                         SEQUENCE LISTING

<110>  Sanquin Innovatie B.V.
 
<120>  ADAMTS13 protein variants and uses thereof

<130>  P126141PC00

<140>  PCT/NL2021/050325
<141>  2021-05-25

<150>  EP 20176333.1
<151>  2020-05-25

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  1427
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Gln Arg His Pro Arg Ala Arg Cys Pro Pro Leu Cys Val Ala 
1               5                   10                  15      


Gly Ile Leu Ala Cys Gly Phe Leu Leu Gly Cys Trp Gly Pro Ser His 
            20                  25                  30          


Phe Gln Gln Ser Cys Leu Gln Ala Leu Glu Pro Gln Ala Val Ser Ser 
        35                  40                  45              


Tyr Leu Ser Pro Gly Ala Pro Leu Lys Gly Arg Pro Pro Ser Pro Gly 
    50                  55                  60                  


Phe Gln Arg Gln Arg Gln Arg Gln Arg Arg Ala Ala Gly Gly Ile Leu 
65                  70                  75                  80  


His Leu Glu Leu Leu Val Ala Val Gly Pro Asp Val Phe Gln Ala His 
                85                  90                  95      


Gln Glu Asp Thr Glu Arg Tyr Val Leu Thr Asn Leu Asn Ile Gly Ala 
            100                 105                 110         


Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg Val His Leu 
        115                 120                 125             


Val Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr 
    130                 135                 140                 


Ala Asn Leu Thr Ser Ser Leu Leu Ser Val Cys Gly Trp Ser Gln Thr 
145                 150                 155                 160 


Ile Asn Pro Glu Asp Asp Thr Asp Pro Gly His Ala Asp Leu Val Leu 
                165                 170                 175     


Tyr Ile Thr Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln Val 
            180                 185                 190         


Arg Gly Val Thr Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp Ser Cys 
        195                 200                 205             


Leu Ile Thr Glu Asp Thr Gly Phe Asp Leu Gly Val Thr Ile Ala His 
    210                 215                 220                 


Glu Ile Gly His Ser Phe Gly Leu Glu His Asp Gly Ala Pro Gly Ser 
225                 230                 235                 240 


Gly Cys Gly Pro Ser Gly His Val Met Ala Ser Asp Gly Ala Ala Pro 
                245                 250                 255     


Arg Ala Gly Leu Ala Trp Ser Pro Cys Ser Arg Arg Gln Leu Leu Ser 
            260                 265                 270         


Leu Leu Ser Ala Gly Arg Ala Arg Cys Val Trp Asp Pro Pro Arg Pro 
        275                 280                 285             


Gln Pro Gly Ser Ala Gly His Pro Pro Asp Ala Gln Pro Gly Leu Tyr 
    290                 295                 300                 


Tyr Ser Ala Asn Glu Gln Cys Arg Val Ala Phe Gly Pro Lys Ala Val 
305                 310                 315                 320 


Ala Cys Thr Phe Ala Arg Glu His Leu Asp Met Cys Gln Ala Leu Ser 
                325                 330                 335     


Cys His Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu Val 
            340                 345                 350         


Pro Leu Leu Asp Gly Thr Glu Cys Gly Val Glu Lys Trp Cys Ser Lys 
        355                 360                 365             


Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val His 
    370                 375                 380                 


Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser Cys 
385                 390                 395                 400 


Gly Gly Gly Val Val Thr Arg Arg Arg Gln Cys Asn Asn Pro Arg Pro 
                405                 410                 415     


Ala Phe Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu Met 
            420                 425                 430         


Cys Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu Phe Met Ser Gln 
        435                 440                 445             


Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly Gly 
    450                 455                 460                 


Ala Ser Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp 
465                 470                 475                 480 


Ala Leu Cys Arg His Met Cys Arg Ala Ile Gly Glu Ser Phe Ile Met 
                485                 490                 495     


Lys Arg Gly Asp Ser Phe Leu Asp Gly Thr Arg Cys Met Pro Ser Gly 
            500                 505                 510         


Pro Arg Glu Asp Gly Thr Leu Ser Leu Cys Val Ser Gly Ser Cys Arg 
        515                 520                 525             


Thr Phe Gly Cys Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
    530                 535                 540                 


Cys Gln Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly 
545                 550                 555                 560 


Ser Phe Thr Ala Gly Arg Ala Arg Glu Tyr Val Thr Phe Leu Thr Val 
                565                 570                 575     


Thr Pro Asn Leu Thr Ser Val Tyr Ile Ala Asn His Arg Pro Leu Phe 
            580                 585                 590         


Thr His Leu Ala Val Arg Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
        595                 600                 605             


Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
    610                 615                 620                 


Arg Val Glu Tyr Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg Leu 
625                 630                 635                 640 


Glu Glu Ile Arg Ile Trp Gly Pro Leu Gln Glu Asp Ala Asp Ile Gln 
                645                 650                 655     


Val Tyr Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg Pro Asp 
            660                 665                 670         


Ile Thr Phe Thr Tyr Phe Gln Pro Lys Pro Arg Gln Ala Trp Val Trp 
        675                 680                 685             


Ala Ala Val Arg Gly Pro Cys Ser Val Ser Cys Gly Ala Gly Leu Arg 
    690                 695                 700                 


Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys Glu Leu Val Glu 
705                 710                 715                 720 


Thr Val Gln Cys Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala 
                725                 730                 735     


Cys Val Leu Glu Pro Cys Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly 
            740                 745                 750         


Pro Cys Ser Ala Ser Cys Gly Gly Gly Leu Arg Glu Arg Pro Val Arg 
        755                 760                 765             


Cys Val Glu Ala Gln Gly Ser Leu Leu Lys Thr Leu Pro Pro Ala Arg 
    770                 775                 780                 


Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu Glu Thr Cys Asn 
785                 790                 795                 800 


Pro Gln Pro Cys Pro Ala Arg Trp Glu Val Ser Glu Pro Ser Ser Cys 
                805                 810                 815     


Thr Ser Ala Gly Gly Ala Gly Leu Ala Leu Glu Asn Glu Thr Cys Val 
            820                 825                 830         


Pro Gly Ala Asp Gly Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser 
        835                 840                 845             


Val Asp Glu Lys Leu Pro Ala Pro Glu Pro Cys Val Gly Met Ser Cys 
    850                 855                 860                 


Pro Pro Gly Trp Gly His Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala 
865                 870                 875                 880 


Pro Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val 
                885                 890                 895     


Trp Thr Pro Ala Ala Gly Ser Cys Ser Val Ser Cys Gly Arg Gly Leu 
            900                 905                 910         


Met Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val 
        915                 920                 925             


Gln Glu Glu Leu Cys Gly Leu Ala Ser Lys Pro Gly Ser Arg Arg Glu 
    930                 935                 940                 


Val Cys Gln Ala Val Pro Cys Pro Ala Arg Trp Gln Tyr Lys Leu Ala 
945                 950                 955                 960 


Ala Cys Ser Val Ser Cys Gly Arg Gly Val Val Arg Arg Ile Leu Tyr 
                965                 970                 975     


Cys Ala Arg Ala His Gly Glu Asp Asp Gly Glu Glu Ile Leu Leu Asp 
            980                 985                 990         


Thr Gln Cys Gln Gly Leu Pro Arg  Pro Glu Pro Gln Glu  Ala Cys Ser 
        995                 1000                 1005             


Leu Glu  Pro Cys Pro Pro Arg  Trp Lys Val Met Ser  Leu Gly Pro 
    1010                 1015                 1020             


Cys Ser  Ala Ser Cys Gly Leu  Gly Thr Ala Arg Arg  Ser Val Ala 
    1025                 1030                 1035             


Cys Val  Gln Leu Asp Gln Gly  Gln Asp Val Glu Val  Asp Glu Ala 
    1040                 1045                 1050             


Ala Cys  Ala Ala Leu Val Arg  Pro Glu Ala Ser Val  Pro Cys Leu 
    1055                 1060                 1065             


Ile Ala  Asp Cys Thr Tyr Arg  Trp His Val Gly Thr  Trp Met Glu 
    1070                 1075                 1080             


Cys Ser  Val Ser Cys Gly Asp  Gly Ile Gln Arg Arg  Arg Asp Thr 
    1085                 1090                 1095             


Cys Leu  Gly Pro Gln Ala Gln  Ala Pro Val Pro Ala  Asp Phe Cys 
    1100                 1105                 1110             


Gln His  Leu Pro Lys Pro Val  Thr Val Arg Gly Cys  Trp Ala Gly 
    1115                 1120                 1125             


Pro Cys  Val Gly Gln Gly Thr  Pro Ser Leu Val Pro  His Glu Glu 
    1130                 1135                 1140             


Ala Ala  Ala Pro Gly Arg Thr  Thr Ala Thr Pro Ala  Gly Ala Ser 
    1145                 1150                 1155             


Leu Glu  Trp Ser Gln Ala Arg  Gly Leu Leu Phe Ser  Pro Ala Pro 
    1160                 1165                 1170             


Gln Pro  Arg Arg Leu Leu Pro  Gly Pro Gln Glu Asn  Ser Val Gln 
    1175                 1180                 1185             


Ser Ser  Ala Cys Gly Arg Gln  His Leu Glu Pro Thr  Gly Thr Ile 
    1190                 1195                 1200             


Asp Met  Arg Gly Pro Gly Gln  Ala Asp Cys Ala Val  Ala Ile Gly 
    1205                 1210                 1215             


Arg Pro  Leu Gly Glu Val Val  Thr Leu Arg Val Leu  Glu Ser Ser 
    1220                 1225                 1230             


Leu Asn  Cys Ser Ala Gly Asp  Met Leu Leu Leu Trp  Gly Arg Leu 
    1235                 1240                 1245             


Thr Trp  Arg Lys Met Cys Arg  Lys Leu Leu Asp Met  Thr Phe Ser 
    1250                 1255                 1260             


Ser Lys  Thr Asn Thr Leu Val  Val Arg Gln Arg Cys  Gly Arg Pro 
    1265                 1270                 1275             


Gly Gly  Gly Val Leu Leu Arg  Tyr Gly Ser Gln Leu  Ala Pro Glu 
    1280                 1285                 1290             


Thr Phe  Tyr Arg Glu Cys Asp  Met Gln Leu Phe Gly  Pro Trp Gly 
    1295                 1300                 1305             


Glu Ile  Val Ser Pro Ser Leu  Ser Pro Ala Thr Ser  Asn Ala Gly 
    1310                 1315                 1320             


Gly Cys  Arg Leu Phe Ile Asn  Val Ala Pro His Ala  Arg Ile Ala 
    1325                 1330                 1335             


Ile His  Ala Leu Ala Thr Asn  Met Gly Ala Gly Thr  Glu Gly Ala 
    1340                 1345                 1350             


Asn Ala  Ser Tyr Ile Leu Ile  Arg Asp Thr His Ser  Leu Arg Thr 
    1355                 1360                 1365             


Thr Ala  Phe His Gly Gln Gln  Val Leu Tyr Trp Glu  Ser Glu Ser 
    1370                 1375                 1380             


Ser Gln  Ala Glu Met Glu Phe  Ser Glu Gly Phe Leu  Lys Ala Gln 
    1385                 1390                 1395             


Ala Ser  Leu Arg Gly Gln Tyr  Trp Thr Leu Gln Ser  Trp Val Pro 
    1400                 1405                 1410             


Glu Met  Gln Asp Pro Gln Ser  Trp Lys Gly Lys Glu  Gly Thr 
    1415                 1420                 1425         


<210>  2
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  2

Lys Met Ser Ile 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS13 variant NGLY3

<400>  3

Asn Met Ser Ile 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS13 variant NGLY4

<400>  4

Lys Asn Ser Thr 
1               


<210>  5
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Leu Pro Arg 
1               


<210>  6
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS13 variant NGLY5

<400>  6

Asn Leu Ser Arg 
1               


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADAMTS13 variant NGLY6

<400>  7

Arg Asn Ala Ser 
1               


<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Gly Gly Arg Tyr Val Val Ala Gly Lys 
1               5                   10  


<210>  9
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly 
1               5                   10                  15      


Arg Val Glu Tyr Arg 
            20      


<210>  10
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Gly Gly Arg Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn 
1               5                   10                  15      


Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg 
            20                  25                  30      


<210>  11
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide 3 NGLY3

<400>  11

Tyr Val Val Ala Gly Asn Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
1               5                   10                  15      


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg 
            20                  25          


<210>  12
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NGLY3 599-629

<400>  12

Ile Gly Gly Arg Tyr Val Val Ala Gly Asn Met Ser Ile Ser Pro Asn 
1               5                   10                  15      


Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg 
            20                  25                  30      


<210>  13
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K608A peptide 3

<400>  13

Tyr Val Val Ala Gly Ala Met Ser Ile Ser Pro Asn Thr Thr Tyr Pro 
1               5                   10                  15      


Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg 
            20                  25          


<210>  14
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  K608A aa599-629

<400>  14

Ile Gly Gly Arg Tyr Val Val Ala Gly Ala Met Ser Ile Ser Pro Asn 
1               5                   10                  15      


Thr Thr Tyr Pro Ser Leu Leu Glu Asp Gly Arg Val Glu Tyr Arg 
            20                  25                  30      


<210>  15
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Phe Arg Tyr Tyr 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gain of function variant

<400>  16

Lys Tyr Lys Phe Phe 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Arg Glu Tyr Val 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NGLY1

<400>  18

Ala Asn Glu Thr Val 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  19

Pro Leu Phe Thr His 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NGLY2

<400>  20

Pro Asn Phe Thr His 
1               5   


<210>  21
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly Lys Met Ser Ile 
1               5   


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NGLY3

<400>  22

Gly Asn Met Ser Ile 
1               5   


<210>  23
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  23

Lys Met Ser Ile Ser 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NGLY4

<400>  24

Lys Asn Ser Thr Ser 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  25

Asp Arg Leu Pro Arg 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NGLY5

<400>  26

Asp Asn Leu Ser Arg 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  27

Arg Leu Pro Arg Leu 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NGLY6

<400>  28

Arg Asn Ala Ser Leu 
1               5   


<210>  29
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Tyr Gly Asn Leu Thr 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-gly7

(glycan shift from N667 to Y665)

<400>  30

Glu Asn Val Thr Leu Thr 
1               5       


<210>  31
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  31

Asn Leu Thr Arg Pro 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-gly8

Glycan shift from N667 to L668)

<400>  32

Leu Asn Val Thr Ala 
1               5   


<210>  33
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  33

Asp Val Phe Gln Ala His Gln Glu Asp Thr Glu Arg 
1               5                   10          


<210>  34
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  34

Glu Leu Leu Arg Asp Pro Ser Leu Gly Ala Gln Phe Arg 
1               5                   10              


<210>  35
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  35

Lys Met Val Ile Leu Thr Glu Pro Glu Gly Ala Pro Asn Ile Thr Ala 
1               5                   10                  15      


Asn Leu Thr Ser Ser Leu Leu 
            20              


<210>  36
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  36

Gln Thr Ile Asn Pro Glu Asp Asp Thr Asp Pro 
1               5                   10      


<210>  37
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  37

Arg Phe Asp Leu Glu Leu Pro Asp Gly Asn Arg Gln 
1               5                   10          


<210>  38
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  38

Gln Leu Gly Gly Ala Cys Ser Pro Thr Trp 
1               5                   10  


<210>  39
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu His Asp Gly Ala Pro Gly Ser Gly Cys Gly Pro Ser 
1               5                   10              


<210>  40
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  40

Ser Asp Gly Ala Ala Pro Arg Ala Gly Leu 
1               5                   10  


<210>  41
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  41

Pro Cys Ser Arg Arg Gln Leu Leu Ser Leu Leu Ser Ala Gly Arg Ala 
1               5                   10                  15      


Arg Cys Val Trp Asp Pro Pro Arg Pro Gln Pro Gly Ser Ala Gly His 
            20                  25                  30          


Pro Pro Asp Ala Gln 
        35          


<210>  42
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  42

Arg Val Ala Phe Gly Pro Lys Ala Val Ala Cys Thr Phe Ala Arg Glu 
1               5                   10                  15      


His Leu Asp Met Cys Gln 
            20          


<210>  43
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  43

Thr Asp Pro Leu Asp Gln Ser Ser Cys Ser Arg Leu Leu 
1               5                   10              


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Asp Gly Thr Glu Cys Gly Val Glu Lys 
1               5                   


<210>  45
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  45

Lys Gly Arg Cys Arg Ser Leu Val Glu Leu Thr Pro Ile Ala Ala Val 
1               5                   10                  15      


His Gly Arg Trp Ser Ser Trp Gly Pro Arg Ser Pro Cys Ser Arg Ser 
            20                  25                  30          


<210>  46
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  46

Arg Arg Arg Gln 
1               


<210>  47
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Gly Arg Ala Cys Val Gly Ala Asp Leu Gln Ala Glu 
1               5                   10              


<210>  48
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  48

Asn Thr Gln Ala Cys Glu Lys Thr Gln Leu Glu 
1               5                   10      


<210>  49
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Gln Cys Ala Arg Thr Asp Gly Gln Pro Leu Arg Ser Ser Pro Gly 
1               5                   10                  15      


Gly Ala 
        


<210>  50
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  50

Phe Tyr His Trp Gly Ala Ala Val Pro His Ser Gln Gly Asp Ala Leu 
1               5                   10                  15      


Cys Arg 
        


<210>  51
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  51

Arg Ala Ile Gly Glu Ser Phe Ile Met Lys Arg Gly Asp Ser Phe Leu 
1               5                   10                  15      


<210>  52
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  52

Ser Gly Pro Arg Glu 
1               5   


<210>  53
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  53

Ser Gly Ser Cys Arg 
1               5   


<210>  54
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  54

Asp Gly Arg Met Asp Ser Gln Gln Val Trp Asp Arg 
1               5                   10          


<210>  55
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  55

Val Cys Gly Gly Asp Asn Ser Thr Cys Ser Pro Arg Lys Gly Ser Phe 
1               5                   10                  15      


Thr Ala Gly Arg Ala Arg Glu 
            20              


<210>  56
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  56

Thr Phe Leu Thr Val Thr Pro Asn 
1               5               


<210>  57
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  57

Tyr Ile Ala Asn His Arg Pro Leu Phe 
1               5                   


<210>  58
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  58

Gly Gly Arg Tyr Val Val Ala Gly Lys Met Ser Ile Ser Pro Asn 
1               5                   10                  15  


<210>  59
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  59

Tyr Pro Ser Leu Leu Glu Asp 
1               5           


<210>  60
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  60

Arg Val Ala Leu Thr Glu Asp Arg Leu Pro Arg 
1               5                   10      


<210>  61
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  61

Arg Ile Trp Gly Pro Leu Gln Glu Asp 
1               5                   


<210>  62
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  62

Arg Arg Tyr Gly Glu Glu Tyr Gly Asn Leu Thr Arg 
1               5                   10          


<210>  63
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  63

Thr Phe Thr Tyr Phe Gln Pro Lys 
1               5               


<210>  64
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  64

Pro Arg Gln Ala Trp Val Trp Ala Ala Val Arg Gly Pro Cys Ser 
1               5                   10                  15  


<210>  65
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  65

Ala Gly Leu Arg Trp Val Asn Tyr Ser Cys Leu Asp Gln Ala Arg Lys 
1               5                   10                  15      


Glu Leu Val Glu 
            20  


<210>  66
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  66

Gln Gly Ser Gln Gln Pro Pro Ala Trp Pro Glu Ala Cys Val Leu Glu 
1               5                   10                  15      


Pro 
    


<210>  67
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  67

Pro Pro Tyr Trp Ala Val Gly Asp Phe Gly Pro Cys Ser Ala Ser Cys 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  68

Leu Arg Glu Arg Pro Val Arg Cys Val Glu Ala Gln Gly Ser Leu Leu 
1               5                   10                  15      


<210>  69
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  69

Pro Pro Ala Arg Cys Arg Ala Gly Ala Gln Gln Pro Ala Val Ala Leu 
1               5                   10                  15      


Glu Thr Cys Asn Pro Gln Pro Cys Pro Ala Arg 
            20                  25          


<210>  70
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  70

Trp Glu Val Ser Glu Pro Ser Ser Cys Thr Ser Ala Gly Gly Ala Gly 
1               5                   10                  15      


Leu 
    


<210>  71
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  71

Asn Glu Thr Cys Val Pro 
1               5       


<210>  72
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  72

Leu Glu Ala Pro Val Thr Glu Gly Pro Gly Ser Val Asp Glu Lys 
1               5                   10                  15  


<210>  73
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  73

Ala Pro Glu Pro Cys Val Gly Met Ser Cys Pro Pro Gly 
1               5                   10              


<210>  74
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  74

Leu Asp Ala Thr Ser Ala Gly Glu Lys Ala Pro 
1               5                   10      


<210>  75
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  75

Ser Pro Trp Gly Ser Ile Arg Thr Gly Ala Gln Ala Ala His Val Trp 
1               5                   10                  15      


<210>  76
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  76

Val Ser Cys Gly Arg 
1               5   


<210>  77
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  77

Glu Leu Arg Phe Leu Cys Met Asp Ser Ala Leu Arg Val Pro Val Gln 
1               5                   10                  15      


Glu Glu Leu Cys Gly Leu 
            20          


<210>  78
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  78

Lys Pro Gly Ser Arg Arg Glu Cys Pro Ala Arg Trp Gln Tyr Lys Leu 
1               5                   10                  15      


Ala Ala Cys Ser Val Ser Cys Gly Arg 
            20                  25  


<210>  79
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  79

Arg Arg Ile Leu Tyr Cys Ala Arg Ala His Gly Glu Asp 
1               5                   10              


<210>  80
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  80

Glu Glu Ile Leu Leu Asp Thr Gln Cys Gln Gly Leu Pro Arg Pro Glu 
1               5                   10                  15      


Pro Gln Glu Ala Cys Ser Leu Glu Pro 
            20                  25  


<210>  81
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  81

Cys Pro Pro Arg Trp 
1               5   


<210>  82
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  82

Pro Cys Ser Ala Ser Cys Gly Leu Gly Thr Ala Arg 
1               5                   10          


<210>  83
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  83

Val Gln Leu Asp Gln Gly Gln Asp Val Glu Val Asp Glu Ala Ala 
1               5                   10                  15  


<210>  84
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  84

Leu Val Arg Pro Glu Ala Ser Val Pro Cys Leu Ile Ala Asp 
1               5                   10                  


<210>  85
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  85

Arg Trp His Val Gly Thr Trp Met Glu Cys Ser Val Ser Cys Gly Asp 
1               5                   10                  15      


<210>  86
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  86

Ala Gln Ala Pro Val Pro Ala Asp Phe Cys Gln His Leu Pro 
1               5                   10                  


<210>  87
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  87

Arg Gly Cys Trp Ala Gly Pro Cys Val Gly Gln Gly Thr Pro Ser Leu 
1               5                   10                  15      


Val Pro His Glu Glu Ala Ala Ala Pro Gly Arg 
            20                  25          


<210>  88
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  88

Pro Ala Gly Ala Ser Leu Glu Trp 
1               5               


<210>  89
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  89

Arg Gly Leu Leu Phe Ser Pro Ala Pro Gln Pro Arg Arg Leu Leu Pro 
1               5                   10                  15      


Gly Pro Gln Glu Asn Ser 
            20          


<210>  90
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  90

Cys Gly Arg Gln His Leu Glu Pro Thr Gly Thr 
1               5                   10      


<210>  91
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  91

Asp Met Arg Gly Pro Gly Gln Ala Asp 
1               5                   


<210>  92
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  92

Gly Arg Pro Leu Gly Glu 
1               5       


<210>  93
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  93

Pro Gly Gln Ala Asp 
1               5   


<210>  94
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  94

Ser Ser Leu Asn Cys Ser Ala Gly Asp Met Leu Leu Leu Trp Gly Arg 
1               5                   10                  15      


Leu 
    


<210>  95
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  95

Asn Cys Ser Ala Gly Asp Met Leu Leu 
1               5                   


<210>  96
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  96

Trp Gly Arg Leu Thr Trp Arg Lys Met Cys Arg Lys Leu Leu Asp Met 
1               5                   10                  15      


<210>  97
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  97

Trp Arg Lys Met Cys Arg Lys Leu Leu Asp Met 
1               5                   10      


<210>  98
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  98

Thr Phe Ser Ser Lys Thr Asn Thr 
1               5               


<210>  99
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  99

Lys Thr Asn Thr 
1               


<210>  100
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  100

Arg Gln Arg Ser Gly Arg Pro Gly Gly Gly Val 
1               5                   10      


<210>  101
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  101

Arg Cys Gly Arg Pro Gly 
1               5       


<210>  102
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  102

Arg Tyr Gly Ser Gln Leu Ala Pro Glu Thr Phe Tyr Arg Glu 
1               5                   10                  


<210>  103
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  103

Gln Leu Ala Pro Glu Thr Phe Tyr Arg Glu 
1               5                   10  


<210>  104
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  104

Asp Met Gln Leu Phe Gly Pro Trp Gly 
1               5                   


<210>  105
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  105

Asp Met Gln Leu Phe Gly Pro Trp Gly Glu Ile Val Ser Pro Ser Leu 
1               5                   10                  15      


Ser Pro Ala Thr Ser Asn Ala 
            20              


<210>  106
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  106

Ser Pro Ser Leu Ser Pro Ala Thr Ser Asn Ala Gly Gly 
1               5                   10              


<210>  107
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  107

Arg Leu Phe Ile Asn Val Ala Pro His Ala Arg Ile 
1               5                   10          


<210>  108
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  108

Ala Pro His Ala Arg 
1               5   


<210>  109
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  109

Thr Asn Met Gly Ala Gly Thr Glu Gly Ala Asn Ala Ser Tyr Ile Leu 
1               5                   10                  15      


<210>  110
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  110

Ala Gly Thr Glu Gly Ala Asn 
1               5           


<210>  111
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  111

Ile Arg Asp Thr His Ser Leu Arg Thr 
1               5                   


<210>  112
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  112

Arg Asp Thr His Ser Leu Arg Thr Thr Ala Phe 
1               5                   10      


<210>  113
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  113

Gln Gln Val Leu Tyr Trp Glu Ser Glu Ser Ser Gln 
1               5                   10          


<210>  114
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  114

Trp Glu Ser Glu Ser Ser Gln Ala Glu 
1               5                   


<210>  115
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  115

Glu Phe Ser Glu Gly Phe Leu Lys Ala Gln Ala Ser 
1               5                   10          


<210>  116
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  116

Ser Glu Gly Phe Leu Lys Ala Gln Ala Ser Leu Arg Gly Gln Tyr 
1               5                   10                  15  


<210>  117
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  117

Leu Gln Ser Trp Val Pro Glu Met Gln Asp Pro Gln Ser Trp Lys Gly 
1               5                   10                  15      


Lys Glu Gly Thr 
            20  


<210>  118
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  118

Arg Leu Pro Leu 
1               


<210>  119
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  119

Tyr Gly Asn Leu 
1               


<210>  120
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NGLY7

<400>  120

Asn Val Thr Leu 
1               


<210>  121
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  121

Asn Leu Thr Arg Pro 
1               5   


<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NGLY8

<400>  122

Leu Asn Val Thr Ala 
1               5   


