               SEQUENCE LISTING

<110> BioInvent International AB

<120> MODEL FOR PREDICTION OF TOLERABILITY ISSUES IN CONNECTION WITH INTRAVENOUS ADMINISTRATION OF THERAPEUTIC ANTIBODIES

<130> BIOBX/P76385PC

<160> 203

<170> BiSSAP 1.3.6

<210> 1
<211> 217
<212> PRT
<213> Artificial Sequence


<220> 
<223> Light chain

<400> 1
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Ala Asp Asp His Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser 
                85                  90                  95      
Gln Arg Ala Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 
Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             
Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         

<210> 2
<211> 447
<212> PRT
<213> Artificial Sequence


<220> 
<223> Heavy chain

<400> 2
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Leu Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210> 3
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1A01-VH

<400> 3
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Tyr Met Asn Trp Ile Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Leu Ile Gly Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Tyr Ser Gly Tyr Glu Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 4
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1B07-VH

<400> 4
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Phe Thr Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Asn Ile Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 5
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1C04-VH

<400> 5
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Ser Asp Ser Gly Ala Gly Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Thr His Asp Ser Gly Glu Leu Leu Asp Ala Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         

<210> 6
<211> 124
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1E05-VH

<400> 6
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Asn Tyr Val Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asn Phe Asp Asn Ser Gly Tyr Ala Ile Pro Asp Ala Phe Asp 
            100                 105                 110         
Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 

<210> 7
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> 2A09-VH

<400> 7
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Tyr Ile Ser Arg Asp Ala Asp Ile Thr His Tyr Pro Ala Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Thr Gly Phe Asp Tyr Ala Gly Asp Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 8
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> 2B08-VH

<400> 8
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Leu Ile Gly His Asp Gly Asn Asn Lys Tyr Tyr Leu Asp Ser Leu 
    50                  55                  60                  
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Thr Asp Ser Gly Tyr Asp Leu Leu Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 9
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 2E08-VH

<400> 9
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Gly Phe Ser Asp Asp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Gly Gly Asp Gly Ser Gly Trp Ser Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 10
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5C04-VH

<400> 10
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Trp Arg Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 11
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5C05-VH

<400> 11
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Asn Phe Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 12
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5D07-VH

<400> 12
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ala Tyr Asp Gly Ser Lys Lys Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Tyr Arg Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 13
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5E12-VH

<400> 13
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ile Asn Lys Asp Tyr Ala Asp Ser Met 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Arg Lys Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 14
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5G08-VH

<400> 14
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Arg Trp Asn Gly Met Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 15
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5H06-VH

<400> 15
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asp Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp His Ser Val Ile Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 16
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6A09-VH

<400> 16
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Thr Ser Tyr Asp Gly Asn Thr Lys Tyr Tyr Ala Asn Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Asp Cys Gly Gly Asp Cys Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 17
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6B01-VH

<400> 17
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Gln Leu Gly Glu Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 18
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6C11-VH

<400> 18
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Gly Gly Asp Ile Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 19
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6C12-VH

<400> 19
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Arg Arg Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 20
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6D01-VH

<400> 20
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp His Ser Ala Ala Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 21
<211> 119
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6G03-VH

<400> 21
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Trp Asp Ser Ala Ile Ile Asp Tyr Ala Gly Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Asp Glu Ala Ala Ala Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser 
        115                 

<210> 22
<211> 121
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6G08-VH

<400> 22
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Ser Tyr 
            20                  25                  30          
Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ser Ser Val Gly Ala Tyr Ala Asn Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 23
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6G11-VH

<400> 23
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Leu Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 24
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6H08-VH

<400> 24
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Tyr Lys Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 25
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> 7C07-VH

<400> 25
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Phe Gly Tyr Ile Ile Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210> 26
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> 4B02-VH

<400> 26
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn His 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Thr Trp Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 27
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1A01-VL

<400> 27
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          
Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Asp Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      
Asn Ala Ser Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     

<210> 28
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1B07-VL

<400> 28
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          
Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Asp Asn Gln Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Ala Trp Asp Asp Arg Leu 
                85                  90                  95      
Phe Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     

<210> 29
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1C04-VL

<400> 29
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          
His Val Leu Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      
Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     

<210> 30
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> 1E05-VL

<400> 30
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Asp Asn Asn Ser Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      
Leu Gly Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         



<210> 31
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> 2A09-VL

<400> 31
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          
Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Gly Asn Ser Asp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      
Asn Gly Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         



<210> 32
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> 2B08-VL

<400> 32
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          
Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Thr Trp Asp Asp Ser Leu 
                85                  90                  95      
Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     

<210> 33
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> 2E08-VL

<400> 33
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          
Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      
Arg Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     

<210> 34
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5C04-VL

<400> 34
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Ser Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      
Leu Ser Gly Ser Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         
Gly 
    

<210> 35
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5C05-VL

<400> 35
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Ser Asn Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      
Leu Asn Gly Gln Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         
Gly 
    

<210> 36
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5D07-VL

<400> 36
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Thr Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      
Val Ser Gly Trp Met Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         



<210> 37
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5E12-VL

<400> 37
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser 
                85                  90                  95      
Leu Asn Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         



<210> 38
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5G08-VL

<400> 38
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Ala Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      
Leu Asn Gly Pro Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         
Gly 
    

<210> 39
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> 5H06-VL

<400> 39
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Asn 
                85                  90                  95      
Asn Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 

<210> 40
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6A09-VL

<400> 40
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      
Leu Asn Glu Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         



<210> 41
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6B01-VL

<400> 41
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser 
                85                  90                  95      
Leu Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         



<210> 42
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6C11-VL

<400> 42
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Phe Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Glu Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      
Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         



<210> 43
<211> 110
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6C12-VL

<400> 43
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Ser Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Ser Asp 
                85                  90                  95      
Thr Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 

<210> 44
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6D01-VL

<400> 44
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Gly Asn Ser Ile Arg Pro Ser Gly Gly Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser Leu 
                85                  90                  95      
Ser Ser Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     

<210> 45
<211> 113
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6G03-VL

<400> 45
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Asn Thr Asp Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      
Leu Ser Gly Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         
Gly 
    

<210> 46
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6G08-VL

<400> 46
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Gly Asp Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser 
                85                  90                  95      
Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         



<210> 47
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6G11-VL

<400> 47
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          
Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              
Leu Ile Tyr Ala Asp Asp His Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  
Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Ser 
                85                  90                  95      
Gln Arg Ala Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         



<210> 48
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> 6H08-VL

<400> 48
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Gly Thr Gly Ile 
                85                  90                  95      
Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 

<210> 49
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> 7C07-VL

<400> 49
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          
Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Arg Asp Tyr Glu Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Met Ala Trp Asp Asp Ser Leu 
                85                  90                  95      
Ser Gly Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     

<210> 50
<211> 109
<212> PRT
<213> Artificial Sequence


<220> 
<223> 4B02-VL

<400> 50
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          
Asn Ala Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Ser Thr 
                85                  90                  95      
Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 

<210> 51
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 51
Asp Tyr Tyr Met Asn 
1               5   

<210> 52
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 52
Leu Ile Gly Trp Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 53
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 53
Ala Tyr Ser Gly Tyr Glu Leu Asp Tyr 
1               5                   

<210> 54
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 54
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              

<210> 55
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 55
Asp Asn Asn Asn Arg Pro Ser 
1               5           

<210> 56
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 56
Ala Ala Trp Asp Asp Ser Leu Asn Ala Ser Ile 
1               5                   10      

<210> 57
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 57
Ser Tyr Gly Met His 
1               5   

<210> 58
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 58
Phe Thr Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      
Gly 
    

<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 59
Glu Asn Ile Asp Ala Phe Asp Val 
1               5               

<210> 60
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 60
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              

<210> 61
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 61
Asp Asn Gln Gln Arg Pro Ser 
1               5           

<210> 62
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 62
Trp Asp Asp Arg Leu Phe Gly Pro Val 
1               5                   

<210> 63
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 63
Ser Tyr Ala Met Ser 
1               5   

<210> 64
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 64
Ser Ile Ser Asp Ser Gly Ala Gly Arg Tyr Tyr Ala Asp Ser Val Glu 
1               5                   10                  15      
Gly 
    

<210> 65
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 65
Thr His Asp Ser Gly Glu Leu Leu Asp Ala Phe Asp Ile 
1               5                   10              

<210> 66
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 66
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn His Val Leu 
1               5                   10              

<210> 67
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 67
Gly Asn Ser Asn Arg Pro Ser 
1               5           

<210> 68
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 68
Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      

<210> 69
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 69
Thr Tyr Ala Met Asn 
1               5   

<210> 70
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 70
Val Ile Ser Tyr Asp Gly Ser Asn Lys Asn Tyr Val Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 71
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 71
Asn Phe Asp Asn Ser Gly Tyr Ala Ile Pro Asp Ala Phe Asp Ile 
1               5                   10                  15  

<210> 72
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 72
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 73
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 73
Asp Asn Asn Ser Arg Pro Ser 
1               5           

<210> 74
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 74
Ala Ala Trp Asp Asp Ser Leu Gly Gly Pro Val 
1               5                   10      

<210> 75
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 75
Asn Ala Trp Met Ser 
1               5   

<210> 76
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 76
Tyr Ile Ser Arg Asp Ala Asp Ile Thr His Tyr Pro Ala Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 77
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 77
Gly Phe Asp Tyr Ala Gly Asp Asp Ala Phe Asp Ile 
1               5                   10          

<210> 78
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 78
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Ala Val Asn 
1               5                   10              

<210> 79
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 79
Gly Asn Ser Asp Arg Pro Ser 
1               5           

<210> 80
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 80
Ala Ala Trp Asp Asp Ser Leu Asn Gly Arg Trp Val 
1               5                   10          

<210> 81
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 81
Asp Tyr Tyr Met Ser 
1               5   

<210> 82
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 82
Leu Ile Gly His Asp Gly Asn Asn Lys Tyr Tyr Leu Asp Ser Leu Glu 
1               5                   10                  15      
Gly 
    

<210> 83
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 83
Ala Thr Asp Ser Gly Tyr Asp Leu Leu Tyr 
1               5                   10  

<210> 84
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 84
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              

<210> 85
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 85
Tyr Asp Asp Leu Leu Pro Ser 
1               5           

<210> 86
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 86
Thr Thr Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      

<210> 87
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 87
Asp Tyr Tyr Met Ser 
1               5   

<210> 88
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 88
Ala Ile Gly Phe Ser Asp Asp Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 89
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 89
Gly Asp Gly Ser Gly Trp Ser Phe 
1               5               

<210> 90
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 90
Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn 
1               5                   10              

<210> 91
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 91
Asp Asn Asn Lys Arg Pro Ser 
1               5           

<210> 92
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 92
Ala Thr Trp Asp Asp Ser Leu Arg Gly Trp Val 
1               5                   10      

<210> 93
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 93
Asn Tyr Gly Met His 
1               5   

<210> 94
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 94
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 95
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 95
Trp Arg Asp Ala Phe Asp Ile 
1               5           

<210> 96
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 96
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 97
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 97
Ser Asp Asn Gln Arg Pro Ser 
1               5           

<210> 98
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 98
Ala Ala Trp Asp Asp Ser Leu Ser Gly Ser Trp Val 
1               5                   10          

<210> 99
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 99
Thr Tyr Gly Met His 
1               5   

<210> 100
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 100
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 101
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 101
Glu Asn Phe Asp Ala Phe Asp Val 
1               5               

<210> 102
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 102
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 103
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 103
Ser Asn Ser Gln Arg Pro Ser 
1               5           

<210> 104
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 104
Ala Ala Trp Asp Asp Ser Leu Asn Gly Gln Val Val 
1               5                   10          

<210> 105
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 105
Thr Tyr Gly Met His 
1               5   

<210> 106
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 106
Val Ile Ala Tyr Asp Gly Ser Lys Lys Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 107
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 107
Glu Tyr Arg Asp Ala Phe Asp Ile 
1               5               

<210> 108
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 108
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 109
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 109
Gly Asn Ser Asn Arg Pro Ser 
1               5           

<210> 110
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 110
Ala Ala Trp Asp Asp Ser Val Ser Gly Trp Met 
1               5                   10      

<210> 111
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 111
Ser Tyr Gly Met His 
1               5   

<210> 112
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 112
Val Ile Ser Tyr Asp Gly Ile Asn Lys Asp Tyr Ala Asp Ser Met Lys 
1               5                   10                  15      
Gly 
    

<210> 113
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 113
Glu Arg Lys Asp Ala Phe Asp Ile 
1               5               

<210> 114
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 114
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 115
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 115
Ser Asn Asn Gln Arg Pro Ser 
1               5           

<210> 116
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 116
Ala Thr Trp Asp Asp Ser Leu Asn Gly Leu Val 
1               5                   10      

<210> 117
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 117
Asn Tyr Gly Met His 
1               5   

<210> 118
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 118
Val Ile Ser Tyr Asp Gly Ser Asn Arg Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 119
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 119
Asp Arg Trp Asn Gly Met Asp Val 
1               5               

<210> 120
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 120
Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 121
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 121
Ala Asn Asn Gln Arg Pro Ser 
1               5           

<210> 122
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 122
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Trp Val 
1               5                   10          

<210> 123
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 123
Ser Tyr Gly Met His 
1               5   

<210> 124
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 124
Val Ile Ser Tyr Asp Gly Ser Asp Thr Ala Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 125
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 125
Asp His Ser Val Ile Gly Ala Phe Asp Ile 
1               5                   10  

<210> 126
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 126
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              

<210> 127
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 127
Asp Asn Asn Lys Arg Pro Ser 
1               5           

<210> 128
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 128
Ser Ser Tyr Ala Gly Ser Asn Asn Val Val 
1               5                   10  

<210> 129
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 129
Ser Tyr Gly Met His 
1               5   

<210> 130
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 130
Val Thr Ser Tyr Asp Gly Asn Thr Lys Tyr Tyr Ala Asn Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 131
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 131
Glu Asp Cys Gly Gly Asp Cys Phe Asp Tyr 
1               5                   10  

<210> 132
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 132
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 133
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 133
Gly Asn Ser Asn Arg Pro Ser 
1               5           

<210> 134
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 134
Ala Ala Trp Asp Asp Ser Leu Asn Glu Gly Val 
1               5                   10      

<210> 135
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 135
Asn Tyr Gly Met His 
1               5   

<210> 136
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 136
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 137
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 137
Asp Gln Leu Gly Glu Ala Phe Asp Ile 
1               5                   

<210> 138
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 138
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 139
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 139
Asp Asn Asn Lys Arg Pro Ser 
1               5           

<210> 140
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 140
Ala Thr Trp Asp Asp Ser Leu Ser Gly Pro Val 
1               5                   10      

<210> 141
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 141
Asp Tyr Gly Met Ser 
1               5   

<210> 142
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 142
Ala Ile Ser Gly Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 143
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 143
Gly Asp Ile Asp Tyr Phe Asp Tyr 
1               5               

<210> 144
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 144
Thr Gly Ser Ser Ser Asn Phe Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 145
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 145
Glu Asn Asn Lys Arg Pro Ser 
1               5           

<210> 146
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 146
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      

<210> 147
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 147
Ser Tyr Gly Met His 
1               5   

<210> 148
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 148
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 149
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 149
Glu Arg Arg Asp Ala Phe Asp Ile 
1               5               

<210> 150
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 150
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 151
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 151
Ser Asp Asn Gln Arg Pro Ser 
1               5           

<210> 152
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 152
Ala Thr Trp Asp Ser Asp Thr Pro Val 
1               5                   

<210> 153
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 153
Ser Tyr Gly Met His 
1               5   

<210> 154
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 154
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 155
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 155
Asp His Ser Ala Ala Gly Tyr Phe Asp Tyr 
1               5                   10  

<210> 156
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 156
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              

<210> 157
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 157
Gly Asn Ser Ile Arg Pro Ser 
1               5           

<210> 158
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 158
Ala Ser Trp Asp Asp Ser Leu Ser Ser Pro Val 
1               5                   10      

<210> 159
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 159
Ser Tyr Gly Met His 
1               5   

<210> 160
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 160
Gly Ile Ser Trp Asp Ser Ala Ile Ile Asp Tyr Ala Gly Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 161
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 161
Asp Glu Ala Ala Ala Gly Ala Phe Asp Ile 
1               5                   10  

<210> 162
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 162
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 163
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 163
Gly Asn Thr Asp Arg Pro Ser 
1               5           

<210> 164
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 164
Ala Ala Trp Asp Asp Ser Leu Ser Gly Pro Val Val 
1               5                   10          

<210> 165
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 165
Ser Tyr Gly Ile Ser 
1               5   

<210> 166
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 166
Gly Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 167
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 167
Ser Val Gly Ala Tyr Ala Asn Asp Ala Phe Asp Ile 
1               5                   10          

<210> 168
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 168
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 169
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 169
Gly Asp Thr Asn Arg Pro Ser 
1               5           

<210> 170
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 170
Ala Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      

<210> 171
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 171
Ser Tyr Gly Met His 
1               5   

<210> 172
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 172
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 173
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 173
Glu Leu Tyr Asp Ala Phe Asp Ile 
1               5               

<210> 174
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 174
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 175
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 175
Ala Asp Asp His Arg Pro Ser 
1               5           

<210> 176
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 176
Ala Ser Trp Asp Asp Ser Gln Arg Ala Val Ile 
1               5                   10      

<210> 177
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 177
Asn Tyr Gly Met His 
1               5   

<210> 178
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 178
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 179
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 179
Glu Tyr Lys Asp Ala Phe Asp Ile 
1               5               

<210> 180
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 180
Thr Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              

<210> 181
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 181
Asp Asn Asn Lys Arg Pro Ser 
1               5           

<210> 182
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 182
Gln Ala Trp Gly Thr Gly Ile Arg Val 
1               5                   

<210> 183
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 183
Ser Tyr Gly Met His 
1               5   

<210> 184
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 184
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 185
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 185
Glu Phe Gly Tyr Ile Ile Leu Asp Tyr 
1               5                   

<210> 186
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 186
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              

<210> 187
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 187
Arg Asp Tyr Glu Arg Pro Ser 
1               5           

<210> 188
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 188
Met Ala Trp Asp Asp Ser Leu Ser Gly Val Val 
1               5                   10      

<210> 189
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 189
Asn His Gly Met His 
1               5   

<210> 190
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 190
Val Ile Ser Tyr Asp Gly Thr Asn Lys Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      
Gly 
    

<210> 191
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 191
Glu Thr Trp Asp Ala Phe Asp Val 
1               5               

<210> 192
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 192
Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Asn Ala Asn 
1               5                   10              

<210> 193
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 193
Asp Asn Asn Lys Arg Pro Ser 
1               5           

<210> 194
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 194
Gln Ala Trp Asp Ser Ser Thr Val Val 
1               5                   

<210> 195
<211> 447
<212> PRT
<213> Artificial Sequence


<220> 
<223> BI-1206 N297Q

<400> 195
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Leu Tyr Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210> 196
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH1

<400> 196
Ser Tyr Gly Met His 
1               5   

<210> 197
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH2

<400> 197
Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 198
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRH3

<400> 198
Glu Leu Tyr Asp Ala Phe Asp Ile 
1               5               

<210> 199
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL1

<400> 199
Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His 
1               5                   10                  

<210> 200
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL2

<400> 200
Ala Asp Asp His Arg Pro Ser 
1               5           

<210> 201
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDRL3

<400> 201
Ala Ser Trp Asp Asp Ser Gln Arg Ala Val Ile 
1               5                   10      

<210> 202
<211> 330
<212> PRT
<213> Homo sapiens


<220> 
<223> IgG1-CH

<400> 202
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 

<210> 203
<211> 105
<212> PRT
<213> Homo sapiens


<220> 
<223> λ-CL

<400> 203
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      
Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          
Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              
Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  
Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  
His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      
Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 

