                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Vedere Bio, Inc.
       Flannery, John G.
       Geller, Scott F.
       Guerin, Karen I.
 
<120>  ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSIDS AND METHODS 
       OF USE THEREOF

<130>  BERK-422WO

<150>  US 63/032,206
<151>  2020-05-29

<160>  124   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  1

Leu Ala His Gln Asp Thr Thr Lys Asn Ser 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2

Leu Ala Leu Gly Glu Thr Thr Arg Ala Ala 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Leu Ala His Gln Asp Thr Thr Arg Pro Ala 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Leu Ala Arg Gln Asp Thr Thr Lys Asn Ala 
1               5                   10  


<210>  5
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Leu Ala His Gln Asp Ser Thr Lys Asn Ala 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Leu Ala His Gln Asp Ala Thr Lys Asn Ala 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Leu Ala His Gln Asp Thr Thr Lys Pro Ala 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8

Ile Ala Leu Ser Glu Thr Thr Arg Pro Ala 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Leu Ala His Gln Asp Thr Thr Lys Lys Cys 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Leu Ala Leu Gly Glu Ala Thr Arg Pro Ala 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Leu Ala Leu Gly Glu Thr Thr Arg Thr Ala 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Leu Ala Leu Ser Glu Ala Thr Arg Pro Ala 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Leu Ala Lys Asp Glu Thr Lys Asn Ser Ala 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14

Leu Ala Leu Gly Glu Thr Thr Lys Pro Ala 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15

Leu Ala His Gln Ala Thr Thr Lys Asn Ala 
1               5                   10  


<210>  16
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16

Leu Gln Arg Gly Asn Arg Gln Thr Thr Thr Ala Asp Val Asn Thr Gln 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17

Leu Gln Arg Gly Asn Arg Gln Ala Thr Thr Ala Asp Val Asn Thr Leu 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18

Leu Gln Arg Gly Asn Arg Gln Ala Thr Thr Glu Asp Val Asn Thr Gln 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  19

Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr Glu Asp Val Asn Thr Gln 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  20

Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Ser Leu 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  21

Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Lys Leu 
1               5                   10                  15      


<210>  22
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  22

Leu Gln Arg Gly Val Arg Val Pro Ser Val Leu Glu Val Asn Gly Gln 
1               5                   10                  15      


<210>  23
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  23

Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Ile Leu 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  24

Leu Gln Arg Gly Lys Arg Gln Ala Thr Thr Ala Asp Val Asn Thr Gln 
1               5                   10                  15      


<210>  25
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  25

Leu His Arg Gly Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Leu 
1               5                   10                  15      


<210>  26
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  26

Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Pro Thr Leu Gln 
1               5                   10                  15      


Phe Ser Gln 
            


<210>  27
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  27

Ser Lys Thr Asp Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln 
1               5                   10                  15      


Phe Ser Gln 
            


<210>  28
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  28

Ser Arg Thr Asp Thr Pro Ser Glu Thr Thr Thr Gln Ser Arg Leu Gln 
1               5                   10                  15      


Phe Ser Gln 
            


<210>  29
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  29

Ser Arg Thr Asn Ser Pro Ser Gly Thr Thr Thr Gln Ser Ser Leu Gln 
1               5                   10                  15      


Phe Ser Gln 
            


<210>  30
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  30

Ser Arg Thr Asp Ile Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln 
1               5                   10                  15      


Phe Ser Gln 
            


<210>  31
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  31

His Gln Asp Thr Thr Lys Asn 
1               5           


<210>  32
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  32

Leu Gly Glu Thr Thr Arg Ala 
1               5           


<210>  33
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  33

His Gln Asp Thr Thr Arg Pro 
1               5           


<210>  34
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  34

Arg Gln Asp Thr Thr Lys Asn 
1               5           


<210>  35
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  35

His Gln Asp Ser Thr Lys Asn 
1               5           


<210>  36
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  36

His Gln Asp Ala Thr Lys Asn 
1               5           


<210>  37
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  37

His Gln Asp Thr Thr Lys Pro 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  38

Leu Ser Glu Thr Thr Arg Pro 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  39

His Gln Asp Thr Thr Lys Lys 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  40

Leu Gly Glu Ala Thr Arg Pro 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  41

Leu Gly Glu Thr Thr Arg Thr 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  42

Leu Ser Glu Ala Thr Arg Pro 
1               5           


<210>  43
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  43

Lys Asp Glu Thr Lys Asn Ser 
1               5           


<210>  44
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  44

Leu Gly Glu Thr Thr Lys Pro 
1               5           


<210>  45
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  45

His Gln Ala Thr Thr Lys Asn 
1               5           


<210>  46
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (1)..(1)
<223>  The amino acid at position 1 is Leu or Ile

<220>
<221>  SITE
<222>  (3)..(3)
<223>  The amino acid at position 3 is His, Leu, Arg or Lys

<220>
<221>  SITE
<222>  (4)..(4)
<223>  The amino acid at position 4 is Gln, Gly, Ser or Asp

<220>
<221>  SITE
<222>  (5)..(5)
<223>  The amino acid at position 5 is Asp, Glu or Ala

<220>
<221>  SITE
<222>  (6)..(6)
<223>  The amino acid at position 6 is Thr or Ala

<220>
<221>  SITE
<222>  (8)..(8)
<223>  The amino acid at position 8 is Lys, Asn or Arg

<220>
<221>  SITE
<222>  (9)..(9)
<223>  The amino acid at position 9 is Asn, Pro, Ser, Lys, Thr or Ala

<220>
<221>  SITE
<222>  (10)..(10)
<223>  The amino acid at position 10 is Ser, Ala or Cys

<400>  46

Xaa Ala Xaa Xaa Xaa Xaa Thr Xaa Xaa Xaa 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (1)..(1)
<223>  The amino acid at position 1 is Leu or Ile

<220>
<221>  SITE
<222>  (3)..(3)
<223>  The amino acid at position 3 is His, Leu or Arg

<220>
<221>  SITE
<222>  (4)..(4)
<223>  The amino acid at position 4 is Gln, Gly or Ser

<220>
<221>  SITE
<222>  (5)..(5)
<223>  The amino acid at position 5 is Asp, Glu or Ala

<220>
<221>  SITE
<222>  (8)..(8)
<223>  The amino acid at position 8 is Lys or Arg

<220>
<221>  SITE
<222>  (9)..(9)
<223>  The amino acid at position 9 is Asn, Ala, Pro, Lys or Thr

<220>
<221>  SITE
<222>  (10)..(10)
<223>  The amino acid at position 10 is Ser, Ala or Cys

<400>  47

Xaa Ala Xaa Xaa Xaa Thr Thr Xaa Xaa Xaa 
1               5                   10  


<210>  48
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (5)..(5)
<223>  The amino acid at position 5 is Asp or Ala

<220>
<221>  SITE
<222>  (6)..(6)
<223>  The amino acid at position 6 is Thr, Ser or Ala

<220>
<221>  SITE
<222>  (8)..(8)
<223>  The amino acid at position 8 is Lys or Arg

<220>
<221>  SITE
<222>  (9)..(9)
<223>  The amino acid at position 9 is Asn, Pro or Lys

<220>
<221>  SITE
<222>  (10)..(10)
<223>  The amino acid at position 10 is Ser, Ala or Cys

<400>  48

Leu Ala His Gln Xaa Xaa Thr Xaa Xaa Xaa 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (4)..(4)
<223>  The amino acid at position 4 is Gly or Ser

<220>
<221>  SITE
<222>  (6)..(6)
<223>  The amino acid at position 6 is Thr or Ala

<220>
<221>  SITE
<222>  (8)..(8)
<223>  The amino acid at position 8 is Arg or Lys

<220>
<221>  SITE
<222>  (9)..(9)
<223>  The amino acid at position 9 is Ala, Pro or Thr

<400>  49

Leu Ala Leu Xaa Glu Xaa Thr Xaa Xaa Ala 
1               5                   10  


<210>  50
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (2)..(2)
<223>  The amino acid at position 2 is Gln or His

<220>
<221>  SITE
<222>  (5)..(5)
<223>  The amino acid at position 5 is Asn, Val or Lys

<220>
<221>  SITE
<222>  (8)..(8)
<223>  The amino acid at position 8 is Gln or Val

<220>
<221>  SITE
<222>  (9)..(9)
<223>  The amino acid at position 9 is Thr, Ala or Pro

<220>
<221>  SITE
<222>  (10)..(10)
<223>  The amino acid at position 10 is Thr, Ala or Ser

<220>
<221>  SITE
<222>  (11)..(11)
<223>  The amino acid at position 11 is Thr or Val

<220>
<221>  SITE
<222>  (12)..(12)
<223>  The amino acid at position 12 is Ala, Glu or Lys

<220>
<221>  SITE
<222>  (13)..(13)
<223>  The amino acid at position 13 is Asp or Glu

<220>
<221>  SITE
<222>  (16)..(16)
<223>  The amino acid at position 16 is Thr, Ser, Lys, Gly or Ile

<220>
<221>  SITE
<222>  (17)..(17)
<223>  The amino acid at position 17 is Gln or Leu

<400>  50

Leu Xaa Arg Gly Xaa Arg Gln Xaa Xaa Xaa Xaa Xaa Xaa Val Asn Xaa 
1               5                   10                  15      


Xaa 
    


<210>  51
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (2)..(2)
<223>  The amino acid at position 2 is Gln or His

<220>
<221>  SITE
<222>  (8)..(8)
<223>  The amino acid at position 8 is Ala or Thr

<220>
<221>  SITE
<222>  (9)..(9)
<223>  The amino acid at position 9 is Ala or Thr

<220>
<221>  SITE
<222>  (11)..(11)
<223>  The amino acid at position 11 is Ala or Glu

<220>
<221>  SITE
<222>  (15)..(15)
<223>  The amino acid at position 15 is Thr, Ser, Lys or Ile

<220>
<221>  SITE
<222>  (16)..(16)
<223>  The amino acid at position 16 is Gln or Leu

<400>  51

Leu Xaa Arg Gly Asn Arg Gln Xaa Xaa Thr Xaa Asp Val Asn Xaa Xaa 
1               5                   10                  15      


<210>  52
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (2)..(2)
<223>  The amino acid at position 2 is Arg or Lys

<220>
<221>  SITE
<222>  (4)..(4)
<223>  The amino acid at position 4 is Asn or Asp

<220>
<221>  SITE
<222>  (5)..(5)
<223>  The amino acid at position 5 is Thr, Ser or Ile

<220>
<221>  SITE
<222>  (8)..(8)
<223>  The amino acid at position 8 is Gly or Glu

<220>
<221>  SITE
<222>  (13)..(13)
<223>  The amino acid at position 13 is Ser or Pro

<220>
<221>  SITE
<222>  (14)..(14)
<223>  The amino acid at position 14 is Thr, Arg or Ser

<400>  52

Ser Xaa Thr Xaa Xaa Pro Ser Xaa Thr Thr Thr Gln Xaa Xaa Leu Gln 
1               5                   10                  15      


Phe Ser Gln 
            


<210>  53
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  SITE
<222>  (1)..(1)
<223>  The amino acid at position 1 is His, Leu, Arg or Lys

<220>
<221>  SITE
<222>  (2)..(2)
<223>  The amino acid at position 2 is Gln, Gly, Ser or Asp

<220>
<221>  SITE
<222>  (3)..(3)
<223>  The amino acid at position 3 is Asp, Glu or Ala

<220>
<221>  SITE
<222>  (4)..(4)
<223>  The amino acid at position 4 is Thr or Ala

<220>
<221>  SITE
<222>  (6)..(6)
<223>  The amino acid at position 6 is Lys, Asn or Arg

<220>
<221>  SITE
<222>  (7)..(7)
<223>  The amino acid at position 7 is Asn, Pro, Ser, Lys, Thr or Ala

<400>  53

Xaa Xaa Xaa Xaa Thr Xaa Xaa 
1               5           


<210>  54
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
1               5                   10                  15      


Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
            20                  25                  30          


Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
        35                  40                  45              


Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
    50                  55                  60                  


Ile Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
65                  70                  75                  80  


Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                85                  90                  95      


Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Val Val 
            100                 105                 110         


Asn Gln Val Tyr Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
        115                 120                 125             


Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
    130                 135                 140                 


Ala Ile Ile Ser Trp Glu Arg Trp Met Val Val Cys Lys Pro Phe Gly 
145                 150                 155                 160 


Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                165                 170                 175     


Trp Ile Trp Ala Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
            180                 185                 190         


Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
        195                 200                 205             


Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
    210                 215                 220                 


Val Thr Cys Cys Ile Thr Pro Leu Ser Ile Ile Val Leu Cys Tyr Leu 
225                 230                 235                 240 


Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                245                 250                 255     


Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
            260                 265                 270         


Met Val Leu Ala Phe Cys Phe Cys Trp Gly Pro Tyr Ala Phe Phe Ala 
        275                 280                 285             


Cys Phe Ala Ala Ala Asn Pro Gly Tyr Pro Phe His Pro Leu Met Ala 
    290                 295                 300                 


Ala Leu Pro Ala Phe Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
305                 310                 315                 320 


Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                325                 330                 335     


Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
            340                 345                 350         


Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
        355                 360                 


<210>  55
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
1               5                   10                  15      


Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
            20                  25                  30          


Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
        35                  40                  45              


Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
    50                  55                  60                  


Thr Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
65                  70                  75                  80  


Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                85                  90                  95      


Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Ile Val 
            100                 105                 110         


Asn Gln Val Ser Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
        115                 120                 125             


Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
    130                 135                 140                 


Ala Ile Ile Ser Trp Glu Arg Trp Met Val Val Cys Lys Pro Phe Gly 
145                 150                 155                 160 


Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                165                 170                 175     


Trp Ile Trp Ala Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
            180                 185                 190         


Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
        195                 200                 205             


Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
    210                 215                 220                 


Val Thr Cys Cys Ile Ile Pro Leu Ala Ile Ile Met Leu Cys Tyr Leu 
225                 230                 235                 240 


Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                245                 250                 255     


Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
            260                 265                 270         


Met Ile Phe Ala Tyr Cys Val Cys Trp Gly Pro Tyr Thr Phe Phe Ala 
        275                 280                 285             


Cys Phe Ala Ala Ala Asn Pro Gly Tyr Ala Phe His Pro Leu Met Ala 
    290                 295                 300                 


Ala Leu Pro Ala Tyr Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
305                 310                 315                 320 


Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                325                 330                 335     


Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
            340                 345                 350         


Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
        355                 360                 


<210>  56
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Arg Lys Met Ser Glu Glu Glu Phe Tyr Leu Phe Lys Asn Ile Ser 
1               5                   10                  15      


Ser Val Gly Pro Trp Asp Gly Pro Gln Tyr His Ile Ala Pro Val Trp 
            20                  25                  30          


Ala Phe Tyr Leu Gln Ala Ala Phe Met Gly Thr Val Phe Leu Ile Gly 
        35                  40                  45              


Phe Pro Leu Asn Ala Met Val Leu Val Ala Thr Leu Arg Tyr Lys Lys 
    50                  55                  60                  


Leu Arg Gln Pro Leu Asn Tyr Ile Leu Val Asn Val Ser Phe Gly Gly 
65                  70                  75                  80  


Phe Leu Leu Cys Ile Phe Ser Val Phe Pro Val Phe Val Ala Ser Cys 
                85                  90                  95      


Asn Gly Tyr Phe Val Phe Gly Arg His Val Cys Ala Leu Glu Gly Phe 
            100                 105                 110         


Leu Gly Thr Val Ala Gly Leu Val Thr Gly Trp Ser Leu Ala Phe Leu 
        115                 120                 125             


Ala Phe Glu Arg Tyr Ile Val Ile Cys Lys Pro Phe Gly Asn Phe Arg 
    130                 135                 140                 


Phe Ser Ser Lys His Ala Leu Thr Val Val Leu Ala Thr Trp Thr Ile 
145                 150                 155                 160 


Gly Ile Gly Val Ser Ile Pro Pro Phe Phe Gly Trp Ser Arg Phe Ile 
                165                 170                 175     


Pro Glu Gly Leu Gln Cys Ser Cys Gly Pro Asp Trp Tyr Thr Val Gly 
            180                 185                 190         


Thr Lys Tyr Arg Ser Glu Ser Tyr Thr Trp Phe Leu Phe Ile Phe Cys 
        195                 200                 205             


Phe Ile Val Pro Leu Ser Leu Ile Cys Phe Ser Tyr Thr Gln Leu Leu 
    210                 215                 220                 


Arg Ala Leu Lys Ala Val Ala Ala Gln Gln Gln Glu Ser Ala Thr Thr 
225                 230                 235                 240 


Gln Lys Ala Glu Arg Glu Val Ser Arg Met Val Val Val Met Val Gly 
                245                 250                 255     


Ser Phe Cys Val Cys Tyr Val Pro Tyr Ala Ala Phe Ala Met Tyr Met 
            260                 265                 270         


Val Asn Asn Arg Asn His Gly Leu Asp Leu Arg Leu Val Thr Ile Pro 
        275                 280                 285             


Ser Phe Phe Ser Lys Ser Ala Cys Ile Tyr Asn Pro Ile Ile Tyr Cys 
    290                 295                 300                 


Phe Met Asn Lys Gln Phe Gln Ala Cys Ile Met Lys Met Val Cys Gly 
305                 310                 315                 320 


Lys Ala Met Thr Asp Glu Ser Asp Thr Cys Ser Ser Gln Lys Thr Glu 
                325                 330                 335     


Val Ser Thr Val Ser Ser Thr Gln Val Gly Pro Asn 
            340                 345             


<210>  57
<211>  27
<212>  RNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  57
cgcaaucagu gaaugcuuau acauccg                                           27


<210>  58
<211>  497
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  58

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Asp 
1               5                   10                  15      


Lys Gly Ala Lys Lys Ala Asn Lys Asp Asp Gly Arg Gly Val Gly Tyr 
            20                  25                  30          


Lys Tyr Gly Asn Gly Asp Lys Gly Val Asn Ala Ala Asp Ala Ala Ala 
        35                  40                  45              


His Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Arg Tyr Asn His 
    50                  55                  60                  


Ala Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys 
65                  70                  75                  80  


Lys Arg Val Gly Val Gly Ala Lys Thr Ala Gly Lys Lys Arg Val Ser 
                85                  90                  95      


Asp Ser Ser Ser Gly Gly Lys Thr Gly Ala Lys Lys Arg Asn Gly Thr 
            100                 105                 110         


Gly Asp Ser Ser Val Asp Gly Ala Thr Ala Ala Val Gly Thr Thr Met 
        115                 120                 125             


Ala Ser Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala Asp Gly Val 
    130                 135                 140                 


Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Gly Asp Arg 
145                 150                 155                 160 


Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn His Tyr Lys 
                165                 170                 175     


Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His Tyr Gly Tyr Ser 
            180                 185                 190         


Thr Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp Arg Asn 
        195                 200                 205             


Asn Asn Trp Gly Arg Lys Arg Asn Lys Asn Val Lys Val Thr Thr Asn 
    210                 215                 220                 


Asp Gly Val Thr Thr Ala Asn Asn Thr Ser Thr Val Val Ser Asp Ser 
225                 230                 235                 240 


Tyr Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Tyr Gly Tyr 
                245                 250                 255     


Thr Asn Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr Ser Met 
            260                 265                 270         


Arg Thr Gly Asn Asn Thr Ser Tyr Thr Val His Ser Ser Tyr Ala His 
        275                 280                 285             


Ser Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Asn Arg Thr Asn Ser Gly 
    290                 295                 300                 


Ser Ala Asn Lys Asp Ser Arg Gly Ser Ala Gly Met Ser Val Lys Asn 
305                 310                 315                 320 


Trp Gly Cys Tyr Arg Arg Val Ser Lys Thr Lys Thr Asp Asn Asn Asn 
                325                 330                 335     


Ser Asn Thr Trp Thr Gly Ala Ser Lys Tyr Asn Asn Gly Arg Ser Asn 
            340                 345                 350         


Gly Thr Ala Met Ala Ser His Lys Asp Asp Asp Lys Met Ser Gly Val 
        355                 360                 365             


Met Gly Lys Ser Ala Gly Ala Ser Asn Thr Ala Asp Asn Val Met Thr 
    370                 375                 380                 


Asp Lys Ala Thr Asn Val Ala Thr Arg Gly Thr Val Ala Val Asn Ser 
385                 390                 395                 400 


Ser Ser Thr Asp Ala Thr Gly Asp Val His Ala Met Gly Ala Gly Met 
                405                 410                 415     


Val Trp Asp Arg Asp Val Tyr Gly Trp Ala Lys His Thr Asp Gly His 
            420                 425                 430         


His Ser Met Gly Gly Gly Lys Asn Lys Asn Thr Val Ala Asn Ala Ser 
        435                 440                 445             


Ala Thr Lys Ala Ser Thr Tyr Ser Thr Gly Val Ser Val Trp Lys Asn 
    450                 455                 460                 


Ser Lys Arg Trp Asn Val Tyr Thr Ser Asn Tyr Ala Lys Ser Ala Asn 
465                 470                 475                 480 


Val Asp Thr Val Asp Asn Asn Gly Tyr Thr Arg Gly Thr Arg Tyr Thr 
                485                 490                 495     


Arg 
    


<210>  59
<211>  499
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  59

Met Ala Ala Asp Gly Tyr Asp Trp Asp Thr Ser Gly Arg Trp Trp Lys 
1               5                   10                  15      


Lys Gly Lys Ala Arg His Lys Asp Asp Ser Arg Gly Val Gly Tyr Lys 
            20                  25                  30          


Tyr Gly Asn Gly Asp Lys Gly Val Asn Ala Asp Ala Ala Ala His Asp 
        35                  40                  45              


Lys Ala Tyr Asp Arg Asp Ser Gly Asp Asn Tyr Lys Tyr Asn His Ala 
    50                  55                  60                  


Asp Ala Arg Lys Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys 
65                  70                  75                  80  


Lys Arg Val Gly Val Val Lys Thr Ala Gly Lys Lys Arg Val His Ser 
                85                  90                  95      


Val Asp Ser Ser Ser Gly Thr Gly Lys Ala Gly Ala Arg Lys Arg Asn 
            100                 105                 110         


Gly Thr Gly Asp Ala Asp Ser Val Asp Gly Ala Ala Ser Gly Gly Thr 
        115                 120                 125             


Asn Thr Met Ala Thr Gly Ser Gly Ala Met Ala Asp Asn Asn Gly Ala 
    130                 135                 140                 


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
145                 150                 155                 160 


Met Gly Asp Arg Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn 
                165                 170                 175     


Asn His Tyr Lys Ser Ser Ser Gly Ala Ser Asn Asp Asn His Tyr Gly 
            180                 185                 190         


Tyr Ser Thr Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp 
        195                 200                 205             


Arg Asn Asn Asn Trp Gly Arg Lys Arg Asn Lys Asn Val Lys Val Thr 
    210                 215                 220                 


Asn Asp Gly Thr Thr Thr Ala Asn Asn Thr Ser Thr Val Val Thr Asp 
225                 230                 235                 240 


Ser Tyr Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Val Tyr 
                245                 250                 255     


Gly Tyr Thr Asn Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr 
            260                 265                 270         


Ser Met Arg Thr Gly Asn Asn Thr Ser Tyr Thr Asp Val His Ser Ser 
        275                 280                 285             


Tyr Ala His Ser Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Ser Arg Thr 
    290                 295                 300                 


Asn Thr Ser Gly Thr Thr Thr Ser Arg Ser Ala Gly Ala Ser Asp Arg 
305                 310                 315                 320 


Asp Ser Arg Asn Trp Gly Cys Tyr Arg Arg Val Ser Lys Thr Ser Ala 
                325                 330                 335     


Asp Asn Asn Asn Ser Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Asn 
            340                 345                 350         


Gly Arg Asp Ser Val Asn Gly Ala Met Ala Ser His Lys Asp Asp Lys 
        355                 360                 365             


Ser Gly Val Gly Lys Gly Ser Lys Thr Asn Val Asp Lys Val Met Thr 
    370                 375                 380                 


Asp Arg Thr Thr Asn Val Ala Thr Tyr Gly Ser Val Ser Thr Asn Arg 
385                 390                 395                 400 


Gly Asn Arg Ala Ala Thr Ala Asp Val Asn Thr Gly Val Gly Met Val 
                405                 410                 415     


Trp Asp Arg Asp Val Tyr Gly Trp Ala Lys His Thr Asp Gly His His 
            420                 425                 430         


Ser Met Gly Gly Gly Lys His Lys Asn Thr Val Ala Asn Ser Thr Thr 
        435                 440                 445             


Ser Ala Ala Lys Ala Ser Thr Tyr Ser Thr Gly Val Ser Val Trp Lys 
    450                 455                 460                 


Asn Ser Lys Arg Trp Asn Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn 
465                 470                 475                 480 


Val Asp Thr Val Asp Thr Asn Gly Val Tyr Ser Arg Gly Thr Arg Tyr 
                485                 490                 495     


Thr Arg Asn 
            


<210>  60
<211>  494
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  60

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Ala 
1               5                   10                  15      


Lys Gly Val Lys Ala Asn His Asp Asn Arg Arg Gly Val Gly Tyr Lys 
            20                  25                  30          


Tyr Gly Gly Asn Gly Asp Lys Gly Val Asn Ala Asp Ala Ala Ala His 
        35                  40                  45              


Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Lys Tyr Asn His Ala 
    50                  55                  60                  


Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys Lys 
65                  70                  75                  80  


Arg Gly Val Ala Ala Lys Thr Ala Gly Lys Lys Gly Ala Val Asp Ser 
                85                  90                  95      


Asp Ser Ser Ser Gly Val Gly Lys Ser Gly Lys Ala Arg Lys Arg Asn 
            100                 105                 110         


Gly Thr Gly Asp Ser Ser Val Asp Gly Ala Ala Thr Ser Gly Ser Asn 
        115                 120                 125             


Thr Met Ala Ser Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala Asp 
    130                 135                 140                 


Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Trp Gly Asp 
145                 150                 155                 160 


Arg Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn His Tyr 
                165                 170                 175     


Lys Ser Ser Ser Gly Ala Ser Asn Asp Asn His Tyr Gly Tyr Ser Thr 
            180                 185                 190         


Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp Arg Asn Asn 
        195                 200                 205             


Asn Trp Gly Arg Lys Lys Ser Lys Asn Val Arg Gly Val Thr Asn Asp 
    210                 215                 220                 


Gly Thr Thr Thr Ala Asn Asn Thr Ser Thr Val Val Thr Asp Ser Tyr 
225                 230                 235                 240 


Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Val Tyr Gly Tyr 
                245                 250                 255     


Thr Asn Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr Ser Met 
            260                 265                 270         


Arg Thr Gly Asn Asn Ser Tyr Thr Asp Val His Ser Ser Tyr Ala His 
        275                 280                 285             


Ser Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Asn Arg Thr Gly Thr Thr 
    290                 295                 300                 


Ser Gly Thr Thr Asn Ser Arg Ser Ala Gly Ser Met Ser Ala Arg Asn 
305                 310                 315                 320 


Trp Gly Cys Tyr Arg Arg Ser Lys Thr Ala Asn Asp Asn Asn Asn Ser 
                325                 330                 335     


Asn Trp Thr Ala Ala Ser Lys Tyr His Asn Gly Arg Asp Ser Val Asn 
            340                 345                 350         


Gly Ala Met Ala Ser His Lys Asp Asp Lys Met His Gly Asn Gly Lys 
        355                 360                 365             


Gly Thr Thr Ala Ser Asn Ala Asp Asn Val Met Thr Asp Arg Thr Thr 
    370                 375                 380                 


Asn Val Ala Thr Tyr Gly Thr Val Ala Asn Asn Ser Ser Asn Thr Ala 
385                 390                 395                 400 


Thr Thr Gly Thr Val Asn His Gly Ala Gly Met Val Trp Asp Arg Asp 
                405                 410                 415     


Val Tyr Gly Trp Ala Lys His Thr Asp Gly His His Ser Met Gly Gly 
            420                 425                 430         


Gly Lys His Met Lys Asn Thr Val Ala Asn Thr Thr Ser Ala Lys Ala 
        435                 440                 445             


Ser Thr Tyr Ser Thr Gly Val Ser Val Trp Lys Asn Ser Lys Arg Trp 
    450                 455                 460                 


Asn Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Thr Val Asp 
465                 470                 475                 480 


Thr Asn Gly Val Tyr Ser Arg Gly Thr Arg Tyr Thr Arg Asn 
                485                 490                 


<210>  61
<211>  492
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  61

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Ala 
1               5                   10                  15      


Lys Gly Val Lys Ala Asn His Asp Asn Arg Arg Gly Val Gly Tyr Lys 
            20                  25                  30          


Tyr Gly Gly Asn Gly Asp Lys Gly Val Asn Ala Asp Ala Ala Ala His 
        35                  40                  45              


Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Lys Tyr Asn His Ala 
    50                  55                  60                  


Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys Lys 
65                  70                  75                  80  


Arg Gly Val Ala Ala Lys Thr Ala Gly Lys Lys Arg Val Asp Ser Asp 
                85                  90                  95      


Ser Ser Ser Gly Val Gly Lys Ser Gly Lys Ala Arg Lys Arg Asn Gly 
            100                 105                 110         


Thr Gly Asp Ser Ser Val Asp Gly Ala Ala Thr Ser Gly Ser Asn Thr 
        115                 120                 125             


Met Ala Ser Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala Asp Gly 
    130                 135                 140                 


Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Trp Gly Asp Arg 
145                 150                 155                 160 


Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn His Tyr Lys 
                165                 170                 175     


Ser Ser Ser Gly Ala Ser Asn Asp Asn His Tyr Gly Tyr Ser Thr Trp 
            180                 185                 190         


Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp Arg Asn Asn Asn 
        195                 200                 205             


Trp Gly Arg Lys Lys Ser Lys Asn Val Lys Val Thr Asn Asp Gly Thr 
    210                 215                 220                 


Thr Thr Ala Asn Asn Thr Ser Thr Val Val Thr Asp Ser Tyr Tyr Val 
225                 230                 235                 240 


Gly Ser Ala His Gly Cys Ala Asp Val Met Val Tyr Gly Tyr Thr Asn 
                245                 250                 255     


Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr Ser Met Arg Thr 
            260                 265                 270         


Gly Asn Asn Ser Tyr Thr Asp Val His Ser Ser Tyr Ala His Ser Ser 
        275                 280                 285             


Asp Arg Met Asn Asp Tyr Tyr Tyr Asn Arg Thr Gly Thr Thr Ser Gly 
    290                 295                 300                 


Thr Thr Asn Ser Arg Ser Ala Gly Ser Met Ser Ala Arg Asn Trp Gly 
305                 310                 315                 320 


Cys Tyr Arg Arg Ser Lys Thr Ala Asn Asp Asn Asn Asn Ser Asn Trp 
                325                 330                 335     


Thr Ala Ala Ser Lys Tyr His Asn Gly Arg Asp Ser Val Asn Gly Ala 
            340                 345                 350         


Met Ala Ser His Lys Asp Asp Lys Met His Gly Asn Gly Lys Gly Thr 
        355                 360                 365             


Thr Ala Ser Asn Ala Asp Asn Val Met Thr Asp Arg Thr Thr Asn Val 
    370                 375                 380                 


Ala Thr Tyr Gly Thr Val Ala Asn Asn Ser Ser Asn Thr Ala Thr Thr 
385                 390                 395                 400 


Arg Thr Val Asn Asp Gly Ala Gly Met Val Trp Asp Arg Asp Val Tyr 
                405                 410                 415     


Gly Trp Ala Lys His Thr Asp Gly His His Ser Met Gly Gly Gly Lys 
            420                 425                 430         


His Met Lys Asn Thr Val Ala Asn Thr Thr Ser Ala Lys Ala Ser Thr 
        435                 440                 445             


Tyr Ser Thr Gly Val Ser Val Trp Lys Asn Ser Lys Arg Trp Asn Tyr 
    450                 455                 460                 


Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Thr Val Asp Thr Asn 
465                 470                 475                 480 


Gly Val Tyr Ser Arg Gly Thr Arg Tyr Thr Arg Asn 
                485                 490         


<210>  62
<211>  496
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  62

Met Thr Asp Gly Tyr Asp Trp Asp Asn Ser Gly Val Arg Trp Trp Ala 
1               5                   10                  15      


Gly Ala Lys Lys Ala Asn His Asp Asn Ala Arg Gly Val Gly Tyr Lys 
            20                  25                  30          


Tyr Gly Gly Asn Gly Asp Lys Gly Val Asn Ala Ala Asp Ala Ala Ala 
        35                  40                  45              


His Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Lys Tyr Asn His 
    50                  55                  60                  


Ala Asp Ala Arg Gly Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala 
65                  70                  75                  80  


Lys Lys Arg Val Gly Val Ala Gly Thr Ala Gly Lys Lys Arg Ser Asp 
                85                  90                  95      


Ser Ser Thr Gly Gly Lys Lys Gly Lys Ala Lys Lys Lys Val Asp Thr 
            100                 105                 110         


Gly Ala Gly Asp Gly Gly Ser Thr Ser Gly Ala Met Ser Asp Asp Ser 
        115                 120                 125             


Met Arg Ala Ala Ala Gly Gly Ala Ala Val Gly Gly Gly Ala Asp Gly 
    130                 135                 140                 


Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp Ser Gly 
145                 150                 155                 160 


His Val Thr Thr Thr Ser Thr Arg Thr Trp Val Thr Tyr Asn Asn His 
                165                 170                 175     


Tyr Lys Arg Gly Ser Ser Asn Thr Tyr Asn Gly Ser Thr Trp Gly Tyr 
            180                 185                 190         


Asp Asn Arg His Cys His Ser Arg Asp Trp Arg Asn Asn Asn Trp Gly 
        195                 200                 205             


Met Arg Lys Ala Met Arg Val Lys Asn Val Lys Val Thr Thr Ser Asn 
    210                 215                 220                 


Gly Thr Thr Val Ala Asn Asn Thr Ser Thr Val Ala Asp Ser Ser Tyr 
225                 230                 235                 240 


Tyr Val Met Asp Ala Gly Gly Ser Asn Asp Val Met Val Tyr Gly Tyr 
                245                 250                 255     


Cys Gly Val Thr Gly Asn Thr Ser Thr Asp Arg Asn Ala Tyr Cys Tyr 
            260                 265                 270         


Ser Met Arg Thr Gly Asn Asn Thr Tyr Ser Lys Val His Ser Met Tyr 
        275                 280                 285             


Ala His Ser Ser Asp Arg Met Asn Asp Tyr Trp Gly Ser Thr Thr Thr 
    290                 295                 300                 


Gly Thr Thr Asn Ala Gly Thr Ala Thr Thr Asn Thr Lys Arg Thr Asn 
305                 310                 315                 320 


Ser Asn Lys Lys Asn Trp Gly Ser Lys Gly Ser Lys Thr Ala Asn Asn 
                325                 330                 335     


Tyr Lys Ala Thr Gly Ser Asp Ser Lys Tyr Thr His Ser Thr Asp Gly 
            340                 345                 350         


Arg Trp Ser Ala Thr Gly Met Ala Thr Ala Gly Ala Asp Ser Lys Ser 
        355                 360                 365             


Asn Ser Ala Gly Lys Asn Gly Asn Thr Ala Thr Val Gly Thr Thr Ser 
    370                 375                 380                 


Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly Asn Gly Gly Asp 
385                 390                 395                 400 


Ser Asn Ser Asn Thr Val Asp Arg Thr Ala Gly Ala Val Gly Met Val 
                405                 410                 415     


Trp Asn Arg Asp Tyr Tyr Gly Trp Ala Lys His Thr Asp Gly His His 
            420                 425                 430         


Ser Gly Gly Gly Lys His Lys Asn Thr Val Ala Asn Ala Thr Thr Ser 
        435                 440                 445             


Ser Thr Val Asn Ser Thr Tyr Ser Thr Gly Val Ser Val Asp Trp Lys 
    450                 455                 460                 


Arg Ser Lys Arg Trp Asn Val Thr Ser Asn Tyr Gly Asn Ser Trp Ala 
465                 470                 475                 480 


Asp Ala Ala Gly Lys Tyr Thr Arg Ala Gly Thr Arg Tyr Thr His His 
                485                 490                 495     


<210>  63
<211>  724
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  63

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  64
<211>  499
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  64

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Asp 
1               5                   10                  15      


Lys Gly Ala Lys Lys Ala Asn Lys Asp Asp Gly Arg Gly Val Gly Tyr 
            20                  25                  30          


Lys Tyr Gly Asn Gly Asp Lys Gly Val Asn Ala Ala Asp Ala Ala Ala 
        35                  40                  45              


His Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Arg Tyr Asn His 
    50                  55                  60                  


Ala Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys 
65                  70                  75                  80  


Lys Arg Val Gly Val Gly Ala Lys Thr Ala Gly Lys Lys Arg Val Ser 
                85                  90                  95      


Asp Ser Ser Ser Gly Gly Lys Thr Gly Ala Lys Lys Arg Asn Gly Thr 
            100                 105                 110         


Gly Asp Ser Ser Val Asp Gly Ala Thr Ala Ala Val Gly Thr Thr Met 
        115                 120                 125             


Ala Ser Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala Asp Gly Val 
    130                 135                 140                 


Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Gly Asp Arg 
145                 150                 155                 160 


Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn His Tyr Lys 
                165                 170                 175     


Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His Tyr Gly Tyr Ser 
            180                 185                 190         


Thr Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp Arg Asn 
        195                 200                 205             


Asn Asn Trp Gly Arg Lys Arg Asn Lys Asn Val Lys Val Thr Thr Asn 
    210                 215                 220                 


Asp Gly Val Thr Thr Ala Asn Asn Thr Ser Thr Val Val Ser Asp Ser 
225                 230                 235                 240 


Tyr Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Tyr Gly Tyr 
                245                 250                 255     


Thr Asn Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr Ser Met 
            260                 265                 270         


Arg Thr Gly Asn Asn Thr Ser Tyr Thr Asp Val His Ser Ser Tyr Ala 
        275                 280                 285             


His Ser Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Asn Arg Thr Asn Ser 
    290                 295                 300                 


Gly Ser Ala Asn Lys Asp Ser Arg Gly Ser Ala Gly Met Ser Val Lys 
305                 310                 315                 320 


Asn Trp Gly Cys Tyr Arg Arg Val Ser Lys Thr Lys Thr Asp Asn Asn 
                325                 330                 335     


Asn Ser Asn Thr Trp Thr Gly Ala Ser Lys Tyr Asn Asn Gly Arg Ser 
            340                 345                 350         


Asn Gly Thr Ala Met Ala Ser His Lys Asp Asp Lys Asp Lys Met Ser 
        355                 360                 365             


Gly Val Met Gly Lys Ser Ala Gly Ala Ser Asn Thr Ala Asp Asn Val 
    370                 375                 380                 


Met Thr Asp Lys Ala Thr Asn Val Ala Thr Arg Gly Thr Val Ala Val 
385                 390                 395                 400 


Asn Ser Ser Ser Thr Asp Ala Thr Gly Asp Val His Val Met Gly Ala 
                405                 410                 415     


Gly Met Val Trp Asp Arg Asp Val Tyr Gly Trp Ala Lys His Thr Asp 
            420                 425                 430         


Gly His His Ser Met Gly Gly Gly Lys His Lys Asn Thr Val Ala Asn 
        435                 440                 445             


Ala Ser Ala Thr Lys Ala Ser Thr Tyr Ser Thr Gly Val Ser Val Trp 
    450                 455                 460                 


Lys Asn Ser Lys Arg Trp Asn Val Tyr Thr Ser Asn Tyr Ala Lys Ser 
465                 470                 475                 480 


Ala Asn Val Asp Thr Val Asp Asn Asn Gly Tyr Thr Arg Gly Thr Arg 
                485                 490                 495     


Tyr Thr Arg 
            


<210>  65
<211>  487
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  65

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Asp 
1               5                   10                  15      


Lys Gly Ala Lys Lys Ala Asn Lys Asp Asn Gly Arg Gly Val Gly Tyr 
            20                  25                  30          


Lys Tyr Gly Asn Gly Asp Lys Gly Val Asn Ala Ala Asp Ala Ala Ala 
        35                  40                  45              


His Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Arg Tyr Asn His 
    50                  55                  60                  


Ala Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys 
65                  70                  75                  80  


Lys Arg Val Gly Val Gly Ala Lys Thr Ala Ala Lys Lys Arg Val Ser 
                85                  90                  95      


Arg Ser Asp Ser Ser Thr Gly Gly Lys Lys Gly Ala Arg Lys Arg Asn 
            100                 105                 110         


Gly Thr Gly Asp Ser Ser Val Asp Gly Ala Ala Ser Ser Val Gly Ser 
        115                 120                 125             


Gly Thr Val Ala Ala Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala 
    130                 135                 140                 


Asp Gly Val Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
145                 150                 155                 160 


Gly Asp Arg Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn 
                165                 170                 175     


His Tyr Lys Ser Ser Thr Ala Gly Ser Thr Asn Asp Asn Thr Tyr Gly 
            180                 185                 190         


Tyr Ser Thr Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp 
        195                 200                 205             


Arg Asn Asn Asn Trp Gly Arg Lys Lys Arg Lys Asn Val Lys Val Thr 
    210                 215                 220                 


Thr Asn Asp Gly Val Thr Thr Ala Asn Asn Thr Ser Thr Val Ser Asp 
225                 230                 235                 240 


Ser Tyr Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Tyr Gly 
                245                 250                 255     


Tyr Thr Asn Asn Gly Ser Ser Val Gly Arg Ser Ser Tyr Cys Tyr Ser 
            260                 265                 270         


Met Arg Thr Gly Asn Asn Ser Tyr Ser Asp Val His Ser Ser Tyr Ala 
        275                 280                 285             


His Ser Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Ala Arg Thr Ser Asn 
    290                 295                 300                 


Gly Gly Thr Ala Gly Asn Arg Tyr Gly Gly Ser Thr Met Ala Ala Lys 
305                 310                 315                 320 


Asn Trp Gly Cys Arg Arg Val Ser Lys Thr Asp Asn Asn Asn Ser Asn 
                325                 330                 335     


Ala Trp Thr Gly Ala Thr Lys Tyr His Asn Gly Arg Asn Ser Val Asn 
            340                 345                 350         


Gly Val Ala Met Ala Thr His Lys Asp Asp Asp Arg Ser Ser Gly Val 
        355                 360                 365             


Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Asn Val Met Thr Asn Arg 
    370                 375                 380                 


Thr Asn Val Ala Thr Tyr Gly Val Ser Ser Asn Ala Ala Asn Thr Ala 
385                 390                 395                 400 


Ala Thr Val Val Asn Asn Gly Ala Gly Met Val Trp Asn Arg Asp Val 
                405                 410                 415     


Tyr Gly Trp Ala Lys His Thr Asp Gly Asn His Ser Met Gly Gly Gly 
            420                 425                 430         


Lys His Lys Asn Thr Val Ala Asn Val Thr Ala Lys Ala Ser Thr Tyr 
        435                 440                 445             


Ser Thr Gly Val Ser Val Trp Lys Asn Ser Lys Arg Trp Asn Tyr Thr 
    450                 455                 460                 


Ser Asn Lys Thr Gly Val Asp Ala Val Asp Ser Gly Val Tyr Ser Arg 
465                 470                 475                 480 


Gly Thr Arg Tyr Thr Arg Asn 
                485         


<210>  66
<211>  490
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  66

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Ala 
1               5                   10                  15      


Lys Gly Ala Lys Lys Ala Asn Lys Asp Asp Gly Arg Gly Val Gly Tyr 
            20                  25                  30          


Lys Tyr Gly Asn Gly Asp Lys Gly Val Asn Ala Ala Asp Ala Ala Ala 
        35                  40                  45              


His Asp Lys Ala Tyr Asp Ala Gly Asp Asn Tyr Arg Tyr Asn His Ala 
    50                  55                  60                  


Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys Lys 
65                  70                  75                  80  


Arg Val Gly Val Gly Ala Lys Thr Ala Gly Lys Lys Arg Val Ser Arg 
                85                  90                  95      


Ser Asp Ser Ser Thr Gly Gly Lys Lys Gly Ala Arg Lys Arg Asn Gly 
            100                 105                 110         


Thr Gly Asp Ser Ser Val Asp Gly Ala Ala Ser Gly Val Gly Asn Thr 
        115                 120                 125             


Met Ala Ala Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala Asp Gly 
    130                 135                 140                 


Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Gly Asp 
145                 150                 155                 160 


Arg Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn His Tyr 
                165                 170                 175     


Lys Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn Thr Tyr Gly 
            180                 185                 190         


Tyr Ser Thr Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp 
        195                 200                 205             


Arg Asn Asn Asn Trp Gly Arg Lys Arg Ser Lys Asn Val Lys Val Thr 
    210                 215                 220                 


Asn Gly Thr Lys Thr Ala Asn Asn Thr Ser Thr Val Thr Asp Ser Tyr 
225                 230                 235                 240 


Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Tyr Gly Tyr Thr 
                245                 250                 255     


Asn Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr Ser Met Arg 
            260                 265                 270         


Thr Gly Asn Asn Thr Tyr Thr Asp Val His Ser Ser Tyr Ala His Ser 
        275                 280                 285             


Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Ser Arg Thr Thr Thr Gly Gly 
    290                 295                 300                 


Thr Ala Asn Thr Thr Gly Ser Gly Gly Asn Thr Met Ala Asn Ala Lys 
305                 310                 315                 320 


Asn Trp Gly Cys Tyr Arg Arg Val Ser Thr Thr Thr Gly Asn Asn Asn 
                325                 330                 335     


Ser Asn Ala Trp Thr Ala Gly Thr Lys Tyr His Asn Gly Arg Asn Ser 
            340                 345                 350         


Ala Asn Gly Ala Met Ala Thr His Lys Asp Asp Arg Ser Asn Gly Gly 
        355                 360                 365             


Lys Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Thr Ser 
    370                 375                 380                 


Lys Thr Thr Asn Val Ala Thr Tyr Gly Val Ala Asp Asn Asn Thr Ala 
385                 390                 395                 400 


Gly Thr Val Asn Ser Gly Ala Gly Met Val Trp Asn Arg Asp Val Tyr 
                405                 410                 415     


Gly Trp Ala Lys His Thr Asp Gly Asn His Ser Met Gly Gly Gly Lys 
            420                 425                 430         


His Lys Asn Thr Val Ala Asp Thr Thr Asn Ser Lys Asn Ser Thr Tyr 
        435                 440                 445             


Ser Thr Gly Val Ser Val Trp Lys Asn Ser Lys Arg Trp Asn Tyr Thr 
    450                 455                 460                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Ala Val Asn Thr Gly Val 
465                 470                 475                 480 


Tyr Ser Arg Gly Thr Arg Tyr Thr Arg Asn 
                485                 490 


<210>  67
<211>  737
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus


<220>
<221>  SITE
<222>  (264)..(264)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (266)..(266)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (268)..(268)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (448)..(448)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (459)..(460)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (467)..(467)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (470)..(471)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (474)..(474)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (495)..(495)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (516)..(516)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (533)..(533)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (547)..(547)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (551)..(551)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (555)..(555)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (557)..(557)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (561)..(561)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (563)..(563)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (577)..(577)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (583)..(583)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (593)..(593)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (596)..(596)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (661)..(662)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (664)..(665)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (710)..(710)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (717)..(719)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (723)..(723)
<223>  Xaa can be any naturally occurring amino acid

<400>  67

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Xaa Ser Xaa Gly Xaa Thr Asn Asp Asn 
            260                 265                 270         


His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Xaa 
        435                 440                 445             


Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Xaa Xaa Glu Leu Leu Phe 
    450                 455                 460                 


Ser Gln Xaa Gly Pro Xaa Xaa Met Ser Xaa Gln Ala Lys Asn Trp Leu 
465                 470                 475                 480 


Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Leu Xaa Gln 
                485                 490                 495     


Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His Leu 
            500                 505                 510         


Asn Gly Arg Xaa Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr His 
        515                 520                 525             


Lys Asp Asp Glu Xaa Arg Phe Phe Pro Ser Ser Gly Val Leu Ile Phe 
    530                 535                 540                 


Gly Lys Xaa Gly Ala Gly Xaa Asn Asn Thr Xaa Leu Xaa Asn Val Met 
545                 550                 555                 560 


Xaa Thr Xaa Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Xaa Tyr Gly Val Val Ala Xaa Asn Leu Gln Ser Ser Asn Thr Ala Pro 
            580                 585                 590         


Xaa Thr Gly Xaa Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Xaa Xaa Phe Xaa Xaa Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Tyr Ala Lys Ser Xaa Asn Val Asp Phe Ala Val Xaa Xaa Xaa Gly 
705                 710                 715                 720 


Val Tyr Xaa Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  68
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  68

Pro Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg 
1               5                   10                  15      


Gly Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu 
            20                  25                  30          


Pro Gly Met Val Trp Gln Asp Arg Asp Val 
        35                  40          


<210>  69
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  69

Pro Val Ala Thr Glu Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser 
1               5                   10                  15      


Ser Ser Thr Asp Pro Ala Thr Gly Asp Val His Ala Met Gly Ala Leu 
            20                  25                  30          


Pro Gly Met Val Trp Gln Asp Arg Asp Val 
        35                  40          


<210>  70
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  70

Arg Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser 
1               5                   10                  15      


Ser Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val 
            20                  25                  30          


Pro Gly Ser Val Trp Met Glu Arg Asp Val 
        35                  40          


<210>  71
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  71

Pro Val Ala Thr Glu Arg Phe Gly Thr Val Ala Val Asn Leu Gln Ser 
1               5                   10                  15      


Ser Ser Thr Asp Pro Ala Thr Gly Asp Val His Val Met Gly Ala Leu 
            20                  25                  30          


Pro Gly Met Val Trp Gln Asp Arg Asp Val 
        35                  40          


<210>  72
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  72

Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala 
1               5                   10                  15      


Ala Asn Thr Ala Ala Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu 
            20                  25                  30          


Pro Gly Met Val Trp Gln Asn Arg Asp Val 
        35                  40          


<210>  73
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  73

Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln 
1               5                   10                  15      


Gln Asn Thr Ala Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu 
            20                  25                  30          


Pro Gly Met Val Trp Gln Asn Arg Asp Val 
        35                  40          


<210>  74
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  74

Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            20                  25                  30          


Pro Gly Met Val Trp Gln Asp Arg Asp Val 
        35                  40          


<210>  75
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  75

Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln 
1               5                   10                  15      


Ala Asn Thr Gly Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu 
            20                  25                  30          


Pro Gly Met Val Trp Gln Asn Arg Asp Val 
        35                  40          


<210>  76
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  76

Ala Thr Asp Thr Asp Met Trp Gly Asn Leu Pro Gly Gly Asp Gln Ser 
1               5                   10                  15      


Asn Ser Asn Leu Pro Thr Val Asp Arg Leu Thr Ala Leu Gly Ala Val 
            20                  25                  30          


Pro Gly Met Val Trp Gln Asn Arg Asp Ile 
        35                  40          


<210>  77
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus


<220>
<221>  SITE
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  SITE
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  77

Pro Val Ala Thr Glu Xaa Tyr Gly Val Val Ala Xaa Asn Leu Gln Ser 
1               5                   10                  15      


Ser Asn Thr Ala Pro Xaa Thr Gly Xaa Val Asn Ser Gln Gly Ala Leu 
            20                  25                  30          


Pro Gly Met Val Trp Gln Asn Arg Asp Val 
        35                  40          


<210>  78
<211>  240
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  78

Thr Phe Ser Tyr Thr Phe Glu Glu Val Pro Phe His Ser Ser Tyr Ala 
1               5                   10                  15      


His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr 
            20                  25                  30          


Leu Tyr Tyr Leu Asn Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn 
        35                  40                  45              


Lys Asp Leu Leu Phe Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln 
    50                  55                  60                  


Pro Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser 
65                  70                  75                  80  


Lys Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala 
                85                  90                  95      


Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr 
            100                 105                 110         


Ala Met Ala Ser His Lys Asp Asp Glu Asp Lys Phe Phe Pro Met Ser 
        115                 120                 125             


Gly Val Met Ile Phe Gly Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala 
    130                 135                 140                 


Leu Asp Asn Val Met Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn 
145                 150                 155                 160 


Pro Val Ala Thr Glu Arg Phe Gly Thr Val Ala Val Asn Phe Gln Ser 
                165                 170                 175     


Ser Ser Thr Asp Pro Ala Thr Gly Asp Val His Ala Met Gly Ala Leu 
            180                 185                 190         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        195                 200                 205             


Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
    210                 215                 220                 


Met Gly Gly Phe Gly Leu Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys 
225                 230                 235                 240 


<210>  79
<211>  240
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  79

Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala 
1               5                   10                  15      


His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr 
            20                  25                  30          


Leu Tyr Tyr Leu Asn Arg Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn 
        35                  40                  45              


Lys Asp Leu Leu Phe Ser Arg Gly Ser Pro Ala Gly Met Ser Val Gln 
    50                  55                  60                  


Pro Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser 
65                  70                  75                  80  


Lys Thr Lys Thr Asp Asn Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala 
                85                  90                  95      


Ser Lys Tyr Asn Leu Asn Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr 
            100                 105                 110         


Ala Met Ala Ser His Lys Asp Asp Lys Asp Lys Phe Phe Pro Met Ser 
        115                 120                 125             


Gly Val Met Ile Phe Gly Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala 
    130                 135                 140                 


Leu Asp Asn Val Met Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn 
145                 150                 155                 160 


Pro Val Ala Thr Glu Arg Phe Gly Thr Val Ala Val Asn Leu Gln Ser 
                165                 170                 175     


Ser Ser Thr Asp Pro Ala Thr Gly Asp Val His Val Met Gly Ala Leu 
            180                 185                 190         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        195                 200                 205             


Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
    210                 215                 220                 


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
225                 230                 235                 240 


<210>  80
<211>  240
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  80

Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His 
1               5                   10                  15      


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu 
            20                  25                  30          


Tyr Tyr Leu Asn Arg Thr Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln 
        35                  40                  45              


Ser Arg Leu Leu Phe Ser Gln Ala Gly Pro Gln Ser Met Ser Leu Gln 
    50                  55                  60                  


Ala Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser 
65                  70                  75                  80  


Lys Thr Ala Asn Asp Asn Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala 
                85                  90                  95      


Ser Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro 
            100                 105                 110         


Ala Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Met His 
        115                 120                 125             


Gly Asn Leu Ile Phe Gly Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu 
    130                 135                 140                 


Leu Asp Asn Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn 
145                 150                 155                 160 


Pro Val Ala Thr Glu Gln Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser 
                165                 170                 175     


Ser Asn Thr Ala Pro Thr Thr Gly Thr Val Asn His Gln Gly Ala Leu 
            180                 185                 190         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        195                 200                 205             


Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
    210                 215                 220                 


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Met Ile Lys 
225                 230                 235                 240 


<210>  81
<211>  240
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  81

Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His 
1               5                   10                  15      


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu 
            20                  25                  30          


Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser 
        35                  40                  45              


Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser 
    50                  55                  60                  


Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys 
65                  70                  75                  80  


Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr 
                85                  90                  95      


Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala 
            100                 105                 110         


Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly 
        115                 120                 125             


Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile 
    130                 135                 140                 


Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro 
145                 150                 155                 160 


Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly 
                165                 170                 175     


Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro 
            180                 185                 190         


Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        195                 200                 205             


Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met 
    210                 215                 220                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn 
225                 230                 235                 240 


<210>  82
<211>  243
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  82

Asn Phe Gln Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser 
1               5                   10                  15      


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            20                  25                  30          


Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala 
        35                  40                  45              


Asn Thr Gln Thr Leu Gly Phe Ser Gln Gly Gly Pro Asn Thr Met Ala 
    50                  55                  60                  


Asn Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg 
65                  70                  75                  80  


Val Ser Thr Thr Thr Gly Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr 
                85                  90                  95      


Ala Gly Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro 
            100                 105                 110         


Gly Ile Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro 
        115                 120                 125             


Ser Asn Gly Ile Leu Ile Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn 
    130                 135                 140                 


Ala Asp Tyr Ser Asp Val Met Leu Thr Ser Glu Glu Glu Ile Lys Thr 
145                 150                 155                 160 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu 
                165                 170                 175     


Gln Gln Gln Asn Thr Ala Pro Gln Ile Gly Thr Val Asn Ser Gln Gly 
            180                 185                 190         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        195                 200                 205             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    210                 215                 220                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
225                 230                 235                 240 


Ile Lys Asn 
            


<210>  83
<211>  243
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  83

Asn Phe Gln Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser 
1               5                   10                  15      


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            20                  25                  30          


Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala 
        35                  40                  45              


Asn Thr Gln Thr Leu Gly Phe Ser Gln Gly Gly Pro Asn Thr Met Ala 
    50                  55                  60                  


Asn Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg 
65                  70                  75                  80  


Val Ser Thr Thr Thr Gly Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr 
                85                  90                  95      


Ala Gly Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro 
            100                 105                 110         


Gly Ile Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro 
        115                 120                 125             


Ser Asn Gly Ile Leu Ile Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn 
    130                 135                 140                 


Ala Asp Tyr Ser Asp Val Met Leu Thr Ser Glu Glu Glu Ile Lys Thr 
145                 150                 155                 160 


Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu 
                165                 170                 175     


Gln Gly Gln Arg Gln Ala Ala Gln Ile Gly Thr Val Asn Ser Gln Gly 
            180                 185                 190         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        195                 200                 205             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    210                 215                 220                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
225                 230                 235                 240 


Ile Lys Asn 
            


<210>  84
<211>  241
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  84

Phe Gln Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr 
1               5                   10                  15      


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            20                  25                  30          


Tyr Leu Tyr Tyr Leu Val Arg Thr Gln Thr Thr Gly Thr Gly Gly Thr 
        35                  40                  45              


Gln Thr Leu Ala Phe Ser Gln Ala Gly Pro Ser Ser Met Ala Asn Gln 
    50                  55                  60                  


Ala Arg Asn Trp Val Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser 
65                  70                  75                  80  


Thr Thr Thr Asn Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala 
                85                  90                  95      


Ala Lys Phe Lys Leu Asn Gly Arg Asp Ser Leu Met Asn Pro Gly Val 
            100                 105                 110         


Ala Met Ala Ser His Lys Asp Asp Asp Asp Arg Phe Phe Pro Ser Ser 
        115                 120                 125             


Gly Val Leu Ile Phe Gly Lys Gln Gly Ala Gly Asn Asp Gly Val Asp 
    130                 135                 140                 


Tyr Ser Gln Val Leu Ile Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn 
145                 150                 155                 160 


Pro Val Ala Thr Glu Glu Tyr Gly Ala Val Ala Ile Asn Asn Gln Ala 
                165                 170                 175     


Ala Asn Thr Gln Ala Gln Thr Gly Leu Val His Asn Gln Gly Val Ile 
            180                 185                 190         


Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        195                 200                 205             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    210                 215                 220                 


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
225                 230                 235                 240 


Asn 
    


<210>  85
<211>  243
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  85

Asn Phe Glu Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser 
1               5                   10                  15      


Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp 
            20                  25                  30          


Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln 
        35                  40                  45              


Gly Thr Gln Gln Leu Leu Phe Ser Gln Ala Gly Pro Ala Asn Met Ser 
    50                  55                  60                  


Ala Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg 
65                  70                  75                  80  


Val Ser Thr Thr Leu Ser Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr 
                85                  90                  95      


Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro 
            100                 105                 110         


Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro 
        115                 120                 125             


Ser Ser Gly Val Leu Met Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn 
    130                 135                 140                 


Val Asp Tyr Ser Ser Val Met Leu Thr Ser Glu Glu Glu Ile Lys Thr 
145                 150                 155                 160 


Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly Val Val Ala Asp Asn Leu 
                165                 170                 175     


Gln Gln Ala Asn Thr Gly Pro Ile Val Gly Asn Val Asn Ser Gln Gly 
            180                 185                 190         


Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly 
        195                 200                 205             


Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser 
    210                 215                 220                 


Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu 
225                 230                 235                 240 


Ile Lys Asn 
            


<210>  86
<211>  242
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  86

Phe Glu Phe Ser Tyr Ser Phe Glu Asp Val Pro Phe His Ser Ser Tyr 
1               5                   10                  15      


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            20                  25                  30          


Tyr Leu Tyr Tyr Leu Ala Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala 
        35                  40                  45              


Gly Asn Arg Glu Leu Gln Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala 
    50                  55                  60                  


Glu Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg 
65                  70                  75                  80  


Val Ser Lys Thr Leu Asp Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr 
                85                  90                  95      


Gly Ala Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Val Asn Pro 
            100                 105                 110         


Gly Val Ala Met Ala Thr His Lys Asp Asp Glu Asp Arg Phe Phe Pro 
        115                 120                 125             


Ser Ser Gly Val Leu Ile Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr 
    130                 135                 140                 


Thr Leu Glu Asn Val Leu Met Thr Asn Glu Glu Glu Ile Arg Pro Thr 
145                 150                 155                 160 


Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln 
                165                 170                 175     


Ala Ala Asn Thr Ala Ala Gln Thr Gln Val Val Asn Asn Gln Gly Ala 
            180                 185                 190         


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro 
        195                 200                 205             


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
    210                 215                 220                 


Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile 
225                 230                 235                 240 


Lys Asn 
        


<210>  87
<211>  240
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  87

Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
1               5                   10                  15      


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            20                  25                  30          


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
        35                  40                  45              


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
    50                  55                  60                  


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
65                  70                  75                  80  


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
                85                  90                  95      


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
            100                 105                 110         


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
        115                 120                 125             


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
    130                 135                 140                 


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
145                 150                 155                 160 


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
                165                 170                 175     


Ala Gln Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            180                 185                 190         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        195                 200                 205             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    210                 215                 220                 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
225                 230                 235                 240 


<210>  88
<211>  240
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  88

Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr 
1               5                   10                  15      


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
            20                  25                  30          


Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln 
        35                  40                  45              


Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln 
    50                  55                  60                  


Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser 
65                  70                  75                  80  


Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala 
                85                  90                  95      


Ser Ser Trp Ala Leu Asn Gly Arg Asn Ser Leu Met Asn Pro Gly Pro 
            100                 105                 110         


Ala Met Ala Ser His Lys Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser 
        115                 120                 125             


Gly Ser Leu Ile Phe Gly Lys Gln Gly Thr Gly Arg Asp Asn Val Asp 
    130                 135                 140                 


Ala Asp Lys Val Met Ile Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn 
145                 150                 155                 160 


Pro Val Ala Thr Glu Ser Tyr Gly Gln Val Ala Thr Asn His Gln Ser 
                165                 170                 175     


Gly Gln Ala Gln Ala Ala Thr Gly Trp Val Gln Asn Gln Gly Ile Leu 
            180                 185                 190         


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
        195                 200                 205             


Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu 
    210                 215                 220                 


Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
225                 230                 235                 240 


<210>  89
<211>  240
<212>  PRT
<213>  Unknown

<220>
<223>  Virus of the Parvoviridae family and Dependovirus genus

<400>  89

Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
1               5                   10                  15      


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            20                  25                  30          


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        35                  40                  45              


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    50                  55                  60                  


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
65                  70                  75                  80  


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                85                  90                  95      


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            100                 105                 110         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        115                 120                 125             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    130                 135                 140                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
145                 150                 155                 160 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                165                 170                 175     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            180                 185                 190         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        195                 200                 205             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    210                 215                 220                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
225                 230                 235                 240 


<210>  90
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ser Arg Lys Ile Glu Gly Phe Leu Leu Leu Leu Leu Phe Gly Tyr 
1               5                   10                  15      


Glu Ala Thr Leu Gly Leu Ser Ser Thr Glu Asp Glu Gly Glu Asp Pro 
            20                  25                  30          


Trp Tyr Gln Lys Ala Cys Lys Cys Asp Cys Gln Gly Gly Pro Asn Ala 
        35                  40                  45              


Leu Trp Ser Ala Gly Ala Thr Ser Leu Asp Cys Ile Pro Glu Cys Pro 
    50                  55                  60                  


Tyr His Lys Pro Leu Gly Phe Glu Ser Gly Glu Val Thr Pro Asp Gln 
65                  70                  75                  80  


Ile Thr Cys Ser Asn Pro Glu Gln Tyr Val Gly Trp Tyr Ser Ser Trp 
                85                  90                  95      


Thr Ala Asn Lys Ala Arg Leu Asn Ser Gln Gly Phe Gly Cys Ala Trp 
            100                 105                 110         


Leu Ser Lys Phe Gln Asp Ser Ser Gln Trp Leu Gln Ile Asp Leu Lys 
        115                 120                 125             


Glu Ile Lys Val Ile Ser Gly Ile Leu Thr Gln Gly Arg Cys Asp Ile 
    130                 135                 140                 


Asp Glu Trp Met Thr Lys Tyr Ser Val Gln Tyr Arg Thr Asp Glu Arg 
145                 150                 155                 160 


Leu Asn Trp Ile Tyr Tyr Lys Asp Gln Thr Gly Asn Asn Arg Val Phe 
                165                 170                 175     


Tyr Gly Asn Ser Asp Arg Thr Ser Thr Val Gln Asn Leu Leu Arg Pro 
            180                 185                 190         


Pro Ile Ile Ser Arg Phe Ile Arg Leu Ile Pro Leu Gly Trp His Val 
        195                 200                 205             


Arg Ile Ala Ile Arg Met Glu Leu Leu Glu Cys Val Ser Lys Cys Ala 
    210                 215                 220                 


<210>  91
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp His Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Met Val Leu Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  92
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ser Ile Gln Val Glu His Pro Ala Gly Gly Tyr Lys Lys Leu Phe 
1               5                   10                  15      


Glu Thr Val Glu Glu Leu Ser Ser Pro Leu Thr Ala His Val Thr Gly 
            20                  25                  30          


Arg Ile Pro Leu Trp Leu Thr Gly Ser Leu Leu Arg Cys Gly Pro Gly 
        35                  40                  45              


Leu Phe Glu Val Gly Ser Glu Pro Phe Tyr His Leu Phe Asp Gly Gln 
    50                  55                  60                  


Ala Leu Leu His Lys Phe Asp Phe Lys Glu Gly His Val Thr Tyr His 
65                  70                  75                  80  


Arg Arg Phe Ile Arg Thr Asp Ala Tyr Val Arg Ala Met Thr Glu Lys 
                85                  90                  95      


Arg Ile Val Ile Thr Glu Phe Gly Thr Cys Ala Phe Pro Asp Pro Cys 
            100                 105                 110         


Lys Asn Ile Phe Ser Arg Phe Phe Ser Tyr Phe Arg Gly Val Glu Val 
        115                 120                 125             


Thr Asp Asn Ala Leu Val Asn Val Tyr Pro Val Gly Glu Asp Tyr Tyr 
    130                 135                 140                 


Ala Cys Thr Glu Thr Asn Phe Ile Thr Lys Ile Asn Pro Glu Thr Leu 
145                 150                 155                 160 


Glu Thr Ile Lys Gln Val Asp Leu Cys Asn Tyr Val Ser Val Asn Gly 
                165                 170                 175     


Ala Thr Ala His Pro His Ile Glu Asn Asp Gly Thr Val Tyr Asn Ile 
            180                 185                 190         


Gly Asn Cys Phe Gly Lys Asn Phe Ser Ile Ala Tyr Asn Ile Val Lys 
        195                 200                 205             


Ile Pro Pro Leu Gln Ala Asp Lys Glu Asp Pro Ile Ser Lys Ser Glu 
    210                 215                 220                 


Ile Val Val Gln Phe Pro Cys Ser Asp Arg Phe Lys Pro Ser Tyr Val 
225                 230                 235                 240 


His Ser Phe Gly Leu Thr Pro Asn Tyr Ile Val Phe Val Glu Thr Pro 
                245                 250                 255     


Val Lys Ile Asn Leu Phe Lys Phe Leu Ser Ser Trp Ser Leu Trp Gly 
            260                 265                 270         


Ala Asn Tyr Met Asp Cys Phe Glu Ser Asn Glu Thr Met Gly Val Trp 
        275                 280                 285             


Leu His Ile Ala Asp Lys Lys Arg Lys Lys Tyr Leu Asn Asn Lys Tyr 
    290                 295                 300                 


Arg Thr Ser Pro Phe Asn Leu Phe His His Ile Asn Thr Tyr Glu Asp 
305                 310                 315                 320 


Asn Gly Phe Leu Ile Val Asp Leu Cys Cys Trp Lys Gly Phe Glu Phe 
                325                 330                 335     


Val Tyr Asn Tyr Leu Tyr Leu Ala Asn Leu Arg Glu Asn Trp Glu Glu 
            340                 345                 350         


Val Lys Lys Asn Ala Arg Lys Ala Pro Gln Pro Glu Val Arg Arg Tyr 
        355                 360                 365             


Val Leu Pro Leu Asn Ile Asp Lys Ala Asp Thr Gly Lys Asn Leu Val 
    370                 375                 380                 


Thr Leu Pro Asn Thr Thr Ala Thr Ala Ile Leu Cys Ser Asp Glu Thr 
385                 390                 395                 400 


Ile Trp Leu Glu Pro Glu Val Leu Phe Ser Gly Pro Arg Gln Ala Phe 
                405                 410                 415     


Glu Phe Pro Gln Ile Asn Tyr Gln Lys Tyr Cys Gly Lys Pro Tyr Thr 
            420                 425                 430         


Tyr Ala Tyr Gly Leu Gly Leu Asn His Phe Val Pro Asp Arg Leu Cys 
        435                 440                 445             


Lys Leu Asn Val Lys Thr Lys Glu Thr Trp Val Trp Gln Glu Pro Asp 
    450                 455                 460                 


Ser Tyr Pro Ser Glu Pro Ile Phe Val Ser His Pro Asp Ala Leu Glu 
465                 470                 475                 480 


Glu Asp Asp Gly Val Val Leu Ser Val Val Val Ser Pro Gly Ala Gly 
                485                 490                 495     


Gln Lys Pro Ala Tyr Leu Leu Ile Leu Asn Ala Lys Asp Leu Ser Glu 
            500                 505                 510         


Val Ala Arg Ala Glu Val Glu Ile Asn Ile Pro Val Thr Phe His Gly 
        515                 520                 525             


Leu Phe Lys Lys Ser 
    530             


<210>  93
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Ala Leu Leu Lys Val Lys Phe Asp Gln Lys Lys Arg Val Lys Leu 
1               5                   10                  15      


Ala Gln Gly Leu Trp Leu Met Asn Trp Phe Ser Val Leu Ala Gly Ile 
            20                  25                  30          


Ile Ile Phe Ser Leu Gly Leu Phe Leu Lys Ile Glu Leu Arg Lys Arg 
        35                  40                  45              


Ser Asp Val Met Asn Asn Ser Glu Ser His Phe Val Pro Asn Ser Leu 
    50                  55                  60                  


Ile Gly Met Gly Val Leu Ser Cys Val Phe Asn Ser Leu Ala Gly Lys 
65                  70                  75                  80  


Ile Cys Tyr Asp Ala Leu Asp Pro Ala Lys Tyr Ala Arg Trp Lys Pro 
                85                  90                  95      


Trp Leu Lys Pro Tyr Leu Ala Ile Cys Val Leu Phe Asn Ile Ile Leu 
            100                 105                 110         


Phe Leu Val Ala Leu Cys Cys Phe Leu Leu Arg Gly Ser Leu Glu Asn 
        115                 120                 125             


Thr Leu Gly Gln Gly Leu Lys Asn Gly Met Lys Tyr Tyr Arg Asp Thr 
    130                 135                 140                 


Asp Thr Pro Gly Arg Cys Phe Met Lys Lys Thr Ile Asp Met Leu Gln 
145                 150                 155                 160 


Ile Glu Phe Lys Cys Cys Gly Asn Asn Gly Phe Arg Asp Trp Phe Glu 
                165                 170                 175     


Ile Gln Trp Ile Ser Asn Arg Tyr Leu Asp Phe Ser Ser Lys Glu Val 
            180                 185                 190         


Lys Asp Arg Ile Lys Ser Asn Val Asp Gly Arg Tyr Leu Val Asp Gly 
        195                 200                 205             


Val Pro Phe Ser Cys Cys Asn Pro Ser Ser Pro Arg Pro Cys Ile Gln 
    210                 215                 220                 


Tyr Gln Ile Thr Asn Asn Ser Ala His Tyr Ser Tyr Asp His Gln Thr 
225                 230                 235                 240 


Glu Glu Leu Asn Leu Trp Val Arg Gly Cys Arg Ala Ala Leu Leu Ser 
                245                 250                 255     


Tyr Tyr Ser Ser Leu Met Asn Ser Met Gly Val Val Thr Leu Leu Ile 
            260                 265                 270         


Trp Leu Phe Glu Val Thr Ile Thr Ile Gly Leu Arg Tyr Leu Gln Thr 
        275                 280                 285             


Ser Leu Asp Gly Val Ser Asn Pro Glu Glu Ser Glu Ser Glu Ser Gln 
    290                 295                 300                 


Gly Trp Leu Leu Glu Arg Ser Val Pro Glu Thr Trp Lys Ala Phe Leu 
305                 310                 315                 320 


Glu Ser Val Lys Lys Leu Gly Lys Gly Asn Gln Val Glu Ala Glu Gly 
                325                 330                 335     


Ala Asp Ala Gly Gln Ala Pro Glu Ala Gly 
            340                 345     


<210>  94
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ser His His Pro Ser Gly Leu Arg Ala Gly Phe Ser Ser Thr Ser 
1               5                   10                  15      


Tyr Arg Arg Thr Phe Gly Pro Pro Pro Ser Leu Ser Pro Gly Ala Phe 
            20                  25                  30          


Ser Tyr Ser Ser Ser Ser Arg Phe Ser Ser Ser Arg Leu Leu Gly Ser 
        35                  40                  45              


Ala Ser Pro Ser Ser Ser Val Arg Leu Gly Ser Phe Arg Ser Pro Arg 
    50                  55                  60                  


Ala Gly Ala Gly Ala Leu Leu Arg Leu Pro Ser Glu Arg Leu Asp Phe 
65                  70                  75                  80  


Ser Met Ala Glu Ala Leu Asn Gln Glu Phe Leu Ala Thr Arg Ser Asn 
                85                  90                  95      


Glu Lys Gln Glu Leu Gln Glu Leu Asn Asp Arg Phe Ala Asn Phe Ile 
            100                 105                 110         


Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Ala Ala Leu Arg Gly Glu 
        115                 120                 125             


Leu Ser Gln Ala Arg Gly Gln Glu Pro Ala Arg Ala Asp Gln Leu Cys 
    130                 135                 140                 


Gln Gln Glu Leu Arg Glu Leu Arg Arg Glu Leu Glu Leu Leu Gly Arg 
145                 150                 155                 160 


Glu Arg Asp Arg Val Gln Val Glu Arg Asp Gly Leu Ala Glu Asp Leu 
                165                 170                 175     


Ala Ala Leu Lys Gln Arg Leu Glu Glu Glu Thr Arg Lys Arg Glu Asp 
            180                 185                 190         


Ala Glu His Asn Leu Val Leu Phe Arg Lys Asp Val Asp Asp Ala Thr 
        195                 200                 205             


Leu Ser Arg Leu Glu Leu Glu Arg Lys Ile Glu Ser Leu Met Asp Glu 
    210                 215                 220                 


Ile Glu Phe Leu Lys Lys Leu His Glu Glu Glu Leu Arg Asp Leu Gln 
225                 230                 235                 240 


Val Ser Val Glu Ser Gln Gln Val Gln Gln Val Glu Val Glu Ala Thr 
                245                 250                 255     


Val Lys Pro Glu Leu Thr Ala Ala Leu Arg Asp Ile Arg Ala Gln Tyr 
            260                 265                 270         


Glu Ser Ile Ala Ala Lys Asn Leu Gln Glu Ala Glu Glu Trp Tyr Lys 
        275                 280                 285             


Ser Lys Tyr Ala Asp Leu Ser Asp Ala Ala Asn Arg Asn His Glu Ala 
    290                 295                 300                 


Leu Arg Gln Ala Lys Gln Glu Met Asn Glu Ser Arg Arg Gln Ile Gln 
305                 310                 315                 320 


Ser Leu Thr Cys Glu Val Asp Gly Leu Arg Gly Thr Asn Glu Ala Leu 
                325                 330                 335     


Leu Arg Gln Leu Arg Glu Leu Glu Glu Gln Phe Ala Leu Glu Ala Gly 
            340                 345                 350         


Gly Tyr Gln Ala Gly Ala Ala Arg Leu Glu Glu Glu Leu Arg Gln Leu 
        355                 360                 365             


Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln Glu Leu Leu Asn 
    370                 375                 380                 


Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu 
385                 390                 395                 400 


Glu Gly Glu Glu Ser Arg Ile Ser Val Pro Val His Ser Phe Ala Ser 
                405                 410                 415     


Leu Asn Ile Lys Thr Thr Val Pro Glu Val Glu Pro Pro Gln Asp Ser 
            420                 425                 430         


His Ser Arg Lys Thr Val Leu Ile Lys Thr Ile Glu Thr Arg Asn Gly 
        435                 440                 445             


Glu Val Val Thr Glu Ser Gln Lys Glu Gln Arg Ser Glu Leu Asp Lys 
    450                 455                 460                 


Ser Ser Ala His Ser Tyr 
465                 470 


<210>  95
<211>  1286
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ser His Leu Val Asp Pro Thr Ser Gly Asp Leu Pro Val Arg Asp 
1               5                   10                  15      


Ile Asp Ala Ile Pro Leu Val Leu Pro Ala Ser Lys Gly Lys Asn Met 
            20                  25                  30          


Lys Thr Gln Pro Pro Leu Ser Arg Met Asn Arg Glu Glu Leu Glu Asp 
        35                  40                  45              


Ser Phe Phe Arg Leu Arg Glu Asp His Met Leu Val Lys Glu Leu Ser 
    50                  55                  60                  


Trp Lys Gln Gln Asp Glu Ile Lys Arg Leu Arg Thr Thr Leu Leu Arg 
65                  70                  75                  80  


Leu Thr Ala Ala Gly Arg Asp Leu Arg Val Ala Glu Glu Ala Ala Pro 
                85                  90                  95      


Leu Ser Glu Thr Ala Arg Arg Gly Gln Lys Ala Gly Trp Arg Gln Arg 
            100                 105                 110         


Leu Ser Met His Gln Arg Pro Gln Met His Arg Leu Gln Gly His Phe 
        115                 120                 125             


His Cys Val Gly Pro Ala Ser Pro Arg Arg Ala Gln Pro Arg Val Gln 
    130                 135                 140                 


Val Gly His Arg Gln Leu His Thr Ala Gly Ala Pro Val Pro Glu Lys 
145                 150                 155                 160 


Pro Lys Arg Gly Pro Arg Asp Arg Leu Ser Tyr Thr Ala Pro Pro Ser 
                165                 170                 175     


Phe Lys Glu His Ala Thr Asn Glu Asn Arg Gly Glu Val Ala Ser Lys 
            180                 185                 190         


Pro Ser Glu Leu Val Ser Gly Ser Asn Ser Ile Ile Ser Phe Ser Ser 
        195                 200                 205             


Val Ile Ser Met Ala Lys Pro Ile Gly Leu Cys Met Pro Asn Ser Ala 
    210                 215                 220                 


His Ile Met Ala Ser Asn Thr Met Gln Val Glu Glu Pro Pro Lys Ser 
225                 230                 235                 240 


Pro Glu Lys Met Trp Pro Lys Asp Glu Asn Phe Glu Gln Arg Ser Ser 
                245                 250                 255     


Leu Glu Cys Ala Gln Lys Ala Ala Glu Leu Arg Ala Ser Ile Lys Glu 
            260                 265                 270         


Lys Val Glu Leu Ile Arg Leu Lys Lys Leu Leu His Glu Arg Asn Ala 
        275                 280                 285             


Ser Leu Val Met Thr Lys Ala Gln Leu Thr Glu Val Gln Glu Ala Tyr 
    290                 295                 300                 


Glu Thr Leu Leu Gln Lys Asn Gln Gly Ile Leu Ser Ala Ala His Glu 
305                 310                 315                 320 


Ala Leu Leu Lys Gln Val Asn Glu Leu Arg Ala Glu Leu Lys Glu Glu 
                325                 330                 335     


Ser Lys Lys Ala Val Ser Leu Lys Ser Gln Leu Glu Asp Val Ser Ile 
            340                 345                 350         


Leu Gln Met Thr Leu Lys Glu Phe Gln Glu Arg Val Glu Asp Leu Glu 
        355                 360                 365             


Lys Glu Arg Lys Leu Leu Asn Asp Asn Tyr Asp Lys Leu Leu Glu Ser 
    370                 375                 380                 


Met Leu Asp Ser Ser Asp Ser Ser Ser Gln Pro His Trp Ser Asn Glu 
385                 390                 395                 400 


Leu Ile Ala Glu Gln Leu Gln Gln Gln Val Ser Gln Leu Gln Asp Gln 
                405                 410                 415     


Leu Asp Ala Glu Leu Glu Asp Lys Arg Lys Val Leu Leu Glu Leu Ser 
            420                 425                 430         


Arg Glu Lys Ala Gln Asn Glu Asp Leu Lys Leu Glu Val Thr Asn Ile 
        435                 440                 445             


Leu Gln Lys His Lys Gln Glu Val Glu Leu Leu Gln Asn Ala Ala Thr 
    450                 455                 460                 


Ile Ser Gln Pro Pro Asp Arg Gln Ser Glu Pro Ala Thr His Pro Ala 
465                 470                 475                 480 


Val Leu Gln Glu Asn Thr Gln Ile Glu Pro Ser Glu Pro Lys Asn Gln 
                485                 490                 495     


Glu Glu Lys Lys Leu Ser Gln Val Leu Asn Glu Leu Gln Val Ser His 
            500                 505                 510         


Ala Glu Thr Thr Leu Glu Leu Glu Lys Thr Arg Asp Met Leu Ile Leu 
        515                 520                 525             


Gln Arg Lys Ile Asn Val Cys Tyr Gln Glu Glu Leu Glu Ala Met Met 
    530                 535                 540                 


Thr Lys Ala Asp Asn Asp Asn Arg Asp His Lys Glu Lys Leu Glu Arg 
545                 550                 555                 560 


Leu Thr Arg Leu Leu Asp Leu Lys Asn Asn Arg Ile Lys Gln Leu Glu 
                565                 570                 575     


Gly Ile Leu Arg Ser His Asp Leu Pro Thr Ser Glu Gln Leu Lys Asp 
            580                 585                 590         


Val Ala Tyr Gly Thr Arg Pro Leu Ser Leu Cys Leu Glu Thr Leu Pro 
        595                 600                 605             


Ala His Gly Asp Glu Asp Lys Val Asp Ile Ser Leu Leu His Gln Gly 
    610                 615                 620                 


Glu Asn Leu Phe Glu Leu His Ile His Gln Ala Phe Leu Thr Ser Ala 
625                 630                 635                 640 


Ala Leu Ala Gln Ala Gly Asp Thr Gln Pro Thr Thr Phe Cys Thr Tyr 
                645                 650                 655     


Ser Phe Tyr Asp Phe Glu Thr His Cys Thr Pro Leu Ser Val Gly Pro 
            660                 665                 670         


Gln Pro Leu Tyr Asp Phe Thr Ser Gln Tyr Val Met Glu Thr Asp Ser 
        675                 680                 685             


Leu Phe Leu His Tyr Leu Gln Glu Ala Ser Ala Arg Leu Asp Ile His 
    690                 695                 700                 


Gln Ala Met Ala Ser Glu His Ser Thr Leu Ala Ala Gly Trp Ile Cys 
705                 710                 715                 720 


Phe Asp Arg Val Leu Glu Thr Val Glu Lys Val His Gly Leu Ala Thr 
                725                 730                 735     


Leu Ile Gly Ala Gly Gly Glu Glu Phe Gly Val Leu Glu Tyr Trp Met 
            740                 745                 750         


Arg Leu Arg Phe Pro Ile Lys Pro Ser Leu Gln Ala Cys Asn Lys Arg 
        755                 760                 765             


Lys Lys Ala Gln Val Tyr Leu Ser Thr Asp Val Leu Gly Gly Arg Lys 
    770                 775                 780                 


Ala Gln Glu Glu Glu Phe Arg Ser Glu Ser Trp Glu Pro Gln Asn Glu 
785                 790                 795                 800 


Leu Trp Ile Glu Ile Thr Lys Cys Cys Gly Leu Arg Ser Arg Trp Leu 
                805                 810                 815     


Gly Thr Gln Pro Ser Pro Tyr Ala Val Tyr Arg Phe Phe Thr Phe Ser 
            820                 825                 830         


Asp His Asp Thr Ala Ile Ile Pro Ala Ser Asn Asn Pro Tyr Phe Arg 
        835                 840                 845             


Asp Gln Ala Arg Phe Pro Val Leu Val Thr Ser Asp Leu Asp His Tyr 
    850                 855                 860                 


Leu Arg Arg Glu Ala Leu Ser Ile His Val Phe Asp Asp Glu Asp Leu 
865                 870                 875                 880 


Glu Pro Gly Ser Tyr Leu Gly Arg Ala Arg Val Pro Leu Leu Pro Leu 
                885                 890                 895     


Ala Lys Asn Glu Ser Ile Lys Gly Asp Phe Asn Leu Thr Asp Pro Ala 
            900                 905                 910         


Glu Lys Pro Asn Gly Ser Ile Gln Val Gln Leu Asp Trp Lys Phe Pro 
        915                 920                 925             


Tyr Ile Pro Pro Glu Ser Phe Leu Lys Pro Glu Ala Gln Thr Lys Gly 
    930                 935                 940                 


Lys Asp Thr Lys Asp Ser Ser Lys Ile Ser Ser Glu Glu Glu Lys Ala 
945                 950                 955                 960 


Ser Phe Pro Ser Gln Asp Gln Met Ala Ser Pro Glu Val Pro Ile Glu 
                965                 970                 975     


Ala Gly Gln Tyr Arg Ser Lys Arg Lys Pro Pro His Gly Gly Glu Arg 
            980                 985                 990         


Lys Glu Lys Glu His Gln Val Val  Ser Tyr Ser Arg Arg  Lys His Gly 
        995                 1000                 1005             


Lys Arg  Ile Gly Val Gln Gly  Lys Asn Arg Met Glu  Tyr Leu Ser 
    1010                 1015                 1020             


Leu Asn  Ile Leu Asn Gly Asn  Thr Pro Glu Gln Val  Asn Tyr Thr 
    1025                 1030                 1035             


Glu Trp  Lys Phe Ser Glu Thr  Asn Ser Phe Ile Gly  Asp Gly Phe 
    1040                 1045                 1050             


Lys Asn  Gln His Glu Glu Glu  Glu Met Thr Leu Ser  His Ser Ala 
    1055                 1060                 1065             


Leu Lys  Gln Lys Glu Pro Leu  His Pro Val Asn Asp  Lys Glu Ser 
    1070                 1075                 1080             


Ser Glu  Gln Gly Ser Glu Val  Ser Glu Ala Gln Thr  Thr Asp Ser 
    1085                 1090                 1095             


Asp Asp  Val Ile Val Pro Pro  Met Ser Gln Lys Tyr  Pro Lys Ala 
    1100                 1105                 1110             


Asp Ser  Glu Lys Met Cys Ile  Glu Ile Val Ser Leu  Ala Phe Tyr 
    1115                 1120                 1125             


Pro Glu  Ala Glu Val Met Ser  Asp Glu Asn Ile Lys  Gln Val Tyr 
    1130                 1135                 1140             


Val Glu  Tyr Lys Phe Tyr Asp  Leu Pro Leu Ser Glu  Thr Glu Thr 
    1145                 1150                 1155             


Pro Val  Ser Leu Arg Lys Pro  Arg Ala Gly Glu Glu  Ile His Phe 
    1160                 1165                 1170             


His Phe  Ser Lys Val Ile Asp  Leu Asp Pro Gln Glu  Gln Gln Gly 
    1175                 1180                 1185             


Arg Arg  Arg Phe Leu Phe Asp  Met Leu Asn Gly Gln  Asp Pro Asp 
    1190                 1195                 1200             


Gln Gly  His Leu Lys Phe Thr  Val Val Ser Asp Pro  Leu Asp Glu 
    1205                 1210                 1215             


Glu Lys  Lys Glu Cys Glu Glu  Val Gly Tyr Ala Tyr  Leu Gln Leu 
    1220                 1225                 1230             


Trp Gln  Ile Leu Glu Ser Gly  Arg Asp Ile Leu Glu  Gln Glu Leu 
    1235                 1240                 1245             


Asp Ile  Val Ser Pro Glu Asp  Leu Ala Thr Pro Ile  Gly Arg Leu 
    1250                 1255                 1260             


Lys Val  Ser Leu Gln Ala Ala  Ala Val Leu His Ala  Ile Tyr Lys 
    1265                 1270                 1275             


Glu Met  Thr Glu Asp Leu Phe  Ser 
    1280                 1285     


<210>  96
<211>  653
<212>  PRT
<213>  Unknown

<220>
<223>  Rab escort protein-1

<400>  96

Met Ala Asp Thr Leu Pro Ser Glu Phe Asp Val Ile Val Ile Gly Thr 
1               5                   10                  15      


Gly Leu Pro Glu Ser Ile Ile Ala Ala Ala Cys Ser Arg Ser Gly Arg 
            20                  25                  30          


Arg Val Leu His Val Asp Ser Arg Ser Tyr Tyr Gly Gly Asn Trp Ala 
        35                  40                  45              


Ser Phe Ser Phe Ser Gly Leu Leu Ser Trp Leu Lys Glu Tyr Gln Glu 
    50                  55                  60                  


Asn Ser Asp Ile Val Ser Asp Ser Pro Val Trp Gln Asp Gln Ile Leu 
65                  70                  75                  80  


Glu Asn Glu Glu Ala Ile Ala Leu Ser Arg Lys Asp Lys Thr Ile Gln 
                85                  90                  95      


His Val Glu Val Phe Cys Tyr Ala Ser Gln Asp Leu His Glu Asp Val 
            100                 105                 110         


Glu Glu Ala Gly Ala Leu Gln Lys Asn His Ala Leu Val Thr Ser Ala 
        115                 120                 125             


Asn Ser Thr Glu Ala Ala Asp Ser Ala Phe Leu Pro Thr Glu Asp Glu 
    130                 135                 140                 


Ser Leu Ser Thr Met Ser Cys Glu Met Leu Thr Glu Gln Thr Pro Ser 
145                 150                 155                 160 


Ser Asp Pro Glu Asn Ala Leu Glu Val Asn Gly Ala Glu Val Thr Gly 
                165                 170                 175     


Glu Lys Glu Asn His Cys Asp Asp Lys Thr Cys Val Pro Ser Thr Ser 
            180                 185                 190         


Ala Glu Asp Met Ser Glu Asn Val Pro Ile Ala Glu Asp Thr Thr Glu 
        195                 200                 205             


Gln Pro Lys Lys Asn Arg Ile Thr Tyr Ser Gln Ile Ile Lys Glu Gly 
    210                 215                 220                 


Arg Arg Phe Asn Ile Asp Leu Val Ser Lys Leu Leu Tyr Ser Arg Gly 
225                 230                 235                 240 


Leu Leu Ile Asp Leu Leu Ile Lys Ser Asn Val Ser Arg Tyr Ala Glu 
                245                 250                 255     


Phe Lys Asn Ile Thr Arg Ile Leu Ala Phe Arg Glu Gly Arg Val Glu 
            260                 265                 270         


Gln Val Pro Cys Ser Arg Ala Asp Val Phe Asn Ser Lys Gln Leu Thr 
        275                 280                 285             


Met Val Glu Lys Arg Met Leu Met Lys Phe Leu Thr Phe Cys Met Glu 
    290                 295                 300                 


Tyr Glu Lys Tyr Pro Asp Glu Tyr Lys Gly Tyr Glu Glu Ile Thr Phe 
305                 310                 315                 320 


Tyr Glu Tyr Leu Lys Thr Gln Lys Leu Thr Pro Asn Leu Gln Tyr Ile 
                325                 330                 335     


Val Met His Ser Ile Ala Met Thr Ser Glu Thr Ala Ser Ser Thr Ile 
            340                 345                 350         


Asp Gly Leu Lys Ala Thr Lys Asn Phe Leu His Cys Leu Gly Arg Tyr 
        355                 360                 365             


Gly Asn Thr Pro Phe Leu Phe Pro Leu Tyr Gly Gln Gly Glu Leu Pro 
    370                 375                 380                 


Gln Cys Phe Cys Arg Met Cys Ala Val Phe Gly Gly Ile Tyr Cys Leu 
385                 390                 395                 400 


Arg His Ser Val Gln Cys Leu Val Val Asp Lys Glu Ser Arg Lys Cys 
                405                 410                 415     


Lys Ala Ile Ile Asp Gln Phe Gly Gln Arg Ile Ile Ser Glu His Phe 
            420                 425                 430         


Leu Val Glu Asp Ser Tyr Phe Pro Glu Asn Met Cys Ser Arg Val Gln 
        435                 440                 445             


Tyr Arg Gln Ile Ser Arg Ala Val Leu Ile Thr Asp Arg Ser Val Leu 
    450                 455                 460                 


Lys Thr Asp Ser Asp Gln Gln Ile Ser Ile Leu Thr Val Pro Ala Glu 
465                 470                 475                 480 


Glu Pro Gly Thr Phe Ala Val Arg Val Ile Glu Leu Cys Ser Ser Thr 
                485                 490                 495     


Met Thr Cys Met Lys Gly Thr Tyr Leu Val His Leu Thr Cys Thr Ser 
            500                 505                 510         


Ser Lys Thr Ala Arg Glu Asp Leu Glu Ser Val Val Gln Lys Leu Phe 
        515                 520                 525             


Val Pro Tyr Thr Glu Met Glu Ile Glu Asn Glu Gln Val Glu Lys Pro 
    530                 535                 540                 


Arg Ile Leu Trp Ala Leu Tyr Phe Asn Met Arg Asp Ser Ser Asp Ile 
545                 550                 555                 560 


Ser Arg Ser Cys Tyr Asn Asp Leu Pro Ser Asn Val Tyr Val Cys Ser 
                565                 570                 575     


Gly Pro Asp Cys Gly Leu Gly Asn Asp Asn Ala Val Lys Gln Ala Glu 
            580                 585                 590         


Thr Leu Phe Gln Glu Ile Cys Pro Asn Glu Asp Phe Cys Pro Pro Pro 
        595                 600                 605             


Pro Asn Pro Glu Asp Ile Ile Leu Asp Gly Asp Ser Leu Gln Pro Glu 
    610                 615                 620                 


Ala Ser Glu Ser Ser Ala Ile Pro Glu Ala Asn Ser Glu Thr Phe Lys 
625                 630                 635                 640 


Glu Ser Thr Asn Leu Gly Asn Leu Glu Glu Ser Ser Glu 
                645                 650             


<210>  97
<211>  212
<212>  PRT
<213>  Unknown

<220>
<223>  amino acid isoform of RdCVF

<400>  97

Met Ala Ser Leu Phe Ser Gly Arg Ile Leu Ile Arg Asn Asn Ser Asp 
1               5                   10                  15      


Gln Asp Glu Leu Asp Thr Glu Ala Glu Val Ser Arg Arg Leu Glu Asn 
            20                  25                  30          


Arg Leu Val Leu Leu Phe Phe Gly Ala Gly Ala Cys Pro Gln Cys Gln 
        35                  40                  45              


Ala Phe Val Pro Ile Leu Lys Asp Phe Phe Val Arg Leu Thr Asp Glu 
    50                  55                  60                  


Phe Tyr Val Leu Arg Ala Ala Gln Leu Ala Leu Val Tyr Val Ser Gln 
65                  70                  75                  80  


Asp Ser Thr Glu Glu Gln Gln Asp Leu Phe Leu Lys Asp Met Pro Lys 
                85                  90                  95      


Lys Trp Leu Phe Leu Pro Phe Glu Asp Asp Leu Arg Arg Asp Leu Gly 
            100                 105                 110         


Arg Gln Phe Ser Val Glu Arg Leu Pro Ala Val Val Val Leu Lys Pro 
        115                 120                 125             


Asp Gly Asp Val Leu Thr Arg Asp Gly Ala Asp Glu Ile Gln Arg Leu 
    130                 135                 140                 


Gly Thr Ala Cys Phe Ala Asn Trp Gln Glu Ala Ala Glu Val Leu Asp 
145                 150                 155                 160 


Arg Asn Phe Gln Leu Pro Glu Asp Leu Glu Asp Gln Glu Pro Arg Ser 
                165                 170                 175     


Leu Thr Glu Cys Leu Arg Arg His Lys Tyr Arg Val Glu Lys Ala Ala 
            180                 185                 190         


Arg Gly Gly Arg Asp Pro Gly Gly Gly Gly Gly Glu Glu Gly Gly Ala 
        195                 200                 205             


Gly Gly Leu Phe 
    210         


<210>  98
<211>  156
<212>  PRT
<213>  Unknown

<220>
<223>  amino acid isoform of RdCVF (isoform 1)

<400>  98

Met Val Asp Ile Leu Gly Glu Arg His Leu Val Thr Cys Lys Gly Ala 
1               5                   10                  15      


Thr Val Glu Ala Glu Ala Ala Leu Gln Asn Lys Val Val Ala Leu Tyr 
            20                  25                  30          


Phe Ala Ala Ala Arg Cys Ala Pro Ser Arg Asp Phe Thr Pro Leu Leu 
        35                  40                  45              


Cys Asp Phe Tyr Thr Ala Leu Val Ala Glu Ala Arg Arg Pro Ala Pro 
    50                  55                  60                  


Phe Glu Val Val Phe Val Ser Ala Asp Gly Ser Ser Gln Glu Met Leu 
65                  70                  75                  80  


Asp Phe Met Arg Glu Leu His Gly Ala Trp Leu Ala Leu Pro Phe His 
                85                  90                  95      


Asp Pro Tyr Arg His Glu Leu Arg Lys Arg Tyr Asn Val Thr Ala Ile 
            100                 105                 110         


Pro Lys Leu Val Ile Val Lys Gln Asn Gly Glu Val Ile Thr Asn Lys 
        115                 120                 125             


Gly Arg Lys Gln Ile Arg Glu Arg Gly Leu Ala Cys Phe Gln Asp Trp 
    130                 135                 140                 


Val Glu Ala Ala Asp Ile Phe Gln Asn Phe Ser Val 
145                 150                 155     


<210>  99
<211>  135
<212>  PRT
<213>  Unknown

<220>
<223>  amino acid isoform of RdCVF (isoform 2)

<400>  99

Met Val Asp Ile Leu Gly Glu Arg His Leu Val Thr Cys Lys Gly Ala 
1               5                   10                  15      


Thr Val Glu Ala Glu Ala Ala Leu Gln Asn Lys Val Val Ala Leu Tyr 
            20                  25                  30          


Phe Ala Ala Ala Arg Cys Ala Pro Ser Arg Asp Phe Thr Pro Leu Leu 
        35                  40                  45              


Cys Asp Phe Tyr Thr Ala Leu Val Ala Glu Ala Arg Arg Pro Ala Pro 
    50                  55                  60                  


Phe Glu Val Val Phe Val Ser Ala Asp Gly Ser Ser Gln Glu Met Leu 
65                  70                  75                  80  


Asp Phe Met Arg Glu Leu His Gly Ala Trp Leu Ala Leu Pro Phe His 
                85                  90                  95      


Asp Pro Tyr Arg Gln Arg Ser Leu Ala Leu Leu Pro Arg Leu Glu Cys 
            100                 105                 110         


Ser Gly Val Ile Leu Ala His Cys Asn Leu Cys Leu Leu Gly Ser Ser 
        115                 120                 125             


Asp Ser Leu Ala Leu Ala Ser 
    130                 135 


<210>  100
<211>  860
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Gly Glu Val Thr Ala Glu Glu Val Glu Lys Phe Leu Asp Ser Asn 
1               5                   10                  15      


Ile Gly Phe Ala Lys Gln Tyr Tyr Asn Leu His Tyr Arg Ala Lys Leu 
            20                  25                  30          


Ile Ser Asp Leu Leu Gly Ala Lys Glu Ala Ala Val Asp Phe Ser Asn 
        35                  40                  45              


Tyr His Ser Pro Ser Ser Met Glu Glu Ser Glu Ile Ile Phe Asp Leu 
    50                  55                  60                  


Leu Arg Asp Phe Gln Glu Asn Leu Gln Thr Glu Lys Cys Ile Phe Asn 
65                  70                  75                  80  


Val Met Lys Lys Leu Cys Phe Leu Leu Gln Ala Asp Arg Met Ser Leu 
                85                  90                  95      


Phe Met Tyr Arg Thr Arg Asn Gly Ile Ala Glu Leu Ala Thr Arg Leu 
            100                 105                 110         


Phe Asn Val His Lys Asp Ala Val Leu Glu Asp Cys Leu Val Met Pro 
        115                 120                 125             


Asp Gln Glu Ile Val Phe Pro Leu Asp Met Gly Ile Val Gly His Val 
    130                 135                 140                 


Ala His Ser Lys Lys Ile Ala Asn Val Pro Asn Thr Glu Glu Asp Glu 
145                 150                 155                 160 


His Phe Cys Asp Phe Val Asp Ile Leu Thr Glu Tyr Lys Thr Lys Asn 
                165                 170                 175     


Ile Leu Ala Ser Pro Ile Met Asn Gly Lys Asp Val Val Ala Ile Ile 
            180                 185                 190         


Met Ala Val Asn Lys Val Asp Gly Ser His Phe Thr Lys Arg Asp Glu 
        195                 200                 205             


Glu Ile Leu Leu Lys Tyr Leu Asn Phe Ala Asn Leu Ile Met Lys Val 
    210                 215                 220                 


Tyr His Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Ile 
225                 230                 235                 240 


Leu Leu Trp Ser Gly Ser Lys Val Phe Glu Glu Leu Thr Asp Ile Glu 
                245                 250                 255     


Arg Gln Phe His Lys Ala Leu Tyr Thr Val Arg Ala Phe Leu Asn Cys 
            260                 265                 270         


Asp Arg Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Gln Lys Glu Phe 
        275                 280                 285             


Phe Asp Val Trp Pro Val Leu Met Gly Glu Val Pro Pro Tyr Ser Gly 
    290                 295                 300                 


Pro Arg Thr Pro Asp Gly Arg Glu Ile Asn Phe Tyr Lys Val Ile Asp 
305                 310                 315                 320 


Tyr Ile Leu His Gly Lys Glu Asp Ile Lys Val Ile Pro Asn Pro Pro 
                325                 330                 335     


Pro Asp His Trp Ala Leu Val Ser Gly Leu Pro Ala Tyr Val Ala Gln 
            340                 345                 350         


Asn Gly Leu Ile Cys Asn Ile Met Asn Ala Pro Ala Glu Asp Phe Phe 
        355                 360                 365             


Ala Phe Gln Lys Glu Pro Leu Asp Glu Ser Gly Trp Met Ile Lys Asn 
    370                 375                 380                 


Val Leu Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val 
385                 390                 395                 400 


Ala Thr Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Met Asp 
                405                 410                 415     


Glu Thr Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Leu 
            420                 425                 430         


Asn Pro Asp Thr Tyr Glu Ser Met Asn Lys Leu Glu Asn Arg Lys Asp 
        435                 440                 445             


Ile Phe Gln Asp Ile Val Lys Tyr His Val Lys Cys Asp Asn Glu Glu 
    450                 455                 460                 


Ile Gln Lys Ile Leu Lys Thr Arg Glu Val Tyr Gly Lys Glu Pro Trp 
465                 470                 475                 480 


Glu Cys Glu Glu Glu Glu Leu Ala Glu Ile Leu Gln Ala Glu Leu Pro 
                485                 490                 495     


Asp Ala Asp Lys Tyr Glu Ile Asn Lys Phe His Phe Ser Asp Leu Pro 
            500                 505                 510         


Leu Thr Glu Leu Glu Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu 
        515                 520                 525             


Leu Lys Val Val Asp Lys Phe His Ile Pro Gln Glu Ala Leu Val Arg 
    530                 535                 540                 


Phe Met Tyr Ser Leu Ser Lys Gly Tyr Arg Lys Ile Thr Tyr His Asn 
545                 550                 555                 560 


Trp Arg His Gly Phe Asn Val Gly Gln Thr Met Phe Ser Leu Leu Val 
                565                 570                 575     


Thr Gly Lys Leu Lys Arg Tyr Phe Thr Asp Leu Glu Ala Leu Ala Met 
            580                 585                 590         


Val Thr Ala Ala Phe Cys His Asp Ile Asp His Arg Gly Thr Asn Asn 
        595                 600                 605             


Leu Tyr Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser 
    610                 615                 620                 


Ser Ile Leu Glu Arg His His Leu Glu Phe Gly Lys Thr Leu Leu Arg 
625                 630                 635                 640 


Asp Glu Ser Leu Asn Ile Phe Gln Asn Leu Asn Arg Arg Gln His Glu 
                645                 650                 655     


His Ala Ile His Met Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala 
            660                 665                 670         


Leu Tyr Phe Lys Lys Arg Thr Met Phe Gln Lys Ile Val Asp Gln Ser 
        675                 680                 685             


Lys Thr Tyr Glu Ser Glu Gln Glu Trp Thr Gln Tyr Met Met Leu Glu 
    690                 695                 700                 


Gln Thr Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp 
705                 710                 715                 720 


Leu Ser Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Gln Val Ala Leu 
                725                 730                 735     


Leu Val Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val 
            740                 745                 750         


Leu Gln Gln Asn Pro Ile Pro Met Met Asp Arg Asn Lys Ala Asp Glu 
        755                 760                 765             


Leu Pro Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val 
    770                 775                 780                 


Tyr Lys Glu Phe Ser Arg Phe His Glu Glu Ile Thr Pro Met Leu Asp 
785                 790                 795                 800 


Gly Ile Thr Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr 
                805                 810                 815     


Asp Ala Lys Met Lys Val Gln Glu Glu Lys Lys Gln Lys Gln Gln Ser 
            820                 825                 830         


Ala Lys Ser Ala Ala Ala Gly Asn Gln Pro Gly Gly Asn Pro Ser Pro 
        835                 840                 845             


Gly Gly Ala Thr Thr Ser Lys Ser Cys Cys Ile Gln 
    850                 855                 860 


<210>  101
<211>  854
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Ser Leu Ser Glu Glu Gln Ala Arg Ser Phe Leu Asp Gln Asn Pro 
1               5                   10                  15      


Asp Phe Ala Arg Gln Tyr Phe Gly Lys Lys Leu Ser Pro Glu Asn Val 
            20                  25                  30          


Ala Ala Ala Cys Glu Asp Gly Cys Pro Pro Asp Cys Asp Ser Leu Arg 
        35                  40                  45              


Asp Leu Cys Gln Val Glu Glu Ser Thr Ala Leu Leu Glu Leu Val Gln 
    50                  55                  60                  


Asp Met Gln Glu Ser Ile Asn Met Glu Arg Val Val Phe Lys Val Leu 
65                  70                  75                  80  


Arg Arg Leu Cys Thr Leu Leu Gln Ala Asp Arg Cys Ser Leu Phe Met 
                85                  90                  95      


Tyr Arg Gln Arg Asn Gly Val Ala Glu Leu Ala Thr Arg Leu Phe Ser 
            100                 105                 110         


Val Gln Pro Asp Ser Val Leu Glu Asp Cys Leu Val Pro Pro Asp Ser 
        115                 120                 125             


Glu Ile Val Phe Pro Leu Asp Ile Gly Val Val Gly His Val Ala Gln 
    130                 135                 140                 


Thr Lys Lys Met Val Asn Val Glu Asp Val Ala Glu Cys Pro His Phe 
145                 150                 155                 160 


Ser Ser Phe Ala Asp Glu Leu Thr Asp Tyr Lys Thr Lys Asn Met Leu 
                165                 170                 175     


Ala Thr Pro Ile Met Asn Gly Lys Asp Val Val Ala Val Ile Met Ala 
            180                 185                 190         


Val Asn Lys Leu Asn Gly Pro Phe Phe Thr Ser Glu Asp Glu Asp Val 
        195                 200                 205             


Phe Leu Lys Tyr Leu Asn Phe Ala Thr Leu Tyr Leu Lys Ile Tyr His 
    210                 215                 220                 


Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Val Leu Leu 
225                 230                 235                 240 


Trp Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp Ile Glu Arg Gln 
                245                 250                 255     


Phe His Lys Ala Phe Tyr Thr Val Arg Ala Tyr Leu Asn Cys Glu Arg 
            260                 265                 270         


Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Glu Lys Glu Phe Phe Asp 
        275                 280                 285             


Val Trp Ser Val Leu Met Gly Glu Ser Gln Pro Tyr Ser Gly Pro Arg 
    290                 295                 300                 


Thr Pro Asp Gly Arg Glu Ile Val Phe Tyr Lys Val Ile Asp Tyr Ile 
305                 310                 315                 320 


Leu His Gly Lys Glu Glu Ile Lys Val Ile Pro Thr Pro Ser Ala Asp 
                325                 330                 335     


His Trp Ala Leu Ala Ser Gly Leu Pro Ser Tyr Val Ala Glu Ser Gly 
            340                 345                 350         


Phe Ile Cys Asn Ile Met Asn Ala Ser Ala Asp Glu Met Phe Lys Phe 
        355                 360                 365             


Gln Glu Gly Ala Leu Asp Asp Ser Gly Trp Leu Ile Lys Asn Val Leu 
    370                 375                 380                 


Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val Ala Thr 
385                 390                 395                 400 


Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Gln Asp Glu Val 
                405                 410                 415     


Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Met Asn Thr 
            420                 425                 430         


Asp Thr Tyr Asp Lys Met Asn Lys Leu Glu Asn Arg Lys Asp Ile Ala 
        435                 440                 445             


Gln Asp Met Val Leu Tyr His Val Lys Cys Asp Arg Asp Glu Ile Gln 
    450                 455                 460                 


Leu Ile Leu Pro Thr Arg Ala Arg Leu Gly Lys Glu Pro Ala Asp Cys 
465                 470                 475                 480 


Asp Glu Asp Glu Leu Gly Glu Ile Leu Lys Glu Glu Leu Pro Gly Pro 
                485                 490                 495     


Thr Thr Phe Asp Ile Tyr Glu Phe His Phe Ser Asp Leu Glu Cys Thr 
            500                 505                 510         


Glu Leu Asp Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu Leu Gly 
        515                 520                 525             


Val Val Arg Lys Phe Gln Ile Pro Gln Glu Val Leu Val Arg Phe Leu 
    530                 535                 540                 


Phe Ser Ile Ser Lys Gly Tyr Arg Arg Ile Thr Tyr His Asn Trp Arg 
545                 550                 555                 560 


His Gly Phe Asn Val Ala Gln Thr Met Phe Thr Leu Leu Met Thr Gly 
                565                 570                 575     


Lys Leu Lys Ser Tyr Tyr Thr Asp Leu Glu Ala Phe Ala Met Val Thr 
            580                 585                 590         


Ala Gly Leu Cys His Asp Ile Asp His Arg Gly Thr Asn Asn Leu Tyr 
        595                 600                 605             


Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser Ser Ile 
    610                 615                 620                 


Leu Glu Arg His His Leu Glu Phe Gly Lys Phe Leu Leu Ser Glu Glu 
625                 630                 635                 640 


Thr Leu Asn Ile Tyr Gln Asn Leu Asn Arg Arg Gln His Glu His Val 
                645                 650                 655     


Ile His Leu Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala Leu Tyr 
            660                 665                 670         


Phe Lys Lys Arg Ala Met Phe Gln Lys Ile Val Asp Glu Ser Lys Asn 
        675                 680                 685             


Tyr Gln Asp Lys Lys Ser Trp Val Glu Tyr Leu Ser Leu Glu Thr Thr 
    690                 695                 700                 


Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp Leu Ser 
705                 710                 715                 720 


Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Lys Val Ala Leu Leu Val 
                725                 730                 735     


Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val Leu Asp 
            740                 745                 750         


Gln Gln Pro Ile Pro Met Met Asp Arg Asn Lys Ala Ala Glu Leu Pro 
        755                 760                 765             


Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val Tyr Lys 
    770                 775                 780                 


Glu Phe Ser Arg Phe His Glu Glu Ile Leu Pro Met Phe Asp Arg Leu 
785                 790                 795                 800 


Gln Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr Glu Ala 
                805                 810                 815     


Lys Val Lys Ala Leu Glu Glu Lys Glu Glu Glu Glu Arg Val Ala Ala 
            820                 825                 830         


Lys Lys Val Gly Thr Glu Ile Cys Asn Gly Gly Pro Ala Pro Lys Ser 
        835                 840                 845             


Ser Thr Cys Cys Ile Leu 
    850                 


<210>  102
<211>  853
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Ser Leu Ser Glu Glu Gln Ala Arg Ser Phe Leu Asp Gln Asn Pro 
1               5                   10                  15      


Asp Phe Ala Arg Gln Tyr Phe Gly Lys Lys Leu Ser Pro Glu Asn Val 
            20                  25                  30          


Ala Ala Ala Cys Glu Asp Gly Cys Pro Pro Asp Cys Asp Ser Leu Arg 
        35                  40                  45              


Asp Leu Cys Gln Val Glu Glu Ser Thr Ala Leu Leu Glu Leu Val Gln 
    50                  55                  60                  


Asp Met Gln Glu Ser Ile Asn Met Glu Arg Val Val Phe Lys Val Leu 
65                  70                  75                  80  


Arg Arg Leu Cys Thr Leu Leu Gln Ala Asp Arg Cys Ser Leu Phe Met 
                85                  90                  95      


Tyr Arg Gln Arg Asn Gly Val Ala Glu Leu Ala Thr Arg Leu Phe Ser 
            100                 105                 110         


Val Gln Pro Asp Ser Val Leu Glu Asp Cys Leu Val Pro Pro Asp Ser 
        115                 120                 125             


Glu Ile Val Phe Pro Leu Asp Ile Gly Val Val Gly His Val Ala Gln 
    130                 135                 140                 


Thr Lys Lys Met Val Asn Val Glu Asp Val Ala Glu Cys Pro His Phe 
145                 150                 155                 160 


Ser Ser Phe Ala Asp Glu Leu Thr Asp Tyr Lys Thr Lys Asn Met Leu 
                165                 170                 175     


Ala Thr Pro Ile Met Asn Gly Lys Asp Val Val Ala Val Ile Met Ala 
            180                 185                 190         


Val Asn Lys Leu Asn Gly Pro Phe Phe Thr Ser Glu Asp Glu Asp Val 
        195                 200                 205             


Phe Leu Lys Tyr Leu Asn Phe Ala Thr Leu Tyr Leu Lys Ile Tyr His 
    210                 215                 220                 


Leu Ser Tyr Leu His Asn Cys Glu Thr Arg Arg Gly Gln Val Leu Leu 
225                 230                 235                 240 


Trp Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp Ile Glu Arg Gln 
                245                 250                 255     


Phe His Lys Ala Phe Tyr Thr Val Arg Ala Tyr Leu Asn Cys Glu Arg 
            260                 265                 270         


Tyr Ser Val Gly Leu Leu Asp Met Thr Lys Glu Lys Glu Phe Phe Asp 
        275                 280                 285             


Val Trp Ser Val Leu Met Gly Glu Ser Gln Pro Tyr Ser Gly Pro Arg 
    290                 295                 300                 


Thr Pro Asp Gly Arg Glu Ile Val Phe Tyr Lys Val Ile Asp Tyr Ile 
305                 310                 315                 320 


Leu His Gly Lys Glu Glu Ile Lys Val Ile Pro Thr Pro Ser Ala Asp 
                325                 330                 335     


His Trp Ala Leu Ala Ser Gly Leu Pro Ser Tyr Val Ala Glu Ser Gly 
            340                 345                 350         


Phe Ile Cys Asn Ile Met Asn Ala Ser Ala Asp Glu Met Phe Lys Phe 
        355                 360                 365             


Gln Glu Gly Ala Leu Asp Asp Ser Gly Trp Leu Ile Lys Asn Val Leu 
    370                 375                 380                 


Ser Met Pro Ile Val Asn Lys Lys Glu Glu Ile Val Gly Val Ala Thr 
385                 390                 395                 400 


Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu Gln Asp Glu Val 
                405                 410                 415     


Leu Met Glu Ser Leu Thr Gln Phe Leu Gly Trp Ser Val Met Asn Thr 
            420                 425                 430         


Asp Thr Tyr Asp Lys Met Asn Lys Leu Glu Asn Arg Lys Asp Ile Ala 
        435                 440                 445             


Gln Asp Met Val Leu Tyr His Val Lys Cys Asp Arg Asp Glu Ile Gln 
    450                 455                 460                 


Leu Ile Leu Pro Thr Arg Ala Arg Leu Gly Lys Glu Pro Ala Asp Cys 
465                 470                 475                 480 


Asp Glu Asp Glu Leu Gly Glu Ile Leu Lys Glu Glu Leu Pro Gly Pro 
                485                 490                 495     


Thr Thr Phe Asp Ile Tyr Glu Phe His Phe Ser Asp Leu Glu Cys Thr 
            500                 505                 510         


Glu Leu Asp Leu Val Lys Cys Gly Ile Gln Met Tyr Tyr Glu Leu Gly 
        515                 520                 525             


Val Val Arg Lys Phe Gln Ile Pro Gln Glu Val Leu Val Arg Phe Leu 
    530                 535                 540                 


Phe Ser Ile Ser Lys Gly Tyr Arg Arg Ile Thr Tyr His Asn Trp Arg 
545                 550                 555                 560 


His Gly Phe Asn Val Ala Gln Thr Met Phe Thr Leu Leu Met Thr Gly 
                565                 570                 575     


Lys Leu Lys Ser Tyr Tyr Thr Asp Leu Glu Ala Phe Ala Met Val Thr 
            580                 585                 590         


Ala Gly Leu Cys His Asp Ile Asp His Arg Gly Thr Asn Asn Leu Tyr 
        595                 600                 605             


Gln Met Lys Ser Gln Asn Pro Leu Ala Lys Leu His Gly Ser Ser Ile 
    610                 615                 620                 


Leu Glu Arg His His Leu Glu Phe Gly Lys Phe Leu Leu Ser Glu Glu 
625                 630                 635                 640 


Thr Leu Asn Ile Tyr Gln Asn Leu Asn Arg Arg Gln His Glu His Val 
                645                 650                 655     


Ile His Leu Met Asp Ile Ala Ile Ile Ala Thr Asp Leu Ala Leu Tyr 
            660                 665                 670         


Phe Lys Lys Arg Ala Met Phe Gln Lys Ile Val Asp Glu Ser Lys Asn 
        675                 680                 685             


Tyr Gln Asp Lys Lys Ser Trp Val Glu Tyr Leu Ser Leu Glu Thr Thr 
    690                 695                 700                 


Arg Lys Glu Ile Val Met Ala Met Met Met Thr Ala Cys Asp Leu Ser 
705                 710                 715                 720 


Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Lys Val Ala Leu Leu Val 
                725                 730                 735     


Ala Ala Glu Phe Trp Glu Gln Gly Asp Leu Glu Arg Thr Val Leu Asp 
            740                 745                 750         


Gln Gln Pro Ile Pro Met Met Asp Arg Asn Lys Ala Ala Glu Leu Pro 
        755                 760                 765             


Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys Thr Phe Val Tyr Lys 
    770                 775                 780                 


Glu Phe Ser Arg Phe His Glu Glu Ile Leu Pro Met Phe Asp Arg Leu 
785                 790                 795                 800 


Gln Asn Asn Arg Lys Glu Trp Lys Ala Leu Ala Asp Glu Tyr Glu Ala 
                805                 810                 815     


Lys Val Lys Ala Leu Glu Glu Lys Glu Glu Glu Glu Arg Val Ala Ala 
            820                 825                 830         


Lys Lys Gly Thr Glu Ile Cys Asn Gly Gly Pro Ala Pro Lys Ser Ser 
        835                 840                 845             


Thr Cys Cys Ile Leu 
    850             


<210>  103
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Thr Lys Glu Lys Glu Phe Phe Asp Val Trp Ser Val Leu Met Gly 
1               5                   10                  15      


Glu Ser Gln Pro Tyr Ser Gly Pro Arg Thr Pro Asp Gly Arg Glu Ile 
            20                  25                  30          


Val Phe Tyr Lys Val Ile Asp Tyr Ile Leu His Gly Lys Glu Glu Ile 
        35                  40                  45              


Lys Val Ile Pro Thr Pro Ser Ala Asp His Trp Ala Leu Ala Ser Gly 
    50                  55                  60                  


Leu Pro Ser Tyr Val Ala Glu Ser Gly Phe Ile Cys Asn Ile Met Asn 
65                  70                  75                  80  


Ala Ser Ala Asp Glu Met Phe Lys Phe Gln Glu Gly Ala Leu Asp Asp 
                85                  90                  95      


Ser Gly Trp Leu Ile Lys Asn Val Leu Ser Met Pro Ile Val Asn Lys 
            100                 105                 110         


Lys Glu Glu Ile Val Gly Val Ala Thr Phe Tyr Asn Arg Lys Asp Gly 
        115                 120                 125             


Lys Pro Phe Asp Glu Gln Asp Glu Val Leu Met Glu Ser Leu Thr Gln 
    130                 135                 140                 


Phe Leu Gly Trp Ser Val Met Asn Thr Asp Thr Tyr Asp Lys Met Asn 
145                 150                 155                 160 


Lys Leu Glu Asn Arg Lys Asp Ile Ala Gln Asp Met Val Leu Tyr His 
                165                 170                 175     


Val Lys Cys Asp Arg Asp Glu Ile Gln Leu Ile Leu Pro Thr Arg Ala 
            180                 185                 190         


Arg Leu Gly Lys Glu Pro Ala Asp Cys Asp Glu Asp Glu Leu Gly Glu 
        195                 200                 205             


Ile Leu Lys Glu Glu Leu Pro Gly Pro Thr Thr Phe Asp Ile Tyr Glu 
    210                 215                 220                 


Phe His Phe Ser Asp Leu Glu Cys Thr Glu Leu Asp Leu Val Lys Cys 
225                 230                 235                 240 


Gly Ile Gln Met Tyr Tyr Glu Leu Gly Val Val Arg Lys Phe Gln Ile 
                245                 250                 255     


Pro Gln Glu Val Leu Val Arg Phe Leu Phe Ser Ile Ser Lys Gly Tyr 
            260                 265                 270         


Arg Arg Ile Thr Tyr His Asn Trp Arg His Gly Phe Asn Val Ala Gln 
        275                 280                 285             


Thr Met Phe Thr Leu Leu Met Thr Gly Lys Leu Lys Ser Tyr Tyr Thr 
    290                 295                 300                 


Asp Leu Glu Ala Phe Ala Met Val Thr Ala Gly Leu Cys His Asp Ile 
305                 310                 315                 320 


Asp His Arg Gly Thr Asn Asn Leu Tyr Gln Met Lys Ser Gln Asn Pro 
                325                 330                 335     


Leu Ala Lys Leu His Gly Ser Ser Ile Leu Glu Arg His His Leu Glu 
            340                 345                 350         


Phe Gly Lys Phe Leu Leu Ser Glu Glu Thr Leu Asn Ile Tyr Gln Asn 
        355                 360                 365             


Leu Asn Arg Arg Gln His Glu His Val Ile His Leu Met Asp Ile Ala 
    370                 375                 380                 


Ile Ile Ala Thr Asp Leu Ala Leu Tyr Phe Lys Lys Arg Ala Met Phe 
385                 390                 395                 400 


Gln Lys Ile Val Asp Glu Ser Lys Asn Tyr Gln Asp Lys Lys Ser Trp 
                405                 410                 415     


Val Glu Tyr Leu Ser Leu Glu Thr Thr Arg Lys Glu Ile Val Met Ala 
            420                 425                 430         


Met Met Met Thr Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Glu 
        435                 440                 445             


Val Gln Ser Lys Val Ala Leu Leu Val Ala Ala Glu Phe Trp Glu Gln 
    450                 455                 460                 


Gly Asp Leu Glu Arg Thr Val Leu Asp Gln Gln Pro Ile Pro Met Met 
465                 470                 475                 480 


Asp Arg Asn Lys Ala Ala Glu Leu Pro Lys Leu Gln Val Gly Phe Ile 
                485                 490                 495     


Asp Phe Val Cys Thr Phe Val Tyr Lys Glu Phe Ser Arg Phe His Glu 
            500                 505                 510         


Glu Ile Leu Pro Met Phe Asp Arg Leu Gln Asn Asn Arg Lys Glu Trp 
        515                 520                 525             


Lys Ala Leu Ala Asp Glu Tyr Glu Ala Lys Val Lys Ala Leu Glu Glu 
    530                 535                 540                 


Lys Glu Glu Glu Glu Arg Val Ala Ala Lys Lys Val Gly Thr Glu Ile 
545                 550                 555                 560 


Cys Asn Gly Gly Pro Ala Pro Lys Ser Ser Thr Cys Cys Ile Leu 
                565                 570                 575 


<210>  104
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ala Lys Ile Asn Thr Gln Tyr Ser His Pro Ser Arg Thr His Leu 
1               5                   10                  15      


Lys Val Lys Thr Ser Asp Arg Asp Leu Asn Arg Ala Glu Asn Gly Leu 
            20                  25                  30          


Ser Arg Ala His Ser Ser Ser Glu Glu Thr Ser Ser Val Leu Gln Pro 
        35                  40                  45              


Gly Ile Ala Met Glu Thr Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser 
    50                  55                  60                  


Phe Thr Gly Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 
65                  70                  75                  80  


Arg Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 
                85                  90                  95      


Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser 
            100                 105                 110         


Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp 
        115                 120                 125             


Arg Gly Arg Ser Ala Trp Pro Leu Ala Lys Cys Asn Thr Asn Thr Ser 
    130                 135                 140                 


Asn Asn Thr Glu Glu Glu Lys Lys Thr Lys Lys Lys Asp Ala Ile Val 
145                 150                 155                 160 


Val Asp Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Thr Ala Ile Ala 
                165                 170                 175     


Leu Pro Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe 
            180                 185                 190         


Asp Glu Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr 
        195                 200                 205             


Ser Ala Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Thr 
    210                 215                 220                 


Gly Phe Leu Glu Gln Gly Leu Met Val Ser Asp Thr Asn Arg Leu Trp 
225                 230                 235                 240 


Gln His Tyr Lys Thr Thr Thr Gln Phe Lys Leu Asp Val Leu Ser Leu 
                245                 250                 255     


Val Pro Thr Asp Leu Ala Tyr Leu Lys Val Gly Thr Asn Tyr Pro Glu 
            260                 265                 270         


Val Arg Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe 
        275                 280                 285             


Asp Arg Thr Glu Thr Arg Thr Asn Tyr Pro Asn Met Phe Arg Ile Gly 
    290                 295                 300                 


Asn Leu Val Leu Tyr Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile 
305                 310                 315                 320 


Tyr Phe Ala Ile Ser Lys Phe Ile Gly Phe Gly Thr Asp Ser Trp Val 
                325                 330                 335     


Tyr Pro Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr 
            340                 345                 350         


Ile Tyr Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu 
        355                 360                 365             


Thr Pro Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp 
    370                 375                 380                 


Phe Leu Val Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Val Gly 
385                 390                 395                 400 


Ser Met Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys 
                405                 410                 415     


Ile Asp Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val Thr Lys Asp 
            420                 425                 430         


Leu Glu Thr Arg Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys 
        435                 440                 445             


Lys Thr Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu 
    450                 455                 460                 


Lys Ala Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val 
465                 470                 475                 480 


Arg Ile Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu 
                485                 490                 495     


Lys Leu Arg Pro Thr Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys 
            500                 505                 510         


Gly Asp Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala 
        515                 520                 525             


Val Val Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly 
    530                 535                 540                 


Ser Tyr Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser 
545                 550                 555                 560 


Gly Asn Arg Arg Thr Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu 
                565                 570                 575     


Phe Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro 
            580                 585                 590         


Glu Ala Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys 
        595                 600                 605             


Asp Asn Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys 
    610                 615                 620                 


Asp Leu Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Thr Leu 
625                 630                 635                 640 


Gln Thr Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Thr Gln Met 
                645                 650                 655     


Lys Met Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys Gly Gly 
            660                 665                 670         


Gly Asp Lys Pro Leu Ala Asp Gly Glu Val Pro Gly Asp Ala Thr Lys 
        675                 680                 685             


Thr Glu Asp Lys Gln Gln 
    690                 


<210>  105
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Lys Ile Asn Thr Gln Tyr Ser His Pro Ser Arg Thr His Leu 
1               5                   10                  15      


Lys Val Lys Thr Ser Asp Arg Asp Leu Asn Arg Ala Glu Asn Gly Leu 
            20                  25                  30          


Ser Arg Ala His Ser Ser Ser Glu Glu Thr Ser Ser Val Leu Gln Pro 
        35                  40                  45              


Gly Ile Ala Met Glu Thr Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser 
    50                  55                  60                  


Phe Thr Gly Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 
65                  70                  75                  80  


Arg Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 
                85                  90                  95      


Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser 
            100                 105                 110         


Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp 
        115                 120                 125             


Arg Gly Arg Arg Lys Lys Thr Lys Lys Lys Asp Ala Ile Val Val Asp 
    130                 135                 140                 


Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Thr Ala Ile Ala Leu Pro 
145                 150                 155                 160 


Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe Asp Glu 
                165                 170                 175     


Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr Ser Ala 
            180                 185                 190         


Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Thr Gly Phe 
        195                 200                 205             


Leu Glu Gln Gly Leu Met Val Ser Asp Thr Asn Arg Leu Trp Gln His 
    210                 215                 220                 


Tyr Lys Thr Thr Thr Gln Phe Lys Leu Asp Val Leu Ser Leu Val Pro 
225                 230                 235                 240 


Thr Asp Leu Ala Tyr Leu Lys Val Gly Thr Asn Tyr Pro Glu Val Arg 
                245                 250                 255     


Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe Asp Arg 
            260                 265                 270         


Thr Glu Thr Arg Thr Asn Tyr Pro Asn Met Phe Arg Ile Gly Asn Leu 
        275                 280                 285             


Val Leu Tyr Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile Tyr Phe 
    290                 295                 300                 


Ala Ile Ser Lys Phe Ile Gly Phe Gly Thr Asp Ser Trp Val Tyr Pro 
305                 310                 315                 320 


Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr Ile Tyr 
                325                 330                 335     


Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu Thr Pro 
            340                 345                 350         


Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp Phe Leu 
        355                 360                 365             


Val Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Val Gly Ser Met 
    370                 375                 380                 


Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys Ile Asp 
385                 390                 395                 400 


Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val Thr Lys Asp Leu Glu 
                405                 410                 415     


Thr Arg Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys Lys Thr 
            420                 425                 430         


Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu Lys Ala 
        435                 440                 445             


Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val Arg Ile 
    450                 455                 460                 


Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu Lys Leu 
465                 470                 475                 480 


Arg Pro Thr Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys Gly Asp 
                485                 490                 495     


Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala Val Val 
            500                 505                 510         


Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly Ser Tyr 
        515                 520                 525             


Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser Gly Asn 
    530                 535                 540                 


Arg Arg Thr Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu Phe Cys 
545                 550                 555                 560 


Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro Glu Ala 
                565                 570                 575     


Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys Asp Asn 
            580                 585                 590         


Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys Asp Leu 
        595                 600                 605             


Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Thr Leu Gln Thr 
    610                 615                 620                 


Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Thr Gln Met Lys Met 
625                 630                 635                 640 


Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys Gly Gly Gly Asp 
                645                 650                 655     


Lys Pro Leu Ala Asp Gly Glu Val Pro Gly Asp Ala Thr Lys Thr Glu 
            660                 665                 670         


Asp Lys Gln Gln 
        675     


<210>  106
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Phe Lys Ser Leu Thr Lys Val Asn Lys Val Lys Pro Ile Gly Glu 
1               5                   10                  15      


Asn Asn Glu Asn Glu Gln Ser Ser Arg Arg Asn Glu Glu Gly Ser His 
            20                  25                  30          


Pro Ser Asn Gln Ser Gln Gln Thr Thr Ala Gln Glu Glu Asn Lys Gly 
        35                  40                  45              


Glu Glu Lys Ser Leu Lys Thr Lys Ser Thr Pro Val Thr Ser Glu Glu 
    50                  55                  60                  


Pro His Thr Asn Ile Gln Asp Lys Leu Ser Lys Lys Asn Ser Ser Gly 
65                  70                  75                  80  


Asp Leu Thr Thr Asn Pro Asp Pro Gln Asn Ala Ala Glu Pro Thr Gly 
                85                  90                  95      


Thr Val Pro Glu Gln Lys Glu Met Asp Pro Gly Lys Glu Gly Pro Asn 
            100                 105                 110         


Ser Pro Gln Asn Lys Pro Pro Ala Ala Pro Val Ile Asn Glu Tyr Ala 
        115                 120                 125             


Asp Ala Gln Leu His Asn Leu Val Lys Arg Met Arg Gln Arg Thr Ala 
    130                 135                 140                 


Leu Tyr Lys Lys Lys Leu Val Glu Gly Asp Leu Ser Ser Pro Glu Ala 
145                 150                 155                 160 


Ser Pro Gln Thr Ala Lys Pro Thr Ala Val Pro Pro Val Lys Glu Ser 
                165                 170                 175     


Asp Asp Lys Pro Thr Glu His Tyr Tyr Arg Leu Leu Trp Phe Lys Val 
            180                 185                 190         


Lys Lys Met Pro Leu Thr Glu Tyr Leu Lys Arg Ile Lys Leu Pro Asn 
        195                 200                 205             


Ser Ile Asp Ser Tyr Thr Asp Arg Leu Tyr Leu Leu Trp Leu Leu Leu 
    210                 215                 220                 


Val Thr Leu Ala Tyr Asn Trp Asn Cys Cys Phe Ile Pro Leu Arg Leu 
225                 230                 235                 240 


Val Phe Pro Tyr Gln Thr Ala Asp Asn Ile His Tyr Trp Leu Ile Ala 
                245                 250                 255     


Asp Ile Ile Cys Asp Ile Ile Tyr Leu Tyr Asp Met Leu Phe Ile Gln 
            260                 265                 270         


Pro Arg Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Val Asp Ser Asn 
        275                 280                 285             


Glu Leu Arg Lys His Tyr Arg Thr Ser Thr Lys Phe Gln Leu Asp Val 
    290                 295                 300                 


Ala Ser Ile Ile Pro Phe Asp Ile Cys Tyr Leu Phe Phe Gly Phe Asn 
305                 310                 315                 320 


Pro Met Phe Arg Ala Asn Arg Met Leu Lys Tyr Thr Ser Phe Phe Glu 
                325                 330                 335     


Phe Asn His His Leu Glu Ser Ile Met Asp Lys Ala Tyr Ile Tyr Arg 
            340                 345                 350         


Val Ile Arg Thr Thr Gly Tyr Leu Leu Phe Ile Leu His Ile Asn Ala 
        355                 360                 365             


Cys Val Tyr Tyr Trp Ala Ser Asn Tyr Glu Gly Ile Gly Thr Thr Arg 
    370                 375                 380                 


Trp Val Tyr Asp Gly Glu Gly Asn Glu Tyr Leu Arg Cys Tyr Tyr Trp 
385                 390                 395                 400 


Ala Val Arg Thr Leu Ile Thr Ile Gly Gly Leu Pro Glu Pro Gln Thr 
                405                 410                 415     


Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Phe Phe Ser Gly Val Phe 
            420                 425                 430         


Val Phe Ser Ser Leu Ile Gly Gln Met Arg Asp Val Ile Gly Ala Ala 
        435                 440                 445             


Thr Ala Asn Gln Asn Tyr Phe Arg Ala Cys Met Asp Asp Thr Ile Ala 
    450                 455                 460                 


Tyr Met Asn Asn Tyr Ser Ile Pro Lys Leu Val Gln Lys Arg Val Arg 
465                 470                 475                 480 


Thr Trp Tyr Glu Tyr Thr Trp Asp Ser Gln Arg Met Leu Asp Glu Ser 
                485                 490                 495     


Asp Leu Leu Lys Thr Leu Pro Thr Thr Val Gln Leu Ala Leu Ala Ile 
            500                 505                 510         


Asp Val Asn Phe Ser Ile Ile Ser Lys Val Asp Leu Phe Lys Gly Cys 
        515                 520                 525             


Asp Thr Gln Met Ile Tyr Asp Met Leu Leu Arg Leu Lys Ser Val Leu 
    530                 535                 540                 


Tyr Leu Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys Glu 
545                 550                 555                 560 


Met Tyr Ile Ile Lys His Gly Glu Val Gln Val Leu Gly Gly Pro Asp 
                565                 570                 575     


Gly Thr Lys Val Leu Val Thr Leu Lys Ala Gly Ser Val Phe Gly Glu 
            580                 585                 590         


Ile Ser Leu Leu Ala Ala Gly Gly Gly Asn Arg Arg Thr Ala Asn Val 
        595                 600                 605             


Val Ala His Gly Phe Ala Asn Leu Leu Thr Leu Asp Lys Lys Thr Leu 
    610                 615                 620                 


Gln Glu Ile Leu Val His Tyr Pro Asp Ser Glu Arg Ile Leu Met Lys 
625                 630                 635                 640 


Lys Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Thr Ala Glu Ala Thr 
                645                 650                 655     


Pro Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro Lys Glu Glu Thr 
            660                 665                 670         


Pro Lys Leu Phe Lys Thr Leu Leu Gly Gly Thr Gly Lys Ala Ser Leu 
        675                 680                 685             


Ala Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala Gln Lys Lys Glu 
    690                 695                 700                 


Asn Ser Glu Gly Gly Glu Glu Glu Gly Lys Glu Asn Glu Asp Lys Gln 
705                 710                 715                 720 


Lys Glu Asn Glu Asp Lys Gln Lys Glu Asn Glu Asp Lys Gly Lys Glu 
                725                 730                 735     


Asn Glu Asp Lys Asp Lys Gly Arg Glu Pro Glu Glu Lys Pro Leu Asp 
            740                 745                 750         


Arg Pro Glu Cys Thr Ala Ser Pro Ile Ala Val Glu Glu Glu Pro His 
        755                 760                 765             


Ser Val Arg Arg Thr Val Leu Pro Arg Gly Thr Ser Arg Gln Ser Leu 
    770                 775                 780                 


Ile Ile Ser Met Ala Pro Ser Ala Glu Gly Gly Glu Glu Val Leu Thr 
785                 790                 795                 800 


Ile Glu Val Lys Glu Lys Ala Lys Gln 
                805                 


<210>  107
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Gly Ser Gly Ala Ser Ala Glu Asp Lys Glu Leu Ala Lys Arg Ser 
1               5                   10                  15      


Lys Glu Leu Glu Lys Lys Leu Gln Glu Asp Ala Asp Lys Glu Ala Lys 
            20                  25                  30          


Thr Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Gln Asp Gly Tyr Ser Pro Glu 
    50                  55                  60                  


Glu Cys Leu Glu Phe Lys Ala Ile Ile Tyr Gly Asn Val Leu Gln Ser 
65                  70                  75                  80  


Ile Leu Ala Ile Ile Arg Ala Met Thr Thr Leu Gly Ile Asp Tyr Ala 
                85                  90                  95      


Glu Pro Ser Cys Ala Asp Asp Gly Arg Gln Leu Asn Asn Leu Ala Asp 
            100                 105                 110         


Ser Ile Glu Glu Gly Thr Met Pro Pro Glu Leu Val Glu Val Ile Arg 
        115                 120                 125             


Arg Leu Trp Lys Asp Gly Gly Val Gln Ala Cys Phe Glu Arg Ala Ala 
    130                 135                 140                 


Glu Tyr Gln Leu Asn Asp Ser Ala Ser Tyr Tyr Leu Asn Gln Leu Glu 
145                 150                 155                 160 


Arg Ile Thr Asp Pro Glu Tyr Leu Pro Ser Glu Gln Asp Val Leu Arg 
                165                 170                 175     


Ser Arg Val Lys Thr Thr Gly Ile Ile Glu Thr Lys Phe Ser Val Lys 
            180                 185                 190         


Asp Leu Asn Phe Arg Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
        195                 200                 205             


Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Cys Ile Ile Phe Cys 
    210                 215                 220                 


Ala Ala Leu Ser Ala Tyr Asp Met Val Leu Val Glu Asp Asp Glu Val 
225                 230                 235                 240 


Asn Arg Met His Glu Ser Leu His Leu Phe Asn Ser Ile Cys Asn His 
                245                 250                 255     


Lys Phe Phe Ala Ala Thr Ser Ile Val Leu Phe Leu Asn Lys Lys Asp 
            260                 265                 270         


Leu Phe Glu Glu Lys Ile Lys Lys Val His Leu Ser Ile Cys Phe Pro 
        275                 280                 285             


Glu Tyr Asp Gly Asn Asn Ser Tyr Asp Asp Ala Gly Asn Tyr Ile Lys 
    290                 295                 300                 


Ser Gln Phe Leu Asp Leu Asn Met Arg Lys Asp Val Lys Glu Ile Tyr 
305                 310                 315                 320 


Ser His Met Thr Cys Ala Thr Asp Thr Gln Asn Val Lys Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Ile Ile Ile Lys Glu Asn Leu Lys Asp Cys Gly 
            340                 345                 350         


Leu Phe 
        


<210>  108
<211>  815
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys Glu Gly 
            580                 585                 590         


Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala 
        595                 600                 605             


Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu 
    610                 615                 620                 


Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Asp His Glu Phe Ser 
625                 630                 635                 640 


Lys Thr Glu Glu Leu Lys Leu Glu Asp Val Asp Glu Glu Ile Asn Ala 
                645                 650                 655     


Glu Asn Val Glu Ser Lys Lys Lys Thr Val Gly Asp Asp Glu Ser Val 
            660                 665                 670         


Pro Thr Gly Tyr His Ser Lys Thr Glu Gly Ala Glu Arg Thr Asn Asp 
        675                 680                 685             


Asp Ser Ser Ala Glu Thr Ile Glu Lys Lys Glu Lys Ala Asn Leu Glu 
    690                 695                 700                 


Glu Arg Ala Ile Cys Glu Tyr Asn Glu Asn Pro Lys Gly Tyr Met Leu 
705                 710                 715                 720 


Asp Asp Ala Asp Ser Ser Ser Leu Glu Ile Leu Glu Asn Ser Glu Thr 
                725                 730                 735     


Thr Pro Ser Lys Asp Met Lys Lys Thr Lys Lys Ile Phe Leu Phe Lys 
            740                 745                 750         


Arg Val Pro Ser Ile Asn Gln Lys Ile Val Lys Asn Asn Asn Glu Pro 
        755                 760                 765             


Leu Pro Glu Ile Lys Ser Ile Gly Asp Gln Ile Ile Leu Lys Ser Asp 
    770                 775                 780                 


Asn Lys Asp Ala Asp Gln Asn His Met Ser Gln Asn His Gln Asn Ile 
785                 790                 795                 800 


Pro Pro Thr Asn Thr Glu Arg Arg Ser Lys Ser Cys Thr Ile Leu 
                805                 810                 815 


<210>  109
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys Glu Gly 
            580                 585                 590         


Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala 
        595                 600                 605             


Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu 
    610                 615                 620                 


Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Tyr Ser Ala Ser His 
625                 630                 635                 640 


Ser Gln Ile Val Ser Val 
                645     


<210>  110
<211>  1152
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Glu Ile Pro Glu Glu Lys Glu Gly 
            580                 585                 590         


Ala Glu Asp Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala 
        595                 600                 605             


Asn Glu Glu Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu 
    610                 615                 620                 


Ile Leu Ser Asp Asp Leu Thr Asp Lys Ala Glu Val Ser Glu Gly Lys 
625                 630                 635                 640 


Ala Lys Ser Val Gly Glu Ala Glu Asp Gly Pro Glu Gly Arg Gly Asp 
                645                 650                 655     


Gly Thr Cys Glu Glu Gly Ser Ser Gly Ala Glu His Trp Gln Asp Glu 
            660                 665                 670         


Glu Arg Glu Lys Gly Glu Lys Asp Lys Gly Arg Gly Glu Met Glu Arg 
        675                 680                 685             


Pro Gly Glu Gly Glu Lys Glu Leu Ala Glu Lys Glu Glu Trp Lys Lys 
    690                 695                 700                 


Arg Asp Gly Glu Glu Gln Glu Gln Lys Glu Arg Glu Gln Gly His Gln 
705                 710                 715                 720 


Lys Glu Arg Asn Gln Glu Met Glu Glu Gly Gly Glu Glu Glu His Gly 
                725                 730                 735     


Glu Gly Glu Glu Glu Glu Gly Asp Arg Glu Glu Glu Glu Glu Lys Glu 
            740                 745                 750         


Gly Glu Gly Lys Glu Glu Gly Glu Gly Glu Glu Val Glu Gly Glu Arg 
        755                 760                 765             


Glu Lys Glu Glu Gly Glu Arg Lys Lys Glu Glu Arg Ala Gly Lys Glu 
    770                 775                 780                 


Glu Lys Gly Glu Glu Glu Gly Asp Gln Gly Glu Gly Glu Glu Glu Glu 
785                 790                 795                 800 


Thr Glu Gly Arg Gly Glu Glu Lys Glu Glu Gly Gly Glu Val Glu Gly 
                805                 810                 815     


Gly Glu Val Glu Glu Gly Lys Gly Glu Arg Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu 
        835                 840                 845             


Gly Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu Gly Glu Glu 
    850                 855                 860                 


Gly Glu Gly Glu Glu Glu Gly Glu Glu Gly Glu Gly Glu Gly Glu Glu 
865                 870                 875                 880 


Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu 
                885                 890                 895     


Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly 
            900                 905                 910         


Glu Glu Glu Glu Gly Glu Gly Lys Gly Glu Glu Glu Gly Glu Glu Gly 
        915                 920                 925             


Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Asp Gly 
    930                 935                 940                 


Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Trp Glu Gly Glu Glu Glu 
945                 950                 955                 960 


Glu Gly Glu Gly Glu Gly Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu 
                965                 970                 975     


Gly Glu Gly Glu Gly Glu Glu Glu Glu Gly Glu Gly Glu Gly Glu Glu 
            980                 985                 990         


Glu Glu Gly Glu Glu Glu Gly Glu  Glu Glu Gly Glu Gly  Glu Glu Glu 
        995                 1000                 1005             


Gly Glu  Gly Glu Gly Glu Glu  Glu Glu Glu Gly Glu  Val Glu Gly 
    1010                 1015                 1020             


Glu Val  Glu Gly Glu Glu Gly  Glu Gly Glu Gly Glu  Glu Glu Glu 
    1025                 1030                 1035             


Gly Glu  Glu Glu Gly Glu Glu  Arg Glu Lys Glu Gly  Glu Gly Glu 
    1040                 1045                 1050             


Glu Asn  Arg Arg Asn Arg Glu  Glu Glu Glu Glu Glu  Glu Gly Lys 
    1055                 1060                 1065             


Tyr Gln  Glu Thr Gly Glu Glu  Glu Asn Glu Arg Gln  Asp Gly Glu 
    1070                 1075                 1080             


Glu Tyr  Lys Lys Val Ser Lys  Ile Lys Gly Ser Val  Lys Tyr Gly 
    1085                 1090                 1095             


Lys His  Lys Thr Tyr Gln Lys  Lys Ser Val Thr Asn  Thr Gln Gly 
    1100                 1105                 1110             


Asn Gly  Lys Glu Gln Arg Ser  Lys Met Pro Val Gln  Ser Lys Arg 
    1115                 1120                 1125             


Leu Leu  Lys Asn Gly Pro Ser  Gly Ser Lys Lys Phe  Trp Asn Asn 
    1130                 1135                 1140             


Val Leu  Pro His Tyr Leu Glu  Leu Lys 
    1145                 1150         


<210>  111
<211>  1020
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Arg Glu Pro Glu Glu Leu Met Pro Asp Ser Gly Ala Val Phe Thr 
1               5                   10                  15      


Phe Gly Lys Ser Lys Phe Ala Glu Asn Asn Pro Gly Lys Phe Trp Phe 
            20                  25                  30          


Lys Asn Asp Val Pro Val His Leu Ser Cys Gly Asp Glu His Ser Ala 
        35                  40                  45              


Val Val Thr Gly Asn Asn Lys Leu Tyr Met Phe Gly Ser Asn Asn Trp 
    50                  55                  60                  


Gly Gln Leu Gly Leu Gly Ser Lys Ser Ala Ile Ser Lys Pro Thr Cys 
65                  70                  75                  80  


Val Lys Ala Leu Lys Pro Glu Lys Val Lys Leu Ala Ala Cys Gly Arg 
                85                  90                  95      


Asn His Thr Leu Val Ser Thr Glu Gly Gly Asn Val Tyr Ala Thr Gly 
            100                 105                 110         


Gly Asn Asn Glu Gly Gln Leu Gly Leu Gly Asp Thr Glu Glu Arg Asn 
        115                 120                 125             


Thr Phe His Val Ile Ser Phe Phe Thr Ser Glu His Lys Ile Lys Gln 
    130                 135                 140                 


Leu Ser Ala Gly Ser Asn Thr Ser Ala Ala Leu Thr Glu Asp Gly Arg 
145                 150                 155                 160 


Leu Phe Met Trp Gly Asp Asn Ser Glu Gly Gln Ile Gly Leu Lys Asn 
                165                 170                 175     


Val Ser Asn Val Cys Val Pro Gln Gln Val Thr Ile Gly Lys Pro Val 
            180                 185                 190         


Ser Trp Ile Ser Cys Gly Tyr Tyr His Ser Ala Phe Val Thr Thr Asp 
        195                 200                 205             


Gly Glu Leu Tyr Val Phe Gly Glu Pro Glu Asn Gly Lys Leu Gly Leu 
    210                 215                 220                 


Pro Asn Gln Leu Leu Gly Asn His Arg Thr Pro Gln Leu Val Ser Glu 
225                 230                 235                 240 


Ile Pro Glu Lys Val Ile Gln Val Ala Cys Gly Gly Glu His Thr Val 
                245                 250                 255     


Val Leu Thr Glu Asn Ala Val Tyr Thr Phe Gly Leu Gly Gln Phe Gly 
            260                 265                 270         


Gln Leu Gly Leu Gly Thr Phe Leu Phe Glu Thr Ser Glu Pro Lys Val 
        275                 280                 285             


Ile Glu Asn Ile Arg Asp Gln Thr Ile Ser Tyr Ile Ser Cys Gly Glu 
    290                 295                 300                 


Asn His Thr Ala Leu Ile Thr Asp Ile Gly Leu Met Tyr Thr Phe Gly 
305                 310                 315                 320 


Asp Gly Arg His Gly Lys Leu Gly Leu Gly Leu Glu Asn Phe Thr Asn 
                325                 330                 335     


His Phe Ile Pro Thr Leu Cys Ser Asn Phe Leu Arg Phe Ile Val Lys 
            340                 345                 350         


Leu Val Ala Cys Gly Gly Cys His Met Val Val Phe Ala Ala Pro His 
        355                 360                 365             


Arg Gly Val Ala Lys Glu Ile Glu Phe Asp Glu Ile Asn Asp Thr Cys 
    370                 375                 380                 


Leu Ser Val Ala Thr Phe Leu Pro Tyr Ser Ser Leu Thr Ser Gly Asn 
385                 390                 395                 400 


Val Leu Gln Arg Thr Leu Ser Ala Arg Met Arg Arg Arg Glu Arg Glu 
                405                 410                 415     


Arg Ser Pro Asp Ser Phe Ser Met Arg Arg Thr Leu Pro Pro Ile Glu 
            420                 425                 430         


Gly Thr Leu Gly Leu Ser Ala Cys Phe Leu Pro Asn Ser Val Phe Pro 
        435                 440                 445             


Arg Cys Ser Glu Arg Asn Leu Gln Glu Ser Val Leu Ser Glu Gln Asp 
    450                 455                 460                 


Leu Met Gln Pro Glu Glu Pro Asp Tyr Leu Leu Asp Glu Met Thr Lys 
465                 470                 475                 480 


Glu Ala Glu Ile Asp Asn Ser Ser Thr Val Glu Ser Leu Gly Glu Thr 
                485                 490                 495     


Thr Asp Ile Leu Asn Met Thr His Ile Met Ser Leu Asn Ser Asn Glu 
            500                 505                 510         


Lys Ser Leu Lys Leu Ser Pro Val Gln Lys Gln Lys Lys Gln Gln Thr 
        515                 520                 525             


Ile Gly Glu Leu Thr Gln Asp Thr Ala Leu Thr Glu Asn Asp Asp Ser 
    530                 535                 540                 


Asp Glu Tyr Glu Glu Met Ser Glu Met Lys Glu Gly Lys Ala Cys Lys 
545                 550                 555                 560 


Gln His Val Ser Gln Gly Ile Phe Met Thr Gln Pro Ala Thr Thr Ile 
                565                 570                 575     


Glu Ala Phe Ser Asp Glu Glu Val Gly Asn Asp Thr Gly Gln Val Gly 
            580                 585                 590         


Pro Gln Ala Asp Thr Asp Gly Glu Gly Leu Gln Lys Glu Val Tyr Arg 
        595                 600                 605             


His Glu Asn Asn Asn Gly Val Asp Gln Leu Asp Ala Lys Glu Ile Glu 
    610                 615                 620                 


Lys Glu Ser Asp Gly Gly His Ser Gln Lys Glu Ser Glu Ala Glu Glu 
625                 630                 635                 640 


Ile Asp Ser Glu Lys Glu Thr Lys Leu Ala Glu Ile Ala Gly Met Lys 
                645                 650                 655     


Asp Leu Arg Glu Arg Glu Lys Ser Thr Lys Lys Met Ser Pro Phe Phe 
            660                 665                 670         


Gly Asn Leu Pro Asp Arg Gly Met Asn Thr Glu Ser Glu Glu Asn Lys 
        675                 680                 685             


Asp Phe Val Lys Lys Arg Glu Ser Cys Lys Gln Asp Val Ile Phe Asp 
    690                 695                 700                 


Ser Glu Arg Glu Ser Val Glu Lys Pro Asp Ser Tyr Met Glu Gly Ala 
705                 710                 715                 720 


Ser Glu Ser Gln Gln Gly Ile Ala Asp Gly Phe Gln Gln Pro Glu Ala 
                725                 730                 735     


Ile Glu Phe Ser Ser Gly Glu Lys Glu Asp Asp Glu Val Glu Thr Asp 
            740                 745                 750         


Gln Asn Ile Arg Tyr Gly Arg Lys Leu Ile Glu Gln Gly Asn Glu Lys 
        755                 760                 765             


Glu Thr Lys Pro Ile Ile Ser Lys Ser Met Ala Lys Tyr Asp Phe Lys 
    770                 775                 780                 


Cys Asp Arg Leu Ser Glu Ile Pro Glu Glu Lys Glu Gly Ala Glu Asp 
785                 790                 795                 800 


Ser Lys Gly Asn Gly Ile Glu Glu Gln Glu Val Glu Ala Asn Glu Glu 
                805                 810                 815     


Asn Val Lys Val His Gly Gly Arg Lys Glu Lys Thr Glu Ile Leu Ser 
            820                 825                 830         


Asp Asp Leu Thr Asp Lys Ala Glu Asp His Glu Phe Ser Lys Thr Glu 
        835                 840                 845             


Glu Leu Lys Leu Glu Asp Val Asp Glu Glu Ile Asn Ala Glu Asn Val 
    850                 855                 860                 


Glu Ser Lys Lys Lys Thr Val Gly Asp Asp Glu Ser Val Pro Thr Gly 
865                 870                 875                 880 


Tyr His Ser Lys Thr Glu Gly Ala Glu Arg Thr Asn Asp Asp Ser Ser 
                885                 890                 895     


Ala Glu Thr Ile Glu Lys Lys Glu Lys Ala Asn Leu Glu Glu Arg Ala 
            900                 905                 910         


Ile Cys Glu Tyr Asn Glu Asn Pro Lys Gly Tyr Met Leu Asp Asp Ala 
        915                 920                 925             


Asp Ser Ser Ser Leu Glu Ile Leu Glu Asn Ser Glu Thr Thr Pro Ser 
    930                 935                 940                 


Lys Asp Met Lys Lys Thr Lys Lys Ile Phe Leu Phe Lys Arg Val Pro 
945                 950                 955                 960 


Ser Ile Asn Gln Lys Ile Val Lys Asn Asn Asn Glu Pro Leu Pro Glu 
                965                 970                 975     


Ile Lys Ser Ile Gly Asp Gln Ile Ile Leu Lys Ser Asp Asn Lys Asp 
            980                 985                 990         


Ala Asp Gln Asn His Met Ser Gln  Asn His Gln Asn Ile  Pro Pro Thr 
        995                 1000                 1005             


Asn Thr  Glu Arg Arg Ser Lys  Ser Cys Thr Ile Leu  
    1010                 1015                 1020 


<210>  112
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  112

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  113
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  113

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  114
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  114

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  115
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  115

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  116
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  116

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Ala 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Ala Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Ala  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  117
<211>  1367
<212>  PRT
<213>  Streptococcus pyogenes

<400>  117

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Ala 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Ala Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Ala Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Ala Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  118
<211>  1053
<212>  PRT
<213>  Staphylococcus aureus

<400>  118

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  119
<211>  1300
<212>  PRT
<213>  Francisella tularensis

<400>  119

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  120
<211>  1306
<212>  PRT
<213>  Acidaminococcus sp.

<400>  120

Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr Leu 
1               5                   10                  15      


Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln Glu 
            20                  25                  30          


Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys Glu 
        35                  40                  45              


Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln Cys 
    50                  55                  60                  


Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile Asp 
65                  70                  75                  80  


Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile Glu 
                85                  90                  95      


Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly Arg 
            100                 105                 110         


Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile Tyr 
        115                 120                 125             


Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys Gln 
    130                 135                 140                 


Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg Ser 
145                 150                 155                 160 


Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg Lys 
                165                 170                 175     


Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg Ile 
            180                 185                 190         


Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe Thr 
        195                 200                 205             


Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn Val 
    210                 215                 220                 


Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val Phe 
225                 230                 235                 240 


Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp Leu 
                245                 250                 255     


Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu Lys 
            260                 265                 270         


Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn Asp 
        275                 280                 285             


Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro Leu 
    290                 295                 300                 


Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu Glu 
305                 310                 315                 320 


Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr Lys 
                325                 330                 335     


Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu Phe 
            340                 345                 350         


Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His Lys 
        355                 360                 365             


Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr Leu 
    370                 375                 380                 


Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys Ile 
385                 390                 395                 400 


Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu Asp 
                405                 410                 415     


Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser Glu 
            420                 425                 430         


Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala Ala 
        435                 440                 445             


Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys Glu 
    450                 455                 460                 


Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu Leu 
465                 470                 475                 480 


Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe Ser 
                485                 490                 495     


Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser Phe 
            500                 505                 510         


Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val Glu 
        515                 520                 525             


Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp Asp 
    530                 535                 540                 


Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn Gly 
545                 550                 555                 560 


Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys Ala 
                565                 570                 575     


Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys Met 
            580                 585                 590         


Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys Ser 
        595                 600                 605             


Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr Pro 
    610                 615                 620                 


Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys Glu 
625                 630                 635                 640 


Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln Thr 
                645                 650                 655     


Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala Leu 
            660                 665                 670         


Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr Lys 
        675                 680                 685             


Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr Lys 
    690                 695                 700                 


Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His Ile 
705                 710                 715                 720 


Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu Thr 
                725                 730                 735     


Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys Gly 
            740                 745                 750         


His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu Phe 
        755                 760                 765             


Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln Ala 
    770                 775                 780                 


Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His Arg 
785                 790                 795                 800 


Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr Pro 
                805                 810                 815     


Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His Arg 
            820                 825                 830         


Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn Val 
        835                 840                 845             


Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe Thr 
    850                 855                 860                 


Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln Ala 
865                 870                 875                 880 


Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu Lys 
                885                 890                 895     


Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn 
            900                 905                 910         


Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu Gln 
        915                 920                 925             


Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu Asp 
    930                 935                 940                 


Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val Val 
945                 950                 955                 960 


Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile His 
                965                 970                 975     


Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu Glu 
            980                 985                 990         


Asn Leu Asn Phe Gly Phe Lys Ser  Lys Arg Thr Gly Ile  Ala Glu Lys 
        995                 1000                 1005             


Ala Val  Tyr Gln Gln Phe Glu  Lys Met Leu Ile Asp  Lys Leu Asn 
    1010                 1015                 1020             


Cys Leu  Val Leu Lys Asp Tyr  Pro Ala Glu Lys Val  Gly Gly Val 
    1025                 1030                 1035             


Leu Asn  Pro Tyr Gln Leu Thr  Asp Gln Phe Thr Ser  Phe Ala Lys 
    1040                 1045                 1050             


Met Gly  Thr Gln Ser Gly Phe  Leu Phe Tyr Val Pro  Ala Pro Tyr 
    1055                 1060                 1065             


Thr Ser  Lys Ile Asp Pro Leu  Thr Gly Phe Val Asp  Pro Phe Val 
    1070                 1075                 1080             


Trp Lys  Thr Ile Lys Asn His  Glu Ser Arg Lys His  Phe Leu Glu 
    1085                 1090                 1095             


Gly Phe  Asp Phe Leu His Tyr  Asp Val Lys Thr Gly  Asp Phe Ile 
    1100                 1105                 1110             


Leu His  Phe Lys Met Asn Arg  Asn Leu Ser Phe Gln  Arg Gly Leu 
    1115                 1120                 1125             


Pro Gly  Phe Met Pro Ala Trp  Asp Ile Val Phe Glu  Lys Asn Glu 
    1130                 1135                 1140             


Thr Gln  Phe Asp Ala Lys Gly  Thr Pro Phe Ile Ala  Gly Lys Arg 
    1145                 1150                 1155             


Ile Val  Pro Val Ile Glu Asn  His Arg Phe Thr Gly  Arg Tyr Arg 
    1160                 1165                 1170             


Asp Leu  Tyr Pro Ala Asn Glu  Leu Ile Ala Leu Leu  Glu Glu Lys 
    1175                 1180                 1185             


Gly Ile  Val Phe Arg Asp Gly  Ser Asn Ile Leu Pro  Lys Leu Leu 
    1190                 1195                 1200             


Glu Asn  Asp Asp Ser His Ala  Ile Asp Thr Met Val  Ala Leu Ile 
    1205                 1210                 1215             


Arg Ser  Val Leu Gln Met Arg  Asn Ser Asn Ala Ala  Thr Gly Glu 
    1220                 1225                 1230             


Asp Tyr  Ile Asn Ser Pro Val  Arg Asp Leu Asn Gly  Val Cys Phe 
    1235                 1240                 1245             


Asp Ser  Arg Phe Gln Asn Pro  Glu Trp Pro Met Asp  Ala Asp Ala 
    1250                 1255                 1260             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Gln Leu  Leu Leu Asn 
    1265                 1270                 1275             


His Leu  Lys Glu Ser Lys Asp  Leu Lys Leu Gln Asn  Gly Ile Ser 
    1280                 1285                 1290             


Asn Gln  Asp Trp Leu Ala Tyr  Ile Gln Glu Leu Arg  Asn 
    1295                 1300                 1305     


<210>  121
<211>  1306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  121

Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr Leu 
1               5                   10                  15      


Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln Glu 
            20                  25                  30          


Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys Glu 
        35                  40                  45              


Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln Cys 
    50                  55                  60                  


Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile Asp 
65                  70                  75                  80  


Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile Glu 
                85                  90                  95      


Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly Arg 
            100                 105                 110         


Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile Tyr 
        115                 120                 125             


Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys Gln 
    130                 135                 140                 


Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg Ser 
145                 150                 155                 160 


Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg Lys 
                165                 170                 175     


Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg Ile 
            180                 185                 190         


Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe Thr 
        195                 200                 205             


Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn Val 
    210                 215                 220                 


Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val Phe 
225                 230                 235                 240 


Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp Leu 
                245                 250                 255     


Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu Lys 
            260                 265                 270         


Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn Asp 
        275                 280                 285             


Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro Leu 
    290                 295                 300                 


Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu Glu 
305                 310                 315                 320 


Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr Lys 
                325                 330                 335     


Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu Phe 
            340                 345                 350         


Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His Lys 
        355                 360                 365             


Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr Leu 
    370                 375                 380                 


Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys Ile 
385                 390                 395                 400 


Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu Asp 
                405                 410                 415     


Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser Glu 
            420                 425                 430         


Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala Ala 
        435                 440                 445             


Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys Glu 
    450                 455                 460                 


Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu Leu 
465                 470                 475                 480 


Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe Ser 
                485                 490                 495     


Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser Phe 
            500                 505                 510         


Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val Glu 
        515                 520                 525             


Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp Asp 
    530                 535                 540                 


Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn Gly 
545                 550                 555                 560 


Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys Ala 
                565                 570                 575     


Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys Met 
            580                 585                 590         


Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys Ser 
        595                 600                 605             


Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr Pro 
    610                 615                 620                 


Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys Glu 
625                 630                 635                 640 


Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln Thr 
                645                 650                 655     


Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala Leu 
            660                 665                 670         


Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr Lys 
        675                 680                 685             


Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr Lys 
    690                 695                 700                 


Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His Ile 
705                 710                 715                 720 


Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu Thr 
                725                 730                 735     


Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys Gly 
            740                 745                 750         


His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu Phe 
        755                 760                 765             


Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln Ala 
    770                 775                 780                 


Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His Arg 
785                 790                 795                 800 


Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr Pro 
                805                 810                 815     


Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His Arg 
            820                 825                 830         


Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn Val 
        835                 840                 845             


Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe Thr 
    850                 855                 860                 


Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln Ala 
865                 870                 875                 880 


Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu Lys 
                885                 890                 895     


Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn 
            900                 905                 910         


Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu Gln 
        915                 920                 925             


Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu Asp 
    930                 935                 940                 


Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val Val 
945                 950                 955                 960 


Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile His 
                965                 970                 975     


Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu Glu 
            980                 985                 990         


Asn Leu Asn Phe Gly Phe Lys Ser  Lys Arg Thr Gly Ile  Ala Glu Lys 
        995                 1000                 1005             


Ala Val  Tyr Gln Gln Phe Glu  Lys Met Leu Ile Asp  Lys Leu Asn 
    1010                 1015                 1020             


Cys Leu  Val Leu Lys Asp Tyr  Pro Ala Glu Lys Val  Gly Gly Val 
    1025                 1030                 1035             


Leu Asn  Pro Tyr Gln Leu Thr  Asp Gln Phe Thr Ser  Phe Ala Lys 
    1040                 1045                 1050             


Met Gly  Thr Gln Ser Gly Phe  Leu Phe Tyr Val Pro  Ala Pro Tyr 
    1055                 1060                 1065             


Thr Ser  Lys Ile Asp Pro Leu  Thr Gly Phe Val Asp  Pro Phe Val 
    1070                 1075                 1080             


Trp Lys  Thr Ile Lys Asn His  Glu Ser Arg Lys His  Phe Leu Glu 
    1085                 1090                 1095             


Gly Phe  Asp Phe Leu His Tyr  Asp Val Lys Thr Gly  Asp Phe Ile 
    1100                 1105                 1110             


Leu His  Phe Lys Met Asn Arg  Asn Leu Ser Phe Gln  Arg Gly Leu 
    1115                 1120                 1125             


Pro Gly  Phe Met Pro Ala Trp  Asp Ile Val Phe Glu  Lys Asn Glu 
    1130                 1135                 1140             


Thr Gln  Phe Asp Ala Lys Gly  Thr Pro Phe Ile Ala  Gly Lys Arg 
    1145                 1150                 1155             


Ile Val  Pro Val Ile Glu Asn  His Arg Phe Thr Gly  Arg Tyr Arg 
    1160                 1165                 1170             


Asp Leu  Tyr Pro Ala Asn Glu  Leu Ile Ala Leu Leu  Glu Glu Lys 
    1175                 1180                 1185             


Gly Ile  Val Phe Arg Asp Gly  Ser Asn Ile Leu Pro  Lys Leu Leu 
    1190                 1195                 1200             


Glu Asn  Asp Asp Ser His Ala  Ile Asp Thr Met Val  Ala Leu Ile 
    1205                 1210                 1215             


Arg Ser  Val Leu Gln Met Ala  Asn Ser Asn Ala Ala  Thr Gly Glu 
    1220                 1225                 1230             


Asp Tyr  Ile Asn Ser Pro Val  Arg Asp Leu Asn Gly  Val Cys Phe 
    1235                 1240                 1245             


Asp Ser  Arg Phe Gln Asn Pro  Glu Trp Pro Met Asp  Ala Asp Ala 
    1250                 1255                 1260             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Gln Leu  Leu Leu Asn 
    1265                 1270                 1275             


His Leu  Lys Glu Ser Lys Asp  Leu Lys Leu Gln Asn  Gly Ile Ser 
    1280                 1285                 1290             


Asn Gln  Asp Trp Leu Ala Tyr  Ile Gln Glu Leu Arg  Asn 
    1295                 1300                 1305     


<210>  122
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Gly Ser Leu Leu Ala Leu Leu Ala Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Glu Gly Pro Ala Lys Lys Val Leu Thr Leu Glu Gly Asp Leu 
            20                  25                  30          


Val Leu Gly Gly Leu Phe Pro Val His Gln Lys Gly Gly Pro Ala Glu 
        35                  40                  45              


Asp Cys Gly Pro Val Asn Glu His Arg Gly Ile Gln Arg Leu Glu Ala 
    50                  55                  60                  


Met Leu Phe Ala Leu Asp Arg Ile Asn Arg Asp Pro His Leu Leu Pro 
65                  70                  75                  80  


Gly Val Arg Leu Gly Ala His Ile Leu Asp Ser Cys Ser Lys Asp Thr 
                85                  90                  95      


His Ala Leu Glu Gln Ala Leu Asp Phe Val Arg Ala Ser Leu Ser Arg 
            100                 105                 110         


Gly Ala Asp Gly Ser Arg His Ile Cys Pro Asp Gly Ser Tyr Ala Thr 
        115                 120                 125             


His Gly Asp Ala Pro Thr Ala Ile Thr Gly Val Ile Gly Gly Ser Tyr 
    130                 135                 140                 


Ser Asp Val Ser Ile Gln Val Ala Asn Leu Leu Arg Leu Phe Gln Ile 
145                 150                 155                 160 


Pro Gln Ile Ser Tyr Ala Ser Thr Ser Ala Lys Leu Ser Asp Lys Ser 
                165                 170                 175     


Arg Tyr Asp Tyr Phe Ala Arg Thr Val Pro Pro Asp Phe Phe Gln Ala 
            180                 185                 190         


Lys Ala Met Ala Glu Ile Leu Arg Phe Phe Asn Trp Thr Tyr Val Ser 
        195                 200                 205             


Thr Val Ala Ser Glu Gly Asp Tyr Gly Glu Thr Gly Ile Glu Ala Phe 
    210                 215                 220                 


Glu Leu Glu Ala Arg Ala Arg Asn Ile Cys Val Ala Thr Ser Glu Lys 
225                 230                 235                 240 


Val Gly Arg Ala Met Ser Arg Ala Ala Phe Glu Gly Val Val Arg Ala 
                245                 250                 255     


Leu Leu Gln Lys Pro Ser Ala Arg Val Ala Val Leu Phe Thr Arg Ser 
            260                 265                 270         


Glu Asp Ala Arg Glu Leu Leu Ala Ala Ser Gln Arg Leu Asn Ala Ser 
        275                 280                 285             


Phe Thr Trp Val Ala Ser Asp Gly Trp Gly Ala Leu Glu Ser Val Val 
    290                 295                 300                 


Ala Gly Ser Glu Gly Ala Ala Glu Gly Ala Ile Thr Ile Glu Leu Ala 
305                 310                 315                 320 


Ser Tyr Pro Ile Ser Asp Phe Ala Ser Tyr Phe Gln Ser Leu Asp Pro 
                325                 330                 335     


Trp Asn Asn Ser Arg Asn Pro Trp Phe Arg Glu Phe Trp Glu Gln Arg 
            340                 345                 350         


Phe Arg Cys Ser Phe Arg Gln Arg Asp Cys Ala Ala His Ser Leu Arg 
        355                 360                 365             


Ala Val Pro Phe Glu Gln Glu Ser Lys Ile Met Phe Val Val Asn Ala 
    370                 375                 380                 


Val Tyr Ala Met Ala His Ala Leu His Asn Met His Arg Ala Leu Cys 
385                 390                 395                 400 


Pro Asn Thr Thr Arg Leu Cys Asp Ala Met Arg Pro Val Asn Gly Arg 
                405                 410                 415     


Arg Leu Tyr Lys Asp Phe Val Leu Asn Val Lys Phe Asp Ala Pro Phe 
            420                 425                 430         


Arg Pro Ala Asp Thr His Asn Glu Val Arg Phe Asp Arg Phe Gly Asp 
        435                 440                 445             


Gly Ile Gly Arg Tyr Asn Ile Phe Thr Tyr Leu Arg Ala Gly Ser Gly 
    450                 455                 460                 


Arg Tyr Arg Tyr Gln Lys Val Gly Tyr Trp Ala Glu Gly Leu Thr Leu 
465                 470                 475                 480 


Asp Thr Ser Leu Ile Pro Trp Ala Ser Pro Ser Ala Gly Pro Leu Pro 
                485                 490                 495     


Ala Ser Arg Cys Ser Glu Pro Cys Leu Gln Asn Glu Val Lys Ser Val 
            500                 505                 510         


Gln Pro Gly Glu Val Cys Cys Trp Leu Cys Ile Pro Cys Gln Pro Tyr 
        515                 520                 525             


Glu Tyr Arg Leu Asp Glu Phe Thr Cys Ala Asp Cys Gly Leu Gly Tyr 
    530                 535                 540                 


Trp Pro Asn Ala Ser Leu Thr Gly Cys Phe Glu Leu Pro Gln Glu Tyr 
545                 550                 555                 560 


Ile Arg Trp Gly Asp Ala Trp Ala Val Gly Pro Val Thr Ile Ala Cys 
                565                 570                 575     


Leu Gly Ala Leu Ala Thr Leu Phe Val Leu Gly Val Phe Val Arg His 
            580                 585                 590         


Asn Ala Thr Pro Val Val Lys Ala Ser Gly Arg Glu Leu Cys Tyr Ile 
        595                 600                 605             


Leu Leu Gly Gly Val Phe Leu Cys Tyr Cys Met Thr Phe Ile Phe Ile 
    610                 615                 620                 


Ala Lys Pro Ser Thr Ala Val Cys Thr Leu Arg Arg Leu Gly Leu Gly 
625                 630                 635                 640 


Thr Ala Phe Ser Val Cys Tyr Ser Ala Leu Leu Thr Lys Thr Asn Arg 
                645                 650                 655     


Ile Ala Arg Ile Phe Gly Gly Ala Arg Glu Gly Ala Gln Arg Pro Arg 
            660                 665                 670         


Phe Ile Ser Pro Ala Ser Gln Val Ala Ile Cys Leu Ala Leu Ile Ser 
        675                 680                 685             


Gly Gln Leu Leu Ile Val Val Ala Trp Leu Val Val Glu Ala Pro Gly 
    690                 695                 700                 


Thr Gly Lys Glu Thr Ala Pro Glu Arg Arg Glu Val Val Thr Leu Arg 
705                 710                 715                 720 


Cys Asn His Arg Asp Ala Ser Met Leu Gly Ser Leu Ala Tyr Asn Val 
                725                 730                 735     


Leu Leu Ile Ala Leu Cys Thr Leu Tyr Ala Phe Lys Thr Arg Lys Cys 
            740                 745                 750         


Pro Glu Asn Phe Asn Glu Ala Lys Phe Ile Gly Phe Thr Met Tyr Thr 
        755                 760                 765             


Thr Cys Ile Ile Trp Leu Ala Phe Leu Pro Ile Phe Tyr Val Thr Ser 
    770                 775                 780                 


Ser Asp Tyr Arg Val Gln Thr Thr Thr Met Cys Val Ser Val Ser Leu 
785                 790                 795                 800 


Ser Gly Ser Val Val Leu Gly Cys Leu Phe Ala Pro Lys Leu His Ile 
                805                 810                 815     


Ile Leu Phe Gln Pro Gln Lys Asn Val Val Ser His Arg Ala Pro Thr 
            820                 825                 830         


Ser Arg Phe Gly Ser Ala Ala Ala Arg Ala Ser Ser Ser Leu Gly Gln 
        835                 840                 845             


Gly Ser Gly Ser Gln Phe Val Pro Thr Val Cys Asn Gly Arg Glu Val 
    850                 855                 860                 


Val Asp Ser Thr Thr Ser Ser Leu 
865                 870         


<210>  123
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  123

Met Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu Asp Ser Pro Leu 
1               5                   10                  15      


Gly Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu His Arg Ile Ile 
            20                  25                  30          


Phe Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val Glu Val Pro Ala 
        35                  40                  45              


Pro Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met Gln Ala Thr Ala 
    50                  55                  60                  


Trp Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile Glu Glu Phe Pro 
65                  70                  75                  80  


Val Pro Ala Leu His His Pro Val Phe Gln Gln Glu Ser Phe Thr Arg 
                85                  90                  95      


Gln Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe Gly Glu Val Ile 
            100                 105                 110         


Ser Tyr Ser His Leu Ala Ala Leu Ala Gly Asn Pro Ala Ala Thr Ala 
        115                 120                 125             


Ala Val Lys Thr Ala Leu Ser Gly Asn Pro Val Pro Ile Leu Ile Pro 
    130                 135                 140                 


Cys His Arg Val Val Gln Gly Asp Leu Asp Val Gly Gly Tyr Glu Gly 
145                 150                 155                 160 


Gly Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu Gly His Arg Leu 
                165                 170                 175     


Gly Lys Pro Gly Leu Gly 
            180         


<210>  124
<211>  181
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  124

Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu Asp Ser Pro Leu Gly 
1               5                   10                  15      


Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu His Glu Ile Lys Leu 
            20                  25                  30          


Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val Glu Val Pro Ala Pro 
        35                  40                  45              


Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met Gln Ala Thr Ala Trp 
    50                  55                  60                  


Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile Glu Glu Phe Pro Val 
65                  70                  75                  80  


Pro Ala Leu His His Pro Val Phe Gln Gln Glu Ser Phe Thr Arg Gln 
                85                  90                  95      


Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe Gly Glu Val Ile Ser 
            100                 105                 110         


Tyr Gln Gln Leu Ala Ala Leu Ala Gly Asn Pro Ala Ala Thr Ala Ala 
        115                 120                 125             


Val Lys Thr Ala Leu Ser Gly Asn Pro Val Pro Ile Leu Ile Pro Cys 
    130                 135                 140                 


His Arg Val Val Ser Ser Ser Gly Ala Val Gly Gly Tyr Glu Gly Gly 
145                 150                 155                 160 


Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu Gly His Arg Leu Gly 
                165                 170                 175     


Lys Pro Gly Leu Gly 
            180     


