               LISTA DE SECUENCIAS

<110> INSTITUTO NACIONAL DE INVESTIGACIÓN Y TECNOLOGÍA AGRARIA Y ALIMENTARIA (INIA)

<120> VARIANTE ATENUADA DEL VIRUS DE LA FIEBRE DEL VALLE DEL RIFT, COMPOSICIÓN QUE LA COMPRENDE Y USOS DE LA MISMA

<130> PCT-08604

<150> ES202030529
<151> 2020-06-04

<160> 57

<170> BiSSAP 1.3.6

<210> 1
<211> 6404
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Segmento L virus VFVR FMH-P8

<220> 
<221> gen
<222> 19..6297
<223> /note="Marco abierto de lectura del segmento L virus VFVR FMH-P8"

<400> 1
acacaaaggc gcccaatcat ggattctata ttatcaaaac agctggttga caagactggt       60

tttgttagag tgccaatcaa gcattatgac tgtacaatgc taactctggc actcccaaca      120

tttgatgtct ccaagatggt agatagaatt accatagact tcaatttaga cgacatacaa      180

ggagcatctg aaataggttc aactttgcta ccctctatgt cgatagatgt ggaagatatg      240

gccaattttg ttcacgattt cacctttggc cacttagctg acaagactga cagactctta      300

atgcgtgagt ttcccacgat gaatgacggg tttgatcatc tgagccctga catgattatc      360

aaaactacat ctggcatgta taacatcgtt gagtttacca cctttagggg ggatgaaaga      420

ggtgcattcc aggctgccat gactaaactc gctaagtatg aggttccttg tgagaacaga      480

tctcagggca ggactgttgt tctttatgtt gttagcgcct accggcatgg tgtttggtct      540

aatttggagc tagaggactc tgaagcagag gagatggtat ataggtacag acttgccctt      600

agtgtgatgg atgagctaag gaccttgttc ccagaactgt catccacaga tgaggaacta      660

ggaaagactg agagagagtt gctagccatg gtctcctcca tccaaataaa ttggtcagtc      720

acagaatctg tgtttcctcc ctttagcaga gaaatgtttg acaggttcag atcttctcct      780

cccgattcag agtacatcac gaggatagtg agcagatgcc tcataaattc tcaagagaaa      840

ctcatcaata attccttctt tgctgaaggg aatgataaag ttttgagatt ttcaaaaaac      900

gctgaggagt gttccttggc aatagagaga gctttaaatc agtatagggc agaagacaac      960

cttagggacc tcaatgacca caagtctact attcagctgc ccccctggct gtcctatcac     1020

gatgccgatg gcaaagatct gtgccctctt cagggattag atgtgagagg agaccatccc     1080

atgtgcaacc tgtggagaga agtggttacc tctgcaaatt tagaggagat tgagaggatg     1140

tacgatgatg cagcggcaga acttgagttt gccctttcag gggtgaagga caggccagat     1200

gaaagaaaca gataccatag agtccatctg aatatggact cagatgatag tgtctacata     1260

gctgctttag gggttaatgg aaagaagcat aaagcagaca cattagtgca acaaatgaga     1320

gacaggagca aacagccctt ctctccagat catgatgtgg atcacatatc tgaatttctc     1380

tctgcatgct ctagtgactt gtgggcaaca gatgaggacc tatacaaccc tctctcttgt     1440

gataaagagc ttagattggc agctcagaga attcatcagc catccttatc agaaaggggc     1500

ttcaatgaga ttataacaga gcactacaga tttatgggaa gtaggatagg atcatggtgc     1560

caaatggtca gtttaatagg agctgagcta tcagcttctg taaagcaaca tgttaagcct     1620

aactattttg tgattaaacg actactaggt tctgggattt tcttgctgat caagcctact     1680

tccagcaaaa gccatatatt cgtgtctttt gcaattaagc gctcttgctg ggcctttgat     1740

ctctccactt ccagggtttt caaaccctac atagatgccg gggatctgtt agttactgac     1800

tttgtttctt acaaactaag taagcttacc aacctctgca agtgcgtttc gttaatggaa     1860

tcctccttct cattttgggc agaggcattt gggattccaa gctggaactt tgttagtgac     1920

ttgttcaggt cttcagactc tgcagcaatg gatgcctcat acatgggcaa actctcttta     1980

ttaacccttt tggaagacaa agcaacaact gaagagttac agactattgc aagatatata     2040

atcatggagg gctttgtctc gcccccagaa atcccaaaac ctcacaagat gacctctaag     2100

tttcccaagg ttctcaggtc agagctgcag gtttacttat taaactgctt atgcagaact     2160

atccagagaa tagcaggtga gccctttatt cttaagaaga aggatgggtc tatatcctgg     2220

ggtggcatgt ttaatccttt ttcagggcgt ccactgcttg atatgcaacc actcatcagc     2280

tgttgttaca atggttactt taaaaacaaa gaagaagaga ctgagccttc ctccctttct     2340

gggatgtata agaaaattat agaacttgag caccttagac cacagtcaga tgccttcttg     2400

ggttataaag atccagaact acctagaatg catgagttca gtgtttccta cttgaaggag     2460

gcttgcaatc atgctaagct ggtcttaagg agtctctatg gacagaattt catggagcaa     2520

atagacaacc aaattattcg agagctcagt gggttgactc tagaaagatt agccacactt     2580

aaggccacaa gcaactttaa tgagaattgg tatgtctata aggatgtggc agacaagaac     2640

tacacaaggg ataaattatt agtgaagatg tcaaaatatg cttctgaggg aaagagccta     2700

gctatccaga agtttgagga ttgcatgagg cagatagagt cacaaggatg tatgcatatt     2760

tgtttgttta agaaacaaca gcatggaagt ctgagagaga tctatgtgat gggtgcagag     2820

gaaagaattg ttcaatcggt ggtggagaca atagccaggt ctatagggaa gttctttgct     2880

tctgataccc tctgtaaccc ccccaataag gtgaaaattc ctgagacaca tggcattagg     2940

gctcggaagc aatgtaaggg gcctgtgtgg acttgtgcaa catcagatga tgcaaggaag     3000

tggaaccaag gccattttgt tacaaagttt gccctcatgc tatgtgagtt cacctctcct     3060

aagtggtggc cattgatcat taggggatgt tcaatgttta ccaggaaaag gatgatgatg     3120

aatttgaatt atcttaagat cctggatggt catcgagagc ttgatgttag agatgacttt     3180

gtgatggatc tcttcaaagc ttatcatggt gaggcagaag ttccatgggc ttttaagggt     3240

aaaacatatc tggaaaccac aacagggatg atgcagggga tattgcatta tacttcctca     3300

ttattacaca ccattcatca agaatacatc cggtccttgt cctttaaaat attcaacctg     3360

aaggttgctc ctgagatgag caaaagcctg gtttgtgaca tgatgcaagg atcagatgat     3420

agtagcatgc taatcagctt cccagctgat gacgagaagg ttctcaccag atgcaaagtg     3480

gccgcagcca tatgcttccg aatgaagaag gagctgggag tgtaccttgc catctacccc     3540

tcagagaagt ccacagcaaa cacagatttt gtgatggagt acaattctga attttatttc     3600

cacacccagc atgttagacc gacgatcagg tggattgcag catgttgcag cctgccagaa     3660

gtggaaacac tagtagcccg ccaggaagag gcctctaatc taatgacttc agttactgag     3720

gggggtgggt cattctcctt agctgcaatg attcagcaag ctcagtgcac tctccattac     3780

atgctaatgg gcatgggagt gtctgagcta ttcttagagt ataagaaggc agtgctgaag     3840

tggaatgacc ctggtctggg tttcttcctg cttgacaatc cttatgcgtg cgggttggga     3900

ggttttagat ttaatctctt caaaaccatc accagaactg atttgcagaa gctatatgct     3960

ttcttcatga agaaggttaa gggctcagct gctagggact gggcagatga ggatgttacc     4020

atcccagaaa cgtgtagcgt gagcccaggt ggcgctctaa ttcttagctc ctctctaaag     4080

tggggatcta ggaagaagtt tcagaaacta agagaccgtt tgaacatacc agagaactgg     4140

attgagctaa taaatgagaa tccagaggtg ctctatcgag ctcccagaac aggcccagaa     4200

atattgttgc gcattgcaga gaaagtccat agccctggtg ttgtgtcatc attgtcttct     4260

ggcaatgcag tctgtaaagt catggcctca gctgtatact tcttatcagc aacaattttt     4320

gaagacactg gacgccctga gttcaacttc ttagaggatt ccaagtacag cttgctacaa     4380

aagatggccg catattctgg ctttcatggt ttcaatgata tggagccaga agatatatta     4440

ttcctattcc cgaacattga ggaattagaa tcactggatt ctatagttta caacaaggga     4500

gaaatagaca tcatcccaag agttaatatc agggatgcaa cccaaaccag ggtcactatc     4560

tttaatgagc agaagaccct ccgaacatct ccagagaagt tggtgtcaga caagtggttc     4620

gggactcaga agagtaggat aggcaaaaca actttcctgg ctgaatggga gaagctaaag     4680

aaaattgtga agtggttgga agacactcca gaagcaactc tagctcacac tccactgaat     4740

aaccatattc aggttaggaa tttctttgct agaatggaaa gcaagcctag aacggttaga     4800

ataacaggag ctcctgtaaa gaagaggtca ggggttagca agatagctat ggttatccgt     4860

gacaatttct cccggatggg ccatcttaga ggtgtagaag acttcgctgg cttcactcgt     4920

agtgtgtcag ctgaaatcct caagcacttt ctgttctgca tactacaggg tccatacagt     4980

gagagctata aactacagct aatctacaga gtcctaagct cagtatcaaa cgttgagata     5040

aaggaatcgg atggtaagac aaaaaccaat ttgattggga tccttcagag atttctagat     5100

ggtgatcacg ttgtccctat aattgaagag atgggagccg gaacagtggg tggattcatc     5160

aagagacaac agtctaaagt tgtgcaaaat aaggtggtct attatggagt tgggatctgg     5220

agaggcttta tggatggata tcaggtccat cttgagatag aaaatgacat aggacagccc     5280

ccaaggctta ggaatgtcac aactaactgt cagagcagcc catgggatct gagtgtccca     5340

ataaggcagt gggcagaaga catgggggtc acaaacaacc aggattattc ctctaaatct     5400

agcagaggag ctagatattg gatgcattca tttaggatgc aaggacccag caagccattt     5460

ggatgcccag tttatattat taagggtgac atgtcagatg ttatcagact gagaaaagag     5520

gaggtggaga tgaaagtacg gggctctact ctcaacttgt acactaagca ccattctcat     5580

caagacttac acattttatc ttacactgca tcagacaatg atctcagtcc aggcattttc     5640

aagtcaatat cagatgaggg agtggctcaa gccctgcagt tatttgagag ggagccaagc     5700

aactgctggg tgagatgtga gtctgtagct ccaaaattca tatcagccat ccttgagata     5760

tgtgagggga agagacagat aaaaggaatc aacagaacca gactctcaga gattgtgaga     5820

atttgttctg aatcttccct aagatcaaag gtcggatcta tgttctcatt tgtcgccaat     5880

gttgaggagg cccatgatgt tgattatgat gcgttaatgg atctaatgat agaagatgct     5940

aagaacaatg cattcagtca tgttgtcgat tgcatagagt tggatgttaa tggtccttac     6000

gagatggagt cttttgatac atctgatgtc aacctctttg ggccagccca ttacaaggac     6060

atcagttcat tatctatgat tgctcatccc ttaatggata agtttgttga ttatgccatt     6120

tccaagatgg ggagagcctc agttagaaaa gttctagaga caggtcggtg ctctagcaaa     6180

gactatgatt tatcaaaggt tctcttcaga actctacaga gaccagaaaa gagcattagg     6240

atagatgatc tggagttata tgaggagaca gatgtggcgg atgacatgct aggctaagac     6300

caataagcaa agtcaggctt agatttaggg atactacgct agtattggaa tccatgtggg     6360

ttctgatact agcatagtgc tacaatattg ggcggtcttt gtgt                      6404


<210> 2
<211> 3885
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Segmento M virus VFVR FMH-P8

<220> 
<221> gen
<222> 21..3614
<223> /note="Gen que codifica para (poli)proteína M virus VFVR FMH-P8"

<400> 2
acacaaagac ggtgcattaa atgtatgttt tactaacaat tctgatcacg gttctggtgt       60

gtgaagcggt tattagagtg tctctaagct ccacaaaaga agagacctgt tttggtgact      120

ccaccaaccc agagatgatt gaaggagctt gggattcact cagagaggag gagatgccag      180

aggagctctc ctgttctata tcaggcataa gggaggttaa gacctcaagc caggagttat      240

acagggcatt aaaagccatc attgctgctg atggcttgaa caacatcacc tgccatggta      300

aggatcctga ggacaagatt tctctcataa agggtcctcc ttacaaaaag cgggtgggga      360

tagttcggtg taaaagacga agagatgcta agcaaatagg gagagaaacc atggcaggga      420

ttgcaatgac agtccttcca gccttagcag tttttgcttt ggcacctgtt gtttttgctg      480

aagaccccca tctcaggaac agaccaggga aggggcacaa ctacattgac gggatgactc      540

aggaggatgc cacatgcaaa cctgtgacat atgctggggc atgtagcagt tttgatgtct      600

tgcttgaaaa ggggaaattt ccccttttcc agtcgtatgc tcatcataaa actctactgg      660

aagcagttca cgacactatc attgcaaagg ctgatccacc tagctgtgac cttcaaagtg      720

ctcatgggaa tccctgcatg aaagagaaac tcgtgatgaa gacacactgt ccaaatgact      780

accagtcagc tcattacctc aacaatgacg ggaaagtggc ttcagtcaag tgccctccta      840

agtatgagct cactgaggac tgcaactttt gtaggcagat gacaggtgct agcctgaaga      900

aagggtctta tcctctccaa gacttatttt gtcagtcaag tgaggatgat ggatcaaaat      960

taaaaacaaa aatgaaaggg gtctgcgaag tgggggttca agcactcaaa aagtgtaatg     1020

gccaactcag cactgcacat gaggttgtgc cctttgcagt gtttaagaac tcaaagaaag     1080

tttatcttga taagcttgac ctcaaaactg aggagaatct gctaccagac tcatttgtct     1140

gcttcgagca taagggacag tataaaggaa caatggactc tggtcagact aagagggagc     1200

tcaaaagctc tgatatctct cagtgcccca agattggagg acatggtagt aaaaagtgca     1260

ctggggacgc agcattttgc tctgcttatg agtgcactac tcagtacgcc aatgtctact     1320

gttcacatgc taatggatca gggattgtgc agatacaagt atcaggggtc tggaagaagc     1380

ctttatgtgt agggtatgag agagtggttg tgaagagaga actctctgcc aagcccatcc     1440

agagagttga gccctgcaca acttgtataa ccaaatgtgg gcctcatgga ttggttgtcc     1500

gatcaacagg gttcaagata tcatctgcag ttgcttgtgc tagcggagtt tgcgtcacag     1560

gatcgcagag tccttctacc gagattacac tcaagtatcc agggatatcc cagtcctctg     1620

ggggggacat aggggtttac atggcacatg atgatcagtc agttagctcc aaaatagtag     1680

ctcactgccc cccccaggac ccgtgcttag tgcatggctg catagtgtgt gctcatggcc     1740

taataaatta ccagtgtcac actactctca gtgcctttat tgttgtgttt gtattcagtt     1800

ctattgcaat aacttgttta gctattcttt atagggtgct caagtgccta aagattgccc     1860

caaggaaggt tctaaatcca ctaatgtgga ttacagcctt catcagatgg gtgtataaga     1920

agatggttgc tagagtggca gacaatatta atcaagtgaa cagggaaata ggatggatgg     1980

aagggggtca gttggttcta gggaaccctg cccctattcc tcgtcatgcc ccaatcccac     2040

gttatagcac atacctaatg ctactattga ttgtctcata tgcatcagca tgttcagaac     2100

tgattcaggc aagctccaga atcaccactt gctccacaga gggtgttaac accaagtgta     2160

gactgtctgg cacagcattg atcagggcag ggtcagttgg ggcagaggct tgtttaatgt     2220

tgaagggggt caaggaagat caaaccaaat tcttgaagat aaaaactgtc tcaagtgagc     2280

tatcgtgcag ggagggccag agctattgga ctgggtcctt tagtcccaaa tgtctgagct     2340

caaggagatg ccatcttgtt ggagaatgtc atgtgaatag gtgtctgtct tggagggaca     2400

atgaaacttc agcagagttt tcatttgttg gggaaagcac gaccatgcga gagaataagt     2460

gttttgagca gtgtggagga tgggggtgtg ggtgcttcaa tgtgaaccca tcttgcttat     2520

ttgtgcacac gtacctgcag tcagttagaa aagaggccct tagagttttt aactgtatcg     2580

actgggtgca taaactcagt ctagagatca cagactttga tggctctgtt tcaacaatag     2640

acttgggagc atcatctagc cgtttcacaa actggggttc agttagcctc tcactggacg     2700

cagagggtat ttcaggctca aatagctttt ctttcattga gagcccaggc aaagggtatg     2760

caattgttga tgagccattc tcagaaattc ctcggcaagg gttcttgggg gagatcaggt     2820

gtaattcaga gtcctcagtc ctgagtgctc atgaatcatg ccttagggta ccaaacctta     2880

tctcatacaa gcccatgata gatcaattgg agtgcacaac aaatctgatt gatccttttg     2940

ttgtctttga gaggggttct ctgccacaga caaggaatga aaaaaccttt gcagcttcaa     3000

aaggaaatag gggtgttcaa gctttctcta agggctctgt acaagctgat ctaactctga     3060

tgtttgacaa ttttgaggtg gactttgtgg gagcagccgt atcttgtgat gccgccttct     3120

taaacttgac aggttgctat tcttgcaatg cgggagccag ggtctgcctg tctatcacat     3180

ccacaggaac tggaactctc tctgcccaca ataaggatgg gtctctgcac atagttcttc     3240

catcagagaa tggaacaaaa gatcagtgtc agatactaca cttcactata cctgaagtag     3300

aggaggagtt tatgtactct tgtgatggag atgagcggcc tctgttggtg aaagggactc     3360

tgatagttat tgatccattt gatgataggc gggaagcagg gggggaatca acagttgtga     3420

atccaaaatc tggatcttgg aatttctttg actggttttc tggactcatg agttggtttg     3480

gagggcctct taaaactata ctcctcattt gcctgtatgt tgcattatca attgggctct     3540

ttttcctcct tatatatctt ggaaaaacag gcctctctaa aatgtggctt gctgctacta     3600

agaaggcctc atagatcagt acgtgtagaa gcaatatgta gaaacaagtg gacataagca     3660

aacctaatta tgtaaatatt gtacagatag gtcaaattat tgggatatcc aagcttagat     3720

gcttatgcaa tattactttt gatgtaagct tagttgtaat ttggggtggt ggggtgaggc     3780

agcagcagtc tcaagtgctt gtgaatattc tagttggcgt gaatgtcttt tgccagatta     3840

gctgggaatt aaactaactc tttgaagttg caccggtctt tgtgt                     3885


<210> 3
<211> 1691
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Segmento S virus VFVR FMH-P8

<220> 
<221> gen
<222> 35..832
<223> /note="Gen que codifica para proteína NSs virus VFVR FMH-P8"

<220> 
<221> gen
<222> 916..1653
<223> /note="Gen que codifica para proteína N virus VFVR FMH-P8
      (complementario)"

<400> 3
acacaaagac cccctagtgc ttatcaagtg tatcatggat tactttcctg tgatatctgt      60

tgatttgcag agtggtcgtc gtgttgtgtc agtggagtac attagaggtg atggtcctcc     120

cagaatacct tattctatgg ttgggccctg ttgtgtcttt ctcatgcacc atcgtcctag     180

tcacgagatt cgcttgcgat tctctgattt ctacaatgtc ggagaattcc cataccgagt     240

cggacttgga gactttgtat caaacgttgc acctccacta gcaaagcctt ttcagagact     300

tattgatcta ataggccata tgactcttag tgatttcaca aggttcccca atctgaaaga     360

agccatatcc tggcctcttg gagaaccctc cctggctttc tttgacctaa gctccaccag     420

agtgcatagg tctgatgata ttagaaggga ccagattgct actctagcaa tgaggagctg     480

caagattacc aatgatctgg aggactcctt tgttggctta cacaggatga tagtgaccga     540

ggctatcctc agagggattg acttgtgcct gttgccaggc tttgatctca tgtatgaagt     600

tgctcacgtt cagtgtgttc ggctcctgca ggcagcaaga gaggatattt ctaatgctgt     660

agttccaaac tcagctctca ttgctcttat ggaggagagc ttgatgctgc gctcatcact     720

ccctagcatg atggggagaa acaactgggt tccagttgtt cctccaatcc cagatgttga     780

gatagaatca gaggaagaga gtgatgacga tggatttgtt gaggttgatt agagattaag     840

gctgccccac cccccacccc caatcccgac cgtaacccca accacctcct tttccccaaa     900

cccctgggca gccacttagg ctgctgtctt gtacgcctga gcagctgcca taacagctgc     960

tgacggcttc ccattggaat ccacaagccc aaaagctttc aagaattctc tcctcttctc    1020

atggcttata aagttgctat tcactgctgc attcattggc tgcgtgaacg ttgcggcaac    1080

ctcctccttt gttctacctc ggaggtttgg gttgatgacc cgggagaact gcagcagata    1140

cagagagtga gcatccaata ttgcccttag atagtcttct ggtagagaag ggtccaccat    1200

gccagcaaag ctggggtgca tcatatgcct tgggtatgca ggggataggc catccatggt    1260

ggtcccagtg acaggaagcc actcactcaa gacgaccaaa gcctggcaag tccagccagc    1320

cagggcagca gcaactcgtg atagagtcaa ctcatcccgg gaaggattcc cctcctttag    1380

cttatacttg ttgatgagag cctccacagt tgctttgcct tctttcgaca ttttcatcat    1440

catcctccgg ggcttgttgc cacgagtcag agccagaaca atcattttct tggcatcctt    1500

ctcccagcca gccccaccat actgctttaa gagttcgata accctacggg catcaaatcc    1560

ttgataagca aactctcgga cccactgttc aatctcattg cggtccactg cttgagcagc    1620

aaactggatc gcaagctctt gataattgtc cattattgta atagtgtttg tatctctagg    1680

gagctttgtg t                                                         1691


<210> 4
<211> 2092
<212> PRT
<213> Secuencia Artificial


<220> 
<223> Proteína L virus VFVR FMH-P8

<220> 
<221> MUTAGEN
<222> 100
<223> Thr

<220> 
<221> MUTAGEN
<222> 375
<223> Tyr

<220> 
<221> MUTAGEN
<222> 924
<223> Ser

<220> 
<221> MUTAGEN
<222> 1050
<223> Val

<220> 
<221> MUTAGEN
<222> 1303
<223> Thr

<220> 
<221> MUTAGEN
<222> 1629
<223> Phe

<220> 
<221> MUTAGEN
<222> 2071
<223> Lys

<400> 4
Met Asp Ser Ile Leu Ser Lys Gln Leu Val Asp Lys Thr Gly Phe Val 
1               5                   10                  15      
Arg Val Pro Ile Lys His Tyr Asp Cys Thr Met Leu Thr Leu Ala Leu 
            20                  25                  30          
Pro Thr Phe Asp Val Ser Lys Met Val Asp Arg Ile Thr Ile Asp Phe 
        35                  40                  45              
Asn Leu Asp Asp Ile Gln Gly Ala Ser Glu Ile Gly Ser Thr Leu Leu 
    50                  55                  60                  
Pro Ser Met Ser Ile Asp Val Glu Asp Met Ala Asn Phe Val His Asp 
65                  70                  75                  80  
Phe Thr Phe Gly His Leu Ala Asp Lys Thr Asp Arg Leu Leu Met Arg 
                85                  90                  95      
Glu Phe Pro Thr Met Asn Asp Gly Phe Asp His Leu Ser Pro Asp Met 
            100                 105                 110         
Ile Ile Lys Thr Thr Ser Gly Met Tyr Asn Ile Val Glu Phe Thr Thr 
        115                 120                 125             
Phe Arg Gly Asp Glu Arg Gly Ala Phe Gln Ala Ala Met Thr Lys Leu 
    130                 135                 140                 
Ala Lys Tyr Glu Val Pro Cys Glu Asn Arg Ser Gln Gly Arg Thr Val 
145                 150                 155                 160 
Val Leu Tyr Val Val Ser Ala Tyr Arg His Gly Val Trp Ser Asn Leu 
                165                 170                 175     
Glu Leu Glu Asp Ser Glu Ala Glu Glu Met Val Tyr Arg Tyr Arg Leu 
            180                 185                 190         
Ala Leu Ser Val Met Asp Glu Leu Arg Thr Leu Phe Pro Glu Leu Ser 
        195                 200                 205             
Ser Thr Asp Glu Glu Leu Gly Lys Thr Glu Arg Glu Leu Leu Ala Met 
    210                 215                 220                 
Val Ser Ser Ile Gln Ile Asn Trp Ser Val Thr Glu Ser Val Phe Pro 
225                 230                 235                 240 
Pro Phe Ser Arg Glu Met Phe Asp Arg Phe Arg Ser Ser Pro Pro Asp 
                245                 250                 255     
Ser Glu Tyr Ile Thr Arg Ile Val Ser Arg Cys Leu Ile Asn Ser Gln 
            260                 265                 270         
Glu Lys Leu Ile Asn Asn Ser Phe Phe Ala Glu Gly Asn Asp Lys Val 
        275                 280                 285             
Leu Arg Phe Ser Lys Asn Ala Glu Glu Cys Ser Leu Ala Ile Glu Arg 
    290                 295                 300                 
Ala Leu Asn Gln Tyr Arg Ala Glu Asp Asn Leu Arg Asp Leu Asn Asp 
305                 310                 315                 320 
His Lys Ser Thr Ile Gln Leu Pro Pro Trp Leu Ser Tyr His Asp Ala 
                325                 330                 335     
Asp Gly Lys Asp Leu Cys Pro Leu Gln Gly Leu Asp Val Arg Gly Asp 
            340                 345                 350         
His Pro Met Cys Asn Leu Trp Arg Glu Val Val Thr Ser Ala Asn Leu 
        355                 360                 365             
Glu Glu Ile Glu Arg Met Tyr Asp Asp Ala Ala Ala Glu Leu Glu Phe 
    370                 375                 380                 
Ala Leu Ser Gly Val Lys Asp Arg Pro Asp Glu Arg Asn Arg Tyr His 
385                 390                 395                 400 
Arg Val His Leu Asn Met Asp Ser Asp Asp Ser Val Tyr Ile Ala Ala 
                405                 410                 415     
Leu Gly Val Asn Gly Lys Lys His Lys Ala Asp Thr Leu Val Gln Gln 
            420                 425                 430         
Met Arg Asp Arg Ser Lys Gln Pro Phe Ser Pro Asp His Asp Val Asp 
        435                 440                 445             
His Ile Ser Glu Phe Leu Ser Ala Cys Ser Ser Asp Leu Trp Ala Thr 
    450                 455                 460                 
Asp Glu Asp Leu Tyr Asn Pro Leu Ser Cys Asp Lys Glu Leu Arg Leu 
465                 470                 475                 480 
Ala Ala Gln Arg Ile His Gln Pro Ser Leu Ser Glu Arg Gly Phe Asn 
                485                 490                 495     
Glu Ile Ile Thr Glu His Tyr Arg Phe Met Gly Ser Arg Ile Gly Ser 
            500                 505                 510         
Trp Cys Gln Met Val Ser Leu Ile Gly Ala Glu Leu Ser Ala Ser Val 
        515                 520                 525             
Lys Gln His Val Lys Pro Asn Tyr Phe Val Ile Lys Arg Leu Leu Gly 
    530                 535                 540                 
Ser Gly Ile Phe Leu Leu Ile Lys Pro Thr Ser Ser Lys Ser His Ile 
545                 550                 555                 560 
Phe Val Ser Phe Ala Ile Lys Arg Ser Cys Trp Ala Phe Asp Leu Ser 
                565                 570                 575     
Thr Ser Arg Val Phe Lys Pro Tyr Ile Asp Ala Gly Asp Leu Leu Val 
            580                 585                 590         
Thr Asp Phe Val Ser Tyr Lys Leu Ser Lys Leu Thr Asn Leu Cys Lys 
        595                 600                 605             
Cys Val Ser Leu Met Glu Ser Ser Phe Ser Phe Trp Ala Glu Ala Phe 
    610                 615                 620                 
Gly Ile Pro Ser Trp Asn Phe Val Ser Asp Leu Phe Arg Ser Ser Asp 
625                 630                 635                 640 
Ser Ala Ala Met Asp Ala Ser Tyr Met Gly Lys Leu Ser Leu Leu Thr 
                645                 650                 655     
Leu Leu Glu Asp Lys Ala Thr Thr Glu Glu Leu Gln Thr Ile Ala Arg 
            660                 665                 670         
Tyr Ile Ile Met Glu Gly Phe Val Ser Pro Pro Glu Ile Pro Lys Pro 
        675                 680                 685             
His Lys Met Thr Ser Lys Phe Pro Lys Val Leu Arg Ser Glu Leu Gln 
    690                 695                 700                 
Val Tyr Leu Leu Asn Cys Leu Cys Arg Thr Ile Gln Arg Ile Ala Gly 
705                 710                 715                 720 
Glu Pro Phe Ile Leu Lys Lys Lys Asp Gly Ser Ile Ser Trp Gly Gly 
                725                 730                 735     
Met Phe Asn Pro Phe Ser Gly Arg Pro Leu Leu Asp Met Gln Pro Leu 
            740                 745                 750         
Ile Ser Cys Cys Tyr Asn Gly Tyr Phe Lys Asn Lys Glu Glu Glu Thr 
        755                 760                 765             
Glu Pro Ser Ser Leu Ser Gly Met Tyr Lys Lys Ile Ile Glu Leu Glu 
    770                 775                 780                 
His Leu Arg Pro Gln Ser Asp Ala Phe Leu Gly Tyr Lys Asp Pro Glu 
785                 790                 795                 800 
Leu Pro Arg Met His Glu Phe Ser Val Ser Tyr Leu Lys Glu Ala Cys 
                805                 810                 815     
Asn His Ala Lys Leu Val Leu Arg Ser Leu Tyr Gly Gln Asn Phe Met 
            820                 825                 830         
Glu Gln Ile Asp Asn Gln Ile Ile Arg Glu Leu Ser Gly Leu Thr Leu 
        835                 840                 845             
Glu Arg Leu Ala Thr Leu Lys Ala Thr Ser Asn Phe Asn Glu Asn Trp 
    850                 855                 860                 
Tyr Val Tyr Lys Asp Val Ala Asp Lys Asn Tyr Thr Arg Asp Lys Leu 
865                 870                 875                 880 
Leu Val Lys Met Ser Lys Tyr Ala Ser Glu Gly Lys Ser Leu Ala Ile 
                885                 890                 895     
Gln Lys Phe Glu Asp Cys Met Arg Gln Ile Glu Ser Gln Gly Cys Met 
            900                 905                 910         
His Ile Cys Leu Phe Lys Lys Gln Gln His Gly Ser Leu Arg Glu Ile 
        915                 920                 925             
Tyr Val Met Gly Ala Glu Glu Arg Ile Val Gln Ser Val Val Glu Thr 
    930                 935                 940                 
Ile Ala Arg Ser Ile Gly Lys Phe Phe Ala Ser Asp Thr Leu Cys Asn 
945                 950                 955                 960 
Pro Pro Asn Lys Val Lys Ile Pro Glu Thr His Gly Ile Arg Ala Arg 
                965                 970                 975     
Lys Gln Cys Lys Gly Pro Val Trp Thr Cys Ala Thr Ser Asp Asp Ala 
            980                 985                 990         
Arg Lys Trp Asn Gln Gly His Phe Val Thr Lys Phe Ala Leu Met Leu 
        995                 1000                1005            
Cys Glu Phe Thr Ser Pro Lys Trp Trp Pro Leu Ile Ile Arg Gly Cys 
    1010                1015                1020                
Ser Met Phe Thr Arg Lys Arg Met Met Met Asn Leu Asn Tyr Leu Lys 
1025                1030                1035                1040
Ile Leu Asp Gly His Arg Glu Leu Asp Val Arg Asp Asp Phe Val Met 
                1045                1050                1055    
Asp Leu Phe Lys Ala Tyr His Gly Glu Ala Glu Val Pro Trp Ala Phe 
            1060                1065                1070        
Lys Gly Lys Thr Tyr Leu Glu Thr Thr Thr Gly Met Met Gln Gly Ile 
        1075                1080                1085            
Leu His Tyr Thr Ser Ser Leu Leu His Thr Ile His Gln Glu Tyr Ile 
    1090                1095                1100                
Arg Ser Leu Ser Phe Lys Ile Phe Asn Leu Lys Val Ala Pro Glu Met 
1105                1110                1115                1120
Ser Lys Ser Leu Val Cys Asp Met Met Gln Gly Ser Asp Asp Ser Ser 
                1125                1130                1135    
Met Leu Ile Ser Phe Pro Ala Asp Asp Glu Lys Val Leu Thr Arg Cys 
            1140                1145                1150        
Lys Val Ala Ala Ala Ile Cys Phe Arg Met Lys Lys Glu Leu Gly Val 
        1155                1160                1165            
Tyr Leu Ala Ile Tyr Pro Ser Glu Lys Ser Thr Ala Asn Thr Asp Phe 
    1170                1175                1180                
Val Met Glu Tyr Asn Ser Glu Phe Tyr Phe His Thr Gln His Val Arg 
1185                1190                1195                1200
Pro Thr Ile Arg Trp Ile Ala Ala Cys Cys Ser Leu Pro Glu Val Glu 
                1205                1210                1215    
Thr Leu Val Ala Arg Gln Glu Glu Ala Ser Asn Leu Met Thr Ser Val 
            1220                1225                1230        
Thr Glu Gly Gly Gly Ser Phe Ser Leu Ala Ala Met Ile Gln Gln Ala 
        1235                1240                1245            
Gln Cys Thr Leu His Tyr Met Leu Met Gly Met Gly Val Ser Glu Leu 
    1250                1255                1260                
Phe Leu Glu Tyr Lys Lys Ala Val Leu Lys Trp Asn Asp Pro Gly Leu 
1265                1270                1275                1280
Gly Phe Phe Leu Leu Asp Asn Pro Tyr Ala Cys Gly Leu Gly Gly Phe 
                1285                1290                1295    
Arg Phe Asn Leu Phe Lys Thr Ile Thr Arg Thr Asp Leu Gln Lys Leu 
            1300                1305                1310        
Tyr Ala Phe Phe Met Lys Lys Val Lys Gly Ser Ala Ala Arg Asp Trp 
        1315                1320                1325            
Ala Asp Glu Asp Val Thr Ile Pro Glu Thr Cys Ser Val Ser Pro Gly 
    1330                1335                1340                
Gly Ala Leu Ile Leu Ser Ser Ser Leu Lys Trp Gly Ser Arg Lys Lys 
1345                1350                1355                1360
Phe Gln Lys Leu Arg Asp Arg Leu Asn Ile Pro Glu Asn Trp Ile Glu 
                1365                1370                1375    
Leu Ile Asn Glu Asn Pro Glu Val Leu Tyr Arg Ala Pro Arg Thr Gly 
            1380                1385                1390        
Pro Glu Ile Leu Leu Arg Ile Ala Glu Lys Val His Ser Pro Gly Val 
        1395                1400                1405            
Val Ser Ser Leu Ser Ser Gly Asn Ala Val Cys Lys Val Met Ala Ser 
    1410                1415                1420                
Ala Val Tyr Phe Leu Ser Ala Thr Ile Phe Glu Asp Thr Gly Arg Pro 
1425                1430                1435                1440
Glu Phe Asn Phe Leu Glu Asp Ser Lys Tyr Ser Leu Leu Gln Lys Met 
                1445                1450                1455    
Ala Ala Tyr Ser Gly Phe His Gly Phe Asn Asp Met Glu Pro Glu Asp 
            1460                1465                1470        
Ile Leu Phe Leu Phe Pro Asn Ile Glu Glu Leu Glu Ser Leu Asp Ser 
        1475                1480                1485            
Ile Val Tyr Asn Lys Gly Glu Ile Asp Ile Ile Pro Arg Val Asn Ile 
    1490                1495                1500                
Arg Asp Ala Thr Gln Thr Arg Val Thr Ile Phe Asn Glu Gln Lys Thr 
1505                1510                1515                1520
Leu Arg Thr Ser Pro Glu Lys Leu Val Ser Asp Lys Trp Phe Gly Thr 
                1525                1530                1535    
Gln Lys Ser Arg Ile Gly Lys Thr Thr Phe Leu Ala Glu Trp Glu Lys 
            1540                1545                1550        
Leu Lys Lys Ile Val Lys Trp Leu Glu Asp Thr Pro Glu Ala Thr Leu 
        1555                1560                1565            
Ala His Thr Pro Leu Asn Asn His Ile Gln Val Arg Asn Phe Phe Ala 
    1570                1575                1580                
Arg Met Glu Ser Lys Pro Arg Thr Val Arg Ile Thr Gly Ala Pro Val 
1585                1590                1595                1600
Lys Lys Arg Ser Gly Val Ser Lys Ile Ala Met Val Ile Arg Asp Asn 
                1605                1610                1615    
Phe Ser Arg Met Gly His Leu Arg Gly Val Glu Asp Phe Ala Gly Phe 
            1620                1625                1630        
Thr Arg Ser Val Ser Ala Glu Ile Leu Lys His Phe Leu Phe Cys Ile 
        1635                1640                1645            
Leu Gln Gly Pro Tyr Ser Glu Ser Tyr Lys Leu Gln Leu Ile Tyr Arg 
    1650                1655                1660                
Val Leu Ser Ser Val Ser Asn Val Glu Ile Lys Glu Ser Asp Gly Lys 
1665                1670                1675                1680
Thr Lys Thr Asn Leu Ile Gly Ile Leu Gln Arg Phe Leu Asp Gly Asp 
                1685                1690                1695    
His Val Val Pro Ile Ile Glu Glu Met Gly Ala Gly Thr Val Gly Gly 
            1700                1705                1710        
Phe Ile Lys Arg Gln Gln Ser Lys Val Val Gln Asn Lys Val Val Tyr 
        1715                1720                1725            
Tyr Gly Val Gly Ile Trp Arg Gly Phe Met Asp Gly Tyr Gln Val His 
    1730                1735                1740                
Leu Glu Ile Glu Asn Asp Ile Gly Gln Pro Pro Arg Leu Arg Asn Val 
1745                1750                1755                1760
Thr Thr Asn Cys Gln Ser Ser Pro Trp Asp Leu Ser Val Pro Ile Arg 
                1765                1770                1775    
Gln Trp Ala Glu Asp Met Gly Val Thr Asn Asn Gln Asp Tyr Ser Ser 
            1780                1785                1790        
Lys Ser Ser Arg Gly Ala Arg Tyr Trp Met His Ser Phe Arg Met Gln 
        1795                1800                1805            
Gly Pro Ser Lys Pro Phe Gly Cys Pro Val Tyr Ile Ile Lys Gly Asp 
    1810                1815                1820                
Met Ser Asp Val Ile Arg Leu Arg Lys Glu Glu Val Glu Met Lys Val 
1825                1830                1835                1840
Arg Gly Ser Thr Leu Asn Leu Tyr Thr Lys His His Ser His Gln Asp 
                1845                1850                1855    
Leu His Ile Leu Ser Tyr Thr Ala Ser Asp Asn Asp Leu Ser Pro Gly 
            1860                1865                1870        
Ile Phe Lys Ser Ile Ser Asp Glu Gly Val Ala Gln Ala Leu Gln Leu 
        1875                1880                1885            
Phe Glu Arg Glu Pro Ser Asn Cys Trp Val Arg Cys Glu Ser Val Ala 
    1890                1895                1900                
Pro Lys Phe Ile Ser Ala Ile Leu Glu Ile Cys Glu Gly Lys Arg Gln 
1905                1910                1915                1920
Ile Lys Gly Ile Asn Arg Thr Arg Leu Ser Glu Ile Val Arg Ile Cys 
                1925                1930                1935    
Ser Glu Ser Ser Leu Arg Ser Lys Val Gly Ser Met Phe Ser Phe Val 
            1940                1945                1950        
Ala Asn Val Glu Glu Ala His Asp Val Asp Tyr Asp Ala Leu Met Asp 
        1955                1960                1965            
Leu Met Ile Glu Asp Ala Lys Asn Asn Ala Phe Ser His Val Val Asp 
    1970                1975                1980                
Cys Ile Glu Leu Asp Val Asn Gly Pro Tyr Glu Met Glu Ser Phe Asp 
1985                1990                1995                2000
Thr Ser Asp Val Asn Leu Phe Gly Pro Ala His Tyr Lys Asp Ile Ser 
                2005                2010                2015    
Ser Leu Ser Met Ile Ala His Pro Leu Met Asp Lys Phe Val Asp Tyr 
            2020                2025                2030        
Ala Ile Ser Lys Met Gly Arg Ala Ser Val Arg Lys Val Leu Glu Thr 
        2035                2040                2045            
Gly Arg Cys Ser Ser Lys Asp Tyr Asp Leu Ser Lys Val Leu Phe Arg 
    2050                2055                2060                
Thr Leu Gln Arg Pro Glu Lys Ser Ile Arg Ile Asp Asp Leu Glu Leu 
2065                2070                2075                2080
Tyr Glu Glu Thr Asp Val Ala Asp Asp Met Leu Gly 
                2085                2090        

<210> 5
<211> 1197
<212> PRT
<213> Secuencia Artificial


<220> 
<223> (Poli)proteína M virus VFVR FMH-P8

<220> 
<221> MUTAGEN
<222> 26
<223> Lys

<220> 
<221> MUTAGEN
<222> 108
<223> Tyr

<220> 
<221> MUTAGEN
<222> 118
<223> Lys

<220> 
<221> MUTAGEN
<222> 210
<223> Lys

<220> 
<221> MUTAGEN
<222> 333
<223> Asn

<220> 
<221> MUTAGEN
<222> 427
<223> Thr

<220> 
<221> MUTAGEN
<222> 432
<223> Val

<220> 
<221> MUTAGEN
<222> 487
<223> Gly

<220> 
<221> MUTAGEN
<222> 540
<223> Tyr

<220> 
<221> MUTAGEN
<222> 582
<223> Thr

<220> 
<221> MUTAGEN
<222> 587
<223> Ile

<220> 
<221> MUTAGEN
<222> 950
<223> Val

<220> 
<221> MUTAGEN
<222> 1090
<223> Ile

<220> 
<221> MUTAGEN
<222> 1116
<223> Val

<220> 
<221> MUTAGEN
<222> 1182
<223> Lys

<400> 5
Met Tyr Val Leu Leu Thr Ile Leu Ile Thr Val Leu Val Cys Glu Ala 
1               5                   10                  15      
Val Ile Arg Val Ser Leu Ser Ser Thr Lys Glu Glu Thr Cys Phe Gly 
            20                  25                  30          
Asp Ser Thr Asn Pro Glu Met Ile Glu Gly Ala Trp Asp Ser Leu Arg 
        35                  40                  45              
Glu Glu Glu Met Pro Glu Glu Leu Ser Cys Ser Ile Ser Gly Ile Arg 
    50                  55                  60                  
Glu Val Lys Thr Ser Ser Gln Glu Leu Tyr Arg Ala Leu Lys Ala Ile 
65                  70                  75                  80  
Ile Ala Ala Asp Gly Leu Asn Asn Ile Thr Cys His Gly Lys Asp Pro 
                85                  90                  95      
Glu Asp Lys Ile Ser Leu Ile Lys Gly Pro Pro Tyr Lys Lys Arg Val 
            100                 105                 110         
Gly Ile Val Arg Cys Lys Arg Arg Arg Asp Ala Lys Gln Ile Gly Arg 
        115                 120                 125             
Glu Thr Met Ala Gly Ile Ala Met Thr Val Leu Pro Ala Leu Ala Val 
    130                 135                 140                 
Phe Ala Leu Ala Pro Val Val Phe Ala Glu Asp Pro His Leu Arg Asn 
145                 150                 155                 160 
Arg Pro Gly Lys Gly His Asn Tyr Ile Asp Gly Met Thr Gln Glu Asp 
                165                 170                 175     
Ala Thr Cys Lys Pro Val Thr Tyr Ala Gly Ala Cys Ser Ser Phe Asp 
            180                 185                 190         
Val Leu Leu Glu Lys Gly Lys Phe Pro Leu Phe Gln Ser Tyr Ala His 
        195                 200                 205             
His Lys Thr Leu Leu Glu Ala Val His Asp Thr Ile Ile Ala Lys Ala 
    210                 215                 220                 
Asp Pro Pro Ser Cys Asp Leu Gln Ser Ala His Gly Asn Pro Cys Met 
225                 230                 235                 240 
Lys Glu Lys Leu Val Met Lys Thr His Cys Pro Asn Asp Tyr Gln Ser 
                245                 250                 255     
Ala His Tyr Leu Asn Asn Asp Gly Lys Val Ala Ser Val Lys Cys Pro 
            260                 265                 270         
Pro Lys Tyr Glu Leu Thr Glu Asp Cys Asn Phe Cys Arg Gln Met Thr 
        275                 280                 285             
Gly Ala Ser Leu Lys Lys Gly Ser Tyr Pro Leu Gln Asp Leu Phe Cys 
    290                 295                 300                 
Gln Ser Ser Glu Asp Asp Gly Ser Lys Leu Lys Thr Lys Met Lys Gly 
305                 310                 315                 320 
Val Cys Glu Val Gly Val Gln Ala Leu Lys Lys Cys Asn Gly Gln Leu 
                325                 330                 335     
Ser Thr Ala His Glu Val Val Pro Phe Ala Val Phe Lys Asn Ser Lys 
            340                 345                 350         
Lys Val Tyr Leu Asp Lys Leu Asp Leu Lys Thr Glu Glu Asn Leu Leu 
        355                 360                 365             
Pro Asp Ser Phe Val Cys Phe Glu His Lys Gly Gln Tyr Lys Gly Thr 
    370                 375                 380                 
Met Asp Ser Gly Gln Thr Lys Arg Glu Leu Lys Ser Ser Asp Ile Ser 
385                 390                 395                 400 
Gln Cys Pro Lys Ile Gly Gly His Gly Ser Lys Lys Cys Thr Gly Asp 
                405                 410                 415     
Ala Ala Phe Cys Ser Ala Tyr Glu Cys Thr Thr Gln Tyr Ala Asn Val 
            420                 425                 430         
Tyr Cys Ser His Ala Asn Gly Ser Gly Ile Val Gln Ile Gln Val Ser 
        435                 440                 445             
Gly Val Trp Lys Lys Pro Leu Cys Val Gly Tyr Glu Arg Val Val Val 
    450                 455                 460                 
Lys Arg Glu Leu Ser Ala Lys Pro Ile Gln Arg Val Glu Pro Cys Thr 
465                 470                 475                 480 
Thr Cys Ile Thr Lys Cys Gly Pro His Gly Leu Val Val Arg Ser Thr 
                485                 490                 495     
Gly Phe Lys Ile Ser Ser Ala Val Ala Cys Ala Ser Gly Val Cys Val 
            500                 505                 510         
Thr Gly Ser Gln Ser Pro Ser Thr Glu Ile Thr Leu Lys Tyr Pro Gly 
        515                 520                 525             
Ile Ser Gln Ser Ser Gly Gly Asp Ile Gly Val Tyr Met Ala His Asp 
    530                 535                 540                 
Asp Gln Ser Val Ser Ser Lys Ile Val Ala His Cys Pro Pro Gln Asp 
545                 550                 555                 560 
Pro Cys Leu Val His Gly Cys Ile Val Cys Ala His Gly Leu Ile Asn 
                565                 570                 575     
Tyr Gln Cys His Thr Thr Leu Ser Ala Phe Ile Val Val Phe Val Phe 
            580                 585                 590         
Ser Ser Ile Ala Ile Thr Cys Leu Ala Ile Leu Tyr Arg Val Leu Lys 
        595                 600                 605             
Cys Leu Lys Ile Ala Pro Arg Lys Val Leu Asn Pro Leu Met Trp Ile 
    610                 615                 620                 
Thr Ala Phe Ile Arg Trp Val Tyr Lys Lys Met Val Ala Arg Val Ala 
625                 630                 635                 640 
Asp Asn Ile Asn Gln Val Asn Arg Glu Ile Gly Trp Met Glu Gly Gly 
                645                 650                 655     
Gln Leu Val Leu Gly Asn Pro Ala Pro Ile Pro Arg His Ala Pro Ile 
            660                 665                 670         
Pro Arg Tyr Ser Thr Tyr Leu Met Leu Leu Leu Ile Val Ser Tyr Ala 
        675                 680                 685             
Ser Ala Cys Ser Glu Leu Ile Gln Ala Ser Ser Arg Ile Thr Thr Cys 
    690                 695                 700                 
Ser Thr Glu Gly Val Asn Thr Lys Cys Arg Leu Ser Gly Thr Ala Leu 
705                 710                 715                 720 
Ile Arg Ala Gly Ser Val Gly Ala Glu Ala Cys Leu Met Leu Lys Gly 
                725                 730                 735     
Val Lys Glu Asp Gln Thr Lys Phe Leu Lys Ile Lys Thr Val Ser Ser 
            740                 745                 750         
Glu Leu Ser Cys Arg Glu Gly Gln Ser Tyr Trp Thr Gly Ser Phe Ser 
        755                 760                 765             
Pro Lys Cys Leu Ser Ser Arg Arg Cys His Leu Val Gly Glu Cys His 
    770                 775                 780                 
Val Asn Arg Cys Leu Ser Trp Arg Asp Asn Glu Thr Ser Ala Glu Phe 
785                 790                 795                 800 
Ser Phe Val Gly Glu Ser Thr Thr Met Arg Glu Asn Lys Cys Phe Glu 
                805                 810                 815     
Gln Cys Gly Gly Trp Gly Cys Gly Cys Phe Asn Val Asn Pro Ser Cys 
            820                 825                 830         
Leu Phe Val His Thr Tyr Leu Gln Ser Val Arg Lys Glu Ala Leu Arg 
        835                 840                 845             
Val Phe Asn Cys Ile Asp Trp Val His Lys Leu Ser Leu Glu Ile Thr 
    850                 855                 860                 
Asp Phe Asp Gly Ser Val Ser Thr Ile Asp Leu Gly Ala Ser Ser Ser 
865                 870                 875                 880 
Arg Phe Thr Asn Trp Gly Ser Val Ser Leu Ser Leu Asp Ala Glu Gly 
                885                 890                 895     
Ile Ser Gly Ser Asn Ser Phe Ser Phe Ile Glu Ser Pro Gly Lys Gly 
            900                 905                 910         
Tyr Ala Ile Val Asp Glu Pro Phe Ser Glu Ile Pro Arg Gln Gly Phe 
        915                 920                 925             
Leu Gly Glu Ile Arg Cys Asn Ser Glu Ser Ser Val Leu Ser Ala His 
    930                 935                 940                 
Glu Ser Cys Leu Arg Val Pro Asn Leu Ile Ser Tyr Lys Pro Met Ile 
945                 950                 955                 960 
Asp Gln Leu Glu Cys Thr Thr Asn Leu Ile Asp Pro Phe Val Val Phe 
                965                 970                 975     
Glu Arg Gly Ser Leu Pro Gln Thr Arg Asn Glu Lys Thr Phe Ala Ala 
            980                 985                 990         
Ser Lys Gly Asn Arg Gly Val Gln Ala Phe Ser Lys Gly Ser Val Gln 
        995                 1000                1005            
Ala Asp Leu Thr Leu Met Phe Asp Asn Phe Glu Val Asp Phe Val Gly 
    1010                1015                1020                
Ala Ala Val Ser Cys Asp Ala Ala Phe Leu Asn Leu Thr Gly Cys Tyr 
1025                1030                1035                1040
Ser Cys Asn Ala Gly Ala Arg Val Cys Leu Ser Ile Thr Ser Thr Gly 
                1045                1050                1055    
Thr Gly Thr Leu Ser Ala His Asn Lys Asp Gly Ser Leu His Ile Val 
            1060                1065                1070        
Leu Pro Ser Glu Asn Gly Thr Lys Asp Gln Cys Gln Ile Leu His Phe 
        1075                1080                1085            
Thr Ile Pro Glu Val Glu Glu Glu Phe Met Tyr Ser Cys Asp Gly Asp 
    1090                1095                1100                
Glu Arg Pro Leu Leu Val Lys Gly Thr Leu Ile Val Ile Asp Pro Phe 
1105                1110                1115                1120
Asp Asp Arg Arg Glu Ala Gly Gly Glu Ser Thr Val Val Asn Pro Lys 
                1125                1130                1135    
Ser Gly Ser Trp Asn Phe Phe Asp Trp Phe Ser Gly Leu Met Ser Trp 
            1140                1145                1150        
Phe Gly Gly Pro Leu Lys Thr Ile Leu Leu Ile Cys Leu Tyr Val Ala 
        1155                1160                1165            
Leu Ser Ile Gly Leu Phe Phe Leu Leu Ile Tyr Leu Gly Lys Thr Gly 
    1170                1175                1180                
Leu Ser Lys Met Trp Leu Ala Ala Thr Lys Lys Ala Ser 
1185                1190                1195        

<210> 6
<211> 265
<212> PRT
<213> Secuencia Artificial


<220> 
<223> Proteína NSs virus VFVR FMH-P8

<220> 
<221> MUTAGEN
<222> 52
<223> Ile

<220> 
<221> MUTAGEN
<222> 82
<223> Leu

<400> 6
Met Asp Tyr Phe Pro Val Ile Ser Val Asp Leu Gln Ser Gly Arg Arg 
1               5                   10                  15      
Val Val Ser Val Glu Tyr Ile Arg Gly Asp Gly Pro Pro Arg Ile Pro 
            20                  25                  30          
Tyr Ser Met Val Gly Pro Cys Cys Val Phe Leu Met His His Arg Pro 
        35                  40                  45              
Ser His Glu Ile Arg Leu Arg Phe Ser Asp Phe Tyr Asn Val Gly Glu 
    50                  55                  60                  
Phe Pro Tyr Arg Val Gly Leu Gly Asp Phe Val Ser Asn Val Ala Pro 
65                  70                  75                  80  
Pro Leu Ala Lys Pro Phe Gln Arg Leu Ile Asp Leu Ile Gly His Met 
                85                  90                  95      
Thr Leu Ser Asp Phe Thr Arg Phe Pro Asn Leu Lys Glu Ala Ile Ser 
            100                 105                 110         
Trp Pro Leu Gly Glu Pro Ser Leu Ala Phe Phe Asp Leu Ser Ser Thr 
        115                 120                 125             
Arg Val His Arg Ser Asp Asp Ile Arg Arg Asp Gln Ile Ala Thr Leu 
    130                 135                 140                 
Ala Met Arg Ser Cys Lys Ile Thr Asn Asp Leu Glu Asp Ser Phe Val 
145                 150                 155                 160 
Gly Leu His Arg Met Ile Val Thr Glu Ala Ile Leu Arg Gly Ile Asp 
                165                 170                 175     
Leu Cys Leu Leu Pro Gly Phe Asp Leu Met Tyr Glu Val Ala His Val 
            180                 185                 190         
Gln Cys Val Arg Leu Leu Gln Ala Ala Arg Glu Asp Ile Ser Asn Ala 
        195                 200                 205             
Val Val Pro Asn Ser Ala Leu Ile Ala Leu Met Glu Glu Ser Leu Met 
    210                 215                 220                 
Leu Arg Ser Ser Leu Pro Ser Met Met Gly Arg Asn Asn Trp Val Pro 
225                 230                 235                 240 
Val Val Pro Pro Ile Pro Asp Val Glu Ile Glu Ser Glu Glu Glu Ser 
                245                 250                 255     
Asp Asp Asp Gly Phe Val Glu Val Asp 
            260                 265 

<210> 7
<211> 245
<212> PRT
<213> Secuencia Artificial


<220> 
<223> Proteína N virus VFVR FMH-P8

<400> 7
Met Asp Asn Tyr Gln Glu Leu Ala Ile Gln Phe Ala Ala Gln Ala Val 
1               5                   10                  15      
Asp Arg Asn Glu Ile Glu Gln Trp Val Arg Glu Phe Ala Tyr Gln Gly 
            20                  25                  30          
Phe Asp Ala Arg Arg Val Ile Glu Leu Leu Lys Gln Tyr Gly Gly Ala 
        35                  40                  45              
Gly Trp Glu Lys Asp Ala Lys Lys Met Ile Val Leu Ala Leu Thr Arg 
    50                  55                  60                  
Gly Asn Lys Pro Arg Arg Met Met Met Lys Met Ser Lys Glu Gly Lys 
65                  70                  75                  80  
Ala Thr Val Glu Ala Leu Ile Asn Lys Tyr Lys Leu Lys Glu Gly Asn 
                85                  90                  95      
Pro Ser Arg Asp Glu Leu Thr Leu Ser Arg Val Ala Ala Ala Leu Ala 
            100                 105                 110         
Gly Trp Thr Cys Gln Ala Leu Val Val Leu Ser Glu Trp Leu Pro Val 
        115                 120                 125             
Thr Gly Thr Thr Met Asp Gly Leu Ser Pro Ala Tyr Pro Arg His Met 
    130                 135                 140                 
Met His Pro Ser Phe Ala Gly Met Val Asp Pro Ser Leu Pro Glu Asp 
145                 150                 155                 160 
Tyr Leu Arg Ala Ile Leu Asp Ala His Ser Leu Tyr Leu Leu Gln Phe 
                165                 170                 175     
Ser Arg Val Ile Asn Pro Asn Leu Arg Gly Arg Thr Lys Glu Glu Val 
            180                 185                 190         
Ala Ala Thr Phe Thr Gln Pro Met Asn Ala Ala Val Asn Ser Asn Phe 
        195                 200                 205             
Ile Ser His Glu Lys Arg Arg Glu Phe Leu Lys Ala Phe Gly Leu Val 
    210                 215                 220                 
Asp Ser Asn Gly Lys Pro Ser Ala Ala Val Met Ala Ala Ala Gln Ala 
225                 230                 235                 240 
Tyr Lys Thr Ala Ala 
                245 

<210> 8
<211> 30
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador Segmento L extremo 5’

<400> 8
acacaaaggc gcccaatcat ggattctata                                     30


<210> 9
<211> 17
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador 716F

<400> 9
cagtcacaga atctgtg                                                   17


<210> 10
<211> 17
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador Segmento L-F 1028ag

<400> 10
atggcaaaga tctgtgc                                                   17


<210> 11
<211> 20
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador L-R 2300g

<400> 11
aagtaaccat tgtaacaaca                                                20


<210> 12
<211> 23
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador RdRp central-F

<400> 12
gctatccaga agtttgagga ttg                                            23


<210> 13
<211> 23
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador Segmento L-F

<400> 13
ttctttgctt ctgataccct ctg                                            23


<210> 14
<211> 23
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador Segmento L-R

<400> 14
gttccacttc cttgcatcat ctg                                            23


<210> 15
<211> 23
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador RdRp central-R

<400> 15
ctgatttgca gaagctatat gct                                            23


<210> 16
<211> 17
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador 3817 F

<400> 16
gagtataaga aggcagt                                                   17


<210> 17
<211> 17
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador 4553 F

<400> 17
tcactatctt taatgag                                                   17


<210> 18
<211> 23
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador 5455 F

<400> 18
ccatttggat gcccagttta tat                                            23


<210> 19
<211> 17
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador 5583 R

<400> 19
ctgatgagaa tggtgct                                                   17


<210> 20
<211> 25
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador Q3’25nts

<400> 20
ttgtagcact atgctagtat cagaa                                          25


<210> 21
<211> 17
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador segmento L extremo q3'R

<400> 21
ttgtagcact atgctag                                                   17


<210> 22
<211> 27
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador (-2)RTsm1

<400> 22
gttttattaa caattctaac ctcggtt                                        27


<210> 23
<211> 19
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador MRV1ag

<400> 23
caaatgacta ccagtcagc                                                 19


<210> 24
<211> 24
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador RTsm2

<400> 24
caagtgaaca gggaaatagg atgg                                           24


<210> 25
<211> 24
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador Sm2

<400> 25
gaacatgctg atgcatatga gaca                                           24


<210> 26
<211> 24
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador Sm3

<400> 26
gacccatcct tattgtgggc agag                                           24


<210> 27
<211> 22
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador Sm4

<400> 27
atctggcaaa agacgattac gc                                             22


<210> 28
<211> 18
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador EM-RVFV-R

<400> 28
cacaaagacc ggtgcaac                                                  18


<210> 29
<211> 20
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador EM-RVFV-F

<400> 29
gaatcaacag ttgtgaatcc                                                20


<210> 30
<211> 19
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador NS0g

<400> 30
acacaaagac cccctagtg                                                 19


<210> 31
<211> 20
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador NS2g

<400> 31
tgatttgcag agtggtcgtc                                                20


<210> 32
<211> 22
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador R-S

<400> 32
cggacttgga gactttgcat ca                                             22


<210> 33
<211> 24
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador F-S

<400> 33
ttctttcaga ttggggaacc ttgt                                           24


<210> 34
<211> 18
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador NScag

<400> 34
ccttaacctc taatcaac                                                  18


<210> 35
<211> 23
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador SS1

<400> 35
agccacttag gctgctgtct tgt                                            23


<210> 36
<211> 30
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador RTss1

<400> 36
ctattacaat aatggacaac tatcaagagc                                     30


<210> 37
<211> 21
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador NP0ag

<400> 37
acacaaagct ccctagagat a                                              21


<210> 38
<211> 18
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador LsegcARN

<400> 38
agttttgata atcatgtc                                                  18


<210> 39
<211> 16
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador LsegvARN

<400> 39
cttttgatac atctga                                                    16


<210> 40
<211> 17
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador MsegcARN

<400> 40
gtttctctcc ctatttg                                                   17


<210> 41
<211> 18
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador MsegvARN

<400> 41
tcctccttat atatcttg                                                  18


<210> 42
<211> 18
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador SsegcARN

<400> 42
tattagatca ataagtct                                                  18


<210> 43
<211> 17
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Cebador SsegvARN

<400> 43
tctttcgaca ttttcat                                                   17


<210> 44
<211> 6404
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Segmento L virus VFVR 56/74

<220> 
<221> gen
<222> 19..6297
<223> /note="Marco abierto de lectura del segmento L virus VFVR 56/74"

<400> 44
acacaaaggc gcccaatcat ggattctata ttatcaaaac agctggttga caagactggt       60

tttgttagag tgccaatcaa gcattatgac tgtacaatgc taactctggc actcccaaca      120

tttgatgtct ccaagatggt agatagaatt accatagact tcaatttaga cgacatacaa      180

ggagcatctg aaataggctc aactttgcta ccctctatgt cgatagatgt ggaagatatg      240

gccaattttg ttcacgattt cacctttggc cacttagctg acaagactga cagactctta      300

atgcgtgagt ttcccatgat gaatgacggg tttgatcatc tgagccctga catgattatc      360

aaaactacat ctggcatgta taacatcgtt gagttcacca cctttagggg ggatgaaaga      420

ggtgcattcc aggctgccat gactaaactc gctaagtatg aggttccttg tgagaacaga      480

tctcagggca ggactgttgt tctttatgtt gttagcgcct accggcatgg tgtttggtct      540

aatttggagc tagaggactc tgaagcagag gagatggtat ataggtacag acttgccctt      600

agtgtgatgg atgagctaag gaccttgttc ccagaactgt catccacaga tgaggaacta      660

ggaaagactg agagagagtt gctagccatg gtctcctcca tccaaataaa ttggtcagtc      720

acagaatctg tgtttcctcc ctttagcaga gaaatgtttg acaggttcag atcttctcct      780

cccgattcag agtacatcac gaggatagtg agcagatgcc tcataaattc tcaagagaaa      840

ctcatcaata attccttctt tgctgaaggg aatgataaag ttttgagatt ttcaaaaaac      900

gctgaggagt gttccttggc aatagagaga gctttaaatc agtatagggc agaagacaac      960

cttagggacc tcaatgacca caagtctact attcagctgc ccccctggct gtcctatcac     1020

gatgccgatg gcaaagatct gtgccctctt cagggattag atgtgagagg agaccatccc     1080

atgtgcaacc tgtggagaga agtggttacc tctgcaaatc tagaggagat tgagaggatg     1140

cacgatgatg cagcggcaga acttgagttt gccctttcag gggtgaagga caggccagat     1200

gaaagaaaca gataccatag agtccatctg aatatggact cagatgatag tgtctacata     1260

gctgctttag gggttaatgg aaagaagcat aaagcagaca cattagtgca acaaatgaga     1320

gacaggagca aacagccctt ctctccagat catgatgtgg atcacatatc tgaatttctc     1380

tctgcatgct ctagtgactt gtgggcaaca gatgaggacc tatacaaccc tctctcttgt     1440

gataaagagc ttagattggc agctcagaga attcatcagc catccttatc agaaaggggc     1500

ttcaatgaga ttataacaga gcactacaga tttatgggaa gtaggatagg atcatggtgc     1560

caaatggtca gtttaatagg agctgagcta tcagcttctg taaagcaaca tgttaagcct     1620

aactattttg tgattaaacg actactaggt tctgggattt tcttgctgat caagcctact     1680

tccagcaaaa gccatatatt cgtgtctttt gcaattaagc gctcttgctg ggcctttgat     1740

ctctccactt ccagggtttt caaaccctac atagatgccg gggatctgtt agttactgac     1800

tttgtttctt acaaactaag taagcttacc aacctctgca agtgcgtttc gttaatggaa     1860

tcctccttct cattttgggc agaggcattt gggattccaa gctggaactt tgttagtgac     1920

ttgttcaggt cttcagactc tgcagcaatg gatgcctcat acatgggcaa actctcttta     1980

ttaacccttt tggaagacaa agcaacaact gaagagttac agactattgc aagatatata     2040

atcatggagg gctttgtctc gcccccagaa atcccaaaac ctcacaagat gacctctaag     2100

tttcccaagg ttctcaggtc agagctgcag gtttacttat taaactgctt atgcagaact     2160

atccagagaa tagcaggtga gccctttatt cttaagaaga aggatgggtc tatatcctgg     2220

ggtggcatgt ttaatccttt ttcagggcgt ccactgcttg atatgcaacc actcatcagc     2280

tgttgttaca atggttactt taaaaacaaa gaagaagaga ctgagccttc ctccctttct     2340

gggatgtata agaaaattat agaacttgag caccttagac cacagtcaga tgccttcttg     2400

ggttataaag atccagaact acctagaatg catgagttca gtgtttccta cttgaaggag     2460

gcttgcaatc atgctaagct ggtcttaagg agtctctatg gacagaattt catggagcaa     2520

atagacaacc aaattattcg agagctcagt gggttgactc tagaaagatt agccacactt     2580

aaggccacaa gcaactttaa tgagaattgg tatgtctata aggatgtggc agacaagaac     2640

tacacaaggg ataaattatt agtgaagatg tcaaaatatg cttctgaggg aaagagccta     2700

gctatccaga agtttgagga ttgcatgagg cagatagagt cacaaggatg tatgcacatt     2760

tgtttgttta agaaacaaca gcatggaggt ctgagagaga tctatgtgat gggtgcagag     2820

gaaagaattg ttcaatcggt ggtggagaca atagccaggt ctatagggaa gttctttgct     2880

tctgataccc tctgtaaccc ccccaataag gtgaaaattc ctgagacaca tggcattagg     2940

gctcggaagc aatgtaaggg gcctgtgtgg acttgtgcaa catcagatga tgcaaggaag     3000

tggaaccaag gccattttgt tacaaagttt gccctcatgc tatgtgagtt cacctctcct     3060

aagtggtggc cattgatcat taggggatgt tcaatgttta ccaggaaaag gatgatgatg     3120

aatttgaatt atcttaagat cctggatggt catcgagagc ttgatattag agatgacttt     3180

gtgatggatc tcttcaaagc ttatcatggt gaggcagaag ttccatgggc ttttaagggt     3240

aaaacatatc tggaaaccac aacagggatg atgcagggga tattgcatta tacttcctca     3300

ttattacaca ccattcatca agaatacatc cggtccttgt cctttaaaat attcaacctg     3360

aaggttgctc ctgagatgag caaaagcctg gtttgtgaca tgatgcaagg atcagatgat     3420

agtagcatgc taatcagctt cccagctgat gacgagaagg ttctcaccag atgcaaagtg     3480

gccgcagcca tatgcttccg aatgaagaag gagctgggag tgtaccttgc catctacccc     3540

tcagagaagt ccacagcaaa cacagatttt gtgatggagt acaattctga attttatttc     3600

cacacccagc atgttagacc gacgatcagg tggattgcag catgttgcag cctgccagaa     3660

gtggaaacac tagtagcccg ccaggaagag gcctctaatc taatgacttc agttactgag     3720

gggggtgggt cattctcctt agctgcaatg attcagcaag ctcagtgcac tctccattac     3780

atgctaatgg gcatgggagt gtctgagcta ttcttagagt ataagaaggc agtgctgaag     3840

tggaatgacc ctggtctggg tttcttcctg cttgacaatc cttatgcgtg cgggttggga     3900

ggttttagat ttaatctctt caaagccatc accagaactg atttgcagaa gctatatgct     3960

ttcttcatga agaaggttaa gggctcagct gctagggact gggcagatga ggatgttacc     4020

atcccagaaa cgtgtagcgt gagcccaggt ggcgctctaa ttcttagctc ctctctaaag     4080

tggggatcta ggaagaagtt tcagaaactg agagaccgtt tgaacatacc agagaactgg     4140

attgagctaa taaatgagaa tccagaggtg ctctatcgag ctcccagaac aggcccagaa     4200

atattgttgc gcattgcaga gaaagtccat agccctggtg ttgtgtcatc attgtcttct     4260

ggcaatgcag tctgtaaagt catggcctca gctgtatact tcttatcagc aacaattttt     4320

gaagacactg gacgccctga gttcaacttc ttagaggatt ccaagtacag cttgctacaa     4380

aagatggccg catattctgg ctttcatggt ttcaatgata tggagccaga agatatatta     4440

ttcctattcc cgaacattga ggaattagaa tcactggatt ctatagttta caacaaggga     4500

gaaatagaca tcatcccaag agttaatatc agggatgcaa cccaaaccag ggtcactatc     4560

tttaatgagc agaagaccct ccgaacatct ccagagaagt tggtgtcaga caagtggttc     4620

gggactcaga agagtaggat aggcaaaaca actttcctgg ctgaatggga gaagctaaag     4680

aaaattgtga agtggttgga agacactcca gaagcaactc tagctcacac tccactgaat     4740

aaccatattc aggttaggaa tttctttgct agaatggaaa gcaagcctag aacggttaga     4800

ataacaggag ctcctgtaaa gaagaggtca ggggttagca agatagctat ggttatccgt     4860

gacaatttct cccggatggg ccatcttaga ggtgtagaag acctcgctgg cttcactcgt     4920

agtgtgtcag ctgaaatcct caagcacttt ctgttctgca tactacaggg tccatacagt     4980

gagagctata agctacagct aatctacaga gtcctaagct cagtgtcaaa cgttgagata     5040

aaggaatcgg atggtaagac aaaaaccaat ttgattggga tccttcagag atttctagat     5100

ggtgatcacg ttgtccctat aattgaagag atgggagccg gaacagtggg tggattcatc     5160

aagagacaac agtctaaggt tgtgcaaaat aaagtggtct attatggagt tgggatctgg     5220

agaggcttca tggatggata tcaggtccat cttgagatag aaaatgacat aggacagccc     5280

ccaaggctta ggaatgtcac aactaactgt cagagcagcc catgggatct gagtgtccca     5340

ataaggcagt gggcagaaga catgggggtc acaaacaacc aggattattc ctctaaatct     5400

agcagaggag ctagatattg gatgcattca tttaggatgc aaggacccag caagccattt     5460

ggatgcccag tttatattat taagggtgac atgtcagatg ttatcagact gagaaaagag     5520

gaggtggaga tgaaagtacg gggctctact ctcaacttgt acactaagca ccattctcat     5580

caagacttac acattttatc ttacactgca tcagacaatg atctcagtcc aggcattttc     5640

aagtcaatat cagatgaggg agtggctcaa gccctgcagt tatttgagag ggagccaagc     5700

aactgctggg tgagatgtga gtctgtagct ccaaaattca tatcagccat ccttgagata     5760

tgtgagggga agagacagat aaaaggaatc aacagaacca gactctcaga gattgtgaga     5820

atttgttctg aatcttccct aagatcaaag gtcggatcta tgttctcatt tgtcgccaat     5880

gttgaggagg cccatgatgt tgattatgat gcgttaatgg atctaatgat agaagatgct     5940

aagaacaatg cattcagtca tgttgtcgat tgcatagagt tggatgttaa tggtccttac     6000

gagatggagt cttttgatac atctgatgtc aacctctttg ggccagccca ttacaaggac     6060

atcagttcat tatctatgat tgctcatccc ttaatggata agtttgttga ttatgccatt     6120

tccaagatgg ggagagcctc agttagaaaa gttctagaga caggtcggtg ctctagcaaa     6180

gactatgatt tatcaaaggt tctcttcaga actctacaga gaccagaaga gagcattagg     6240

atagatgatc tggagttata tgaggagaca gatgtggcgg atgacatgct aggctaagac     6300

caataagcaa agtcaggctt agatttaggg atactacgct agtattggaa tccatgtggg     6360

ttctgatact agcatagtgc tacaatattg ggcggtcttt gtgt                      6404


<210> 45
<211> 3885
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Segmento M virus VFVR 56/74

<220> 
<221> gen
<222> 21..3614
<223> /note="Gen que codifica para (poli)proteína M virus VFVR"

<400> 45
acacaaagac ggtgcattaa atgtatgttt tactaacaat tctgatcacg gttctggtgt       60

gtgaagcggt tattagagtg tctctaagct ccacaagaga agagacctgt tttggtgact      120

ccaccaaccc agagatgatt gaaggagctt gggattcact cagagaggag gagatgccag      180

aggagctctc ctgttctata tcaggcataa gggaggttaa gacctcaagc caggagttat      240

acagggcatt aaaagccatc attgctgctg atggcttgaa caacatcacc tgccatggta      300

aggatcctga ggacaagatt tctctcataa agggtcctcc tcacaaaaag cgggtgggga      360

tagttcggtg tgagagacga agagatgcta agcaaatagg gagagaaacc atggcaggga      420

ttgcaatgac agtccttcca gccttagcag tttttgcttt ggcacctgtt gtttttgctg      480

aagaccccca tctcaggaac agaccaggga aggggcacaa ctacattgac gggatgactc      540

aggaggatgc cacatgcaaa cctgtgacat atgctggggc atgtagcagt tttgatgtct      600

tgcttgaaaa ggggaaattt ccccttttcc agtcgtatgc tcatcataga actctactgg      660

aagcagttca cgacactatc attgcaaagg ctgatccacc tagctgtgac cttcagagtg      720

ctcatgggaa tccctgcatg aaagagaaac tcgtgatgaa gacacactgt ccaaatgact      780

accagtcagc tcattacctc aacaatgacg ggaaagtggc ttcagtcaag tgccctccta      840

agtatgagct cactgaggac tgcaactttt gtaggcagat gacaggtgct agcctgaaga      900

aagggtctta tcctctccaa gacttatttt gtcagtcaag tgaggatgat ggatcaaaat      960

taaaaacaaa aatgaaaggg gtctgcgaag tgggggttca agcactcaaa aagtgtgatg     1020

gccaactcag cactgcacat gaggttgtgc cctttgcagt gtttaagaac tcaaagaaag     1080

tttatcttga taagcttgac ctcaaaactg aggagaatct gctaccagac tcatttgtct     1140

gcttcgagca taagggacag tataaaggaa caatggactc tggtcagact aagagggagc     1200

tcaaaagctc tgatatctct cagtgcccca agattggagg acatggtagt aaaaagtgca     1260

ctggggacgc agcattttgc tctgcttatg agtgcactgc tcagtacgcc aatgcctact     1320

gttcacatgc taatggttca gggattgtgc agatacaagt atcaggggtc tggaagaagc     1380

ctttatgtgt agggtatgag agagtggttg tgaagagaga actctctgcc aagcccatcc     1440

agagagttga gccctgcaca acttgtataa ccaaatgtga gcctcatgga ttggttgtcc     1500

gatcaacagg gttcaagata tcatctgcag ttgcttgtgc tagcggagtt tgcgtcacag     1560

gatcgcagag tccttctacc gagattacac tcaagtatcc agggatatcc cagtcctctg     1620

ggggggacat aggggttcac atggcacatg atgatcagtc agttagctcc aaaatagtag     1680

ctcactgccc cccccaggac ccgtgcttag tgcatggctg catagtgtgt gctcatggcc     1740

tgataaatta ccagtgtcac actgctctca gtgcctttgt tgttgtgttt gtattcagtt     1800

ctattgcaat aacttgttta gctattcttt atagggtgct caagtgccta aagattgccc     1860

caaggaaggt tctaaatcca ctaatgtgga ttacagcctt catcagatgg gtgtataaga     1920

agatggttgc tagagtggca gacaatatta atcaagtgaa cagggaaata ggatggatgg     1980

aagggggtca gttggttcta gggaaccctg cccctattcc tcgtcatgcc ccaatcccac     2040

gttatagcac atacctaatg ctactattga ttgtctcata tgcatcagca tgttcagaac     2100

tgattcaggc aagctccaga atcaccactt gctccacaga gggtgttaac accaagtgta     2160

gactgtctgg cacagcattg atcagggcag ggtcagttgg ggcagaggct tgtttaatgt     2220

tgaagggggt caaggaagat caaaccaaat tcttgaagat aaaaactgtc tcaagtgagc     2280

tatcgtgcag ggagggccag agctattgga ctgggtcctt tagccccaaa tgtctgagct     2340

caaggagatg ccatcttgtt ggagaatgtc atgtgaatag gtgtctgtct tggagggaca     2400

atgaaacttc agcagagttt tcatttgttg gggaaagcac gaccatgcga gagaataagt     2460

gttttgagca gtgtggagga tgggggtgtg ggtgcttcaa tgtgaaccca tcttgcttat     2520

ttgtgcacac gtacctgcag tcagttagaa aagaggccct tagagttttt aactgtatcg     2580

actgggtgca taaactcagt ctagagatca cagactttga tggctctgtt tcaacaatag     2640

acttgggagc atcatctagc cgtttcacaa actggggttc agttagcctc tcactggacg     2700

cagagggtat ttcaggctca aatagctttt ctttcattga gagcccaggc aaagggtatg     2760

caattgttga tgagccattc tcagaaattc ctcggcaagg gttcttgggg gagatcaggt     2820

gtaattcaga gtcctcagtc ctgagtgctc atgaatcatg ccttagggca ccaaacctta     2880

tctcatacaa gcccatgata gatcaattgg agtgcacaac aaatctgatt gatccttttg     2940

ttgtctttga gaggggttct ctgccacaga caaggaatga aaaaaccttt gcagcttcaa     3000

aaggaaatag gggtgttcaa gctttctcta agggctctgt acaagctgat ctaactctga     3060

tgtttgacaa ttttgaggtg gactttgtgg gagcagccgt atcttgtgat gccgccttct     3120

taaacttgac aggttgctat tcttgcaatg cgggagccag ggtctgcctg tctatcacat     3180

ccacaggaac tggaactctc tctgcccaca ataaggatgg gtctctgcac atagttcttc     3240

catcagagaa tggaacaaaa gatcagtgtc agatactaca cttcactgta cctgaagtag     3300

aggaggagtt tatgtactct tgtgatggag atgagcggcc tctgttggtg aaagggaccc     3360

tgatagctat tgatccattt gatgataggc gggaagcagg gggggaatca acagttgtga     3420

atccaaaatc tggatcttgg aatttctttg actggttttc tggactcatg agttggtttg     3480

gagggcctct taaaactata ctcctcattt gcctgtatgt tgcattatca attgggctct     3540

ttttcctcct tatatatctt ggaagaacag gcctctctaa aatgtggctt gctgctacta     3600

agaaggcctc atagatcagt acgtgtagaa gcaatatgta gaaacaagtg gacataagca     3660

aacctaatta tgtaaatatt gtacagatag gtcaaattat tgggatatcc aagcttagat     3720

gcttatgcaa tattactttt gatgtaagct tagttgtaat ttggggtggt ggggtgaggc     3780

agcagcagtc tcaagtgctt gtgaatattc tagttggcgt aattgtcttt tgccagatta     3840

gctgggaatt aaactaactc tttgaagttg caccggtctt tgtgt                     3885


<210> 46
<211> 1691
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Segmento S virus VFVR 56/74

<220> 
<221> gen
<222> 35..832
<223> /note="Gen que codifica para proteína NSs virus VFVR 56/74"

<220> 
<221> gen
<222> 916..1653
<223> /note="Gen que codifica para proteína N virus VFVR 56/74
      (complementario)"

<400> 46
acacaaagac cccctagtgc ttatcaagtg tatcatggat tactttcctg tgatatctgt      60

tgatttgcag agtggtcgtc gtgttgtgtc agtggagtac attagaggtg atggtcctcc     120

caggatacct tattctatgg ttgggccctg ttgtgtcttt ctcatgcacc atcgtcctag     180

tcacgaggtt cgcttgcgat tctctgattt ctacaatgtc ggagaattcc cataccgagt     240

cggacttgga gactttgtat caaacgttgc acctccacca gcaaagcctt ttcagagact     300

tattgatcta ataggccata tgactcttag tgatttcaca aggttcccca atctgaaaga     360

agccatatcc tggcctcttg gagaaccctc cctggctttc tttgacctaa gctccaccag     420

agtgcatagg tctgatgata ttagaaggga ccagattgct actctagcaa tgaggagctg     480

caagattacc aatgatctgg aggactcctt tgttggctta cacaggatga tagtgaccga     540

ggctatcctc agagggattg acttgtgcct gttgccaggc tttgatctca tgtatgaggt     600

tgctcacgtt cagtgtgttc ggctcctgca ggcagcaaga gaggatattt ctaatgctgt     660

agttccaaac tcagctctca ttgctcttat ggaggagagc ttgatgctgc gctcatcact     720

ccctagcatg atggggagaa acaactgggt tccagttgtt cctccaatcc cagatgttga     780

gatagaatca gaggaagaga gtgatgacga tggatttgtt gaggttgatt agagattaag     840

gctgccccac cccccacccc caatcccgac cgtaacccca accaccccct tttccccaaa     900

cccctgggca gccacttagg ctgctgtctt gtacgcctga gcagctgcca tgacagctgc     960

tgacggcttc ccattggaat ccacaagccc aaaagctttc aagaattctc tcctcttctc    1020

atggcttata aagttgctat tcactgctgc attcattggc tgcgtgaacg ttgcggcaac    1080

ctcctccttt gttctacctc ggaggtttgg gttgatgacc cgggagaact gcagcagata    1140

cagagagtga gcatccaata ttgcccttag atagtcttct ggtagagaag ggtccaccat    1200

gccagcaaag ctggggtgca tcatatgcct tgggtatgca ggggataggc catccatggt    1260

ggtcccagtg acaggaagcc actcactcaa gacgaccaaa gcctggcaag tccagccagc    1320

cagggcagca gcaactcgtg atagagtcaa ctcatcccgg gaaggattcc cctcctttag    1380

cttatacttg ttgatgagag cctccacagt tgctttgcct tctttcgaca ttttcatcat    1440

catcctccgg ggcttgttgc cacgagtcag agccagaaca atcattttct tggcatcctt    1500

ctcccagcca gccccaccat actgctttaa gagttcgata accctacggg catcaaatcc    1560

ttgataagca aactctcgga cccactgttc aatctcattg cggtccactg cttgagcagc    1620

aaactggatc gcaagctctt gatagttgtc cattattgta atagtgtttg tatctctagg    1680

gagctttgtg t                                                         1691


<210> 47
<211> 2092
<212> PRT
<213> Secuencia Artificial


<220> 
<223> Proteína L virus VFVR 56/74

<400> 47
Met Asp Ser Ile Leu Ser Lys Gln Leu Val Asp Lys Thr Gly Phe Val 
1               5                   10                  15      
Arg Val Pro Ile Lys His Tyr Asp Cys Thr Met Leu Thr Leu Ala Leu 
            20                  25                  30          
Pro Thr Phe Asp Val Ser Lys Met Val Asp Arg Ile Thr Ile Asp Phe 
        35                  40                  45              
Asn Leu Asp Asp Ile Gln Gly Ala Ser Glu Ile Gly Ser Thr Leu Leu 
    50                  55                  60                  
Pro Ser Met Ser Ile Asp Val Glu Asp Met Ala Asn Phe Val His Asp 
65                  70                  75                  80  
Phe Thr Phe Gly His Leu Ala Asp Lys Thr Asp Arg Leu Leu Met Arg 
                85                  90                  95      
Glu Phe Pro Met Met Asn Asp Gly Phe Asp His Leu Ser Pro Asp Met 
            100                 105                 110         
Ile Ile Lys Thr Thr Ser Gly Met Tyr Asn Ile Val Glu Phe Thr Thr 
        115                 120                 125             
Phe Arg Gly Asp Glu Arg Gly Ala Phe Gln Ala Ala Met Thr Lys Leu 
    130                 135                 140                 
Ala Lys Tyr Glu Val Pro Cys Glu Asn Arg Ser Gln Gly Arg Thr Val 
145                 150                 155                 160 
Val Leu Tyr Val Val Ser Ala Tyr Arg His Gly Val Trp Ser Asn Leu 
                165                 170                 175     
Glu Leu Glu Asp Ser Glu Ala Glu Glu Met Val Tyr Arg Tyr Arg Leu 
            180                 185                 190         
Ala Leu Ser Val Met Asp Glu Leu Arg Thr Leu Phe Pro Glu Leu Ser 
        195                 200                 205             
Ser Thr Asp Glu Glu Leu Gly Lys Thr Glu Arg Glu Leu Leu Ala Met 
    210                 215                 220                 
Val Ser Ser Ile Gln Ile Asn Trp Ser Val Thr Glu Ser Val Phe Pro 
225                 230                 235                 240 
Pro Phe Ser Arg Glu Met Phe Asp Arg Phe Arg Ser Ser Pro Pro Asp 
                245                 250                 255     
Ser Glu Tyr Ile Thr Arg Ile Val Ser Arg Cys Leu Ile Asn Ser Gln 
            260                 265                 270         
Glu Lys Leu Ile Asn Asn Ser Phe Phe Ala Glu Gly Asn Asp Lys Val 
        275                 280                 285             
Leu Arg Phe Ser Lys Asn Ala Glu Glu Cys Ser Leu Ala Ile Glu Arg 
    290                 295                 300                 
Ala Leu Asn Gln Tyr Arg Ala Glu Asp Asn Leu Arg Asp Leu Asn Asp 
305                 310                 315                 320 
His Lys Ser Thr Ile Gln Leu Pro Pro Trp Leu Ser Tyr His Asp Ala 
                325                 330                 335     
Asp Gly Lys Asp Leu Cys Pro Leu Gln Gly Leu Asp Val Arg Gly Asp 
            340                 345                 350         
His Pro Met Cys Asn Leu Trp Arg Glu Val Val Thr Ser Ala Asn Leu 
        355                 360                 365             
Glu Glu Ile Glu Arg Met His Asp Asp Ala Ala Ala Glu Leu Glu Phe 
    370                 375                 380                 
Ala Leu Ser Gly Val Lys Asp Arg Pro Asp Glu Arg Asn Arg Tyr His 
385                 390                 395                 400 
Arg Val His Leu Asn Met Asp Ser Asp Asp Ser Val Tyr Ile Ala Ala 
                405                 410                 415     
Leu Gly Val Asn Gly Lys Lys His Lys Ala Asp Thr Leu Val Gln Gln 
            420                 425                 430         
Met Arg Asp Arg Ser Lys Gln Pro Phe Ser Pro Asp His Asp Val Asp 
        435                 440                 445             
His Ile Ser Glu Phe Leu Ser Ala Cys Ser Ser Asp Leu Trp Ala Thr 
    450                 455                 460                 
Asp Glu Asp Leu Tyr Asn Pro Leu Ser Cys Asp Lys Glu Leu Arg Leu 
465                 470                 475                 480 
Ala Ala Gln Arg Ile His Gln Pro Ser Leu Ser Glu Arg Gly Phe Asn 
                485                 490                 495     
Glu Ile Ile Thr Glu His Tyr Arg Phe Met Gly Ser Arg Ile Gly Ser 
            500                 505                 510         
Trp Cys Gln Met Val Ser Leu Ile Gly Ala Glu Leu Ser Ala Ser Val 
        515                 520                 525             
Lys Gln His Val Lys Pro Asn Tyr Phe Val Ile Lys Arg Leu Leu Gly 
    530                 535                 540                 
Ser Gly Ile Phe Leu Leu Ile Lys Pro Thr Ser Ser Lys Ser His Ile 
545                 550                 555                 560 
Phe Val Ser Phe Ala Ile Lys Arg Ser Cys Trp Ala Phe Asp Leu Ser 
                565                 570                 575     
Thr Ser Arg Val Phe Lys Pro Tyr Ile Asp Ala Gly Asp Leu Leu Val 
            580                 585                 590         
Thr Asp Phe Val Ser Tyr Lys Leu Ser Lys Leu Thr Asn Leu Cys Lys 
        595                 600                 605             
Cys Val Ser Leu Met Glu Ser Ser Phe Ser Phe Trp Ala Glu Ala Phe 
    610                 615                 620                 
Gly Ile Pro Ser Trp Asn Phe Val Ser Asp Leu Phe Arg Ser Ser Asp 
625                 630                 635                 640 
Ser Ala Ala Met Asp Ala Ser Tyr Met Gly Lys Leu Ser Leu Leu Thr 
                645                 650                 655     
Leu Leu Glu Asp Lys Ala Thr Thr Glu Glu Leu Gln Thr Ile Ala Arg 
            660                 665                 670         
Tyr Ile Ile Met Glu Gly Phe Val Ser Pro Pro Glu Ile Pro Lys Pro 
        675                 680                 685             
His Lys Met Thr Ser Lys Phe Pro Lys Val Leu Arg Ser Glu Leu Gln 
    690                 695                 700                 
Val Tyr Leu Leu Asn Cys Leu Cys Arg Thr Ile Gln Arg Ile Ala Gly 
705                 710                 715                 720 
Glu Pro Phe Ile Leu Lys Lys Lys Asp Gly Ser Ile Ser Trp Gly Gly 
                725                 730                 735     
Met Phe Asn Pro Phe Ser Gly Arg Pro Leu Leu Asp Met Gln Pro Leu 
            740                 745                 750         
Ile Ser Cys Cys Tyr Asn Gly Tyr Phe Lys Asn Lys Glu Glu Glu Thr 
        755                 760                 765             
Glu Pro Ser Ser Leu Ser Gly Met Tyr Lys Lys Ile Ile Glu Leu Glu 
    770                 775                 780                 
His Leu Arg Pro Gln Ser Asp Ala Phe Leu Gly Tyr Lys Asp Pro Glu 
785                 790                 795                 800 
Leu Pro Arg Met His Glu Phe Ser Val Ser Tyr Leu Lys Glu Ala Cys 
                805                 810                 815     
Asn His Ala Lys Leu Val Leu Arg Ser Leu Tyr Gly Gln Asn Phe Met 
            820                 825                 830         
Glu Gln Ile Asp Asn Gln Ile Ile Arg Glu Leu Ser Gly Leu Thr Leu 
        835                 840                 845             
Glu Arg Leu Ala Thr Leu Lys Ala Thr Ser Asn Phe Asn Glu Asn Trp 
    850                 855                 860                 
Tyr Val Tyr Lys Asp Val Ala Asp Lys Asn Tyr Thr Arg Asp Lys Leu 
865                 870                 875                 880 
Leu Val Lys Met Ser Lys Tyr Ala Ser Glu Gly Lys Ser Leu Ala Ile 
                885                 890                 895     
Gln Lys Phe Glu Asp Cys Met Arg Gln Ile Glu Ser Gln Gly Cys Met 
            900                 905                 910         
His Ile Cys Leu Phe Lys Lys Gln Gln His Gly Gly Leu Arg Glu Ile 
        915                 920                 925             
Tyr Val Met Gly Ala Glu Glu Arg Ile Val Gln Ser Val Val Glu Thr 
    930                 935                 940                 
Ile Ala Arg Ser Ile Gly Lys Phe Phe Ala Ser Asp Thr Leu Cys Asn 
945                 950                 955                 960 
Pro Pro Asn Lys Val Lys Ile Pro Glu Thr His Gly Ile Arg Ala Arg 
                965                 970                 975     
Lys Gln Cys Lys Gly Pro Val Trp Thr Cys Ala Thr Ser Asp Asp Ala 
            980                 985                 990         
Arg Lys Trp Asn Gln Gly His Phe Val Thr Lys Phe Ala Leu Met Leu 
        995                 1000                1005            
Cys Glu Phe Thr Ser Pro Lys Trp Trp Pro Leu Ile Ile Arg Gly Cys 
    1010                1015                1020                
Ser Met Phe Thr Arg Lys Arg Met Met Met Asn Leu Asn Tyr Leu Lys 
1025                1030                1035                1040
Ile Leu Asp Gly His Arg Glu Leu Asp Ile Arg Asp Asp Phe Val Met 
                1045                1050                1055    
Asp Leu Phe Lys Ala Tyr His Gly Glu Ala Glu Val Pro Trp Ala Phe 
            1060                1065                1070        
Lys Gly Lys Thr Tyr Leu Glu Thr Thr Thr Gly Met Met Gln Gly Ile 
        1075                1080                1085            
Leu His Tyr Thr Ser Ser Leu Leu His Thr Ile His Gln Glu Tyr Ile 
    1090                1095                1100                
Arg Ser Leu Ser Phe Lys Ile Phe Asn Leu Lys Val Ala Pro Glu Met 
1105                1110                1115                1120
Ser Lys Ser Leu Val Cys Asp Met Met Gln Gly Ser Asp Asp Ser Ser 
                1125                1130                1135    
Met Leu Ile Ser Phe Pro Ala Asp Asp Glu Lys Val Leu Thr Arg Cys 
            1140                1145                1150        
Lys Val Ala Ala Ala Ile Cys Phe Arg Met Lys Lys Glu Leu Gly Val 
        1155                1160                1165            
Tyr Leu Ala Ile Tyr Pro Ser Glu Lys Ser Thr Ala Asn Thr Asp Phe 
    1170                1175                1180                
Val Met Glu Tyr Asn Ser Glu Phe Tyr Phe His Thr Gln His Val Arg 
1185                1190                1195                1200
Pro Thr Ile Arg Trp Ile Ala Ala Cys Cys Ser Leu Pro Glu Val Glu 
                1205                1210                1215    
Thr Leu Val Ala Arg Gln Glu Glu Ala Ser Asn Leu Met Thr Ser Val 
            1220                1225                1230        
Thr Glu Gly Gly Gly Ser Phe Ser Leu Ala Ala Met Ile Gln Gln Ala 
        1235                1240                1245            
Gln Cys Thr Leu His Tyr Met Leu Met Gly Met Gly Val Ser Glu Leu 
    1250                1255                1260                
Phe Leu Glu Tyr Lys Lys Ala Val Leu Lys Trp Asn Asp Pro Gly Leu 
1265                1270                1275                1280
Gly Phe Phe Leu Leu Asp Asn Pro Tyr Ala Cys Gly Leu Gly Gly Phe 
                1285                1290                1295    
Arg Phe Asn Leu Phe Lys Ala Ile Thr Arg Thr Asp Leu Gln Lys Leu 
            1300                1305                1310        
Tyr Ala Phe Phe Met Lys Lys Val Lys Gly Ser Ala Ala Arg Asp Trp 
        1315                1320                1325            
Ala Asp Glu Asp Val Thr Ile Pro Glu Thr Cys Ser Val Ser Pro Gly 
    1330                1335                1340                
Gly Ala Leu Ile Leu Ser Ser Ser Leu Lys Trp Gly Ser Arg Lys Lys 
1345                1350                1355                1360
Phe Gln Lys Leu Arg Asp Arg Leu Asn Ile Pro Glu Asn Trp Ile Glu 
                1365                1370                1375    
Leu Ile Asn Glu Asn Pro Glu Val Leu Tyr Arg Ala Pro Arg Thr Gly 
            1380                1385                1390        
Pro Glu Ile Leu Leu Arg Ile Ala Glu Lys Val His Ser Pro Gly Val 
        1395                1400                1405            
Val Ser Ser Leu Ser Ser Gly Asn Ala Val Cys Lys Val Met Ala Ser 
    1410                1415                1420                
Ala Val Tyr Phe Leu Ser Ala Thr Ile Phe Glu Asp Thr Gly Arg Pro 
1425                1430                1435                1440
Glu Phe Asn Phe Leu Glu Asp Ser Lys Tyr Ser Leu Leu Gln Lys Met 
                1445                1450                1455    
Ala Ala Tyr Ser Gly Phe His Gly Phe Asn Asp Met Glu Pro Glu Asp 
            1460                1465                1470        
Ile Leu Phe Leu Phe Pro Asn Ile Glu Glu Leu Glu Ser Leu Asp Ser 
        1475                1480                1485            
Ile Val Tyr Asn Lys Gly Glu Ile Asp Ile Ile Pro Arg Val Asn Ile 
    1490                1495                1500                
Arg Asp Ala Thr Gln Thr Arg Val Thr Ile Phe Asn Glu Gln Lys Thr 
1505                1510                1515                1520
Leu Arg Thr Ser Pro Glu Lys Leu Val Ser Asp Lys Trp Phe Gly Thr 
                1525                1530                1535    
Gln Lys Ser Arg Ile Gly Lys Thr Thr Phe Leu Ala Glu Trp Glu Lys 
            1540                1545                1550        
Leu Lys Lys Ile Val Lys Trp Leu Glu Asp Thr Pro Glu Ala Thr Leu 
        1555                1560                1565            
Ala His Thr Pro Leu Asn Asn His Ile Gln Val Arg Asn Phe Phe Ala 
    1570                1575                1580                
Arg Met Glu Ser Lys Pro Arg Thr Val Arg Ile Thr Gly Ala Pro Val 
1585                1590                1595                1600
Lys Lys Arg Ser Gly Val Ser Lys Ile Ala Met Val Ile Arg Asp Asn 
                1605                1610                1615    
Phe Ser Arg Met Gly His Leu Arg Gly Val Glu Asp Leu Ala Gly Phe 
            1620                1625                1630        
Thr Arg Ser Val Ser Ala Glu Ile Leu Lys His Phe Leu Phe Cys Ile 
        1635                1640                1645            
Leu Gln Gly Pro Tyr Ser Glu Ser Tyr Lys Leu Gln Leu Ile Tyr Arg 
    1650                1655                1660                
Val Leu Ser Ser Val Ser Asn Val Glu Ile Lys Glu Ser Asp Gly Lys 
1665                1670                1675                1680
Thr Lys Thr Asn Leu Ile Gly Ile Leu Gln Arg Phe Leu Asp Gly Asp 
                1685                1690                1695    
His Val Val Pro Ile Ile Glu Glu Met Gly Ala Gly Thr Val Gly Gly 
            1700                1705                1710        
Phe Ile Lys Arg Gln Gln Ser Lys Val Val Gln Asn Lys Val Val Tyr 
        1715                1720                1725            
Tyr Gly Val Gly Ile Trp Arg Gly Phe Met Asp Gly Tyr Gln Val His 
    1730                1735                1740                
Leu Glu Ile Glu Asn Asp Ile Gly Gln Pro Pro Arg Leu Arg Asn Val 
1745                1750                1755                1760
Thr Thr Asn Cys Gln Ser Ser Pro Trp Asp Leu Ser Val Pro Ile Arg 
                1765                1770                1775    
Gln Trp Ala Glu Asp Met Gly Val Thr Asn Asn Gln Asp Tyr Ser Ser 
            1780                1785                1790        
Lys Ser Ser Arg Gly Ala Arg Tyr Trp Met His Ser Phe Arg Met Gln 
        1795                1800                1805            
Gly Pro Ser Lys Pro Phe Gly Cys Pro Val Tyr Ile Ile Lys Gly Asp 
    1810                1815                1820                
Met Ser Asp Val Ile Arg Leu Arg Lys Glu Glu Val Glu Met Lys Val 
1825                1830                1835                1840
Arg Gly Ser Thr Leu Asn Leu Tyr Thr Lys His His Ser His Gln Asp 
                1845                1850                1855    
Leu His Ile Leu Ser Tyr Thr Ala Ser Asp Asn Asp Leu Ser Pro Gly 
            1860                1865                1870        
Ile Phe Lys Ser Ile Ser Asp Glu Gly Val Ala Gln Ala Leu Gln Leu 
        1875                1880                1885            
Phe Glu Arg Glu Pro Ser Asn Cys Trp Val Arg Cys Glu Ser Val Ala 
    1890                1895                1900                
Pro Lys Phe Ile Ser Ala Ile Leu Glu Ile Cys Glu Gly Lys Arg Gln 
1905                1910                1915                1920
Ile Lys Gly Ile Asn Arg Thr Arg Leu Ser Glu Ile Val Arg Ile Cys 
                1925                1930                1935    
Ser Glu Ser Ser Leu Arg Ser Lys Val Gly Ser Met Phe Ser Phe Val 
            1940                1945                1950        
Ala Asn Val Glu Glu Ala His Asp Val Asp Tyr Asp Ala Leu Met Asp 
        1955                1960                1965            
Leu Met Ile Glu Asp Ala Lys Asn Asn Ala Phe Ser His Val Val Asp 
    1970                1975                1980                
Cys Ile Glu Leu Asp Val Asn Gly Pro Tyr Glu Met Glu Ser Phe Asp 
1985                1990                1995                2000
Thr Ser Asp Val Asn Leu Phe Gly Pro Ala His Tyr Lys Asp Ile Ser 
                2005                2010                2015    
Ser Leu Ser Met Ile Ala His Pro Leu Met Asp Lys Phe Val Asp Tyr 
            2020                2025                2030        
Ala Ile Ser Lys Met Gly Arg Ala Ser Val Arg Lys Val Leu Glu Thr 
        2035                2040                2045            
Gly Arg Cys Ser Ser Lys Asp Tyr Asp Leu Ser Lys Val Leu Phe Arg 
    2050                2055                2060                
Thr Leu Gln Arg Pro Glu Glu Ser Ile Arg Ile Asp Asp Leu Glu Leu 
2065                2070                2075                2080
Tyr Glu Glu Thr Asp Val Ala Asp Asp Met Leu Gly 
                2085                2090        

<210> 48
<211> 1197
<212> PRT
<213> Secuencia Artificial


<220> 
<223> (Poli)proteína M virus VFVR 56/74

<400> 48
Met Tyr Val Leu Leu Thr Ile Leu Ile Thr Val Leu Val Cys Glu Ala 
1               5                   10                  15      
Val Ile Arg Val Ser Leu Ser Ser Thr Arg Glu Glu Thr Cys Phe Gly 
            20                  25                  30          
Asp Ser Thr Asn Pro Glu Met Ile Glu Gly Ala Trp Asp Ser Leu Arg 
        35                  40                  45              
Glu Glu Glu Met Pro Glu Glu Leu Ser Cys Ser Ile Ser Gly Ile Arg 
    50                  55                  60                  
Glu Val Lys Thr Ser Ser Gln Glu Leu Tyr Arg Ala Leu Lys Ala Ile 
65                  70                  75                  80  
Ile Ala Ala Asp Gly Leu Asn Asn Ile Thr Cys His Gly Lys Asp Pro 
                85                  90                  95      
Glu Asp Lys Ile Ser Leu Ile Lys Gly Pro Pro His Lys Lys Arg Val 
            100                 105                 110         
Gly Ile Val Arg Cys Glu Arg Arg Arg Asp Ala Lys Gln Ile Gly Arg 
        115                 120                 125             
Glu Thr Met Ala Gly Ile Ala Met Thr Val Leu Pro Ala Leu Ala Val 
    130                 135                 140                 
Phe Ala Leu Ala Pro Val Val Phe Ala Glu Asp Pro His Leu Arg Asn 
145                 150                 155                 160 
Arg Pro Gly Lys Gly His Asn Tyr Ile Asp Gly Met Thr Gln Glu Asp 
                165                 170                 175     
Ala Thr Cys Lys Pro Val Thr Tyr Ala Gly Ala Cys Ser Ser Phe Asp 
            180                 185                 190         
Val Leu Leu Glu Lys Gly Lys Phe Pro Leu Phe Gln Ser Tyr Ala His 
        195                 200                 205             
His Arg Thr Leu Leu Glu Ala Val His Asp Thr Ile Ile Ala Lys Ala 
    210                 215                 220                 
Asp Pro Pro Ser Cys Asp Leu Gln Ser Ala His Gly Asn Pro Cys Met 
225                 230                 235                 240 
Lys Glu Lys Leu Val Met Lys Thr His Cys Pro Asn Asp Tyr Gln Ser 
                245                 250                 255     
Ala His Tyr Leu Asn Asn Asp Gly Lys Val Ala Ser Val Lys Cys Pro 
            260                 265                 270         
Pro Lys Tyr Glu Leu Thr Glu Asp Cys Asn Phe Cys Arg Gln Met Thr 
        275                 280                 285             
Gly Ala Ser Leu Lys Lys Gly Ser Tyr Pro Leu Gln Asp Leu Phe Cys 
    290                 295                 300                 
Gln Ser Ser Glu Asp Asp Gly Ser Lys Leu Lys Thr Lys Met Lys Gly 
305                 310                 315                 320 
Val Cys Glu Val Gly Val Gln Ala Leu Lys Lys Cys Asp Gly Gln Leu 
                325                 330                 335     
Ser Thr Ala His Glu Val Val Pro Phe Ala Val Phe Lys Asn Ser Lys 
            340                 345                 350         
Lys Val Tyr Leu Asp Lys Leu Asp Leu Lys Thr Glu Glu Asn Leu Leu 
        355                 360                 365             
Pro Asp Ser Phe Val Cys Phe Glu His Lys Gly Gln Tyr Lys Gly Thr 
    370                 375                 380                 
Met Asp Ser Gly Gln Thr Lys Arg Glu Leu Lys Ser Ser Asp Ile Ser 
385                 390                 395                 400 
Gln Cys Pro Lys Ile Gly Gly His Gly Ser Lys Lys Cys Thr Gly Asp 
                405                 410                 415     
Ala Ala Phe Cys Ser Ala Tyr Glu Cys Thr Ala Gln Tyr Ala Asn Ala 
            420                 425                 430         
Tyr Cys Ser His Ala Asn Gly Ser Gly Ile Val Gln Ile Gln Val Ser 
        435                 440                 445             
Gly Val Trp Lys Lys Pro Leu Cys Val Gly Tyr Glu Arg Val Val Val 
    450                 455                 460                 
Lys Arg Glu Leu Ser Ala Lys Pro Ile Gln Arg Val Glu Pro Cys Thr 
465                 470                 475                 480 
Thr Cys Ile Thr Lys Cys Glu Pro His Gly Leu Val Val Arg Ser Thr 
                485                 490                 495     
Gly Phe Lys Ile Ser Ser Ala Val Ala Cys Ala Ser Gly Val Cys Val 
            500                 505                 510         
Thr Gly Ser Gln Ser Pro Ser Thr Glu Ile Thr Leu Lys Tyr Pro Gly 
        515                 520                 525             
Ile Ser Gln Ser Ser Gly Gly Asp Ile Gly Val His Met Ala His Asp 
    530                 535                 540                 
Asp Gln Ser Val Ser Ser Lys Ile Val Ala His Cys Pro Pro Gln Asp 
545                 550                 555                 560 
Pro Cys Leu Val His Gly Cys Ile Val Cys Ala His Gly Leu Ile Asn 
                565                 570                 575     
Tyr Gln Cys His Thr Ala Leu Ser Ala Phe Val Val Val Phe Val Phe 
            580                 585                 590         
Ser Ser Ile Ala Ile Thr Cys Leu Ala Ile Leu Tyr Arg Val Leu Lys 
        595                 600                 605             
Cys Leu Lys Ile Ala Pro Arg Lys Val Leu Asn Pro Leu Met Trp Ile 
    610                 615                 620                 
Thr Ala Phe Ile Arg Trp Val Tyr Lys Lys Met Val Ala Arg Val Ala 
625                 630                 635                 640 
Asp Asn Ile Asn Gln Val Asn Arg Glu Ile Gly Trp Met Glu Gly Gly 
                645                 650                 655     
Gln Leu Val Leu Gly Asn Pro Ala Pro Ile Pro Arg His Ala Pro Ile 
            660                 665                 670         
Pro Arg Tyr Ser Thr Tyr Leu Met Leu Leu Leu Ile Val Ser Tyr Ala 
        675                 680                 685             
Ser Ala Cys Ser Glu Leu Ile Gln Ala Ser Ser Arg Ile Thr Thr Cys 
    690                 695                 700                 
Ser Thr Glu Gly Val Asn Thr Lys Cys Arg Leu Ser Gly Thr Ala Leu 
705                 710                 715                 720 
Ile Arg Ala Gly Ser Val Gly Ala Glu Ala Cys Leu Met Leu Lys Gly 
                725                 730                 735     
Val Lys Glu Asp Gln Thr Lys Phe Leu Lys Ile Lys Thr Val Ser Ser 
            740                 745                 750         
Glu Leu Ser Cys Arg Glu Gly Gln Ser Tyr Trp Thr Gly Ser Phe Ser 
        755                 760                 765             
Pro Lys Cys Leu Ser Ser Arg Arg Cys His Leu Val Gly Glu Cys His 
    770                 775                 780                 
Val Asn Arg Cys Leu Ser Trp Arg Asp Asn Glu Thr Ser Ala Glu Phe 
785                 790                 795                 800 
Ser Phe Val Gly Glu Ser Thr Thr Met Arg Glu Asn Lys Cys Phe Glu 
                805                 810                 815     
Gln Cys Gly Gly Trp Gly Cys Gly Cys Phe Asn Val Asn Pro Ser Cys 
            820                 825                 830         
Leu Phe Val His Thr Tyr Leu Gln Ser Val Arg Lys Glu Ala Leu Arg 
        835                 840                 845             
Val Phe Asn Cys Ile Asp Trp Val His Lys Leu Ser Leu Glu Ile Thr 
    850                 855                 860                 
Asp Phe Asp Gly Ser Val Ser Thr Ile Asp Leu Gly Ala Ser Ser Ser 
865                 870                 875                 880 
Arg Phe Thr Asn Trp Gly Ser Val Ser Leu Ser Leu Asp Ala Glu Gly 
                885                 890                 895     
Ile Ser Gly Ser Asn Ser Phe Ser Phe Ile Glu Ser Pro Gly Lys Gly 
            900                 905                 910         
Tyr Ala Ile Val Asp Glu Pro Phe Ser Glu Ile Pro Arg Gln Gly Phe 
        915                 920                 925             
Leu Gly Glu Ile Arg Cys Asn Ser Glu Ser Ser Val Leu Ser Ala His 
    930                 935                 940                 
Glu Ser Cys Leu Arg Ala Pro Asn Leu Ile Ser Tyr Lys Pro Met Ile 
945                 950                 955                 960 
Asp Gln Leu Glu Cys Thr Thr Asn Leu Ile Asp Pro Phe Val Val Phe 
                965                 970                 975     
Glu Arg Gly Ser Leu Pro Gln Thr Arg Asn Glu Lys Thr Phe Ala Ala 
            980                 985                 990         
Ser Lys Gly Asn Arg Gly Val Gln Ala Phe Ser Lys Gly Ser Val Gln 
        995                 1000                1005            
Ala Asp Leu Thr Leu Met Phe Asp Asn Phe Glu Val Asp Phe Val Gly 
    1010                1015                1020                
Ala Ala Val Ser Cys Asp Ala Ala Phe Leu Asn Leu Thr Gly Cys Tyr 
1025                1030                1035                1040
Ser Cys Asn Ala Gly Ala Arg Val Cys Leu Ser Ile Thr Ser Thr Gly 
                1045                1050                1055    
Thr Gly Thr Leu Ser Ala His Asn Lys Asp Gly Ser Leu His Ile Val 
            1060                1065                1070        
Leu Pro Ser Glu Asn Gly Thr Lys Asp Gln Cys Gln Ile Leu His Phe 
        1075                1080                1085            
Thr Val Pro Glu Val Glu Glu Glu Phe Met Tyr Ser Cys Asp Gly Asp 
    1090                1095                1100                
Glu Arg Pro Leu Leu Val Lys Gly Thr Leu Ile Ala Ile Asp Pro Phe 
1105                1110                1115                1120
Asp Asp Arg Arg Glu Ala Gly Gly Glu Ser Thr Val Val Asn Pro Lys 
                1125                1130                1135    
Ser Gly Ser Trp Asn Phe Phe Asp Trp Phe Ser Gly Leu Met Ser Trp 
            1140                1145                1150        
Phe Gly Gly Pro Leu Lys Thr Ile Leu Leu Ile Cys Leu Tyr Val Ala 
        1155                1160                1165            
Leu Ser Ile Gly Leu Phe Phe Leu Leu Ile Tyr Leu Gly Arg Thr Gly 
    1170                1175                1180                
Leu Ser Lys Met Trp Leu Ala Ala Thr Lys Lys Ala Ser 
1185                1190                1195        

<210> 49
<211> 265
<212> PRT
<213> Secuencia Artificial


<220> 
<223> Proteína NSs virus VFVR 56/74

<400> 49
Met Asp Tyr Phe Pro Val Ile Ser Val Asp Leu Gln Ser Gly Arg Arg 
1               5                   10                  15      
Val Val Ser Val Glu Tyr Ile Arg Gly Asp Gly Pro Pro Arg Ile Pro 
            20                  25                  30          
Tyr Ser Met Val Gly Pro Cys Cys Val Phe Leu Met His His Arg Pro 
        35                  40                  45              
Ser His Glu Val Arg Leu Arg Phe Ser Asp Phe Tyr Asn Val Gly Glu 
    50                  55                  60                  
Phe Pro Tyr Arg Val Gly Leu Gly Asp Phe Val Ser Asn Val Ala Pro 
65                  70                  75                  80  
Pro Pro Ala Lys Pro Phe Gln Arg Leu Ile Asp Leu Ile Gly His Met 
                85                  90                  95      
Thr Leu Ser Asp Phe Thr Arg Phe Pro Asn Leu Lys Glu Ala Ile Ser 
            100                 105                 110         
Trp Pro Leu Gly Glu Pro Ser Leu Ala Phe Phe Asp Leu Ser Ser Thr 
        115                 120                 125             
Arg Val His Arg Ser Asp Asp Ile Arg Arg Asp Gln Ile Ala Thr Leu 
    130                 135                 140                 
Ala Met Arg Ser Cys Lys Ile Thr Asn Asp Leu Glu Asp Ser Phe Val 
145                 150                 155                 160 
Gly Leu His Arg Met Ile Val Thr Glu Ala Ile Leu Arg Gly Ile Asp 
                165                 170                 175     
Leu Cys Leu Leu Pro Gly Phe Asp Leu Met Tyr Glu Val Ala His Val 
            180                 185                 190         
Gln Cys Val Arg Leu Leu Gln Ala Ala Arg Glu Asp Ile Ser Asn Ala 
        195                 200                 205             
Val Val Pro Asn Ser Ala Leu Ile Ala Leu Met Glu Glu Ser Leu Met 
    210                 215                 220                 
Leu Arg Ser Ser Leu Pro Ser Met Met Gly Arg Asn Asn Trp Val Pro 
225                 230                 235                 240 
Val Val Pro Pro Ile Pro Asp Val Glu Ile Glu Ser Glu Glu Glu Ser 
                245                 250                 255     
Asp Asp Asp Gly Phe Val Glu Val Asp 
            260                 265 

<210> 50
<211> 245
<212> PRT
<213> Secuencia Artificial


<220> 
<223> Proteína N virus VFVR 56/74

<400> 50
Met Asp Asn Tyr Gln Glu Leu Ala Ile Gln Phe Ala Ala Gln Ala Val 
1               5                   10                  15      
Asp Arg Asn Glu Ile Glu Gln Trp Val Arg Glu Phe Ala Tyr Gln Gly 
            20                  25                  30          
Phe Asp Ala Arg Arg Val Ile Glu Leu Leu Lys Gln Tyr Gly Gly Ala 
        35                  40                  45              
Gly Trp Glu Lys Asp Ala Lys Lys Met Ile Val Leu Ala Leu Thr Arg 
    50                  55                  60                  
Gly Asn Lys Pro Arg Arg Met Met Met Lys Met Ser Lys Glu Gly Lys 
65                  70                  75                  80  
Ala Thr Val Glu Ala Leu Ile Asn Lys Tyr Lys Leu Lys Glu Gly Asn 
                85                  90                  95      
Pro Ser Arg Asp Glu Leu Thr Leu Ser Arg Val Ala Ala Ala Leu Ala 
            100                 105                 110         
Gly Trp Thr Cys Gln Ala Leu Val Val Leu Ser Glu Trp Leu Pro Val 
        115                 120                 125             
Thr Gly Thr Thr Met Asp Gly Leu Ser Pro Ala Tyr Pro Arg His Met 
    130                 135                 140                 
Met His Pro Ser Phe Ala Gly Met Val Asp Pro Ser Leu Pro Glu Asp 
145                 150                 155                 160 
Tyr Leu Arg Ala Ile Leu Asp Ala His Ser Leu Tyr Leu Leu Gln Phe 
                165                 170                 175     
Ser Arg Val Ile Asn Pro Asn Leu Arg Gly Arg Thr Lys Glu Glu Val 
            180                 185                 190         
Ala Ala Thr Phe Thr Gln Pro Met Asn Ala Ala Val Asn Ser Asn Phe 
        195                 200                 205             
Ile Ser His Glu Lys Arg Arg Glu Phe Leu Lys Ala Phe Gly Leu Val 
    210                 215                 220                 
Asp Ser Asn Gly Lys Pro Ser Ala Ala Val Met Ala Ala Ala Gln Ala 
225                 230                 235                 240 
Tyr Lys Thr Ala Ala 
                245 

<210> 51
<211> 6404
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Segmento L virus VFVR ZH548

<220> 
<221> gen
<222> 19..6297
<223> /note="Marco abierto de lectura del segmento L virus VFVR ZH548"

<400> 51
acacaaaggc gcccaatcat ggattctata ttatcaaaac agctggttga caagactggt       60

tttgttagag tgccaatcaa gcattttgac tgtacaatgc taactctggc acttccaaca      120

tttgatgttt ccaagatggt agatagaatt accatagact tcaatctgga tgatatacaa      180

ggagcatctg aaataggctc aactttgcta ccctccatgt cgatagatgt ggaagatatg      240

gccaattttg ttcacgattt cacctttggc cacttagctg acaagactga cagactgtta      300

atgcgtgagt ttcccatgat gaatgacggg tttgatcatt tgagccctga catgatcatt      360

aaaactacat ctggcatgta caacatcgtt gagttcacca cctttagggg agatgaaaga      420

ggtgcattcc aggctgccat gactaaactc gctaagtatg aggttccttg tgagaacaga      480

tctcagggca ggactgttgt tctttatgtt gttagtgctt atcggcatgg tgtatggtct      540

aatctggagc tagaggactc tgaagcagag gagatggttt ataggtacag acttgctctt      600

agtgtgatgg atgagctaag gaccttgttc ccagaactgt catccacaga tgaggaacta      660

gggaagactg agagagagtt gctagccatg gtctcctcca tccaaataaa ttggtcagtc      720

acagaatctg tgtttccacc cttcagcaga gaaatgtttg acaggtttag atcctcccct      780

cccgattcag agtatatcac gaggatagtg agcagatgcc taataaattc tcaagagaaa      840

ctcatcaata gttccttctt tgctgaaggg aatgataagg ctctgagatt ttcaaaaaac      900

gctgaagagt gttccttggc agtagagaga gccttaaatc agtatagagc agaagacaac      960

cttagggacc tcaatgacca caagtcaact attcagctgc ctccctggct gtcctatcat     1020

gatgtcgatg gcaaagatct gtgccctctt cagggactag atgtgagagg ggaccatccc     1080

atgtgcaact tgtggaggga agtggtcacc tctgcaaacc tagaggagat tgagaggatg     1140

cacgatgatg cagcagcaga acttgagttt gccctttcgg gagtaaagga caggccagat     1200

gagagaaaca gataccatag agtccaccta aatatgggct cagatgatag tgtctacata     1260

gctgctttag gagttaatgg aaagaagcat aaagcagaca ctttagtgca acaaatgaga     1320

gacaggagta aacagccttt ctccccagac cacgatgtgg atcacatatc tgaatttctc     1380

tctgcatgct ctagtgactt gtgggcaaca gatgaggacc tgtacagccc tctctcttgt     1440

gataaagagc ttagattggc agcccagagg attcatcagc catccttgtc agaaaggggt     1500

ttcaatgaga tcataacaga gcactacaaa ttcatgggaa gtaggatagg ttcatggtgc     1560

caaatggtca gcttgatagg agctgagcta tcagcttctg ttaaacaaca tgtcaagcct     1620

aactactttg tgattaaacg actactaggt tctgggattt tcttgctaat caagcccact     1680

tccagcaaaa gccatatatt tgtgtctttt gcaattaagc gctcttgctg ggcctttgat     1740

ctctccactt ccagggtttt caagccctac atagatgctg gggatctgtt agttactgac     1800

tttgtttctt ataagctaag caagcttacc aacctctgca agtgcgtttc attaatggag     1860

tcctccttct cattctgggc agaagcattt ggaattccaa gctggaactt tgttggtgac     1920

ttgttcaggt cttcagactc tgcagcaatg gatgcctcat acatgggcaa actttcttta     1980

ttaacccttt tggaagacaa agcagcaact gaagagttac agactattgc aagatatata     2040

atcatggagg gctttgtctc gcccccagaa atcccaaaac ctcacaagat gacctctaag     2100

tttcctaagg ttctcaggtc agagctgcag gtttacttat taaactgctt atgcagaact     2160

atccagagaa tagcaggtga gcccttcatt cttaagaaga aggatgggtc tatatcctgg     2220

ggtggcatgt tcaatccttt ttcagggcgt ccactgcttg atatgcaacc actcatcagc     2280

tgttgttaca atggttactt taaaaataaa gaagaagaga ctgagccttc gtccctttct     2340

gggatgtata agaaaatcat agaacttgag caccttagac cacagtcaga tgccttcttg     2400

ggttacaaag atccagaact tcccagaatg catgagttca gtgtttccta cttgaaggag     2460

gcttgcaatc atgctaagct agtcttgagg agcctctatg gacagaattt catggagcag     2520

atagacaacc agattattcg agagctcagt gggttgactc tagaaaggtt ggccacactt     2580

aaggccacaa gcaactttaa tgagaattgg tatgtctata aggatgtagc agacaaaaac     2640

tacacaaggg ataaattatt agtgaagatg tcaaaatatg cctctgaggg aaagagccta     2700

gctatccaga agtttgagga ttgtatgagg cagatagagt cacaaggatg catgcatatt     2760

tgtttgttta agaaacaaca gcatggaggt ctgagagaga tctatgtgat gggtgcagag     2820

gaaagaattg ttcaatcggt ggtggagaca atagccaggt ccatagggaa gttctttgct     2880

tctgataccc tctgtaaccc ccccaataaa gtgaaaattc ctgagacaca tggcatcagg     2940

gcccggaagc aatgtaaggg gcctgtgtgg acttgtgcaa catcagatga tgcaaggaag     3000

tggaaccaag gccattttgt tacaaagttt gccctcatgc tgtgtgagtt cacctctcct     3060

aaatggtggc cgctgatcat taggggatgc tcaatgttta ccaggaaaag gatgatgatg     3120

aatttgaatt atcttaagat cctggatggt catcgggagc ttgatattag agatgacttt     3180

gtgatggatc tcttcaaagc ttatcatggc gaggcagaag ttccatgggc ctttaaaggc     3240

aaaacatatt tggaaaccac aacagggatg atgcagggaa tactgcatta tacttcctca     3300

ctattacaca ccattcacca agaatacatc cggtccttgt cctttaagat attcaacctg     3360

aaggttgctc ctgagatgag caagagcctg gtttgtgaca tgatgcaagg atcagatgat     3420

agtagtatgc taatcagctt cccagctgat gatgagaagg ttcttaccag atgcaaagtg     3480

gccgcagcta tatgcttccg catgaagaag gagctgggag tgtaccttgc catttacccc     3540

tcagagaagt ccacagcaaa cacagatttt gtgatggagt acaattctga attttatttc     3600

cacacccagc atgttagacc aacgatcagg tggattgcag cttgttgcag cctgccagaa     3660

gtggaaacac tagtagcccg ccaggaagag gcctctaacc taatgacttc agttactgag     3720

ggaggtgggt cattctcctt agctgcaatg attcagcaag ctcagtgtac tctccattac     3780

atgctgatgg gcatgggagt gtctgagcta ttcttagagt ataagaaggc agtgctgaag     3840

tggaatgacc ctggcctggg tttcttcctg cttgacaatc cttatgcgtg cggattggga     3900

ggtttcagat ttaatctctt caaagctatc accagaactg atttgcagaa gctatatgct     3960

ttcttcatga agaaggtcaa gggctcagct gctagggact gggcagatga agatgtcacc     4020

atcccagaaa cgtgtagcgt gagcccaggt ggcgctctaa ttcttagctc ctctctaaag     4080

tggggatcta ggaagaagtt tcagaaattg agagaccgtt tgaacatacc agagaactgg     4140

attgaactaa taaatgagaa tccagaggtg ctctatcggg ctcccagaac aggcccagaa     4200

atattgttgc gcattgcaga gaaagtccat agcccaggtg ttgtgtcatc attgtcttct     4260

ggcaatgcag tttgtaaagt catggcctca gctgtatact tcttatcagc aacaattttt     4320

gaggacactg gacgtcctga gttcaacttc ttggaggatt ctaagtacag cttgctacaa     4380

aagatggctg catattctgg ctttcatggt ttcaatgata tggagccaga agatatatta     4440

ttcttattcc cgaatattga ggaattagaa tcactggatt ctatagttta caacaaggga     4500

gaaatagaca tcatcccaag agtcaacatc agggatgcaa cccaaaccag ggtcactatc     4560

tttaatgagc agaagaccct ccggacatct ccagagaagt tggtgtcaga caagtggttt     4620

gggactcaga agagtaggat aggcaaaaca accttcctgg ctgaatggga aaagctaaag     4680

aaaattgtaa agtggttgga agacactcca gaagcaactc tagctcacac cccactgaat     4740

aaccatattc aagttaggaa tttctttgct agaatggaaa gcaagcctag aacagtcaga     4800

ataacaggag ctccagtaaa gaagaggtca ggggttagta agatagctat ggttatccgt     4860

gacaatttct cccggatggg ccatcttcga ggtgtagaag accttgctgg cttcactcgt     4920

agtgtgtcag ctgaaattct caagcacttt ctattctgta tactacaagg tccatacagt     4980

gagagctata agctacagct aatctacaga gtcctaagct cagtgtcaaa cgttgagata     5040

aaggaatcag atggtaagac aaaaaccaac ttgattggaa tccttcagag atttctagat     5100

ggtgatcacg ttgtccccat aattgaagag atgggagccg gaacagtggg tggattcatc     5160

aagagacaac aatctaaagt tgtgcagaac aaagtggtct attatggagt tgggatttgg     5220

agaggcttca tggatggata tcaggtccat ctagagatag aaaatgacat aggacagccc     5280

ccaaggctta ggaatgtcac aactaactgt cagagcagcc catgggacct gagtattcca     5340

ataaggcaat gggcagaaga catgggggtc acaaacaacc aggattattc ctctaaatct     5400

agcagggggg ccagatattg gatgcattca ttcaggatgc aaggacctag caagccattt     5460

ggatgcccag tttatattat taagggtgat atgtcagatg tcatcagact gagaaaggag     5520

gaggtggaga tgaaagtacg gggctctact ctcaacttgt acaccaagca ccattctcat     5580

caggacctac acattctatc ttacactgca tcagacaatg atctcagtcc aggcattttc     5640

aagtcaatat cagatgaggg ggtggctcaa gccctgcaat tatttgagag ggagccaagc     5700

aactgctggg tgagatgtga gtctgtagcc ccaaaattta tatcagccat ccttgagata     5760

tgtgagggga agagacagat aaagggaatt aacagaacca gactctcaga gattgtgaga     5820

atttgttctg aatcttccct aagatcaaaa gtcggatcta tgttctcatt tgtcgccaat     5880

gtcgaggagg cccatgatgt tgattatgat gcgttaatgg atctaatgat agaggatgcc     5940

aagaacaatg cattcagtca tgttgttgac tgcatagagt tggatgttag tggcccttac     6000

gagatggagt cttttgatac atctgatgtc aatctctttg ggccagccca ttacaaggac     6060

atcagttcat tatctatgat tgctcatccc ttaatggata agtttgttga ttatgctatt     6120

tctaagatgg ggagagcctc agttaggaaa gttctagaaa caggtcggtg ctccagcaaa     6180

gactatgatt tatcaaaggt tctcttcaga actctacaga gaccagaaga aagcattagg     6240

atagatgatc tggaattata tgaggagaca gatgtggcgg atgacatgct aggctaagac     6300

cagtaagcaa agtcaggctt agatttaggg atactatgct agtattggaa tccatgtggg     6360

ttctgatact agcatagtgc tacaatattg ggcggtcttt gtgt                      6404


<210> 52
<211> 3885
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Segmento M virus VFVR ZH548

<220> 
<221> gen
<222> 21..3614
<223> /note="Gen que codifica para (poli)proteína M virus ZH548"

<400> 52
acacaaagac ggtgcattaa atgtatgttt tattaacaat tctaatctcg gttctggtgt       60

gtgaagcggt tattagagtg tctctaagct ccacaagaga agagacctgc tttggtgact      120

ccactaaccc agagatgatt gaaggagctt gggattcact cagagaggag gagatgccgg      180

aggagctctc ctgttctata tcaggcataa gagaggttaa gacctcaagc caggagttat      240

acagggcatt aaaagccatc attgctgctg atggcttgaa caacatcacc tgccatggta      300

aggatcctga ggacaagatt tccctcataa agggtcctcc tcacaaaaag cgggtgggga      360

tagttcggtg tgagagacga agagatgcta agcaaatagg gagagaaacc atggcaggga      420

ttgcaatgac agtccttcca gccttagcag tttttgcttt ggcacctgtt gtttttgctg      480

aagaccccca tctcagaaac agaccaggga aggggcacaa ctacattgac gggatgactc      540

aggaggatgc cacatgcaaa cctgtgacat atgctggggc atgtagcagt tttgatgtct      600

tgcttgaaaa gggaaaattt ccccttttcc agtcgtatgc tcatcataga actctactag      660

aggcagttca cgacaccatc attgcaaagg ctgatccacc tagctgtgac cttctgagtg      720

ctcatgggaa cccctgcatg aaagagaaac tcgtgatgaa gacacactgt ccaaatgact      780

accagtcagc tcattacctc aacaatgacg ggaaaatggc ttcagtcaag tgccctccta      840

agtatgagct cactgaggac tgcaactttt gtaggcagat gacaggtgct agcctgaaga      900

aggggtctta tcctctccaa gacttgtttt gtcagtcaag tgaggatgat ggatcaaaat      960

taaaaacaaa aatgaaaggg gtctgcgaag tgggggttca agcactcaaa aagtgtgatg     1020

gccaactcag cactgcacat gaggttgtgc cctttgcagt gtttaagaac tcaaagaagg     1080

tttatcttga taagcttgac cttaagactg aggagaatct gctaccagac tcatttgtct     1140

gtttcgagca taagggacag tacaaaggaa caatggactc tggtcagact aagagggagc     1200

tcaaaagctt tgatatctct cagtgcccca agattggagg acatggtagt aagaagtgca     1260

ctggggacgc agcattttgc tctgcttatg agtgcactgc tcagtacgcc aatgcctatt     1320

gttcacatgc taatgggtca gggattgtgc agatacaagt atcaggggtc tggaagaagc     1380

ctttatgtgt agggtatgag agagtggttg tgaagagaga actctctgcc aagcccatcc     1440

agagagttga gccttgcaca acttgtataa ccaaatgtga gcctcatgga ttggttgtcc     1500

gatcaacagg gttcaagata tcatcagcag ttgcttgtgc tagcggagtt tgcgtcacag     1560

gatcgcagag tccttccacc gagattacac tcaagtatcc agggatatcc cagtcttctg     1620

ggggggacat aggggttcac atggcacacg atgatcagtc agttagctcc aaaatagtag     1680

ctcactgccc tccccaggac ccgtgcttag tgcatgactg catagtgtgt gctcatggcc     1740

tgataaatta ccagtgtcac actgctctca gtgcctttgt tgttgtgttt gtattcagtt     1800

ctattgcaat aatttgttta gctattcttt atagggtgct taagtgcctg aagattgccc     1860

caaggaaagt tctgaatcca ctaatgtgga tcacagcctt catcagatgg atatataaga     1920

agatggttgc cagagtggca gacaacatta atcaagtgaa cagggaaata ggatggatgg     1980

aaggaggtca gttggttcta gggaaccctg cccctattcc tcgtcatgcc ccaatcccac     2040

gttatagcac atacctgatg ttattattga ttgtctcata tgcatcagca tgttcagaac     2100

tgattcaggc aagctccaga atcaccactt gctctacaga gggtgttaac accaagtgta     2160

gactgtctgg cacagcattg atcagagcag ggtcagttgg ggcagaggct tgtttgatgt     2220

tgaagggggt caaggaagat caaaccaagt tcttaaagat aaaaactgtc tcaagtgagc     2280

tatcatgcag ggagggccag agttattgga ctgggtcctt tagccctaaa tgtttgagct     2340

caaggagatg ccaccttgtc ggggaatgcc atgtgaatag gtgtctgtct tggagggaca     2400

atgaaacttc agcagagttt tcatttgttg gggaaagcac gaccatgcga gagaataagt     2460

gttttgagca atgtggagga tgggggtgtg ggtgtttcaa tgtgaaccca tcttgcttat     2520

ttgtgcacac gtatctgcag tcagttagaa aagaggccct tagagttttt aactgtatcg     2580

actgggtgca taaactcact ctagagatca cagactttga tggctctgtt tcaacaatag     2640

acttgggagc atcatctagc cgtttcacaa actggggttc agttagcctc tcactggacg     2700

cagagggcat ttcaggctca aatagctttt ctttcattga gagcccaggc aaagggtatg     2760

caattgttga tgagccattc tcagaaattc ctcggcaagg gttcttgggg gagatcaggt     2820

gcaattcaga gtcctcagtc ctgagtgctc atgaatcatg ccttagggca ccaaacctta     2880

tctcatacaa gcccatgata gatcaattgg agtgcacaac aaatctgatt gatccctttg     2940

ttgtctttga gaggggttct ctgccacaga caaggaatga caaaaccttt gcagcttcaa     3000

aaggaaatag aggtgttcaa gctttctcta agggctctgt acaagctgat ctaactctga     3060

tgtttgacaa ttttgaggtg gactttgtgg gagcagccgt atcttgtgat gccgccttct     3120

taaatttgac aggttgctat tcttgcaatg caggggccag ggtctgcctg tctatcacat     3180

ccacaggaac tggatctctc tctgcccaca ataaggatgg gtctctgcat atagtccttc     3240

catcagagaa tggaacaaaa gaccagtgtc agatactaca cttcactgtg cctgaagtag     3300

aggaggagtt tatgtactct tgtgatggag atgagcggcc tctgttggtg aaggggaccc     3360

tgatagccat tgatccattt gatgataggc gggaagcagg gggggaatca acagttgtga     3420

atccaaaatc tggatcttgg aatttctttg actggttttc tggactcatg agttggtttg     3480

gagggcctct taaaactata ctcctcattt gcctgtatgt tgcattatca attgggctct     3540

ttttcctcct tatatatctt ggaagaacag gcctctctaa aatgtggctt gctgccacta     3600

agaaggcctc atagatcagt acgtgtaaaa gcaatatgtt gaaataagta gacataagca     3660

aacctaatta tgtaagtatt gtacagatag gtcaaattat tggaatatcc aagcttagaa     3720

acttatgcaa taatacttta gatgtaagct tagttgtaat ttggggtggt ggggtgaggc     3780

agcagcagtc tcaagtgctt gtgaatattc tagttggcgt aatcgtcttt tgccagatta     3840

gctgggaatt aaactaactc tttgaagttg caccggtctt tgtgt                     3885


<210> 53
<211> 1690
<212> ADN
<213> Secuencia Artificial


<220> 
<223> Segmento S virus VFVR ZH548

<220> 
<221> gen
<222> 35..832
<223> /note="Gen que codifica para proteína NSs virus VFVR ZH548"

<220> 
<221> gen
<222> 915..1652
<223> /note="Gen que codifica para proteína N virus VFVR ZH548"

<400> 53
acacaaagac cccctagtgc ttatcaagta tatcatggat tactttcctg tgatatctgt      60

tgatttgcag agtggtcgtc gtgttgtgtc agtggagtac tttagaggag atggtcctcc     120

caggatacct tattctatgg ttgggccctg ttgtgtcttt ctcatgcacc atcgtcctag     180

tcacgaggtt cgcttgcgat tctctgattt ctacaatgtc ggagaattcc cataccgagt     240

cggacttgga gactttgcat caaacgttgc acctccacca gcgaagcctt ttcagagact     300

tattgatcta ataggccata tgactcttag tgatttcaca aggttcccca atctgaaaga     360

agccatatcc tggcctcttg gagaaccctc actggctttc tttgacctaa gctctactag     420

agtgcatagg aatgatgaca ttagaaggga tcagattgcc actctagcaa tgaggagttg     480

caagatcacc aatgatctag aggactcctt tgttggctta cacaggatga tagcgactga     540

ggccatcctc agagggattg acctgtgcct gttgccaggc tttgatctca tgtatgaggt     600

tgctcacgta cagtgcgttc ggcttctgca agcagcaaaa gaggacattt ctaatgctgt     660

agttccaaac tcagccctca ttgttcttat ggaggagagc ctgatgctgc gctcatcact     720

tcccagcatg atggggagaa acaactggat tccagttatt cctccaatcc cagatgttga     780

gatggaatca gaggaggaga gtgatgatga tggatttgtt gaggttgatt agaggttaag     840

gctgccccac cccccacccc ccaatcccga ccgtaacccc aactcccctt ccccccaacc     900

ccctgggcag ccacttaggc tgctgtcttg taagcctgag cggctgccat gacagcagct     960

gacggcttcc cattggaatc cacaagtcca aaggctttca agaattctct cctcttctca    1020

tggcttataa agttgctatt cactgctgca ttcattggct gcgtgaacgt tgcagcaacc    1080

tcctcttttg ttctacctcg gaggtttggg ttgatgaccc gggagaactg cagcagatac    1140

agagagtgag catctaatat tgcccttaga tagtctcctg gtagagaagg atccaccatg    1200

ccagcaaagc tggggtgcat catatgcctc gggtatgcag gggataggcc gtccatggta    1260

gtcccagtga caggaagcca ctcactcaag acgaccaaag cctggcatgt ccagccagcc    1320

aaggcggcag caactcgtga tagagtcaac tcatcccggg aaggattccc ttcctttagc    1380

ttatacttgt tgatgagagc ctccacagtt gctttgcctt ctttcgacat tttcatcatc    1440

atcctcctgg gcttgttgcc acgagttaga gccagaacaa tcattttctt ggcatccttc    1500

tcccagtcag ccccaccata ctgctttaag agttcgataa ctctacgggc atcaaaccct    1560

tgataagcaa actctcggac ccactgttca atctcattgc ggtccactgc ttgagcagca    1620

aactggatcg caagctcttg atagttgtcc attattgtaa tagtgtttgt atctctaggg    1680

agctttgtgt                                                           1690


<210> 54
<211> 2092
<212> PRT
<213> Secuencia Artificial


<220> 
<223> Proteína L virus VFVR ZH548

<400> 54
Met Asp Ser Ile Leu Ser Lys Gln Leu Val Asp Lys Thr Gly Phe Val 
1               5                   10                  15      
Arg Val Pro Ile Lys His Phe Asp Cys Thr Met Leu Thr Leu Ala Leu 
            20                  25                  30          
Pro Thr Phe Asp Val Ser Lys Met Val Asp Arg Ile Thr Ile Asp Phe 
        35                  40                  45              
Asn Leu Asp Asp Ile Gln Gly Ala Ser Glu Ile Gly Ser Thr Leu Leu 
    50                  55                  60                  
Pro Ser Met Ser Ile Asp Val Glu Asp Met Ala Asn Phe Val His Asp 
65                  70                  75                  80  
Phe Thr Phe Gly His Leu Ala Asp Lys Thr Asp Arg Leu Leu Met Arg 
                85                  90                  95      
Glu Phe Pro Met Met Asn Asp Gly Phe Asp His Leu Ser Pro Asp Met 
            100                 105                 110         
Ile Ile Lys Thr Thr Ser Gly Met Tyr Asn Ile Val Glu Phe Thr Thr 
        115                 120                 125             
Phe Arg Gly Asp Glu Arg Gly Ala Phe Gln Ala Ala Met Thr Lys Leu 
    130                 135                 140                 
Ala Lys Tyr Glu Val Pro Cys Glu Asn Arg Ser Gln Gly Arg Thr Val 
145                 150                 155                 160 
Val Leu Tyr Val Val Ser Ala Tyr Arg His Gly Val Trp Ser Asn Leu 
                165                 170                 175     
Glu Leu Glu Asp Ser Glu Ala Glu Glu Met Val Tyr Arg Tyr Arg Leu 
            180                 185                 190         
Ala Leu Ser Val Met Asp Glu Leu Arg Thr Leu Phe Pro Glu Leu Ser 
        195                 200                 205             
Ser Thr Asp Glu Glu Leu Gly Lys Thr Glu Arg Glu Leu Leu Ala Met 
    210                 215                 220                 
Val Ser Ser Ile Gln Ile Asn Trp Ser Val Thr Glu Ser Val Phe Pro 
225                 230                 235                 240 
Pro Phe Ser Arg Glu Met Phe Asp Arg Phe Arg Ser Ser Pro Pro Asp 
                245                 250                 255     
Ser Glu Tyr Ile Thr Arg Ile Val Ser Arg Cys Leu Ile Asn Ser Gln 
            260                 265                 270         
Glu Lys Leu Ile Asn Ser Ser Phe Phe Ala Glu Gly Asn Asp Lys Ala 
        275                 280                 285             
Leu Arg Phe Ser Lys Asn Ala Glu Glu Cys Ser Leu Ala Val Glu Arg 
    290                 295                 300                 
Ala Leu Asn Gln Tyr Arg Ala Glu Asp Asn Leu Arg Asp Leu Asn Asp 
305                 310                 315                 320 
His Lys Ser Thr Ile Gln Leu Pro Pro Trp Leu Ser Tyr His Asp Val 
                325                 330                 335     
Asp Gly Lys Asp Leu Cys Pro Leu Gln Gly Leu Asp Val Arg Gly Asp 
            340                 345                 350         
His Pro Met Cys Asn Leu Trp Arg Glu Val Val Thr Ser Ala Asn Leu 
        355                 360                 365             
Glu Glu Ile Glu Arg Met His Asp Asp Ala Ala Ala Glu Leu Glu Phe 
    370                 375                 380                 
Ala Leu Ser Gly Val Lys Asp Arg Pro Asp Glu Arg Asn Arg Tyr His 
385                 390                 395                 400 
Arg Val His Leu Asn Met Gly Ser Asp Asp Ser Val Tyr Ile Ala Ala 
                405                 410                 415     
Leu Gly Val Asn Gly Lys Lys His Lys Ala Asp Thr Leu Val Gln Gln 
            420                 425                 430         
Met Arg Asp Arg Ser Lys Gln Pro Phe Ser Pro Asp His Asp Val Asp 
        435                 440                 445             
His Ile Ser Glu Phe Leu Ser Ala Cys Ser Ser Asp Leu Trp Ala Thr 
    450                 455                 460                 
Asp Glu Asp Leu Tyr Ser Pro Leu Ser Cys Asp Lys Glu Leu Arg Leu 
465                 470                 475                 480 
Ala Ala Gln Arg Ile His Gln Pro Ser Leu Ser Glu Arg Gly Phe Asn 
                485                 490                 495     
Glu Ile Ile Thr Glu His Tyr Lys Phe Met Gly Ser Arg Ile Gly Ser 
            500                 505                 510         
Trp Cys Gln Met Val Ser Leu Ile Gly Ala Glu Leu Ser Ala Ser Val 
        515                 520                 525             
Lys Gln His Val Lys Pro Asn Tyr Phe Val Ile Lys Arg Leu Leu Gly 
    530                 535                 540                 
Ser Gly Ile Phe Leu Leu Ile Lys Pro Thr Ser Ser Lys Ser His Ile 
545                 550                 555                 560 
Phe Val Ser Phe Ala Ile Lys Arg Ser Cys Trp Ala Phe Asp Leu Ser 
                565                 570                 575     
Thr Ser Arg Val Phe Lys Pro Tyr Ile Asp Ala Gly Asp Leu Leu Val 
            580                 585                 590         
Thr Asp Phe Val Ser Tyr Lys Leu Ser Lys Leu Thr Asn Leu Cys Lys 
        595                 600                 605             
Cys Val Ser Leu Met Glu Ser Ser Phe Ser Phe Trp Ala Glu Ala Phe 
    610                 615                 620                 
Gly Ile Pro Ser Trp Asn Phe Val Gly Asp Leu Phe Arg Ser Ser Asp 
625                 630                 635                 640 
Ser Ala Ala Met Asp Ala Ser Tyr Met Gly Lys Leu Ser Leu Leu Thr 
                645                 650                 655     
Leu Leu Glu Asp Lys Ala Ala Thr Glu Glu Leu Gln Thr Ile Ala Arg 
            660                 665                 670         
Tyr Ile Ile Met Glu Gly Phe Val Ser Pro Pro Glu Ile Pro Lys Pro 
        675                 680                 685             
His Lys Met Thr Ser Lys Phe Pro Lys Val Leu Arg Ser Glu Leu Gln 
    690                 695                 700                 
Val Tyr Leu Leu Asn Cys Leu Cys Arg Thr Ile Gln Arg Ile Ala Gly 
705                 710                 715                 720 
Glu Pro Phe Ile Leu Lys Lys Lys Asp Gly Ser Ile Ser Trp Gly Gly 
                725                 730                 735     
Met Phe Asn Pro Phe Ser Gly Arg Pro Leu Leu Asp Met Gln Pro Leu 
            740                 745                 750         
Ile Ser Cys Cys Tyr Asn Gly Tyr Phe Lys Asn Lys Glu Glu Glu Thr 
        755                 760                 765             
Glu Pro Ser Ser Leu Ser Gly Met Tyr Lys Lys Ile Ile Glu Leu Glu 
    770                 775                 780                 
His Leu Arg Pro Gln Ser Asp Ala Phe Leu Gly Tyr Lys Asp Pro Glu 
785                 790                 795                 800 
Leu Pro Arg Met His Glu Phe Ser Val Ser Tyr Leu Lys Glu Ala Cys 
                805                 810                 815     
Asn His Ala Lys Leu Val Leu Arg Ser Leu Tyr Gly Gln Asn Phe Met 
            820                 825                 830         
Glu Gln Ile Asp Asn Gln Ile Ile Arg Glu Leu Ser Gly Leu Thr Leu 
        835                 840                 845             
Glu Arg Leu Ala Thr Leu Lys Ala Thr Ser Asn Phe Asn Glu Asn Trp 
    850                 855                 860                 
Tyr Val Tyr Lys Asp Val Ala Asp Lys Asn Tyr Thr Arg Asp Lys Leu 
865                 870                 875                 880 
Leu Val Lys Met Ser Lys Tyr Ala Ser Glu Gly Lys Ser Leu Ala Ile 
                885                 890                 895     
Gln Lys Phe Glu Asp Cys Met Arg Gln Ile Glu Ser Gln Gly Cys Met 
            900                 905                 910         
His Ile Cys Leu Phe Lys Lys Gln Gln His Gly Gly Leu Arg Glu Ile 
        915                 920                 925             
Tyr Val Met Gly Ala Glu Glu Arg Ile Val Gln Ser Val Val Glu Thr 
    930                 935                 940                 
Ile Ala Arg Ser Ile Gly Lys Phe Phe Ala Ser Asp Thr Leu Cys Asn 
945                 950                 955                 960 
Pro Pro Asn Lys Val Lys Ile Pro Glu Thr His Gly Ile Arg Ala Arg 
                965                 970                 975     
Lys Gln Cys Lys Gly Pro Val Trp Thr Cys Ala Thr Ser Asp Asp Ala 
            980                 985                 990         
Arg Lys Trp Asn Gln Gly His Phe Val Thr Lys Phe Ala Leu Met Leu 
        995                 1000                1005            
Cys Glu Phe Thr Ser Pro Lys Trp Trp Pro Leu Ile Ile Arg Gly Cys 
    1010                1015                1020                
Ser Met Phe Thr Arg Lys Arg Met Met Met Asn Leu Asn Tyr Leu Lys 
1025                1030                1035                1040
Ile Leu Asp Gly His Arg Glu Leu Asp Ile Arg Asp Asp Phe Val Met 
                1045                1050                1055    
Asp Leu Phe Lys Ala Tyr His Gly Glu Ala Glu Val Pro Trp Ala Phe 
            1060                1065                1070        
Lys Gly Lys Thr Tyr Leu Glu Thr Thr Thr Gly Met Met Gln Gly Ile 
        1075                1080                1085            
Leu His Tyr Thr Ser Ser Leu Leu His Thr Ile His Gln Glu Tyr Ile 
    1090                1095                1100                
Arg Ser Leu Ser Phe Lys Ile Phe Asn Leu Lys Val Ala Pro Glu Met 
1105                1110                1115                1120
Ser Lys Ser Leu Val Cys Asp Met Met Gln Gly Ser Asp Asp Ser Ser 
                1125                1130                1135    
Met Leu Ile Ser Phe Pro Ala Asp Asp Glu Lys Val Leu Thr Arg Cys 
            1140                1145                1150        
Lys Val Ala Ala Ala Ile Cys Phe Arg Met Lys Lys Glu Leu Gly Val 
        1155                1160                1165            
Tyr Leu Ala Ile Tyr Pro Ser Glu Lys Ser Thr Ala Asn Thr Asp Phe 
    1170                1175                1180                
Val Met Glu Tyr Asn Ser Glu Phe Tyr Phe His Thr Gln His Val Arg 
1185                1190                1195                1200
Pro Thr Ile Arg Trp Ile Ala Ala Cys Cys Ser Leu Pro Glu Val Glu 
                1205                1210                1215    
Thr Leu Val Ala Arg Gln Glu Glu Ala Ser Asn Leu Met Thr Ser Val 
            1220                1225                1230        
Thr Glu Gly Gly Gly Ser Phe Ser Leu Ala Ala Met Ile Gln Gln Ala 
        1235                1240                1245            
Gln Cys Thr Leu His Tyr Met Leu Met Gly Met Gly Val Ser Glu Leu 
    1250                1255                1260                
Phe Leu Glu Tyr Lys Lys Ala Val Leu Lys Trp Asn Asp Pro Gly Leu 
1265                1270                1275                1280
Gly Phe Phe Leu Leu Asp Asn Pro Tyr Ala Cys Gly Leu Gly Gly Phe 
                1285                1290                1295    
Arg Phe Asn Leu Phe Lys Ala Ile Thr Arg Thr Asp Leu Gln Lys Leu 
            1300                1305                1310        
Tyr Ala Phe Phe Met Lys Lys Val Lys Gly Ser Ala Ala Arg Asp Trp 
        1315                1320                1325            
Ala Asp Glu Asp Val Thr Ile Pro Glu Thr Cys Ser Val Ser Pro Gly 
    1330                1335                1340                
Gly Ala Leu Ile Leu Ser Ser Ser Leu Lys Trp Gly Ser Arg Lys Lys 
1345                1350                1355                1360
Phe Gln Lys Leu Arg Asp Arg Leu Asn Ile Pro Glu Asn Trp Ile Glu 
                1365                1370                1375    
Leu Ile Asn Glu Asn Pro Glu Val Leu Tyr Arg Ala Pro Arg Thr Gly 
            1380                1385                1390        
Pro Glu Ile Leu Leu Arg Ile Ala Glu Lys Val His Ser Pro Gly Val 
        1395                1400                1405            
Val Ser Ser Leu Ser Ser Gly Asn Ala Val Cys Lys Val Met Ala Ser 
    1410                1415                1420                
Ala Val Tyr Phe Leu Ser Ala Thr Ile Phe Glu Asp Thr Gly Arg Pro 
1425                1430                1435                1440
Glu Phe Asn Phe Leu Glu Asp Ser Lys Tyr Ser Leu Leu Gln Lys Met 
                1445                1450                1455    
Ala Ala Tyr Ser Gly Phe His Gly Phe Asn Asp Met Glu Pro Glu Asp 
            1460                1465                1470        
Ile Leu Phe Leu Phe Pro Asn Ile Glu Glu Leu Glu Ser Leu Asp Ser 
        1475                1480                1485            
Ile Val Tyr Asn Lys Gly Glu Ile Asp Ile Ile Pro Arg Val Asn Ile 
    1490                1495                1500                
Arg Asp Ala Thr Gln Thr Arg Val Thr Ile Phe Asn Glu Gln Lys Thr 
1505                1510                1515                1520
Leu Arg Thr Ser Pro Glu Lys Leu Val Ser Asp Lys Trp Phe Gly Thr 
                1525                1530                1535    
Gln Lys Ser Arg Ile Gly Lys Thr Thr Phe Leu Ala Glu Trp Glu Lys 
            1540                1545                1550        
Leu Lys Lys Ile Val Lys Trp Leu Glu Asp Thr Pro Glu Ala Thr Leu 
        1555                1560                1565            
Ala His Thr Pro Leu Asn Asn His Ile Gln Val Arg Asn Phe Phe Ala 
    1570                1575                1580                
Arg Met Glu Ser Lys Pro Arg Thr Val Arg Ile Thr Gly Ala Pro Val 
1585                1590                1595                1600
Lys Lys Arg Ser Gly Val Ser Lys Ile Ala Met Val Ile Arg Asp Asn 
                1605                1610                1615    
Phe Ser Arg Met Gly His Leu Arg Gly Val Glu Asp Leu Ala Gly Phe 
            1620                1625                1630        
Thr Arg Ser Val Ser Ala Glu Ile Leu Lys His Phe Leu Phe Cys Ile 
        1635                1640                1645            
Leu Gln Gly Pro Tyr Ser Glu Ser Tyr Lys Leu Gln Leu Ile Tyr Arg 
    1650                1655                1660                
Val Leu Ser Ser Val Ser Asn Val Glu Ile Lys Glu Ser Asp Gly Lys 
1665                1670                1675                1680
Thr Lys Thr Asn Leu Ile Gly Ile Leu Gln Arg Phe Leu Asp Gly Asp 
                1685                1690                1695    
His Val Val Pro Ile Ile Glu Glu Met Gly Ala Gly Thr Val Gly Gly 
            1700                1705                1710        
Phe Ile Lys Arg Gln Gln Ser Lys Val Val Gln Asn Lys Val Val Tyr 
        1715                1720                1725            
Tyr Gly Val Gly Ile Trp Arg Gly Phe Met Asp Gly Tyr Gln Val His 
    1730                1735                1740                
Leu Glu Ile Glu Asn Asp Ile Gly Gln Pro Pro Arg Leu Arg Asn Val 
1745                1750                1755                1760
Thr Thr Asn Cys Gln Ser Ser Pro Trp Asp Leu Ser Ile Pro Ile Arg 
                1765                1770                1775    
Gln Trp Ala Glu Asp Met Gly Val Thr Asn Asn Gln Asp Tyr Ser Ser 
            1780                1785                1790        
Lys Ser Ser Arg Gly Ala Arg Tyr Trp Met His Ser Phe Arg Met Gln 
        1795                1800                1805            
Gly Pro Ser Lys Pro Phe Gly Cys Pro Val Tyr Ile Ile Lys Gly Asp 
    1810                1815                1820                
Met Ser Asp Val Ile Arg Leu Arg Lys Glu Glu Val Glu Met Lys Val 
1825                1830                1835                1840
Arg Gly Ser Thr Leu Asn Leu Tyr Thr Lys His His Ser His Gln Asp 
                1845                1850                1855    
Leu His Ile Leu Ser Tyr Thr Ala Ser Asp Asn Asp Leu Ser Pro Gly 
            1860                1865                1870        
Ile Phe Lys Ser Ile Ser Asp Glu Gly Val Ala Gln Ala Leu Gln Leu 
        1875                1880                1885            
Phe Glu Arg Glu Pro Ser Asn Cys Trp Val Arg Cys Glu Ser Val Ala 
    1890                1895                1900                
Pro Lys Phe Ile Ser Ala Ile Leu Glu Ile Cys Glu Gly Lys Arg Gln 
1905                1910                1915                1920
Ile Lys Gly Ile Asn Arg Thr Arg Leu Ser Glu Ile Val Arg Ile Cys 
                1925                1930                1935    
Ser Glu Ser Ser Leu Arg Ser Lys Val Gly Ser Met Phe Ser Phe Val 
            1940                1945                1950        
Ala Asn Val Glu Glu Ala His Asp Val Asp Tyr Asp Ala Leu Met Asp 
        1955                1960                1965            
Leu Met Ile Glu Asp Ala Lys Asn Asn Ala Phe Ser His Val Val Asp 
    1970                1975                1980                
Cys Ile Glu Leu Asp Val Ser Gly Pro Tyr Glu Met Glu Ser Phe Asp 
1985                1990                1995                2000
Thr Ser Asp Val Asn Leu Phe Gly Pro Ala His Tyr Lys Asp Ile Ser 
                2005                2010                2015    
Ser Leu Ser Met Ile Ala His Pro Leu Met Asp Lys Phe Val Asp Tyr 
            2020                2025                2030        
Ala Ile Ser Lys Met Gly Arg Ala Ser Val Arg Lys Val Leu Glu Thr 
        2035                2040                2045            
Gly Arg Cys Ser Ser Lys Asp Tyr Asp Leu Ser Lys Val Leu Phe Arg 
    2050                2055                2060                
Thr Leu Gln Arg Pro Glu Glu Ser Ile Arg Ile Asp Asp Leu Glu Leu 
2065                2070                2075                2080
Tyr Glu Glu Thr Asp Val Ala Asp Asp Met Leu Gly 
                2085                2090        

<210> 55
<211> 1197
<212> PRT
<213> Secuencia Artificial


<220> 
<223> (Poli)proteína M virus VFVR ZH548

<400> 55
Met Tyr Val Leu Leu Thr Ile Leu Ile Ser Val Leu Val Cys Glu Ala 
1               5                   10                  15      
Val Ile Arg Val Ser Leu Ser Ser Thr Arg Glu Glu Thr Cys Phe Gly 
            20                  25                  30          
Asp Ser Thr Asn Pro Glu Met Ile Glu Gly Ala Trp Asp Ser Leu Arg 
        35                  40                  45              
Glu Glu Glu Met Pro Glu Glu Leu Ser Cys Ser Ile Ser Gly Ile Arg 
    50                  55                  60                  
Glu Val Lys Thr Ser Ser Gln Glu Leu Tyr Arg Ala Leu Lys Ala Ile 
65                  70                  75                  80  
Ile Ala Ala Asp Gly Leu Asn Asn Ile Thr Cys His Gly Lys Asp Pro 
                85                  90                  95      
Glu Asp Lys Ile Ser Leu Ile Lys Gly Pro Pro His Lys Lys Arg Val 
            100                 105                 110         
Gly Ile Val Arg Cys Glu Arg Arg Arg Asp Ala Lys Gln Ile Gly Arg 
        115                 120                 125             
Glu Thr Met Ala Gly Ile Ala Met Thr Val Leu Pro Ala Leu Ala Val 
    130                 135                 140                 
Phe Ala Leu Ala Pro Val Val Phe Ala Glu Asp Pro His Leu Arg Asn 
145                 150                 155                 160 
Arg Pro Gly Lys Gly His Asn Tyr Ile Asp Gly Met Thr Gln Glu Asp 
                165                 170                 175     
Ala Thr Cys Lys Pro Val Thr Tyr Ala Gly Ala Cys Ser Ser Phe Asp 
            180                 185                 190         
Val Leu Leu Glu Lys Gly Lys Phe Pro Leu Phe Gln Ser Tyr Ala His 
        195                 200                 205             
His Arg Thr Leu Leu Glu Ala Val His Asp Thr Ile Ile Ala Lys Ala 
    210                 215                 220                 
Asp Pro Pro Ser Cys Asp Leu Leu Ser Ala His Gly Asn Pro Cys Met 
225                 230                 235                 240 
Lys Glu Lys Leu Val Met Lys Thr His Cys Pro Asn Asp Tyr Gln Ser 
                245                 250                 255     
Ala His Tyr Leu Asn Asn Asp Gly Lys Met Ala Ser Val Lys Cys Pro 
            260                 265                 270         
Pro Lys Tyr Glu Leu Thr Glu Asp Cys Asn Phe Cys Arg Gln Met Thr 
        275                 280                 285             
Gly Ala Ser Leu Lys Lys Gly Ser Tyr Pro Leu Gln Asp Leu Phe Cys 
    290                 295                 300                 
Gln Ser Ser Glu Asp Asp Gly Ser Lys Leu Lys Thr Lys Met Lys Gly 
305                 310                 315                 320 
Val Cys Glu Val Gly Val Gln Ala Leu Lys Lys Cys Asp Gly Gln Leu 
                325                 330                 335     
Ser Thr Ala His Glu Val Val Pro Phe Ala Val Phe Lys Asn Ser Lys 
            340                 345                 350         
Lys Val Tyr Leu Asp Lys Leu Asp Leu Lys Thr Glu Glu Asn Leu Leu 
        355                 360                 365             
Pro Asp Ser Phe Val Cys Phe Glu His Lys Gly Gln Tyr Lys Gly Thr 
    370                 375                 380                 
Met Asp Ser Gly Gln Thr Lys Arg Glu Leu Lys Ser Phe Asp Ile Ser 
385                 390                 395                 400 
Gln Cys Pro Lys Ile Gly Gly His Gly Ser Lys Lys Cys Thr Gly Asp 
                405                 410                 415     
Ala Ala Phe Cys Ser Ala Tyr Glu Cys Thr Ala Gln Tyr Ala Asn Ala 
            420                 425                 430         
Tyr Cys Ser His Ala Asn Gly Ser Gly Ile Val Gln Ile Gln Val Ser 
        435                 440                 445             
Gly Val Trp Lys Lys Pro Leu Cys Val Gly Tyr Glu Arg Val Val Val 
    450                 455                 460                 
Lys Arg Glu Leu Ser Ala Lys Pro Ile Gln Arg Val Glu Pro Cys Thr 
465                 470                 475                 480 
Thr Cys Ile Thr Lys Cys Glu Pro His Gly Leu Val Val Arg Ser Thr 
                485                 490                 495     
Gly Phe Lys Ile Ser Ser Ala Val Ala Cys Ala Ser Gly Val Cys Val 
            500                 505                 510         
Thr Gly Ser Gln Ser Pro Ser Thr Glu Ile Thr Leu Lys Tyr Pro Gly 
        515                 520                 525             
Ile Ser Gln Ser Ser Gly Gly Asp Ile Gly Val His Met Ala His Asp 
    530                 535                 540                 
Asp Gln Ser Val Ser Ser Lys Ile Val Ala His Cys Pro Pro Gln Asp 
545                 550                 555                 560 
Pro Cys Leu Val His Asp Cys Ile Val Cys Ala His Gly Leu Ile Asn 
                565                 570                 575     
Tyr Gln Cys His Thr Ala Leu Ser Ala Phe Val Val Val Phe Val Phe 
            580                 585                 590         
Ser Ser Ile Ala Ile Ile Cys Leu Ala Ile Leu Tyr Arg Val Leu Lys 
        595                 600                 605             
Cys Leu Lys Ile Ala Pro Arg Lys Val Leu Asn Pro Leu Met Trp Ile 
    610                 615                 620                 
Thr Ala Phe Ile Arg Trp Ile Tyr Lys Lys Met Val Ala Arg Val Ala 
625                 630                 635                 640 
Asp Asn Ile Asn Gln Val Asn Arg Glu Ile Gly Trp Met Glu Gly Gly 
                645                 650                 655     
Gln Leu Val Leu Gly Asn Pro Ala Pro Ile Pro Arg His Ala Pro Ile 
            660                 665                 670         
Pro Arg Tyr Ser Thr Tyr Leu Met Leu Leu Leu Ile Val Ser Tyr Ala 
        675                 680                 685             
Ser Ala Cys Ser Glu Leu Ile Gln Ala Ser Ser Arg Ile Thr Thr Cys 
    690                 695                 700                 
Ser Thr Glu Gly Val Asn Thr Lys Cys Arg Leu Ser Gly Thr Ala Leu 
705                 710                 715                 720 
Ile Arg Ala Gly Ser Val Gly Ala Glu Ala Cys Leu Met Leu Lys Gly 
                725                 730                 735     
Val Lys Glu Asp Gln Thr Lys Phe Leu Lys Ile Lys Thr Val Ser Ser 
            740                 745                 750         
Glu Leu Ser Cys Arg Glu Gly Gln Ser Tyr Trp Thr Gly Ser Phe Ser 
        755                 760                 765             
Pro Lys Cys Leu Ser Ser Arg Arg Cys His Leu Val Gly Glu Cys His 
    770                 775                 780                 
Val Asn Arg Cys Leu Ser Trp Arg Asp Asn Glu Thr Ser Ala Glu Phe 
785                 790                 795                 800 
Ser Phe Val Gly Glu Ser Thr Thr Met Arg Glu Asn Lys Cys Phe Glu 
                805                 810                 815     
Gln Cys Gly Gly Trp Gly Cys Gly Cys Phe Asn Val Asn Pro Ser Cys 
            820                 825                 830         
Leu Phe Val His Thr Tyr Leu Gln Ser Val Arg Lys Glu Ala Leu Arg 
        835                 840                 845             
Val Phe Asn Cys Ile Asp Trp Val His Lys Leu Thr Leu Glu Ile Thr 
    850                 855                 860                 
Asp Phe Asp Gly Ser Val Ser Thr Ile Asp Leu Gly Ala Ser Ser Ser 
865                 870                 875                 880 
Arg Phe Thr Asn Trp Gly Ser Val Ser Leu Ser Leu Asp Ala Glu Gly 
                885                 890                 895     
Ile Ser Gly Ser Asn Ser Phe Ser Phe Ile Glu Ser Pro Gly Lys Gly 
            900                 905                 910         
Tyr Ala Ile Val Asp Glu Pro Phe Ser Glu Ile Pro Arg Gln Gly Phe 
        915                 920                 925             
Leu Gly Glu Ile Arg Cys Asn Ser Glu Ser Ser Val Leu Ser Ala His 
    930                 935                 940                 
Glu Ser Cys Leu Arg Ala Pro Asn Leu Ile Ser Tyr Lys Pro Met Ile 
945                 950                 955                 960 
Asp Gln Leu Glu Cys Thr Thr Asn Leu Ile Asp Pro Phe Val Val Phe 
                965                 970                 975     
Glu Arg Gly Ser Leu Pro Gln Thr Arg Asn Asp Lys Thr Phe Ala Ala 
            980                 985                 990         
Ser Lys Gly Asn Arg Gly Val Gln Ala Phe Ser Lys Gly Ser Val Gln 
        995                 1000                1005            
Ala Asp Leu Thr Leu Met Phe Asp Asn Phe Glu Val Asp Phe Val Gly 
    1010                1015                1020                
Ala Ala Val Ser Cys Asp Ala Ala Phe Leu Asn Leu Thr Gly Cys Tyr 
1025                1030                1035                1040
Ser Cys Asn Ala Gly Ala Arg Val Cys Leu Ser Ile Thr Ser Thr Gly 
                1045                1050                1055    
Thr Gly Ser Leu Ser Ala His Asn Lys Asp Gly Ser Leu His Ile Val 
            1060                1065                1070        
Leu Pro Ser Glu Asn Gly Thr Lys Asp Gln Cys Gln Ile Leu His Phe 
        1075                1080                1085            
Thr Val Pro Glu Val Glu Glu Glu Phe Met Tyr Ser Cys Asp Gly Asp 
    1090                1095                1100                
Glu Arg Pro Leu Leu Val Lys Gly Thr Leu Ile Ala Ile Asp Pro Phe 
1105                1110                1115                1120
Asp Asp Arg Arg Glu Ala Gly Gly Glu Ser Thr Val Val Asn Pro Lys 
                1125                1130                1135    
Ser Gly Ser Trp Asn Phe Phe Asp Trp Phe Ser Gly Leu Met Ser Trp 
            1140                1145                1150        
Phe Gly Gly Pro Leu Lys Thr Ile Leu Leu Ile Cys Leu Tyr Val Ala 
        1155                1160                1165            
Leu Ser Ile Gly Leu Phe Phe Leu Leu Ile Tyr Leu Gly Arg Thr Gly 
    1170                1175                1180                
Leu Ser Lys Met Trp Leu Ala Ala Thr Lys Lys Ala Ser 
1185                1190                1195        

<210> 56
<211> 265
<212> PRT
<213> Secuencia Artificial


<220> 
<223> Proteína NSs virus VFVR ZH548

<400> 56
Met Asp Tyr Phe Pro Val Ile Ser Val Asp Leu Gln Ser Gly Arg Arg 
1               5                   10                  15      
Val Val Ser Val Glu Tyr Phe Arg Gly Asp Gly Pro Pro Arg Ile Pro 
            20                  25                  30          
Tyr Ser Met Val Gly Pro Cys Cys Val Phe Leu Met His His Arg Pro 
        35                  40                  45              
Ser His Glu Val Arg Leu Arg Phe Ser Asp Phe Tyr Asn Val Gly Glu 
    50                  55                  60                  
Phe Pro Tyr Arg Val Gly Leu Gly Asp Phe Ala Ser Asn Val Ala Pro 
65                  70                  75                  80  
Pro Pro Ala Lys Pro Phe Gln Arg Leu Ile Asp Leu Ile Gly His Met 
                85                  90                  95      
Thr Leu Ser Asp Phe Thr Arg Phe Pro Asn Leu Lys Glu Ala Ile Ser 
            100                 105                 110         
Trp Pro Leu Gly Glu Pro Ser Leu Ala Phe Phe Asp Leu Ser Ser Thr 
        115                 120                 125             
Arg Val His Arg Asn Asp Asp Ile Arg Arg Asp Gln Ile Ala Thr Leu 
    130                 135                 140                 
Ala Met Arg Ser Cys Lys Ile Thr Asn Asp Leu Glu Asp Ser Phe Val 
145                 150                 155                 160 
Gly Leu His Arg Met Ile Ala Thr Glu Ala Ile Leu Arg Gly Ile Asp 
                165                 170                 175     
Leu Cys Leu Leu Pro Gly Phe Asp Leu Met Tyr Glu Val Ala His Val 
            180                 185                 190         
Gln Cys Val Arg Leu Leu Gln Ala Ala Lys Glu Asp Ile Ser Asn Ala 
        195                 200                 205             
Val Val Pro Asn Ser Ala Leu Ile Val Leu Met Glu Glu Ser Leu Met 
    210                 215                 220                 
Leu Arg Ser Ser Leu Pro Ser Met Met Gly Arg Asn Asn Trp Ile Pro 
225                 230                 235                 240 
Val Ile Pro Pro Ile Pro Asp Val Glu Met Glu Ser Glu Glu Glu Ser 
                245                 250                 255     
Asp Asp Asp Gly Phe Val Glu Val Asp 
            260                 265 

<210> 57
<211> 245
<212> PRT
<213> Secuencia Artificial


<220> 
<223> Proteína N virus VFVR ZH548

<400> 57
Met Asp Asn Tyr Gln Glu Leu Ala Ile Gln Phe Ala Ala Gln Ala Val 
1               5                   10                  15      
Asp Arg Asn Glu Ile Glu Gln Trp Val Arg Glu Phe Ala Tyr Gln Gly 
            20                  25                  30          
Phe Asp Ala Arg Arg Val Ile Glu Leu Leu Lys Gln Tyr Gly Gly Ala 
        35                  40                  45              
Asp Trp Glu Lys Asp Ala Lys Lys Met Ile Val Leu Ala Leu Thr Arg 
    50                  55                  60                  
Gly Asn Lys Pro Arg Arg Met Met Met Lys Met Ser Lys Glu Gly Lys 
65                  70                  75                  80  
Ala Thr Val Glu Ala Leu Ile Asn Lys Tyr Lys Leu Lys Glu Gly Asn 
                85                  90                  95      
Pro Ser Arg Asp Glu Leu Thr Leu Ser Arg Val Ala Ala Ala Leu Ala 
            100                 105                 110         
Gly Trp Thr Cys Gln Ala Leu Val Val Leu Ser Glu Trp Leu Pro Val 
        115                 120                 125             
Thr Gly Thr Thr Met Asp Gly Leu Ser Pro Ala Tyr Pro Arg His Met 
    130                 135                 140                 
Met His Pro Ser Phe Ala Gly Met Val Asp Pro Ser Leu Pro Gly Asp 
145                 150                 155                 160 
Tyr Leu Arg Ala Ile Leu Asp Ala His Ser Leu Tyr Leu Leu Gln Phe 
                165                 170                 175     
Ser Arg Val Ile Asn Pro Asn Leu Arg Gly Arg Thr Lys Glu Glu Val 
            180                 185                 190         
Ala Ala Thr Phe Thr Gln Pro Met Asn Ala Ala Val Asn Ser Asn Phe 
        195                 200                 205             
Ile Ser His Glu Lys Arg Arg Glu Phe Leu Lys Ala Phe Gly Leu Val 
    210                 215                 220                 
Asp Ser Asn Gly Lys Pro Ser Ala Ala Val Met Ala Ala Ala Gln Ala 
225                 230                 235                 240 
Tyr Lys Thr Ala Ala 
                245 

