                         SEQUENCE LISTING

<110>  MODERNATX, INC.
 
<120>  USE OF MRNAS ENCODING OX40L, IL-23 AND IL-36GAMMA FOR TREATING 
       CANCER

<130>  MRNA-146/001WO 324673-2761

<140>  PCT/US2021/034858
<141>  2021-05-28

<150>  US 63/031,307
<151>  2020-05-28

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  2
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  3
<211>  198
<212>  PRT
<213>  Mus musculus

<400>  3

Met Glu Gly Glu Gly Val Gln Pro Leu Asp Glu Asn Leu Glu Asn Gly 
1               5                   10                  15      


Ser Arg Pro Arg Phe Lys Trp Lys Lys Thr Leu Arg Leu Val Val Ser 
            20                  25                  30          


Gly Ile Lys Gly Ala Gly Met Leu Leu Cys Phe Ile Tyr Val Cys Leu 
        35                  40                  45              


Gln Leu Ser Ser Ser Pro Ala Lys Asp Pro Pro Ile Gln Arg Leu Arg 
    50                  55                  60                  


Gly Ala Val Thr Arg Cys Glu Asp Gly Gln Leu Phe Ile Ser Ser Tyr 
65                  70                  75                  80  


Lys Asn Glu Tyr Gln Thr Met Glu Val Gln Asn Asn Ser Val Val Ile 
                85                  90                  95      


Lys Cys Asp Gly Leu Tyr Ile Ile Tyr Leu Lys Gly Ser Phe Phe Gln 
            100                 105                 110         


Glu Val Lys Ile Asp Leu His Phe Arg Glu Asp His Asn Pro Ile Ser 
        115                 120                 125             


Ile Pro Met Leu Asn Asp Gly Arg Arg Ile Val Phe Thr Val Val Ala 
    130                 135                 140                 


Ser Leu Ala Phe Lys Asp Lys Val Tyr Leu Thr Val Asn Ala Pro Asp 
145                 150                 155                 160 


Thr Leu Cys Glu His Leu Gln Ile Asn Asp Gly Glu Leu Ile Val Val 
                165                 170                 175     


Gln Leu Thr Pro Gly Tyr Cys Ala Pro Glu Gly Ser Tyr His Ser Thr 
            180                 185                 190         


Val Asn Gln Val Pro Leu 
        195             


<210>  4
<211>  549
<212>  RNA
<213>  Homo sapiens

<400>  4
auggaaaggg uccaaccccu ggaagagaau gugggaaaug cagccaggcc aagauucgag       60

aggaacaagc uauugcuggu ggccucugua auucagggac uggggcugcu ccugugcuuc      120

accuacaucu gccugcacuu cucugcucuu cagguaucac aucgguaucc ucgaauucaa      180

aguaucaaag uacaauuuac cgaauauaag aaggagaaag guuucauccu cacuucccaa      240

aaggaggaug aaaucaugaa ggugcagaac aacucaguca ucaucaacug ugauggguuu      300

uaucucaucu cccugaaggg cuacuucucc caggaaguca acauuagccu ucauuaccag      360

aaggaugagg agccccucuu ccaacugaag aaggucaggu cugucaacuc cuugauggug      420

gccucucuga cuuacaaaga caaagucuac uugaauguga ccacugacaa uaccucccug      480

gaugacuucc augugaaugg cggagaacug auucuuaucc aucaaaaucc uggugaauuc      540

uguguccuu                                                              549


<210>  5
<211>  843
<212>  RNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanine nucleotide methylated at the 7 position

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  joined by a triphosphate linkage at their 5' positions

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2' O-methylated

<400>  5
ggggaaauaa gagagaaaag aagaguaaga agaaauauaa gagccaccau ggaaaggguc       60

caaccccugg aagagaaugu gggaaaugca gccaggccaa gauucgagag gaacaagcua      120

uugcuggugg ccucuguaau ucagggacug gggcugcucc ugugcuucac cuacaucugc      180

cugcacuucu cugcucuuca gguaucacau cgguauccuc gaauucaaag uaucaaagua      240

caauuuaccg aauauaagaa ggagaaaggu uucauccuca cuucccaaaa ggaggaugaa      300

aucaugaagg ugcagaacaa cucagucauc aucaacugug auggguuuua ucucaucucc      360

cugaagggcu acuucuccca ggaagucaac auuagccuuc auuaccagaa ggaugaggag      420

ccccucuucc aacugaagaa ggucaggucu gucaacuccu ugaugguggc cucucugacu      480

uacaaagaca aagucuacuu gaaugugacc acugacaaua ccucccugga ugacuuccau      540

gugaauggcg gagaacugau ucuuauccau caaaauccug gugaauucug uguccuuuga      600

uaauaggcug gagccucggu ggccaugcuu cuugccccuu gggccucccc ccagccccuc      660

cuccccuucc ugcacccgua ccccccaaac accauuguca cacuccagug gucuuugaau      720

aaagucugag ugggcggcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaauc      840

uag                                                                    843


<210>  6
<211>  3484
<212>  RNA
<213>  Homo sapiens

<400>  6
ggcccuggga ccuuugccua uuuucugauu gauaggcuuu guuuugucuu uaccuccuuc       60

uuucugggga aaacuucagu uuuaucgcac guuccccuuu uccauaucuu caucuucccu      120

cuacccagau ugugaagaug gaaagggucc aaccccugga agagaaugug ggaaaugcag      180

ccaggccaag auucgagagg aacaagcuau ugcugguggc cucuguaauu cagggacugg      240

ggcugcuccu gugcuucacc uacaucugcc ugcacuucuc ugcucuucag guaucacauc      300

gguauccucg aauucaaagu aucaaaguac aauuuaccga auauaagaag gagaaagguu      360

ucauccucac uucccaaaag gaggaugaaa ucaugaaggu gcagaacaac ucagucauca      420

ucaacuguga uggguuuuau cucaucuccc ugaagggcua cuucucccag gaagucaaca      480

uuagccuuca uuaccagaag gaugaggagc cccucuucca acugaagaag gucaggucug      540

ucaacuccuu gaugguggcc ucucugacuu acaaagacaa agucuacuug aaugugacca      600

cugacaauac cucccuggau gacuuccaug ugaauggcgg agaacugauu cuuauccauc      660

aaaauccugg ugaauucugu guccuuugag gggcugaugg caauaucuaa aaccaggcac      720

cagcaugaac accaagcugg ggguggacag ggcauggauu cuucauugca agugaaggag      780

ccucccagcu cagccacgug ggaugugaca agaagcagau ccuggcccuc ccgcccccac      840

cccucaggga uauuuaaaac uuauuuuaua uaccaguuaa ucuuauuuau ccuuauauuu      900

ucuaaauugc cuagccguca caccccaaga uugccuugag ccuacuaggc accuuuguga      960

gaaagaaaaa auagaugccu cuucuucaag augcauuguu ucuauugguc aggcaauugu     1020

cauaauaaac uuaugucauu gaaaacggua ccugacuacc auuugcugga aauuugacau     1080

guguguggca uuaucaaaau gaagaggagc aaggagugaa ggaguggggu uaugaaucug     1140

ccaaaggugg uaugaaccaa ccccuggaag ccaaagcggc cucuccaagg uuaaauugau     1200

ugcaguuugc auauugccua aauuuaaacu uucucauuug guggggguuc aaaagaagaa     1260

ucagcuugug aaaaaucagg acuugaagag agccgucuaa gaaauaccac gugcuuuuuu     1320

ucuuuaccau uuugcuuucc cagccuccaa acauaguuaa uagaaauuuc ccuucaaaga     1380

acugucuggg gaugugaugc uuugaaaaau cuaaucagug acuuaagaga gauuuucuug     1440

uauacaggga gagugagaua acuuauugug aaggguuagc uuuacuguac aggauagcag     1500

ggaacuggac aucucagggu aaaagucagu acggauuuua auagccuggg gaggaaaaca     1560

cauucuuugc cacagacagg caaagcaaca caugcucauc cuccugccua ugcugagaua     1620

cgcacucagc uccaugucuu guacacacag aaacauugcu gguuucaaga aaugagguga     1680

uccuauuauc aaauucaauc ugaugucaaa uagcacuaag aaguuauugu gccuuaugaa     1740

aaauaaugau cucugucuag aaauaccaua gaccauauau agucucacau ugauaauuga     1800

aacuagaagg gucuauaauc agccuaugcc agggcuucaa uggaauagua uccccuuaug     1860

uuuaguugaa auguccccuu aacuugauau aauguguuau gcuuauggcg cuguggacaa     1920

ucugauuuuu caugucaacu uuccagauga uuuguaacuu cucugugcca aaccuuuuau     1980

aaacauaaau uuuugagaua uguauuuuaa aauuguagca cauguuuccc ugacauuuuc     2040

aauagaggau acaacaucac agaaucuuuc uggaugauuc uguguuauca aggaauugua     2100

cugugcuaca auuaucucua gaaucuccag aaagguggag ggcuguucgc ccuuacacua     2160

aauggucuca guuggauuuu uuuuuccugu uuucuauuuc cucuuaagua caccuucaac     2220

uauauuccca ucccucuauu uuaaucuguu augaaggaag guaaauaaaa augcuaaaua     2280

gaagaaauug uagguaaggu aagaggaauc aaguucugag uggcugccaa ggcacucaca     2340

gaaucauaau cauggcuaaa uauuuaugga gggccuacug uggaccaggc acugggcuaa     2400

auacuuacau uuacaagaau cauucugaga cagauauuca augauaucug gcuucacuac     2460

ucagaagauu gugugugugu uugugugugu gugugugugu guauuucacu uuuuguuauu     2520

gaccauguuc ugcaaaauug caguuacuca gugagugaua uccgaaaaag uaaacguuua     2580

ugacuauagg uaauauuuaa gaaaaugcau gguucauuuu uaaguuugga auuuuuaucu     2640

auauuucuca cagaugugca gugcacaugc aggccuaagu auauguugug uguguuguuu     2700

gucuuugaug ucaugguccc cucucuuagg ugcucacucg cuuugggugc accuggccug     2760

cucuucccau guuggccucu gcaaccacac agggauauuu cugcuaugca ccagccucac     2820

uccaccuucc uuccaucaaa aauaugugug ugugucucag ucccuguaag ucauguccuu     2880

cacagggaga auuaacccuu cgauauacau ggcagaguuu ugugggaaaa gaauugaaug     2940

aaaagucagg agaucagaau uuuaaauuug acuuagccac uaacuagcca uguaaccuug     3000

ggaaagucau uucccauuuc ugggucuugc uuuucuuucu guuaaaugag aggaauguua     3060

aauaucuaac aguuuagaau cuuaugcuua caguguuauc ugugaaugca cauauuaaau     3120

gucuauguuc uuguugcuau gagucaagga guguaaccuu cuccuuuacu auguugaaug     3180

uauuuuuuuc uggacaagcu uacaucuucc ucagccaucu uugugagucc uucaagagca     3240

guuaucaauu guuaguuaga uauuuucuau uuagagaaug cuuaagggau uccaaucccg     3300

auccaaauca uaauuuguuc uuaaguauac ugggcagguc cccuauuuua agucauaauu     3360

uuguauuuag ugcuuuccug gcucucagag aguauuaaua uugauauuaa uaauauaguu     3420

aauaguaaua uugcuauuua cauggaaaca aauaaaagau cucagaauuc acuaaaaaaa     3480

aaaa                                                                  3484


<210>  7
<211>  737
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human OX40L with 5'-UTR, 3'-UTR, and miR-122 binding site

<400>  7
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gaaagggucc       60

aaccccugga agagaaugug ggaaaugcag ccaggccaag auucgagagg aacaagcuau      120

ugcugguggc cucuguaauu cagggacugg ggcugcuccu gugcuucacc uacaucugcc      180

ugcacuucuc ugcucuucag guaucacauc gguauccucg aauucaaagu aucaaaguac      240

aauuuaccga auauaagaag gagaaagguu ucauccucac uucccaaaag gaggaugaaa      300

ucaugaaggu gcagaacaac ucagucauca ucaacuguga uggguuuuau cucaucuccc      360

ugaagggcua cuucucccag gaagucaaca uuagccuuca uuaccagaag gaugaggagc      420

cccucuucca acugaagaag gucaggucug ucaacuccuu gaugguggcc ucucugacuu      480

acaaagacaa agucuacuug aaugugacca cugacaauac cucccuggau gacuuccaug      540

ugaauggcgg agaacugauu cuuauccauc aaaauccugg ugaauucugu guccuuugau      600

aauaggcugg agccucggug gccaugcuuc uugccccuug ggccuccccc cagccccucc      660

uccccuuccu gcacccguac cccccaaaca ccauugucac acuccagugg ucuuugaaua      720

aagucugagu gggcggc                                                     737


<210>  8
<211>  549
<212>  RNA
<213>  Homo sapiens

<400>  8
auggagcggg ugcagccccu ggaggagaac gugggcaacg ccgcucggcc acgguucgag       60

cggaacaagc ugcugcuggu ggcuagcgug auccagggcc ugggccugcu gcugugcuuc      120

accuacaucu gccugcacuu cagcgcccug caggugagcc accgguaucc ccggauccag      180

agcaucaagg ugcaguucac cgaguacaag aaggagaagg gcuucauccu gaccagccag      240

aaggaggacg agaucaugaa ggugcagaac aacagcguga ucaucaacug cgacggcuuc      300

uaccugauca gccugaaggg cuacuucagc caggagguga acaucagccu gcacuaccag      360

aaggacgagg agccccuguu ccagcugaag aaggugcgga gcgugaacag ccugauggug      420

gccagccuga ccuacaagga caagguguac cugaacguga ccaccgacaa caccagccug      480

gacgacuucc acgugaacgg cggcgagcug auccugaucc accagaaccc cggcgaguuc      540

ugcgugcug                                                              549


<210>  9
<211>  549
<212>  RNA
<213>  Homo sapiens

<400>  9
auggaaaggg uccaaccccu cgaagagaac gugggaaacg cagccaggcc aagauucgag       60

aggaacaagc uauugcucgu ggccucagua auucagggac ucggguuacu ccuuugcuuc      120

accuacaucu gcuugcacuu cagugcucug cagguaucac aucgguaucc ucgaauucaa      180

aguaucaaag uacaauuuac cgaauauaag aaggagaaag guuucauccu cacuucccag      240

aaggaggaug aaaucaugaa ggugcagaac aacucaguca ucaucaacug ugauggguuu      300

uaucucaucu cccugaaggg cuacuucucc caggaaguca acauuagccu ucauuaccag      360

aaggaugagg agccccucuu ccaacugaag aaggucaggu cugucaacuc cuugauggua      420

gccucucuga cuuacaaaga caaagucuac uugaauguga ccacugacaa uaccucccug      480

gaugacuucc augugaaugg cggagaacug auucuuaucc aucagaaucc uggugaauuc      540

uguguccuu                                                              549


<210>  10
<211>  549
<212>  RNA
<213>  Homo sapiens

<400>  10
auggagcggg ugcagccccu ggaggagaac gugggcaacg ccgcucggcc acgguucgag       60

cggaacaagc ugcugcuggu ggcuagcgug auccagggcc ugggccugcu gcugugcuuc      120

accuacaucu gccugcacuu cagcgcccug caggugagcc accgguaucc ccggauccag      180

agcaucaagg ugcaguucac cgaguacaag aaggagaagg gcuucauccu gaccagccag      240

aaggaggacg agaucaugaa ggugcagaac aacagcguga ucaucaacug cgacggcuuc      300

uaccugauca gccugaaggg cuacuucagc caggagguga acaucagccu gcacuaccag      360

aaggacgagg agccccuguu ccagcugaag aaggugcgga gcgugaacag ccugauggug      420

gccagccuga ccuacaagga caagguguac cugaacguga ccaccgacaa caccagccug      480

gacgacuucc acgugaacgg cggcgagcug auccugaucc accagaaccc cggcgaguuc      540

ugcgugcug                                                              549


<210>  11
<211>  57
<212>  RNA
<213>  Unknown

<220>
<223>  5' UTR

<400>  11
aggaaauaag agagaaaaga agaguaagaa gaaauauaag accccggcgc cgccacc          57


<210>  12
<211>  85
<212>  RNA
<213>  Homo sapiens

<400>  12
ccuuagcaga gcuguggagu gugacaaugg uguuuguguc uaaacuauca aacgccauua       60

ucacacuaaa uagcuacugc uaggc                                             85


<210>  13
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  13
aacgccauua ucacacuaaa ua                                                22


<210>  14
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  14
uauuuagugu gauaauggcg uu                                                22


<210>  15
<211>  92
<212>  RNA
<213>  Unknown

<220>
<223>  5' UTR

<400>  15
ucaagcuuuu ggacccucgu acagaagcua auacgacuca cuauagggaa auaagagaga       60

aaagaagagu aagaagaaau auaagagcca cc                                     92


<210>  16
<211>  47
<212>  RNA
<213>  Unknown

<220>
<223>  5' UTR

<400>  16
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  17
<211>  141
<212>  RNA
<213>  Unknown

<220>
<223>  3' UTR

<400>  17
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccca aacaccauug ucacacucca guggucuuug      120

aauaaagucu gagugggcgg c                                                141


<210>  18
<211>  164
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' UTR with mi-122 and mi-142.3p sites

<400>  18
ugauaauagg cuggagccuc gguggccaug cuucuugccc cuugggccca aacaccauug       60

ucacacucca uccccccagc cccuccuccc cuuccuccau aaaguaggaa acacuacaug      120

cacccguacc cccguggucu uugaauaaag ucugaguggg cggc                       164


<210>  19
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  19
uggaguguga caaugguguu ug                                                22


<210>  20
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  20
caaacaccau ugucacacuc ca                                                22


<210>  21
<211>  7
<212>  RNA
<213>  Unknown

<220>
<223>  Kozak Consensus

<400>  21
gccagcc                                                                  7


<210>  22
<211>  141
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3' UTR with miR-122

<400>  22
ugauaauagg cuggagccuc gguggccuag cuucuugccc cuugggccuc cccccagccc       60

cuccuccccu uccugcaccc guacccccca aacaccauug ucacacucca guggucuuug      120

aauaaagucu gagugggcgg c                                                141


<210>  23
<211>  47
<212>  DNA
<213>  Unknown

<220>
<223>  standard UTR

<400>  23
gggaaataag agagaaaaga agagtaagaa gaaatataag agccacc                     47


<210>  24
<211>  505
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IL-23 (IL-12p40 subunit and IL-23p19 subunit linked by GS 
       Linker)

<400>  24

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg 
                325                 330                 335     


Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln Cys Gln Gln Leu 
            340                 345                 350         


Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His Pro Leu Val Gly 
        355                 360                 365             


His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr Thr Asn Asp Val 
    370                 375                 380                 


Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln Gly Leu Arg Asp 
385                 390                 395                 400 


Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly Leu Ile Phe Tyr 
                405                 410                 415     


Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu Pro Ser Leu Leu 
            420                 425                 430         


Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu Leu Gly Leu Ser 
        435                 440                 445             


Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr Gln Gln Ile Pro 
    450                 455                 460                 


Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu Leu Arg Phe Lys 
465                 470                 475                 480 


Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala Ala Arg Val Phe 
                485                 490                 495     


Ala His Gly Ala Ala Thr Leu Ser Pro 
            500                 505 


<210>  25
<211>  1515
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  human IL-23 (IL-12p40 subunit and IL-23p19 subunit linked by GS 
       Linker)

<400>  25
augugucacc agcaguuggu caucucuugg uuuucccugg uauuucuggc aucuccccuc       60

guggccauau gggaacugaa gaaagauguu uaugucguag aauuggauug guauccggau      120

gccccuggag aaaugguggu ccucaccugu gacaccccug aagaagaugg uaucaccugg      180

accuuggacc agagcaguga ggucuuaggc ucuggcaaga cccugaccau ccaagucaaa      240

gaguuuggag augcuggcca guacaccugu cacaaaggag gcgagguucu aagccauucg      300

cuccugcugc uucacaagaa ggaagaugga auuuggucca cugauauuuu aaaggaccag      360

aaagaaccca agaauaagac cuuucuaaga ugcgaggcca agaauuauuc uggacguuuc      420

accugcuggu ggcugacgac aaucaguacu gauuugacau ucagugucaa gagcagcaga      480

ggcucuucug acccccaagg ggugacgugc ggagcugcua cacucucugc agagagaguc      540

agaggggaca acaaggagua ugaguacuca guggagugcc aggaggacag ugccugccca      600

gcugcugagg agagucugcc cauugagguc augguggaug ccguucacaa gcucaaguau      660

gagaacuaca ccagcagcuu cuucaucagg gacaucauca aaccugaccc acccaagaac      720

uugcagcuga agccauuaaa gaauucucgg cagguggagg ucagcuggga guacccugac      780

accuggagua cuccacauuc cuacuucucc cugacauucu gcguucaggu ccagggcaag      840

agcaagagag agaagaaaga uagagucuuc acggacaaga ccucagccac ggucaucugc      900

cgcaagaaug ccagcauuag cgugcgggcc caggaccgcu acuauagcuc aucuuggagc      960

gaaugggcau cugugcccug caguggcgga gggggcggag ggagcagagc ugugccuggg     1020

ggcagcagcc cugccuggac ucagugccag cagcuuucac agaagcucug cacacuggcc     1080

uggagugcac auccacuagu gggacacaug gaucuaagag aagagggaga ugaagagacu     1140

acaaaugaug uuccccauau ccagugugga gauggcugug acccccaagg acucagggac     1200

aacagucagu ucugcuugca aaggauccac cagggucuga ucuuuuauga gaagcugcua     1260

ggaucggaua uuuucacagg ggagccuucu cugcucccug auagcccugu gggccagcuu     1320

caugccuccc uacugggccu cagccaacuc cugcagccug agggucacca cugggagacu     1380

cagcagauuc caagccucag ucccagccag ccauggcagc gucuccuucu ccgcuucaag     1440

auccuucgca gccuccaggc cuuuguggcu guagccgccc gggucuuugc ccauggagca     1500

gcaacccuga guccc                                                      1515


<210>  26
<211>  1809
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  human IL-23 (IL-12p40 subunit and IL-23p19 subunit linked by GS 
       Linker)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanine nucleotide methylated at the 7 position

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  joined by a triphosphate linkage at their 5' positions

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2' O-methylated

<400>  26
ggggaaauaa gagagaaaag aagaguaaga agaaauauaa gagccaccau gugucaccag       60

caguugguca ucucuugguu uucccuggua uuucuggcau cuccccucgu ggccauaugg      120

gaacugaaga aagauguuua ugucguagaa uuggauuggu auccggaugc cccuggagaa      180

augguggucc ucaccuguga caccccugaa gaagauggua ucaccuggac cuuggaccag      240

agcagugagg ucuuaggcuc uggcaagacc cugaccaucc aagucaaaga guuuggagau      300

gcuggccagu acaccuguca caaaggaggc gagguucuaa gccauucgcu ccugcugcuu      360

cacaagaagg aagauggaau uugguccacu gauauuuuaa aggaccagaa agaacccaag      420

aauaagaccu uucuaagaug cgaggccaag aauuauucug gacguuucac cugcuggugg      480

cugacgacaa ucaguacuga uuugacauuc agugucaaga gcagcagagg cucuucugac      540

ccccaagggg ugacgugcgg agcugcuaca cucucugcag agagagucag aggggacaac      600

aaggaguaug aguacucagu ggagugccag gaggacagug ccugcccagc ugcugaggag      660

agucugccca uugaggucau gguggaugcc guucacaagc ucaaguauga gaacuacacc      720

agcagcuucu ucaucaggga caucaucaaa ccugacccac ccaagaacuu gcagcugaag      780

ccauuaaaga auucucggca gguggagguc agcugggagu acccugacac cuggaguacu      840

ccacauuccu acuucucccu gacauucugc guucaggucc agggcaagag caagagagag      900

aagaaagaua gagucuucac ggacaagacc ucagccacgg ucaucugccg caagaaugcc      960

agcauuagcg ugcgggccca ggaccgcuac uauagcucau cuuggagcga augggcaucu     1020

gugcccugca guggcggagg gggcggaggg agcagagcug ugccuggggg cagcagcccu     1080

gccuggacuc agugccagca gcuuucacag aagcucugca cacuggccug gagugcacau     1140

ccacuagugg gacacaugga ucuaagagaa gagggagaug aagagacuac aaaugauguu     1200

ccccauaucc aguguggaga uggcugugac ccccaaggac ucagggacaa cagucaguuc     1260

ugcuugcaaa ggauccacca gggucugauc uuuuaugaga agcugcuagg aucggauauu     1320

uucacagggg agccuucucu gcucccugau agcccugugg gccagcuuca ugccucccua     1380

cugggccuca gccaacuccu gcagccugag ggucaccacu gggagacuca gcagauucca     1440

agccucaguc ccagccagcc auggcagcgu cuccuucucc gcuucaagau ccuucgcagc     1500

cuccaggccu uuguggcugu agccgcccgg gucuuugccc auggagcagc aacccugagu     1560

cccugauaau aggcuggagc cucgguggcc augcuucuug ccccuugggc cuccccccag     1620

ccccuccucc ccuuccugca cccguacccc ccaaacacca uugucacacu ccaguggucu     1680

uugaauaaag ucugaguggg cggcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaucuag                                                             1809


<210>  27
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIGKV4-hIL-36gamma construct

<400>  27

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ser Met Cys Lys Pro Ile Thr Gly Thr Ile Asn Asp 
            20                  25                  30          


Leu Asn Gln Gln Val Trp Thr Leu Gln Gly Gln Asn Leu Val Ala Val 
        35                  40                  45              


Pro Arg Ser Asp Ser Val Thr Pro Val Thr Val Ala Val Ile Thr Cys 
    50                  55                  60                  


Lys Tyr Pro Glu Ala Leu Glu Gln Gly Arg Gly Asp Pro Ile Tyr Leu 
65                  70                  75                  80  


Gly Ile Gln Asn Pro Glu Met Cys Leu Tyr Cys Glu Lys Val Gly Glu 
                85                  90                  95      


Gln Pro Thr Leu Gln Leu Lys Glu Gln Lys Ile Met Asp Leu Tyr Gly 
            100                 105                 110         


Gln Pro Glu Pro Val Lys Pro Phe Leu Phe Tyr Arg Ala Lys Thr Gly 
        115                 120                 125             


Arg Thr Ser Thr Leu Glu Ser Val Ala Phe Pro Asp Trp Phe Ile Ala 
    130                 135                 140                 


Ser Ser Lys Arg Asp Gln Pro Ile Ile Leu Thr Ser Glu Leu Gly Lys 
145                 150                 155                 160 


Ser Tyr Asn Thr Ala Phe Glu Leu Asn Ile Asn Asp 
                165                 170         


<210>  28
<211>  516
<212>  RNA
<213>  Homo sapiens

<400>  28
augguguugc agacccaggu cuucauuucu cuguugcucu ggaucucugg ugccuacggg       60

ucaaugugua aaccuauuac ugggacuauu aaugauuuga aucagcaagu guggacccuu      120

cagggucaga accuuguggc aguuccacga agugacagug ugaccccagu cacuguugcu      180

guuaucacau gcaaguaucc agaggcucuu gagcaaggca gaggggaucc cauuuauuug      240

ggaauccaga auccagaaau guguuuguau ugugagaagg uuggagaaca gcccacauug      300

cagcuaaaag agcagaagau cauggaucug uauggccaac ccgagcccgu gaaacccuuc      360

cuuuucuacc gugccaagac ugguaggacc uccacccuug agucuguggc cuucccggac      420

ugguucauug ccuccuccaa gagagaccag cccaucauuc ugacuucaga acuugggaag      480

ucauacaaca cugccuuuga auuaaauaua aaugac                                516


<210>  29
<211>  810
<212>  RNA
<213>  Homo sapiens

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  guanine nucleotide methylated at the 7 position

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  joined by a triphosphate linkage at their 5' positions

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2' O-methylated

<400>  29
ggggaaauaa gagagaaaag aagaguaaga agaaauauaa gagccaccau gguguugcag       60

acccaggucu ucauuucucu guugcucugg aucucuggug ccuacggguc aauguguaaa      120

ccuauuacug ggacuauuaa ugauuugaau cagcaagugu ggacccuuca gggucagaac      180

cuuguggcag uuccacgaag ugacagugug accccaguca cuguugcugu uaucacaugc      240

aaguauccag aggcucuuga gcaaggcaga ggggauccca uuuauuuggg aauccagaau      300

ccagaaaugu guuuguauug ugagaagguu ggagaacagc ccacauugca gcuaaaagag      360

cagaagauca uggaucugua uggccaaccc gagcccguga aacccuuccu uuucuaccgu      420

gccaagacug guaggaccuc cacccuugag ucuguggccu ucccggacug guucauugcc      480

uccuccaaga gagaccagcc caucauucug acuucagaac uugggaaguc auacaacacu      540

gccuuugaau uaaauauaaa ugacugauaa uaggcuggag ccucgguggc caugcuucuu      600

gccccuuggg ccucccccca gccccuccuc cccuuccugc acccguaccc cccaaacacc      660

auugucacac uccagugguc uuugaauaaa gucugagugg gcggcaaaaa aaaaaaaaaa      720

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaucuag                                       810


<210>  30

<400>  30
000         

<210>  31

<400>  31
000

<210>  32

<400>  32
000

<210>  33

<400>  33
000

<210>  34

<400>  34
000

<210>  35

<400>  35
000

<210>  36

<400>  36
000

<210>  37

<400>  37
000

<210>  38

<400>  38
000

<210>  39

<400>  39
000

<210>  40

<400>  40
000

<210>  41

<400>  41
000

<210>  42

<400>  42
000

<210>  43

<400>  43
000

<210>  44

<400>  44
000

<210>  45

<400>  45
000

<210>  46

<400>  46
000

<210>  47

<400>  47
000

<210>  48

<400>  48
000

<210>  49

<400>  49
000

<210>  50

<400>  50
000

<210>  51

<400>  51
000

<210>  52

<400>  52
000

<210>  53

<400>  53
000

<210>  54

<400>  54
000

<210>  55

<400>  55
000

<210>  56

<400>  56
000

<210>  57

<400>  57
000

<210>  58

<400>  58
000

<210>  59

<400>  59
000

<210>  60

<400>  60
000

<210>  61

<400>  61
000

<210>  62

<400>  62
000

<210>  63

<400>  63
000

<210>  64

<400>  64
000

<210>  65

<400>  65
000

<210>  66

<400>  66
000

<210>  67

<400>  67
000

<210>  68

<400>  68
000

<210>  69

<400>  69
000

<210>  70

<400>  70
000

<210>  71

<400>  71
000

<210>  72

<400>  72
000

<210>  73
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  73
aacgccauua ucacacuaaa ua                                                22


<210>  74

<400>  74
000

<210>  75

<400>  75
000

<210>  76

<400>  76
000

<210>  77

<400>  77
000

<210>  78

<400>  78
000

<210>  79

<400>  79
000

<210>  80

<400>  80
000

<210>  81

<400>  81
000

<210>  82
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  82
uggaguguga caaugguguu ug                                                22


