               SEQUENCE LISTING

<110> INOTREM
      DERIVE Marc
      SALCEDO-MAGGUILLI Margarita
      GARAUD Jean-Jacques
      LAMBDEN Simon
      OLIVIER Aurélie

<120> TREM-1 INHIBITOR FOR USE IN THE TREATMENT OF A SUBJECT SUFFERING FROM A CORONAVIRUS INFECTION

<130> IBIO-1571/PCT

<150> EP20305603.1
<151> 2020-06-05

<160> 21

<170> BiSSAP 1.3.6

<210> 1
<211> 234
<212> PRT
<213> Homo sapiens


<400> 1
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      
Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          
Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              
Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  
Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  
Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      
Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         
Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             
Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 
Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 
Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     
Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         
Thr Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile 
        195                 200                 205             
Leu Leu Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu 
    210                 215                 220                 
Phe Ala Val Thr Leu Arg Ser Phe Val Pro 
225                 230                 

<210> 2
<211> 150
<212> PRT
<213> Homo sapiens


<400> 2
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      
Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          
Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              
Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  
Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  
Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      
Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         
Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             
Ile Arg Leu Val Val Thr Lys Gly Phe Arg Cys Ser Thr Leu Ser Phe 
    130                 135                 140                 
Ser Trp Leu Val Asp Ser 
145                 150 

<210> 3
<211> 225
<212> PRT
<213> Homo sapiens


<400> 3
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      
Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          
Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              
Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  
Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  
Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      
Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         
Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             
Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 
Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 
Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     
Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         
Thr Asn Val Thr Asp Ile Ile Arg Tyr Ser Phe Gln Val Pro Gly Pro 
        195                 200                 205             
Leu Val Trp Thr Leu Ser Pro Leu Phe Pro Ser Leu Cys Ala Glu Arg 
    210                 215                 220                 
Met 
225 

<210> 4
<211> 250
<212> PRT
<213> Homo sapiens


<400> 4
Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      
Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          
Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              
Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  
Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  
Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      
Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         
Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             
Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 
Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 
Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     
Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         
Thr Asn Val Thr Asp Ile Ile Arg Glu Lys Ser Met Thr Phe Gly Ile 
        195                 200                 205             
Arg Arg Leu Asp Val Glu Ser His Pro Leu Pro Pro Leu His Thr Gly 
    210                 215                 220                 
His Phe Arg Ile Ser Gln Phe Phe Ser Gln Ala Gly Thr Gln Ser Leu 
225                 230                 235                 240 
His Ser Cys Tyr Lys Gly Lys Pro Thr Pro 
                245                 250 

<210> 5
<211> 185
<212> PRT
<213> Homo sapiens


<400> 5
Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys Glu Gly Gln Thr 
1               5                   10                  15      
Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe Ala Ser Ser Gln 
            20                  25                  30          
Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro Lys Thr Leu Ala 
        35                  40                  45              
Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val Gln Val Gly Arg 
    50                  55                  60                  
Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu Arg Val Arg Met 
65                  70                  75                  80  
Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln Cys Val Ile Tyr 
                85                  90                  95      
Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg Ile Arg Leu Val 
            100                 105                 110         
Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn Glu Asn Ser Thr 
        115                 120                 125             
Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys Ala Leu Cys Pro 
    130                 135                 140                 
Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro Pro Lys Ser Thr 
145                 150                 155                 160 
Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu Thr Asn Val Thr 
                165                 170                 175     
Asp Ile Ile Arg Val Pro Val Phe Asn 
            180                 185 

<210> 6
<211> 175
<212> PRT
<213> Homo sapiens


<400> 6
Leu Lys Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu 
1               5                   10                  15      
Lys Phe Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu 
            20                  25                  30          
Met Pro Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His 
        35                  40                  45              
Pro Val Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly 
    50                  55                  60                  
Leu Leu Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu 
65                  70                  75                  80  
Tyr Gln Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe 
                85                  90                  95      
Asp Arg Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly 
            100                 105                 110         
Ser Asn Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr 
        115                 120                 125             
Thr Lys Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln 
    130                 135                 140                 
Ala Pro Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile 
145                 150                 155                 160 
Asn Leu Thr Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn 
                165                 170                 175 

<210> 7
<211> 107
<212> PRT
<213> Homo sapiens


<400> 7
Leu Lys Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu 
1               5                   10                  15      
Lys Phe Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu 
            20                  25                  30          
Met Pro Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His 
        35                  40                  45              
Pro Val Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly 
    50                  55                  60                  
Leu Leu Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu 
65                  70                  75                  80  
Tyr Gln Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe 
                85                  90                  95      
Asp Arg Ile Arg Leu Val Val Thr Lys Gly Phe 
            100                 105         

<210> 8
<211> 311
<212> PRT
<213> Homo sapiens


<400> 8
Met Gly Leu Thr Leu Leu Leu Leu Leu Leu Leu Gly Leu Glu Gly Gln 
1               5                   10                  15      
Gly Ile Val Gly Ser Leu Pro Glu Val Leu Gln Ala Pro Val Gly Ser 
            20                  25                  30          
Ser Ile Leu Val Gln Cys His Tyr Arg Leu Gln Asp Val Lys Ala Gln 
        35                  40                  45              
Lys Val Trp Cys Arg Phe Leu Pro Glu Gly Cys Gln Pro Leu Val Ser 
    50                  55                  60                  
Ser Ala Val Asp Arg Arg Ala Pro Ala Gly Arg Arg Thr Phe Leu Thr 
65                  70                  75                  80  
Asp Leu Gly Gly Gly Leu Leu Gln Val Glu Met Val Thr Leu Gln Glu 
                85                  90                  95      
Glu Asp Ala Gly Glu Tyr Gly Cys Met Val Asp Gly Ala Arg Gly Pro 
            100                 105                 110         
Gln Ile Leu His Arg Val Ser Leu Asn Ile Leu Pro Pro Glu Glu Glu 
        115                 120                 125             
Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala Phe Ser Asp 
    130                 135                 140                 
Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln Asp Glu Lys Ser 
145                 150                 155                 160 
Ile Pro Leu Ile Trp Gly Ala Val Leu Leu Val Gly Leu Leu Val Ala 
                165                 170                 175     
Ala Val Val Leu Phe Ala Val Met Ala Lys Arg Lys Gln Gly Asn Arg 
            180                 185                 190         
Leu Gly Val Cys Gly Arg Phe Leu Ser Ser Arg Val Ser Gly Met Asn 
        195                 200                 205             
Pro Ser Ser Val Val His His Val Ser Asp Ser Gly Pro Ala Ala Glu 
    210                 215                 220                 
Leu Pro Leu Asp Val Pro His Ile Arg Leu Asp Ser Pro Pro Ser Phe 
225                 230                 235                 240 
Asp Asn Thr Thr Tyr Thr Ser Leu Pro Leu Asp Ser Pro Ser Gly Lys 
                245                 250                 255     
Pro Ser Leu Pro Ala Pro Ser Ser Leu Pro Pro Leu Pro Pro Lys Val 
            260                 265                 270         
Leu Val Cys Ser Lys Pro Val Thr Tyr Ala Thr Val Ile Phe Pro Gly 
        275                 280                 285             
Gly Asn Lys Gly Gly Gly Thr Ser Cys Gly Pro Ala Gln Asn Pro Pro 
    290                 295                 300                 
Asn Asn Gln Thr Pro Ser Ser 
305                 310     

<210> 9
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> TLT-1 peptide

<400> 9
Leu Gln Glu Glu Asp Ala Gly Glu Tyr Gly Cys Met Val Asp Gly Ala 
1               5                   10                  15      
Arg 
    

<210> 10
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> TLT-1 peptide

<400> 10
Leu Gln Glu Glu Asp Ala Gly Glu Tyr Gly Cys Met 
1               5                   10          

<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> TLT-1

<400> 11
Leu Gln Glu Glu Asp Ala 
1               5       

<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> TLT-1 peptide

<400> 12
Glu Asp Ala Gly Glu Tyr 
1               5       

<210> 13
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> TLT-1 peptide

<400> 13
Gly Glu Tyr Gly Cys Met 
1               5       

<210> 14
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 14
gtggtgacca aggggttc                                                  18


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 15
agatggatgt ggctggaagt                                                20


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 16
gtgaccaagg gtttttcagg                                                20


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 17
acaccggaac cctgatgata                                                20


<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 18
aaaggcaaga acgcctgac                                                 19


<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 19
gggactttac caagagggac                                                20


<210> 20
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> TLT-1 peptide

<400> 20
Leu Gln Glu Glu Asp Thr Gly Glu Tyr Gly Cys Val 
1               5                   10          

<210> 21
<211> 1273
<212> PRT
<213> SARS coronavirus


<220> 
<223> Spike glycoprotein

<400> 21
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      
Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          
Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              
His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  
Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  
Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      
Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         
Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             
Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 
Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 
Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     
Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         
Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             
Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 
Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 
Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     
Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         
Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             
Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 
Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     
Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         
Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             
Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 
Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 
Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     
Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         
Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             
Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 
Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 
Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     
Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         
Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             
Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 
Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 
Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     
Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         
Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             
Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 
His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 
Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     
Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         
Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             
Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 
Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 
Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     
Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         
Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             
Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 
Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 
Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     
Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         
Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             
Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 
Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 
Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     
Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         
Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             
Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 
Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 
Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     
Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         
Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val 
        995                 1000                1005            
Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu 
    1010                1015                1020                
Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val 
1025                1030                1035                1040
Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser Ala 
                1045                1050                1055    
Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln Glu 
            1060                1065                1070        
Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala His 
        1075                1080                1085            
Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe Val 
    1090                1095                1100                
Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn Thr 
1105                1110                1115                1120
Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn Thr 
                1125                1130                1135    
Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu 
            1140                1145                1150        
Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp 
        1155                1160                1165            
Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp 
    1170                1175                1180                
Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1185                1190                1195                1200
Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
                1205                1210                1215    
Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile 
            1220                1225                1230        
Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Cys Cys 
        1235                1240                1245            
Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val 
    1250                1255                1260                
Leu Lys Gly Val Lys Leu His Tyr Thr 
1265                1270            

