80


SEQUENCE LISTING


<110>  Selvax Pty Ltd

<120>  Agonist CD40 Antibodies

<130>  288168

<160>  22

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  1
Gly Tyr Ser Ile Thr Thr Asn Tyr Tyr Trp Asn 1               5                   
10


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  2

Tyr Ile Arg Tyr Asp Gly Thr Thr Tyr Tyr Ala Pro Ser Leu Lys Gly 1               
5                   10                  15


<210>  3
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>

81


<223>  CDRH3

<400>  3

Leu Asp Tyr 1


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  4
Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Phe Leu Asn 1               
5                   10                  15


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  5

Arg Val Ser Asn Arg Phe Ser 1               5


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  6

Leu Gln Val Thr His Val Pro Tyr Thr

82


1               5


<210>  7
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable Region Sequence

<400>  7
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1               
5                   10                  15
Ser Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Thr Thr Asn 20              
    25                  30
Tyr Tyr Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35              
    40                  45
Val Gly Tyr Ile Arg Tyr Asp Gly Thr Thr Tyr Tyr Ala Pro Ser Leu 50              
    55                  60
Lys Gly Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 65              
    70                  75                  80
Leu Gln Leu Thr Ser Val Thr Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 85              
    90                  95
Ala Arg Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 100             
    105                 110


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>

83

<223>  Light Chain Variable Region Sequence

<400>  8
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Leu Gly 1               
5                   10                  15
Asp Arg Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 20              
    25                  30
Asn Gly Asn Thr Phe Leu Asn Trp Phe Gln Gln Lys Pro Gly Gln Ser 35              
    40                  45
Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50              
    55                  60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65              
    70                  75                  80
Ser Arg Val Glu Ala Glu Asp Glu Gly Val Tyr Phe Cys Leu Gln Val 85              
    90                  95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100             
    105                 110


Arg



<210>  9
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Variable Region Nucleotide Sequence

<400>  9
caggtgcaac tgcagcagag cggccccggg ctggtgaagc ctagccagtc actgtccctc       60

84
acctgcgccg ttagcggcta tagcattacc accaactact actggaattg gatccggcag      120 
gcccccggta agggcctgga gtgggtcggg tacatccggt atgacggcac aacctactat      180 
gccccctctt tgaaaggcag attcagtatc acccgggaca ctagcaagaa ccaattcttt      240 
ctgcagctga cctctgtgac tccagaggac acagctactt actactgcgc acggcttgat      300 
tattggggac agggaacgct ggtgacagtc tcgagt                                336

<210>  10
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain Variable Region Nucleotide Sequence

<400>  10
gacatcgtga tgacccagag ccccctgagc ctgtcagtta gcctggggga tagggccagc       60
atcagttgcc ggtcttcaca aagtctggaa aacagcaacg gcaatacctt tcttaactgg      120
ttccagcaga agcctggcca gtctccccag ctgctgattt acagagtgtc caatcggttt      180
tccggcgtgc ccgaccggtt ctccgggagc ggctctggta ccgactttac actcaaaatc      240
agccgcgtcg aggccgagga tgaaggcgtg tacttctgct tgcaggtgac ccacgtgcca      300
tatactttcg gaggaggcac caagctggag atcaagcgt                             339


<210>  11
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  11
Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 1               
5                   10                  15
Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 20              
    25                  30

85
Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 35              
    40                  45
Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 50              
    55                  60
Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 65              
    70                  75                  80
Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 85              
    90                  95
Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 100             
    105                 110
Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 115             
    120                 125
Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 130             
    135                 140
Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 145             
    150                 155                 160
Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 165             
    170                 175
Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 180             
    185                 190
Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 195             
    200                 205
Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 210             
    215                 220

86



Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 225             
    230                 235                 240
Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 245             
    250                 255
Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 260             
    265                 270


Val Gln Glu Arg Gln 275


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polyhistidine Tag

<400>  12

His His His His His His 1               5


<210>  13
<211>  1417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Nucleotide Sequence

<400>  13
aagcttgcca ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60

gataccaccg gacaggtgca actgcagcag agcggccccg ggctggtgaa gcctagccag      120

tcactgtccc tcacctgcgc cgttagcggc tatagcatta ccaccaacta ctactggaat      180

87
tggatccggc aggcccccgg taagggcctg gagtgggtcg ggtacatccg gtatgacggc      240 
acaacctact atgccccctc tttgaaaggc agattcagta tcacccggga cactagcaag      300 
aaccaattct ttctgcagct gacctctgtg actccagagg acacagctac ttactactgc      360 
gcacggcttg attattgggg acagggaacg ctggtgacag tctcgagtgc tagcaccaag      420 
ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      480 
ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540 
gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      600 
ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      660 
gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      720 
aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      780 
ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      840 
gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      900 
gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      960 
gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1020 
aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1080 
cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1140 
caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1200 
gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1260 
ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1320 
gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1380 
tccctgtctc cgggtaaatg agtcctagct gtctaga                              1417

<210>  14
<211>  741
<212>  DNA
<213>  Artificial Sequence

88



<220>
<223>  Light Chain Nucleotide Sequence

<400>  14
aagcttgcca ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60 
gataccaccg gtgacatcgt gatgacccag agccccctga gcctgtcagt tagcctgggg      120 
gatagggcca gcatcagttg ccggtcttca caaagtctgg aaaacagcaa cggcaatacc      180 
tttcttaact ggttccagca gaagcctggc cagtctcccc agctgctgat ttacagagtg      240 
tccaatcggt tttccggcgt gcccgaccgg ttctccggga gcggctctgg taccgacttt      300 
acactcaaaa tcagccgcgt cgaggccgag gatgaaggcg tgtacttctg cttgcaggtg      360 
acccacgtgc catatacttt cggaggaggc accaagctgg agatcaagcg tacggtagcg      420 
gccccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct      480 
gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat      540 
aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag caaggacagc      600 
acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaagtc      660 
tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg      720 
ggagagtgtt agtaatctag a                                                741

<210>  15
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Selvax01HC Nucelotide Sequence

<400>  15
aagcttgcca ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60
gataccaccg gacaggtgca actgcagcag agcggccccg ggctggtgaa gcctagccag      120
tcactgtccc tcacctgcgc cgttagcggc tatagcatta ccaccaacta ctactggaat      180

89
tggatccggc aggcccccgg taagggcctg gagtgggtcg ggtacatccg gtatgacggc      240 
acaacctact atgccccctc tttgaaaggc agattcagta tcacccggga cactagcaag      300 
aaccaattct ttctgcagct gacctctgtg actccagagg acacagctac ttactactgc      360 
gcacggcttg attattgggg acagggaacg ctggtgacag tctcgagtgc tagcaccaag      420 
ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      480 
ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      540 
gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      600 
ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      660 
gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac      720 
aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      780 
ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      840 
gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      900 
gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      960 
gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1020 
aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1080 
cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1140 
caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1200 
gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1260 
ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1320 
gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1380 
tccctgtctc cgggtaaatg ataatctaga                                      1410

<210>  16
<211>  462
<212>  PRT
<213>  Artificial Sequence

90



<220>
<223>  Selvax01HC amino acid sequence

<400>  16
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1               
5                   10                  15
Asp Thr Thr Gly Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val 20              
    25                  30
Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser 35              
    40                  45
Ile Thr Thr Asn Tyr Tyr Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys 50              
    55                  60
Gly Leu Glu Trp Val Gly Tyr Ile Arg Tyr Asp Gly Thr Thr Tyr Tyr 65              
    70                  75                  80
Ala Pro Ser Leu Lys Gly Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys 85              
    90                  95
Asn Gln Phe Phe Leu Gln Leu Thr Ser Val Thr Pro Glu Asp Thr Ala 100             
    105                 110
Thr Tyr Tyr Cys Ala Arg Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 115             
    120                 125
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 130             
    135                 140
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 145             
    150                 155                 160
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly

91
165                 170                 175
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 180             
    185                 190
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 195             
    200                 205
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 210             
    215                 220
Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 225             
    230                 235                 240
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 245             
    250                 255
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 260             
    265                 270
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 275             
    280                 285
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 290             
    295                 300
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 305             
    310                 315                 320
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 325             
    330                 335
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 340             
    345                 350

92
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 355             
    360                 365
Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 370             
    375                 380
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 385             
    390                 395                 400
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 405             
    410                 415
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 420             
    425                 430
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 435             
    440                 445
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 450                 455 
                460


<210>  17
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Selvax01LC Nucelotide Sequence

<400>  17
aagcttgcca ccatggaaac cccagcgcag cttctcttcc tcctgctact ctggctccca       60
gataccaccg gtgacatcgt gatgacccag agccccctga gcctgtcagt tagcctgggg      120
gatagggcca gcatcagttg ccggtcttca caaagtctgg aaaacagcaa cggcaatacc      180
tttcttaact ggttccagca gaagcctggc cagtctcccc agctgctgat ttacagagtg      240
tccaatcggt tttccggcgt gcccgaccgg ttctccggga gcggctctgg taccgacttt      300

93
acactcaaaa tcagccgcgt cgaggccgag gatgaaggcg tgtacttctg cttgcaggtg      360 
acccacgtgc catatacttt cggaggaggc accaagctgg agatcaagcg tacggtagcg      420 
gccccatctg tcttcatctt cccgccatct gatgagcagt tgaaatctgg aactgcctct      480 
gttgtgtgcc tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat      540 
aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag caaggacagc      600 
acctacagcc tcagcagcac cctgacgctg agcaaagcag actacgagaa acacaaagtc      660 
tacgcctgcg aagtcaccca tcagggcctg agctcgcccg tcacaaagag cttcaacagg      720 
ggagagtgtt agtaatctag a                                                741

<210>  18
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Selvax01LC Amino Acid Sequence

<400>  18
Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 1               
5                   10                  15
Asp Thr Thr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser 20              
    25                  30
Val Ser Leu Gly Asp Arg Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 35              
    40                  45
Leu Glu Asn Ser Asn Gly Asn Thr Phe Leu Asn Trp Phe Gln Gln Lys 50              
    55                  60
Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe 65              
    70                  75                  80

94
Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 85              
    90                  95
Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Glu Gly Val Tyr Phe 100             
    105                 110
Cys Leu Gln Val Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys 115             
    120                 125
Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 130             
    135                 140
Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 145             
    150                 155                 160
Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 165             
    170                 175
Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 180             
    185                 190
Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 195             
    200                 205
Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 210             
    215                 220
Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 225                 
230                 235


<210>  19
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain Amino Acid Sequence

95



<400>  19
Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 1               
5                   10                  15
Ser Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Thr Thr Asn 20              
    25                  30
Tyr Tyr Trp Asn Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35              
    40                  45
Val Gly Tyr Ile Arg Tyr Asp Gly Thr Thr Tyr Tyr Ala Pro Ser Leu 50              
    55                  60
Lys Gly Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 65              
    70                  75                  80
Leu Gln Leu Thr Ser Val Thr Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 85              
    90                  95
Ala Arg Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 100             
    105                 110
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 115             
    120                 125
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 130             
    135                 140
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 145             
    150                 155                 160
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 165             
    170                 175

96
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 180             
    185                 190
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 195             
    200                 205
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 210             
    215                 220
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 225             
    230                 235                 240
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 245             
    250                 255
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 260             
    265                 270
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 275             
    280                 285
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 290             
    295                 300
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 305             
    310                 315                 320
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 325             
    330                 335
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 340             
    345                 350
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 355             
    360                 365

97
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 370             
    375                 380
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 385             
    390                 395                 400
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 405             
    410                 415
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 420             
    425                 430
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435                 440


<210>  20
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain Amino Acid Sequence

<400>  20
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Ser Leu Gly 1               
5                   10                  15
Asp Arg Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 20              
    25                  30
Asn Gly Asn Thr Phe Leu Asn Trp Phe Gln Gln Lys Pro Gly Gln Ser 35              
    40                  45
Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 50              
    55                  60

98
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65              
    70                  75                  80
Ser Arg Val Glu Ala Glu Asp Glu Gly Val Tyr Phe Cys Leu Gln Val 85              
    90                  95
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100             
    105                 110
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 115             
    120                 125
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 130             
    135                 140
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 145             
    150                 155                 160
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 165             
    170                 175
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180             
    185                 190
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195             
    200                 205
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210                 215


<210>  21
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  20ACGJQC_Selvax01HC nucleotide sequence

99


<400>  21
aagcttgcca ccatggaaac ccctgctcag ctgctgtttc tgctgctgct gtggctgcct       60 
gatacaacag gacaggtcca gctccagcag tctggccctg gacttgtgaa gcctagccag      120 
agcctgtctc tgacatgtgc cgtgtctggc tacagcatca ccaccaacta ctactggaac      180 
tggatccggc aggcccctgg caaaggactg gaatgggtcg gatatatcag atacgacggc      240 
accacctact acgcccctag cctgaagggc agattctcca tcaccagaga caccagcaag      300 
aaccagttct tcctgcagct gaccagcgtg acccctgagg ataccgccac ctattactgc      360 
gccagactgg attattgggg ccagggcaca ctggtcacag tgtctagcgc ctctacaaag      420 
ggccctagcg ttttcccact ggctcctagc agcaagagca catctggtgg aacagccgct      480 
ctgggctgcc tggtcaagga ttactttcct gagcctgtga ccgtgtcctg gaattctggt      540 
gctctgacaa gcggcgtgca cacctttcca gccgtgctgc aaagcagcgg cctgtactct      600 
ctgtctagcg tcgtgacagt gcctagcagc tctctgggca cccagaccta catctgcaac      660 
gtgaaccaca agcctagcaa caccaaggtg gacaagaagg tggaacccaa gagctgcgac      720 
aagacccaca cctgtcctcc atgtcctgct ccagaactgc tcggcggacc ctccgttttc      780 
ctgtttccac ctaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgc      840 
gtggtggtgg atgtgtccca cgaggatccc gaagtgaagt tcaattggta cgtggacggc      900 
gtggaagtgc acaacgccaa gaccaagcct agagaggaac agtacaacag cacctacaga      960 
gtggtgtccg tgctgacagt gctgcaccag gactggctga acggcaaaga gtacaagtgc     1020 
aaggtgtcca acaaggccct gcctgctcct atcgagaaaa ccatcagcaa ggccaagggc     1080 
cagccaagag aaccccaggt ttacaccctg cctccaagcc gggaagagat gaccaagaat     1140 
caggtgtccc tgacctgcct cgtgaagggc ttctaccctt ccgatatcgc cgtggaatgg     1200 
gagagcaatg gccagcctga gaacaactac aagacaaccc ctcctgtgct ggacagcgac     1260 
ggctcattct tcctgtacag caagctgacc gtggacaagt ctaggtggca gcagggcaac     1320 
gtgttcagct gttctgtgat gcacgaggcc ctgcacaacc actacaccca gaaatctctg     1380

100
agtctgagcc ccggcaagtg atgatctaga                                      1410


<210>  22
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  20ACGJRC_Selvax01LC nucleotide sequence

<400>  22
aagcttgcca ccatggaaac ccctgctcag ctgctgtttc tgctgctgct gtggctgcct       60
gataccaccg gcgatatcgt gatgacacag agccctctga gcctgtccgt gtctctgggc      120
gatagagcca gcatcagctg tagaagcagc cagagcctgg aaaacagcaa cggcaacacc      180
ttcctgaact ggttccagca gaagcccgga cagtctcccc agctgctgat ctacagagtg      240
tccaacagat tcagcggcgt gcccgataga ttttctggca gcggctctgg caccgacttc      300
accctgaaga ttagcagagt ggaagccgag gacgagggcg tgtacttctg tctgcaagtg      360
acccacgtgc catacacctt tggcggaggc accaagctgg aaatcaagag aacagtggcc      420
gctccgagcg tgttcatctt tccaccaagc gacgagcagc tgaaaagcgg cacagcctct      480
gtcgtgtgcc tgctgaacaa cttctacccc agagaagcca aggtgcagtg gaaggtggac      540
aatgccctgc agagcggcaa tagccaagag agcgtgaccg agcaggacag caaggatagc      600
acatacagcc tgagcagcac cctgacactg agcaaggccg actacgagaa gcacaaagtg      660
tacgcctgcg aagtgacaca ccagggcctg tctagccctg tgaccaagag cttcaaccgg      720
ggcgagtgct gatgatctag a                                                741
