                         SEQUENCE LISTING

<110>  PTC Therapeutics, Inc.
       
	Weetall, Marla
	Jin Zhuo 
	Jana Narasimhan
	Welch, Ellen
       
 
<120>  QUANTIFICATION OF DYSTROPHIN

<130>  P1593-WO

<150>  63/030,109
<151>  2020-05-26

<160>  12     

<170>  PatentIn version 3.5

<210>  1
<211>  11055
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctttggt gggaagaagt agaggactgt tatgaaagag aagatgttca aaagaaaaca       60

ttcacaaaat gggtaaatgc acaattttct aagtttggga agcagcatat tgagaacctc      120

ttcagtgacc tacaggatgg gaggcgcctc ctagacctcc tcgaaggcct gacagggcaa      180

aaactgccaa aagaaaaagg atccacaaga gttcatgccc tgaacaatgt caacaaggca      240

ctgcgggttt tgcagaacaa taatgttgat ttagtgaata ttggaagtac tgacatcgta      300

gatggaaatc ataaactgac tcttggtttg atttggaata taatcctcca ctggcaggtc      360

aaaaatgtaa tgaaaaatat catggctgga ttgcaacaaa ccaacagtga aaagattctc      420

ctgagctggg tccgacaatc aactcgtaat tatccacagg ttaatgtaat caacttcacc      480

accagctggt ctgatggcct ggctttgaat gctctcatcc atagtcatag gccagaccta      540

tttgactgga atagtgtggt ttgccagcag tcagccacac aacgactgga acatgcattc      600

aacatcgcca gatatcaatt aggcatagag aaactactcg atcctgaaga tgttgatacc      660

acctatccag ataagaagtc catcttaatg tacatcacat cactcttcca agttttgcct      720

caacaagtga gcattgaagc catccaggaa gtggaaatgt tgccaaggcc acctaaagtg      780

actaaagaag aacattttca gttacatcat caaatgcact attctcaaca gatcacggtc      840

agtctagcac agggatatga gagaacttct tcccctaagc ctcgattcaa gagctatgcc      900

tacacacagg ctgcttatgt caccacctct gaccctacac ggagcccatt tccttcacag      960

catttggaag ctcctgaaga caagtcattt ggcagttcat tgatggagag tgaagtaaac     1020

ctggaccgtt atcaaacagc tttagaagaa gtattatcgt ggcttctttc tgctgaggac     1080

acattgcaag cacaaggaga gatttctaat gatgtggaag tggtgaaaga ccagtttcat     1140

actcatgagg ggtacatgat ggatttgaca gcccatcagg gccgggttgg taatattcta     1200

caattgggaa gtaagctgat tggaacagga aaattatcag aagatgaaga aactgaagta     1260

caagagcaga tgaatctcct aaattcaaga tgggaatgcc tcagggtagc tagcatggaa     1320

aaacaaagca atttacatag agttttaatg gatctccaga atcagaaact gaaagagttg     1380

aatgactggc taacaaaaac agaagaaaga acaaggaaaa tggaggaaga gcctcttgga     1440

cctgatcttg aagacctaaa acgccaagta caacaacata aggtgcttca agaagatcta     1500

gaacaagaac aagtcagggt caattctctc actcacatgg tggtggtagt tgatgaatct     1560

agtggagatc acgcaactgc tgctttggaa gaacaactta aggtattggg agatcgatgg     1620

gcaaacatct gtagatggac agaagaccgc tgggttcttt tacaagacat ccttctcaaa     1680

tggcaacgtc ttactgaaga acagtgcctt tttagtgcat ggctttcaga aaaagaagat     1740

gcagtgaaca agattcacac aactggcttt aaagatcaaa atgaaatgtt atcaagtctt     1800

caaaaactgg ccgttttaaa agcggatcta gaaaagaaaa agcaatccat gggcaaactg     1860

tattcactca aacaagatct tctttcaaca ctgaagaata agtcagtgac ccagaagacg     1920

gaagcatggc tggataactt tgcccggtgt tgggataatt tagtccaaaa acttgaaaag     1980

agtacagcac agatttcaca ggctgtcacc accactcagc catcactaac acagacaact     2040

gtaatggaaa cagtaactac ggtgaccaca agggaacaga tcctggtaaa gcatgctcaa     2100

gaggaacttc caccaccacc tccccaaaag aagaggcaga ttactgtgga ttctgaaatt     2160

aggaaaaggt tggatgttga tataactgaa cttcacagct ggattactcg ctcagaagct     2220

gtgttgcaga gtcctgaatt tgcaatcttt cggaaggaag gcaacttctc agacttaaaa     2280

gaaaaagtca atgccataga gcgagaaaaa gctgagaagt tcagaaaact gcaagatgcc     2340

agcagatcag ctcaggccct ggtggaacag atggtgaatg agggtgttaa tgcagatagc     2400

atcaaacaag cctcagaaca actgaacagc cggtggatcg aattctgcca gttgctaagt     2460

gagagactta actggctgga gtatcagaac aacatcatcg ctttctataa tcagctacaa     2520

caattggagc agatgacaac tactgctgaa aactggttga aaatccaacc caccacccca     2580

tcagagccaa cagcaattaa aagtcagtta aaaatttgta aggatgaagt caaccggcta     2640

tcaggtcttc aacctcaaat tgaacgatta aaaattcaaa gcatagccct gaaagagaaa     2700

ggacaaggac ccatgttcct ggatgcagac tttgtggcct ttacaaatca ttttaagcaa     2760

gtcttttctg atgtgcaggc cagagagaaa gagctacaga caatttttga cactttgcca     2820

ccaatgcgct atcaggagac catgagtgcc atcaggacat gggtccagca gtcagaaacc     2880

aaactctcca tacctcaact tagtgtcacc gactatgaaa tcatggagca gagactcggg     2940

gaattgcagg ctttacaaag ttctctgcaa gagcaacaaa gtggcctata ctatctcagc     3000

accactgtga aagagatgtc gaagaaagcg ccctctgaaa ttagccggaa atatcaatca     3060

gaatttgaag aaattgaggg acgctggaag aagctctcct cccagctggt tgagcattgt     3120

caaaagctag aggagcaaat gaataaactc cgaaaaattc agaatcacat acaaaccctg     3180

aagaaatgga tggctgaagt tgatgttttt ctgaaggagg aatggcctgc ccttggggat     3240

tcagaaattc taaaaaagca gctgaaacag tgcagacttt tagtcagtga tattcagaca     3300

attcagccca gtctaaacag tgtcaatgaa ggtgggcaga agataaagaa tgaagcagag     3360

ccagagtttg cttcgagact tgagacagaa ctcaaagaac ttaacactca gtgggatcac     3420

atgtgccaac aggtctatgc cagaaaggag gccttgaagg gaggtttgga gaaaactgta     3480

agcctccaga aagatctatc agagatgcac gaatggatga cacaagctga agaagagtat     3540

cttgagagag attttgaata taaaactcca gatgaattac agaaagcagt tgaagagatg     3600

aagagagcta aagaagaggc ccaacaaaaa gaagcgaaag tgaaactcct tactgagtct     3660

gtaaatagtg tcatagctca agctccacct gtagcacaag aggccttaaa aaaggaactt     3720

gaaactctaa ccaccaacta ccagtggctc tgcactaggc tgaatgggaa atgcaagact     3780

ttggaagaag tttgggcatg ttggcatgag ttattgtcat acttggagaa agcaaacaag     3840

tggctaaatg aagtagaatt taaacttaaa accactgaaa acattcctgg cggagctgag     3900

gaaatctctg aggtgctaga ttcacttgaa aatttgatgc gacattcaga ggataaccca     3960

aatcagattc gcatattggc acagacccta acagatggcg gagtcatgga tgagctaatc     4020

aatgaggaac ttgagacatt taattctcgt tggagggaac tacatgaaga ggctgtaagg     4080

aggcaaaagt tgcttgaaca gagcatccag tctgcccagg agactgaaaa atccttacac     4140

ttaatccagg agtccctcac attcattgac aagcagttgg cagcttatat tgcagacaag     4200

gtggacgcag ctcaaatgcc tcaggaagcc cagaaaatcc aatctgattt gacaagtcat     4260

gagatcagtt tagaagaaat gaagaaacat aatcagggga aggaggctgc ccaaagagtc     4320

ctgtctcaga ttgatgttgc acagaaaaaa ttacaagatg tctccatgaa gtttcgatta     4380

ttccagaaac cagccaattt tgagcagcgt ctacaagaaa gtaagatgat tttagatgaa     4440

gtgaagatgc acttgcctgc attggaaaca aagagtgtgg aacaggaagt agtacagtca     4500

cagctaaatc attgtgtgaa cttgtataaa agtctgagtg aagtgaagtc tgaagtggaa     4560

atggtgataa agactggacg tcagattgta cagaaaaagc agacggaaaa tcccaaagaa     4620

cttgatgaaa gagtaacagc tttgaaattg cattataatg agctgggagc aaaggtaaca     4680

gaaagaaagc aacagttgga gaaatgcttg aaattgtccc gtaagatgcg aaaggaaatg     4740

aatgtcttga cagaatggct ggcagctaca gatatggaat tgacaaagag atcagcagtt     4800

gaaggaatgc ctagtaattt ggattctgaa gttgcctggg gaaaggctac tcaaaaagag     4860

attgagaaac agaaggtgca cctgaagagt atcacagagg taggagaggc cttgaaaaca     4920

gttttgggca agaaggagac gttggtggaa gataaactca gtcttctgaa tagtaactgg     4980

atagctgtca cctcccgagc agaagagtgg ttaaatcttt tgttggaata ccagaaacac     5040

atggaaactt ttgaccagaa tgtggaccac atcacaaagt ggatcattca ggctgacaca     5100

cttttggatg aatcagagaa aaagaaaccc cagcaaaaag aagacgtgct taagcgttta     5160

aaggcagaac tgaatgacat acgcccaaag gtggactcta cacgtgacca agcagcaaac     5220

ttgatggcaa accgcggtga ccactgcagg aaattagtag agccccaaat ctcagagctc     5280

aaccatcgat ttgcagccat ttcacacaga attaagactg gaaaggcctc cattcctttg     5340

aaggaattgg agcagtttaa ctcagatata caaaaattgc ttgaaccact ggaggctgaa     5400

attcagcagg gggtgaatct gaaagaggaa gacttcaata aagatatgaa tgaagacaat     5460

gagggtactg taaaagaatt gttgcaaaga ggagacaact tacaacaaag aatcacagat     5520

gagagaaagc gagaggaaat aaagataaaa cagcagctgt tacagacaaa acataatgct     5580

ctcaaggatt tgaggtctca aagaagaaaa aaggctctag aaatttctca tcagtggtat     5640

cagtacaaga ggcaggctga tgatctcctg aaatgcttgg atgacattga aaaaaaatta     5700

gccagcctac ctgagcccag agatgaaagg aaaataaagg aaattgatcg ggaattgcag     5760

aagaagaaag aggagctgaa tgcagtgcgt aggcaagctg agggcttgtc tgaggatggg     5820

gccgcaatgg cagtggagcc aactcagatc cagctcagca agcgctggcg ggaaattgag     5880

agcaaatttg ctcagtttcg aagactcaac tttgcacaaa ttcacactgt ccgtgaagaa     5940

acgatgatgg tgatgactga agacatgcct ttggaaattt cttatgtgcc ttctacttat     6000

ttgactgaaa tcactcatgt ctcacaagcc ctattagaag tggaacaact tctcaatgct     6060

cctgacctct gtgctaagga ctttgaagat ctctttaagc aagaggagtc tctgaagaat     6120

ataaaagata gtctacaaca aagctcaggt cggattgaca ttattcatag caagaagaca     6180

gcagcattgc aaagtgcaac gcctgtggaa agggtgaagc tacaggaagc tctctcccag     6240

cttgatttcc aatgggaaaa agttaacaaa atgtacaagg accgacaagg gcgatttgac     6300

agatctgttg agaaatggcg gcgttttcat tatgatataa agatatttaa tcagtggcta     6360

acagaagctg aacagtttct cagaaagaca caaattcctg agaattggga acatgctaaa     6420

tacaaatggt atcttaagga actccaggat ggcattgggc agcggcaaac tgttgtcaga     6480

acattgaatg caactgggga agaaataatt cagcaatcct caaaaacaga tgccagtatt     6540

ctacaggaaa aattgggaag cctgaatctg cggtggcagg aggtctgcaa acagctgtca     6600

gacagaaaaa agaggctaga agaacaaaag aatatcttgt cagaatttca aagagattta     6660

aatgaatttg ttttatggtt ggaggaagca gataacattg ctagtatccc acttgaacct     6720

ggaaaagagc agcaactaaa agaaaagctt gagcaagtca agttactggt ggaagagttg     6780

cccctgcgcc agggaattct caaacaatta aatgaaactg gaggacccgt gcttgtaagt     6840

gctcccataa gcccagaaga gcaagataaa cttgaaaata agctcaagca gacaaatctc     6900

cagtggataa aggtttccag agctttacct gagaaacaag gagaaattga agctcaaata     6960

aaagaccttg ggcagcttga aaaaaagctt gaagaccttg aagagcagtt aaatcatctg     7020

ctgctgtggt tatctcctat taggaatcag ttggaaattt ataaccaacc aaaccaagaa     7080

ggaccatttg acgttcagga aactgaaata gcagttcaag ctaaacaacc ggatgtggaa     7140

gagattttgt ctaaagggca gcatttgtac aaggaaaaac cagccactca gccagtgaag     7200

aggaagttag aagatctgag ctctgagtgg aaggcggtaa accgtttact tcaagagctg     7260

agggcaaagc agcctgacct agctcctgga ctgaccacta ttggagcctc tcctactcag     7320

actgttactc tggtgacaca acctgtggtt actaaggaaa ctgccatctc caaactagaa     7380

atgccatctt ccttgatgtt ggaggtacct gctctggcag atttcaaccg ggcttggaca     7440

gaacttaccg actggctttc tctgcttgat caagttataa aatcacagag ggtgatggtg     7500

ggtgaccttg aggatatcaa cgagatgatc atcaagcaga aggcaacaat gcaggatttg     7560

gaacagaggc gtccccagtt ggaagaactc attaccgctg cccaaaattt gaaaaacaag     7620

accagcaatc aagaggctag aacaatcatt acggatcgaa ttgaaagaat tcagaatcag     7680

tgggatgaag tacaagaaca ccttcagaac cggaggcaac agttgaatga aatgttaaag     7740

gattcaacac aatggctgga agctaaggaa gaagctgagc aggtcttagg acaggccaga     7800

gccaagcttg agtcatggaa ggagggtccc tatacagtag atgcaatcca aaagaaaatc     7860

acagaaacca agcagttggc caaagacctc cgccagtggc agacaaatgt agatgtggca     7920

aatgacttgg ccctgaaact tctccgggat tattctgcag atgataccag aaaagtccac     7980

atgataacag agaatatcaa tgcctcttgg agaagcattc ataaaagggt gagtgagcga     8040

gaggctgctt tggaagaaac tcatagatta ctgcaacagt tccccctgga cctggaaaag     8100

tttcttgcct ggcttacaga agctgaaaca actgccaatg tcctacagga tgctacccgt     8160

aaggaaaggc tcctagaaga ctccaaggga gtaaaagagc tgatgaaaca atggcaagac     8220

ctccaaggtg aaattgaagc tcacacagat gtttatcaca acctggatga aaacagccaa     8280

aaaatcctga gatccctgga aggttccgat gatgcagtcc tgttacaaag acgtttggat     8340

aacatgaact tcaagtggag tgaacttcgg aaaaagtctc tcaacattag gtcccatttg     8400

gaagccagtt ctgaccagtg gaagcgtctg cacctttctc tgcaggaact tctggtgtgg     8460

ctacagctga aagatgatga attaagccgg caggcaccta ttggaggcga ctttccagca     8520

gttcagaagc agaacgatgt acatagggcc ttcaagaggg aattgaaaac taaagaacct     8580

gtaatcatga gtactcttga gactgtacga atatttctga cagagcagcc tttggaagga     8640

ctagagaaac tctaccagga gcccagagag ctgcctcctg aggagagagc ccagaatgtc     8700

actcggcttc tacgaaagca ggctgaggag gtcaatactg agtgggaaaa attgaacctg     8760

cactccgctg actggcagag aaaaatagat gagacccttg aaagactcca ggaacttcaa     8820

gaggccacgg atgagctgga cctcaagctg cgccaagctg aggtgatcaa gggatcctgg     8880

cagcccgtgg gcgatctcct cattgactct ctccaagatc acctcgagaa agtcaaggca     8940

cttcgaggag aaattgcgcc tctgaaagag aacgtgagcc acgtcaatga ccttgctcgc     9000

cagcttacca ctttgggcat tcagctctca ccgtataacc tcagcactct ggaagacctg     9060

aacaccagat ggaagcttct gcaggtggcc gtcgaggacc gagtcaggca gctgcatgaa     9120

gcccacaggg actttggtcc agcatctcag cactttcttt ccacgtctgt ccagggtccc     9180

tgggagagag ccatctcgcc aaacaaagtg ccctactata tcaaccacga gactcaaaca     9240

acttgctggg accatcccaa aatgacagag ctctaccagt ctttagctga cctgaataat     9300

gtcagattct cagcttatag gactgccatg aaactccgaa gactgcagaa ggccctttgc     9360

ttggatctct tgagcctgtc agctgcatgt gatgccttgg accagcacaa cctcaagcaa     9420

aatgaccagc ccatggatat cctgcagatt attaattgtt tgaccactat ttatgaccgc     9480

ctggagcaag agcacaacaa tttggtcaac gtccctctct gcgtggatat gtgtctgaac     9540

tggctgctga atgtttatga tacgggacga acagggagga tccgtgtcct gtcttttaaa     9600

actggcatca tttccctgtg taaagcacat ttggaagaca agtacagata ccttttcaag     9660

caagtggcaa gttcaacagg attttgtgac cagcgcaggc tgggcctcct tctgcatgat     9720

tctatccaaa ttccaagaca gttgggtgaa gttgcatcct ttgggggcag taacattgag     9780

ccaagtgtcc ggagctgctt ccaatttgct aataataagc cagagatcga agcggccctc     9840

ttcctagact ggatgagact ggaaccccag tccatggtgt ggctgcccgt cctgcacaga     9900

gtggctgctg cagaaactgc caagcatcag gccaaatgta acatctgcaa agagtgtcca     9960

atcattggat tcaggtacag gagtctaaag cactttaatt atgacatctg ccaaagctgc    10020

tttttttctg gtcgagttgc aaaaggccat aaaatgcact atcccatggt ggaatattgc    10080

actccgacta catcaggaga agatgttcga gactttgcca aggtactaaa aaacaaattt    10140

cgaaccaaaa ggtattttgc gaagcatccc cgaatgggct acctgccagt gcagactgtc    10200

ttagaggggg acaacatgga aactcccgtt actctgatca acttctggcc agtagattct    10260

gcgcctgcct cgtcccctca gctttcacac gatgatactc attcacgcat tgaacattat    10320

gctagcaggc tagcagaaat ggaaaacagc aatggatctt atctaaatga tagcatctct    10380

cctaatgaga gcatagatga tgaacatttg ttaatccagc attactgcca aagtttgaac    10440

caggactccc ccctgagcca gcctcgtagt cctgcccaga tcttgatttc cttagagagt    10500

gaggaaagag gggagctaga gagaatccta gcagatcttg aggaagaaaa caggaatctg    10560

caagcagaat atgaccgtct aaagcagcag cacgaacata aaggcctgtc cccactgccg    10620

tcccctcctg aaatgatgcc cacctctccc cagagtcccc gggatgctga gctcattgct    10680

gaggccaagc tactgcgtca acacaaaggc cgcctggaag ccaggatgca aatcctggaa    10740

gaccacaata aacagctgga gtcacagtta cacaggctaa ggcagctgct ggagcaaccc    10800

caggcagagg ccaaagtgaa tggcacaacg gtgtcctctc cttctacctc tctacagagg    10860

tccgacagca gtcagcctat gctgctccga gtggttggca gtcaaacttc ggactccatg    10920

ggtgaggaag atcttctcag tcctccccag gacacaagca cagggttaga ggaggtgatg    10980

gagcaactca acaactcctt ccctagttca agaggaagaa atacccctgg aaagccaatg    11040

agagaggaca caatg                                                     11055


<210>  2
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Phe Ile Thr Glu Gln Pro Leu Glu Gly Ile Glu Lys 
1               5                   10              


<210>  3
<211>  3685
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 


Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     


Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         


Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             


Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 


Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 


Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     


Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         


Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             


Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 


Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 


Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     


Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         


Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             


Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 


Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 


Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     


Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         


Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             


Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             


Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             


His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             


Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             


Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             


Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             


Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             


Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             


Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             


Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             


Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             


Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             


Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             


Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             


Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             


Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             


Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             


Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             


Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             


Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             


Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             


Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             


Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             


Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             


Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             


Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             


Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             


Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             


Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             


Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             


Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Gln Arg  Leu Gln Glu 
    1460                 1465                 1470             


Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             


Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             


His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             


Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             


Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             


Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             


Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             


Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             


Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             


Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             


Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             


Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             


Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             


Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             


Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             


Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             


Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             


Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             


Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             


Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             


Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             


Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             


Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             


Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             


Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             


Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             


Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             


Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             


Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             


Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             


Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             


Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             


Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             


Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             


Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             


Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             


Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             


Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             


Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             


Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             


Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             


Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             


Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             


Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             


Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             


Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             


Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             


Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             


Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             


Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             


Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             


Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             


Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             


Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             


Gln Glu  Gly Pro Phe Asp Val  Gln Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             


Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             


Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             


Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             


Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             


Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             


Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             


Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             


Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             


Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             


Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             


Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             


Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             


Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             


Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             


Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             


Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             


Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             


Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             


Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             


Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             


His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             


Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             


Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             


Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             


Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             


Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             


Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             


Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             


Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             


Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             


Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             


Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             


Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             


Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             


Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             


Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             


Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             


Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             


Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             


Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             


His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             


Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             


Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             


Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             


Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             


Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             


Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             


Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             


Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             


Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             


His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             


Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             


His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             


Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             


Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             


Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             


Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             


Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             


Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             


Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             


Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             


Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             


Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             


Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             


Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             


Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             


Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210>  4
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys Phe Phe 
1               5                   10                  15      


Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met Val Glu 
            20                  25                  30          


Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys 
        35                  40                  45              


Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro 
    50                  55                  60                  


Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met 
65                  70                  75                  80  


Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro 
                85                  90                  95      


Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu 
            100                 105                 110         


His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr 
        115                 120                 125             


Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu 
    130                 135                 140                 


Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser 
145                 150                 155                 160 


Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu 
                165                 170                 175     


Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg 
            180                 185                 190         


Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys 
        195                 200                 205             


Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro 
    210                 215                 220                 


Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg 
225                 230                 235                 240 


Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His 
                245                 250                 255     


Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu Glu 
            260                 265                 270         


Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro 
        275                 280                 285             


Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg 
    290                 295                 300                 


Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu 
305                 310                 315                 320 


Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln 
                325                 330                 335     


Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys 
            340                 345                 350         


Pro Met Arg Glu Asp Thr Met 
        355                 


<210>  5
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Ser Leu Lys His Phe Asn Tyr Asp Ile Cys Gln Ser Cys Phe Phe 
1               5                   10                  15      


Ser Gly Arg Val Ala Lys Gly His Lys Met His Tyr Pro Met Val Glu 
            20                  25                  30          


Tyr Cys Thr Pro Thr Thr Ser Gly Glu Asp Val Arg Asp Phe Ala Lys 
        35                  40                  45              


Val Leu Lys Asn Lys Phe Arg Thr Lys Arg Tyr Phe Ala Lys His Pro 
    50                  55                  60                  


Arg Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met 
65                  70                  75                  80  


Glu Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro 
                85                  90                  95      


Ala Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg Ile Glu 
            100                 105                 110         


His Tyr Ala Ser Arg Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr 
        115                 120                 125             


Leu Asn Asp Ser Ile Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu 
    130                 135                 140                 


Leu Ile Gln His Tyr Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser 
145                 150                 155                 160 


Gln Pro Arg Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu 
                165                 170                 175     


Arg Gly Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg 
            180                 185                 190         


Asn Leu Gln Ala Glu Tyr Asp Arg Leu Lys Gln Gln His Glu His Lys 
        195                 200                 205             


Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro 
    210                 215                 220                 


Gln Ser Pro Arg Asp Ala Glu Leu Ile Ala Glu Ala Lys Leu Leu Arg 
225                 230                 235                 240 


Gln His Lys Gly Arg Leu Glu Ala Arg Met Gln Ile Leu Glu Asp His 
                245                 250                 255     


Asn Lys Gln Leu Glu Ser Gln Leu His Arg Leu Arg Gln Leu Leu Glu 
            260                 265                 270         


Gln Pro Gln Ala Glu Ala Lys Val Asn Gly Thr Thr Val Ser Ser Pro 
        275                 280                 285             


Ser Thr Ser Leu Gln Arg Ser Asp Ser Ser Gln Pro Met Leu Leu Arg 
    290                 295                 300                 


Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu 
305                 310                 315                 320 


Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln 
                325                 330                 335     


Leu Asn Asn Ser Phe Pro Ser Ser Arg Gly Arg Asn Thr Pro Gly Lys 
            340                 345                 350         


Pro Met Arg Glu Asp Thr Met 
        355                 


<210>  6
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Lys His Asn Gln Gly Lys Glu Ala Ala Gln Arg Val Leu Ser Gln 
1               5                   10                  15      


Ile Asp Val Ala Gln Lys Lys Leu Gln Asp Val Ser Met Lys Phe Arg 
            20                  25                  30          


Leu Phe Gln Lys Pro Ala Asn Phe Glu Gln Arg Leu Gln Glu Ser Lys 
        35                  40                  45              


Met Ile Leu Asp Glu Val Lys Met His Leu Pro Ala Leu Glu Thr Lys 
    50                  55                  60                  


Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu 
65                  70                  75  


<210>  7
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  7

Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln 
1               5                   10                  15      


<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  8

Pro Gly Lys Pro Met Arg Glu Asp Thr Met 
1               5                   10  


<210>  9
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  9
cctggaaagc caatgagaga ggacacaatg                                        30


<210>  10
<211>  1944
<212>  DNA
<213>  Homo sapiens

<400>  10
aagaaacata atcaggggaa ggaggctgcc caaagagtcc tgtctcagat tgatgttgca       60

cagaaaaaat tacaagatgt ctccatgaag tttcgattat tccagaaacc agccaatttt      120

gagcagcgtc tacaagaaag taagatgatt ttagatgaag tgaagatgca cttgcctgca      180

ttggaaacaa agagtgtgga acaggaagta gtacagtcac agctaaatca ttgtgtgaac      240

ttgtataaaa gtctgagtga agtgaagtct gaagtggaaa tggtgataaa gactggacgt      300

cagattgtac agaaaaagca gacggaaaat cccaaagaac ttgatgaaag agtaacagct      360

ttgaaattgc attataatga gctgggagca aaggtaacag aaagaaagca acagttggag      420

aaatgcttga aattgtcccg taagatgcga aaggaaatga atgtcttgac agaatggctg      480

gcagctacag atatggaatt gacaaagaga tcagcagttg aaggaatgcc tagtaatttg      540

gattctgaag ttgcctgggg aaaggctact caaaaagaga ttgagaaaca gaaggtgcac      600

ctgaagagta tcacagaggt aggagaggcc ttgaaaacag ttttgggcaa gaaggagacg      660

ttggtggaag ataaactcag tcttctgaat agtaactgga tagctgtcac ctcccgagca      720

gaagagtggt taaatctttt gttggaatac cagaaacaca tggaaacttt tgaccagaat      780

gtggaccaca tcacaaagtg gatcattcag gctgacacac ttttggatga atcagagaaa      840

aagaaacccc agcaaaaaga agacgtgctt aagcgtttaa aggcagaact gaatgacata      900

cgcccaaagg tggactctac acgtgaccaa gcagcaaact tgatggcaaa ccgcggtgac      960

cactgcagga aattagtaga gccccaaatc tcagagctca accatcgatt tgcagccatt     1020

tcacacagaa ttaagactgg aaaggcctcc attcctttga aggaattgga gcagtttaac     1080

tcagatatac aaaaattgct tgaaccactg gaggctgaaa ttcagcaggg ggtgaatctg     1140

aaagaggaag acttcaataa agatatgaat gaagacaatg agggtactgt aaaagaattg     1200

ttgcaaagag gagacaactt acaacaaaga atcacagatg agagaaagcg agaggaaata     1260

aagataaaac agcagctgtt acagacaaaa cataatgctc tcaaggattt gaggtctcaa     1320

agaagaaaaa aggctctaga aatttctcat cagtggtatc agtacaagag gcaggctgat     1380

gatctcctga aatgcttgga tgacattgaa aaaaaattag ccagcctacc tgagcccaga     1440

gatgaaagga aaataaagga aattgatcgg gaattgcaga agaagaaaga ggagctgaat     1500

gcagtgcgta ggcaagctga gggcttgtct gaggatgggg ccgcaatggc agtggagcca     1560

actcagatcc agctcagcaa gcgctggcgg gaaattgaga gcaaatttgc tcagtttcga     1620

agactcaact ttgcacaaat tcacactgtc cgtgaagaaa cgatgatggt gatgactgaa     1680

gacatgcctt tggaaatttc ttatgtgcct tctacttatt tgactgaaat cactcatgtc     1740

tcacaagccc tattagaagt ggaacaactt ctcaatgctc ctgacctctg tgctaaggac     1800

tttgaagatc tctttaagca agaggagtct ctgaagaata taaaagatag tctacaacaa     1860

agctcaggtc ggattgacat tattcatagc aagaagacag cagcattgca aagtgcaacg     1920

cctgtggaaa gggtgaagct acag                                            1944


<210>  11
<211>  225
<212>  DNA
<213>  Homo sapiens

<400>  11
aagaaacata atcaggggaa ggaggctgcc caaagagtcc tgtctcagat tgatgttgca       60

cagaaaaaat tacaagatgt ctccatgaag tttcgattat tccagaaacc agccaatttt      120

gagcagcgtc tacaagaaag taagatgatt ttagatgaag tgaagatgca cttgcctgca      180

ttggaaacaa agagtgtgga acaggaagta gtacagtcac agcta                      225


<210>  12
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  12
acagcagcat tgcaaagtgc aacgcctgtg gaaagggtga agctacag                    48


