                         SEQUENCE LISTING

<110>  TSINGHUA UNIVERSITY
 
<120>  Novel Use of Oridonin or Oridonin Derivative

<130>  PIDC3203348P

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  912
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the wild type human allel of DNMT3A

<400>  1

Met Pro Ala Met Pro Ser Ser Gly Pro Gly Asp Thr Ser Ser Ser Ala 
1               5                   10                  15      


Ala Glu Arg Glu Glu Asp Arg Lys Asp Gly Glu Glu Gln Glu Glu Pro 
            20                  25                  30          


Arg Gly Lys Glu Glu Arg Gln Glu Pro Ser Thr Thr Ala Arg Lys Val 
        35                  40                  45              


Gly Arg Pro Gly Arg Lys Arg Lys His Pro Pro Val Glu Ser Gly Asp 
    50                  55                  60                  


Thr Pro Lys Asp Pro Ala Val Ile Ser Lys Ser Pro Ser Met Ala Gln 
65                  70                  75                  80  


Asp Ser Gly Ala Ser Glu Leu Leu Pro Asn Gly Asp Leu Glu Lys Arg 
                85                  90                  95      


Ser Glu Pro Gln Pro Glu Glu Gly Ser Pro Ala Gly Gly Gln Lys Gly 
            100                 105                 110         


Gly Ala Pro Ala Glu Gly Glu Gly Ala Ala Glu Thr Leu Pro Glu Ala 
        115                 120                 125             


Ser Arg Ala Val Glu Asn Gly Cys Cys Thr Pro Lys Glu Gly Arg Gly 
    130                 135                 140                 


Ala Pro Ala Glu Ala Gly Lys Glu Gln Lys Glu Thr Asn Ile Glu Ser 
145                 150                 155                 160 


Met Lys Met Glu Gly Ser Arg Gly Arg Leu Arg Gly Gly Leu Gly Trp 
                165                 170                 175     


Glu Ser Ser Leu Arg Gln Arg Pro Met Pro Arg Leu Thr Phe Gln Ala 
            180                 185                 190         


Gly Asp Pro Tyr Tyr Ile Ser Lys Arg Lys Arg Asp Glu Trp Leu Ala 
        195                 200                 205             


Arg Trp Lys Arg Glu Ala Glu Lys Lys Ala Lys Val Ile Ala Gly Met 
    210                 215                 220                 


Asn Ala Val Glu Glu Asn Gln Gly Pro Gly Glu Ser Gln Lys Val Glu 
225                 230                 235                 240 


Glu Ala Ser Pro Pro Ala Val Gln Gln Pro Thr Asp Pro Ala Ser Pro 
                245                 250                 255     


Thr Val Ala Thr Thr Pro Glu Pro Val Gly Ser Asp Ala Gly Asp Lys 
            260                 265                 270         


Asn Ala Thr Lys Ala Gly Asp Asp Glu Pro Glu Tyr Glu Asp Gly Arg 
        275                 280                 285             


Gly Phe Gly Ile Gly Glu Leu Val Trp Gly Lys Leu Arg Gly Phe Ser 
    290                 295                 300                 


Trp Trp Pro Gly Arg Ile Val Ser Trp Trp Met Thr Gly Arg Ser Arg 
305                 310                 315                 320 


Ala Ala Glu Gly Thr Arg Trp Val Met Trp Phe Gly Asp Gly Lys Phe 
                325                 330                 335     


Ser Val Val Cys Val Glu Lys Leu Met Pro Leu Ser Ser Phe Cys Ser 
            340                 345                 350         


Ala Phe His Gln Ala Thr Tyr Asn Lys Gln Pro Met Tyr Arg Lys Ala 
        355                 360                 365             


Ile Tyr Glu Val Leu Gln Val Ala Ser Ser Arg Ala Gly Lys Leu Phe 
    370                 375                 380                 


Pro Val Cys His Asp Ser Asp Glu Ser Asp Thr Ala Lys Ala Val Glu 
385                 390                 395                 400 


Val Gln Asn Lys Pro Met Ile Glu Trp Ala Leu Gly Gly Phe Gln Pro 
                405                 410                 415     


Ser Gly Pro Lys Gly Leu Glu Pro Pro Glu Glu Glu Lys Asn Pro Tyr 
            420                 425                 430         


Lys Glu Val Tyr Thr Asp Met Trp Val Glu Pro Glu Ala Ala Ala Tyr 
        435                 440                 445             


Ala Pro Pro Pro Pro Ala Lys Lys Pro Arg Lys Ser Thr Ala Glu Lys 
    450                 455                 460                 


Pro Lys Val Lys Glu Ile Ile Asp Glu Arg Thr Arg Glu Arg Leu Val 
465                 470                 475                 480 


Tyr Glu Val Arg Gln Lys Cys Arg Asn Ile Glu Asp Ile Cys Ile Ser 
                485                 490                 495     


Cys Gly Ser Leu Asn Val Thr Leu Glu His Pro Leu Phe Val Gly Gly 
            500                 505                 510         


Met Cys Gln Asn Cys Lys Asn Cys Phe Leu Glu Cys Ala Tyr Gln Tyr 
        515                 520                 525             


Asp Asp Asp Gly Tyr Gln Ser Tyr Cys Thr Ile Cys Cys Gly Gly Arg 
    530                 535                 540                 


Glu Val Leu Met Cys Gly Asn Asn Asn Cys Cys Arg Cys Phe Cys Val 
545                 550                 555                 560 


Glu Cys Val Asp Leu Leu Val Gly Pro Gly Ala Ala Gln Ala Ala Ile 
                565                 570                 575     


Lys Glu Asp Pro Trp Asn Cys Tyr Met Cys Gly His Lys Gly Thr Tyr 
            580                 585                 590         


Gly Leu Leu Arg Arg Arg Glu Asp Trp Pro Ser Arg Leu Gln Met Phe 
        595                 600                 605             


Phe Ala Asn Asn His Asp Gln Glu Phe Asp Pro Pro Lys Val Tyr Pro 
    610                 615                 620                 


Pro Val Pro Ala Glu Lys Arg Lys Pro Ile Arg Val Leu Ser Leu Phe 
625                 630                 635                 640 


Asp Gly Ile Ala Thr Gly Leu Leu Val Leu Lys Asp Leu Gly Ile Gln 
                645                 650                 655     


Val Asp Arg Tyr Ile Ala Ser Glu Val Cys Glu Asp Ser Ile Thr Val 
            660                 665                 670         


Gly Met Val Arg His Gln Gly Lys Ile Met Tyr Val Gly Asp Val Arg 
        675                 680                 685             


Ser Val Thr Gln Lys His Ile Gln Glu Trp Gly Pro Phe Asp Leu Val 
    690                 695                 700                 


Ile Gly Gly Ser Pro Cys Asn Asp Leu Ser Ile Val Asn Pro Ala Arg 
705                 710                 715                 720 


Lys Gly Leu Tyr Glu Gly Thr Gly Arg Leu Phe Phe Glu Phe Tyr Arg 
                725                 730                 735     


Leu Leu His Asp Ala Arg Pro Lys Glu Gly Asp Asp Arg Pro Phe Phe 
            740                 745                 750         


Trp Leu Phe Glu Asn Val Val Ala Met Gly Val Ser Asp Lys Arg Asp 
        755                 760                 765             


Ile Ser Arg Phe Leu Glu Ser Asn Pro Val Met Ile Asp Ala Lys Glu 
    770                 775                 780                 


Val Ser Ala Ala His Arg Ala Arg Tyr Phe Trp Gly Asn Leu Pro Gly 
785                 790                 795                 800 


Met Asn Arg Pro Leu Ala Ser Thr Val Asn Asp Lys Leu Glu Leu Gln 
                805                 810                 815     


Glu Cys Leu Glu His Gly Arg Ile Ala Lys Phe Ser Lys Val Arg Thr 
            820                 825                 830         


Ile Thr Thr Arg Ser Asn Ser Ile Lys Gln Gly Lys Asp Gln His Phe 
        835                 840                 845             


Pro Val Phe Met Asn Glu Lys Glu Asp Ile Leu Trp Cys Thr Glu Met 
    850                 855                 860                 


Glu Arg Val Phe Gly Phe Pro Val His Tyr Thr Asp Val Ser Asn Met 
865                 870                 875                 880 


Ser Arg Leu Ala Arg Gln Arg Leu Leu Gly Arg Ser Trp Ser Val Pro 
                885                 890                 895     


Val Ile Arg His Leu Phe Ala Pro Leu Lys Glu Tyr Phe Ala Cys Val 
            900                 905                 910         


