                         SEQUENCE LISTING

<110>  GENEURO SA
       FONDAMENTAL
 
<120>  Anti-HERV-W envelope protein antibody for use in the treatment of
        psychotic diseases

<130>  B1905917EPWO

<150>  EP20305561.1
<151>  2020-05-28

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-VL1

<400>  1

Lys Ser Leu Leu His Ser Lys Gly Ile Thr Tyr 
1               5                   10      


<210>  2
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-VL2

<400>  2

Gln Met Ser 
1           


<210>  3
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-VL3

<400>  3

Ala Gln Asn Leu Glu Leu Pro Trp Thr 
1               5                   


<210>  4
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-VH1

<400>  4

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  5
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-VH2

<400>  5

Ile Tyr Pro Gly Lys Ser Asp Thr Ser 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDR-VH3

<400>  6

Thr Arg Thr Val Tyr Ala Met Asp Tyr 
1               5                   


<210>  7
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL

<400>  7

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Lys Gly Ile Thr Tyr Leu Tyr Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser His Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  8
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH

<400>  8

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Lys Ser Asp Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Thr Val Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  9
<211>  542
<212>  PRT
<213>  protein ENV of the Human endogenous retrovirus-W

<400>  9

Met Ala Leu Pro Tyr His Thr Phe Leu Phe Thr Val Leu Leu Pro Pro 
1               5                   10                  15      


Phe Ala Leu Thr Ala Pro Pro Pro Cys Cys Cys Thr Thr Ser Ser Ser 
            20                  25                  30          


Pro Tyr Gln Glu Phe Leu Trp Arg Thr Arg Leu Pro Gly Asn Ile Asp 
        35                  40                  45              


Ala Pro Ser Tyr Arg Ser Leu Ser Lys Gly Asn Ser Thr Phe Thr Ala 
    50                  55                  60                  


His Thr His Met Pro Arg Asn Cys Tyr Asn Ser Ala Thr Leu Cys Met 
65                  70                  75                  80  


His Ala Asn Thr His Tyr Trp Thr Gly Lys Met Ile Asn Pro Ser Cys 
                85                  90                  95      


Pro Gly Gly Leu Gly Ala Thr Val Cys Trp Thr Tyr Phe Thr His Thr 
            100                 105                 110         


Ser Met Ser Asp Gly Gly Gly Ile Gln Gly Gln Ala Arg Glu Lys Gln 
        115                 120                 125             


Val Lys Glu Ala Ile Ser Gln Leu Thr Arg Gly His Ser Thr Pro Ser 
    130                 135                 140                 


Pro Tyr Lys Gly Leu Val Leu Ser Lys Leu His Glu Thr Leu Arg Thr 
145                 150                 155                 160 


His Thr Arg Leu Val Ser Leu Phe Asn Thr Thr Leu Thr Arg Leu His 
                165                 170                 175     


Glu Val Ser Ala Gln Asn Pro Thr Asn Cys Trp Met Cys Leu Pro Leu 
            180                 185                 190         


His Phe Arg Pro Tyr Ile Ser Ile Pro Val Pro Glu Gln Trp Asn Asn 
        195                 200                 205             


Phe Ser Thr Glu Ile Asn Thr Thr Ser Val Leu Val Gly Pro Leu Val 
    210                 215                 220                 


Ser Asn Leu Glu Ile Thr His Thr Ser Asn Leu Thr Cys Val Lys Phe 
225                 230                 235                 240 


Ser Asn Thr Ile Asp Thr Thr Ser Ser Gln Cys Ile Arg Trp Val Thr 
                245                 250                 255     


Pro Pro Thr Arg Ile Val Cys Leu Pro Ser Gly Ile Phe Phe Val Cys 
            260                 265                 270         


Gly Thr Ser Ala Tyr His Cys Leu Asn Gly Ser Ser Glu Ser Met Cys 
        275                 280                 285             


Phe Leu Ser Phe Leu Val Pro Pro Met Thr Ile Tyr Thr Glu Gln Asp 
    290                 295                 300                 


Leu Tyr Asn His Val Val Pro Lys Pro His Asn Lys Arg Val Pro Ile 
305                 310                 315                 320 


Leu Pro Phe Val Ile Arg Ala Gly Val Leu Gly Arg Leu Gly Thr Gly 
                325                 330                 335     


Ile Gly Ser Ile Thr Thr Ser Thr Gln Phe Tyr Tyr Lys Leu Ser Gln 
            340                 345                 350         


Glu Ile Asn Gly Asp Met Glu Gln Val Thr Asp Ser Leu Val Thr Leu 
        355                 360                 365             


Gln Asp Gln Leu Asn Ser Leu Ala Ala Val Val Leu Gln Asn Arg Arg 
    370                 375                 380                 


Ala Leu Asp Leu Leu Thr Ala Lys Arg Gly Gly Thr Cys Leu Phe Leu 
385                 390                 395                 400 


Gly Glu Glu Arg Cys Tyr Tyr Val Asn Gln Ser Arg Ile Val Thr Glu 
                405                 410                 415     


Lys Val Lys Glu Ile Arg Asp Arg Ile Gln Cys Arg Ala Glu Glu Leu 
            420                 425                 430         


Gln Asn Thr Glu Arg Trp Gly Leu Leu Ser Gln Trp Met Pro Trp Thr 
        435                 440                 445             


Leu Pro Phe Leu Gly Pro Leu Ala Ala Ile Ile Phe Leu Leu Leu Phe 
    450                 455                 460                 


Gly Pro Cys Ile Phe Asn Phe Leu Val Lys Phe Val Ser Ser Arg Ile 
465                 470                 475                 480 


Glu Ala Val Lys Leu Gln Ile Val Leu Gln Met Glu Pro Gln Met Gln 
                485                 490                 495     


Ser Met Thr Lys Ile Tyr Arg Gly Pro Leu Asp Arg Pro Ala Arg Leu 
            500                 505                 510         


Cys Ser Asp Val Asn Asp Ile Glu Val Thr Pro Pro Glu Glu Ile Ser 
        515                 520                 525             


Thr Ala Gln Pro Leu Leu His Ser Asn Ser Val Gly Ser Ser 
    530                 535                 540         


<210>  10
<211>  11
<212>  PRT
<213>  protein ENV of the Human endogenous retrovirus-W

<400>  10

Leu Phe Asn Thr Thr Leu Thr Arg Leu His Glu 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  protein ENV of the Human endogenous retrovirus-W

<400>  11

Leu Tyr Asn His Val Val Pro 
1               5           


<210>  12
<211>  336
<212>  DNA
<213>  VL

<400>  12
gatattgtga tgacgcaggc tgcattctcc aatccagtca ctcttggaac atcagcttcc       60

atctcctgca ggtctagtaa gagtctccta catagtaagg gcatcactta tttgtattgg      120

tttctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc ccaccttgcc      180

tcaggagtcc cagacaggtt cagtagcagt gggtcaggaa ctgatttcac actgagaatc      240

agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaacttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  13
<211>  348
<212>  DNA
<213>  artificial sequence

<220>
<223>  VH

<400>  13
gaggtccagc tgcagcagtc tgggactgta ctggcaaggc ctggggcttc cgtgaagatg       60

tcctgcaagg cttctggcta cagttttacc agctactgga tgcactggat aaaacagagg      120

cctggacagg gtctagaatg gattggtgct atttatccgg gaaaaagtga tactagctac      180

aaccagaagt ttaagggcaa ggccaagttg actgcggtca catccgccag cactgcctac      240

atggaactca ccagcctgac aaatgaggac tctgcggtct attattgtac aagaaccgtc      300

tatgctatgg actattgggg tcaaggaacc tcagtcaccg tctcctca                   348


