                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Gibbons, Garrett S
       Riddle, Dawn M
       Trojanowski, John Q
       Lee, Virginia M Y
 
<120>  Monoclonal antibodies against pathological conformation of tau 
       protein

<130>  046483-7306WO1(02579)

<150>  US 63/029,977
<151>  2020-05-26

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  1
gaggttcagc tgcagcagtc tggggcagag cttgtgaggt caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa                                        90


<210>  2
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  2
gactactata tgcac                                                        15


<210>  3
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  3
tgggttaagc agaggcctga acagggcctg gagtggattg ga                          42


<210>  4
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  4
tggtttgatc ctgagaatgg tgatgctgaa tatgccccga agttccagga c                51


<210>  5
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  5
aaggccacta tgactgcaga cacatcctcc aacgcagcct acctgcagct cagcagcctg       60

acatctgagg acactgccgt ctattactgt aatggt                                 96


<210>  6
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  6
tatctttac                                                                9


<210>  7
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  7
tggggccaag ggactctggt cactgtctct tca                                    33


<210>  8
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  8

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys 
            20                  25                  30  


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  9

Asp Tyr Tyr Met His 
1               5   


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  10

Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  11

Trp Phe Asp Pro Glu Asn Gly Asp Ala Glu Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  12
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  12

Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Ala Ala Tyr Leu Gln 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Asn Gly 
            20                  25                  30          


<210>  13
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  13

Tyr Leu Tyr 
1           


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  14

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  15
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgc                                                               69


<210>  16
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  16
agatctagtc agaacattgt acataataat ggaaacacct atttagaa                    48


<210>  17
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  17
tggtaccttc agaaaccagg ccagtctcca aagctcctga tctac                       45


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  18
aaagtttcca accgattttc t                                                 21


<210>  19
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  19
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc       60

agagtggagg ctgaggatct gggaatttat tactgc                                 96


<210>  20
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  20
tttcaaggtt cacatgttcc gcacacg                                           27


<210>  21
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  21
ttcggagggg ggaccaggct ggaaataaaa                                        30


<210>  22
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  22

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  23

Arg Ser Ser Gln Asn Ile Val His Asn Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  24
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  24

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  25

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  26
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  26

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  27

Phe Gln Gly Ser His Val Pro His Thr 
1               5                   


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  28

Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  29
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  29
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctggggcttc agtgaaactg       60

tcctgcaagg cttct                                                        75


<210>  30
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  30
ggctacatct tcaccaccta ctgg                                              24


<210>  31
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  31
atgaactggg tgaagcagag gcctggacag ggccttgaat ggattgctat g                51


<210>  32
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  32
attgatcctt cagacagtga aact                                              24


<210>  33
<211>  111
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  33
cactacaatc aaatgttcaa ggacaaggcc acattgactg tagacacatc ctccagcacg       60

gcctacatgc agctcagcgg cctgacatct gaagactctg cggtctatta c               111


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  34
tgtgcaagag gggaaggcta ctgg                                              24


<210>  35
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  35
ggccaaggca ccactctcac agtctcctca                                        30


<210>  36
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  36

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser 
            20                  25  


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  37

Gly Tyr Ile Phe Thr Thr Tyr Trp 
1               5               


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  38

Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Ala 
1               5                   10                  15      


Met 
    


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  39

Ile Asp Pro Ser Asp Ser Glu Thr 
1               5               


<210>  40
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  40

His Tyr Asn Gln Met Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Thr 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr 
        35          


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  41

Cys Ala Arg Gly Glu Gly Tyr Trp 
1               5               


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  42

Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10  


<210>  43
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  43
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagt                                                     78


<210>  44
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  44
cagagcctct tagatagtga tggaaagaca tat                                    33


<210>  45
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  45
ttgaattggt tgttacagag cccaggccag tctccaaagc gcctaatctt c                51


<210>  46
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  46
ctggtgtct                                                                9


<210>  47
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  47
aaactggact ctggagtccc tgacaggttc actggcagtg gatcagggac agatttcaca       60

ctgaaaatca gcagagtgga ggctgaggat ttgggagttt attat                      105


<210>  48
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  48
tgctggcaag gtacacattt tccgtggacg ttc                                    33


<210>  49
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  49
ggtggaggca ccaagctgga aatcaaa                                           27


<210>  50
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  50

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 
            20                  25      


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  51

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  52
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  52

Leu Asn Trp Leu Leu Gln Ser Pro Gly Gln Ser Pro Lys Arg Leu Ile 
1               5                   10                  15      


Phe 
    


<210>  53
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  53

Leu Val Ser 
1           


<210>  54
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  54

Lys Leu Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            20                  25                  30          


Val Tyr Tyr 
        35  


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  55

Cys Trp Gln Gly Thr His Phe Pro Trp Thr Phe 
1               5                   10      


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  56

Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   


<210>  57
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  57
gaggttcagc tgcagcagtc tggggcagag cttgtgaggt caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gactactata tgcactgggt taagcagagg      120

cctgaacagg gcctggagtg gattggatgg tttgatcctg agaatggtga tgctgaatat      180

gccccgaagt tccaggacaa ggccactatg actgcagaca catcctccaa cgcagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtaa tggttatctt      300

tactggggcc aagggactct ggtcactgtc tcttca                                336


<210>  58
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  58

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Phe Asp Pro Glu Asn Gly Asp Ala Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Gly Tyr Leu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  59
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  59
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gaacattgta cataataatg gaaacaccta tttagaatgg      120

taccttcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggaatt tattactgct ttcaaggttc acatgttccg      300

cacacgttcg gaggggggac caggctggaa ataaaa                                336


<210>  60
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  60

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile Val His Asn 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro His Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  61
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  61
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctggggcttc agtgaaactg       60

tcctgcaagg cttctggcta catcttcacc acctactgga tgaactgggt gaagcagagg      120

cctggacagg gccttgaatg gattgctatg attgatcctt cagacagtga aactcactac      180

aatcaaatgt tcaaggacaa ggccacattg actgtagaca catcctccag cacggcctac      240

atgcagctca gcggcctgac atctgaagac tctgcggtct attactgtgc aagaggggaa      300

ggctactggg gccaaggcac cactctcaca gtctcctca                             339


<210>  62
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  62

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  63
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  63
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctcc       60

atctcttgca agtcaagtca gagcctctta gatagtgatg gaaagacata tttgaattgg      120

ttgttacaga gcccaggcca gtctccaaag cgcctaatct tcctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattattgct ggcaaggtac acattttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  64
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  64

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Ser Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Phe Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  65
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  65
atgaaatgca gctgggtcat cttcttcctg atggcagtgg ttataggaat caattca          57


<210>  66
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  66

Met Lys Cys Ser Trp Val Ile Phe Phe Leu Met Ala Val Val Ile Gly 
1               5                   10                  15      


Ile Asn Ser 
            


<210>  67
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  67
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagt          57


<210>  68
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  68

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser 
            


<210>  69
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  69

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


