﻿                         序列表

<110>  昆山新蕴达生物科技有限公司

<120>  铁蛋白-ACE-2短肽纳米药物

<130>  MTP20077

<160>  37

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  23
<212>  PRT
<213>  ACE2-P1(Human)

<400>  1
Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala 
1               5                   10                  15      
Glu Asp Leu Phe Tyr Gln Ser 
            20              

<210>  2
<211>  39
<212>  PRT
<213>  ACE2-P2(Human)

<400>  2
Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
1               5                   10                  15      
Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
            20                  25                  30          
Asp Phe Arg Ile Leu Met Cys 
        35                  

<210>  3
<211>  10
<212>  PRT
<213>  ACE2-P3(Human)

<400>  3
Met Thr Gln Gly Phe Trp Glu Asn Ser Met 
1               5                   10  

<210>  4
<211>  18
<212>  PRT
<213>  ACE2-P4(Human)

<400>  4
Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu 
1               5                   10                  15      
Met Cys 
        

<210>  5
<211>  183
<212>  PRT
<213>  HFn-WT(Human)

<400>  5
Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      
Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          
Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              
Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  
Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  
Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      
Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         
Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             
His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 
Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 
Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     
Gly Asp Ser Asp Asn Glu Ser 
            180             

<210>  6
<211>  163
<212>  PRT
<213>  mHFn1(Human)

<400>  6
Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      
Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          
Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              
Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  
Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  
Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      
Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         
Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             
His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 
Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 
Ala Pro Glu 
            

<210>  7
<211>  183
<212>  PRT
<213>  mHFn2(Human)

<400>  7
Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      
Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          
Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              
Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  
Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  
Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp Glu Ser 
                85                  90                  95      
Gly Leu Asn Ala Met Glu Ala Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         
Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             
His Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 
Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 
Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     
Gly Asp Ser Asp Asn Glu Ser 
            180             

<210>  8
<211>  163
<212>  PRT
<213>  mHFn3(Human)

<400>  8
Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      
Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          
Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              
Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  
Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  
Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp Glu Ser 
                85                  90                  95      
Gly Leu Asn Ala Met Glu Ala Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         
Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             
His Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 
Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 
Ala Pro Glu 
            

<210>  9
<211>  221
<212>  PRT
<213>  ACE2-P1-mHFn2(Human)

<400>  9
Met Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
1               5                   10                  15      
Ala Glu Asp Leu Phe Tyr Gln Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          
Gly Ser Gly Gly Gly Gly Ser Thr Thr Ala Ser Thr Ser Gln Val Arg 
        35                  40                  45              
Gln Asn Tyr His Gln Asp Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn 
    50                  55                  60                  
Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe 
65                  70                  75                  80  
Asp Arg Asp Asp Val Ala Leu Lys Asn Phe Ala Lys Tyr Phe Leu His 
                85                  90                  95      
Gln Ser His Glu Glu Arg Glu His Ala Glu Lys Leu Met Lys Leu Gln 
            100                 105                 110         
Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp 
        115                 120                 125             
Glu Asp Asp Trp Glu Ser Gly Leu Asn Ala Met Glu Ala Ala Leu His 
    130                 135                 140                 
Leu Glu Lys Asn Val Asn Gln Ser Leu Leu Glu Leu His Lys Leu Ala 
145                 150                 155                 160 
Thr Asp Lys Asn Asp Pro His Leu Ala Asp Phe Ile Glu Thr His Tyr 
                165                 170                 175     
Leu Asn Glu Gln Val Lys Ala Ile Lys Glu Leu Gly Asp His Val Thr 
            180                 185                 190         
Asn Leu Arg Lys Met Gly Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu 
        195                 200                 205             
Phe Asp Lys His Thr Leu Gly Asp Ser Asp Asn Glu Ser 
    210                 215                 220     

<210>  10
<211>  201
<212>  PRT
<213>  mHFn3-ACE2-P1(Human)

<400>  10
Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      
Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          
Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              
Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  
Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  
Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp Glu Ser 
                85                  90                  95      
Gly Leu Asn Ala Met Glu Ala Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         
Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             
His Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 
Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 
Ala Pro Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His 
            180                 185                 190         
Glu Ala Glu Asp Leu Phe Tyr Gln Ser 
        195                 200     

<210>  11
<211>  206
<212>  PRT
<213>  mHFn2-ACE2-P1(Human)

<400>  11
Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      
Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          
Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Ile Glu Glu 
        35                  40                  45              
Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu Ala Glu Asp Leu 
    50                  55                  60                  
Phe Tyr Gln Ser Asp Val Ala Leu Lys Asn Phe Ala Lys Tyr Phe Leu 
65                  70                  75                  80  
His Gln Ser His Glu Glu Arg Glu His Ala Glu Lys Leu Met Lys Leu 
                85                  90                  95      
Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln Asp Ile Lys Lys Pro 
            100                 105                 110         
Asp Glu Asp Asp Trp Glu Ser Gly Leu Asn Ala Met Glu Ala Ala Leu 
        115                 120                 125             
His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu Glu Leu His Lys Leu 
    130                 135                 140                 
Ala Thr Asp Lys Asn Asp Pro His Leu Ala Asp Phe Ile Glu Thr His 
145                 150                 155                 160 
Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys Glu Leu Gly Asp His Val 
                165                 170                 175     
Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser Gly Leu Ala Glu Tyr 
            180                 185                 190         
Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp Asn Glu Ser 
        195                 200                 205     

<210>  12
<211>  236
<212>  PRT
<213>  ACE2-P2-mHFn2(Human)

<400>  12
Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
1               5                   10                  15      
Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
            20                  25                  30          
Asp Phe Arg Ile Leu Met Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              
Ser Gly Gly Gly Gly Ser Thr Thr Ala Ser Thr Ser Gln Val Arg Gln 
    50                  55                  60                  
Asn Tyr His Gln Asp Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu 
65                  70                  75                  80  
Glu Leu Tyr Ala Ser Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp 
                85                  90                  95      
Arg Asp Asp Val Ala Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln 
            100                 105                 110         
Ser His Glu Glu Arg Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn 
        115                 120                 125             
Gln Arg Gly Gly Arg Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu 
    130                 135                 140                 
Asp Asp Trp Glu Ser Gly Leu Asn Ala Met Glu Ala Ala Leu His Leu 
145                 150                 155                 160 
Glu Lys Asn Val Asn Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr 
                165                 170                 175     
Asp Lys Asn Asp Pro His Leu Ala Asp Phe Ile Glu Thr His Tyr Leu 
            180                 185                 190         
Asn Glu Gln Val Lys Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn 
        195                 200                 205             
Leu Arg Lys Met Gly Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe 
    210                 215                 220                 
Asp Lys His Thr Leu Gly Asp Ser Asp Asn Glu Ser 
225                 230                 235     

<210>  13
<211>  217
<212>  PRT
<213>  mHFn3-ACE2-P2(Human)

<400>  13
Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      
Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          
Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              
Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  
Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  
Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp Glu Ser 
                85                  90                  95      
Gly Leu Asn Ala Met Glu Ala Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         
Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             
His Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 
Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 
Ala Pro Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
            180                 185                 190         
Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
        195                 200                 205             
Lys Gly Asp Phe Arg Ile Leu Met Cys 
    210                 215         

<210>  14
<211>  207
<212>  PRT
<213>  ACE2-P3-mHFn2(Human)

<400>  14
Met Thr Gln Gly Phe Trp Glu Asn Ser Met Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser Thr Thr Ala Ser Thr Ser Gln 
            20                  25                  30          
Val Arg Gln Asn Tyr His Gln Asp Ser Glu Ala Ala Ile Asn Arg Gln 
        35                  40                  45              
Ile Asn Leu Glu Leu Tyr Ala Ser Tyr Val Tyr Leu Ser Met Ser Tyr 
    50                  55                  60                  
Tyr Phe Asp Arg Asp Asp Val Ala Leu Lys Asn Phe Ala Lys Tyr Phe 
65                  70                  75                  80  
Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu Lys Leu Met Lys 
                85                  90                  95      
Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln Asp Ile Lys Lys 
            100                 105                 110         
Pro Asp Glu Asp Asp Trp Glu Ser Gly Leu Asn Ala Met Glu Ala Ala 
        115                 120                 125             
Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu Glu Leu His Lys 
    130                 135                 140                 
Leu Ala Thr Asp Lys Asn Asp Pro His Leu Ala Asp Phe Ile Glu Thr 
145                 150                 155                 160 
His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys Glu Leu Gly Asp His 
                165                 170                 175     
Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser Gly Leu Ala Glu 
            180                 185                 190         
Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp Asn Glu Ser 
        195                 200                 205         

<210>  15
<211>  188
<212>  PRT
<213>  mHFn3-ACE2-P3(Human)

<400>  15
Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      
Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          
Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              
Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  
Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  
Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp Glu Ser 
                85                  90                  95      
Gly Leu Asn Ala Met Glu Ala Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         
Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             
His Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 
Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 
Ala Pro Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Met Thr Gln Gly Phe Trp Glu Asn Ser Met 
            180                 185             

<210>  16
<211>  193
<212>  PRT
<213>  mHFn2-ACE2-P3(Human)

<400>  16
Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      
Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          
Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Met Thr Gln 
        35                  40                  45              
Gly Phe Trp Glu Asn Ser Met Asp Val Ala Leu Lys Asn Phe Ala Lys 
    50                  55                  60                  
Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu His Ala Glu Lys Leu 
65                  70                  75                  80  
Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile Phe Leu Gln Asp Ile 
                85                  90                  95      
Lys Lys Pro Asp Glu Asp Asp Trp Glu Ser Gly Leu Asn Ala Met Glu 
            100                 105                 110         
Ala Ala Leu His Leu Glu Lys Asn Val Asn Gln Ser Leu Leu Glu Leu 
        115                 120                 125             
His Lys Leu Ala Thr Asp Lys Asn Asp Pro His Leu Ala Asp Phe Ile 
    130                 135                 140                 
Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala Ile Lys Glu Leu Gly 
145                 150                 155                 160 
Asp His Val Thr Asn Leu Arg Lys Met Gly Ala Pro Glu Ser Gly Leu 
                165                 170                 175     
Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly Asp Ser Asp Asn Glu 
            180                 185                 190         
Ser 
    

<210>  17
<211>  216
<212>  PRT
<213>  ACE2-P4-mHFn2(Human)

<400>  17
Met Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile 
1               5                   10                  15      
Leu Met Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          
Gly Ser Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln 
        35                  40                  45              
Asp Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala 
    50                  55                  60                  
Ser Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val 
65                  70                  75                  80  
Ala Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu 
                85                  90                  95      
Arg Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly 
            100                 105                 110         
Arg Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp Glu 
        115                 120                 125             
Ser Gly Leu Asn Ala Met Glu Ala Ala Leu His Leu Glu Lys Asn Val 
    130                 135                 140                 
Asn Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp 
145                 150                 155                 160 
Pro His Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val 
                165                 170                 175     
Lys Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met 
            180                 185                 190         
Gly Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr 
        195                 200                 205             
Leu Gly Asp Ser Asp Asn Glu Ser 
    210                 215     

<210>  18
<211>  196
<212>  PRT
<213>  mHFn3-ACE2-P4(Human)

<400>  18
Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      
Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          
Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              
Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  
Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  
Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp Glu Ser 
                85                  90                  95      
Gly Leu Asn Ala Met Glu Ala Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         
Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             
His Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 
Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 
Ala Pro Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg 
            180                 185                 190         
Ile Leu Met Cys 
        195     

<210>  19
<211>  201
<212>  PRT
<213>  mHFn2-ACE2-P4(Human)

<400>  19
Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      
Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          
Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Cys His Pro 
        35                  40                  45              
Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Asp 
    50                  55                  60                  
Val Ala Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu 
65                  70                  75                  80  
Glu Arg Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly 
                85                  90                  95      
Gly Arg Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp 
            100                 105                 110         
Glu Ser Gly Leu Asn Ala Met Glu Ala Ala Leu His Leu Glu Lys Asn 
        115                 120                 125             
Val Asn Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn 
    130                 135                 140                 
Asp Pro His Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln 
145                 150                 155                 160 
Val Lys Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys 
                165                 170                 175     
Met Gly Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His 
            180                 185                 190         
Thr Leu Gly Asp Ser Asp Asn Glu Ser 
        195                 200     

<210>  20
<211>  174
<212>  PRT
<213>  LFn-WT(Human)

<400>  20
Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val 
1               5                   10                  15      
Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser 
            20                  25                  30          
Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser 
        35                  40                  45              
His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg 
    50                  55                  60                  
Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp 
65                  70                  75                  80  
Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met 
                85                  90                  95      
Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp 
            100                 105                 110         
Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe 
        115                 120                 125             
Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met 
    130                 135                 140                 
Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly 
145                 150                 155                 160 
Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
                165                 170                 

<210>  21
<211>  174
<212>  PRT
<213>  mLFn1(Human)

<400>  21
Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val 
1               5                   10                  15      
Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser 
            20                  25                  30          
Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser 
        35                  40                  45              
His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg 
    50                  55                  60                  
Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp 
65                  70                  75                  80  
Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met 
                85                  90                  95      
Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp 
            100                 105                 110         
Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Ala Asp Phe 
        115                 120                 125             
Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met 
    130                 135                 140                 
Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly 
145                 150                 155                 160 
Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
                165                 170                 

<210>  22
<211>  157
<212>  PRT
<213>  mLFn2(Human)

<400>  22
Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      
Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          
Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              
Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  
Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  
Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      
Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         
Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp 
        115                 120                 125             
Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 
Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly 
145                 150                 155         

<210>  23
<211>  157
<212>  PRT
<213>  mLFn3(Human)

<400>  23
Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      
Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          
Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              
Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  
Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  
Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      
Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         
Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Ala Asp 
        115                 120                 125             
Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 
Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly 
145                 150                 155         

<210>  24
<211>  194
<212>  PRT
<213>  mLFn2-ACE2-P1(Human)

<400>  24
Met Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn His Glu 
1               5                   10                  15      
Ala Glu Asp Leu Phe Tyr Gln Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          
Gly Ser Gly Gly Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr 
        35                  40                  45              
Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala 
    50                  55                  60                  
Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val 
65                  70                  75                  80  
Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys 
                85                  90                  95      
Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly 
            100                 105                 110         
Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly 
        115                 120                 125             
Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu 
    130                 135                 140                 
Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp 
145                 150                 155                 160 
Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val 
                165                 170                 175     
Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu 
            180                 185                 190         
Gly Gly 
        

<210>  25
<211>  193
<212>  PRT
<213>  mLFn3-ACE2-P1(Human)

<400>  25
Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      
Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          
Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              
Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  
Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  
Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      
Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         
Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Ala Asp 
        115                 120                 125             
Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 
Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Gly Gly Ser 
145                 150                 155                 160 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Glu Glu Gln Ala Lys 
                165                 170                 175     
Thr Phe Leu Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln 
            180                 185                 190         
Ser 
    

<210>  26
<211>  184
<212>  PRT
<213>  mLFn2-ACE2-P1(Human)

<400>  26
Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      
Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          
Ser Leu Gly Phe Tyr Phe Asp Arg Asp Ile Glu Glu Gln Ala Lys Thr 
        35                  40                  45              
Phe Leu Asp Lys Phe Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser 
    50                  55                  60                  
Asp Val Ala Leu Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg 
65                  70                  75                  80  
Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met 
                85                  90                  95      
Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro 
            100                 105                 110         
Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met 
        115                 120                 125             
Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu 
    130                 135                 140                 
Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His 
145                 150                 155                 160 
Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu 
                165                 170                 175     
Thr Asn Leu His Arg Leu Gly Gly 
            180                 

<210>  27
<211>  209
<212>  PRT
<213>  ACE2-P2-mLFn2(Human)

<400>  27
Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly Asn 
1               5                   10                  15      
Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly 
            20                  25                  30          
Asp Phe Arg Ile Leu Met Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        35                  40                  45              
Ser Gly Gly Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp 
    50                  55                  60                  
Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser 
65                  70                  75                  80  
Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala 
                85                  90                  95      
Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg 
            100                 105                 110         
Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg 
        115                 120                 125             
Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys 
    130                 135                 140                 
Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn 
145                 150                 155                 160 
Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro 
                165                 170                 175     
His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys 
            180                 185                 190         
Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly 
        195                 200                 205             
Gly 
    

<210>  28
<211>  209
<212>  PRT
<213>  mLFn3-ACE2-P2(Human)

<400>  28
Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      
Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          
Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              
Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  
Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  
Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      
Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         
Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Ala Asp 
        115                 120                 125             
Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 
Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Gly Gly Ser 
145                 150                 155                 160 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Thr Gln Gly Phe Trp 
                165                 170                 175     
Glu Asn Ser Met Leu Thr Asp Pro Gly Asn Val Gln Lys Ala Val Cys 
            180                 185                 190         
His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met 
        195                 200                 205             
Cys 
    

<210>  29
<211>  180
<212>  PRT
<213>  ACE2-P3-mLFn2(Human)

<400>  29
Met Thr Gln Gly Phe Trp Glu Asn Ser Met Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gln Ile Arg Gln Asn Tyr 
            20                  25                  30          
Ser Thr Asp Val Glu Ala Ala Val Asn Ser Leu Val Asn Leu Tyr Leu 
        35                  40                  45              
Gln Ala Ser Tyr Thr Tyr Leu Ser Leu Gly Phe Tyr Phe Asp Arg Asp 
    50                  55                  60                  
Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu 
65                  70                  75                  80  
Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg 
                85                  90                  95      
Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu 
            100                 105                 110         
Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys 
        115                 120                 125             
Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
    130                 135                 140                 
Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
145                 150                 155                 160 
Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr Asn Leu His 
                165                 170                 175     
Arg Leu Gly Gly 
            180 

<210>  30
<211>  180
<212>  PRT
<213>  mLFn3-ACE2-P3(Human)

<400>  30
Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      
Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          
Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              
Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  
Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  
Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      
Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         
Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Ala Asp 
        115                 120                 125             
Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 
Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Gly Gly Ser 
145                 150                 155                 160 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Thr Gln Gly Phe Trp 
                165                 170                 175     
Glu Asn Ser Met 
            180 

<210>  31
<211>  167
<212>  PRT
<213>  mLFn2-ACE2-P3(Human)

<400>  31
Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      
Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          
Ser Leu Gly Phe Tyr Phe Asp Arg Asp Met Thr Gln Gly Phe Trp Glu 
        35                  40                  45              
Asn Ser Met Asp Val Ala Leu Glu Gly Val Ser His Phe Phe Arg Glu 
    50                  55                  60                  
Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg Leu Leu Lys Met Gln 
65                  70                  75                  80  
Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp Ile Lys Lys Pro Ala 
                85                  90                  95      
Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met Lys Ala Ala Met Ala 
            100                 105                 110         
Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly 
        115                 120                 125             
Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe 
    130                 135                 140                 
Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met Gly Asp His Leu Thr 
145                 150                 155                 160 
Asn Leu His Arg Leu Gly Gly 
                165         

<210>  32
<211>  189
<212>  PRT
<213>  ACE2-P4-mLFn2(Human)

<400>  32
Met Cys His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile 
1               5                   10                  15      
Leu Met Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          
Gly Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
        35                  40                  45              
Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
    50                  55                  60                  
Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
65                  70                  75                  80  
Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
                85                  90                  95      
Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
            100                 105                 110         
Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
        115                 120                 125             
Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
    130                 135                 140                 
Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp 
145                 150                 155                 160 
Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
                165                 170                 175     
Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly 
            180                 185                 

<210>  33
<211>  188
<212>  PRT
<213>  mLFn3-ACE2-P4(Human)

<400>  33
Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      
Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          
Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              
Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  
Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  
Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      
Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         
Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Ala Asp 
        115                 120                 125             
Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 
Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Gly Gly Ser 
145                 150                 155                 160 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys His Pro Thr Ala Trp 
                165                 170                 175     
Asp Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys 
            180                 185             

<210>  34
<211>  175
<212>  PRT
<213>  mLFn2-ACE2-P4(Human)

<400>  34
Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      
Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          
Ser Leu Gly Phe Tyr Phe Asp Arg Asp Cys His Pro Thr Ala Trp Asp 
        35                  40                  45              
Leu Gly Lys Gly Asp Phe Arg Ile Leu Met Cys Asp Val Ala Leu Glu 
    50                  55                  60                  
Gly Val Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly 
65                  70                  75                  80  
Tyr Glu Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu 
                85                  90                  95      
Phe Gln Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro 
            100                 105                 110         
Asp Ala Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala 
        115                 120                 125             
Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu 
    130                 135                 140                 
Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile 
145                 150                 155                 160 
Lys Lys Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly 
                165                 170                 175 

<210>  35
<211>  663
<212>  DNA
<213>  ACE2-P1-mHFn2(Human)

<400>  35
atgattgaag aacaggccaa aacctttctg gataaattta atcatgaagc cgaagacctg        60
ttttatcagt caggcggcgg tggtagtggc ggcggtggta gtggcggcgg tggctctacc       120
accgcaagta cctcacaggt tcgtcagaat tatcatcagg atagcgaagc cgccattaat       180
cgccagatta atctggaact gtatgccagc tatgtgtatc tgagtatgtc ttattatttt       240
gatcgcgatg atgttgccct gaaaaatttt gccaaatatt ttctgcatca gtctcatgaa       300
gaacgcgaac atgccgaaaa actgatgaaa ttacagaatc agcgtggtgg tcgtattttt       360
ttgcaggata ttaaaaaacc ggatgaagat gattgggaaa gcggcctgaa tgcaatggaa       420
gcagcactgc atttagaaaa aaatgttaat cagagcttac tggaattaca taaactggca       480
accgataaaa atgatccgca tttagcagat tttattgaaa cccattatct gaatgaacag       540
gttaaagcaa ttaaagaact gggcgatcat gtgaccaatc tgcgcaaaat gggtgccccg       600
gaaagtggct tagccgaata tctgtttgat aaacatacct taggtgatag cgataatgaa       660
agt                                                                     663

<210>  36
<211>  618
<212>  DNA
<213>  mHFn2-ACE2-P1(Human)

<400>  36
atgaccaccg cctctacctc acaggtgcgc cagaattatc atcaggatag cgaagcagca        60
attaatcgtc agattaatct ggaactgtat gccagctatg tgtatctgag tatgtcttat       120
tattttgatc gcgatattga agaacaggcc aaaacctttc tggataaatt taatcatgaa       180
gccgaagacc tgttttatca gagcgatgtg gccctgaaaa attttgccaa atattttctg       240
catcagtcac atgaagaacg cgaacatgcc gaaaaactga tgaaattaca gaatcagcgt       300
ggtggtcgca tttttctcca ggatattaaa aaaccggatg aagatgattg ggaaagtggc       360
ctgaatgcta tggaagccgc actgcatctg gaaaaaaatg ttaatcagtc tctgttagaa       420
ctgcataaac tggcaaccga taaaaatgat ccgcatttag cagattttat tgaaacccat       480
tatctgaatg aacaggttaa agcaattaaa gaactgggcg atcatgtgac caatttacgt       540
aaaatgggcg ccccggaaag cggcttagcc gaatatctgt ttgataaaca taccttaggt       600
gatagtgata atgaaagt                                                     618

<210>  37
<211>  708
<212>  DNA
<213>  ACE2-P2-mHFn2(Human)

<400>  37
atgacccagg gcttttggga aaatagtatg ctgaccgatc cgggtaatgt gcagaaagcc        60
gtttgtcatc cgaccgcatg ggatttaggc aaaggcgatt ttcgcattct gatgtgtggc       120
ggcggtggta gtggtggtgg tggctcaggt ggcggcggta gcaccaccgc aagtacctca       180
caggttcgtc agaattatca tcaggatagc gaagcagcca ttaatcgcca gattaatctg       240
gaactgtatg cctcttatgt gtatctgtct atgagctatt attttgatcg tgatgatgtt       300
gccctgaaaa attttgccaa atattttctg catcagtctc atgaagaacg cgaacatgcc       360
gaaaaactga tgaaattaca gaatcagcgc ggcggtcgta tttttttaca ggatattaaa       420
aaaccggatg aagatgattg ggaatcaggc ctgaatgcga tggaagcagc cttacattta       480
gaaaaaaatg ttaatcagtc actgctggaa ctgcataaac tggcaaccga taaaaatgat       540
ccgcatctgg cagattttat tgaaacccat tatctgaatg aacaggttaa agcaattaaa       600
gaactgggtg atcatgttac caatttacgt aaaatgggcg ccccggaaag tggcttagcc       660
gaatatctgt ttgataaaca taccttaggc gatagcgata atgaatct                    708

