                         SEQUENCE LISTING

<110>  Universitat Autonoma de Barcelona
 
<120>  Fibroblast growth factor 21 (FGF21) gene therapy for central 
       nervous system disorders

<130>  P6092231PCT

<150>  EP 20382442.0
<151>  2020-05-26

<160>  122   

<170>  PatentIn version 3.5

<210>  1
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  2
<211>  210
<212>  PRT
<213>  Mus musculus

<400>  2

Met Glu Trp Met Arg Ser Arg Val Gly Thr Leu Gly Leu Trp Val Arg 
1               5                   10                  15      


Leu Leu Leu Ala Val Phe Leu Leu Gly Val Tyr Gln Ala Tyr Pro Ile 
            20                  25                  30          


Pro Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
        35                  40                  45              


Tyr Leu Tyr Thr Asp Asp Asp Gln Asp Thr Glu Ala His Leu Glu Ile 
    50                  55                  60                  


Arg Glu Asp Gly Thr Val Val Gly Ala Ala His Arg Ser Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
                85                  90                  95      


Val Lys Ala Ser Arg Phe Leu Cys Gln Gln Pro Asp Gly Ala Leu Tyr 
            100                 105                 110         


Gly Ser Pro His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
        115                 120                 125             


Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
    130                 135                 140                 


Leu Arg Leu Pro Gln Lys Asp Ser Pro Asn Gln Asp Ala Thr Ser Trp 
145                 150                 155                 160 


Gly Pro Val Arg Phe Leu Pro Met Pro Gly Leu Leu His Glu Pro Gln 
                165                 170                 175     


Asp Gln Ala Gly Phe Leu Pro Pro Glu Pro Pro Asp Val Gly Ser Ser 
            180                 185                 190         


Asp Pro Leu Ser Met Val Glu Pro Leu Gln Gly Arg Ser Pro Ser Tyr 
        195                 200                 205             


Ala Ser 
    210 


<210>  3
<211>  209
<212>  PRT
<213>  Canis lupus familiaris

<400>  3

Met Gly Trp Ala Glu Ala Gly Phe Glu His Leu Gly Leu Trp Val Pro 
1               5                   10                  15      


Val Leu Ala Val Leu Leu Leu Glu Ala Cys Arg Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Glu Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Ala Asp Gly Thr Val Val Gly Ala Ala Arg Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Gly Pro Asp Gly Thr Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Val Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Ile Tyr His Ser Glu Thr Leu Gly Leu Pro Leu 
    130                 135                 140                 


Arg Leu Arg Pro His Asn Ser Ala Tyr Arg Asp Leu Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Leu Pro Ala Pro Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Glu Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  4
<211>  630
<212>  DNA
<213>  Homo sapiens

<400>  4
atggactcgg acgagaccgg gttcgagcac tcaggactgt gggtttctgt gctggctggt       60

cttctgctgg gagcctgcca ggcacacccc atccctgact ccagtcctct cctgcaattc      120

gggggccaag tccggcagcg gtacctctac acagatgatg cccagcagac agaagcccac      180

ctggagatca gggaggatgg gacggtgggg ggcgctgctg accagagccc cgaaagtctc      240

ctgcagctga aagccttgaa gccgggagtt attcaaatct tgggagtcaa gacatccagg      300

ttcctgtgcc agcggccaga tggggccctg tatggatcgc tccactttga ccctgaggcc      360

tgcagcttcc gggagctgct tcttgaggac ggatacaatg tttaccagtc cgaagcccac      420

ggcctcccgc tgcacctgcc agggaacaag tccccacacc gggaccctgc accccgagga      480

ccagctcgct tcctgccact accaggcctg ccccccgcac tcccggagcc acccggaatc      540

ctggcccccc agccccccga tgtgggctcc tcggaccctc tgagcatggt gggaccttcc      600

cagggccgaa gccccagcta cgcttcctga                                       630


<210>  5
<211>  630
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Homo sapiens FGF21 - variant 1

<400>  5
atggattctg atgagacagg cttcgagcac agcggcctgt gggtttcagt tctggctgga       60

ctgctgctgg gagcctgtca ggcacaccct attccagata gcagccctct gctgcagttc      120

ggcggacaag tgcggcagag atacctgtac accgacgacg cccagcagac agaagcccac      180

ctggaaatca gagaggatgg cacagttggc ggagccgccg atcagtctcc tgaatctctg      240

ctccagctga aggccctgaa gcctggcgtg atccagatcc tgggcgtgaa aaccagccgg      300

ttcctgtgcc aaagacctga cggcgccctg tatggcagcc tgcactttga tcctgaggcc      360

tgcagcttca gagagctgct gcttgaggac ggctacaacg tgtaccagtc tgaggcccat      420

ggcctgcctc tgcatctgcc tggaaacaag agccctcaca gagatcccgc tcctagaggc      480

cctgccagat ttctgcctct tcctggattg cctcctgctc tgccagagcc tcctggaatt      540

ctggctcctc agcctcctga tgtgggcagc tctgatcctc tgagcatggt cggacctagc      600

cagggcagat ctcctagcta cgcctcttga                                       630


<210>  6
<211>  630
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Homo sapiens FGF21 - variant 2

<400>  6
atggacagcg atgaaaccgg gttcgagcac agcggtctgt gggtgtccgt gctggccgga       60

ctgctcctgg gagcctgtca ggcgcacccc atccctgact cctcgccgct gctgcaattc      120

ggcggacaag tccgccagag atacctgtac accgacgacg cccagcagac cgaagcccac      180

ctggaaattc gggaggacgg gactgtggga ggcgctgcag atcagtcacc cgagtccctc      240

ctccaactga aggccttgaa gcccggcgtg attcagatcc tgggcgtgaa aacttcccgc      300

ttcctttgcc aacggccgga tggagctctg tacggatccc tgcacttcga ccccgaagcc      360

tgctcattcc gcgagctgct ccttgaggac ggctataacg tgtaccagtc tgaggcccat      420

ggactccccc tgcatctgcc cggcaacaag tcccctcacc gggatcctgc cccaagaggc      480

ccagctcggt ttctgcctct gccgggactg cctccagcgt tgcccgaacc ccctggtatc      540

ctggccccgc aaccacctga cgtcggttcg tcggacccgc tgagcatggt cggtccgagc      600

cagggaaggt ccccgtccta cgcatcctga                                       630


<210>  7
<211>  630
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Homo sapiens FGF21 - variant 3

<400>  7
atggattccg acgaaactgg atttgaacat tcagggctgt gggtctctgt gctggctgga       60

ctgctgctgg gggcttgtca ggctcacccc atccctgaca gctcccctct gctgcagttc      120

ggaggacagg tgcggcagag atacctgtat accgacgatg cccagcagac agaggcacac      180

ctggagatca gggaggacgg aaccgtggga ggagcagccg atcagtctcc cgagagcctg      240

ctgcagctga aggccctgaa gcctggcgtg atccagatcc tgggcgtgaa gacatctcgg      300

tttctgtgcc agcggcccga cggcgccctg tacggctccc tgcacttcga tcccgaggcc      360

tgttctttta gggagctgct gctggaggac ggctacaacg tgtatcagag cgaggcacac      420

ggcctgccac tgcacctgcc tggcaataag tcccctcacc gcgatccagc acccaggggc      480

ccagcacgct tcctgcctct gccaggcctg ccccctgccc tgccagagcc acccggcatc      540

ctggcccccc agcctccaga tgtgggctcc agcgatcctc tgtcaatggt ggggccaagt      600

caggggcgga gtccttcata cgcatcataa                                       630


<210>  8
<211>  633
<212>  DNA
<213>  Mus musculus

<400>  8
atggaatgga tgagatctag agttgggacc ctgggactgt gggtccgact gctgctggct       60

gtcttcctgc tgggggtcta ccaagcatac cccatccctg actccagccc cctcctccag      120

tttgggggtc aagtccggca gaggtacctc tacacagatg acgaccaaga cactgaagcc      180

cacctggaga tcagggagga tggaacagtg gtaggcgcag cacaccgcag tccagaaagt      240

ctcctggagc tcaaagcctt gaagccaggg gtcattcaaa tcctgggtgt caaagcctct      300

aggtttcttt gccaacagcc agatggagct ctctatggat cgcctcactt tgatcctgag      360

gcctgcagct tcagagaact gctgctggag gacggttaca atgtgtacca gtctgaagcc      420

catggcctgc ccctgcgtct gcctcagaag gactccccaa accaggatgc aacatcctgg      480

ggacctgtgc gcttcctgcc catgccaggc ctgctccacg agccccaaga ccaagcagga      540

ttcctgcccc cagagccccc agatgtgggc tcctctgacc ccctgagcat ggtagagcct      600

ttacagggcc gaagccccag ctatgcgtcc tga                                   633


<210>  9
<211>  633
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Mus musculus FGF21

<400>  9
atggaatgga tgagaagcag agtgggcacc ctgggcctgt gggtgcgact gctgctggct       60

gtgtttctgc tgggcgtgta ccaggcctac cccatccctg actctagccc cctgctgcag      120

tttggcggac aagtgcggca gagatacctg tacaccgacg acgaccagga caccgaggcc      180

cacctggaaa tccgcgagga tggcacagtc gtgggcgctg ctcacagaag ccctgagagc      240

ctgctggaac tgaaggccct gaagcccggc gtgatccaga tcctgggcgt gaaggccagc      300

agattcctgt gccagcagcc tgacggcgcc ctgtacggct ctcctcactt cgatcctgag      360

gcctgcagct tcagagagct gctgctggag gacggctaca acgtgtacca gtctgaggcc      420

cacggcctgc ccctgagact gcctcagaag gacagcccta accaggacgc cacaagctgg      480

ggacctgtgc ggttcctgcc tatgcctgga ctgctgcacg agccccagga tcaggctggc      540

tttctgcctc ctgagcctcc agacgtgggc agcagcgacc ctctgagcat ggtggaacct      600

ctgcagggca gaagccccag ctacgcctct tga                                   633


<210>  10
<211>  629
<212>  DNA
<213>  Canis lupus familiaris

<400>  10
atgggctggg ccgaggccgg gttcgagcac ctgggactgt gggtccctgt gctggctgtg       60

cttttgctgg aagcctgccg ggcacatccg atccctgact ccagccccct cctacaattt      120

ggaggtcaag ttcgacagcg gtacctctac accgacgatg cccaggagac agaggcccac      180

ctagagatca gggccgatgg cacagggtgg gggctgcccg ccagagccct gaaagtctcc      240

tggagctgaa agccctaaag ccaggggtca ttcaaatctt gggagtcaaa acatccaggt      300

tcctgtgcca gggcccagat gggacactat atggctcgct ccatttcgac cctgtggcct      360

gcagtttccg agaactgctt cttgaggatg ggtacaacat ctaccactcc gagacccttg      420

gtctcccgct tcgcctgcgc ccccacaact ccgcataccg ggacttggca ccccgcgggc      480

ctgcccgctt cctgccactg ccaggcctgc ttccagcacc cccagagcct ccagggatcc      540

tggccccgga gcctcctgac gtgggctcct cggaccctct gagcatggtg gggccttcac      600

agggccggag tcccagctat gcttcctaa                                        629


<210>  11
<211>  630
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Codon optimized Canis lupus familiaris FGF21

<400>  11
atgggatggg ctgaggctgg attcgaacac ctgggactct gggtgcccgt cctggccgtg       60

ctgctcctgg aggcttgcag ggctcatccc atccctgaca gctccccact cctgcagttt      120

ggaggacagg tgaggcagcg gtacctgtat accgacgatg cccaggagac agaagctcac      180

ctggaaattc gggctgatgg aacagtggtc ggagctgccc gacagtcccc agagtctctc      240

ctggaactga aggccctcaa acccggagtg atccagattc tgggcgtcaa gacttctaga      300

ttcctgtgcc agggaccaga cggcaccctg tacggcagcc tgcatttcga tcctgtggcc      360

tgttcctttc gagagctcct gctcgaagac ggctacaaca tctatcactc tgagaccctg      420

ggactcccac tgcgactcag acctcataat agtgcctatc gagatctggc tcccaggggc      480

ccagctaggt ttctgccact ccccggactg ctccctgctc cacctgagcc acccggcatt      540

ctggctccag aacctccaga cgtgggctct agtgatccac tgagtatggt cggcccctca      600

caggggaggt cacctagcta cgccagctga                                       630


<210>  12
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-122a

<400>  12
caaacaccat tgtcacactc ca                                                22


<210>  13
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-1

<400>  13
ttacatactt ctttacattc ca                                                22


<210>  14
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-152

<400>  14
ccaagttctg tcatgcactg a                                                 21


<210>  15
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-199a-5p

<400>  15
gaacaggtag tctgaacact ggg                                               23


<210>  16
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-199a-3p

<400>  16
taaccaatgt gcagactact gt                                                22


<210>  17
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-215

<400>  17
gtctgtcaat tcataggtca t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-192

<400>  18
ggctgtcaat tcataggtca g                                                 21


<210>  19
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-148a

<400>  19
acaaagttct gtagtgcact ga                                                22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-194

<400>  20
tccacatgga gttgctgtta ca                                                22


<210>  21
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-133a

<400>  21
cagctggttg aaggggacca aa                                                22


<210>  22
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-206

<400>  22
ccacacactt ccttacattc ca                                                22


<210>  23
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-208a-5p

<400>  23
gtataacccg ggccaaaagc tc                                                22


<210>  24
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-208a-3p

<400>  24
acaagctttt tgctcgtctt at                                                22


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miRT-499-5p

<400>  25
aaacatcact gcaagtctta a                                                 21


<210>  26
<211>  133
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric intron composed of introns from human beta-globin and 
       immunoglobulin heavy chain genes

<400>  26
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  27
<211>  1671
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CAG promoter

<400>  27
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gttgccttcg ccccgtgccc cgctccgcgc cgcctcgcgc cgcccgcccc      720

ggctctgact gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg      780

gctgtaatta gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc      840

ttgaggggct ccgggagggc cctttgtgcg gggggagcgg ctcggggggt gcgtgcgtgt      900

gtgtgtgcgt ggggagcgcc gcgtgcggct ccgcgctgcc cggcggctgt gagcgctgcg      960

ggcgcggcgc ggggctttgt gcgctccgca gtgtgcgcga ggggagcgcg gccgggggcg     1020

gtgccccgcg gtgcgggggg ctgcgagggg aacaaaggct gcgtgcgggg tgtgtgcgtg     1080

ggggggtgag cagggggtgt gggcgcgtcg gtcgggctgc aaccccccct gcacccccct     1140

ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc tccgtacggg gcgtggcgcg     1200

gggctcgccg tgccgggcgg ggggtggcgg caggtggggg tgccgggcgg ggcggggccg     1260

cctcgggccg gggagggctc gggggagggg cgcggcggcc cccggagcgc cggcggctgt     1320

cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat cgtgcgagag ggcgcaggga     1380

cttcctttgt cccaaatctg tgcggagccg aaatctggga ggcgccgccg caccccctct     1440

agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt     1500

cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc ctcggggctg tccgcggggg     1560

gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc     1620

ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca g              1671


<210>  28
<211>  212
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMV promoter

<400>  28
gtgatgcggt tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctgcgatcgc ccgccccgtt gacgcaaatg ggcggtaggc      180

gtgtacggtg ggaggtctat ataagcagag ct                                    212


<210>  29
<211>  380
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMV enhancer

<400>  29
ggcattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  30
<211>  128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Truncated AAV2 5' ITR

<400>  30
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttcct                                                               128


<210>  31
<211>  128
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Truncated AAV2 3' ITR

<400>  31
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgc                                                               128


<210>  32
<211>  122
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SV40 polyadenylation signal

<400>  32
taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta       60

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag      120

tt                                                                     122


<210>  33
<211>  449
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Rabbit beta-globin polyadenylation signal

<400>  33
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga gtatttggtt      180

tagagtttgg caacatatgc ccatatgctg gctgccatga acaaaggttg gctataaaga      240

ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag aaaagccttg      300

acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt aacatcccta      360

aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact actcccagtc      420

atagctgtcc ctcttctctt atggagatc                                        449


<210>  34
<211>  592
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CMV promoter and CMV enhancer sequence

<400>  34
ggcattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctgcgatcgc ccgccccgtt      540

gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ct              592


<210>  35
<211>  7319
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-CAG-moFGF21-dmiRT

<400>  35
agtgagcgag cgagcgcgca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt       60

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg      120

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg      180

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag      240

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga      300

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct      360

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc      420

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg      480

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc      540

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca      600

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag      660

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct      720

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc      780

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga      840

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca      900

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat      960

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     1020

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     1080

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     1140

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     1200

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     1260

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     1320

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     1380

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     1440

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     1500

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     1560

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     1620

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     1680

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     1740

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     1800

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     1860

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     1920

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     1980

cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta     2040

acctataaaa ataggcgtat cacgaggccc tttcgtctcg cgcgtttcgg tgatgacggt     2100

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2160

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt     2220

aactatgcgg catcagagca gattgtactg agagtgcacc atatgcggtg tgaaataccg     2280

cacagatgcg taaggagaaa ataccgcatc aggcgattcc aacatccaat aaatcataca     2340

ggcaaggcaa agaattagca aaattaagca ataaagcctc agagcataaa gctaaatcgg     2400

ttgtaccaaa aacattatga ccctgtaata cttttgcggg agaagccttt atttcaacgc     2460

aaggataaaa atttttagaa ccctcatata ttttaaatgc aatgcctgag taatgtgtag     2520

gtaaagattc aaacgggtga gaaaggccgg agacagtcaa atcaccatca atatgatatt     2580

caaccgttct agctgataaa ttcatgccgg agagggtagc tatttttgag aggtctctac     2640

aaaggctatc aggtcattgc ctgagagtct ggagcaaaca agagaatcga tgaacggtaa     2700

tcgtaaaact agcatgtcaa tcatatgtac cccggttgat aatcagaaaa gccccaaaaa     2760

caggaagatt gtataagcaa atatttaaat tgtaagcgtt aatattttgt taaaattcgc     2820

gttaaatttt tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc     2880

ttataaatca aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag     2940

tccactatta aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga     3000

tggcccacta cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc     3060

actaaatcgg aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa     3120

cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt     3180

agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc     3240

gtactatggt tgctttgacg agcacgtata acgtgctttc ctcgttagaa tcagagcggg     3300

agctaaacag gaggccgatt aaagggattt tagacaggaa cggtacgcca gaatcctgag     3360

aagtgttttt ataatcagtg aggccaccga gtaaaagagt ctgtccatca cgcaaattaa     3420

ccgttgtcgc aatacttctt tgattagtaa taacatcact tgcctgagta gaagaactca     3480

aactatcggc cttgctggta atatccagaa caatattacc gccagccatt gcaacggaat     3540

cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcc     3600

actgaggccc agctgcgcgc tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt     3660

cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc     3720

aactccatca ctaggggttc cttgtagtta atgattaacc cgccatgcta cttatctact     3780

cgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc     3840

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc     3900

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg     3960

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat     4020

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc     4080

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta     4140

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc     4200

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg     4260

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg     4320

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt     4380

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg     4440

ggagtcgctg cgttgccttc gccccgtgcc ccgctccgcg ccgcctcgcg ccgcccgccc     4500

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg     4560

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc     4620

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg     4680

tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc     4740

gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc     4800

ggtgccccgc ggtgcggggg gctgcgaggg gaacaaaggc tgcgtgcggg gtgtgtgcgt     4860

gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc tgcacccccc     4920

tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg ggcgtggcgc     4980

ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg gggcggggcc     5040

gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg ccggcggctg     5100

tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga gggcgcaggg     5160

acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc gcaccccctc     5220

tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg gggagggcct     5280

tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct gtccgcgggg     5340

ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg     5400

cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg     5460

caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattgatta attcgagcga     5520

acgcgtcgag tcgctcggta cgatttaaat tgaattggcc tcgagcgcaa gcttgagcta     5580

gcgccaccat ggaatggatg agaagcagag tgggcaccct gggcctgtgg gtgcgactgc     5640

tgctggctgt gtttctgctg ggcgtgtacc aggcctaccc catccctgac tctagccccc     5700

tgctgcagtt tggcggacaa gtgcggcaga gatacctgta caccgacgac gaccaggaca     5760

ccgaggccca cctggaaatc cgcgaggatg gcacagtcgt gggcgctgct cacagaagcc     5820

ctgagagcct gctggaactg aaggccctga agcccggcgt gatccagatc ctgggcgtga     5880

aggccagcag attcctgtgc cagcagcctg acggcgccct gtacggctct cctcacttcg     5940

atcctgaggc ctgcagcttc agagagctgc tgctggagga cggctacaac gtgtaccagt     6000

ctgaggccca cggcctgccc ctgagactgc ctcagaagga cagccctaac caggacgcca     6060

caagctgggg acctgtgcgg ttcctgccta tgcctggact gctgcacgag ccccaggatc     6120

aggctggctt tctgcctcct gagcctccag acgtgggcag cagcgaccct ctgagcatgg     6180

tggaacctct gcagggcaga agccccagct acgcctcttg agaatgcggg cccggtaccc     6240

ccgacgcggc cgctaattct agatcgcgaa caaacaccat tgtcacactc cagtatacac     6300

aaacaccatt gtcacactcc agatatcaca aacaccattg tcacactcca aggcgaacaa     6360

acaccattgt cacactccaa ggctattcta gatcgcgaat tacatacttc tttacattcc     6420

agtatacatt acatacttct ttacattcca gatatcatta catacttctt tacattccaa     6480

ggcgaattac atacttcttt acattccaag gctacctgag gcccgggggt acctcttaat     6540

taactggcct catgggcctt ccgctcactg cccgctttcc agtcgggaaa cctgtcgtgc     6600

cagtcaggtg caggctgcct atcagaaggt ggtggctggt gtggccaatg ccctggctca     6660

caaataccac tgagatcttt ttccctctgc caaaaattat ggggacatca tgaagcccct     6720

tgagcatctg acttctggct aataaaggaa atttattttc attgcaatag tgtgttggaa     6780

ttttttgtgt ctctcactcg gaaggacata tgggagggca aatcatttaa aacatcagaa     6840

tgagtatttg gtttagagtt tggcaacata tgcccatatg ctggctgcca tgaacaaagg     6900

ttggctataa agaggtcatc agtatatgaa acagccccct gctgtccatt ccttattcca     6960

tagaaaagcc ttgacttgag gttagatttt ttttatattt tgttttgtgt tatttttttc     7020

tttaacatcc ctaaaatttt ccttacatgt tttactagcc agatttttcc tcctctcctg     7080

actactccca gtcatagctg tccctcttct cttatggaga tccctcgacc tgcagcccaa     7140

gctgtagata agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag     7200

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     7260

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctggcgtaa      7319


<210>  36
<211>  411
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mini-CMV promoter

<400>  36
tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc       60

ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc      120

tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc      180

acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa      240

tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag      300

gcgtgtacgg tgggaggtct atataagcag agctctctgg ctaactagag aacccactgc      360

ttaactggct tatcgaaatt aatacgactc actataggga gacccaagct t               411


<210>  37
<211>  1178
<212>  DNA
<213>  Artificial sequence

<220>
<223>  EF1alpha promoter

<400>  37
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc      240

gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt      300

acttccactg gctgcagtac gtgattcttg atcccgagct tcgggttgga agtgggtggg      360

agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt gaggcctggc      420

ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt      480

tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt tttttctggc      540

aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt tttggggccg      600

cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag      660

cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg      720

gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg tcggcaccag      780

ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca aaatggagga      840

cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg gcctttccgt      900

cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg cacctcgatt      960

agttctcgag cttttggagt acgtcgtctt taggttgggg ggaggggttt tatgcgatgg     1020

agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac ttgatgtaat     1080

tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag cctcagacag     1140

tggttcaaag tttttttctt ccatttcagg tgtcgtga                             1178


<210>  38
<211>  623
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RSV promoter

<400>  38
catgtttgac agcttatcat cgcagatccg tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat tcgcgtatct      240

gaggggacta gggtgtgttt aggcgaaaag cggggcttcg gttgtacgcg gttaggagtc      300

ccctcaggat atagtagttt cgcttttgca tagggagggg gaaatgtagt cttatgcaat      360

actcttgtag tcttgcaaca tggtaacgat gagttagcaa catgccttac aaggagagaa      420

aaagcaccgt gcatgccgat tggtggaagt aaggtggtac gatcgtgcct tattaggaag      480

gcaacagacg ggtctgacat ggattggacg aaccactaaa ttccgcattg cagagatatt      540

gtatttaagt gcctagctcg atacaataaa cgccatttga ccattcacca cattggtgtg      600

cacctccaag ctgggtacca gct                                              623


<210>  39
<211>  448
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synapsin 1 promoter

<400>  39
ctgcgctctc aggcacgaca cgactcctcc gctgcccacc gcagactgag gcagcgctga       60

gtcgccggcg ccgcagcgca gatggtcgcg cccgtgcccc cctatctcgc gcctcgcgtg      120

gtgcggtccg gctgggccgg cggcggcgcg gacgcgacca aggtggccgg gaaggggagt      180

ttgcggggga ccggcgagtg acgtcagcgc gccttcagtg ctgaggcggc ggtggcgcgc      240

gccgccaggc gggggcgaag gcactgtccg cggtgctgaa gctggcagtg cgcacgcgcc      300

tcgccgcatc ctgtttcccc tccccctctc tgatagggga tgcgcaattt ggggaatggg      360

ggttgggtgc ttgtccagtg ggtcggggtc ggtcgtcagg taggcacccc caccccgcct      420

catcctggtc ctaaaaccca cttgcact                                         448


<210>  40
<211>  1296
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Calcium/calmodulin-dependent protein kinase II (CaMKII) promoter

<400>  40
taacattatg gccttaggtc acttcatctc catggggttc ttcttctgat tttctagaaa       60

atgagatggg ggtgcagaga gcttcctcag tgacctgccc agggtcacat cagaaatgtc      120

agagctagaa cttgaactca gattactaat cttaaattcc atgccttggg ggcatgcaag      180

tacgatatac agaaggagtg aactcattag ggcagatgac caatgagttt aggaaagaag      240

agtccagggc agggtacatc tacaccaccc gcccagccct gggtgagtcc agccacgttc      300

acctcattat agttgcctct ctccagtcct accttgacgg gaagcacaag cagaaactgg      360

gacaggagcc ccaggagacc aaatcttcat ggtccctctg ggaggatggg tggggagagc      420

tgtggcagag gcctcaggag gggccctgct gctcagtggt gacagatagg ggtgagaaag      480

cagacagagt cattccgtca gcattctggg tctgtttggt acttcttctc acgctaaggt      540

ggcggtgtga tatgcacaat ggctaaaaag cagggagagc tggaaagaaa caaggacaga      600

gacagaggcc aagtcaacca gaccaattcc cagaggaagc aaagaaacca ttacagagac      660

tacaaggggg aagggaagga gagatgaatt agcttcccct gtaaacctta gaacccagct      720

gttgccaggg caacggggca atacctgtct cttcagagga gatgaagttg ccagggtaac      780

tacatcctgt ctttctcaag gaccatccca gaatgtggca cccactagcc gttaccatag      840

caactgcctc tttgccccac ttaatcccat cccgtctgtt aaaagggccc tatagttgga      900

ggtgggggag gtaggaagag cgatgatcac ttgtggacta agtttgttcg catccccttc      960

tccaaccccc tcagtacatc accctggggg aacagggtcc acttgctcct gggcccacac     1020

agtcctgcag tattgtgtat ataaggccag ggcaaagagg agcaggtttt aaagtgaaag     1080

gcaggcaggt gttggggagg cagttaccgg ggcaacggga acagggcgtt tcggaggtgg     1140

ttgccatggg gacctggatg ctgacgaagg ctcgcgaggc tgtgagcagc cacagtgccc     1200

tgctcagaag ccccaagctc gtcagtcaag ccggttctcc gtttgcactc aggagcacgg     1260

gcaggcgagt ggcccctagt tctgggggca gcgggg                               1296


<210>  41
<211>  706
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Glial fibrillary acidic protein (GFAP) promoter

<400>  41
cgcgtgatct aacatatcct ggtgtggagt aggggacgct gctctgacag aggctcgggg       60

gcctgagctg gctctgtgag ctggggagga ggcagacagc caggccttgt ctgcaagcag      120

acctggcagc attgggctgg ccgcccccca gggcctcctc ttcatgccca gtgaatgact      180

caccttggca cagacacaat gttcggggtg ggcacagtgc ctgcttcccg ccgcacccca      240

gcccccctca aatgccttcc gagaagccca ttgagcaggg ggcttgcatt gcaccccagc      300

ctgacagcct ggcatcttgg gataaaagca gcacagcccc ctaggggctg cccttgctgt      360

gtggcgccac cggcggtgga gaacaaggct ctattcagcc tgtgcccagg aaaggggatc      420

aggggatgcc caggcatgga cagtgggtgg caggggggga gaggagggct gtctgcttcc      480

cagaagtcca aggacacaaa tgggtgaggg gagagctctc cccatagctg ggctgcggcc      540

caaccccacc ccctcaggct atgccagggg gtgttgccag gggcacccgg gcatcgccag      600

tctagcccac tccttcataa agccctcgca tcccaggagc gagcagagcc agagcaggtt      660

ggagaggaga cgcatcacct ccgctgctcg cggggtctag agtcga                     706


<210>  42
<211>  1153
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nestin promoter

<400>  42
gaaggcagcc cccggaggtc aaaggctggg cacgcgggag gagaggccag agtcagaggc       60

tgcgggtatc tcagatatga aggaaagatg agagaggctc aggaagaggt aagaaaagac      120

acaagagacc agagaaggga gaagaattag agagggaggc agaggaccgc tgtctctaca      180

gacatagctg gtagagactg ggaggaaggg atgaaccctg agcgcatgaa gggaaggagg      240

tggctggtgg tatatggagg atgtagctgg gccagggaaa agatcctgca ctaaaaatct      300

gaagctaaaa ataacaggac acggggtgga gaggcgaaag gagggcagat tgaggcagag      360

agactgagag gcctggggat gtgggcattc cggtagggca cacagttcac ttgtcttctc      420

tttttccagg aggccaaaga tgctgacctc aagaactcat aataccccag tggggaccac      480

cgcattcata gccctgttac aagaagtggg agatgttcct ttttgtccca gactggaaat      540

ccattacatc ccgaggctca ggttctgtgg tggtcatctc tgtgtggctt gttctgtggg      600

cctacctaaa gtcctaagca cagctctcaa gcagatccga ggcgactaag atgctagtag      660

gggttgtctg gagagaagag ccgaggaggt gggctgtgat ggatcagttc agctttcaaa      720

taaaaaggcg tttttatatt ctgtgtcgag ttcgtgaacc cctgtggtgg gcttctccat      780

ctgtctgggt tagtacctgc cactatactg gaataaggag acgcctgctt ccctcgagtt      840

ggctggacaa ggttatgagc atccgtgtac ttatggggtt gccagcttgg tcctggatcg      900

cccgggccct tcccccaccc gttcggttcc ccaccaccac ccgcgctcgt acgtgcgtct      960

ccgcctgcag ctcttgactc atcggggccc ccgggtcaca tgcgctcgct cggctctata     1020

ggcgccgccc cctgcccacc ccccgcccgc gctgggagcc gcagccgccg ccactcctgc     1080

tctctctgcg ccgccgccgt caccaccgcc accgccaccg gctgagtctg cagtcctccg     1140

aaacgggccc tct                                                        1153


<210>  43
<211>  438
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Homeobox Protein 9 promoter (HB9) promoter

<400>  43
tgaataaatt taagcaggct aattaatata taaactagct caatttgtca agttgatttg       60

tattttagtt aattgtgaaa gtaattacca catggtcaaa ttaacagctt tctggaaatg      120

accaagcctg aggttttatt tccttcctgg gtgaagaaaa ttcatttttc caagctcttg      180

atgtgatgaa taaaagtcat aaatctgggt gattggtgca ggcagagtct aaatggcttc      240

atatttcatt ttaggtttaa tagaaatatt catgctctgt tttaatgaaa ttaaattgaa      300

gggggatggg gctagagtgg ttagctgatg aattgacaaa aactaatcag ctttattggg      360

aaacaggttt aagggcacgg acgtgtcaat aacgctcagc ctgaccccct cttccattag      420

ctaggcaggc tgattaga                                                    438


<210>  44
<211>  3015
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Tyrosine hydroxylase (TH) promoter

<400>  44
ctgctagggg ctgcttccca gctactcctc ttggctccgt ggcttgcctt ccagcctgtg       60

tgctgtctgg agagccttta aagcctcact tccaccaact agaagtctct ccccaaccct      120

gccctgacct caagtgcacc tcttcaaagt caggtttagc agctgcagct gggggccctg      180

aatcccaccc ctgctgtctt ccttgaagac agaagtgttg ggagctgagg atctgggcta      240

gagactggct gtatgatcca gagaagtagt gtgcttctgg gcctcagatt tcccttctgt      300

agaacaggtt tgtctgaaat ggagaggttg gtgctcctct gcagggccta gtgggagtca      360

ccatgagtgg ttaaaagatc cagcttgtct tttggtgagc tttgagagga ggtaacaggg      420

ctgagttctg gaagcctgac caagggcaga cttaaggggc ctcttggagt tgttctcatc      480

aaatggggat gggacacagc taaagtgccc agggcttctc tgtgcccaca gatgctttag      540

atcttggcac agtgtggtct accagctgtc tctctctgtg tatatatatg tatttcatag      600

acagtgtaca gtggcctggt ttgtgctatc aggctggata tggacagagg caagagtttg      660

tggcagcagt tatctcccaa gagagtccaa agacatcatg ttttcaagtt taggccaggt      720

gctacttgag agagctcaga cacagacaaa ggtctggaga gcacatgtcc tccaccccca      780

cctagcttct gttgcaagca cctccagccg agacaagaga acgaattaaa aagcaatatt      840

tgtgtcagtg taagacattt gccgaaaggt taaatccaca ttcgtgttgc tgcagagcag      900

ccccctatgc aggatttgtt agatacagct ccgtcctacc ctgtgccagc tgagcaaacg      960

ccaggctggg tggggtggaa cccagcctgg gtttgcctca ccctgcaatc cccccagcac     1020

cctctaaagg aggaccctgt ggtgggcatg cagacctagg gactgggcat agataacctt     1080

tgggtttggg caacagcccc cactcctcag gattgaaggc taaggtgcag ccagctctgc     1140

cttcatggtg ggaatgtctc cacgtgaccc ctttctgggc tgtggagaac actcagagaa     1200

gagtcctggg atgccaggca ggccagggat gtgctgggca tgttgagaca ggagtgggct     1260

aagccagcag agttgctgac ccaggaagag ttcagaaagg ggcatggaac atggggaggg     1320

gtccatagtg agagagagca ggcagtgcag agtaaatagt ccctgagctg ggggttatgg     1380

gatttgcagg agcttgctca gagaaggcag aggagagatg ctgcgccaag ctgggtatca     1440

cagagcctca gactcctgga acaggaactg tgggggtcag gtcagcaggg gaggttaggg     1500

agtgttccct ttgtactgac ttagcattta tcctgcttct aggggggaag gggggccagt     1560

gggggatgca cagcaaggca gtgatgtggc aggcagcctg cgggagctcc tggttcctgg     1620

tgtgaaaaag ctgggaagga agagggctgg gtctggtaag tacagcaggc agttggctcc     1680

tgagagtcca agccctgtct agagggtgga gtgagatttc agagggagag ctaaacgggg     1740

tgggggctgg ggagtccagg cttctggctc ctgctaatac tcagtgtgct gggtcctcag     1800

aacctcaggg tggccatttt cagggtgaga gctctgtcct ttggcacttc tgcagactcc     1860

agtatccaga ggaataaaga tggtactctt cctcagttcc cttagtgaga ggacaccttt     1920

ctctgaaggg cttgggcagt tgtcctgaac cattgcctga aggaaggact tgactccagg     1980

gacatagaat gggctcagca taagtcccct gtagtagaga aaggtcccct ctctggtctc     2040

cttagagatc ctgtttcctt ggctgaggaa gctagggtgg atctttgtgt aagtgggtgt     2100

ggatgctcac tggaaatcaa aaggcccctt ggtgttagac cttggggtgc catgggagag     2160

ttgatcactg agtgcgccct tacatggggg ccagctgaga atggggctgc ctctagctcg     2220

agaccatgat gcagggagtg agtgggggag ttcaggatac tcttaactaa agcagaggtc     2280

tgtcccccca gggaggggag gtcagaagac cctagggaga tgccaaaggc tagggttggc     2340

accatgttgc aggctgtgtc ttcaaggaga tgataatcag aggaatcgaa cctgcaaaag     2400

tgggccagtc ttagatacac tatagaggaa taatcttctg aaacattctg tgtctcatag     2460

gacctgcctg aggacccagc cccagtgcca gcacatacac tggggcagtg agtagatagt     2520

atactttgtt acatgggctg gggggacatg gcctgtgccc tggaggggac ttgaagacat     2580

ccaaaaagct agtgagaggg ctcctagatt tatttgtctc caagggctat atatagcctt     2640

cctaacatga acccttgggt aatccagcat gggcgctccc atatgccctg gtttgattag     2700

agagctctag atgtctcctg tcccagaaca ccagccagcc cctgtcttca tgtcgtgtct     2760

agggcggagg gtgattcaga ggcaggtgcc tgcgacagtg gatgcaatta gatctaatgg     2820

gacggaggcc tctctcgtcc gtcgccctcg ctctgtgccc acccccgcct ccctcaggca     2880

cagcaggcgt ggagaggatg cgcaggaggt aggaggtggg ggacccagag gggctttgac     2940

gtcagcctgg cctttaagag gccgcctgcc tggcaagggc cgtggagaca gaactcggga     3000

ccaccagctt gcact                                                      3015


<210>  45
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Myelin basic protein (MBP) promoter

<400>  45
caccgtggct ttaacactta gagaaaatgc atcccctcta atcaataagt catcgacagt       60

gggtagatgg aggaacggca gtgcgtagta ggatgcgtgc aagcatagtc tcgtgcatgg      120

gtgcatagat cgctgggcag gtggacaagg tgggggtgga taaagaagtg ggtagatgat      180

tgatgttagg taaatatcac tgggtggaca gatgggtggt aggtggatgg atggttagaa      240

tagtcagaag agggatggat tgataaggtg aacagatgat aaatgggtga tagactggaa      300

gggttgtcaa aagaggataa gggaagtgtg agctagccgt atttctaagg tcagtaatag      360

agttgggaga agaggttaag ttacatccat ttaaacctca cacgaagctg agagggaatg      420

gacttgctgc cgttggtgag gaaagcgttg catttcccgt gtgcttggtt gtgaagtgct      480

caggtcccac atgaagcagt caggttactg cggcttacag aggagccaga tccaaatgcc      540

ccgagtaagc acgtccccga gccagaggcc tccagcggaa tccgggagag ggattgctca      600

gtgccctgct tccctggact gtaagctgca gaaagatgtg ggaagtcctg ttctccactg      660

agaacactaa aagcaccttt tgtcaaacga ccgcttcaca tctggggctt gtgcactggt      720

ggccttttaa accagagaca acccacaaga tacctaacct gcggggctct ctggtacagt      780

gagcaactca ggaaatgctt tggcttgatt gctgtgggct ctcaggccat cgccctctgg      840

agtggttctt ttaatgagaa cctgaagatt ggcccctgag ccatgtatac caagcaagct      900

caatccaggt tagctccctc tggttggggc aagctaacgt gctccttggg ccccgcgcgt      960

aactgtgcgt tttataggag acagctagtt caagacccca ggaagaaagc ggctttgtcc     1020

ccctctaggc ctcgtacagg cccacattca tatctcattg ttgttgcagg ggaggcagat     1080

gcgatccaga acaatgggac ctcggctgag gacacggcgg tgacagactc caagcacaca     1140

gcagacccaa agaataactg gcaaggcgcc cacccagctg acccagggaa ccgcccccac     1200

ttgatccgcc tcttttcccg agatgccccg ggaagggagg acaacacctt caaagacagg     1260

ccctcagagt ccgacgagct tcagaccatc caagaagatc ccacagcagc ttccgaagaa     1320

ttctgcagtc gacggtaccg cgggcccggg atc                                  1353


<210>  46
<211>  7030
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-CAG-moFGF21

<400>  46
agtgagcgag cgagcgcgca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt       60

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg      120

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg      180

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag      240

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga      300

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct      360

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc      420

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg      480

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc      540

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca      600

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag      660

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct      720

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc      780

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga      840

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca      900

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat      960

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     1020

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     1080

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     1140

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     1200

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     1260

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     1320

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     1380

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     1440

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     1500

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     1560

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     1620

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     1680

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     1740

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     1800

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     1860

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     1920

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     1980

cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta     2040

acctataaaa ataggcgtat cacgaggccc tttcgtctcg cgcgtttcgg tgatgacggt     2100

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2160

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt     2220

aactatgcgg catcagagca gattgtactg agagtgcacc atatgcggtg tgaaataccg     2280

cacagatgcg taaggagaaa ataccgcatc aggcgattcc aacatccaat aaatcataca     2340

ggcaaggcaa agaattagca aaattaagca ataaagcctc agagcataaa gctaaatcgg     2400

ttgtaccaaa aacattatga ccctgtaata cttttgcggg agaagccttt atttcaacgc     2460

aaggataaaa atttttagaa ccctcatata ttttaaatgc aatgcctgag taatgtgtag     2520

gtaaagattc aaacgggtga gaaaggccgg agacagtcaa atcaccatca atatgatatt     2580

caaccgttct agctgataaa ttcatgccgg agagggtagc tatttttgag aggtctctac     2640

aaaggctatc aggtcattgc ctgagagtct ggagcaaaca agagaatcga tgaacggtaa     2700

tcgtaaaact agcatgtcaa tcatatgtac cccggttgat aatcagaaaa gccccaaaaa     2760

caggaagatt gtataagcaa atatttaaat tgtaagcgtt aatattttgt taaaattcgc     2820

gttaaatttt tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc     2880

ttataaatca aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag     2940

tccactatta aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga     3000

tggcccacta cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc     3060

actaaatcgg aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa     3120

cgtggcgaga aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt     3180

agcggtcacg ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc     3240

gtactatggt tgctttgacg agcacgtata acgtgctttc ctcgttagaa tcagagcggg     3300

agctaaacag gaggccgatt aaagggattt tagacaggaa cggtacgcca gaatcctgag     3360

aagtgttttt ataatcagtg aggccaccga gtaaaagagt ctgtccatca cgcaaattaa     3420

ccgttgtcgc aatacttctt tgattagtaa taacatcact tgcctgagta gaagaactca     3480

aactatcggc cttgctggta atatccagaa caatattacc gccagccatt gcaacggaat     3540

cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcc     3600

actgaggccc agctgcgcgc tcgctcgctc actgaggccg cccgggcaaa gcccgggcgt     3660

cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga gggagtggcc     3720

aactccatca ctaggggttc cttgtagtta atgattaacc cgccatgcta cttatctact     3780

cgacattgat tattgactag ttattaatag taatcaatta cggggtcatt agttcatagc     3840

ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc     3900

aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg     3960

actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat     4020

caagtgtatc atatgccaag tacgccccct attgacgtca atgacggtaa atggcccgcc     4080

tggcattatg cccagtacat gaccttatgg gactttccta cttggcagta catctacgta     4140

ttagtcatcg ctattaccat ggtcgaggtg agccccacgt tctgcttcac tctccccatc     4200

tcccccccct ccccaccccc aattttgtat ttatttattt tttaattatt ttgtgcagcg     4260

atgggggcgg gggggggggg ggggcgcgcg ccaggcgggg cggggcgggg cgaggggcgg     4320

ggcggggcga ggcggagagg tgcggcggca gccaatcaga gcggcgcgct ccgaaagttt     4380

ccttttatgg cgaggcggcg gcggcggcgg ccctataaaa agcgaagcgc gcggcgggcg     4440

ggagtcgctg cgttgccttc gccccgtgcc ccgctccgcg ccgcctcgcg ccgcccgccc     4500

cggctctgac tgaccgcgtt actcccacag gtgagcgggc gggacggccc ttctcctccg     4560

ggctgtaatt agcgcttggt ttaatgacgg cttgtttctt ttctgtggct gcgtgaaagc     4620

cttgaggggc tccgggaggg ccctttgtgc ggggggagcg gctcgggggg tgcgtgcgtg     4680

tgtgtgtgcg tggggagcgc cgcgtgcggc tccgcgctgc ccggcggctg tgagcgctgc     4740

gggcgcggcg cggggctttg tgcgctccgc agtgtgcgcg aggggagcgc ggccgggggc     4800

ggtgccccgc ggtgcggggg gctgcgaggg gaacaaaggc tgcgtgcggg gtgtgtgcgt     4860

gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc tgcacccccc     4920

tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg ggcgtggcgc     4980

ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg gggcggggcc     5040

gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg ccggcggctg     5100

tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga gggcgcaggg     5160

acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc gcaccccctc     5220

tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg gggagggcct     5280

tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct gtccgcgggg     5340

ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc gtgtgaccgg     5400

cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac agctcctggg     5460

caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattgatta attcgagcga     5520

acgcgtcgag tcgctcggta cgatttaaat tgaattggcc tcgagcgcaa gcttgagcta     5580

gcgccaccat ggaatggatg agaagcagag tgggcaccct gggcctgtgg gtgcgactgc     5640

tgctggctgt gtttctgctg ggcgtgtacc aggcctaccc catccctgac tctagccccc     5700

tgctgcagtt tggcggacaa gtgcggcaga gatacctgta caccgacgac gaccaggaca     5760

ccgaggccca cctggaaatc cgcgaggatg gcacagtcgt gggcgctgct cacagaagcc     5820

ctgagagcct gctggaactg aaggccctga agcccggcgt gatccagatc ctgggcgtga     5880

aggccagcag attcctgtgc cagcagcctg acggcgccct gtacggctct cctcacttcg     5940

atcctgaggc ctgcagcttc agagagctgc tgctggagga cggctacaac gtgtaccagt     6000

ctgaggccca cggcctgccc ctgagactgc ctcagaagga cagccctaac caggacgcca     6060

caagctgggg acctgtgcgg ttcctgccta tgcctggact gctgcacgag ccccaggatc     6120

aggctggctt tctgcctcct gagcctccag acgtgggcag cagcgaccct ctgagcatgg     6180

tggaacctct gcagggcaga agccccagct acgcctcttg agaatgcggg cccggtaccc     6240

ccgacgcggc ctaactggcc tcatgggcct tccgctcact gcccgctttc cagtcgggaa     6300

acctgtcgtg ccagtcaggt gcaggctgcc tatcagaagg tggtggctgg tgtggccaat     6360

gccctggctc acaaatacca ctgagatctt tttccctctg ccaaaaatta tggggacatc     6420

atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt cattgcaata     6480

gtgtgttgga attttttgtg tctctcactc ggaaggacat atgggagggc aaatcattta     6540

aaacatcaga atgagtattt ggtttagagt ttggcaacat atgcccatat gctggctgcc     6600

atgaacaaag gttggctata aagaggtcat cagtatatga aacagccccc tgctgtccat     6660

tccttattcc atagaaaagc cttgacttga ggttagattt tttttatatt ttgttttgtg     6720

ttattttttt ctttaacatc cctaaaattt tccttacatg ttttactagc cagatttttc     6780

ctcctctcct gactactccc agtcatagct gtccctcttc tcttatggag atccctcgac     6840

ctgcagccca agctgtagat aagtagcatg gcgggttaat cattaactac aaggaacccc     6900

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     6960

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     7020

gctggcgtaa                                                            7030


<210>  47
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  moFgf21-Fw

<400>  47
cctaaccagg acgccacaag                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  moFgf21-Rv

<400>  48
gttccaccat gctcagaggg                                                   20


<210>  49
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gfap-Fw

<400>  49
acagactttc tccaacctcc ag                                                22


<210>  50
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gfap-Rv

<400>  50
ccttctgaca cggatttggt                                                   20


<210>  51
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S100b-Fw

<400>  51
aacaacgagc tctctcactt cc                                                22


<210>  52
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  S100b-Rv

<400>  52
cgtctccatc actttgtcca                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Aif1-Fw

<400>  53
tgagccaaag cagggatttg                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Aif1-Rv

<400>  54
tcaagtttgg acggcagatc                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nfkb-Fw

<400>  55
gaccactgct caggtccact                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nfkb-Rv

<400>  56
tgtcactatc ccggagttca                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Il1b-Fw

<400>  57
atgaagggct gcttccaaac                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Il1b-Rv

<400>  58
atgtgctgct gcgagatttg                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Il6-Fw

<400>  59
tcgctcaggg tcacaagaaa                                                   20


<210>  60
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Il6-Rv

<400>  60
catcagaggc aaggaggaaa ac                                                22


<210>  61
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Ucp1-Fw

<400>  61
ggcctctacg actcagtcca                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Ucp1-Rv

<400>  62
taagccggct gagatcttgt                                                   20


<210>  63
<211>  5073
<212>  DNA
<213>  Artificial sequence

<220>
<223>  pAAV-CMV-moFGF21

<400>  63
ggggctagcg ccaccatgga atggatgaga agcagagtgg gcaccctggg cctgtgggtg       60

cgactgctgc tggctgtgtt tctgctgggc gtgtaccagg cctaccccat ccctgactct      120

agccccctgc tgcagtttgg cggacaagtg cggcagagat acctgtacac cgacgacgac      180

caggacaccg aggcccacct ggaaatccgc gaggatggca cagtcgtggg cgctgctcac      240

agaagccctg agagcctgct ggaactgaag gccctgaagc ccggcgtgat ccagatcctg      300

ggcgtgaagg ccagcagatt cctgtgccag cagcctgacg gcgccctgta cggctctcct      360

cacttcgatc ctgaggcctg cagcttcaga gagctgctgc tggaggacgg ctacaacgtg      420

taccagtctg aggcccacgg cctgcccctg agactgcctc agaaggacag ccctaaccag      480

gacgccacaa gctggggacc tgtgcggttc ctgcctatgc ctggactgct gcacgagccc      540

caggatcagg ctggctttct gcctcctgag cctccagacg tgggcagcag cgaccctctg      600

agcatggtgg aacctctgca gggcagaagc cccagctacg cctcttgaga atgcgggccc      660

ggtaccccct cgacggtacc agcgctgtcg aggccgcttc gagcagacat gataagatac      720

attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa      780

atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac      840

aacaattgca ttcattttat gtttcaggtt cagggggaga tgtgggaggt tttttaaagc      900

aagtaaaacc tctacaaatg tggtaaaatc gattaggatc ttcctagagc atggctacct      960

agacatggct cgacagatca gcgctcatgc tctggaagat ctcgatttaa atgcggccgc     1020

aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     1080

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc     1140

gagcgcgcag ctgcctgcag gggcgcctga tgcggtattt tctccttacg catctgtgcg     1200

gtatttcaca ccgcatacgt caaagcaacc atagtacgcg ccctgtagcg gcgcattaag     1260

cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc     1320

cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc     1380

tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa     1440

aaaacttgat ttgggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg     1500

ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac     1560

actcaaccct atctcgggct attcttttga tttataaggg attttgccga tttcggccta     1620

ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca aaatattaac     1680

gtttacaatt ttatggtgca ctctcagtac aatctgctct gatgccgcat agttaagcca     1740

gccccgacac ccgccaacac ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc     1800

cgcttacaga caagctgtga ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc     1860

atcaccgaaa cgcgcgagac gaaagggcct cgtgatacgc ctatttttat aggttaatgt     1920

catgataata atggtttctt agacgtcagg tggcactttt cggggaaatg tgcgcggaac     1980

ccctatttgt ttatttttct aaatacattc aaatatgtat ccgctcatga gacaataacc     2040

ctgataaatg cttcaataat attgaaaaag gaagagtatg agtattcaac atttccgtgt     2100

cgcccttatt cccttttttg cggcattttg ccttcctgtt tttgctcacc cagaaacgct     2160

ggtgaaagta aaagatgctg aagatcagtt gggtgcacga gtgggttaca tcgaactgga     2220

tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa gaacgttttc caatgatgag     2280

cacttttaaa gttctgctat gtggcgcggt attatcccgt attgacgccg ggcaagagca     2340

actcggtcgc cgcatacact attctcagaa tgacttggtt gagtactcac cagtcacaga     2400

aaagcatctt acggatggca tgacagtaag agaattatgc agtgctgcca taaccatgag     2460

tgataacact gcggccaact tacttctgac aacgatcgga ggaccgaagg agctaaccgc     2520

ttttttgcac aacatggggg atcatgtaac tcgccttgat cgttgggaac cggagctgaa     2580

tgaagccata ccaaacgacg agcgtgacac cacgatgcct gtagcaatgg caacaacgtt     2640

gcgcaaacta ttaactggcg aactacttac tctagcttcc cggcaacaat taatagactg     2700

gatggaggcg gataaagttg caggaccact tctgcgctcg gcccttccgg ctggctggtt     2760

tattgctgat aaatctggag ccggtgagcg tgggtctcgc ggtatcattg cagcactggg     2820

gccagatggt aagccctccc gtatcgtagt tatctacacg acggggagtc aggcaactat     2880

ggatgaacga aatagacaga tcgctgagat aggtgcctca ctgattaagc attggtaact     2940

gtcagaccaa gtttactcat atatacttta gattgattta aaacttcatt tttaatttaa     3000

aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt     3060

ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt     3120

ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg     3180

tttgccggat caagagctac caactctttt tccgaaggta actggcttca gcagagcgca     3240

gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca agaactctgt     3300

agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga     3360

taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc     3420

gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact     3480

gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga     3540

caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg     3600

aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt     3660

tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt     3720

acggttcctg gccttttgct ggccttttgc tcacatgtcc tgcaggcagc tgcgcgctcg     3780

ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc     3840

ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta ggggttcctg     3900

cggccgcgat atctgtagtt aatgattaac ccgccatgct acttatctac agatctcaat     3960

attggccatt agccatatta ttcattggtt atatagcata aatcaatatt ggctattggc     4020

cattgcatac gttgtatcta tatcataata tgtacattta tattggctca tgtccaatat     4080

gaccgccatg ttggcattga ttattgacta gttattaata gtaatcaatt acggggtcat     4140

tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat ggcccgcctg     4200

gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt cccatagtaa     4260

cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa actgcccact     4320

tggcagtaca tcaagtgtat catatgccaa gtccgccccc tattgacgtc aatgacggta     4380

aatggcccgc ctggcattat gcccagtaca tgaccttacg ggactttcct acttggcagt     4440

acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag tacaccaatg     4500

ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt gacgtcaatg     4560

ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac aactgcgatc     4620

gcccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg tgggaggtct atataagcag     4680

agctcgttta gtgaaccgtc agatcactag gctagctatt gcggtagttt atcacagtta     4740

aattgctaac gcagtcagtg cttctgacac aacagtctcg aacttaagct gcagtgactc     4800

tcttaaggta gccttgcaga agttggtcgt gaggcactgg gcaggtaagt atcaaggtta     4860

caagacaggt ttaaggagac caatagaaac tgggcttgtc gagacagaga agactcttgc     4920

gtttctgata ggcacctatt ggtcttactg acatccactt tgcctttctc tccacaggtg     4980

tccactccca gttcaattac agctcttaag gctagagtac ttaatacgac tcactataga     5040

atacgactca ctatagggag acgctagcgt cga                                  5073


<210>  64
<211>  397
<212>  DNA
<213>  Artificial sequence

<220>
<223>  hAAT promoter

<400>  64
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agtgaat                               397


<210>  65
<211>  154
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Hepatocyte control region (HCR) enhancer from apolipoprotein E

<400>  65
cagagaggtc tctgacctct gccccagctc caaggtcagc aggcagggag ggctgtgtgt       60

ttgctgtttg ctgcttgcaa tgtttgccca ttttagggac atgagtaggc tgaagtttgt      120

tcagtgtgga cttcagaggc agcacacaaa cagc                                  154


<210>  66
<211>  651
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mini/aP2 promoter

<400>  66
gattaacccg ccatgctact tatctactcg acattgatta ttgactaggg gaattccagc       60

aggaatcagg tagctggaga atcgcacaga gccatgcgat tcttggcaag ccatgcgaca      120

aaggcagaaa tgcacatttc acccagagag aagggattga tgtcagcagg aagtcaccac      180

ccagagagca aatggagttc ccagatgcct gacatttgcc ttcttactgg atcagagttc      240

actagtggaa gtgtcacagc ccaaacactc ccccaaagct cagcccttcc ttgccttgta      300

acaatcaagc cgctcctgga tgaactgctc cgccctctgt ctctttggca gggttggagc      360

ccactgtggc ctgagcgact tctatggctc ccttttctgt gattttcatg gtttctgagc      420

tcttttcccc cgctttatga ttttctcttt ttgtctctct cttgctaaac ctccttcgta      480

tatatgccct ctcaggtttc atttctgaat catctactgt gaactattcc cattgtttgc      540

cagaagcccc ctggttcttc cttctagaca ccaggcaagg ggcaggaggt aagaggcagg      600

agtccataaa acagccctga gagcctgctg ggtcagtgcc tgctgtcaga a               651


<210>  67
<211>  722
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mini/UCP1

<400>  67
gacgtcacag tgggtcagtc acccttgatc acactgcacc agtcttcacc tttccacgct       60

tcctgccaga gcatgaatca ggctctctgg ggataccggc ctcaccccta ctgaggcaaa      120

ctttctccca cttctcagag gctctgaggg cagcaaggtc agccctttct ttggaatcta      180

gaaccactcc ctgtcttgag ctgacatcac agggcaggca gatgcagcag ggaagggcct      240

gggactggga cgttcatcct acaagaaagc tgtggaactt ttcagcaaca tctcagaaat      300

cagatcgcac ttattcaaag gagccaggcc ctgctctgcg ccctggtgga ggctcctcat      360

gtgaagagtg acaaaaggca ccatgttgtg gatacggggc gaagcccctc cggtgtgtcc      420

tccaggcatc atcaggaact agtgccaaag cagaggtgct ggccagggct ttgggagtga      480

cgcgcgtctg ggaggcttgt gcgcccaggg cacgcccctg ccgattccca ctagcaggtc      540

ttgggggacc tgggccggct ctgcccctcc tccagcaatc gggctataaa gctcttccaa      600

gtcagggcgc agaagtgccg ggcgatccgg gcttaaagag cgagaggaag ggacgctcac      660

ctttgagctc ctccacaaat agccctggtg gctgccacag aagttcgaag ttgagagttc      720

gg                                                                     722


<210>  68
<211>  326
<212>  DNA
<213>  Artificial sequence

<220>
<223>  C5-12 promoter

<400>  68
cggccgtccg ccttcggcac catcctcacg acacccaaat atggcgacgg gtgaggaatg       60

gtggggagtt atttttagag cggtgaggaa ggtgggcagg cagcaggtgt tggcgctcta      120

aaaataactc ccgggagtta tttttagagc ggaggaatgg tggacaccca aatatggcga      180

cggttcctca cccgtcgcca tatttgggtg tccgccctcg gccggggccg cattcctggg      240

ggccgggcgg tgctcccgcc cgcctcgata aaaggctccg gggccggcgg cggcccacga      300

gctacccgga ggagcgggag gcgcca                                           326


<210>  69
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Ccl19-Fw

<400>  69
gcgggctcac tggggcacac                                                   20


<210>  70
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Ccl19-Rv

<400>  70
tgggaaggtc cagagaacca g                                                 21


<210>  71
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Ppargc1a-Fw

<400>  71
tttggccgac gacacgactt ttc                                               23


<210>  72
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Ppargc1a-Rv

<400>  72
ttgtgttggg cgagagaaag                                                   20


<210>  73
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Ppargc1b-Fw

<400>  73
agaagcgctt tgaggtgttc                                                   20


<210>  74
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Ppargc1b-Rv

<400>  74
ggtgataaaa ccgtgcttct gg                                                22


<210>  75
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Atp5f1a-Fw

<400>  75
tctcggccag agactaggac                                                   20


<210>  76
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Atp5f1a-Rv

<400>  76
gcacttgcac caatgaattt                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mt-co1-Fw

<400>  77
atgagcaaaa gcccacttcg                                                   20


<210>  78
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Mt-co1-Rv

<400>  78
accgtggaga tttggtccag                                                   20


<210>  79
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cox6-Fw

<400>  79
agtccctctg tcccgtgtc                                                    19


<210>  80
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cox6-Rv

<400>  80
atatgctgag gtcccccttt                                                   20


<210>  81
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cox5a-Fw

<400>  81
ctcgtcagcc tcagccagt                                                    19


<210>  82
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cox5a-Rv

<400>  82
tagcagcgaa tggaacagac                                                   20


<210>  83
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sod1-Fw

<400>  83
tacacaaggc tgtaccagtg c                                                 21


<210>  84
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sod1-Rv

<400>  84
tttccagcag tcacattgcc                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nrf2-Fw

<400>  85
agtcgcttgc cctggatatc                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nrf2-Rv

<400>  86
tgccaaactt gctccatgtc                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cat-Fw

<400>  87
tgtgcatgca tgacaaccag                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cat-Rv

<400>  88
gcactgttga agcgtttcac                                                   20


<210>  89
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gapdh-Fw

<400>  89
ccttccgtgt tcctaccc                                                     18


<210>  90
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gapdh-Rv

<400>  90
caacctggtc ctcactgtag                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HkI-Fw

<400>  91
acggtcaaaa tgctgccttc                                                   20


<210>  92
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  HkI-Rv

<400>  92
aatcgttcct ccgagatcca                                                   20


<210>  93
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfkp-Fw

<400>  93
tgtgtctgaa ggagcaatcg                                                   20


<210>  94
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pfkp-Rv

<400>  94
ggccaaaatc ctgtcaaatg                                                   20


<210>  95
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gpd1-Fw

<400>  95
agacacccaa ctttcgcatc                                                   20


<210>  96
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gpd1-Rv

<400>  96
tattcttcaa ggccccacag                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gpd2-Fw

<400>  97
ttgccttggg agaagatgac                                                   20


<210>  98
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gpd2-Rv

<400>  98
agttccgcac ttcattcagg                                                   20


<210>  99
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pkm-Fw

<400>  99
gctttgcatc tgatcccatt                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Pkm-Rv

<400>  100
agtccagcca caggatgttc                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Syp-Fw

<400>  101
acatggacgt ggtgaatcag                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Syp-Rv

<400>  102
aagatggcaa agacccactg                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gria1-Fw

<400>  103
ccatgctggt tgccttaatc                                                   20


<210>  104
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gria1-Rv

<400>  104
ccgtatggct tcattgatgg                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gria2-Fw

<400>  105
aagggcgtgt aatccttgac                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Gria2-Rv

<400>  106
tttcagcagg tctccatcag                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Grin1-Fw

<400>  107
tgactacccg aatgtccatc                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Grin1-Rv

<400>  108
ttgtagacgc gcatcatctc                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Grin2a-Fw

<400>  109
tgtgaagaag tgctgcaagg                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Grin2a-Rv

<400>  110
cgcctatcat tccattccac                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Grin2b-Fw

<400>  111
ttggtgaggt ggtcatgaag                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Grin2b-Rv

<400>  112
tgcgtgatac catgacactg                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sqstm1-Fw

<400>  113
tgctggcggc tttacatttg                                                   20


<210>  114
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sqstm1-Rv

<400>  114
cagaagcaga gaaggaaaag cc                                                22


<210>  115
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Atg5-Fw

<400>  115
agatggacag ctgcacacac                                                   20


<210>  116
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Atg5-Rv

<400>  116
ttggctctat cccgtgaatc                                                   20


<210>  117
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Atf4-Fw

<400>  117
atgatggctt ggccagtg                                                     18


<210>  118
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Atf4-Rv

<400>  118
ccattttctc caacatccaa tc                                                22


<210>  119
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bip-Fw

<400>  119
ctgaggcgta ttgggaag                                                     18


<210>  120
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Bip-Rv

<400>  120
tcatgacatt cagtccagca a                                                 21


<210>  121
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cyp46a1-Fw

<400>  121
tcgttgaacg tctccatcag                                                   20


<210>  122
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cyp46a1-Rv

<400>  122
tttggggaga gactgtttgg                                                   20


