                         SEQUENCE LISTING

<110>  Indiana University Research and Technology Corp.
       DiMarchi, Richard
       Zhang, Fa
 
<120>  PTH ANALOGS FOR THE TREATMENT OF HYPOPARATHYROIDISM

<130>  32993-338101

<150>  63/030,004
<151>  2020-05-26

<150>  63/033,586
<151>  2020-06-15

<160>  135   

<170>  PatentIn version 3.5

<210>  1
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser 
        35                  40                  45              


Gln Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu 
    50                  55                  60                  


Lys Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys 
65                  70                  75                  80  


Ala Lys Ser Gln 
                


<210>  2
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is any acylated amino acid

<400>  2

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  3
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa at position 34 is any acylated amino acid

<400>  3

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  4
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is isobutyric acid (Aib) or Gly

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is isobutyric acid (Aib) or Asn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is amino isobutyric acid (Aib) or Ser

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa at position 26 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly or Val

<400>  4

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Xaa Xaa His Leu Xaa 
1               5                   10                  15      


Xaa Met Glu Arg Val Glu Trp Leu Arg Xaa Xaa Leu Gln Asp Xaa His 
            20                  25                  30          


<210>  5
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa at position 26 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly or Val

<400>  5

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Xaa His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Xaa Xaa Leu Gln Asp Xaa His 
            20                  25                  30          


<210>  6
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is isobutyric acid (Aib) or Gly

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is isobutyric acid (Aib) or Asn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is amino isobutyric acid (Aib) or Ser

<400>  6

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Xaa Lys His Leu Xaa 
1               5                   10                  15      


Xaa Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


<210>  7
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


<210>  8
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is any acylated amino acid

<400>  8

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa Phe 
        


<210>  9
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  10
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is acylated dLys

<400>  10

Xaa Gly Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  11
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is acylated dLys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is N-methyl Gly

<400>  11

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  12
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is an acylated Lys

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  C-terminal carboxyl group replaced with an amide

<400>  12

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  13
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is acylated dLys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is N-methyl Gly

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa at position 37 is an acylated Lys

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  C-terminal carboxyl group replaced with an amide

<400>  13

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe Xaa 
        35          


<210>  14
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is acylated dLys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is N-methyl Gly

<400>  14

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Gln Phe 
        35      


<210>  15
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is any acylated amino acid

<400>  15

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  16
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is an acylated Lys

<400>  16

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  17
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is acylated dLys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is N-methyl Gly

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is an acylated Lys

<400>  17

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  18
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is an acylated Lys

<400>  18

Ser Val Ser Glu Ile Gln Leu Ala His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  19
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is  dLys

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is an acylated Lys

<400>  19

Xaa Gly Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  20
<211>  85
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Xaa at position 85 is an acylated amino acid

<400>  20

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu Gly Ala Pro Leu Ala Pro Arg Asp Ala Gly Ser 
        35                  40                  45              


Gln Arg Pro Arg Lys Lys Glu Asp Asn Val Leu Val Glu Ser His Glu 
    50                  55                  60                  


Lys Ser Leu Gly Glu Ala Asp Lys Ala Asp Val Asn Val Leu Thr Lys 
65                  70                  75                  80  


Ala Lys Ser Gln Xaa 
                85  


<210>  21
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa at position 38 is an acylated amino acid

<400>  21

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu Xaa 
        35              


<210>  22
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  22

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Gly His 
            20                  25                  30          


<210>  23
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Glu His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


<210>  24
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  24

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Glu Lys Leu Gln Asp Val His 
            20                  25                  30          


<210>  25
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Glu Leu Gln Asp Val His 
            20                  25                  30          


<210>  26
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is any acylated amino acid

<400>  26

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  27
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is an acylated dLys

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is an acylated Lys

<400>  27

Xaa Gly Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  model hexpeptide for prodrug studies


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is His, d-His or N-methyl-His

<400>  28

Xaa Ser Arg Gly Thr Phe 
1               5       


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  model hexpeptide for prodrug studies


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Sarcosine

<400>  29

Lys Xaa His Ser Arg Gly Thr Phe 
1               5               


<210>  30
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is any acylated amino acid

<400>  30

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  31
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  31

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn 
    


<210>  32
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  33
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  33

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val 
        35  


<210>  34
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala 
        35      


<210>  35
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu 
        35          


<210>  36
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu Gly 
        35              


<210>  37
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  37

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu Gly Ala 
        35                  


<210>  38
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa at position 34 is K(gamma-glu-COC16H32CO2H)F-OH

<400>  38

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Xaa 
        


<210>  39
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  39

Ser Arg Arg Leu Lys Arg Ala Val Ser Glu His Gln Leu Leu His Asp 
1               5                   10                  15      


Lys Gly Lys Ser Ile Gln Asp Leu Arg Arg Arg Phe Phe Leu His His 
            20                  25                  30          


Leu Ile Ala Glu Ile His Thr Ala Glu Ile Arg Ala Thr Ser Glu Val 
        35                  40                  45              


Ser Pro Asn Ser Lys Pro Ser Pro Asn Thr Lys Asn His Pro Val Arg 
    50                  55                  60                  


Phe Gly Ser Asp Asp Glu Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys 
65                  70                  75                  80  


Val Glu Thr Tyr Lys Glu Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys 
                85                  90                  95      


Lys Gly Lys Pro Gly Lys Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg 
            100                 105                 110         


Thr Arg Ser Ala Trp Leu Asp Ser Gly Val Thr Gly Ser Gly Leu Glu 
        115                 120                 125             


Gly Asp His Leu Ser Asp Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser 
    130                 135                 140                 


Arg Arg His 
145         


<210>  40
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is dAla that has an amide substituted for the 
       native carboxyl group

<400>  40

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  41
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  41

Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser 
1               5                   10                  15      


Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn 
            20                  25                  30          


Phe 
    


<210>  42
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  42

Gly Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  43
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  44
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is a dLys having its side chain acylated with 
       COC16H32CO2H) via a gamma Glu spacer

<400>  44

Xaa Gly Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  45
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is a dLys having its side chain acylated with 
       COC16H32CO2H via a gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is  Sarcosine (n-methyl Glycine)

<400>  45

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  46
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is a dLys having its side chain acylated with 
       COC16H32CO2H via a gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is  n-isopropyl-Glycine

<400>  46

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  47
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys

<400>  47

Xaa Gly Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  48
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is a Lys having its side chain acylated with 
       COC16H32CO2H) via a gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is  n-isopropyl-Glycine

<400>  48

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  49
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is a dLys having its side chain acylated with 
       COC16H32CO2H) via a gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is  n-isopropyl-Glycine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 is  dSer

<400>  49

Xaa Xaa Xaa Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  50
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is a dLys having its side chain acylated with 
       COC16H32CO2H) via a gamma Glu spacer

<400>  50

Xaa Pro Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  51
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is a Lys having its side chain acylated with 
       COC16H32CO2H) via a gamma Glu spacer

<400>  51

Xaa Pro Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  52
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is a Lys having its side chain acylated with 
       COC16H32CO2H) via a gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is  Sarcosine (n-methyl Glycine)

<400>  52

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  53
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is a Lys having its side chain acylated with 
       COC16H32CO2H) via a gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is  n-methyl-Alanine

<400>  53

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  54
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is a Lys having its side chain acylated with 
       COC16H32CO2H) via a gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is  n-methyl-Alanine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Pipecolic acid (piperidine-2-carboxylic 
       acid)

<400>  54

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe 
        35      


<210>  55
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  55

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Gln Phe 
        


<210>  56
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys that has an amide substituted for the 
       native carboxyl group wherein the side chain is acylated with 
       COC16H32CO2H via a gamma Glu spacer

<400>  56

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  57
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Sarcosine (n-methyl-Glysine)

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa at position 37 is Lys that has an amide substituted for the 
       native carboxyl group wherein the side chain is acylated with 
       COC16H32CO2H via a gamma Glu spacer

<400>  57

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe Xaa 
        35          


<210>  58
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Sarcosine (n-methyl-Glysine)

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa at position 37 is Lys that has an amide substituted for the 
       native carboxyl group wherein th eside chain is acylated with 
       COC16H32CO2H via a gamma Glu spacer

<400>  58

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe Xaa 
        35          


<210>  59
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  59

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn 
    


<210>  60
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is aspartic acid wherein the carboxy terminus 
       is replace with an amide

<400>  60

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  61
<211>  36
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is Sarcosine (n-methyl-Glysine)

<400>  61

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Gln Phe 
        35      


<210>  62
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  62

Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser Met Glu Arg Val 
1               5                   10                  15      


Glu Trp Leu Arg Lys Lys Leu Gln Asp Gly His Asn Phe 
            20                  25                  


<210>  63
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa at position 38 is Lys that has an amide substituted for the 
       native carboxyl group wherein the side chain is acylated with 
       COC16H32CO2H via a gamma Glu spacer

<400>  63

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Val Ala Leu Xaa 
        35              


<210>  64
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu spacer

<400>  64

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Arg His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Arg Arg Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  65
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa at position 37 is Lys that has an amide substituted for the 
       native carboxyl group wherein the side chain is acylated with 
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  65

Xaa Gly Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Asn Phe Xaa 
        35          


<210>  66
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys that has an amide substituted for the 
       native carboxyl group wherein the side chain is acylated with 
       COC16H32CO2H via a gamma Glu spacer

<400>  66

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Glu Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  67
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys that has an amide substituted for the 
       native carboxyl group wherein the side chain is acylated with 
       COC16H32CO2H via a gamma Glu spacer

<400>  67

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Glu Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  68
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys that has an amide substituted for the 
       native carboxyl group wherein the side chain is acylated with 
       COC16H32CO2H via a gamma Glu spacer

<400>  68

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Glu His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  69
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is Aib

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys that has an amide substituted for the 
       native carboxyl group wherein the side chain is acylated with 
       COC16H32CO2H via a gamma Glu spacer

<400>  69

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Xaa Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  70
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is Aib

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys that has an amide substituted for the 
       native carboxyl group wherein the side chain is acylated with 
       COC16H32CO2H via a gamma Glu spacer

<400>  70

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Xaa Met Glu Arg Val Glu Trp Leu Arg His Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  71
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is Aib

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys that has an amide substituted for the 
       native carboxyl group wherein the side chain is acylated with 
       COC16H32CO2H via a gamma Glu spacer

<400>  71

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Xaa 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  72
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is Aib

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys that has an amide substituted for the 
       native carboxyl group wherein the side chain is acylated with 
       COC16H32CO2H via a gamma Glu spacer

<400>  72

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Xaa Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe Xaa 
        35  


<210>  73
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu spacer

<400>  73

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Glu His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Glu Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa Phe 
        


<210>  74
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu spacer

<400>  74

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Glu His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Glu Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  75
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu spacer

<400>  75

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Xaa Lys Leu Gln Asp Val His 
            20                  25                  30          


Gln 
    


<210>  76
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a (gamma Glu)3x spacer

<400>  76

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Glu His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Glu Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  77
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 35 is Lys wherein the side 3hain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  77

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  78
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  78

Xaa Gly Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  79
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  79

Xaa Gly Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  80
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position2 is Sarcosine (n-methyl-Glycine)

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  80

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  81
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position2 is n-isopropylGlycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  81

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  82
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Aib

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position2 is n-imethyl-Glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  82

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  83
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side 3hain is acylated with
       COC16H32CO2H via a lysine-gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  83

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  84
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  84

Xaa Gly Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  85
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COCH3

<400>  85

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  86
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC15CH31 via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  86

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  87
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  87

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  88
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  88

Ser Val Ser Glu Ile Gln Ala Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Lys 
    


<210>  89
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  89

Ser Val Ser Glu Ile Gln Leu Ala His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Lys 
    


<210>  90
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  90

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Ala Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn 
    


<210>  91
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  91

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Ala Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Lys 
    


<210>  92
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  92

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Ala Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Lys 
    


<210>  93
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  93

Ser Val Ser Glu Ile Gln Leu Ala His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  94
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  94

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Ala His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  95
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  95

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Ala His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  96
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa at position 38 is an acylated amino acid

<400>  96

Val Ser Glu His Gln Leu Leu His Asp Lys Gly Lys Ser Ile Gln Asp 
1               5                   10                  15      


Leu Arg Arg Arg Phe Phe Leu His His Leu Ile Ala Glu Ile His Thr 
            20                  25                  30          


Ala Glu Ile Arg Ala Xaa 
        35              


<210>  97
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  97

Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser Met 
1               5                   10                  15      


Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His Asn Phe 
            20                  25                  30          


<210>  98
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  98

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  99
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  99

Gln Leu Met His Asn Leu Gly Lys His Leu Asn Ser Met Glu Arg Val 
1               5                   10                  15      


Glu Trp Leu Arg Glu Lys Leu Gln Asp Val His Asn Phe 
            20                  25                  


<210>  100
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  100

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Glu Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  101
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  101

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Glu Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  102
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu spacer

<400>  102

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa Phe 
        


<210>  103
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is amino isobutyric acid (Aib) or Gly

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is amino isobutyric acid (Aib) or Asn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 16 is amino isobutyric acid (Aib) or Ser

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa at position 26 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly or Val

<400>  103

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Xaa Xaa His Leu Xaa 
1               5                   10                  15      


Xaa Met Glu Arg Val Glu Trp Leu Arg Xaa Xaa Leu Gln Asp Xaa His 
            20                  25                  30          


Asn 
    


<210>  104
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa at position 26 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is is Gly or Val

<400>  104

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Xaa His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Xaa Xaa Leu Gln Asp Xaa His 
            20                  25                  30          


Asn 
    


<210>  105
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa a position 16 is amino isobutyric acid (Aib) or Gly

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa a position 16 is amino isobutyric acid (Aib) or Asn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa a position 17 is amino isobutyric acid (Aib) or Ser

<400>  105

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Xaa Lys His Leu Xaa 
1               5                   10                  15      


Xaa Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn 
    


<210>  106
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  106

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn 
    


<210>  107
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Lys  wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  107

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Ala His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  108
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Lys  wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  108

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  109
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is Met wherein the side chain is oxidized to 
       form a sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  109

Ser Val Ser Glu Ile Gln Leu Xaa His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  110
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Met wherein the side chain is oxidized to 
       form a sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  110

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Xaa Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  111
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a Tyr(OPO3H2)-(miniPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(miniPEG)2-gamma Glu spacer

<400>  111

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  112
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a homoCysr(SO3H)-(miniPEG)2-gamma Glu 
       spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(miniPEG)2-gamma Glu spacer

<400>  112

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  113
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a Arg-(miniPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(miniPEG)2-gamma Glu spacer

<400>  113

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  114
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a 
       Arg-(miniPEG)2-Tyr(OPO3H2)-(miniPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(miniPEG)2-gamma Glu spacer

<400>  114

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  115
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a 
       Tyr(OPO3H2)-(miniPEG)2-Tyr(OPO3H2)-(miniPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(miniPEG)2-gamma Glu spacer

<400>  115

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  116
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Lys  wherein the side chain is acylated with
       COC16H32CO2H via a Tyr(OPO3H2)-(miniPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a Tyr(OPO3H2)-gamma Glu-(miniPEG)2-gamma Glu 
       spacer

<400>  116

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  117
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Lys  wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  117

Xaa Xaa Ser Val Ser Glu Ile Glu Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  118
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  118

Ser Val Ser Glu Ile Glu Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  119
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Lys  wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  119

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asp Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  120
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  120

Ser Val Ser Glu Ile Gln Leu Met His Asp Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  121
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Lys  wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  121

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asp Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  122
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  122

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asp 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  123
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is Lys  wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  123

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Glu Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  124
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa at position 33 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  124

Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Glu Asp Val His 
            20                  25                  30          


Xaa 
    


<210>  125
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is iso-aspartic acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  125

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Xaa Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  126
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is iso-aspartic acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  126

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Xaa Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  127
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is Met wherein the side chain is oxidized to 
       form a sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  127

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Xaa His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  128
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is Met wherein the side chain is oxidized to 
       form a sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  128

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Xaa Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  129
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  129

Ser Val Ser Glu Ile Gln Leu Met His Ala Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  130
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  130

Ser Val Ser Glu Ile Gln Leu Met His Phe Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  131
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  131

Ser Val Ser Glu Ile Gln Leu Met His Trp Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210>  132
<211>  35
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is dLys  wherein the side chain is acylated 
       with COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is n-methyl glycine

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa at position 20 is Met wherein the side chain is oxidized to 
       form a sulfoxide

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa at position 35 is Lys wherein the side chain is acylated with
       COC16H32CO2H via a gamma Glu-(MINIPEG)2-gamma Glu spacer

<400>  132

Xaa Xaa Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His 
1               5                   10                  15      


Leu Asn Ser Met Glu Arg Val Val Trp Leu Arg Lys Lys Leu Gln Asp 
            20                  25                  30          


Val His Xaa 
        35  


<210>  133
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is Asp, Gln or Asn

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at position 13 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is Asp, Gln or Asn

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Met, Met(O), Leu, or Nleu

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa at position 26 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa at position 27 is Arg, Glu, Asp or Lys

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa at position 31 is Gly or Val

<400>  133

Ser Val Ser Glu Ile Gln Leu Met His Xaa Leu Gly Xaa His Leu Xaa 
1               5                   10                  15      


Ser Xaa Glu Arg Val Glu Trp Leu Arg Xaa Xaa Leu Gln Asp Xaa His 
            20                  25                  30          


<210>  134
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is Asp, Gln or Asn

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa at position 12 is isobutyric acid (Aib) or Gly

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is isobutyric acid (Aib) or Asn

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa at position 17 is amino isobutyric acid (Aib) or Ser

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Met, Met(O), Leu, or Nleu

<400>  134

Ser Val Ser Glu Ile Gln Leu Met His Xaa Leu Xaa Lys His Leu Xaa 
1               5                   10                  15      


Xaa Xaa Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


<210>  135
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is Asp, Gln or Asn

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa at position 16 is Asp, Gln or Asn

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa at position 18 is Met, Met(O), Leu, or Nleu

<400>  135

Ser Val Ser Glu Ile Gln Leu Met His Xaa Leu Gly Lys His Leu Xaa 
1               5                   10                  15      


Ser Xaa Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


