
                485                 490                 495     


Val Gln Gln Pro Gln Leu Thr Leu Thr Ala Ala Val Ile Gly Asp Gly 
            500                 505                 510         


Ala Pro Ala Asn Gly Lys Thr Ala Ile Thr Val Glu Phe Thr Val Ala 
        515                 520                 525             


Asp Phe Glu Gly Lys Pro Leu Ala Gly Gln Glu Val Val Ile Thr Thr 
    530                 535                 540                 


Asn Asn Gly Ala Leu Pro Asn Lys Ile Thr Glu Lys Thr Asp Ala Asn 
545                 550                 555                 560 


Gly Val Ala Arg Ile Ala Leu Thr Asn Thr Thr Asp Gly Val Thr Val 
                565                 570                 575     


Val Thr Ala Glu Val Glu Gly Gln Arg Gln Ser Val Asp Thr His Phe 
            580                 585                 590         


Val Lys Gly Thr Ile Ala Ala Asp Lys Ser Thr Leu Ala Ala Val Pro 
        595                 600                 605             


Thr Ser Ile Ile Ala Asp Gly Leu Met Ala Ser Thr Ile Thr Leu Glu 
    610                 615                 620                 


Leu Lys Asp Thr Tyr Gly Asp Pro Gln Ala Gly Ala Asn Val Ala Phe 
625                 630                 635                 640 


Asp Thr Thr Leu Gly Asn Met Gly Val Ile Thr Asp His Asn Asp Gly 
                645                 650                 655     


Thr Tyr Ser Ala Pro Leu Thr Ser Thr Thr Leu Gly Val Ala Thr Val 
            660                 665                 670         


Thr Val Lys Val Asp Gly Ala Ala Phe Ser Val Pro Ser Val Thr Val 
        675                 680                 685             


Asn Phe Thr Ala Asp Pro Ile Pro Asp Ala Gly Arg Ser Ser Phe Thr 
    690                 695                 700                 


Val Ser Thr Pro Asp Ile Leu Ala Asp Gly Thr Met Ser Ser Thr Leu 
705                 710                 715                 720 


Ser Phe Val Pro Val Asp Lys Asn Gly His Phe Ile Ser Gly Met Gln 
                725                 730                 735     


Gly Leu Ser Phe Thr Gln Asn Gly Val Pro Val Ser Ile Ser Pro Ile 
            740                 745                 750         


Thr Glu Gln Pro Asp Ser Tyr Thr Ala Thr Val Val Gly Asn Thr Ala 
        755                 760                 765             


Gly Asp Val Thr Ile Thr Pro Gln Val Asp Thr Leu Ile Leu Ser Thr 
    770                 775                 780                 


Leu Gln Lys Lys Ile Ser Leu Phe Pro Val Pro Thr Leu Thr Gly Ile 
785                 790                 795                 800 


Leu Val Asn Gly Gln Asn Phe Ala Thr Asp Lys Gly Phe Pro Lys Thr 
                805                 810                 815     


Ile Phe Lys Asn Ala Thr Phe Gln Leu Gln Met Asp Asn Asp Val Ala 
            820                 825                 830         


Asn Asn Thr Gln Tyr Glu Trp Ser Ser Ser Phe Thr Pro Asn Val Ser 
        835                 840                 845             


Val Asn Asp Gln Gly Gln Val Thr Ile Thr Tyr Gln Thr Tyr Ser Glu 
    850                 855                 860                 


Val Ala Val Thr Ala Lys Ser Lys Lys Phe Pro Ser Tyr Ser Val Ser 
865                 870                 875                 880 


Tyr Arg Phe Tyr Pro Asn Arg Trp Ile Tyr Asp Gly Gly Thr Ser Leu 
                885                 890                 895     


Val Ser Ser Leu Glu Ala Ser Arg Gln Cys Gln Gly Ser Asp Met Ser 
            900                 905                 910         


Ala Val Leu Glu Ser Ser Arg Ala Thr Asn Gly Thr Arg Ala Pro Asp 
        915                 920                 925             


Gly Thr Leu Trp Gly Glu Trp Gly Ser Leu Thr Ala Tyr Ser Ser Asp 
    930                 935                 940                 


Trp Gln Ser Gly Glu Tyr Trp Val Lys Lys Thr Ser Thr Asp Phe Glu 
945                 950                 955                 960 


Thr Met Asn Met Asp Thr Gly Ala Leu Val Gln Gly Pro Ala Tyr Leu 
                965                 970                 975     


Ala Phe Pro Leu Cys Ala Leu Ala Ile 
            980                 985 


<210>  2
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  2

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Ile Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe His Lys 
            20                  25                  30          


Glu Asp Leu Ile Ser Ser Met Ala Pro Pro Thr Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Ile Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val 
        435                 440                 445             


Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe 
    450                 455                 460                 


Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr 
465                 470                 475                 480 


Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile 
                485                 490                 495     


Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp 
            500                 505                 510         


Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Ser Val Asp Asn Pro Ile 
        515                 520                 525             


Glu 
    


<210>  3
<211>  658
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  3

Met Ile Thr His Gly Cys Tyr Thr Arg Thr Arg His Lys His Lys Leu 
1               5                   10                  15      


Lys Lys Thr Leu Ile Met Leu Ser Ala Gly Leu Gly Leu Phe Phe Tyr 
            20                  25                  30          


Val Asn Gln Asn Ser Phe Ala Asn Gly Glu Asn Tyr Phe Lys Leu Gly 
        35                  40                  45              


Ser Asp Ser Lys Leu Leu Thr His Asp Ser Tyr Gln Asn Arg Leu Phe 
    50                  55                  60                  


Tyr Thr Leu Lys Thr Gly Glu Thr Val Ala Asp Leu Ser Lys Ser Gln 
65                  70                  75                  80  


Asp Ile Asn Leu Ser Thr Ile Trp Ser Leu Asn Lys His Leu Tyr Ser 
                85                  90                  95      


Ser Glu Ser Glu Met Met Lys Ala Ala Pro Gly Gln Gln Ile Ile Leu 
            100                 105                 110         


Pro Leu Lys Lys Leu Pro Phe Glu Tyr Ser Ala Leu Pro Leu Leu Gly 
        115                 120                 125             


Ser Ala Pro Leu Val Ala Ala Gly Gly Val Ala Gly His Thr Asn Lys 
    130                 135                 140                 


Leu Thr Lys Met Ser Pro Asp Val Thr Lys Ser Asn Met Thr Asp Asp 
145                 150                 155                 160 


Lys Ala Leu Asn Tyr Ala Ala Gln Gln Ala Ala Ser Leu Gly Ser Gln 
                165                 170                 175     


Leu Gln Ser Arg Ser Leu Asn Gly Asp Tyr Ala Lys Asp Thr Ala Leu 
            180                 185                 190         


Gly Ile Ala Gly Asn Gln Ala Ser Ser Gln Leu Gln Ala Trp Leu Gln 
        195                 200                 205             


His Tyr Gly Thr Ala Glu Val Asn Leu Gln Ser Gly Asn Asn Phe Asp 
    210                 215                 220                 


Gly Ser Ser Leu Asp Phe Leu Leu Pro Phe Tyr Asp Ser Glu Lys Met 
225                 230                 235                 240 


Leu Ala Phe Gly Gln Val Gly Ala Arg Tyr Ile Asp Ser Arg Phe Thr 
                245                 250                 255     


Ala Asn Leu Gly Ala Gly Gln Arg Phe Phe Leu Pro Ala Asn Met Leu 
            260                 265                 270         


Gly Tyr Asn Val Phe Ile Asp Gln Asp Phe Ser Gly Asp Asn Thr Arg 
        275                 280                 285             


Leu Gly Ile Gly Gly Glu Tyr Trp Arg Asp Tyr Phe Lys Ser Ser Val 
    290                 295                 300                 


Asn Gly Tyr Phe Arg Met Ser Gly Trp His Glu Ser Tyr Asn Lys Lys 
305                 310                 315                 320 


Asp Tyr Asp Glu Arg Pro Ala Asn Gly Phe Asp Ile Arg Phe Asn Gly 
                325                 330                 335     


Tyr Leu Pro Ser Tyr Pro Ala Leu Gly Ala Lys Leu Ile Tyr Glu Gln 
            340                 345                 350         


Tyr Tyr Gly Asp Asn Val Ala Leu Phe Asn Ser Asp Lys Leu Gln Ser 
        355                 360                 365             


Asn Pro Gly Ala Ala Thr Val Gly Val Asn Tyr Thr Pro Ile Pro Leu 
    370                 375                 380                 


Val Thr Met Gly Ile Asp Tyr Arg His Gly Thr Gly Asn Glu Asn Asp 
385                 390                 395                 400 


Leu Leu Tyr Ser Met Gln Phe Arg Tyr Gln Phe Asp Lys Ser Trp Ser 
                405                 410                 415     


Gln Gln Ile Glu Pro Gln Tyr Val Asn Glu Leu Arg Thr Leu Ser Gly 
            420                 425                 430         


Ser Arg Tyr Asp Leu Val Gln Arg Asn Asn Asn Ile Ile Leu Glu Tyr 
        435                 440                 445             


Lys Lys Gln Asp Ile Leu Ser Leu Asn Ile Pro His Asp Ile Asn Gly 
    450                 455                 460                 


Thr Glu His Ser Thr Gln Lys Ile Gln Leu Ile Val Lys Ser Lys Tyr 
465                 470                 475                 480 


Gly Leu Asp Arg Ile Val Trp Asp Asp Ser Ala Leu Arg Ser Gln Gly 
                485                 490                 495     


Gly Gln Ile Gln His Ser Gly Ser Gln Ser Ala Gln Asp Tyr Gln Ala 
            500                 505                 510         


Ile Leu Pro Ala Tyr Val Gln Gly Gly Ser Asn Ile Tyr Lys Val Thr 
        515                 520                 525             


Ala Arg Ala Tyr Asp Arg Asn Gly Asn Ser Ser Asn Asn Val Gln Leu 
    530                 535                 540                 


Thr Ile Thr Val Leu Ser Asn Gly Gln Val Val Asp Gln Val Gly Val 
545                 550                 555                 560 


Thr Asp Phe Thr Ala Asp Lys Thr Ser Ala Lys Ala Asp Asn Ala Asp 
                565                 570                 575     


Thr Ile Thr Tyr Thr Ala Thr Val Lys Lys Asn Gly Val Ala Gln Ala 
            580                 585                 590         


Asn Val Pro Val Ser Phe Asn Ile Val Ser Gly Thr Ala Thr Leu Gly 
        595                 600                 605             


Ala Asn Ser Ala Lys Thr Asp Ala Asn Gly Lys Ala Thr Val Thr Leu 
    610                 615                 620                 


Lys Ser Ser Thr Pro Gly Gln Val Val Val Ser Ala Lys Thr Ala Glu 
625                 630                 635                 640 


Met Thr Ser Ala Leu Asn Ala Ser Ala Val Ile Phe Phe Asp Gly Ala 
                645                 650                 655     


Thr Arg 
        


<210>  4
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  4

Met Ile Thr His Gly Cys Tyr Thr Arg Thr Arg His Lys His Lys Leu 
1               5                   10                  15      


Lys Lys Thr Leu Ile Met Leu Ser Ala Gly Leu Gly Leu Phe Phe Tyr 
            20                  25                  30          


Val Asn Gln Asn Ser Phe Ala Asn Gly Glu Asn Tyr Phe Lys Leu Gly 
        35                  40                  45              


Ser Asp Ser Lys Leu Leu Thr His Asp Ser Tyr Gln Asn Arg Leu Phe 
    50                  55                  60                  


Tyr Thr Leu Lys Thr Gly Glu Thr Val Ala Asp Leu Ser Lys Ser Gln 
65                  70                  75                  80  


Asp Ile Asn Leu Ser Thr Ile Trp Ser Leu Asn Lys His Leu Tyr Ser 
                85                  90                  95      


Ser Glu Ser Glu Met Met Lys Ala Ala Pro Gly Gln Gln Ile Ile Leu 
            100                 105                 110         


Pro Leu Lys Lys Leu Pro Phe Glu Tyr Ser Ala Leu Pro Leu Leu Gly 
        115                 120                 125             


Ser Ala Pro Leu Val Ala Ala Gly Gly Val Ala Gly His Thr Asn Lys 
    130                 135                 140                 


Leu Thr Lys Met Ser Pro Asp Val Thr Lys Ser Asn Met Thr Asp Asp 
145                 150                 155                 160 


Lys Ala Leu Asn Tyr Ala Ala Gln Gln Ala Ala Ser Leu Gly Ser Gln 
                165                 170                 175     


Leu Gln Ser Arg Ser Leu Asn Gly Asp Tyr Ala Lys Asp Thr Ala Leu 
            180                 185                 190         


Gly Ile Ala Gly Asn Gln Ala Ser Ser Gln Leu Gln Ala Trp Leu Gln 
        195                 200                 205             


His Tyr Gly Thr Ala Glu Val Asn Leu Gln Ser Gly Asn Asn Phe Asp 
    210                 215                 220                 


Gly Ser Ser Leu Asp Phe Leu Leu Pro Phe Tyr Asp Ser Glu Lys Met 
225                 230                 235                 240 


Leu Ala Phe Gly Gln Val Gly Ala Arg Tyr Ile Asp Ser Arg Phe Thr 
                245                 250                 255     


Ala Asn Leu Gly Ala Gly Gln Arg Phe Phe Leu Pro Ala Asn Met Leu 
            260                 265                 270         


Gly Tyr Asn Val Phe Ile Asp Gln Asp Phe Ser Gly Asp Asn Thr Arg 
        275                 280                 285             


Leu Gly Ile Gly Gly Glu Tyr Trp Arg Asp Tyr Phe Lys Ser Ser Val 
    290                 295                 300                 


Asn Gly Tyr Phe Arg Met Ser Gly Trp His Glu Ser Tyr Asn Lys Lys 
305                 310                 315                 320 


Asp Tyr Asp Glu Arg Pro Ala Asn Gly Phe Asp Ile Arg Phe Asn Gly 
                325                 330                 335     


Tyr Leu Pro Ser Tyr Pro Ala Leu Gly Ala Lys Leu Ile Tyr Glu Gln 
            340                 345                 350         


Tyr Tyr Gly Asp Asn Val Ala Leu Phe Asn Ser Asp Lys Leu Gln Ser 
        355                 360                 365             


Asn Pro Gly Ala Ala Thr Val Gly Val Asn Tyr Thr Pro Ile Pro Leu 
    370                 375                 380                 


Val Thr Met Gly Ile Asp Tyr Arg His Gly Thr Gly Asn Glu Asn Asp 
385                 390                 395                 400 


Leu Leu Tyr Ser Met Gln Phe Arg Tyr Gln Phe Asp Lys Ser Trp Ser 
                405                 410                 415     


Gln Gln Ile Glu Pro Gln Tyr Val Asn Glu Leu Arg Thr Leu Ser Gly 
            420                 425                 430         


Ser Arg Tyr Asp Leu Val Gln Arg Asn Asn Asn Ile Ile Leu Glu Tyr 
        435                 440                 445             


Lys Lys Gln Asp Ile Leu Ser Leu Asn Ile Pro His Asp Ile Asn Gly 
    450                 455                 460                 


Thr Glu His Ser Thr Gln Lys Ile Gln Leu Ile Val Lys Ser Lys Tyr 
465                 470                 475                 480 


Gly Leu Asp Arg Ile Val Trp Asp Asp Ser Ala Leu Arg Ser Gln Gly 
                485                 490                 495     


Gly Gln Ile Gln His Ser Gly Ser Gln Ser Ala Gln Asp Tyr Gln Ala 
            500                 505                 510         


Ile Leu Pro Ala Tyr Val Gln Gly Gly Ser Asn Ile Tyr Lys Val Thr 
        515                 520                 525             


Ala Arg Ala Tyr Asp Arg Asn Gly Asn Ser Ser Asn Asn Val Gln Leu 
    530                 535                 540                 


Thr Ile Thr Val Leu Ser Asn Gly Gln Val Val Asp Gln Val Gly Val 
545                 550                 555                 560 


Thr Asp Phe Thr Ala Asp Lys Thr Ser Ala Lys Ala Asp Asn Ala Asp 
                565                 570                 575     


Thr Ile Thr Tyr Thr Ala Thr Val Lys Lys Asn Gly Val Ala Gln Ala 
            580                 585                 590         


Asn Val Pro Val Ser Phe Asn Ile Val Ser Gly Thr Ala Thr Leu Gly 
        595                 600                 605             


Ala Asn Ser Ala Lys Thr Asp Ala Asn Gly Lys Ala Thr Val Thr Leu 
    610                 615                 620                 


Lys Ser Ser Thr Pro Gly Gln Val Val Val Ser Ala Lys Thr Ala Glu 
625                 630                 635                 640 


Met Thr Ser Ala Leu Asn Ala Ser Ala Val Ile Phe Phe Asp Gly Ala 
                645                 650                 655     


Thr Arg Val Pro Thr Leu Thr Gly Ile Leu Val Asn Gly Gln Asn Phe 
            660                 665                 670         


Ala Thr Asp Lys Gly Phe Pro Lys Thr Ile Phe Lys Asn Ala Thr Phe 
        675                 680                 685             


Gln Leu Gln Met Asp Asn Asp Val Ala Asn Asn Thr Gln Tyr Glu Trp 
    690                 695                 700                 


Ser Ser Ser Phe Thr Pro Asn Val Ser Val Asn Asp Gln Gly Gln Val 
705                 710                 715                 720 


Thr Ile Thr Tyr Gln Thr Tyr Ser Glu Val Ala Val Thr Ala Lys Ser 
                725                 730                 735     


Lys Lys Phe Pro Ser Tyr Ser Val Ser Tyr Arg Phe Tyr Pro Asn Arg 
            740                 745                 750         


Trp Ile Tyr Asp Gly Gly Thr Ser Leu Val Ser Ser Leu Glu Ala Ser 
        755                 760                 765             


Arg Gln Cys Gln Gly Ser Asp Met Ser Ala Val Leu Glu Ser Ser Arg 
    770                 775                 780                 


Ala Thr Asn Gly Thr Arg Ala Pro Asp Gly Thr Leu Trp Gly Glu Trp 
785                 790                 795                 800 


Gly Ser Leu Thr Ala Tyr Ser Ser Asp Trp Gln Ser Gly Glu Tyr Trp 
                805                 810                 815     


Val Lys Lys Thr Ser Thr Asp Phe Glu Thr Met Asn Met Asp Thr Gly 
            820                 825                 830         


Ala Leu Val Gln Gly Pro Ala Tyr Leu Ala Phe Pro Leu Cys Ala Leu 
        835                 840                 845             


Ala Ile 
    850 


<210>  5
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  5

Met Ala Arg Lys Val Asp Leu Thr Ser Cys Asp Arg Glu Pro Ile His 
1               5                   10                  15      


Ile Pro Gly Ser Ile Gln Pro Cys Gly Cys Leu Leu Ala Cys Asp Ala 
            20                  25                  30          


Gln Ala Val Arg Ile Thr Arg Ile Thr Glu Asn Ala Gly Ala Phe Phe 
        35                  40                  45              


Gly Arg Glu Thr Pro Arg Val Gly Glu Leu Leu Ala Asp Tyr Phe Gly 
    50                  55                  60                  


Glu Thr Glu Ala His Ala Leu Arg Asn Ala Leu Ala Gln Ser Ser Asp 
65                  70                  75                  80  


Pro Lys Arg Pro Ala Leu Ile Phe Gly Trp Arg Asp Gly Leu Thr Gly 
                85                  90                  95      


Arg Thr Phe Asp Ile Ser Leu His Arg His Asp Gly Thr Ser Ile Ile 
            100                 105                 110         


Glu Phe Glu Pro Ala Ala Ala Glu Gln Ala Asp Asn Pro Leu Arg Leu 
        115                 120                 125             


Thr Arg Gln Ile Ile Ala Arg Thr Lys Glu Leu Lys Ser Leu Glu Glu 
    130                 135                 140                 


Met Ala Ala Arg Val Pro Arg Tyr Leu Gln Ala Met Leu Gly Tyr His 
145                 150                 155                 160 


Arg Val Met Leu Tyr Arg Phe Ala Asp Asp Gly Ser Gly Met Val Ile 
                165                 170                 175     


Gly Glu Ala Lys Arg Ser Asp Leu Glu Ser Phe Leu Gly Gln His Phe 
            180                 185                 190         


Pro Ala Ser Leu Val Pro Gln Gln Ala Arg Leu Leu Tyr Leu Lys Asn 
        195                 200                 205             


Ala Ile Arg Val Val Ser Asp Ser Arg Gly Ile Ser Ser Arg Ile Val 
    210                 215                 220                 


Pro Glu His Asp Ala Ser Gly Ala Ala Leu Asp Leu Ser Phe Ala His 
225                 230                 235                 240 


Leu Arg Ser Ile Ser Pro Cys His Leu Glu Phe Leu Arg Asn Met Gly 
                245                 250                 255     


Val Ser Ala Ser Met Ser Leu Ser Ile Ile Ile Asp Gly Thr Leu Trp 
            260                 265                 270         


Gly Leu Ile Ile Cys His His Tyr Glu Pro Arg Ala Val Pro Met Ala 
        275                 280                 285             


Gln Arg Val Ala Ala Glu Met Phe Ala Asp Phe Leu Ser Leu His Phe 
    290                 295                 300                 


Thr Ala Ala His His Gln Arg 
305                 310     


<210>  6
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  6

Met Asp Ala Ser Ala Phe His Lys Glu Asp Leu Ile Ser Ser Met Ala 
1               5                   10                  15      


Pro Pro Thr Ser Pro Pro Ala Ser Pro Lys Thr Pro Ile Glu Lys Lys 
            20                  25                  30          


His Ala Asp Glu Ile Asp Lys Tyr Ile Gln Gly Leu Asp Tyr Asn Lys 
        35                  40                  45              


Asn Asn Val Leu Val Tyr His Gly Asp Ala Val Thr Asn Val Pro Pro 
    50                  55                  60                  


Arg Lys Gly Tyr Lys Asp Gly Asn Glu Tyr Ile Val Val Glu Lys Lys 
65                  70                  75                  80  


Lys Lys Ser Ile Asn Gln Asn Asn Ala Asp Ile Gln Val Val Asn Ala 
                85                  90                  95      


Ile Ser Ser Leu Thr Tyr Pro Gly Ala Leu Val Lys Ala Asn Ser Glu 
            100                 105                 110         


Leu Val Glu Asn Gln Pro Asp Val Leu Pro Val Lys Arg Asp Ser Leu 
        115                 120                 125             


Thr Leu Ser Ile Asp Leu Pro Gly Met Thr Asn Gln Asp Asn Lys Ile 
    130                 135                 140                 


Val Val Lys Asn Ala Thr Lys Ser Asn Val Asn Asn Ala Val Asn Thr 
145                 150                 155                 160 


Leu Val Glu Arg Trp Asn Glu Lys Tyr Ala Gln Ala Tyr Pro Asn Val 
                165                 170                 175     


Ser Ala Lys Ile Asp Tyr Asp Asp Glu Met Ala Tyr Ser Glu Ser Gln 
            180                 185                 190         


Leu Ile Ala Lys Phe Gly Thr Ala Phe Lys Ala Val Asn Asn Ser Leu 
        195                 200                 205             


Asn Val Asn Phe Gly Ala Ile Ser Glu Gly Lys Met Gln Glu Glu Val 
    210                 215                 220                 


Ile Ser Phe Lys Gln Ile Tyr Tyr Asn Val Asn Val Asn Glu Pro Thr 
225                 230                 235                 240 


Arg Pro Ser Arg Phe Phe Gly Lys Ala Val Thr Lys Glu Gln Leu Gln 
                245                 250                 255     


Ala Leu Gly Val Asn Ala Glu Asn Pro Pro Ala Tyr Ile Ser Ser Val 
            260                 265                 270         


Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Ser Thr Asn Ser His Ser 
        275                 280                 285             


Thr Lys Val Lys Ala Ala Phe Asp Ala Ala Val Ser Gly Lys Ser Val 
    290                 295                 300                 


Ser Gly Asp Val Glu Leu Thr Asn Ile Ile Lys Asn Ser Ser Phe Lys 
305                 310                 315                 320 


Ala Val Ile Tyr Gly Gly Ser Ala Lys Asp Glu Val Gln Ile Ile Asp 
                325                 330                 335     


Gly Asn Leu Gly Asp Leu Arg Asp Ile Leu Lys Lys Gly Ala Thr Phe 
            340                 345                 350         


Asn Arg Glu Thr Pro Gly Val Pro Ile Ala Tyr Thr Thr Asn Phe Leu 
        355                 360                 365             


Lys Asp Asn Glu Leu Ala Val Ile Lys Asn Asn Ser Glu Tyr Ile Glu 
    370                 375                 380                 


Thr Thr Ser Lys Ala Tyr Thr Asp Gly Lys Ile Asn Ile Asp His Ser 
385                 390                 395                 400 


Gly Gly Tyr Val Ala Gln Phe Asn Ile Ser Trp Asp Glu Ile Asn Tyr 
                405                 410                 415     


Asp Pro Glu Gly Asn Glu Ile Val Gln His Lys Asn Trp Ser Glu Asn 
            420                 425                 430         


Asn Lys Ser Lys Leu Ala His Phe Thr Ser Ser Ile Tyr Leu Pro Gly 
        435                 440                 445             


Asn Ala Arg Asn Ile Asn Val Tyr Ala Lys Glu Cys Thr Gly Leu Ala 
    450                 455                 460                 


Trp Glu Trp Trp Arg Thr Val Ile Asp Asp Arg Asn Leu Pro Leu Val 
465                 470                 475                 480 


Lys Asn Arg Asn Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Lys Tyr 
                485                 490                 495     


Ser Asn Ser Val Asp Asn Pro Ile Glu 
            500                 505 


