                         SEQUENCE LISTING

<110>  NANJING LEGEND BIOTECH
       Tu, Zhongyuan
       Zhang, Yafeng
       Wu, Shu
 
<120>  Activation induced cytokine production in immune cells

<130>  55570-99001

<150>  PCT/CN2020/094741
<151>  2020-06-05

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(486)
<223>  anti-CD19 CAR

<220>
<221>  MISC_FEATURE
<222>  (487)..(508)
<223>  P2A

<220>
<221>  MISC_FEATURE
<222>  (509)..(670)
<223>  IL-15

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile Ser 
            500                 505                 510         


Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu 
        515                 520                 525             


Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu 
    530                 535                 540                 


Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn 
545                 550                 555                 560 


Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His 
                565                 570                 575     


Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys 
            580                 585                 590         


Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu 
        595                 600                 605             


Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile 
    610                 615                 620                 


Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly 
625                 630                 635                 640 


Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu 
                645                 650                 655     


Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            660                 665                 670 


<210>  2
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(486)
<223>  anti-CD19 CAR

<220>
<221>  MISC_FEATURE
<222>  (487)..(508)
<223>  P2A

<220>
<221>  MISC_FEATURE
<222>  (509)..(685)
<223>  IL-7

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
                485                 490                 495     


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Phe His Val 
            500                 505                 510         


Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile Leu Val Leu Leu 
        515                 520                 525             


Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys Asp Ser Lys Gln 
    530                 535                 540                 


Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met 
545                 550                 555                 560 


Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys 
                565                 570                 575     


Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala 
            580                 585                 590         


Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe 
        595                 600                 605             


Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn 
    610                 615                 620                 


Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala 
625                 630                 635                 640 


Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys 
                645                 650                 655     


Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys 
            660                 665                 670         


Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
        675                 680                 685 


<210>  3
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(487)
<223>  anti-BCMA CAR

<220>
<221>  MISC_FEATURE
<222>  (488)..(509)
<223>  P2A

<220>
<221>  MISC_FEATURE
<222>  (510)..(671)
<223>  IL-15

<400>  3

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg 
        35                  40                  45              


Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn 
                165                 170                 175     


Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser 
            180                 185                 190         


Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys 
225                 230                 235                 240 


Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Arg Ile 
            500                 505                 510         


Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu 
        515                 520                 525             


Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile 
    530                 535                 540                 


Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val 
545                 550                 555                 560 


Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met 
                565                 570                 575     


His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys 
            580                 585                 590         


Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser 
        595                 600                 605             


Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile 
    610                 615                 620                 


Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser 
625                 630                 635                 640 


Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe 
                645                 650                 655     


Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
            660                 665                 670     


<210>  4
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(487)
<223>  anti-BCMA CAR

<220>
<221>  MISC_FEATURE
<222>  (488)..(509)
<223>  P2A

<220>
<221>  MISC_FEATURE
<222>  (510)..(686)
<223>  IL-7

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg 
        35                  40                  45              


Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn 
                165                 170                 175     


Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser 
            180                 185                 190         


Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys 
225                 230                 235                 240 


Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                485                 490                 495     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Phe His 
            500                 505                 510         


Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile Leu Val Leu 
        515                 520                 525             


Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys Asp Ser Lys 
    530                 535                 540                 


Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser 
545                 550                 555                 560 


Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe 
                565                 570                 575     


Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg 
            580                 585                 590         


Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp 
        595                 600                 605             


Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu 
    610                 615                 620                 


Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu 
625                 630                 635                 640 


Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln 
                645                 650                 655     


Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile 
            660                 665                 670         


Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
        675                 680                 685     


<210>  5
<211>  2236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1458)
<223>  anti-CD19 CAR coding sequence

<220>
<221>  misc_feature
<222>  (1516)..(2001)
<223>  complement of IL-15 coding sequence

<220>
<221>  misc_feature
<222>  (2194)..(2235)
<223>  3NF-kB

<400>  5
atggcactgc ctgtgaccgc actgctgctg ccactggcac tgctgctgca cgcagcaagg       60

ccagacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gcagggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagca ggctgcactc cggagtgcct      240

tctcggttca gcggatccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggaagcg gcggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggac tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg actggagtgg ctgggcgtga tctggggcag cgagaccaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctagg ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgagacc cgaggcctgt aggcctgcag caggaggagc agtgcacacc      900

aggggactgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtgga      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggcaggaa gaagctgctg     1020

tacatcttca agcagccttt tatgagacca gtgcagacaa cccaggagga ggacggctgc     1080

agctgtaggt tcccagaaga ggaggaggga ggatgtgagc tgagggtgaa gttttctcgg     1140

agcgcagatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggccggagag aggagtacga cgtgctggat aagaggcgcg gcagagatcc tgagatgggc     1260

ggcaagccac ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagaga ggaggagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc cctgcacatg     1440

caggccctgc ctccaaggta actcacacaa aaaaccaaca cacagatgta atgaaaataa     1500

agatatttta ttttaggatg tattgatgaa catctgcacg atgtgcacaa agctctgcag     1560

gaactccttg atgttcttct cctccagctc ctcacactcc ttgcagccgc tctctgtcac     1620

attgccgttg gagctcagag aattgttggc caggatgatc agattctcca cggtatcgtg     1680

gatagaggcg tcgccagact ccagggagat gacctgcagc tccagcagaa aacacttcat     1740

ggcggtcacc ttgcaggaag ggtgcacatc gctctctgta tacagggtgg cgtcgatgtg     1800

catagactgg atcagatcct cgatcttctt caggtcggag atcacattca cccagttggc     1860

ctctgtcttg ggcaggccgg cgctaaagca gcccaggatg aacacgtgga tgccggcctc     1920

ggtcaggaag tgagagttca gcagcagaca caggtagcac tggatgctga tagatctcag     1980

gtggggcttg gagatccgca tggctctgtc tcaggtcagt atagaagctt tgatgtgaag     2040

tcagccaaga acagctgaac actacttctg ctgaggccct tttataggag ggattgcttc     2100

ctgtgaataa taggaggata ttgtccacat ccagtaaaga ggaaatcccc aactgcatcc     2160

aaaaagtttt ctgggaatat ccactgctgc aggagtggaa agtccccagt ggaaagtccc     2220

cagtggaaag tcccca                                                     2236


<210>  6
<211>  2281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1458)
<223>  anti-CD19 CAR coding sequence

<220>
<221>  misc_feature
<222>  (1516)..(2046)
<223>  complement of IL-7 coding sequence

<220>
<221>  misc_feature
<222>  (2239)..(2280)
<223>  3NF-kB

<400>  6
atggcactgc ctgtgaccgc actgctgctg ccactggcac tgctgctgca cgcagcaagg       60

ccagacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gcagggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagca ggctgcactc cggagtgcct      240

tctcggttca gcggatccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggaagcg gcggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggac tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg actggagtgg ctgggcgtga tctggggcag cgagaccaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctagg ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgagacc cgaggcctgt aggcctgcag caggaggagc agtgcacacc      900

aggggactgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtgga      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggcaggaa gaagctgctg     1020

tacatcttca agcagccttt tatgagacca gtgcagacaa cccaggagga ggacggctgc     1080

agctgtaggt tcccagaaga ggaggaggga ggatgtgagc tgagggtgaa gttttctcgg     1140

agcgcagatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggccggagag aggagtacga cgtgctggat aagaggcgcg gcagagatcc tgagatgggc     1260

ggcaagccac ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagaga ggaggagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc cctgcacatg     1440

caggccctgc ctccaaggta actcacacaa aaaaccaaca cacagatgta atgaaaataa     1500

agatatttta ttttagtgct cctttgtgcc catcaggatc ttattccaac aggtcttgat     1560

ctcctgcagc agccgcttca ggaagcacag gtcattcagc ttcttctgct ccttcagaga     1620

cttgttctcc tccagggact ttgtgggctg ggcctctccc agtgctgctg gcttccttcc     1680

cttcacctgg ccggtacagt tcagcaggat tgtggtgccc tcggacacct tcagcaggtg     1740

cagatcgaag tcgccggtgc tattcatctt cagaaactgc ctcagctttc tggcggcccg     1800

aaacaggaac atgccctcct tgttggcatc acagatgtgc cgcttaaaga aattaaactc     1860

attgttcagg cagttgctgc cgatctcctt catagaatcc agcagctggt cgatggacac     1920

catcagcacg ctctcatact gcttagagtc cttgccctcg atatcgcagt cggagcttgc     1980

cactggcagc agcaccagga tcagaggggg caggccgaag atgtacctaa aagacacgtg     2040

gaacatggct ctgtctcagg tcagtataga agctttgatg tgaagtcagc caagaacagc     2100

tgaacactac ttctgctgag gcccttttat aggagggatt gcttcctgtg aataatagga     2160

ggatattgtc cacatccagt aaagaggaaa tccccaactg catccaaaaa gttttctggg     2220

aatatccact gctgcaggag tggaaagtcc ccagtggaaa gtccccagtg gaaagtcccc     2280

a                                                                     2281


<210>  7
<211>  2239
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1461)
<223>  anti-BCMA CAR coding sequence

<220>
<221>  misc_feature
<222>  (1519)..(2004)
<223>  complement of IL-15 coding sequence

<220>
<221>  misc_feature
<222>  (2197)..(2238)
<223>  3NF-kB

<400>  7
atggcactgc cagtgacagc actgctgctg cctctggcac tgctgctgca cgcagcaagg       60

cctgccgtgc agctggtgga gtccggcggc ggcctggtgc aggccggcga ctctctgaga      120

ctgacatgca ccgcctccgg cagggccttc tctacatact ttatggcctg gttcagacag      180

gccccaggca aggagaggga gtttgtggca ggaatcgcat ggtctggagg aagcaccgca      240

tacgcagact ctgtgaaggg ccgcttcaca atcagccggg ataacgccaa gaataccgtg      300

tatctgcaga tgaactccct gaagtctgag gataccgccg tgtactattg cgcctccaga      360

ggcatcgagg tggaggagtt tggagcatgg ggacagggaa cacaggtgac cgtgagctcc      420

ggaggaggag gatctcaggt gcagctggag gagtccggag gaggatctgt gcaggcagga      480

ggcagcctga ggctgtcctg tgcctacaca tatagcacct actccaacta ctatatggga      540

tggtttaggg aggcaccagg caaggcccgg acatctgtgg ccatcatctc tagcgacacc      600

acaatcacct acaaggatgc cgtgaagggc agattcacaa tcagcaagga caacgccaag      660

aataccctgt atctgcagat gaatagcctg aagcctgagg actccgccat gtacaggtgc      720

gccgcctgga catctgattg gagcgtggcc tattggggcc agggcacaca ggtgaccgtg      780

tcctctacca gcaccacaac ccctgcacca aggccaccta caccagcacc taccatcgcc      840

tctcagcctc tgagcctgag accagaggcc tgtaggccag cagcaggagg agcagtgcac      900

acccggggcc tggacttcgc ctgcgatatc tacatctggg caccactggc aggaacatgt      960

ggagtgctgc tgctgagcct ggtcatcacc ctgtactgca agagaggcag gaagaagctg     1020

ctgtatatct ttaagcagcc attcatgcgc cccgtgcaga caacccagga ggaggacggc     1080

tgctcctgtc ggtttccaga agaggaggag ggaggatgtg agctgagggt gaagttcagc     1140

aggtccgcag atgcaccagc ataccagcag ggccagaatc agctgtataa cgagctgaat     1200

ctgggccgga gagaggagta tgacgtgctg gataagagga ggggaaggga tccagagatg     1260

ggaggcaagc ctcggagaaa gaacccacag gagggcctgt acaatgagct gcagaaggac     1320

aagatggccg aggcctatag cgagatcggc atgaagggag agaggaggag gggcaaggga     1380

cacgatggcc tgtaccaggg cctgtccaca gccaccaagg acacctatga tgccctgcac     1440

atgcaggccc tgccaccccg gtaactcaca caaaaaacca acacacagat gtaatgaaaa     1500

taaagatatt ttattttagg atgtattgat gaacatctgc acgatgtgca caaagctctg     1560

caggaactcc ttgatgttct tctcctccag ctcctcacac tccttgcagc cgctctctgt     1620

cacattgccg ttggagctca gagaattgtt ggccaggatg atcagattct ccacggtatc     1680

gtggatagag gcgtcgccag actccaggga gatgacctgc agctccagca gaaaacactt     1740

catggcggtc accttgcagg aagggtgcac atcgctctct gtatacaggg tggcgtcgat     1800

gtgcatagac tggatcagat cctcgatctt cttcaggtcg gagatcacat tcacccagtt     1860

ggcctctgtc ttgggcaggc cggcgctaaa gcagcccagg atgaacacgt ggatgccggc     1920

ctcggtcagg aagtgagagt tcagcagcag acacaggtag cactggatgc tgatagatct     1980

caggtggggc ttggagatcc gcatggctct gtctcaggtc agtatagaag ctttgatgtg     2040

aagtcagcca agaacagctg aacactactt ctgctgaggc ccttttatag gagggattgc     2100

ttcctgtgaa taataggagg atattgtcca catccagtaa agaggaaatc cccaactgca     2160

tccaaaaagt tttctgggaa tatccactgc tgcaggagtg gaaagtcccc agtggaaagt     2220

ccccagtgga aagtcccca                                                  2239


<210>  8
<211>  2284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1461)
<223>  anti-BCMA CAR coding sequence

<220>
<221>  misc_feature
<222>  (1519)..(2049)
<223>  complement of IL-7 coding sequence

<220>
<221>  misc_feature
<222>  (2242)..(2283)
<223>  3NF-kB

<400>  8
atggcactgc cagtgacagc actgctgctg cctctggcac tgctgctgca cgcagcaagg       60

cctgccgtgc agctggtgga gtccggcggc ggcctggtgc aggccggcga ctctctgaga      120

ctgacatgca ccgcctccgg cagggccttc tctacatact ttatggcctg gttcagacag      180

gccccaggca aggagaggga gtttgtggca ggaatcgcat ggtctggagg aagcaccgca      240

tacgcagact ctgtgaaggg ccgcttcaca atcagccggg ataacgccaa gaataccgtg      300

tatctgcaga tgaactccct gaagtctgag gataccgccg tgtactattg cgcctccaga      360

ggcatcgagg tggaggagtt tggagcatgg ggacagggaa cacaggtgac cgtgagctcc      420

ggaggaggag gatctcaggt gcagctggag gagtccggag gaggatctgt gcaggcagga      480

ggcagcctga ggctgtcctg tgcctacaca tatagcacct actccaacta ctatatggga      540

tggtttaggg aggcaccagg caaggcccgg acatctgtgg ccatcatctc tagcgacacc      600

acaatcacct acaaggatgc cgtgaagggc agattcacaa tcagcaagga caacgccaag      660

aataccctgt atctgcagat gaatagcctg aagcctgagg actccgccat gtacaggtgc      720

gccgcctgga catctgattg gagcgtggcc tattggggcc agggcacaca ggtgaccgtg      780

tcctctacca gcaccacaac ccctgcacca aggccaccta caccagcacc taccatcgcc      840

tctcagcctc tgagcctgag accagaggcc tgtaggccag cagcaggagg agcagtgcac      900

acccggggcc tggacttcgc ctgcgatatc tacatctggg caccactggc aggaacatgt      960

ggagtgctgc tgctgagcct ggtcatcacc ctgtactgca agagaggcag gaagaagctg     1020

ctgtatatct ttaagcagcc attcatgcgc cccgtgcaga caacccagga ggaggacggc     1080

tgctcctgtc ggtttccaga agaggaggag ggaggatgtg agctgagggt gaagttcagc     1140

aggtccgcag atgcaccagc ataccagcag ggccagaatc agctgtataa cgagctgaat     1200

ctgggccgga gagaggagta tgacgtgctg gataagagga ggggaaggga tccagagatg     1260

ggaggcaagc ctcggagaaa gaacccacag gagggcctgt acaatgagct gcagaaggac     1320

aagatggccg aggcctatag cgagatcggc atgaagggag agaggaggag gggcaaggga     1380

cacgatggcc tgtaccaggg cctgtccaca gccaccaagg acacctatga tgccctgcac     1440

atgcaggccc tgccaccccg gtaactcaca caaaaaacca acacacagat gtaatgaaaa     1500

taaagatatt ttattttagt gctcctttgt gcccatcagg atcttattcc aacaggtctt     1560

gatctcctgc agcagccgct tcaggaagca caggtcattc agcttcttct gctccttcag     1620

agacttgttc tcctccaggg actttgtggg ctgggcctct cccagtgctg ctggcttcct     1680

tcccttcacc tggccggtac agttcagcag gattgtggtg ccctcggaca ccttcagcag     1740

gtgcagatcg aagtcgccgg tgctattcat cttcagaaac tgcctcagct ttctggcggc     1800

ccgaaacagg aacatgccct ccttgttggc atcacagatg tgccgcttaa agaaattaaa     1860

ctcattgttc aggcagttgc tgccgatctc cttcatagaa tccagcagct ggtcgatgga     1920

caccatcagc acgctctcat actgcttaga gtccttgccc tcgatatcgc agtcggagct     1980

tgccactggc agcagcacca ggatcagagg gggcaggccg aagatgtacc taaaagacac     2040

gtggaacatg gctctgtctc aggtcagtat agaagctttg atgtgaagtc agccaagaac     2100

agctgaacac tacttctgct gaggcccttt tataggaggg attgcttcct gtgaataata     2160

ggaggatatt gtccacatcc agtaaagagg aaatccccaa ctgcatccaa aaagttttct     2220

gggaatatcc actgctgcag gagtggaaag tccccagtgg aaagtcccca gtggaaagtc     2280

ccca                                                                  2284


<210>  9
<211>  2258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1458)
<223>  anti-CD19 CAR coding sequence

<220>
<221>  misc_feature
<222>  (1516)..(2001)
<223>  complement of IL-15 coding sequence

<220>
<221>  misc_feature
<222>  (2194)..(2258)
<223>  3NF-kB/3AP-1

<400>  9
atggcactgc ctgtgaccgc actgctgctg ccactggcac tgctgctgca cgcagcaagg       60

ccagacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gcagggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagca ggctgcactc cggagtgcct      240

tctcggttca gcggatccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggaagcg gcggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggac tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg actggagtgg ctgggcgtga tctggggcag cgagaccaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctagg ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgagacc cgaggcctgt aggcctgcag caggaggagc agtgcacacc      900

aggggactgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtgga      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggcaggaa gaagctgctg     1020

tacatcttca agcagccttt tatgagacca gtgcagacaa cccaggagga ggacggctgc     1080

agctgtaggt tcccagaaga ggaggaggga ggatgtgagc tgagggtgaa gttttctcgg     1140

agcgcagatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggccggagag aggagtacga cgtgctggat aagaggcgcg gcagagatcc tgagatgggc     1260

ggcaagccac ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagaga ggaggagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc cctgcacatg     1440

caggccctgc ctccaaggta actcacacaa aaaaccaaca cacagatgta atgaaaataa     1500

agatatttta ttttaggatg tattgatgaa catctgcacg atgtgcacaa agctctgcag     1560

gaactccttg atgttcttct cctccagctc ctcacactcc ttgcagccgc tctctgtcac     1620

attgccgttg gagctcagag aattgttggc caggatgatc agattctcca cggtatcgtg     1680

gatagaggcg tcgccagact ccagggagat gacctgcagc tccagcagaa aacacttcat     1740

ggcggtcacc ttgcaggaag ggtgcacatc gctctctgta tacagggtgg cgtcgatgtg     1800

catagactgg atcagatcct cgatcttctt caggtcggag atcacattca cccagttggc     1860

ctctgtcttg ggcaggccgg cgctaaagca gcccaggatg aacacgtgga tgccggcctc     1920

ggtcaggaag tgagagttca gcagcagaca caggtagcac tggatgctga tagatctcag     1980

gtggggcttg gagatccgca tggctctgtc tcaggtcagt atagaagctt tgatgtgaag     2040

tcagccaaga acagctgaac actacttctg ctgaggccct tttataggag ggattgcttc     2100

ctgtgaataa taggaggata ttgtccacat ccagtaaaga ggaaatcccc aactgcatcc     2160

aaaaagtttt ctgggaatat ccactgctgc aggtgactca ctgagtcagt gactcaagtg     2220

gaaagtcccc agtggaaagt ccccagtgga aagtcccc                             2258


<210>  10
<211>  2303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1458)
<223>  anti-CD19 CAR coding sequence

<220>
<221>  misc_feature
<222>  (1516)..(2046)
<223>  complement of IL-7 coding sequence

<220>
<221>  misc_feature
<222>  (2239)..(2303)
<223>  3NF-kB/3AP-1

<400>  10
atggcactgc ctgtgaccgc actgctgctg ccactggcac tgctgctgca cgcagcaagg       60

ccagacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gcagggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagca ggctgcactc cggagtgcct      240

tctcggttca gcggatccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggaagcg gcggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggac tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg actggagtgg ctgggcgtga tctggggcag cgagaccaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctagg ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgagacc cgaggcctgt aggcctgcag caggaggagc agtgcacacc      900

aggggactgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtgga      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggcaggaa gaagctgctg     1020

tacatcttca agcagccttt tatgagacca gtgcagacaa cccaggagga ggacggctgc     1080

agctgtaggt tcccagaaga ggaggaggga ggatgtgagc tgagggtgaa gttttctcgg     1140

agcgcagatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggccggagag aggagtacga cgtgctggat aagaggcgcg gcagagatcc tgagatgggc     1260

ggcaagccac ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagaga ggaggagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc cctgcacatg     1440

caggccctgc ctccaaggta actcacacaa aaaaccaaca cacagatgta atgaaaataa     1500

agatatttta ttttagtgct cctttgtgcc catcaggatc ttattccaac aggtcttgat     1560

ctcctgcagc agccgcttca ggaagcacag gtcattcagc ttcttctgct ccttcagaga     1620

cttgttctcc tccagggact ttgtgggctg ggcctctccc agtgctgctg gcttccttcc     1680

cttcacctgg ccggtacagt tcagcaggat tgtggtgccc tcggacacct tcagcaggtg     1740

cagatcgaag tcgccggtgc tattcatctt cagaaactgc ctcagctttc tggcggcccg     1800

aaacaggaac atgccctcct tgttggcatc acagatgtgc cgcttaaaga aattaaactc     1860

attgttcagg cagttgctgc cgatctcctt catagaatcc agcagctggt cgatggacac     1920

catcagcacg ctctcatact gcttagagtc cttgccctcg atatcgcagt cggagcttgc     1980

cactggcagc agcaccagga tcagaggggg caggccgaag atgtacctaa aagacacgtg     2040

gaacatggct ctgtctcagg tcagtataga agctttgatg tgaagtcagc caagaacagc     2100

tgaacactac ttctgctgag gcccttttat aggagggatt gcttcctgtg aataatagga     2160

ggatattgtc cacatccagt aaagaggaaa tccccaactg catccaaaaa gttttctggg     2220

aatatccact gctgcaggtg actcactgag tcagtgactc aagtggaaag tccccagtgg     2280

aaagtcccca gtggaaagtc ccc                                             2303


<210>  11
<211>  2261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1461)
<223>  anti-BCMA CAR coding sequence

<220>
<221>  misc_feature
<222>  (1519)..(2004)
<223>  complement of IL-15 coding sequence

<220>
<221>  misc_feature
<222>  (2197)..(2261)
<223>  3NF-kB/3AP-1

<400>  11
atggcactgc cagtgacagc actgctgctg cctctggcac tgctgctgca cgcagcaagg       60

cctgccgtgc agctggtgga gtccggcggc ggcctggtgc aggccggcga ctctctgaga      120

ctgacatgca ccgcctccgg cagggccttc tctacatact ttatggcctg gttcagacag      180

gccccaggca aggagaggga gtttgtggca ggaatcgcat ggtctggagg aagcaccgca      240

tacgcagact ctgtgaaggg ccgcttcaca atcagccggg ataacgccaa gaataccgtg      300

tatctgcaga tgaactccct gaagtctgag gataccgccg tgtactattg cgcctccaga      360

ggcatcgagg tggaggagtt tggagcatgg ggacagggaa cacaggtgac cgtgagctcc      420

ggaggaggag gatctcaggt gcagctggag gagtccggag gaggatctgt gcaggcagga      480

ggcagcctga ggctgtcctg tgcctacaca tatagcacct actccaacta ctatatggga      540

tggtttaggg aggcaccagg caaggcccgg acatctgtgg ccatcatctc tagcgacacc      600

acaatcacct acaaggatgc cgtgaagggc agattcacaa tcagcaagga caacgccaag      660

aataccctgt atctgcagat gaatagcctg aagcctgagg actccgccat gtacaggtgc      720

gccgcctgga catctgattg gagcgtggcc tattggggcc agggcacaca ggtgaccgtg      780

tcctctacca gcaccacaac ccctgcacca aggccaccta caccagcacc taccatcgcc      840

tctcagcctc tgagcctgag accagaggcc tgtaggccag cagcaggagg agcagtgcac      900

acccggggcc tggacttcgc ctgcgatatc tacatctggg caccactggc aggaacatgt      960

ggagtgctgc tgctgagcct ggtcatcacc ctgtactgca agagaggcag gaagaagctg     1020

ctgtatatct ttaagcagcc attcatgcgc cccgtgcaga caacccagga ggaggacggc     1080

tgctcctgtc ggtttccaga agaggaggag ggaggatgtg agctgagggt gaagttcagc     1140

aggtccgcag atgcaccagc ataccagcag ggccagaatc agctgtataa cgagctgaat     1200

ctgggccgga gagaggagta tgacgtgctg gataagagga ggggaaggga tccagagatg     1260

ggaggcaagc ctcggagaaa gaacccacag gagggcctgt acaatgagct gcagaaggac     1320

aagatggccg aggcctatag cgagatcggc atgaagggag agaggaggag gggcaaggga     1380

cacgatggcc tgtaccaggg cctgtccaca gccaccaagg acacctatga tgccctgcac     1440

atgcaggccc tgccaccccg gtaactcaca caaaaaacca acacacagat gtaatgaaaa     1500

taaagatatt ttattttagg atgtattgat gaacatctgc acgatgtgca caaagctctg     1560

caggaactcc ttgatgttct tctcctccag ctcctcacac tccttgcagc cgctctctgt     1620

cacattgccg ttggagctca gagaattgtt ggccaggatg atcagattct ccacggtatc     1680

gtggatagag gcgtcgccag actccaggga gatgacctgc agctccagca gaaaacactt     1740

catggcggtc accttgcagg aagggtgcac atcgctctct gtatacaggg tggcgtcgat     1800

gtgcatagac tggatcagat cctcgatctt cttcaggtcg gagatcacat tcacccagtt     1860

ggcctctgtc ttgggcaggc cggcgctaaa gcagcccagg atgaacacgt ggatgccggc     1920

ctcggtcagg aagtgagagt tcagcagcag acacaggtag cactggatgc tgatagatct     1980

caggtggggc ttggagatcc gcatggctct gtctcaggtc agtatagaag ctttgatgtg     2040

aagtcagcca agaacagctg aacactactt ctgctgaggc ccttttatag gagggattgc     2100

ttcctgtgaa taataggagg atattgtcca catccagtaa agaggaaatc cccaactgca     2160

tccaaaaagt tttctgggaa tatccactgc tgcaggtgac tcactgagtc agtgactcaa     2220

gtggaaagtc cccagtggaa agtccccagt ggaaagtccc c                         2261


<210>  12
<211>  2306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1461)
<223>  anti-BCMA CAR coding sequence

<220>
<221>  misc_feature
<222>  (1519)..(2049)
<223>  complement of IL7 coding sequence

<220>
<221>  misc_feature
<222>  (2242)..(2306)
<223>  3NF-kB/3AP-1

<400>  12
atggcactgc cagtgacagc actgctgctg cctctggcac tgctgctgca cgcagcaagg       60

cctgccgtgc agctggtgga gtccggcggc ggcctggtgc aggccggcga ctctctgaga      120

ctgacatgca ccgcctccgg cagggccttc tctacatact ttatggcctg gttcagacag      180

gccccaggca aggagaggga gtttgtggca ggaatcgcat ggtctggagg aagcaccgca      240

tacgcagact ctgtgaaggg ccgcttcaca atcagccggg ataacgccaa gaataccgtg      300

tatctgcaga tgaactccct gaagtctgag gataccgccg tgtactattg cgcctccaga      360

ggcatcgagg tggaggagtt tggagcatgg ggacagggaa cacaggtgac cgtgagctcc      420

ggaggaggag gatctcaggt gcagctggag gagtccggag gaggatctgt gcaggcagga      480

ggcagcctga ggctgtcctg tgcctacaca tatagcacct actccaacta ctatatggga      540

tggtttaggg aggcaccagg caaggcccgg acatctgtgg ccatcatctc tagcgacacc      600

acaatcacct acaaggatgc cgtgaagggc agattcacaa tcagcaagga caacgccaag      660

aataccctgt atctgcagat gaatagcctg aagcctgagg actccgccat gtacaggtgc      720

gccgcctgga catctgattg gagcgtggcc tattggggcc agggcacaca ggtgaccgtg      780

tcctctacca gcaccacaac ccctgcacca aggccaccta caccagcacc taccatcgcc      840

tctcagcctc tgagcctgag accagaggcc tgtaggccag cagcaggagg agcagtgcac      900

acccggggcc tggacttcgc ctgcgatatc tacatctggg caccactggc aggaacatgt      960

ggagtgctgc tgctgagcct ggtcatcacc ctgtactgca agagaggcag gaagaagctg     1020

ctgtatatct ttaagcagcc attcatgcgc cccgtgcaga caacccagga ggaggacggc     1080

tgctcctgtc ggtttccaga agaggaggag ggaggatgtg agctgagggt gaagttcagc     1140

aggtccgcag atgcaccagc ataccagcag ggccagaatc agctgtataa cgagctgaat     1200

ctgggccgga gagaggagta tgacgtgctg gataagagga ggggaaggga tccagagatg     1260

ggaggcaagc ctcggagaaa gaacccacag gagggcctgt acaatgagct gcagaaggac     1320

aagatggccg aggcctatag cgagatcggc atgaagggag agaggaggag gggcaaggga     1380

cacgatggcc tgtaccaggg cctgtccaca gccaccaagg acacctatga tgccctgcac     1440

atgcaggccc tgccaccccg gtaactcaca caaaaaacca acacacagat gtaatgaaaa     1500

taaagatatt ttattttagt gctcctttgt gcccatcagg atcttattcc aacaggtctt     1560

gatctcctgc agcagccgct tcaggaagca caggtcattc agcttcttct gctccttcag     1620

agacttgttc tcctccaggg actttgtggg ctgggcctct cccagtgctg ctggcttcct     1680

tcccttcacc tggccggtac agttcagcag gattgtggtg ccctcggaca ccttcagcag     1740

gtgcagatcg aagtcgccgg tgctattcat cttcagaaac tgcctcagct ttctggcggc     1800

ccgaaacagg aacatgccct ccttgttggc atcacagatg tgccgcttaa agaaattaaa     1860

ctcattgttc aggcagttgc tgccgatctc cttcatagaa tccagcagct ggtcgatgga     1920

caccatcagc acgctctcat actgcttaga gtccttgccc tcgatatcgc agtcggagct     1980

tgccactggc agcagcacca ggatcagagg gggcaggccg aagatgtacc taaaagacac     2040

gtggaacatg gctctgtctc aggtcagtat agaagctttg atgtgaagtc agccaagaac     2100

agctgaacac tacttctgct gaggcccttt tataggaggg attgcttcct gtgaataata     2160

ggaggatatt gtccacatcc agtaaagagg aaatccccaa ctgcatccaa aaagttttct     2220

gggaatatcc actgctgcag gtgactcact gagtcagtga ctcaagtgga aagtccccag     2280

tggaaagtcc ccagtggaaa gtcccc                                          2306


<210>  13
<211>  2264
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1458)
<223>  anti-CD19 CAR coding sequence

<220>
<221>  misc_feature
<222>  (1516)..(2001)
<223>  complement of IL-15 coding sequence

<220>
<221>  misc_feature
<222>  (2194)..(2263)
<223>  5NF-kB

<400>  13
atggcactgc ctgtgaccgc actgctgctg ccactggcac tgctgctgca cgcagcaagg       60

ccagacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gcagggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagca ggctgcactc cggagtgcct      240

tctcggttca gcggatccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggaagcg gcggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggac tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg actggagtgg ctgggcgtga tctggggcag cgagaccaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctagg ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgagacc cgaggcctgt aggcctgcag caggaggagc agtgcacacc      900

aggggactgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtgga      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggcaggaa gaagctgctg     1020

tacatcttca agcagccttt tatgagacca gtgcagacaa cccaggagga ggacggctgc     1080

agctgtaggt tcccagaaga ggaggaggga ggatgtgagc tgagggtgaa gttttctcgg     1140

agcgcagatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggccggagag aggagtacga cgtgctggat aagaggcgcg gcagagatcc tgagatgggc     1260

ggcaagccac ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagaga ggaggagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc cctgcacatg     1440

caggccctgc ctccaaggta actcacacaa aaaaccaaca cacagatgta atgaaaataa     1500

agatatttta ttttaggatg tattgatgaa catctgcacg atgtgcacaa agctctgcag     1560

gaactccttg atgttcttct cctccagctc ctcacactcc ttgcagccgc tctctgtcac     1620

attgccgttg gagctcagag aattgttggc caggatgatc agattctcca cggtatcgtg     1680

gatagaggcg tcgccagact ccagggagat gacctgcagc tccagcagaa aacacttcat     1740

ggcggtcacc ttgcaggaag ggtgcacatc gctctctgta tacagggtgg cgtcgatgtg     1800

catagactgg atcagatcct cgatcttctt caggtcggag atcacattca cccagttggc     1860

ctctgtcttg ggcaggccgg cgctaaagca gcccaggatg aacacgtgga tgccggcctc     1920

ggtcaggaag tgagagttca gcagcagaca caggtagcac tggatgctga tagatctcag     1980

gtggggcttg gagatccgca tggctctgtc tcaggtcagt atagaagctt tgatgtgaag     2040

tcagccaaga acagctgaac actacttctg ctgaggccct tttataggag ggattgcttc     2100

ctgtgaataa taggaggata ttgtccacat ccagtaaaga ggaaatcccc aactgcatcc     2160

aaaaagtttt ctgggaatat ccactgctgc aggagtggaa agtccccagt ggaaagtccc     2220

cagtggaaag tccccagtgg aaagtcccca gtggaaagtc ccca                      2264


<210>  14
<211>  2309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1458)
<223>  anti-CD19 CAR coding sequence

<220>
<221>  misc_feature
<222>  (1516)..(2046)
<223>  complement of IL-7 coding sequence

<220>
<221>  misc_feature
<222>  (2239)..(2308)
<223>  5NF-kB

<400>  14
atggcactgc ctgtgaccgc actgctgctg ccactggcac tgctgctgca cgcagcaagg       60

ccagacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gcagggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagca ggctgcactc cggagtgcct      240

tctcggttca gcggatccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggaagcg gcggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggac tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg actggagtgg ctgggcgtga tctggggcag cgagaccaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctagg ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgagacc cgaggcctgt aggcctgcag caggaggagc agtgcacacc      900

aggggactgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtgga      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggcaggaa gaagctgctg     1020

tacatcttca agcagccttt tatgagacca gtgcagacaa cccaggagga ggacggctgc     1080

agctgtaggt tcccagaaga ggaggaggga ggatgtgagc tgagggtgaa gttttctcgg     1140

agcgcagatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggccggagag aggagtacga cgtgctggat aagaggcgcg gcagagatcc tgagatgggc     1260

ggcaagccac ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagaga ggaggagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc cctgcacatg     1440

caggccctgc ctccaaggta actcacacaa aaaaccaaca cacagatgta atgaaaataa     1500

agatatttta ttttagtgct cctttgtgcc catcaggatc ttattccaac aggtcttgat     1560

ctcctgcagc agccgcttca ggaagcacag gtcattcagc ttcttctgct ccttcagaga     1620

cttgttctcc tccagggact ttgtgggctg ggcctctccc agtgctgctg gcttccttcc     1680

cttcacctgg ccggtacagt tcagcaggat tgtggtgccc tcggacacct tcagcaggtg     1740

cagatcgaag tcgccggtgc tattcatctt cagaaactgc ctcagctttc tggcggcccg     1800

aaacaggaac atgccctcct tgttggcatc acagatgtgc cgcttaaaga aattaaactc     1860

attgttcagg cagttgctgc cgatctcctt catagaatcc agcagctggt cgatggacac     1920

catcagcacg ctctcatact gcttagagtc cttgccctcg atatcgcagt cggagcttgc     1980

cactggcagc agcaccagga tcagaggggg caggccgaag atgtacctaa aagacacgtg     2040

gaacatggct ctgtctcagg tcagtataga agctttgatg tgaagtcagc caagaacagc     2100

tgaacactac ttctgctgag gcccttttat aggagggatt gcttcctgtg aataatagga     2160

ggatattgtc cacatccagt aaagaggaaa tccccaactg catccaaaaa gttttctggg     2220

aatatccact gctgcaggag tggaaagtcc ccagtggaaa gtccccagtg gaaagtcccc     2280

agtggaaagt ccccagtgga aagtcccca                                       2309


<210>  15
<211>  2267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1461)
<223>  anti-BCMA CAR coding sequence

<220>
<221>  misc_feature
<222>  (1519)..(2004)
<223>  complement of IL-15 coding sequence

<220>
<221>  misc_feature
<222>  (2197)..(2266)
<223>  5NF-kB

<400>  15
atggcactgc cagtgacagc actgctgctg cctctggcac tgctgctgca cgcagcaagg       60

cctgccgtgc agctggtgga gtccggcggc ggcctggtgc aggccggcga ctctctgaga      120

ctgacatgca ccgcctccgg cagggccttc tctacatact ttatggcctg gttcagacag      180

gccccaggca aggagaggga gtttgtggca ggaatcgcat ggtctggagg aagcaccgca      240

tacgcagact ctgtgaaggg ccgcttcaca atcagccggg ataacgccaa gaataccgtg      300

tatctgcaga tgaactccct gaagtctgag gataccgccg tgtactattg cgcctccaga      360

ggcatcgagg tggaggagtt tggagcatgg ggacagggaa cacaggtgac cgtgagctcc      420

ggaggaggag gatctcaggt gcagctggag gagtccggag gaggatctgt gcaggcagga      480

ggcagcctga ggctgtcctg tgcctacaca tatagcacct actccaacta ctatatggga      540

tggtttaggg aggcaccagg caaggcccgg acatctgtgg ccatcatctc tagcgacacc      600

acaatcacct acaaggatgc cgtgaagggc agattcacaa tcagcaagga caacgccaag      660

aataccctgt atctgcagat gaatagcctg aagcctgagg actccgccat gtacaggtgc      720

gccgcctgga catctgattg gagcgtggcc tattggggcc agggcacaca ggtgaccgtg      780

tcctctacca gcaccacaac ccctgcacca aggccaccta caccagcacc taccatcgcc      840

tctcagcctc tgagcctgag accagaggcc tgtaggccag cagcaggagg agcagtgcac      900

acccggggcc tggacttcgc ctgcgatatc tacatctggg caccactggc aggaacatgt      960

ggagtgctgc tgctgagcct ggtcatcacc ctgtactgca agagaggcag gaagaagctg     1020

ctgtatatct ttaagcagcc attcatgcgc cccgtgcaga caacccagga ggaggacggc     1080

tgctcctgtc ggtttccaga agaggaggag ggaggatgtg agctgagggt gaagttcagc     1140

aggtccgcag atgcaccagc ataccagcag ggccagaatc agctgtataa cgagctgaat     1200

ctgggccgga gagaggagta tgacgtgctg gataagagga ggggaaggga tccagagatg     1260

ggaggcaagc ctcggagaaa gaacccacag gagggcctgt acaatgagct gcagaaggac     1320

aagatggccg aggcctatag cgagatcggc atgaagggag agaggaggag gggcaaggga     1380

cacgatggcc tgtaccaggg cctgtccaca gccaccaagg acacctatga tgccctgcac     1440

atgcaggccc tgccaccccg gtaactcaca caaaaaacca acacacagat gtaatgaaaa     1500

taaagatatt ttattttagg atgtattgat gaacatctgc acgatgtgca caaagctctg     1560

caggaactcc ttgatgttct tctcctccag ctcctcacac tccttgcagc cgctctctgt     1620

cacattgccg ttggagctca gagaattgtt ggccaggatg atcagattct ccacggtatc     1680

gtggatagag gcgtcgccag actccaggga gatgacctgc agctccagca gaaaacactt     1740

catggcggtc accttgcagg aagggtgcac atcgctctct gtatacaggg tggcgtcgat     1800

gtgcatagac tggatcagat cctcgatctt cttcaggtcg gagatcacat tcacccagtt     1860

ggcctctgtc ttgggcaggc cggcgctaaa gcagcccagg atgaacacgt ggatgccggc     1920

ctcggtcagg aagtgagagt tcagcagcag acacaggtag cactggatgc tgatagatct     1980

caggtggggc ttggagatcc gcatggctct gtctcaggtc agtatagaag ctttgatgtg     2040

aagtcagcca agaacagctg aacactactt ctgctgaggc ccttttatag gagggattgc     2100

ttcctgtgaa taataggagg atattgtcca catccagtaa agaggaaatc cccaactgca     2160

tccaaaaagt tttctgggaa tatccactgc tgcaggagtg gaaagtcccc agtggaaagt     2220

ccccagtgga aagtccccag tggaaagtcc ccagtggaaa gtcccca                   2267


<210>  16
<211>  2312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1461)
<223>  anti-BCMA CAR coding sequence

<220>
<221>  misc_feature
<222>  (1519)..(2049)
<223>  complement of IL-7 coding sequence

<220>
<221>  misc_feature
<222>  (2242)..(2311)
<223>  5NF-kB

<400>  16
atggcactgc cagtgacagc actgctgctg cctctggcac tgctgctgca cgcagcaagg       60

cctgccgtgc agctggtgga gtccggcggc ggcctggtgc aggccggcga ctctctgaga      120

ctgacatgca ccgcctccgg cagggccttc tctacatact ttatggcctg gttcagacag      180

gccccaggca aggagaggga gtttgtggca ggaatcgcat ggtctggagg aagcaccgca      240

tacgcagact ctgtgaaggg ccgcttcaca atcagccggg ataacgccaa gaataccgtg      300

tatctgcaga tgaactccct gaagtctgag gataccgccg tgtactattg cgcctccaga      360

ggcatcgagg tggaggagtt tggagcatgg ggacagggaa cacaggtgac cgtgagctcc      420

ggaggaggag gatctcaggt gcagctggag gagtccggag gaggatctgt gcaggcagga      480

ggcagcctga ggctgtcctg tgcctacaca tatagcacct actccaacta ctatatggga      540

tggtttaggg aggcaccagg caaggcccgg acatctgtgg ccatcatctc tagcgacacc      600

acaatcacct acaaggatgc cgtgaagggc agattcacaa tcagcaagga caacgccaag      660

aataccctgt atctgcagat gaatagcctg aagcctgagg actccgccat gtacaggtgc      720

gccgcctgga catctgattg gagcgtggcc tattggggcc agggcacaca ggtgaccgtg      780

tcctctacca gcaccacaac ccctgcacca aggccaccta caccagcacc taccatcgcc      840

tctcagcctc tgagcctgag accagaggcc tgtaggccag cagcaggagg agcagtgcac      900

acccggggcc tggacttcgc ctgcgatatc tacatctggg caccactggc aggaacatgt      960

ggagtgctgc tgctgagcct ggtcatcacc ctgtactgca agagaggcag gaagaagctg     1020

ctgtatatct ttaagcagcc attcatgcgc cccgtgcaga caacccagga ggaggacggc     1080

tgctcctgtc ggtttccaga agaggaggag ggaggatgtg agctgagggt gaagttcagc     1140

aggtccgcag atgcaccagc ataccagcag ggccagaatc agctgtataa cgagctgaat     1200

ctgggccgga gagaggagta tgacgtgctg gataagagga ggggaaggga tccagagatg     1260

ggaggcaagc ctcggagaaa gaacccacag gagggcctgt acaatgagct gcagaaggac     1320

aagatggccg aggcctatag cgagatcggc atgaagggag agaggaggag gggcaaggga     1380

cacgatggcc tgtaccaggg cctgtccaca gccaccaagg acacctatga tgccctgcac     1440

atgcaggccc tgccaccccg gtaactcaca caaaaaacca acacacagat gtaatgaaaa     1500

taaagatatt ttattttagt gctcctttgt gcccatcagg atcttattcc aacaggtctt     1560

gatctcctgc agcagccgct tcaggaagca caggtcattc agcttcttct gctccttcag     1620

agacttgttc tcctccaggg actttgtggg ctgggcctct cccagtgctg ctggcttcct     1680

tcccttcacc tggccggtac agttcagcag gattgtggtg ccctcggaca ccttcagcag     1740

gtgcagatcg aagtcgccgg tgctattcat cttcagaaac tgcctcagct ttctggcggc     1800

ccgaaacagg aacatgccct ccttgttggc atcacagatg tgccgcttaa agaaattaaa     1860

ctcattgttc aggcagttgc tgccgatctc cttcatagaa tccagcagct ggtcgatgga     1920

caccatcagc acgctctcat actgcttaga gtccttgccc tcgatatcgc agtcggagct     1980

tgccactggc agcagcacca ggatcagagg gggcaggccg aagatgtacc taaaagacac     2040

gtggaacatg gctctgtctc aggtcagtat agaagctttg atgtgaagtc agccaagaac     2100

agctgaacac tacttctgct gaggcccttt tataggaggg attgcttcct gtgaataata     2160

ggaggatatt gtccacatcc agtaaagagg aaatccccaa ctgcatccaa aaagttttct     2220

gggaatatcc actgctgcag gagtggaaag tccccagtgg aaagtcccca gtggaaagtc     2280

cccagtggaa agtccccagt ggaaagtccc ca                                   2312


<210>  17
<211>  2303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1458)
<223>  anti-CD19 CAR coding sequence

<220>
<221>  misc_feature
<222>  (1516)..(2001)
<223>  complement of IL-15 coding sequence

<220>
<221>  misc_feature
<222>  (2194)..(2303)
<223>  5NF-kB

<400>  17
atggcactgc ctgtgaccgc actgctgctg ccactggcac tgctgctgca cgcagcaagg       60

ccagacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gcagggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagca ggctgcactc cggagtgcct      240

tctcggttca gcggatccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggaagcg gcggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggac tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg actggagtgg ctgggcgtga tctggggcag cgagaccaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctagg ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgagacc cgaggcctgt aggcctgcag caggaggagc agtgcacacc      900

aggggactgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtgga      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggcaggaa gaagctgctg     1020

tacatcttca agcagccttt tatgagacca gtgcagacaa cccaggagga ggacggctgc     1080

agctgtaggt tcccagaaga ggaggaggga ggatgtgagc tgagggtgaa gttttctcgg     1140

agcgcagatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggccggagag aggagtacga cgtgctggat aagaggcgcg gcagagatcc tgagatgggc     1260

ggcaagccac ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagaga ggaggagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc cctgcacatg     1440

caggccctgc ctccaaggta actcacacaa aaaaccaaca cacagatgta atgaaaataa     1500

agatatttta ttttaggatg tattgatgaa catctgcacg atgtgcacaa agctctgcag     1560

gaactccttg atgttcttct cctccagctc ctcacactcc ttgcagccgc tctctgtcac     1620

attgccgttg gagctcagag aattgttggc caggatgatc agattctcca cggtatcgtg     1680

gatagaggcg tcgccagact ccagggagat gacctgcagc tccagcagaa aacacttcat     1740

ggcggtcacc ttgcaggaag ggtgcacatc gctctctgta tacagggtgg cgtcgatgtg     1800

catagactgg atcagatcct cgatcttctt caggtcggag atcacattca cccagttggc     1860

ctctgtcttg ggcaggccgg cgctaaagca gcccaggatg aacacgtgga tgccggcctc     1920

ggtcaggaag tgagagttca gcagcagaca caggtagcac tggatgctga tagatctcag     1980

gtggggcttg gagatccgca tggctctgtc tcaggtcagt atagaagctt tgatgtgaag     2040

tcagccaaga acagctgaac actacttctg ctgaggccct tttataggag ggattgcttc     2100

ctgtgaataa taggaggata ttgtccacat ccagtaaaga ggaaatcccc aactgcatcc     2160

aaaaagtttt ctgggaatat ccactgctgc aggcttactc actgagtcag tgactcactg     2220

agtcagtgac tcaagtggaa agtccccagt ggaaagtccc cagtggaaag tccccagtgg     2280

aaagtcccca gtggaaagtc ccc                                             2303


<210>  18
<211>  2348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1458)
<223>  anti-CD19 CAR coding sequence

<220>
<221>  misc_feature
<222>  (1516)..(2046)
<223>  complement of IL-7 coding sequence

<220>
<221>  misc_feature
<222>  (2239)..(2348)
<223>  5NF-kB/5AP-1

<400>  18
atggcactgc ctgtgaccgc actgctgctg ccactggcac tgctgctgca cgcagcaagg       60

ccagacatcc agatgacaca gaccacaagc tccctgtccg cctctctggg cgacagagtg      120

accatcagct gcagggcctc ccaggatatc tctaagtatc tgaactggta ccagcagaag      180

cccgatggca cagtgaagct gctgatctat cacaccagca ggctgcactc cggagtgcct      240

tctcggttca gcggatccgg ctctggcaca gactacagcc tgaccatctc caacctggag      300

caggaggata tcgccaccta tttctgccag cagggcaata cactgcctta cacctttggc      360

ggcggcacaa agctggagat caccggagga ggaggaagcg gcggaggagg ctccggcggc      420

ggcggctctg aggtgaagct gcaggagtcc ggaccaggac tggtggcacc tagccagtcc      480

ctgtctgtga catgtaccgt gtccggcgtg tctctgccag actacggcgt gtcttggatc      540

aggcagccac ctaggaaggg actggagtgg ctgggcgtga tctggggcag cgagaccaca      600

tactataatt ctgccctgaa gagcagactg acaatcatca aggacaacag caagtcccag      660

gtgttcctga agatgaatag cctgcagaca gacgataccg ccatctacta ttgcgccaag      720

cactactatt acggcggcag ctatgccatg gattactggg gccagggcac atccgtgacc      780

gtgtctagca ccacaacccc agcacctagg ccaccaacac cagcaccaac catcgcatcc      840

cagccactgt ctctgagacc cgaggcctgt aggcctgcag caggaggagc agtgcacacc      900

aggggactgg actttgcctg cgatatctat atctgggcac cactggcagg aacatgtgga      960

gtgctgctgc tgtccctggt catcaccctg tattgcaaga gaggcaggaa gaagctgctg     1020

tacatcttca agcagccttt tatgagacca gtgcagacaa cccaggagga ggacggctgc     1080

agctgtaggt tcccagaaga ggaggaggga ggatgtgagc tgagggtgaa gttttctcgg     1140

agcgcagatg caccagcata taagcaggga cagaaccagc tgtacaacga gctgaatctg     1200

ggccggagag aggagtacga cgtgctggat aagaggcgcg gcagagatcc tgagatgggc     1260

ggcaagccac ggagaaagaa cccccaggag ggcctgtata atgagctgca gaaggacaag     1320

atggccgagg cctactccga gatcggcatg aagggagaga ggaggagggg caagggacac     1380

gatggcctgt atcagggcct gtctacagcc accaaggaca cctacgatgc cctgcacatg     1440

caggccctgc ctccaaggta actcacacaa aaaaccaaca cacagatgta atgaaaataa     1500

agatatttta ttttagtgct cctttgtgcc catcaggatc ttattccaac aggtcttgat     1560

ctcctgcagc agccgcttca ggaagcacag gtcattcagc ttcttctgct ccttcagaga     1620

cttgttctcc tccagggact ttgtgggctg ggcctctccc agtgctgctg gcttccttcc     1680

cttcacctgg ccggtacagt tcagcaggat tgtggtgccc tcggacacct tcagcaggtg     1740

cagatcgaag tcgccggtgc tattcatctt cagaaactgc ctcagctttc tggcggcccg     1800

aaacaggaac atgccctcct tgttggcatc acagatgtgc cgcttaaaga aattaaactc     1860

attgttcagg cagttgctgc cgatctcctt catagaatcc agcagctggt cgatggacac     1920

catcagcacg ctctcatact gcttagagtc cttgccctcg atatcgcagt cggagcttgc     1980

cactggcagc agcaccagga tcagaggggg caggccgaag atgtacctaa aagacacgtg     2040

gaacatggct ctgtctcagg tcagtataga agctttgatg tgaagtcagc caagaacagc     2100

tgaacactac ttctgctgag gcccttttat aggagggatt gcttcctgtg aataatagga     2160

ggatattgtc cacatccagt aaagaggaaa tccccaactg catccaaaaa gttttctggg     2220

aatatccact gctgcaggct tactcactga gtcagtgact cactgagtca gtgactcaag     2280

tggaaagtcc ccagtggaaa gtccccagtg gaaagtcccc agtggaaagt ccccagtgga     2340

aagtcccc                                                              2348


<210>  19
<211>  2306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1461)
<223>  anti-BCMA CAR coding sequence

<220>
<221>  misc_feature
<222>  (1519)..(2004)
<223>  complement of IL-15 coding sequence

<220>
<221>  misc_feature
<222>  (2197)..(2306)
<223>  5NF-kB/5AP-1

<400>  19
atggcactgc cagtgacagc actgctgctg cctctggcac tgctgctgca cgcagcaagg       60

cctgccgtgc agctggtgga gtccggcggc ggcctggtgc aggccggcga ctctctgaga      120

ctgacatgca ccgcctccgg cagggccttc tctacatact ttatggcctg gttcagacag      180

gccccaggca aggagaggga gtttgtggca ggaatcgcat ggtctggagg aagcaccgca      240

tacgcagact ctgtgaaggg ccgcttcaca atcagccggg ataacgccaa gaataccgtg      300

tatctgcaga tgaactccct gaagtctgag gataccgccg tgtactattg cgcctccaga      360

ggcatcgagg tggaggagtt tggagcatgg ggacagggaa cacaggtgac cgtgagctcc      420

ggaggaggag gatctcaggt gcagctggag gagtccggag gaggatctgt gcaggcagga      480

ggcagcctga ggctgtcctg tgcctacaca tatagcacct actccaacta ctatatggga      540

tggtttaggg aggcaccagg caaggcccgg acatctgtgg ccatcatctc tagcgacacc      600

acaatcacct acaaggatgc cgtgaagggc agattcacaa tcagcaagga caacgccaag      660

aataccctgt atctgcagat gaatagcctg aagcctgagg actccgccat gtacaggtgc      720

gccgcctgga catctgattg gagcgtggcc tattggggcc agggcacaca ggtgaccgtg      780

tcctctacca gcaccacaac ccctgcacca aggccaccta caccagcacc taccatcgcc      840

tctcagcctc tgagcctgag accagaggcc tgtaggccag cagcaggagg agcagtgcac      900

acccggggcc tggacttcgc ctgcgatatc tacatctggg caccactggc aggaacatgt      960

ggagtgctgc tgctgagcct ggtcatcacc ctgtactgca agagaggcag gaagaagctg     1020

ctgtatatct ttaagcagcc attcatgcgc cccgtgcaga caacccagga ggaggacggc     1080

tgctcctgtc ggtttccaga agaggaggag ggaggatgtg agctgagggt gaagttcagc     1140

aggtccgcag atgcaccagc ataccagcag ggccagaatc agctgtataa cgagctgaat     1200

ctgggccgga gagaggagta tgacgtgctg gataagagga ggggaaggga tccagagatg     1260

ggaggcaagc ctcggagaaa gaacccacag gagggcctgt acaatgagct gcagaaggac     1320

aagatggccg aggcctatag cgagatcggc atgaagggag agaggaggag gggcaaggga     1380

cacgatggcc tgtaccaggg cctgtccaca gccaccaagg acacctatga tgccctgcac     1440

atgcaggccc tgccaccccg gtaactcaca caaaaaacca acacacagat gtaatgaaaa     1500

taaagatatt ttattttagg atgtattgat gaacatctgc acgatgtgca caaagctctg     1560

caggaactcc ttgatgttct tctcctccag ctcctcacac tccttgcagc cgctctctgt     1620

cacattgccg ttggagctca gagaattgtt ggccaggatg atcagattct ccacggtatc     1680

gtggatagag gcgtcgccag actccaggga gatgacctgc agctccagca gaaaacactt     1740

catggcggtc accttgcagg aagggtgcac atcgctctct gtatacaggg tggcgtcgat     1800

gtgcatagac tggatcagat cctcgatctt cttcaggtcg gagatcacat tcacccagtt     1860

ggcctctgtc ttgggcaggc cggcgctaaa gcagcccagg atgaacacgt ggatgccggc     1920

ctcggtcagg aagtgagagt tcagcagcag acacaggtag cactggatgc tgatagatct     1980

caggtggggc ttggagatcc gcatggctct gtctcaggtc agtatagaag ctttgatgtg     2040

aagtcagcca agaacagctg aacactactt ctgctgaggc ccttttatag gagggattgc     2100

ttcctgtgaa taataggagg atattgtcca catccagtaa agaggaaatc cccaactgca     2160

tccaaaaagt tttctgggaa tatccactgc tgcaggctta ctcactgagt cagtgactca     2220

ctgagtcagt gactcaagtg gaaagtcccc agtggaaagt ccccagtgga aagtccccag     2280

tggaaagtcc ccagtggaaa gtcccc                                          2306


<210>  20
<211>  2351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1461)
<223>  anti-BCMA CAR coding sequence

<220>
<221>  misc_feature
<222>  (1519)..(2049)
<223>  complement of IL-7 coding sequence

<220>
<221>  misc_feature
<222>  (2242)..(2351)
<223>  5NF-kB/5AP-1

<400>  20
atggcactgc cagtgacagc actgctgctg cctctggcac tgctgctgca cgcagcaagg       60

cctgccgtgc agctggtgga gtccggcggc ggcctggtgc aggccggcga ctctctgaga      120

ctgacatgca ccgcctccgg cagggccttc tctacatact ttatggcctg gttcagacag      180

gccccaggca aggagaggga gtttgtggca ggaatcgcat ggtctggagg aagcaccgca      240

tacgcagact ctgtgaaggg ccgcttcaca atcagccggg ataacgccaa gaataccgtg      300

tatctgcaga tgaactccct gaagtctgag gataccgccg tgtactattg cgcctccaga      360

ggcatcgagg tggaggagtt tggagcatgg ggacagggaa cacaggtgac cgtgagctcc      420

ggaggaggag gatctcaggt gcagctggag gagtccggag gaggatctgt gcaggcagga      480

ggcagcctga ggctgtcctg tgcctacaca tatagcacct actccaacta ctatatggga      540

tggtttaggg aggcaccagg caaggcccgg acatctgtgg ccatcatctc tagcgacacc      600

acaatcacct acaaggatgc cgtgaagggc agattcacaa tcagcaagga caacgccaag      660

aataccctgt atctgcagat gaatagcctg aagcctgagg actccgccat gtacaggtgc      720

gccgcctgga catctgattg gagcgtggcc tattggggcc agggcacaca ggtgaccgtg      780

tcctctacca gcaccacaac ccctgcacca aggccaccta caccagcacc taccatcgcc      840

tctcagcctc tgagcctgag accagaggcc tgtaggccag cagcaggagg agcagtgcac      900

acccggggcc tggacttcgc ctgcgatatc tacatctggg caccactggc aggaacatgt      960

ggagtgctgc tgctgagcct ggtcatcacc ctgtactgca agagaggcag gaagaagctg     1020

ctgtatatct ttaagcagcc attcatgcgc cccgtgcaga caacccagga ggaggacggc     1080

tgctcctgtc ggtttccaga agaggaggag ggaggatgtg agctgagggt gaagttcagc     1140

aggtccgcag atgcaccagc ataccagcag ggccagaatc agctgtataa cgagctgaat     1200

ctgggccgga gagaggagta tgacgtgctg gataagagga ggggaaggga tccagagatg     1260

ggaggcaagc ctcggagaaa gaacccacag gagggcctgt acaatgagct gcagaaggac     1320

aagatggccg aggcctatag cgagatcggc atgaagggag agaggaggag gggcaaggga     1380

cacgatggcc tgtaccaggg cctgtccaca gccaccaagg acacctatga tgccctgcac     1440

atgcaggccc tgccaccccg gtaactcaca caaaaaacca acacacagat gtaatgaaaa     1500

taaagatatt ttattttagt gctcctttgt gcccatcagg atcttattcc aacaggtctt     1560

gatctcctgc agcagccgct tcaggaagca caggtcattc agcttcttct gctccttcag     1620

agacttgttc tcctccaggg actttgtggg ctgggcctct cccagtgctg ctggcttcct     1680

tcccttcacc tggccggtac agttcagcag gattgtggtg ccctcggaca ccttcagcag     1740

gtgcagatcg aagtcgccgg tgctattcat cttcagaaac tgcctcagct ttctggcggc     1800

ccgaaacagg aacatgccct ccttgttggc atcacagatg tgccgcttaa agaaattaaa     1860

ctcattgttc aggcagttgc tgccgatctc cttcatagaa tccagcagct ggtcgatgga     1920

caccatcagc acgctctcat actgcttaga gtccttgccc tcgatatcgc agtcggagct     1980

tgccactggc agcagcacca ggatcagagg gggcaggccg aagatgtacc taaaagacac     2040

gtggaacatg gctctgtctc aggtcagtat agaagctttg atgtgaagtc agccaagaac     2100

agctgaacac tacttctgct gaggcccttt tataggaggg attgcttcct gtgaataata     2160

ggaggatatt gtccacatcc agtaaagagg aaatccccaa ctgcatccaa aaagttttct     2220

gggaatatcc actgctgcag gcttactcac tgagtcagtg actcactgag tcagtgactc     2280

aagtggaaag tccccagtgg aaagtcccca gtggaaagtc cccagtggaa agtccccagt     2340

ggaaagtccc c                                                          2351


<210>  21
<211>  486
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg 
                485     


<210>  22
<211>  487
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Ala Gly Asp Ser Leu Arg Leu Thr Cys Thr Ala Ser Gly Arg 
        35                  40                  45              


Ala Phe Ser Thr Tyr Phe Met Ala Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Phe Val Ala Gly Ile Ala Trp Ser Gly Gly Ser Thr Ala 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Arg Gly Ile Glu Val Glu Glu Phe Gly 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Tyr Thr Tyr Ser Thr Tyr Ser Asn 
                165                 170                 175     


Tyr Tyr Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Ala Arg Thr Ser 
            180                 185                 190         


Val Ala Ile Ile Ser Ser Asp Thr Thr Ile Thr Tyr Lys Asp Ala Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Ser Ala Met Tyr Arg Cys 
225                 230                 235                 240 


Ala Ala Trp Thr Ser Asp Trp Ser Val Ala Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Thr Ser Thr Thr Thr Pro Ala Pro Arg Pro 
            260                 265                 270         


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
        275                 280                 285             


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
    290                 295                 300                 


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
305                 310                 315                 320 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  23
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Met Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr 
1               5                   10                  15      


Leu Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His 
            20                  25                  30          


Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
        35                  40                  45              


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
    50                  55                  60                  


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
65                  70                  75                  80  


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
                85                  90                  95      


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
            100                 105                 110         


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
        115                 120                 125             


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
    130                 135                 140                 


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
145                 150                 155                 160 


Thr Ser 
        


<210>  24
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Ser Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  25
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
ggggactttc cact                                                         14


<210>  26
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
ggggactttc cactggggac tttccactgg ggactttcca ct                          42


<210>  27
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
ggggactttc cactggggac tttccactgg ggactttcca ctggggactt tccactgggg       60

actttccact                                                              70


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  28
ggggactttc cacttgagtc a                                                 21


<210>  29
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  29
ggggactttc cactggggac tttccactgg ggactttcca cttgagtcac tgactcagtg       60

agtca                                                                   65


<210>  30
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  30
ggggactttc cactggggac tttccactgg ggactttcca ctggggactt tccactgggg       60

actttccact tgagtcactg actcagtgag tcatgagtca tgagtca                    107


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  32
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  33
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  34
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  35
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  36
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


<210>  37
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  38
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Phe Ser Gly Tyr Gly Val Ser 
            20                  25                  30          


Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Thr Val Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Val Gly Tyr Leu Ser Gly Gly Ser Trp Asp Val Pro Gly Arg Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
    130                 135                 140                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
145                 150                 155                 160 


Ser Cys Ala Ala Ser Gly Asn Thr Tyr Ser Ser Asn Tyr Met Gly Trp 
                165                 170                 175     


Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Glu Val Ala Val Ile Tyr 
            180                 185                 190         


Thr Arg Gly Gly His Thr Tyr Tyr Val Asp Ser Val Arg Gly Arg Phe 
        195                 200                 205             


Thr Ile Ser Gln Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
    210                 215                 220                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ser Ser 
225                 230                 235                 240 


Arg His Arg Leu Gly Leu Asn Asn Pro Arg Asp Tyr Asp Tyr Trp Gly 
                245                 250                 255     


Gln Gly Thr Leu Val Thr Val Ser Ser 
            260                 265 


<210>  39
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39
tggaaagat                                                                9


<210>  40
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40
tgagtca                                                                  7


<210>  41
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41
ggggactttc c                                                            11


<210>  42
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42
tggaaagatt ggaaagactg gaaagatagg aaacactgga aagag                       45


<210>  43
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43
tgagtcactg actcagtgag tcactgactc agtgagtaa                              39


<210>  44
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44
ggggactttc cactggggac tttccactgg ggactttcca ctggggactt tccactgggg       60

actttcc                                                                 67


<210>  45
<211>  163
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45
tggaaagatt ggaaagactg gaaagatagg aaacactgga aagaggtacc tgagtcactg       60

actcagtgag tcactgactc agtgagtaag aattctgggg actttccact ggggactttc      120

cactggggac tttccactgg ggactttcca ctggggactt tcc                        163


<210>  46
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (6)..(12)
<223>  TATA box

<400>  46
ttcgcatatt aaggtgacgc gtgtggcctc gaacaccgag cgaccctgca gcgacccgct       60

taa                                                                     63


<210>  47
<211>  404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (13)..(55)
<223>  5NFAT

<220>
<221>  misc_feature
<222>  (63)..(101)
<223>  5AP-1

<220>
<221>  misc_feature
<222>  (109)..(175)
<223>  5NF-kB

<220>
<221>  misc_feature
<222>  (204)..(222)
<223>  Sp1

<220>
<221>  misc_feature
<222>  (223)..(227)
<223>  CAAT box

<220>
<221>  misc_feature
<222>  (277)..(339)
<223>  miniTK

<400>  47
tctagatatc gctggaaaga ttggaaagac tggaaagata ggaaacactg gaaagaggta       60

cctgagtcac tgactcagtg agtcactgac tcagtgagta agaattctgg ggactttcca      120

ctggggactt tccactgggg actttccact ggggactttc cactggggac tttccactcc      180

tgcagggcta gctcgagatc cggccccgcc cagcgtcttg tcattggcga attcgaacac      240

gcagatgcag tcggggcggc gcggtccgag gtccacttcg catattaagg tgacgcgtgt      300

ggcctcgaac accgagcgac cctgcagcga cccgcttaac agcgtcaaca gcgtgccgca      360

gatctaagta agcttggcat tccggtactg ttggtaaagc cacc                       404


<210>  48
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  48
tctagagggt atataatggg ggcca                                             25


<210>  49
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  49
tctagatatc gctggaaaga ttggaaagac tggaaagata ggaaacactg gaaagaggta       60

cctgagtcac tgactcagtg agtcactgac tcagtgagta agaattctgg ggactttcca      120

ctggggactt tccactgggg actttccact ggggactttc cactggggac tttccactcc      180

tgcagggcta gctcgagatc cggccccgcc cagcgtcttg tcattggcga attcgaacac      240

gcagatgcag tcggggcggc gcggtccgag gtccactcta gagggtatat aatgggggcc      300

acagcgtcaa cagcgtgccg cagatctaag taagcttggc attccggtac tgttggtaaa      360

gccacc                                                                 366


<210>  50
<211>  2484
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  50
atggcactgc cagtgacagc cctgctgctg cctctggccc tgctgctgca cgccgcccgc       60

ccacaggtgc agctggtgga gagcggagga ggagtggtgc agccaggagg atctctgaga      120

ctgagctgcg cagcatcttt cagcggatac ggcgtgtcca ccatggcctg gtttaggcag      180

gcacctggca agggactgga gggagtggca gcaatcacag tgggatctgg caacacctac      240

tatgccgaca gcgtgaaggg ccgcttcaca atctcccggg ataactctaa gaataccgtg      300

tacctgcaga tgaattccct gagagccgag gacacagcca tgtactattg cgcagtggga      360

tatctgagcg gaggatcctg ggatgtgcca ggcaggtaca actattgggg ccagggcaca      420

ctggtgaccg tgagctccgg cggcggcggc tctggaggag gaggaagcgg aggaggagga      480

tccgaggtgc agctggtgga gtctggcggc ggcctggtgc agcccggcgg cagcctgcgc      540

ctgtcctgtg ccgcctctgg caacacctac tctagcaatt atatgggatg gttcagacag      600

gcccctggca agggcctgga ggaggtggcc gtgatctaca cacggggcgg ccacacctac      660

tatgtggaca gcgtgagagg caggtttaca atctctcagg ataacgccaa gaatagcctg      720

tatctgcaga tgaacagcct gagggcagag gacaccgccg tgtactattg cgcagcatcc      780

tctaggcaca ggctgggcct gaacaatcca cgcgactacg attactgggg acagggcaca      840

ctggtcaccg tgagctccac cacaacccct gcaccaaggc cacctacacc agcacctacc      900

atcgcaagcc agcctctgtc cctgagacca gaggcctgta ggccagcagc aggaggagca      960

gtgcacaccc ggggcctgga ctttgcctgc gatatctaca tctgggcacc actggcagga     1020

acatgtggcg tgctgctgct gtctctggtc atcaccctgt actgcaagag aggcaggaag     1080

aagctgctgt atatcttcaa gcagcccttc atgagacccg tgcagacaac ccaggaggag     1140

gacggctgca gctgtaggtt ccctgaagag gaggagggag gatgtgagct gagggtgaag     1200

ttttcccggt ctgccgatgc cccagcctac aagcagggcc agaaccagct gtataacgag     1260

ctgaatctgg gccggagaga ggagtacgac gtgctggata agaggagggg aagagatcca     1320

gagatgggag gcaagcctcg gagaaagaac ccacaggagg gcctgtacaa tgagctgcag     1380

aaggacaaga tggccgaggc ctattccgag atcggcatga agggagagag gcgccggggc     1440

aagggacacg atggcctgta ccagggcctg tctacagcca ccaaggacac ctatgatgcc     1500

ctgcacatgc aggccctgcc acccaggggc agcggcgcca ccaacttctc cctgctgaag     1560

caggcaggcg acgtggagga gaatcccggc cctatgttcc acgtgagctt tagatacatc     1620

ttcggcctgc cccctctgat cctggtgctg ctgccagtgg caagctccga ctgcgatatc     1680

gagggcaagg acggcaagca gtatgagtcc gtgctgatgg tgtctatcga ccagctgctg     1740

gatagcatga aggagatcgg ctccaactgc ctgaacaatg agtttaattt ctttaagagg     1800

cacatctgtg atgccaacaa ggagggcatg ttcctgtttc gggccgccag aaagctgagg     1860

cagtttctga agatgaattc taccggcgac ttcgatctgc acctgctgaa ggtgagcgag     1920

ggcaccacaa tcctgctgaa ctgtaccggc caggtgaagg gaaggaagcc tgccgccctg     1980

ggagaggcac agccaacaaa gtctctggag gagaacaaga gcctgaagga gcagaagaag     2040

ctgaatgacc tgtgctttct gaagcggctg ctgcaggaga tcaagacatg ttggaataag     2100

atcctgatgg gaaccaagga gcacggatcc ggagcaacaa acttctctct gctgaagcag     2160

gccggcgatg tggaggagaa tcctggacca atggcactgc tgctggccct gtccctgctg     2220

gtgctgtgga ccagcccagc acctaccctg tccggaacaa acgacgccga ggattgctgt     2280

ctgtctgtga cacagaagcc aatccccggc tacatcgtga gaaattttca ctatctgctg     2340

atcaaggacg gatgcagggt gccagcagtg gtgttcacca cactgagggg ccgccagctg     2400

tgcgcaccac cagatcagcc ttgggtggag cggatcatcc agcgcctgca gcggacctcc     2460

gccaagatga agcggagatc tagc                                            2484


<210>  51
<211>  2831
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  51
atggcactgc cagtgacagc cctgctgctg cctctggccc tgctgctgca cgccgcccgc       60

ccacaggtgc agctggtgga gagcggagga ggagtggtgc agccaggagg atctctgaga      120

ctgagctgcg cagcatcttt cagcggatac ggcgtgtcca ccatggcctg gtttaggcag      180

gcacctggca agggactgga gggagtggca gcaatcacag tgggatctgg caacacctac      240

tatgccgaca gcgtgaaggg ccgcttcaca atctcccggg ataactctaa gaataccgtg      300

tacctgcaga tgaattccct gagagccgag gacacagcca tgtactattg cgcagtggga      360

tatctgagcg gaggatcctg ggatgtgcca ggcaggtaca actattgggg ccagggcaca      420

ctggtgaccg tgagctccgg cggcggcggc tctggaggag gaggaagcgg aggaggagga      480

tccgaggtgc agctggtgga gtctggcggc ggcctggtgc agcccggcgg cagcctgcgc      540

ctgtcctgtg ccgcctctgg caacacctac tctagcaatt atatgggatg gttcagacag      600

gcccctggca agggcctgga ggaggtggcc gtgatctaca cacggggcgg ccacacctac      660

tatgtggaca gcgtgagagg caggtttaca atctctcagg ataacgccaa gaatagcctg      720

tatctgcaga tgaacagcct gagggcagag gacaccgccg tgtactattg cgcagcatcc      780

tctaggcaca ggctgggcct gaacaatcca cgcgactacg attactgggg acagggcaca      840

ctggtcaccg tgagctccac cacaacccct gcaccaaggc cacctacacc agcacctacc      900

atcgcaagcc agcctctgtc cctgagacca gaggcctgta ggccagcagc aggaggagca      960

gtgcacaccc ggggcctgga ctttgcctgc gatatctaca tctgggcacc actggcagga     1020

acatgtggcg tgctgctgct gtctctggtc atcaccctgt actgcaagag aggcaggaag     1080

aagctgctgt atatcttcaa gcagcccttc atgagacccg tgcagacaac ccaggaggag     1140

gacggctgca gctgtaggtt ccctgaagag gaggagggag gatgtgagct gagggtgaag     1200

ttttcccggt ctgccgatgc cccagcctac aagcagggcc agaaccagct gtataacgag     1260

ctgaatctgg gccggagaga ggagtacgac gtgctggata agaggagggg aagagatcca     1320

gagatgggag gcaagcctcg gagaaagaac ccacaggagg gcctgtacaa tgagctgcag     1380

aaggacaaga tggccgaggc ctattccgag atcggcatga agggagagag gcgccggggc     1440

aagggacacg atggcctgta ccagggcctg tctacagcca ccaaggacac ctatgatgcc     1500

ctgcacatgc aggccctgcc acccaggtaa tctagatatc gctggaaaga ttggaaagac     1560

tggaaagata ggaaacactg gaaagaggta cctgagtcac tgactcagtg agtcactgac     1620

tcagtgagta agaattctgg ggactttcca ctggggactt tccactgggg actttccact     1680

ggggactttc cactggggac tttccactcc tgcagggcta gctcgagatc cggccccgcc     1740

cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag     1800

gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga     1860

cccgcttaac agcgtcaaca gcgtgccgca gatctaagta agcttggcat tccggtactg     1920

ttggtaaagc caccgccacc atgttccacg tgagctttag atacatcttc ggcctgcccc     1980

ctctgatcct ggtgctgctg ccagtggcaa gctccgactg cgatatcgag ggcaaggacg     2040

gcaagcagta tgagtccgtg ctgatggtgt ctatcgacca gctgctggat agcatgaagg     2100

agatcggctc caactgcctg aacaatgagt ttaatttctt taagaggcac atctgtgatg     2160

ccaacaagga gggcatgttc ctgtttcggg ccgccagaaa gctgaggcag tttctgaaga     2220

tgaattctac cggcgacttc gatctgcacc tgctgaaggt gagcgagggc accacaatcc     2280

tgctgaactg taccggccag gtgaagggaa ggaagcctgc cgccctggga gaggcacagc     2340

caacaaagtc tctggaggag aacaagagcc tgaaggagca gaagaagctg aatgacctgt     2400

gctttctgaa gcggctgctg caggagatca agacatgttg gaataagatc ctgatgggaa     2460

ccaaggagca cggatccgga gcaacaaact tctctctgct gaagcaggcc ggcgatgtgg     2520

aggagaatcc tggaccaatg gcactgctgc tggccctgtc cctgctggtg ctgtggacca     2580

gcccagcacc taccctgtcc ggaacaaacg acgccgagga ttgctgtctg tctgtgacac     2640

agaagccaat ccccggctac atcgtgagaa attttcacta tctgctgatc aaggacggat     2700

gcagggtgcc agcagtggtg ttcaccacac tgaggggccg ccagctgtgc gcaccaccag     2760

atcagccttg ggtggagcgg atcatccagc gcctgcagcg gacctccgcc aagatgaagc     2820

ggagatctag c                                                          2831


<210>  52
<211>  2079
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  52
atggcactgc cagtgacagc cctgctgctg cctctggccc tgctgctgca cgccgcccgc       60

ccacaggtgc agctggtgga gagcggagga ggagtggtgc agccaggagg atctctgaga      120

ctgagctgcg cagcatcttt cagcggatac ggcgtgtcca ccatggcctg gtttaggcag      180

gcacctggca agggactgga gggagtggca gcaatcacag tgggatctgg caacacctac      240

tatgccgaca gcgtgaaggg ccgcttcaca atctcccggg ataactctaa gaataccgtg      300

tacctgcaga tgaattccct gagagccgag gacacagcca tgtactattg cgcagtggga      360

tatctgagcg gaggatcctg ggatgtgcca ggcaggtaca actattgggg ccagggcaca      420

ctggtgaccg tgagctccgg cggcggcggc tctggaggag gaggaagcgg aggaggagga      480

tccgaggtgc agctggtgga gtctggcggc ggcctggtgc agcccggcgg cagcctgcgc      540

ctgtcctgtg ccgcctctgg caacacctac tctagcaatt atatgggatg gttcagacag      600

gcccctggca agggcctgga ggaggtggcc gtgatctaca cacggggcgg ccacacctac      660

tatgtggaca gcgtgagagg caggtttaca atctctcagg ataacgccaa gaatagcctg      720

tatctgcaga tgaacagcct gagggcagag gacaccgccg tgtactattg cgcagcatcc      780

tctaggcaca ggctgggcct gaacaatcca cgcgactacg attactgggg acagggcaca      840

ctggtcaccg tgagctccac cacaacccct gcaccaaggc cacctacacc agcacctacc      900

atcgcaagcc agcctctgtc cctgagacca gaggcctgta ggccagcagc aggaggagca      960

gtgcacaccc ggggcctgga ctttgcctgc gatatctaca tctgggcacc actggcagga     1020

acatgtggcg tgctgctgct gtctctggtc atcaccctgt actgcaagag aggcaggaag     1080

aagctgctgt atatcttcaa gcagcccttc atgagacccg tgcagacaac ccaggaggag     1140

gacggctgca gctgtaggtt ccctgaagag gaggagggag gatgtgagct gagggtgaag     1200

ttttcccggt ctgccgatgc cccagcctac aagcagggcc agaaccagct gtataacgag     1260

ctgaatctgg gccggagaga ggagtacgac gtgctggata agaggagggg aagagatcca     1320

gagatgggag gcaagcctcg gagaaagaac ccacaggagg gcctgtacaa tgagctgcag     1380

aaggacaaga tggccgaggc ctattccgag atcggcatga agggagagag gcgccggggc     1440

aagggacacg atggcctgta ccagggcctg tctacagcca ccaaggacac ctatgatgcc     1500

ctgcacatgc aggccctgcc acccaggggc agcggcgcca ccaacttctc cctgctgaag     1560

caggcaggcg acgtggagga gaatcccggc cctatgcgga tctccaagcc ccacctgaga     1620

tctatcagca tccagtgcta cctgtgcctg ctgctgaact ctcacttcct gaccgaggcc     1680

ggcatccacg tgttcatcct gggctgcttt agcgccggcc tgcccaagac agaggccaac     1740

tgggtgaatg tgatctccga cctgaagaag atcgaggatc tgatccagtc tatgcacatc     1800

gacgccaccc tgtatacaga gagcgatgtg cacccttcct gcaaggtgac cgccatgaag     1860

tgttttctgc tggagctgca ggtcatctcc ctggagtctg gcgacgcctc tatccacgat     1920

accgtggaga atctgatcat cctggccaac aattctctga gctccaacgg caatgtgaca     1980

gagagcggct gcaaggagtg tgaggagctg gaggagaaga acatcaagga gttcctgcag     2040

agctttgtgc acatcgtgca gatgttcatc aatacatcc                            2079


<210>  53
<211>  2426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  53
atggcactgc cagtgacagc cctgctgctg cctctggccc tgctgctgca cgccgcccgc       60

ccacaggtgc agctggtgga gagcggagga ggagtggtgc agccaggagg atctctgaga      120

ctgagctgcg cagcatcttt cagcggatac ggcgtgtcca ccatggcctg gtttaggcag      180

gcacctggca agggactgga gggagtggca gcaatcacag tgggatctgg caacacctac      240

tatgccgaca gcgtgaaggg ccgcttcaca atctcccggg ataactctaa gaataccgtg      300

tacctgcaga tgaattccct gagagccgag gacacagcca tgtactattg cgcagtggga      360

tatctgagcg gaggatcctg ggatgtgcca ggcaggtaca actattgggg ccagggcaca      420

ctggtgaccg tgagctccgg cggcggcggc tctggaggag gaggaagcgg aggaggagga      480

tccgaggtgc agctggtgga gtctggcggc ggcctggtgc agcccggcgg cagcctgcgc      540

ctgtcctgtg ccgcctctgg caacacctac tctagcaatt atatgggatg gttcagacag      600

gcccctggca agggcctgga ggaggtggcc gtgatctaca cacggggcgg ccacacctac      660

tatgtggaca gcgtgagagg caggtttaca atctctcagg ataacgccaa gaatagcctg      720

tatctgcaga tgaacagcct gagggcagag gacaccgccg tgtactattg cgcagcatcc      780

tctaggcaca ggctgggcct gaacaatcca cgcgactacg attactgggg acagggcaca      840

ctggtcaccg tgagctccac cacaacccct gcaccaaggc cacctacacc agcacctacc      900

atcgcaagcc agcctctgtc cctgagacca gaggcctgta ggccagcagc aggaggagca      960

gtgcacaccc ggggcctgga ctttgcctgc gatatctaca tctgggcacc actggcagga     1020

acatgtggcg tgctgctgct gtctctggtc atcaccctgt actgcaagag aggcaggaag     1080

aagctgctgt atatcttcaa gcagcccttc atgagacccg tgcagacaac ccaggaggag     1140

gacggctgca gctgtaggtt ccctgaagag gaggagggag gatgtgagct gagggtgaag     1200

ttttcccggt ctgccgatgc cccagcctac aagcagggcc agaaccagct gtataacgag     1260

ctgaatctgg gccggagaga ggagtacgac gtgctggata agaggagggg aagagatcca     1320

gagatgggag gcaagcctcg gagaaagaac ccacaggagg gcctgtacaa tgagctgcag     1380

aaggacaaga tggccgaggc ctattccgag atcggcatga agggagagag gcgccggggc     1440

aagggacacg atggcctgta ccagggcctg tctacagcca ccaaggacac ctatgatgcc     1500

ctgcacatgc aggccctgcc acccaggtaa tctagatatc gctggaaaga ttggaaagac     1560

tggaaagata ggaaacactg gaaagaggta cctgagtcac tgactcagtg agtcactgac     1620

tcagtgagta agaattctgg ggactttcca ctggggactt tccactgggg actttccact     1680

ggggactttc cactggggac tttccactcc tgcagggcta gctcgagatc cggccccgcc     1740

cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag     1800

gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga     1860

cccgcttaac agcgtcaaca gcgtgccgca gatctaagta agcttggcat tccggtactg     1920

ttggtaaagc caccgccacc atgcggatct ccaagcccca cctgagatct atcagcatcc     1980

agtgctacct gtgcctgctg ctgaactctc acttcctgac cgaggccggc atccacgtgt     2040

tcatcctggg ctgctttagc gccggcctgc ccaagacaga ggccaactgg gtgaatgtga     2100

tctccgacct gaagaagatc gaggatctga tccagtctat gcacatcgac gccaccctgt     2160

atacagagag cgatgtgcac ccttcctgca aggtgaccgc catgaagtgt tttctgctgg     2220

agctgcaggt catctccctg gagtctggcg acgcctctat ccacgatacc gtggagaatc     2280

tgatcatcct ggccaacaat tctctgagct ccaacggcaa tgtgacagag agcggctgca     2340

aggagtgtga ggagctggag gagaagaaca tcaaggagtt cctgcagagc tttgtgcaca     2400

tcgtgcagat gttcatcaat acatcc                                          2426


<210>  54
<211>  376
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  54
agcttgaata aaatgaatat tagaagctgt tagaataaga gaaaatgaca gaggaaaact       60

gaaagggaga actgaaagtg ggaaattcct ctgaggcaga aaggaccatc ccttataaat      120

agcacaggcc atgaaggaag atcattctca ctgcagcctt tgacagcctt tgcctcatct      180

tgaagcttct gccttctccc tcctgtgagt ttggtaagtc actgactgtc tatgcctggg      240

aaagggtggg caggagatgg ggcagtgcag gaaaagtggc actatgaacc ctgcagccct      300

aggaatgcat ctagacaatt gtactaacct tcttctcttt cctctcctga caggttggtg      360

tacagtagct tccacc                                                      376


<210>  55
<211>  192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  55
cctgcagcag tggatattcc cagaaaactt tttggatgca gttggggatt tcctctttac       60

tggatgtgga caatatcctc ctattattca caggaagcaa tccctcctat aaaagggcct      120

cagcagaagt agtgttcagc tgttcttggc tgacttcaca tcaaagcttc tatactgacc      180

tgagacagag cc                                                          192


