                         SEQUENCE LISTING

<110>  Biocytogen PharmaceuticalsBeijingCo., Ltd.
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMALS WITH COMMON LIGHT CHAIN 
       IMMUNOGLOBULIN LOCUS

<130>  1

<150>  PCT/CN2020/094000
<151>  2020-06-02

<150>  PCT/CN2021/085839
<151>  2021-04-07

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV1-39

<400>  1
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtaag       60

gatggagaac actaggaatt tactcagcca gtgtgctcag tactgactgg aacttcaggg      120

aagttctctg ataacatgat taatagtaag aatatttgtt tttatgtttc caatctcagg      180

tgccagatgt gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga      240

cagagtcacc atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca      300

gcagaaacca gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg      360

ggtcccatca aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag      420

tctgcaacct gaagattttg caacttacta ctgtcaacag agttacagta cccctcc         477


<210>  2
<211>  516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV3-11

<400>  2
atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccagg tgaggggaac       60

atgaggtggt tttgcacatt agtgaaaact cttgccacct ctgctcagca agaaatataa      120

ttaaaattca aagtatatca acaattttgg ctctactcaa agacagttgg tttgatcttg      180

attacatgag tgcatttctg ttttatttcc aatttcagat accaccggag aaattgtgtt      240

gacacagtct ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag      300

ggccagtcag agtgttagca gctacttagc ctggtaccaa cagaaacctg gccaggctcc      360

caggctcctc atctatgatg catccaacag ggccactggc atcccagcca ggttcagtgg      420

cagtgggtct gggacagact tcactctcac catcagcagc ctagagcctg aagattttgc      480

agtttattac tgtcagcagc gtagcaactg gcctcc                                516


<210>  3
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKV3-20

<400>  3
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccagg tgaggggaac       60

atgggatggt tttgcatgtc agtgaaaacc ctctcaagtc ctgttacctg gcaactctgc      120

tcagtcaata caataattaa agctcaatat aaagcaataa ttctggctct tctgggaaga      180

caatgggttt gatttagatt acatgggtga cttttctgtt ttatttccaa tctcagatac      240

caccggagaa attgtgttga cgcagtctcc aggcaccctg tctttgtctc caggggaaag      300

agccaccctc tcctgcaggg ccagtcagag tgttagcagc agctacttag cctggtacca      360

gcagaaacct ggccaggctc ccaggctcct catctatggt gcatccagca gggccactgg      420

catcccagac aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag      480

actggagcct gaagattttg cagtgtatta ctgtcagcag tatggtagct cacctcc         537


<210>  4
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKJ1

<400>  4
gtggacgttc ggccaaggga ccaaggtgga aatcaaac                               38


<210>  5
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IGKJ4

<400>  5
gctcactttc ggcggaggga ccaaggtgga gatcaaac                               38


<210>  6
<211>  1189
<212>  DNA
<213>  Mus musculus

<400>  6
gtaagtacac ttttctcatc tttttttatg tgtaagacac aggttttcat gttaggagtt       60

aaagtcagtt cagaaaatct tgagaaaatg gagagggctc attatcagtt gacgtggcat      120

acagtgtcag attttctgtt tatcaagcta gtgagattag gggcaaaaag aggctttagt      180

tgagaggaaa gtaattaata ctatggtcac catccaagag attggatcgg agaataagca      240

tgagtagtta ttgagatctg ggtctgactg caggtagcgt ggtcttctag acgtttaagt      300

gggagatttg gaggggatga ggaatgaagg aacttcagga tagaaaaggg ctgaagtcaa      360

gttcagctcc taaaatggat gtgggagcaa actttgaaga taaactgaat gacccagagg      420

atgaaacagc gcagatcaaa gaggggcctg gagctctgag aagagaagga gactcatccg      480

tgttgagttt ccacaagtac tgtcttgagt tttgcaataa aagtgggata gcagagttga      540

gtgagccgta ggctgagttc tctcttttgt ctcctaagtt tttatgacta caaaaatcag      600

tagtatgtcc tgaaataatc attaagctgt ttgaaagtat gactgcttgc catgtagata      660

ccatggcttg ctgaataatc agaagaggtg tgactcttat tctaaaattt gtcacaaaat      720

gtcaaaatga gagactctgt aggaacgagt ccttgacaga cagctcaagg ggtttttttc      780

ctttgtctca tttctacatg aaagtaaatt tgaaatgatc ttttttatta taagagtaga      840

aatacagttg ggtttgaact atatgtttta atggccacgg ttttgtaaga catttggtcc      900

tttgttttcc cagttattac tcgattgtaa ttttatatcg ccagcaatgg actgaaacgg      960

tccgcaacct cttctttaca actgggtgac ctcgcggctg tgccagccat ttggcgttca     1020

ccctgccgct aagggccatg tgaacccccg cggtagcatc ccttgctccg cgtggaccac     1080

tttcctgagg cacagtgata ggaacagagc cactaatctg aagagaacag agatgtgaca     1140

gactacacta atgtgagaaa aacaaggaaa gggtgactta ttggagatt                 1189


<210>  7
<211>  500
<212>  DNA
<213>  Homo sapiens

<400>  7
gtaagtaatt tttcactatt gtcttctgaa atttgggtct gatggccagt attgactttt       60

agaggcttaa ataggagttt ggtaaagatt ggtaaatgag ggcatttaag atttgccatg      120

ggttgcaaaa gttaaactca gcttcaaaaa tggatttgga gaaaaaaaga ttaaattgct      180

ctaaactgaa tgacacaaag taaaaaaaaa aagtgtaact aaaaaggaac ccttgtattt      240

ctaaggagca aaagtaaatt tatttttgtt cactcttgcc aaatattgta ttggttgttg      300

ctgattatgc atgatacaga aaagtggaaa aatacatttt ttagtctttc tcccttttgt      360

ttgataaatt attttgtcag acaacaataa aaatcaatag cacgccctaa gaaaaatcag      420

ggaaaagtga agtgtaccta tttgctatgt agaagaggca gcttacttga aaatcagcag      480

caatgttgtt tttagagtct                                                  500


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
tcacacacta cagcttccac cacaa                                             25


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
tgggcgcgcc agactctaaa                                                   20


<210>  10
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
tgggtctgat ggccagtatt gact                                              24


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
ggcctggaaa actcagctat ccttt                                             25


<210>  12
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
gccaaggaat ttaaaagggg attgaaagca a                                      31


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  13
agggagggaa tggaatgagg gtgat                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
ccatgtgacc cattcgagtg tcctg                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  15
cttaccattt gcggtgcctg gtttc                                             25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  16
tcacacacta cagcttccac cacaa                                             25


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  17
tgggcgcgcc agactctaaa                                                   20


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
tgggtctgat ggccagtatt gact                                              24


<210>  19
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  19
ggcctggaaa actcagctat ccttt                                             25


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  20
tcacacacta cagcttccac cacaa                                             25


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  21
tgggcgcgcc agactctaaa                                                   20


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  22
tgggtctgat ggccagtatt gact                                              24


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  23
ggcctggaaa actcagctat ccttt                                             25


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  24
agacttgatg gtgtggagtg gggta                                             25


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  25
tgggccctgt actttgcttg aacat                                             25


<210>  26
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  26
tgatgggtca accatgttcc tgtgg                                             25


<210>  27
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  27
tcagccattg cttctgcttt ctcct                                             25


<210>  28
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  28
gaaaagtggc tttgatggtg caggg                                             25


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  29
tgcccatttt tctgcccttg ggtat                                             25


<210>  30
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  30
aggcattcct tatgccagtc agcat                                             25


<210>  31
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  31
tttcccatgt cctgctgctt tcctt                                             25


<210>  32
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  32
catttaggga gctgactggg cacaa                                             25


<210>  33
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  33
tctgggtcct aactgagcag ctctt                                             25


<210>  34
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  34
ctaacactca ttcctgttga agctcttgac                                        30


<210>  35
<211>  3012
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rearranged human IGKV1-39+J4 nucleic acid sequence

<400>  35
gcaggcagca tatttataat gcacagtaaa cactaggagg aaacaaggca gtgagagagg       60

aaagagagca gcgataccga aaatgtcctc agcgagaagc taccacagag gatgaatgga      120

gatcaagccc acgtggaaac atgggaaaat gtctcagtat ttttccacct aagaagggag      180

ggagatgggg tatgtataca cctccctgtc ctcactgatt gagggctttc cgagaggatg      240

ctcattccag gtgctgtgat aggccatgtg tacaggcagg gctgccttct ccagcttcag      300

atagagcagt gaggaaaaga tatggccatg gggggtcagc agaagtacag caaagggaaa      360

agggaaaggg tagcaagagt gacaactata ttcacccccc ccacacacac acacacacac      420

acgaaattgt gtattgcaat ccagaactgc ttctctctga acctaaatct tagcaagcag      480

tttaccagta actgcccttg aaattcaggc ccctggaaag gagcaggggg ttgtgtacag      540

gctataccac agcagtctgc ccacccttag tgatgcatga gtaatgctcc ctggactccc      600

caggttctag tcttctcatg tcgatgtagt tgattccact tcccttgctg cacaaccagg      660

ctgggatgcc tgggcagagg cagacatgtg aggtataggg gttcaaatct gtttccaagt      720

tttatccagc ttcaaagcat ttctccgtgt acatgagcgg tggcttgaca ggagatggag      780

actctctttc ctggatgtga ggcaaggagg caggcgtctg agtcaggatg atgtccctac      840

tcactgctaa agagaaaagt ggctttgatg gtgcagggca gggaaatgca ctgagtggtc      900

gccaccctca cagaagagaa agtgttcact gacctggcct ttccccaggg cctctccctc      960

ccattgcttt ccagaaagcc atgatttttg agagccacac ctgaacactc acaaacatta     1020

tggtgggaaa agcagatcag agcattaggc aagttgcatt accttggcct tcttcctttg     1080

gagacaattg atgtggggtt ctagattgac ccagagtttc aagtttatcc tgattcaggc     1140

ttcaacagct ggaggaagaa acagagatgt tttttgaagt aaacagatct agcattacta     1200

atcaaccctt catactgatg acctatggga aataataccc aagggcagaa aaatgggcag     1260

aataagggga gccccaaacc aagacgaagc tgctgcccat tgagaccctg ggtattacag     1320

agacctatag ctctggataa tggaagatct atgagtggca caggcgctga ggaatcacag     1380

catcattatc gtgcatctgc agggaattgc ttgtaaatat actggtaatt acaaatgttt     1440

aaggtcacta caaatacttt ggagtgtatt aaatatgctt ctgataaaga ctgtttttct     1500

cacatgaaac aatgggaacc atgtgacaat cacagaggtg ttgttactat agcaaaaggg     1560

attgttactc tccacatccc tttaagtaac ttgaaggcct gatagaccca ccctctaaga     1620

cttcattaga cattccctac gaatggttat actctcctgt atactcccaa tacaactcta     1680

aaatatatta ttccatatag tccttaggtt tgtattaaag tttgactttt ttccttcaaa     1740

atatctcttg tcacaacagc ggctctagag agaaatacat tccctccagg caaatctatg     1800

ctgcgctggt ctgacctggg accctgggga cattgcccct gtgctgagtt actaagatga     1860

gccagccctg cagctgtgct cagcctgccc catgccctgc tgattgattt gcatgttcca     1920

gagcacagcc ccctgccctg aagacttttt tatgggctgg tcgcaccctg tgcaggagtc     1980

agtctcagtc aggacacagc atggacatga gggtccccgc tcagctcctg gggctcctgc     2040

tactctggct ccgaggtaag gatggagaac actaggaatt tactcagcca gtgtgctcag     2100

tactgactgg aacttcaggg aagttctctg ataacatgat taatagtaag aatatttgtt     2160

tttatgtttc caatctcagg tgccagatgt gacatccaga tgacccagtc tccatcctcc     2220

ctgtctgcat ctgtaggaga cagagtcacc atcacttgcc gggcaagtca gagcattagc     2280

agctatttaa attggtatca gcagaaacca gggaaagccc ctaagctcct gatctatgct     2340

gcatccagtt tgcaaagtgg ggtcccatca aggttcagtg gcagtggatc tgggacagat     2400

ttcactctca ccatcagcag tctgcaacct gaagattttg caacttacta ctgtcaacag     2460

agttacagta cccctctcac tttcggcgga gggaccaagg tggagatcaa acgtaagtaa     2520

tttttcacta ttgtcttctg aaatttgggt ctgatggcca gtattgactt ttagaggctt     2580

aaataggagt ttggtaaaga ttggtaaatg agggcattta agatttgcca tgggttgcaa     2640

aagttaaact cagcttcaaa aatggatttg gagaaaaaaa gattaaattg ctctaaactg     2700

aatgacacaa agtaaaaaaa aaaagtgtaa ctaaaaagga acccttgtat ttctaaggag     2760

caaaagtaaa tttatttttg ttcactcttg ccaaatattg tattggttgt tgctgattat     2820

gcatgataca gaaaagtgga aaaatacatt ttttagtctt tctccctttt gtttgataaa     2880

ttattttgtc agacaacaat aaaaatcaat agcacgccct aagaaaaatc agggaaaagt     2940

gaagtgtacc tatttgctat gtagaagagg cagcttactt gaaaatcagc agcaatgttg     3000

tttttagagt ct                                                         3012


<210>  36
<211>  3051
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rearranged human IGKV3-11+J1 nucleic acid sequence

<400>  36
caggagtgag cctggtttga tgcctctctc cccaacacga tagaagtgtg gcacaaatct       60

ttgaaaaatt cagtttcccc gtggcaacaa caactacctg ggactgaaaa cttcttccct      120

cgctctagtc ctttcttcta cacccacttc cacctcatct gtgactcata caatacttgt      180

caggaaagat tctggaaaaa gcaaagagac ttccttagag gtgtcagaga ttcctgtacc      240

agcatctgtc catctctaga gggggttgtg agtatgagga agagcagagc ttgtcaatct      300

tctacttgct ttcactccca ctgtatttcc taacaacagc aaccagagca acagccatat      360

catcacagga cgaacctctc ctacttccaa ggcttttatt tcagtaaatc tgctctacct      420

ctatctcagg cagctagaag ttttgatact catacaaata ctactgcagc tttctgttca      480

taattggaaa agtagacaag actcagtgta atgcaggcat tccttatgcc agtcagcatt      540

cagtttttgg atcatcattg cacacatata cccaccatgt gtctaatata tatgtaaaaa      600

tccatgaagc aagagtcata atagctagca tttgatattg tattgtattt tcctcttata      660

tcatcttctc cttttcgtcc ttaaaaaaaa tctgttcaag tcagtctaaa ttaattattg      720

gatgataagt agataaaatc ttttatttga taacacattg acccaatgaa tatgtttctt      780

tgcaagacat agtcctcact tccaagataa caagcctgac aaaattatac tggagcaagt      840

ccacaagtaa tgatggtagc ttttccttat tgtcagtcct ggggcaaaaa taagacaaaa      900

gataacaagg tagactaaag attatgtaag aaagaaggaa agcagcagga catgggaaac      960

tttcatagga taacattttg ataatggatg atgagaatta atgcgttaga cagagatggg     1020

cgggaatgat tgaaggtctg agcattttag cacagattaa gaccaaatca ttaggatttt     1080

aagagttgtg tacagttagt gaagaaaaag ccctagaatt taatttgact gttgataaaa     1140

cattcttgga ttagattgaa gactcttttc tgtgccaagt aagtatattt atgataatga     1200

tgatgactgt agtgctaaat atttaatcaa taaaaacaaa aataattgcc gcatacataa     1260

tgtcctgagt actactgtaa atgttttatc ttattttctt taaactgtct acagcactgt     1320

aaggtaggca ccagtattgt cacagttaca cagatatgga aactgagaca cagggaagtt     1380

aagttagttg gtcaatttca agcaatcggc aagccatgga gcatctatgt cagggctgcc     1440

aggacatgtg actgtaaaca gaagttttaa ctttttaact caaagagggt atgtgtctgg     1500

gttaatggaa agtttcagga ccctcagaaa acattactaa caagcaaatg aaaggtgtat     1560

ctggaagatt aagttctaac agactcctca tttccatcga tccaataatg cacttaggga     1620

gatgactggg catattgagg ataggaagag agaaatgaaa acacagcctt ttatattgtt     1680

cttaacaggc ttgtgccaaa catcatctgg gtgaatttag gtgattgagg agaagaaaga     1740

cataggaatg aaattctctg agcacaaggg agaagttcta cactcagact gagccaacag     1800

acttttctgg cctgacaacc agggtggcgc aggatgctca gtgcagagag gaagaagcag     1860

gtggtctctg cagctggaag ctcagctccc acccagctgc tttgcatgtc cctcccagct     1920

gccctacctt ccagagccca tatcaatgcc tgtgtcagag ccctggggag gaactgctca     1980

gttaggaccc agagggaacc atggaagccc cagctcagct tctcttcctc ctgctactct     2040

ggctcccagg tgaggggaac atgaggtggt tttgcacatt agtgaaaact cttgccacct     2100

ctgctcagca agaaatataa ttaaaattca aagtatatca acaattttgg ctctactcaa     2160

agacagttgg tttgatcttg attacatgag tgcatttctg ttttatttcc aatttcagat     2220

accaccggag aaattgtgtt gacacagtct ccagccaccc tgtctttgtc tccaggggaa     2280

agagccaccc tctcctgcag ggccagtcag agtgttagca gctacttagc ctggtaccaa     2340

cagaaacctg gccaggctcc caggctcctc atctatgatg catccaacag ggccactggc     2400

atcccagcca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcagc     2460

ctagagcctg aagattttgc agtttattac tgtcagcagc gtagcaactg gcctccgacg     2520

ttcggccaag ggaccaaggt ggaaatcaaa cgtaagtaat ttttcactat tgtcttctga     2580

aatttgggtc tgatggccag tattgacttt tagaggctta aataggagtt tggtaaagat     2640

tggtaaatga gggcatttaa gatttgccat gggttgcaaa agttaaactc agcttcaaaa     2700

atggatttgg agaaaaaaag attaaattgc tctaaactga atgacacaaa gtaaaaaaaa     2760

aaagtgtaac taaaaaggaa cccttgtatt tctaaggagc aaaagtaaat ttatttttgt     2820

tcactcttgc caaatattgt attggttgtt gctgattatg catgatacag aaaagtggaa     2880

aaatacattt tttagtcttt ctcccttttg tttgataaat tattttgtca gacaacaata     2940

aaaatcaata gcacgcccta agaaaaatca gggaaaagtg aagtgtacct atttgctatg     3000

tagaagaggc agcttacttg aaaatcagca gcaatgttgt ttttagagtc t              3051


<210>  37
<211>  3072
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rearranged human IGK V3-20+J1 nucleic acid sequence

<400>  37
agccagtgga tgactatttt ctttcctgag actgataatg gtcattccac ccaatggtcc       60

aaactacatg cagtggtaat ggtcatgcag gcctttctgc cacctcttgc tatattttta      120

ccaactcatg ggccactgcc aacagtctag ctatctgatc aggaaaatag caaccgagtg      180

actggactat taaagcatcc cctctgtgga gaaaaggact atggcaacag cttgccacct      240

ataagagaca aatatgtcac tcagctggat gctgggtcta ccatgaccac ccttgagatg      300

aacttatgcc atgtttttgg atgcccactg agactttgct ttgaccaagg aaagttcttt      360

actgcccaaa tgacgtcaat ggacacactc tcatgggaca tgatggattt tccatacacc      420

ttgttatcca aaggccaatg gatctattta atgctagaac agctgactca cacggcaact      480

gaagagtgta catcagggca acctgctagt agagtggtac cccatctgac tacagcaatt      540

ggacattaaa cactgcactg cagagcaagg gaaagacggc acggaggtgc aggttgaaaa      600

acactgagtt gagtgaggaa gaagttgggc aaggccagtt tcctgataga gctgccactg      660

tgaaatccca aactcagtgt ttccaatcat ttttttcctt ttatagtgat gttcttgggg      720

gtgttgcagt ttaggccacc atgataaccc agacaggcct cctaactcta attggatgga      780

atgattcccc tgggtgcctt ctatgggttc cacaggatca agaaatatca gggtgttaat      840

ttccttctgc tggtaggagg gtcatctgat tcctccatta gggtggatga cgttatcaga      900

catgtcaatt ttctacagta cttgacctgc cttctagaac tggacaaccg agggtgaaag      960

gactggatca agcaacaatg gcaatgggtg cccaaagagg tagtagtctc agaacaggga     1020

gagacagact gagtccctcc actaactcag cccaacacct gtggatgagt aggggatgcc     1080

tgagatcctg gggtggatgg gaggtggggc actgatctgt caatctgctt tttcttcaag     1140

gatcaggcag cagagaccca gaagcttcat gtctttgtaa ggctcttcca agccaacaca     1200

gataatttga caaaacactg tatctgcatc ccagacctca ccctgtcaca gactgaagtg     1260

gttgtttcat cctactaagg gtaaactata ccagctatac agaataaaaa gactggatag     1320

tttagaggat cacccaagaa atagttcttt gcctgcatgg acaaaaccat cttctgtctt     1380

tagggaaatg gtatcactac cctgaggatt tggagcccag gtctcactta tctgtgcagt     1440

tgtgaaagtc ctcacaccca cagtgctgag gttaattgaa tgttactctt ttaatttctg     1500

caaagaatga gacagcttct ggaccctcag gaaagatcac taacaagtaa atacaagtat     1560

atccggaaga taaagttgta atagactctt cctttcaacc tgatccatca tgcatttagg     1620

gagctgactg ggcacaagtt ggagcagaaa gagaaaaatg aaaccacagc cttctatttt     1680

gtttctaaca gacttgtacc aaacattctg tggctcaatc taggtgatgg tgagacaaga     1740

ggacacaggg gttaaattct gtggccgcag gggagaagtt ctaccctcag actgagccaa     1800

cggccttttc tggcctgatc acctgggcat gggctgctga gagcagaaag gggaggcaga     1860

ttgtctctgc agctgcaagc ccagcacccg ccccagctgc tttgcatgtc cctcccagcc     1920

gccctgcagt ccagagccca tatcaatgcc tgggtcagag ctctggagaa gagctgctca     1980

gttaggaccc agagggaacc atggaaaccc cagcgcagct tctcttcctc ctgctactct     2040

ggctcccagg tgaggggaac atgggatggt tttgcatgtc agtgaaaacc ctctcaagtc     2100

ctgttacctg gcaactctgc tcagtcaata caataattaa agctcaatat aaagcaataa     2160

ttctggctct tctgggaaga caatgggttt gatttagatt acatgggtga cttttctgtt     2220

ttatttccaa tctcagatac caccggagaa attgtgttga cgcagtctcc aggcaccctg     2280

tctttgtctc caggggaaag agccaccctc tcctgcaggg ccagtcagag tgttagcagc     2340

agctacttag cctggtacca gcagaaacct ggccaggctc ccaggctcct catctatggt     2400

gcatccagca gggccactgg catcccagac aggttcagtg gcagtgggtc tgggacagac     2460

ttcactctca ccatcagcag actggagcct gaagattttg cagtgtatta ctgtcagcag     2520

tatggtagct caccttggac gttcggccaa gggaccaagg tggaaatcaa acgtaagtaa     2580

tttttcacta ttgtcttctg aaatttgggt ctgatggcca gtattgactt ttagaggctt     2640

aaataggagt ttggtaaaga ttggtaaatg agggcattta agatttgcca tgggttgcaa     2700

aagttaaact cagcttcaaa aatggatttg gagaaaaaaa gattaaattg ctctaaactg     2760

aatgacacaa agtaaaaaaa aaaagtgtaa ctaaaaagga acccttgtat ttctaaggag     2820

caaaagtaaa tttatttttg ttcactcttg ccaaatattg tattggttgt tgctgattat     2880

gcatgataca gaaaagtgga aaaatacatt ttttagtctt tctccctttt gtttgataaa     2940

ttattttgtc agacaacaat aaaaatcaat agcacgccct aagaaaaatc agggaaaagt     3000

gaagtgtacc tatttgctat gtagaagagg cagcttactt gaaaatcagc agcaatgttg     3060

tttttagagt ct                                                         3072


<210>  38
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  common light chain VL encoded by human IGKV1-39/IGKJ4

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  39
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  common light chain VL encoded by human IGKV3-11/IGKJ1

<400>  39

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  40
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  common light chain VL encoded by human IGKV3-20/IGKJ1

<400>  40

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  41
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  41

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


