                         SEQUENCE LISTING

<110>  Inozyme Pharma, Inc.
       Westfaelische Wilhelms-Universitaet Muenster
       Thompson, David
       Rutsch, Frank
       Nitschke, Yvonne
 
<120>  COMPOSITIONS AND METHODS FOR TREATING PERIPHERAL ARTERY DISEASE

<130>  4427-10202

<140>  Not Yet Assigned
<141>  2021-05-27

<150>  US 63/030,840
<151>  2020-05-27

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP1 Amino Acid Sequence - Wild Type

<400>  1

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Val Leu Ser Leu 
65                  70                  75                  80  


Val Leu Ser Val Cys Val Leu Thr Thr Ile Leu Gly Cys Ile Phe Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
        915                 920                 925 


<210>  2
<211>  1077
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Azurocidin-ENPP1-FC


<220>
<221>  SIGNAL
<222>  (19)..(20)
<223>  Cleavage point of the signal sequence

<220>
<221>  MISC_FEATURE
<222>  (852)..(1078)
<223>  Indicate Fc sequence

<400>  2

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Ala Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly 
            20                  25                  30          


Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys 
        35                  40                  45              


Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu 
    50                  55                  60                  


Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg 
65                  70                  75                  80  


Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly 
                85                  90                  95      


Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp 
            100                 105                 110         


Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly 
        115                 120                 125             


Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala 
    130                 135                 140                 


Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu 
145                 150                 155                 160 


Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr 
                165                 170                 175     


Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu 
            180                 185                 190         


Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala 
        195                 200                 205             


Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys 
    210                 215                 220                 


Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly 
225                 230                 235                 240 


Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro 
                245                 250                 255     


Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile 
            260                 265                 270         


Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His 
        275                 280                 285             


Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr 
    290                 295                 300                 


Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly 
305                 310                 315                 320 


Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg 
                325                 330                 335     


Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser 
            340                 345                 350         


Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn 
        355                 360                 365             


Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val 
    370                 375                 380                 


Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu 
385                 390                 395                 400 


Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe 
                405                 410                 415     


Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu 
            420                 425                 430         


Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu 
        435                 440                 445             


Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser 
    450                 455                 460                 


Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly 
465                 470                 475                 480 


Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys 
                485                 490                 495     


Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser 
            500                 505                 510         


Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys 
        515                 520                 525             


Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp 
    530                 535                 540                 


Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe 
545                 550                 555                 560 


Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His 
                565                 570                 575     


Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr 
            580                 585                 590         


Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp 
        595                 600                 605             


Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser 
    610                 615                 620                 


Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile 
625                 630                 635                 640 


Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys 
                645                 650                 655     


Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser 
            660                 665                 670         


Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr 
        675                 680                 685             


Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg 
    690                 695                 700                 


Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val 
705                 710                 715                 720 


Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg 
                725                 730                 735     


Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His 
            740                 745                 750         


Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu 
        755                 760                 765             


His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr 
    770                 775                 780                 


Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val 
785                 790                 795                 800 


Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His 
                805                 810                 815     


Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp 
            820                 825                 830         


Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Leu 
        835                 840                 845             


Ile Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    850                 855                 860                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
865                 870                 875                 880 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                885                 890                 895     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            900                 905                 910         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        915                 920                 925             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    930                 935                 940                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
945                 950                 955                 960 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                965                 970                 975     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            980                 985                 990         


Val Ser Leu Thr Cys Leu Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala 
        995                 1000                 1005             


Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr 
    1010                 1015                 1020             


Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser 
    1025                 1030                 1035             


Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe 
    1040                 1045                 1050             


Ser Cys  Ser Val Met His Glu  Ala Leu His Asn His  Tyr Thr Gln 
    1055                 1060                 1065             


Lys Ser  Leu Ser Leu Ser Pro  Gly Lys 
    1070                 1075         


<210>  3
<211>  1468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Azurocidin-ENPP1-Alb


<220>
<221>  SIGNAL
<222>  (19)..(20)
<223>  Cleavage point of the signal sequence

<220>
<221>  MISC_FEATURE
<222>  (852)..(1469)
<223>  Indicate Albumin sequence

<400>  3

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Ala Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly 
            20                  25                  30          


Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys 
        35                  40                  45              


Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu 
    50                  55                  60                  


Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg 
65                  70                  75                  80  


Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly 
                85                  90                  95      


Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp 
            100                 105                 110         


Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly 
        115                 120                 125             


Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala 
    130                 135                 140                 


Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu 
145                 150                 155                 160 


Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr 
                165                 170                 175     


Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu 
            180                 185                 190         


Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala 
        195                 200                 205             


Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys 
    210                 215                 220                 


Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly 
225                 230                 235                 240 


Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro 
                245                 250                 255     


Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile 
            260                 265                 270         


Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His 
        275                 280                 285             


Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr 
    290                 295                 300                 


Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly 
305                 310                 315                 320 


Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg 
                325                 330                 335     


Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser 
            340                 345                 350         


Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn 
        355                 360                 365             


Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val 
    370                 375                 380                 


Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu 
385                 390                 395                 400 


Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe 
                405                 410                 415     


Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu 
            420                 425                 430         


Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu 
        435                 440                 445             


Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser 
    450                 455                 460                 


Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly 
465                 470                 475                 480 


Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys 
                485                 490                 495     


Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser 
            500                 505                 510         


Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys 
        515                 520                 525             


Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp 
    530                 535                 540                 


Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe 
545                 550                 555                 560 


Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His 
                565                 570                 575     


Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr 
            580                 585                 590         


Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp 
        595                 600                 605             


Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser 
    610                 615                 620                 


Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile 
625                 630                 635                 640 


Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys 
                645                 650                 655     


Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser 
            660                 665                 670         


Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr 
        675                 680                 685             


Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg 
    690                 695                 700                 


Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val 
705                 710                 715                 720 


Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg 
                725                 730                 735     


Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His 
            740                 745                 750         


Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu 
        755                 760                 765             


His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr 
    770                 775                 780                 


Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val 
785                 790                 795                 800 


Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His 
                805                 810                 815     


Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp 
            820                 825                 830         


Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Leu 
        835                 840                 845             


Ile Asn Met Lys Trp Val Thr Phe Leu Leu Leu Leu Phe Val Ser Gly 
    850                 855                 860                 


Ser Ala Phe Ser Arg Gly Val Phe Arg Arg Glu Ala His Lys Ser Glu 
865                 870                 875                 880 


Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu 
                885                 890                 895     


Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu 
            900                 905                 910         


His Ala Lys Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val 
        915                 920                 925             


Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
    930                 935                 940                 


Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu 
945                 950                 955                 960 


Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
                965                 970                 975     


Leu Gln His Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro 
            980                 985                 990         


Glu Ala Glu Ala Met Cys Thr Ser  Phe Lys Glu Asn Pro  Thr Thr Phe 
        995                 1000                 1005             


Met Gly  His Tyr Leu His Glu  Val Ala Arg Arg His  Pro Tyr Phe 
    1010                 1015                 1020             


Tyr Ala  Pro Glu Leu Leu Tyr  Tyr Ala Glu Gln Tyr  Asn Glu Ile 
    1025                 1030                 1035             


Leu Thr  Gln Cys Cys Ala Glu  Ala Asp Lys Glu Ser  Cys Leu Thr 
    1040                 1045                 1050             


Pro Lys  Leu Asp Gly Val Lys  Glu Lys Ala Leu Val  Ser Ser Val 
    1055                 1060                 1065             


Arg Gln  Arg Met Lys Cys Ser  Ser Met Gln Lys Phe  Gly Glu Arg 
    1070                 1075                 1080             


Ala Phe  Lys Ala Trp Ala Val  Ala Arg Leu Ser Gln  Thr Phe Pro 
    1085                 1090                 1095             


Asn Ala  Asp Phe Ala Glu Ile  Thr Lys Leu Ala Thr  Asp Leu Thr 
    1100                 1105                 1110             


Lys Val  Asn Lys Glu Cys Cys  His Gly Asp Leu Leu  Glu Cys Ala 
    1115                 1120                 1125             


Asp Asp  Arg Ala Glu Leu Ala  Lys Tyr Met Cys Glu  Asn Gln Ala 
    1130                 1135                 1140             


Thr Ile  Ser Ser Lys Leu Gln  Thr Cys Cys Asp Lys  Pro Leu Leu 
    1145                 1150                 1155             


Lys Lys  Ala His Cys Leu Ser  Glu Val Glu His Asp  Thr Met Pro 
    1160                 1165                 1170             


Ala Asp  Leu Pro Ala Ile Ala  Ala Asp Phe Val Glu  Asp Gln Glu 
    1175                 1180                 1185             


Val Cys  Lys Asn Tyr Ala Glu  Ala Lys Asp Val Phe  Leu Gly Thr 
    1190                 1195                 1200             


Phe Leu  Tyr Glu Tyr Ser Arg  Arg His Pro Asp Tyr  Ser Val Ser 
    1205                 1210                 1215             


Leu Leu  Leu Arg Leu Ala Lys  Lys Tyr Glu Ala Thr  Leu Glu Lys 
    1220                 1225                 1230             


Cys Cys  Ala Glu Ala Asn Pro  Pro Ala Cys Tyr Gly  Thr Val Leu 
    1235                 1240                 1245             


Ala Glu  Phe Gln Pro Leu Val  Glu Glu Pro Lys Asn  Leu Val Lys 
    1250                 1255                 1260             


Thr Asn  Cys Asp Leu Tyr Glu  Lys Leu Gly Glu Tyr  Gly Phe Gln 
    1265                 1270                 1275             


Asn Ala  Ile Leu Val Arg Tyr  Thr Gln Lys Ala Pro  Gln Val Ser 
    1280                 1285                 1290             


Thr Pro  Thr Leu Val Glu Ala  Ala Arg Asn Leu Gly  Arg Val Gly 
    1295                 1300                 1305             


Thr Lys  Cys Cys Thr Leu Pro  Glu Asp Gln Arg Leu  Pro Cys Val 
    1310                 1315                 1320             


Glu Asp  Tyr Leu Ser Ala Ile  Leu Asn Arg Val Cys  Leu Leu His 
    1325                 1330                 1335             


Glu Lys  Thr Pro Val Ser Glu  His Val Thr Lys Cys  Cys Ser Gly 
    1340                 1345                 1350             


Ser Leu  Val Glu Arg Arg Pro  Cys Phe Ser Ala Leu  Thr Val Asp 
    1355                 1360                 1365             


Glu Thr  Tyr Val Pro Lys Glu  Phe Lys Ala Glu Thr  Phe Thr Phe 
    1370                 1375                 1380             


His Ser  Asp Ile Cys Thr Leu  Pro Glu Lys Glu Lys  Gln Ile Lys 
    1385                 1390                 1395             


Lys Gln  Thr Ala Leu Ala Glu  Leu Val Lys His Lys  Pro Lys Ala 
    1400                 1405                 1410             


Thr Ala  Glu Gln Leu Lys Thr  Val Met Asp Asp Phe  Ala Gln Phe 
    1415                 1420                 1425             


Leu Asp  Thr Cys Cys Lys Ala  Ala Asp Lys Asp Thr  Cys Phe Ser 
    1430                 1435                 1440             


Thr Glu  Gly Pro Asn Leu Val  Thr Arg Cys Lys Asp  Ala Leu Ala 
    1445                 1450                 1455             


Arg Ser  Trp Ser His Pro Gln  Phe Glu Lys 
    1460                 1465             


<210>  4
<211>  1594
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Azurocidin-ENPP1


<220>
<221>  SIGNAL
<222>  (19)..(20)
<223>  Cleavage point of the signal sequence

<400>  4

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Ala Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly 
            20                  25                  30          


Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys 
        35                  40                  45              


Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu 
    50                  55                  60                  


Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg 
65                  70                  75                  80  


Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly 
                85                  90                  95      


Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp 
            100                 105                 110         


Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly 
        115                 120                 125             


Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala 
    130                 135                 140                 


Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu 
145                 150                 155                 160 


Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr 
                165                 170                 175     


Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu 
            180                 185                 190         


Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala 
        195                 200                 205             


Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys 
    210                 215                 220                 


Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly 
225                 230                 235                 240 


Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro 
                245                 250                 255     


Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile 
            260                 265                 270         


Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His 
        275                 280                 285             


Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr 
    290                 295                 300                 


Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly 
305                 310                 315                 320 


Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg 
                325                 330                 335     


Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser 
            340                 345                 350         


Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn 
        355                 360                 365             


Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val 
    370                 375                 380                 


Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu 
385                 390                 395                 400 


Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe 
                405                 410                 415     


Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu 
            420                 425                 430         


Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu 
        435                 440                 445             


Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser 
    450                 455                 460                 


Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly 
465                 470                 475                 480 


Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys 
                485                 490                 495     


Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser 
            500                 505                 510         


Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys 
        515                 520                 525             


Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp 
    530                 535                 540                 


Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe 
545                 550                 555                 560 


Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His 
                565                 570                 575     


Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr 
            580                 585                 590         


Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp 
        595                 600                 605             


Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser 
    610                 615                 620                 


Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile 
625                 630                 635                 640 


Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys 
                645                 650                 655     


Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser 
            660                 665                 670         


Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr 
        675                 680                 685             


Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg 
    690                 695                 700                 


Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val 
705                 710                 715                 720 


Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg 
                725                 730                 735     


Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His 
            740                 745                 750         


Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Ala Pro 
        755                 760                 765             


Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys Phe Glu Arg 
    770                 775                 780                 


Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu Leu Gly Asn 
785                 790                 795                 800 


Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu His Ile Trp 
                805                 810                 815     


Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr Arg Ser Leu 
            820                 825                 830         


Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys Cys Ile Asn 
        835                 840                 845             


Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu Glu Pro Cys 
    850                 855                 860                 


Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu Thr Pro Pro 
865                 870                 875                 880 


Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr Leu His Thr 
                885                 890                 895     


Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys Cys Gly Thr 
            900                 905                 910         


Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn 
        915                 920                 925             


His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile 
    930                 935                 940                 


Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe Ser Leu Lys 
945                 950                 955                 960 


Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu Pro Ile Trp 
                965                 970                 975     


Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe Phe Trp Pro 
            980                 985                 990         


Gly Ser Asp Val Glu Ile Asn Gly  Ile Phe Pro Asp Ile  Tyr Lys Met 
        995                 1000                 1005             


Tyr Asn  Gly Ser Val Pro Phe  Glu Glu Arg Ile Leu  Ala Val Leu 
    1010                 1015                 1020             


Gln Trp  Leu Gln Leu Pro Lys  Asp Glu Arg Pro His  Phe Tyr Thr 
    1025                 1030                 1035             


Leu Tyr  Leu Glu Glu Pro Asp  Ser Ser Gly His Ser  Tyr Gly Pro 
    1040                 1045                 1050             


Val Ser  Ser Glu Val Ile Lys  Ala Leu Gln Arg Val  Asp Gly Met 
    1055                 1060                 1065             


Val Gly  Met Leu Met Asp Gly  Leu Lys Glu Leu Asn  Leu His Arg 
    1070                 1075                 1080             


Cys Leu  Asn Leu Ile Leu Ile  Ser Asp His Gly Met  Glu Gln Gly 
    1085                 1090                 1095             


Ser Cys  Lys Lys Tyr Ile Tyr  Leu Asn Lys Tyr Leu  Gly Asp Val 
    1100                 1105                 1110             


Lys Asn  Ile Lys Val Ile Tyr  Gly Pro Ala Ala Arg  Leu Arg Pro 
    1115                 1120                 1125             


Ser Asp  Val Pro Asp Lys Tyr  Tyr Ser Phe Asn Tyr  Glu Gly Ile 
    1130                 1135                 1140             


Ala Arg  Asn Leu Ser Cys Arg  Glu Pro Asn Gln His  Phe Lys Pro 
    1145                 1150                 1155             


Tyr Leu  Lys His Phe Leu Pro  Lys Arg Leu His Phe  Ala Lys Ser 
    1160                 1165                 1170             


Asp Arg  Ile Glu Pro Leu Thr  Phe Tyr Leu Asp Pro  Gln Trp Gln 
    1175                 1180                 1185             


Leu Ala  Leu Asn Pro Ser Glu  Arg Lys Tyr Cys Gly  Ser Gly Phe 
    1190                 1195                 1200             


His Gly  Ser Asp Asn Val Phe  Ser Asn Met Gln Ala  Leu Phe Val 
    1205                 1210                 1215             


Gly Tyr  Gly Pro Gly Phe Lys  His Gly Ile Glu Ala  Asp Thr Phe 
    1220                 1225                 1230             


Glu Asn  Ile Glu Val Tyr Asn  Leu Met Cys Asp Leu  Leu Asn Leu 
    1235                 1240                 1245             


Thr Pro  Ala Pro Asn Asn Gly  Thr His Gly Ser Leu  Asn His Leu 
    1250                 1255                 1260             


Leu Lys  Asn Pro Val Tyr Thr  Pro Lys His Pro Lys  Glu Val His 
    1265                 1270                 1275             


Pro Leu  Val Gln Cys Pro Phe  Thr Arg Asn Pro Arg  Asp Asn Leu 
    1280                 1285                 1290             


Gly Cys  Ser Cys Asn Pro Ser  Ile Leu Pro Ile Glu  Asp Phe Gln 
    1295                 1300                 1305             


Thr Gln  Phe Asn Leu Thr Val  Ala Glu Glu Lys Ile  Ile Lys His 
    1310                 1315                 1320             


Glu Thr  Leu Pro Tyr Gly Arg  Pro Arg Val Leu Gln  Lys Glu Asn 
    1325                 1330                 1335             


Thr Ile  Cys Leu Leu Ser Gln  His Gln Phe Met Ser  Gly Tyr Ser 
    1340                 1345                 1350             


Gln Asp  Ile Leu Met Pro Leu  Trp Thr Ser Tyr Thr  Val Asp Arg 
    1355                 1360                 1365             


Asn Asp  Ser Phe Ser Thr Glu  Asp Phe Ser Asn Cys  Leu Tyr Gln 
    1370                 1375                 1380             


Asp Phe  Arg Ile Pro Leu Ser  Pro Val His Lys Cys  Ser Phe Tyr 
    1385                 1390                 1395             


Lys Asn  Asn Thr Lys Val Ser  Tyr Gly Phe Leu Ser  Pro Pro Gln 
    1400                 1405                 1410             


Leu Asn  Lys Asn Ser Ser Gly  Ile Tyr Ser Glu Ala  Leu Leu Thr 
    1415                 1420                 1425             


Thr Asn  Ile Val Pro Met Tyr  Gln Ser Phe Gln Val  Ile Trp Arg 
    1430                 1435                 1440             


Tyr Phe  His Asp Thr Leu Leu  Arg Lys Tyr Ala Glu  Glu Arg Asn 
    1445                 1450                 1455             


Gly Val  Asn Val Val Ser Gly  Pro Val Phe Asp Phe  Asp Tyr Asp 
    1460                 1465                 1470             


Gly Arg  Cys Asp Ser Leu Glu  Asn Leu Arg Gln Lys  Arg Arg Val 
    1475                 1480                 1485             


Ile Arg  Asn Gln Glu Ile Leu  Ile Pro Thr His Phe  Phe Ile Val 
    1490                 1495                 1500             


Leu Thr  Ser Cys Lys Asp Thr  Ser Gln Thr Pro Leu  His Cys Glu 
    1505                 1510                 1515             


Asn Leu  Asp Thr Leu Ala Phe  Ile Leu Pro His Arg  Thr Asp Asn 
    1520                 1525                 1530             


Ser Glu  Ser Cys Val His Gly  Lys His Asp Ser Ser  Trp Val Glu 
    1535                 1540                 1545             


Glu Leu  Leu Met Leu His Arg  Ala Arg Ile Thr Asp  Val Glu His 
    1550                 1555                 1560             


Ile Thr  Gly Leu Ser Phe Tyr  Gln Gln Arg Lys Glu  Pro Val Ser 
    1565                 1570                 1575             


Asp Ile  Leu Lys Leu Lys Thr  His Leu Pro Thr Phe  Ser Gln Glu 
    1580                 1585                 1590             


Asp 
    


<210>  5
<211>  888
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP2 Amino Acid Sequence - Wild Type

<400>  5

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Ile Val 
                325                 330                 335     


Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val 
            340                 345                 350         


Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp 
        355                 360                 365             


Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr 
    370                 375                 380                 


Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys Phe Ser Asn Asn 
385                 390                 395                 400 


Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys 
                405                 410                 415     


Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His Leu Pro Lys Arg 
            420                 425                 430         


Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile His Leu Leu Val 
        435                 440                 445             


Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys 
    450                 455                 460                 


Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys 
465                 470                 475                 480 


Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Ser Thr Phe Lys 
                485                 490                 495     


Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val 
            500                 505                 510         


Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His 
        515                 520                 525             


Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Met 
    530                 535                 540                 


Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln 
545                 550                 555                 560 


Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys 
                565                 570                 575     


Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr 
            580                 585                 590         


Glu Ala Glu Thr Arg Lys Phe Arg Gly Ser Arg Asn Glu Asn Lys Glu 
        595                 600                 605             


Asn Ile Asn Gly Asn Phe Glu Pro Arg Lys Glu Arg His Leu Leu Tyr 
    610                 615                 620                 


Gly Arg Pro Ala Val Leu Tyr Arg Thr Arg Tyr Asp Ile Leu Tyr His 
625                 630                 635                 640 


Thr Asp Phe Glu Ser Gly Tyr Ser Glu Ile Phe Leu Met Pro Leu Trp 
                645                 650                 655     


Thr Ser Tyr Thr Val Ser Lys Gln Ala Glu Val Ser Ser Val Pro Asp 
            660                 665                 670         


His Leu Thr Ser Cys Val Arg Pro Asp Val Arg Val Ser Pro Ser Phe 
        675                 680                 685             


Ser Gln Asn Cys Leu Ala Tyr Lys Asn Asp Lys Gln Met Ser Tyr Gly 
    690                 695                 700                 


Phe Leu Phe Pro Pro Tyr Leu Ser Ser Ser Pro Glu Ala Lys Tyr Asp 
705                 710                 715                 720 


Ala Phe Leu Val Thr Asn Met Val Pro Met Tyr Pro Ala Phe Lys Arg 
                725                 730                 735     


Val Trp Asn Tyr Phe Gln Arg Val Leu Val Lys Lys Tyr Ala Ser Glu 
            740                 745                 750         


Arg Asn Gly Val Asn Val Ile Ser Gly Pro Ile Phe Asp Tyr Asp Tyr 
        755                 760                 765             


Asp Gly Leu His Asp Thr Glu Asp Lys Ile Lys Gln Tyr Val Glu Gly 
    770                 775                 780                 


Ser Ser Ile Pro Val Pro Thr His Tyr Tyr Ser Ile Ile Thr Ser Cys 
785                 790                 795                 800 


Leu Asp Phe Thr Gln Pro Ala Asp Lys Cys Asp Gly Pro Leu Ser Val 
                805                 810                 815     


Ser Ser Phe Ile Leu Pro His Arg Pro Asp Asn Glu Glu Ser Cys Asn 
            820                 825                 830         


Ser Ser Glu Asp Glu Ser Lys Trp Val Glu Glu Leu Met Lys Met His 
        835                 840                 845             


Thr Ala Arg Val Arg Asp Ile Glu His Leu Thr Ser Leu Asp Phe Phe 
    850                 855                 860                 


Arg Lys Thr Ser Arg Ser Tyr Pro Glu Ile Leu Thr Leu Lys Thr Tyr 
865                 870                 875                 880 


Leu His Thr Tyr Glu Ser Glu Ile 
                885             


<210>  6
<211>  827
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Extracellular Domain of ENPP3

<400>  6

Glu Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg 
1               5                   10                  15      


Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp 
            20                  25                  30          


Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp 
        35                  40                  45              


Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu Ala Ser Leu 
    50                  55                  60                  


Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Ala Asp 
65                  70                  75                  80  


Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys 
                85                  90                  95      


Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro 
            100                 105                 110         


Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr 
        115                 120                 125             


Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile 
    130                 135                 140                 


His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn 
145                 150                 155                 160 


His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile 
                165                 170                 175     


Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser 
            180                 185                 190         


Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp 
        195                 200                 205             


Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro 
    210                 215                 220                 


Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro 
225                 230                 235                 240 


Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys 
                245                 250                 255     


Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr 
            260                 265                 270         


Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala 
        275                 280                 285             


Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu 
    290                 295                 300                 


Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile 
305                 310                 315                 320 


Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu 
                325                 330                 335     


Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu 
            340                 345                 350         


Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe 
        355                 360                 365             


Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro 
    370                 375                 380                 


Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
385                 390                 395                 400 


His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp 
                405                 410                 415     


Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly 
            420                 425                 430         


Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe 
        435                 440                 445             


Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe 
    450                 455                 460                 


Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln 
465                 470                 475                 480 


Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys 
                485                 490                 495     


Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser 
            500                 505                 510         


Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe 
        515                 520                 525             


Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met 
    530                 535                 540                 


Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu 
545                 550                 555                 560 


Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu 
                565                 570                 575     


Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met 
            580                 585                 590         


Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro 
        595                 600                 605             


Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro 
    610                 615                 620                 


Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile 
625                 630                 635                 640 


Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser 
                645                 650                 655     


Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu 
            660                 665                 670         


Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His 
        675                 680                 685             


Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
    690                 695                 700                 


Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His 
705                 710                 715                 720 


Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu 
                725                 730                 735     


Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp 
            740                 745                 750         


Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu 
        755                 760                 765             


Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe 
    770                 775                 780                 


Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu 
785                 790                 795                 800 


Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu 
                805                 810                 815     


Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile 
            820                 825         


<210>  7
<211>  875
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NPP3 Amino Acid Sequence

<400>  7

Met Glu Ser Thr Leu Thr Leu Ala Thr Glu Gln Pro Val Lys Lys Asn 
1               5                   10                  15      


Thr Leu Lys Lys Tyr Lys Ile Ala Cys Ile Val Leu Leu Ala Leu Leu 
            20                  25                  30          


Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys Leu 
        35                  40                  45              


Glu Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg 
    50                  55                  60                  


Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp 
65                  70                  75                  80  


Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp 
                85                  90                  95      


Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu Ala Ser Leu 
            100                 105                 110         


Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Ala Asp 
        115                 120                 125             


Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys 
    130                 135                 140                 


Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro 
145                 150                 155                 160 


Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr 
                165                 170                 175     


Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile 
            180                 185                 190         


His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn 
        195                 200                 205             


His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile 
    210                 215                 220                 


Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser 
225                 230                 235                 240 


Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp 
                245                 250                 255     


Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro 
            260                 265                 270         


Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro 
        275                 280                 285             


Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys 
    290                 295                 300                 


Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr 
305                 310                 315                 320 


Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala 
                325                 330                 335     


Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu 
            340                 345                 350         


Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile 
        355                 360                 365             


Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu 
    370                 375                 380                 


Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu 
385                 390                 395                 400 


Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe 
                405                 410                 415     


Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro 
            420                 425                 430         


Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
        435                 440                 445             


His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp 
    450                 455                 460                 


Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly 
465                 470                 475                 480 


Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe 
                485                 490                 495     


Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe 
            500                 505                 510         


Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln 
        515                 520                 525             


Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys 
    530                 535                 540                 


Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser 
545                 550                 555                 560 


Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe 
                565                 570                 575     


Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met 
            580                 585                 590         


Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu 
        595                 600                 605             


Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu 
    610                 615                 620                 


Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met 
625                 630                 635                 640 


Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro 
                645                 650                 655     


Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro 
            660                 665                 670         


Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile 
        675                 680                 685             


Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser 
    690                 695                 700                 


Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu 
705                 710                 715                 720 


Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His 
                725                 730                 735     


Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
            740                 745                 750         


Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His 
        755                 760                 765             


Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu 
    770                 775                 780                 


Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp 
785                 790                 795                 800 


Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu 
                805                 810                 815     


Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe 
            820                 825                 830         


Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu 
        835                 840                 845             


Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu 
    850                 855                 860                 


Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile 
865                 870                 875 


<210>  8
<211>  1073
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Azurocidin-ENPP3-FC


<220>
<221>  SIGNAL
<222>  (19)..(20)
<223>  Cleavage point of the signal sequence

<220>
<221>  MISC_FEATURE
<222>  (847)..(1074)
<223>  Indicate Fc sequence

<220>
<221>  MISC_FEATURE
<222>  (848)..(1074)
<223>  Indicate Fc sequence

<400>  8

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Ala Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala 
            20                  25                  30          


Ser Phe Arg Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp 
        35                  40                  45              


Arg Gly Asp Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr 
    50                  55                  60                  


Arg Ile Trp Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu 
65                  70                  75                  80  


Ala Ser Leu Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys 
                85                  90                  95      


Cys Ala Asp Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu 
            100                 105                 110         


Glu Asn Cys Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp 
        115                 120                 125             


Leu Pro Pro Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr 
    130                 135                 140                 


Leu Tyr Thr Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr 
145                 150                 155                 160 


Cys Gly Ile His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr 
                165                 170                 175     


Phe Pro Asn His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            180                 185                 190         


Gly Ile Ile Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe 
        195                 200                 205             


Ser Leu Ser Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln 
    210                 215                 220                 


Pro Met Asn Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr 
225                 230                 235                 240 


Phe Trp Pro Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile 
                245                 250                 255     


Tyr Met Pro Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr 
            260                 265                 270         


Leu Leu Lys Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr 
        275                 280                 285             


Thr Met Tyr Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro 
    290                 295                 300                 


Val Ser Ala Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe 
305                 310                 315                 320 


Gly Met Leu Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val 
                325                 330                 335     


Asn Ile Ile Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn 
            340                 345                 350         


Lys Met Glu Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr 
        355                 360                 365             


Met Tyr Glu Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His 
    370                 375                 380                 


Asp Phe Phe Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys 
385                 390                 395                 400 


Arg Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro 
                405                 410                 415     


Lys Arg Leu His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu 
            420                 425                 430         


Phe Val Asp Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn 
        435                 440                 445             


Cys Gly Gly Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu 
    450                 455                 460                 


Ala Ile Phe Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val 
465                 470                 475                 480 


Glu Pro Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu 
                485                 490                 495     


Arg Ile Gln Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His 
            500                 505                 510         


Leu Leu Lys Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser 
        515                 520                 525             


Lys Phe Ser Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu 
    530                 535                 540                 


Asp Cys Phe Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val 
545                 550                 555                 560 


Asn Gln Met Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys 
                565                 570                 575     


Val Asn Leu Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp 
            580                 585                 590         


His Cys Leu Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala 
        595                 600                 605             


Met Arg Met Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp 
    610                 615                 620                 


Thr Ser Pro Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val 
625                 630                 635                 640 


Arg Val Pro Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp 
                645                 650                 655     


Lys Asn Ile Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr 
            660                 665                 670         


Ser Asp Ser Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met 
        675                 680                 685             


Tyr Glu Glu Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu 
    690                 695                 700                 


Ile Lys His Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro 
705                 710                 715                 720 


Ile Phe Asp Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile 
                725                 730                 735     


Thr Lys His Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe 
            740                 745                 750         


Val Val Leu Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys 
        755                 760                 765             


Pro Gly Trp Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr 
    770                 775                 780                 


Asn Val Glu Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu 
785                 790                 795                 800 


Glu Arg Phe Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu 
                805                 810                 815     


Thr Gly Leu Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile 
            820                 825                 830         


Leu Gln Leu Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile Asp Lys 
        835                 840                 845             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    850                 855                 860                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
865                 870                 875                 880 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                885                 890                 895     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            900                 905                 910         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        915                 920                 925             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    930                 935                 940                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
945                 950                 955                 960 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                965                 970                 975     


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            980                 985                 990         


Cys Leu Val Lys Gly Phe Tyr Pro  Ser Asp Ile Ala Val  Glu Trp Glu 
        995                 1000                 1005             


Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys Thr Thr  Pro Pro Val 
    1010                 1015                 1020             


Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr Ser Lys  Leu Thr Val 
    1025                 1030                 1035             


Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val Phe Ser  Cys Ser Val 
    1040                 1045                 1050             


Met His  Glu Ala Leu His Asn  His Tyr Thr Gln Lys  Ser Leu Ser 
    1055                 1060                 1065             


Leu Ser  Pro Gly Lys 
    1070             


<210>  9
<211>  1464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Azurocidin-ENPP3-Albumin


<220>
<221>  SIGNAL
<222>  (19)..(20)
<223>  Cleavage point of the signal sequence

<220>
<221>  MISC_FEATURE
<222>  (848)..(1465)
<223>  Indicate Albumin sequence

<400>  9

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Ala Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala 
            20                  25                  30          


Ser Phe Arg Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp 
        35                  40                  45              


Arg Gly Asp Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr 
    50                  55                  60                  


Arg Ile Trp Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu 
65                  70                  75                  80  


Ala Ser Leu Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys 
                85                  90                  95      


Cys Ala Asp Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu 
            100                 105                 110         


Glu Asn Cys Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp 
        115                 120                 125             


Leu Pro Pro Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr 
    130                 135                 140                 


Leu Tyr Thr Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr 
145                 150                 155                 160 


Cys Gly Ile His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr 
                165                 170                 175     


Phe Pro Asn His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            180                 185                 190         


Gly Ile Ile Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe 
        195                 200                 205             


Ser Leu Ser Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln 
    210                 215                 220                 


Pro Met Asn Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr 
225                 230                 235                 240 


Phe Trp Pro Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile 
                245                 250                 255     


Tyr Met Pro Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr 
            260                 265                 270         


Leu Leu Lys Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr 
        275                 280                 285             


Thr Met Tyr Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro 
    290                 295                 300                 


Val Ser Ala Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe 
305                 310                 315                 320 


Gly Met Leu Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val 
                325                 330                 335     


Asn Ile Ile Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn 
            340                 345                 350         


Lys Met Glu Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr 
        355                 360                 365             


Met Tyr Glu Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His 
    370                 375                 380                 


Asp Phe Phe Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys 
385                 390                 395                 400 


Arg Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro 
                405                 410                 415     


Lys Arg Leu His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu 
            420                 425                 430         


Phe Val Asp Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn 
        435                 440                 445             


Cys Gly Gly Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu 
    450                 455                 460                 


Ala Ile Phe Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val 
465                 470                 475                 480 


Glu Pro Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu 
                485                 490                 495     


Arg Ile Gln Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His 
            500                 505                 510         


Leu Leu Lys Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser 
        515                 520                 525             


Lys Phe Ser Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu 
    530                 535                 540                 


Asp Cys Phe Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val 
545                 550                 555                 560 


Asn Gln Met Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys 
                565                 570                 575     


Val Asn Leu Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp 
            580                 585                 590         


His Cys Leu Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala 
        595                 600                 605             


Met Arg Met Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp 
    610                 615                 620                 


Thr Ser Pro Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val 
625                 630                 635                 640 


Arg Val Pro Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp 
                645                 650                 655     


Lys Asn Ile Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr 
            660                 665                 670         


Ser Asp Ser Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met 
        675                 680                 685             


Tyr Glu Glu Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu 
    690                 695                 700                 


Ile Lys His Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro 
705                 710                 715                 720 


Ile Phe Asp Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile 
                725                 730                 735     


Thr Lys His Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe 
            740                 745                 750         


Val Val Leu Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys 
        755                 760                 765             


Pro Gly Trp Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr 
    770                 775                 780                 


Asn Val Glu Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu 
785                 790                 795                 800 


Glu Arg Phe Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu 
                805                 810                 815     


Thr Gly Leu Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile 
            820                 825                 830         


Leu Gln Leu Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile Met Lys 
        835                 840                 845             


Trp Val Thr Phe Leu Leu Leu Leu Phe Val Ser Gly Ser Ala Phe Ser 
    850                 855                 860                 


Arg Gly Val Phe Arg Arg Glu Ala His Lys Ser Glu Ile Ala His Arg 
865                 870                 875                 880 


Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile Ala 
                885                 890                 895     


Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys Leu 
            900                 905                 910         


Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 
        915                 920                 925             


Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 
    930                 935                 940                 


Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys 
945                 950                 955                 960 


Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 
                965                 970                 975     


Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala 
            980                 985                 990         


Met Cys Thr Ser Phe Lys Glu Asn  Pro Thr Thr Phe Met  Gly His Tyr 
        995                 1000                 1005             


Leu His  Glu Val Ala Arg Arg  His Pro Tyr Phe Tyr  Ala Pro Glu 
    1010                 1015                 1020             


Leu Leu  Tyr Tyr Ala Glu Gln  Tyr Asn Glu Ile Leu  Thr Gln Cys 
    1025                 1030                 1035             


Cys Ala  Glu Ala Asp Lys Glu  Ser Cys Leu Thr Pro  Lys Leu Asp 
    1040                 1045                 1050             


Gly Val  Lys Glu Lys Ala Leu  Val Ser Ser Val Arg  Gln Arg Met 
    1055                 1060                 1065             


Lys Cys  Ser Ser Met Gln Lys  Phe Gly Glu Arg Ala  Phe Lys Ala 
    1070                 1075                 1080             


Trp Ala  Val Ala Arg Leu Ser  Gln Thr Phe Pro Asn  Ala Asp Phe 
    1085                 1090                 1095             


Ala Glu  Ile Thr Lys Leu Ala  Thr Asp Leu Thr Lys  Val Asn Lys 
    1100                 1105                 1110             


Glu Cys  Cys His Gly Asp Leu  Leu Glu Cys Ala Asp  Asp Arg Ala 
    1115                 1120                 1125             


Glu Leu  Ala Lys Tyr Met Cys  Glu Asn Gln Ala Thr  Ile Ser Ser 
    1130                 1135                 1140             


Lys Leu  Gln Thr Cys Cys Asp  Lys Pro Leu Leu Lys  Lys Ala His 
    1145                 1150                 1155             


Cys Leu  Ser Glu Val Glu His  Asp Thr Met Pro Ala  Asp Leu Pro 
    1160                 1165                 1170             


Ala Ile  Ala Ala Asp Phe Val  Glu Asp Gln Glu Val  Cys Lys Asn 
    1175                 1180                 1185             


Tyr Ala  Glu Ala Lys Asp Val  Phe Leu Gly Thr Phe  Leu Tyr Glu 
    1190                 1195                 1200             


Tyr Ser  Arg Arg His Pro Asp  Tyr Ser Val Ser Leu  Leu Leu Arg 
    1205                 1210                 1215             


Leu Ala  Lys Lys Tyr Glu Ala  Thr Leu Glu Lys Cys  Cys Ala Glu 
    1220                 1225                 1230             


Ala Asn  Pro Pro Ala Cys Tyr  Gly Thr Val Leu Ala  Glu Phe Gln 
    1235                 1240                 1245             


Pro Leu  Val Glu Glu Pro Lys  Asn Leu Val Lys Thr  Asn Cys Asp 
    1250                 1255                 1260             


Leu Tyr  Glu Lys Leu Gly Glu  Tyr Gly Phe Gln Asn  Ala Ile Leu 
    1265                 1270                 1275             


Val Arg  Tyr Thr Gln Lys Ala  Pro Gln Val Ser Thr  Pro Thr Leu 
    1280                 1285                 1290             


Val Glu  Ala Ala Arg Asn Leu  Gly Arg Val Gly Thr  Lys Cys Cys 
    1295                 1300                 1305             


Thr Leu  Pro Glu Asp Gln Arg  Leu Pro Cys Val Glu  Asp Tyr Leu 
    1310                 1315                 1320             


Ser Ala  Ile Leu Asn Arg Val  Cys Leu Leu His Glu  Lys Thr Pro 
    1325                 1330                 1335             


Val Ser  Glu His Val Thr Lys  Cys Cys Ser Gly Ser  Leu Val Glu 
    1340                 1345                 1350             


Arg Arg  Pro Cys Phe Ser Ala  Leu Thr Val Asp Glu  Thr Tyr Val 
    1355                 1360                 1365             


Pro Lys  Glu Phe Lys Ala Glu  Thr Phe Thr Phe His  Ser Asp Ile 
    1370                 1375                 1380             


Cys Thr  Leu Pro Glu Lys Glu  Lys Gln Ile Lys Lys  Gln Thr Ala 
    1385                 1390                 1395             


Leu Ala  Glu Leu Val Lys His  Lys Pro Lys Ala Thr  Ala Glu Gln 
    1400                 1405                 1410             


Leu Lys  Thr Val Met Asp Asp  Phe Ala Gln Phe Leu  Asp Thr Cys 
    1415                 1420                 1425             


Cys Lys  Ala Ala Asp Lys Asp  Thr Cys Phe Ser Thr  Glu Gly Pro 
    1430                 1435                 1440             


Asn Leu  Val Thr Arg Cys Lys  Asp Ala Leu Ala Arg  Ser Trp Ser 
    1445                 1450                 1455             


His Pro  Gln Phe Glu Lys 
    1460                 


<210>  10
<211>  846
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Azurocidin-ENPP3


<220>
<221>  SIGNAL
<222>  (19)..(20)
<223>  Cleavage point of the signal sequence

<400>  10

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Ala Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala 
            20                  25                  30          


Ser Phe Arg Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp 
        35                  40                  45              


Arg Gly Asp Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr 
    50                  55                  60                  


Arg Ile Trp Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu 
65                  70                  75                  80  


Ala Ser Leu Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys 
                85                  90                  95      


Cys Ala Asp Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu 
            100                 105                 110         


Glu Asn Cys Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp 
        115                 120                 125             


Leu Pro Pro Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr 
    130                 135                 140                 


Leu Tyr Thr Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr 
145                 150                 155                 160 


Cys Gly Ile His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr 
                165                 170                 175     


Phe Pro Asn His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            180                 185                 190         


Gly Ile Ile Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe 
        195                 200                 205             


Ser Leu Ser Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln 
    210                 215                 220                 


Pro Met Asn Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr 
225                 230                 235                 240 


Phe Trp Pro Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile 
                245                 250                 255     


Tyr Met Pro Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr 
            260                 265                 270         


Leu Leu Lys Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr 
        275                 280                 285             


Thr Met Tyr Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro 
    290                 295                 300                 


Val Ser Ala Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe 
305                 310                 315                 320 


Gly Met Leu Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val 
                325                 330                 335     


Asn Ile Ile Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn 
            340                 345                 350         


Lys Met Glu Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr 
        355                 360                 365             


Met Tyr Glu Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His 
    370                 375                 380                 


Asp Phe Phe Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys 
385                 390                 395                 400 


Arg Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro 
                405                 410                 415     


Lys Arg Leu His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu 
            420                 425                 430         


Phe Val Asp Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn 
        435                 440                 445             


Cys Gly Gly Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu 
    450                 455                 460                 


Ala Ile Phe Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val 
465                 470                 475                 480 


Glu Pro Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu 
                485                 490                 495     


Arg Ile Gln Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His 
            500                 505                 510         


Leu Leu Lys Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser 
        515                 520                 525             


Lys Phe Ser Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu 
    530                 535                 540                 


Asp Cys Phe Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val 
545                 550                 555                 560 


Asn Gln Met Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys 
                565                 570                 575     


Val Asn Leu Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp 
            580                 585                 590         


His Cys Leu Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala 
        595                 600                 605             


Met Arg Met Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp 
    610                 615                 620                 


Thr Ser Pro Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val 
625                 630                 635                 640 


Arg Val Pro Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp 
                645                 650                 655     


Lys Asn Ile Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr 
            660                 665                 670         


Ser Asp Ser Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met 
        675                 680                 685             


Tyr Glu Glu Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu 
    690                 695                 700                 


Ile Lys His Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro 
705                 710                 715                 720 


Ile Phe Asp Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile 
                725                 730                 735     


Thr Lys His Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe 
            740                 745                 750         


Val Val Leu Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys 
        755                 760                 765             


Pro Gly Trp Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr 
    770                 775                 780                 


Asn Val Glu Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu 
785                 790                 795                 800 


Glu Arg Phe Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu 
                805                 810                 815     


Thr Gly Leu Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile 
            820                 825                 830         


Leu Gln Leu Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile 
        835                 840                 845     


<210>  11
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP4 Amino Acid Sequence - Wild Type

<400>  11

Met Lys Leu Leu Val Ile Leu Leu Phe Ser Gly Leu Ile Thr Gly Phe 
1               5                   10                  15      


Arg Ser Asp Ser Ser Ser Ser Leu Pro Pro Lys Leu Leu Leu Val Ser 
            20                  25                  30          


Phe Asp Gly Phe Arg Ala Asp Tyr Leu Lys Asn Tyr Glu Phe Pro His 
        35                  40                  45              


Leu Gln Asn Phe Ile Lys Glu Gly Val Leu Val Glu His Val Lys Asn 
    50                  55                  60                  


Val Phe Ile Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly 
65                  70                  75                  80  


Leu Tyr Glu Glu Ser His Gly Ile Val Ala Asn Ser Met Tyr Asp Ala 
                85                  90                  95      


Val Thr Lys Lys His Phe Ser Asp Ser Asn Asp Lys Asp Pro Phe Trp 
            100                 105                 110         


Trp Asn Glu Ala Val Pro Ile Trp Val Thr Asn Gln Leu Gln Glu Asn 
        115                 120                 125             


Arg Ser Ser Ala Ala Ala Met Trp Pro Gly Thr Asp Val Pro Ile His 
    130                 135                 140                 


Asp Thr Ile Ser Ser Tyr Phe Met Asn Tyr Asn Ser Ser Val Ser Phe 
145                 150                 155                 160 


Glu Glu Arg Leu Asn Asn Ile Thr Met Trp Leu Asn Asn Ser Asn Pro 
                165                 170                 175     


Pro Val Thr Phe Ala Thr Leu Tyr Trp Glu Glu Pro Asp Ala Ser Gly 
            180                 185                 190         


His Lys Tyr Gly Pro Glu Asp Lys Glu Asn Met Ser Arg Val Leu Lys 
        195                 200                 205             


Lys Ile Asp Asp Leu Ile Gly Asp Leu Val Gln Arg Leu Lys Met Leu 
    210                 215                 220                 


Gly Leu Trp Glu Asn Leu Asn Val Ile Ile Thr Ser Asp His Gly Met 
225                 230                 235                 240 


Thr Gln Cys Ser Gln Asp Arg Leu Ile Asn Leu Asp Ser Cys Ile Asp 
                245                 250                 255     


His Ser Tyr Tyr Thr Leu Ile Asp Leu Ser Pro Val Ala Ala Ile Leu 
            260                 265                 270         


Pro Lys Ile Asn Arg Thr Glu Val Tyr Asn Lys Leu Lys Asn Cys Ser 
        275                 280                 285             


Pro His Met Asn Val Tyr Leu Lys Glu Asp Ile Pro Asn Arg Phe Tyr 
    290                 295                 300                 


Tyr Gln His Asn Asp Arg Ile Gln Pro Ile Ile Leu Val Ala Asp Glu 
305                 310                 315                 320 


Gly Trp Thr Ile Val Leu Asn Glu Ser Ser Gln Lys Leu Gly Asp His 
                325                 330                 335     


Gly Tyr Asp Asn Ser Leu Pro Ser Met His Pro Phe Leu Ala Ala His 
            340                 345                 350         


Gly Pro Ala Phe His Lys Gly Tyr Lys His Ser Thr Ile Asn Ile Val 
        355                 360                 365             


Asp Ile Tyr Pro Met Met Cys His Ile Leu Gly Leu Lys Pro His Pro 
    370                 375                 380                 


Asn Asn Gly Thr Phe Gly His Thr Lys Cys Leu Leu Val Asp Gln Trp 
385                 390                 395                 400 


Cys Ile Asn Leu Pro Glu Ala Ile Ala Ile Val Ile Gly Ser Leu Leu 
                405                 410                 415     


Val Leu Thr Met Leu Thr Cys Leu Ile Ile Ile Met Gln Asn Arg Leu 
            420                 425                 430         


Ser Val Pro Arg Pro Phe Ser Arg Leu Gln Leu Gln Glu Asp Asp Asp 
        435                 440                 445             


Asp Pro Leu Ile Gly 
    450             


<210>  12
<211>  850
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP51 Amino Acid Sequence


<220>
<221>  SIGNAL
<222>  (24)..(25)
<223>  Cleavage point of the signal sequence

<220>
<221>  SIGNAL
<222>  (24)..(25)
<223>  Cleavage point of the signal peptide sequence

<400>  12

Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser Leu Gln Pro Ser Cys Ala Lys Glu Val Lys 
            20                  25                  30          


Ser Cys Lys Gly Arg Cys Phe Glu Arg Thr Phe Ser Asn Cys Arg Cys 
        35                  40                  45              


Asp Ala Ala Cys Val Ser Leu Gly Asn Cys Cys Leu Asp Phe Gln Glu 
    50                  55                  60                  


Thr Cys Val Glu Pro Thr His Ile Trp Thr Cys Asn Lys Phe Arg Cys 
65                  70                  75                  80  


Gly Glu Lys Arg Leu Ser Arg Phe Val Cys Ser Cys Ala Asp Asp Cys 
                85                  90                  95      


Lys Thr His Asn Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Asp 
            100                 105                 110         


Lys Lys Ser Trp Val Glu Glu Thr Cys Glu Ser Ile Asp Thr Pro Glu 
        115                 120                 125             


Cys Pro Ala Glu Phe Glu Ser Pro Pro Thr Leu Leu Phe Ser Leu Asp 
    130                 135                 140                 


Gly Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val 
145                 150                 155                 160 


Ile Ser Lys Leu Lys Asn Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro 
                165                 170                 175     


Met Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly 
            180                 185                 190         


Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro 
        195                 200                 205             


Lys Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro 
    210                 215                 220                 


Leu Trp Tyr Lys Gly Gln Pro Ile Trp Val Thr Ala Asn His Gln Glu 
225                 230                 235                 240 


Val Lys Ser Gly Thr Tyr Phe Trp Pro Gly Ser Asp Val Glu Ile Asp 
                245                 250                 255     


Gly Ile Leu Pro Asp Ile Tyr Lys Val Tyr Asn Gly Ser Val Pro Phe 
            260                 265                 270         


Glu Glu Arg Ile Leu Ala Val Leu Glu Trp Leu Gln Leu Pro Ser His 
        275                 280                 285             


Glu Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser 
    290                 295                 300                 


Gly His Ser His Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln 
305                 310                 315                 320 


Lys Val Asp Arg Leu Val Gly Met Leu Met Asp Gly Leu Lys Asp Leu 
                325                 330                 335     


Gly Leu Asp Lys Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met 
            340                 345                 350         


Glu Gln Gly Ser Cys Lys Lys Tyr Val Tyr Leu Asn Lys Tyr Leu Gly 
        355                 360                 365             


Asp Val Asn Asn Val Lys Val Val Tyr Gly Pro Ala Ala Arg Leu Arg 
    370                 375                 380                 


Pro Thr Asp Val Pro Glu Thr Tyr Tyr Ser Phe Asn Tyr Glu Ala Leu 
385                 390                 395                 400 


Ala Lys Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Arg Pro Tyr 
                405                 410                 415     


Leu Lys Pro Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg 
            420                 425                 430         


Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu 
        435                 440                 445             


Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp 
    450                 455                 460                 


Asn Leu Phe Ser Asn Met Gln Ala Leu Phe Ile Gly Tyr Gly Pro Ala 
465                 470                 475                 480 


Phe Lys His Gly Ala Glu Val Asp Ser Phe Glu Asn Ile Glu Val Tyr 
                485                 490                 495     


Asn Leu Met Cys Asp Leu Leu Gly Leu Ile Pro Ala Pro Asn Asn Gly 
            500                 505                 510         


Ser His Gly Ser Leu Asn His Leu Leu Lys Lys Pro Ile Tyr Asn Pro 
        515                 520                 525             


Ser His Pro Lys Glu Glu Gly Phe Leu Ser Gln Cys Pro Ile Lys Ser 
    530                 535                 540                 


Thr Ser Asn Asp Leu Gly Cys Thr Cys Asp Pro Trp Ile Val Pro Ile 
545                 550                 555                 560 


Lys Asp Phe Glu Lys Gln Leu Asn Leu Thr Thr Glu Asp Val Asp Asp 
                565                 570                 575     


Ile Tyr His Met Thr Val Pro Tyr Gly Arg Pro Arg Ile Leu Leu Lys 
            580                 585                 590         


Gln His Arg Val Cys Leu Leu Gln Gln Gln Gln Phe Leu Thr Gly Tyr 
        595                 600                 605             


Ser Leu Asp Leu Leu Met Pro Leu Trp Ala Ser Tyr Thr Phe Leu Ser 
    610                 615                 620                 


Asn Asp Gln Phe Ser Arg Asp Asp Phe Ser Asn Cys Leu Tyr Gln Asp 
625                 630                 635                 640 


Leu Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Tyr Tyr Lys Ser 
                645                 650                 655     


Asn Ser Lys Leu Ser Tyr Gly Phe Leu Thr Pro Pro Arg Leu Asn Arg 
            660                 665                 670         


Val Ser Asn His Ile Tyr Ser Glu Ala Leu Leu Thr Ser Asn Ile Val 
        675                 680                 685             


Pro Met Tyr Gln Ser Phe Gln Val Ile Trp His Tyr Leu His Asp Thr 
    690                 695                 700                 


Leu Leu Gln Arg Tyr Ala His Glu Arg Asn Gly Ile Asn Val Val Ser 
705                 710                 715                 720 


Gly Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Tyr Asp Ser Leu Glu 
                725                 730                 735     


Ile Leu Lys Gln Asn Ser Arg Val Ile Arg Ser Gln Glu Ile Leu Ile 
            740                 745                 750         


Pro Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Gln Leu Ser Glu 
        755                 760                 765             


Thr Pro Leu Glu Cys Ser Ala Leu Glu Ser Ser Ala Tyr Ile Leu Pro 
    770                 775                 780                 


His Arg Pro Asp Asn Ile Glu Ser Cys Thr His Gly Lys Arg Glu Ser 
785                 790                 795                 800 


Ser Trp Val Glu Glu Leu Leu Thr Leu His Arg Ala Arg Val Thr Asp 
                805                 810                 815     


Val Glu Leu Ile Thr Gly Leu Ser Phe Tyr Gln Asp Arg Gln Glu Ser 
            820                 825                 830         


Val Ser Glu Leu Leu Arg Leu Lys Thr His Leu Pro Ile Phe Ser Gln 
        835                 840                 845             


Glu Asp 
    850 


<210>  13
<211>  1474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP51  - ALB Amino Acid Sequence


<220>
<221>  SIGNAL
<222>  (24)..(25)
<223>  Cleavage point of the signal sequence

<220>
<221>  SIGNAL
<222>  (24)..(25)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (857)..(1474)
<223>  Indicate Albumin sequence

<400>  13

Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser Leu Gln Pro Ser Cys Ala Lys Glu Val Lys 
            20                  25                  30          


Ser Cys Lys Gly Arg Cys Phe Glu Arg Thr Phe Ser Asn Cys Arg Cys 
        35                  40                  45              


Asp Ala Ala Cys Val Ser Leu Gly Asn Cys Cys Leu Asp Phe Gln Glu 
    50                  55                  60                  


Thr Cys Val Glu Pro Thr His Ile Trp Thr Cys Asn Lys Phe Arg Cys 
65                  70                  75                  80  


Gly Glu Lys Arg Leu Ser Arg Phe Val Cys Ser Cys Ala Asp Asp Cys 
                85                  90                  95      


Lys Thr His Asn Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Asp 
            100                 105                 110         


Lys Lys Ser Trp Val Glu Glu Thr Cys Glu Ser Ile Asp Thr Pro Glu 
        115                 120                 125             


Cys Pro Ala Glu Phe Glu Ser Pro Pro Thr Leu Leu Phe Ser Leu Asp 
    130                 135                 140                 


Gly Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val 
145                 150                 155                 160 


Ile Ser Lys Leu Lys Asn Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro 
                165                 170                 175     


Met Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly 
            180                 185                 190         


Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro 
        195                 200                 205             


Lys Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro 
    210                 215                 220                 


Leu Trp Tyr Lys Gly Gln Pro Ile Trp Val Thr Ala Asn His Gln Glu 
225                 230                 235                 240 


Val Lys Ser Gly Thr Tyr Phe Trp Pro Gly Ser Asp Val Glu Ile Asp 
                245                 250                 255     


Gly Ile Leu Pro Asp Ile Tyr Lys Val Tyr Asn Gly Ser Val Pro Phe 
            260                 265                 270         


Glu Glu Arg Ile Leu Ala Val Leu Glu Trp Leu Gln Leu Pro Ser His 
        275                 280                 285             


Glu Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser 
    290                 295                 300                 


Gly His Ser His Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln 
305                 310                 315                 320 


Lys Val Asp Arg Leu Val Gly Met Leu Met Asp Gly Leu Lys Asp Leu 
                325                 330                 335     


Gly Leu Asp Lys Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met 
            340                 345                 350         


Glu Gln Gly Ser Cys Lys Lys Tyr Val Tyr Leu Asn Lys Tyr Leu Gly 
        355                 360                 365             


Asp Val Asn Asn Val Lys Val Val Tyr Gly Pro Ala Ala Arg Leu Arg 
    370                 375                 380                 


Pro Thr Asp Val Pro Glu Thr Tyr Tyr Ser Phe Asn Tyr Glu Ala Leu 
385                 390                 395                 400 


Ala Lys Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Arg Pro Tyr 
                405                 410                 415     


Leu Lys Pro Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg 
            420                 425                 430         


Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu 
        435                 440                 445             


Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp 
    450                 455                 460                 


Asn Leu Phe Ser Asn Met Gln Ala Leu Phe Ile Gly Tyr Gly Pro Ala 
465                 470                 475                 480 


Phe Lys His Gly Ala Glu Val Asp Ser Phe Glu Asn Ile Glu Val Tyr 
                485                 490                 495     


Asn Leu Met Cys Asp Leu Leu Gly Leu Ile Pro Ala Pro Asn Asn Gly 
            500                 505                 510         


Ser His Gly Ser Leu Asn His Leu Leu Lys Lys Pro Ile Tyr Asn Pro 
        515                 520                 525             


Ser His Pro Lys Glu Glu Gly Phe Leu Ser Gln Cys Pro Ile Lys Ser 
    530                 535                 540                 


Thr Ser Asn Asp Leu Gly Cys Thr Cys Asp Pro Trp Ile Val Pro Ile 
545                 550                 555                 560 


Lys Asp Phe Glu Lys Gln Leu Asn Leu Thr Thr Glu Asp Val Asp Asp 
                565                 570                 575     


Ile Tyr His Met Thr Val Pro Tyr Gly Arg Pro Arg Ile Leu Leu Lys 
            580                 585                 590         


Gln His Arg Val Cys Leu Leu Gln Gln Gln Gln Phe Leu Thr Gly Tyr 
        595                 600                 605             


Ser Leu Asp Leu Leu Met Pro Leu Trp Ala Ser Tyr Thr Phe Leu Ser 
    610                 615                 620                 


Asn Asp Gln Phe Ser Arg Asp Asp Phe Ser Asn Cys Leu Tyr Gln Asp 
625                 630                 635                 640 


Leu Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Tyr Tyr Lys Ser 
                645                 650                 655     


Asn Ser Lys Leu Ser Tyr Gly Phe Leu Thr Pro Pro Arg Leu Asn Arg 
            660                 665                 670         


Val Ser Asn His Ile Tyr Ser Glu Ala Leu Leu Thr Ser Asn Ile Val 
        675                 680                 685             


Pro Met Tyr Gln Ser Phe Gln Val Ile Trp His Tyr Leu His Asp Thr 
    690                 695                 700                 


Leu Leu Gln Arg Tyr Ala His Glu Arg Asn Gly Ile Asn Val Val Ser 
705                 710                 715                 720 


Gly Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Tyr Asp Ser Leu Glu 
                725                 730                 735     


Ile Leu Lys Gln Asn Ser Arg Val Ile Arg Ser Gln Glu Ile Leu Ile 
            740                 745                 750         


Pro Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Gln Leu Ser Glu 
        755                 760                 765             


Thr Pro Leu Glu Cys Ser Ala Leu Glu Ser Ser Ala Tyr Ile Leu Pro 
    770                 775                 780                 


His Arg Pro Asp Asn Ile Glu Ser Cys Thr His Gly Lys Arg Glu Ser 
785                 790                 795                 800 


Ser Trp Val Glu Glu Leu Leu Thr Leu His Arg Ala Arg Val Thr Asp 
                805                 810                 815     


Val Glu Leu Ile Thr Gly Leu Ser Phe Tyr Gln Asp Arg Gln Glu Ser 
            820                 825                 830         


Val Ser Glu Leu Leu Arg Leu Lys Thr His Leu Pro Ile Phe Ser Gln 
        835                 840                 845             


Glu Asp Gly Gly Ser Gly Gly Ser Met Lys Trp Val Thr Phe Leu Leu 
    850                 855                 860                 


Leu Leu Phe Val Ser Gly Ser Ala Phe Ser Arg Gly Val Phe Arg Arg 
865                 870                 875                 880 


Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu 
                885                 890                 895     


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            900                 905                 910         


Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        915                 920                 925             


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    930                 935                 940                 


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
945                 950                 955                 960 


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                965                 970                 975     


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            980                 985                 990         


Pro Pro Phe Glu Arg Pro Glu Ala  Glu Ala Met Cys Thr  Ser Phe Lys 
        995                 1000                 1005             


Glu Asn  Pro Thr Thr Phe Met  Gly His Tyr Leu His  Glu Val Ala 
    1010                 1015                 1020             


Arg Arg  His Pro Tyr Phe Tyr  Ala Pro Glu Leu Leu  Tyr Tyr Ala 
    1025                 1030                 1035             


Glu Gln  Tyr Asn Glu Ile Leu  Thr Gln Cys Cys Ala  Glu Ala Asp 
    1040                 1045                 1050             


Lys Glu  Ser Cys Leu Thr Pro  Lys Leu Asp Gly Val  Lys Glu Lys 
    1055                 1060                 1065             


Ala Leu  Val Ser Ser Val Arg  Gln Arg Met Lys Cys  Ser Ser Met 
    1070                 1075                 1080             


Gln Lys  Phe Gly Glu Arg Ala  Phe Lys Ala Trp Ala  Val Ala Arg 
    1085                 1090                 1095             


Leu Ser  Gln Thr Phe Pro Asn  Ala Asp Phe Ala Glu  Ile Thr Lys 
    1100                 1105                 1110             


Leu Ala  Thr Asp Leu Thr Lys  Val Asn Lys Glu Cys  Cys His Gly 
    1115                 1120                 1125             


Asp Leu  Leu Glu Cys Ala Asp  Asp Arg Ala Glu Leu  Ala Lys Tyr 
    1130                 1135                 1140             


Met Cys  Glu Asn Gln Ala Thr  Ile Ser Ser Lys Leu  Gln Thr Cys 
    1145                 1150                 1155             


Cys Asp  Lys Pro Leu Leu Lys  Lys Ala His Cys Leu  Ser Glu Val 
    1160                 1165                 1170             


Glu His  Asp Thr Met Pro Ala  Asp Leu Pro Ala Ile  Ala Ala Asp 
    1175                 1180                 1185             


Phe Val  Glu Asp Gln Glu Val  Cys Lys Asn Tyr Ala  Glu Ala Lys 
    1190                 1195                 1200             


Asp Val  Phe Leu Gly Thr Phe  Leu Tyr Glu Tyr Ser  Arg Arg His 
    1205                 1210                 1215             


Pro Asp  Tyr Ser Val Ser Leu  Leu Leu Arg Leu Ala  Lys Lys Tyr 
    1220                 1225                 1230             


Glu Ala  Thr Leu Glu Lys Cys  Cys Ala Glu Ala Asn  Pro Pro Ala 
    1235                 1240                 1245             


Cys Tyr  Gly Thr Val Leu Ala  Glu Phe Gln Pro Leu  Val Glu Glu 
    1250                 1255                 1260             


Pro Lys  Asn Leu Val Lys Thr  Asn Cys Asp Leu Tyr  Glu Lys Leu 
    1265                 1270                 1275             


Gly Glu  Tyr Gly Phe Gln Asn  Ala Ile Leu Val Arg  Tyr Thr Gln 
    1280                 1285                 1290             


Lys Ala  Pro Gln Val Ser Thr  Pro Thr Leu Val Glu  Ala Ala Arg 
    1295                 1300                 1305             


Asn Leu  Gly Arg Val Gly Thr  Lys Cys Cys Thr Leu  Pro Glu Asp 
    1310                 1315                 1320             


Gln Arg  Leu Pro Cys Val Glu  Asp Tyr Leu Ser Ala  Ile Leu Asn 
    1325                 1330                 1335             


Arg Val  Cys Leu Leu His Glu  Lys Thr Pro Val Ser  Glu His Val 
    1340                 1345                 1350             


Thr Lys  Cys Cys Ser Gly Ser  Leu Val Glu Arg Arg  Pro Cys Phe 
    1355                 1360                 1365             


Ser Ala  Leu Thr Val Asp Glu  Thr Tyr Val Pro Lys  Glu Phe Lys 
    1370                 1375                 1380             


Ala Glu  Thr Phe Thr Phe His  Ser Asp Ile Cys Thr  Leu Pro Glu 
    1385                 1390                 1395             


Lys Glu  Lys Gln Ile Lys Lys  Gln Thr Ala Leu Ala  Glu Leu Val 
    1400                 1405                 1410             


Lys His  Lys Pro Lys Ala Thr  Ala Glu Gln Leu Lys  Thr Val Met 
    1415                 1420                 1425             


Asp Asp  Phe Ala Gln Phe Leu  Asp Thr Cys Cys Lys  Ala Ala Asp 
    1430                 1435                 1440             


Lys Asp  Thr Cys Phe Ser Thr  Glu Gly Pro Asn Leu  Val Thr Arg 
    1445                 1450                 1455             


Cys Lys  Asp Ala Leu Ala Arg  Ser Trp Ser His Pro  Gln Phe Glu 
    1460                 1465                 1470             


Lys 
    


<210>  14
<211>  1074
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP5-NPP3-Fc sequence


<220>
<221>  SIGNAL
<222>  (22)..(23)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (848)..(1074)

<400>  14

Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe 
            20                  25                  30          


Asp Ala Ser Phe Arg Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys 
        35                  40                  45              


Lys Asp Arg Gly Asp Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu 
    50                  55                  60                  


Ser Thr Arg Ile Trp Met Cys Asn Lys Phe Arg Cys Gly Glu Arg Leu 
65                  70                  75                  80  


Glu Ala Ser Leu Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp 
                85                  90                  95      


Cys Cys Ala Asp Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu 
            100                 105                 110         


Glu Glu Asn Cys Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe 
        115                 120                 125             


Asp Leu Pro Pro Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu 
    130                 135                 140                 


Tyr Leu Tyr Thr Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys 
145                 150                 155                 160 


Thr Cys Gly Ile His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys 
                165                 170                 175     


Thr Phe Pro Asn His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser 
            180                 185                 190         


His Gly Ile Ile Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn 
        195                 200                 205             


Phe Ser Leu Ser Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly 
    210                 215                 220                 


Gln Pro Met Trp Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr 
225                 230                 235                 240 


Tyr Phe Trp Pro Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser 
                245                 250                 255     


Ile Tyr Met Pro Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser 
            260                 265                 270         


Thr Leu Leu Lys Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe 
        275                 280                 285             


Tyr Thr Met Tyr Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly 
    290                 295                 300                 


Pro Val Ser Ala Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala 
305                 310                 315                 320 


Phe Gly Met Leu Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys 
                325                 330                 335     


Val Asn Ile Ile Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys 
            340                 345                 350         


Asn Lys Met Glu Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe 
        355                 360                 365             


Tyr Met Tyr Glu Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro 
    370                 375                 380                 


His Asp Phe Phe Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser 
385                 390                 395                 400 


Cys Arg Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu 
                405                 410                 415     


Pro Lys Arg Leu His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His 
            420                 425                 430         


Leu Phe Val Asp Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr 
        435                 440                 445             


Asn Cys Gly Gly Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met 
    450                 455                 460                 


Glu Ala Ile Phe Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu 
465                 470                 475                 480 


Val Glu Pro Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                485                 490                 495     


Leu Arg Ile Gln Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            500                 505                 510         


His Leu Leu Lys Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val 
        515                 520                 525             


Ser Lys Phe Ser Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser 
    530                 535                 540                 


Leu Asp Cys Phe Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln 
545                 550                 555                 560 


Val Asn Gln Met Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val 
                565                 570                 575     


Lys Val Asn Leu Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val 
            580                 585                 590         


Asp His Cys Leu Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys 
        595                 600                 605             


Ala Met Arg Met Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly 
    610                 615                 620                 


Asp Thr Ser Pro Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp 
625                 630                 635                 640 


Val Arg Val Pro Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala 
                645                 650                 655     


Asp Lys Asn Ile Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg 
            660                 665                 670         


Thr Ser Asp Ser Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro 
        675                 680                 685             


Met Tyr Glu Glu Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu 
    690                 695                 700                 


Leu Ile Lys His Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly 
705                 710                 715                 720 


Pro Ile Phe Asp Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu 
                725                 730                 735     


Ile Thr Lys His Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr 
            740                 745                 750         


Phe Val Val Leu Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn 
        755                 760                 765             


Cys Pro Gly Trp Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro 
    770                 775                 780                 


Thr Asn Val Glu Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val 
785                 790                 795                 800 


Glu Glu Arg Phe Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu 
                805                 810                 815     


Leu Thr Gly Leu Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu 
            820                 825                 830         


Ile Leu Gln Leu Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile Asp 
        835                 840                 845             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    850                 855                 860                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
865                 870                 875                 880 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                885                 890                 895     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            900                 905                 910         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        915                 920                 925             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    930                 935                 940                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
945                 950                 955                 960 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                965                 970                 975     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            980                 985                 990         


Thr Cys Leu Val Lys Gly Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp 
        995                 1000                 1005             


Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro 
    1010                 1015                 1020             


Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr 
    1025                 1030                 1035             


Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser 
    1040                 1045                 1050             


Val Met  His Glu Ala Leu His  Asn His Tyr Thr Gln  Lys Ser Leu 
    1055                 1060                 1065             


Ser Leu  Ser Pro Gly Lys 
    1070                 


<210>  15
<211>  1469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP5-NPP3-Albumin sequence


<220>
<221>  SIGNAL
<222>  (22)..(23)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (848)..(1469)

<400>  15

Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe 
            20                  25                  30          


Asp Ala Ser Phe Arg Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys 
        35                  40                  45              


Lys Asp Arg Gly Asp Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu 
    50                  55                  60                  


Ser Thr Arg Ile Trp Met Cys Asn Lys Phe Arg Cys Gly Glu Arg Leu 
65                  70                  75                  80  


Glu Ala Ser Leu Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp 
                85                  90                  95      


Cys Cys Ala Asp Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu 
            100                 105                 110         


Glu Glu Asn Cys Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe 
        115                 120                 125             


Asp Leu Pro Pro Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu 
    130                 135                 140                 


Tyr Leu Tyr Thr Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys 
145                 150                 155                 160 


Thr Cys Gly Ile His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys 
                165                 170                 175     


Thr Phe Pro Asn His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser 
            180                 185                 190         


His Gly Ile Ile Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn 
        195                 200                 205             


Phe Ser Leu Ser Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly 
    210                 215                 220                 


Gln Pro Met Trp Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr 
225                 230                 235                 240 


Tyr Phe Trp Pro Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser 
                245                 250                 255     


Ile Tyr Met Pro Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser 
            260                 265                 270         


Thr Leu Leu Lys Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe 
        275                 280                 285             


Tyr Thr Met Tyr Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly 
    290                 295                 300                 


Pro Val Ser Ala Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala 
305                 310                 315                 320 


Phe Gly Met Leu Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys 
                325                 330                 335     


Val Asn Ile Ile Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys 
            340                 345                 350         


Asn Lys Met Glu Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe 
        355                 360                 365             


Tyr Met Tyr Glu Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro 
    370                 375                 380                 


His Asp Phe Phe Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser 
385                 390                 395                 400 


Cys Arg Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu 
                405                 410                 415     


Pro Lys Arg Leu His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His 
            420                 425                 430         


Leu Phe Val Asp Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr 
        435                 440                 445             


Asn Cys Gly Gly Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met 
    450                 455                 460                 


Glu Ala Ile Phe Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu 
465                 470                 475                 480 


Val Glu Pro Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                485                 490                 495     


Leu Arg Ile Gln Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            500                 505                 510         


His Leu Leu Lys Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val 
        515                 520                 525             


Ser Lys Phe Ser Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser 
    530                 535                 540                 


Leu Asp Cys Phe Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln 
545                 550                 555                 560 


Val Asn Gln Met Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val 
                565                 570                 575     


Lys Val Asn Leu Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val 
            580                 585                 590         


Asp His Cys Leu Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys 
        595                 600                 605             


Ala Met Arg Met Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly 
    610                 615                 620                 


Asp Thr Ser Pro Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp 
625                 630                 635                 640 


Val Arg Val Pro Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala 
                645                 650                 655     


Asp Lys Asn Ile Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg 
            660                 665                 670         


Thr Ser Asp Ser Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro 
        675                 680                 685             


Met Tyr Glu Glu Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu 
    690                 695                 700                 


Leu Ile Lys His Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly 
705                 710                 715                 720 


Pro Ile Phe Asp Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu 
                725                 730                 735     


Ile Thr Lys His Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr 
            740                 745                 750         


Phe Val Val Leu Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn 
        755                 760                 765             


Cys Pro Gly Trp Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro 
    770                 775                 780                 


Thr Asn Val Glu Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val 
785                 790                 795                 800 


Glu Glu Arg Phe Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu 
                805                 810                 815     


Leu Thr Gly Leu Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu 
            820                 825                 830         


Ile Leu Gln Leu Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile Gly 
        835                 840                 845             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Lys Trp 
    850                 855                 860                 


Val Thr Phe Leu Leu Leu Leu Phe Val Ser Gly Ser Ala Phe Ser Arg 
865                 870                 875                 880 


Gly Val Phe Arg Arg Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr 
                885                 890                 895     


Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe 
            900                 905                 910         


Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val 
        915                 920                 925             


Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
    930                 935                 940                 


Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
945                 950                 955                 960 


Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys 
                965                 970                 975     


Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
            980                 985                 990         


Asp Asn Pro Ser Leu Pro Pro Phe  Glu Arg Pro Glu Ala  Glu Ala Met 
        995                 1000                 1005             


Cys Thr  Ser Phe Lys Glu Asn  Pro Thr Thr Phe Met  Gly His Tyr 
    1010                 1015                 1020             


Leu His  Glu Val Ala Arg Arg  His Pro Tyr Phe Tyr  Ala Pro Glu 
    1025                 1030                 1035             


Leu Leu  Tyr Tyr Ala Glu Gln  Tyr Asn Glu Ile Leu  Thr Gln Cys 
    1040                 1045                 1050             


Cys Ala  Glu Ala Asp Lys Glu  Ser Cys Leu Thr Pro  Lys Leu Asp 
    1055                 1060                 1065             


Gly Val  Lys Glu Lys Ala Leu  Val Ser Ser Val Arg  Gln Arg Met 
    1070                 1075                 1080             


Lys Cys  Ser Ser Met Gln Lys  Phe Gly Glu Arg Ala  Phe Lys Ala 
    1085                 1090                 1095             


Trp Ala  Val Ala Arg Leu Ser  Gln Thr Phe Pro Asn  Ala Asp Phe 
    1100                 1105                 1110             


Ala Glu  Ile Thr Lys Leu Ala  Thr Asp Leu Thr Lys  Val Asn Lys 
    1115                 1120                 1125             


Glu Cys  Cys His Gly Asp Leu  Leu Glu Cys Ala Asp  Asp Arg Ala 
    1130                 1135                 1140             


Glu Leu  Ala Lys Tyr Met Cys  Glu Asn Gln Ala Thr  Ile Ser Ser 
    1145                 1150                 1155             


Lys Leu  Gln Thr Cys Cys Asp  Lys Pro Leu Leu Lys  Lys Ala His 
    1160                 1165                 1170             


Cys Leu  Ser Glu Val Glu His  Asp Thr Met Pro Ala  Asp Leu Pro 
    1175                 1180                 1185             


Ala Ile  Ala Ala Asp Phe Val  Glu Asp Gln Glu Val  Cys Lys Asn 
    1190                 1195                 1200             


Tyr Ala  Glu Ala Lys Asp Val  Phe Leu Gly Thr Phe  Leu Tyr Glu 
    1205                 1210                 1215             


Tyr Ser  Arg Arg His Pro Asp  Tyr Ser Val Ser Leu  Leu Leu Arg 
    1220                 1225                 1230             


Leu Ala  Lys Lys Tyr Glu Ala  Thr Leu Glu Lys Cys  Cys Ala Glu 
    1235                 1240                 1245             


Ala Asn  Pro Pro Ala Cys Tyr  Gly Thr Val Leu Ala  Glu Phe Gln 
    1250                 1255                 1260             


Pro Leu  Val Glu Glu Pro Lys  Asn Leu Val Lys Thr  Asn Cys Asp 
    1265                 1270                 1275             


Leu Tyr  Glu Lys Leu Gly Glu  Tyr Gly Phe Gln Asn  Ala Ile Leu 
    1280                 1285                 1290             


Val Arg  Tyr Thr Gln Lys Ala  Pro Gln Val Ser Thr  Pro Thr Leu 
    1295                 1300                 1305             


Val Glu  Ala Ala Arg Asn Leu  Gly Arg Val Gly Thr  Lys Cys Cys 
    1310                 1315                 1320             


Thr Leu  Pro Glu Asp Gln Arg  Leu Pro Cys Val Glu  Asp Tyr Leu 
    1325                 1330                 1335             


Ser Ala  Ile Leu Asn Arg Val  Cys Leu Leu His Glu  Lys Thr Pro 
    1340                 1345                 1350             


Val Ser  Glu His Val Thr Lys  Cys Cys Ser Gly Ser  Leu Val Glu 
    1355                 1360                 1365             


Arg Arg  Pro Cys Phe Ser Ala  Leu Thr Val Asp Glu  Thr Tyr Val 
    1370                 1375                 1380             


Pro Lys  Glu Phe Lys Ala Glu  Thr Phe Thr Phe His  Ser Asp Ile 
    1385                 1390                 1395             


Cys Thr  Leu Pro Glu Lys Glu  Lys Gln Ile Lys Lys  Gln Thr Ala 
    1400                 1405                 1410             


Leu Ala  Glu Leu Val Lys His  Lys Pro Lys Ala Thr  Ala Glu Gln 
    1415                 1420                 1425             


Leu Lys  Thr Val Met Asp Asp  Phe Ala Gln Phe Leu  Asp Thr Cys 
    1430                 1435                 1440             


Cys Lys  Ala Ala Asp Lys Asp  Thr Cys Phe Ser Thr  Glu Gly Pro 
    1445                 1450                 1455             


Asn Leu  Val Thr Arg Cys Lys  Asp Ala Leu Ala 
    1460                 1465                 


<210>  16
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP5 Protein Export Signal Sequence


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  X can be any amino acid

<400>  16

Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser Xaa 
            20              


<210>  17
<211>  1079
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP51-Fc


<220>
<221>  SIGNAL
<222>  (22)..(23)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (853)..(1079)
<223>  Indicate Fc sequence

<400>  17

Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser Gly Leu Lys Pro Ser Cys Ala Lys Glu Val 
            20                  25                  30          


Lys Ser Cys Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg 
        35                  40                  45              


Cys Asp Ala Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln 
    50                  55                  60                  


Glu Thr Cys Ile Glu Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg 
65                  70                  75                  80  


Cys Gly Glu Lys Arg Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp 
                85                  90                  95      


Cys Lys Asp Lys Gly Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln 
            100                 105                 110         


Gly Glu Lys Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro 
        115                 120                 125             


Gln Cys Pro Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu 
    130                 135                 140                 


Asp Gly Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro 
145                 150                 155                 160 


Val Ile Ser Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg 
                165                 170                 175     


Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr 
            180                 185                 190         


Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp 
        195                 200                 205             


Pro Lys Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn 
    210                 215                 220                 


Pro Glu Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln 
225                 230                 235                 240 


Gly Leu Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile 
                245                 250                 255     


Asn Gly Ile Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro 
            260                 265                 270         


Phe Glu Glu Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys 
        275                 280                 285             


Asp Glu Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser 
    290                 295                 300                 


Ser Gly His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu 
305                 310                 315                 320 


Gln Arg Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu 
                325                 330                 335     


Leu Asn Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly 
            340                 345                 350         


Met Glu Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu 
        355                 360                 365             


Gly Asp Val Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu 
    370                 375                 380                 


Arg Pro Ser Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly 
385                 390                 395                 400 


Ile Ala Arg Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro 
                405                 410                 415     


Tyr Leu Lys His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp 
            420                 425                 430         


Arg Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala 
        435                 440                 445             


Leu Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser 
    450                 455                 460                 


Asp Asn Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro 
465                 470                 475                 480 


Gly Phe Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val 
                485                 490                 495     


Tyr Asn Leu Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn 
            500                 505                 510         


Gly Thr His Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr 
        515                 520                 525             


Pro Lys His Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr 
    530                 535                 540                 


Arg Asn Pro Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu 
545                 550                 555                 560 


Pro Ile Glu Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu 
                565                 570                 575     


Lys Ile Ile Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu 
            580                 585                 590         


Gln Lys Glu Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser 
        595                 600                 605             


Gly Tyr Ser Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val 
    610                 615                 620                 


Asp Arg Asn Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr 
625                 630                 635                 640 


Gln Asp Phe Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr 
                645                 650                 655     


Lys Asn Asn Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu 
            660                 665                 670         


Asn Lys Asn Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn 
        675                 680                 685             


Ile Val Pro Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His 
    690                 695                 700                 


Asp Thr Leu Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val 
705                 710                 715                 720 


Val Ser Gly Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser 
                725                 730                 735     


Leu Glu Asn Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile 
            740                 745                 750         


Leu Ile Pro Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr 
        755                 760                 765             


Ser Gln Thr Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile 
    770                 775                 780                 


Leu Pro His Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His 
785                 790                 795                 800 


Asp Ser Ser Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile 
                805                 810                 815     


Thr Asp Val Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys 
            820                 825                 830         


Glu Pro Val Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe 
        835                 840                 845             


Ser Gln Glu Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    850                 855                 860                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
865                 870                 875                 880 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                885                 890                 895     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            900                 905                 910         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        915                 920                 925             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    930                 935                 940                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
945                 950                 955                 960 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                965                 970                 975     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            980                 985                 990         


Asn Gln Val Ser Leu Thr Cys Leu  Val Lys Gly Phe Tyr  Pro Ser Asp 
        995                 1000                 1005             


Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr 
    1010                 1015                 1020             


Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu 
    1025                 1030                 1035             


Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn 
    1040                 1045                 1050             


Val Phe  Ser Cys Ser Val Met  His Glu Ala Leu His  Asn His Tyr 
    1055                 1060                 1065             


Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly Lys 
    1070                 1075                 


<210>  18
<211>  1082
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP71-Fc Amino Acid Sequence


<220>
<221>  SIGNAL
<222>  (22)..(23)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (856)..(1082)
<223>  Indicate Fc sequence

<400>  18

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Ala Gly Leu Lys Pro Ser Cys Ala Lys Glu Val 
            20                  25                  30          


Lys Ser Cys Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg 
        35                  40                  45              


Cys Asp Ala Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln 
    50                  55                  60                  


Glu Thr Cys Ile Glu Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg 
65                  70                  75                  80  


Cys Gly Glu Lys Arg Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp 
                85                  90                  95      


Cys Lys Asp Lys Gly Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln 
            100                 105                 110         


Gly Glu Lys Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro 
        115                 120                 125             


Gln Cys Pro Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu 
    130                 135                 140                 


Asp Gly Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro 
145                 150                 155                 160 


Val Ile Ser Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg 
                165                 170                 175     


Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr 
            180                 185                 190         


Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp 
        195                 200                 205             


Pro Lys Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn 
    210                 215                 220                 


Pro Glu Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln 
225                 230                 235                 240 


Gly Leu Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile 
                245                 250                 255     


Asn Gly Ile Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro 
            260                 265                 270         


Phe Glu Glu Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys 
        275                 280                 285             


Asp Glu Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser 
    290                 295                 300                 


Ser Gly His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu 
305                 310                 315                 320 


Gln Arg Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu 
                325                 330                 335     


Leu Asn Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly 
            340                 345                 350         


Met Glu Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu 
        355                 360                 365             


Gly Asp Val Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu 
    370                 375                 380                 


Arg Pro Ser Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly 
385                 390                 395                 400 


Ile Ala Arg Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro 
                405                 410                 415     


Tyr Leu Lys His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp 
            420                 425                 430         


Arg Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala 
        435                 440                 445             


Leu Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser 
    450                 455                 460                 


Asp Asn Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro 
465                 470                 475                 480 


Gly Phe Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val 
                485                 490                 495     


Tyr Asn Leu Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn 
            500                 505                 510         


Gly Thr His Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr 
        515                 520                 525             


Pro Lys His Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr 
    530                 535                 540                 


Arg Asn Pro Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu 
545                 550                 555                 560 


Pro Ile Glu Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu 
                565                 570                 575     


Lys Ile Ile Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu 
            580                 585                 590         


Gln Lys Glu Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser 
        595                 600                 605             


Gly Tyr Ser Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val 
    610                 615                 620                 


Asp Arg Asn Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr 
625                 630                 635                 640 


Gln Asp Phe Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr 
                645                 650                 655     


Lys Asn Asn Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu 
            660                 665                 670         


Asn Lys Asn Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn 
        675                 680                 685             


Ile Val Pro Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His 
    690                 695                 700                 


Asp Thr Leu Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val 
705                 710                 715                 720 


Val Ser Gly Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser 
                725                 730                 735     


Leu Glu Asn Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile 
            740                 745                 750         


Leu Ile Pro Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr 
        755                 760                 765             


Ser Gln Thr Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile 
    770                 775                 780                 


Leu Pro His Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His 
785                 790                 795                 800 


Asp Ser Ser Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile 
                805                 810                 815     


Thr Asp Val Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys 
            820                 825                 830         


Glu Pro Val Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe 
        835                 840                 845             


Ser Gln Glu Asp Leu Ile Asn Asp Lys Thr His Thr Cys Pro Pro Cys 
    850                 855                 860                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
865                 870                 875                 880 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                885                 890                 895     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            900                 905                 910         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        915                 920                 925             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    930                 935                 940                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
945                 950                 955                 960 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                965                 970                 975     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            980                 985                 990         


Met Thr Lys Asn Gln Val Ser Leu  Thr Cys Leu Val Lys  Gly Phe Tyr 
        995                 1000                 1005             


Pro Ser  Asp Ile Ala Val Glu  Trp Glu Ser Asn Gly  Gln Pro Glu 
    1010                 1015                 1020             


Asn Asn  Tyr Lys Thr Thr Pro  Pro Val Leu Asp Ser  Asp Gly Ser 
    1025                 1030                 1035             


Phe Phe  Leu Tyr Ser Lys Leu  Thr Val Asp Lys Ser  Arg Trp Gln 
    1040                 1045                 1050             


Gln Gly  Asn Val Phe Ser Cys  Ser Val Met His Glu  Ala Leu His 
    1055                 1060                 1065             


Asn His  Tyr Thr Gln Lys Ser  Leu Ser Leu Ser Pro  Gly Lys 
    1070                 1075                 1080         


<210>  19
<211>  849
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP71 (lacking NPP1 N-Terminus GLK) Amino Acid Sequence


<220>
<221>  SIGNAL
<222>  (22)..(23)
<223>  Cleavage point of the signal peptide sequence

<400>  19

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Ala Pro Ser Cys Ala Lys Glu Val Lys Ser Cys 
            20                  25                  30          


Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala 
        35                  40                  45              


Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys 
    50                  55                  60                  


Ile Glu Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu 
65                  70                  75                  80  


Lys Arg Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp 
                85                  90                  95      


Lys Gly Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys 
            100                 105                 110         


Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro 
        115                 120                 125             


Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe 
    130                 135                 140                 


Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser 
145                 150                 155                 160 


Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr 
                165                 170                 175     


Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr 
            180                 185                 190         


Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met 
        195                 200                 205             


Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp 
    210                 215                 220                 


Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys 
225                 230                 235                 240 


Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile 
                245                 250                 255     


Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu 
            260                 265                 270         


Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg 
        275                 280                 285             


Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His 
    290                 295                 300                 


Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val 
305                 310                 315                 320 


Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu 
                325                 330                 335     


His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln 
            340                 345                 350         


Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val 
        355                 360                 365             


Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser 
    370                 375                 380                 


Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg 
385                 390                 395                 400 


Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys 
                405                 410                 415     


His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu 
            420                 425                 430         


Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro 
        435                 440                 445             


Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val 
    450                 455                 460                 


Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys 
465                 470                 475                 480 


His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu 
                485                 490                 495     


Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His 
            500                 505                 510         


Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His 
        515                 520                 525             


Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro 
    530                 535                 540                 


Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu 
545                 550                 555                 560 


Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile 
                565                 570                 575     


Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu 
            580                 585                 590         


Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser 
        595                 600                 605             


Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn 
    610                 615                 620                 


Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe 
625                 630                 635                 640 


Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn 
                645                 650                 655     


Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn 
            660                 665                 670         


Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro 
        675                 680                 685             


Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu 
    690                 695                 700                 


Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly 
705                 710                 715                 720 


Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn 
                725                 730                 735     


Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro 
            740                 745                 750         


Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr 
        755                 760                 765             


Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His 
    770                 775                 780                 


Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser 
785                 790                 795                 800 


Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val 
                805                 810                 815     


Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val 
            820                 825                 830         


Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu 
        835                 840                 845             


Asp 
    


<210>  20
<211>  1079
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP71 (lacking NPP1 N-Terminus GLK) - Fc Amino Acid Sequence


<220>
<221>  SIGNAL
<222>  (22)..(23)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (854)..(1079)
<223>  Indicate Fc sequence

<400>  20

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Ala Pro Ser Cys Ala Lys Glu Val Lys Ser Cys 
            20                  25                  30          


Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala 
        35                  40                  45              


Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys 
    50                  55                  60                  


Ile Glu Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu 
65                  70                  75                  80  


Lys Arg Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp 
                85                  90                  95      


Lys Gly Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys 
            100                 105                 110         


Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro 
        115                 120                 125             


Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe 
    130                 135                 140                 


Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser 
145                 150                 155                 160 


Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr 
                165                 170                 175     


Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr 
            180                 185                 190         


Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met 
        195                 200                 205             


Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp 
    210                 215                 220                 


Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys 
225                 230                 235                 240 


Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile 
                245                 250                 255     


Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu 
            260                 265                 270         


Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg 
        275                 280                 285             


Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His 
    290                 295                 300                 


Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val 
305                 310                 315                 320 


Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu 
                325                 330                 335     


His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln 
            340                 345                 350         


Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val 
        355                 360                 365             


Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser 
    370                 375                 380                 


Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg 
385                 390                 395                 400 


Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys 
                405                 410                 415     


His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu 
            420                 425                 430         


Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro 
        435                 440                 445             


Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val 
    450                 455                 460                 


Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys 
465                 470                 475                 480 


His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu 
                485                 490                 495     


Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His 
            500                 505                 510         


Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His 
        515                 520                 525             


Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro 
    530                 535                 540                 


Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu 
545                 550                 555                 560 


Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile 
                565                 570                 575     


Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu 
            580                 585                 590         


Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser 
        595                 600                 605             


Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn 
    610                 615                 620                 


Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe 
625                 630                 635                 640 


Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn 
                645                 650                 655     


Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn 
            660                 665                 670         


Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro 
        675                 680                 685             


Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu 
    690                 695                 700                 


Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly 
705                 710                 715                 720 


Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn 
                725                 730                 735     


Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro 
            740                 745                 750         


Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr 
        755                 760                 765             


Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His 
    770                 775                 780                 


Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser 
785                 790                 795                 800 


Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val 
                805                 810                 815     


Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val 
            820                 825                 830         


Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu 
        835                 840                 845             


Asp Leu Ile Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    850                 855                 860                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
865                 870                 875                 880 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                885                 890                 895     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            900                 905                 910         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        915                 920                 925             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    930                 935                 940                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
945                 950                 955                 960 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                965                 970                 975     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            980                 985                 990         


Asn Gln Val Ser Leu Thr Cys Leu  Val Lys Gly Phe Tyr  Pro Ser Asp 
        995                 1000                 1005             


Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln Pro Glu  Asn Asn Tyr 
    1010                 1015                 1020             


Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp Gly Ser  Phe Phe Leu 
    1025                 1030                 1035             


Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg Trp Gln  Gln Gly Asn 
    1040                 1045                 1050             


Val Phe  Ser Cys Ser Val Met  His Glu Ala Leu His  Asn His Tyr 
    1055                 1060                 1065             


Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly Lys 
    1070                 1075                 


<210>  21
<211>  1474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  - ENPP71 (lacking NPP1 N-Terminus GLK) - ALB Amino Acid Sequence


<220>
<221>  SIGNAL
<222>  (22)..(23)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (857)..(1474)

<220>
<221>  MISC_FEATURE
<222>  (857)..(1474)
<223>  Indicate Albumin sequence

<400>  21

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Ala Pro Ser Cys Ala Lys Glu Val Lys Ser Cys 
            20                  25                  30          


Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala 
        35                  40                  45              


Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys 
    50                  55                  60                  


Ile Glu Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu 
65                  70                  75                  80  


Lys Arg Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp 
                85                  90                  95      


Lys Gly Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys 
            100                 105                 110         


Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro 
        115                 120                 125             


Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe 
    130                 135                 140                 


Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser 
145                 150                 155                 160 


Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr 
                165                 170                 175     


Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr 
            180                 185                 190         


Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met 
        195                 200                 205             


Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp 
    210                 215                 220                 


Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys 
225                 230                 235                 240 


Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile 
                245                 250                 255     


Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu 
            260                 265                 270         


Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg 
        275                 280                 285             


Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His 
    290                 295                 300                 


Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val 
305                 310                 315                 320 


Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu 
                325                 330                 335     


His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln 
            340                 345                 350         


Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val 
        355                 360                 365             


Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser 
    370                 375                 380                 


Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg 
385                 390                 395                 400 


Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys 
                405                 410                 415     


His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu 
            420                 425                 430         


Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro 
        435                 440                 445             


Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val 
    450                 455                 460                 


Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys 
465                 470                 475                 480 


His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu 
                485                 490                 495     


Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His 
            500                 505                 510         


Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His 
        515                 520                 525             


Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro 
    530                 535                 540                 


Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu 
545                 550                 555                 560 


Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile 
                565                 570                 575     


Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu 
            580                 585                 590         


Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser 
        595                 600                 605             


Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn 
    610                 615                 620                 


Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe 
625                 630                 635                 640 


Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn 
                645                 650                 655     


Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn 
            660                 665                 670         


Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro 
        675                 680                 685             


Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu 
    690                 695                 700                 


Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly 
705                 710                 715                 720 


Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn 
                725                 730                 735     


Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro 
            740                 745                 750         


Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr 
        755                 760                 765             


Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His 
    770                 775                 780                 


Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser 
785                 790                 795                 800 


Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val 
                805                 810                 815     


Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val 
            820                 825                 830         


Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu 
        835                 840                 845             


Asp Arg Ser Gly Ser Gly Gly Ser Met Lys Trp Val Thr Phe Leu Leu 
    850                 855                 860                 


Leu Leu Phe Val Ser Gly Ser Ala Phe Ser Arg Gly Val Phe Arg Arg 
865                 870                 875                 880 


Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu 
                885                 890                 895     


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            900                 905                 910         


Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        915                 920                 925             


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    930                 935                 940                 


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
945                 950                 955                 960 


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                965                 970                 975     


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            980                 985                 990         


Pro Pro Phe Glu Arg Pro Glu Ala  Glu Ala Met Cys Thr  Ser Phe Lys 
        995                 1000                 1005             


Glu Asn  Pro Thr Thr Phe Met  Gly His Tyr Leu His  Glu Val Ala 
    1010                 1015                 1020             


Arg Arg  His Pro Tyr Phe Tyr  Ala Pro Glu Leu Leu  Tyr Tyr Ala 
    1025                 1030                 1035             


Glu Gln  Tyr Asn Glu Ile Leu  Thr Gln Cys Cys Ala  Glu Ala Asp 
    1040                 1045                 1050             


Lys Glu  Ser Cys Leu Thr Pro  Lys Leu Asp Gly Val  Lys Glu Lys 
    1055                 1060                 1065             


Ala Leu  Val Ser Ser Val Arg  Gln Arg Met Lys Cys  Ser Ser Met 
    1070                 1075                 1080             


Gln Lys  Phe Gly Glu Arg Ala  Phe Lys Ala Trp Ala  Val Ala Arg 
    1085                 1090                 1095             


Leu Ser  Gln Thr Phe Pro Asn  Ala Asp Phe Ala Glu  Ile Thr Lys 
    1100                 1105                 1110             


Leu Ala  Thr Asp Leu Thr Lys  Val Asn Lys Glu Cys  Cys His Gly 
    1115                 1120                 1125             


Asp Leu  Leu Glu Cys Ala Asp  Asp Arg Ala Glu Leu  Ala Lys Tyr 
    1130                 1135                 1140             


Met Cys  Glu Asn Gln Ala Thr  Ile Ser Ser Lys Leu  Gln Thr Cys 
    1145                 1150                 1155             


Cys Asp  Lys Pro Leu Leu Lys  Lys Ala His Cys Leu  Ser Glu Val 
    1160                 1165                 1170             


Glu His  Asp Thr Met Pro Ala  Asp Leu Pro Ala Ile  Ala Ala Asp 
    1175                 1180                 1185             


Phe Val  Glu Asp Gln Glu Val  Cys Lys Asn Tyr Ala  Glu Ala Lys 
    1190                 1195                 1200             


Asp Val  Phe Leu Gly Thr Phe  Leu Tyr Glu Tyr Ser  Arg Arg His 
    1205                 1210                 1215             


Pro Asp  Tyr Ser Val Ser Leu  Leu Leu Arg Leu Ala  Lys Lys Tyr 
    1220                 1225                 1230             


Glu Ala  Thr Leu Glu Lys Cys  Cys Ala Glu Ala Asn  Pro Pro Ala 
    1235                 1240                 1245             


Cys Tyr  Gly Thr Val Leu Ala  Glu Phe Gln Pro Leu  Val Glu Glu 
    1250                 1255                 1260             


Pro Lys  Asn Leu Val Lys Thr  Asn Cys Asp Leu Tyr  Glu Lys Leu 
    1265                 1270                 1275             


Gly Glu  Tyr Gly Phe Gln Asn  Ala Ile Leu Val Arg  Tyr Thr Gln 
    1280                 1285                 1290             


Lys Ala  Pro Gln Val Ser Thr  Pro Thr Leu Val Glu  Ala Ala Arg 
    1295                 1300                 1305             


Asn Leu  Gly Arg Val Gly Thr  Lys Cys Cys Thr Leu  Pro Glu Asp 
    1310                 1315                 1320             


Gln Arg  Leu Pro Cys Val Glu  Asp Tyr Leu Ser Ala  Ile Leu Asn 
    1325                 1330                 1335             


Arg Val  Cys Leu Leu His Glu  Lys Thr Pro Val Ser  Glu His Val 
    1340                 1345                 1350             


Thr Lys  Cys Cys Ser Gly Ser  Leu Val Glu Arg Arg  Pro Cys Phe 
    1355                 1360                 1365             


Ser Ala  Leu Thr Val Asp Glu  Thr Tyr Val Pro Lys  Glu Phe Lys 
    1370                 1375                 1380             


Ala Glu  Thr Phe Thr Phe His  Ser Asp Ile Cys Thr  Leu Pro Glu 
    1385                 1390                 1395             


Lys Glu  Lys Gln Ile Lys Lys  Gln Thr Ala Leu Ala  Glu Leu Val 
    1400                 1405                 1410             


Lys His  Lys Pro Lys Ala Thr  Ala Glu Gln Leu Lys  Thr Val Met 
    1415                 1420                 1425             


Asp Asp  Phe Ala Gln Phe Leu  Asp Thr Cys Cys Lys  Ala Ala Asp 
    1430                 1435                 1440             


Lys Asp  Thr Cys Phe Ser Thr  Glu Gly Pro Asn Leu  Val Thr Arg 
    1445                 1450                 1455             


Cys Lys  Asp Ala Leu Ala Arg  Ser Trp Ser His Pro  Gln Phe Glu 
    1460                 1465                 1470             


Lys 
    


<210>  22
<211>  1072
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP7-NPP3-Fc sequence


<220>
<221>  SIGNAL
<222>  (20)..(21)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (846)..(1072)
<223>  Indicate Fc sequence

<400>  22

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala 
            20                  25                  30          


Ser Phe Arg Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp 
        35                  40                  45              


Arg Gly Asp Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr 
    50                  55                  60                  


Arg Ile Trp Met Cys Asn Lys Phe Arg Cys Gly Glu Arg Leu Glu Ala 
65                  70                  75                  80  


Ser Leu Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys 
                85                  90                  95      


Ala Asp Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu 
            100                 105                 110         


Asn Cys Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu 
        115                 120                 125             


Pro Pro Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu 
    130                 135                 140                 


Tyr Thr Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys 
145                 150                 155                 160 


Gly Ile His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe 
                165                 170                 175     


Pro Asn His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly 
            180                 185                 190         


Ile Ile Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser 
        195                 200                 205             


Leu Ser Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro 
    210                 215                 220                 


Met Trp Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe 
225                 230                 235                 240 


Trp Pro Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr 
                245                 250                 255     


Met Pro Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu 
            260                 265                 270         


Leu Lys Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr 
        275                 280                 285             


Met Tyr Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val 
    290                 295                 300                 


Ser Ala Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly 
305                 310                 315                 320 


Met Leu Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn 
                325                 330                 335     


Ile Ile Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys 
            340                 345                 350         


Met Glu Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met 
        355                 360                 365             


Tyr Glu Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp 
    370                 375                 380                 


Phe Phe Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg 
385                 390                 395                 400 


Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys 
                405                 410                 415     


Arg Leu His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe 
            420                 425                 430         


Val Asp Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys 
        435                 440                 445             


Gly Gly Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala 
    450                 455                 460                 


Ile Phe Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu 
465                 470                 475                 480 


Pro Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg 
                485                 490                 495     


Ile Gln Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
            500                 505                 510         


Leu Lys Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys 
        515                 520                 525             


Phe Ser Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp 
    530                 535                 540                 


Cys Phe Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn 
545                 550                 555                 560 


Gln Met Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val 
                565                 570                 575     


Asn Leu Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His 
            580                 585                 590         


Cys Leu Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met 
        595                 600                 605             


Arg Met Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr 
    610                 615                 620                 


Ser Pro Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg 
625                 630                 635                 640 


Val Pro Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys 
                645                 650                 655     


Asn Ile Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser 
            660                 665                 670         


Asp Ser Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr 
        675                 680                 685             


Glu Glu Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile 
    690                 695                 700                 


Lys His Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile 
705                 710                 715                 720 


Phe Asp Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr 
                725                 730                 735     


Lys His Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val 
            740                 745                 750         


Val Leu Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro 
        755                 760                 765             


Gly Trp Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn 
    770                 775                 780                 


Val Glu Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu 
785                 790                 795                 800 


Arg Phe Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr 
                805                 810                 815     


Gly Leu Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu 
            820                 825                 830         


Gln Leu Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile Asp Lys Thr 
        835                 840                 845             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    850                 855                 860                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
865                 870                 875                 880 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                885                 890                 895     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            900                 905                 910         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        915                 920                 925             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    930                 935                 940                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
945                 950                 955                 960 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                965                 970                 975     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            980                 985                 990         


Leu Val Lys Gly Phe Tyr Pro Ser  Asp Ile Ala Val Glu  Trp Glu Ser 
        995                 1000                 1005             


Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr Thr Pro  Pro Val Leu 
    1010                 1015                 1020             


Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser Lys Leu  Thr Val Asp 
    1025                 1030                 1035             


Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe Ser Cys  Ser Val Met 
    1040                 1045                 1050             


His Glu  Ala Leu His Asn His  Tyr Thr Gln Lys Ser  Leu Ser Leu 
    1055                 1060                 1065             


Ser Pro  Gly Lys 
    1070         


<210>  23
<211>  1396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP71-Albumin


<220>
<221>  SIGNAL
<222>  (23)..(24)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (857)..(1396)
<223>  Indicate Fc sequence

<400>  23

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser 
            20                  25                  30          


Cys Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp 
        35                  40                  45              


Ala Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr 
    50                  55                  60                  


Cys Ile Glu Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly 
65                  70                  75                  80  


Glu Lys Arg Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys 
                85                  90                  95      


Asp Lys Gly Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu 
            100                 105                 110         


Lys Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys 
        115                 120                 125             


Pro Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly 
    130                 135                 140                 


Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile 
145                 150                 155                 160 


Ser Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val 
                165                 170                 175     


Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu 
            180                 185                 190         


Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys 
        195                 200                 205             


Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu 
    210                 215                 220                 


Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu 
225                 230                 235                 240 


Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly 
                245                 250                 255     


Ile Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu 
            260                 265                 270         


Glu Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu 
        275                 280                 285             


Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly 
    290                 295                 300                 


His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg 
305                 310                 315                 320 


Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn 
                325                 330                 335     


Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu 
            340                 345                 350         


Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp 
        355                 360                 365             


Val Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro 
    370                 375                 380                 


Ser Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala 
385                 390                 395                 400 


Arg Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu 
                405                 410                 415     


Lys His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile 
            420                 425                 430         


Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn 
        435                 440                 445             


Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn 
    450                 455                 460                 


Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe 
465                 470                 475                 480 


Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn 
                485                 490                 495     


Leu Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr 
            500                 505                 510         


His Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys 
        515                 520                 525             


His Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn 
    530                 535                 540                 


Pro Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile 
545                 550                 555                 560 


Glu Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile 
                565                 570                 575     


Ile Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys 
            580                 585                 590         


Glu Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr 
        595                 600                 605             


Ser Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg 
    610                 615                 620                 


Asn Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp 
625                 630                 635                 640 


Phe Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn 
                645                 650                 655     


Asn Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys 
            660                 665                 670         


Asn Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val 
        675                 680                 685             


Pro Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr 
    690                 695                 700                 


Leu Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser 
705                 710                 715                 720 


Gly Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu 
                725                 730                 735     


Asn Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile 
            740                 745                 750         


Pro Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln 
        755                 760                 765             


Thr Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro 
    770                 775                 780                 


His Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His Asp Ser 
785                 790                 795                 800 


Ser Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp 
                805                 810                 815     


Val Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro 
            820                 825                 830         


Val Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln 
        835                 840                 845             


Glu Asp Gly Gly Ser Gly Gly Ser Met Lys Trp Val Thr Phe Leu Leu 
    850                 855                 860                 


Leu Leu Phe Val Ser Gly Ser Ala Phe Ser Arg Gly Val Phe Arg Arg 
865                 870                 875                 880 


Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu 
                885                 890                 895     


Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            900                 905                 910         


Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr Asp 
        915                 920                 925             


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys 
    930                 935                 940                 


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn Leu 
945                 950                 955                 960 


Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu Pro 
                965                 970                 975     


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser Leu 
            980                 985                 990         


Pro Pro Phe Glu Arg Pro Glu Ala  Glu Ala Met Cys Thr  Ser Phe Lys 
        995                 1000                 1005             


Glu Asn  Pro Thr Thr Phe Met  Gly His Tyr Leu His  Glu Val Ala 
    1010                 1015                 1020             


Arg Arg  His Pro Tyr Phe Tyr  Ala Pro Glu Leu Leu  Tyr Tyr Ala 
    1025                 1030                 1035             


Glu Gln  Tyr Asn Glu Ile Leu  Thr Gln Cys Cys Ala  Glu Ala Asp 
    1040                 1045                 1050             


Lys Glu  Ser Cys Leu Thr Pro  Lys Leu Asp Gly Val  Lys Glu Lys 
    1055                 1060                 1065             


Ala Leu  Val Ser Ser Val Arg  Gln Arg Met Lys Cys  Ser Ser Met 
    1070                 1075                 1080             


Gln Lys  Phe Gly Glu Arg Ala  Phe Lys Ala Trp Ala  Val Ala Arg 
    1085                 1090                 1095             


Leu Ser  Gln Thr Phe Pro Asn  Ala Asp Phe Ala Glu  Ile Thr Lys 
    1100                 1105                 1110             


Leu Ala  Thr Asp Leu Thr Lys  Val Asn Lys Glu Cys  Cys His Gly 
    1115                 1120                 1125             


Asp Leu  Leu Glu Cys Ala Asp  Asp Arg Ala Glu Leu  Ala Lys Tyr 
    1130                 1135                 1140             


Met Cys  Glu Asn Gln Ala Thr  Ile Ser Ser Lys Leu  Gln Thr Cys 
    1145                 1150                 1155             


Cys Asp  Lys Pro Leu Leu Lys  Lys Ala His Cys Leu  Ser Glu Val 
    1160                 1165                 1170             


Glu His  Asp Thr Met Pro Ala  Asp Leu Pro Ala Ile  Ala Ala Asp 
    1175                 1180                 1185             


Phe Val  Glu Asp Gln Glu Val  Cys Lys Asn Tyr Ala  Glu Ala Lys 
    1190                 1195                 1200             


Asp Val  Phe Leu Gly Thr Phe  Leu Tyr Glu Tyr Ser  Arg Arg His 
    1205                 1210                 1215             


Pro Asp  Tyr Ser Val Ser Leu  Leu Leu Arg Leu Ala  Lys Lys Tyr 
    1220                 1225                 1230             


Glu Ala  Thr Leu Glu Lys Cys  Cys Ala Glu Ala Asn  Pro Pro Ala 
    1235                 1240                 1245             


Cys Tyr  Gly Thr Val Leu Ala  Glu Phe Gln Pro Leu  Val Glu Glu 
    1250                 1255                 1260             


Pro Lys  Asn Leu Val Lys Thr  Asn Cys Asp Leu Tyr  Glu Lys Leu 
    1265                 1270                 1275             


Gly Glu  Tyr Gly Phe Gln Asn  Ala Ile Leu Val Arg  Tyr Thr Gln 
    1280                 1285                 1290             


Lys Ala  Pro Gln Val Ser Thr  Pro Thr Leu Val Glu  Ala Ala Arg 
    1295                 1300                 1305             


Asn Leu  Gly Arg Val Gly Thr  Lys Cys Cys Thr Leu  Pro Glu Asp 
    1310                 1315                 1320             


Gln Arg  Leu Pro Cys Val Glu  Asp Tyr Leu Ser Ala  Ile Leu Asn 
    1325                 1330                 1335             


Arg Val  Cys Leu Leu His Glu  Lys Thr Pro Val Ser  Glu His Val 
    1340                 1345                 1350             


Thr Lys  Cys Cys Ser Gly Ser  Leu Val Glu Arg Arg  Pro Cys Phe 
    1355                 1360                 1365             


Ser Ala  Leu Thr Val Asp Glu  Thr Tyr Val Pro Lys  Glu Phe Lys 
    1370                 1375                 1380             


Ala Glu  Thr Phe Thr Phe His  Ser Asp Ile Cys Thr  Leu 
    1385                 1390                 1395     


<210>  24
<211>  1467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP7-NPP3-Albumin


<220>
<221>  SIGNAL
<222>  (20)..(21)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (860)..(1467)
<223>  Indicate Albumin sequence

<400>  24

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala 
            20                  25                  30          


Ser Phe Arg Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp 
        35                  40                  45              


Arg Gly Asp Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr 
    50                  55                  60                  


Arg Ile Trp Met Cys Asn Lys Phe Arg Cys Gly Glu Arg Leu Glu Ala 
65                  70                  75                  80  


Ser Leu Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys 
                85                  90                  95      


Ala Asp Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu 
            100                 105                 110         


Asn Cys Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu 
        115                 120                 125             


Pro Pro Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu 
    130                 135                 140                 


Tyr Thr Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys 
145                 150                 155                 160 


Gly Ile His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe 
                165                 170                 175     


Pro Asn His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly 
            180                 185                 190         


Ile Ile Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser 
        195                 200                 205             


Leu Ser Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro 
    210                 215                 220                 


Met Trp Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe 
225                 230                 235                 240 


Trp Pro Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr 
                245                 250                 255     


Met Pro Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu 
            260                 265                 270         


Leu Lys Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr 
        275                 280                 285             


Met Tyr Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val 
    290                 295                 300                 


Ser Ala Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly 
305                 310                 315                 320 


Met Leu Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn 
                325                 330                 335     


Ile Ile Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys 
            340                 345                 350         


Met Glu Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met 
        355                 360                 365             


Tyr Glu Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp 
    370                 375                 380                 


Phe Phe Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg 
385                 390                 395                 400 


Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys 
                405                 410                 415     


Arg Leu His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe 
            420                 425                 430         


Val Asp Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys 
        435                 440                 445             


Gly Gly Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala 
    450                 455                 460                 


Ile Phe Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu 
465                 470                 475                 480 


Pro Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg 
                485                 490                 495     


Ile Gln Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
            500                 505                 510         


Leu Lys Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys 
        515                 520                 525             


Phe Ser Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp 
    530                 535                 540                 


Cys Phe Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn 
545                 550                 555                 560 


Gln Met Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val 
                565                 570                 575     


Asn Leu Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His 
            580                 585                 590         


Cys Leu Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met 
        595                 600                 605             


Arg Met Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr 
    610                 615                 620                 


Ser Pro Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg 
625                 630                 635                 640 


Val Pro Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys 
                645                 650                 655     


Asn Ile Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser 
            660                 665                 670         


Asp Ser Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr 
        675                 680                 685             


Glu Glu Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile 
    690                 695                 700                 


Lys His Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile 
705                 710                 715                 720 


Phe Asp Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr 
                725                 730                 735     


Lys His Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val 
            740                 745                 750         


Val Leu Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro 
        755                 760                 765             


Gly Trp Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn 
    770                 775                 780                 


Val Glu Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu 
785                 790                 795                 800 


Arg Phe Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr 
                805                 810                 815     


Gly Leu Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu 
            820                 825                 830         


Gln Leu Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile Gly Gly Gly 
        835                 840                 845             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Lys Trp Val Thr 
    850                 855                 860                 


Phe Leu Leu Leu Leu Phe Val Ser Gly Ser Ala Phe Ser Arg Gly Val 
865                 870                 875                 880 


Phe Arg Arg Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp 
                885                 890                 895     


Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln 
            900                 905                 910         


Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu 
        915                 920                 925             


Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn 
    930                 935                 940                 


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile 
945                 950                 955                 960 


Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys 
                965                 970                 975     


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
            980                 985                 990         


Pro Ser Leu Pro Pro Phe Glu Arg  Pro Glu Ala Glu Ala  Met Cys Thr 
        995                 1000                 1005             


Ser Phe  Lys Glu Asn Pro Thr  Thr Phe Met Gly His  Tyr Leu His 
    1010                 1015                 1020             


Glu Val  Ala Arg Arg His Pro  Tyr Phe Tyr Ala Pro  Glu Leu Leu 
    1025                 1030                 1035             


Tyr Tyr  Ala Glu Gln Tyr Asn  Glu Ile Leu Thr Gln  Cys Cys Ala 
    1040                 1045                 1050             


Glu Ala  Asp Lys Glu Ser Cys  Leu Thr Pro Lys Leu  Asp Gly Val 
    1055                 1060                 1065             


Lys Glu  Lys Ala Leu Val Ser  Ser Val Arg Gln Arg  Met Lys Cys 
    1070                 1075                 1080             


Ser Ser  Met Gln Lys Phe Gly  Glu Arg Ala Phe Lys  Ala Trp Ala 
    1085                 1090                 1095             


Val Ala  Arg Leu Ser Gln Thr  Phe Pro Asn Ala Asp  Phe Ala Glu 
    1100                 1105                 1110             


Ile Thr  Lys Leu Ala Thr Asp  Leu Thr Lys Val Asn  Lys Glu Cys 
    1115                 1120                 1125             


Cys His  Gly Asp Leu Leu Glu  Cys Ala Asp Asp Arg  Ala Glu Leu 
    1130                 1135                 1140             


Ala Lys  Tyr Met Cys Glu Asn  Gln Ala Thr Ile Ser  Ser Lys Leu 
    1145                 1150                 1155             


Gln Thr  Cys Cys Asp Lys Pro  Leu Leu Lys Lys Ala  His Cys Leu 
    1160                 1165                 1170             


Ser Glu  Val Glu His Asp Thr  Met Pro Ala Asp Leu  Pro Ala Ile 
    1175                 1180                 1185             


Ala Ala  Asp Phe Val Glu Asp  Gln Glu Val Cys Lys  Asn Tyr Ala 
    1190                 1195                 1200             


Glu Ala  Lys Asp Val Phe Leu  Gly Thr Phe Leu Tyr  Glu Tyr Ser 
    1205                 1210                 1215             


Arg Arg  His Pro Asp Tyr Ser  Val Ser Leu Leu Leu  Arg Leu Ala 
    1220                 1225                 1230             


Lys Lys  Tyr Glu Ala Thr Leu  Glu Lys Cys Cys Ala  Glu Ala Asn 
    1235                 1240                 1245             


Pro Pro  Ala Cys Tyr Gly Thr  Val Leu Ala Glu Phe  Gln Pro Leu 
    1250                 1255                 1260             


Val Glu  Glu Pro Lys Asn Leu  Val Lys Thr Asn Cys  Asp Leu Tyr 
    1265                 1270                 1275             


Glu Lys  Leu Gly Glu Tyr Gly  Phe Gln Asn Ala Ile  Leu Val Arg 
    1280                 1285                 1290             


Tyr Thr  Gln Lys Ala Pro Gln  Val Ser Thr Pro Thr  Leu Val Glu 
    1295                 1300                 1305             


Ala Ala  Arg Asn Leu Gly Arg  Val Gly Thr Lys Cys  Cys Thr Leu 
    1310                 1315                 1320             


Pro Glu  Asp Gln Arg Leu Pro  Cys Val Glu Asp Tyr  Leu Ser Ala 
    1325                 1330                 1335             


Ile Leu  Asn Arg Val Cys Leu  Leu His Glu Lys Thr  Pro Val Ser 
    1340                 1345                 1350             


Glu His  Val Thr Lys Cys Cys  Ser Gly Ser Leu Val  Glu Arg Arg 
    1355                 1360                 1365             


Pro Cys  Phe Ser Ala Leu Thr  Val Asp Glu Thr Tyr  Val Pro Lys 
    1370                 1375                 1380             


Glu Phe  Lys Ala Glu Thr Phe  Thr Phe His Ser Asp  Ile Cys Thr 
    1385                 1390                 1395             


Leu Pro  Glu Lys Glu Lys Gln  Ile Lys Lys Gln Thr  Ala Leu Ala 
    1400                 1405                 1410             


Glu Leu  Val Lys His Lys Pro  Lys Ala Thr Ala Glu  Gln Leu Lys 
    1415                 1420                 1425             


Thr Val  Met Asp Asp Phe Ala  Gln Phe Leu Asp Thr  Cys Cys Lys 
    1430                 1435                 1440             


Ala Ala  Asp Lys Asp Thr Cys  Phe Ser Thr Glu Gly  Pro Asn Leu 
    1445                 1450                 1455             


Val Thr  Arg Cys Lys Asp Ala  Leu Ala 
    1460                 1465         


<210>  25
<211>  1507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP7-ENPP3-Albumin


<220>
<221>  SIGNAL
<222>  (20)..(21)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (900)..(1507)

<400>  25

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala 
            20                  25                  30          


Ser Phe Arg Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp 
        35                  40                  45              


Arg Gly Asp Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr 
    50                  55                  60                  


Arg Ile Trp Met Cys Asn Lys Phe Arg Cys Gly Glu Arg Leu Glu Ala 
65                  70                  75                  80  


Ser Leu Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys 
                85                  90                  95      


Ala Asp Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu 
            100                 105                 110         


Asn Cys Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu 
        115                 120                 125             


Pro Pro Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu 
    130                 135                 140                 


Tyr Thr Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys 
145                 150                 155                 160 


Gly Ile His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe 
                165                 170                 175     


Pro Asn His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly 
            180                 185                 190         


Ile Ile Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser 
        195                 200                 205             


Leu Ser Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro 
    210                 215                 220                 


Met Trp Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe 
225                 230                 235                 240 


Trp Pro Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr 
                245                 250                 255     


Met Pro Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu 
            260                 265                 270         


Leu Lys Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr 
        275                 280                 285             


Met Tyr Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val 
    290                 295                 300                 


Ser Ala Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly 
305                 310                 315                 320 


Met Leu Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn 
                325                 330                 335     


Ile Ile Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys 
            340                 345                 350         


Met Glu Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met 
        355                 360                 365             


Tyr Glu Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp 
    370                 375                 380                 


Phe Phe Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg 
385                 390                 395                 400 


Lys Pro Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys 
                405                 410                 415     


Arg Leu His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe 
            420                 425                 430         


Val Asp Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys 
        435                 440                 445             


Gly Gly Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala 
    450                 455                 460                 


Ile Phe Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu 
465                 470                 475                 480 


Pro Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg 
                485                 490                 495     


Ile Gln Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu 
            500                 505                 510         


Leu Lys Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys 
        515                 520                 525             


Phe Ser Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp 
    530                 535                 540                 


Cys Phe Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn 
545                 550                 555                 560 


Gln Met Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val 
                565                 570                 575     


Asn Leu Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His 
            580                 585                 590         


Cys Leu Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met 
        595                 600                 605             


Arg Met Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr 
    610                 615                 620                 


Ser Pro Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg 
625                 630                 635                 640 


Val Pro Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys 
                645                 650                 655     


Asn Ile Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser 
            660                 665                 670         


Asp Ser Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr 
        675                 680                 685             


Glu Glu Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile 
    690                 695                 700                 


Lys His Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile 
705                 710                 715                 720 


Phe Asp Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr 
                725                 730                 735     


Lys His Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val 
            740                 745                 750         


Val Leu Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro 
        755                 760                 765             


Gly Trp Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn 
    770                 775                 780                 


Val Glu Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu 
785                 790                 795                 800 


Arg Phe Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr 
                805                 810                 815     


Gly Leu Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu 
            820                 825                 830         


Gln Leu Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile Asp Lys Thr 
        835                 840                 845             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    850                 855                 860                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
865                 870                 875                 880 


Thr Pro Glu Val Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                885                 890                 895     


Gly Gly Ser Met Lys Trp Val Thr Phe Leu Leu Leu Leu Phe Val Ser 
            900                 905                 910         


Gly Ser Ala Phe Ser Arg Gly Val Phe Arg Arg Glu Ala His Lys Ser 
        915                 920                 925             


Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly 
    930                 935                 940                 


Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp 
945                 950                 955                 960 


Glu His Ala Lys Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys 
                965                 970                 975     


Val Ala Asp Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu 
            980                 985                 990         


Phe Gly Asp Lys Leu Cys Ala Ile  Pro Asn Leu Arg Glu  Asn Tyr Gly 
        995                 1000                 1005             


Glu Leu  Ala Asp Cys Cys Thr  Lys Gln Glu Pro Glu  Arg Asn Glu 
    1010                 1015                 1020             


Cys Phe  Leu Gln His Lys Asp  Asp Asn Pro Ser Leu  Pro Pro Phe 
    1025                 1030                 1035             


Glu Arg  Pro Glu Ala Glu Ala  Met Cys Thr Ser Phe  Lys Glu Asn 
    1040                 1045                 1050             


Pro Thr  Thr Phe Met Gly His  Tyr Leu His Glu Val  Ala Arg Arg 
    1055                 1060                 1065             


His Pro  Tyr Phe Tyr Ala Pro  Glu Leu Leu Tyr Tyr  Ala Glu Gln 
    1070                 1075                 1080             


Tyr Asn  Glu Ile Leu Thr Gln  Cys Cys Ala Glu Ala  Asp Lys Glu 
    1085                 1090                 1095             


Ser Cys  Leu Thr Pro Lys Leu  Asp Gly Val Lys Glu  Lys Ala Leu 
    1100                 1105                 1110             


Val Ser  Ser Val Arg Gln Arg  Met Lys Cys Ser Ser  Met Gln Lys 
    1115                 1120                 1125             


Phe Gly  Glu Arg Ala Phe Lys  Ala Trp Ala Val Ala  Arg Leu Ser 
    1130                 1135                 1140             


Gln Thr  Phe Pro Asn Ala Asp  Phe Ala Glu Ile Thr  Lys Leu Ala 
    1145                 1150                 1155             


Thr Asp  Leu Thr Lys Val Asn  Lys Glu Cys Cys His  Gly Asp Leu 
    1160                 1165                 1170             


Leu Glu  Cys Ala Asp Asp Arg  Ala Glu Leu Ala Lys  Tyr Met Cys 
    1175                 1180                 1185             


Glu Asn  Gln Ala Thr Ile Ser  Ser Lys Leu Gln Thr  Cys Cys Asp 
    1190                 1195                 1200             


Lys Pro  Leu Leu Lys Lys Ala  His Cys Leu Ser Glu  Val Glu His 
    1205                 1210                 1215             


Asp Thr  Met Pro Ala Asp Leu  Pro Ala Ile Ala Ala  Asp Phe Val 
    1220                 1225                 1230             


Glu Asp  Gln Glu Val Cys Lys  Asn Tyr Ala Glu Ala  Lys Asp Val 
    1235                 1240                 1245             


Phe Leu  Gly Thr Phe Leu Tyr  Glu Tyr Ser Arg Arg  His Pro Asp 
    1250                 1255                 1260             


Tyr Ser  Val Ser Leu Leu Leu  Arg Leu Ala Lys Lys  Tyr Glu Ala 
    1265                 1270                 1275             


Thr Leu  Glu Lys Cys Cys Ala  Glu Ala Asn Pro Pro  Ala Cys Tyr 
    1280                 1285                 1290             


Gly Thr  Val Leu Ala Glu Phe  Gln Pro Leu Val Glu  Glu Pro Lys 
    1295                 1300                 1305             


Asn Leu  Val Lys Thr Asn Cys  Asp Leu Tyr Glu Lys  Leu Gly Glu 
    1310                 1315                 1320             


Tyr Gly  Phe Gln Asn Ala Ile  Leu Val Arg Tyr Thr  Gln Lys Ala 
    1325                 1330                 1335             


Pro Gln  Val Ser Thr Pro Thr  Leu Val Glu Ala Ala  Arg Asn Leu 
    1340                 1345                 1350             


Gly Arg  Val Gly Thr Lys Cys  Cys Thr Leu Pro Glu  Asp Gln Arg 
    1355                 1360                 1365             


Leu Pro  Cys Val Glu Asp Tyr  Leu Ser Ala Ile Leu  Asn Arg Val 
    1370                 1375                 1380             


Cys Leu  Leu His Glu Lys Thr  Pro Val Ser Glu His  Val Thr Lys 
    1385                 1390                 1395             


Cys Cys  Ser Gly Ser Leu Val  Glu Arg Arg Pro Cys  Phe Ser Ala 
    1400                 1405                 1410             


Leu Thr  Val Asp Glu Thr Tyr  Val Pro Lys Glu Phe  Lys Ala Glu 
    1415                 1420                 1425             


Thr Phe  Thr Phe His Ser Asp  Ile Cys Thr Leu Pro  Glu Lys Glu 
    1430                 1435                 1440             


Lys Gln  Ile Lys Lys Gln Thr  Ala Leu Ala Glu Leu  Val Lys His 
    1445                 1450                 1455             


Lys Pro  Lys Ala Thr Ala Glu  Gln Leu Lys Thr Val  Met Asp Asp 
    1460                 1465                 1470             


Phe Ala  Gln Phe Leu Asp Thr  Cys Cys Lys Ala Ala  Asp Lys Asp 
    1475                 1480                 1485             


Thr Cys  Phe Ser Thr Glu Gly  Pro Asn Leu Val Thr  Arg Cys Lys 
    1490                 1495                 1500             


Asp Ala  Leu Ala 
    1505         


<210>  26
<211>  852
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP71 Amino Acid Sequence


<220>
<221>  SIGNAL
<222>  (22)..(23)
<223>  Cleavage point of the signal peptide sequence

<400>  26

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Ala Gly Leu Lys Pro Ser Cys Ala Lys Glu Val 
            20                  25                  30          


Lys Ser Cys Lys Gly Arg Cys Phe Glu Arg Thr Phe Gly Asn Cys Arg 
        35                  40                  45              


Cys Asp Ala Ala Cys Val Glu Leu Gly Asn Cys Cys Leu Asp Tyr Gln 
    50                  55                  60                  


Glu Thr Cys Ile Glu Pro Glu His Ile Trp Thr Cys Asn Lys Phe Arg 
65                  70                  75                  80  


Cys Gly Glu Lys Arg Leu Thr Arg Ser Leu Cys Ala Cys Ser Asp Asp 
                85                  90                  95      


Cys Lys Asp Lys Gly Asp Cys Cys Ile Asn Tyr Ser Ser Val Cys Gln 
            100                 105                 110         


Gly Glu Lys Ser Trp Val Glu Glu Pro Cys Glu Ser Ile Asn Glu Pro 
        115                 120                 125             


Gln Cys Pro Ala Gly Phe Glu Thr Pro Pro Thr Leu Leu Phe Ser Leu 
    130                 135                 140                 


Asp Gly Phe Arg Ala Glu Tyr Leu His Thr Trp Gly Gly Leu Leu Pro 
145                 150                 155                 160 


Val Ile Ser Lys Leu Lys Lys Cys Gly Thr Tyr Thr Lys Asn Met Arg 
                165                 170                 175     


Pro Val Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr 
            180                 185                 190         


Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Lys Met Tyr Asp 
        195                 200                 205             


Pro Lys Met Asn Ala Ser Phe Ser Leu Lys Ser Lys Glu Lys Phe Asn 
    210                 215                 220                 


Pro Glu Trp Tyr Lys Gly Glu Pro Ile Trp Val Thr Ala Lys Tyr Gln 
225                 230                 235                 240 


Gly Leu Lys Ser Gly Thr Phe Phe Trp Pro Gly Ser Asp Val Glu Ile 
                245                 250                 255     


Asn Gly Ile Phe Pro Asp Ile Tyr Lys Met Tyr Asn Gly Ser Val Pro 
            260                 265                 270         


Phe Glu Glu Arg Ile Leu Ala Val Leu Gln Trp Leu Gln Leu Pro Lys 
        275                 280                 285             


Asp Glu Arg Pro His Phe Tyr Thr Leu Tyr Leu Glu Glu Pro Asp Ser 
    290                 295                 300                 


Ser Gly His Ser Tyr Gly Pro Val Ser Ser Glu Val Ile Lys Ala Leu 
305                 310                 315                 320 


Gln Arg Val Asp Gly Met Val Gly Met Leu Met Asp Gly Leu Lys Glu 
                325                 330                 335     


Leu Asn Leu His Arg Cys Leu Asn Leu Ile Leu Ile Ser Asp His Gly 
            340                 345                 350         


Met Glu Gln Gly Ser Cys Lys Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu 
        355                 360                 365             


Gly Asp Val Lys Asn Ile Lys Val Ile Tyr Gly Pro Ala Ala Arg Leu 
    370                 375                 380                 


Arg Pro Ser Asp Val Pro Asp Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly 
385                 390                 395                 400 


Ile Ala Arg Asn Leu Ser Cys Arg Glu Pro Asn Gln His Phe Lys Pro 
                405                 410                 415     


Tyr Leu Lys His Phe Leu Pro Lys Arg Leu His Phe Ala Lys Ser Asp 
            420                 425                 430         


Arg Ile Glu Pro Leu Thr Phe Tyr Leu Asp Pro Gln Trp Gln Leu Ala 
        435                 440                 445             


Leu Asn Pro Ser Glu Arg Lys Tyr Cys Gly Ser Gly Phe His Gly Ser 
    450                 455                 460                 


Asp Asn Val Phe Ser Asn Met Gln Ala Leu Phe Val Gly Tyr Gly Pro 
465                 470                 475                 480 


Gly Phe Lys His Gly Ile Glu Ala Asp Thr Phe Glu Asn Ile Glu Val 
                485                 490                 495     


Tyr Asn Leu Met Cys Asp Leu Leu Asn Leu Thr Pro Ala Pro Asn Asn 
            500                 505                 510         


Gly Thr His Gly Ser Leu Asn His Leu Leu Lys Asn Pro Val Tyr Thr 
        515                 520                 525             


Pro Lys His Pro Lys Glu Val His Pro Leu Val Gln Cys Pro Phe Thr 
    530                 535                 540                 


Arg Asn Pro Arg Asp Asn Leu Gly Cys Ser Cys Asn Pro Ser Ile Leu 
545                 550                 555                 560 


Pro Ile Glu Asp Phe Gln Thr Gln Phe Asn Leu Thr Val Ala Glu Glu 
                565                 570                 575     


Lys Ile Ile Lys His Glu Thr Leu Pro Tyr Gly Arg Pro Arg Val Leu 
            580                 585                 590         


Gln Lys Glu Asn Thr Ile Cys Leu Leu Ser Gln His Gln Phe Met Ser 
        595                 600                 605             


Gly Tyr Ser Gln Asp Ile Leu Met Pro Leu Trp Thr Ser Tyr Thr Val 
    610                 615                 620                 


Asp Arg Asn Asp Ser Phe Ser Thr Glu Asp Phe Ser Asn Cys Leu Tyr 
625                 630                 635                 640 


Gln Asp Phe Arg Ile Pro Leu Ser Pro Val His Lys Cys Ser Phe Tyr 
                645                 650                 655     


Lys Asn Asn Thr Lys Val Ser Tyr Gly Phe Leu Ser Pro Pro Gln Leu 
            660                 665                 670         


Asn Lys Asn Ser Ser Gly Ile Tyr Ser Glu Ala Leu Leu Thr Thr Asn 
        675                 680                 685             


Ile Val Pro Met Tyr Gln Ser Phe Gln Val Ile Trp Arg Tyr Phe His 
    690                 695                 700                 


Asp Thr Leu Leu Arg Lys Tyr Ala Glu Glu Arg Asn Gly Val Asn Val 
705                 710                 715                 720 


Val Ser Gly Pro Val Phe Asp Phe Asp Tyr Asp Gly Arg Cys Asp Ser 
                725                 730                 735     


Leu Glu Asn Leu Arg Gln Lys Arg Arg Val Ile Arg Asn Gln Glu Ile 
            740                 745                 750         


Leu Ile Pro Thr His Phe Phe Ile Val Leu Thr Ser Cys Lys Asp Thr 
        755                 760                 765             


Ser Gln Thr Pro Leu His Cys Glu Asn Leu Asp Thr Leu Ala Phe Ile 
    770                 775                 780                 


Leu Pro His Arg Thr Asp Asn Ser Glu Ser Cys Val His Gly Lys His 
785                 790                 795                 800 


Asp Ser Ser Trp Val Glu Glu Leu Leu Met Leu His Arg Ala Arg Ile 
                805                 810                 815     


Thr Asp Val Glu His Ile Thr Gly Leu Ser Phe Tyr Gln Gln Arg Lys 
            820                 825                 830         


Glu Pro Val Ser Asp Ile Leu Lys Leu Lys Thr His Leu Pro Thr Phe 
        835                 840                 845             


Ser Gln Glu Asp 
    850         


<210>  27
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP121 Amino Acid Sequence


<220>
<221>  SIGNAL
<222>  (92)..(93)
<223>  Cleavage point of the signal peptide sequence

<400>  27

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Ile Ile Ser Leu 
65                  70                  75                  80  


Phe Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp 
        915                 920                 925 


<210>  28
<211>  1155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP121-Fc Amino Acid Sequence


<220>
<221>  SIGNAL
<222>  (92)..(93)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (929)..(1155)
<223>  Indicate Fc sequence

<400>  28

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Ile Ile Ser Leu 
65                  70                  75                  80  


Phe Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Leu Ile Asn 
        915                 920                 925             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    930                 935                 940                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
945                 950                 955                 960 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                965                 970                 975     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            980                 985                 990         


His Asn Ala Lys Thr Lys Pro Arg  Glu Glu Gln Tyr Asn  Ser Thr Tyr 
        995                 1000                 1005             


Arg Val  Val Ser Val Leu Thr  Val Leu His Gln Asp  Trp Leu Asn 
    1010                 1015                 1020             


Gly Lys  Glu Tyr Lys Cys Lys  Val Ser Asn Lys Ala  Leu Pro Ala 
    1025                 1030                 1035             


Pro Ile  Glu Lys Thr Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu 
    1040                 1045                 1050             


Pro Gln  Val Tyr Thr Leu Pro  Pro Ser Arg Glu Glu  Met Thr Lys 
    1055                 1060                 1065             


Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser 
    1070                 1075                 1080             


Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn 
    1085                 1090                 1095             


Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe 
    1100                 1105                 1110             


Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly 
    1115                 1120                 1125             


Asn Val  Phe Ser Cys Ser Val  Met His Glu Ala Leu  His Asn His 
    1130                 1135                 1140             


Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro Gly Lys  
    1145                 1150                 1155 


<210>  29
<211>  1550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP121-ALB Amino Acid Sequence


<220>
<221>  SIGNAL
<222>  (92)..(93)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (933)..(1550)
<223>  Indicate Albumin sequence

<400>  29

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Ile Ile Ser Leu 
65                  70                  75                  80  


Phe Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala Gly 
                85                  90                  95      


Leu Lys Pro Ser Cys Ala Lys Glu Val Lys Ser Cys Lys Gly Arg Cys 
            100                 105                 110         


Phe Glu Arg Thr Phe Gly Asn Cys Arg Cys Asp Ala Ala Cys Val Glu 
        115                 120                 125             


Leu Gly Asn Cys Cys Leu Asp Tyr Gln Glu Thr Cys Ile Glu Pro Glu 
    130                 135                 140                 


His Ile Trp Thr Cys Asn Lys Phe Arg Cys Gly Glu Lys Arg Leu Thr 
145                 150                 155                 160 


Arg Ser Leu Cys Ala Cys Ser Asp Asp Cys Lys Asp Lys Gly Asp Cys 
                165                 170                 175     


Cys Ile Asn Tyr Ser Ser Val Cys Gln Gly Glu Lys Ser Trp Val Glu 
            180                 185                 190         


Glu Pro Cys Glu Ser Ile Asn Glu Pro Gln Cys Pro Ala Gly Phe Glu 
        195                 200                 205             


Thr Pro Pro Thr Leu Leu Phe Ser Leu Asp Gly Phe Arg Ala Glu Tyr 
    210                 215                 220                 


Leu His Thr Trp Gly Gly Leu Leu Pro Val Ile Ser Lys Leu Lys Lys 
225                 230                 235                 240 


Cys Gly Thr Tyr Thr Lys Asn Met Arg Pro Val Tyr Pro Thr Lys Thr 
                245                 250                 255     


Phe Pro Asn His Tyr Ser Ile Val Thr Gly Leu Tyr Pro Glu Ser His 
            260                 265                 270         


Gly Ile Ile Asp Asn Lys Met Tyr Asp Pro Lys Met Asn Ala Ser Phe 
        275                 280                 285             


Ser Leu Lys Ser Lys Glu Lys Phe Asn Pro Glu Trp Tyr Lys Gly Glu 
    290                 295                 300                 


Pro Ile Trp Val Thr Ala Lys Tyr Gln Gly Leu Lys Ser Gly Thr Phe 
305                 310                 315                 320 


Phe Trp Pro Gly Ser Asp Val Glu Ile Asn Gly Ile Phe Pro Asp Ile 
                325                 330                 335     


Tyr Lys Met Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Leu Ala 
            340                 345                 350         


Val Leu Gln Trp Leu Gln Leu Pro Lys Asp Glu Arg Pro His Phe Tyr 
        355                 360                 365             


Thr Leu Tyr Leu Glu Glu Pro Asp Ser Ser Gly His Ser Tyr Gly Pro 
    370                 375                 380                 


Val Ser Ser Glu Val Ile Lys Ala Leu Gln Arg Val Asp Gly Met Val 
385                 390                 395                 400 


Gly Met Leu Met Asp Gly Leu Lys Glu Leu Asn Leu His Arg Cys Leu 
                405                 410                 415     


Asn Leu Ile Leu Ile Ser Asp His Gly Met Glu Gln Gly Ser Cys Lys 
            420                 425                 430         


Lys Tyr Ile Tyr Leu Asn Lys Tyr Leu Gly Asp Val Lys Asn Ile Lys 
        435                 440                 445             


Val Ile Tyr Gly Pro Ala Ala Arg Leu Arg Pro Ser Asp Val Pro Asp 
    450                 455                 460                 


Lys Tyr Tyr Ser Phe Asn Tyr Glu Gly Ile Ala Arg Asn Leu Ser Cys 
465                 470                 475                 480 


Arg Glu Pro Asn Gln His Phe Lys Pro Tyr Leu Lys His Phe Leu Pro 
                485                 490                 495     


Lys Arg Leu His Phe Ala Lys Ser Asp Arg Ile Glu Pro Leu Thr Phe 
            500                 505                 510         


Tyr Leu Asp Pro Gln Trp Gln Leu Ala Leu Asn Pro Ser Glu Arg Lys 
        515                 520                 525             


Tyr Cys Gly Ser Gly Phe His Gly Ser Asp Asn Val Phe Ser Asn Met 
    530                 535                 540                 


Gln Ala Leu Phe Val Gly Tyr Gly Pro Gly Phe Lys His Gly Ile Glu 
545                 550                 555                 560 


Ala Asp Thr Phe Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu 
                565                 570                 575     


Leu Asn Leu Thr Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn 
            580                 585                 590         


His Leu Leu Lys Asn Pro Val Tyr Thr Pro Lys His Pro Lys Glu Val 
        595                 600                 605             


His Pro Leu Val Gln Cys Pro Phe Thr Arg Asn Pro Arg Asp Asn Leu 
    610                 615                 620                 


Gly Cys Ser Cys Asn Pro Ser Ile Leu Pro Ile Glu Asp Phe Gln Thr 
625                 630                 635                 640 


Gln Phe Asn Leu Thr Val Ala Glu Glu Lys Ile Ile Lys His Glu Thr 
                645                 650                 655     


Leu Pro Tyr Gly Arg Pro Arg Val Leu Gln Lys Glu Asn Thr Ile Cys 
            660                 665                 670         


Leu Leu Ser Gln His Gln Phe Met Ser Gly Tyr Ser Gln Asp Ile Leu 
        675                 680                 685             


Met Pro Leu Trp Thr Ser Tyr Thr Val Asp Arg Asn Asp Ser Phe Ser 
    690                 695                 700                 


Thr Glu Asp Phe Ser Asn Cys Leu Tyr Gln Asp Phe Arg Ile Pro Leu 
705                 710                 715                 720 


Ser Pro Val His Lys Cys Ser Phe Tyr Lys Asn Asn Thr Lys Val Ser 
                725                 730                 735     


Tyr Gly Phe Leu Ser Pro Pro Gln Leu Asn Lys Asn Ser Ser Gly Ile 
            740                 745                 750         


Tyr Ser Glu Ala Leu Leu Thr Thr Asn Ile Val Pro Met Tyr Gln Ser 
        755                 760                 765             


Phe Gln Val Ile Trp Arg Tyr Phe His Asp Thr Leu Leu Arg Lys Tyr 
    770                 775                 780                 


Ala Glu Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Val Phe Asp 
785                 790                 795                 800 


Phe Asp Tyr Asp Gly Arg Cys Asp Ser Leu Glu Asn Leu Arg Gln Lys 
                805                 810                 815     


Arg Arg Val Ile Arg Asn Gln Glu Ile Leu Ile Pro Thr His Phe Phe 
            820                 825                 830         


Ile Val Leu Thr Ser Cys Lys Asp Thr Ser Gln Thr Pro Leu His Cys 
        835                 840                 845             


Glu Asn Leu Asp Thr Leu Ala Phe Ile Leu Pro His Arg Thr Asp Asn 
    850                 855                 860                 


Ser Glu Ser Cys Val His Gly Lys His Asp Ser Ser Trp Val Glu Glu 
865                 870                 875                 880 


Leu Leu Met Leu His Arg Ala Arg Ile Thr Asp Val Glu His Ile Thr 
                885                 890                 895     


Gly Leu Ser Phe Tyr Gln Gln Arg Lys Glu Pro Val Ser Asp Ile Leu 
            900                 905                 910         


Lys Leu Lys Thr His Leu Pro Thr Phe Ser Gln Glu Asp Arg Ser Gly 
        915                 920                 925             


Ser Gly Gly Ser Met Lys Trp Val Thr Phe Leu Leu Leu Leu Phe Val 
    930                 935                 940                 


Ser Gly Ser Ala Phe Ser Arg Gly Val Phe Arg Arg Glu Ala His Lys 
945                 950                 955                 960 


Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys 
                965                 970                 975     


Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr 
            980                 985                 990         


Asp Glu His Ala Lys Leu Val Gln  Glu Val Thr Asp Phe  Ala Lys Thr 
        995                 1000                 1005             


Cys Val  Ala Asp Glu Ser Ala  Ala Asn Cys Asp Lys  Ser Leu His 
    1010                 1015                 1020             


Thr Leu  Phe Gly Asp Lys Leu  Cys Ala Ile Pro Asn  Leu Arg Glu 
    1025                 1030                 1035             


Asn Tyr  Gly Glu Leu Ala Asp  Cys Cys Thr Lys Gln  Glu Pro Glu 
    1040                 1045                 1050             


Arg Asn  Glu Cys Phe Leu Gln  His Lys Asp Asp Asn  Pro Ser Leu 
    1055                 1060                 1065             


Pro Pro  Phe Glu Arg Pro Glu  Ala Glu Ala Met Cys  Thr Ser Phe 
    1070                 1075                 1080             


Lys Glu  Asn Pro Thr Thr Phe  Met Gly His Tyr Leu  His Glu Val 
    1085                 1090                 1095             


Ala Arg  Arg His Pro Tyr Phe  Tyr Ala Pro Glu Leu  Leu Tyr Tyr 
    1100                 1105                 1110             


Ala Glu  Gln Tyr Asn Glu Ile  Leu Thr Gln Cys Cys  Ala Glu Ala 
    1115                 1120                 1125             


Asp Lys  Glu Ser Cys Leu Thr  Pro Lys Leu Asp Gly  Val Lys Glu 
    1130                 1135                 1140             


Lys Ala  Leu Val Ser Ser Val  Arg Gln Arg Met Lys  Cys Ser Ser 
    1145                 1150                 1155             


Met Gln  Lys Phe Gly Glu Arg  Ala Phe Lys Ala Trp  Ala Val Ala 
    1160                 1165                 1170             


Arg Leu  Ser Gln Thr Phe Pro  Asn Ala Asp Phe Ala  Glu Ile Thr 
    1175                 1180                 1185             


Lys Leu  Ala Thr Asp Leu Thr  Lys Val Asn Lys Glu  Cys Cys His 
    1190                 1195                 1200             


Gly Asp  Leu Leu Glu Cys Ala  Asp Asp Arg Ala Glu  Leu Ala Lys 
    1205                 1210                 1215             


Tyr Met  Cys Glu Asn Gln Ala  Thr Ile Ser Ser Lys  Leu Gln Thr 
    1220                 1225                 1230             


Cys Cys  Asp Lys Pro Leu Leu  Lys Lys Ala His Cys  Leu Ser Glu 
    1235                 1240                 1245             


Val Glu  His Asp Thr Met Pro  Ala Asp Leu Pro Ala  Ile Ala Ala 
    1250                 1255                 1260             


Asp Phe  Val Glu Asp Gln Glu  Val Cys Lys Asn Tyr  Ala Glu Ala 
    1265                 1270                 1275             


Lys Asp  Val Phe Leu Gly Thr  Phe Leu Tyr Glu Tyr  Ser Arg Arg 
    1280                 1285                 1290             


His Pro  Asp Tyr Ser Val Ser  Leu Leu Leu Arg Leu  Ala Lys Lys 
    1295                 1300                 1305             


Tyr Glu  Ala Thr Leu Glu Lys  Cys Cys Ala Glu Ala  Asn Pro Pro 
    1310                 1315                 1320             


Ala Cys  Tyr Gly Thr Val Leu  Ala Glu Phe Gln Pro  Leu Val Glu 
    1325                 1330                 1335             


Glu Pro  Lys Asn Leu Val Lys  Thr Asn Cys Asp Leu  Tyr Glu Lys 
    1340                 1345                 1350             


Leu Gly  Glu Tyr Gly Phe Gln  Asn Ala Ile Leu Val  Arg Tyr Thr 
    1355                 1360                 1365             


Gln Lys  Ala Pro Gln Val Ser  Thr Pro Thr Leu Val  Glu Ala Ala 
    1370                 1375                 1380             


Arg Asn  Leu Gly Arg Val Gly  Thr Lys Cys Cys Thr  Leu Pro Glu 
    1385                 1390                 1395             


Asp Gln  Arg Leu Pro Cys Val  Glu Asp Tyr Leu Ser  Ala Ile Leu 
    1400                 1405                 1410             


Asn Arg  Val Cys Leu Leu His  Glu Lys Thr Pro Val  Ser Glu His 
    1415                 1420                 1425             


Val Thr  Lys Cys Cys Ser Gly  Ser Leu Val Glu Arg  Arg Pro Cys 
    1430                 1435                 1440             


Phe Ser  Ala Leu Thr Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe 
    1445                 1450                 1455             


Lys Ala  Glu Thr Phe Thr Phe  His Ser Asp Ile Cys  Thr Leu Pro 
    1460                 1465                 1470             


Glu Lys  Glu Lys Gln Ile Lys  Lys Gln Thr Ala Leu  Ala Glu Leu 
    1475                 1480                 1485             


Val Lys  His Lys Pro Lys Ala  Thr Ala Glu Gln Leu  Lys Thr Val 
    1490                 1495                 1500             


Met Asp  Asp Phe Ala Gln Phe  Leu Asp Thr Cys Cys  Lys Ala Ala 
    1505                 1510                 1515             


Asp Lys  Asp Thr Cys Phe Ser  Thr Glu Gly Pro Asn  Leu Val Thr 
    1520                 1525                 1530             


Arg Cys  Lys Asp Ala Leu Ala  Arg Ser Trp Ser His  Pro Gln Phe 
    1535                 1540                 1545             


Glu Lys  
    1550 


<210>  30
<211>  1147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP121-NPP3-Fc sequence


<220>
<221>  SIGNAL
<222>  (95)..(96)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (921)..(1147)

<400>  30

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Ile Ile Ser Leu 
65                  70                  75                  80  


Phe Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala Lys 
                85                  90                  95      


Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg Gly Leu 
            100                 105                 110         


Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp Cys Cys 
        115                 120                 125             


Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp Met Cys 
    130                 135                 140                 


Asn Lys Phe Arg Cys Gly Glu Arg Leu Glu Ala Ser Leu Cys Ser Cys 
145                 150                 155                 160 


Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Ala Asp Tyr Lys Ser 
                165                 170                 175     


Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys Asp Thr Ala 
            180                 185                 190         


Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro Val Ile Leu 
        195                 200                 205             


Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr Trp Asp Thr 
    210                 215                 220                 


Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile His Ser Lys 
225                 230                 235                 240 


Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Thr 
                245                 250                 255     


Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Asn 
            260                 265                 270         


Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser Ser Lys Glu 
        275                 280                 285             


Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp Leu Thr Ala 
    290                 295                 300                 


Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro Gly Ser Glu 
305                 310                 315                 320 


Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro Tyr Asn Gly 
                325                 330                 335     


Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys Trp Leu Asp 
            340                 345                 350         


Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr Phe Glu Glu 
        355                 360                 365             


Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala Arg Val Ile 
    370                 375                 380                 


Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu Met Glu Gly 
385                 390                 395                 400 


Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile Leu Leu Ala 
                405                 410                 415     


Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu Tyr Met Thr 
            420                 425                 430         


Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu Gly Pro Ala 
        435                 440                 445             


Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe Ser Phe Asn 
    450                 455                 460                 


Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro Asp Gln His 
465                 470                 475                 480 


Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu His Tyr Ala 
                485                 490                 495     


Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp Gln Gln Trp 
            500                 505                 510         


Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly Gly Asn His 
        515                 520                 525             


Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe Leu Ala His 
    530                 535                 540                 


Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe Glu Asn Ile 
545                 550                 555                 560 


Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln Pro Ala Pro 
                565                 570                 575     


Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys Val Pro Phe 
            580                 585                 590         


Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser Val Cys Gly 
        595                 600                 605             


Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe Cys Pro His 
    610                 615                 620                 


Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met Leu Asn Leu 
625                 630                 635                 640 


Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu Pro Phe Gly 
                645                 650                 655     


Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu Leu Tyr His 
            660                 665                 670         


Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met Pro Met Trp 
        675                 680                 685             


Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro Leu Pro Pro 
    690                 695                 700                 


Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro Pro Ser Glu 
705                 710                 715                 720 


Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile Thr His Gly 
                725                 730                 735     


Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser Gln Tyr Asp 
            740                 745                 750         


Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu Phe Arg Lys 
        755                 760                 765             


Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His Ala Thr Glu 
    770                 775                 780                 


Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp Tyr Asn Tyr 
785                 790                 795                 800 


Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His Leu Ala Asn 
                805                 810                 815     


Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu Thr Ser Cys 
            820                 825                 830         


Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp Leu Asp Val 
        835                 840                 845             


Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu Ser Cys Pro 
    850                 855                 860                 


Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe Thr Ala His 
865                 870                 875                 880 


Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu Asp Phe Tyr 
                885                 890                 895     


Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu Lys Thr Tyr 
            900                 905                 910         


Leu Pro Thr Phe Glu Thr Thr Ile Asp Lys Thr His Thr Cys Pro Pro 
        915                 920                 925             


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    930                 935                 940                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
945                 950                 955                 960 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                965                 970                 975     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            980                 985                 990         


Glu Glu Gln Tyr Asn Ser Thr Tyr  Arg Val Val Ser Val  Leu Thr Val 
        995                 1000                 1005             


Leu His  Gln Asp Trp Leu Asn  Gly Lys Glu Tyr Lys  Cys Lys Val 
    1010                 1015                 1020             


Ser Asn  Lys Ala Leu Pro Ala  Pro Ile Glu Lys Thr  Ile Ser Lys 
    1025                 1030                 1035             


Ala Lys  Gly Gln Pro Arg Glu  Pro Gln Val Tyr Thr  Leu Pro Pro 
    1040                 1045                 1050             


Ser Arg  Glu Glu Met Thr Lys  Asn Gln Val Ser Leu  Thr Cys Leu 
    1055                 1060                 1065             


Val Lys  Gly Phe Tyr Pro Ser  Asp Ile Ala Val Glu  Trp Glu Ser 
    1070                 1075                 1080             


Asn Gly  Gln Pro Glu Asn Asn  Tyr Lys Thr Thr Pro  Pro Val Leu 
    1085                 1090                 1095             


Asp Ser  Asp Gly Ser Phe Phe  Leu Tyr Ser Lys Leu  Thr Val Asp 
    1100                 1105                 1110             


Lys Ser  Arg Trp Gln Gln Gly  Asn Val Phe Ser Cys  Ser Val Met 
    1115                 1120                 1125             


His Glu  Ala Leu His Asn His  Tyr Thr Gln Lys Ser  Leu Ser Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys 
    1145         


<210>  31
<211>  1542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP121-NPP3-Albumin sequence


<220>
<221>  SIGNAL
<222>  (95)..(96)
<223>  Cleavage point of the signal peptide sequence

<220>
<221>  MISC_FEATURE
<222>  (935)..(1542)
<223>  Indicate Albumin sequence

<400>  31

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Ile Ile Ser Leu 
65                  70                  75                  80  


Phe Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala Lys 
                85                  90                  95      


Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg Gly Leu 
            100                 105                 110         


Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp Cys Cys 
        115                 120                 125             


Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp Met Cys 
    130                 135                 140                 


Asn Lys Phe Arg Cys Gly Glu Arg Leu Glu Ala Ser Leu Cys Ser Cys 
145                 150                 155                 160 


Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Ala Asp Tyr Lys Ser 
                165                 170                 175     


Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys Asp Thr Ala 
            180                 185                 190         


Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro Val Ile Leu 
        195                 200                 205             


Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr Trp Asp Thr 
    210                 215                 220                 


Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile His Ser Lys 
225                 230                 235                 240 


Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn His Tyr Thr 
                245                 250                 255     


Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile Asp Asn Asn 
            260                 265                 270         


Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser Ser Lys Glu 
        275                 280                 285             


Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp Leu Thr Ala 
    290                 295                 300                 


Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro Gly Ser Glu 
305                 310                 315                 320 


Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro Tyr Asn Gly 
                325                 330                 335     


Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys Trp Leu Asp 
            340                 345                 350         


Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr Phe Glu Glu 
        355                 360                 365             


Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala Arg Val Ile 
    370                 375                 380                 


Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu Met Glu Gly 
385                 390                 395                 400 


Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile Leu Leu Ala 
                405                 410                 415     


Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu Tyr Met Thr 
            420                 425                 430         


Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu Gly Pro Ala 
        435                 440                 445             


Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe Ser Phe Asn 
    450                 455                 460                 


Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro Asp Gln His 
465                 470                 475                 480 


Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu His Tyr Ala 
                485                 490                 495     


Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp Gln Gln Trp 
            500                 505                 510         


Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly Gly Asn His 
        515                 520                 525             


Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe Leu Ala His 
    530                 535                 540                 


Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe Glu Asn Ile 
545                 550                 555                 560 


Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln Pro Ala Pro 
                565                 570                 575     


Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys Val Pro Phe 
            580                 585                 590         


Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser Val Cys Gly 
        595                 600                 605             


Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe Cys Pro His 
    610                 615                 620                 


Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met Leu Asn Leu 
625                 630                 635                 640 


Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu Pro Phe Gly 
                645                 650                 655     


Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu Leu Tyr His 
            660                 665                 670         


Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met Pro Met Trp 
        675                 680                 685             


Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro Leu Pro Pro 
    690                 695                 700                 


Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro Pro Ser Glu 
705                 710                 715                 720 


Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile Thr His Gly 
                725                 730                 735     


Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser Gln Tyr Asp 
            740                 745                 750         


Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu Phe Arg Lys 
        755                 760                 765             


Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His Ala Thr Glu 
    770                 775                 780                 


Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp Tyr Asn Tyr 
785                 790                 795                 800 


Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His Leu Ala Asn 
                805                 810                 815     


Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu Thr Ser Cys 
            820                 825                 830         


Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp Leu Asp Val 
        835                 840                 845             


Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu Ser Cys Pro 
    850                 855                 860                 


Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe Thr Ala His 
865                 870                 875                 880 


Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu Asp Phe Tyr 
                885                 890                 895     


Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu Lys Thr Tyr 
            900                 905                 910         


Leu Pro Thr Phe Glu Thr Thr Ile Gly Gly Gly Ser Gly Gly Gly Gly 
        915                 920                 925             


Ser Gly Gly Gly Gly Ser Met Lys Trp Val Thr Phe Leu Leu Leu Leu 
    930                 935                 940                 


Phe Val Ser Gly Ser Ala Phe Ser Arg Gly Val Phe Arg Arg Glu Ala 
945                 950                 955                 960 


His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly Glu Gln His 
                965                 970                 975     


Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys 
            980                 985                 990         


Ser Tyr Asp Glu His Ala Lys Leu  Val Gln Glu Val Thr  Asp Phe Ala 
        995                 1000                 1005             


Lys Thr  Cys Val Ala Asp Glu  Ser Ala Ala Asn Cys  Asp Lys Ser 
    1010                 1015                 1020             


Leu His  Thr Leu Phe Gly Asp  Lys Leu Cys Ala Ile  Pro Asn Leu 
    1025                 1030                 1035             


Arg Glu  Asn Tyr Gly Glu Leu  Ala Asp Cys Cys Thr  Lys Gln Glu 
    1040                 1045                 1050             


Pro Glu  Arg Asn Glu Cys Phe  Leu Gln His Lys Asp  Asp Asn Pro 
    1055                 1060                 1065             


Ser Leu  Pro Pro Phe Glu Arg  Pro Glu Ala Glu Ala  Met Cys Thr 
    1070                 1075                 1080             


Ser Phe  Lys Glu Asn Pro Thr  Thr Phe Met Gly His  Tyr Leu His 
    1085                 1090                 1095             


Glu Val  Ala Arg Arg His Pro  Tyr Phe Tyr Ala Pro  Glu Leu Leu 
    1100                 1105                 1110             


Tyr Tyr  Ala Glu Gln Tyr Asn  Glu Ile Leu Thr Gln  Cys Cys Ala 
    1115                 1120                 1125             


Glu Ala  Asp Lys Glu Ser Cys  Leu Thr Pro Lys Leu  Asp Gly Val 
    1130                 1135                 1140             


Lys Glu  Lys Ala Leu Val Ser  Ser Val Arg Gln Arg  Met Lys Cys 
    1145                 1150                 1155             


Ser Ser  Met Gln Lys Phe Gly  Glu Arg Ala Phe Lys  Ala Trp Ala 
    1160                 1165                 1170             


Val Ala  Arg Leu Ser Gln Thr  Phe Pro Asn Ala Asp  Phe Ala Glu 
    1175                 1180                 1185             


Ile Thr  Lys Leu Ala Thr Asp  Leu Thr Lys Val Asn  Lys Glu Cys 
    1190                 1195                 1200             


Cys His  Gly Asp Leu Leu Glu  Cys Ala Asp Asp Arg  Ala Glu Leu 
    1205                 1210                 1215             


Ala Lys  Tyr Met Cys Glu Asn  Gln Ala Thr Ile Ser  Ser Lys Leu 
    1220                 1225                 1230             


Gln Thr  Cys Cys Asp Lys Pro  Leu Leu Lys Lys Ala  His Cys Leu 
    1235                 1240                 1245             


Ser Glu  Val Glu His Asp Thr  Met Pro Ala Asp Leu  Pro Ala Ile 
    1250                 1255                 1260             


Ala Ala  Asp Phe Val Glu Asp  Gln Glu Val Cys Lys  Asn Tyr Ala 
    1265                 1270                 1275             


Glu Ala  Lys Asp Val Phe Leu  Gly Thr Phe Leu Tyr  Glu Tyr Ser 
    1280                 1285                 1290             


Arg Arg  His Pro Asp Tyr Ser  Val Ser Leu Leu Leu  Arg Leu Ala 
    1295                 1300                 1305             


Lys Lys  Tyr Glu Ala Thr Leu  Glu Lys Cys Cys Ala  Glu Ala Asn 
    1310                 1315                 1320             


Pro Pro  Ala Cys Tyr Gly Thr  Val Leu Ala Glu Phe  Gln Pro Leu 
    1325                 1330                 1335             


Val Glu  Glu Pro Lys Asn Leu  Val Lys Thr Asn Cys  Asp Leu Tyr 
    1340                 1345                 1350             


Glu Lys  Leu Gly Glu Tyr Gly  Phe Gln Asn Ala Ile  Leu Val Arg 
    1355                 1360                 1365             


Tyr Thr  Gln Lys Ala Pro Gln  Val Ser Thr Pro Thr  Leu Val Glu 
    1370                 1375                 1380             


Ala Ala  Arg Asn Leu Gly Arg  Val Gly Thr Lys Cys  Cys Thr Leu 
    1385                 1390                 1395             


Pro Glu  Asp Gln Arg Leu Pro  Cys Val Glu Asp Tyr  Leu Ser Ala 
    1400                 1405                 1410             


Ile Leu  Asn Arg Val Cys Leu  Leu His Glu Lys Thr  Pro Val Ser 
    1415                 1420                 1425             


Glu His  Val Thr Lys Cys Cys  Ser Gly Ser Leu Val  Glu Arg Arg 
    1430                 1435                 1440             


Pro Cys  Phe Ser Ala Leu Thr  Val Asp Glu Thr Tyr  Val Pro Lys 
    1445                 1450                 1455             


Glu Phe  Lys Ala Glu Thr Phe  Thr Phe His Ser Asp  Ile Cys Thr 
    1460                 1465                 1470             


Leu Pro  Glu Lys Glu Lys Gln  Ile Lys Lys Gln Thr  Ala Leu Ala 
    1475                 1480                 1485             


Glu Leu  Val Lys His Lys Pro  Lys Ala Thr Ala Glu  Gln Leu Lys 
    1490                 1495                 1500             


Thr Val  Met Asp Asp Phe Ala  Gln Phe Leu Asp Thr  Cys Cys Lys 
    1505                 1510                 1515             


Ala Ala  Asp Lys Asp Thr Cys  Phe Ser Thr Glu Gly  Pro Asn Leu 
    1520                 1525                 1530             


Val Thr  Arg Cys Lys Asp Ala  Leu Ala 
    1535                 1540         


<210>  32
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP121GLK Protein Export Signal Sequence

<400>  32

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Ile Ile Ser Leu 
65                  70                  75                  80  


Phe Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala Gly 
                85                  90                  95      


Leu Lys 
        


<210>  33
<211>  623
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin Sequence

<400>  33

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
1               5                   10                  15      


Lys Trp Val Thr Phe Leu Leu Leu Leu Phe Val Ser Gly Ser Ala Phe 
            20                  25                  30          


Ser Arg Gly Val Phe Arg Arg Glu Ala His Lys Ser Glu Ile Ala His 
        35                  40                  45              


Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile 
    50                  55                  60                  


Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys 
65                  70                  75                  80  


Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu 
                85                  90                  95      


Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
            100                 105                 110         


Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp 
        115                 120                 125             


Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
    130                 135                 140                 


Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala Glu 
145                 150                 155                 160 


Ala Met Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met Gly His 
                165                 170                 175     


Tyr Leu His Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
            180                 185                 190         


Leu Leu Tyr Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys Cys 
        195                 200                 205             


Ala Glu Ala Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly Val 
    210                 215                 220                 


Lys Glu Lys Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys Cys Ser 
225                 230                 235                 240 


Ser Met Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
                245                 250                 255     


Arg Leu Ser Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr Lys 
            260                 265                 270         


Leu Ala Thr Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His Gly Asp 
        275                 280                 285             


Leu Leu Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met Cys 
    290                 295                 300                 


Glu Asn Gln Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp Lys 
305                 310                 315                 320 


Pro Leu Leu Lys Lys Ala His Cys Leu Ser Glu Val Glu His Asp Thr 
                325                 330                 335     


Met Pro Ala Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu Asp Gln 
            340                 345                 350         


Glu Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Thr 
        355                 360                 365             


Phe Leu Tyr Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser Leu 
    370                 375                 380                 


Leu Leu Arg Leu Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys Cys 
385                 390                 395                 400 


Ala Glu Ala Asn Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu Phe 
                405                 410                 415     


Gln Pro Leu Val Glu Glu Pro Lys Asn Leu Val Lys Thr Asn Cys Asp 
            420                 425                 430         


Leu Tyr Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu Val 
        435                 440                 445             


Arg Tyr Thr Gln Lys Ala Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
    450                 455                 460                 


Ala Ala Arg Asn Leu Gly Arg Val Gly Thr Lys Cys Cys Thr Leu Pro 
465                 470                 475                 480 


Glu Asp Gln Arg Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile Leu 
                485                 490                 495     


Asn Arg Val Cys Leu Leu His Glu Lys Thr Pro Val Ser Glu His Val 
            500                 505                 510         


Thr Lys Cys Cys Ser Gly Ser Leu Val Glu Arg Arg Pro Cys Phe Ser 
        515                 520                 525             


Ala Leu Thr Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala Glu 
    530                 535                 540                 


Thr Phe Thr Phe His Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu Lys 
545                 550                 555                 560 


Gln Ile Lys Lys Gln Thr Ala Leu Ala Glu Leu Val Lys His Lys Pro 
                565                 570                 575     


Lys Ala Thr Ala Glu Gln Leu Lys Thr Val Met Asp Asp Phe Ala Gln 
            580                 585                 590         


Phe Leu Asp Thr Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe Ser 
        595                 600                 605             


Thr Glu Gly Pro Asn Leu Val Thr Arg Cys Lys Asp Ala Leu Ala 
    610                 615                 620             


<210>  34
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG Fc domain, Fc

<400>  34

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  35
<211>  618
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin Sequence

<400>  35

Met Lys Trp Val Thr Phe Leu Leu Leu Leu Phe Val Ser Gly Ser Ala 
1               5                   10                  15      


Phe Ser Arg Gly Val Phe Arg Arg Glu Ala His Lys Ser Glu Ile Ala 
            20                  25                  30          


His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala 
    50                  55                  60                  


Lys Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala 
            100                 105                 110         


Asp Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala 
    130                 135                 140                 


Glu Ala Met Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met Gly 
145                 150                 155                 160 


His Tyr Leu His Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys 
            180                 185                 190         


Cys Ala Glu Ala Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly 
        195                 200                 205             


Val Lys Glu Lys Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys Cys 
    210                 215                 220                 


Ser Ser Met Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr 
                245                 250                 255     


Lys Leu Ala Thr Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met 
        275                 280                 285             


Cys Glu Asn Gln Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp 
    290                 295                 300                 


Lys Pro Leu Leu Lys Lys Ala His Cys Leu Ser Glu Val Glu His Asp 
305                 310                 315                 320 


Thr Met Pro Ala Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu Asp 
                325                 330                 335     


Gln Glu Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Thr Phe Leu Tyr Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Glu Ala Asn Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu 
385                 390                 395                 400 


Phe Gln Pro Leu Val Glu Glu Pro Lys Asn Leu Val Lys Thr Asn Cys 
                405                 410                 415     


Asp Leu Tyr Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu 
            420                 425                 430         


Val Arg Tyr Thr Gln Lys Ala Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Ala Ala Arg Asn Leu Gly Arg Val Gly Thr Lys Cys Cys Thr Leu 
    450                 455                 460                 


Pro Glu Asp Gln Arg Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile 
465                 470                 475                 480 


Leu Asn Arg Val Cys Leu Leu His Glu Lys Thr Pro Val Ser Glu His 
                485                 490                 495     


Val Thr Lys Cys Cys Ser Gly Ser Leu Val Glu Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Thr Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu 
    530                 535                 540                 


Lys Gln Ile Lys Lys Gln Thr Ala Leu Ala Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Ala Glu Gln Leu Lys Thr Val Met Asp Asp Phe Ala 
                565                 570                 575     


Gln Phe Leu Asp Thr Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe 
            580                 585                 590         


Ser Thr Glu Gly Pro Asn Leu Val Thr Arg Cys Lys Asp Ala Leu Ala 
        595                 600                 605             


Arg Ser Trp Ser His Pro Gln Phe Glu Lys 
    610                 615             


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ENPP2 Signal Peptide

<400>  36

Leu Phe Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala 
1               5                   10                  15      


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence ENPP7

<400>  37

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala 
            20  


<210>  38
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence ENPP7

<400>  38

Met Arg Gly Pro Ala Val Leu Leu Thr Val Ala Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ala Pro Gly Ala Gly Ala 
            20          


<210>  39
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence ENPP1-2-1

<400>  39

Met Glu Arg Asp Gly Cys Ala Gly Gly Gly Ser Arg Gly Gly Glu Gly 
1               5                   10                  15      


Gly Arg Ala Pro Arg Glu Gly Pro Ala Gly Asn Gly Arg Asp Arg Gly 
            20                  25                  30          


Arg Ser His Ala Ala Glu Ala Pro Gly Asp Pro Gln Ala Ala Ala Ser 
        35                  40                  45              


Leu Leu Ala Pro Met Asp Val Gly Glu Glu Pro Leu Glu Lys Ala Ala 
    50                  55                  60                  


Arg Ala Arg Thr Ala Lys Asp Pro Asn Thr Tyr Lys Ile Ile Ser Leu 
65                  70                  75                  80  


Phe Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala 
                85                  90                  95  


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exENPP3

<400>  40

Leu Leu Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg 
1               5                   10                  15      


Lys 
    


<210>  41
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence ENPP5

<400>  41

Met Thr Ser Lys Phe Leu Leu Val Ser Phe Ile Leu Ala Ala Leu Ser 
1               5                   10                  15      


Leu Ser Thr Thr Phe Ser 
            20          


<210>  42
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence - Azurocidin

<400>  42

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala 
            


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<223>  Features section of the listing that any one or all of amino 
       acids 1-15 can either be present or absent

<400>  43

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10                  15  


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  44

Asp Ser Ser Ser Glu Glu Lys Phe Leu Arg Arg Ile Gly Arg Phe Gly 
1               5                   10                  15      


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  45

Glu Glu Glu Glu Glu Glu Glu Pro Arg Gly Asp Thr 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  46

Ala Pro Trp His Leu Ser Ser Gln Tyr Ser Arg Thr 
1               5                   10          


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  47

Ser Thr Leu Pro Ile Pro His Glu Phe Ser Arg Glu 
1               5                   10          


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  48

Val Thr Lys His Leu Asn Gln Ile Ser Gln Ser Tyr 
1               5                   10          


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<223>  Features section of the listing that any one or all of amino 
       acids 2-15 can either be present or absent

<400>  49

Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
1               5                   10                  15  


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  50

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  51

Arg Ser Gly Ser Gly Gly Ser 
1               5           


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<223>  Features section of the listing that any one or all of amino 
       acids 2-15 can either be present or absent

<400>  52

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
1               5                   10                  15  


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  53

Leu Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10                  15      


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  54

Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10                  15  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  55

Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10                  


<210>  56
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  56

Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10              


<210>  57
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  57

Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10          


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  58

Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10      


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  59

Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   10  


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  60

Leu Gly Leu Gly Leu Gly Leu Arg Lys 
1               5                   


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  61

Gly Leu Gly Leu Gly Leu Arg Lys 
1               5               


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  62

Leu Gly Leu Gly Leu Arg Lys 
1               5           


<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  63

Gly Leu Gly Leu Arg Lys 
1               5       


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  64

Leu Gly Leu Arg Lys 
1               5   


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  65

Gly Leu Arg Lys 
1               


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<223>  Features section of the listing that any one or all of amino 
       acids 1-15 can either be present or absent

<400>  66

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<223>  Features section of the listing that any one or all of amino 
       acids 2-15 can either be present or absent

<400>  67

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp 
1               5                   10                  15  


<210>  68
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  MISC_FEATURE
<223>  Amino acids 6-50 can either be present or absent in groups of 
       5(GGGGS) starting at position 6

<400>  68

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210>  69
<211>  2625
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ENPP3 Nucleotide sequence

<400>  69
atggaatcta cgttgacttt agcaacggaa caacctgtta agaagaacac tcttaagaaa       60

tataaaatag cttgcattgt tcttcttgct ttgctggtga tcatgtcact tggattaggc      120

ctggggcttg gactcaggaa actggaaaag caaggcagct gcaggaagaa gtgctttgat      180

gcatcattta gaggactgga gaactgccgg tgtgatgtgg catgtaaaga ccgaggtgat      240

tgctgctggg attttgaaga cacctgtgtg gaatcaactc gaatatggat gtgcaataaa      300

tttcgttgtg gagagaccag attagaggcc agcctttgct cttgttcaga tgactgtttg      360

cagaggaaag attgctgtgc tgactataag agtgtttgcc aaggagaaac ctcatggctg      420

gaagaaaact gtgacacagc ccagcagtct cagtgcccag aagggtttga cctgccacca      480

gttatcttgt tttctatgga tggatttaga gctgaatatt tatacacatg ggatacttta      540

atgccaaata tcaataaact gaaaacatgt ggaattcatt caaaatacat gagagctatg      600

tatcctacca aaaccttccc aaatcattac accattgtca cgggcttgta tccagagtca      660

catggcatca ttgacaataa tatgtatgat gtaaatctca acaagaattt ttcactttct      720

tcaaaggaac aaaataatcc agcctggtgg catgggcaac caatgtggct gacagcaatg      780

tatcaaggtt taaaagccgc tacctacttt tggcccggat cagaagtggc tataaatggc      840

tcctttcctt ccatatacat gccttacaac ggaagtgtcc catttgaaga gaggatttct      900

acactgttaa aatggctgga cctgcccaaa gctgaaagac ccaggtttta taccatgtat      960

tttgaagaac ctgattcctc tggacatgca ggtggaccag tcagtgccag agtaattaaa     1020

gccttacagg tagtagatca tgcttttggg atgttgatgg aaggcctgaa gcagcggaat     1080

ttgcacaact gtgtcaatat catccttctg gctgaccatg gaatggacca gacttattgt     1140

aacaagatgg aatacatgac tgattatttt cccagaataa acttcttcta catgtacgaa     1200

gggcctgccc cccgcatccg agctcataat atacctcatg acttttttag ttttaattct     1260

gaggaaattg ttagaaacct cagttgccga aaacctgatc agcatttcaa gccctatttg     1320

actcctgatt tgccaaagcg actgcactat gccaagaacg tcagaatcga caaagttcat     1380

ctctttgtgg atcaacagtg gctggctgtt aggagtaaat caaatacaaa ttgtggagga     1440

ggcaaccatg gttataacaa tgagtttagg agcatggagg ctatctttct ggcacatgga     1500

cccagtttta aagagaagac tgaagttgaa ccatttgaaa atattgaagt ctataaccta     1560

atgtgtgatc ttctacgcat tcaaccagca ccaaacaatg gaacccatgg tagtttaaac     1620

catcttctga aggtgccttt ttatgagcca tcccatgcag aggaggtgtc aaagttttct     1680

gtttgtggct ttgctaatcc attgcccaca gagtctcttg actgtttctg ccctcaccta     1740

caaaatagta ctcagctgga acaagtgaat cagatgctaa atctcaccca agaagaaata     1800

acagcaacag tgaaagtaaa tttgccattt gggaggccta gggtactgca gaagaacgtg     1860

gaccactgtc tcctttacca cagggaatat gtcagtggat ttggaaaagc tatgaggatg     1920

cccatgtgga gttcatacac agtcccccag ttgggagaca catcgcctct gcctcccact     1980

gtcccagact gtctgcgggc tgatgtcagg gttcctcctt ctgagagcca aaaatgttcc     2040

ttctatttag cagacaagaa tatcacccac ggcttcctct atcctcctgc cagcaataga     2100

acatcagata gccaatatga tgctttaatt actagcaatt tggtacctat gtatgaagaa     2160

ttcagaaaaa tgtgggacta cttccacagt gttcttctta taaaacatgc cacagaaaga     2220

aatggagtaa atgtggttag tggaccaata tttgattata attatgatgg ccattttgat     2280

gctccagatg aaattaccaa acatttagcc aacactgatg ttcccatccc aacacactac     2340

tttgtggtgc tgaccagttg taaaaacaag agccacacac cggaaaactg ccctgggtgg     2400

ctggatgtcc taccctttat catccctcac cgacctacca acgtggagag ctgtcctgaa     2460

ggtaaaccag aagctctttg ggttgaagaa agatttacag ctcacattgc ccgggtccgt     2520

gatgtagaac ttctcactgg gcttgacttc tatcaggata aagtgcagcc tgtctctgaa     2580

attttgcaac taaagacata tttaccaaca tttgaaacca ctatt                     2625


<210>  70
<211>  2775
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ENPP1 Nucleotide sequence

<400>  70
atggaacggg acggctgtgc cggcggagga tcaagaggcg gagaaggcgg cagagcccct       60

agagaaggac ctgccggcaa cggcagagac agaggcagat ctcatgccgc cgaagcccct      120

ggcgatcctc aggctgctgc ttctctgctg gcccccatgg atgtgggcga ggaacctctg      180

gaaaaggccg ccagagccag aaccgccaag gaccccaaca cctacaaggt gctgagcctg      240

gtgctgtccg tgtgcgtgct gaccaccatc ctgggctgca tcttcggcct gaagcccagc      300

tgcgccaaag aagtgaagtc ctgcaagggc cggtgcttcg agcggacctt cggcaactgc      360

agatgcgacg ccgcctgtgt ggaactgggc aactgctgcc tggactacca ggaaacctgc      420

atcgagcccg agcacatctg gacctgcaac aagttcagat gcggcgagaa gcggctgacc      480

agatccctgt gtgcctgcag cgacgactgc aaggacaagg gcgactgctg catcaactac      540

agcagcgtgt gccagggcga gaagtcctgg gtggaagaac cctgcgagag catcaacgag      600

ccccagtgcc ctgccggctt cgagacacct cctaccctgc tgttcagcct ggacggcttt      660

cgggccgagt acctgcacac atggggaggc ctgctgcccg tgatcagcaa gctgaagaag      720

tgcggcacct acaccaagaa catgcggccc gtgtacccca ccaagacctt ccccaaccac      780

tactccatcg tgaccggcct gtaccccgag agccacggca tcatcgacaa caagatgtac      840

gaccccaaga tgaacgccag cttcagcctg aagtccaaag agaagttcaa ccccgagtgg      900

tataagggcg agcccatctg ggtcaccgcc aagtaccagg gcctgaaaag cggcacattc      960

ttttggcccg gcagcgacgt ggaaatcaac ggcatcttcc ccgacatcta taagatgtac     1020

aacggcagcg tgcccttcga ggaacggatc ctggctgtgc tgcagtggct gcagctgccc     1080

aaggatgagc ggccccactt ctacaccctg tacctggaag aacctgacag cagcggccac     1140

agctacggcc ctgtgtccag cgaagtgatc aaggccctgc agcgggtgga cggcatggtg     1200

ggaatgctga tggacggcct gaaagagctg aacctgcaca gatgcctgaa cctgatcctg     1260

atcagcgacc acggcatgga acagggatcc tgcaagaagt acatctacct gaacaagtac     1320

ctgggcgacg tgaagaacat caaagtgatc tacggcccag ccgccagact gaggcctagc     1380

gacgtgcccg acaagtacta cagcttcaac tacgagggaa tcgcccggaa cctgagctgc     1440

agagagccca accagcactt caagccctac ctgaagcact tcctgcccaa gcggctgcac     1500

ttcgccaaga gcgacagaat cgagcccctg accttctacc tggaccccca gtggcagctg     1560

gccctgaatc ccagcgagag aaagtactgc ggcagcggct tccacggctc cgacaacgtg     1620

ttcagcaaca tgcaggccct gttcgtgggc tacggacccg gctttaagca cggcatcgag     1680

gccgacacct tcgagaacat cgaggtgtac aatctgatgt gcgacctgct gaatctgacc     1740

cctgccccca acaatggcac ccacggcagc ctgaaccatc tgctgaagaa ccccgtgtac     1800

acccctaagc accccaaaga ggtgcacccc ctggtgcagt gccccttcac cagaaacccc     1860

agagacaacc tgggctgtag ctgcaacccc agcatcctgc ccatcgagga cttccagacc     1920

cagttcaacc tgaccgtggc cgaggaaaag atcatcaagc acgagacact gccctacggc     1980

agaccccggg tgctgcagaa agagaacacc atctgcctgc tgagccagca ccagttcatg     2040

agcggctact cccaggacat cctgatgccc ctgtggacca gctacaccgt ggaccggaac     2100

gacagcttct ccaccgagga tttcagcaac tgcctgtacc aggatttccg gatccccctg     2160

agccccgtgc acaagtgcag cttctacaag aacaacacca aggtgtccta cggcttcctg     2220

agccctcccc agctgaacaa gaacagctcc ggcatctaca gcgaggccct gctgactacc     2280

aacatcgtgc ccatgtacca gagcttccaa gtgatctggc ggtacttcca cgacaccctg     2340

ctgcggaagt acgccgaaga acggaacggc gtgaacgtgg tgtccggccc agtgttcgac     2400

ttcgactacg acggcagatg tgacagcctg gaaaatctgc ggcagaaaag aagagtgatc     2460

cggaaccagg aaattctgat ccctacccac ttctttatcg tgctgacaag ctgcaaggat     2520

accagccaga cccccctgca ctgcgagaac ctggataccc tggccttcat cctgcctcac     2580

cggaccgaca acagcgagag ctgtgtgcac ggcaagcacg acagctcttg ggtggaagaa     2640

ctgctgatgc tgcaccgggc cagaatcacc gatgtggaac acatcaccgg cctgagcttt     2700

taccagcagc ggaaagaacc cgtgtccgat atcctgaagc tgaaaaccca tctgcccacc     2760

ttcagccagg aagat                                                      2775


<210>  71
<211>  3255
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Azurocidin-ENPP1-FC Nucleotide sequence

<400>  71
ggtaccgcca ccatgacaag actgacagtg ctggctctgc tggccggact gttggcctct       60

tctagagctg ctccttcctg cgccaaagaa gtgaagtcct gcaagggcag atgcttcgag      120

cggaccttcg gcaactgtag atgtgacgcc gcttgcgtgg aactgggcaa ctgctgcctg      180

gactaccaag agacatgcat cgagcccgag cacatctgga cctgcaacaa gttcagatgc      240

ggcgagaagc ggctgaccag atctctgtgc gcctgctctg acgactgcaa ggacaagggc      300

gactgctgca tcaactactc ctctgtgtgc cagggcgaga agtcctgggt tgaagaaccc      360

tgcgagtcca tcaacgagcc tcagtgtcct gccggcttcg agacacctcc tactctgctg      420

ttctccctgg atggcttcag agccgagtac ctgcatactt ggggaggcct gctgccagtg      480

atctccaagc tgaagaagtg cggcacctac accaagaaca tgaggcctgt gtaccctacc      540

aagacattcc ccaaccacta ctccatcgtg accggcctgt atcctgagag ccacggcatc      600

atcgacaaca agatgtacga ccccaagatg aacgcctcct tcagcctgaa gtccaaagag      660

aagttcaacc ccgagtggta taagggcgag cctatctggg tcaccgctaa gtaccaggga      720

ctgaagtctg gcaccttctt ttggcctggc tccgacgtgg aaatcaacgg catcttcccc      780

gacatctata agatgtacaa cggctccgtg cctttcgagg aacgcattct ggctgttctg      840

cagtggctgc agctgcctaa ggatgagagg cctcacttct acaccctgta cctggaagaa      900

cctgactcct ccggccactc ttatggccct gtgtcctctg aagtgatcaa ggccctgcag      960

cgagtggacg gaatggtcgg aatgctgatg gacggcctga aagagctgaa cctgcacaga     1020

tgcctgaacc tgatcctgat ctccgaccac ggcatggaac aggggagctg caagaagtac     1080

atctacctga acaagtacct gggcgacgtg aagaacatca aagtgatcta cggcccagcc     1140

gccagactga ggccttctga tgtgcctgac aagtactact ccttcaacta cgagggaatc     1200

gcccggaacc tgtcctgcag agagcctaac cagcacttca agccctacct gaagcacttt     1260

ctgcctaagc ggctgcactt cgccaagtct gacagaatcg agcccctgac cttctatctg     1320

gaccctcagt ggcagctggc cctgaatcct agcgagagaa agtactgtgg ctccggcttc     1380

cacggctccg acaacgtgtt ctctaatatg caggccctgt tcgtcggcta cggccctggc     1440

tttaaacacg gcatcgaggc cgacaccttc gagaacatcg aggtgtacaa tctgatgtgt     1500

gacctgctga atctgacccc tgctcctaac aacggcaccc acggatctct gaaccatctg     1560

ctgaagaatc ccgtgtacac ccctaagcac cccaaagagg ttcaccctct ggtccagtgt     1620

cctttcacca gaaatcctcg ggacaacctg ggctgctctt gcaacccttc tatcctgcct     1680

atcgaggact ttcagaccca gttcaacctg accgtggccg aggaaaagat catcaagcac     1740

gagacactgc cctacggcag acctagagtg ctgcagaaag agaacaccat ctgcctgctg     1800

tcccagcacc agttcatgtc cggctactcc caggacatcc tgatgcctct gtggacctcc     1860

tacaccgtgg accggaacga tagcttctcc accgaggact tcagcaactg cctgtaccag     1920

gatttcagaa tccctctgag ccccgtgcac aagtgcagct tctacaagaa caacaccaag     1980

gtgtcctacg gcttcctgtc tcctccacag ctgaacaaga actccagcgg catctactct     2040

gaggccctgc tgaccaccaa catcgtgccc atgtaccagt ccttccaagt gatctggcgg     2100

tacttccacg acaccctgct gaggaagtac gccgaagaaa gaaacggcgt gaacgtggtg     2160

tctggccccg tgttcgactt cgactacgac ggcagatgcg actctctgga aaacctgcgg     2220

cagaaaagac gagtgatccg gaatcaagag atcctgattc ctacacactt ctttatcgtg     2280

ctgaccagct gcaaggatac ctctcagacc cctctgcact gcgagaatct ggacaccctg     2340

gccttcattc tgcctcacag aaccgacaac tccgagtcct gtgtgcacgg caagcacgac     2400

tcctcttggg tcgaagaact gctgatgctg caccgggcca gaatcaccga tgtggaacac     2460

atcaccggcc tgagcttcta ccagcagcgg aaagaacctg tgtccgatat cctgaagctg     2520

aaaacccatc tgccaacctt cagccaagag gacctgatca acgacaagac ccacacctgt     2580

cctccatgtc ctgctccaga actgctcgga ggcccctctg tgttcctgtt tccacctaag     2640

ccaaaggaca cactgatgat ctctcggacc cctgaagtga cctgcgtggt ggtggatgtg     2700

tctcacgaag atcccgaagt caagttcaat tggtacgtgg acggcgtgga agtgcacaac     2760

gccaagacca agcctagaga ggaacagtac aactccacct acagagtggt gtccgtgctg     2820

actgtgctgc accaggattg gctgaacggc aaagagtaca agtgcaaagt gtccaacaag     2880

gctctgcccg ctcctatcga aaagaccatc tccaaggcta agggccagcc tcgggaacct     2940

caggtttaca ccctgcctcc atctcgggaa gagatgacca agaaccaggt gtccctgacc     3000

tgcctggtca agggcttcta cccttccgat atcgccgtgg aatgggagtc caatggccag     3060

cctgagaaca actacaagac aacccctcct gtgctggaca gcgacggctc attcttcctg     3120

tactctaagc tgacagtgga caagtcccgg tggcagcaag gcaatgtgtt ttcctgctct     3180

gtgatgcacg aggccctcca caatcactac acccagaagt ccctgtctct gtcccctggc     3240

aaatgatagc tcgag                                                      3255


<210>  72
<211>  3219
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Azurocidin-ENPP3-FC Nucleotide sequence

<400>  72
atgaccagac tgaccgtgct ggccctgctg gccggcctgc tggccagcag cagagccgcc       60

aagcagggca gctgcagaaa gaagtgcttc gacgccagct tcagaggcct ggagaactgc      120

agatgcgacg tggcctgcaa ggacagaggc gactgctgct gggacttcga ggacacctgc      180

gtggagagca ccagaatctg gatgtgcaac aagttcagat gcggcgagac cagactggag      240

gccagcctgt gcagctgcag cgacgactgc ctgcagagaa aggactgctg cgccgactac      300

aagagcgtgt gccagggcga gaccagctgg ctggaggaga actgcgacac cgcccagcag      360

agccagtgcc ccgagggctt cgacctgccc cccgtgatcc tgttcagcat ggacggcttc      420

agagccgagt acctgtacac ctgggacacc ctgatgccca acatcaacaa gctgaagacc      480

tgcggcatcc acagcaagta catgagagcc atgtacccca ccaagacctt ccccaaccac      540

tacaccatcg tgaccggcct gtaccccgag agccacggca tcatcgacaa caacatgtac      600

gacgtgaacc tgaacaagaa cttcagcctg agcagcaagg agcagaacaa ccccgcctgg      660

tggcacggcc agcccatgaa cctgaccgcc atgtaccagg gcctgaaggc cgccacctac      720

ttctggcccg gcagcgaggt ggccatcaac ggcagcttcc ccagcatcta catgccctac      780

aacggcagcg tgcccttcga ggagagaatc agcaccctgc tgaagtggct ggacctgccc      840

aaggccgaga gacccagatt ctacaccatg tacttcgagg agcccgacag cagcggccac      900

gccggcggcc ccgtgagcgc cagagtgatc aaggccctgc aggtggtgga ccacgccttc      960

ggcatgctga tggagggcct gaagcagaga aacctgcaca actgcgtgaa catcatcctg     1020

ctggccgacc acggcatgga ccagacctac tgcaacaaga tggagtacat gaccgactac     1080

ttccccagaa tcaacttctt ctacatgtac gagggccccg cccccagaat cagagcccac     1140

aacatccccc acgacttctt cagcttcaac agcgaggaga tcgtgagaaa cctgagctgc     1200

agaaagcccg accagcactt caagccctac ctgacccccg acctgcccaa gagactgcac     1260

tacgccaaga acgtgagaat cgacaaggtg cacctgttcg tggaccagca gtggctggcc     1320

gtgagaagca agagcaacac caactgcggc ggcggcaacc acggctacaa caacgagttc     1380

agaagcatgg aggccatctt cctggcccac ggccccagct tcaaggagaa gaccgaggtg     1440

gagcccttcg agaacatcga ggtgtacaac ctgatgtgcg acctgctgag aatccagccc     1500

gcccccaaca acggcaccca cggcagcctg aaccacctgc tgaaggtgcc cttctacgag     1560

cccagccacg ccgaggaggt gagcaagttc agcgtgtgcg gcttcgccaa ccccctgccc     1620

accgagagcc tggactgctt ctgcccccac ctgcagaaca gcacccagct ggagcaggtg     1680

aaccagatgc tgaacctgac ccaggaggag atcaccgcca ccgtgaaggt gaacctgccc     1740

ttcggcagac ccagagtgct gcagaagaac gtggaccact gcctgctgta ccacagagag     1800

tacgtgagcg gcttcggcaa ggccatgaga atgcccatgt ggagcagcta caccgtgccc     1860

cagctgggcg acaccagccc cctgcccccc accgtgcccg actgcctgag agccgacgtg     1920

agagtgcccc ccagcgagag ccagaagtgc agcttctacc tggccgacaa gaacatcacc     1980

cacggcttcc tgtacccccc cgccagcaac agaaccagcg acagccagta cgacgccctg     2040

atcaccagca acctggtgcc catgtacgag gagttcagaa agatgtggga ctacttccac     2100

agcgtgctgc tgatcaagca cgccaccgag agaaacggcg tgaacgtggt gagcggcccc     2160

atcttcgact acaactacga cggccacttc gacgcccccg acgagatcac caagcacctg     2220

gccaacaccg acgtgcccat ccccacccac tacttcgtgg tgctgaccag ctgcaagaac     2280

aagagccaca cccccgagaa ctgccccggc tggctggacg tgctgccctt catcatcccc     2340

cacagaccca ccaacgtgga gagctgcccc gagggcaagc ccgaggccct gtgggtggag     2400

gagagattca ccgcccacat cgccagagtg agagacgtgg agctgctgac cggcctggac     2460

ttctaccagg acaaggtgca gcccgtgagc gagatcctgc agctgaagac ctacctgccc     2520

accttcgaga ccaccatcga caagacccac acctgccccc cctgccccgc ccccgagctg     2580

ctgggcggcc ccagcgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc     2640

agaacccccg aggtgacctg cgtggtggtg gacgtgagcc acgaggaccc cgaggtgaag     2700

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc cagagaggag     2760

cagtacaaca gcacctacag agtggtgagc gtgctgaccg tgctgcacca ggactggctg     2820

aacggcaagg agtacaagtg caaggtgagc aacaaggccc tgcccgcccc catcgagaag     2880

accatcagca aggccaaggg ccagcccaga gagccccagg tgtacaccct gccccccagc     2940

agagaggaga tgaccaagaa ccaggtgagc ctgacctgcc tggtgaaggg cttctacccc     3000

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc     3060

ccccccgtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     3120

agcagatggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc cctgcacaac     3180

cactacaccc agaagagcct gagcctgagc cccggcaag                            3219


