                         SEQUENCE LISTING

<110>  Helmholtz Zentrum Muenchen GmbH
 
<120>  Axial stem cells, methods of producing and uses thereof

<130>  HEL16988PCT

<150>  EP20176375
<151>  2020-05-25

<150>  LU101823
<151>  2020-05-27

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH, forward primer

<400>  1
cgctctctgc tcctcctgtt                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAPDH, reverse primer

<400>  2
ccatggtgtc tgagcgatgt                                                   20


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MNX1, forward primer

<400>  3
gctcaacaag tacctgtcg                                                    19


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MNX1, reverse primer

<400>  4
caaatcttca cctgggtctc                                                   20


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRPH, forward primer

<400>  5
tacaagtcca agtacgcgg                                                    19


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRPH, reverse primer

<400>  6
tcgttcatct cctgcttgg                                                    19


<210>  7
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  POU4F1, forward primer

<400>  7
ctccctgagc acaagtacc                                                    19


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  POU4F1, reverse primer

<400>  8
ttgaaaggat ggctcttgc                                                    19


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RUNX2, forward primer

<400>  9
accttgacca taaccgtctt c                                                 21


<210>  10
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RUNX2, reverse primer

<400>  10
gcttctgtct gtgccttct                                                    19


<210>  11
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGLAP, forward primer

<400>  11
ctttgtgtcc aagcaggag                                                    19


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGLAP, reverse primer

<400>  12
ctcccagcca ttgatacag                                                    19


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL1A1, forward primer

<400>  13
ctggaagagt ggagagtact g                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL1A1, reverse primer

<400>  14
gtctccatgt tgcagaagac                                                   20


<210>  15
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NKX3-2, forward primer

<400>  15
ccagagacaa tacctgccc                                                    19


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NKX3-2, reverse primer

<400>  16
aatagtagga gggctgcag                                                    19


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COMP, forward primer

<400>  17
caagaccagg atggagacg                                                    19


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COMP, reverse primer

<400>  18
caagaccagg atggagacg                                                    19


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACAN, forward primer

<400>  19
ctgaccagac tgtcagatac c                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACAN, reverse primer

<400>  20
ctgaccagac tgtcagatac c                                                 21


<210>  21
<211>  317
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(317)
<223>  SOX-2, UniProtKB Accession Number: P48431

<400>  21

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  22
<211>  360
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(360)
<223>  POU5F1/OCT4, UniProtKB Accession Number: Q01860-1

<400>  22

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  23
<211>  305
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(305)
<223>  NANOG, UniProtKB Accession Number: Q9H9S0-1

<400>  23

Met Ser Val Asp Pro Ala Cys Pro Gln Ser Leu Pro Cys Phe Glu Ala 
1               5                   10                  15      


Ser Asp Cys Lys Glu Ser Ser Pro Met Pro Val Ile Cys Gly Pro Glu 
            20                  25                  30          


Glu Asn Tyr Pro Ser Leu Gln Met Ser Ser Ala Glu Met Pro His Thr 
        35                  40                  45              


Glu Thr Val Ser Pro Leu Pro Ser Ser Met Asp Leu Leu Ile Gln Asp 
    50                  55                  60                  


Ser Pro Asp Ser Ser Thr Ser Pro Lys Gly Lys Gln Pro Thr Ser Ala 
65                  70                  75                  80  


Glu Lys Ser Val Ala Lys Lys Glu Asp Lys Val Pro Val Lys Lys Gln 
                85                  90                  95      


Lys Thr Arg Thr Val Phe Ser Ser Thr Gln Leu Cys Val Leu Asn Asp 
            100                 105                 110         


Arg Phe Gln Arg Gln Lys Tyr Leu Ser Leu Gln Gln Met Gln Glu Leu 
        115                 120                 125             


Ser Asn Ile Leu Asn Leu Ser Tyr Lys Gln Val Lys Thr Trp Phe Gln 
    130                 135                 140                 


Asn Gln Arg Met Lys Ser Lys Arg Trp Gln Lys Asn Asn Trp Pro Lys 
145                 150                 155                 160 


Asn Ser Asn Gly Val Thr Gln Lys Ala Ser Ala Pro Thr Tyr Pro Ser 
                165                 170                 175     


Leu Tyr Ser Ser Tyr His Gln Gly Cys Leu Val Asn Pro Thr Gly Asn 
            180                 185                 190         


Leu Pro Met Trp Ser Asn Gln Thr Trp Asn Asn Ser Thr Trp Ser Asn 
        195                 200                 205             


Gln Thr Gln Asn Ile Gln Ser Trp Ser Asn His Ser Trp Asn Thr Gln 
    210                 215                 220                 


Thr Trp Cys Thr Gln Ser Trp Asn Asn Gln Ala Trp Asn Ser Pro Phe 
225                 230                 235                 240 


Tyr Asn Cys Gly Glu Glu Ser Leu Gln Ser Cys Met Gln Phe Gln Pro 
                245                 250                 255     


Asn Ser Pro Ala Ser Asp Leu Glu Ala Ala Leu Glu Ala Ala Gly Glu 
            260                 265                 270         


Gly Leu Asn Val Ile Gln Gln Thr Thr Arg Tyr Phe Ser Thr Pro Gln 
        275                 280                 285             


Thr Met Asp Leu Phe Leu Asn Tyr Ser Met Asn Met Gln Pro Glu Asp 
    290                 295                 300                 


Val 
305 


<210>  24
<211>  435
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(435)
<223>  TBXT, UniProtKB Accession Number: O15178-1

<400>  24

Met Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys Ser Leu Gln Tyr Arg 
1               5                   10                  15      


Val Asp His Leu Leu Ser Ala Val Glu Asn Glu Leu Gln Ala Gly Ser 
            20                  25                  30          


Glu Lys Gly Asp Pro Thr Glu Arg Glu Leu Arg Val Gly Leu Glu Glu 
        35                  40                  45              


Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr Asn Glu Met Ile Val 
    50                  55                  60                  


Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu Lys Val Asn Val Ser 
65                  70                  75                  80  


Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu Leu Asp Phe Val Ala 
                85                  90                  95      


Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly Glu Trp Val Pro Gly 
            100                 105                 110         


Gly Lys Pro Glu Pro Gln Ala Pro Ser Cys Val Tyr Ile His Pro Asp 
        115                 120                 125             


Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala Pro Val Ser Phe Ser 
    130                 135                 140                 


Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly Gly Gln Ile Met Leu 
145                 150                 155                 160 


Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His Ile Val Arg Val Gly 
                165                 170                 175     


Gly Pro Gln Arg Met Ile Thr Ser His Cys Phe Pro Glu Thr Gln Phe 
            180                 185                 190         


Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile Thr Ala Leu Lys Ile 
        195                 200                 205             


Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp Ala Lys Glu Arg Ser 
    210                 215                 220                 


Asp His Lys Glu Met Met Glu Glu Pro Gly Asp Ser Gln Gln Pro Gly 
225                 230                 235                 240 


Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr Ser Thr Leu Cys Pro 
                245                 250                 255     


Pro Ala Asn Pro His Pro Gln Phe Gly Gly Ala Leu Ser Leu Pro Ser 
            260                 265                 270         


Thr His Ser Cys Asp Arg Tyr Pro Thr Leu Arg Ser His Arg Ser Ser 
        275                 280                 285             


Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn Ser Pro Thr Tyr Ser 
    290                 295                 300                 


Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln Ser His Asp Asn Trp 
305                 310                 315                 320 


Ser Ser Leu Gly Met Pro Ala His Pro Ser Met Leu Pro Val Ser His 
                325                 330                 335     


Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr Pro Ser Leu Trp Ser 
            340                 345                 350         


Val Ser Asn Gly Ala Val Thr Pro Gly Ser Gln Ala Ala Ala Val Ser 
        355                 360                 365             


Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser Pro Ala His Tyr Thr 
    370                 375                 380                 


Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser Ser Gly Ser Pro Leu 
385                 390                 395                 400 


Tyr Glu Gly Ala Ala Ala Ala Thr Asp Ile Val Asp Ser Gln Tyr Asp 
                405                 410                 415     


Ala Ala Ala Gln Gly Arg Leu Ile Ala Ser Trp Thr Pro Val Ser Pro 
            420                 425                 430         


Pro Ser Met 
        435 


<210>  25
<211>  313
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(313)
<223>  CDX2, UniProtKB Accession Number: Q99626-1

<400>  25

Met Tyr Val Ser Tyr Leu Leu Asp Lys Asp Val Ser Met Tyr Pro Ser 
1               5                   10                  15      


Ser Val Arg His Ser Gly Gly Leu Asn Leu Ala Pro Gln Asn Phe Val 
            20                  25                  30          


Ser Pro Pro Gln Tyr Pro Asp Tyr Gly Gly Tyr His Val Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Asn Leu Asp Ser Ala Gln Ser Pro Gly Pro Ser 
    50                  55                  60                  


Trp Pro Ala Ala Tyr Gly Ala Pro Leu Arg Glu Asp Trp Asn Gly Tyr 
65                  70                  75                  80  


Ala Pro Gly Gly Ala Ala Ala Ala Ala Asn Ala Val Ala His Gly Leu 
                85                  90                  95      


Asn Gly Gly Ser Pro Ala Ala Ala Met Gly Tyr Ser Ser Pro Ala Asp 
            100                 105                 110         


Tyr His Pro His His His Pro His His His Pro His His Pro Ala Ala 
        115                 120                 125             


Ala Pro Ser Cys Ala Ser Gly Leu Leu Gln Thr Leu Asn Pro Gly Pro 
    130                 135                 140                 


Pro Gly Pro Ala Ala Thr Ala Ala Ala Glu Gln Leu Ser Pro Gly Gly 
145                 150                 155                 160 


Gln Arg Arg Asn Leu Cys Glu Trp Met Arg Lys Pro Ala Gln Gln Ser 
                165                 170                 175     


Leu Gly Ser Gln Val Lys Thr Arg Thr Lys Asp Lys Tyr Arg Val Val 
            180                 185                 190         


Tyr Thr Asp His Gln Arg Leu Glu Leu Glu Lys Glu Phe His Tyr Ser 
        195                 200                 205             


Arg Tyr Ile Thr Ile Arg Arg Lys Ala Glu Leu Ala Ala Thr Leu Gly 
    210                 215                 220                 


Leu Ser Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ala Lys 
225                 230                 235                 240 


Glu Arg Lys Ile Asn Lys Lys Lys Leu Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Pro Pro Gln Pro Pro Pro Pro Pro Pro Gln Pro Pro Gln Pro Gln Pro 
            260                 265                 270         


Gly Pro Leu Arg Ser Val Pro Glu Pro Leu Ser Pro Val Ser Ser Leu 
        275                 280                 285             


Gln Ala Ser Val Pro Gly Ser Val Pro Gly Val Leu Gly Pro Thr Gly 
    290                 295                 300                 


Gly Val Leu Asn Pro Thr Val Thr Gln 
305                 310             


<210>  26
<211>  232
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(232)
<223>  MIXL1, UniProtKB Accession Number: Q9H2W2-1

<400>  26

Met Ala Thr Ala Glu Ser Arg Ala Leu Gln Phe Ala Glu Gly Ala Ala 
1               5                   10                  15      


Phe Pro Ala Tyr Arg Ala Pro His Ala Gly Gly Ala Leu Leu Pro Pro 
            20                  25                  30          


Pro Ser Pro Ala Ala Ala Leu Leu Pro Ala Pro Pro Ala Gly Pro Gly 
        35                  40                  45              


Pro Ala Thr Phe Ala Gly Phe Leu Gly Arg Asp Pro Gly Pro Ala Pro 
    50                  55                  60                  


Pro Pro Pro Ala Ser Leu Gly Ser Pro Ala Pro Pro Lys Gly Ala Ala 
65                  70                  75                  80  


Ala Pro Ser Ala Ser Gln Arg Arg Lys Arg Thr Ser Phe Ser Ala Glu 
                85                  90                  95      


Gln Leu Gln Leu Leu Glu Leu Val Phe Arg Arg Thr Arg Tyr Pro Asp 
            100                 105                 110         


Ile His Leu Arg Glu Arg Leu Ala Ala Leu Thr Leu Leu Pro Glu Ser 
        115                 120                 125             


Arg Ile Gln Val Trp Phe Gln Asn Arg Arg Ala Lys Ser Arg Arg Gln 
    130                 135                 140                 


Ser Gly Lys Ser Phe Gln Pro Leu Ala Arg Pro Glu Ile Ile Leu Asn 
145                 150                 155                 160 


His Cys Ala Pro Gly Thr Glu Thr Lys Cys Leu Lys Pro Gln Leu Pro 
                165                 170                 175     


Leu Glu Val Asp Val Asn Cys Leu Pro Glu Pro Asn Gly Val Gly Gly 
            180                 185                 190         


Gly Ile Ser Asp Ser Ser Ser Gln Gly Gln Asn Phe Glu Thr Cys Ser 
        195                 200                 205             


Pro Leu Ser Glu Asp Ile Gly Ser Lys Leu Asp Ser Trp Glu Glu His 
    210                 215                 220                 


Ile Phe Ser Ala Phe Gly Asn Phe 
225                 230         


<210>  27
<211>  422
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(422)
<223>  PAX6, UniProtKB Accession Number: P26367-1

<400>  27

Met Gln Asn Ser His Ser Gly Val Asn Gln Leu Gly Gly Val Phe Val 
1               5                   10                  15      


Asn Gly Arg Pro Leu Pro Asp Ser Thr Arg Gln Lys Ile Val Glu Leu 
            20                  25                  30          


Ala His Ser Gly Ala Arg Pro Cys Asp Ile Ser Arg Ile Leu Gln Val 
        35                  40                  45              


Ser Asn Gly Cys Val Ser Lys Ile Leu Gly Arg Tyr Tyr Glu Thr Gly 
    50                  55                  60                  


Ser Ile Arg Pro Arg Ala Ile Gly Gly Ser Lys Pro Arg Val Ala Thr 
65                  70                  75                  80  


Pro Glu Val Val Ser Lys Ile Ala Gln Tyr Lys Arg Glu Cys Pro Ser 
                85                  90                  95      


Ile Phe Ala Trp Glu Ile Arg Asp Arg Leu Leu Ser Glu Gly Val Cys 
            100                 105                 110         


Thr Asn Asp Asn Ile Pro Ser Val Ser Ser Ile Asn Arg Val Leu Arg 
        115                 120                 125             


Asn Leu Ala Ser Glu Lys Gln Gln Met Gly Ala Asp Gly Met Tyr Asp 
    130                 135                 140                 


Lys Leu Arg Met Leu Asn Gly Gln Thr Gly Ser Trp Gly Thr Arg Pro 
145                 150                 155                 160 


Gly Trp Tyr Pro Gly Thr Ser Val Pro Gly Gln Pro Thr Gln Asp Gly 
                165                 170                 175     


Cys Gln Gln Gln Glu Gly Gly Gly Glu Asn Thr Asn Ser Ile Ser Ser 
            180                 185                 190         


Asn Gly Glu Asp Ser Asp Glu Ala Gln Met Arg Leu Gln Leu Lys Arg 
        195                 200                 205             


Lys Leu Gln Arg Asn Arg Thr Ser Phe Thr Gln Glu Gln Ile Glu Ala 
    210                 215                 220                 


Leu Glu Lys Glu Phe Glu Arg Thr His Tyr Pro Asp Val Phe Ala Arg 
225                 230                 235                 240 


Glu Arg Leu Ala Ala Lys Ile Asp Leu Pro Glu Ala Arg Ile Gln Val 
                245                 250                 255     


Trp Phe Ser Asn Arg Arg Ala Lys Trp Arg Arg Glu Glu Lys Leu Arg 
            260                 265                 270         


Asn Gln Arg Arg Gln Ala Ser Asn Thr Pro Ser His Ile Pro Ile Ser 
        275                 280                 285             


Ser Ser Phe Ser Thr Ser Val Tyr Gln Pro Ile Pro Gln Pro Thr Thr 
    290                 295                 300                 


Pro Val Ser Ser Phe Thr Ser Gly Ser Met Leu Gly Arg Thr Asp Thr 
305                 310                 315                 320 


Ala Leu Thr Asn Thr Tyr Ser Ala Leu Pro Pro Met Pro Ser Phe Thr 
                325                 330                 335     


Met Ala Asn Asn Leu Pro Met Gln Pro Pro Val Pro Ser Gln Thr Ser 
            340                 345                 350         


Ser Tyr Ser Cys Met Leu Pro Thr Ser Pro Ser Val Asn Gly Arg Ser 
        355                 360                 365             


Tyr Asp Thr Tyr Thr Pro Pro His Met Gln Thr His Met Asn Ser Gln 
    370                 375                 380                 


Pro Met Gly Thr Ser Gly Thr Thr Ser Thr Gly Leu Ile Ser Pro Gly 
385                 390                 395                 400 


Val Ser Val Pro Val Gln Val Pro Gly Ser Glu Pro Asp Met Ser Gln 
                405                 410                 415     


Tyr Trp Pro Arg Leu Gln 
            420         


<210>  28
<211>  420
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(420)
<223>  GSK3B, UniProtKB Accession Number: P49841-1

<400>  28

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val 
    290                 295                 300                 


Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu 
305                 310                 315                 320 


Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala 
                325                 330                 335     


His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn 
            340                 345                 350         


Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser 
        355                 360                 365             


Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile 
    370                 375                 380                 


Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Asn Thr Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala 
                405                 410                 415     


Ser Asn Ser Thr 
            420 


<210>  29
<211>  288
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(288)
<223>  FGF2, UniProtKB Accession Number: P09038-4

<400>  29

Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210>  30
<211>  390
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(390)
<223>  TGFB1, UniProtKB Accession Number: P01137-1

<400>  30

Met Pro Pro Ser Gly Leu Arg Leu Leu Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210>  31
<211>  250
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(250)
<223>  LIN28B, UniProtKB Accession Number: Q6ZN17-1

<400>  31

Met Ala Glu Gly Gly Ala Ser Lys Gly Gly Gly Glu Glu Pro Gly Lys 
1               5                   10                  15      


Leu Pro Glu Pro Ala Glu Glu Glu Ser Gln Val Leu Arg Gly Thr Gly 
            20                  25                  30          


His Cys Lys Trp Phe Asn Val Arg Met Gly Phe Gly Phe Ile Ser Met 
        35                  40                  45              


Ile Asn Arg Glu Gly Ser Pro Leu Asp Ile Pro Val Asp Val Phe Val 
    50                  55                  60                  


His Gln Ser Lys Leu Phe Met Glu Gly Phe Arg Ser Leu Lys Glu Gly 
65                  70                  75                  80  


Glu Pro Val Glu Phe Thr Phe Lys Lys Ser Ser Lys Gly Leu Glu Ser 
                85                  90                  95      


Ile Arg Val Thr Gly Pro Gly Gly Ser Pro Cys Leu Gly Ser Glu Arg 
            100                 105                 110         


Arg Pro Lys Gly Lys Thr Leu Gln Lys Arg Lys Pro Lys Gly Asp Arg 
        115                 120                 125             


Cys Tyr Asn Cys Gly Gly Leu Asp His His Ala Lys Glu Cys Ser Leu 
    130                 135                 140                 


Pro Pro Gln Pro Lys Lys Cys His Tyr Cys Gln Ser Ile Met His Met 
145                 150                 155                 160 


Val Ala Asn Cys Pro His Lys Asn Val Ala Gln Pro Pro Ala Ser Ser 
                165                 170                 175     


Gln Gly Arg Gln Glu Ala Glu Ser Gln Pro Cys Thr Ser Thr Leu Pro 
            180                 185                 190         


Arg Glu Val Gly Gly Gly His Gly Cys Thr Ser Pro Pro Phe Pro Gln 
        195                 200                 205             


Glu Ala Arg Ala Glu Ile Ser Glu Arg Ser Gly Arg Ser Pro Gln Glu 
    210                 215                 220                 


Ala Ser Ser Thr Lys Ser Ser Ile Ala Pro Glu Glu Gln Ser Lys Lys 
225                 230                 235                 240 


Gly Pro Ser Val Gln Lys Arg Lys Lys Thr 
                245                 250 


<210>  32
<211>  464
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(464)
<223>  MYCN, UniProtKB Accession Number: P04198-1

<400>  32

Met Pro Ser Cys Ser Thr Ser Thr Met Pro Gly Met Ile Cys Lys Asn 
1               5                   10                  15      


Pro Asp Leu Glu Phe Asp Ser Leu Gln Pro Cys Phe Tyr Pro Asp Glu 
            20                  25                  30          


Asp Asp Phe Tyr Phe Gly Gly Pro Asp Ser Thr Pro Pro Gly Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Gly Phe Ala Glu His Ser Ser Glu Pro Pro Ser Trp Val Thr Glu 
65                  70                  75                  80  


Met Leu Leu Glu Asn Glu Leu Trp Gly Ser Pro Ala Glu Glu Asp Ala 
                85                  90                  95      


Phe Gly Leu Gly Gly Leu Gly Gly Leu Thr Pro Asn Pro Val Ile Leu 
            100                 105                 110         


Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Lys Leu Glu Arg 
        115                 120                 125             


Ala Val Ser Glu Lys Leu Gln His Gly Arg Gly Pro Pro Thr Ala Gly 
    130                 135                 140                 


Ser Thr Ala Gln Ser Pro Gly Ala Gly Ala Ala Ser Pro Ala Gly Arg 
145                 150                 155                 160 


Gly His Gly Gly Ala Ala Gly Ala Gly Arg Ala Gly Ala Ala Leu Pro 
                165                 170                 175     


Ala Glu Leu Ala His Pro Ala Ala Glu Cys Val Asp Pro Ala Val Val 
            180                 185                 190         


Phe Pro Phe Pro Val Asn Lys Arg Glu Pro Ala Pro Val Pro Ala Ala 
        195                 200                 205             


Pro Ala Ser Ala Pro Ala Ala Gly Pro Ala Val Ala Ser Gly Ala Gly 
    210                 215                 220                 


Ile Ala Ala Pro Ala Gly Ala Pro Gly Val Ala Pro Pro Arg Pro Gly 
225                 230                 235                 240 


Gly Arg Gln Thr Ser Gly Gly Asp His Lys Ala Leu Ser Thr Ser Gly 
                245                 250                 255     


Glu Asp Thr Leu Ser Asp Ser Asp Asp Glu Asp Asp Glu Glu Glu Asp 
            260                 265                 270         


Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser 
        275                 280                 285             


Ser Asn Thr Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys 
    290                 295                 300                 


Asn Ala Ala Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Cys Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser 
                325                 330                 335     


Pro Tyr Val Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser 
            340                 345                 350         


Glu Ala Ser Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys 
        355                 360                 365             


Ser Leu Ser Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg 
    370                 375                 380                 


Asn His Asn Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser 
385                 390                 395                 400 


Phe Leu Thr Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys 
                405                 410                 415     


Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser 
            420                 425                 430         


Leu Gln Ala Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln 
        435                 440                 445             


Ala Arg Gln Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys 
    450                 455                 460                 


<210>  33
<211>  532
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(532)
<223>  ZIC2, UniProtKB Accession Number: O95409-1

<400>  33

Met Leu Leu Asp Ala Gly Pro Gln Phe Pro Ala Ile Gly Val Gly Ser 
1               5                   10                  15      


Phe Ala Arg His His His His Ser Ala Ala Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Glu Met Gln Asp Arg Glu Leu Ser Leu Ala Ala Ala Gln Asn Gly 
        35                  40                  45              


Phe Val Asp Ser Ala Ala Ala His Met Gly Ala Phe Lys Leu Asn Pro 
    50                  55                  60                  


Gly Ala His Glu Leu Ser Pro Gly Gln Ser Ser Ala Phe Thr Ser Gln 
65                  70                  75                  80  


Gly Pro Gly Ala Tyr Pro Gly Ser Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Ala Leu Gly Pro His Ala Ala His Val Gly Ser Tyr Ser Gly Pro Pro 
            100                 105                 110         


Phe Asn Ser Thr Arg Asp Phe Leu Phe Arg Ser Arg Gly Phe Gly Asp 
        115                 120                 125             


Ser Ala Pro Gly Gly Gly Gln His Gly Leu Phe Gly Pro Gly Ala Gly 
    130                 135                 140                 


Gly Leu His His Ala His Ser Asp Ala Gln Gly His Leu Leu Phe Pro 
145                 150                 155                 160 


Gly Leu Pro Glu Gln His Gly Pro His Gly Ser Gln Asn Val Leu Asn 
                165                 170                 175     


Gly Gln Met Arg Leu Gly Leu Pro Gly Glu Val Phe Gly Arg Ser Glu 
            180                 185                 190         


Gln Tyr Arg Gln Val Ala Ser Pro Arg Thr Asp Pro Tyr Ser Ala Ala 
        195                 200                 205             


Gln Leu His Asn Gln Tyr Gly Pro Met Asn Met Asn Met Gly Met Asn 
    210                 215                 220                 


Met Ala Ala Ala Ala Ala His His His His His His His His His Pro 
225                 230                 235                 240 


Gly Ala Phe Phe Arg Tyr Met Arg Gln Gln Cys Ile Lys Gln Glu Leu 
                245                 250                 255     


Ile Cys Lys Trp Ile Asp Pro Glu Gln Leu Ser Asn Pro Lys Lys Ser 
            260                 265                 270         


Cys Asn Lys Thr Phe Ser Thr Met His Glu Leu Val Thr His Val Ser 
        275                 280                 285             


Val Glu His Val Gly Gly Pro Glu Gln Ser Asn His Val Cys Phe Trp 
    290                 295                 300                 


Glu Glu Cys Pro Arg Glu Gly Lys Pro Phe Lys Ala Lys Tyr Lys Leu 
305                 310                 315                 320 


Val Asn His Ile Arg Val His Thr Gly Glu Lys Pro Phe Pro Cys Pro 
                325                 330                 335     


Phe Pro Gly Cys Gly Lys Val Phe Ala Arg Ser Glu Asn Leu Lys Ile 
            340                 345                 350         


His Lys Arg Thr His Thr Gly Glu Lys Pro Phe Gln Cys Glu Phe Glu 
        355                 360                 365             


Gly Cys Asp Arg Arg Phe Ala Asn Ser Ser Asp Arg Lys Lys His Met 
    370                 375                 380                 


His Val His Thr Ser Asp Lys Pro Tyr Leu Cys Lys Met Cys Asp Lys 
385                 390                 395                 400 


Ser Tyr Thr His Pro Ser Ser Leu Arg Lys His Met Lys Val His Glu 
                405                 410                 415     


Ser Ser Pro Gln Gly Ser Glu Ser Ser Pro Ala Ala Ser Ser Gly Tyr 
            420                 425                 430         


Glu Ser Ser Thr Pro Pro Gly Leu Val Ser Pro Ser Ala Glu Pro Gln 
        435                 440                 445             


Ser Ser Ser Asn Leu Ser Pro Ala Ala Ala Ala Ala Ala Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ala Ala Ala Val Ser Ala Val His Arg Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Ser Gly Gly Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly 
                485                 490                 495     


Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Gly Ser Ser Gly Gly 
            500                 505                 510         


Gly Ser Gly Thr Ala Gly Gly His Ser Gly Leu Ser Ser Asn Phe Asn 
        515                 520                 525             


Glu Trp Tyr Val 
    530         


<210>  34
<211>  501
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(501)
<223>  IRX3, UniProtKB Accession Number: P78415-1

<400>  34

Met Ser Phe Pro Gln Leu Gly Tyr Gln Tyr Ile Arg Pro Leu Tyr Pro 
1               5                   10                  15      


Ser Glu Arg Pro Gly Ala Ala Gly Gly Ser Gly Gly Ser Ala Gly Ala 
            20                  25                  30          


Arg Gly Gly Leu Gly Ala Gly Ala Ser Glu Leu Asn Ala Ser Gly Ser 
        35                  40                  45              


Leu Ser Asn Val Leu Ser Ser Val Tyr Gly Ala Pro Tyr Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Gln Gly Tyr Gly Ala Phe Leu Pro Tyr Ala 
65                  70                  75                  80  


Ala Glu Leu Pro Ile Phe Pro Gln Leu Gly Ala Gln Tyr Glu Leu Lys 
                85                  90                  95      


Asp Ser Pro Gly Val Gln His Pro Ala Ala Ala Ala Ala Phe Pro His 
            100                 105                 110         


Pro His Pro Ala Phe Tyr Pro Tyr Gly Gln Tyr Gln Phe Gly Asp Pro 
        115                 120                 125             


Ser Arg Pro Lys Asn Ala Thr Arg Glu Ser Thr Ser Thr Leu Lys Ala 
    130                 135                 140                 


Trp Leu Asn Glu His Arg Lys Asn Pro Tyr Pro Thr Lys Gly Glu Lys 
145                 150                 155                 160 


Ile Met Leu Ala Ile Ile Thr Lys Met Thr Leu Thr Gln Val Ser Thr 
                165                 170                 175     


Trp Phe Ala Asn Ala Arg Arg Arg Leu Lys Lys Glu Asn Lys Met Thr 
            180                 185                 190         


Trp Ala Pro Arg Ser Arg Thr Asp Glu Glu Gly Asn Ala Tyr Gly Ser 
        195                 200                 205             


Glu Arg Glu Glu Glu Asp Glu Glu Glu Asp Glu Glu Asp Gly Lys Arg 
    210                 215                 220                 


Glu Leu Glu Leu Glu Glu Glu Glu Leu Gly Gly Glu Glu Glu Asp Thr 
225                 230                 235                 240 


Gly Gly Glu Gly Leu Ala Asp Asp Asp Glu Asp Glu Glu Ile Asp Leu 
                245                 250                 255     


Glu Asn Leu Asp Gly Ala Ala Thr Glu Pro Glu Leu Ser Leu Ala Gly 
            260                 265                 270         


Ala Ala Arg Arg Asp Gly Asp Leu Gly Leu Gly Pro Ile Ser Asp Ser 
        275                 280                 285             


Lys Asn Ser Asp Ser Glu Asp Ser Ser Glu Gly Leu Glu Asp Arg Pro 
    290                 295                 300                 


Leu Pro Val Leu Ser Leu Ala Pro Ala Pro Pro Pro Val Ala Val Ala 
305                 310                 315                 320 


Ser Pro Ser Leu Pro Ser Pro Pro Val Ser Leu Asp Pro Cys Ala Pro 
                325                 330                 335     


Ala Pro Ala Pro Ala Ser Ala Leu Gln Lys Pro Lys Ile Trp Ser Leu 
            340                 345                 350         


Ala Glu Thr Ala Thr Ser Pro Asp Asn Pro Arg Arg Ser Pro Pro Gly 
        355                 360                 365             


Ala Gly Gly Ser Pro Pro Gly Ala Ala Val Ala Pro Ser Ala Leu Gln 
    370                 375                 380                 


Leu Ser Pro Ala Ala Ala Ala Ala Ala Ala His Arg Leu Val Ser Ala 
385                 390                 395                 400 


Pro Leu Gly Lys Phe Pro Ala Trp Thr Asn Arg Pro Phe Pro Gly Pro 
                405                 410                 415     


Pro Pro Gly Pro Arg Leu His Pro Leu Ser Leu Leu Gly Ser Ala Pro 
            420                 425                 430         


Pro His Leu Leu Gly Leu Pro Gly Ala Ala Gly His Pro Ala Ala Ala 
        435                 440                 445             


Ala Ala Phe Ala Arg Pro Ala Glu Pro Glu Gly Gly Thr Asp Arg Cys 
    450                 455                 460                 


Ser Ala Leu Glu Val Glu Lys Lys Leu Leu Lys Thr Ala Phe Gln Pro 
465                 470                 475                 480 


Val Pro Arg Arg Pro Gln Asn His Leu Asp Ala Ala Leu Val Leu Ser 
                485                 490                 495     


Ala Leu Ser Ser Ser 
            500     


<210>  35
<211>  391
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(391)
<223>  SOX1, UniProtKB Accession Number: O00570-1

<400>  35

Met Tyr Ser Met Met Met Glu Thr Asp Leu His Ser Pro Gly Gly Ala 
1               5                   10                  15      


Gln Ala Pro Thr Asn Leu Ser Gly Pro Ala Gly Ala Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Lys Ala Asn Gln 
        35                  40                  45              


Asp Arg Val Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser Arg Gly 
    50                  55                  60                  


Gln Arg Arg Lys Met Ala Gln Glu Asn Pro Lys Met His Asn Ser Glu 
65                  70                  75                  80  


Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys Val Met Ser Glu Ala Glu 
                85                  90                  95      


Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg Leu Arg Ala Leu His Met 
            100                 105                 110         


Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro Arg Arg Lys Thr Lys Thr 
        115                 120                 125             


Leu Leu Lys Lys Asp Lys Tyr Ser Leu Ala Gly Gly Leu Leu Ala Ala 
    130                 135                 140                 


Gly Ala Gly Gly Gly Gly Ala Ala Val Ala Met Gly Val Gly Val Gly 
145                 150                 155                 160 


Val Gly Ala Ala Ala Val Gly Gln Arg Leu Glu Ser Pro Gly Gly Ala 
                165                 170                 175     


Ala Gly Gly Gly Tyr Ala His Val Asn Gly Trp Ala Asn Gly Ala Tyr 
            180                 185                 190         


Pro Gly Ser Val Ala Ala Ala Ala Ala Ala Ala Ala Met Met Gln Glu 
        195                 200                 205             


Ala Gln Leu Ala Tyr Gly Gln His Pro Gly Ala Gly Gly Ala His Pro 
    210                 215                 220                 


His Ala His Pro Ala His Pro His Pro His His Pro His Ala His Pro 
225                 230                 235                 240 


His Asn Pro Gln Pro Met His Arg Tyr Asp Met Gly Ala Leu Gln Tyr 
                245                 250                 255     


Ser Pro Ile Ser Asn Ser Gln Gly Tyr Met Ser Ala Ser Pro Ser Gly 
            260                 265                 270         


Tyr Gly Gly Leu Pro Tyr Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        275                 280                 285             


Gly Gly Ala His Gln Asn Ser Ala Val Ala Ala Ala Ala Ala Ala Ala 
    290                 295                 300                 


Ala Ala Ser Ser Gly Ala Leu Gly Ala Leu Gly Ser Leu Val Lys Ser 
305                 310                 315                 320 


Glu Pro Ser Gly Ser Pro Pro Ala Pro Ala His Ser Arg Ala Pro Cys 
                325                 330                 335     


Pro Gly Asp Leu Arg Glu Met Ile Ser Met Tyr Leu Pro Ala Gly Glu 
            340                 345                 350         


Gly Gly Asp Pro Ala Ala Ala Ala Ala Ala Ala Ala Gln Ser Arg Leu 
        355                 360                 365             


His Ser Leu Pro Gln His Tyr Gln Gly Ala Gly Ala Gly Val Asn Gly 
    370                 375                 380                 


Thr Val Pro Leu Thr His Ile 
385                 390     


<210>  36
<211>  441
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(441)
<223>  SOX11, UniProtKB Accession Number: P35716-1

<400>  36

Met Val Gln Gln Ala Glu Ser Leu Glu Ala Glu Ser Asn Leu Pro Arg 
1               5                   10                  15      


Glu Ala Leu Asp Thr Glu Glu Gly Glu Phe Met Ala Cys Ser Pro Val 
            20                  25                  30          


Ala Leu Asp Glu Ser Asp Pro Asp Trp Cys Lys Thr Ala Ser Gly His 
        35                  40                  45              


Ile Lys Arg Pro Met Asn Ala Phe Met Val Trp Ser Lys Ile Glu Arg 
    50                  55                  60                  


Arg Lys Ile Met Glu Gln Ser Pro Asp Met His Asn Ala Glu Ile Ser 
65                  70                  75                  80  


Lys Arg Leu Gly Lys Arg Trp Lys Met Leu Lys Asp Ser Glu Lys Ile 
                85                  90                  95      


Pro Phe Ile Arg Glu Ala Glu Arg Leu Arg Leu Lys His Met Ala Asp 
            100                 105                 110         


Tyr Pro Asp Tyr Lys Tyr Arg Pro Arg Lys Lys Pro Lys Met Asp Pro 
        115                 120                 125             


Ser Ala Lys Pro Ser Ala Ser Gln Ser Pro Glu Lys Ser Ala Ala Gly 
    130                 135                 140                 


Gly Gly Gly Gly Ser Ala Gly Gly Gly Ala Gly Gly Ala Lys Thr Ser 
145                 150                 155                 160 


Lys Gly Ser Ser Lys Lys Cys Gly Lys Leu Lys Ala Pro Ala Ala Ala 
                165                 170                 175     


Gly Ala Lys Ala Gly Ala Gly Lys Ala Ala Gln Ser Gly Asp Tyr Gly 
            180                 185                 190         


Gly Ala Gly Asp Asp Tyr Val Leu Gly Ser Leu Arg Val Ser Gly Ser 
        195                 200                 205             


Gly Gly Gly Gly Ala Gly Lys Thr Val Lys Cys Val Phe Leu Asp Glu 
    210                 215                 220                 


Asp Asp Asp Asp Asp Asp Asp Asp Asp Glu Leu Gln Leu Gln Ile Lys 
225                 230                 235                 240 


Gln Glu Pro Asp Glu Glu Asp Glu Glu Pro Pro His Gln Gln Leu Leu 
                245                 250                 255     


Gln Pro Pro Gly Gln Gln Pro Ser Gln Leu Leu Arg Arg Tyr Asn Val 
            260                 265                 270         


Ala Lys Val Pro Ala Ser Pro Thr Leu Ser Ser Ser Ala Glu Ser Pro 
        275                 280                 285             


Glu Gly Ala Ser Leu Tyr Asp Glu Val Arg Ala Gly Ala Thr Ser Gly 
    290                 295                 300                 


Ala Gly Gly Gly Ser Arg Leu Tyr Tyr Ser Phe Lys Asn Ile Thr Lys 
305                 310                 315                 320 


Gln His Pro Pro Pro Leu Ala Gln Pro Ala Leu Ser Pro Ala Ser Ser 
                325                 330                 335     


Arg Ser Val Ser Thr Ser Ser Ser Ser Ser Ser Gly Ser Ser Ser Gly 
            340                 345                 350         


Ser Ser Gly Glu Asp Ala Asp Asp Leu Met Phe Asp Leu Ser Leu Asn 
        355                 360                 365             


Phe Ser Gln Ser Ala His Ser Ala Ser Glu Gln Gln Leu Gly Gly Gly 
    370                 375                 380                 


Ala Ala Ala Gly Asn Leu Ser Leu Ser Leu Val Asp Lys Asp Leu Asp 
385                 390                 395                 400 


Ser Phe Ser Glu Gly Ser Leu Gly Ser His Phe Glu Phe Pro Asp Tyr 
                405                 410                 415     


Cys Thr Pro Glu Leu Ser Glu Met Ile Ala Gly Asp Trp Leu Glu Ala 
            420                 425                 430         


Asn Phe Ser Asp Leu Val Phe Thr Tyr 
        435                 440     


<210>  37
<211>  371
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(371)
<223>  NKX2-1, UniProtKB Accession Number: P43699-1

<400>  37

Met Ser Met Ser Pro Lys His Thr Thr Pro Phe Ser Val Ser Asp Ile 
1               5                   10                  15      


Leu Ser Pro Leu Glu Glu Ser Tyr Lys Lys Val Gly Met Glu Gly Gly 
            20                  25                  30          


Gly Leu Gly Ala Pro Leu Ala Ala Tyr Arg Gln Gly Gln Ala Ala Pro 
        35                  40                  45              


Pro Thr Ala Ala Met Gln Gln His Ala Val Gly His His Gly Ala Val 
    50                  55                  60                  


Thr Ala Ala Tyr His Met Thr Ala Ala Gly Val Pro Gln Leu Ser His 
65                  70                  75                  80  


Ser Ala Val Gly Gly Tyr Cys Asn Gly Asn Leu Gly Asn Met Ser Glu 
                85                  90                  95      


Leu Pro Pro Tyr Gln Asp Thr Met Arg Asn Ser Ala Ser Gly Pro Gly 
            100                 105                 110         


Trp Tyr Gly Ala Asn Pro Asp Pro Arg Phe Pro Ala Ile Ser Arg Phe 
        115                 120                 125             


Met Gly Pro Ala Ser Gly Met Asn Met Ser Gly Met Gly Gly Leu Gly 
    130                 135                 140                 


Ser Leu Gly Asp Val Ser Lys Asn Met Ala Pro Leu Pro Ser Ala Pro 
145                 150                 155                 160 


Arg Arg Lys Arg Arg Val Leu Phe Ser Gln Ala Gln Val Tyr Glu Leu 
                165                 170                 175     


Glu Arg Arg Phe Lys Gln Gln Lys Tyr Leu Ser Ala Pro Glu Arg Glu 
            180                 185                 190         


His Leu Ala Ser Met Ile His Leu Thr Pro Thr Gln Val Lys Ile Trp 
        195                 200                 205             


Phe Gln Asn His Arg Tyr Lys Met Lys Arg Gln Ala Lys Asp Lys Ala 
    210                 215                 220                 


Ala Gln Gln Gln Leu Gln Gln Asp Ser Gly Gly Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Gly Thr Gly Cys Pro Gln Gln Gln Gln Ala Gln Gln Gln Ser Pro Arg 
                245                 250                 255     


Arg Val Ala Val Pro Val Leu Val Lys Asp Gly Lys Pro Cys Gln Ala 
            260                 265                 270         


Gly Ala Pro Ala Pro Gly Ala Ala Ser Leu Gln Gly His Ala Gln Gln 
        275                 280                 285             


Gln Ala Gln His Gln Ala Gln Ala Ala Gln Ala Ala Ala Ala Ala Ile 
    290                 295                 300                 


Ser Val Gly Ser Gly Gly Ala Gly Leu Gly Ala His Pro Gly His Gln 
305                 310                 315                 320 


Pro Gly Ser Ala Gly Gln Ser Pro Asp Leu Ala His His Ala Ala Ser 
                325                 330                 335     


Pro Ala Ala Leu Gln Gly Gln Val Ser Ser Leu Ser His Leu Asn Ser 
            340                 345                 350         


Ser Gly Ser Asp Tyr Gly Thr Met Ser Cys Ser Thr Leu Leu Tyr Gly 
        355                 360                 365             


Arg Thr Trp 
    370     


<210>  38
<211>  868
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(868)
<223>  TRIM71, UniProtKB Accession Number: Q2Q1W2-1

<400>  38

Met Ala Ser Phe Pro Glu Thr Asp Phe Gln Ile Cys Leu Leu Cys Lys 
1               5                   10                  15      


Glu Met Cys Gly Ser Pro Ala Pro Leu Ser Ser Asn Ser Ser Ala Ser 
            20                  25                  30          


Ser Ser Ser Ser Gln Thr Ser Thr Ser Ser Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Gly Ala Ala Ala Arg Arg Leu His Val Leu Pro Cys Leu His Ala 
    50                  55                  60                  


Phe Cys Arg Pro Cys Leu Glu Ala His Arg Leu Pro Ala Ala Gly Gly 
65                  70                  75                  80  


Gly Ala Ala Gly Glu Pro Leu Lys Leu Arg Cys Pro Val Cys Asp Gln 
                85                  90                  95      


Lys Val Val Leu Ala Glu Ala Ala Gly Met Asp Ala Leu Pro Ser Ser 
            100                 105                 110         


Ala Phe Leu Leu Ser Asn Leu Leu Asp Ala Val Val Ala Thr Ala Asp 
        115                 120                 125             


Glu Pro Pro Pro Lys Asn Gly Arg Ala Gly Ala Pro Ala Gly Ala Gly 
    130                 135                 140                 


Gly His Ser Asn His Arg His His Ala His His Ala His Pro Arg Ala 
145                 150                 155                 160 


Ser Ala Ser Ala Pro Pro Leu Pro Gln Ala Pro Gln Pro Pro Ala Pro 
                165                 170                 175     


Ser Arg Ser Ala Pro Gly Gly Pro Ala Ala Ser Pro Ser Ala Leu Leu 
            180                 185                 190         


Leu Arg Arg Pro His Gly Cys Ser Ser Cys Asp Glu Gly Asn Ala Ala 
        195                 200                 205             


Ser Ser Arg Cys Leu Asp Cys Gln Glu His Leu Cys Asp Asn Cys Val 
    210                 215                 220                 


Arg Ala His Gln Arg Val Arg Leu Thr Lys Asp His Tyr Ile Glu Arg 
225                 230                 235                 240 


Gly Pro Pro Gly Pro Gly Ala Ala Ala Ala Ala Gln Gln Leu Gly Leu 
                245                 250                 255     


Gly Pro Pro Phe Pro Gly Pro Pro Phe Ser Ile Leu Ser Val Phe Pro 
            260                 265                 270         


Glu Arg Leu Gly Phe Cys Gln His His Asp Asp Glu Val Leu His Leu 
        275                 280                 285             


Tyr Cys Asp Thr Cys Ser Val Pro Ile Cys Arg Glu Cys Thr Met Gly 
    290                 295                 300                 


Arg His Gly Gly His Ser Phe Ile Tyr Leu Gln Glu Ala Leu Gln Asp 
305                 310                 315                 320 


Ser Arg Ala Leu Thr Ile Gln Leu Leu Ala Asp Ala Gln Gln Gly Arg 
                325                 330                 335     


Gln Ala Ile Gln Leu Ser Ile Glu Gln Ala Gln Thr Val Ala Glu Gln 
            340                 345                 350         


Val Glu Met Lys Ala Lys Val Val Gln Ser Glu Val Lys Ala Val Thr 
        355                 360                 365             


Ala Arg His Lys Lys Ala Leu Glu Glu Arg Glu Cys Glu Leu Leu Trp 
    370                 375                 380                 


Lys Val Glu Lys Ile Arg Gln Val Lys Ala Lys Ser Leu Tyr Leu Gln 
385                 390                 395                 400 


Val Glu Lys Leu Arg Gln Asn Leu Asn Lys Leu Glu Ser Thr Ile Ser 
                405                 410                 415     


Ala Val Gln Gln Val Leu Glu Glu Gly Arg Ala Leu Asp Ile Leu Leu 
            420                 425                 430         


Ala Arg Asp Arg Met Leu Ala Gln Val Gln Glu Leu Lys Thr Val Arg 
        435                 440                 445             


Ser Leu Leu Gln Pro Gln Glu Asp Asp Arg Val Met Phe Thr Pro Pro 
    450                 455                 460                 


Asp Gln Ala Leu Tyr Leu Ala Ile Lys Ser Phe Gly Phe Val Ser Ser 
465                 470                 475                 480 


Gly Ala Phe Ala Pro Leu Thr Lys Ala Thr Gly Asp Gly Leu Lys Arg 
                485                 490                 495     


Ala Leu Gln Gly Lys Val Ala Ser Phe Thr Val Ile Gly Tyr Asp His 
            500                 505                 510         


Asp Gly Glu Pro Arg Leu Ser Gly Gly Asp Leu Met Ser Ala Val Val 
        515                 520                 525             


Leu Gly Pro Asp Gly Asn Leu Phe Gly Ala Glu Val Ser Asp Gln Gln 
    530                 535                 540                 


Asn Gly Thr Tyr Val Val Ser Tyr Arg Pro Gln Leu Glu Gly Glu His 
545                 550                 555                 560 


Leu Val Ser Val Thr Leu Cys Asn Gln His Ile Glu Asn Ser Pro Phe 
                565                 570                 575     


Lys Val Val Val Lys Ser Gly Arg Ser Tyr Val Gly Ile Gly Leu Pro 
            580                 585                 590         


Gly Leu Ser Phe Gly Ser Glu Gly Asp Ser Asp Gly Lys Leu Cys Arg 
        595                 600                 605             


Pro Trp Gly Val Ser Val Asp Lys Glu Gly Tyr Ile Ile Val Ala Asp 
    610                 615                 620                 


Arg Ser Asn Asn Arg Ile Gln Val Phe Lys Pro Cys Gly Ala Phe His 
625                 630                 635                 640 


His Lys Phe Gly Thr Leu Gly Ser Arg Pro Gly Gln Phe Asp Arg Pro 
                645                 650                 655     


Ala Gly Val Ala Cys Asp Ala Ser Arg Arg Ile Val Val Ala Asp Lys 
            660                 665                 670         


Asp Asn His Arg Ile Gln Ile Phe Thr Phe Glu Gly Gln Phe Leu Leu 
        675                 680                 685             


Lys Phe Gly Glu Lys Gly Thr Lys Asn Gly Gln Phe Asn Tyr Pro Trp 
    690                 695                 700                 


Asp Val Ala Val Asn Ser Glu Gly Lys Ile Leu Val Ser Asp Thr Arg 
705                 710                 715                 720 


Asn His Arg Ile Gln Leu Phe Gly Pro Asp Gly Val Phe Leu Asn Lys 
                725                 730                 735     


Tyr Gly Phe Glu Gly Ala Leu Trp Lys His Phe Asp Ser Pro Arg Gly 
            740                 745                 750         


Val Ala Phe Asn His Glu Gly His Leu Val Val Thr Asp Phe Asn Asn 
        755                 760                 765             


His Arg Leu Leu Val Ile His Pro Asp Cys Gln Ser Ala Arg Phe Leu 
    770                 775                 780                 


Gly Ser Glu Gly Thr Gly Asn Gly Gln Phe Leu Arg Pro Gln Gly Val 
785                 790                 795                 800 


Ala Val Asp Gln Glu Gly Arg Ile Ile Val Ala Asp Ser Arg Asn His 
                805                 810                 815     


Arg Val Gln Met Phe Glu Ser Asn Gly Ser Phe Leu Cys Lys Phe Gly 
            820                 825                 830         


Ala Gln Gly Ser Gly Phe Gly Gln Met Asp Arg Pro Ser Gly Ile Ala 
        835                 840                 845             


Ile Thr Pro Asp Gly Met Ile Val Val Val Asp Phe Gly Asn Asn Arg 
    850                 855                 860                 


Ile Leu Val Phe 
865             


<210>  39
<211>  325
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(325)
<223>  FOXB1, UniProtKB Accession Number: Q99853-1

<400>  39

Met Pro Arg Pro Gly Arg Asn Thr Tyr Ser Asp Gln Lys Pro Pro Tyr 
1               5                   10                  15      


Ser Tyr Ile Ser Leu Thr Ala Met Ala Ile Gln Ser Ser Pro Glu Lys 
            20                  25                  30          


Met Leu Pro Leu Ser Glu Ile Tyr Lys Phe Ile Met Asp Arg Phe Pro 
        35                  40                  45              


Tyr Tyr Arg Glu Asn Thr Gln Arg Trp Gln Asn Ser Leu Arg His Asn 
    50                  55                  60                  


Leu Ser Phe Asn Asp Cys Phe Ile Lys Ile Pro Arg Arg Pro Asp Gln 
65                  70                  75                  80  


Pro Gly Lys Gly Ser Phe Trp Ala Leu His Pro Ser Cys Gly Asp Met 
                85                  90                  95      


Phe Glu Asn Gly Ser Phe Leu Arg Arg Arg Lys Arg Phe Lys Val Leu 
            100                 105                 110         


Lys Ser Asp His Leu Ala Pro Ser Lys Pro Ala Asp Ala Ala Gln Tyr 
        115                 120                 125             


Leu Gln Gln Gln Ala Lys Leu Arg Leu Ser Ala Leu Ala Ala Ser Gly 
    130                 135                 140                 


Thr His Leu Pro Gln Met Pro Ala Ala Ala Tyr Asn Leu Gly Gly Val 
145                 150                 155                 160 


Ala Gln Pro Ser Gly Phe Lys His Pro Phe Ala Ile Glu Asn Ile Ile 
                165                 170                 175     


Ala Arg Glu Tyr Lys Met Pro Gly Gly Leu Ala Phe Ser Ala Met Gln 
            180                 185                 190         


Pro Val Pro Ala Ala Tyr Pro Leu Pro Asn Gln Leu Thr Thr Met Gly 
        195                 200                 205             


Ser Ser Leu Gly Thr Gly Trp Pro His Val Tyr Gly Ser Ala Gly Met 
    210                 215                 220                 


Ile Asp Ser Ala Thr Pro Ile Ser Met Ala Ser Gly Asp Tyr Ser Ala 
225                 230                 235                 240 


Tyr Gly Val Pro Leu Lys Pro Leu Cys His Ala Ala Gly Gln Thr Leu 
                245                 250                 255     


Pro Ala Ile Pro Val Pro Ile Lys Pro Thr Pro Ala Ala Val Pro Ala 
            260                 265                 270         


Leu Pro Ala Leu Pro Ala Pro Ile Pro Thr Leu Leu Ser Asn Ser Pro 
        275                 280                 285             


Pro Ser Leu Ser Pro Thr Ser Ser Gln Thr Ala Thr Ser Gln Ser Ser 
    290                 295                 300                 


Pro Ala Thr Pro Ser Glu Thr Leu Thr Ser Pro Ala Ser Ala Leu His 
305                 310                 315                 320 


Ser Val Ala Val His 
                325 


