                         SEQUENCE LISTING

<110>  Kenjockety Biotechnology, LLC
       Arathoon, William Robert
       Briante, Raffaella
       Mohanty, Suchismita
       Ponath, Paul David
       Theolis, Richard  Jr.
       Zhai, Qianting
       Zhang, Pingping
 
<120>  ANTI-ABCG2 ANTIBODIES AND USES THEREOF

<130>  KNJY-004WO

<150>  63/034,806
<151>  2020-06-04

<160>  420   

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly 
1               5                   10          


<210>  2
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Lys Pro Lys Ala Asp Ala Phe 
1               5               


<210>  3
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Leu Thr Thr Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser 
1               5                   10                  15      


Ile Pro Arg Tyr Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly 
            20                  25                  30          


Gln Asn Phe Cys Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn 
        35                  40                  45              


Tyr Ala Thr Cys Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp 
    50                  55                  60                  


Leu Ser Pro Trp Gly Leu Trp Lys Asn His 
65                  70                  


<210>  4
<211>  119
<212>  PRT
<213>  Unknown

<220>
<223>  anti-ABCG2 antibody

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Phe Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Asn Phe Asp Gly Gly Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Gly Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Arg Ser Val Thr Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Phe Tyr Gly Ala Lys Gly Thr Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  107
<212>  PRT
<213>  Unknown

<220>
<223>  anti-ABCG2 antibody

<400>  5

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Phe Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Lys Ala Ser Gly Tyr Ile Leu Asn Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Phe Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Ser Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Gly Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  6
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  anti-ABCG2 antibody

<400>  6

Gly Phe Ser Ile Thr Ser Asp Tyr Ala Trp 
1               5                   10  


<210>  7
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  anti-ABCG2 antibody

<400>  7

Gly Tyr Ile Asn Phe Asp Gly Gly Thr Thr Tyr Asn Pro Ser Leu Arg 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  anti-ABCG2 antibody

<400>  8

Ala Thr Phe Tyr Gly Ala Lys Gly Thr Leu Asp Tyr 
1               5                   10          


<210>  9
<211>  11
<212>  PRT
<213>  Unknown

<220>
<223>  anti-ABCG2 antibody

<400>  9

Lys Ala Ser Gly Tyr Ile Leu Asn Arg Leu Ala 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  anti-ABCG2 antibody

<400>  10

Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  anti-ABCG2 antibody

<400>  11

Gln Gln Tyr Trp Ser Thr Pro Trp Thr 
1               5                   


<210>  12
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Arg Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Tyr Gly Asn Phe Leu Tyr Ala Met Asp Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  13
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  13

Glu Val Met Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Thr Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Gly Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Asp Gly Asn Tyr Glu Gly Val Leu Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  14
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  14

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Thr Phe Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Val Pro Ser Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Phe Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Val Tyr Gly Tyr Asp Val Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  15

Gln Gly Gln Met His Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Asn Ser Gly 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Arg Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Ile Ser Asn Phe Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Ala Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Ser Gly Ala Arg Lys Thr Leu Asp Phe Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  16
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Val Gln Leu Gln Gln Ser Gly Ala Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Val His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Arg Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Pro Pro Leu Trp Val Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  17
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  17

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Arg Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Pro Pro Leu Trp Val Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  18
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  18

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Gln Gly Asn Thr Arg Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Pro Pro Leu Trp Val Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  19
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  19

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ser Gly Asn Thr Arg Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Met Thr Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Pro Pro Leu Trp Val Gly Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  20
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  20

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Val Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Gly Tyr 
65                  70                  75                  80  


Met Gln Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ile Gly Leu Arg Tyr Phe Asp Asn Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  21
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  21

Glu Ile Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Val Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ala Ser Thr Gly Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ile Gly Leu Arg Tyr Phe Asp Asn Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  22
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  22

Glu Val Arg Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Arg Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Tyr Gly Asn Phe Leu Tyr Ala Met Asp Asn Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  23
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  23

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Thr Phe Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser Pro Glu Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Lys Ile Val Pro Ser Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Phe Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Thr Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Lys Val Tyr Gly Tyr Asp Val Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120         


<210>  24
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  24

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Arg Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Tyr Gly Asn Phe Leu Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  25
<211>  118
<212>  PRT
<213>  Rattus norvegicus

<400>  25

Glu Val Lys Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Thr Ile Thr Ser Gly 
            20                  25                  30          


Tyr Asp Trp Ser Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Trp Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Gly Tyr Asn Pro Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  26
<211>  118
<212>  PRT
<213>  Rattus norvegicus

<400>  26

Glu Val Gln Leu Glu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Thr Ile Thr Ser Gly 
            20                  25                  30          


Tyr Asp Trp Thr Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Phe Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Thr Arg Gly Tyr Asn Pro Phe Ala Tyr Trp Gly Gln Gly Ala 
            100                 105                 110         


Ser Val Ser Ser Ala Ser 
        115             


<210>  27
<211>  118
<212>  PRT
<213>  Rattus norvegicus

<400>  27

Glu Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Thr Ile Thr Ser Gly 
            20                  25                  30          


Tyr Asp Trp Thr Trp Leu Arg Lys Phe Pro Gly Asn Lys Met Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Phe Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Ile Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Arg Gly Tyr Asn Pro Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  28
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  28

Ser Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 
                85                  90                  95      


Arg Asp Thr Tyr Tyr Gly Tyr Asn Gln Ile Pro Phe Val Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  29
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  29

Ser Val Gln Trp Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Gly Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 
                85                  90                  95      


Arg Ala Gly Tyr Tyr Gly Tyr Asn Pro Ile Trp Phe Thr Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  30
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Met Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 
                85                  90                  95      


Arg Val Gly Tyr Tyr Gly Tyr Asn Pro Ile Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  31
<211>  117
<212>  PRT
<213>  Rattus norvegicus

<400>  31

Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Thr Ile Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Thr Ser Val Gly Gly Ala Thr His Tyr Asn Ser Pro Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Gly Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Met Tyr Phe Cys Val 
                85                  90                  95      


Arg Ser Gly Tyr Tyr Ser Thr Tyr Met Asn Trp Gly Arg Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  32
<211>  117
<212>  PRT
<213>  Rattus norvegicus

<400>  32

Ser Val Gln Leu Met Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Ser Tyr 
            20                  25                  30          


Asn Val Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ser Gly Tyr Tyr Ser Ser Tyr Met Asn Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  33
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Thr Gly Gly Gly Thr Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Leu Ala Ala Pro Trp Asn Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Ser Ser Ala 
        115                 120     


<210>  34
<211>  118
<212>  PRT
<213>  Rattus norvegicus

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Thr Ile Thr Ser Gly 
            20                  25                  30          


Tyr Asp Trp Thr Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Phe Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Thr Arg Gly Tyr Asn Pro Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  35
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  35

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Arg Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Ala Gly Ser Thr Tyr Tyr Arg Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Val Ala Ala Pro Trp Asn Tyr Val Met Asp Gly Trp Gly Gln 
            100                 105                 110         


Gly Ala Ser Val Thr Val Ser Ser 
        115                 120 


<210>  36
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  36

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Ser His Gly Gly Asp Thr Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Ala Ala Pro Trp Asn Tyr Val Met Asp Gly Trp Gly Leu 
            100                 105                 110         


Gly Ala Ser Val Thr Val Ser Ser 
        115                 120 


<210>  37
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  37

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Ser His Gly Gly Asp Thr Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Ala Ala Pro Trp Asn Tyr Val Met Asp Gly Trp Gly Leu 
            100                 105                 110         


Gly Ala Ser Val Thr Val Ser Ser 
        115                 120 


<210>  38
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  38

Gln Ile Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Asn 
            20                  25                  30          


Tyr Ile Ser Trp Leu Arg Gln Lys Pro Arg Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ser Gly Thr Gly Gly Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Ile Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Val Gly Leu Arg Tyr Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  39
<211>  123
<212>  PRT
<213>  Rattus norvegicus

<400>  39

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Tyr Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Thr Gly Gly His Ser Thr Tyr Tyr Arg Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Val Ser Gly Asp Tyr Ser Ser Tyr Ile Tyr Val Met Asp Ala 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  40
<211>  118
<212>  PRT
<213>  Rattus norvegicus

<400>  40

Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Thr Ile Thr Ser Gly 
            20                  25                  30          


Tyr Asp Trp Thr Trp Ile Arg Lys Phe Pro Gly Asn Lys Met Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Phe Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Thr Arg Gly Tyr Asn Pro Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  41
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  41

Glu Val Lys Leu Glu Glu Ser Gly Gly Ala Phe Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Asp Ser Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Leu Gly Val Pro Met Gly Met Ile Asn Trp Phe Val Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  42
<211>  113
<212>  PRT
<213>  Rattus norvegicus

<400>  42

Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Thr Leu Ser Leu Thr 
1               5                   10                  15      


Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn Gly Val Thr Trp Ile 
            20                  25                  30          


Arg His Pro Pro Gly Lys Gly Leu Glu Trp Met Gly Val Ile Trp Ser 
        35                  40                  45              


Asn Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys Ser Arg Leu Gly Ile 
    50                  55                  60                  


Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ala Arg Ala Ile Ala Ala 
                85                  90                  95      


Ser Tyr Val Met Asp Ala Trp Gly Pro Gly Ala Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  43
<211>  117
<212>  PRT
<213>  Rattus norvegicus

<400>  43

Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Thr 
1               5                   10                  15      


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Thr Gly 
            20                  25                  30          


Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Trp Ser Gly Gly Val Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
    50                  55                  60                  


Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Leu Leu Lys 
65                  70                  75                  80  


Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala Arg 
                85                  90                  95      


Thr Leu Ala Arg His Tyr Ile Met Asp Ala Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  44
<211>  118
<212>  PRT
<213>  Rattus norvegicus

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Leu Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Asp Gly Gly Thr Asp Tyr Asn Ser Ala Ile Arg 
    50                  55                  60                  


Ser Arg Leu Thr Leu Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Leu Ala Pro Ser Tyr Val Met Gly Pro Trp Gly Gln Gly Ala 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  45
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  45

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Pro Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Ile Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Met Ile Tyr Tyr Asp Ser Ser Lys Val Tyr Tyr Val Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro Leu Ile Thr Ile Ala Ala Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  46
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  46

Glu Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Phe Ser Leu Thr Ser Asp 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Asn Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Ser 
                85                  90                  95      


Arg Gly Gly Tyr Tyr Gly Tyr Asn Pro Ile Trp Phe Val Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  47
<211>  118
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  SITE
<222>  (13)..(13)
<223>  The amino acid at position 13 can be any naturally occuring amino
       acid

<220>
<221>  SITE
<222>  (59)..(59)
<223>  The amino acid at position 59 can be any naturally occuring amino
       acid

<400>  47

Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Xaa Pro Ser Lys 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Leu Ser Leu Thr Ser Asn 
            20                  25                  30          


Ser Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Arg Trp Met 
        35                  40                  45              


Gly Val Ile Trp Ser Asn Gly Gly Thr Asp Xaa Asn Ser Ala Ile Lys 
    50                  55                  60                  


Ser Arg Leu Ile Ile Ser Lys Asp Thr Ser Asn Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Leu Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Ile Ala Ser Ser Ser Val Val Asn Val Trp Gly Gln Gly Ser 
            100                 105                 110         


Ser Val Ala Val Ser Ser 
        115             


<210>  48
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  48

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Ile Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Met Ile Tyr Tyr Asp Ser Ser Lys Met Tyr Phe Ala Asp Thr Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Pro Leu Ile Thr Leu Ala Ala Gly Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  49
<211>  119
<212>  PRT
<213>  Rattus norvegicus

<400>  49

Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Ser Ser Val 
1               5                   10                  15      


Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn Thr Met 
            20                  25                  30          


His Trp Ile Lys Gln Thr Thr Gly Gln Ala Leu Glu Trp Thr Gly Tyr 
        35                  40                  45              


Ile Ser Pro Gly Ser Gly Gly Thr Met Tyr Asn Glu Lys Phe Lys Gly 
    50                  55                  60                  


Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
65                  70                  75                  80  


Leu Ser Ser Leu Thr Pro Val Asp Thr Ala Val Tyr Tyr Cys Val Arg 
                85                  90                  95      


Glu Gly Tyr Tyr Tyr Ser Arg Tyr Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  50
<211>  116
<212>  PRT
<213>  Rattus norvegicus

<400>  50

Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Leu Pro Ser Gln Thr 
1               5                   10                  15      


Leu Ser Leu Ser Cys Thr Val Ser Gly Leu Ser Leu Ile Ser Asn Ser 
            20                  25                  30          


Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Val Met Trp Asn Asn Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys Ser 
    50                  55                  60                  


Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu Lys 
65                  70                  75                  80  


Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala Arg 
                85                  90                  95      


Gly Tyr Ser Ser Tyr Ile Phe Asp Tyr Trp Gly Gln Gly Ala Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  51
<211>  118
<212>  PRT
<213>  Rattus norvegicus

<400>  51

Glu Val Gln Leu Thr Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Pro Gly Leu Ser Leu Thr Asn Thr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Trp Ser Asp Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Val 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Leu Ala Pro Ser Tyr Val Met Glu Ala Trp Gly Gln Gly Ala 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  52
<211>  117
<212>  PRT
<213>  Rattus norvegicus

<400>  52

Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Leu Ser Leu Thr Ser Asp 
            20                  25                  30          


Ser Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Trp Ser Asn Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg Thr Ile Pro Tyr Tyr Val Met Asp Ala Trp Gly Gln Gly Ala Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  53
<211>  118
<212>  PRT
<213>  Rattus norvegicus

<400>  53

Gln Val Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Leu Ser Leu Thr Ser Asn 
            20                  25                  30          


Ser Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Trp Ser Thr Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Ile Ala Ala Ser Ala Val Met Asp Ala Trp Gly Gln Gly Ala 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  54
<211>  117
<212>  PRT
<213>  Rattus norvegicus

<400>  54

Val Gln Leu Val Glu Ser Gly Pro Asp Leu Val Gln Pro Ser Gln Thr 
1               5                   10                  15      


Leu Ser Leu Thr Cys Thr Val Ser Gly Leu Ser Leu Thr Ser Thr Gly 
            20                  25                  30          


Val Ser Trp Ile Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Val Ile Trp Ser Asn Gly Gly Thr Asp Tyr Asn Ser Ala Ile Arg Ser 
    50                  55                  60                  


Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu Lys 
65                  70                  75                  80  


Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala Arg 
                85                  90                  95      


Ala Ile Ala Ala Ser Tyr Ile Met Asp Ala Trp Gly Gln Gly Ala Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  55
<211>  122
<212>  PRT
<213>  Rattus norvegicus

<400>  55

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser His 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Met Gly Val Ser Trp Val Arg Gln Pro Ser Gly Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Thr Ile Trp Trp Asn Gly Asn Thr Tyr Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Val Ser Lys Gly Thr Ser Asn Asn Gln Ala 
65                  70                  75                  80  


Phe Leu Lys Val Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala His Thr Leu Tyr Tyr Ser Thr Ser Ser Leu Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Val Val Val Thr Val Ser Ser 
        115                 120         


<210>  56
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  56

Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Thr 
1               5                   10                  15      


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asp Gly 
            20                  25                  30          


Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Ala 
        35                  40                  45              


Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
    50                  55                  60                  


Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu Lys 
65                  70                  75                  80  


Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr Arg 
                85                  90                  95      


Asp Thr Tyr Tyr Gly Tyr Asn Gln Ile Pro Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  57
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  57

Val Asn Leu Val Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Thr Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr Tyr 
            20                  25                  30          


Val His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Trp Ile Phe Pro Gly Ser Asp Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Ser Ile Tyr Tyr Gly Tyr Asp Gly Thr Leu Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  58
<211>  117
<212>  PRT
<213>  Rattus norvegicus

<400>  58

Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Thr 
1               5                   10                  15      


Leu Ser Leu Thr Cys Thr Val Ser Gly Leu Ser Leu Thr Ser Thr Gly 
            20                  25                  30          


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Val Ile Trp Ser Asn Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys Ser 
    50                  55                  60                  


Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu Lys 
65                  70                  75                  80  


Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala Arg 
                85                  90                  95      


Ala Ile Ala Pro Ser Tyr Ile Met Asp Ala Trp Gly Gln Gly Ala Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  59
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  59

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Ala Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Asn 
            20                  25                  30          


Thr Met His Trp Ile Lys Gln Thr Thr Gly Gln Ala Leu Glu Trp Thr 
        35                  40                  45              


Gly Tyr Ile Ser Pro Gly Ser Gly Gly Thr Met Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Pro Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Gly Tyr Tyr Tyr Ser Arg Tyr Ser Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  60
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  60

Gln Val Ser Leu Lys Glu Ser Gly Pro Gly Met Leu Gln Pro Ser Lys 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Val Val Asn Trp Ile Arg Gln Pro Ser Gly Lys Ser Leu Glu 
        35                  40                  45              


Trp Leu Ala Ala Ile Asp Trp Asp Gly Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys His Arg Leu Thr Val Ser Lys Asp Thr Ser Asn Thr Gln Val 
65                  70                  75                  80  


Val Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Ile Ala Pro Tyr Arg Gly Trp Phe Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  61
<211>  119
<212>  PRT
<213>  Rattus norvegicus

<400>  61

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Arg Pro Ser His 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Ile Cys Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Cys Trp Glu Asp Ser Lys Ala Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Arg Ile Pro Ser Val Asp Thr Ala Asp Ser Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Phe Asn Asn Tyr Pro Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  62
<211>  76
<212>  PRT
<213>  Rattus norvegicus

<400>  62

Gln Gly Thr Leu Lys Glu Ser Gly Pro Gly Ile Val Gln Ser Ser His 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Ser Val Trp Trp Asn Gly Asp Thr Ser Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser 
65                  70                  75      


<210>  63
<211>  124
<212>  PRT
<213>  Rattus norvegicus

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Ser 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Lys Trp Val 
        35                  40                  45              


Ala Ser Ile Arg Tyr Asp Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ser Thr Ala Lys Ala Ala Ile Ser Thr Pro Ser Tyr Tyr Val Leu Asp 
            100                 105                 110         


Ala Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  64
<211>  117
<212>  PRT
<213>  Rattus norvegicus

<400>  64

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Leu Ser Leu Ser Ser Asn 
            20                  25                  30          


Ser Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Trp Asn Asn Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Leu Gln Thr Glu Asp Thr Ala Met Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Tyr Ser Ser Tyr Ile Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  65
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Asn Thr Gly Gly Gly Thr Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Leu Ala Ala Pro Trp Asn Tyr Val Met Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  66
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  66

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Ala Gly Ser Thr Tyr Tyr Arg Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Val Ala Ala Pro Trp Asn Tyr Val Met Asp Gly Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  67
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ala Gly Ser Thr Tyr Tyr Arg Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Val Ala Ala Pro Trp Asn Tyr Val Met Asp Gly Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  68
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Gln Gly Ala Gly Ser Thr Tyr Tyr Arg Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Val Ala Ala Pro Trp Asn Tyr Val Met Asp Gly Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  69
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  69

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Thr Ile Thr Ser Gly 
            20                  25                  30          


Tyr Asp Trp Thr Trp Ile Arg Lys Pro Pro Gly Lys Gly Met Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Trp Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Gly Tyr Asn Pro Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  70
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  70

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asn 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Thr 
                85                  90                  95      


Arg Asp Thr Tyr Tyr Gly Tyr Asn Gln Ile Pro Phe Val Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  71
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  71

Glu Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Thr Ile Thr Ser Gly 
            20                  25                  30          


Tyr Asp Trp Thr Trp Leu Arg Lys Pro Pro Gly Lys Gly Met Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Phe Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Arg Gly Tyr Asn Pro Phe Pro Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  72
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  72

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Thr Ile Thr Ser Gly 
            20                  25                  30          


Tyr Asp Trp Ser Trp Ile Arg Lys Pro Pro Gly Lys Gly Met Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Trp Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Arg Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Arg Gly Tyr Asn Pro Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  73
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Ser His Gly Gly Asp Thr Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Ala Ala Pro Trp Asn Tyr Val Met Asp Gly Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  74
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Ser His Gly Gly Asp Thr Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Ala Ala Pro Trp Asn Tyr Val Met Asp Gly Trp Gly Gln 
            100                 105                 110         


Gly Ala Thr Val Thr Val Ser Ser 
        115                 120 


<210>  75
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  75

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Asp Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Ile Tyr Tyr Gly Tyr Asp Gly Thr Leu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  76
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  76

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Asp Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ile Tyr Tyr Gly Tyr Asp Gly Thr Leu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val 
        115                 120 


<210>  77
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  77

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Asp Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ile Tyr Tyr Gly Tyr Asp Gly Thr Leu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  78
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  78

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Arg Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Ser Asp Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ile Tyr Tyr Gly Tyr Asp Gly Thr Leu Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  79
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Phe 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Ser His Gly Gly Asp Thr Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ser Ala Ala Pro Trp Asn Tyr Val Met Gln Gly Trp Gly Gln 
            100                 105                 110         


Gly Ala Thr Val Thr Val Ser Ser 
        115                 120 


<210>  80
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  80

Gln Gly Thr Leu Lys Glu Ser Gly Pro Gly Ile Val Gln Ser Ser His 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Ser Val Trp Trp Asn Gly Asp Thr Ser Asn Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Val Ser Lys Asp Thr Ser Asn Asn Gln Ala 
65                  70                  75                  80  


Phe Leu Lys Val Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala His Thr Leu Tyr Asn Asn Tyr Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Met Val Thr Val Ser Ser 
        115                 120 


<210>  81
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  81

Asn Ser Tyr Ile Ser 
1               5   


<210>  82
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  82

Asn Asn Ala Met Ser 
1               5   


<210>  83
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  83

Gly Tyr Tyr Met His 
1               5   


<210>  84
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  84

Ser Gly Tyr Ile Ser 
1               5   


<210>  85
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  85

Asp Asp Tyr Val His 
1               5   


<210>  86
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  86

Asp Tyr Tyr Ile Asn 
1               5   


<210>  87
<211>  6
<212>  PRT
<213>  Rattus norvegicus

<400>  87

Ser Gly Tyr Asp Trp Ser 
1               5       


<210>  88
<211>  6
<212>  PRT
<213>  Rattus norvegicus

<400>  88

Ser Gly Tyr Asp Trp Thr 
1               5       


<210>  89
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  89

Ser Asn Gly Val Ser 
1               5   


<210>  90
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  90

Asp Tyr Thr Ile Thr 
1               5   


<210>  91
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  91

Ser Tyr Asn Val Asn 
1               5   


<210>  92
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  92

Arg Phe Tyr Met Ala 
1               5   


<210>  93
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  93

Ser Asn Tyr Ile Ser 
1               5   


<210>  94
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  94

Tyr Phe Tyr Met Ala 
1               5   


<210>  95
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  95

Asn Tyr Gly Met Ala 
1               5   


<210>  96
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  96

Ser Asn Gly Val Thr 
1               5   


<210>  97
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  97

Asp Thr Gly Val Ser 
1               5   


<210>  98
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  98

Asn Tyr Gly Met His 
1               5   


<210>  99
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  99

Ser Asp Gly Val Ser 
1               5   


<210>  100
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  100

Ser Asn Ser Val Ser 
1               5   


<210>  101
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  101

Ser Asn Thr Met His 
1               5   


<210>  102
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  102

Ser Asn Ser Ile Ser 
1               5   


<210>  103
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  103

Asn Thr Gly Val Ser 
1               5   


<210>  104
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  104

Ser Asp Ser Val Ser 
1               5   


<210>  105
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  105

Ser Thr Gly Val Ser 
1               5   


<210>  106
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  106

Thr Tyr Gly Met Gly Val Ser 
1               5           


<210>  107
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  107

Ser Tyr Tyr Val His 
1               5   


<210>  108
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  108

Thr Ser Gly Met Val Val Asn 
1               5           


<210>  109
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  109

Thr Tyr Gly Ile Cys Val Ser 
1               5           


<210>  110
<211>  5
<212>  PRT
<213>  Rattus norvegicus

<400>  110

Lys Ser Asp Met Ala 
1               5   


<210>  111
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  111

Trp Ile Tyr Ala Gly Thr Gly Gly Thr Asn Tyr Asn Gln Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  112
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  112

Thr Ile Thr Gly Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  113
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  113

Lys Ile Val Pro Ser Thr Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Ala 
    


<210>  114
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  114

Trp Ile Tyr Ala Gly Thr Gly Ile Ser Asn Phe Asn Gln Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  115

Arg Ile Asp Pro Ala Asn Gly Asn Thr Arg Tyr Ala Pro Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  116
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  116

Arg Ile Asp Pro Ala Gln Gly Asn Thr Arg Tyr Ala Pro Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  117
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  117

Arg Ile Asp Pro Ala Ser Gly Asn Thr Arg Tyr Ala Pro Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  118
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  118

Trp Ile Tyr Pro Gly Asn Val Asn Val Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  119
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  119

Tyr Ile Ser Tyr Ser Gly Trp Thr Asn Tyr Asn Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210>  120
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  120

Tyr Ile Ser Tyr Ser Gly Phe Thr Asn Tyr Asn Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210>  121
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  121

Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Val Leu Lys Ser 
1               5                   10                  15      


<210>  122
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  122

Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Gly Leu Lys Ser 
1               5                   10                  15      


<210>  123
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  123

Thr Ile Ser Ser Gly Gly Asn Thr Asn Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  124
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  124

Ala Thr Ser Val Gly Gly Ala Thr His Tyr Asn Ser Pro Leu Lys Ser 
1               5                   10                  15      


<210>  125
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  125

Tyr Ile Asn Thr Gly Gly Gly Thr Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  126
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  126

Tyr Ile Ser Asn Gly Ala Gly Ser Thr Tyr Tyr Arg Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  127
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  127

His Ile Ser His Gly Gly Asp Thr Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  128

Trp Ile Tyr Ser Gly Thr Gly Gly Thr Tyr Tyr Asn Gln Lys Phe Thr 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  129

Tyr Ile Ser Thr Gly Gly His Ser Thr Tyr Tyr Arg Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  130
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  130

Ser Ile Thr Asp Ser Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  131
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  131

Val Ile Trp Ser Asn Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys Ser 
1               5                   10                  15      


<210>  132
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  132

Ala Ile Trp Ser Gly Gly Val Thr Asp Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  133
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  133

Val Ile Trp Ser Asp Gly Gly Thr Asp Tyr Asn Ser Ala Ile Arg Ser 
1               5                   10                  15      


<210>  134
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  134

Met Ile Tyr Tyr Asp Ser Ser Lys Val Tyr Tyr Val Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  135
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  135

Thr Ile Ser Ser Gly Gly Asn Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  136
<211>  16
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  SITE
<222>  (10)..(10)
<223>  The amino acid at position 10 can be any naturally occuring amino
       acid

<400>  136

Val Ile Trp Ser Asn Gly Gly Thr Asp Xaa Asn Ser Ala Ile Lys Ser 
1               5                   10                  15      


<210>  137
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  137

Met Ile Tyr Tyr Asp Ser Ser Lys Met Tyr Phe Ala Asp Thr Leu Lys 
1               5                   10                  15      


Gly 
    


<210>  138
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  138

Tyr Ile Ser Pro Gly Ser Gly Gly Thr Met Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  139
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  139

Val Met Trp Asn Asn Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys Ser 
1               5                   10                  15      


<210>  140
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  140

Val Ile Trp Ser Asp Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys Ser 
1               5                   10                  15      


<210>  141
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  141

Val Ile Trp Ser Thr Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys Ser 
1               5                   10                  15      


<210>  142
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  142

Val Ile Trp Ser Asn Gly Gly Thr Asp Tyr Asn Ser Ala Ile Arg Ser 
1               5                   10                  15      


<210>  143
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  143

Thr Ile Trp Trp Asn Gly Asn Thr Tyr Asn Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  144
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  144

Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  145
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  145

Trp Ile Phe Pro Gly Ser Asp Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  146
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  146

Ala Ile Asp Trp Asp Gly Asp Lys Tyr Tyr Asn Pro Ser Leu Lys His 
1               5                   10                  15      


<210>  147
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  147

Asn Ile Cys Trp Glu Asp Ser Lys Ala Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  148
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  148

Ser Val Trp Trp Asn Gly Asp Thr Ser Asn Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  149
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  149

Ser Ile Arg Tyr Asp Gly Gly Asn Thr Tyr Tyr Arg Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  150
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  150

Val Ile Trp Asn Asn Gly Gly Thr Asp Tyr Asn Ser Ala Ile Lys Ser 
1               5                   10                  15      


<210>  151
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  151

Tyr Ile Ser Ser Gly Ala Gly Ser Thr Tyr Tyr Arg Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  152
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  152

Tyr Ile Ser Gln Gly Ala Gly Ser Thr Tyr Tyr Arg Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  153
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  153

Tyr Gly Asn Phe Leu Tyr Ala Met Asp Asn 
1               5                   10  


<210>  154
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  154

Pro Asp Gly Asn Tyr Glu Gly Val Leu Ala Tyr 
1               5                   10      


<210>  155
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  155

Glu Lys Val Tyr Gly Tyr Asp Val Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  156
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  156

Gly Ala Arg Lys Thr Leu Asp Phe 
1               5               


<210>  157
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  157

Pro Leu Trp Val Gly Gly Phe Ala Tyr 
1               5                   


<210>  158
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  158

Ser Ile Gly Leu Arg Tyr Phe Asp Asn 
1               5                   


<210>  159
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  159

Tyr Gly Asn Phe Leu Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  160
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  160

Val Arg Gly Tyr Asn Pro Phe Ala Tyr 
1               5                   


<210>  161
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  161

Thr Arg Gly Tyr Asn Pro Phe Ala Tyr 
1               5                   


<210>  162
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  162

Thr Arg Gly Tyr Asn Pro Phe Pro Tyr 
1               5                   


<210>  163
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  163

Asp Thr Tyr Tyr Gly Tyr Asn Gln Ile Pro Phe Val Tyr 
1               5                   10              


<210>  164
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  164

Ala Gly Tyr Tyr Gly Tyr Asn Pro Ile Trp Phe Thr Tyr 
1               5                   10              


<210>  165
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  165

Val Gly Tyr Tyr Gly Tyr Asn Pro Ile Trp Phe Ala Tyr 
1               5                   10              


<210>  166
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  166

Ser Gly Tyr Tyr Ser Thr Tyr Met Asn 
1               5                   


<210>  167
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  167

Ser Gly Tyr Tyr Ser Ser Tyr Met Asn 
1               5                   


<210>  168
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  168

Leu Ala Ala Pro Trp Asn Tyr Val Met Asp Ala 
1               5                   10      


<210>  169
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  169

Val Ala Ala Pro Trp Asn Tyr Val Met Asp Gly 
1               5                   10      


<210>  170
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  170

Ser Ala Ala Pro Trp Asn Tyr Val Met Asp Gly 
1               5                   10      


<210>  171
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  171

His Val Gly Leu Arg Tyr Trp Tyr Phe Asp Val 
1               5                   10      


<210>  172
<211>  14
<212>  PRT
<213>  Rattus norvegicus

<400>  172

Val Ser Gly Asp Tyr Ser Ser Tyr Ile Tyr Val Met Asp Ala 
1               5                   10                  


<210>  173
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  173

Leu Gly Val Pro Met Gly Met Ile Asn Trp Phe Val Tyr 
1               5                   10              


<210>  174
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  174

Ala Ile Ala Ala Ser Tyr Val Met Asp Ala 
1               5                   10  


<210>  175
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  175

Thr Leu Ala Arg His Tyr Ile Met Asp Ala 
1               5                   10  


<210>  176
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  176

Ala Leu Ala Pro Ser Tyr Val Met Gly Pro 
1               5                   10  


<210>  177
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  177

Pro Leu Ile Thr Ile Ala Ala Gly Phe Ala Tyr 
1               5                   10      


<210>  178
<211>  13
<212>  PRT
<213>  Rattus norvegicus

<400>  178

Gly Gly Tyr Tyr Gly Tyr Asn Pro Ile Trp Phe Val Tyr 
1               5                   10              


<210>  179
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  179

Ala Ile Ala Ser Ser Ser Val Val Asn Val 
1               5                   10  


<210>  180
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  180

Pro Leu Ile Thr Leu Ala Ala Gly Phe Thr Tyr 
1               5                   10      


<210>  181
<211>  12
<212>  PRT
<213>  Rattus norvegicus

<400>  181

Glu Gly Tyr Tyr Tyr Ser Arg Tyr Ser Phe Ala Tyr 
1               5                   10          


<210>  182
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  182

Gly Tyr Ser Ser Tyr Ile Phe Asp Tyr 
1               5                   


<210>  183
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  183

Ala Leu Ala Pro Ser Tyr Val Met Glu Ala 
1               5                   10  


<210>  184
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  184

Thr Ile Pro Tyr Tyr Val Met 
1               5           


<210>  185
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  185

Ala Ile Ala Ala Ser Ala Val Met Asp Ala 
1               5                   10  


<210>  186
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  186

Ala Ile Ala Ala Ser Tyr Ile Met Asp Ala 
1               5                   10  


<210>  187
<211>  12
<212>  PRT
<213>  Rattus norvegicus

<400>  187

Thr Leu Tyr Tyr Ser Thr Ser Ser Leu Phe Asp Tyr 
1               5                   10          


<210>  188
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  188

Ile Tyr Tyr Gly Tyr Asp Gly Thr Leu Tyr Phe Asp Tyr 
1               5                   10              


<210>  189
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  189

Ala Ile Ala Pro Ser Tyr Ile Met Asp Ala 
1               5                   10  


<210>  190
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  190

Ser Ile Ala Pro Tyr Arg Gly Trp Phe Gly Tyr 
1               5                   10      


<210>  191
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  191

Val Phe Asn Asn Tyr Pro Phe Pro Tyr 
1               5                   


<210>  192
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  192

Thr Leu Tyr Asn Asn Tyr Pro Phe Asp Tyr 
1               5                   10  


<210>  193
<211>  15
<212>  PRT
<213>  Rattus norvegicus

<400>  193

Ala Lys Ala Ala Ile Ser Thr Pro Ser Tyr Tyr Val Leu Asp Ala 
1               5                   10                  15  


<210>  194
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  194

Ser Ala Ala Pro Trp Asn Tyr Val Met Gln Gly 
1               5                   10      


<210>  195
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  195

Asp Ile Gln Met Lys Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Thr Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  196
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  196

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln His Tyr Ser Ser Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  197
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  197

Asp Ile Val Met Ser Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  198
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  198

Asp Ile Gln Met Thr Gln Ser Ser Ser Tyr Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp Gln Ile Asn Tyr Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Phe Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  199
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  199

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Val Asn Thr Tyr Leu His Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ser Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Thr 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  200
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  200

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Val Asn Thr Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Thr 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  201
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  201

Glu Lys Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Arg Ala Ser Ser Ser Val His Tyr Met 
            20                  25                  30          


Tyr Trp His Gln Gln Lys Ser Asp Ala Ser Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              


Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Phe Tyr Ser Leu Thr Ile Ser Ser Val Glu Asp Glu 
65                  70                  75                  80  


Asp Gly Ala Thr Tyr Tyr Cys Gln Gln Phe Thr Thr Ser Thr Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  202
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  202

Glu Lys Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val His Tyr Met 
            20                  25                  30          


Tyr Trp His Gln Gln Lys Pro Gly Gln Ser Pro Arg Leu Trp Ile Tyr 
        35                  40                  45              


Tyr Thr Ser Asn Leu Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Thr Thr Ser Thr Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  203
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  203

Asp Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Thr Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  204
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  204

Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Thr Ser Gln Gly Val Arg Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Ser Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  205
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  205

Glu Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  206
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  206

Asp Ile Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Ala Gly Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Ser Trp Thr Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  207
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  207

Asp Ile Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Ala Gly Arg Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Ser Trp Thr Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  208
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  208

Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Lys Ala Gly Arg Asn Val Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ser Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Ser Trp Thr Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  209
<211>  112
<212>  PRT
<213>  Rattus norvegicus

<400>  209

Asp Val Val Leu Ala Gln Thr Pro Pro Thr Leu Ser Ala Thr Ile Gly 
1               5                   10                  15      


Gln Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Ser Gly Asn Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Arg Leu Glu Ser Arg Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Ser 
                85                  90                  95      


Thr His Ala Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  210
<211>  112
<212>  PRT
<213>  Rattus norvegicus

<400>  210

Asp Val Val Met Thr Gln Thr Pro Pro Thr Leu Ser Ala Thr Ile Gly 
1               5                   10                  15      


Gln Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Gly 
            20                  25                  30          


Ser Gly Asn Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Ile Leu Ile Tyr Leu Val Ser Arg Leu Glu Ser Arg Val Pro 
    50                  55                  60                  


Lys Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Asp Asp Leu Gly Val Tyr Tyr Cys Val Gln Ser 
                85                  90                  95      


Thr His Ala Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  211
<211>  112
<212>  PRT
<213>  Rattus norvegicus

<400>  211

Asp Val Val Met Thr Gln Thr Pro Pro Thr Leu Ser Ala Thr Ile Gly 
1               5                   10                  15      


His Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe His Ser 
            20                  25                  30          


Ser Gly Asn Thr Tyr Leu Ser Trp Phe Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Arg Leu Glu Ser Arg Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Val Leu Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Thr 
                85                  90                  95      


Thr His Ala Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  212
<211>  112
<212>  PRT
<213>  Rattus norvegicus

<400>  212

Asp Val Val Met Thr Gln Thr Pro Pro Thr Phe Ser Ala Thr Ile Gly 
1               5                   10                  15      


Gln Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Ser Gly Asn Thr Phe Leu Ser Trp Leu Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Arg Leu Glu Phe Gly Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Ser 
                85                  90                  95      


Thr His Val Met Asn Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  213
<211>  112
<212>  PRT
<213>  Rattus norvegicus

<400>  213

Asp Val Val Met Thr Gln Thr Pro Pro Thr Leu Ser Ala Thr Ile Gly 
1               5                   10                  15      


Gln Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Arg Leu Glu Tyr Gly Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Ala Gln Ser 
                85                  90                  95      


Thr His Ala Leu Asn Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  214
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  214

Asp Val Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Thr 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  215
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  215

Asp Val Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Ala Gly Arg Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Thr Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Ser Trp Thr Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  216
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  216

Asn Ile Gln Ile Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  217
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  217

Asp Ile Val Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  218
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  218

Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  219
<211>  114
<212>  PRT
<213>  Rattus norvegicus

<400>  219

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Asn 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Glu Phe 
        


<210>  220
<211>  108
<212>  PRT
<213>  Rattus norvegicus

<400>  220

Val Met Thr Gln Ser Pro Val Leu Ala Val Ser Leu Gly Gln Arg Ala 
1               5                   10                  15      


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ile Ser Gly Ile Asn 
            20                  25                  30          


Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Gln Pro Arg Leu Leu 
        35                  40                  45              


Val Tyr Arg Ala Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln 
65                  70                  75                  80  


Ala Ala Asp Ile Ala Ala Tyr Tyr Cys Gln Gln Thr Arg Val Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  221
<211>  103
<212>  PRT
<213>  Rattus norvegicus

<400>  221

Val Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly Asp Arg Val 
1               5                   10                  15      


Thr Leu Ser Cys Lys Ala Gly Arg Asn Ile Asn Asn Tyr Leu Ala Trp 
            20                  25                  30          


Tyr Gln Gln Lys Leu Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asn Thr 
        35                  40                  45              


Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val 
65                  70                  75                  80  


Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Ser Trp Thr Thr Phe Gly Ser 
                85                  90                  95      


Gly Thr Lys Leu Glu Leu Lys 
            100             


<210>  222
<211>  103
<212>  PRT
<213>  Rattus norvegicus

<400>  222

Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly Asp Lys Val Thr 
1               5                   10                  15      


Ile Thr Cys Gln Ala Ser Gln Tyr Ile Tyr Lys Tyr Leu Ala Trp Tyr 
            20                  25                  30          


His Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile Arg Tyr Thr Ser 
        35                  40                  45              


Thr Leu Glu Ser Gly Thr Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser Gly Asp Phe Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Pro Phe Thr Phe Gly Ala 
                85                  90                  95      


Gly Thr Lys Leu Glu Leu Lys 
            100             


<210>  223
<211>  103
<212>  PRT
<213>  Rattus norvegicus

<400>  223

Met Ile Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly Asp Lys Val 
1               5                   10                  15      


Thr Ile Thr Cys Gln Ala Ser His Asn Ile Tyr Lys Tyr Val Ala Trp 
            20                  25                  30          


Phe Gln Leu Lys Pro Gly Arg Ala Pro Arg Leu Leu Ile Arg Tyr Thr 
        35                  40                  45              


Ser Thr Leu Gln Ser Gly Thr Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    50                  55                  60                  


Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser Glu Asp Phe 
65                  70                  75                  80  


Ala Ser Tyr Phe Cys Leu Gln Tyr Val Asn Leu Trp Thr Phe Gly Gly 
                85                  90                  95      


Gly Thr Lys Leu Glu Leu Lys 
            100             


<210>  224
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  224

Asp Ile Leu Met Thr Lys Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Ala Ser Gln His Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Arg Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Tyr Ala Ser Thr Leu Gln Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Thr Tyr Ser Phe Ser Ile Ser Asn Val Arg Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Ser Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  225
<211>  110
<212>  PRT
<213>  Mus musculus

<400>  225

Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly Gln 
1               5                   10                  15      


Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Asn Gly 
            20                  25                  30          


Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
        35                  40                  45              


Val Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn Pro 
65                  70                  75                  80  


Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Glu 
                85                  90                  95      


Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110 


<210>  226
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  226

Asp Ile Glu Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile His Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Leu 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Glu Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  227
<211>  115
<212>  PRT
<213>  Rattus norvegicus

<400>  227

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Trp Ser 
            20                  25                  30          


Gly Ser Gln Met Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Ala Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Gly Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      


His Tyr Asp Ser Leu Pro Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys 
        115 


<210>  228
<211>  112
<212>  PRT
<213>  Rattus norvegicus

<400>  228

Asp Val Val Met Thr Gln Thr Pro Pro Thr Leu Ser Ala Thr Ile Gly 
1               5                   10                  15      


Gln Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Ser Gly Asn Thr Tyr Leu His Trp Leu Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Val Tyr Leu Val Ser Arg Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Gly Ile Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Ser 
                85                  90                  95      


Thr His Ala Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  229
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  229

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile His Lys Tyr 
            20                  25                  30          


Ile Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Glu Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Tyr Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Ser Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  230
<211>  111
<212>  PRT
<213>  Rattus norvegicus

<400>  230

Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Thr Gly Glu Thr Val Thr 
1               5                   10                  15      


Ile Asn Cys Lys Ser Ser Gln Ser Leu Phe Trp Ser Gly Ser Gln Met 
            20                  25                  30          


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Thr Ser Thr Arg Gln Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln His His Tyr Asp Ser 
                85                  90                  95      


Leu Pro Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  231
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  231

Asp Val Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Ile Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Phe Gly Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Gln Tyr Ser Leu Lys Ile Ser Arg Leu Gln Leu 
65                  70                  75                  80  


Glu Asp Ile Gly Ile Tyr Tyr Cys Gln Gln Ala Ser Ser Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  232
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  232

Asp Ile Leu Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile His Gly Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Arg Leu Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Leu Thr Ser Thr Leu Glu Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Ser Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  233
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  233

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile His Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Gln Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Ser Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  234
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  234

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Ala Ser His Asn Ile Asn Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Arg Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Gln Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Ser Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  235
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  235

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile His Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Arg His Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Gln Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Ser Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  236
<211>  103
<212>  PRT
<213>  Rattus norvegicus

<400>  236

Met Ile Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly Asp Lys Val 
1               5                   10                  15      


Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile His Thr Tyr Leu Ala Trp 
            20                  25                  30          


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile Arg Tyr Thr 
        35                  40                  45              


Ser Thr Leu Glu Ser Gly Thr Pro Ser Arg Phe Ser Gly Gly Gly Ser 
    50                  55                  60                  


Gly Arg His Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser Glu Asp Val 
65                  70                  75                  80  


Ala Ser Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Pro Thr Phe Gly Gly 
                85                  90                  95      


Gly Thr Lys Leu Glu Leu Lys 
            100             


<210>  237
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  237

Asn Ile Gln Leu Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Asn Leu Glu Leu Lys 
            100                 105     


<210>  238
<211>  112
<212>  PRT
<213>  Rattus norvegicus

<400>  238

Asp Val Val Leu Thr Gln Thr Pro Pro Thr Leu Ser Ala Thr Ile Gly 
1               5                   10                  15      


Gln Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Ser Gly Asn Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Phe Leu Ile Tyr Leu Val Ser Arg Leu Glu Ser Arg Val Pro 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Gly Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Ser 
                85                  90                  95      


Thr Pro Ala Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  239
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  239

Asp Ile Val Met Thr Gln Ser His Thr Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Asn Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Asn Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asp Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  240
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  240

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile His Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Arg Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Gln Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Ser Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  241
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  241

Glu Ile Val Leu Ile Gln Ser Pro Ser Ser Leu Pro Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Ile Cys Arg Ala Ser Gln Asp Ile Gly Asn Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Pro Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Asn Phe Gln Ser Gly Val Pro Ser Ser Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Asp Ala Ser Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  242
<211>  102
<212>  PRT
<213>  Rattus norvegicus

<400>  242

Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly Asp Lys Val Thr 
1               5                   10                  15      


Ile Thr Cys Gln Ala Ser Gln Asn Ile Asn Lys Tyr Val Ala Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile Arg Tyr Thr Ser 
        35                  40                  45              


Thr Leu Glu Ser Gly Thr Pro Ser Arg Phe Ser Gly Ser Gly Ser Trp 
    50                  55                  60                  


Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser Glu Asp Ile Ala 
65                  70                  75                  80  


Asp Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Trp Thr Phe Gly Gly Gly 
                85                  90                  95      


Thr Lys Leu Glu Leu Lys 
            100         


<210>  243
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  243

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu His Phe Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Arg Tyr Tyr Cys Gln Gln Tyr Val Lys Phe Pro Asn 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Ile Leu Glu Leu Lys 
            100                 105         


<210>  244
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  244

Asp Ile Gly Met Thr Gln Ser Pro Thr Ser Met Ser Lys Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Asn Cys Lys Ala Ser Gln Asn Val Gly Ser Asn 
            20                  25                  30          


Val Asp Trp Phe Gln Gln Lys Thr Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ser Ser Asn Arg Tyr Thr Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Met Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Met Gln Ser Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  245
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  245

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Ser Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Arg Val Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Gln Ser Gly Ala Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Trp Arg Asp Tyr Ser Phe Thr Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  246
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  246

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Ser Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  247
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  247

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asp Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  248
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  248

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Gln Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  249
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  249

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  250
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  250

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gly Arg Asn Val Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ser Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Tyr Cys Gln Gln Tyr Asn Ser Trp Thr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  251
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  251

Asp Val Val Leu Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Ser Gly Asn Thr Tyr Leu Asn Trp Leu Leu Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Val Ser Arg Leu Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Val Gln Ser 
                85                  90                  95      


Thr His Ala Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  252
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  252

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  253
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  253

Asp Ile Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  254
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  254

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gly Arg Asn Val Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ser Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Thr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  255
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  255

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Gly Gln Asn Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Thr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  256
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  256

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Asn Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  257
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  257

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Asn Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Asp Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  258
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  258

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Asn Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  259
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  259

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Val Gly Asn Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Arg Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  260
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  260

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Asn Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  261
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  261

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Asn Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  262
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  262

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Val Thr Cys Lys Ala Ser Gln Asn Val Gly Asn Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Arg Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  263
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  263

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Gln Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  264
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  264

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Lys Gly Ser Gln Asn Ile Asn Asn Phe 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Asn Ser Leu His Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Ser Gly Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  265
<211>  107
<212>  PRT
<213>  Rattus norvegicus

<400>  265

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Lys Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Asp Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Ser Tyr Tyr Cys Gln Gln Tyr Val Asn Phe Pro Asn 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Asn Leu Glu Leu Lys 
            100                 105         


<210>  266
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  266

Arg Ala Ser Gly Asn Ile His Asn Tyr Leu Ala 
1               5                   10      


<210>  267
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  267

Ser Ala Ser Gln Gly Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  268
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  268

Arg Ala Ser Gln Ser Ile Ser Asp Tyr Leu His 
1               5                   10      


<210>  269
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  269

Lys Ala Ser Asp Gln Ile Asn Tyr Trp Leu Ala 
1               5                   10      


<210>  270
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  270

Arg Ser Ser Gln Ser Leu Val His Ser Asp Val Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  271
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  271

Arg Ala Ser Ser Ser Val His Tyr Met Tyr 
1               5                   10  


<210>  272
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  272

Ser Thr Ser Gln Gly Val Arg Ser Tyr Leu Asn 
1               5                   10      


<210>  273
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  273

Lys Ala Gly Gln Asn Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  274
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  274

Lys Ala Gly Arg Asn Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  275
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  275

Lys Ala Gly Arg Asn Val Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  276
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  276

Arg Ser Ser Gln Ser Leu Leu His Ser Ser Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  277
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  277

Arg Ser Ser Gln Ser Leu Leu His Gly Ser Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  278
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  278

Arg Ser Ser Gln Ser Leu Phe His Ser Ser Gly Asn Thr Tyr Leu Ser 
1               5                   10                  15      


<210>  279
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  279

Arg Ser Ser Gln Ser Leu Leu His Ser Ser Gly Asn Thr Phe Leu Ser 
1               5                   10                  15      


<210>  280
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  280

Arg Ser Ser Gln Ser Leu Leu His Ser Thr Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  281
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  281

Lys Gly Ser Gln Asn Ile Asn Asn Phe Leu Ala 
1               5                   10      


<210>  282
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  282

Lys Gly Ser Gln Asn Ile Asn Asn Tyr Leu Ala 
1               5                   10      


<210>  283
<211>  15
<212>  PRT
<213>  Rattus norvegicus

<400>  283

Arg Ala Ser Glu Ser Val Asp Ser Asn Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  284
<211>  15
<212>  PRT
<213>  Rattus norvegicus

<400>  284

Arg Ala Ser Gln Ser Val Thr Ile Ser Gly Ile Asn Leu Met His 
1               5                   10                  15  


<210>  285
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  285

Gln Ala Ser Gln Tyr Ile Tyr Lys Tyr Leu Ala 
1               5                   10      


<210>  286
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  286

Gln Ala Ser His Asn Ile Tyr Lys Tyr Val Ala 
1               5                   10      


<210>  287
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  287

Gln Ala Ser Gln His Ile Asn Asn Tyr Ile Ala 
1               5                   10      


<210>  288
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  288

Gln Ala Ser Gln Asn Ile His Lys Tyr Ile Ala 
1               5                   10      


<210>  289
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  289

Lys Ser Ser Gln Ser Leu Phe Trp Ser Gly Ser Gln Met Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  290
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  290

Arg Ser Ser Gln Ser Leu Leu His Ser Ser Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  291
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  291

Gln Ala Ser Gln Asn Ile His Lys Tyr Ile Gly 
1               5                   10      


<210>  292
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  292

Gln Ala Ser Gln Asp Ile Gly Ile Trp Leu Ala 
1               5                   10      


<210>  293
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  293

Gln Ala Ser Gln Asn Ile His Gly Tyr Ile Ala 
1               5                   10      


<210>  294
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  294

Gln Ala Ser His Asn Ile Asn Lys Tyr Ile Ala 
1               5                   10      


<210>  295
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  295

Gln Ala Ser Gln Asn Ile His Thr Tyr Leu Ala 
1               5                   10      


<210>  296
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  296

Lys Ala Ser Gln Asn Val Gly Asn Asn Val Ala 
1               5                   10      


<210>  297
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  297

Arg Ala Ser Gln Asp Ile Gly Asn Asn Leu Asn 
1               5                   10      


<210>  298
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  298

Gln Ala Ser Gln Asn Ile Asn Lys Tyr Val Ala 
1               5                   10      


<210>  299
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  299

Gln Ala Ser Gln Asn Ile Tyr Lys Tyr Ile Ala 
1               5                   10      


<210>  300
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  300

Lys Ala Ser Gln Asn Val Gly Ser Asn Val Asp 
1               5                   10      


<210>  301
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  301

Gln Ser Ser Gln Asn Ile Asn Asn Tyr Ile Ala 
1               5                   10      


<210>  302
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  302

Asn Thr Lys Thr Leu Ala Asp 
1               5           


<210>  303
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  303

Tyr Thr Ser Thr Leu His Ser 
1               5           


<210>  304
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  304

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  305
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  305

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  306
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  306

Tyr Thr Ser Asn Leu Ala Pro 
1               5           


<210>  307
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  307

Tyr Thr Ser Ser Leu His Ser 
1               5           


<210>  308
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  308

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  309
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  309

Asn Ala Asn Ser Leu Gln Thr 
1               5           


<210>  310
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  310

Asn Thr Asn Ser Leu Gln Thr 
1               5           


<210>  311
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  311

Asn Ser Asn Ser Leu Gln Thr 
1               5           


<210>  312
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  312

Leu Val Ser Arg Leu Glu Ser 
1               5           


<210>  313
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  313

Leu Val Ser Arg Leu Glu Phe 
1               5           


<210>  314
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  314

Leu Val Ser Arg Leu Glu Tyr 
1               5           


<210>  315
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  315

Lys Thr Asn Ser Leu His Thr 
1               5           


<210>  316
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  316

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  317
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  317

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  318
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  318

Tyr Thr Ser Thr Leu Glu Ser 
1               5           


<210>  319
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  319

Tyr Thr Ser Thr Leu Gln Ser 
1               5           


<210>  320
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  320

Tyr Ala Ser Thr Leu Gln Ser 
1               5           


<210>  321
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  321

Tyr Ala Ser Thr Ala Gln Ser 
1               5           


<210>  322
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  322

Tyr Thr Ser Thr Arg Gln Ser 
1               5           


<210>  323
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  323

Gly Ala Thr Ser Leu Ala Asp 
1               5           


<210>  324
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  324

Leu Thr Ser Thr Leu Glu Ser 
1               5           


<210>  325
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  325

Ser Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  326
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  326

Phe Thr Ser Asn Phe Gln Ser 
1               5           


<210>  327
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  327

Tyr Thr Ser Thr Leu His Phe 
1               5           


<210>  328
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  328

Lys Ser Ser Asn Arg Tyr Thr 
1               5           


<210>  329
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  329

Tyr Thr Ser Thr Leu Asp Ser 
1               5           


<210>  330
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  330

Gln His Phe Trp Ser Thr Pro Trp Thr 
1               5                   


<210>  331
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  331

Gln His Tyr Ser Ser Leu Pro Trp Thr 
1               5                   


<210>  332
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  332

Gln Asn Gly His Ser Phe Pro Trp Thr 
1               5                   


<210>  333
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  333

Gln Gln Tyr Trp Thr Thr Pro Tyr Thr 
1               5                   


<210>  334
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  334

Ser Gln Thr Thr His Val Pro Tyr Thr 
1               5                   


<210>  335
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  335

Gln Gln Phe Thr Thr Ser Thr Trp Thr 
1               5                   


<210>  336
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  336

Gln Gln Tyr Ser Lys Leu Pro Tyr Thr 
1               5                   


<210>  337
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  337

Gln Gln Tyr Asn Ser Trp Thr Thr 
1               5               


<210>  338
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  338

Val Gln Ser Thr His Ala Pro Arg Thr 
1               5                   


<210>  339
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  339

Val Gln Ser Thr His Ala Pro Phe Thr 
1               5                   


<210>  340
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  340

Val Gln Thr Thr His Ala Pro Phe Thr 
1               5                   


<210>  341
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  341

Val Gln Ser Thr His Val Met Asn Thr 
1               5                   


<210>  342
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  342

Ala Gln Ser Thr His Ala Leu Asn Thr 
1               5                   


<210>  343
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  343

Tyr Gln Tyr Asn Asn Gly Tyr Thr 
1               5               


<210>  344
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  Rattus norvegicus or Mus musculus

<400>  344

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  345
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  345

Gln Gln Thr Arg Val Ser Pro Trp Thr 
1               5                   


<210>  346
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  346

Leu Gln Tyr Val Asn Leu Pro Phe Thr 
1               5                   


<210>  347
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  347

Leu Gln Tyr Val Asn Leu Trp Thr 
1               5               


<210>  348
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  348

Leu Gln Tyr Val Asn Leu Pro Tyr Thr 
1               5                   


<210>  349
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  349

Gln His His Tyr Asp Ser Leu Pro Pro Tyr Thr 
1               5                   10      


<210>  350
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  350

Gln Gln Ala Ser Ser Ala Pro Trp Thr 
1               5                   


<210>  351
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  351

Leu Gln Tyr Val Asn Leu Pro Thr 
1               5               


<210>  352
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  352

Val Gln Ser Thr Pro Ala Pro Arg Thr 
1               5                   


<210>  353
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  353

Gln Gln Tyr Asp Arg Tyr Pro Leu Thr 
1               5                   


<210>  354
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  354

Gln Gln Asp Ala Ser Leu Pro Trp Thr 
1               5                   


<210>  355
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  355

Gln Gln Tyr Val Lys Phe Pro Asn Thr 
1               5                   


<210>  356
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  356

Met Gln Ser Asn Ser Tyr Pro Pro Thr 
1               5                   


<210>  357
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  357

Tyr Gln Tyr Asn Ser Gly Tyr Thr 
1               5               


<210>  358
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  358

Tyr Gln Tyr Asn Asp Gly Tyr Thr 
1               5               


<210>  359
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  359

Tyr Gln Tyr Asn Gln Gly Tyr Thr 
1               5               


<210>  360
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  360

Cys Gln Gln Tyr Asn Ser Trp Thr Thr 
1               5                   


<210>  361
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  361

Gln Gln Tyr Val Asn Phe Pro Asn Thr 
1               5                   


<210>  362
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  362

Val Ala Thr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  363
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  363

Val Ala Thr Ile Ser Ser Gly Gly Gly Gln Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  364
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  humanized sequence

<400>  364

Val Ala Thr Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  365
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  365

Ala Arg Tyr Gly Ala Gly Asp Ala Trp Phe Ala Tyr 
1               5                   10          


<210>  366
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  366

Glu Val Met Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Asn 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Thr Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Gly Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Asp Gly Asn Tyr Glu Gly Val Leu Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser 
        115                 


<210>  367
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  367

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Leu Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Phe Pro Arg Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  368
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  368

Arg Ser Ser Gln Ser Ile Val His Ser Thr Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  369
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  369

Gln Gly Ser His Phe Pro Arg Thr 
1               5               


<210>  370
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (35)..(35)
<223>  The amino acid at position 35 is Asn, Gln or Ser

<400>  370

Asp Val Leu Met Thr Gln Thr Pro Val Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Thr Gly Xaa Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Ser His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  371
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (12)..(12)
<223>  The amino acid at position 12 is Asn, Gln or Ser

<400>  371

Arg Ser Ser Gln Ser Ile Val His Ser Thr Gly Xaa Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  372
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  372

Lys Ile Ser Asn Arg Phe Ser 
1               5           


<210>  373
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  373

Phe Gln Ala Ser His Phe Pro Arg Thr 
1               5                   


<210>  374
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  374

Asp Val Leu Met Thr Gln Thr Pro Val Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Thr Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Ser His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  375
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (35)..(35)
<223>  The amino acid at position 35 is Asn, Gln or Ser

<400>  375

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Thr Gly Xaa Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Pro 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Ala 
                85                  90                  95      


Ser His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  376
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (12)..(12)
<223>  The amino acid at position 12 is Asn, Gln or Ser

<400>  376

Arg Ser Ser Gln Ser Ile Val His Ser Thr Gly Xaa Thr Tyr Leu Glu 
1               5                   10                  15      


Trp 
    


<210>  377
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  377

Lys Ile Ser Asn Arg Phe Ser Gly 
1               5               


<210>  378
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  378

Phe Gln Ala Ser His Phe Pro Arg Thr Phe 
1               5                   10  


<210>  379
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  379

Glu Val Ile Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Arg Tyr Glu Ala Trp Phe Ala Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  380
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  380

Glu Val Lys Val Val Glu Ser Gly Gly Val Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Met Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Ala Gly Asp Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  381
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (57)..(57)
<223>  The amino acid at position 57 is Asn, Gln or Ser

<400>  381

Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Xaa Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Ala Gly Asp Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala 
        115                 120 


<210>  382
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  382

Arg Tyr Thr Met Ser 
1               5   


<210>  383
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (8)..(8)
<223>  The amino acid at position 8 is Asn, Gln or Ser

<400>  383

Thr Ile Ser Ser Gly Gly Gly Xaa Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  384
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  384

Tyr Gly Ala Gly Asp Ala Trp Phe Ala Tyr 
1               5                   10  


<210>  385
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  385

Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Ala Gly Asp Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  386
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  386

Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Gln Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Ala Gly Asp Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  387
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  387

Glu Val Gln Leu Val Glu Ser Gly Gly Val Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Ala Gly Asp Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  388
<211>  121
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  388

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Ser Ile Phe Gly Val Gly Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  389
<211>  450
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  389

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  390
<211>  451
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  390

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Val Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Ser Ile Phe Gly Val Gly Thr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Leu Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  391
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  391

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  392
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  392

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Thr Ile Tyr Pro Gly Asn Asp Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Arg Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  393
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  393

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110         


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560 


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590         


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605             


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620                 


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640 


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655 


<210>  394
<211>  657
<212>  PRT
<213>  Mus musculus

<400>  394

Met Ser Ser Ser Asn Asp His Val Leu Val Pro Met Ser Gln Arg Asn 
1               5                   10                  15      


Asn Asn Gly Leu Pro Arg Thr Asn Ser Arg Ala Val Arg Thr Leu Ala 
            20                  25                  30          


Glu Gly Asp Val Leu Ser Phe His His Ile Thr Tyr Arg Val Lys Val 
        35                  40                  45              


Lys Ser Gly Phe Leu Val Arg Lys Thr Val Glu Lys Glu Ile Leu Ser 
    50                  55                  60                  


Asp Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly Pro 
65                  70                  75                  80  


Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg Lys 
                85                  90                  95      


Asp Pro Lys Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro Gln 
            100                 105                 110         


Pro Ala His Phe Lys Cys Cys Ser Gly Tyr Val Val Gln Asp Asp Val 
        115                 120                 125             


Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala Ala 
    130                 135                 140                 


Leu Arg Leu Pro Thr Thr Met Lys Asn His Glu Lys Asn Glu Arg Ile 
145                 150                 155                 160 


Asn Thr Ile Ile Lys Glu Leu Gly Leu Glu Lys Val Ala Asp Ser Lys 
                165                 170                 175     


Val Gly Thr Gln Phe Ile Arg Gly Ile Ser Gly Gly Glu Arg Lys Arg 
            180                 185                 190         


Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe Leu 
        195                 200                 205             


Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val Leu 
    210                 215                 220                 


Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe Ser 
225                 230                 235                 240 


Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu Thr 
                245                 250                 255     


Leu Leu Ala Ser Gly Lys Leu Val Phe His Gly Pro Ala Gln Lys Ala 
            260                 265                 270         


Leu Glu Tyr Phe Ala Ser Ala Gly Tyr His Cys Glu Pro Tyr Asn Asn 
        275                 280                 285             


Pro Ala Asp Phe Phe Leu Asp Val Ile Asn Gly Asp Ser Ser Ala Val 
    290                 295                 300                 


Met Leu Asn Arg Glu Glu Gln Asp Asn Glu Ala Asn Lys Thr Glu Glu 
305                 310                 315                 320 


Pro Ser Lys Gly Glu Lys Pro Val Ile Glu Asn Leu Ser Glu Phe Tyr 
                325                 330                 335     


Ile Asn Ser Ala Ile Tyr Gly Glu Thr Lys Ala Glu Leu Asp Gln Leu 
            340                 345                 350         


Pro Gly Ala Gln Glu Lys Lys Gly Thr Ser Ala Phe Lys Glu Pro Val 
        355                 360                 365             


Tyr Val Thr Ser Phe Cys His Gln Leu Arg Trp Ile Ala Arg Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Val Ala Gln Leu Ile 
385                 390                 395                 400 


Val Thr Val Ile Leu Gly Leu Ile Ile Gly Ala Ile Tyr Phe Asp Leu 
                405                 410                 415     


Lys Tyr Asp Ala Ala Gly Met Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Phe Gly Lys Val Met Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Phe Leu Pro Ser Val Ile Phe Thr Cys Val Leu Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Lys Thr Val Asp Ala Phe Phe Ile Met Met Phe Thr 
            500                 505                 510         


Leu Ile Met Val Ala Tyr Thr Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Thr Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Ala 
    530                 535                 540                 


Phe Val Phe Met Met Leu Phe Ser Gly Leu Leu Val Asn Leu Arg Thr 
545                 550                 555                 560 


Ile Gly Pro Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln Tyr Asn Glu Phe Leu Gly Gln Glu Phe Cys 
            580                 585                 590         


Pro Gly Phe Asn Val Thr Asp Asn Ser Thr Cys Val Asn Ser Tyr Ala 
        595                 600                 605             


Ile Cys Thr Gly Asn Glu Tyr Leu Ile Asn Gln Gly Ile Glu Leu Ser 
    610                 615                 620                 


Pro Trp Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Ile 
625                 630                 635                 640 


Ile Phe Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr 
                645                 650                 655     


Ser 
    


<210>  395
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  395

Asp Leu Lys Tyr Asp Ala Ala Gly Met Gln Asn Arg Ala Gly 
1               5                   10                  


<210>  396
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  396

Leu Lys Lys Thr Val Asp Ala Phe 
1               5               


<210>  397
<211>  76
<212>  PRT
<213>  Mus musculus

<400>  397

Asn Leu Arg Thr Ile Gly Pro Trp Leu Ser Trp Leu Gln Tyr Phe Ser 
1               5                   10                  15      


Ile Pro Arg Tyr Gly Phe Thr Ala Leu Gln Tyr Asn Glu Phe Leu Gly 
            20                  25                  30          


Gln Glu Phe Cys Pro Gly Phe Asn Val Thr Asp Asn Ser Thr Cys Val 
        35                  40                  45              


Asn Ser Tyr Ala Ile Cys Thr Gly Asn Glu Tyr Leu Ile Asn Gln Gly 
    50                  55                  60                  


Ile Glu Leu Ser Pro Trp Gly Leu Trp Lys Asn His 
65                  70                  75      


<210>  398
<211>  655
<212>  PRT
<213>  Macaca fascicularis

<400>  398

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Met Ser Gln Glu Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Thr Thr Thr Ser Asn Asp Arg Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Val 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Gly Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Leu 
            100                 105                 110         


Arg Pro Thr Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Pro Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Arg Asp Lys Pro Leu Val Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asp Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Ile Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Asn Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Phe Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Thr Ala Asp Ala Phe Phe Ile Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560 


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590         


Pro Gly Leu Asn Ala Thr Val Asn Asn Thr Cys Asn Tyr Ala Thr Cys 
        595                 600                 605             


Thr Gly Glu Glu Tyr Leu Thr Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620                 


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640 


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655 


<210>  399
<211>  12
<212>  PRT
<213>  Macaca fascicularis

<400>  399

Asn Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly 
1               5                   10          


<210>  400
<211>  8
<212>  PRT
<213>  Macaca fascicularis

<400>  400

Leu Lys Pro Thr Ala Asp Ala Phe 
1               5               


<210>  401
<211>  74
<212>  PRT
<213>  Macaca fascicularis

<400>  401

Asn Leu Thr Thr Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser 
1               5                   10                  15      


Ile Pro Arg Tyr Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly 
            20                  25                  30          


Gln Asn Phe Cys Pro Gly Leu Asn Ala Thr Val Asn Asn Thr Cys Asn 
        35                  40                  45              


Tyr Ala Thr Cys Thr Gly Glu Glu Tyr Leu Thr Lys Gln Gly Ile Asp 
    50                  55                  60                  


Leu Ser Pro Trp Gly Leu Trp Lys Asn His 
65                  70                  


<210>  402
<211>  655
<212>  PRT
<213>  Pan troglodytes

<400>  402

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Met Ser Gln Gly Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Ala Thr Thr Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110         


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Pro Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Ile Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560 


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590         


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605             


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620                 


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640 


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655 


<210>  403
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  403

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Lys Ser Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110         


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Gln Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560 


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590         


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605             


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620                 


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640 


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655 


<210>  404
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  404

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Met Ala Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110         


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Gln Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560 


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590         


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605             


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620                 


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640 


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655 


<210>  405
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  405

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Met Ala Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110         


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Ala Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Arg Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560 


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590         


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605             


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620                 


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640 


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655 


<210>  406
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  406

Met Ser Ser Ser Asn Val Glu Val Phe Ile Pro Val Ser Gln Gly Asn 
1               5                   10                  15      


Thr Asn Gly Phe Pro Ala Thr Ala Ser Asn Asp Leu Lys Ala Phe Thr 
            20                  25                  30          


Glu Gly Ala Val Leu Ser Phe His Asn Ile Cys Tyr Arg Val Lys Leu 
        35                  40                  45              


Lys Ser Gly Phe Leu Pro Cys Arg Lys Pro Val Glu Lys Glu Ile Leu 
    50                  55                  60                  


Ser Asn Ile Asn Gly Ile Met Lys Pro Gly Leu Asn Ala Ile Leu Gly 
65                  70                  75                  80  


Pro Thr Gly Gly Gly Met Ala Ser Leu Leu Asp Val Leu Ala Ala Arg 
                85                  90                  95      


Lys Asp Pro Ser Gly Leu Ser Gly Asp Val Leu Ile Asn Gly Ala Pro 
            100                 105                 110         


Arg Pro Ala Asn Phe Lys Cys Asn Ser Gly Tyr Val Val Ala Asp Asp 
        115                 120                 125             


Val Val Met Gly Thr Leu Thr Val Arg Glu Asn Leu Gln Phe Ser Ala 
    130                 135                 140                 


Ala Leu Arg Leu Ala Thr Thr Met Thr Asn His Glu Lys Asn Glu Arg 
145                 150                 155                 160 


Ile Asn Arg Val Ile Gln Glu Leu Gly Leu Asp Lys Val Ala Asp Ser 
                165                 170                 175     


Lys Val Gly Thr Gln Phe Ile Arg Gly Val Ser Gly Gly Glu Arg Lys 
            180                 185                 190         


Arg Thr Ser Ile Gly Met Glu Leu Ile Thr Asp Pro Ser Ile Leu Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ser Ser Thr Ala Asn Ala Val 
    210                 215                 220                 


Leu Leu Leu Leu Lys Arg Met Ser Lys Gln Gly Arg Thr Ile Ile Phe 
225                 230                 235                 240 


Ser Ile His Gln Pro Glu Tyr Ser Ile Phe Lys Leu Phe Asp Ser Leu 
                245                 250                 255     


Thr Leu Leu Ala Ser Gly Arg Leu Met Phe His Gly Pro Ala Gln Glu 
            260                 265                 270         


Ala Leu Gly Tyr Phe Glu Ser Ala Gly Tyr His Cys Glu Ala Tyr Asn 
        275                 280                 285             


Asn Pro Ala Asp Phe Phe Leu Asp Ile Ile Asn Gly Asp Ser Thr Ala 
    290                 295                 300                 


Val Ala Leu Asn Arg Glu Glu Asp Phe Lys Ala Thr Glu Ile Ile Glu 
305                 310                 315                 320 


Pro Ser Lys Gln Asp Lys Pro Leu Ile Glu Lys Leu Ala Glu Ile Tyr 
                325                 330                 335     


Val Asn Ser Ser Phe Tyr Lys Glu Thr Lys Ala Glu Leu His Gln Leu 
            340                 345                 350         


Ser Gly Gly Glu Lys Lys Lys Lys Ile Thr Val Phe Lys Glu Ile Ser 
        355                 360                 365             


Tyr Thr Thr Ser Phe Cys His Gln Leu Arg Trp Val Ser Lys Arg Ser 
    370                 375                 380                 


Phe Lys Asn Leu Leu Gly Asn Pro Gln Ala Ser Ile Ala Gln Ile Ile 
385                 390                 395                 400 


Val Thr Val Val Leu Gly Leu Val Ile Gly Ala Ile Tyr Phe Gly Leu 
                405                 410                 415     


Lys Asn Asp Ser Thr Gly Ile Gln Asn Arg Ala Gly Val Leu Phe Phe 
            420                 425                 430         


Leu Thr Thr Asn Gln Cys Phe Ser Ser Val Ser Ala Val Glu Leu Phe 
        435                 440                 445             


Val Val Glu Lys Lys Leu Phe Ile His Glu Tyr Ile Ser Gly Tyr Tyr 
    450                 455                 460                 


Arg Val Ser Ser Tyr Phe Leu Gly Lys Leu Leu Ser Asp Leu Leu Pro 
465                 470                 475                 480 


Met Arg Met Leu Pro Ser Ile Ile Phe Thr Cys Ile Val Tyr Phe Met 
                485                 490                 495     


Leu Gly Leu Lys Pro Lys Ala Asp Ala Phe Phe Val Met Met Phe Thr 
            500                 505                 510         


Leu Met Met Val Ala Tyr Ser Ala Ser Ser Met Ala Leu Ala Ile Ala 
        515                 520                 525             


Ala Gly Gln Ser Val Val Ser Val Ala Thr Leu Leu Met Thr Ile Cys 
    530                 535                 540                 


Phe Val Phe Met Met Ile Phe Ser Gly Leu Leu Val Asn Leu Thr Thr 
545                 550                 555                 560 


Ile Ala Ser Trp Leu Ser Trp Leu Gln Tyr Phe Ser Ile Pro Arg Tyr 
                565                 570                 575     


Gly Phe Thr Ala Leu Gln His Asn Glu Phe Leu Gly Gln Asn Phe Cys 
            580                 585                 590         


Pro Gly Leu Asn Ala Thr Gly Asn Asn Pro Cys Asn Tyr Ala Thr Cys 
        595                 600                 605             


Thr Gly Glu Glu Tyr Leu Val Lys Gln Gly Ile Asp Leu Ser Pro Trp 
    610                 615                 620                 


Gly Leu Trp Lys Asn His Val Ala Leu Ala Cys Met Ile Val Ile Phe 
625                 630                 635                 640 


Leu Thr Ile Ala Tyr Leu Lys Leu Leu Phe Leu Lys Lys Tyr Ser 
                645                 650                 655 


<210>  407
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  The sequence may be repeated n times, where n is an integer of at
       least one

<400>  407

Gly Ser Gly Gly Ser 
1               5   


<210>  408
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  The sequence may be repeated n times, where n is an integer of at
       least one

<400>  408

Gly Gly Gly Ser 
1               


<210>  409
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  409

Gly Gly Ser Gly 
1               


<210>  410
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  410

Gly Gly Ser Gly Gly 
1               5   


<210>  411
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  411

Gly Ser Gly Ser Gly 
1               5   


<210>  412
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  412

Gly Ser Gly Gly Gly 
1               5   


<210>  413
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  413

Gly Gly Gly Ser Gly 
1               5   


<210>  414
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  414

Gly Ser Ser Ser Gly 
1               5   


<210>  415
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  415

Glu Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Asp 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Ala Ile Ser Ser Gly Gly Ser Thr Tyr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Glu Asp Thr Ala Ile Tyr Phe Cys Thr 
                85                  90                  95      


Arg Asp Thr Tyr Tyr Gly Tyr Asn Gln Ile Pro Phe Val Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  416
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  416

Asp Ile Val Ile Ile Gln Ser Pro Pro Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Ile Ser Cys Gln Ala Ser Gln Asn Ile His Arg Tyr 
            20                  25                  30          


Ile Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Arg Tyr Thr Ser Thr Leu Glu Ser Gly Thr Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Arg Asp Tyr Ser Phe Ser Ile Ser Asn Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Ser Tyr Tyr Cys Leu Gln Tyr Val Asn Leu Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  417
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  417

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Ala Glu Ile Lys 
            100                 105         


<210>  418
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (57)..(57)
<223>  The amino acid at position 57 is Asn, Gln or Ser

<400>  418

Glu Val Lys Val Val Glu Ser Gly Gly Val Leu Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Xaa Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Met Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Ala Gly Asp Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser 
        115             


<210>  419
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  419

Gly Phe Thr Phe Ser Arg Tyr Thr Met Ser 
1               5                   10  


<210>  420
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (3)..(10)
<223>  The amino acids at positions 3 to 10 may independently either be 
       present or absent

<400>  420

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10  


