                         SEQUENCE LISTING

<110>  23andMe, Inc.
       CHEN, Yu
       CHUNG, Wei-Jen
       FENAUX, Jill
       FUH-KELLY, Germaine
       HUANG, Yao-Ming
       KARRER, Erik Edward
       LAY, Cecilia
       PITTS, Steven J.
       SCHARF, Louise
 
<120>  ANTI-CD200R1 ANTIBODIES AND METHODS OF USE THEREOF

<130>  09402.007PV1

<160>  97    

<170>  PatentIn version 3.5

<210>  1
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Ala Gln Pro Asn Asn Ser Leu Met Leu Gln Thr Ser Lys Glu Asn 
1               5                   10                  15      


His Ala Leu Ala Ser Ser Ser Leu Cys Met Asp Glu Lys Gln Ile Thr 
            20                  25                  30          


Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser Trp Pro Val 
        35                  40                  45              


Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile Ala Leu Arg 
    50                  55                  60                  


Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser 
65                  70                  75                  80  


Cys Thr Lys Ala Tyr Arg Lys Glu Thr Asn Glu Thr Lys Glu Thr Asn 
                85                  90                  95      


Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp Gln Asn Ser 
            100                 105                 110         


Asp Leu Gln Ile Arg Pro Val Ala Ile Thr His Asp Gly Tyr Tyr Arg 
        115                 120                 125             


Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly Tyr His Leu 
    130                 135                 140                 


Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Gln Asn Arg Asn Arg 
145                 150                 155                 160 


Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala Gln Ile Ser 
                165                 170                 175     


Trp Ile Pro Glu Gly Asp Cys Ala Thr Lys Gln Glu Tyr Trp Ser Asn 
            180                 185                 190         


Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Val His Asn Val 
        195                 200                 205             


Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn Lys Ser Leu 
    210                 215                 220                 


Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser Ala Lys Leu 
225                 230                 235                 240 


<210>  2
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Ala Gln Pro Asn Asn Ser Leu Met Leu Gln Thr Ser Lys Glu Asn 
1               5                   10                  15      


His Ala Leu Ala Ser Ser Ser Leu Cys Met Asp Glu Lys Gln Ile Thr 
            20                  25                  30          


Gln Asn Tyr Ser Lys Val Leu Ala Glu Val Asn Thr Ser Trp Pro Val 
        35                  40                  45              


Lys Met Ala Thr Asn Ala Val Leu Cys Cys Pro Pro Ile Ala Leu Arg 
    50                  55                  60                  


Asn Leu Ile Ile Ile Thr Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser 
65                  70                  75                  80  


Cys Thr Lys Ala Tyr Lys Lys Glu Thr Asn Glu Thr Lys Glu Thr Asn 
                85                  90                  95      


Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Arg Pro Asp Gln Asn Ser 
            100                 105                 110         


Asp Leu Gln Ile Arg Thr Val Ala Ile Thr His Asp Gly Tyr Tyr Arg 
        115                 120                 125             


Cys Ile Met Val Thr Pro Asp Gly Asn Phe His Arg Gly Tyr His Leu 
    130                 135                 140                 


Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Gln Asn Arg Asn Arg 
145                 150                 155                 160 


Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala His Ile Ser 
                165                 170                 175     


Trp Ile Pro Glu Gly Asp Cys Ala Thr Lys Gln Glu Tyr Trp Ser Asn 
            180                 185                 190         


Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Val His Asn Val 
        195                 200                 205             


Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn Lys Ser Leu 
    210                 215                 220                 


Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser Ala Lys Leu 
225                 230                 235                 240 


<210>  3
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu 
1               5                   10                  15      


Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys 
            20                  25                  30          


Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile 
        35                  40                  45              


Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Arg Lys Glu Thr 
    50                  55                  60                  


Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val 
65                  70                  75                  80  


Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Pro Val Ala Ile 
                85                  90                  95      


Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn 
            100                 105                 110         


Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr 
        115                 120                 125             


Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly 
    130                 135                 140                 


Lys Pro Ala Ala Gln Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr 
145                 150                 155                 160 


Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys 
                165                 170                 175     


His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val Ser His 
            180                 185                 190         


Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly 
        195                 200                 205             


Ala Lys Lys Ser Ala Lys Leu 
    210                 215 


<210>  4
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Glu Lys Gln Ile Thr Gln Asn Tyr Ser Lys Val Leu Ala Glu 
1               5                   10                  15      


Val Asn Thr Ser Trp Pro Val Lys Met Ala Thr Asn Ala Val Leu Cys 
            20                  25                  30          


Cys Pro Pro Ile Ala Leu Arg Asn Leu Ile Ile Ile Thr Trp Glu Ile 
        35                  40                  45              


Ile Leu Arg Gly Gln Pro Ser Cys Thr Lys Ala Tyr Lys Lys Glu Thr 
    50                  55                  60                  


Asn Glu Thr Lys Glu Thr Asn Cys Thr Asp Glu Arg Ile Thr Trp Val 
65                  70                  75                  80  


Ser Arg Pro Asp Gln Asn Ser Asp Leu Gln Ile Arg Thr Val Ala Ile 
                85                  90                  95      


Thr His Asp Gly Tyr Tyr Arg Cys Ile Met Val Thr Pro Asp Gly Asn 
            100                 105                 110         


Phe His Arg Gly Tyr His Leu Gln Val Leu Val Thr Pro Glu Val Thr 
        115                 120                 125             


Leu Phe Gln Asn Arg Asn Arg Thr Ala Val Cys Lys Ala Val Ala Gly 
    130                 135                 140                 


Lys Pro Ala Ala His Ile Ser Trp Ile Pro Glu Gly Asp Cys Ala Thr 
145                 150                 155                 160 


Lys Gln Glu Tyr Trp Ser Asn Gly Thr Val Thr Val Lys Ser Thr Cys 
                165                 170                 175     


His Trp Glu Val His Asn Val Ser Thr Val Thr Cys His Val Ser His 
            180                 185                 190         


Leu Thr Gly Asn Lys Ser Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly 
        195                 200                 205             


Ala Lys Lys Ser Ala Lys Leu 
    210                 215 


<210>  5
<211>  241
<212>  PRT
<213>  Macaca fascicularis

<400>  5

Ala Ala Gln Ser Asn Asn Ser Leu Met Leu Gln Thr Ser Lys Glu Asn 
1               5                   10                  15      


His Thr Leu Ala Ser Asn Ser Leu Cys Met Asp Glu Lys Gln Ile Thr 
            20                  25                  30          


Gln Asn His Ser Lys Val Leu Ala Glu Val Asn Ile Ser Trp Pro Val 
        35                  40                  45              


Gln Met Ala Arg Asn Ala Val Leu Cys Cys Pro Pro Ile Glu Phe Arg 
    50                  55                  60                  


Asn Leu Ile Val Ile Thr Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser 
65                  70                  75                  80  


Cys Thr Lys Thr Tyr Arg Lys Asp Thr Asn Glu Thr Lys Glu Thr Asn 
                85                  90                  95      


Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Thr Pro Asp Gln Asn Ser 
            100                 105                 110         


Asp Leu Gln Ile His Pro Val Ala Ile Thr His Asp Gly Tyr Tyr Arg 
        115                 120                 125             


Cys Ile Met Ala Thr Pro Asp Gly Asn Phe His Arg Gly Tyr His Leu 
    130                 135                 140                 


Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Glu Ser Arg Asn Arg 
145                 150                 155                 160 


Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala Gln Ile Ser 
                165                 170                 175     


Trp Ile Pro Ala Gly Asp Cys Ala Pro Thr Glu Gln Glu Tyr Trp Gly 
            180                 185                 190         


Asn Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Gly His Asn 
        195                 200                 205             


Val Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn Lys Ser 
    210                 215                 220                 


Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser Ala Lys 
225                 230                 235                 240 


Leu 
    


<210>  6
<211>  241
<212>  PRT
<213>  Macaca mulatta

<400>  6

Ala Ala Gln Ser Asn Asn Ser Leu Met Leu Gln Thr Ser Lys Glu Asn 
1               5                   10                  15      


His Thr Leu Ala Ser Asn Ser Leu Cys Met Asp Glu Lys Gln Ile Thr 
            20                  25                  30          


Gln Asn His Ser Lys Val Leu Ala Glu Val Asn Ile Ser Trp Pro Val 
        35                  40                  45              


Gln Met Ala Arg Asn Ala Val Leu Cys Cys Pro Pro Ile Glu Phe Arg 
    50                  55                  60                  


Asn Leu Ile Val Ile Thr Trp Glu Ile Ile Leu Arg Gly Gln Pro Ser 
65                  70                  75                  80  


Cys Thr Lys Ser Tyr Arg Lys Glu Thr Asn Glu Thr Lys Glu Thr Asn 
                85                  90                  95      


Cys Thr Asp Glu Arg Ile Thr Trp Val Ser Thr Pro Asp Gln Asn Ser 
            100                 105                 110         


Asp Leu Gln Ile Tyr Pro Val Ala Ile Thr His Asp Gly Tyr Tyr Arg 
        115                 120                 125             


Cys Ile Met Ala Thr Pro Asp Gly Asn Phe His Arg Gly Tyr His Leu 
    130                 135                 140                 


Gln Val Leu Val Thr Pro Glu Val Thr Leu Phe Glu Ser Arg Asn Arg 
145                 150                 155                 160 


Thr Ala Val Cys Lys Ala Val Ala Gly Lys Pro Ala Ala Gln Ile Ser 
                165                 170                 175     


Trp Ile Pro Ala Gly Asp Cys Ala Pro Thr Glu Gln Glu Tyr Trp Gly 
            180                 185                 190         


Asn Gly Thr Val Thr Val Lys Ser Thr Cys His Trp Glu Gly His Asn 
        195                 200                 205             


Val Ser Thr Val Thr Cys His Val Ser His Leu Thr Gly Asn Lys Ser 
    210                 215                 220                 


Leu Tyr Ile Glu Leu Leu Pro Val Pro Gly Ala Lys Lys Ser Ala Lys 
225                 230                 235                 240 


Leu 
    


<210>  7
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Arg Leu Val Ile Arg Met Pro Phe Ser His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Val Met Ala Ala Val Val Leu Cys Thr Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Lys Cys Ser Leu Gln Asn Ala Gln Glu Ala Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Ser Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Phe 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Phe Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Val Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Ile Glu Asn Ser Thr Val Thr Leu Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Ile Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Val Asn Lys Gly 
225                 230         


<210>  8
<211>  232
<212>  PRT
<213>  Macaca fascicularis

<400>  8

Met Glu Arg Leu Val Ile Arg Met Pro Phe Cys His Leu Ser Thr Tyr 
1               5                   10                  15      


Ser Leu Val Trp Gly Met Ala Ala Val Val Leu Cys Ala Ala Gln Val 
            20                  25                  30          


Gln Val Val Thr Gln Asp Glu Arg Glu Gln Leu Tyr Thr Pro Ala Ser 
        35                  40                  45              


Leu Arg Cys Ser Leu Gln Asn Ala Gln Glu Val Leu Ile Val Thr Trp 
    50                  55                  60                  


Gln Lys Lys Lys Ala Val Ser Pro Glu Asn Met Val Thr Phe Ser Glu 
65                  70                  75                  80  


Asn His Gly Val Val Ile Gln Pro Ala Tyr Lys Asp Lys Ile Asn Ile 
                85                  90                  95      


Thr Gln Leu Gly Leu Gln Asn Thr Thr Ile Thr Phe Trp Asn Ile Thr 
            100                 105                 110         


Leu Glu Asp Glu Gly Cys Tyr Met Cys Leu Phe Asn Thr Phe Gly Ser 
        115                 120                 125             


Gly Lys Ile Ser Gly Thr Ala Cys Leu Thr Val Tyr Val Gln Pro Ile 
    130                 135                 140                 


Val Ser Leu His Tyr Lys Tyr Ser Glu Asp His Leu Asn Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Thr Ala Arg Pro Ala Pro Met Ile Phe Trp Lys Val Pro Arg 
                165                 170                 175     


Ser Gly Phe Glu Asn Ser Thr Val Thr Gln Ser His Pro Asn Gly Thr 
            180                 185                 190         


Thr Ser Val Thr Ser Ile Leu His Val Lys Asp Pro Lys Asn Gln Val 
        195                 200                 205             


Gly Lys Glu Val Ile Cys Gln Val Leu His Leu Gly Thr Val Thr Asp 
    210                 215                 220                 


Phe Lys Gln Thr Phe Asp Lys Gly 
225                 230         


<210>  9
<211>  228
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  9

Gly Gly Ser Gly Ser Gly Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            100                 105                 110         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Pro Gly 
225             


<210>  10
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  10

Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Met Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Ser 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Ala Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Leu Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys His Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys 
            100                 105                 110     


<210>  11
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  11

Arg Ala Ser Glu Ser Val Asp Tyr Ser Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  12
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  12

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  13
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  13

His Gln Ser Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  14
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  14

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Met Trp Ala Gly Gly Gly Thr Asn Tyr Asn Ser Val Phe Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg Pro Leu Thr Gly Val Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  15
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  15

Thr Asn Tyr Ala Val Ser 
1               5       


<210>  16
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  16

Val Met Trp Ala Gly Gly Gly Thr Asn Tyr Asn Ser 
1               5                   10          


<210>  17
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  17

Ala Arg Glu Arg Pro Leu Thr Gly Val Met Asp Tyr 
1               5                   10          


<210>  18
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  18

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Thr Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Phe Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  19
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  19

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  20
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  20

Leu Thr Ser Lys Leu Ala Ser 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  21

Gln Gln Trp Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  22
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  22

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Asp Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Arg Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Val Glu Gly Arg Thr Gly Thr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  23
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  23

Lys Asp Asp Tyr Met His 
1               5       


<210>  24
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  24

Arg Ile Asp Pro Ala Asn Asp Asn Thr Lys Tyr Ala Pro 
1               5                   10              


<210>  25
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  25

Thr Arg Val Glu Gly Arg Thr Gly Thr Tyr Phe Asp Tyr 
1               5                   10              


<210>  26
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  26

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Phe Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Tyr Asn Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  27

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  28
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  28

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  29

Gln Gln Tyr Asn Glu Tyr Pro Trp Thr 
1               5                   


<210>  30
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  30

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Asp 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asn Gly Asn Thr Lys Tyr Gly Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gln Leu Gly Leu Arg Arg Val Trp Tyr Ala Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  31
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  31

Lys Asp Asp Tyr Met His 
1               5       


<210>  32
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  32

Arg Ile Asp Pro Glu Asn Gly Asn Thr Lys Tyr Gly Pro 
1               5                   10              


<210>  33
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  33

Thr Arg Gln Leu Gly Leu Arg Arg Val Trp Tyr Ala Leu Asp Tyr 
1               5                   10                  15  


<210>  34
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  34

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Val Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Tyr Asn Glu Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  35
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  35

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  36
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  36

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  37
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  37

Gln Gln Tyr Asn Glu Tyr Pro Trp Thr 
1               5                   


<210>  38
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  38

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Phe Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Thr Ser Gly Phe Tyr Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Arg Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Gly Leu Arg Arg Thr Trp Tyr Ser Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  39
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  39

Lys Asp Asp Tyr Ile His 
1               5       


<210>  40
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  40

Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro 
1               5                   10              


<210>  41
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  41

Ala Arg Gln Leu Gly Leu Arg Arg Thr Trp Tyr Ser Leu Asp Tyr 
1               5                   10                  15  


<210>  42
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  42

Asp Val Gln Met Ile Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Met Thr Cys Gln Ala Ser His Thr Ile Asn Leu Asn 
            20                  25                  30          


Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly 
        35                  40                  45              


Thr Ser Asn Leu Glu Asp Gly Val Pro Pro Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Asp Glu Asp 
65                  70                  75                  80  


Met Ala Thr Tyr Phe Cys Leu Gln His Thr Tyr Leu Pro Trp Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  43
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  43

Gln Ala Ser His Thr Ile Asn Leu Asn 
1               5                   


<210>  44
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  44

Gly Thr Ser Asn Leu Glu Asp 
1               5           


<210>  45
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  45

Leu Gln His Thr Tyr Leu Pro Trp Thr 
1               5                   


<210>  46
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  46

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Phe Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Thr Thr Ser Gly Phe Tyr Ile Lys Asp Asp 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gln Leu Gly Leu Arg Arg Thr Trp Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  47
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  47

Lys Asp Asp Tyr Ile His 
1               5       


<210>  48
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  48

Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Ala Pro 
1               5                   10              


<210>  49
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  49

Thr Arg Gln Leu Gly Leu Arg Arg Thr Trp Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  50
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  50

Asp Val Gln Met Ile Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Lys Val Thr Met Thr Cys Gln Ala Ser His Thr Ile Asn Leu Asn 
            20                  25                  30          


Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly 
        35                  40                  45              


Thr Ser Asn Leu Glu Asp Gly Val Pro Pro Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Asp Glu Asp 
65                  70                  75                  80  


Met Ala Thr Tyr Phe Cys Leu Gln His Thr Tyr Leu Pro Trp Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105 


<210>  51
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  51

Gln Ala Ser His Thr Ile Asn Leu Asn 
1               5                   


<210>  52
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  52

Gly Thr Ser Asn Leu Glu Asp 
1               5           


<210>  53
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  53

Leu Gln His Thr Tyr Leu Pro Trp Thr 
1               5                   


<210>  54
<211>  114
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  54

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ser Pro Gly Gln Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Ala Val Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala 
        


<210>  55
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  55

Thr Ser Tyr Trp Met His 
1               5       


<210>  56
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  56

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Asn Tyr Asn Gln 
1               5                   10              


<210>  57
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  57

Thr Thr Ala Val Gly Ser Tyr 
1               5           


<210>  58
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  58

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Val 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Asn Arg 
                85                  90                  95      


Glu Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110 


<210>  59
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  59

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  60
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  60

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  61
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  61

Gln His Asn Arg Glu Leu Leu Thr 
1               5               


<210>  62
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  62

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met Phe Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Tyr Gly Ser Arg Phe Val Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  63
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  63

Thr Ser Tyr Val Met Phe 
1               5       


<210>  64
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  64

Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Lys Tyr Asn Glu 
1               5                   10              


<210>  65
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  65

Ala Arg Glu Asp Tyr Tyr Gly Ser Arg Phe Val Tyr Trp 
1               5                   10              


<210>  66
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  66

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Tyr Ser 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  67
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  67

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Met Trp Ala Gly Gly Gly Thr Asn Tyr Asn Ser Val Phe Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg Pro Leu Thr Gly Val Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  68
<211>  237
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  68

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val 
        35                  40                  45              


Asp Tyr Ser Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His 
            100                 105                 110         


Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  69
<211>  465
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  69

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Ala Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Met Trp Ala Gly Gly Gly Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Val Phe Lys Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
                85                  90                  95      


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Arg Pro Leu Thr Gly Val Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly 
465 


<210>  70
<211>  466
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  70

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Ala Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Met Trp Ala Gly Gly Gly Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Val Phe Lys Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
                85                  90                  95      


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Arg Pro Leu Thr Gly Val Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  71
<211>  237
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  71

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val 
            20                  25                  30          


Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val 
        35                  40                  45              


Asp Tyr Ser Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His 
            100                 105                 110         


Gln Ser Asn Trp Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  72
<211>  466
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  72

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Arg Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Met Tyr Ala Gly Gly Gly Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Val Phe Lys Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
                85                  90                  95      


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Arg Pro Leu Thr Gly Val Met Asp Asn Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  73
<211>  466
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  73

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Trp Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Thr Met Trp Ala Gly Gly Gly Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Val Phe Lys Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
                85                  90                  95      


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Arg Pro Leu Thr Gly Pro Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  74
<211>  236
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  74

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val 
        35                  40                  45              


Ser Thr Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


His Asn Arg Glu Leu Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  75
<211>  467
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  75

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met Phe Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Tyr Asn Asp Asp Thr Lys Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Arg Ala Thr Leu Thr Ser Asp Lys Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Asp Tyr Tyr Gly Ser Arg Phe Val Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly 
465         


<210>  76
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  76

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Tyr Ser 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ser Asn 
                85                  90                  95      


Trp Asp Pro Pro Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  77
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  77

Arg Ala Ser Glu Ser Val Asp Tyr Ser Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  78
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  78

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  79
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  79

His Gln Ser Asn Trp Asp Pro Pro Thr 
1               5                   


<210>  80
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  80

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Arg Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Met Tyr Ala Gly Gly Gly Thr Asn Tyr Asn Ser Val Phe Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg Pro Leu Thr Gly Val Met Asp Asn Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  81
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  81

Thr Asn Tyr Arg Val Ser 
1               5       


<210>  82
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  82

Val Met Tyr Ala Gly Gly Gly Thr Asn Tyr Asn Ser 
1               5                   10          


<210>  83
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  83

Ala Arg Glu Arg Pro Leu Thr Gly Val Met Asp Asn 
1               5                   10          


<210>  84
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  84

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Trp Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Thr Met Trp Ala Gly Gly Gly Thr Asn Tyr Asn Ser Val Phe Lys 
    50                  55                  60                  


Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Arg Pro Leu Thr Gly Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  85
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  85

Thr Asn Tyr Trp Val Ser 
1               5       


<210>  86
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  86

Thr Met Trp Ala Gly Gly Gly Thr Asn Tyr Asn Ser 
1               5                   10          


<210>  87
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  87

Ala Arg Glu Arg Pro Leu Thr Gly Pro Met Asp Tyr 
1               5                   10          


<210>  88
<211>  465
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  88

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Arg Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Met Tyr Ala Gly Gly Gly Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Val Phe Lys Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
                85                  90                  95      


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Arg Pro Leu Thr Gly Val Met Asp Asn Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly 
465 


<210>  89
<211>  465
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  89

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asn Tyr Trp Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Thr Met Trp Ala Gly Gly Gly Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Val Phe Lys Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Asn Gln 
                85                  90                  95      


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Glu Arg Pro Leu Thr Gly Pro Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gly Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly 
465 


<210>  90
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  90

Gly Gly Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
1               5                   10                  15      


Trp His Glu Gly Ser Gly Gly His His His His His His His His 
            20                  25                  30      


<210>  91
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  91

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  92
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  92
tcttgtccac cttggtgctg ctggccgg                                          28


<210>  93
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  93
tttgtccacc gtggtgctgc tggctggt                                          28


<210>  94
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  94
gatcagtcca actgttcagg acgcc                                             25


<210>  95
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  95
acactcagca cgggacaaac tcttctccac agt                                    33


<210>  96
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  96
acactctgca ggagacagac tcttttccac agt                                    33


<210>  97
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  97
acactcagca cgggacaaac tcttctccac atg                                    33


