                               SEQUENCE LISTING

<110> SYNLOGIC OPERATING COMPANY, INC.
 
<120> RECOMBINANT BACTERIA FOR PRODUCTION OF INDOLE-3-ACETIC ACID (IAA)
      AND USES THEREOF

<130> 126046-05720

<140> Filed Herewith
<141> 2021-05-26

<150> 63/030,135
<151> 2020-05-26

<160> 23    

<170> PatentIn version 3.5

<210> 1
<211> 1560
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
atgcaaacac aaaaaccgac tctcgaactg ctaacctgcg aaggcgctta tcgcgacaac       60

ccgactgcgc tttttcacca gttgtgtggg gatcgtccgg caacgctgct gctggaattc      120

gcagatatcg acagcaaaga tgatttaaaa agcctgctgc tggtagacag tgcgctgcgc      180

attacagcat taagtgacac tgtcacaatc caggcgcttt ccggcaatgg agaagccctg      240

ttgacactac tggataacgc cttgcctgcg ggtgtggaaa atgaacaatc accaaactgc      300

cgcgtactgc gcttcccgcc tgtcagtcca ctgctggatg aagacgcccg cttatgctcc      360

ctttcggttt ttgacgcttt ccgcttatta cagaatctgt tgaatgtacc gaaggaagaa      420

cgagaagcaa tgttcttcgg cggcctgttc tcttatgacc ttgtggcggg atttgaaaat      480

ttaccgcaac tgtcagcgga aaatagctgc cctgatttct gtttttatct cgctgaaacg      540

ctgatggtga ttgaccatca gaaaaaaagc actcgtattc aggccagcct gtttgctccg      600

aatgaagaag aaaaacaacg tctcactgct cgcctgaacg aactacgtca gcaactgacc      660

gaagccgcgc cgccgctgcc ggtggtttcc gtgccgcata tgcgttgtga atgtaaccag      720

agcgatgaag agttcggtgg tgtagtgcgt ttgttgcaaa aagcgattcg cgccggagaa      780

attttccagg tggtgccatc tcgccgtttc tctctgccct gcccgtcacc gctggcagcc      840

tattacgtgc tgaaaaagag taatcccagc ccgtacatgt tttttatgca ggataatgat      900

ttcaccctgt ttggcgcgtc gccggaaagt tcgctcaagt atgacgccac cagccgccag      960

attgagattt acccgattgc cggaacacgt ccacgcggtc gtcgtgccga tggttcgctg     1020

gacagagacc tcgacagccg catcgaactg gagatgcgta ccgatcataa agagctttct     1080

gaacatctga tgctggtgga tctcgcccgt aatgacctgg cacgcatttg cacacccggc     1140

agccgctacg tcgccgatct caccaaagtt gaccgttact cttacgtgat gcacctagtc     1200

tcccgcgttg ttggtgagct gcgccacgat ctcgacgccc tgcacgctta ccgcgcctgt     1260

atgaatatgg ggacgttaag cggtgcaccg aaagtacgcg ctatgcagtt aattgccgaa     1320

gcagaaggtc gtcgacgcgg cagctacggc ggcgcggtag gttattttac cgcgcatggc     1380

gatctcgaca cctgcattgt gatccgctcg gcgctggtgg aaaacggtat cgccaccgtg     1440

caagccggtg ctggcgtagt ccttgattct gttccgcagt cggaagccga cgaaactcgt     1500

aataaagccc gcgctgtact gcgcgctatt gccaccgcgc atcatgcaca ggagacgttc     1560


<210> 2
<211> 1194
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
atgacaacat tacttaaccc ctattttggt gagtttggcg gcatgtacgt gccacaaatc       60

ctgatgcctg ctctgcgcca gctggaagaa gcttttgtca gcgcgcaaaa agatcctgaa      120

tttcaggctc agttcaacga cctgctgaaa aactatgccg ggcgtccaac cgcgctgacc      180

aaatgccaga acattacagc cgggacgaac accacgctgt atctgaagcg cgaagatttg      240

ctgcacggcg gcgcgcataa aactaaccag gtgctcggtc aggctttact ggcgaagcgg      300

atgggtaaaa ctgaaattat tgccgaaacc ggtgccggtc agcatggcgt ggcgtcggcc      360

cttgccagcg ccctgctcgg cctgaaatgc cgaatttata tgggtgccaa agacgttgaa      420

cgccagtcgc ccaacgtttt ccggatgcgc ttaatgggtg cggaagtgat cccggtacat      480

agcggttccg cgaccctgaa agatgcctgt aatgaggcgc tacgcgactg gtccggcagt      540

tatgaaaccg cgcactatat gctgggtacc gcagctggcc cgcatcctta cccgaccatt      600

gtgcgtgagt ttcagcggat gattggcgaa gaaacgaaag cgcagattct ggaaagagaa      660

ggtcgcctgc cggatgccgt tatcgcctgt gttggcggtg gttcgaatgc catcggtatg      720

tttgcagatt tcatcaacga aaccgacgtc ggcctgattg gtgtggagcc tggcggccac      780

ggtatcgaaa ctggcgagca cggcgcaccg ttaaaacatg gtcgcgtggg catctatttc      840

ggtatgaaag cgccgatgat gcaaaccgaa gacgggcaaa ttgaagagtc ttactccatt      900

tctgccgggc tggatttccc gtccgtcggc ccgcaacatg cgtatctcaa cagcactgga      960

cgcgctgatt acgtgtctat taccgacgat gaagccctgg aagcctttaa aacgctttgc     1020

ctgcatgaag ggatcatccc ggcgctggaa tcctcccacg ccctggccca tgcgctgaaa     1080

atgatgcgcg aaaatccgga aaaagagcag ctactggtgg ttaacctttc cggtcgcggc     1140

gataaagaca tcttcaccgt tcacgatatt ttgaaagcac gaggggaaat ctga           1194


<210> 3
<211> 1359
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atgcaaaccg ttttagcgaa aatcgtcgca gacaaggcga tttgggtaga aacccgcaaa       60

gagcagcaac cgctggccag ttttcagaat gaggttcagc cgagcacgcg acatttttat      120

gatgcacttc agggcgcacg cacggcgttt attctggagt gtaaaaaagc gtcgccgtca      180

aaaggcgtga tccgtgatga tttcgatccg gcacgcattg ccgccattta taaacattac      240

gcttcggcaa tttcagtgct gactgatgag aaatattttc aggggagctt tgatttcctc      300

cccatcgtca gccaaatcgc cccgcagccg attttatgta aagacttcat tatcgatcct      360

taccagatct atctggcgcg ctattaccag gccgatgcct gcttattaat gctttcagta      420

ctggatgacg aacaatatcg ccagcttgca gccgtcgccc acagtctgga gatgggtgtg      480

ctgaccgaag tcagtaatga agaggaactg gagcgcgcca ttgcattggg ggcaaaggtc      540

gttggcatca acaaccgcga tctgcgcgat ttgtcgattg atctcaaccg tacccgcgag      600

cttgcgccga aactggggca caacgtgacg gtaatcagcg aatccggcat caatacttac      660

gctcaggtgc gcgagttaag ccacttcgct aacggctttc tgattggttc ggcgttgatg      720

gcccatgacg atttgaacgc cgccgtgcgt cgggtgttgc tgggtgagaa taaagtatgt      780

ggcctgacac gtgggcaaga tgctaaagca gcttatgacg cgggcgcgat ttacggtggg      840

ttgatttttg ttgcgacatc accgcgttgc gtcaacgttg aacaggcgca ggaagtgatg      900

gctgcagcac cgttgcagta tgttggcgtg ttccgcaatc acgatattgc cgatgtggcg      960

gacaaagcta aggtgttatc gctggcggca gtgcaactgc atggtaatga agatcagctg     1020

tatatcgaca atctgcgtga ggctctgcca gcacacgtcg ccatctggaa ggctttaagt     1080

gtcggtgaaa ctcttcccgc gcgcgatttt cagcacatcg ataaatatgt attcgacaac     1140

ggtcagggcg ggagcggaca acgtttcgac tggtcactat taaatggtca atcgcttggc     1200

aacgttctgc tggcgggggg cttaggcgca gataactgcg tggaagcggc acaaaccggc     1260

tgcgccgggc ttgattttaa ttctgctgta gagtcgcaac cgggtatcaa agacgcacgt     1320

cttttggcct cggttttcca gacgctgcgc gcatattaa                            1359


<210> 4
<211> 1596
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atggctgaca ttctgctgct cgataatatc gactctttta cgtacaacct ggcagatcag       60

ttgcgcagca atggtcataa cgtggtgatt taccgcaacc atattccggc gcagacctta      120

attgaacgcc tggcgacgat gagcaatccg gtgctgatgc tttctcctgg ccccggtgtg      180

ccgagcgaag ccggttgtat gccggaactc ctcacccgct tgcgtggcaa gctgccaatt      240

attggcattt gcctcggaca tcaggcgatt gtcgaagctt acgggggcta tgtcggtcag      300

gcgggcgaaa ttcttcacgg taaagcgtcg agcattgaac atgacggtca ggcgatgttt      360

gccggattaa caaacccgct gccagtggcg cgttatcact cgctggttgg cagtaacatt      420

ccggccggtt taaccatcaa cgcccatttt aatggcatgg tgatggcggt gcgtcacgat      480

gcagatcgcg tttgtggatt ccagttccat ccggaatcca ttcttactac ccagggcgct      540

cgcctgctgg aacaaacgct ggcctgggcg cagcagaaac tagagccaac caacacgctg      600

caaccgattc tggaaaaact gtatcaggca cagacgctta gccaacaaga aagccaccag      660

ctgttttcag cggtggtacg tggcgagctg aagccggaac aactggcggc ggcgctggtg      720

agcatgaaaa ttcgcggtga acacccgaac gagatcgccg gggcagcaac cgcgctactg      780

gaaaacgccg cgccattccc gcgcccggat tatctgtttg ccgatatcgt cggtactggc      840

ggtgacggca gcaacagcat caatatttct accgccagtg cgtttgtcgc cgcggcctgc      900

gggctgaaag tggcgaaaca cggcaaccgt agcgtctcca gtaaatccgg ctcgtcggat      960

ctgctggcgg cgttcggtat taatcttgat atgaacgccg ataaatcgcg ccaggcgctg     1020

gatgagttag gcgtctgttt cctctttgcg ccgaagtatc acaccggatt ccgccatgcg     1080

atgccggttc gccagcaact gaaaacccgc actctgttca acgtgctggg accattgatt     1140

aacccggcgc atccgccgct ggcgctaatt ggtgtttata gtccggaact ggtgctgccg     1200

attgccgaaa ccttgcgcgt gctggggtat caacgcgcgg cagtggtgca cagcggcggg     1260

atggatgaag tttcattaca cgcgccgaca atcgttgccg aactacatga cggcgaaatt     1320

aagagctatc aattgaccgc tgaagatttt ggcctgacac cctaccacca ggagcaattg     1380

gcaggcggaa caccggaaga aaaccgtgac attttaacac gcttgttaca aggtaaaggc     1440

gacgccgccc atgaagcagc cgtcgcggcg aatgtcgcca tgttaatgcg cctgcatggc     1500

catgaagatc tgcaagccaa tgcgcaaacc gttcttgagg tactgcgcag tggttccgct     1560

tacgacagag tcaccgcact ggcggcacga gggtaa                               1596


<210> 5
<211> 807
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
atggaacgct acgaatctct gtttgcccag ttgaaggagc gcaaagaagg cgcattcgtt       60

cctttcgtca ccctcggtga tccgggcatt gagcagtcgt tgaaaattat cgatacgcta      120

attgaagccg gtgctgacgc gctggagtta ggcatcccct tctccgaccc actggcggat      180

ggcccgacga ttcaaaacgc cacactgcgt gcttttgcgg cgggagtaac cccggcgcag      240

tgctttgaga tgctggcact cattcgccag aagcacccga ccattcccat cggccttttg      300

atgtatgcca acctggtgtt taacaaaggc attgatgagt tttatgccga gtgcgagaaa      360

gtcggcgtcg attcggtgct ggttgccgat gtgcccgtgg aagagtccgc gcccttccgc      420

caggccgcgt tgcgtcataa tgtcgcacct atctttattt gcccgccgaa tgccgacgat      480

gatttgctgc gccagatagc ctcttacggt cgtggttaca cctatttgct gtcgcgagcg      540

ggcgtgaccg gcgcagaaaa ccgcgccgcg ttacccctca atcatctggt tgcgaagctg      600

aaagagtaca acgctgcgcc tccattgcag ggatttggta tttccgcccc ggatcaggta      660

aaagccgcga ttgatgcagg agctgcgggc gcgatttctg gttcggccat cgttaaaatc      720

atcgagcaac atattaatga gccagagaaa atgctggcgg cactgaaagc ttttgtacaa      780

ccgatgaaag cggcgacgcg cagttaa                                          807


<210> 6
<211> 1050
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
atgaattatc agaacgacga tttacgcatc aaagaaatca aagagttact tcctcctgtc       60

gcattgctgg aaaaattccc cgctactgaa aatgccgcga atacggtcgc ccatgcccga      120

aaagcgatcc ataagatcct gaaaggtaat gatgatcgcc tgttggtggt gattggccca      180

tgctcaattc atgatcctgt cgcggctaaa gagtatgcca ctcgcttgct gacgctgcgt      240

gaagagctgc aagatgagct ggaaatcgtg atgcgcgtct attttgaaaa gccgcgtact      300

acggtgggct ggaaagggct gattaacgat ccgcatatgg ataacagctt ccagatcaac      360

gacggtctgc gtattgcccg caaattgctg ctcgatatta acgacagcgg tctgccagcg      420

gcgggtgaat tcctggatat gatcacccta caatatctcg ctgacctgat gagctggggc      480

gcaattggcg cacgtaccac cgaatcgcag gtgcaccgcg aactggcgtc tggtctttct      540

tgtccggtag gtttcaaaaa tggcactgat ggtacgatta aagtggctat cgatgccatt      600

aatgccgccg gtgcgccgca ctgcttcctg tccgtaacga aatgggggca ttcggcgatt      660

gtgaatacca gcggtaacgg cgattgccat atcattctgc gcggcggtaa agagcctaac      720

tacagcgcga agcacgttgc tgaagtgaaa gaagggctga acaaagcagg cctgccagcg      780

caggtgatga tcgatttcag ccatgctaac tcgtcaaaac aattcaaaaa gcagatggat      840

gtttgtactg acgtttgcca gcagattgcc ggtggcgaaa aggccattat tggcgtgatg      900

gtggaaagcc atctggtgga aggcaatcag agcctcgaga gcggggaacc gctggcctac      960

ggtaagagca tcaccgatgc ctgcattggc tgggatgata ccgatgctct gttacgtcaa     1020

ctggcgagtg cagtaaaagc gcgtcgcggg                                      1050


<210> 7
<211> 1059
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atgctgttat tcgagactgt gcgtgaaatg ggtcatgagc aagtcctttt ctgtcatagc       60

aagaatcccg agatcaaggc aattatcgca atccacgata ccaccttagg accggctatg      120

ggcgcaactc gtatcttacc ttatattaat gaggaggctg ccctgaaaga tgcattacgt      180

ctgtcccgcg gaatgactta caaagcagcc tgcgccaata ttcccgccgg gggcggcaaa      240

gccgtcatca tcgctaaccc cgaaaacaag accgatgacc tgttacgcgc atacggccgt      300

ttcgtggaca gcttgaacgg ccgtttcatc accgggcagg acgttaacat tacgcccgac      360

gacgttcgca ctatttcgca ggagactaag tacgtggtag gcgtctcaga aaagtcggga      420

gggccggcac ctatcacctc tctgggagta tttttaggca tcaaagccgc tgtagagtcg      480

cgttggcagt ctaaacgcct ggatggcatg aaagtggcgg tgcaaggact tgggaacgta      540

ggaaaaaatc tttgtcgcca tctgcatgaa cacgatgtac aactttttgt gtctgatgtc      600

gatccaatca aggccgagga agtaaaacgc ttattcgggg cgactgttgt cgaaccgact      660

gaaatctatt ctttagatgt tgatattttt gcaccgtgtg cacttggggg tattttgaat      720

agccatacca tcccgttctt acaagcctca atcatcgcag gagcagcgaa taaccagctg      780

gagaacgagc aacttcattc gcagatgctt gcgaaaaagg gtattcttta ctcaccagac      840

tacgttatca atgcaggagg acttatcaat gtttataacg aaatgatcgg atatgacgag      900

gaaaaagcat tcaaacaagt tcataacatc tacgatacgt tattagcgat tttcgaaatt      960

gcaaaagaac aaggtgtaac caccaacgac gcggcccgtc gtttagcaga ggatcgtatc     1020

aacaactcca aacgctcaaa gagtaaagcg attgcggcg                            1059


<210> 8
<211> 1656
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atgcgcactc catattgtgt cgctgattac ctgttggacc gcttgactga ttgcggtgca       60

gatcacctgt tcggtgttcc aggcgattac aacctgcaat tcctggatca cgttatcgac      120

tcacctgaca tttgctgggt cgggtgtgcg aatgagttaa acgcttccta tgcagcagac      180

ggctatgcac gctgtaaggg gtttgcagca ttgctgacca cttttggtgt gggagaattg      240

agtgcaatga acgggatcgc aggatcctat gctgagcatg tgccagtgtt gcatatcgtt      300

ggtgcaccag gtactgctgc ccaacagcgt ggtgagctgt tgcatcacac cttaggtgat      360

ggtgagtttc gccacttcta ccatatgagc gaacccatta cagtcgctca agctgttctg      420

acggagcaga atgcgtgcta cgaaatcgat cgtgttctta ccaccatgtt gcgtgaacgt      480

cgtcctgggt atctgatgtt gccagcagat gtcgcgaaga aagcagccac accaccagtc      540

aatgcactga cacataagca agctcacgca gattctgcct gtttgaaggc gtttcgtgat      600

gcagctgaga acaagcttgc catgtcgaag cgtacggcac ttcttgcgga tttcctggtt      660

ctgcgtcatg gcctgaagca cgcacttcag aaatgggtta aggaagtgcc tatggcacat      720

gccacgatgc ttatgggtaa gggtatcttt gacgaacgcc aagcaggatt ctatggaaca      780

tacagtggaa gcgcatccac tggtgctgtc aaggaagcca tcgaaggagc ggatactgtg      840

ctttgcgttg ggacccgttt cacagacacg ttaacagctg gatttaccca ccaattaacg      900

ccagctcaga ccattgaagt acaacctcat gcagcacgtg ttggtgatgt ctggttcact      960

ggtattccca tgaaccaagc tatcgagaca ctggtcgaat tgtgcaaaca acatgtccat     1020

gcaggcttga tgagctcgtc aagtggtgct attcccttcc cacaaccaga cggctccttg     1080

acgcaggaga acttctggcg tacccttcaa actttcattc gtccaggtga catcattctt     1140

gcagatcaag gtacttcggc gtttggtgct attgacttgc gtcttccagc tgacgtgaac     1200

ttcattgtcc agcctctgtg gggttcgatc ggatacactc ttgctgcagc attcggtgca     1260

caaacagctt gtcctaatcg tcgcgtaatc gtcctgactg gtgacggtgc agctcagttg     1320

acaattcagg agttaggcag catgttacgt gataagcaac acccaatcat cttggtcctg     1380

aacaacgagg gttacactgt agagcgtgcc atccatggtg cagaacaacg ttacaacgac     1440

attgcgttgt ggaattggac ccatattcca caagctttaa gcctggatcc gcaaagtgag     1500

tgctggcgtg tatccgaagc tgaacaactg gcagatgtgc tggagaaggt cgcacatcat     1560

gaacgcttat cgttgatcga agtcatgttg cctaaggcag atattccacc attgttaggt     1620

gctctgacga aagccttgga ggcgtgtaac aacgcc                               1656


<210> 9
<211> 1491
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atgcccactt tgaaccttga tctgccgaac ggcattaaat cgacgattca ggctgatttg       60

ttcatcaata acaagttcgt cccagcactt gatggcaaga catttgcgac aatcaatcca      120

tcgacaggaa aagaaatcgg ccaggtggca gaggcttccg caaaggacgt ggacctggca      180

gttaaggctg cacgcgaagc cttcgagacc acttggggtg agaacacacc aggtgatgca      240

cgtggtcgct tgttgatcaa actggctgag cttgtggagg ccaacattga cgagcttgca      300

gcgattgaat ccctggataa tggtaaggct ttctcaattg caaagtcctt cgatgtagct      360

gcggttgctg ccaacttacg ttactatggt ggctgggctg ataagaacca tggtaaagta      420

atggaggtcg atacaaagcg tctgaactat acgcgtcacg agcccatcgg agtctgtgga      480

cagatcattc catggaactt tccactgctc atgtttgctt ggaagttggg accagccttg      540

gctactggca atacgatcgt cctgaagact gcagagcaaa cacctctgtc ggctatcaag      600

atgtgtgaat tgatcgtgga ggcaggattt cctccaggcg tagtaaatgt gatctcgggc      660

tttggtcctg tcgcaggagc agcgatctca cagcacatgg acatcgataa gatcgctttc      720

acaggaagta ccctggtagg acgtaacatc atgaaggcag cagcatccac gaacctgaag      780

aaggtcacgc tggaattggg tggaaagagt cctaacatca tcttcaagga cgcggattta      840

gatcaagctg tgcgttggag tgcgttcgga atcatgttca atcacggcca gtgctgctgt      900

gcagggagtc gcgtgtatgt agaggagtcc atctatgatg ctttcatgga gaagatgacg      960

gcacattgta aggcactgca agttggtgat cctttctccg caaatacgtt ccagggtccg     1020

caagtttcac aattgcaata tgaccgtatc atggagtaca tcgaatctgg caagaaggac     1080

gcaaatctgg cattgggagg cgtccgtaag gggaacgaag gttacttcat cgaaccgaca     1140

atctttactg acgtccctca tgatgcaaag attgctaagg aagagatctt tggacctgta     1200

gtcgttgtat ccaagtttaa ggatgagaaa gatttgatcc gcatcgccaa tgatagcatt     1260

tatggccttg cagcagcagt cttctctcgc gacatttcac gtgcgatcga aacagctcat     1320

aagctgaagg caggtacagt atgggttaac tgctacaatc agttgatccc acaagttcca     1380

ttcggtgggt acaaagcgtc cgggatcggt cgcgaattag gagaatatgc gttatctaac     1440

tataccaata tcaaggcggt ccatgttaat ctgagtcaac ctgctcccat t              1491


<210> 10
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
acctattggt ataaggaggt aaata                                             25


<210> 11
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
taggaggttt ctatcaaatt aaggaggtta tt                                     32


<210> 12
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
ggtaggacga ttgtccggta gatttaagga ggattttttt tt                          42


<210> 13
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
tcattttagt caatatcagt attgattcca tacacgtaag gaggttattt                  50


<210> 14
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Gln Thr Gln Lys Pro Thr Leu Glu Leu Leu Thr Cys Glu Gly Ala 
1               5                   10                  15      


Tyr Arg Asp Asn Pro Thr Ala Leu Phe His Gln Leu Cys Gly Asp Arg 
            20                  25                  30          


Pro Ala Thr Leu Leu Leu Glu Phe Ala Asp Ile Asp Ser Lys Asp Asp 
        35                  40                  45              


Leu Lys Ser Leu Leu Leu Val Asp Ser Ala Leu Arg Ile Thr Ala Leu 
    50                  55                  60                  


Ser Asp Thr Val Thr Ile Gln Ala Leu Ser Gly Asn Gly Glu Ala Leu 
65                  70                  75                  80  


Leu Thr Leu Leu Asp Asn Ala Leu Pro Ala Gly Val Glu Asn Glu Gln 
                85                  90                  95      


Ser Pro Asn Cys Arg Val Leu Arg Phe Pro Pro Val Ser Pro Leu Leu 
            100                 105                 110         


Asp Glu Asp Ala Arg Leu Cys Ser Leu Ser Val Phe Asp Ala Phe Arg 
        115                 120                 125             


Leu Leu Gln Asn Leu Leu Asn Val Pro Lys Glu Glu Arg Glu Ala Met 
    130                 135                 140                 


Phe Phe Gly Gly Leu Phe Ser Tyr Asp Leu Val Ala Gly Phe Glu Asn 
145                 150                 155                 160 


Leu Pro Gln Leu Ser Ala Glu Asn Ser Cys Pro Asp Phe Cys Phe Tyr 
                165                 170                 175     


Leu Ala Glu Thr Leu Met Val Ile Asp His Gln Lys Lys Ser Thr Arg 
            180                 185                 190         


Ile Gln Ala Ser Leu Phe Ala Pro Asn Glu Glu Glu Lys Gln Arg Leu 
        195                 200                 205             


Thr Ala Arg Leu Asn Glu Leu Arg Gln Gln Leu Thr Glu Ala Ala Pro 
    210                 215                 220                 


Pro Leu Pro Val Val Ser Val Pro His Met Arg Cys Glu Cys Asn Gln 
225                 230                 235                 240 


Ser Asp Glu Glu Phe Gly Gly Val Val Arg Leu Leu Gln Lys Ala Ile 
                245                 250                 255     


Arg Ala Gly Glu Ile Phe Gln Val Val Pro Ser Arg Arg Phe Ser Leu 
            260                 265                 270         


Pro Cys Pro Ser Pro Leu Ala Ala Tyr Tyr Val Leu Lys Lys Ser Asn 
        275                 280                 285             


Pro Ser Pro Tyr Met Phe Phe Met Gln Asp Asn Asp Phe Thr Leu Phe 
    290                 295                 300                 


Gly Ala Ser Pro Glu Ser Ser Leu Lys Tyr Asp Ala Thr Ser Arg Gln 
305                 310                 315                 320 


Ile Glu Ile Tyr Pro Ile Ala Gly Thr Arg Pro Arg Gly Arg Arg Ala 
                325                 330                 335     


Asp Gly Ser Leu Asp Arg Asp Leu Asp Ser Arg Ile Glu Leu Glu Met 
            340                 345                 350         


Arg Thr Asp His Lys Glu Leu Ser Glu His Leu Met Leu Val Asp Leu 
        355                 360                 365             


Ala Arg Asn Asp Leu Ala Arg Ile Cys Thr Pro Gly Ser Arg Tyr Val 
    370                 375                 380                 


Ala Asp Leu Thr Lys Val Asp Arg Tyr Ser Tyr Val Met His Leu Val 
385                 390                 395                 400 


Ser Arg Val Val Gly Glu Leu Arg His Asp Leu Asp Ala Leu His Ala 
                405                 410                 415     


Tyr Arg Ala Cys Met Asn Met Gly Thr Leu Ser Gly Ala Pro Lys Val 
            420                 425                 430         


Arg Ala Met Gln Leu Ile Ala Glu Ala Glu Gly Arg Arg Arg Gly Ser 
        435                 440                 445             


Tyr Gly Gly Ala Val Gly Tyr Phe Thr Ala His Gly Asp Leu Asp Thr 
    450                 455                 460                 


Cys Ile Val Ile Arg Ser Ala Leu Val Glu Asn Gly Ile Ala Thr Val 
465                 470                 475                 480 


Gln Ala Gly Ala Gly Val Val Leu Asp Ser Val Pro Gln Ser Glu Ala 
                485                 490                 495     


Asp Glu Thr Arg Asn Lys Ala Arg Ala Val Leu Arg Ala Ile Ala Thr 
            500                 505                 510         


Ala His His Ala Gln Glu Thr Phe 
        515                 520 


<210> 15
<211> 397
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Thr Thr Leu Leu Asn Pro Tyr Phe Gly Glu Phe Gly Gly Met Tyr 
1               5                   10                  15      


Val Pro Gln Ile Leu Met Pro Ala Leu Arg Gln Leu Glu Glu Ala Phe 
            20                  25                  30          


Val Ser Ala Gln Lys Asp Pro Glu Phe Gln Ala Gln Phe Asn Asp Leu 
        35                  40                  45              


Leu Lys Asn Tyr Ala Gly Arg Pro Thr Ala Leu Thr Lys Cys Gln Asn 
    50                  55                  60                  


Ile Thr Ala Gly Thr Asn Thr Thr Leu Tyr Leu Lys Arg Glu Asp Leu 
65                  70                  75                  80  


Leu His Gly Gly Ala His Lys Thr Asn Gln Val Leu Gly Gln Ala Leu 
                85                  90                  95      


Leu Ala Lys Arg Met Gly Lys Thr Glu Ile Ile Ala Glu Thr Gly Ala 
            100                 105                 110         


Gly Gln His Gly Val Ala Ser Ala Leu Ala Ser Ala Leu Leu Gly Leu 
        115                 120                 125             


Lys Cys Arg Ile Tyr Met Gly Ala Lys Asp Val Glu Arg Gln Ser Pro 
    130                 135                 140                 


Asn Val Phe Arg Met Arg Leu Met Gly Ala Glu Val Ile Pro Val His 
145                 150                 155                 160 


Ser Gly Ser Ala Thr Leu Lys Asp Ala Cys Asn Glu Ala Leu Arg Asp 
                165                 170                 175     


Trp Ser Gly Ser Tyr Glu Thr Ala His Tyr Met Leu Gly Thr Ala Ala 
            180                 185                 190         


Gly Pro His Pro Tyr Pro Thr Ile Val Arg Glu Phe Gln Arg Met Ile 
        195                 200                 205             


Gly Glu Glu Thr Lys Ala Gln Ile Leu Glu Arg Glu Gly Arg Leu Pro 
    210                 215                 220                 


Asp Ala Val Ile Ala Cys Val Gly Gly Gly Ser Asn Ala Ile Gly Met 
225                 230                 235                 240 


Phe Ala Asp Phe Ile Asn Glu Thr Asp Val Gly Leu Ile Gly Val Glu 
                245                 250                 255     


Pro Gly Gly His Gly Ile Glu Thr Gly Glu His Gly Ala Pro Leu Lys 
            260                 265                 270         


His Gly Arg Val Gly Ile Tyr Phe Gly Met Lys Ala Pro Met Met Gln 
        275                 280                 285             


Thr Glu Asp Gly Gln Ile Glu Glu Ser Tyr Ser Ile Ser Ala Gly Leu 
    290                 295                 300                 


Asp Phe Pro Ser Val Gly Pro Gln His Ala Tyr Leu Asn Ser Thr Gly 
305                 310                 315                 320 


Arg Ala Asp Tyr Val Ser Ile Thr Asp Asp Glu Ala Leu Glu Ala Phe 
                325                 330                 335     


Lys Thr Leu Cys Leu His Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser 
            340                 345                 350         


His Ala Leu Ala His Ala Leu Lys Met Met Arg Glu Asn Pro Glu Lys 
        355                 360                 365             


Glu Gln Leu Leu Val Val Asn Leu Ser Gly Arg Gly Asp Lys Asp Ile 
    370                 375                 380                 


Phe Thr Val His Asp Ile Leu Lys Ala Arg Gly Glu Ile 
385                 390                 395         


<210> 16
<211> 452
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Gln Thr Val Leu Ala Lys Ile Val Ala Asp Lys Ala Ile Trp Val 
1               5                   10                  15      


Glu Thr Arg Lys Glu Gln Gln Pro Leu Ala Ser Phe Gln Asn Glu Val 
            20                  25                  30          


Gln Pro Ser Thr Arg His Phe Tyr Asp Ala Leu Gln Gly Ala Arg Thr 
        35                  40                  45              


Ala Phe Ile Leu Glu Cys Lys Lys Ala Ser Pro Ser Lys Gly Val Ile 
    50                  55                  60                  


Arg Asp Asp Phe Asp Pro Ala Arg Ile Ala Ala Ile Tyr Lys His Tyr 
65                  70                  75                  80  


Ala Ser Ala Ile Ser Val Leu Thr Asp Glu Lys Tyr Phe Gln Gly Ser 
                85                  90                  95      


Phe Asp Phe Leu Pro Ile Val Ser Gln Ile Ala Pro Gln Pro Ile Leu 
            100                 105                 110         


Cys Lys Asp Phe Ile Ile Asp Pro Tyr Gln Ile Tyr Leu Ala Arg Tyr 
        115                 120                 125             


Tyr Gln Ala Asp Ala Cys Leu Leu Met Leu Ser Val Leu Asp Asp Glu 
    130                 135                 140                 


Gln Tyr Arg Gln Leu Ala Ala Val Ala His Ser Leu Glu Met Gly Val 
145                 150                 155                 160 


Leu Thr Glu Val Ser Asn Glu Glu Glu Leu Glu Arg Ala Ile Ala Leu 
                165                 170                 175     


Gly Ala Lys Val Val Gly Ile Asn Asn Arg Asp Leu Arg Asp Leu Ser 
            180                 185                 190         


Ile Asp Leu Asn Arg Thr Arg Glu Leu Ala Pro Lys Leu Gly His Asn 
        195                 200                 205             


Val Thr Val Ile Ser Glu Ser Gly Ile Asn Thr Tyr Ala Gln Val Arg 
    210                 215                 220                 


Glu Leu Ser His Phe Ala Asn Gly Phe Leu Ile Gly Ser Ala Leu Met 
225                 230                 235                 240 


Ala His Asp Asp Leu Asn Ala Ala Val Arg Arg Val Leu Leu Gly Glu 
                245                 250                 255     


Asn Lys Val Cys Gly Leu Thr Arg Gly Gln Asp Ala Lys Ala Ala Tyr 
            260                 265                 270         


Asp Ala Gly Ala Ile Tyr Gly Gly Leu Ile Phe Val Ala Thr Ser Pro 
        275                 280                 285             


Arg Cys Val Asn Val Glu Gln Ala Gln Glu Val Met Ala Ala Ala Pro 
    290                 295                 300                 


Leu Gln Tyr Val Gly Val Phe Arg Asn His Asp Ile Ala Asp Val Ala 
305                 310                 315                 320 


Asp Lys Ala Lys Val Leu Ser Leu Ala Ala Val Gln Leu His Gly Asn 
                325                 330                 335     


Glu Asp Gln Leu Tyr Ile Asp Asn Leu Arg Glu Ala Leu Pro Ala His 
            340                 345                 350         


Val Ala Ile Trp Lys Ala Leu Ser Val Gly Glu Thr Leu Pro Ala Arg 
        355                 360                 365             


Asp Phe Gln His Ile Asp Lys Tyr Val Phe Asp Asn Gly Gln Gly Gly 
    370                 375                 380                 


Ser Gly Gln Arg Phe Asp Trp Ser Leu Leu Asn Gly Gln Ser Leu Gly 
385                 390                 395                 400 


Asn Val Leu Leu Ala Gly Gly Leu Gly Ala Asp Asn Cys Val Glu Ala 
                405                 410                 415     


Ala Gln Thr Gly Cys Ala Gly Leu Asp Phe Asn Ser Ala Val Glu Ser 
            420                 425                 430         


Gln Pro Gly Ile Lys Asp Ala Arg Leu Leu Ala Ser Val Phe Gln Thr 
        435                 440                 445             


Leu Arg Ala Tyr 
    450         


<210> 17
<211> 531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Ala Asp Ile Leu Leu Leu Asp Asn Ile Asp Ser Phe Thr Tyr Asn 
1               5                   10                  15      


Leu Ala Asp Gln Leu Arg Ser Asn Gly His Asn Val Val Ile Tyr Arg 
            20                  25                  30          


Asn His Ile Pro Ala Gln Thr Leu Ile Glu Arg Leu Ala Thr Met Ser 
        35                  40                  45              


Asn Pro Val Leu Met Leu Ser Pro Gly Pro Gly Val Pro Ser Glu Ala 
    50                  55                  60                  


Gly Cys Met Pro Glu Leu Leu Thr Arg Leu Arg Gly Lys Leu Pro Ile 
65                  70                  75                  80  


Ile Gly Ile Cys Leu Gly His Gln Ala Ile Val Glu Ala Tyr Gly Gly 
                85                  90                  95      


Tyr Val Gly Gln Ala Gly Glu Ile Leu His Gly Lys Ala Ser Ser Ile 
            100                 105                 110         


Glu His Asp Gly Gln Ala Met Phe Ala Gly Leu Thr Asn Pro Leu Pro 
        115                 120                 125             


Val Ala Arg Tyr His Ser Leu Val Gly Ser Asn Ile Pro Ala Gly Leu 
    130                 135                 140                 


Thr Ile Asn Ala His Phe Asn Gly Met Val Met Ala Val Arg His Asp 
145                 150                 155                 160 


Ala Asp Arg Val Cys Gly Phe Gln Phe His Pro Glu Ser Ile Leu Thr 
                165                 170                 175     


Thr Gln Gly Ala Arg Leu Leu Glu Gln Thr Leu Ala Trp Ala Gln Gln 
            180                 185                 190         


Lys Leu Glu Pro Thr Asn Thr Leu Gln Pro Ile Leu Glu Lys Leu Tyr 
        195                 200                 205             


Gln Ala Gln Thr Leu Ser Gln Gln Glu Ser His Gln Leu Phe Ser Ala 
    210                 215                 220                 


Val Val Arg Gly Glu Leu Lys Pro Glu Gln Leu Ala Ala Ala Leu Val 
225                 230                 235                 240 


Ser Met Lys Ile Arg Gly Glu His Pro Asn Glu Ile Ala Gly Ala Ala 
                245                 250                 255     


Thr Ala Leu Leu Glu Asn Ala Ala Pro Phe Pro Arg Pro Asp Tyr Leu 
            260                 265                 270         


Phe Ala Asp Ile Val Gly Thr Gly Gly Asp Gly Ser Asn Ser Ile Asn 
        275                 280                 285             


Ile Ser Thr Ala Ser Ala Phe Val Ala Ala Ala Cys Gly Leu Lys Val 
    290                 295                 300                 


Ala Lys His Gly Asn Arg Ser Val Ser Ser Lys Ser Gly Ser Ser Asp 
305                 310                 315                 320 


Leu Leu Ala Ala Phe Gly Ile Asn Leu Asp Met Asn Ala Asp Lys Ser 
                325                 330                 335     


Arg Gln Ala Leu Asp Glu Leu Gly Val Cys Phe Leu Phe Ala Pro Lys 
            340                 345                 350         


Tyr His Thr Gly Phe Arg His Ala Met Pro Val Arg Gln Gln Leu Lys 
        355                 360                 365             


Thr Arg Thr Leu Phe Asn Val Leu Gly Pro Leu Ile Asn Pro Ala His 
    370                 375                 380                 


Pro Pro Leu Ala Leu Ile Gly Val Tyr Ser Pro Glu Leu Val Leu Pro 
385                 390                 395                 400 


Ile Ala Glu Thr Leu Arg Val Leu Gly Tyr Gln Arg Ala Ala Val Val 
                405                 410                 415     


His Ser Gly Gly Met Asp Glu Val Ser Leu His Ala Pro Thr Ile Val 
            420                 425                 430         


Ala Glu Leu His Asp Gly Glu Ile Lys Ser Tyr Gln Leu Thr Ala Glu 
        435                 440                 445             


Asp Phe Gly Leu Thr Pro Tyr His Gln Glu Gln Leu Ala Gly Gly Thr 
    450                 455                 460                 


Pro Glu Glu Asn Arg Asp Ile Leu Thr Arg Leu Leu Gln Gly Lys Gly 
465                 470                 475                 480 


Asp Ala Ala His Glu Ala Ala Val Ala Ala Asn Val Ala Met Leu Met 
                485                 490                 495     


Arg Leu His Gly His Glu Asp Leu Gln Ala Asn Ala Gln Thr Val Leu 
            500                 505                 510         


Glu Val Leu Arg Ser Gly Ser Ala Tyr Asp Arg Val Thr Ala Leu Ala 
        515                 520                 525             


Ala Arg Gly 
    530     


<210> 18
<211> 268
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Glu Arg Tyr Glu Ser Leu Phe Ala Gln Leu Lys Glu Arg Lys Glu 
1               5                   10                  15      


Gly Ala Phe Val Pro Phe Val Thr Leu Gly Asp Pro Gly Ile Glu Gln 
            20                  25                  30          


Ser Leu Lys Ile Ile Asp Thr Leu Ile Glu Ala Gly Ala Asp Ala Leu 
        35                  40                  45              


Glu Leu Gly Ile Pro Phe Ser Asp Pro Leu Ala Asp Gly Pro Thr Ile 
    50                  55                  60                  


Gln Asn Ala Thr Leu Arg Ala Phe Ala Ala Gly Val Thr Pro Ala Gln 
65                  70                  75                  80  


Cys Phe Glu Met Leu Ala Leu Ile Arg Gln Lys His Pro Thr Ile Pro 
                85                  90                  95      


Ile Gly Leu Leu Met Tyr Ala Asn Leu Val Phe Asn Lys Gly Ile Asp 
            100                 105                 110         


Glu Phe Tyr Ala Glu Cys Glu Lys Val Gly Val Asp Ser Val Leu Val 
        115                 120                 125             


Ala Asp Val Pro Val Glu Glu Ser Ala Pro Phe Arg Gln Ala Ala Leu 
    130                 135                 140                 


Arg His Asn Val Ala Pro Ile Phe Ile Cys Pro Pro Asn Ala Asp Asp 
145                 150                 155                 160 


Asp Leu Leu Arg Gln Ile Ala Ser Tyr Gly Arg Gly Tyr Thr Tyr Leu 
                165                 170                 175     


Leu Ser Arg Ala Gly Val Thr Gly Ala Glu Asn Arg Ala Ala Leu Pro 
            180                 185                 190         


Leu Asn His Leu Val Ala Lys Leu Lys Glu Tyr Asn Ala Ala Pro Pro 
        195                 200                 205             


Leu Gln Gly Phe Gly Ile Ser Ala Pro Asp Gln Val Lys Ala Ala Ile 
    210                 215                 220                 


Asp Ala Gly Ala Ala Gly Ala Ile Ser Gly Ser Ala Ile Val Lys Ile 
225                 230                 235                 240 


Ile Glu Gln His Ile Asn Glu Pro Glu Lys Met Leu Ala Ala Leu Lys 
                245                 250                 255     


Ala Phe Val Gln Pro Met Lys Ala Ala Thr Arg Ser 
            260                 265             


<210> 19
<211> 350
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Asn Tyr Gln Asn Asp Asp Leu Arg Ile Lys Glu Ile Lys Glu Leu 
1               5                   10                  15      


Leu Pro Pro Val Ala Leu Leu Glu Lys Phe Pro Ala Thr Glu Asn Ala 
            20                  25                  30          


Ala Asn Thr Val Ala His Ala Arg Lys Ala Ile His Lys Ile Leu Lys 
        35                  40                  45              


Gly Asn Asp Asp Arg Leu Leu Val Val Ile Gly Pro Cys Ser Ile His 
    50                  55                  60                  


Asp Pro Val Ala Ala Lys Glu Tyr Ala Thr Arg Leu Leu Thr Leu Arg 
65                  70                  75                  80  


Glu Glu Leu Gln Asp Glu Leu Glu Ile Val Met Arg Val Tyr Phe Glu 
                85                  90                  95      


Lys Pro Arg Thr Thr Val Gly Trp Lys Gly Leu Ile Asn Asp Pro His 
            100                 105                 110         


Met Asp Asn Ser Phe Gln Ile Asn Asp Gly Leu Arg Ile Ala Arg Lys 
        115                 120                 125             


Leu Leu Leu Asp Ile Asn Asp Ser Gly Leu Pro Ala Ala Gly Glu Phe 
    130                 135                 140                 


Leu Asp Met Ile Thr Leu Gln Tyr Leu Ala Asp Leu Met Ser Trp Gly 
145                 150                 155                 160 


Ala Ile Gly Ala Arg Thr Thr Glu Ser Gln Val His Arg Glu Leu Ala 
                165                 170                 175     


Ser Gly Leu Ser Cys Pro Val Gly Phe Lys Asn Gly Thr Asp Gly Thr 
            180                 185                 190         


Ile Lys Val Ala Ile Asp Ala Ile Asn Ala Ala Gly Ala Pro His Cys 
        195                 200                 205             


Phe Leu Ser Val Thr Lys Trp Gly His Ser Ala Ile Val Asn Thr Ser 
    210                 215                 220                 


Gly Asn Gly Asp Cys His Ile Ile Leu Arg Gly Gly Lys Glu Pro Asn 
225                 230                 235                 240 


Tyr Ser Ala Lys His Val Ala Glu Val Lys Glu Gly Leu Asn Lys Ala 
                245                 250                 255     


Gly Leu Pro Ala Gln Val Met Ile Asp Phe Ser His Ala Asn Ser Ser 
            260                 265                 270         


Lys Gln Phe Lys Lys Gln Met Asp Val Cys Thr Asp Val Cys Gln Gln 
        275                 280                 285             


Ile Ala Gly Gly Glu Lys Ala Ile Ile Gly Val Met Val Glu Ser His 
    290                 295                 300                 


Leu Val Glu Gly Asn Gln Ser Leu Glu Ser Gly Glu Pro Leu Ala Tyr 
305                 310                 315                 320 


Gly Lys Ser Ile Thr Asp Ala Cys Ile Gly Trp Asp Asp Thr Asp Ala 
                325                 330                 335     


Leu Leu Arg Gln Leu Ala Ser Ala Val Lys Ala Arg Arg Gly 
            340                 345                 350 


<210> 20
<211> 353
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Leu Leu Phe Glu Thr Val Arg Glu Met Gly His Glu Gln Val Leu 
1               5                   10                  15      


Phe Cys His Ser Lys Asn Pro Glu Ile Lys Ala Ile Ile Ala Ile His 
            20                  25                  30          


Asp Thr Thr Leu Gly Pro Ala Met Gly Ala Thr Arg Ile Leu Pro Tyr 
        35                  40                  45              


Ile Asn Glu Glu Ala Ala Leu Lys Asp Ala Leu Arg Leu Ser Arg Gly 
    50                  55                  60                  


Met Thr Tyr Lys Ala Ala Cys Ala Asn Ile Pro Ala Gly Gly Gly Lys 
65                  70                  75                  80  


Ala Val Ile Ile Ala Asn Pro Glu Asn Lys Thr Asp Asp Leu Leu Arg 
                85                  90                  95      


Ala Tyr Gly Arg Phe Val Asp Ser Leu Asn Gly Arg Phe Ile Thr Gly 
            100                 105                 110         


Gln Asp Val Asn Ile Thr Pro Asp Asp Val Arg Thr Ile Ser Gln Glu 
        115                 120                 125             


Thr Lys Tyr Val Val Gly Val Ser Glu Lys Ser Gly Gly Pro Ala Pro 
    130                 135                 140                 


Ile Thr Ser Leu Gly Val Phe Leu Gly Ile Lys Ala Ala Val Glu Ser 
145                 150                 155                 160 


Arg Trp Gln Ser Lys Arg Leu Asp Gly Met Lys Val Ala Val Gln Gly 
                165                 170                 175     


Leu Gly Asn Val Gly Lys Asn Leu Cys Arg His Leu His Glu His Asp 
            180                 185                 190         


Val Gln Leu Phe Val Ser Asp Val Asp Pro Ile Lys Ala Glu Glu Val 
        195                 200                 205             


Lys Arg Leu Phe Gly Ala Thr Val Val Glu Pro Thr Glu Ile Tyr Ser 
    210                 215                 220                 


Leu Asp Val Asp Ile Phe Ala Pro Cys Ala Leu Gly Gly Ile Leu Asn 
225                 230                 235                 240 


Ser His Thr Ile Pro Phe Leu Gln Ala Ser Ile Ile Ala Gly Ala Ala 
                245                 250                 255     


Asn Asn Gln Leu Glu Asn Glu Gln Leu His Ser Gln Met Leu Ala Lys 
            260                 265                 270         


Lys Gly Ile Leu Tyr Ser Pro Asp Tyr Val Ile Asn Ala Gly Gly Leu 
        275                 280                 285             


Ile Asn Val Tyr Asn Glu Met Ile Gly Tyr Asp Glu Glu Lys Ala Phe 
    290                 295                 300                 


Lys Gln Val His Asn Ile Tyr Asp Thr Leu Leu Ala Ile Phe Glu Ile 
305                 310                 315                 320 


Ala Lys Glu Gln Gly Val Thr Thr Asn Asp Ala Ala Arg Arg Leu Ala 
                325                 330                 335     


Glu Asp Arg Ile Asn Asn Ser Lys Arg Ser Lys Ser Lys Ala Ile Ala 
            340                 345                 350         


Ala 
    


<210> 21
<211> 552
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Arg Thr Pro Tyr Cys Val Ala Asp Tyr Leu Leu Asp Arg Leu Thr 
1               5                   10                  15      


Asp Cys Gly Ala Asp His Leu Phe Gly Val Pro Gly Asp Tyr Asn Leu 
            20                  25                  30          


Gln Phe Leu Asp His Val Ile Asp Ser Pro Asp Ile Cys Trp Val Gly 
        35                  40                  45              


Cys Ala Asn Glu Leu Asn Ala Ser Tyr Ala Ala Asp Gly Tyr Ala Arg 
    50                  55                  60                  


Cys Lys Gly Phe Ala Ala Leu Leu Thr Thr Phe Gly Val Gly Glu Leu 
65                  70                  75                  80  


Ser Ala Met Asn Gly Ile Ala Gly Ser Tyr Ala Glu His Val Pro Val 
                85                  90                  95      


Leu His Ile Val Gly Ala Pro Gly Thr Ala Ala Gln Gln Arg Gly Glu 
            100                 105                 110         


Leu Leu His His Thr Leu Gly Asp Gly Glu Phe Arg His Phe Tyr His 
        115                 120                 125             


Met Ser Glu Pro Ile Thr Val Ala Gln Ala Val Leu Thr Glu Gln Asn 
    130                 135                 140                 


Ala Cys Tyr Glu Ile Asp Arg Val Leu Thr Thr Met Leu Arg Glu Arg 
145                 150                 155                 160 


Arg Pro Gly Tyr Leu Met Leu Pro Ala Asp Val Ala Lys Lys Ala Ala 
                165                 170                 175     


Thr Pro Pro Val Asn Ala Leu Thr His Lys Gln Ala His Ala Asp Ser 
            180                 185                 190         


Ala Cys Leu Lys Ala Phe Arg Asp Ala Ala Glu Asn Lys Leu Ala Met 
        195                 200                 205             


Ser Lys Arg Thr Ala Leu Leu Ala Asp Phe Leu Val Leu Arg His Gly 
    210                 215                 220                 


Leu Lys His Ala Leu Gln Lys Trp Val Lys Glu Val Pro Met Ala His 
225                 230                 235                 240 


Ala Thr Met Leu Met Gly Lys Gly Ile Phe Asp Glu Arg Gln Ala Gly 
                245                 250                 255     


Phe Tyr Gly Thr Tyr Ser Gly Ser Ala Ser Thr Gly Ala Val Lys Glu 
            260                 265                 270         


Ala Ile Glu Gly Ala Asp Thr Val Leu Cys Val Gly Thr Arg Phe Thr 
        275                 280                 285             


Asp Thr Leu Thr Ala Gly Phe Thr His Gln Leu Thr Pro Ala Gln Thr 
    290                 295                 300                 


Ile Glu Val Gln Pro His Ala Ala Arg Val Gly Asp Val Trp Phe Thr 
305                 310                 315                 320 


Gly Ile Pro Met Asn Gln Ala Ile Glu Thr Leu Val Glu Leu Cys Lys 
                325                 330                 335     


Gln His Val His Ala Gly Leu Met Ser Ser Ser Ser Gly Ala Ile Pro 
            340                 345                 350         


Phe Pro Gln Pro Asp Gly Ser Leu Thr Gln Glu Asn Phe Trp Arg Thr 
        355                 360                 365             


Leu Gln Thr Phe Ile Arg Pro Gly Asp Ile Ile Leu Ala Asp Gln Gly 
    370                 375                 380                 


Thr Ser Ala Phe Gly Ala Ile Asp Leu Arg Leu Pro Ala Asp Val Asn 
385                 390                 395                 400 


Phe Ile Val Gln Pro Leu Trp Gly Ser Ile Gly Tyr Thr Leu Ala Ala 
                405                 410                 415     


Ala Phe Gly Ala Gln Thr Ala Cys Pro Asn Arg Arg Val Ile Val Leu 
            420                 425                 430         


Thr Gly Asp Gly Ala Ala Gln Leu Thr Ile Gln Glu Leu Gly Ser Met 
        435                 440                 445             


Leu Arg Asp Lys Gln His Pro Ile Ile Leu Val Leu Asn Asn Glu Gly 
    450                 455                 460                 


Tyr Thr Val Glu Arg Ala Ile His Gly Ala Glu Gln Arg Tyr Asn Asp 
465                 470                 475                 480 


Ile Ala Leu Trp Asn Trp Thr His Ile Pro Gln Ala Leu Ser Leu Asp 
                485                 490                 495     


Pro Gln Ser Glu Cys Trp Arg Val Ser Glu Ala Glu Gln Leu Ala Asp 
            500                 505                 510         


Val Leu Glu Lys Val Ala His His Glu Arg Leu Ser Leu Ile Glu Val 
        515                 520                 525             


Met Leu Pro Lys Ala Asp Ile Pro Pro Leu Leu Gly Ala Leu Thr Lys 
    530                 535                 540                 


Ala Leu Glu Ala Cys Asn Asn Ala 
545                 550         


<210> 22
<211> 497
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Pro Thr Leu Asn Leu Asp Leu Pro Asn Gly Ile Lys Ser Thr Ile 
1               5                   10                  15      


Gln Ala Asp Leu Phe Ile Asn Asn Lys Phe Val Pro Ala Leu Asp Gly 
            20                  25                  30          


Lys Thr Phe Ala Thr Ile Asn Pro Ser Thr Gly Lys Glu Ile Gly Gln 
        35                  40                  45              


Val Ala Glu Ala Ser Ala Lys Asp Val Asp Leu Ala Val Lys Ala Ala 
    50                  55                  60                  


Arg Glu Ala Phe Glu Thr Thr Trp Gly Glu Asn Thr Pro Gly Asp Ala 
65                  70                  75                  80  


Arg Gly Arg Leu Leu Ile Lys Leu Ala Glu Leu Val Glu Ala Asn Ile 
                85                  90                  95      


Asp Glu Leu Ala Ala Ile Glu Ser Leu Asp Asn Gly Lys Ala Phe Ser 
            100                 105                 110         


Ile Ala Lys Ser Phe Asp Val Ala Ala Val Ala Ala Asn Leu Arg Tyr 
        115                 120                 125             


Tyr Gly Gly Trp Ala Asp Lys Asn His Gly Lys Val Met Glu Val Asp 
    130                 135                 140                 


Thr Lys Arg Leu Asn Tyr Thr Arg His Glu Pro Ile Gly Val Cys Gly 
145                 150                 155                 160 


Gln Ile Ile Pro Trp Asn Phe Pro Leu Leu Met Phe Ala Trp Lys Leu 
                165                 170                 175     


Gly Pro Ala Leu Ala Thr Gly Asn Thr Ile Val Leu Lys Thr Ala Glu 
            180                 185                 190         


Gln Thr Pro Leu Ser Ala Ile Lys Met Cys Glu Leu Ile Val Glu Ala 
        195                 200                 205             


Gly Phe Pro Pro Gly Val Val Asn Val Ile Ser Gly Phe Gly Pro Val 
    210                 215                 220                 


Ala Gly Ala Ala Ile Ser Gln His Met Asp Ile Asp Lys Ile Ala Phe 
225                 230                 235                 240 


Thr Gly Ser Thr Leu Val Gly Arg Asn Ile Met Lys Ala Ala Ala Ser 
                245                 250                 255     


Thr Asn Leu Lys Lys Val Thr Leu Glu Leu Gly Gly Lys Ser Pro Asn 
            260                 265                 270         


Ile Ile Phe Lys Asp Ala Asp Leu Asp Gln Ala Val Arg Trp Ser Ala 
        275                 280                 285             


Phe Gly Ile Met Phe Asn His Gly Gln Cys Cys Cys Ala Gly Ser Arg 
    290                 295                 300                 


Val Tyr Val Glu Glu Ser Ile Tyr Asp Ala Phe Met Glu Lys Met Thr 
305                 310                 315                 320 


Ala His Cys Lys Ala Leu Gln Val Gly Asp Pro Phe Ser Ala Asn Thr 
                325                 330                 335     


Phe Gln Gly Pro Gln Val Ser Gln Leu Gln Tyr Asp Arg Ile Met Glu 
            340                 345                 350         


Tyr Ile Glu Ser Gly Lys Lys Asp Ala Asn Leu Ala Leu Gly Gly Val 
        355                 360                 365             


Arg Lys Gly Asn Glu Gly Tyr Phe Ile Glu Pro Thr Ile Phe Thr Asp 
    370                 375                 380                 


Val Pro His Asp Ala Lys Ile Ala Lys Glu Glu Ile Phe Gly Pro Val 
385                 390                 395                 400 


Val Val Val Ser Lys Phe Lys Asp Glu Lys Asp Leu Ile Arg Ile Ala 
                405                 410                 415     


Asn Asp Ser Ile Tyr Gly Leu Ala Ala Ala Val Phe Ser Arg Asp Ile 
            420                 425                 430         


Ser Arg Ala Ile Glu Thr Ala His Lys Leu Lys Ala Gly Thr Val Trp 
        435                 440                 445             


Val Asn Cys Tyr Asn Gln Leu Ile Pro Gln Val Pro Phe Gly Gly Tyr 
    450                 455                 460                 


Lys Ala Ser Gly Ile Gly Arg Glu Leu Gly Glu Tyr Ala Leu Ser Asn 
465                 470                 475                 480 


Tyr Thr Asn Ile Lys Ala Val His Val Asn Leu Ser Gln Pro Ala Pro 
                485                 490                 495     


Ile 
    


<210> 23
<211> 169
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
agttgttctt attggtggtg ttgctttatg gttgcatcgt agtaaatggt tgtaacaaaa       60

gcaatttttc cggctgtctg tatacaaaaa cgccgcaaag tttgagcgaa gtcaataaac      120

tctctaccca ttcagggcaa tatctctctt ggatccaaag tgaacccgc                  169


