                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITIONS TO TREAT OCULAR DISEASES

<130>  ROZET 20084

<160>  50    

<170>  PatentIn version 3.3

<210>  1
<211>  2924
<212>  DNA
<213>  Homo sapiens

<400>  1
aaacactcca gccgctgaga gccccctttg gcacttggca gcacgcggcg gcgggctcct     60

cggctcaact tcgaggagtc tccgcgacgc aacttttggg gacgctttgc atttaagaga    120

gaacgaccga ggaggaggag cgctctgccc ggccgccgct acctgcgggg agctcaccag    180

caaacgccac tgcagacgaa ggacccaaag aacgtaaagg gcaaactgcc gccgcgggga    240

gggggcaccg ccgagaagtt agagtgtccc agagacaacc tgctcgagcg ctcggccgga    300

gacactaagg cggcccgggg cgcggcgtgg ccctgggctg gtcccccagc cccctcctcc    360

ggggcgggag cgacgccggg gcgcgacgag ccccggccgg ccgagcgggt ctccgcgggc    420

agccaacatt gatttcctcc gggccgaggg cgagggcccg ggaggcggcg ggctgcagcc    480

gcggcagggc gagagcatgt ccaagccggt ggaccacgtc aagcggccca tgaacgcctt    540

catggtgtgg tcgcgggctc agcggcgcaa gatggcccag gagaacccca agatgcacaa    600

ctcggagatc agcaagcgct tgggcgccga gtggaaactg ctcacagagt cggagaagcg    660

gccgttcatc gacgaggcca agcgtctacg cgccatgcac atgaaggagc accccgacta    720

caagtaccgg ccgcggcgca agcccaagac gctgctcaag aaggacaagt tcgccttccc    780

ggtgccctac ggcctgggcg gcgtggcgga cgccgagcac cctgcgctca aggcgggcgc    840

cgggctgcac gcgggggcgg gcggcggcct ggtgcctgag tcgctgctcg ccaatcccga    900

gaaggcggcc gcggccgccg ccgctgccgc cgcacgcgtc ttcttcccgc agtcggccgc    960

tgccgccgcc gctgccgccg ccgccgccgc cgcgggcagc ccctactcgc tgctcgacct   1020

gggctccaaa atggcagaga tctcgtcgtc ctcgtccggc ctcccgtacg cgtcgtcgct   1080

gggctacccg accgcgggcg cgggcgcctt ccacggcgcg gcggcggcgg ctgcagcggc   1140

ggccgccgcc gccggggggc acacgcactc gcaccccagc ccgggcaacc cgggctacat   1200

gatcccgtgc aactgcagcg cgtggcccag ccccgggctg cagccgccgc tcgcctacat   1260

cctgctgccg ggcatgggca agccccagct ggacccctac cccgcggcct acgctgccgc   1320

gctatgaccc cgcggggccg cctcgcgagg accggtgtgc acacgtgtac atatgtatag   1380

gtacgagcgc tgcggcctcc ccgtgcgccc tcccgcgacc gggggcccgg tttgtatgta   1440

catagaatgt ataggtgcca ggtagaggca gagaggccag gcggggcagg agtggccaag   1500

cgcgcaaggg cgcgggcgag caggcctgtg aattcgcagg atcatttcag acccgcactt   1560

cggcagccaa ctcgaaagca ggcggttgtg tgcggcagca gttggcgttt gctttgcact   1620

tcggaacctg ttgcgttttg acccacggag gtggaggagt aactttttga catgttggcc   1680

tttccagttt tgttggaagt ttcatggtcg gttttgtttt tgtttctcat tcttcttcct   1740

cgcccctcag ccccccaacc cccaaccccc tcccggtccg tgttgcatgc acgctgttca   1800

aatgtgaggt ctgaaatggc tggcacacgg gaaaagctgc ttgtgtcatt cgtttctggg   1860

agtgggatgg ctctgagcag cctcgcctcc ctgtttgtac tatttgaact ttgcagatct   1920

ctgttctctc aagcagaact cccaaccaga tccattcttg accagtgacc ggctcgaatc   1980

tggccttttg tgtgagatga tcacggtttc ttttgtttat cacgccattt gcaaatcaga   2040

gcaagagctc tttctcaagg gcaagaaacg caaacaagaa atatttgtga gatgaaagtt   2100

gtcaattgga ttttcttcct aaacaaacaa caacaacaaa ctactagaag tctccctgag   2160

tccactcgct tggatttctg acacagttta caaaaaagga aaaaggcact gctcctattt   2220

tcccttatgg ctgagttcac cttaagattg taaatgtgta tatgtcagtg aaaacattga   2280

ggcttggaaa atgtgttatt ttcgttgccc taagtttgag tcgactttag actcaaaaac   2340

attttgagcg aatatcaaag ttaactttta aaaattgcga aactatttca gaatcgcaat   2400

tttatcgaag attaaatcag acttttttgt ctggtaatta tatatttatt atttagcaaa   2460

actgaagaaa aaaagcacag aattgtttca acagatgtct ctcattttca gctagcattt   2520

ctctcccaag ttgagctggt ttaatgtgtt ttggatttcc ctcctcaatt ggcttatttt   2580

ttagatcacc tgcaattcat ttgcaaattg caataaaaca cattttagaa aaaaggaacc   2640

ttcaattatt agctttgttt ctttttaaat gtatatattt tgactaatgt ttgtgaatga   2700

agttggctaa catgtattta gtttcatttt ggctttatgt aatataaagt ttttaaaatt   2760

ttaaatatgg ttttaacctt tatgtgtaaa tgattttcta gtgtgacctt ctaatttaat   2820

attagacgtc taaggtatat ctgtaaatta gaatccgact atcactctgt tcattttttt   2880

tgaacaaaga gtttaaataa agcctgaacc agggaaaaga aaaa                    2924


<210>  2
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Lys Pro Val Asp His Val Lys Arg Pro Met Asn Ala Phe Met 
1               5                   10                  15      


Val Trp Ser Arg Ala Gln Arg Arg Lys Met Ala Gln Glu Asn Pro Lys 
            20                  25                  30          


Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys Leu 
        35                  40                  45              


Leu Thr Glu Ser Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg Leu 
    50                  55                  60                  


Arg Ala Met His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro Arg 
65                  70                  75                  80  


Arg Lys Pro Lys Thr Leu Leu Lys Lys Asp Lys Phe Ala Phe Pro Val 
                85                  90                  95      


Pro Tyr Gly Leu Gly Gly Val Ala Asp Ala Glu His Pro Ala Leu Lys 
            100                 105                 110         


Ala Gly Ala Gly Leu His Ala Gly Ala Gly Gly Gly Leu Val Pro Glu 
        115                 120                 125             


Ser Leu Leu Ala Asn Pro Glu Lys Ala Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ala Arg Val Phe Phe Pro Gln Ser Ala Ala Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Ala Ala Ala Ala Gly Ser Pro Tyr Ser Leu Leu Asp Leu Gly 
                165                 170                 175     


Ser Lys Met Ala Glu Ile Ser Ser Ser Ser Ser Gly Leu Pro Tyr Ala 
            180                 185                 190         


Ser Ser Leu Gly Tyr Pro Thr Ala Gly Ala Gly Ala Phe His Gly Ala 
        195                 200                 205             


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly His Thr His 
    210                 215                 220                 


Ser His Pro Ser Pro Gly Asn Pro Gly Tyr Met Ile Pro Cys Asn Cys 
225                 230                 235                 240 


Ser Ala Trp Pro Ser Pro Gly Leu Gln Pro Pro Leu Ala Tyr Ile Leu 
                245                 250                 255     


Leu Pro Gly Met Gly Lys Pro Gln Leu Asp Pro Tyr Pro Ala Ala Tyr 
            260                 265                 270         


Ala Ala Ala Leu 
        275     


<210>  3
<211>  17
<212>  DNA
<213>  Mus musculus

<400>  3
aattcattgt tctctgg                                                    17


<210>  4
<211>  16
<212>  DNA
<213>  Mus musculus

<400>  4
tgttattaaa tttaaa                                                     16


<210>  5
<211>  16
<212>  DNA
<213>  Mus musculus

<400>  5
taaatttaaa ataagt                                                     16


<210>  6
<211>  16
<212>  DNA
<213>  Mus musculus

<400>  6
tttaaattta ataaca                                                     16


<210>  7
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  7
aacaatgata gtttt                                                      15


<210>  8
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  8
tttcatttta aaaaat                                                     16


<210>  9
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  9
gctgttttgt ttctttt                                                    17


<210>  10
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  10
gggcatttgt ttatctc                                                    17


<210>  11
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  11
tgtcatttgt ttggaat                                                    17


<210>  12
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  12
tttaataata tgttag                                                     16


<210>  13
<211>  17
<212>  DNA
<213>  Mus musculus

<400>  13
ccagagaaca atgaatt                                                    17


<210>  14
<211>  16
<212>  DNA
<213>  Mus musculus

<400>  14
tttaaattta ataaca                                                     16


<210>  15
<211>  16
<212>  DNA
<213>  Mus musculus

<400>  15
acttatttta aattta                                                     16


<210>  16
<211>  16
<212>  DNA
<213>  Mus musculus

<400>  16
tgttattaaa tttaaa                                                     16


<210>  17
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  17
aaaactatca ttgtt                                                      15


<210>  18
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  18
attttttaaa atgaaa                                                     16


<210>  19
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  19
aaaagaaaca aaacagc                                                    17


<210>  20
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  20
gagataaaca aatgccc                                                    17


<210>  21
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  21
attccaaaca aatgaca                                                    17


<210>  22
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  22
ctaacatatt attaaa                                                     16


<210>  23
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  c MCOR-guide RNA

<400>  23
ctcacagttt ggtccaggct ggg                                             23


<210>  24
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>   CTCF1+Ps_guide RNA

<400>  24
tcttcagacg ccgcgcttta                                                 20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>   CTCF2-guide RNA

<400>  25
gtgttttatg gacgggctcg                                                 20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>   CTCF3_guide RNA

<400>  26
tccatagtaa tgatcgcatc                                                 20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>   Enh1-guide RNA

<400>  27
aacacaggga ggtcgctttc                                                 20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Enh2-guide RNA

<400>  28
tgggacacaa gcaccggcct                                                 20


<210>  29
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  c MCOR_guide RNA 3'

<400>  29
attccccagc agagaggcgc tgg                                             23


<210>  30
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>   CTCF1+Ps_guide RNA3'

<400>  30
gcccgctccg tttgctcgcc                                                 20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>   CTCF2-guide RNA 3'

<400>  31
ctcggcataa agtttgtaat                                                 20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>   CTCF3-guide RNA 3'

<400>  32
ctcggcataa agtttgtaat                                                 20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Enh1_guide RNA 3'

<400>  33
caaaaatcct tgggctaact                                                 20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Enh2-guide RNA 3'

<400>  34
gttccagtag ggcaacgcaa                                                 20


<210>  35
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer 1

<400>  35
tgctcccctg ttatgttcag atc                                             23


<210>  36
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer 2

<400>  36
gtgcaaacca attcatgtta                                                 20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  SOX21 primer 1

<400>  37
gatgcacaac tcggagatca                                                 20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  SOX21 primer 2

<400>  38
ggcgaacttg tcctttttga                                                 20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  DCT primer 1

<400>  39
aattcttcaa ccggacatgc                                                 20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  DCT primer 2

<400>  40
ttgcgtggtg atcacgtagt                                                 20


<210>  41
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  GusB primer 1

<400>  41
ctgcggttgt gatgtggtct gt                                              22


<210>  42
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  GusB primer 2

<400>  42
tgtgggtgat cagcgtctta aagt                                            24


<210>  43
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Hprt1 primer 1

<400>  43
gttggataca ggccagactt tgtt                                            24


<210>  44
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Hprt1 primer 2

<400>  44
aaacgtgatt caaatccctg aagta                                           25


<210>  45
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Alb primer 1

<400>  45
gggacagtga gtacccagac atcta                                           25


<210>  46
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Alb primer 2

<400>  46
ccagacttgg tgttggatgc tt                                              22


<210>  47
<211>  252
<212>  DNA
<213>  Mus musculus

<400>  47
gatgtctttt aaacaaaagc tgcaagagaa tcttttggtc taaacctgac ctagaacctg     60

acctagaacc tgacctagag cctgacctag agcctgacct agagcctgac ctagaacctg    120

acctagaacc tgacctagag cctgacctag agcctgacct agagcctgac ctagaaccct    180

atcatgttat taaatttaaa ataagtgccc agagaacaat gaatttataa atactatctc    240

tgggttaaat ac                                                        252


<210>  48
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  Human synthenic sequence: sequences correspond to the murine and 
       human

<400>  48
taggttcagg agtaaggtga gcagccgagc aagagactgc atggaagagc tctggaaata     60

gccccttccg ctatcttgat gtagcatttc cggtactgat gggctcccgg agagaggatt    120

tggatttgcc agatgtgctt gctctattta ggcagcgctt ctgctcaagg gtggattcca    180

ttttgcagat tctgcacagc ttgatgaaat gtggctctgc ccgagataaa caaatgccca    240

ttgtcatttt gaaggcatat gtgtgctttc attttaaaaa atatccttta aacaatgata    300

gtttttaacc tgggaattca acgttctcca ggtattttat tttagattta ataatatgtt    360

aggggattct ttgatgggtt tgtttagact gaaaagtttg cttctgtcat ttgtttggaa    420

taaatttgca tcatgctaca accacaagct gcttttgatg gttggctgtt ttgtttcttt    480

tctaagcgct gatatccaga agtgggtgtt taagtgcccc acactctcac cactacctta    540

cttcctgaat tggcttggtg gtcttgactc tgaatgaaac tgccccttgg cctcttccct    600

accatctcta aattgccttc ttttccttca ttgtgatgga atgtctgcat ggatggatgg    660

tcgagtgctc acatatcatg tcccatttga tactctactg agtttgtggg agacagcacc    720

cccttt                                                               726


<210>  49
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR-Cas9 guide primer 1

<400>  49
gaggatatac taacaaagag                                                 20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CRISPR-Cas9 guide primer 2

<400>  50
gggagctggg caggtaagaa                                                 20


