                         б

<110>  йѧԺ΢о
 
<120>  һ֦¹״ԭ¹״缰ƱӦ

<130>  1087-200261IB

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  455
<212>  PRT
<213>  ˹УArtificial sequence


<220>
<221>  DOMAIN
<222>  (1)..(455)
<223>  MERS-CoV SףGenBank:AFS88936.1RBD367-602д2019
       -nCoV WH01SУGenBank:YP_009724390RBD319-537

<400>  1

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
    210                 215                 220                 


Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Arg Val Gln Pro 
225                 230                 235                 240 


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                245                 250                 255     


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
            260                 265                 270         


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        275                 280                 285             


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
    290                 295                 300                 


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
305                 310                 315                 320 


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
                325                 330                 335     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
            340                 345                 350         


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
        355                 360                 365             


Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
    370                 375                 380                 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly 
385                 390                 395                 400 


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
                405                 410                 415     


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
            420                 425                 430         


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
        435                 440                 445             


Thr Asn Leu Val Lys Asn Lys 
    450                 455 


<210>  2
<211>  437
<212>  PRT
<213>  ˹УArtificial sequence


<220>
<221>  DOMAIN
<222>  (1)..(437)
<223>  2019-nCoV WH01SУGenBank: 
       YP_009724390RBD 319-537SARS -CoV SףGenBank: 
       NP_828851RBD 306-523

<400>  2

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Arg Val Val Pro Ser 
    210                 215                 220                 


Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
225                 230                 235                 240 


Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg 
                245                 250                 255     


Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
            260                 265                 270         


Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu 
        275                 280                 285             


Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys 
    290                 295                 300                 


Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala 
305                 310                 315                 320 


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala 
                325                 330                 335     


Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr 
            340                 345                 350         


Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp 
        355                 360                 365             


Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro 
    370                 375                 380                 


Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr 
385                 390                 395                 400 


Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
                405                 410                 415     


Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr Asp 
            420                 425                 430         


Leu Ile Lys Asn Gln 
        435         


<210>  3
<211>  454
<212>  PRT
<213>  ˹УArtificial sequence


<220>
<221>  DOMAIN
<222>  (1)..(454)
<223>  MERS-CoV SףGenBank:AFS88936.1RBD 367-602д2019
       -nCoV SףGenBank: NP_828851RBD 306-523

<400>  3

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
    210                 215                 220                 


Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Arg Val Val Pro 
225                 230                 235                 240 


Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
                245                 250                 255     


Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu 
            260                 265                 270         


Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
        275                 280                 285             


Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys 
    290                 295                 300                 


Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val 
305                 310                 315                 320 


Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile 
                325                 330                 335     


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu 
            340                 345                 350         


Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn 
        355                 360                 365             


Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg 
    370                 375                 380                 


Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro 
385                 390                 395                 400 


Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr 
                405                 410                 415     


Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            420                 425                 430         


Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr 
        435                 440                 445             


Asp Leu Ile Lys Asn Gln 
    450                 


<210>  4
<211>  1434
<212>  DNA
<213>  ˹УArtificial sequence


<220>
<221>  gene
<222>  (1)..(1434)
<223>  SEQ ID NO.1 MERS-nCoV鵰׵DNAУб鰱źĵDNAУ

<400>  4
atgatacact cagtgtttct actgatgttc ttgttaacac ctacagaaag tgaagcaaaa       60

ccttctggct cagttgtgga acaggctgaa ggtgttgaat gtgatttttc acctcttctg      120

tctggcacac ctcctcaggt ttataatttc aagcgtttgg tttttaccaa ttgcaattat      180

aatcttacca aattgctttc acttttttct gtgaatgatt ttacttgtag tcaaatatct      240

ccagcagcaa ttgctagcaa ctgttattct tcactgattt tggattactt ttcataccca      300

cttagtatga aatccgatct cagtgttagt tctgctggtc caatatccca gtttaattat      360

aaacagtcct tttctaatcc cacatgtttg attttagcga ctgttcctca taaccttact      420

actattacta agcctcttaa gtacagctat attaacaagt gctctcgtct tctttctgat      480

gatcgtactg aagtacctca gttagtgaac gctaatcaat actcaccctg tgtatccatt      540

gtcccatcca ctgtgtggga agacggtgat tattatagga aacaactatc tccacttgaa      600

ggtggtggct ggcttgttgc tagtggctca actgttgcca tgactgagca attacagatg      660

ggctttggta ttacagttca atatggtaca gacaccaata gtgtttgccc caagcttgaa      720

tttgctaatg acacaaaaat tgcctctcaa ttaggcaatc gtgttcagcc tactgaatcg      780

atcgtgaggt tcccaaatat taccaatctg tgtccgttcg gagaggtctt caatgcgact      840

cgattcgcgt ctgtttacgc ctggaacagg aaacggatta gcaattgtgt cgctgactat      900

tcggtcttat acaactctgc atcattctca accttcaagt gttatggtgt cagccctaca      960

aagctgaatg acttatgttt caccaatgtt tatgcggaca gtttcgtaat acgaggtgat     1020

gaagtccgcc aaattgcacc cggacaaacc ggcaagatag ccgactataa ttataagctc     1080

cctgatgact ttacgggctg tgtcatagct tggaatagta ataatttgga ctcgaaagtg     1140

ggaggtaatt ataattatct ctatagactg ttccggaaat caaatctcaa gccctttgaa     1200

cgggacataa gtacagaaat ctaccaagct ggttccacgc cgtgtaatgg agtcgagggg     1260

tttaactgtt atttcccgct ccagtcgtat gggttccagc caacgaatgg cgtcggatac     1320

caaccttacc gcgttgtagt attaagcttt gaactgttgc acgcgcccgc gactgtttgt     1380

ggcccgaaga agtcgactaa tctagtaaag aataagcatc atcaccacca ccac           1434


<210>  5
<211>  1380
<212>  DNA
<213>  ˹УArtificial sequence


<220>
<221>  gene
<222>  (1)..(1380)
<223>  SEQ ID NO.2 nCoV-SARS鵰׵DNAУб鰱źĵDNAУ

<400>  5
atgatccact cagtgtttct cttaatgttt ctactaactc ccacggagtc gcgagtgcag       60

cctaccgaaa gcatcgtccg tttcccgaat attactaatc tctgtccatt cggagaagtc      120

ttcaatgcca cccgattcgc ttccgtttac gcgtggaacc gtaaacgaat atctaattgt      180

gttgcggact attccgtgtt gtacaactca gcatcattct ctacttttaa atgctatgga      240

gtgtcgccga ctaaactcaa cgacttgtgt ttcactaatg tttatgctga ctctttcgtt      300

attcgtggag acgaagttcg tcaaatcgca ccagggcaaa ctggcaagat tgcggactat      360

aattataagc tgccagatga ctttaccgga tgtgtaatag cctggaactc aaataatctc      420

gacagtaaag tgggaggcaa ctataattat ctttatcgac tcttcagaaa gtctaacctt      480

aagccatttg aacgtgacat ttctacagaa atttaccaag ccggctctac accttgcaat      540

ggcgtggaag ggtttaactg ttatttccca ttacagtctt atggtttcca gccaactaat      600

ggtgtgggat accaacctta ccgcgtcgtt gtcctgtcgt ttgaattgct tcacgcacca      660

gccaccgttt gtgggccaaa gaagagcact aatctcgtaa agaataaacg tgttgtccca      720

tccggtgacg ttgtccggtt tcctaacatc acaaacttgt gtccctttgg cgaagtcttc      780

aatgctacca aatttcccag cgtctacgcg tgggaaagaa agaaaatatc aaattgtgtt      840

gccgactatt ccgtcctata taatagcacg ttcttctcga cgttcaagtg ttatggtgtc      900

tctgctacga aacttaacga cttatgtttc tcaaacgtgt acgcagattc tttcgtagtt      960

aaaggtgatg atgtgaggca gattgcgccc ggacaaacag gagtaatcgc cgattacaac     1020

tacaaactcc cggacgactt tatggggtgt gtgttagctt ggaatacgag gaatatagac     1080

gccacgagta ccgggaatta taattataag tatcgctatc tccgacatgg caaactcagg     1140

ccatttgaac gcgacattag caatgttcca ttctctccgg acggcaaacc gtgcactcca     1200

ccggctttaa attgttattg gccgttaaac gactatggct tttatacaac gacgggaata     1260

gggtaccaac cttacagagt agtagtacta agtttcgagc tattaaatgc gccggccacc     1320

gtatgtgggc ccaagctatc gacggaccta atcaagaatc agcaccacca ccaccaccac     1380


<210>  6
<211>  1431
<212>  DNA
<213>  ˹УArtificial sequence


<220>
<221>  gene
<222>  (1)..(1431)
<223>  SEQ ID NO.3 MERS-SARS鵰׵DNAУб鰱źĵDNAУ

<400>  6
atgatacact cagtgtttct actgatgttc ttgttaacac ctacagaaag tgaagcaaaa       60

ccttctggct cagttgtgga acaggctgaa ggtgttgaat gtgatttttc acctcttctg      120

tctggcacac ctcctcaggt ttataatttc aagcgtttgg tttttaccaa ttgcaattat      180

aatcttacca aattgctttc acttttttct gtgaatgatt ttacttgtag tcaaatatct      240

ccagcagcaa ttgctagcaa ctgttattct tcactgattt tggattactt ttcataccca      300

cttagtatga aatccgatct cagtgttagt tctgctggtc caatatccca gtttaattat      360

aaacagtcct tttctaatcc cacatgtttg attttagcga ctgttcctca taaccttact      420

actattacta agcctcttaa gtacagctat attaacaagt gctctcgtct tctttctgat      480

gatcgtactg aagtacctca gttagtgaac gctaatcaat actcaccctg tgtatccatt      540

gtcccatcca ctgtgtggga agacggtgat tattatagga aacaactatc tccacttgaa      600

ggtggtggct ggcttgttgc tagtggctca actgttgcca tgactgagca attacagatg      660

ggctttggta ttacagttca atatggtaca gacaccaata gtgtttgccc caagcttgaa      720

tttgctaatg acacaaaaat tgcctctcaa ttaggcaatc gtgttgtccc atccggtgac      780

gttgtccggt ttcctaacat cacaaacttg tgtccctttg gcgaagtctt caatgctacc      840

aaatttccca gcgtctacgc gtgggaaaga aagaaaatat caaattgtgt tgccgactat      900

tccgtcctat ataatagcac gttcttctcg acgttcaagt gttatggtgt ctctgctacg      960

aaacttaacg acttatgttt ctcaaacgtg tacgcagatt ctttcgtagt taaaggtgat     1020

gatgtgaggc agattgcgcc cggacaaaca ggagtaatcg ccgattacaa ctacaaactc     1080

ccggacgact ttatggggtg tgtgttagct tggaatacga ggaatataga cgccacgagt     1140

accgggaatt ataattataa gtatcgctat ctccgacatg gcaaactcag gccatttgaa     1200

cgcgacatta gcaatgttcc attctctccg gacggcaaac cgtgcactcc accggcttta     1260

aattgttatt ggccgttaaa cgactatggc ttttatacaa cgacgggaat agggtaccaa     1320

ccttacagag tagtagtact aagtttcgag ctattaaatg cgccggccac cgtatgtggg     1380

cccaagctat cgacggacct aatcaagaat cagcaccacc accaccacca c              1431


<210>  7
<211>  240
<212>  PRT
<213>  MERS-CoV


<220>
<221>  DOMAIN
<222>  (1)..(240)
<223>  MERS-CoV SףGenBank:AFS88936.1RBD 367-606

<400>  7

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
    210                 215                 220                 


Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr 
225                 230                 235                 240 


<210>  8
<211>  223
<212>  PRT
<213>  nCoV


<220>
<221>  DOMAIN
<222>  (1)..(223)
<223>  2019-nCoV WH01SУGenBank: 
       YP_009724390RBD 319-541

<400>  8

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  9
<211>  222
<212>  PRT
<213>  SARS-CoV


<220>
<221>  DOMAIN
<222>  (1)..(222)
<223>  SARS -CoV SףGenBank: NP_828851RBD 306-527

<400>  9

Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     


Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         


Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             


Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe 
    210                 215                 220         


<210>  10
<211>  720
<212>  DNA
<213>  MERS-CoV


<220>
<221>  gene
<222>  (1)..(720)
<223>  SEQ ID NO.7 MERS-CoV S RBD 367-606еDNA

<400>  10
gaagcaaaac cttctggctc agttgtggaa caggctgaag gtgttgaatg tgatttttca       60

cctcttctgt ctggcacacc tcctcaggtt tataatttca agcgtttggt ttttaccaat      120

tgcaattata atcttaccaa attgctttca cttttttctg tgaatgattt tacttgtagt      180

caaatatctc cagcagcaat tgctagcaac tgttattctt cactgatttt ggattacttt      240

tcatacccac ttagtatgaa atccgatctc agtgttagtt ctgctggtcc aatatcccag      300

tttaattata aacagtcctt ttctaatccc acatgtttga ttttagcgac tgttcctcat      360

aaccttacta ctattactaa gcctcttaag tacagctata ttaacaagtg ctctcgtctt      420

ctttctgatg atcgtactga agtacctcag ttagtgaacg ctaatcaata ctcaccctgt      480

gtatccattg tcccatccac tgtgtgggaa gacggtgatt attataggaa acaactatct      540

ccacttgaag gtggtggctg gcttgttgct agtggctcaa ctgttgccat gactgagcaa      600

ttacagatgg gctttggtat tacagttcaa tatggtacag acaccaatag tgtttgcccc      660

aagcttgaat ttgctaatga cacaaaaatt gcctctcaat taggcaattg cgtggaatac      720


<210>  11
<211>  669
<212>  DNA
<213>  nCoV


<220>
<221>  gene
<222>  (1)..(669)
<223>  SEQ ID NO.8 2019-nCoV WH01SRBD 319-541еDNA

<400>  11
agagtgcaac ctacagaatc aatcgtgaga tttcctaaca tcacaaacct ttgccctttc       60

ggcgaggtgt ttaacgcaac aagatttgca tcagtgtacg catggaacag aaagcgtata      120

tcaaactgcg tggcagatta ctcagtgctt tacaactcag catcattcag tacgtttaaa      180

tgctacggag tgtcacctac aaagctaaat gatctttgct ttacaaacgt gtacgcagat      240

tcatttgtga tcagaggaga tgaagtgaga caaatcgcac ctggacaaac aggaaagatt      300

gccgattaca actacaaact tcctgatgat ttcaccggct gcgtgatcgc atggaactca      360

aacaaccttg attcaaaggt aggtggtaat tataattatt tgtataggct ctttcgtaag      420

agcaacttaa agccatttga gcgagatatc tcaacagaaa tctaccaagc aggatcaaca      480

ccttgcaacg gagtggaagg atttaactgc tactttcctc ttcaatcata cggatttcaa      540

cctacaaacg gagtgggata ccaaccttac agagtggtgg tgctttcatt tgaacttctt      600

cacgcacctg caacagtgtg cggacctaag aagagcacga accttgtgaa gaataagtgc      660

gtgaacttt                                                              669


<210>  12
<211>  666
<212>  DNA
<213>  SARS-CoV


<220>
<221>  gene
<222>  (1)..(666)
<223>  SEQ ID NO.9 SARS -CoV S RBD 306-527еDNA

<400>  12
cgtgttgtcc catccggtga cgttgtccgg tttcctaaca tcacaaactt gtgtcccttt       60

ggcgaagtct tcaatgctac caaatttccc agcgtctacg cgtgggaaag aaagaaaata      120

tcaaattgtg ttgccgacta ttccgtccta tataatagca cgttcttctc gacgttcaag      180

tgttatggtg tctctgctac gaaacttaac gacttatgtt tctcaaacgt gtacgcagat      240

tctttcgtag ttaaaggtga tgatgtgagg cagattgcgc ccggacaaac aggagtaatc      300

gccgattaca actacaaact cccggacgac tttatggggt gtgtgttagc ttggaatacg      360

aggaatatag acgccacgag taccgggaat tataattata agtatcgcta tctccgacat      420

ggcaaactca ggccatttga acgcgacatt agcaatgttc cattctctcc ggacggcaaa      480

ccgtgcactc caccggcttt aaattgttat tggccgttaa acgactatgg cttttataca      540

acgacgggaa tagggtacca accttacaga gtagtagtac taagtttcga gctattaaat      600

gcgccggcca ccgtatgtgg gcccaagcta tcgacggacc taatcaagaa tcagtgtgtt      660

aatttc                                                                 666


<210>  13
<211>  236
<212>  PRT
<213>  MERS-CoV


<220>
<221>  DOMAIN
<222>  (1)..(236)
<223>  MERS-CoV SףGenBank:AFS88936.1RBD 367-602

<400>  13

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
    210                 215                 220                 


Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn 
225                 230                 235     


<210>  14
<211>  219
<212>  PRT
<213>  nCoV


<220>
<221>  DOMAIN
<222>  (1)..(219)
<223>  2019-nCoV WH01SУGenBank: 
       YP_009724390RBD 319-537

<400>  14

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys 
    210                 215                 


<210>  15
<211>  218
<212>  PRT
<213>  SARS-CoV


<220>
<221>  DOMAIN
<222>  (1)..(218)
<223>  SARS -CoV SףGenBank: NP_828851RBD 306-523

<400>  15

Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          


Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         


Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 


Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     


Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         


Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             


Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln 
    210                 215             


<210>  16
<211>  20
<212>  DNA
<213>  ˹УArtificial sequence

<220>
<221>  misc_feature
<223>  ڼ¹ڲNN-F

<400>  16
gaccccaaaa tcagcgaaat                                                   20


<210>  17
<211>  24
<212>  DNA
<213>  ˹УArtificial sequence

<220>
<221>  misc_feature
<223>  ڼ¹ڲNķN-R

<400>  17
tctggttact gccagttgaa tctg                                              24


<210>  18
<211>  24
<212>  DNA
<213>  ˹УArtificial sequence

<220>
<221>  misc_feature
<223>  ڼ¹ڲN̽N-probe

<400>  18
accccgcatt acgtttggtg gacc                                              24


<210>  19
<211>  23
<212>  DNA
<213>  ˹УArtificial sequence

<220>
<221>  misc_feature
<223>  ڼ¹ڲsgRNAsgRNA-F

<400>  19
cgatctcttg tagatctgtt ctc                                               23


<210>  20
<211>  22
<212>  DNA
<213>  ˹УArtificial sequence

<220>
<221>  misc_feature
<223>  ڼ¹ڲsgRNAķsgRNA-R

<400>  20
tgtgtgcgta ctgctgcaat at                                                22


<210>  21
<211>  26
<212>  DNA
<213>  ˹УArtificial sequence

<220>
<221>  misc_feature
<223>  ڼ¹ڲsgRNA̽sgRNA-probe

<400>  21
acactagcca tccttactgc gcttcg                                            26


