                         SEQUENCE LISTING

<110>  AVANTGEN, INC.
 
<120>  SARS-COV-2 BINDING AGENTS AND USES THEREOF

<130>  13366-010-228

<140>
<141>

<150>  US 63/081,893
<151>  2020-09-22

<150>  US 63/031,565
<151>  2020-05-28

<150>  US 63/031,564
<151>  2020-05-28

<150>  US 63/031,560
<151>  2020-05-28

<160>  170   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-F11, AvGn-B-G4, AvGn-B-A1 VH 
       CDR1 (Exemplary, AbM)

<400>  1

Gly Gly Thr Phe Ser Ser Tyr Gly Ile Ser 
1               5                   10  


<210>  2
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B) VH CDR2 (Exemplary, Kabat)

<400>  2

Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-H2, AvGn-B-F11, AvGn-B-H1, 
       AvGn-B-G4, AvGn-B-F2, AvGn-B-G2, AvGn-B-A1 VH CDR3 (Exemplary, 
       Kabat, AbM)

<400>  3

Tyr Tyr Val Gly Trp Gly Trp Phe Asp Val 
1               5                   10  


<210>  4
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-F2, AvGn-B-A1 VL CDR1 
       (Exemplary, Kabat, AbM)

<400>  4

Arg Ala Ser Gln Ser Val Arg Ser Thr Tyr Leu Ala 
1               5                   10          


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B) VL CDR2 (Exemplary, Kabat, AbM)

<400>  5

Ser Ala Ser Ser Arg Ala Thr 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-F11, AvGn-B-H1, AvGn-B-F2, 
       AvGn-B-G2 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  6

Gln Gln Tyr Ala Ser Ala Pro Tyr Thr 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-F11, AvGn-B-G4, AvGn-B-A1 VH 
       CDR1 (IMGT)

<400>  7

Gly Gly Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B) VH CDR2 (IMGT)

<400>  8

Ile Ile Pro Ile Phe Asp Thr Ala 
1               5               


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-H2, AvGn-B-F11, AvGn-B-H1, 
       AvGn-B-G4, AvGn-B-F2, AvGn-B-G2, AvGn-B-A1 VH CDR3 (IMGT)

<400>  9

Ala Arg Tyr Tyr Val Gly Trp Gly Trp Phe Asp Val 
1               5                   10          


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-F2, AvGn-B-A1 VL CDR1 (IMGT)

<400>  10

Gln Ser Val Arg Ser Thr Tyr 
1               5           


<210>  11
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B) VL CDR2 (IMGT, Chothia)

<400>  11

Ser Ala Ser 
1           


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-H2, AvGn-B-F11, AvGn-B-H1, 
       AvGn-B-G4, AvGn-B-A1 VH CDR1 (Kabat)

<400>  12

Ser Tyr Gly Ile Ser 
1               5   


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-F11, AvGn-B-G4, AvGn-B-A1 VH 
       CDR1 (Chothia)

<400>  13

Gly Gly Thr Phe Ser Ser Tyr 
1               5           


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-H2, AvGn-B-F11, AvGn-B-H1, 
       AvGn-B-G4, AvGn-B-F2, AvGn-B-G2, AvGn-B-A1 VH CDR2 (Chothia)

<400>  14

Pro Ile Phe Asp 
1               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-H2, AvGn-B-F11, AvGn-B-H1, 
       AvGn-B-G4, AvGn-B-F2, AvGn-B-G2, AvGn-B-A1 VH CDR3 (Chothia)

<400>  15

Tyr Val Gly Trp Gly Trp Phe Asp 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-F2, AvGn-B-A1 VL CDR1 (Chothia)

<400>  16

Ser Gln Ser Val Arg Ser Thr Tyr 
1               5               


<210>  17
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-F11, AvGn-B-H1, AvGn-B-F2, 
       AvGn-B-G2 VL CDR3 (Chothia)

<400>  17

Tyr Ala Ser Ala Pro Tyr 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-H2, AvGn-B-F11, AvGn-B-H1, 
       AvGn-B-G4, AvGn-B-A1 VH CDR1 (Contact)

<400>  18

Ser Ser Tyr Gly Ile Ser 
1               5       


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B) VH CDR2 (Contact)

<400>  19

Trp Met Gly Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn 
1               5                   10              


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-H2, AvGn-B-F11, AvGn-B-H1, 
       AvGn-B-G4, AvGn-B-F2, AvGn-B-G2, AvGn-B-A1 VH CDR3 (Contact)

<400>  20

Ala Arg Tyr Tyr Val Gly Trp Gly Trp Phe Asp 
1               5                   10      


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-F2, AvGn-B-A1 VL CDR1 (Contact)

<400>  21

Arg Ser Thr Tyr Leu Ala Trp Tyr 
1               5               


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B) VL CDR2 (Contact)

<400>  22

Leu Leu Ile Tyr Ser Ala Ser Ser Arg Ala 
1               5                   10  


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B), AvGn-B-F11, AvGn-B-H1, AvGn-B-F2, 
       AvGn-B-G2 VL CDR3 (Contact)

<400>  23

Gln Gln Tyr Ala Ser Ala Pro Tyr 
1               5               


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B) VH CDR2 (AbM)

<400>  24

Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn 
1               5                   10  


<210>  25
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B) VH Sequence

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Gly Trp Gly Trp Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  26
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone B (AvGn-B) VL Sequence

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Ser Ala Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  27
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike protein sequence (UniProt P0DTC2) receptor 
       binding domain (RBD) (residues Arg319 to Asn532)

<400>  27

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn 
    210                 


<210>  28
<211>  670
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike protein sequence (UniProt P0DTC2) S1 domain; 
       residues Gln14 to Arg683

<400>  28

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg 
            660                 665                 670 


<210>  29
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-1 spike protein sequence (UniProt P59594) receptor 
       binding domain (RBD) (residues Arg306-Phe527)

<400>  29

Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     


Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         


Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             


Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe 
    210                 215                 220         


<210>  30
<211>  723
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human ACE2  sequence (UniProt Q9BYF1) (residues  Gln18 -Ser740)

<400>  30

Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      


His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          


Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              


Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  


Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  


Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      


Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         


Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             


Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 


Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 


Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     


Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         


Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             


Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 


Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 


Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     


Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         


Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             


Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 


Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 


Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     


Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         


Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             


Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 


Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 


Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     


Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         


Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             


Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 


Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 


Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     


Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         


Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             


Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 


Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 


Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     


Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         


Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             


Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 


Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 


Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     


Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         


Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             


Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 


Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 


Pro Val Ser 
            


<210>  31
<211>  1261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 spike protein sequence (UniProt P0DTC2) residues 13 to
       1273

<400>  31

Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
1               5                   10                  15      


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
            20                  25                  30          


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
        35                  40                  45              


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
    50                  55                  60                  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
65                  70                  75                  80  


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
                85                  90                  95      


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
            100                 105                 110         


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
        115                 120                 125             


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
    130                 135                 140                 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
145                 150                 155                 160 


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
                165                 170                 175     


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
            180                 185                 190         


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
        195                 200                 205             


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
    210                 215                 220                 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
225                 230                 235                 240 


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
                245                 250                 255     


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
            260                 265                 270         


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
        275                 280                 285             


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
    290                 295                 300                 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
305                 310                 315                 320 


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
                325                 330                 335     


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
            340                 345                 350         


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        355                 360                 365             


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    370                 375                 380                 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                405                 410                 415     


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            420                 425                 430         


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
        435                 440                 445             


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
    450                 455                 460                 


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
465                 470                 475                 480 


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
                485                 490                 495     


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
            500                 505                 510         


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
        515                 520                 525             


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
    530                 535                 540                 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
545                 550                 555                 560 


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
                565                 570                 575     


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
            580                 585                 590         


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
        595                 600                 605             


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
    610                 615                 620                 


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
625                 630                 635                 640 


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
                645                 650                 655     


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala 
            660                 665                 670         


Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
        675                 680                 685             


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
    690                 695                 700                 


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
705                 710                 715                 720 


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
                725                 730                 735     


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
            740                 745                 750         


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
        755                 760                 765             


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
    770                 775                 780                 


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
785                 790                 795                 800 


Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
                805                 810                 815     


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
            820                 825                 830         


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
        835                 840                 845             


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
    850                 855                 860                 


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
865                 870                 875                 880 


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
                885                 890                 895     


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
            900                 905                 910         


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
        915                 920                 925             


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
    930                 935                 940                 


Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala 
945                 950                 955                 960 


Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu 
                965                 970                 975     


Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu 
            980                 985                 990         


Gln Thr Tyr Val Thr Gln Gln Leu  Ile Arg Ala Ala Glu  Ile Arg Ala 
        995                 1000                 1005             


Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly 
    1010                 1015                 1020             


Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met 
    1025                 1030                 1035             


Ser Phe  Pro Gln Ser Ala Pro  His Gly Val Val Phe  Leu His Val 
    1040                 1045                 1050             


Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe Thr Thr  Ala Pro Ala 
    1055                 1060                 1065             


Ile Cys  His Asp Gly Lys Ala  His Phe Pro Arg Glu  Gly Val Phe 
    1070                 1075                 1080             


Val Ser  Asn Gly Thr His Trp  Phe Val Thr Gln Arg  Asn Phe Tyr 
    1085                 1090                 1095             


Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn 
    1100                 1105                 1110             


Cys Asp  Val Val Ile Gly Ile  Val Asn Asn Thr Val  Tyr Asp Pro 
    1115                 1120                 1125             


Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr 
    1130                 1135                 1140             


Phe Lys  Asn His Thr Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser 
    1145                 1150                 1155             


Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg 
    1160                 1165                 1170             


Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu 
    1175                 1180                 1185             


Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr 
    1190                 1195                 1200             


Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile Ala Ile  Val Met Val 
    1205                 1210                 1215             


Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys 
    1220                 1225                 1230             


Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp 
    1235                 1240                 1245             


Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu His Tyr  Thr 
    1250                 1255                 1260     


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VH CDR1 (Exemplary, AbM)

<400>  32

Gly Gly Thr Leu Ser Ser Tyr Gly Ile Ser 
1               5                   10  


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VH CDR2 (Exemplary, Kabat)

<400>  33

Gly Ile Ile Pro Ile Phe Asp Thr Val Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VL CDR1 (Exemplary, Kabat, AbM)

<400>  34

Arg Ala Ser Gln Ser Val Arg Asp Thr Tyr Leu Ala 
1               5                   10          


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2, AvGn-B-F11, AvGn-B-H1, AvGn-B-F2, AvGn-B-A1 VL CDR2 
       (Exemplary, Kabat, AbM)

<400>  35

Asp Ala Ser Ser Arg Ala Thr 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  36

Gln Gln Tyr Ser Ser Ala Pro Tyr Thr 
1               5                   


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VH CDR1 (IMGT)

<400>  37

Gly Gly Thr Leu Ser Ser Tyr Gly 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2, AvGn-B-F11 VH CDR2 (IMGT)

<400>  38

Ile Ile Pro Ile Phe Asp Thr Val 
1               5               


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VL CDR1 (IMGT)

<400>  39

Gln Ser Val Arg Asp Thr Tyr 
1               5           


<210>  40
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2, AvGn-B-F11, AvGn-B-H1, AvGn-B-F2, AvGn-B-A1 VL CDR2 
       (IMGT, Chothia)

<400>  40

Asp Ala Ser 
1           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VH CDR1 (Chothia)

<400>  41

Gly Gly Thr Leu Ser Ser Tyr 
1               5           


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VL CDR1 (Chothia)

<400>  42

Ser Gln Ser Val Arg Asp Thr Tyr 
1               5               


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VL CDR3 (Chothia)

<400>  43

Tyr Ser Ser Ala Pro Tyr 
1               5       


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2, AvGn-B-F11 VH CDR2 (Contact)

<400>  44

Trp Met Gly Gly Ile Ile Pro Ile Phe Asp Thr Val Asn 
1               5                   10              


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VL CDR1 (Contact)

<400>  45

Arg Asp Thr Tyr Leu Ala Trp Tyr 
1               5               


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2, AvGn-B-F11, AvGn-B-H1, AvGn-B-F2, AvGn-B-A1 VL CDR2 
       (Contact)

<400>  46

Leu Leu Ile Tyr Asp Ala Ser Ser Arg Ala 
1               5                   10  


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VL CDR3 (Contact)

<400>  47

Gln Gln Tyr Ser Ser Ala Pro Tyr 
1               5               


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2, AvGn-B-F11 VH CDR2 (AbM)

<400>  48

Gly Ile Ile Pro Ile Phe Asp Thr Val Asn 
1               5                   10  


<210>  49
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VH Sequence

<400>  49

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Gly Trp Gly Trp Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  50
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H2 VL Sequence

<400>  50

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Asp Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Ser Ala Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F11 VH CDR2 (Exemplary, Kabat)

<400>  51

Gly Ile Ile Pro Ile Phe Asp Thr Val Asn Tyr Ala Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F11, AvGn-B-H1, AvGn-B-G4, AvGn-B-G2 VL CDR1 (Exemplary, 
       Kabat, AbM)

<400>  52

Arg Ala Ser Gln Ser Val Arg Gly Thr Tyr Leu Ala 
1               5                   10          


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F11, AvGn-B-H1, AvGn-B-G4, AvGn-B-G2 VL CDR1 (IMGT)

<400>  53

Gln Ser Val Arg Gly Thr Tyr 
1               5           


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F11, AvGn-B-H1, AvGn-B-G4, AvGn-B-G2 VL CDR1 (Chothia)

<400>  54

Ser Gln Ser Val Arg Gly Thr Tyr 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F11, AvGn-B-H1, AvGn-B-G4, AvGn-B-G2 VL CDR1 (Contact)

<400>  55

Arg Gly Thr Tyr Leu Ala Trp Tyr 
1               5               


<210>  56
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F11 VH Sequence

<400>  56

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Gly Trp Gly Trp Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  57
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F11, AvGn-B-H1 VL Sequence

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Gly Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Ser Ala Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H1 VH CDR1 (Exemplary, AbM)

<400>  58

Gly Gly Ser Phe Ser Ser Tyr Gly Ile Ser 
1               5                   10  


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H1 VH CDR2 (Exemplary, Kabat)

<400>  59

Gly Ile Ile Pro Ile Phe Asp Thr Leu Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H1 VH CDR1 (IMGT)

<400>  60

Gly Gly Ser Phe Ser Ser Tyr Gly 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H1 VH CDR2 (IMGT)

<400>  61

Ile Ile Pro Ile Phe Asp Thr Leu 
1               5               


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H1 VH CDR1 (Chothia)

<400>  62

Gly Gly Ser Phe Ser Ser Tyr 
1               5           


<210>  63
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H1 VH CDR2 (Contact)

<400>  63

Trp Met Gly Gly Ile Ile Pro Ile Phe Asp Thr Leu Asn 
1               5                   10              


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H1 VH CDR2 (AbM)

<400>  64

Gly Ile Ile Pro Ile Phe Asp Thr Leu Asn 
1               5                   10  


<210>  65
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-H1 VH Sequence

<400>  65

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Leu Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Gly Trp Gly Trp Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4, AvGn-B-F2 VH CDR2 (Exemplary, Kabat)

<400>  66

Gly Ile Ile Pro Ile Phe Asp Thr Ile Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4 VL CDR2 (Exemplary, Kabat, AbM)

<400>  67

Ser Ala Thr Ser Arg Ala Thr 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  68

Gln Gln Tyr Ala Ser Ala Pro Phe Thr 
1               5                   


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4, AvGn-B-F2 VH CDR2 (IMGT)

<400>  69

Ile Ile Pro Ile Phe Asp Thr Ile 
1               5               


<210>  70
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4 VL CDR2 (IMGT, Chothia)

<400>  70

Ser Ala Thr 
1           


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4 VL CDR3 (Chothia)

<400>  71

Tyr Ala Ser Ala Pro Phe 
1               5       


<210>  72
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4, AvGn-B-F2 VH CDR2 (Contact)

<400>  72

Trp Met Gly Gly Ile Ile Pro Ile Phe Asp Thr Ile Asn 
1               5                   10              


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4 VL CDR2 (Contact)

<400>  73

Leu Leu Ile Tyr Ser Ala Thr Ser Arg Ala 
1               5                   10  


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4 VL CDR3 (Contact)

<400>  74

Gln Gln Tyr Ala Ser Ala Pro Phe 
1               5               


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4, AvGn-B-F2 VH CDR2 (AbM)

<400>  75

Gly Ile Ile Pro Ile Phe Asp Thr Ile Asn 
1               5                   10  


<210>  76
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4 VH Sequence

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Ile Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Gly Trp Gly Trp Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  77
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G4 VL Sequence

<400>  77

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Gly Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Thr Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Ser Ala Pro 
                85                  90                  95      


Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F2 VH CDR1 (Exemplary, AbM)

<400>  78

Gly Gly Thr Phe Ser Ser His Gly Ile Ser 
1               5                   10  


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F2 VH CDR1 (IMGT)

<400>  79

Gly Gly Thr Phe Ser Ser His Gly 
1               5               


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F2 VH CDR1 (Kabat)

<400>  80

Ser His Gly Ile Ser 
1               5   


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F2 VH CDR1 (Chothia)

<400>  81

Gly Gly Thr Phe Ser Ser His 
1               5           


<210>  82
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F2 VH CDR1 (Contact)

<400>  82

Ser Ser His Gly Ile Ser 
1               5       


<210>  83
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F2 VH Sequence

<400>  83

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser His 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Thr Ile Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Gly Trp Gly Trp Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  84
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-F2 VL Sequence

<400>  84

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Ser Ala Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VH CDR1 (Exemplary, AbM)

<400>  85

Gly Gly Thr Phe Ser Ser Ser Gly Ile Ser 
1               5                   10  


<210>  86
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VH CDR2 (Exemplary, Kabat)

<400>  86

Gly Ile Ile Pro Ile Phe Asp Arg Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VL CDR2 (Exemplary, Kabat, AbM)

<400>  87

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VH CDR1 (IMGT)

<400>  88

Gly Gly Thr Phe Ser Ser Ser Gly 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VH CDR2 (IMGT)

<400>  89

Ile Ile Pro Ile Phe Asp Arg Ala 
1               5               


<210>  90
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2, Antibody Clone F VL CDR2 (IMGT, Chothia)

<400>  90

Gly Ala Ser 
1           


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VH CDR1 (Kabat)

<400>  91

Ser Ser Gly Ile Ser 
1               5   


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VH CDR1 (Chothia)

<400>  92

Gly Gly Thr Phe Ser Ser Ser 
1               5           


<210>  93
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VH CDR1 (Contact)

<400>  93

Ser Ser Ser Gly Ile Ser 
1               5       


<210>  94
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VH CDR2 (Contact)

<400>  94

Trp Met Gly Gly Ile Ile Pro Ile Phe Asp Arg Ala Asn 
1               5                   10              


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VL CDR2 (Contact)

<400>  95

Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala 
1               5                   10  


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VH CDR2 (AbM)

<400>  96

Gly Ile Ile Pro Ile Phe Asp Arg Ala Asn 
1               5                   10  


<210>  97
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VH Sequence

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Arg Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Gly Trp Gly Trp Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  98
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-G2 VL Sequence

<400>  98

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Gly Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Ser Ala Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  99
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-A1 VH CDR2 (Exemplary, Kabat)

<400>  99

Gly Ile Ile Pro Ile Phe Asp Val Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-A1 VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  100

Gln Gln Tyr Ala Ser Leu Pro Tyr Thr 
1               5                   


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-A1 VH CDR2 (IMGT)

<400>  101

Ile Ile Pro Ile Phe Asp Val Ala 
1               5               


<210>  102
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-A1 VL CDR3 (Chothia)

<400>  102

Tyr Ala Ser Leu Pro Tyr 
1               5       


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-A1 VH CDR2 (Contact)

<400>  103

Trp Met Gly Gly Ile Ile Pro Ile Phe Asp Val Ala Asn 
1               5                   10              


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-A1 VL CDR3 (Contact)

<400>  104

Gln Gln Tyr Ala Ser Leu Pro Tyr 
1               5               


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-A1 VH CDR2 (AbM)

<400>  105

Gly Ile Ile Pro Ile Phe Asp Val Ala Asn 
1               5                   10  


<210>  106
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-A1 VH Sequence

<400>  106

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Asp Val Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Val Gly Trp Gly Trp Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  107
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AvGn-B-A1 VL Sequence

<400>  107

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ala Ser Leu Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VH CDR1


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  108

Gly Gly Xaa Xaa Ser Ser Xaa Gly Ile Ser 
1               5                   10  


<210>  109
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VH CDR2


<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  109

Gly Ile Ile Pro Ile Phe Asp Xaa Xaa Asn Tyr Ala Gln Lys Phe Xaa 
1               5                   10                  15      


Gly 
    


<210>  110
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VL CDR1


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  110

Arg Ala Ser Gln Ser Val Arg Xaa Thr Tyr Leu Ala 
1               5                   10          


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VL CDR2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  111

Xaa Ala Xaa Ser Arg Ala Thr 
1               5           


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VL CDR3


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  112

Gln Gln Tyr Xaa Ser Xaa Pro Xaa Thr 
1               5                   


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VH CDR1


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is F or L

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Y, S or H

<400>  113

Gly Gly Xaa Xaa Ser Ser Xaa Gly Ile Ser 
1               5                   10  


<210>  114
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VH CDR2


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is T, R or V

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is A, I, L or V

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is Q or R

<400>  114

Gly Ile Ile Pro Ile Phe Asp Xaa Xaa Asn Tyr Ala Gln Lys Phe Xaa 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VL CDR1


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is S, G or D

<400>  115

Arg Ala Ser Gln Ser Val Arg Xaa Thr Tyr Leu Ala 
1               5                   10          


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VL CDR2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is S, G or D

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is S or T

<400>  116

Xaa Ala Xaa Ser Arg Ala Thr 
1               5           


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VL CDR3


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is A or S

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is A or L

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is Y or F

<400>  117

Gln Gln Tyr Xaa Ser Xaa Pro Xaa Thr 
1               5                   


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR1 (Exemplary, AbM)

<400>  118

Gly Phe Thr Phe Arg Asn Tyr Ala Met Ser 
1               5                   10  


<210>  119
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR2 (Exemplary, Kabat)

<400>  119

Ala Ile Tyr Ser Ser Gly Glu Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR3 (Exemplary, Kabat, AbM)

<400>  120

Gly Asp Gly Gly Val Glu Tyr Ala Phe Asp Tyr 
1               5                   10      


<210>  121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VL CDR1 (Exemplary, Kabat, AbM)

<400>  121

Arg Ala Ser Gln Ser Ile Ser Thr Tyr Leu Asn 
1               5                   10      


<210>  122
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VL CDR2 (Exemplary, Kabat, AbM)

<400>  122

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  123
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  123

Gln Gln Ser Tyr Ser Phe Pro Pro Thr 
1               5                   


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR1 (IMGT)

<400>  124

Gly Phe Thr Phe Arg Asn Tyr Ala 
1               5               


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR2 (IMGT)

<400>  125

Ile Tyr Ser Ser Gly Glu Thr 
1               5           


<210>  126
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR3 (IMGT)

<400>  126

Ala Arg Gly Asp Gly Gly Val Glu Tyr Ala Phe Asp Tyr 
1               5                   10              


<210>  127
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VL CDR1 (IMGT)

<400>  127

Gln Ser Ile Ser Thr Tyr 
1               5       


<210>  128
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VL CDR2 (IMGT, Chothia)

<400>  128

Ala Ala Ser 
1           


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR1 (Kabat)

<400>  129

Asn Tyr Ala Met Ser 
1               5   


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR1 (Chothia)

<400>  130

Gly Phe Thr Phe Arg Asn Tyr 
1               5           


<210>  131
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR2 (Chothia)

<400>  131

Ser Ser Gly 
1           


<210>  132
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR3 (Chothia)

<400>  132

Asp Gly Gly Val Glu Tyr Ala Phe Asp 
1               5                   


<210>  133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VL CDR1 (Chothia)

<400>  133

Ser Gln Ser Ile Ser Thr Tyr 
1               5           


<210>  134
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VL CDR3 (Chothia)

<400>  134

Ser Tyr Ser Phe Pro Pro 
1               5       


<210>  135
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR1 (Contact)

<400>  135

Arg Asn Tyr Ala Met Ser 
1               5       


<210>  136
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR2 (Contact)

<400>  136

Trp Val Ser Ala Ile Tyr Ser Ser Gly Glu Thr Tyr 
1               5                   10          


<210>  137
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR3 (Contact)

<400>  137

Ala Arg Gly Asp Gly Gly Val Glu Tyr Ala Phe Asp 
1               5                   10          


<210>  138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VL CDR1 (Contact)

<400>  138

Ser Thr Tyr Leu Asn Trp Tyr 
1               5           


<210>  139
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VL CDR2 (Contact)

<400>  139

Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
1               5                   10  


<210>  140
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VL CDR3 (Contact)

<400>  140

Gln Gln Ser Tyr Ser Phe Pro Pro 
1               5               


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH CDR2 (AbM)

<400>  141

Ala Ile Tyr Ser Ser Gly Glu Thr Tyr 
1               5                   


<210>  142
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VH Sequence

<400>  142

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Tyr Ser Ser Gly Glu Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asp Gly Gly Val Glu Tyr Ala Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  143
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone C VL Sequence

<400>  143

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR1 (Exemplary, AbM)

<400>  144

Gly Gly Thr Phe Ser Asn Tyr Ala Val His 
1               5                   10  


<210>  145
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR2 (Exemplary, Kabat)

<400>  145

Arg Ile Ile Pro Ile Phe Gly Thr Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR3 (Exemplary, Kabat, AbM)

<400>  146

Gly Tyr Leu Gly Phe Ala Phe Asp Val 
1               5                   


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VL CDR1 (Exemplary, Kabat, AbM)

<400>  147

Arg Thr Ser Gln Ser Val Thr Thr Asn Leu Ala 
1               5                   10      


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VL CDR2 (Exemplary, Kabat, AbM)

<400>  148

Gly Ala Ser Thr Arg Val Thr 
1               5           


<210>  149
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VL CDR3 (Exemplary, IMGT, Kabat, AbM)

<400>  149

Gln Gln Tyr Tyr Asn Trp Pro Phe Thr 
1               5                   


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR1 (IMGT)

<400>  150

Gly Gly Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR2 (IMGT)

<400>  151

Ile Ile Pro Ile Phe Gly Thr Thr 
1               5               


<210>  152
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR3 (IMGT)

<400>  152

Ala Arg Gly Tyr Leu Gly Phe Ala Phe Asp Val 
1               5                   10      


<210>  153
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VL CDR1 (IMGT)

<400>  153

Gln Ser Val Thr Thr Asn 
1               5       


<210>  154
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR1 (Kabat)

<400>  154

Asn Tyr Ala Val His 
1               5   


<210>  155
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR1 (Chothia)

<400>  155

Gly Gly Thr Phe Ser Asn Tyr 
1               5           


<210>  156
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR2 (Chothia)

<400>  156

Pro Ile Phe Gly 
1               


<210>  157
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR3 (Chothia)

<400>  157

Tyr Leu Gly Phe Ala Phe Asp 
1               5           


<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VL CDR1 (Chothia)

<400>  158

Ser Gln Ser Val Thr Thr Asn 
1               5           


<210>  159
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VL CDR3 (Chothia)

<400>  159

Tyr Tyr Asn Trp Pro Phe 
1               5       


<210>  160
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR1 (Contact)

<400>  160

Ser Asn Tyr Ala Val His 
1               5       


<210>  161
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR2 (Contact)

<400>  161

Trp Met Gly Arg Ile Ile Pro Ile Phe Gly Thr Thr Ser 
1               5                   10              


<210>  162
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR3 (Contact)

<400>  162

Ala Arg Gly Tyr Leu Gly Phe Ala Phe Asp 
1               5                   10  


<210>  163
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VL CDR1 (Contact)

<400>  163

Thr Thr Asn Leu Ala Trp Tyr 
1               5           


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VL CDR2 (Contact)

<400>  164

Leu Leu Ile Tyr Gly Ala Ser Thr Arg Val 
1               5                   10  


<210>  165
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VL CDR3 (Contact)

<400>  165

Gln Gln Tyr Tyr Asn Trp Pro Phe 
1               5               


<210>  166
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH CDR2 (AbM)

<400>  166

Arg Ile Ile Pro Ile Phe Gly Thr Thr Ser 
1               5                   10  


<210>  167
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VH Sequence

<400>  167

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Phe Gly Thr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Leu Gly Phe Ala Phe Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  168
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Clone F VL Sequence

<400>  168

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Gln Ser Val Thr Thr Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Val Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  169
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VH Sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is T or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is F or L

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Y, S or H

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is T, R or V

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is A, I, L or V

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is Q or R

<400>  169

Gly Gly Xaa Xaa Ser Ser Xaa Gly Ile Ser Gly Ile Ile Pro Ile Phe 
1               5                   10                  15      


Asp Xaa Xaa Asn Tyr Ala Gln Lys Phe Xaa Gly Tyr Tyr Val Gly Trp 
            20                  25                  30          


Gly Trp Phe Asp Val 
        35          


<210>  170
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus VL Sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is S, G or D

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is S, G or D

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is S or T

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X is A or S

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  X is A or L

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is Y or F

<400>  170

Arg Ala Ser Gln Ser Val Arg Xaa Thr Tyr Leu Ala Xaa Ala Xaa Ser 
1               5                   10                  15      


Arg Ala Thr Gln Gln Tyr Xaa Ser Xaa Pro Xaa Thr 
            20                  25              


