                         SEQUENCE LISTING

<110>  COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES 
       ALTERNATIVES
 
<120>  COMPLEXE IMMUNOMODULATEUR ET SES APPLICATIONS POUR LA THRAPIE

<130>  BFF190352

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (BB fragment of Staphylococcus aureus 
       protein A)

<400>  1

Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
            20                  25                  30          


Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn 
    50                  55                  60                  


Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro 
                85                  90                  95      


Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  2
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (ZZ derivative of BB fragment of 
       Staphylococcus aureus protein A)

<400>  2

Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Val Asp Asn Lys Phe Asn 
    50                  55                  60                  


Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Asn Glu Glu Gln Arg Asn Ala Phe Ile Gln Ser Leu Lys Asp Asp Pro 
                85                  90                  95      


Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  3
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (HIV Tat 49-57)

<400>  3

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (HIV Tat 28-48)

<400>  4

Phe Thr Lys Lys Gly Leu Gly Ile Ser Tyr Gly 
1               5                   10      


<210>  5
<211>  154
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (R domain of Diphteria Toxin)

<400>  5

Pro Gly His Lys Thr Gln Pro Phe Leu His Asp Gly Tyr Ala Val Ser 
1               5                   10                  15      


Trp Asn Thr Val Glu Asp Ser Ile Ile Arg Thr Gly Phe Gln Gly Glu 
            20                  25                  30          


Ser Gly His Asp Ile Lys Ile Thr Ala Glu Asn Thr Pro Leu Pro Ile 
        35                  40                  45              


Ala Gly Val Leu Leu Pro Thr Ile Pro Gly Lys Leu Asp Val Asn Lys 
    50                  55                  60                  


Ser Lys Thr His Ile Ser Val Asn Gly Arg Lys Ile Arg Met Arg Cys 
65                  70                  75                  80  


Arg Ala Ile Asp Gly Asp Val Thr Phe Cys Arg Pro Lys Ser Pro Val 
                85                  90                  95      


Tyr Val Gly Asn Gly Val His Ala Asn Leu His Val Ala Phe His Arg 
            100                 105                 110         


Ser Ser Ser Glu Lys Ile His Ser Asn Glu Ile Ser Ser Asp Ser Ile 
        115                 120                 125             


Gly Val Leu Gly Tyr Gln Lys Thr Val Asp His Thr Lys Val Asn Ser 
    130                 135                 140                 


Lys Leu Ser Leu Phe Phe Glu Ile Lys Ser 
145                 150                 


<210>  6
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (penetratin 43-58)

<400>  6

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  7
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (Diphteria Toxin 453-467)

<400>  7

Asn Gly Arg Lys Ile Arg Met Arg Cys Arg Ala Ile Asp Gly Asp 
1               5                   10                  15  


<210>  8
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic ppetide (HIV Tat 37-57)

<400>  8

Cys Phe Thr Lys Lys Gly Leu Gly Ile Ser Tyr Gly Arg Lys Lys Arg 
1               5                   10                  15      


Arg Gln Arg Arg Arg 
            20      


<210>  9
<211>  36
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (HIV Tat22-57C

(22-37)S)

<400>  9

Ser Asn Asn Ser Tyr Ser Lys Lys Ser Ser Phe His Ser Gln Val Ser 
1               5                   10                  15      


Phe Thr Lys Lys Gly Leu Gly Ile Ser Tyr Gly Arg Lys Lys Arg Arg 
            20                  25                  30          


Gln Arg Arg Arg 
        35      


<210>  10
<211>  101
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (HIV Tat consensus sequence)

<400>  10

Met Glu Pro Val Asp Pro Lys Leu Glu Pro Trp Lys His Pro Gly Ser 
1               5                   10                  15      


Gln Pro Lys Thr Ala Cys Asn Asn Cys Tyr Cys Lys Lys Cys Cys Phe 
            20                  25                  30          


His Cys Gln Val Cys Phe Thr Lys Lys Gly Leu Gly Ile Ser Tyr Gly 
        35                  40                  45              


Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala Pro Gln Asp Ser Gln Thr 
    50                  55                  60                  


His Gln Val Ser Leu Ser Lys Gln Pro Ala Ser Gln Pro Arg Gly Asp 
65                  70                  75                  80  


Pro Thr Gly Pro Lys Glu Ser Lys Lys Lys Val Glu Arg Glu Thr Glu 
                85                  90                  95      


Thr Asp Pro Val Asp 
            100     


<210>  11
<211>  873
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (ZZ-DTRBDcoli)

<400>  11
atggcgcaac acgatgaagc cgtagacaac aaattcaaca aagaacaaca aaacgcgttc       60

tatgagatct tacatttacc taacttaaac gaagaacaac gaaacgcctt catccaaagt      120

ttaaaagatg acccaagcca aagcgctaac cttttagcag aagctaaaaa gctaaatgat      180

gctcaggcgc cgaaagtaga caacaaattc aacaaagaac aacaaaacgc gttctatgag      240

atcttacatt tacctaactt aaacgaagaa caacgaaacg ccttcatcca aagtttaaaa      300

gatgacccaa gccaaagcgc taacctttta gcagaagcta aaaagctaaa tgatgctcag      360

gcgccgaaag tagacgcgaa ttcgagctcg gtaccgtcga cgccgggtca taaaacccag      420

ccgtttctgc atgatggcta tgcggtgagc tggaacaccg tggaagatag cattattcgt      480

accggctttc agggcgaaag cggccatgat attaaaatta ccgcggaaaa caccccgctg      540

ccgattgcgg gtgttctgct gccgaccatt ccgggcaaac tggatgtgaa caaaagcaaa      600

acccatatta gcgtgaacgg ccgtaaaatt cgtatgcgtt gccgtgcgat tgatggtgat      660

gtgacctttt gccgtccgaa aagcccggtg tatgtgggca acggcgtgca tgcgaacctg      720

catgtggcgt ttcatcgtag cagcagcgaa aaaatccata gcaacgaaat tagcagcgat      780

agcattggcg tgctgggcta tcagaaaacc gtggatcata ccaaagtgaa ctctaaactg      840

agcctgttct tcgaaatcaa aagcggaagc tta                                   873


<210>  12
<211>  291
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (ZZ-DTRBDcoli)

<400>  12

Met Ala Gln His Asp Glu Ala Val Asp Asn Lys Phe Asn Lys Glu Gln 
1               5                   10                  15      


Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu 
            20                  25                  30          


Gln Arg Asn Ala Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser 
        35                  40                  45              


Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro 
    50                  55                  60                  


Lys Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu 
65                  70                  75                  80  


Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile 
                85                  90                  95      


Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
            100                 105                 110         


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Val Asp Ala Asn Ser 
        115                 120                 125             


Ser Ser Val Pro Ser Thr Pro Gly His Lys Thr Gln Pro Phe Leu His 
    130                 135                 140                 


Asp Gly Tyr Ala Val Ser Trp Asn Thr Val Glu Asp Ser Ile Ile Arg 
145                 150                 155                 160 


Thr Gly Phe Gln Gly Glu Ser Gly His Asp Ile Lys Ile Thr Ala Glu 
                165                 170                 175     


Asn Thr Pro Leu Pro Ile Ala Gly Val Leu Leu Pro Thr Ile Pro Gly 
            180                 185                 190         


Lys Leu Asp Val Asn Lys Ser Lys Thr His Ile Ser Val Asn Gly Arg 
        195                 200                 205             


Lys Ile Arg Met Arg Cys Arg Ala Ile Asp Gly Asp Val Thr Phe Cys 
    210                 215                 220                 


Arg Pro Lys Ser Pro Val Tyr Val Gly Asn Gly Val His Ala Asn Leu 
225                 230                 235                 240 


His Val Ala Phe His Arg Ser Ser Ser Glu Lys Ile His Ser Asn Glu 
                245                 250                 255     


Ile Ser Ser Asp Ser Ile Gly Val Leu Gly Tyr Gln Lys Thr Val Asp 
            260                 265                 270         


His Thr Lys Val Asn Ser Lys Leu Ser Leu Phe Phe Glu Ile Lys Ser 
        275                 280                 285             


Gly Ser Leu 
    290     


<210>  13
<211>  930
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (ZZ-DTRBDHEK )

<400>  13
atgggctggt cctgcatcat cctgtttctg gtggccacag ccaccggtgt tcactctgcc       60

cagcatgatg aggccgtgga caacaagttc aacaaagagc agcagaacgc cttctacgag      120

atcctgcatc tgcccaacct gaacgaggaa cagagaaacg ccttcatcca gagcctgaag      180

gacgacccta gccagagcgc taatctgctg gccgaggcca agaagctgaa cgacgctcag      240

gcccctaaag tcgataacaa gtttaacaaa gaacaacaaa atgcctttta tgagatcctc      300

caccttccga atctcaatga ggaacagcgg aatgccttta ttcagtccct gaaggatgat      360

ccctctcagt ccgccaacct gctggctgaa gctaaaaaac tgaatgatgc ccaggctcct      420

aaggtggacg cgaatgctag cagcggggta ccctcaacac cagggcacaa gactcagccc      480

ttcctgcacg atggctatgc tgtgagctgg aatacagtgg aagattccat cattaggaca      540

ggctttcaag gcgaaagtgg ccatgacatc aagattactg ccgaaaacac cccattgccg      600

atagctggtg ttctccttcc cacgattcct gggaaactgg acgtcaacaa gtccaagact      660

cacatctccg tgaatggacg caaaatacgg atgcgatgta gagccattga tggcgatgtg      720

accttttgca gacccaaatc tcctgtgtac gttgggaatg taggtcatgc gaatctccat      780

gtcgcatttc accgttcatc ctctgagaag atccacagca acgagatcag ctctgactca      840

attggagtgc tgggatacca gaaaaccgta gaccatacca aggtcaacag caagctgagt      900

ctgttcttcg agatcaaaag cggaagctta                                       930


<210>  14
<211>  291
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (ZZ-DTRBDHEK)

<400>  14

Ala Gln His Asp Glu Ala Val Asp Asn Lys Phe Asn Lys Glu Gln Gln 
1               5                   10                  15      


Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln 
            20                  25                  30          


Arg Asn Ala Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala 
        35                  40                  45              


Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55                  60                  


Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile 
65                  70                  75                  80  


Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile Gln 
                85                  90                  95      


Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
            100                 105                 110         


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Val Asp Ala Asn Ala Ser 
        115                 120                 125             


Ser Gly Val Pro Ser Thr Pro Gly His Lys Thr Gln Pro Phe Leu His 
    130                 135                 140                 


Asp Gly Tyr Ala Val Ser Trp Asn Thr Val Glu Asp Ser Ile Ile Arg 
145                 150                 155                 160 


Thr Gly Phe Gln Gly Glu Ser Gly His Asp Ile Lys Ile Thr Ala Glu 
                165                 170                 175     


Asn Thr Pro Leu Pro Ile Ala Gly Val Leu Leu Pro Thr Ile Pro Gly 
            180                 185                 190         


Lys Leu Asp Val Asn Lys Ser Lys Thr His Ile Ser Val Asn Gly Arg 
        195                 200                 205             


Lys Ile Arg Met Arg Cys Arg Ala Ile Asp Gly Asp Val Thr Phe Cys 
    210                 215                 220                 


Arg Pro Lys Ser Pro Val Tyr Val Gly Asn Val Gly His Ala Asn Leu 
225                 230                 235                 240 


His Val Ala Phe His Arg Ser Ser Ser Glu Lys Ile His Ser Asn Glu 
                245                 250                 255     


Ile Ser Ser Asp Ser Ile Gly Val Leu Gly Tyr Gln Lys Thr Val Asp 
            260                 265                 270         


His Thr Lys Val Asn Ser Lys Leu Ser Leu Phe Phe Glu Ile Lys Ser 
        275                 280                 285             


Gly Ser Leu 
    290     


<210>  15
<211>  873
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (BB-DTRBDcoli)

<400>  15
atggcgcaac acgatgaagc cgcagacaac aaattcaaca aagaacaaca aaacgcgttc       60

tatgagatct tacatttacc taacttaaac gaagaacaac gaaacggttt catccaaagt      120

ttaaaagatg acccaagcca aagcgctaac cttttagcag aagctaaaaa gctaaatgat      180

gctcaggcgc cgaaagcaga caacaaattc aacaaagaac aacaaaacgc gttctatgag      240

atcttacatt tacctaactt aaacgaagaa caacgaaacg gtttcatcca aagtttaaaa      300

gatgacccaa gccaaagcgc taacctttta gcagaagcta aaaagctaaa tgatgctcag      360

gcgccgaaag tagacgcgaa ttcgagctcg gtaccgtcga cgccgggtca taaaacccag      420

ccgtttctgc atgatggcta tgcggtgagc tggaacaccg tggaagatag cattattcgt      480

accggctttc agggcgaaag cggccatgat attaaaatta ccgcggaaaa caccccgctg      540

ccgattgcgg gtgttctgct gccgaccatt ccgggcaaac tggatgtgaa caaaagcaaa      600

acccatatta gcgtgaacgg ccgtaaaatt cgtatgcgtt gccgtgcgat tgatggtgat      660

gtgacctttt gccgtccgaa aagcccggtg tatgtgggca acggcgtgca tgcgaacctg      720

catgtggcgt ttcatcgtag cagcagcgaa aaaatccata gcaacgaaat tagcagcgat      780

agcattggcg tgctgggcta tcagaaaacc gtggatcata ccaaagtgaa ctctaaactg      840

agcctgttct tcgaaatcaa aagcggaagc tta                                   873


<210>  16
<211>  291
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (BB-DTRBDcoli)

<400>  16

Met Ala Gln His Asp Glu Ala Ala Asp Asn Lys Phe Asn Lys Glu Gln 
1               5                   10                  15      


Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu 
            20                  25                  30          


Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser 
        35                  40                  45              


Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro 
    50                  55                  60                  


Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu 
65                  70                  75                  80  


Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile 
                85                  90                  95      


Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
            100                 105                 110         


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Val Asp Ala Asn Ser 
        115                 120                 125             


Ser Ser Val Pro Ser Thr Pro Gly His Lys Thr Gln Pro Phe Leu His 
    130                 135                 140                 


Asp Gly Tyr Ala Val Ser Trp Asn Thr Val Glu Asp Ser Ile Ile Arg 
145                 150                 155                 160 


Thr Gly Phe Gln Gly Glu Ser Gly His Asp Ile Lys Ile Thr Ala Glu 
                165                 170                 175     


Asn Thr Pro Leu Pro Ile Ala Gly Val Leu Leu Pro Thr Ile Pro Gly 
            180                 185                 190         


Lys Leu Asp Val Asn Lys Ser Lys Thr His Ile Ser Val Asn Gly Arg 
        195                 200                 205             


Lys Ile Arg Met Arg Cys Arg Ala Ile Asp Gly Asp Val Thr Phe Cys 
    210                 215                 220                 


Arg Pro Lys Ser Pro Val Tyr Val Gly Asn Gly Val His Ala Asn Leu 
225                 230                 235                 240 


His Val Ala Phe His Arg Ser Ser Ser Glu Lys Ile His Ser Asn Glu 
                245                 250                 255     


Ile Ser Ser Asp Ser Ile Gly Val Leu Gly Tyr Gln Lys Thr Val Asp 
            260                 265                 270         


His Thr Lys Val Asn Ser Lys Leu Ser Leu Phe Phe Glu Ile Lys Ser 
        275                 280                 285             


Gly Ser Leu 
    290     


<210>  17
<211>  930
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (BB-DTRBDHEK)

<400>  17
atgggctggt cctgcatcat cctgtttctg gtggccacag ccaccggtgt tcactctgcc       60

cagcatgatg aggccgccga caacaagttc aacaaagagc agcagaacgc cttctacgag      120

atcctgcatc tgcccaacct gaacgaggaa cagagaaacg gcttcatcca gagcctgaag      180

gacgacccta gccagagcgc taatctgctg gccgaggcca agaagctgaa cgacgctcag      240

gcccctaaag ccgataacaa gtttaacaaa gaacaacaaa atgcctttta tgagatcctc      300

caccttccga atctcaatga ggaacagcgg aatggcttta ttcagtccct gaaggatgat      360

ccctctcagt ccgccaacct gctggctgaa gctaaaaaac tgaatgatgc ccaggctcct      420

aaggtggacg cgaatgctag cagcggggta ccctcaacac cagggcacaa gactcagccc      480

ttcctgcacg atggctatgc tgtgagctgg aatacagtgg aagattccat cattaggaca      540

ggctttcaag gcgaaagtgg ccatgacatc aagattactg ccgaaaacac cccattgccg      600

atagctggtg ttctccttcc cacgattcct gggaaactgg acgtcaacaa gtccaagact      660

cacatctccg tgaatggacg caaaatacgg atgcgatgta gagccattga tggcgatgtg      720

accttttgca gacccaaatc tcctgtgtac gttgggaatg taggtcatgc gaatctccat      780

gtcgcatttc accgttcatc ctctgagaag atccacagca acgagatcag ctctgactca      840

attggagtgc tgggatacca gaaaaccgta gaccatacca aggtcaacag caagctgagt      900

ctgttcttcg agatcaaaag cggaagctta                                       930


<210>  18
<211>  291
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (BB-DTRBDHEK)

<400>  18

Ala Gln His Asp Glu Ala Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln 
1               5                   10                  15      


Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln 
            20                  25                  30          


Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala 
        35                  40                  45              


Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55                  60                  


Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile 
65                  70                  75                  80  


Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
                85                  90                  95      


Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
            100                 105                 110         


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Val Asp Ala Asn Ala Ser 
        115                 120                 125             


Ser Gly Val Pro Ser Thr Pro Gly His Lys Thr Gln Pro Phe Leu His 
    130                 135                 140                 


Asp Gly Tyr Ala Val Ser Trp Asn Thr Val Glu Asp Ser Ile Ile Arg 
145                 150                 155                 160 


Thr Gly Phe Gln Gly Glu Ser Gly His Asp Ile Lys Ile Thr Ala Glu 
                165                 170                 175     


Asn Thr Pro Leu Pro Ile Ala Gly Val Leu Leu Pro Thr Ile Pro Gly 
            180                 185                 190         


Lys Leu Asp Val Asn Lys Ser Lys Thr His Ile Ser Val Asn Gly Arg 
        195                 200                 205             


Lys Ile Arg Met Arg Cys Arg Ala Ile Asp Gly Asp Val Thr Phe Cys 
    210                 215                 220                 


Arg Pro Lys Ser Pro Val Tyr Val Gly Asn Val Gly His Ala Asn Leu 
225                 230                 235                 240 


His Val Ala Phe His Arg Ser Ser Ser Glu Lys Ile His Ser Asn Glu 
                245                 250                 255     


Ile Ser Ser Asp Ser Ile Gly Val Leu Gly Tyr Gln Lys Thr Val Asp 
            260                 265                 270         


His Thr Lys Val Asn Ser Lys Leu Ser Leu Phe Phe Glu Ile Lys Ser 
        275                 280                 285             


Gly Ser Leu 
    290     


<210>  19
<211>  504
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic polynucleotide (ZZ-Tat22-57C(22-37)Scoli )

<400>  19
atggcgcaac acgatgaagc cgtagacaac aaattcaaca aagaacaaca aaacgcgttc       60

tatgagatct tacatttacc taacttaaac gaagaacaac gaaacgcctt catccaaagt      120

ttaaaagatg acccaagcca aagcgctaac cttttagcag aagctaaaaa gctaaatgat      180

gctcaggcgc cgaaagtaga caacaaattc aacaaagaac aacaaaacgc gttctatgag      240

atcttacatt tacctaactt aaacgaagaa caacgaaacg ccttcatcca aagtttaaaa      300

gatgacccaa gccaaagcgc taacctttta gcagaagcta aaaagctaaa tgatgctcag      360

gcgccgaaag tagacgcgaa ttcgagctcg gtacccagca ataattccta tagcaaaaaa      420

agcagctttc atagccaggt gagctttacc aaaaaaggcc tgggcattag ctatggccgt      480

aaaaaacgtc gtcagcgtcg tcgt                                             504


<210>  20
<211>  168
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic polypeptide (ZZ-Tat22-57C(22-37)Scoli )

<400>  20

Met Ala Gln His Asp Glu Ala Val Asp Asn Lys Phe Asn Lys Glu Gln 
1               5                   10                  15      


Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu 
            20                  25                  30          


Gln Arg Asn Ala Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser 
        35                  40                  45              


Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro 
    50                  55                  60                  


Lys Val Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu 
65                  70                  75                  80  


Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Ala Phe Ile 
                85                  90                  95      


Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu 
            100                 105                 110         


Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Val Asp Ala Asn Ser 
        115                 120                 125             


Ser Ser Val Pro Ser Asn Asn Ser Tyr Ser Lys Lys Ser Ser Phe His 
    130                 135                 140                 


Ser Gln Val Ser Phe Thr Lys Lys Gly Leu Gly Ile Ser Tyr Gly Arg 
145                 150                 155                 160 


Lys Lys Arg Arg Gln Arg Arg Arg 
                165             


<210>  21
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (linker)

<400>  21

Val Asp Ala Asn Ser Ser Ser Val Pro Ser Thr 
1               5                   10      


<210>  22
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (linker)

<400>  22

Val Asp Ala Asn Ala Ser Ser Gly Val Pro Ser Thr 
1               5                   10          


<210>  23
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide (linker)

<400>  23

Val Asp Ala Asn Ser Ser Ser Val Pro 
1               5                   


