                         SEQUENCE LISTING

<110>  Arbor Biotechnologies, Inc.
 
<120>  Compositions Comprising a Cas12i2 Polypeptide and Uses Thereof

<130>  51451-010WO3

<150>  US 63/107,172
<151>  2020-10-29

<150>  US 63/032,315
<151>  2020-05-29

<160>  175   

<170>  PatentIn version 3.5

<210>  1
<211>  3162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
atgagcagcg cgatcaaaag ctacaagagc gttctgcgtc cgaacgagcg taagaaccaa       60

ctgctgaaaa gcaccattca gtgcctggaa gacggtagcg cgttcttttt caagatgctg      120

caaggcctgt ttggtggcat caccccggag attgttcgtt tcagcaccga acaggagaaa      180

cagcaacagg atatcgcgct gtggtgcgcg gttaactggt tccgtccggt gagccaagac      240

agcctgaccc acaccattgc gagcgataac ctggtggaga agtttgagga atactatggt      300

ggcaccgcga gcgacgcgat caaacagtac ttcagcgcga gcattggcga aagctactat      360

tggaacgact gccgtcaaca gtactatgat ctgtgccgtg agctgggtgt tgaggtgagc      420

gacctgaccc atgatctgga gatcctgtgc cgtgaaaagt gcctggcggt tgcgaccgag      480

agcaaccaga acaacagcat cattagcgtt ctgtttggca ccggcgaaaa agaggaccgt      540

agcgtgaaac tgcgtatcac caagaaaatt ctggaggcga tcagcaacct gaaagaaatc      600

ccgaagaacg ttgcgccgat tcaagagatc attctgaacg tggcgaaagc gaccaaggaa      660

accttccgtc aggtgtatgc gggtaacctg ggtgcgccga gcaccctgga gaaatttatc      720

gcgaaggacg gccaaaaaga gttcgatctg aagaaactgc agaccgacct gaagaaagtt      780

attcgtggta aaagcaagga gcgtgattgg tgctgccagg aagagctgcg tagctacgtg      840

gagcaaaaca ccatccagta tgacctgtgg gcgtggggcg aaatgttcaa caaagcgcac      900

accgcgctga aaatcaagag cacccgtaac tacaactttg cgaagcaacg tctggaacag      960

ttcaaagaga ttcagagcct gaacaacctg ctggttgtga agaagctgaa cgactttttc     1020

gatagcgaat ttttcagcgg cgaggaaacc tacaccatct gcgttcacca tctgggtggc     1080

aaggacctga gcaaactgta taaggcgtgg gaggatgatc cggcggaccc ggaaaacgcg     1140

attgtggttc tgtgcgacga tctgaaaaac aactttaaga aagagccgat ccgtaacatt     1200

ctgcgttaca tcttcaccat tcgtcaagaa tgcagcgcgc aggacatcct ggcggcggcg     1260

aagtacaacc aacagctgga tcgttataaa agccaaaagg cgaacccgag cgttctgggt     1320

aaccagggct ttacctggac caacgcggtg atcctgccgg agaaggcgca gcgtaacgac     1380

cgtccgaaca gcctggatct gcgtatttgg ctgtacctga aactgcgtca cccggacggt     1440

cgttggaaga aacaccatat cccgttctac gatacccgtt tcttccaaga aatttatgcg     1500

gcgggcaaca gcccggttga cacctgccag tttcgtaccc cgcgtttcgg ttatcacctg     1560

ccgaaactga ccgatcagac cgcgatccgt gttaacaaga aacatgtgaa agcggcgaag     1620

accgaggcgc gtattcgtct ggcgatccaa cagggcaccc tgccggtgag caacctgaag     1680

atcaccgaaa ttagcgcgac catcaacagc aaaggtcaag tgcgtattcc ggttaagttt     1740

gacgtgggtc gtcaaaaagg caccctgcag atcggtgacc gtttctgcgg ctacgatcaa     1800

aaccagaccg cgagccacgc gtatagcctg tgggaagtgg ttaaagaggg tcaataccat     1860

aaagagctgg gctgctttgt tcgtttcatc agcagcggtg acatcgtgag cattaccgag     1920

aaccgtggca accaatttga tcagctgagc tatgaaggtc tggcgtaccc gcaatatgcg     1980

gactggcgta agaaagcgag caagttcgtg agcctgtggc agatcaccaa gaaaaacaag     2040

aaaaaggaaa tcgtgaccgt tgaagcgaaa gagaagtttg acgcgatctg caagtaccag     2100

ccgcgtctgt ataaattcaa caaggagtac gcgtatctgc tgcgtgatat tgttcgtggc     2160

aaaagcctgg tggaactgca acagattcgt caagagatct ttcgtttcat tgaacaggac     2220

tgcggtgtta cccgtctggg cagcctgagc ctgagcaccc tggaaaccgt gaaagcggtt     2280

aagggtatca tttacagcta ttttagcacc gcgctgaacg cgagcaagaa caacccgatc     2340

agcgacgaac agcgtaaaga gtttgatccg gaactgttcg cgctgctgga aaagctggag     2400

ctgattcgta cccgtaaaaa gaaacaaaaa gtggaacgta tcgcgaacag cctgattcag     2460

acctgcctgg agaacaacat caagttcatt cgtggtgaag gcgacctgag caccaccaac     2520

aacgcgacca agaaaaaggc gaacagccgt agcatggatt ggttggcgcg tggtgttttt     2580

aacaaaatcc gtcaactggc gccgatgcac aacattaccc tgttcggttg cggcagcctg     2640

tacaccagcc accaggaccc gctggtgcat cgtaacccgg ataaagcgat gaagtgccgt     2700

tgggcggcga tcccggttaa ggacattggc gattgggtgc tgcgtaagct gagccaaaac     2760

ctgcgtgcga aaaacatcgg caccggcgag tactatcacc aaggtgttaa agagttcctg     2820

agccattatg aactgcagga cctggaggaa gagctgctga agtggcgtag cgatcgtaaa     2880

agcaacattc cgtgctgggt gctgcagaac cgtctggcgg agaagctggg caacaaagaa     2940

gcggtggttt acatcccggt tcgtggtggc cgtatttatt ttgcgaccca caaggtggcg     3000

accggtgcgg tgagcatcgt tttcgaccaa aaacaagtgt gggtttgcaa cgcggatcat     3060

gttgcggcgg cgaacatcgc gctgaccgtg aagggtattg gcgaacaaag cagcgacgaa     3120

gagaacccgg atggtagccg tatcaaactg cagctgacca gc                        3162


<210>  2
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Asp Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Ile Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Val  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  3
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Arg Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  4
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Ser Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  5
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Gly 
    610                 615                 620                 


Cys Phe Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Glu  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Gly Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  6
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Arg 
    610                 615                 620                 


Cys Arg Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Pro Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Arg  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Gly Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  7
<211>  1054
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Met Ser Ser Ala Ile Lys Ser Tyr Lys Ser Val Leu Arg Pro Asn Glu 
1               5                   10                  15      


Arg Lys Asn Gln Leu Leu Lys Ser Thr Ile Gln Cys Leu Glu Asp Gly 
            20                  25                  30          


Ser Ala Phe Phe Phe Lys Met Leu Gln Gly Leu Phe Gly Gly Ile Thr 
        35                  40                  45              


Pro Glu Ile Val Arg Phe Ser Thr Glu Gln Glu Lys Gln Gln Gln Asp 
    50                  55                  60                  


Ile Ala Leu Trp Cys Ala Val Asn Trp Phe Arg Pro Val Ser Gln Asp 
65                  70                  75                  80  


Ser Leu Thr His Thr Ile Ala Ser Asp Asn Leu Val Glu Lys Phe Glu 
                85                  90                  95      


Glu Tyr Tyr Gly Gly Thr Ala Ser Asp Ala Ile Lys Gln Tyr Phe Ser 
            100                 105                 110         


Ala Ser Ile Gly Glu Ser Tyr Tyr Trp Asn Asp Cys Arg Gln Gln Tyr 
        115                 120                 125             


Tyr Asp Leu Cys Arg Glu Leu Gly Val Glu Val Ser Asp Leu Thr His 
    130                 135                 140                 


Asp Leu Glu Ile Leu Cys Arg Glu Lys Cys Leu Ala Val Ala Thr Glu 
145                 150                 155                 160 


Ser Asn Gln Asn Asn Ser Ile Ile Ser Val Leu Phe Gly Thr Gly Glu 
                165                 170                 175     


Lys Glu Asp Arg Ser Val Lys Leu Arg Ile Thr Lys Lys Ile Leu Glu 
            180                 185                 190         


Ala Ile Ser Asn Leu Lys Glu Ile Pro Lys Asn Val Ala Pro Ile Gln 
        195                 200                 205             


Glu Ile Ile Leu Asn Val Ala Lys Ala Thr Lys Glu Thr Phe Arg Gln 
    210                 215                 220                 


Val Tyr Ala Gly Asn Leu Gly Ala Pro Ser Thr Leu Glu Lys Phe Ile 
225                 230                 235                 240 


Ala Lys Asp Gly Gln Lys Glu Phe Asp Leu Lys Lys Leu Gln Thr Asp 
                245                 250                 255     


Leu Lys Lys Val Ile Arg Gly Lys Ser Lys Glu Arg Asp Trp Cys Cys 
            260                 265                 270         


Gln Glu Glu Leu Arg Ser Tyr Val Glu Gln Asn Thr Ile Gln Tyr Asp 
        275                 280                 285             


Leu Trp Ala Trp Gly Glu Met Phe Asn Lys Ala His Thr Ala Leu Lys 
    290                 295                 300                 


Ile Lys Ser Thr Arg Asn Tyr Asn Phe Ala Lys Gln Arg Leu Glu Gln 
305                 310                 315                 320 


Phe Lys Glu Ile Gln Ser Leu Asn Asn Leu Leu Val Val Lys Lys Leu 
                325                 330                 335     


Asn Asp Phe Phe Asp Ser Glu Phe Phe Ser Gly Glu Glu Thr Tyr Thr 
            340                 345                 350         


Ile Cys Val His His Leu Gly Gly Lys Asp Leu Ser Lys Leu Tyr Lys 
        355                 360                 365             


Ala Trp Glu Asp Asp Pro Ala Asp Pro Glu Asn Ala Ile Val Val Leu 
    370                 375                 380                 


Cys Asp Asp Leu Lys Asn Asn Phe Lys Lys Glu Pro Ile Arg Asn Ile 
385                 390                 395                 400 


Leu Arg Tyr Ile Phe Thr Ile Arg Gln Glu Cys Ser Ala Gln Asp Ile 
                405                 410                 415     


Leu Ala Ala Ala Lys Tyr Asn Gln Gln Leu Asp Arg Tyr Lys Ser Gln 
            420                 425                 430         


Lys Ala Asn Pro Ser Val Leu Gly Asn Gln Gly Phe Thr Trp Thr Asn 
        435                 440                 445             


Ala Val Ile Leu Pro Glu Lys Ala Gln Arg Asn Asp Arg Pro Asn Ser 
    450                 455                 460                 


Leu Asp Leu Arg Ile Trp Leu Tyr Leu Lys Leu Arg His Pro Asp Gly 
465                 470                 475                 480 


Arg Trp Lys Lys His His Ile Pro Phe Tyr Asp Thr Arg Phe Phe Gln 
                485                 490                 495     


Glu Ile Tyr Ala Ala Gly Asn Ser Pro Val Asp Thr Cys Gln Phe Arg 
            500                 505                 510         


Thr Pro Arg Phe Gly Tyr His Leu Pro Lys Leu Thr Asp Gln Thr Ala 
        515                 520                 525             


Ile Arg Val Asn Lys Lys His Val Lys Ala Ala Lys Thr Glu Ala Arg 
    530                 535                 540                 


Ile Arg Leu Ala Ile Gln Gln Gly Thr Leu Pro Val Ser Asn Leu Lys 
545                 550                 555                 560 


Ile Thr Glu Ile Ser Ala Thr Ile Asn Ser Lys Gly Gln Val Arg Ile 
                565                 570                 575     


Pro Val Lys Phe Arg Val Gly Arg Gln Lys Gly Thr Leu Gln Ile Gly 
            580                 585                 590         


Asp Arg Phe Cys Gly Tyr Asp Gln Asn Gln Thr Ala Ser His Ala Tyr 
        595                 600                 605             


Ser Leu Trp Glu Val Val Lys Glu Gly Gln Tyr His Lys Glu Leu Arg 
    610                 615                 620                 


Cys Arg Val Arg Phe Ile Ser Ser Gly Asp Ile Val Ser Ile Thr Glu 
625                 630                 635                 640 


Asn Arg Gly Asn Gln Phe Asp Gln Leu Ser Tyr Glu Gly Leu Ala Tyr 
                645                 650                 655     


Pro Gln Tyr Ala Asp Trp Arg Lys Lys Ala Ser Lys Phe Val Ser Leu 
            660                 665                 670         


Trp Gln Ile Thr Lys Lys Asn Lys Lys Lys Glu Ile Val Thr Val Glu 
        675                 680                 685             


Ala Lys Glu Lys Phe Asp Ala Ile Cys Lys Tyr Gln Pro Arg Leu Tyr 
    690                 695                 700                 


Lys Phe Asn Lys Glu Tyr Ala Tyr Leu Leu Arg Asp Ile Val Arg Gly 
705                 710                 715                 720 


Lys Ser Leu Val Glu Leu Gln Gln Ile Arg Gln Glu Ile Phe Arg Phe 
                725                 730                 735     


Ile Glu Gln Asp Cys Gly Val Thr Arg Leu Gly Ser Leu Ser Leu Ser 
            740                 745                 750         


Thr Leu Glu Thr Val Lys Ala Val Lys Gly Ile Ile Tyr Ser Tyr Phe 
        755                 760                 765             


Ser Thr Ala Leu Asn Ala Ser Lys Asn Asn Pro Ile Ser Asp Glu Gln 
    770                 775                 780                 


Arg Lys Glu Phe Asp Pro Glu Leu Phe Ala Leu Leu Glu Lys Leu Glu 
785                 790                 795                 800 


Leu Ile Arg Thr Arg Lys Lys Lys Gln Lys Val Glu Arg Ile Ala Asn 
                805                 810                 815     


Ser Leu Ile Gln Thr Cys Leu Glu Asn Asn Ile Lys Phe Ile Arg Gly 
            820                 825                 830         


Glu Gly Asp Leu Ser Thr Thr Asn Asn Ala Thr Lys Lys Lys Ala Asn 
        835                 840                 845             


Ser Arg Ser Met Asp Trp Leu Ala Arg Gly Val Phe Asn Lys Ile Arg 
    850                 855                 860                 


Gln Leu Ala Thr Met His Asn Ile Thr Leu Phe Gly Cys Gly Ser Leu 
865                 870                 875                 880 


Tyr Thr Ser His Gln Asp Pro Leu Val His Arg Asn Pro Asp Lys Ala 
                885                 890                 895     


Met Lys Cys Arg Trp Ala Ala Ile Pro Val Lys Asp Ile Gly Asp Trp 
            900                 905                 910         


Val Leu Arg Lys Leu Ser Gln Asn Leu Arg Ala Lys Asn Arg Gly Thr 
        915                 920                 925             


Gly Glu Tyr Tyr His Gln Gly Val Lys Glu Phe Leu Ser His Tyr Glu 
    930                 935                 940                 


Leu Gln Asp Leu Glu Glu Glu Leu Leu Lys Trp Arg Ser Asp Arg Lys 
945                 950                 955                 960 


Ser Asn Ile Pro Cys Trp Val Leu Gln Asn Arg Leu Ala Glu Lys Leu 
                965                 970                 975     


Gly Asn Lys Glu Ala Val Val Tyr Ile Pro Val Arg Gly Gly Arg Ile 
            980                 985                 990         


Tyr Phe Ala Thr His Lys Val Ala  Thr Gly Ala Val Ser  Ile Val Phe 
        995                 1000                 1005             


Asp Gln  Lys Gln Val Trp Val  Cys Asn Ala Asp His  Val Ala Ala 
    1010                 1015                 1020             


Ala Asn  Ile Ala Leu Thr Gly  Lys Gly Ile Gly Arg  Gln Ser Ser 
    1025                 1030                 1035             


Asp Glu  Glu Asn Pro Asp Gly  Gly Arg Ile Lys Leu  Gln Leu Thr 
    1040                 1045                 1050             


Ser 
    


<210>  8
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
guugcaaaac ccaagaaauc cgucuuucau ugacgg                                 36


<210>  9
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
aauagcggcc cuaagaaauc cgucuuucau ugacgg                                 36


<210>  10
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
auuggaacug gcgagaaauc cgucuuucau ugacgg                                 36


<210>  11
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
ccagcaacac cuaagaaauc cgucuuucau ugacgg                                 36


<210>  12
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
cggcgcucga auaggaaauc cgucuuucau ugacgg                                 36


<210>  13
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
guggcaacac cuaagaaauc cgucuuucau ugacgg                                 36


<210>  14
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
guugcaacac cuaagaaauc cgucuuucau ugacgg                                 36


<210>  15
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
guugcaaugc cuaagaaauc cgucuuucau ugacgg                                 36


<210>  16
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
gcaacaccua agaaauccgu cuuucauuga cggg                                   34


<210>  17
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
agaaauccgu cuuucauuga cgg                                               23


<210>  18
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a or g

<400>  18
ngaaauccgu cuuucauuga cgg                                               23


<210>  19
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19
ccgucuuuca uugacgg                                                      17


<210>  20
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20
gttgcaaaac ccaagaaatc cgtctttcat tgacgg                                 36


<210>  21
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21
ggaaaactcc ctttg                                                        15


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22
tgagaatggt gcgtcctagg                                                   20


<210>  23
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23
tgttcaccag gtcgt                                                        15


<210>  24
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24
cctcttccga tgttg                                                        15


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25
agcccctcca gccggtcctg                                                   20


<210>  26
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26
gactttgtct ccttc                                                        15


<210>  27
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27
tctgtctgca gcttg                                                        15


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28
tggcctgggt cacctctacg                                                   20


<210>  29
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29
gctggcccag atcct                                                        15


<210>  30
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30
ataccgtcgg cgttg                                                        15


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31
gtggagtcca gcacggcgcg                                                   20


<210>  32
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32
ggcgggcggc ggcgc                                                        15


<210>  33
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33
gacggcatgg ggttg                                                        15


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34
ggtgagggag gagagatgcc                                                   20


<210>  35
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35
cggagaggac ccaga                                                        15


<210>  36
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36
taggcagatt cctta                                                        15


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37
tctggtgaca cacccccatt                                                   20


<210>  38
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38
tcctggagcc atctc                                                        15


<210>  39
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39
gccgaggcgg ccttc                                                        15


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40
gtgagtggct tccctgccgc                                                   20


<210>  41
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41
ggccgccgcg ggcgc                                                        15


<210>  42
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42
gcatatacca gtttg                                                        15


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43
tggataaaac ttctcggagg                                                   20


<210>  44
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44
gttactcaga tcagt                                                        15


<210>  45
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  45
cctgactgtt ccttg                                                        15


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46
tgtgacctgt tcccacatct                                                   20


<210>  47
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  47
ggatgggctg cagga                                                        15


<210>  48
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48
ccaagccaga gattg                                                        15


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  49
tgtgagggcc tagtggggtg                                                   20


<210>  50
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50
ttcattgaga caggc                                                        15


<210>  51
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  51
tttcttaacg tattg                                                        15


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52
agaggtggga atcaggccca                                                   20


<210>  53
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  53
ggtagttcaa tggga                                                        15


<210>  54
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54
acggctggcg tgttc                                                        15


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  55
tcttgagatg ggctcgggct                                                   20


<210>  56
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56
acttggccag cttca                                                        15


<210>  57
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57
gggggagggt ggttg                                                        15


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58
gtgcccttcg gtcctcggca                                                   20


<210>  59
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  59
cccccctccg tctcc                                                        15


<210>  60
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60
gtggtgggca tattc                                                        15


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  61
tgtgcccgtg gggacccccg                                                   20


<210>  62
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62
gttgtgtcct gttcg                                                        15


<210>  63
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  63
ggagcgtgta cgttg                                                        15


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64
gtgcccgctg ctgtctaatg                                                   20


<210>  65
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  65
ccctggagcc tccct                                                        15


<210>  66
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66
aaagttcatg gtttc                                                        15


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67
ggaggcccga ccggggccgg                                                   20


<210>  68
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68
cgcggctcgc gctcc                                                        15


<210>  69
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  69
attttcagag gcttg                                                        15


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70
tgagtgctcc gtgttaaggg                                                   20


<210>  71
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  71
gcaggtagga tgggg                                                        15


<210>  72
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72
caaacaaatg ctttc                                                        15


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  73
tccgctctga gcaaggccca                                                   20


<210>  74
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74
cagggactgc aaaaa                                                        15


<210>  75
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct


<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  n is any nucleotide (A, T, C, or G)

<400>  75
nnnnnnnn                                                                 8


<210>  76
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76
tgagaatggt gcgtcctagg                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  77
agcccctcca gccggtcctg                                                   20


<210>  78
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78
tggcctgggt cacctctacg                                                   20


<210>  79
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  79
gtggagtcca gcacggcgcg                                                   20


<210>  80
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80
ggtgagggag gagagatgcc                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  81
tctggtgaca cacccccatt                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  82
gtgagtggct tccctgccgc                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  83
tggataaaac ttctcggagg                                                   20


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  84
tgtgacctgt tcccacatct                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  85
tgtgagggcc tagtggggtg                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  86
agaggtggga atcaggccca                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  87
tcttgagatg ggctcgggct                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  88
gtgcccttcg gtcctcggca                                                   20


<210>  89
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  89
tgtgcccgtg gggacccccg                                                   20


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  90
gtgcccgctg ctgtctaatg                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  91
ggaggcccga ccggggccgg                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  92
tgagtgctcc gtgttaaggg                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  93
tccgctctga gcaaggccca                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  94
gtagcctctc ccgctctggt                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  95
ggggaggcct ggagtcatgg                                                   20


<210>  96
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  96
agaaatccgt ctttcattga cgggtagcct ctcccgctct ggt                         43


<210>  97
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  97
agaaauccgu cuuucauuga cggcuagccu cucccgcucu ggu                         43


<210>  98
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  98
agaaauccgu cuuucauuga cgggaagccu cucccgcucu ggu                         43


<210>  99
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  99
agaaauccgu cuuucauuga cggguugccu cucccgcucu ggu                         43


<210>  100
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  100
agaaauccgu cuuucauuga cggguacccu cucccgcucu ggu                         43


<210>  101
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  101
agaaauccgu cuuucauuga cggguaggcu cucccgcucu ggu                         43


<210>  102
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  102
agaaauccgu cuuucauuga cggguagcgu cucccgcucu ggu                         43


<210>  103
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  103
agaaauccgu cuuucauuga cggguagcca cucccgcucu ggu                         43


<210>  104
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  104
agaaauccgu cuuucauuga cggguagccu gucccgcucu ggu                         43


<210>  105
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  105
agaaauccgu cuuucauuga cggguagccu cacccgcucu ggu                         43


<210>  106
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  106
agaaauccgu cuuucauuga cggguagccu cugccgcucu ggu                         43


<210>  107
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  107
agaaauccgu cuuucauuga cggguagccu cucgcgcucu ggu                         43


<210>  108
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  108
agaaauccgu cuuucauuga cggguagccu cuccggcucu ggu                         43


<210>  109
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  109
agaaauccgu cuuucauuga cggguagccu cucccccucu ggu                         43


<210>  110
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  110
agaaauccgu cuuucauuga cggguagccu cucccggucu ggu                         43


<210>  111
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  111
agaaauccgu cuuucauuga cggguagccu cucccgcacu ggu                         43


<210>  112
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  112
agaaauccgu cuuucauuga cggguagccu cucccgcugu ggu                         43


<210>  113
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  113
agaaauccgu cuuucauuga cggguagccu cucccgcuca ggu                         43


<210>  114
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  114
agaaauccgu cuuucauuga cggguagccu cucccgcucu cgu                         43


<210>  115
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  115
agaaauccgu cuuucauuga cggguagccu cucccgcucu gcu                         43


<210>  116
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  116
agaaauccgu cuuucauuga cggguagccu cucccgcucu gga                         43


<210>  117
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  117
agaaauccgu cuuucauuga cggcaagccu cucccgcucu ggu                         43


<210>  118
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  118
agaaauccgu cuuucauuga cgggaugccu cucccgcucu ggu                         43


<210>  119
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  119
agaaauccgu cuuucauuga cggguucccu cucccgcucu ggu                         43


<210>  120
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  120
agaaauccgu cuuucauuga cggguacgcu cucccgcucu ggu                         43


<210>  121
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  121
agaaauccgu cuuucauuga cggguagggu cucccgcucu ggu                         43


<210>  122
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  122
agaaauccgu cuuucauuga cggguagcga cucccgcucu ggu                         43


<210>  123
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  123
agaaauccgu cuuucauuga cggguagcca gucccgcucu ggu                         43


<210>  124
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  124
agaaauccgu cuuucauuga cggguagccu gacccgcucu ggu                         43


<210>  125
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  125
agaaauccgu cuuucauuga cggguagccu cagccgcucu ggu                         43


<210>  126
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  126
agaaauccgu cuuucauuga cggguagccu cuggcgcucu ggu                         43


<210>  127
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  127
agaaauccgu cuuucauuga cggguagccu cucgggcucu ggu                         43


<210>  128
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  128
agaaauccgu cuuucauuga cggguagccu cuccgccucu ggu                         43


<210>  129
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  129
agaaauccgu cuuucauuga cggguagccu cuccccgucu ggu                         43


<210>  130
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  130
agaaauccgu cuuucauuga cggguagccu cucccggacu ggu                         43


<210>  131
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  131
agaaauccgu cuuucauuga cggguagccu cucccgcagu ggu                         43


<210>  132
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  132
agaaauccgu cuuucauuga cggguagccu cucccgcuga ggu                         43


<210>  133
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  133
agaaauccgu cuuucauuga cggguagccu cucccgcuca cgu                         43


<210>  134
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  134
agaaauccgu cuuucauuga cggguagccu cucccgcucu ccu                         43


<210>  135
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  135
agaaauccgu cuuucauuga cggguagccu cucccgcucu gca                         43


<210>  136
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  136
agaaauccgu cuuucauuga cggggggagg ccuggaguca ugg                         43


<210>  137
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  137
agaaauccgu cuuucauuga cggcgggagg ccuggaguca ugg                         43


<210>  138
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  138
agaaauccgu cuuucauuga cgggcggagg ccuggaguca ugg                         43


<210>  139
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  139
agaaauccgu cuuucauuga cggggcgagg ccuggaguca ugg                         43


<210>  140
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  140
agaaauccgu cuuucauuga cgggggcagg ccuggaguca ugg                         43


<210>  141
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  141
agaaauccgu cuuucauuga cggggggugg ccuggaguca ugg                         43


<210>  142
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  142
agaaauccgu cuuucauuga cggggggacg ccuggaguca ugg                         43


<210>  143
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  143
agaaauccgu cuuucauuga cggggggagc ccuggaguca ugg                         43


<210>  144
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  144
agaaauccgu cuuucauuga cggggggagg gcuggaguca ugg                         43


<210>  145
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  145
agaaauccgu cuuucauuga cggggggagg cguggaguca ugg                         43


<210>  146
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  146
agaaauccgu cuuucauuga cggggggagg ccaggaguca ugg                         43


<210>  147
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  147
agaaauccgu cuuucauuga cggggggagg ccucgaguca ugg                         43


<210>  148
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  148
agaaauccgu cuuucauuga cggggggagg ccugcaguca ugg                         43


<210>  149
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  149
agaaauccgu cuuucauuga cggggggagg ccugguguca ugg                         43


<210>  150
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  150
agaaauccgu cuuucauuga cggggggagg ccuggacuca ugg                         43


<210>  151
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  151
agaaauccgu cuuucauuga cggggggagg ccuggagaca ugg                         43


<210>  152
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  152
agaaauccgu cuuucauuga cggggggagg ccuggaguga ugg                         43


<210>  153
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  153
agaaauccgu cuuucauuga cggggggagg ccuggagucu ugg                         43


<210>  154
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  154
agaaauccgu cuuucauuga cggggggagg ccuggaguca agg                         43


<210>  155
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  155
agaaauccgu cuuucauuga cggggggagg ccuggaguca ucg                         43


<210>  156
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  156
agaaauccgu cuuucauuga cggggggagg ccuggaguca ugc                         43


<210>  157
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  157
agaaauccgu cuuucauuga cggccggagg ccuggaguca ugg                         43


<210>  158
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  158
agaaauccgu cuuucauuga cgggccgagg ccuggaguca ugg                         43


<210>  159
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  159
agaaauccgu cuuucauuga cggggccagg ccuggaguca ugg                         43


<210>  160
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  160
agaaauccgu cuuucauuga cgggggcugg ccuggaguca ugg                         43


<210>  161
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  161
agaaauccgu cuuucauuga cggggggucg ccuggaguca ugg                         43


<210>  162
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  162
agaaauccgu cuuucauuga cggggggacc ccuggaguca ugg                         43


<210>  163
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  163
agaaauccgu cuuucauuga cggggggagc gcuggaguca ugg                         43


<210>  164
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  164
agaaauccgu cuuucauuga cggggggagg gguggaguca ugg                         43


<210>  165
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  165
agaaauccgu cuuucauuga cggggggagg cgaggaguca ugg                         43


<210>  166
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  166
agaaauccgu cuuucauuga cggggggagg ccacgaguca ugg                         43


<210>  167
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  167
agaaauccgu cuuucauuga cggggggagg ccuccaguca ugg                         43


<210>  168
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  168
agaaauccgu cuuucauuga cggggggagg ccugcuguca ugg                         43


<210>  169
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  169
agaaauccgu cuuucauuga cggggggagg ccuggucuca ugg                         43


<210>  170
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  170
agaaauccgu cuuucauuga cggggggagg ccuggacaca ugg                         43


<210>  171
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  171
agaaauccgu cuuucauuga cggggggagg ccuggagaga ugg                         43


<210>  172
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  172
agaaauccgu cuuucauuga cggggggagg ccuggagugu ugg                         43


<210>  173
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  173
agaaauccgu cuuucauuga cggggggagg ccuggagucu agg                         43


<210>  174
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  174
agaaauccgu cuuucauuga cggggggagg ccuggaguca acg                         43


<210>  175
<211>  43
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  175
agaaauccgu cuuucauuga cggggggagg ccuggaguca ucc                         43


